WorldWideScience

Sample records for association avhs relation

  1. AVH- kuntoutujan lepo- ja ruokailuasennot

    OpenAIRE

    Polenov, Heidi

    2015-01-01

    Aivoverenkiertohäiriö (AVH) on koko maailmassa toiseksi yleisin kuolinsyy ja usein siitä jää potilaalle jokin pysyvä haitta, halvaus, afasia tai muu kognitiivinen häiriö. Oirekuva voi vaihdella lievistä ongelmista vakaviin toiminnanhäiriöihin. Tyypillinen oire AVH-potilaalla on toispuolihalvaus vaurioon nähden vastakkaisella puolella kehoa ja noin 50 prosenttia potilaista kärsii nielemisvaikeuksista. Asentohoidon keinoin voidaan edistää AVH- kuntoutujan paranemista ja kuntoutumista se...

  2. Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences

    Science.gov (United States)

    Laj, Carlo; Cifelli, Francesca

    2015-04-01

    The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. These GIFT workshops represented the first workshops specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

  3. Acute viral hepatitis morbidity and mortality associated with hepatitis E virus infection: Uzbekistan surveillance data

    OpenAIRE

    Margolis Harold S; Onischenko Gennady G; Yashina Tatiana L; Brown Matthew S; Favorov Michael O; Sharapov Makhmudkhan B; Chorba Terence L

    2009-01-01

    Abstract Background In Uzbekistan, routine serologic testing has not been available to differentiate etiologies of acute viral hepatitis (AVH). To determine the age groups most affected by hepatitis E virus (HEV) during documented AVH epidemics, trends in AVH-associated mortality rate (MR) per 100,000 over a 15-year period and reported incidence of AVH over a 35-year period were examined. Methods Reported AVH incidence data from 1971 to 2005 and AVH-associated mortality data from 1981 to 1995...

  4. An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.

    LENUS (Irish Health Repository)

    Tracy, D K

    2010-01-01

    Auditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal cortices and are refractory to pharmacological and psychological treatment in approximately 25% of patients. Low frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex has been demonstrated to be effective in reducing AVH in some patients, although results have varied. The cortical mechanism by which rTMS exerts its effects remain unknown, although data from the motor system is suggestive of a local cortical inhibitory effect. We explored neuroimaging differences in healthy volunteers between application of a clinically utilized rTMS protocol and a sham rTMS equivalent when undertaking a prosodic auditory task.

  5. Acute viral hepatitis morbidity and mortality associated with hepatitis E virus infection: Uzbekistan surveillance data

    Directory of Open Access Journals (Sweden)

    Margolis Harold S

    2009-03-01

    Full Text Available Abstract Background In Uzbekistan, routine serologic testing has not been available to differentiate etiologies of acute viral hepatitis (AVH. To determine the age groups most affected by hepatitis E virus (HEV during documented AVH epidemics, trends in AVH-associated mortality rate (MR per 100,000 over a 15-year period and reported incidence of AVH over a 35-year period were examined. Methods Reported AVH incidence data from 1971 to 2005 and AVH-associated mortality data from 1981 to 1995 were examined. Serologic markers for infection with hepatitis viruses A, B, D, and E were determined from a sample of hospitalized patients with AVH from an epidemic period (1987 and from a sample of pregnant women with AVH from a non-epidemic period (1992. Results Two multi-year AVH outbreaks were identified: one during 1975–1976, and one during 1985–1987. During 1985–1987, AVH-associated MRs were 12.3–17.8 per 100,000 for the general population. Highest AVH-associated MRs occurred among children in the first 3 years of life (40–190 per 100,000 and among women aged 20–29 (15–21 per 100,000. During 1988–1995 when reported AVH morbidity was much lower in the general population, AVH-associated MRs were markedly lower among these same age groups. In 1988, AVH-associated MRs were higher in rural (21 per 100,000 than in urban (8 per 100,000 populations (RR 2.6; 95% CI 1.16–5.93; p Conclusion In the absence of the availability of confirmatory testing, inferences regarding probable hepatitis epidemic etiologies can sometimes be made using surveillance data, comparing AVH incidence with AVH-associated mortality with an eye to population-based viral hepatitis control measures. Data presented here implicate HEV as the probable etiology of high mortality observed in pregnant women and in children less than 3 years of age in Uzbekistan during 1985–1987. High mortality among pregnant women but not among children less than 3 years has been observed in

  6. Tilings and associated relational structures

    CERN Document Server

    Oger, Francis

    2009-01-01

    In the present paper, as we did previously in [5], we investigate the relations between the geometric properties of tilings and the algebraic and model-theoretic properties of associated relational structures. Our study is motivated by the existence of aperiodic tilings. In [5], we considered tilings of the euclidean spaces of finite dimension, and isomorphism was defined up to translation. Here, we consider, more generally, tilings of a metric space, and isomorphism is defined modulo an arbitrary group of isometries. The results of Sections 1 and 2 concern, in particular, the characterization of relational structures which can be represented by tilings of some given type, local isomorphism and the extraction preorder. In Section 3, we show that the notions of periodicity and invariance through a translation, defined for tilings of the euclidean spaces of finite dimension, can be generalized, with appropriate hypotheses, to relational structures, and in particular to tilings of non-euclidean spaces. In Sectio...

  7. On the associative Nijenhuis Relation

    OpenAIRE

    Ebrahimi-Fard, Kurusch

    2003-01-01

    In this brief note we would like to give the construction of a free commutative unital associative Nijenhuis algebra on a commutative unital associative algebra based on an augmented modified quasi-shuffle product.

  8. Association Rules in the Relational Calculus

    CERN Document Server

    Schulte, Oliver; Ester, Martin; Lu, Zhiyong

    2007-01-01

    One of the most utilized data mining tasks is the search for association rules. Association rules represent significant relationships between items in transactions. We extend the concept of association rule to represent a much broader class of associations, which we refer to as \\emph{entity-relationship rules.} Semantically, entity-relationship rules express associations between properties of related objects. Syntactically, these rules are based on a broad subclass of safe domain relational calculus queries. We propose a new definition of support and confidence for entity-relationship rules and for the frequency of entity-relationship queries. We prove that the definition of frequency satisfies standard probability axioms and the Apriori property.

  9. Categorical and associative relations increase false memory relative to purely associative relations.

    Science.gov (United States)

    Coane, Jennifer H; McBride, Dawn M; Termonen, Miia-Liisa; Cutting, J Cooper

    2016-01-01

    The goal of the present study was to examine the contributions of associative strength and similarity in terms of shared features to the production of false memories in the Deese/Roediger-McDermott list-learning paradigm. Whereas the activation/monitoring account suggests that false memories are driven by automatic associative activation from list items to nonpresented lures, combined with errors in source monitoring, other accounts (e.g., fuzzy trace theory, global-matching models) emphasize the importance of semantic-level similarity, and thus predict that shared features between list and lure items will increase false memory. Participants studied lists of nine items related to a nonpresented lure. Half of the lists consisted of items that were associated but did not share features with the lure, and the other half included items that were equally associated but also shared features with the lure (in many cases, these were taxonomically related items). The two types of lists were carefully matched in terms of a variety of lexical and semantic factors, and the same lures were used across list types. In two experiments, false recognition of the critical lures was greater following the study of lists that shared features with the critical lure, suggesting that similarity at a categorical or taxonomic level contributes to false memory above and beyond associative strength. We refer to this phenomenon as a "feature boost" that reflects additive effects of shared meaning and association strength and is generally consistent with accounts of false memory that have emphasized thematic or feature-level similarity among studied and nonstudied representations. PMID:26250805

  10. Religiosity in young adolescents with auditory vocal hallucinations.

    Science.gov (United States)

    Steenhuis, Laura A; Bartels-Velthuis, Agna A; Jenner, Jack A; Aleman, André; Bruggeman, Richard; Nauta, Maaike H; Pijnenborg, Gerdina H M

    2016-02-28

    The current exploratory study examined the associations between auditory vocal hallucinations (AVH) and delusions and religiosity in young adolescents. 337 children from a population-based case-control study with and without AVH, were assessed after five years at age 12 and 13, on the presence and appraisal of AVH, delusions and religiosity. AVH status (persistent, remittent, incident or control) was examined in relationship to religiosity. Results demonstrated a non-linear association between AVH and religiosity. Moderately religious adolescents were more likely to report AVH than non-religious adolescents (O.R.=2.6). Prospectively, moderately religious adolescents were more likely to have recently developed AVH than non-religious adolescents (O.R.=3.6) and strongly religious adolescents (O.R.=7.9). Of the adolescents reporting voices in this sample (16.3%), more than half reported positive voices. Religious beliefs were often described as supportive, useful or neutral (82%), regardless of the level of religiosity, for both adolescents with and without AVH. Co-occurrence of AVH and delusions, and severity of AVH were not related to religiosity. The present findings suggest there may be a non-linear association between religiosity and hearing voices in young adolescents. A speculative explanation may be that religious practices were adopted in response to AVH as a method of coping. PMID:26774188

  11. Auditing Associative Relations across Two Knowledge Sources

    Science.gov (United States)

    Vizenor, Lowell T.; Bodenreider, Olivier; McCray, Alexa T.

    2009-01-01

    Objectives This paper proposes a novel semantic method for auditing associative relations in biomedical terminologies. We tested our methodology on two Unified Medical Language System (UMLS) knowledge sources. Methods We use the UMLS semantic groups as high-level representations of the domain and range of relationships in the Metathesaurus and in the Semantic Network. A mapping created between Metathesaurus relationships and Semantic Network relationships forms the basis for comparing the signatures of a given Metathesaurus relationship to the signatures of the semantic relationship to which it is mapped. The consistency of Metathesaurus relations is studied for each relationship. Results Of the 177 associative relationships in the Metathesaurus, 84 (48%) exhibit a high degree of consistency with the corresponding Semantic Network relationships. Overall, 63% of the 1.8M associative relations in the Metathesaurus are consistent with relations in the Semantic Network. Conclusion The semantics of associative relationships in biomedical terminologies should be defined explicitly by their developers. The Semantic Network would benefit from being extended with new relationships and with new relations for some existing relationships. The UMLS editing environment could take advantage of the correspondence established between relationships in the Metathesaurus and the Semantic Network. Finally, the auditing method also yielded useful information for refining the mapping of associative relationships between the two sources. PMID:19475724

  12. Neuroimaging of voice hearing in non-psychotic individuals: A mini review of recent fMRI, PET, DTI and EEG studies

    Directory of Open Access Journals (Sweden)

    Kelly Maria Johanna Diederen

    2012-05-01

    Full Text Available Auditory verbal hallucinations (AVH or ‘voices’ are a characteristic symptom of schizophrenia, but can also be observed in healthy individuals in the general population. As these non-psychotic individuals experience AVH in the absence of other psychiatric symptoms and medication-use they provide an excellent model to study AVH in isolation. Indeed a number of studies used this approach and investigated brain structure and function in non-psychotic individuals with AVH.These studies showed that aberrant connectivity of language production and perception areas is particularly associated with AVH. This is in concordance with investigations that observed prominent activation of these language areas during the state of AVH. Effortful attention decreased cerebral dominance for language and dopamine dysfunction on the other hand, are presumably not specifically related to AVH.

  13. Associative Mechanisms and Drug-Related Behavior

    OpenAIRE

    Weiss, Stanley J.; Reilly, Mark P.; Kearns, David N.

    2005-01-01

    This special issue of the International Journal of Comparative Psychology is based on presentations delivered at the Focus Session of the 2004 Winter Conference on Animal Learning and Behavior (WCALB) held in Winter Park, Colorado. The Associative Mechanisms and Drug-Related Behavior Focus Session began with an invited address by Shepard Siegel titled The Ghost in the Addict: Drug Anticipation and Drug Addiction. He described an impressive body of research showing that conditioning mechanisms...

  14. Association maps and related emotional loadings

    Czech Academy of Sciences Publication Activity Database

    Lukavský, Jiří

    Budapest: Hungarian Cognitive Science Foundation, 2007. s. 85. [Toward a Science of Consciousness 2007. 23.07.2007-26.07.2007, Budapest] Institutional research plan: CEZ:AV0Z70250504 Keywords : semantic proximity * Word Association Test * Semantic Selection Test Subject RIV: AN - Psychology http://www.tsc2007.org/TSC2007abstracts.pdf

  15. On the priority vector associated with a fuzzy preference relation and a multiplicative preference relation.

    OpenAIRE

    Fedrizzi, Michele; Brunelli, Matteo

    2008-01-01

    We propose two straightforward methods for deriving the priority vector associated with a fuzzy preference relation. Then, using transformations between multiplicative preference relations and fuzzy preference relations, we study the relationships between the priority vectors associated with these two types of preference relations.

  16. Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India

    Institute of Scientific and Technical Information of China (English)

    M Irshad; Y Sharma; I Dhar; J Singh; YK Joshi

    2006-01-01

    AIM: To describe the prevalence of transfusiontransmitted virus (TTV) infection in association with hepatitis A-E viral infections in different forms of liver diseases in North India.METHODS: Sera from a total number of:137 patients,including 37 patients with acute viral hepatitis (AVH), 37patients with chronic viral hepatitis (CVH), 31 patients with cirrhosis of liver and 32 patients with fulminant hepatic failure (FHF), were analyzed both for TTV-DNA and hepatitis A-E viral markers. Presence of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis E virus (HEV) infections was detected in different proportions in different groups. Moreover, TTV-DNA was simultaneously tested in 100 healthy blood donors also.RESULTS: None of the patients had hepatitis A virus (HAV) and hepatitis D virus (HDV) infections. Overall prevalence of TTV-DNA was detected in 27.1% cases with AVH, 18.9% cases with CVH, 48.4% cases with cirrhosis and 9.4% cases with FHF. TTV-DNA simultaneously tested in 100 healthy blood donors showed 27% positivity. On establishing a relation between TTV infection with other hepatitis viral infections, TTV demonstrated co-infection with HBV, HCV and HEV in these disease groups. Correlation of TTV with ALT level in sera did not demonstrate high ALT level in TTV-infected patients, suggesting that TTV does not cause severe liver damage.CONCLUSION: TTV infection is prevalent both in patients and healthy individuals in India. However, it does not have any significant correlation with other hepatitis viral infections, nor does it produce an evidence of severe liver damage in patients with liver diseases.

  17. Auditory verbal hallucinations in schizophrenia and post-traumatic stress disorder: common phenomenology, common cause, common interventions?

    Science.gov (United States)

    McCarthy-Jones, Simon; Longden, Eleanor

    2015-01-01

    Auditory verbal hallucinations (AVH: ‘hearing voices’) are found in both schizophrenia and post-traumatic stress disorder (PTSD). In this paper we first demonstrate that AVH in these two diagnoses share a qualitatively similar phenomenology. We then show that the presence of AVH in schizophrenia is often associated with earlier exposure to traumatic/emotionally overwhelming events, as it is by definition in PTSD. We next argue that the content of AVH relates to earlier traumatic events in a similar way in both PTSD and schizophrenia, most commonly having direct or indirect thematic links to emotionally overwhelming events, rather than being direct re-experiencing. We then propose, following cognitive models of PTSD, that the reconstructive nature of memory may be able to account for the nature of these associations between trauma and AVH content, as may threat-hypervigilance and the individual’s personal goals. We conclude that a notable subset of people diagnosed with schizophrenia with AVH are having phenomenologically and aetiologically identical experiences to PTSD patients who hear voices. As such we propose that the iron curtain between AVH in PTSD (often termed ‘dissociative AVH’) and AVH in schizophrenia (so-called ‘psychotic AVH’) needs to be torn down, as these are often the same experience. One implication of this is that these trauma-related AVH require a common trans-diagnostic treatment strategy. Whilst antipsychotics are already increasingly being used to treat AVH in PTSD, we argue for the centrality of trauma-based interventions for trauma-based AVH in both PTSD and in people diagnosed with schizophrenia. PMID:26283997

  18. Cumulative semantic interference for associative relations in language production.

    Science.gov (United States)

    Rose, Sebastian Benjamin; Abdel Rahman, Rasha

    2016-07-01

    Associations between conceptual representations and thematic relations play an important role in the organization of semantic memory. However, language production research on semantic context effects shows that associative (e.g., dog and bone) and categorical relations (dog and horse) seem to diverge. While categorical contexts typically induce semantic interference that has traditionally been taken to reflect competitive lexical selection, evidence for comparable associative modulations is rare. In three experiments we tested whether thematic associations between objects induce cumulative interference in the continuous naming paradigm, assuming that this paradigm hampers lexical selection via the activation of highly active lexical cohorts steadily increasing in size. Indeed, naming times increased linearly with each newly named member of thematic contexts irrespective of the pre-activation of associations before the naming task (Experiment 1), and irrespective of whether categorical links were partially included (Experiments 1 and 2) or entirely absent (Experiment 3). These findings demonstrate that different types of semantic relations induce interference. PMID:27015349

  19. Promoter Sequences Prediction Using Relational Association Rule Mining

    OpenAIRE

    Gabriela Czibula; Maria-Iuliana Bocicor; Istvan Gergely Czibula

    2012-01-01

    In this paper we are approaching, from a computational perspective, the problem of promoter sequences prediction, an important problem within the field of bioinformatics. As the conditions for a DNA sequence to function as a promoter are not known, machine learning based classification models are still developed to approach the problem of promoter identification in the DNA. We are proposing a classification model based on relational association rules mining. Relational association rules are a...

  20. Are stress related factors associated with alcohol intake?

    NARCIS (Netherlands)

    van Loon, AJM; Tijhuis, M; Schuit, AJ; van Oers, HAM; Surtees, PG; Ormel, J

    2004-01-01

    Moderate alcohol consumption is related to reduced risks of coronary heart disease and all-cause mortality. Our goal is to advance our understanding of the associations between stress-related factors and alcohol consumption, using cutoff points for alcohol intake that reflect health benefits rather

  1. Increased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations

    DEFF Research Database (Denmark)

    van Lutterveld, Remko; Oranje, Bob; Abramovic, Lucija; Willems, Anne E; Boks, Marco P M; Glenthøj, Birte Y; Kahn, René S; Sommer, Iris E C

    2010-01-01

    ). However, AVH are part of extensive and variable symptomatology in schizophrenia. For this reason non-psychotic individuals with AVH as an isolated symptom provide an excellent opportunity to investigate this relationship. METHODS: P300 waveforms, processing negativity and mismatch negativity were examined......OBJECTIVE: Schizophrenia is associated with aberrant event-related potentials (ERPs) such as reductions in P300, processing negativity and mismatch negativity amplitudes. These deficits may be related to the propensity of schizophrenia patients to experience auditory verbal hallucinations (AVH...... with an auditory oddball paradigm in 18 non-psychotic individuals with AVH and 18 controls. RESULTS: P300 amplitude was increased in the AVH group as compared to controls, reflecting superior effortful attention. A trend in the same direction was found for processing negativity. No significant...

  2. Physical Abuse is Associated with HIV-related Drug Risk

    OpenAIRE

    Reddy, Madhavi K.; Anderson, Bradley J; Liebschutz, Jane; Stein, Michael D.

    2014-01-01

    Those who have experienced abuse may be prone to engaging in risky sexual behavior and risky drug use. The relationship between sexual abuse and risky behavior has been well established in the literature, but the association between physical abuse and risky drug use has been equivocal. We hypothesize that the experience of PTSD symptoms following physical abuse leads to risky drug use. Therefore, we examined the associations among physical abuse history, PTSD symptoms, and HIV-related drug ri...

  3. Ladder operators and recursion relations for the associated Bessel polynomials

    International Nuclear Information System (INIS)

    Introducing the associated Bessel polynomials in terms of two non-negative integers, and under an integrability condition we simultaneously factorize their corresponding differential equation into a product of the ladder operators by four different ways as shape invariance symmetry equations. This procedure gives four different pairs of recursion relations on the associated Bessel polynomials. In spite of description of Bessel and Laguerre polynomials in terms of each other, we show that the associated Bessel differential equation is factorized in four different ways whereas for Laguerre one we have three different ways

  4. Ladder operators and recursion relations for the associated Bessel polynomials

    Science.gov (United States)

    Fakhri, H.; Chenaghlou, A.

    2006-10-01

    Introducing the associated Bessel polynomials in terms of two non-negative integers, and under an integrability condition we simultaneously factorize their corresponding differential equation into a product of the ladder operators by four different ways as shape invariance symmetry equations. This procedure gives four different pairs of recursion relations on the associated Bessel polynomials. In spite of description of Bessel and Laguerre polynomials in terms of each other, we show that the associated Bessel differential equation is factorized in four different ways whereas for Laguerre one we have three different ways.

  5. Ladder operators and recursion relations for the associated Bessel polynomials

    Energy Technology Data Exchange (ETDEWEB)

    Fakhri, H. [Institute for Studies in Theoretical Physics and Mathematics (IPM), PO Box 19395-5531, Tehran (Iran, Islamic Republic of) and Department of Theoretical Physics and Astrophysics, Physics Faculty, Tabriz University, PO Box 51666-16471, Tabriz (Iran, Islamic Republic of)]. E-mail: hfakhri@ipm.ir; Chenaghlou, A. [Institute for Studies in Theoretical Physics and Mathematics (IPM), PO Box 19395-5531, Tehran (Iran, Islamic Republic of) and Physics Department, Faculty of Science, Sahand University of Technology, PO Box 51335-1996, Tabriz (Iran, Islamic Republic of)]. E-mail: a.chenaghlou@sut.ac.ir

    2006-10-30

    Introducing the associated Bessel polynomials in terms of two non-negative integers, and under an integrability condition we simultaneously factorize their corresponding differential equation into a product of the ladder operators by four different ways as shape invariance symmetry equations. This procedure gives four different pairs of recursion relations on the associated Bessel polynomials. In spite of description of Bessel and Laguerre polynomials in terms of each other, we show that the associated Bessel differential equation is factorized in four different ways whereas for Laguerre one we have three different ways.

  6. Factors associated with drug-related harms related to policing in Tijuana, Mexico

    OpenAIRE

    Patterson Thomas L; Anderson Christy M; Lozada Remedios; Volkmann Tyson; Vera Alicia; Strathdee Steffanie A

    2011-01-01

    Abstract Objective To assess factors associated with drug-related harms related to policing among injection drug users (IDUs) in Tijuana, Mexico. Methods IDUs who were over 18 years old and had injected drugs within the last six months were recruited via respondent-driven sampling and underwent questionnaires and testing for HIV (human immunodeficiency virus), syphilis and TB (tuberculosis). Random effects logistic regression was used to simultaneously model factors associated with five drug-...

  7. Factors associated with drug-related harms related to policing in Tijuana, Mexico

    OpenAIRE

    Volkmann, Tyson; Lozada, Remedios; Anderson, Christy M.; Patterson, Thomas L.; Vera, Alicia; Steffanie A Strathdee

    2011-01-01

    Abstract Objective To assess factors associated with drug-related harms related to policing among injection drug users (IDUs) in Tijuana, Mexico. Methods IDUs who were over 18 years old and had injected drugs within the last six months were recruited via respondent-driven sampling and underwent questionnaires and testing for HIV (human immunodeficiency virus), syphilis and TB (tuberculosis). Random effects logistic regression was used to simultaneously model factors associ...

  8. Chromosomal and related Mendelian syndromes associated with Hirschsprung's disease.

    Science.gov (United States)

    Moore, S W

    2012-11-01

    Hirschsprung's disease (HSCR) is a fairly frequent cause of intestinal obstruction in children. It is characterized as a sex-linked heterogonous disorder with variable severity and incomplete penetrance giving rise to a variable pattern of inheritance. Although Hirschsprung's disease occurs as an isolated phenotype in at least 70% of cases, it is not infrequently associated with a number of congenital abnormalities and associated syndromes, demonstrating a spectrum of congenital anomalies. Certain of these syndromic phenotypes have been linked to distinct genetic sites, indicating underlying genetic associations of the disease and probable gene-gene interaction, in its pathogenesis. These associations with HSCR include Down's syndrome and other chromosomal anomalies, Waardenburg syndrome and other Dominant sensorineural deafness, the Congenital Central Hypoventilation and Mowat-Wilson and other brain-related syndromes, as well as the MEN2 and other tumour associations. A number of other autosomal recessive syndromes include the Shah-Waardenburg, the Bardet-Biedl and Cartilage-hair hypoplasia, Goldberg-Shprintzen syndromes and other syndromes related to cholesterol and fat metabolism among others. The genetics of Hirschsprung's disease are highly complex with the majority of known genetic sites relating to the main susceptibility pathways (RET an EDNRB). Non-syndromic non-familial, short-segment HSCR appears to represent a non-Mendelian condition with variable expression and sex-dependent penetrance. Syndromic and familial forms, on the other hand, have complex patterns of inheritance and being reported as autosomal dominant, recessive and polygenic patterns of inheritance. The phenotypic variability and incomplete penetrance observed in Hirschsprung's disease could also be explained by the involvement of modifier genes, especially in its syndromic forms. In this review, we look at the chromosomal and Mendelian associations and their underlying signalling pathways

  9. Relational and Physical Aggression, Prosocial Behavior, and Peer Relations: Gender Moderation and Bidirectional Associations

    Science.gov (United States)

    Zimmer-Gembeck, Melanie J.; Geiger, Tasha C.; Crick, Nicki R.

    2005-01-01

    In this 3-year prospective study (N = 458) spanning a transition to middle school, bidirectional associations between children's relations with schoolmates (social preference and impact) and behaviors (physical and relational aggression, prosocial behavior) were examined using structural equation modeling. Gender moderation of all estimated paths…

  10. Can dryad explain age-related associative memory deficits?

    Science.gov (United States)

    Smyth, Andrea C; Naveh-Benjamin, Moshe

    2016-02-01

    A recent interesting theoretical account of aging and memory judgments, the DRYAD (density of representations yields age-related deficits; Benjamin, 2010; Benjamin, Diaz, Matzen, & Johnson, 2012), attributes the extensive findings of disproportional age-related deficits in memory for source, context, and associations, to a global decline in memory fidelity. It is suggested that this global deficit, possibly due to a decline in attentional processes, is moderated by weak representation of contextual information to result in disproportional age-related declines. In the current article, we evaluate the DRYAD model, comparing it to specific age-related deficits theories, in particular, the ADH (associative deficit hypothesis, Naveh-Benjamin, 2000). We question some of the main assumptions/hypotheses of DRYAD in light of data reported in the literature, and we directly assess the role of attention in age-related deficits by manipulations of divided attention and of the instructions regarding what to pay attention to in 2 experiments (one from the literature and a new one). The results of these experiments fit the predictions of the ADH and do not support the main assumption/hypotheses of DRYAD. (PsycINFO Database Record PMID:25961878

  11. Relative nutritional deficiencies associated with centrally acting monoamines

    OpenAIRE

    Hinz M; Stein A; Uncini T

    2012-01-01

    Marty Hinz1, Alvin Stein2, Thomas Uncini31Clinical Research, NeuroResearch Clinics Inc, Cape Coral, 2Stein Orthopedic Associates, Plantation, FL, 3DBS Labs, Duluth, MN, USABackground: Two primary categories of nutritional deficiency exist. An absolute nutritional deficiency occurs when nutrient intake is not sufficient to meet the normal needs of the system, and a relative nutritional deficiency exists when nutrient intake and systemic levels of nutrients are normal, while a change occurs in ...

  12. Residual Probability Function, Associated Orderings, and Related Aging Classes

    OpenAIRE

    2014-01-01

    The concept of residual probability plays an important role in reliability and life testing. In this investigation, we study further the residual probability order and its related aging classes. Several characterizations and preservation properties of this order under some statistical and reliability operations of monotone transformation, mixture, weighted distributions, and order statistics are discussed. In addition, by comparing the original distribution with its associated equilibrium dis...

  13. Using public relations to promote health: a framing analysis of public relations strategies among health associations.

    Science.gov (United States)

    Park, Hyojung; Reber, Bryan H

    2010-01-01

    This study explored health organizations' public relations efforts to frame health issues through their press releases. Content analysis of 316 press releases from three health organizations-the American Heart Association, the American Cancer Society, and the American Diabetes Association-revealed that they used the medical research frame most frequently and emphasized societal responsibility for health issues. There were differences, however, among the organizations regarding the main frames and health issues: the American Diabetes Association was more likely to focus on the issues related to social support and education, while the American Heart Association and the American Cancer Society were more likely to address medical research and scientific news. To demonstrate their initiatives for public health, all the organizations employed the social support/educational frame most frequently. Researchers and medical doctors frequently were quoted as trusted sources in the releases. PMID:20390976

  14. Creativity related cortex activity in the remote associates task.

    Science.gov (United States)

    Razumnikova, Olga M

    2007-06-15

    The involvement of different oscillating neuronal systems during verbal creative thinking was investigated by multi-channel EEG measuring. The remote associates task (RAT) as a model of creative thinking in comparison to the resting condition and the simple associates task (SAT) was used. The EEG coherence along with spectral power density estimates were evaluated in each of the six frequency bands in 4-30 Hz range. We have found out RAT-related EEG changes mainly in the theta1, alpha1, alpha2 and beta2 bands. The RAT-induced cortical activation was differed from the SAT-induced EEG pattern by (i) widespread enhancement of power and coherence in the beta2, (ii) the theta1 power increase in the frontal cortex, and (iii) increased desynchronization of the alpha1,alpha2 mainly over posterior cortex together with the alpha1 coherence decrease in the prefrontal sites. Originality scores of the verbal associates positively correlated with an increase of coherence focused in the fronto-parietal regions of both hemispheres in the beta2 and in the left parieto-temporal loci in the alpha1. Additionally, more original responses positively correlated with amplitude of the alpha1 mostly in the left hemisphere. We propose that widespread cortical integration of multi-component internal processing has been simultaneously mediated during creative verbal thinking. The selectively distributed theta, alpha, and beta oscillations reflect intra- and inter-hemispheric communication networks with different functional relations to the RAT solving. The theta1 and alpha1 rhythms seem to specifically relate to top-down information processing such as deliberate sustained attention and working-memory-retention during defocused attention, respectively, whereas larger interregional synchrony in the beta2 band may mediate 'differential' attention to diffusely activating alternative meanings of words and remote associates from coarse semantic coding. PMID:17499642

  15. Relative nutritional deficiencies associated with centrally acting monoamines

    Directory of Open Access Journals (Sweden)

    Hinz M

    2012-05-01

    Full Text Available Marty Hinz1, Alvin Stein2, Thomas Uncini31Clinical Research, NeuroResearch Clinics Inc, Cape Coral, 2Stein Orthopedic Associates, Plantation, FL, 3DBS Labs, Duluth, MN, USABackground: Two primary categories of nutritional deficiency exist. An absolute nutritional deficiency occurs when nutrient intake is not sufficient to meet the normal needs of the system, and a relative nutritional deficiency exists when nutrient intake and systemic levels of nutrients are normal, while a change occurs in the system that induces a nutrient intake requirement that cannot be supplied from diet alone. The purpose of this paper is to demonstrate that the primary component of chronic centrally acting monoamine (serotonin, dopamine, norepinephrine, and epinephrine disease is a relative nutritional deficiency induced by postsynaptic neuron damage.Materials and methods: Monoamine transporter optimization results were investigated, re-evaluated, and correlated with previous publications by the authors under the relative nutritional deficiency hypothesis. Most of those previous publications did not discuss the concept of a relative nutritional deficiency. It is the purpose of this paper to redefine the etiology expressed in these previous writings into the realm of relative nutritional deficiency, as demonstrated by monoamine transporter optimization. The novel and broad range of amino acid precursor dosing values required to address centrally acting monoamine relative nutritional deficiency properly is also discussed.Results: Four primary etiologies are described for postsynaptic neuron damage leading to a centrally acting monoamine relative nutritional deficiency, all of which require monoamine transporter optimization to define the proper amino acid dosing values of serotonin and dopamine precursors.Conclusion: Humans suffering from chronic centrally acting monoamine-related disease are not suffering from a drug deficiency; they are suffering from a relative

  16. Relational and Overt Aggression in Urban India: Associations with Peer Relations and Best Friends' Aggression

    Science.gov (United States)

    Bowker, Julie C.; Ostrov, Jamie M.; Raja, Radhi

    2012-01-01

    This study explored the associations between relational and overt aggression and social status, and tested whether the peer correlates of aggression vary as a function of best friends' aggression during early adolescence in urban India. One hundred and ninety-four young adolescents from primarily middle-to-upper-class families in Surat, India…

  17. Basic research on cancer related to radiation associated medical researches

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong In; Hwang, Dae Yong; Bang, Ho Yoon [and others

    2000-12-01

    Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed.

  18. Basic research on cancer related to radiation associated medical researches

    International Nuclear Information System (INIS)

    Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed

  19. Factors associated with drug-related harms related to policing in Tijuana, Mexico

    Directory of Open Access Journals (Sweden)

    Patterson Thomas L

    2011-04-01

    Full Text Available Abstract Objective To assess factors associated with drug-related harms related to policing among injection drug users (IDUs in Tijuana, Mexico. Methods IDUs who were over 18 years old and had injected drugs within the last six months were recruited via respondent-driven sampling and underwent questionnaires and testing for HIV (human immunodeficiency virus, syphilis and TB (tuberculosis. Random effects logistic regression was used to simultaneously model factors associated with five drug-related harms related to policing practices in the prior six months (i.e., police led them to rush injections; affected where they bought drugs; affected locations where they used drugs; feared that police will interfere with their drug use; receptive syringe sharing. Results Of 727 IDUs, 85% were male; median age was 38 years. Within the last 6 months, 231 (32% of IDUs reported that police had led them to rush injections, affected where they bought or used drugs or were very afraid police would interfere with their drug use, or shared syringes. Factors independently associated with drug-related harms related to policing within the last six months included: recent arrest, homelessness, higher frequencies of drug injection, use of methamphetamine, using the local needle exchange program and perceiving a decrease in the purity of at least one drug. Conclusions IDUs who experienced drug-related harms related to policing were those who were most affected by other micro and macro influences in the physical risk environment. Police education programs are needed to ensure that policing practices do not exacerbate risky behaviors or discourage protective behaviors such as needle exchange program use, which undermines the right to health for people who inject drugs.

  20. Prevention of Device-Related Healthcare-Associated Infections.

    Science.gov (United States)

    Septimus, Edward J; Moody, Julia

    2016-01-01

    Healthcare-associated infections (HAIs) are a leading cause of morbidity and mortality in hospitalized patients. Up to 15% of patients develop an infection while hospitalized in the United States, which accounts for approximately 1.7 million HAIs, 99,000 deaths annually and over 10 billion dollars in costs per year. A significant percentage of HAIs are preventable using evidenced-based strategies. In terms of device-related HAIs it is estimated that 65-70% of catheter-line associated bloodstream infections (CLABSIs) and catheter-associated urinary tract infections (CAUTIs) are preventable. To prevent CLABSIs a bundle which includes hand hygiene prior to insertion and catheter manipulation, use of chlorhexidene alcohol for site preparation and maintenance, use of maximum barrier for catheter insertion, site selection, removing nonessential lines, disinfect catheter hubs before assessing line, and dressing changes are essential elements of basic practices. To prevent CAUTIs a bundle that includes hand hygiene for insertion and catheter or bag manipulation, inserting catheters for appropriate indications, insert using aseptic technique, remove catheters when no longer needed, maintain a close system keeping bag and tubing below the bladder are the key components of basic practices. PMID:26918162

  1. Ambiguities and symmetry relations associated with fermionic tensor densities

    International Nuclear Information System (INIS)

    We consider the consistent evaluation of perturbative (divergent) Green functions associated with fermionic tensor densities and the derivation of symmetry relations for them. We show that, in spite of current algebra methods being not applicable, it is possible to derive symmetry properties analogous to the Ward identities of vector and axial-vector densities. The proposed method, which is applicable to any previously chosen order of perturbative calculation, gives the same results as those of current algebra when such a tool is applicable. By using a very general calculational strategy, concerning the manipulations and calculations involving divergent Feynman integrals, we evaluate the purely fermionic two-point functions containing tensor vertices and derive their symmetry properties. The present investigation is the first step in the study and characterization of possible anomalies involving fermionic tensor densities, particularly in purely fermionic three-point functions

  2. Risk Factors Associated with Peritoneal-Dialysis-Related Peritonitis

    Directory of Open Access Journals (Sweden)

    Julia Kerschbaum

    2012-01-01

    Full Text Available Background. Peritonitis represents a major complication of peritoneal dialysis (PD. The aim of this paper was to systematically collect data on patient-related risk factors for PD-associated peritonitis, to analyze the methodological quality of these studies, and to summarize published evidence on the particular risk factors. Methods. Studies were identified by searches of Pubmed (1990–2012 and assessed for methodological quality by using a modified form of the STROBE criteria. Results. Thirty-five methodologically acceptable studies were identified. The following nonmodifiable risk factors were considered valid and were associated with an increased risk of peritonitis: ethnicity, female gender, chronic lung disease, coronary artery disease, congestive heart failure, cardiovascular disease, hypertension, antihepatitis C virus antibody positivity, diabetes mellitus, lupus nephritis or glomerulonephritis as underlying renal disease, and no residual renal function. We also identified the following modifiable, valid risk factors for peritonitis: malnutrition, overweight, smoking, immunosuppression, no use of oral active vitamin D, psychosocial factors, low socioeconomic status, PD against patient’s choice, and haemodialysis as former modality. Discussion. Modifiable and nonmodifiable risk factors analyzed in this paper might serve as a basis to improve patient care in peritoneal dialysis.

  3. Risk factors for age-related maculopathy are associated with a relative lack of macular pigment.

    Science.gov (United States)

    Nolan, John M; Stack, Jim; O' Donovan, Orla; Loane, Edward; Beatty, Stephen

    2007-01-01

    Macular pigment (MP) is composed of the two dietary carotenoids lutein (L) and zeaxanthin (Z), and is believed to protect against age-related maculopathy (ARM). This study was undertaken to investigate MP optical density with respect to risk factors for ARM, in 828 healthy subjects from an Irish population. MP optical density was measured psychophysically using heterochromatic flicker photometry, serum L and Z were quantified by HPLC, and dietary intake of L and Z was assessed using a validated food-frequency questionnaire. Clinical and personal details were also recorded, with particular attention directed towards risk factors for ARM. We report a statistically significant age-related decline in MP optical density (r2=0.082, p<0.01). Current and past smokers had lower average MP optical density than never smokers and this difference was statistically significant (p<0.01). Subjects with a confirmed family history of ARM had significantly lower levels of MP optical density than subjects with no known family history of disease (p<0.01). For each of these established risk factors, their statistically significant negative association with MP persisted after controlling for the other two, and also after controlling for other potentially confounding variables such as sex, cholesterol, dietary and serum L (p<0.01). In the absence of retinal pathology, and in advance of disease onset, the relative lack of MP seen in association with increasing age, tobacco use and family history of ARM supports the hypothesis that the enhanced risk that these variables represent for ARM may be attributable, at least in part, to a parallel deficiency of macular carotenoids. PMID:17083932

  4. Beliefs about hearing voices.

    Science.gov (United States)

    Connors, Michael H; Robidoux, Serje; Langdon, Robyn; Coltheart, Max

    2016-07-01

    People who experience auditory verbal hallucinations (AVHs) vary in whether they believe their AVHs are self-generated or caused by external agents. It remains unclear whether these differences are influenced by the "intensity" of the voices, such as their frequency or volume, or other aspects of their phenomenology. We examined 35 patients with schizophrenia or schizoaffective disorder who experienced AVHs. Patients completed a detailed structured interview about their AVHs, including beliefs about their cause. In response, 20 (57.1%) reported that their AVHs were self-generated, 9 (25.7%) were uncertain, and 6 (17.1%) reported that their AVHs were caused by external agents. Several analytical approaches revealed little or no evidence for associations between either AVH intensity or phenomenology and beliefs about the AVH's cause; the evidence instead favoured the absence of these associations. Beliefs about the cause of AVHs are thus unlikely to be explained solely by the phenomenological qualities of the AVHs. PMID:27258929

  5. Associations between health behaviours and health related fitness.

    OpenAIRE

    Shephard, R. J.; Bouchard, C

    1996-01-01

    OBJECTIVE: To examine relations between health behaviours and health related fitness. METHODS: Subjects were a convenience sample of 350 healthy adults (172 men, 178 women). Covariance analysis adjusted data for significant influences of age and socioeconomic status. Obesity was assessed by anthropometry and body density. Cardiovascular fitness was assessed and various metabolic measurements were made. Questionnaires on physical activity and health related behaviours were completed. RESULTS: ...

  6. Aggression in toddlers: associations with parenting and marital relations.

    Science.gov (United States)

    Brook, J S; Zheng, L; Whiteman, M; Brook, D W

    2001-06-01

    This study examined the relation among parenting factors, marital relations, and toddler aggression. A structured questionnaire was administered to both parents of 254 2-year-olds. The authors used correlation and hierarchical multiple regression analyses to assess the extent to which certain personality traits, drug use, parenting style, and marital conflicts were related to the toddlers' aggressive behavior. Results showed that the maternal child-rearing and parental aggression domains had a direct effect on toddler aggression. The domain of maternal child rearing also served as a mediator for the domains of marital relations, paternal child rearing, parental aggression, and parental drug use. The findings indicated that maternal child-rearing practices, personality attributes, and drug use were more important than paternal attributes in relation to toddler aggression. Implications for prevention among families at risk are discussed. PMID:11432607

  7. Associations between generic substitution and patient-related factors

    DEFF Research Database (Denmark)

    Østergaard Rathe, Jette

    generically substitutable drug. Data were linked with a prescription database. Results We found no associations between generic substitution and, respectively, gender, age, drug group and polypharmacy. Earlier switches of the index drug are statistically significant associated with acceptance of generic...... more likely to switch again despite skepticism towards generic substitution. Points for discussion at EGPRN Discussion of the results,-that no difference in gender, age, drug group or polypharmacy exists, irrespective of switching generics or not. Discussion of the reason why one earlier index ATC...

  8. Process-related factors associated with disciplinary board decisions

    DEFF Research Database (Denmark)

    Birkeland, Søren; Christensen, René dePont; Damsbo, Niels;

    2013-01-01

    plays with regard to board decision outcomes. Using complaint cases towards general practitioners, the aim of this study was to identify what process factors are statistically associated with disciplinary actions as seen from the party of the complainant and the defendant general practitioner...

  9. Associations between Parental Control and Children's Overt and Relational Aggression

    Science.gov (United States)

    Kuppens, Sofie; Grietens, Hans; Onghena, Patrick; Michiels, Daisy

    2009-01-01

    The present study examined specialized associations between parental control and child aggression in a sample of 600 8- to 10-years old children. Parental control dimensions and aggression subtypes were assessed using multiple informants (i.e. children, mothers, fathers, peers, and teachers). In line with expectations, parental physical punishment…

  10. Associations between parental control and children's overt and relational aggression

    NARCIS (Netherlands)

    Kuppens, Sofie; Grietens, Hans; Onghena, Patrick; Michiels, Daisy

    2009-01-01

    The present study examined specialized associations between parental control and child aggression in a sample of 600 8- to 10-years old children. Parental control dimensions and aggression subtypes were assessed using multiple informants (i.e. children, mothers, fathers, peers, and teachers). In lin

  11. Associative subalgebras of the Griess algebra and related topics

    CERN Document Server

    Dong, C; Mason, G; Norton, S P

    1996-01-01

    It is shown how certain idempotents in the Griess algebra generate the discrete series representations for the Virasoro algebra inside the Frenkel-Lepowsky-Meurman's moonshine module vertex operator algebra. It is also shown that each Niemeier lattice determines (in many ways) certain maximal associative subalgebras of the Griess algebra.

  12. Nonadherence is Associated with Lack of HIV-Related Knowledge

    DEFF Research Database (Denmark)

    Dyrehave, Charlotte; Rasmussen, Dlama Nggida; Hønge, Bo Langhoff;

    2016-01-01

    BACKGROUND: Poor treatment adherence is a main barrier for effective antiretroviral therapy (ART) globally. HIV-related knowledge may affect understanding and utilization of HIV medical information, hence limited health literacy is a known barrier to treatment adherence. DESIGN AND METHODS: A cross...

  13. Environmental distribution of coral-associated relatives of apicomplexan parasites

    Czech Academy of Sciences Publication Activity Database

    Janouškovec, J.; Horák, Aleš; Barott, K. L.; Rohwer, F. L.; Keeling, P. J.

    2013-01-01

    Roč. 7, č. 2 (2013), s. 444-447. ISSN 1751-7362 Institutional support: RVO:60077344 Keywords : apicomplexan-related lineages * Chromera * coral symbionts * coral reef ecosystem Subject RIV: EH - Ecology, Behaviour Impact factor: 9.267, year: 2013

  14. Power station design and public relations - association with the citizen

    International Nuclear Information System (INIS)

    The series of questions concerning public relations, connected with the realization of power plant construction projects will be discussed before the background of the public requirement of electricity supply corporations. It will be explained that public relation cannot be seen as an instrument, having the purpose to inform about 'good or bad' of power plant designs and construction intentions. PR is more a constitutive element of economy policy. Transparent, clear information of the citizen about power plant projects, and power plant related procedures should be their targets. This signifies a distance from just technical presentation. PR must develop in the direction to active corporational strategy, taking psychological- and social psychological influences into consideration. Statements will be made in regard to the dialogue between power plant advocates and power plant opponents. The special responsibility of the public electricity supply corporations for an always sufficient, safe and economical supply to the consumer, will be pointed out. Better information of the public in this regard is a necessary requirement. (orig.)

  15. Compiler issues associated with safety-related software

    International Nuclear Information System (INIS)

    A critical issue in the quality assurance of safety-related software is the ability of the software to produce identical results, independent of the host machine, operating system, or compiler version under which the software is installed. A study is performed using the VIPRE-0l, FREY-01, and RETRAN-02 safety-related codes. Results from an IBM 3083 computer are compared with results from a CYBER 860 computer. All three of the computer programs examined are written in FORTRAN; the VIPRE code uses the FORTRAN 66 compiler, whereas the FREY and RETRAN codes use the FORTRAN 77 compiler. Various compiler options are studied to determine their effect on the output between machines. Since the Control Data Corporation and IBM machines inherently represent numerical data differently, methods of producing equivalent accuracy of data representation were an important focus of the study. This paper identifies particular problems in the automatic double-precision option (AUTODBL) of the IBM FORTRAN 1.4.x series of compilers. The IBM FORTRAN version 2 compilers provide much more stable, reliable compilation for engineering software. Careful selection of compilers and compiler options can help guarantee identical results between different machines. To ensure reproducibility of results, the same compiler and compiler options should be used to install the program as were used in the development and testing of the program

  16. Electrophysiological CNS-processes related to associative learning in humans.

    Science.gov (United States)

    Christoffersen, Gert R J; Schachtman, Todd R

    2016-01-01

    The neurophysiology of human associative memory has been studied with electroencephalographic techniques since the 1930s. This research has revealed that different types of electrophysiological processes in the human brain can be modified by conditioning: sensory evoked potentials, sensory induced gamma-band activity, periods of frequency-specific waves (alpha and beta waves, the sensorimotor rhythm and the mu-rhythm) and slow cortical potentials. Conditioning of these processes has been studied in experiments that either use operant conditioning or repeated contingent pairings of conditioned and unconditioned stimuli (classical conditioning). In operant conditioning, the appearance of a specific brain process is paired with an external stimulus (neurofeedback) and the feedback enables subjects to obtain varying degrees of control of the CNS-process. Such acquired self-regulation of brain activity has found practical uses for instance in the amelioration of epileptic seizures, Autism Spectrum Disorders (ASD) and Attention Deficit Hyperactivity Disorder (ADHD). It has also provided communicative means of assistance for tetraplegic patients through the use of brain computer interfaces. Both extra and intracortically recorded signals have been coupled with contingent external feedback. It is the aim for this review to summarize essential results on all types of electromagnetic brain processes that have been modified by classical or operant conditioning. The results are organized according to type of conditioned EEG-process, type of conditioning, and sensory modalities of the conditioning stimuli. PMID:26367470

  17. Kiikareissa kumppanuus : toimintaterapian rooli AVH-kuntoutujan kotiutusprosessissa

    OpenAIRE

    Lilius, Nora; Paso, Anni; Talvitie, Varpu

    2015-01-01

    Koska laitospaikkoja ollaan valtakunnallisesti vähentämässä, on sairaaloilla tarve kehittää kotiutusprosessejaan myös taloudellisesti kannattaviksi. Painetta lisää se, että väestörakenne on muuttumassa ikääntyneiden määrän kasvaessa, ja sen myötä myös aivoverenkiertohäiriöt lisääntyvät. Toimintaterapian asiakaslähtöisyydestä tehdyissä tutkimuksissa on todettu toimintaterapian asiakaslähtöisyyden olevan vain harvoin kriittisen arvioinnin kohteena, joten myös tätä aihetta on tarpeen tutkia enem...

  18. Relational coordination is associated with productivity in general practice: a survey and register based study

    DEFF Research Database (Denmark)

    Lundstrøm, Sanne Lykke; Edwards, Kasper; Reventlow, Susanne;

    2014-01-01

    In this paper we investigate the association between relational coordination among the practice team in general practice and number of consultations performed in a general practice per staff, i.e. a proxy of productivity. We measured relational coordination using the Relational Coordination Survey...... and combined the results with register data. We found that relational coordination was statistically significant associated with number of consultation per staff per year. We later divided consultations in to three types: Face-to-face, Email and phone consultations. We found a statistically...... significant associating between relational coordination and with number of face-to-face consultation per staff per year....

  19. Empathy-related Responding: Associations with Prosocial Behavior, Aggression, and Intergroup Relations

    OpenAIRE

    Eisenberg, Nancy; Eggum, Natalie D.; Di Giunta, Laura

    2010-01-01

    Empathy-related responding, including empathy, sympathy, and personal distress, has been implicated in conceptual models and theories about prosocial behavior and altruism, aggression and antisocial behavior, and intergroup relationships. Conceptual arguments and empirical findings related to each of these topics are reviewed. In general, there is evidence that empathy and/or sympathy are important correlates of, and likely contributors to, other-oriented prosocial behavior, the inhibition of...

  20. Malnutrition is associated with worse health-related quality of life in children with cancer

    NARCIS (Netherlands)

    Brinksma, Aeltsje; Sanderman, Robbert; Roodbol, Petrie F.; Sulkers, Esther; Burgerhof, Johannes G. M.; de Bont, Eveline S. J. M.; Tissing, Wim J. E.

    2015-01-01

    Malnutrition in childhood cancer patients has been associated with lower health-related quality of life (HRQOL). However, this association has never actually been tested. Therefore, we aimed to determine the association between nutritional status and HRQOL in children with cancer. In 104 children, a

  1. Spontaneous ARIA (Amyloid-Related Imaging Abnormalities) and Cerebral Amyloid Angiopathy Related Inflammation in Presenilin 1-Associated Familial Alzheimer's Disease

    OpenAIRE

    Ryan, N. S.; Lashley, T.; Revesz, T; Dantu, K.; Fox, N.C.; Morris, H R

    2014-01-01

    Amyloid-related imaging abnormalities (ARIA), thought to reflect immune responses to vascular amyloid, have been detected in several amyloid-modifying therapy trials for Alzheimer's disease (AD). We report a case of ARIA developing spontaneously during the course of Presenilin 1 (PSEN1)-associated familial AD (FAD), in an APOE4 homozygous patient. Severe cerebral amyloid angiopathy with associated inflammation was subsequently found at autopsy. Recognition that ARIA may arise spontaneously du...

  2. Associations between urban greenspace and health-related quality of life in children

    OpenAIRE

    McCracken, Deborah S.; Allen, Deonie A.; Gow, Alan J.

    2016-01-01

    With research to suggest that urban greenspace use can affect the health and wellbeing of adults, it is important to investigate this association in children. Compared with factors such as physical activity, research considering greenspace and its association with the health and wellbeing of children from urban areas is relatively rare. This study examined the health-related quality of life of 276 children residing in the city of Edinburgh in relation to quantity and use of greenspace. As muc...

  3. The processing of associations versus the processing of relations and symbols: A systematic comparison

    OpenAIRE

    Phillips, S; Halford, G. S.; Wilson, W H

    1995-01-01

    A mathematical basis is proposed for the distinction between associative and relational (symbolic) processing. Associations can be contrasted with relations in terms of ordered pairs versus general ordered N-tuples, and unidirectional access versus omnidirectional access. Relations also have additional properties: they can exhibit predicate-argument bindings, they can be arguments to higher-order structures, and they can participate in operations of selection, projection, join, union, interse...

  4. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

    Directory of Open Access Journals (Sweden)

    Angelo Scuteri

    2007-07-01

    Full Text Available The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of recent advances in gene-mapping technology, we executed a genome-wide association scan to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia. Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight. Within the FTO gene, rs9930506 showed the strongest association with BMI (p = 8.6 x10(-7, hip circumference (p = 3.4 x 10(-8, and weight (p = 9.1 x 10(-7. In Sardinia, homozygotes for the rare "G" allele of this SNP (minor allele frequency = 0.46 were 1.3 BMI units heavier than homozygotes for the common "A" allele. Within the PFKP gene, rs6602024 showed very strong association with BMI (p = 4.9 x 10(-6. Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12 were 1.8 BMI units heavier than homozygotes for the common "G" allele. To replicate our findings, we genotyped these two SNPs in the GenNet study. In European Americans (N = 1,496 and in Hispanic Americans (N = 839, we replicated significant association between rs9930506 in the FTO gene and BMI (p-value for meta-analysis of European American and Hispanic American follow-up samples, p = 0.001, weight (p = 0.001, and hip circumference (p = 0.0005. We did not replicate association between rs6602024 and obesity-related traits in the GenNet sample, although we found that in European Americans, Hispanic Americans, and African Americans, homozygotes for the rare "A" allele were, on average, 1.0-3.0 BMI units heavier than homozygotes for the more common "G" allele. In summary, we have completed a whole genome-association scan for

  5. Associations between urban greenspace and health-related quality of life in children.

    Science.gov (United States)

    McCracken, Deborah S; Allen, Deonie A; Gow, Alan J

    2016-06-01

    With research to suggest that urban greenspace use can affect the health and wellbeing of adults, it is important to investigate this association in children. Compared with factors such as physical activity, research considering greenspace and its association with the health and wellbeing of children from urban areas is relatively rare. This study examined the health-related quality of life of 276 children residing in the city of Edinburgh in relation to quantity and use of greenspace. As much of the existing research has employed parental reports of children's health, the current study assessed health-related quality of life via self-report, measured using the Kid-KINDL questionnaire (Ravens-Sieberer & Bullinger, 1998). Spatial analysis of greenspace quantity and typology was undertaken using mapping software, ArcGIS (Esri, 2011). In regression analysis, higher greenspace use and having fewer siblings were significantly associated with better health-related quality of life. Further analysis revealed that these variables were also associated with the 'friends' sub-scale score of the Kid-KINDL. Higher greenspace use was positively associated with 'self-esteem' sub-scale scores. However, the quantity of residential greenspace was not associated with the health-related quality of life of children. This study suggests that increased use of greenspace in urban areas might have a small but positive impact on child health-related quality of life, though future longitudinal and intervention studies are required to confirm these causal assumptions. PMID:27419017

  6. Associations between Neuroticism and Depression in Relation to Catastrophizing and Pain-Related Anxiety in Chronic Pain Patients.

    Directory of Open Access Journals (Sweden)

    Sandeep Kadimpati

    Full Text Available Several cognitive-affective constructs, including pain catastrophizing and pain-related anxiety, have been implicated in the onset and progression of chronic pain, and both constructs have been identified as key targets for multidisciplinary pain treatment. Both neuroticism and depression have been linked to these constructs (and to each other, but how each may contribute to the pain experience is unknown. This study tested associations between neuroticism, depression, and indices of catastrophizing and pain-related anxiety among persons seeking treatment for chronic non-malignant pain. We hypothesized, as a higher-order personality trait, neuroticism would remain uniquely associated with both pain catastrophizing and pain-related anxiety, even after accounting for current symptoms of depression. A retrospective study design assessed depression (as measured by the Centers for Epidemiologic Studies-Depression scale, neuroticism (measured with the Neuroticism-Extraversion-Openness Personality Inventory, the Pain Catastrophizing Scale, and the Pain Anxiety Symptom Score in a consecutive series of patients (n=595 admitted to a 3-week outpatient pain treatment program from March 2009 through January 2011. Hierarchical regression indicated that neuroticism was independently associated with greater pain catastrophizing and pain-related anxiety, above-and-beyond the contributions of sociodemographic characteristics, pain severity, and depression. A depression by neuroticism interaction was not observed, suggesting that associations between neuroticism and cognitive-affective pain constructs remained stable across varying levels of current depression. These findings represent an early but important step towards the clarification of complex associations between trait neuroticism, current depression, and tendencies toward catastrophic and anxiety-provoking appraisals of pain among persons seeking treatment for chronic pain.

  7. Health-Related Factors Associated with Mode of Travel to Work

    OpenAIRE

    Melissa Bopp; Kaczynski, Andrew T.; Matthew E. Campbell

    2013-01-01

    Active commuting (AC) to the workplace is a potential strategy for incorporating physical activity into daily life and is associated with health benefits. This study examined the association between health-related factors and mode of travel to the workplace. Methods. A volunteer convenience sample of employed adults completed an online survey regarding demographics, health-related factors, and the number of times/week walking, biking, driving, and using public transit to work (dichotomized as...

  8. No association between q-angle and foot posture with running-related injuries

    DEFF Research Database (Denmark)

    Jørgensen, Daniel Ramskov; Jensen, Majbritt Lykke; Obling, Kirstine Høj; Nielsen, Rasmus Østergaard; Parner, Erik Thorlund; Rasmussen, S

    2013-01-01

    There is a paucity of knowledge on the association between different foot posture quantified by Foot Posture Index (FPI) and Quadriceps angle (Q-angle) with development of running-related injuries. Earlier studies investigating these associations did not include an objective measure of the amount...

  9. Forest and Temperature Associations of Russia Relating to Global Climate Warming.

    OpenAIRE

    V. Stolbovoi; Nilsson, S.

    1999-01-01

    We have developed forest and temperature associations for Russia that relate forest communities of Russia with mean annual temperature, standard deviation of mean annual temperature, and temperature tolerance limits. These associations are derived from analysis of the frequency of forest occurrence in different temperature regimes, and were interpreted in order to develop a framework for adaptation strategies for Global Climate Warming (GCW).

  10. Cutaneous wart-associated HPV types: prevalence and relation with patient characteristics

    NARCIS (Netherlands)

    Bruggink, S.C.; Koning, M.N. de; Gussekloo, J.; Egberts, P.F.; Schegget, J. ter; Feltkamp, M.C.; Bavinck, J.N.; Quint, W.G.V.; Assendelft, W.J.J.; Eekhof, J.A.H.

    2012-01-01

    BACKGROUND: Epidemiological data on cutaneous wart-associated HPV types are rare. OBJECTIVES: To examine the prevalence of cutaneous wart-associated HPV types and their relation with patient characteristics. STUDY DESIGN: Swabs were taken from all 744 warts of 246 consecutive immunocompetent partici

  11. Voice Disorders in Teachers and Their Associations with Work-Related Factors: A Systematic Review

    Science.gov (United States)

    Cutiva, Lady Catherine Cantor; Vogel, Ineke; Burdorf, Alex

    2013-01-01

    Purpose: To provide a quantitative assessment of the occurrence of voice disorders among teachers and to identify associated work-related and individual factors in the teaching profession. Method: A systematic review was conducted using three computerized databases on the occurrence of voice disorders among teachers and their associations with…

  12. Associations between Neuroticism and Depression in Relation to Catastrophizing and Pain-Related Anxiety in Chronic Pain Patients

    OpenAIRE

    Kadimpati, Sandeep; Zale, Emily L.; Hooten, Michael W.; Ditre, Joseph W.; Warner, David O.

    2015-01-01

    Several cognitive-affective constructs, including pain catastrophizing and pain-related anxiety, have been implicated in the onset and progression of chronic pain, and both constructs have been identified as key targets for multidisciplinary pain treatment. Both neuroticism and depression have been linked to these constructs (and to each other), but how each may contribute to the pain experience is unknown. This study tested associations between neuroticism, depression, and indices of catastr...

  13. Neural correlates of relational memory: successful encoding and retrieval of semantic and perceptual associations

    NARCIS (Netherlands)

    S.E. Prince; S.M. Daselaar; R. Cabeza

    2005-01-01

    Using event-related functional magnetic resonance imaging, we identified brain regions involved in successful relational memory (RM) during encoding and retrieval for semantic and perceptual associations or in general, independent of phase and content. Participants were scanned while encoding and la

  14. PS3-19: The Association Between Body Mass Index and Intestinal Stoma-Related Problems

    OpenAIRE

    Skeps, Raymond; Herrinton, Lisa; McMullen, Carmit; Wendel, Christopher; Bulkley, Joanna; Krouse, Robert

    2010-01-01

    Background: Colorectal cancer (CRC) survivors with an intestinal stoma (or ostomy) may have multiple problems related to their stoma. Some evidence suggests that weight change is linked to increased problems with an ostomy. Aim: To examine the association between BMI and stoma-related problems in a sample of long-term (>5 years post-diagnosis) CRC survivors that received an ostomy.

  15. Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson's disease

    DEFF Research Database (Denmark)

    van Eimeren, Thilo; Binkofski, Ferdinand; Buhmann, Carsten;

    2010-01-01

    Treatment-related motor complications such as dyskinesias are a major problem in the long-term management of Parkinson's disease (PD). In sporadic PD, a relatively early onset of the disease is known to be associated with an early development of dyskinesias. Although linked with early onset...

  16. I owe you: age-related similarities and differences in associative memory for gains and losses.

    Science.gov (United States)

    Castel, Alan D; Friedman, Michael C; McGillivray, Shannon; Flores, Cynthia C; Murayama, Kou; Kerr, Tyson; Drolet, Aimee

    2016-09-01

    Older adults often experience associative memory impairments but can sometimes remember important information. The current experiments investigate potential age-related similarities and differences associate memory for gains and losses. Younger and older participants were presented with faces and associated dollar amounts, which indicated how much money the person "owed" the participant, and were later given a cued recall test for the dollar amount. Experiment 1 examined face-dollar amount pairs while Experiment 2 included negative dollar amounts to examine both gains and losses. While younger adults recalled more information relative to older adults, both groups were more accurate in recalling the correct value associated with high-value faces compared to lower-value faces and remembered gist-information about the values. However, negative values (losses) did not have a strong impact on recall among older adults versus younger adults, illustrating important associative memory differences between younger and older adults. PMID:26847137

  17. Variables associated with peripherally inserted central catheter related infection in high risk newborn infants 1

    OpenAIRE

    Uesliz Vianna Rangel; Saint Clair dos Santos Gomes Junior; Ana Maria Aranha Magalhães Costa; Maria Elisabeth Lopes Moreira

    2014-01-01

    OBJECTIVE: to relate the variables from a surveillance form for intravenous devices in high risk newborn infants with peripherally inserted central catheter related infection. METHODOLOGY: approximately 15 variables were studied, being associated with peripherally inserted central catheter related infection, this being defined by blood culture results. The variables analyzed were obtained from the surveillance forms used with intravenous devices, attached to the medical records of newborn inf...

  18. Perceived problems with computer gaming and Internet use are associated with poorer social relations in adolescence

    DEFF Research Database (Denmark)

    Rasmussen, Mette; Meilstrup, Charlotte Riebeling; Bendtsen, Pernille;

    2015-01-01

    OBJECTIVES: Young people's engagement in electronic gaming and Internet communication have caused concerns about potential harmful effects on their social relations, but the literature is inconclusive. The aim of this paper was to examine whether perceived problems with computer gaming and Internet...... communication are associated with young people's social relations. METHODS: Cross-sectional questionnaire survey in 13 schools in the city of Aarhus, Denmark, in 2009. Response rate 89 %, n = 2,100 students in grades 5, 7, and 9. Independent variables were perceived problems related to computer gaming...... and Internet use, respectively. Outcomes were measures of structural (number of days/week with friends, number of friends) and functional (confidence in others, being bullied, bullying others) dimensions of student's social relations. RESULTS: Perception of problems related to computer gaming were associated...

  19. Association of hair iron levels with creativity and psychological variables related to creativity

    OpenAIRE

    Hikaru Takeuchi

    2013-01-01

    Creativity generally involves the conception of original and valuable ideas. Previous studies have suggested an association between creativity and the dopaminergic system, and that physical activity facilitates creativity. Iron plays a key role in the dopaminergic system and physical activity. Here, we newly investigated the associations between hair iron levels and creativity, dopamine-related traits and states [novelty seeking, extraversion, and vigor (motivational state)], as well as the p...

  20. Social Relations and Health : How do the associations vary across contexts and subgroups of individuals?

    OpenAIRE

    Bergh, Daniel

    2011-01-01

    Objectives: The aim of this thesis is to study the association between social relations and health in different social spheres, and to examine possible interaction effects. Material and Methods: In Paper I, the link between measures of the psychosocial neighbourhood environment, the psychosocial working environment, and psychosomatic health is analyzed by using a subset of data from the survey Life and Health 2000. In Paper II, the association between adolescent social relationships in school...

  1. Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration

    OpenAIRE

    Tilleul, Julien; Richard, Florence; Puche, Nathalie; Zerbib, Jennyfer; Leveziel, Nicolas; Sahel, Jose Alain; Cohen, Salomon Yves; Korobelnik, Jean-Francois; Feingold, Josue; Munnich, Arnold; Kaplan, Josseline; Rozet, Jean-Michel; Souied, Eric H.

    2013-01-01

    Purpose Age-related macular degeneration (AMD) is a multifactorial disease involving genetic and environmental factors. Most of the genetic factors identified so far involve the nuclear genome. Recently, two studies in North America and Australia reported an association between advanced AMD and the mitochondrial T2 haplogroup. Our purpose was to assess this association in a large French population. Methods This case control study included 1,224 patients with neovascular AMD and 559 controls w...

  2. From expression pattern to genetic association in asthma and asthma-related phenotypes

    Directory of Open Access Journals (Sweden)

    Vaillancourt Vanessa T

    2012-11-01

    Full Text Available Abstract Background Asthma is a complex disease characterized by hyperresponsiveness, obstruction and inflammation of the airways. To date, several studies using different approaches as candidate genes approach, genome wide association studies, linkage analysis and genomic expression leaded to the identification of over 300 genes involved in asthma pathophysiology. Combining results from two studies of genomic expression, this study aims to perform an association analysis between genes differently expressed in bronchial biopsies of asthmatics compared to controls and asthma-related phenotypes using the same French-Canadian Caucasian population. Results Before correction, 31 of the 85 genes selected were associated with at least one asthma-related phenotype. We found four genes that survived the correction for multiple testing. The rs11630178 in aggrecan gene (AGC1 is associated with atopy (p=0.0003 and atopic asthma (p=0.0001, the rs1247653 in the interferon alpha-inducible protein 6 (IFI6, the rs1119529 in adrenergic, alpha-2A-, receptor (ADRA2A and the rs13103321 in the alcohol dehydrogenase 1B (class I, beta polypeptide (ADH1B, are associated with asthma (p=0.019; 0.01 and 0.002 respectively. Conclusion To our knowledge, this is the first time those genes are associated with asthma and related traits. Consequently, our study confirms that genetic and expression studies are complementary to identify new candidate genes and to investigate their role to improve the comprehension of the complexity of asthma pathophysiology.

  3. Three term recursion relation for spherical functions associated to the complex hyperbolic plane

    International Nuclear Information System (INIS)

    The symmetric space duality between the complex hyperbolic plane H2(C)=SU(2, 1/U(2) and the complex projective plane P2(C) = SU(3)/U(2) also becomes apparent in the theory of matrix valued spherical functions associated to both spaces. This is stressed in this paper by proving a three term recursion relation for a family of matrix valued functions built up from the spherical functions associated to H2(C). In a very precise sense this extends the three term recursion relation which holds for P2(C). (author)

  4. Rickettsial relative associated with male-killing in the ladybird beetle (Adalia bipunctata).

    OpenAIRE

    Werren, J.H.; Hurst, G.G.D.; Zhang, W.; Breeuwer, J.A.J.; Stouthamer, R; Majerus, M. E. N.

    1994-01-01

    A cytoplasmically inherited microorganism associated with male killing in the two-spot ladybird beetle, Adalia bipunctata, is shown to be closely related to bacteria in the genus Rickettsia. Sequencing of a PCR-amplified product of the 16S genes coding for rRNA (16S rDNA) shows the organism associated with male killing in ladybirds to share a common ancestry with the Rickettsias relative to other genera (e.g., Anaplasma, Ehrlichia, and Cowdria). The rickettsial 16S rDNA product is found in fo...

  5. Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations.

    Directory of Open Access Journals (Sweden)

    Christine E McLaren

    Full Text Available The existence of multiple inherited disorders of iron metabolism suggests genetic contributions to iron deficiency. We previously performed a genome-wide association study of iron-related single nucleotide polymorphisms (SNPs using DNA from white men aged ≥ 25 y and women ≥ 50 y in the Hemochromatosis and Iron Overload Screening (HEIRS Study with serum ferritin (SF ≤ 12 µg/L (cases and controls (SF >100 µg/L in men, SF >50 µg/L in women. We report a follow-up study of white, African-American, Hispanic, and Asian HEIRS participants, analyzed for association between SNPs and eight iron-related outcomes. Three chromosomal regions showed association across multiple populations, including SNPs in the TF and TMPRSS6 genes, and on chromosome 18q21. A novel SNP rs1421312 in TMPRSS6 was associated with serum iron in whites (p = 3.7 × 10(-6 and replicated in African Americans (p = 0.0012.Twenty SNPs in the TF gene region were associated with total iron-binding capacity in whites (p<4.4 × 10(-5; six SNPs replicated in other ethnicities (p<0.01. SNP rs10904850 in the CUBN gene on 10p13 was associated with serum iron in African Americans (P = 1.0 × 10(-5. These results confirm known associations with iron measures and give unique evidence of their role in different ethnicities, suggesting origins in a common founder.

  6. Error-related electromyographic activity over the corrugator supercilii is associated with neural performance monitoring.

    Science.gov (United States)

    Elkins-Brown, Nathaniel; Saunders, Blair; Inzlicht, Michael

    2016-02-01

    Emerging research in social and affective neuroscience has implicated a role for affect and motivation in performance monitoring and cognitive control. No study, however, has investigated whether facial electromyography (EMG) over the corrugator supercilii-a measure associated with negative affect and the exertion of effort-is related to neural performance monitoring. Here, we explored these potential relationships by simultaneously measuring the error-related negativity, error positivity (Pe), and facial EMG over the corrugator supercilii muscle during a punished, inhibitory control task. We found evidence for increased facial EMG activity over the corrugator immediately following error responses, and this activity was related to the Pe for both between- and within-subject analyses. These results are consistent with the idea that early, avoidance-motivated processes are associated with performance monitoring, and that such processes may also be related to orienting toward errors, the emergence of error awareness, or both. PMID:26470645

  7. The Association between IT Related Trainings and IT Investments in Malaysia

    OpenAIRE

    Marjan Mohd Noor; Kogilavani Apadore

    2013-01-01

    This study aims to examine whether there are association between IT related trainings and IT investments in theMalaysian technology-based companies. This study uses two types of IT related trainings namely intermediate ITtrainings, and advanced IT trainings which have never been tested with IT investments in previous studies. Thedata were collected via annual reports in 2010 from 104 technology-based companies listed in Bursa Malaysia.Results from univariate test show that IT-based companies ...

  8. Are mental health problems associated with use of Accident and Emergency and health-related harm?

    OpenAIRE

    Keene, Jan; Rodriguez, Jorge

    2007-01-01

    Background: Previous findings indicate that mental health problems are common in Emergency departments; however, there are few studies of the extent of health-related problems and emergency service use in mental health populations as a whole. Methods: Record linkage methods were used to map the association between mental health, age, gender, and health-related harm across total health and mental health care populations in one geographical area, over three years. By examining patterns of healt...

  9. Association of Relatives of Hemodialysis Patients with Metabolic Syndrome, Albuminuria and Framingham Risk Score

    OpenAIRE

    Huang, Jiun-Chi; Chen, Szu-Chia; Lin, Ming-Yen; Chang, Jer-Ming; Hwang, Shang-Jyh; Tsai, Jer-Chia; Chen, Hung-Chun

    2014-01-01

    Background and Aim Metabolic syndrome (MetS), albuminuria, and the Framingham Risk Score (FRS) are significant predictors for cardiovascular disease (CVD). However, the relationship and clinical significance of these CVD predictors in individuals with a family history of end-stage renal disease (ESRD) are unclear. We investigated the association of relatives of hemodialysis (HD) patients with MetS, albuminuria, and the FRS. Methods One hundred and sixty-six relatives of HD patients and 374 ag...

  10. An event-related brain potential study of schizotypal personality and associative semantic processing

    OpenAIRE

    Kiang, Michael; Prugh, Jocelyn; Kutas, Marta

    2009-01-01

    To examine whether schizotypal personality is associated with the degree to which concepts activate each other in semantic memory, event-related brain potentials (ERPs) were recorded during a delayed lexical decision task from healthy volunteers rated for schizotypy. Each target word was directly, indirectly, or not at all related to a prime word preceding it at a 300- or 750-ms stimulus-onset asynchrony (SOA). Overall, N400 amplitudes were largest for unrelated targets, smallest for directly...

  11. Hippocampus's role in forming "task-related" associations: Flashing to the things you are looking for

    Institute of Scientific and Technical Information of China (English)

    ZHANG XiuLing; NIKI Kazuhisa; LUO Jing

    2008-01-01

    Eichenbaum and colleagues observed that the same place did or did not activate the "goal-approach" cells in hippocampus depending on whether the place was the way for rata to approach specific goal.Parallel with this,the present neuroimage study revealed that,the same type of items could activate the hippocampus more when it was related to the task at hand than when it not.Participants were scanned by fMRI while they made judgments on the type of relationships contained in the word-pairs (e.g.,Does the word pair,"furniture-table",contain a "category-exemplar" relationship?).Event-related analysis revealed that the forming of "task-related" association activated hippocampus more than that of "task-unrelated",even if it was the same type of items,and,this hippocampsl difference was not caused by the different judgment requirements,nor by the effects of "yes" response.Consistently,the post-judgment cued-recall test exhibited a better retrieval performance for "task-related" associations than for the same type but "task-unrelated" associations.Results also showed that,the semantic re-latedness between the to-be-associated individual words (e.g.,the related word pair "healthy-hospital"versus the unrelated word pair "price-way") was not enough to activate the hippocampus when it was"task-unrelated".Generally,we proposed that,through participating in forming of "task-related" asso-ciations and consolidating of episodic memory,hippocampus enabled the organism to keep the in-formation that owned great survival values in mind for future usage.

  12. Association of Genetic Variation in ENPP1 With Obesity-related Phenotypes

    Science.gov (United States)

    Jenkinson, Christopher P.; Coletta, Dawn K.; Flechtner-Mors, Marion; Hu, Shirley L.; Fourcaudot, Marcel J.; Rodriguez, Lenore M.; Schneider, Jennifer; Arya, Rector; Stern, Michael P.; Blangero, John; Duggirala, Ravindranath; DeFronzo, Ralph A.

    2016-01-01

    Ectonucleotide pyrophosphatase phosphodiesterase (ENPP1) is a positional candidate gene at chromosome 6q23 where we previously detected strong linkage with fasting-specific plasma insulin and obesity in Mexican Americans from the San Antonio Family Diabetes Study (SAFDS). We genotyped 106 single-nucleotide polymorphisms (SNPs) within ENPP1 in all 439 subjects from the linkage study, and measured association with obesity and metabolic syndrome (MS)-related traits. Of 72 polymorphic SNPs, 24 were associated, using an additive model, with at least one of eight key metabolic traits. Three traits were associated with at least four SNPs. They were high-density lipoprotein cholesterol (HDL-C), leptin, and fasting plasma glucose (FPG). HDL-C was associated with seven SNPs, of which the two most significant P values were 0.0068 and 0.0096. All SNPs and SNP combinations were analyzed for functional contribution to the traits using the Bayesian quantitative-trait nucleotide (BQTN) approach. With this SNP-prioritization analysis, HDL-C was the most strongly associated trait in a four-SNP model (P = 0.00008). After accounting for multiple testing, we conclude that ENPP1 is not a major contributor to our previous linkage peak with MS-related traits in Mexican Americans. However, these results indicate that ENPP1 is a genetic determinant of these traits in this population, and are consistent with multiple positive association findings in independent studies in diverse human populations. PMID:18464750

  13. Strategies to Prevent Positioning-Related Complications Associated with the Lateral Suboccipital Approach

    OpenAIRE

    Furuno, Yuichi; SASAJIMA, HIROYASU; Goto, Yukihiro; Taniyama, Ichita; Aita, Kazuyasu; OWADA, KEI; Tatsuzawa, Kazunori; Mineura, Katsuyoshi

    2013-01-01

    The lateral positioning used for the lateral suboccipital surgical approach is associated with various pathophysiologic complications. Strategies to avoid complications including an excessive load on the cervical vertebra and countermeasures against pressure ulcer development are needed. We retrospectively investigated positioning-related complications in 71 patients with cerebellopontine angle lesions undergoing surgery in our department between January 2003 and December 2010 using the later...

  14. Polyclonal hyperviscosity syndrome in IgG4-related disease and associated conditions

    OpenAIRE

    Chen, Luke YC; Wong, Patrick CW; Noda, Shinji; Collins, David R.; Sreenivasan, Gayatri M; Coupland, Robert C

    2015-01-01

    Key Clinical Message Polyclonal hyperviscosity syndrome (HVS) is rare and has been reported in various disorders of immune dysregulation and lymphoid hyperplasia. IgG4-Related Disease (IgG4-RD) is an emerging disorder often associated with exuberant hypergammaglobulinemia, and this review of seven cases establishes IgG4-RD as an important cause of polyclonal HVS.

  15. Mothers' Cognitions about Relational Aggression: Associations with Discipline Responses, Children's Normative Beliefs, and Peer Competence

    Science.gov (United States)

    Werner, Nicole E.; Grant, Samantha

    2009-01-01

    Prior research has shown that parental social cognitions are associated with child outcomes such as aggression. The goal of this study was to examine mothers' cognitions about relational aggression, and to explore linkages between mothers' attributions and normative beliefs about aggression and children's competence with peers. Participants…

  16. ADHD Related Behaviors Are Associated with Brain Activation in the Reward System

    Science.gov (United States)

    Stark, R.; Bauer, E.; Merz, C. J.; Zimmermann, M.; Reuter, M.; Plichta, M. M.; Kirsch, P.; Lesch, K. P.; Fallgatter, A. J.; Vaitl, D.; Herrmann, M. J.

    2011-01-01

    Neuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) suggest dysfunctional reward processing, with hypo-responsiveness during reward anticipation in the reward system including the nucleus accumbens (NAcc). In this study, we investigated the association between ADHD related behaviors and the reward system using functional…

  17. Developmental Trajectories of Chinese Children's Relational and Physical Aggression: Associations with Social-Psychological Adjustment Problems

    Science.gov (United States)

    Kawabata, Yoshito; Tseng, Wan-Ling; Murray-Close, Dianna; Crick, Nicki R.

    2012-01-01

    The purpose of this short-term longitudinal study was to examine Chinese children's trajectories of physical and relational aggression and their association with social-psychological adjustment problems (i.e., depressive symptoms and delinquency) and gender. Fourth and fifth grade children in Taiwan (n = 739, age 9-11) were followed across 1 year.…

  18. Voice disorders in teachers and their associations with work-related factors : A systematic review

    NARCIS (Netherlands)

    Cutiva, Lady Catherine Cantor; Vogel, Ineke; Burdorf, Alex

    2013-01-01

    Purpose: To provide a quantitative assessment of the occurrence of voice disorders among teachers and to identify associated work-related and individual factors in the teaching profession. Method: A systematic review was conducted using three computerized databases on the occurrence of voice disorde

  19. Peer Relations and the Understanding of Faux Pas: Longitudinal Evidence for Bidirectional Associations

    Science.gov (United States)

    Banerjee, Robin; Watling, Dawn; Caputi, Marcella

    2011-01-01

    Research connecting children's understanding of mental states to their peer relations at school remains scarce. Previous work by the authors demonstrated that children's understanding of mental states in the context of a faux pas--a social blunder involving unintentional insult--is associated with concurrent peer rejection. The present report…

  20. Association between religiousness and blood donation among Brazilian postgraduate students from health-related areas

    Directory of Open Access Journals (Sweden)

    Edson Zangiacomi Martinez

    2014-06-01

    Full Text Available OBJECTIVE: The aim of this study was to examine the association between religiousness and blood donation among postgraduate students.METHODS: The Portuguese-language version of the Duke University Religion Index was administered to a sample of 226 Brazilian students with ages ranging from 22 to 55 years. All study participants had completed undergraduate courses in health-related areas.RESULTS: In the present study, 23.5% of the students were regular donors. Organizational religiousness was found to be associated with attitudes related to blood donation. This study also shows evidence that regular blood donors have a higher intrinsic religiousness than subjects who donate only once and do not return.CONCLUSION: This study shows that the attitudes concerning blood donation may have some association with religiosity.

  1. Fluid mechanics simulation of fog formation associated with polluted atmosphere produced by energy related fuel combustion

    Science.gov (United States)

    Hung, R. J.; Liaw, G. S.

    1980-01-01

    It is noted that large quantities of atmospheric aerosols with composition SO4(-2), NO3(-1), and NH4(+1) have been detected in highly industrialized areas. Most aerosol products come from energy-related fuel combustion. Fluid mechanics simulation of both microphysical and macrophysical processes is considered in studying the time dependent evolution of the saturation spectra of condensation nuclei associated with polluted and clean atmospheres during the time periods of advection fog formation. The results demonstrate that the condensation nuclei associated with a polluted atmosphere provide more favorable conditions than condensation nuclei associated with a clean atmosphere to produce dense advection fog, and that attaining a certain degree of supersaturation is not necessarily required for the formation of advection fog having condensation nuclei associated with a polluted atmosphere.

  2. Are food-related perceptions associated with meal portion size decisions? A cross-sectional study.

    Science.gov (United States)

    Spence, Michelle; Stancu, Violeta; Dean, Moira; Livingstone, M Barbara E; Gibney, Eileen R; Lähteenmäki, Liisa

    2016-08-01

    The purpose of this study was to test a comprehensive model of meal portion size determinants consisting of sociodemographic, psychological and food-related variables, whilst controlling for hunger and thirst. Using cross-sectional nationally representative data collected in 2075 participants from the Island of Ireland (IoI) and Denmark (DK), eight separate hierarchical multiple regression analyses were conducted to examine the association between food-related variables and meal portion size (i.e. pizza, vegetable soup, chicken salad and a pork meal) within each country. Stepwise regressions were run with physiological control measures (hunger and thirst) entered in the first step, sociodemographic variables (sex, age, body mass index (BMI)) in the second step; psychological variables (cognitive restraint, uncontrolled eating, emotional eating, general health interest (GHI)) in the third step and food-related variables (expected fillingness, liking, expected healthfulness, food familiarity) in the fourth step. Sociodemographic variables accounted for 2-19% of the variance in meal portion sizes; psychological variables explained an additional 3-8%; and food-related variables explained an additional 2-12%. When all four variable groups were included in the regression models, liking and sometimes expected healthfulness was positively associated with meal portion size. The strongest association was for liking, which was statistically significant in both countries for all meal types. Whilst expected healthfulness was not associated with pizza portion size in either country, it was positively associated with meals that have a healthier image (vegetable soup; chicken salad and in IoI, the pork meal). In conclusion, after considering sociodemographic and psychological variables, and the food-related variables of liking and expected healthfulness, there may be little merit in manipulating the satiating power, at least of these type of meals, to maintain or promote weight

  3. Health-Related Factors Associated with Mode of Travel to Work

    Directory of Open Access Journals (Sweden)

    Melissa Bopp

    2013-01-01

    Full Text Available Active commuting (AC to the workplace is a potential strategy for incorporating physical activity into daily life and is associated with health benefits. This study examined the association between health-related factors and mode of travel to the workplace. Methods. A volunteer convenience sample of employed adults completed an online survey regarding demographics, health-related factors, and the number of times/week walking, biking, driving, and using public transit to work (dichotomized as no walk/bike/drive/PT and walk/bike/drive/PT 1 + x/week. Logistic regression was used to predict the likelihood of each mode of transport and meeting PA recommendations from AC according to demographics and health-related factors. Results. The sample was aged 43.5 11.4 years and was primarily White (92.7% and female (67.9%. Respondents reported walking (7.3%, biking (14.4%, taking public transit (20.3%, and driving (78.3% to work at least one time/week. Among those reporting AC, 9.6% met PA recommendations from AC alone. Mode of travel to work was associated with several demographic and health-related factors, including age, number of chronic diseases, weight status, and AC beliefs. Discussion. Mode of transportation to the workplace and health-related factors such as disease or weight status should be considered in future interventions targeting AC.

  4. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

    Directory of Open Access Journals (Sweden)

    Carsten A Böger

    2011-09-01

    Full Text Available Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD and end stage renal disease (ESRD. Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR <60ml/min/1.73m(2 at follow-up and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls. SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1. SNPs in UMOD (OR = 0.92, p = 0.04 and GCKR (OR = 0.93, p = 0.03 were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.

  5. On discrete three-dimensional equations associated with the local Yang-Baxter relation

    Science.gov (United States)

    Kashaev, R. M.

    1996-12-01

    The local Yang-Baxter equation (YBE), introduced by Maillet and Nijhoff, is a proper generalization to three dimensions of the zero curvature relation. Recently, Korepanov has constructed an infinite set of integrable three-dimensional lattice models, and has related them to solutions to the local YBE. The simplest Korepanov model is related to the star-triangle relation in the Ising model. In this Letter the corresponding discrete equation is derived. In the continuous limit it leads to a differential three-dimensional equation, which is symmetric with respect to all permutations of the three coordinates. A similar analysis of the star-triangle transformation in electric networks leads to the discrete bilinear equation of Miwa, associated with the BKP hierarchy. Some related operator solutions to the tetrahedron equation are also constructed.

  6. Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.

    Science.gov (United States)

    Emami, Nashmil; Scorilas, Andreas; Soosaipillai, Antoninus; Earle, Tammy; Mullen, Brendan; Diamandis, Eleftherios P

    2009-09-01

    Human kallikrein-related peptidases (KLKs) are a family of proteases, the majority of which are found in seminal plasma and have been implicated in semen liquefaction. Here, we examined the clinical value of seminal KLKs in the evaluation of semen quality and differential diagnosis and etiology of abnormal liquefaction and/or viscosity. KLK1-3, 5-8, 10, 11, 13, and 14 were analyzed, using highly specific ELISA assays. Samples were categorized into four clinical groups, according to their state of liquefaction and viscosity. Data were compared between the clinical groups and in association with other parameters of sperm quality, including number of motile sperms, straight line speed, sperm concentration, volume, pH, and patient age. Seminal KLKs were found to be differentially expressed in the four clinical groups. Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 showed very strong discriminatory potential for semen liquefaction and viscosity, respectively. Liquefaction state was associated with several parameters of sperm motility. Finally, KLK14 was differentially expressed in asthenospermic cases. In conclusion, the expression level of several seminal plasma KLKs correlates with liquefaction and viscosity indicators of semen quality and may aid in their differential diagnosis and etiology. PMID:19558318

  7. The association between self-esteem and happiness differs in relationally mobile vs. stable contexts

    Directory of Open Access Journals (Sweden)

    Kosuke eSato

    2014-10-01

    Full Text Available Does a change in the nature of surrounding social context affect the strength of association between self-esteem and happiness? This paper aims to answer this question from a socio-ecological perspective, focusing on the role of relational mobility. Recent research has shown that this association is stronger in societies that are higher in relational mobility, where there is a greater freedom of choice in interpersonal relationships and group memberships. In this study, we tested if this hypothesis could be applied to situational differences within the same physical setting. Using a quasi-experimental design, we tested if the association between self-esteem and happiness was stronger for first-year students at a Japanese university who had just entered the college and thus were in a relatively higher mobility context, than the second year students at the same university whose relationships tended to be more stable and long-standing. The results showed, as predicted, that the association between self-esteem and happiness was stronger for the first-year students than for the second-year students. Implications for the theory and research on social change are discussed.

  8. Coaches' implicit associations between size and giftedness: implications for the relative age effect.

    Science.gov (United States)

    Furley, Philip; Memmert, Daniel

    2016-01-01

    The relative age effect (RAE) is a well-established phenomenon in education and sports. Coaches have been assumed to be important social agents of RAE via biased selection decisions in favour of children with maturation advantages. In the present research, we used the Implicit Association Test to investigate automatic associations between body size and a player's domain-specific giftedness amongst youth baseball (N = 18) and youth soccer coaches (N = 34). We found medium to strong automatic associations between body size and player giftedness (baseball: MD = 0.62; soccer: MD = 0.51). Specifically, taller players were associated with positive performance-related attributes, whereas smaller players were associated with negative attributes. The results are in line with theories of grounded cognition by showing that the abstract concept of "sport giftedness" is partly grounded in the perception of physical height amongst youth sports coaches. We argue that this grounded cognition has the potential to influence coaches' selection decisions and in turn account for RAE as coaches are biased towards physically more matured players, even when no apparent performance advantage is evident. PMID:26096053

  9. Sharing self-related information is associated with intrinsic functional connectivity of cortical midline brain regions.

    Science.gov (United States)

    Meshi, Dar; Mamerow, Loreen; Kirilina, Evgeniya; Morawetz, Carmen; Margulies, Daniel S; Heekeren, Hauke R

    2016-01-01

    Human beings are social animals and they vary in the degree to which they share information about themselves with others. Although brain networks involved in self-related cognition have been identified, especially via the use of resting-state experiments, the neural circuitry underlying individual differences in the sharing of self-related information is currently unknown. Therefore, we investigated the intrinsic functional organization of the brain with respect to participants' degree of self-related information sharing using resting state functional magnetic resonance imaging and self-reported social media use. We conducted seed-based correlation analyses in cortical midline regions previously shown in meta-analyses to be involved in self-referential cognition: the medial prefrontal cortex (MPFC), central precuneus (CP), and caudal anterior cingulate cortex (CACC). We examined whether and how functional connectivity between these regions and the rest of the brain was associated with participants' degree of self-related information sharing. Analyses revealed associations between the MPFC and right dorsolateral prefrontal cortex (DLPFC), as well as the CP with the right DLPFC, the left lateral orbitofrontal cortex and left anterior temporal pole. These findings extend our present knowledge of functional brain connectivity, specifically demonstrating how the brain's intrinsic functional organization relates to individual differences in the sharing of self-related information. PMID:26948055

  10. Neurologist-associated reduction in PD-related hospitalizations and health care expenditures

    Science.gov (United States)

    Schootman, Mario; Tran, Rebecca; Kung, Nathan; Evanoff, Bradley A.; Perlmutter, Joel S.; Racette, Brad A.

    2012-01-01

    Objective: To investigate the impact of neurologist care on Parkinson disease (PD)–related hospitalizations. Recent data indicate that neurologist treatment in PD may be associated with improved survival, yet is underutilized. Factors contributing to this improved survival remain unknown, but may be due in part to optimal disease treatment or avoidance of disease-related complications. Methods: This was a retrospective cohort study of Medicare beneficiaries diagnosed with PD in 2002 and still living in 2006. Hospitalization for PD-related (neurodegenerative disease, psychosis, depression, urinary tract infection, and traumatic injury) and general medical (hypertension, diabetes, congestive heart failure, angina, and gastrointestinal obstruction) illnesses was compared by PD treating physician specialty using Cox proportional hazard models, adjusting for confounders. Secondary analyses included PD-related rehospitalization and cost stratified by frequency of neurologist care. Results: We identified 24,929 eligible incident PD cases; 13,489 had neurologist care. There were 9,112 PD-related hospitalizations, and these occurred and recurred less often among neurologist-treated patients. Neurologist PD care was associated with lower adjusted odds of both initial and repeat hospitalization for psychosis (hazard ratio [HR] 0.71, 95% confidence interval [CI] 0.59–0.86), urinary tract infection (HR 0.74, 0.63–0.87), and traumatic injury (HR 0.56, 0.40–0.78). PD-related outcomes improved with frequency of neurologist care in a stepwise manner. Odds of general illness hospitalization or hospitalization did not differ by neurologist involvement. Conclusions: Regular neurologist care in PD is specifically associated with lower risk of hospitalization and rehospitalization for several PD-related illnesses. This may reflect an improved ability of neurologists to prevent, recognize, or treat PD complications. PMID:23054239

  11. Eponyms related to genetic disorders associated with gingival enlargement; part II

    Directory of Open Access Journals (Sweden)

    Nora Mohammed Al-Aboud

    2015-01-01

    Full Text Available There are genetic disorders associated with gingival enlargement. In our part I, we reviewed the eponyms linked to Hereditary Gingival Fibromatosis (HGF [1]. Historical Article How to cite this article: Al Aboud A, Al-Aboud NM, Barnawi H, Al Hakami A. Eponyms related to genetic disorders associated with gingival enlargement: Part II. Our Dermatol Online. 2015;6(1:114-117. Submission: 27.05.2013; Acceptance: 21.09.2014 DOI: 10.7241/ourd.20151.32 In this part II of this review, we are going to shed some light on eponyms linked to groups of genetic disorders which may feature gingival enlargement.

  12. Eponyms related to genetic disorders associated with gingival enlargement; part II

    OpenAIRE

    Nora Mohammed Al-Aboud; Hanan Barnawi; Ahlam Al Hakami

    2015-01-01

    There are genetic disorders associated with gingival enlargement. In our part I, we reviewed the eponyms linked to Hereditary Gingival Fibromatosis (HGF) [1]. Historical Article How to cite this article: Al Aboud A, Al-Aboud NM, Barnawi H, Al Hakami A. Eponyms related to genetic disorders associated with gingival enlargement: Part II. Our Dermatol Online. 2015;6(1):114-117. Submission: 27.05.2013; Acceptance: 21.09.2014 DOI: 10.7241/ourd.20151.32 In this part II of thi...

  13. Relational Coordination and Organisational Social Capital Association with Characteristics of General Practice

    DEFF Research Database (Denmark)

    Lundstrøm, Sanne Lykke; Edwards, Kasper; Bøllingtoft Knudsen, Thomas;

    2014-01-01

    Background. Relational coordination (RC) and organisational social capital (OSC) aremeasures of novel aspects of an organisation’s performance, which have not previously been analysed together, in general practice. Objectives.The aim of this studywas to analyse the associations between RC and OSC......, and characteristics of general practice. Methods. Questionnaire survey study comprising 2074 practices in Denmark. Results. General practitioners (GPs) rated both RC and OSC in their general practice higher than their secretaries and nurses. The practice form was statistically significantly associated...

  14. Relative entropy: Free energy associated with equilibrium fluctuations and nonequilibrium deviations

    Science.gov (United States)

    Qian, Hong

    2001-04-01

    Using a one-dimensional macromolecule in aqueous solution as an illustration, we demonstrate that the relative entropy from information theory, ∑kpk ln(pk/p*k), has a natural role in the energetics of equilibrium and nonequilibrium conformational fluctuations of the single molecule. It is identified as the free energy difference associated with a fluctuating density in equilibrium, and is associated with the distribution deviate from the equilibrium in nonequilibrium relaxation. This result can be generalized to any other isothermal macromolecular system using the mathematical theories of large deviations and Markov processes, and at the same time provides the well-known mathematical results with interesting physical interpretations.

  15. Is hypoglycemia fear independently associated with health-related quality of life?

    OpenAIRE

    Shi, Lizheng; Shao, Hui; Zhao, Yingnan; Thomas, Nina A

    2014-01-01

    Objective Patients may fear the symptoms and consequences associated with hypoglycemia. We tested whether fear of hypoglycemia is independently associated with poorer health-related quality of life (HRQOL). Research design and methods Data were collected using direct-mail survey and enrollment information from adult commercial health plan enrollees with type 2 diabetes during a 12-month period (12/01/2008 to 11/30/2009). HRQOL was evaluated by the EuroQol (EQ)–5D index and 12-item Short Form ...

  16. Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits

    Science.gov (United States)

    Kittles, Rick A.; Long, Jeffrey C.; Bergen, Andrew W.; Eggert, Monica; Virkkunen, Matti; Linnoila, Markku; Goldman, David

    1999-01-01

    Association between Y chromosome haplotype variation and alcohol dependence and related personality traits was investigated in a large sample of psychiatrically diagnosed Finnish males. Haplotypes were constructed for 359 individuals using alleles at eight loci (seven microsatellite loci and a nucleotide substitution in the DYZ3 alphoid satellite locus). A cladogram linking the 102 observed haplotype configurations was constructed by using parsimony with a single-step mutation model. Then, a series of contingency tables nested according to the cladogram hierarchy were used to test for association between Y haplotype and alcohol dependence. Finally, using only alcohol-dependent subjects, we tested for association between Y haplotype and personality variables postulated to define subtypes of alcoholism—antisocial personality disorder, novelty seeking, harm avoidance, and reward dependence. Significant association with alcohol dependence was observed at three Y haplotype clades, with significance levels of P = 0.002, P = 0.020, and P = 0.010. Within alcohol-dependent subjects, no relationship was revealed between Y haplotype and antisocial personality disorder, novelty seeking, harm avoidance, or reward dependence. These results demonstrate, by using a fully objective association design, that differences among Y chromosomes contribute to variation in vulnerability to alcohol dependence. However, they do not demonstrate an association between Y haplotype and the personality variables thought to underlie the subtypes of alcoholism. PMID:10097188

  17. Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects.

    Science.gov (United States)

    Sadhasivam, S; Zhang, X; Chidambaran, V; Mavi, J; Pilipenko, V; Mersha, T B; Meller, J; Kaufman, K M; Martin, L J; McAuliffe, J

    2015-10-01

    Opioid effects are potentiated by cannabinoid agonists including anandamide, an endocannabinoid. Inter-individual variability in responses to opioids is a major clinical problem. Multiple deaths and anoxic brain injuries occur every year because of opioid-induced respiratory depression (RD) in surgical patients and drug abusers of opioids and cannabinoids. This study aimed to determine specific associations between genetic variants of fatty acid amide hydrolase (FAAH) and postoperative central opioid adverse effects in children undergoing tonsillectomy. This is a prospective genotype-blinded observational study in which 259 healthy children between 6 and 15 years of age who received standard perioperative care with a standard anesthetic and an intraoperative dose of morphine were enrolled. Associations between frequent polymorphisms of FAAH and central postoperative opioid adverse effects including, RD, postoperative nausea and vomiting (PONV) and prolonged stay in Post Anesthesia Recovery Room (postoperative anesthesia care unit, PACU) due to RD and PONV were analyzed. Five specific FAAH single nucleotide polymorphisms (SNPs) had significant associations with more than twofold increased risk for refractory PONV (adjusted PPACU stay in white children undergoing tonsillectomy. The FAAH SNP, rs324420, is a missense mutation with altered FAAH function and it is linked with other FAAH SNPs associated with PONV and RD in our cohort; association between PONV and rs324420 was confirmed in our extended cohort with additional 66 white children. Specific FAAH polymorphisms are associated with refractory PONV, opioid-related RD, and prolonged PACU stay due to opioid adverse effects in white children undergoing tonsillectomy. PMID:25558980

  18. Age-Related Changes in Children’s Associations of Economic Resources and Race

    Science.gov (United States)

    Elenbaas, Laura; Killen, Melanie

    2016-01-01

    Age-related changes in children’s associations of economic resources and race were investigated. The sample (N = 308) included 5–6 year-olds (n = 153, M = 6.01 years, SD = 0.33 years) and 10–11 year-olds (n = 155, M = 11.12 years, SD = 0.59 years) of African–American (n = 93), European–American (n = 92), Latino (n = 62), Asian–American (n = 23), and multi-racial or multi-ethnic (n = 26) background. Participants matched pairs of target children (African–American and European–American) with visual indicators of low, middle, and high economic status. Children’s associations of economic resources with racial groups changed with age, and reflected different associations at high, middle, and low levels of the economic spectrum. Specifically, children associated targets of both races with middle economic status at a comparable rate, and with age, increasingly associated targets of both races with indicators of middle economic status. By contrast, both younger and older children associated African–American targets with indicators of low economic status more frequently than European–American targets. Finally, children associated African–American targets with indicators of high economic status less frequently with age, resulting in a perceived disparity in favor of European–American targets at high economic status among older children that was not present among younger children. No differences were found by participants’ own racial or ethnic background. These results highlight the need to move beyond a dichotomized view (rich or poor) to include middle economic status when examining children’s associations of economic resources and race. PMID:27378981

  19. Work-related depression and associated factors in a shoe manufacturing factory in Haiphong City, Vietnam

    Directory of Open Access Journals (Sweden)

    Khue Pham Minh

    2014-12-01

    Full Text Available Objectives: To determine the prevalence and associated factors of work-related depression among the employees of a shoe manufacturing factory in Haiphong City, Vietnam. Material and Methods: We carried out this cross-sectional study among 420 workers in 2012 in Le Lai II Shoe Manufacturing Factory in Haiphong City, Vietnam using Karasek’s Job Content Questionnaire (JCQ and the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM IV tool for measuring depression. Results: The study results show that a relatively high proportion of workers (20.7% belongs to the high-strain group based on Karasek’s model. The prevalence of work-related depression among workers was relatively high (18.8%. The factors associated with depression at work were high psychological demand (adjusted OR = 3.0, 95% CI: 1.1–8.3, low social support (adjusted OR = 4.7, 95% CI: 1.2–12.8, inadequate work protection materials (OR = 4.1, 95% CI: 2.2–10.1 and work absenteeism (OR = 6.2, 95% CI: 2.5–18.9. Conclusions: Strengthening the social support network (involving supervisors and co‑workers, reducing psychological job demand and assuring work protection materials at the workplace may highly facilitate reducing work-related depression.

  20. Association between age at first sexual relation and some indicators of sexual behaviour among adolescents.

    Science.gov (United States)

    Yode, Miangotar; LeGrand, Thomas

    2012-06-01

    This study explores the relationship between age at first sexual intercourse and four indicators of sexual behaviour among adolescents aged 14 to 19 years in Burkina Faso, Malawi and Uganda. Analyses are conducted using data from National Surveys of Adolescents, organized in 2004. Multivariate analyses are performed using dichotomous logistic regression and ordered polychotomic logistic regression. Analyses show that initiation of sexual activity before age 14 is more likely to be associated with having a casual sex partner. It is less likely to be associated with condom use at first sexual relation or with systematic condom use in the past 12 months. These associations vary depending on adolescents' country and gender. Delaying onset of sexuality could be a surer and safer way to protect health during adolescence. However, sexual and reproductive health programs that advocate abstinence only are likely to have few positive effects on young people. To better implement this strategy, sexual education for adolescents should be integrated. PMID:22916550

  1. Food-related lifestyles and their association to obesity in five European countries

    DEFF Research Database (Denmark)

    Perez-Cueto, Federico J.A.; Verbeke, Wim; de Barcellos, Marcia Dutra;

    2010-01-01

    categories (20-44 and 45-70 years), and locality of residence (urban, rural). A total of 2437 respondents (51%women, 49% men; mean age 41.4 years, SD 13.1) participated. Obtained data included socio-demographic information, measure of the food-related lifestyle scale and self-reported weights and heights......This paper's objective is toinvestigate the associations between obesity and Food-Related Lifestyles (FRL) in five European countries. A cross-sectional web-based survey was carried out in Belgium, Denmark, Germany, Greece and Poland, January 2008, with quota samples on gender (male, female), age...

  2. Adequate sleep among adolescents is positively associated with health status and health-related behaviors

    Directory of Open Access Journals (Sweden)

    Jeng Yi-Jong

    2006-03-01

    Full Text Available Abstract Background Amount of sleep is an important indicator of health and well-being in children and adolescents. Adequate sleep (AS: adequate sleep is defined as 6–8 hours per night regularly is a critical factor in adolescent health and health-related behaviors. The present study was based on a health promotion project previously conducted on adolescents in Tao-Yuan County, Taiwan. The aim was to examine the relationship between AS during schooldays and excessive body weight, frequency of visiting doctors and health-related behaviors among Taiwanese adolescents. Methods A cross-sectional study design, categorical and multivariate data analyses were used. The hypotheses investigated were: high frequency of AS is positively associated with lack of obesity and less frequent visits to doctors; and high frequency AS is positively associated with health-related behavior. Results A total of 656 boys (53.2% and girls (46.8%, ranging in age from 13–18 years were studied between January and June 2004. Three hundred and fifty seven subjects (54% reported that they slept less than the suggested 6–8 hours on schooldays. A significant negative association was found between low sleep and of the following health-related behaviors: (1 life appreciation; (2 taking responsibility for health; (3 adopting healthy diet; (4 effective stress management; (5 regular exercise; and (6 total AHP score. High frequency AS was associated with low frequencies of obesity after potential confounding factors were controlled. Junior high school adolescents reported significantly higher frequencies of AS than high school participants. Gender, family structure, home location and frequency of television watching or computer use were not significantly associated with AS. Conclusion These findings support the proposition that AS is associated with good health status and high-frequency adoption of health-related behavior. Furthermore, these findings suggest that inadequate

  3. Drug related problems associated with the psychoactive drugs used on geriatric, hospitalized patients

    Directory of Open Access Journals (Sweden)

    Ortega López Irma Leonor

    2012-09-01

    Full Text Available A prospective study was carried out, to identify the drug related problems and to prevent or to solve the negative outcomes associated with medication of the geriatric patients that consumed psychoactive drugs, who were hospitalized. The study was carried out according to the DADER Method of Pharmacotherapy Monitoring, adapted to the Hospital's environment and the theoretical rationale of the Third Consent of Granada was assumed, for the considerations related to the drug related problems and the negative outcomes associated with medication. Thirty five patients were included whose ages ranged between the 60 and 90 years. Thirty six negative associated outcomes were identified, in 34 patients that represented 97.14% incidence. A prevalence of the negative outcomes associated with the necessity was observed, followed by those associated with the security. The inadequate drug uses was the drug related problem that prevailed in the sample. The psychoactive drugs that were related with these results were mainly the anxiolytics, meprobamate and the neuroleptics. Some 82.35% of the interventions were accepted, achieving resolution of 47.06% of the negative outcomes associated with medication.Foi realizada uma pesquisa de intervenção, prospectiva, a fim de identificar problemas relacionados aos medicamentos e evitar ou resolver resultados negativos daí decorrentes, em pacientes idosos que faziam uso de medicamentos psicotrópicos e que foram internados. O estudo foi realizado de acordo com o método DADER para o acompanhamento farmacoterapêutico e assumiram-se os pressupostos teóricos do III Consenso de Granada, as considerações relacionadas com os problemas dos fármacos e os resultados negativos associados à medicação. Foram incluídos 35 pacientes com idades entre 60 e 90 anos. Trinta e seis RM foram identificados em 34 pacientes representando incidência de 97,14% e a prevalência foi observada para os resultados negativos associados com

  4. Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism

    DEFF Research Database (Denmark)

    Madsen, Martin Korsbak; Mc Mahon, Brenda; Andersen, Sofie Bech;

    2016-01-01

    Communication between the amygdala and other brain regions critically regulates sensitivity to threat, which has been associated with risk for mood and affective disorders. The extent to which these neural pathways are genetically determined or correlate with risk-related personality measures is...... S' carriers exhibited a more negative association relative to L(A)L(A) individuals. These findings provide novel evidence for both independent and interactive effects of 5-HTTLPR genotype and neuroticism on amygdala communication, which may mediate effects on risk for mood and affective disorders....... not fully understood. Using functional magnetic resonance imaging, we evaluated independent and interactive effects of the 5-HTTLPR genotype and neuroticism on amygdala functional connectivity during an emotional faces paradigm in 76 healthy individuals. Functional connectivity between left amygdala...

  5. Are severe depressive symptoms associated with infertility-related distress in individuals and their partners?

    DEFF Research Database (Denmark)

    Peterson, Brennan D.; Sejbæk, Camilla Sandal; Prritano, Matthew;

    2014-01-01

    findings: This study adds to the growing body of literature using the couple as the unit of analysis to study the relationship between depression and infertility distress. Recommendations for medical and mental health professionals that underscore the potential risk factors for depressed men and women who......Study question: Are severe depressive symptoms in women and men associated with individual and dyadic infertility-related stress in couples undergoing infertility treatment? Summary answer: Severe depressive symptoms were significantly associated with increased infertility-related distress at both...... the individual and partner level. What is known already?: An infertility diagnosis, the stress of medical treatments and a prior history of depression are risk factors for future depression in those undergoing fertility treatments. Studies examining the impact of severe depressive symptoms on...

  6. Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants

    OpenAIRE

    Alejandro Pelaz; Lorena Gallego; Luis Junquera

    2011-01-01

    Multiple myeloma (MM) is a malignant plasma cell disorder and more than 30% of patients with this pathology develop osteolytic lesions in the jaw. Either pamidronate or zoledronic acid is recommended in patients with MM who have one or more lytic lesions. However, bisphosphonate-related osteonecrosis of the jaws (BRONJ) has been described as a complication associated with their use. Otherwise, the use of endosseous implants in oral rehabilitation is a well-established procedure, with good lon...

  7. Factors associated with recurrence of alcohol-related traffic violations in southern Brazil

    OpenAIRE

    Aurinez R. Schmitz; Goldim, José R; Luciano S. P. Guimarães; Lopes, Fernanda M.; Felix Kessler; Tanara Sousa; Veralice M. Gonçalves; Flavio Pechansky

    2014-01-01

    Objective: To analyze variables associated with recurrence of blood alcohol content (BAC)-related traffic violations among drivers in southern Brazil. Method: This cross-sectional study included 12,204 driving-under-the-influence (DUI) offenders according to data provided by the Rio Grande do Sul state Transportation Department. Sociodemographic characteristics, license duration, license category, and psychological assessment results were analyzed. Drivers convicted of DUI more than once in...

  8. Unraveling mysteries associated with cat-scratch disease, bacillary angiomatosis, and related syndromes.

    OpenAIRE

    Regnery, R; Tappero, J.

    1995-01-01

    The search for the infectious agents responsible for cat-scratch disease, bacillary angiomatosis, and related syndromes has a long and often circuitous history. Recognition of the etiologic agents and a new understanding of the fundamental features of the epidemiology and natural history of modern day Bartonella (formerly Rochalimaea)-associated diseases culminate a multipartite story that combines clinical medicine, traditional microbiology, and novel technological approaches to solve a long...

  9. A database of annotated promoters of genes associated with common respiratory and related diseases

    KAUST Repository

    Chowdhary, Rajesh

    2012-07-01

    Many genes have been implicated in the pathogenesis of common respiratory and related diseases (RRDs), yet the underlying mechanisms are largely unknown. Differential gene expression patterns in diseased and healthy individuals suggest that RRDs affect or are affected by modified transcription regulation programs. It is thus crucial to characterize implicated genes in terms of transcriptional regulation. For this purpose, we conducted a promoter analysis of genes associated with 11 common RRDs including allergic rhinitis, asthma, bronchiectasis, bronchiolitis, bronchitis, chronic obstructive pulmonary disease, cystic fibrosis, emphysema, eczema, psoriasis, and urticaria, many of which are thought to be genetically related. The objective of the present study was to obtain deeper insight into the transcriptional regulation of these disease-associated genes by annotating their promoter regions with transcription factors (TFs) and TF binding sites (TFBSs). We discovered many TFs that are significantly enriched in the target disease groups including associations that have been documented in the literature. We also identified a number of putative TFs/TFBSs that appear to be novel. The results of our analysis are provided in an online database that is freely accessible to researchers at http://www.respiratorygenomics.com. Promoter-associated TFBS information and related genomic features, such as histone modification sites, microsatellites, CpG islands, and SNPs, are graphically summarized in the database. Users can compare and contrast underlying mechanisms of specific RRDs relative to candidate genes, TFs, gene ontology terms, micro-RNAs, and biological pathways for the conduct of metaanalyses. This database represents a novel, useful resource for RRD researchers. Copyright © 2012 by the American Thoracic Society.

  10. Association between religiousness and blood donation among Brazilian postgraduate students from health-related areas

    OpenAIRE

    Edson Zangiacomi Martinez; Rodrigo Guimarães dos Santos Almeida; Ana Carolina Garcia Braz; Antonio Carlos Duarte de Carvalho

    2014-01-01

    OBJECTIVE: The aim of this study was to examine the association between religiousness and blood donation among postgraduate students.METHODS: The Portuguese-language version of the Duke University Religion Index was administered to a sample of 226 Brazilian students with ages ranging from 22 to 55 years. All study participants had completed undergraduate courses in health-related areas.RESULTS: In the present study, 23.5% of the students were regular donors. Organizational religiousness was f...

  11. Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles

    OpenAIRE

    De la Hera, Belén; Urcelay, Elena; Brassat, David; Chan, Andrew; Vidal-Jordana, Angela; Salmen, Anke; Villar, Luisa Maria; Álvarez-Cermeño, José Carlos; Izquierdo, Guillermo; Fernández, Oscar; Oliver, Begoña; Saiz, Albert; Ara, Jose Ramón; Vigo, Ana G.; Arroyo, Rafael

    2014-01-01

    Objectives: We aimed to investigate potential associations between human leukocyte antigen (HLA) class I and class II alleles and the development of anaphylactic/anaphylactoid reactions in patients with multiple sclerosis (MS) treated with natalizumab. Methods: HLA class I and II genotyping was performed in patients with MS who experienced anaphylactic/anaphylactoid reactions and in patients who did not develop infusion-related allergic reactions following natalizumab administration. Results:...

  12. The Associations between Social Support, Health-Related Behaviors, Socioeconomic Status and Depression in Medical Students

    OpenAIRE

    Jeong, Yoolwon; Kim, Jin Young; Ryu, Jae Seon; Lee, Ko Eun; Ha, Eun Hee; Park, Hyesook

    2010-01-01

    OBJECTIVES The objective of this study was to estimate the prevalence of depression in medical students and to evaluate whether interpersonal social support, health-related behaviors, and socio-economic factors were associated with depression in medical students. METHODS The subjects in this study were 120 medical students in Seoul, Korea who were surveyed in September, 2008. The subjects were all women and over the age of 20. Their age, body mass index (BMI), quality of sleep, diet, househol...

  13. Factors associated with time consumption when answering drug-related queries to Scandinavian drug information centres

    DEFF Research Database (Denmark)

    Reppe, L. A.; Spigset, O.; Bottiger, Y.; Christensen, H. R.; Kampmann, J. P.; Damkier, Per; Lydersen, S.; Schjott, J.

    2014-01-01

    Purpose There is little research-based documentation on the services provided by drug information centres (DICs). The aim of this multi-centre study was to explore for the first time the factors associated with time consumption when answering drug-related queries at eight different but comparable...... consumption per query was 178 min (range 4-2540 min). The mean time consumed per query increased by 28 (95 % confidence interval (CI) 23 to 33, p...

  14. A genome-wide association study for age-related hearing impairment in the Saami

    OpenAIRE

    Van Camp, Guy; Van Laer, Lut; Huyghe, Jeroen; Hannula, Samuli; Van Eyken, Els; Stephan, Dietrich; Mäki-Torkko, Elina; Aikio, Pekka; Lysholm-Bernacchi, Alana; Sorri, Martti; Huentelman, Matthew J; Fransen, Erik

    2010-01-01

    International audience This study aimed to contribute to the elucidation of the genetic basis of age-related hearing impairment (ARHI), a common multifactorial disease with an important genetic contribution as demonstrated by heritability studies. We conducted a genome-wide association study (GWAS) in the Finnish Saami, a small ancient genetically isolated population without evidence of demographic expansion. The choice of this study population was motivated by its anticipated higher exten...

  15. A genome-wide association study for age-related hearing impairment in the Saami

    OpenAIRE

    Van Laer, Lut; Huyghe, Jeroen R; Hannula, Samuli; Van Eyken, Els; Stephan, Dietrich A.; Mäki-Torkko, Elina; Aikio, Pekka; Fransen, Erik; Lysholm-Bernacchi, Alana; Sorri, Martti; Huentelman, Matthew J; Van Camp, Guy

    2010-01-01

    This study aimed at contributing to the elucidation of the genetic basis of age-related hearing impairment (ARHI), a common multifactorial disease with an important genetic contribution as demonstrated by heritability studies. We conducted a genome-wide association study (GWAS) in the Finnish Saami, a small, ancient, genetically isolated population without evidence of demographic expansion. The choice of this study population was motivated by its anticipated higher extent of LD, potentially o...

  16. Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits

    OpenAIRE

    Kittles, Rick A.; Long, Jeffrey C.; Bergen, Andrew W; Eggert, Monica; Virkkunen, Matti; Linnoila, Markku; Goldman, David

    1999-01-01

    Association between Y chromosome haplotype variation and alcohol dependence and related personality traits was investigated in a large sample of psychiatrically diagnosed Finnish males. Haplotypes were constructed for 359 individuals using alleles at eight loci (seven microsatellite loci and a nucleotide substitution in the DYZ3 alphoid satellite locus). A cladogram linking the 102 observed haplotype configurations was constructed by using parsimony with a single-step mutation model. Then, a ...

  17. Associations Between Violence Related Behaviors and Self Perceived Health Among Trakya University Students

    OpenAIRE

    Halil Evren; Burcu Tokuç; Galip Ekuklu

    2011-01-01

    Objective: This study was carried out to determine the association between violence related behaviors and self-reported health among university students. Material and Methods: This is a cross-sectional study, which included a representative sample of all students of Trakya University. The sample of 1620 students enrolled at Trakya University was stratified according to sex and actual student number of faculties and colleges and selected by systematic sampling. In addition to descriptive stati...

  18. Associations Between Violence Related Behaviors and Self Perceived Health Among Trakya University Students

    OpenAIRE

    Evren, Halil; Tokuç, Burcu; Ekuklu, Galip

    2011-01-01

    Objective: This study was carried out to determine the association between violence related behaviors and self-reported health among university students. Material and Methods: This is a cross-sectional study, which included a representative sample of all students of Trakya University. The sample of 1620 students enrolled at Trakya University was stratified according to sex and actual student number of faculties and colleges and selected by systematic sampling. In addition to descrip...

  19. Association of diabetes with age-related macular degeneration in the EUREYE study

    OpenAIRE

    Topouzis, F; Anastasopoulos, E.; Augood, C; Bentham, G.C.; Chakravarthy, U; Jong, de, M.C.M.; Rahu, M.; Seland, J.; Soubrane, G.; Tomazzoli, L.; Vingerling, J.R.; Vioque, J.; Young, I. S.; Fletcher, A. E.

    2009-01-01

    Objective: To examine the association between self-reported diabetes history and early or late age-related macular degeneration (AMD) in the European population. Methods: Participants aged 65 years and over in the cross-sectional population-based EUREYE study underwent an eye examination including digital retinal photography. The images were graded at a single centre. A structured questionnaire was administered by trained field workers for putative risk factors for AMD including history of di...

  20. Work-related depression and associated factors in a shoe manufacturing factory in Haiphong City, Vietnam

    OpenAIRE

    Khue Pham Minh

    2014-01-01

    Objectives: To determine the prevalence and associated factors of work-related depression among the employees of a shoe manufacturing factory in Haiphong City, Vietnam. Material and Methods: We carried out this cross-sectional study among 420 workers in 2012 in Le Lai II Shoe Manufacturing Factory in Haiphong City, Vietnam using Karasek’s Job Content Questionnaire (JCQ) and the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM IV) tool for measuring depression. Results: ...

  1. Glucose enhancement of event-related potentials associated with episodic memory and attention

    OpenAIRE

    Brown, Louise; Riby, Leigh

    2013-01-01

    Previous studies have reported that increasing glycaemia by a glucose-containing drink enhances memory functioning. The aim of the present study was to extend this literature by examining the effects of glucose on episodic memory as well as attention processes, and to investigate associated event-related potential (ERP) markers. Fifteen minutes after treatment (25 g glucose or placebo drink), 35 participants performed an old/new recognition memory task and a Stroop colour naming task. Consist...

  2. Association of hair iron levels with creativity and psychological variables related to creativity

    Directory of Open Access Journals (Sweden)

    Hikaru Takeuchi

    2013-12-01

    Full Text Available Creativity generally involves the conception of original and valuable ideas. Previous studies have suggested an association between creativity and the dopaminergic system, and that physical activity facilitates creativity. Iron plays a key role in the dopaminergic system and physical activity. Here, we newly investigated the associations between hair iron levels and creativity, dopamine-related traits and states [novelty seeking, extraversion, and vigor (motivational state], as well as the physical activity level. In the present study, we addressed this issue by performing a hair mineral analysis to determine iron levels and a behavioral creativity test of divergent thinking and related psychological measures among young adults (254 men, 88 women; mean age 20.79 ± 2.03 years. Iron levels did not show any significant association with creativity but displayed significant positive associations with novelty seeking, extraversion, and physical activity level. These results may be partly congruent with the notion that iron plays a key role in the dopaminergic system and imply that iron is important for traits and physical activity, which facilitate creativity. Future interventional or longitudinal studies are warranted to identify any causal effects.

  3. What Do We Know About the Association Between Firearm Legislation and Firearm-Related Injuries?

    Science.gov (United States)

    Santaella-Tenorio, Julian; Cerdá, Magdalena; Villaveces, Andrés; Galea, Sandro

    2016-01-01

    Firearms account for a substantial proportion of external causes of death, injury, and disability across the world. Legislation to regulate firearms has often been passed with the intent of reducing problems related to their use. However, lack of clarity around which interventions are effective remains a major challenge for policy development. Aiming to meet this challenge, we systematically reviewed studies exploring the associations between firearm-related laws and firearm homicides, suicides, and unintentional injuries/deaths. We restricted our search to studies published from 1950 to 2014. Evidence from 130 studies in 10 countries suggests that in certain nations the simultaneous implementation of laws targeting multiple firearms restrictions is associated with reductions in firearm deaths. Laws restricting the purchase of (e.g., background checks) and access to (e.g., safer storage) firearms are also associated with lower rates of intimate partner homicides and firearm unintentional deaths in children, respectively. Limitations of studies include challenges inherent to their ecological design, their execution, and the lack of robustness of findings to model specifications. High quality research on the association between the implementation or repeal of firearm legislation (rather than the evaluation of existing laws) and firearm injuries would lead to a better understanding of what interventions are likely to work given local contexts. This information is key to move this field forward and for the development of effective policies that may counteract the burden that firearm injuries pose on populations. PMID:26905895

  4. Genome-Wide Association of Rice Blast Disease Resistance and Yield-Related Components of Rice.

    Science.gov (United States)

    Wang, Xueyan; Jia, Melissa H; Ghai, Pooja; Lee, Fleet N; Jia, Yulin

    2015-12-01

    Robust disease resistance may require an expenditure of energy that may limit crop yield potential. In the present study, a subset of a United States Department of Agriculture rice core collection consisting of 151 accessions was selected using a major blast resistance (R) gene, Pi-ta, marker and was genotyped with 156 simple sequence repeat (SSR) markers. Disease reactions to Magnaporthe oryzae, the causal agent of rice blast disease, were evaluated under greenhouse and field conditions, and heading date, plant height, paddy and brown seed weight in two field environments were analyzed, using an association mapping approach. A total of 21 SSR markers distributed among rice chromosomes 2 to 12 were associated with blast resistance, and 16 SSR markers were associated with seed weight, heading date, and plant height. Most noticeably, shorter plants were significantly correlated with resistance to blast, rice genomes with Pi-ta were associated with lighter seed weights, and the susceptible alleles of RM171 and RM6544 were associated with heavier seed weight. These findings unraveled a complex relationship between disease resistance and yield-related components. PMID:26284908

  5. Relational Coordination and Organisational Social Capital Association with Characteristics of General Practice

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    Sanne Lykke Lundstrøm

    2014-01-01

    Full Text Available Background. Relational coordination (RC and organisational social capital (OSC are measures of novel aspects of an organisation’s performance, which have not previously been analysed together, in general practice. Objectives. The aim of this study was to analyse the associations between RC and OSC, and characteristics of general practice. Methods. Questionnaire survey study comprising 2074 practices in Denmark. Results. General practitioners (GPs rated both RC and OSC in their general practice higher than their secretaries and nurses. The practice form was statistically significantly associated with high RC and OSC. RC was positively associated with the number of patients listed with a practice per staff, where staff is defined as all members of a practice including both owners and employees. Conclusion. The study showed that RC and OSC were significantly associated with type of profession and practice type. RC was also found to be significantly positively associated with number of patients per staff. However, the low response rate must be taken into consideration when interpreting the self-reported results of this study.

  6. Relational coordination and organisational social capital association with characteristics of general practice.

    Science.gov (United States)

    Lundstrøm, Sanne Lykke; Edwards, Kasper; Knudsen, Thomas Bøllingtoft; Larsen, Pia Veldt; Reventlow, Susanne; Søndergaard, Jens

    2014-01-01

    Background. Relational coordination (RC) and organisational social capital (OSC) are measures of novel aspects of an organisation's performance, which have not previously been analysed together, in general practice. Objectives. The aim of this study was to analyse the associations between RC and OSC, and characteristics of general practice. Methods. Questionnaire survey study comprising 2074 practices in Denmark. Results. General practitioners (GPs) rated both RC and OSC in their general practice higher than their secretaries and nurses. The practice form was statistically significantly associated with high RC and OSC. RC was positively associated with the number of patients listed with a practice per staff, where staff is defined as all members of a practice including both owners and employees. Conclusion. The study showed that RC and OSC were significantly associated with type of profession and practice type. RC was also found to be significantly positively associated with number of patients per staff. However, the low response rate must be taken into consideration when interpreting the self-reported results of this study. PMID:25045537

  7. Using Semantic Association to Extend and Infer Literature-Oriented Relativity Between Terms.

    Science.gov (United States)

    Cheng, Liang; Li, Jie; Hu, Yang; Jiang, Yue; Liu, Yongzhuang; Chu, Yanshuo; Wang, Zhenxing; Wang, Yadong

    2015-01-01

    Relative terms often appear together in the literature. Methods have been presented for weighting relativity of pairwise terms by their co-occurring literature and inferring new relationship. Terms in the literature are also in the directed acyclic graph of ontologies, such as Gene Ontology and Disease Ontology. Therefore, semantic association between terms may help for establishing relativities between terms in literature. However, current methods do not use these associations. In this paper, an adjusted R-scaled score (ARSS) based on information content (ARSSIC) method is introduced to infer new relationship between terms. First, set inclusion relationship between terms of ontology was exploited to extend relationships between these terms and literature. Next, the ARSS method was presented to measure relativity between terms across ontologies according to these extensional relationships. Then, the ARSSIC method using ratios of information shared of term's ancestors was designed to infer new relationship between terms across ontologies. The result of the experiment shows that ARSS identified more pairs of statistically significant terms based on corresponding gene sets than other methods. And the high average area under the receiver operating characteristic curve (0.9293) shows that ARSSIC achieved a high true positive rate and a low false positive rate. Data is available at http://mlg.hit.edu.cn/ARSSIC/. PMID:26684460

  8. Variables associated with peripherally inserted central catheter related infection in high risk newborn infants

    Directory of Open Access Journals (Sweden)

    Uesliz Vianna Rangel

    2014-10-01

    Full Text Available OBJECTIVE: to relate the variables from a surveillance form for intravenous devices in high risk newborn infants with peripherally inserted central catheter related infection.METHODOLOGY: approximately 15 variables were studied, being associated with peripherally inserted central catheter related infection, this being defined by blood culture results. The variables analyzed were obtained from the surveillance forms used with intravenous devices, attached to the medical records of newborn infants weighing between 500 and 1,499 g. The statistical association was defined using the Chi-squared and Student t tests. The study was approved by the Research Ethics Committee of the Instituto Fernandes Figueira under process N. 140.703/12.RESULTS: 63 medical records were analyzed. The infection rate observed was 25.4%. Of the variables analyzed, only three had a statistically-significant relationship with the blood culture - the use of drugs capable of inhibiting acid secretion, post-natal steroid use, and undertaking more than one invasive procedure (p-value of 0.0141, 0.0472 and 0.0277, respectively.CONCLUSION: the absence of significance of the variables of the form may be related to the quality of the records and to the absence of standardization. It is recommended that the teams be encouraged to adhere to the protocol and fill out the form.

  9. Associations Between Violence Related Behaviors and Self Perceived Health Among Trakya University Students

    Directory of Open Access Journals (Sweden)

    Halil Evren

    2011-11-01

    Full Text Available Objective: This study was carried out to determine the association between violence related behaviors and self-reported health among university students. Material and Methods: This is a cross-sectional study, which included a representative sample of all students of Trakya University. The sample of 1620 students enrolled at Trakya University was stratified according to sex and actual student number of faculties and colleges and selected by systematic sampling. In addition to descriptive statistics, Chi Square analysis and Logistic Regression analysis were used for statistical evaluation.Results: 6.3% of the respondents reported that they were exposed to violence, 33.5% of them stated they were involved in a physical fight during the past 12 months, 4.9% of them stated they did not go to school at least one day during the past 30 days because they felt unsafe and 4.4% of the students reported they had attempted suicide during the past 12 months. The analyses have shown that violence related behaviors were significantly associated with poor health after controlling the potential confounders. Conclusion: There is a need for more prospective studies for exploring the effects of violence related behaviors to health. Interventions targeting youths who engage in violence should consider that violence related behaviors may be markers for poor health.

  10. Whole Genome Association Studies of Residual Feed Intake and Related Traits in the Pig.

    Directory of Open Access Journals (Sweden)

    Suneel K Onteru

    Full Text Available Residual feed intake (RFI, a measure of feed efficiency, is the difference between observed feed intake and the expected feed requirement predicted from growth and maintenance. Pigs with low RFI have reduced feed costs without compromising their growth. Identification of genes or genetic markers associated with RFI will be useful for marker-assisted selection at an early age of animals with improved feed efficiency.Whole genome association studies (WGAS for RFI, average daily feed intake (ADFI, average daily gain (ADG, back fat (BF and loin muscle area (LMA were performed on 1,400 pigs from the divergently selected ISU-RFI lines, using the Illumina PorcineSNP60 BeadChip. Various statistical methods were applied to find SNPs and genomic regions associated with the traits, including a Bayesian approach using GenSel software, and frequentist approaches such as allele frequency differences between lines, single SNP and haplotype analyses using PLINK software. Single SNP and haplotype analyses showed no significant associations (except for LMA after genomic control and FDR. Bayesian analyses found at least 2 associations for each trait at a false positive probability of 0.5. At generation 8, the RFI selection lines mainly differed in allele frequencies for SNPs near (<0.05 Mb genes that regulate insulin release and leptin functions. The Bayesian approach identified associations of genomic regions containing insulin release genes (e.g., GLP1R, CDKAL, SGMS1 with RFI and ADFI, of regions with energy homeostasis (e.g., MC4R, PGM1, GPR81 and muscle growth related genes (e.g., TGFB1 with ADG, and of fat metabolism genes (e.g., ACOXL, AEBP1 with BF. Specifically, a very highly significantly associated QTL for LMA on SSC7 with skeletal myogenesis genes (e.g., KLHL31 was identified for subsequent fine mapping.Important genomic regions associated with RFI related traits were identified for future validation studies prior to their incorporation in marker

  11. A genomic background based method for association analysis in related individuals.

    Directory of Open Access Journals (Sweden)

    Najaf Amin

    Full Text Available BACKGROUND: Feasibility of genotyping of hundreds and thousands of single nucleotide polymorphisms (SNPs in thousands of study subjects have triggered the need for fast, powerful, and reliable methods for genome-wide association analysis. Here we consider a situation when study participants are genetically related (e.g. due to systematic sampling of families or because a study was performed in a genetically isolated population. Of the available methods that account for relatedness, the Measured Genotype (MG approach is considered the 'gold standard'. However, MG is not efficient with respect to time taken for the analysis of genome-wide data. In this context we proposed a fast two-step method called Genome-wide Association using Mixed Model and Regression (GRAMMAR for the analysis of pedigree-based quantitative traits. This method certainly overcomes the drawback of time limitation of the measured genotype (MG approach, but pays in power. One of the major drawbacks of both MG and GRAMMAR, is that they crucially depend on the availability of complete and correct pedigree data, which is rarely available. METHODOLOGY: In this study we first explore type 1 error and relative power of MG, GRAMMAR, and Genomic Control (GC approaches for genetic association analysis. Secondly, we propose an extension to GRAMMAR i.e. GRAMMAR-GC. Finally, we propose application of GRAMMAR-GC using the kinship matrix estimated through genomic marker data, instead of (possibly missing and/or incorrect genealogy. CONCLUSION: Through simulations we show that MG approach maintains high power across a range of heritabilities and possible pedigree structures, and always outperforms other contemporary methods. We also show that the power of our proposed GRAMMAR-GC approaches to that of the 'gold standard' MG for all models and pedigrees studied. We show that this method is both feasible and powerful and has correct type 1 error in the context of genome-wide association analysis

  12. Conservation in Mammals of Genes Associated with Aggression-Related Behavioral Phenotypes in Honey Bees.

    Directory of Open Access Journals (Sweden)

    Hui Liu

    2016-06-01

    Full Text Available The emerging field of sociogenomics explores the relations between social behavior and genome structure and function. An important question is the extent to which associations between social behavior and gene expression are conserved among the Metazoa. Prior experimental work in an invertebrate model of social behavior, the honey bee, revealed distinct brain gene expression patterns in African and European honey bees, and within European honey bees with different behavioral phenotypes. The present work is a computational study of these previous findings in which we analyze, by orthology determination, the extent to which genes that are socially regulated in honey bees are conserved across the Metazoa. We found that the differentially expressed gene sets associated with alarm pheromone response, the difference between old and young bees, and the colony influence on soldier bees, are enriched in widely conserved genes, indicating that these differences have genomic bases shared with many other metazoans. By contrast, the sets of differentially expressed genes associated with the differences between African and European forager and guard bees are depleted in widely conserved genes, indicating that the genomic basis for this social behavior is relatively specific to honey bees. For the alarm pheromone response gene set, we found a particularly high degree of conservation with mammals, even though the alarm pheromone itself is bee-specific. Gene Ontology identification of human orthologs to the strongly conserved honey bee genes associated with the alarm pheromone response shows overrepresentation of protein metabolism, regulation of protein complex formation, and protein folding, perhaps associated with remodeling of critical neural circuits in response to alarm pheromone. We hypothesize that such remodeling may be an adaptation of social animals to process and respond appropriately to the complex patterns of conspecific communication essential for

  13. Conservation in Mammals of Genes Associated with Aggression-Related Behavioral Phenotypes in Honey Bees

    Science.gov (United States)

    Robinson, Gene E.; Jakobsson, Eric

    2016-01-01

    The emerging field of sociogenomics explores the relations between social behavior and genome structure and function. An important question is the extent to which associations between social behavior and gene expression are conserved among the Metazoa. Prior experimental work in an invertebrate model of social behavior, the honey bee, revealed distinct brain gene expression patterns in African and European honey bees, and within European honey bees with different behavioral phenotypes. The present work is a computational study of these previous findings in which we analyze, by orthology determination, the extent to which genes that are socially regulated in honey bees are conserved across the Metazoa. We found that the differentially expressed gene sets associated with alarm pheromone response, the difference between old and young bees, and the colony influence on soldier bees, are enriched in widely conserved genes, indicating that these differences have genomic bases shared with many other metazoans. By contrast, the sets of differentially expressed genes associated with the differences between African and European forager and guard bees are depleted in widely conserved genes, indicating that the genomic basis for this social behavior is relatively specific to honey bees. For the alarm pheromone response gene set, we found a particularly high degree of conservation with mammals, even though the alarm pheromone itself is bee-specific. Gene Ontology identification of human orthologs to the strongly conserved honey bee genes associated with the alarm pheromone response shows overrepresentation of protein metabolism, regulation of protein complex formation, and protein folding, perhaps associated with remodeling of critical neural circuits in response to alarm pheromone. We hypothesize that such remodeling may be an adaptation of social animals to process and respond appropriately to the complex patterns of conspecific communication essential for social organization

  14. Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma.

    Science.gov (United States)

    Mendez, Joe S; Govindan, Ashwin; Leong, Jacqueline; Gao, Feng; Huang, Jiayi; Campian, Jian L

    2016-04-01

    Management of patients with glioblastoma (GBM) often includes radiation (RT) and temozolomide (TMZ). The association between severe treatment-related lymphopenia (TRL) after the standard chemoradiation and reduced survival has been reported in GBM patients with the median age of 57. Similar findings were described in patients with head and neck, non-small cell lung, and pancreatic cancers. This retrospective study is designed to evaluate whether elderly GBM patients (age ≥65) develop similar TRL after RT/TMZ and whether such TRL is associated with decreased survival. Serial total lymphocyte counts (TLC) were retrospectively reviewed in patients (age ≥65) with newly diagnosed GBM undergoing RT/TMZ and associated with treatment outcomes. Seventy-two patients were eligible: median KPS 70, median age 71 years (range 65-86) with 56 % of patients >70 years, 53 % female, 31 % received RT ≤45 Gy. Baseline median TLC was 1100 cells/mm(3) which fell by 41 % to 650 cells/mm(3) 2 months after initiating RT/TMZ (p TLC <500 cells/mm(3) at 2 months had a shorter survival than those with higher TLCs with a median overall survival of 4.6 versus 11.6 months, respectively. Multivariate analysis revealed a significant association between TRL and survival (HR 2.76, 95 % CI 1.30-5.86, p = 0.008). Treatment-related lymphopenia is frequent, severe, and an independent predictor for survival in elderly patients with GBM. These findings add to the body of evidence that immunosuppression induced by chemoradiation is associated with inferior clinical outcomes. Prospective studies are needed to confirm these findings suggesting that immune preservation is important in this cancer. PMID:26725885

  15. Conservation in Mammals of Genes Associated with Aggression-Related Behavioral Phenotypes in Honey Bees.

    Science.gov (United States)

    Liu, Hui; Robinson, Gene E; Jakobsson, Eric

    2016-06-01

    The emerging field of sociogenomics explores the relations between social behavior and genome structure and function. An important question is the extent to which associations between social behavior and gene expression are conserved among the Metazoa. Prior experimental work in an invertebrate model of social behavior, the honey bee, revealed distinct brain gene expression patterns in African and European honey bees, and within European honey bees with different behavioral phenotypes. The present work is a computational study of these previous findings in which we analyze, by orthology determination, the extent to which genes that are socially regulated in honey bees are conserved across the Metazoa. We found that the differentially expressed gene sets associated with alarm pheromone response, the difference between old and young bees, and the colony influence on soldier bees, are enriched in widely conserved genes, indicating that these differences have genomic bases shared with many other metazoans. By contrast, the sets of differentially expressed genes associated with the differences between African and European forager and guard bees are depleted in widely conserved genes, indicating that the genomic basis for this social behavior is relatively specific to honey bees. For the alarm pheromone response gene set, we found a particularly high degree of conservation with mammals, even though the alarm pheromone itself is bee-specific. Gene Ontology identification of human orthologs to the strongly conserved honey bee genes associated with the alarm pheromone response shows overrepresentation of protein metabolism, regulation of protein complex formation, and protein folding, perhaps associated with remodeling of critical neural circuits in response to alarm pheromone. We hypothesize that such remodeling may be an adaptation of social animals to process and respond appropriately to the complex patterns of conspecific communication essential for social organization

  16. Gagging and Associations with Dental Care-Related Fear, Fear of Pain, and Beliefs about Treatment

    Science.gov (United States)

    Randall, Cameron L.; Shulman, Grant P.; Crout, Richard J.; McNeil, Daniel W.

    2014-01-01

    Background Gagging is a behavioral response that interferes with oral health care and has been suggested to relate to dental care-related fear. Little is known, however, about the epidemiology of gagging during dental treatment. Methods To explore this phenomenon, 478 participants were recruited from the waiting area of an oral diagnosis clinic. Participants completed the Dental Fear Survey, the Short Form-Fear of Pain Questionnaire, Dental Beliefs Scale, and a demographics questionnaire that included items about problems with gagging. Results Over half of the participants reported gagging on at least one occasion during dental visits, with 7.5% almost always, or always gagging. With higher frequency of problems with gagging, patients were more likely to have greater levels of dental care-related fear, fear of pain, and more negative beliefs of dental professionals and dental treatment. Further, participants who gagged more readily had greater dental care-related fear than other gaggers. Conclusion Gagging in the dental clinic is a prevalent problem, and dental care-related fear and fear of pain are associated with more frequent gagging. Clinical Implications Given the prevalence of patients reporting problem gagging, it may be helpful for providers to assess for this barrier to treatment. By targeting dental care-related fear, fear of pain, and negative beliefs about dental care in patients who often gag in the clinic, gagging may be reduced in frequency or intensity, potentially making treatment more comfortable for patients and easier for dental care providers. PMID:24789238

  17. The Association between Vitamin D and Health-Related Quality of Life in Korean Adults

    Science.gov (United States)

    Kim, Ji Sun; Baek, Jin Kyung; Cho, Ho Jin; Kim, Ye Seul

    2016-01-01

    Background We examined the relationship between vitamin D status and health-related quality of life, and explored other related factors in the general Korean population. Methods We used data from the 2007–2012 Korea National Health and Nutrition Examination Survey on 14,104 adults, aged 20–49 years, who had consented to serum vitamin D measurement and answered health-related quality of life questions. EuroQol-5 was used for measurement. Serum vitamin D levels were measured at intervals of 0–9.99, 10–19.99, 20–29.99, and ≥30 ng/mL. Results Participants with higher serum vitamin D (serum 25-hydroxyvitamin D) levels were significantly less likely to report problems with depression and anxiety. After adjustment for age, gender, income level, education level, marital status, alcohol consumption, smoking status, and the existence of depressive disorders, the odds ratio for reporting a problem with depression and anxiety was 0.60 (95% confidence interval [CI], 0.39–0.91). The odds ratio for the prevalence of any problem was 0.69 (95% CI, 0.53–0.89) before adjustment, but was not statistically significant after adjustment. No significant associations were observed for problems with mobility, self-care, usual activity, or pain and discomfort. Conclusion This is the first study to examine the associations between vitamin D and health-related quality of life for the general Korean population. Vitamin D status was not significantly associated with the dimensions of EuroQol-5 except for depression and anxiety problems. PMID:27468340

  18. Relational victimization, loneliness and depressive symptoms: indirect associations via self and peer reports of rejection sensitivity.

    Science.gov (United States)

    Zimmer-Gembeck, Melanie J; Trevaskis, Sarah; Nesdale, Drew; Downey, Geraldine A

    2014-04-01

    Theory suggests that aversive social experiences generate emotional maladjustment because they prompt the development of a hypersensitivity to perceiving and overreacting to rejection. The primary aim of this study was to test hypothesized direct and indirect (via rejection sensitivity) links of overt/relational victimization and friendship conflict with early adolescents' loneliness and depressive symptoms. Participants were 366 Australian early adolescents age 10-14 years (50.5 % girls). Using both a self-report and peer-report measure of rejection sensitivity, no difference was found when comparing the significant correlations of each measure with loneliness and depressive symptoms. Tests of direct and indirect associations with structural equation modeling showed that adolescents higher in relational victimization reported more loneliness and depressive symptoms and part of this association was by way of their greater self-reports of rejection sensitivity and their peers' identification that they were higher in rejection sensitivity. Additionally, relational victimization was the only unique correlate of emotional maladjustment, and adolescents who reported more overt victimization were identified by their peers as higher in rejection sensitivity. Finally, gender and rejection sensitivity were tested as moderators. No gender moderation was found, but friendship conflict was associated more strongly with emotional maladjustment for adolescents low, rather than high, in rejection sensitivity. These findings identify relational victimization as particularly salient for emotional maladjustment both directly and indirectly via links with elevated rejection sensitivity. They show how rejection sensitivity and aversive experiences may contribute independently and jointly to emotional maladjustment for both boys and girls. PMID:23955324

  19. School-related risk and protective factors associated with truancy among urban youth placed at risk.

    Science.gov (United States)

    Henry, Kimberly L; Huizinga, David H

    2007-11-01

    Truancy is a serious concern in the United States. Its negative effects are so pervasive that in 2003 the Office of Juvenile Justice and Delinquency Prevention named truancy prevention a national priority. Effective prevention of truancy requires a thorough understanding of the characteristics that describe truant youth as well as factors that may put them at risk for truancy. Unfortunately, surprisingly little is known about the correlates and/or causes of truancy. In this paper we explore associations between truancy and several salient school-related risk and protective factors among a sample of youth who grew up in socially disorganized neighborhoods of Denver, CO. We demonstrate that several school-related risk and protective factors are associated with truancy. Perhaps most importantly, we identify that the two most robust predictors are school performance and involvement with delinquent peers, and that these two variables form a synergistic relationship in which the relationship between delinquent peer association and truancy is mitigated among students who perform well in school. EDITORS' STRATEGIC IMPLICATIONS: The authors use data from a large probability sample drawn from neighborhoods with high crime rates to identify key correlates of truancy. They also draw attention to the dearth of efficacious truancy prevention efforts in spite of the magnitude of the problem. PMID:18004658

  20. Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status.

    Directory of Open Access Journals (Sweden)

    Emmanuelle Bouzigon

    Full Text Available BACKGROUND: The nitric oxide (NO pathway is involved in asthma, and eosinophils participate in the regulation of the NO pool in pulmonary tissues. We investigated associations between single nucleotide polymorphisms (SNPs of NO synthase genes (NOS and biological NO-related phenotypes measured in two compartments (exhaled breath condensate and plasma and blood eosinophil counts. METHODOLOGY: SNPs (N = 121 belonging to NOS1, NOS2 and NOS3 genes were genotyped in 1277 adults from the French Epidemiological study on the Genetics and Environment of Asthma (EGEA. Association analyses were conducted on four quantitative phenotypes: the exhaled fraction of NO (Fe(NO, plasma and exhaled breath condensate (EBC nitrite-nitrate levels (NO2-NO3 and blood eosinophils in asthmatics and non-asthmatics separately. Genetic heterogeneity of these phenotypes between asthmatics and non-asthmatics was also investigated. PRINCIPAL FINDINGS: In non-asthmatics, after correction for multiple comparisons, we found significant associations of Fe(NO levels with three SNPs in NOS3 and NOS2 (P ≤ 0.002, and of EBC NO2-NO3 level with NOS2 (P = 0.002. In asthmatics, a single significant association was detected between Fe(NO levels and one SNP in NOS3 (P = 0.004. Moreover, there was significant heterogeneity of NOS3 SNP effect on Fe(NO between asthmatics and non-asthmatics (P = 0.0002 to 0.005. No significant association was found between any SNP and NO2-NO3 plasma levels or blood eosinophil counts. CONCLUSIONS: Variants in NO synthase genes influence Fe(NO and EBC NO2-NO3 levels in adults. These genetic determinants differ according to asthma status. Significant associations were only detected for exhaled phenotypes, highlighting the critical relevance to have access to specific phenotypes measured in relevant biological fluid.

  1. A Clinico-Epidemiologic Study of Neurologic Associations and Factors Related to Speech and Language Delay

    Directory of Open Access Journals (Sweden)

    Parakh Manish, Parakh Poonam, Bhansali Suman , Gurjar Anoop Singh, Parakh Priyanka, Mathur Gagan

    2012-09-01

    Full Text Available Objectives: SLD is a significant neurodevelopmental complication and association of several neurologic disorders. The current study evaluates the neurologic associations and factors related to SLD. Methods: A one year retrospective study was done at Tertiary Care Center in India. Medical records of patients examined at Pediatric Neurology Clinic for SLD, between December 2009 and December 2010 were studied and the collected data was analyzed. Results: The prevalence of SLD was 16.27% and the Male : Female ratio was 2.76:1 in this study. GDD, Seizure disorder and ADHD were major comorbid conditions. Significant associations seen were; PIH, IUGR, Oligohyraminos, Perinatal- Neonatal resuscitation, LBW, LSCS, neonatal Icterus and seizures. There was a positive family history of SLD in 23.85% patients. EEG was epileptiform in 45.87% patients and features suggestive of Perinatal ABI due to varied etiology was the major neuroradiologic finding followed by congenital structural abnormalities. No specific diagnosis was possible in 33.94% patients, but 17.43% had Primary Epilepsy syndrome and 17.43% had a suspected Neurogenetic etiology. Conclusion: Exact etiological diagnosis of SLD is challenging & not possible on many occasions. Most important associations include seizure disorder, ADHD, autism, neonatal resuscitation and Epileptiform EEG with or without clinical seizure activity. Most of these patients have either an epilepsy syndrome or suspected Neurometabolic or Neurogenetic etiology.

  2. Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration.

    Directory of Open Access Journals (Sweden)

    Jeffrey A Canter

    Full Text Available The objective of this study was to determine if MTND2*LHON4917G (4917G, a specific non-synonymous polymorphism in the mitochondrial genome previously associated with neurodegenerative phenotypes, is associated with increased risk for age-related macular degeneration (AMD. A preliminary study of 393 individuals (293 cases and 100 controls ascertained at Vanderbilt revealed an increased occurrence of 4917G in cases compared to controls (15.4% vs.9.0%, p = 0.11. Since there was a significant age difference between cases and controls in this initial analysis, we extended the study by selecting Caucasian pairs matched at the exact age at examination. From the 1547 individuals in the Vanderbilt/Duke AMD population association study (including 157 in the preliminary study, we were able to match 560 (280 cases and 280 unaffected on exact age at examination. This study population was genotyped for 4917G plus specific AMD-associated nuclear genome polymorphisms in CFH, LOC387715 and ApoE. Following adjustment for the listed nuclear genome polymorphisms, 4917G independently predicts the presence of AMD (OR = 2.16, 95%CI 1.20-3.91, p = 0.01. In conclusion, a specific mitochondrial polymorphism previously implicated in other neurodegenerative phenotypes (4917G appears to convey risk for AMD independent of recently discovered nuclear DNA polymorphisms.

  3. Mercury in Hair Is Inversely Related to Disease Associated Damage in Systemic Lupus Erythematosus

    Science.gov (United States)

    Crowe, William; Doherty, Leanne; Watson, Gene; Armstrong, David; Ball, Elisabeth; Magee, Pamela; Allsopp, Philip; Bell, Aubrey; Strain, J. J.; McSorley, Emeir

    2015-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, and environmental factors are proposed to exacerbate existing symptoms. One such environmental factor is mercury. The aim of this study was to investigate the relationship between exposure to mercury (Hg) and disease activity and disease associated damage in Total Hg concentrations in hair and urine were measured in 52 SLE patients. Dental amalgams were quantified. Disease activity was assessed using three indexes including the British Isles Lupus Assessment Group Index (BILAG). Disease associated damage was measured using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology SLICC/ACR Damage Index. Pearson’s correlation identified a significant negative correlation between hair Hg and BILAG (r = −0.323, p = 0.029) and SLICC/ACR (r = −0.377, p = 0.038). Multiple regression analysis identified hair Hg as a significant predictor of disease associated damage as determined by SLICC/ACR (β = −0.366, 95% confidence interval (CI): −1.769, −0.155 p = 0.019). Urinary Hg was not related to disease activity or damage. Fish consumption is the primary route of MeHg exposure in humans and the inverse association of hair Hg with disease activity observed here might be explained by the anti-inflammatory effects of n-3 long chain polyunsaturated fatty acids also found in fish. PMID:26703710

  4. Associations between neck musculoskeletal complaints and work related factors among public service computer workers in Kaunas

    Directory of Open Access Journals (Sweden)

    Gintaré Kaliniene

    2013-10-01

    Full Text Available Objectives:Information technologies have been developing very rapidly, also in the case of occupational activities. Epidemiological studies have shown that employees, who work with computers, are more likely to complain of musculoskeletal disorders (MSD. The aim of this study was to evaluate associations between neck MSD and individual and work related factors. Materials and Methods: The investigation which consisted of two parts - a questionnaire study (using Nordic Musculoskeletal questionnaire and Copenhagen Psychosocial Questionnaire and a direct observation (to evaluate ergonomic work environment using RULA method was carried out in three randomly selected public sector companies of Kaunas. The study population consisted of 513 public service office workers. Results: The survey showed that neck MSDs were very common in the investigated population. The prevalence rate amounted to 65.7%. According to our survey neck MSDs were significantly associated with older age, bigger work experience, high quantitative and cognitive job demands, working for longer than 2 h without taking a break as well as with higher ergonomic risk score. The fully adjusted model working for longer than 2 h without taking a break had the strongest associations with neck complaints. Conclusion: It was confirmed, that neck MSDs were significantly associated with individual factors as well as conditions of work, therefore, preventive acions against neck complaints should be oriented at psychosocial and ergonomic work environment as well as at individual factors.

  5. Mercury in Hair Is Inversely Related to Disease Associated Damage in Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    William Crowe

    2015-12-01

    Full Text Available Systemic lupus erythematosus (SLE is an autoimmune inflammatory disease, and environmental factors are proposed to exacerbate existing symptoms. One such environmental factor is mercury. The aim of this study was to investigate the relationship between exposure to mercury (Hg and disease activity and disease associated damage in Total Hg concentrations in hair and urine were measured in 52 SLE patients. Dental amalgams were quantified. Disease activity was assessed using three indexes including the British Isles Lupus Assessment Group Index (BILAG. Disease associated damage was measured using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology SLICC/ACR Damage Index. Pearson’s correlation identified a significant negative correlation between hair Hg and BILAG (r = −0.323, p = 0.029 and SLICC/ACR (r = −0.377, p = 0.038. Multiple regression analysis identified hair Hg as a significant predictor of disease associated damage as determined by SLICC/ACR (β = −0.366, 95% confidence interval (CI: −1.769, −0.155 p = 0.019. Urinary Hg was not related to disease activity or damage. Fish consumption is the primary route of MeHg exposure in humans and the inverse association of hair Hg with disease activity observed here might be explained by the anti-inflammatory effects of n-3 long chain polyunsaturated fatty acids also found in fish.

  6. Association of obstructive sleep apnea severity with exercise capacity and health-related quality of life

    Directory of Open Access Journals (Sweden)

    Katrina L Butner

    2013-01-01

    Full Text Available Background: Current research is inconclusive as to whether obstructive sleep apnea severity directly limits exercise capacity and lowers health-related quality of life (HRQoL. Aims: The aim of this study was to evaluate the association of obstructive sleep apnea severity with determinants of exercise capacity and HRQoL. Subjects and Methods: Subjects were evaluated by home somnography and classified as no obstructive sleep apnea ( n = 43 or as having mild ( n = 27, moderate or severe obstructive sleep apnea ( n = 21. Exercise capacity was assessed by a ramping cycle ergometer test, and HRQoL was assessed with the SF-36 questionnaire. Results: Greater obstructive sleep apnea severity was associated with older age, higher body weight, higher body mass index, lower peak aerobic capacity, a higher percentage of peak aerobic capacity at a submaximal exercise intensity of 55 watts, and lower physical component summary score from the SF-36. None of these variables were statistically different among obstructive sleep apnea severity groups after controlling for age and body weight. Obstructive sleep apnea severity was not associated with any cardiorespiratory fitness or HRQoL parameter. Conclusions: Obstructive sleep apnea severity has no independent association with exercise capacity or HRQoL.

  7. Migration-related phenotypic divergence is associated with epigenetic modifications in rainbow trout.

    Science.gov (United States)

    Baerwald, Melinda R; Meek, Mariah H; Stephens, Molly R; Nagarajan, Raman P; Goodbla, Alisha M; Tomalty, Katharine M H; Thorgaard, Gary H; May, Bernie; Nichols, Krista M

    2016-04-01

    Migration is essential for the reproduction and survival of many animals, yet little is understood about its underlying molecular mechanisms. We used the salmonid Oncorhynchus mykiss to gain mechanistic insight into smoltification, which is a morphological, physiological and behavioural transition undertaken by juveniles in preparation for seaward migration. O. mykiss is experimentally tractable and displays intra- and interpopulation variation in migration propensity. Migratory individuals can produce nonmigratory progeny and vice versa, indicating a high degree of phenotypic plasticity. One potential way that phenotypic plasticity might be linked to variation in migration-related life history tactics is through epigenetic regulation of gene expression. To explore this, we quantitatively measured genome-scale DNA methylation in fin tissue using reduced representation bisulphite sequencing of F2 siblings produced from a cross between steelhead (migratory) and rainbow trout (nonmigratory) lines. We identified 57 differentially methylated regions (DMRs) between smolt and resident O. mykiss juveniles. DMRs were high in magnitude, with up to 62% differential methylation between life history types, and over half of the gene-associated DMRs were in transcriptional regulatory regions. Many of the DMRs encode proteins with activity relevant to migration-related transitions (e.g. circadian rhythm pathway, nervous system development, protein kinase activity). This study provides the first evidence of a relationship between epigenetic variation and life history divergence associated with migration-related traits in any species. PMID:25958780

  8. Previous PICC Placement May Be Associated With Catheter-Related Infections in Hemodialysis Patients

    International Nuclear Information System (INIS)

    Background: Catheter-related infections (CRIs) are a significant source of morbidity and mortality in hemodialysis patients. The identification of novel, modifiable risk factors for CRIs may lead to improved outcomes in this population. Peripherally inserted central catheters (PICCs) have been hypothesized to compromise vascular access due to vascular damage and venous thrombosis, whereas venous thrombosis has been linked to the development of CRIs. Here we examine the association between PICC placement and CRIs. Methods: A retrospective review was performed of all chronic hemodialysis catheter placements and exchanges performed at a large university hospital from September 2003 to September 2008. History of PICC line use was determined by examining hospital radiologic records from December 1993 to September 2008. Catheter-related complications were assessed and correlated with PICC line history. Results: One hundred eighty-five patients with 713 chronic tunneled hemodialysis catheter placements were identified. Thirty-eight of those patients (20.5%) had a history of PICC placement; these patients were more likely to have CRIs (odds ratio = 2.46, 95% confidence interval = 1.71–3.53, p < .001) compared with patients without a history of PICC placement. There was no difference between the two groups in age or number of catheters placed. Conclusion: Previous PICC placement may be associated with catheter-related infections in hemodialysis patients.

  9. Exression and Cloning of Apoptosis-related Gene and Its Association with Hepatocellular Carcinoma in Qidong

    Institute of Scientific and Technical Information of China (English)

    LUDongdong; ZHANGXiran; 等

    2002-01-01

    Objective:To explore the molecular basis of hepatocarcinogenesis by cloning and expressing a novel liver cancer apoptosis -related gene.Methods:With homologous screening and RT-PCR,we had cloned an apoptosis-related gene APG from liver cancer cells,compared its expression in hepatocellular carcinoma(HCC) tissue and paracarcinoma tissue,and analyzed its sequence from these tissues.The association of APG gene expression with HCC was investigated.Results:A new gene APG was cloned with a full-legth cDNA of 563 bp.Sequencing analysis showed heterogeneity of APG gene from hepatocarcinoma tissue and from paracarcinoma tissue.Among 50 cases of liver cancer,APG gene expressions were down-regulated in 42 cases(84%) ,while up-regulated in 8 cases(16%,P0.05).Conclusion APG is an appoptosis-relate gene and down-regualted in HCC.Its expression is associated with many clinical and pathologic features of HCC,suggesting that APG gene is probably involved in the tumorigenesis of HCC.

  10. What are sleep-related experiences? Associations with transliminality, psychological distress, and life stress.

    Science.gov (United States)

    Soffer-Dudek, Nirit; Shahar, Golan

    2009-12-01

    Sleep-related experiences [Watson, D. (2001). Dissociations of the night: Individual differences in sleep-related experiences and their relation to dissociation and schizotypy. Journal of Abnormal Psychology, 110, 526-535] refer to a host of nocturnal altered-consciousness phenomena, including narcoleptic tendencies, nightmares, problem-solving dreams, waking dreams, and lucid dreams. In an attempt to clarify the meaning of this construct, we examined cross-sectional and longitudinal associations of sleep-related experiences (SREs), altered-consciousness tendencies (i.e., dissociation and transliminality), psychological distress, childhood maltreatment (i.e., abuse and neglect), and life stress in young adults. Both types of SREs (general SREs and lucid dreaming) were found to be distinguishable from altered-consciousness tendencies. Transliminality emerged as a longitudinal predictor of both general SREs and lucid dreams. Psychological distress and an increase in life stress predicted an increase in general SREs over a 3-month interval. We conclude that transliminality is a general altered-consciousness trait that accounts for some of the individual differences in sleep-related experiences, and that general sleep experiences are an outcome of psychological distress and life stress. PMID:18799323

  11. Length of stay and associated costs of obesity related hospital admissions in Ireland.

    LENUS (Irish Health Repository)

    Vellinga, Akke

    2008-01-01

    BACKGROUND: Obesity is the cause of other chronic diseases, psychological problems, obesity shortens the lifespan and puts strain on health systems. The risk associated with childhood obesity in particular, which will accelerate the development of adult morbidity and mortality, has been identified as an emerging public health problem. METHODS: To estimate the length of stay and associated hospital costs for obesity related illnesses a cost of illness study was set up. All discharges from all acute hospitals in the Republic of Ireland from 1997 to 2004 with a principal or secondary diagnostic code for obesity for all children from 6 to 18 years of age and for adults were collected.A discharge frequency was calculated by dividing obesity related discharges by the total number of diagnoses (principal and secondary) for each year. The hospital costs related to obesity was calculated based on the total number of days care. RESULTS: The discharge frequency of obesity related conditions increased from 1.14 in 1997 to 1.49 in 2004 for adults and from 0.81 to 1.37 for children. The relative length of stay (number of days in care for obesity related conditions per 1000 days of hospital care given) increased from 1.47 in 1997 to 4.16 in 2004 for children and from 3.68 in 1997 to 6.74 in 2004 for adults.Based on the 2001 figures for cost per inpatient bed day, the annual hospital cost was calculated to be 4.4 Euromillion in 1997, increasing to 13.3 Euromillion in 2004. At a 20% variable hospital cost the cost ranges from 0.9 Euromillion in 1997 to 2.7 Euromillion in 2004; a 200% increase. CONCLUSION: The annual increase in the proportion of hospital discharges related to obesity is alarming. This increase is related to a significant increase in economic costs. This paper emphasises the need for action at an early stage of life. Health promotion and primary prevention of obesity should be high on the political agenda.

  12. Lower heart rate variability is associated with cancer-related fatigue in breast cancer survivors

    Directory of Open Access Journals (Sweden)

    Alexandra Dupont

    2012-09-01

    Full Text Available Background : Fatigue is the most common and distressing symptom reported by breast cancer survivors and yet the pathophysiology of cancer-related fatigue remains largely unknown. Fatigue is associated with lower parasympathetic and higher sympathetic nervous system activity in non-cancer samples, but only one study has demonstrated this same relationship in breast cancer survivors. This study evaluates the relationship between fatigue and basal autonomic nervous system activity as measured by heart rate variability (HRV in a sample of breast cancer survivors. Methods : Women who had been diagnosed with early stage breast cancer before the age of 50 were recruited from the UCLA tumor registry and completed psychological questionnaires, including measures of fatigue. A subset of these women (n=30 participated in a follow-up study in which they completed measures of fatigue, energy and mood four times per day for 5 days using electronic diaries, provided 3 days of saliva samples for cortisol assessment and underwent physiological assessment including electrocardiogram (ECG. HRV was assessed via ECG R-R wave spectral and time sequence analysis. Results : Questionnaire measures of fatigue were negatively associated with indices of parasympathetic nervous system activity, B= − 3.85, p = 0.04 for RMSSD (root of the mean squared difference of successive normal to normal waves and B= − 76.97, p = 0.04 for LF power % (low-frequency wave power percentage. Daily fatigue was also associated with lower basal HRV, B= − 15.1, p = 0.04 for RMSSD. However, fatigue indices were not associated with sympathetic nervous system activity as measured by low- to high-frequency wave ratio. Of note, fatigue was not associated with average daily cortisol output (AUC. Conclusions : Lower HRV has been associated with increased chronic inflammation, which is elevated in cancer survivors reporting persistent fatigue, thus providing insight into

  13. Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone.

    Science.gov (United States)

    Todd, Henry; Galea, Gabriel L; Meakin, Lee B; Delisser, Peter J; Lanyon, Lance E; Windahl, Sara H; Price, Joanna S

    2015-01-01

    Genome Wide Association Studies suggest that Wnt16 is an important contributor to the mechanisms controlling bone mineral density, cortical thickness, bone strength and ultimately fracture risk. Wnt16 acts on osteoblasts and osteoclasts and, in cortical bone, is predominantly derived from osteoblasts. This led us to hypothesize that low bone mass would be associated with low levels of Wnt16 expression and that Wnt16 expression would be increased by anabolic factors, including mechanical loading. We therefore investigated Wnt16 expression in the context of ageing, mechanical loading and unloading, estrogen deficiency and replacement, and estrogen receptor α (ERα) depletion. Quantitative real time PCR showed that Wnt16 mRNA expression was lower in cortical bone and marrow of aged compared to young female mice. Neither increased nor decreased (by disuse) mechanical loading altered Wnt16 expression in young female mice, although Wnt16 expression was decreased following ovariectomy. Both 17β-estradiol and the Selective Estrogen Receptor Modulator Tamoxifen increased Wnt16 expression relative to ovariectomy. Wnt16 and ERβ expression were increased in female ERα-/- mice when compared to Wild Type. We also addressed potential effects of gender on Wnt16 expression and while the expression was lower in the cortical bone of aged males as in females, it was higher in male bone marrow of aged mice compared to young. In the kidney, which we used as a non-bone reference tissue, Wnt16 expression was unaffected by age in either males or females. In summary, age, and its associated bone loss, is associated with low levels of Wnt16 expression whereas bone loss associated with disuse has no effect on Wnt16 expression. In the artificially loaded mouse tibia we observed no loading-related up-regulation of Wnt16 expression but provide evidence that its expression is influenced by estrogen receptor signaling. These findings suggest that while Wnt16 is not an obligatory contributor to

  14. Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone.

    Directory of Open Access Journals (Sweden)

    Henry Todd

    Full Text Available Genome Wide Association Studies suggest that Wnt16 is an important contributor to the mechanisms controlling bone mineral density, cortical thickness, bone strength and ultimately fracture risk. Wnt16 acts on osteoblasts and osteoclasts and, in cortical bone, is predominantly derived from osteoblasts. This led us to hypothesize that low bone mass would be associated with low levels of Wnt16 expression and that Wnt16 expression would be increased by anabolic factors, including mechanical loading. We therefore investigated Wnt16 expression in the context of ageing, mechanical loading and unloading, estrogen deficiency and replacement, and estrogen receptor α (ERα depletion. Quantitative real time PCR showed that Wnt16 mRNA expression was lower in cortical bone and marrow of aged compared to young female mice. Neither increased nor decreased (by disuse mechanical loading altered Wnt16 expression in young female mice, although Wnt16 expression was decreased following ovariectomy. Both 17β-estradiol and the Selective Estrogen Receptor Modulator Tamoxifen increased Wnt16 expression relative to ovariectomy. Wnt16 and ERβ expression were increased in female ERα-/- mice when compared to Wild Type. We also addressed potential effects of gender on Wnt16 expression and while the expression was lower in the cortical bone of aged males as in females, it was higher in male bone marrow of aged mice compared to young. In the kidney, which we used as a non-bone reference tissue, Wnt16 expression was unaffected by age in either males or females. In summary, age, and its associated bone loss, is associated with low levels of Wnt16 expression whereas bone loss associated with disuse has no effect on Wnt16 expression. In the artificially loaded mouse tibia we observed no loading-related up-regulation of Wnt16 expression but provide evidence that its expression is influenced by estrogen receptor signaling. These findings suggest that while Wnt16 is not an

  15. A case of adenoid cystic carcinoma associated with IgG4-related disease

    OpenAIRE

    Tsuyoshi Shimo; Mayumi Yao; Yuichiro Takebe; Yuko Ono; Kyoichi Obata; Naito Kurio; Soichiro Ibaragi; Norie Yoshioka; Koji Kishimoto; Yoshinobu Yanagi; Hitoshi Nagatsuka; Akira Sasaki

    2015-01-01

    Introduction: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. We present a case of adenoid cystic carcinoma (ACC) of the submandibular gland with possible involvement of IgG4-RD. Presentation of case: The patient was a 59-year-old man presenting with a swollen right submandibular gland. Laboratory tests revealed IgG4 levels of 176 mg/dl (reference range: 4.8–105). An...

  16. Raman spectroscopy for rapid discrimination of Staphylococcus epidermidis clones related to medical device-associated infections

    International Nuclear Information System (INIS)

    We report on the potential application of Raman spectroscopy for the fast typing of Staphylococcus epidermidis (S. epidermidis) strains related to medical device-associated infections. In this study bacterial colonies were directly probed on culture plates and Raman spectra were recorded from volumes containing approximately 10 bacteria. The spectra contain information on the molecular composition of the whole bacteria, such as fatty acids, carbohydrates, proteins and nucleic acids, DNA as well as RNA. We demonstrate the potential to discriminate different S. epidermidis clones, even after only short Raman exposure/collection times

  17. Les relations entre syndicats et associations en Belgique : origines et actualité

    OpenAIRE

    Faniel, Jean

    2015-01-01

    Jean Faniel La Belgique compte davantage de syndiqués que la France, pour une population six fois moindre La nature et le poids du syndicalisme y sont sensiblement différents. Avec un taux de syndicalisation de 60 %, les organisations syndicales apparaissent comme des acteurs incontournables du champ social belge. Par conséquent, leurs relations avec les associations diffèrent à certains égards de ce qu'elles peuvent être en France. L'objet de ce texte est de brosser un tableau de ces relatio...

  18. Employment Is Associated with the Health-Related Quality of Life of Morbidly Obese Persons

    OpenAIRE

    Lund, Randi Størdal; Karlsen, Tor-Ivar; Hofsø, Dag; Fredheim, Jan Magnus; Røislien, Jo; Sandbu, Rune; Hjelmesæth, Jøran

    2010-01-01

    Background  We aimed to investigate whether employment status was associated with health-related quality of life (HRQoL) in a population of morbidly obese subjects. Methods  A total of 143 treatment-seeking morbidly obese patients completed the Medical Outcome Study 36-Item Short-Form Health Survey (SF-36) and the Obesity and Weight-Loss Quality of Life (OWLQOL) questionnaires. The former (SF-36) is a generic measure of physical and mental health status and the latter (OWLQOL) an obesity-spec...

  19. Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

    DEFF Research Database (Denmark)

    Hoeft, B.; Linseisen, J.; Beckmann, L.; Muller-Decker, K.; Canzian, F.; Husing, A.; Kaaks, R.; Vogel, Ulla Birgitte; Jakobsen, M.U.; Overvad, K.; Hansen, R.D.; Knuppel, S.; Boeing, H.; Trichopoulou, A.; Koumantaki, Y.; Trichopoulos, D.; Berrino, F.; Palli, D.; Panico, S.; Tumino, R.; Bueno-de-Mesquita, H.B.; van Duijnhoven, F.J.B.; van Gils, C.H.; Peeters, P.H.; Dumeaux, V.; Lund, E.; Castano, J.M.H.; Munoz, X.; Rodriguez, L.; Barricarte, A.; Manjer, J.; Jirstrom, K.; Van Guelpen, B.; Hallmans, G.; Spencer, E.A.; Crowe, F.L.; Khaw, K.T.; Wareham, N.; Morois, S.; Boutron-Ruault, M.C.; Clavel-Chapelon, F.; Chajes, V.; Jenab, M.; Boffetta, P.; Vineis, P.; Mouw, T.; Norat, T.; Riboli, E.; Nieters, A.

    2010-01-01

    as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three......Colorectal cancer (CRC) is the third most common malignant tumor and the fourth leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in-depth analysis of inter-individual differences in fatty acid metabolizing genes...

  20. Trauma-Related Reactivity and Regulation of Emotion: Associations with Posttraumatic Stress Symptoms

    Science.gov (United States)

    Badour, Christal L.; Feldner, Matthew T.

    2012-01-01

    Background and Objectives Both emotional reactivity to traumatic event cues and difficulties regulating emotion have been linked to posttraumatic stress symptom severity. The current study uniquely extended these two lines of research by examining the degree to which these two factors alone, and in combination, account for variability in posttraumatic stress symptom severity. Method Self-reported emotion regulation difficulties, and both subjective and physiological reactivity in response to a script-driven imagery procedure, were assessed among a community sample of 21 adult women with a history of interpersonal assault. Relationships with an interview-based measure of posttraumatic stress symptom severity were examined. Results Results were consistent with hypotheses. Both traumatic event-related emotional reactivity and emotion regulation difficulties independently predicted posttraumatic stress symptom severity. A significant interaction also emerged such that traumatic event-related emotional reactivity and posttraumatic stress symptom severity were only significantly associated at relatively elevated levels of emotion regulation difficulties. Limitations Limitations included the use of a self-report questionnaire to assess emotion regulation difficulties, relatively small sample size, and lack of evidence regarding generalizability across gender or other traumatic event types. Conclusions These results highlight that the interaction of heightened emotional reactivity and difficulties regulating emotion may be particularly influential in posttraumatic stress symptom severity. PMID:22922079

  1. The association between age and mortality related hospital expenditures: Evidence from a complete national registry

    Directory of Open Access Journals (Sweden)

    Fredrik Alexander Gregersen

    2014-01-01

    Full Text Available The aim of this paper is to contribute to the debate on population aging and growth in health expenditures, by providing precise estimates on how mortality related expenditures are influenced by age. Using a complete register of inpatient hospital admissions to create gender-cohort specific panels for each of the 430 Norwegian municipalities, we are able to identify mortality related hospital expenditures by separating the impact of mortality on current hospital expenditures from the impact of patients’ age and gender. We apply model estimates to quantify the mortality-related hospital expenditures for twenty age groups. The results suggest that mortality-related hospital expenditures are a decreasing function of age. Furthermore, the results clearly suggest that, both age and mortalities should be included when predicting future health care expenditures. The estimation results suggest that 9.2 % of all hospital expenditures is associated with treating individuals in their last year of life. Our results also suggest that the reduction in mortality rates in the period from 1998 to 2009 have, cet. par. contributed to an estimated reduction in total hospital expenditures of 0.6 billion NOK, a difference corresponding to 2 % of the expenditures in 2009. (The appendix can be found under "Supplementary Files" in the menu to the right

  2. Association between Blood Lead Levels and Age-Related Macular Degeneration.

    Directory of Open Access Journals (Sweden)

    Ho Sik Hwang

    Full Text Available To investigate the association between blood lead levels and prevalence of age-related macular degeneration (AMD.A nationwide population-based cross-sectional study included 4,933 subjects aged over 40 years who participated in the 2008-2012 Korean National Health and Nutrition Examination Survey, and for whom fundus photographs were available. All participants underwent a standardized interview, evaluation of blood lead concentration, and a comprehensive ophthalmic examination. Digital fundus photographs (45° were taken of both eyes under physiological mydriasis. All fundus photographs were graded using an international classification and grading system.Mean blood lead levels were 3.15 μg/dL in men and 2.27 μg/dL in women (P < 0.001. After adjusting for potential confounders including age, gender, smoking status, total cholesterol levels, triglyceride levels, heart problems and strokes, the adjusted odds ratio (OR in women for any AMD was 1.86 (95% Confidence Interval [CI], 1.03-3.36 and for early AMD was 1.92 (95% CI, 1.06-3.48, for those in the highest quintile of lead level compared with the lowest quintile. In men, however, blood lead level was not significantly associated with AMD.Blood lead levels were higher in men, but were only associated with AMD in women. Increased levels of blood lead may be involved in the pathogenesis of AMD development in women.

  3. Disease-association analysis of an inflammation-related feedback loop.

    Science.gov (United States)

    Murakami, Masaaki; Harada, Masaya; Kamimura, Daisuke; Ogura, Hideki; Okuyama, Yuko; Kumai, Noriko; Okuyama, Azusa; Singh, Rajeev; Jiang, Jing-Jing; Atsumi, Toru; Shiraya, Sayaka; Nakatsuji, Yuji; Kinoshita, Makoto; Kohsaka, Hitoshi; Nishida, Makoto; Sakoda, Saburo; Miyasaka, Nobuyuki; Yamauchi-Takihara, Keiko; Yamaguchi-Takihara, Keiko; Hirano, Toshio

    2013-03-28

    The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-6 stimulation in nonimmune cells. Subsequent results from animal models have shown that the amplifier is activated by stimulation of NFκB and STAT3 and induces chemokines and inflammation via an NFκB loop. However, its role in human diseases is unclear. Here, we combined two genome-wide mouse screens with SNP-based disease association studies, revealing 1,700 genes related to the IL-6 amplifier, 202 of which showed 492 indications of association with ailments beyond autoimmune diseases. We followed up on ErbB1 from our list. Blocking ErbB1 signaling suppressed the IL-6 amplifier, whereas the expression of epiregulin, an ErbB1 ligand, was higher in patients with inflammatory diseases. These results indicate that the IL-6 amplifier is indeed associated with human diseases and disorders and that the identified genes may make for potential therapeutic targets. PMID:23434511

  4. Abnormal liver function and central obesity associate with work-related fatigue among the Taiwanese workers

    Institute of Scientific and Technical Information of China (English)

    Yu-Cheng Lin; Jong-Dar Chen; Chao-Jen Chen

    2008-01-01

    AIM: TO examine the associations between objective health indicators and high need for recovery (NFR) after work, one of the subjective presentations of work related-fatigue, among apparently healthy workers in modern workplaces. METHODS: From October to December, 2007, an annual health examination was performed for the workers from an electronics manufacturing factory in Taiwan. Health records of 1216 workers with a relatively homogeneous socioeconomic status were used for analysis. The health checkups included personal and NFR scale questionnaires, physical examinations, blood tests for biochemistry and hematology. The workers within the top tertile NFR score were defined as high-NFR workers. RESULTS: After adjusted for potential confounders, the workers with elevated alanine aminotransferase (ALT) and central obesity had a significantly higher NFR after work, with increased risks of 1.4-fold [95% confidence interval (CI) = 1.01-2.0] and 1.8-fold (95% CI = 1.2-2.7), respectively. Shiftworkers had a 2.0-fold (95% CI = 1.5-2.6) increased risk for high-NFR. The associations between high-NFR and lipid profiles, blood sugar, hematology indexes or blood pressure were insignificant after controlling for confounders. CONCLUSION: For apparently healthy workers, high NFR after work is not simply a subjective experience. Objective health measures, such as elevated ALT and increased waist circumference, should be carefully evaluated for the apparently healthy workers having a higher NFR after work.

  5. Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis.

    LENUS (Irish Health Repository)

    Stevens, Niall T

    2009-07-01

    Staphylococcus epidermidis biofilm causes device-related meningitis in neurosurgical patients. This study assessed the contribution of polysaccharide and protein to the development of a strong biofilm-positive phenotype in four S. epidermidis isolates associated with probable device-related meningitis, under varying environmental conditions. RT-PCR analysis of the intercellular adhesion operon (icaADBC) and assessment of polysaccharide intercellular adhesin (PIA) production indicated a correlation between increased icaA transcription and PIA production in ica(+) isolates grown in medium with 4 % ethanol and 4 % NaCl. Treatment of biofilm with sodium metaperiodate caused dispersion of adhered cells (P <0.0001), indicating involvement of PIA. Transcriptional levels of protein factors revealed that atlE transcription levels were similar in all isolates, whilst aap levels were variable, with induction being seen in two isolates following growth in the presence of alcohol or salt. Transcription of agr did not influence protein expression and RNAIII transcription varied among the strains. Although aap transcription was induced, the treatment of biofilm with proteinase K did not always disperse the biofilm. Our data suggest that, among the three ica(+) S. epidermidis isolates clinically associated with meningitis that were studied, PIA contributed to the strong biofilm-positive phenotype, whereas protein factors appeared to have a secondary role.

  6. Initiation of CMEs associated with filament eruption, and the nature of CME related shocks

    Science.gov (United States)

    Fainshtein, V. G.; Egorov, Ya. I.

    2015-02-01

    Using data from SDO, PROBA2 and other spacecraft, Fainshtein and Egorov (2013) have discovered processes accompanying initiation of six limb CMEs and have studied features of their motion. The said CMEs occurred after eruption of prominence or hot emission loop and were associated with X-ray flares. The follow-up study of the CMEs, associated with the prominence eruption, showed that the formation of such mass ejections and the initial stage of their motion may be characterised by special features. In this work, we give examples of CMEs with such features. We have revealed a positive correlation between the height of the CME-related eruptive prominence and the height of the frontal structure of CMEs measured before they began to move. By analysing two of the CMEs, using SDO data, we found out that the kinematics of CME body and its related shock differs considerably. We have established that the time dependence of shock position and velocity obtained from SDO data is in agreement with theoretical dependencies of variation in these motion parameters with time in the context of self-similar motion of an explosion shock. We have concluded that the shock are not piston-like with the CME body acting as a piston.

  7. Factors Associated with Myelosuppression Related to Low-Dose Methotrexate Therapy for Inflammatory Rheumatic Diseases.

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    Shunsuke Mori

    Full Text Available Severe myelosuppression is a serious concern in the management of rheumatic disease patients receiving methotrexate (MTX therapy. This study was intended to explore factors associated with the development of MTX-related myelosuppression and its disease severity.We retrospectively examined a total of 40 cases of MTX-related myelosuppression that had been filed in the registries of participating rheumatology and hematology divisions. Data before onset were compared with those of 120 controls matched for age and sex. Cytopenia was graded according to the National Cancer Institute criteria for adverse events. Data before and at onset were compared between the severe and non-severe groups.Non-use of folic acid supplements, concurrent medications, and low renal function were significantly associated with the development of myelosuppression (p < 0.001, p < 0.001, and p = 0.002, respectively. In addition, significantly lower MTX dosages, higher blood cell counts, and lower hemoglobin levels were seen in the myelosuppression group (p < 0.001. No patients exhibited leukocytopenia, neutropenia, or thrombocytopenia in routine blood monitoring taken within the past month. One-fourth developed myelosuppression within the first two months (an early-onset period. Myelosuppression was severe in approximately 40% of patients. Hypoalbuminemia and non-use of folic acid supplements were significantly associated with the severity of pancytopenia (p = 0.001 and 0.008, respectively. Besides these two factors, early onset and the use of lower doses of MTX were significantly associated with the severity of neutropenia (p = 0.003, 0.007, 0.003, and 0.002, respectively.Myelosuppression can occur abruptly at any time during low-dose MTX therapy, but severe neutropenia is more likely to occur in the early-onset period of this therapy. Contrary to our expectations, disease severity was not dependent on MTX doses. Serum albumin levels and folic acid supplementation are the

  8. Relating the shape of protein binding sites to binding affinity profiles: is there an association?

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    Bitter István

    2010-10-01

    , except for few specific cases, the shapes of the binding pockets have relatively low weights in the determination of the affinity profiles of proteins. Since the MAF profile is closely related to the target specificity of ligand binding sites we can conclude that the shape of the binding site is not a pivotal factor in selecting drug targets. Nonetheless, based on strong specific associations between certain MAF profiles and specific geometric descriptors we identified, the shapes of the binding sites do have a crucial role in virtual drug design for certain drug categories, including morphine derivatives, benzodiazepines, barbiturates and antihistamines.

  9. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.

    Directory of Open Access Journals (Sweden)

    Gary W Beecham

    2014-09-01

    Full Text Available Alzheimer's disease (AD and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies. Neuropathologic data were used to define clinico-pathologic AD dementia or controls, assess core neuropathologic features of AD (neuritic plaques, NPs; neurofibrillary tangles, NFTs, and evaluate commonly co-morbid neuropathologic changes: cerebral amyloid angiopathy (CAA, Lewy body disease (LBD, hippocampal sclerosis of the elderly (HS, and vascular brain injury (VBI. Genome-wide significance was observed for clinico-pathologic AD dementia, NPs, NFTs, CAA, and LBD with a number of variants in and around the apolipoprotein E gene (APOE. GalNAc transferase 7 (GALNT7, ATP-Binding Cassette, Sub-Family G (WHITE, Member 1 (ABCG1, and an intergenic region on chromosome 9 were associated with NP score; and Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 2 (KCNMB2 was strongly associated with HS. Twelve of the 21 non-APOE genetic risk loci for clinically-defined AD dementia were confirmed in our clinico-pathologic sample: CR1, BIN1, CLU, MS4A6A, PICALM, ABCA7, CD33, PTK2B, SORL1, MEF2C, ZCWPW1, and CASS4 with 9 of these 12 loci showing larger odds ratio in the clinico-pathologic sample. Correlation of effect sizes for risk of AD dementia with effect size for NFTs or NPs showed positive correlation, while those for risk of VBI showed a moderate negative correlation. The other co-morbid neuropathologic features showed only nominal association with the known AD loci. Our results discovered new genetic associations with specific neuropathologic features and aligned known genetic risk for AD dementia with specific neuropathologic changes in the largest brain autopsy study of AD and related

  10. Bone mineral density-associated polymorphisms are associated with obesity-related traits in Korean adults in a sex-dependent manner.

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    Seongwon Cha

    Full Text Available Obesity and osteoporosis share common physiological factors, including the presence of atherosclerosis, a risk factor for cardiometabolic disease, as well as a common progenitor that differentiates into both adipocytes and osteoblasts. Among the 23 polymorphisms associated with bone mineral density (BMD in recent genome-wide association studies (GWASs, an Osterix polymorphism has been identified and associated with childhood obesity in girls. Therefore, we focused on elucidating polymorphisms associated with adulthood obesity in a sex-dependent manner among the previously published BMD-associated polymorphisms from GWASs. We performed 2 screenings of 18 BMD-associated polymorphisms for obesity-related traits in 2,362 adults aged >20 years. We excluded 13 polymorphisms showing deviations from Hardy-Weinberg equilibrium or no association with obesity-related traits (body mass index, waist circumference (WC, and waist-to-hip ratio. Among 5 selected polymorphisms (rs9594738 of RANKL, rs17066364 of NUFIP1, rs7227401 of OSBPL1A, and rs1856057 and rs2982573 of ESR1 analyzed, 2 polymorphisms (rs9594738 and rs17066364 were associated with obesity-related traits. We found sex-dependent associations such that the 4 polymorphisms (excluding rs9594738 of RANKL were associated with abdominal traits such as WC and waist-to-hip ratio only in men. In addition, when the combined genetic risk score (GRS for WC increase was calculated with 4 SNPs (rs9594738, rs17066364, rs7227401, and rs1856057 exhibiting similar trends for both sexes, the magnitude of the GRS effect for the WC increase was larger in men than in women (effect size = 0.856 cm, P = 0.0000452 for men; effect size = 0.598 cm, P = 0.00228 for women. In summary, we found 4 polymorphisms, previously related to osteoporosis, to be associated to obesity-related traits in a sex-dependent manner in Korean adults, particularly in men.

  11. Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score.

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    Jiun-Chi Huang

    Full Text Available BACKGROUND AND AIM: Metabolic syndrome (MetS, albuminuria, and the Framingham Risk Score (FRS are significant predictors for cardiovascular disease (CVD. However, the relationship and clinical significance of these CVD predictors in individuals with a family history of end-stage renal disease (ESRD are unclear. We investigated the association of relatives of hemodialysis (HD patients with MetS, albuminuria, and the FRS. METHODS: One hundred and sixty-six relatives of HD patients and 374 age- and sex- matched community controls were enrolled. MetS was defined using the Adult Treatment Panel III for Asians. Albuminuria was defined as urine albumin-to-creatinine ratio ≥ 30 mg/g. CVD risk was evaluated by the FRS. RESULTS: A significantly higher prevalence of MetS (19.9% vs. 12.5%, P = 0.026, albuminuria (12.7% vs. 5.1%, P = 0.002 and high FRS risk ≥ 10% of 10-year risk (15.7% vs. 8.5%, P = 0.013 was found in relatives of HD patients compared to their counterpart controls. In multivariate analysis, being relatives of HD patients (vs. controls was an independent determinant for MetS (odds ratio [OR], 1.785; 95% confidence interval [CI], 1.045 to 3.050, albuminuria (OR, 2.891; 95% CI, 1.431 to 5.841, and high FRS risk (OR, 1.863; 95% CI, 1.015 to 3.418. Higher low-density lipoprotein cholesterol (OR, 1.034; 95% CI, 1.017 to 1.052 and betel nut chewing (OR, 13.994; 95% CI, 3.384 to 57.871 were independent determinants for having a high FRS risk in relatives of HD patients. CONCLUSIONS: Being relatives of HD patients was independently associated with MetS, albuminuria and high FRS risk, suggesting family members of ESRD patients may have higher CVD risks through the interactions of renal risk factors. Proactive surveillance of these CVD predictors and preventive strategies should be targeted to this high-risk population.

  12. Climate sensitivity of allergenic taxa in Central Europe associated with new climate change related forces.

    Science.gov (United States)

    Deák, Aron József; Makra, László; Matyasovszky, István; Csépe, Zoltán; Muladi, Beáta

    2013-01-01

    The aim of the study was to analyse trends of the pollen season with its duration, start and end dates, as well as trends of the annual total pollen count and annual peak pollen concentration for the Szeged agglomeration in Southern Hungary. The data set covered an 11-year period (1997-2007) that included eight taxa and seven daily climate variables. Trend analysis was performed on both annual and daily bases. Trend analysis on a daily basis is a new approach that provides information on the annual cycles of the trends. To quantify the strength of the relationship between the annual cycle of the slope of a pollen concentration trend and the annual cycles of the slopes of the climate variable trends, an association measure and a multiple association measure are introduced. Individual taxa were sorted into three categories according to their climate sensitivities. These were compared with two novel climate change-related forces, namely risk potential and expansion potential due to the climate change. The total annual pollen counts indicated significant trends for 4 taxa and 3 of these 4 trends increased on a daily basis. At the same time, significant changes were detected for the pollen season characteristics of three taxa. The association measures performed well when compared to the climate change-related forces. Significant changes in pollen season characteristics were also in accordance with the risk potential and expansion potential due to the climate change. A novel procedure was applied to separate the effects of the past and current weather conditions that influence the current Ambrosia pollen concentrations. The potential effect of land use changes on pollen release of the given taxa was also discussed using the CORINE Land Cover Database. PMID:23178762

  13. Age and intrusive relations of the Lamarck granodiorite and associated mafic plutons, Sierra Nevada, California

    Energy Technology Data Exchange (ETDEWEB)

    Joye, J.L.; Bachl, C.A.; Miller, J.S.; Glazner, A.F. (Univ. of North Carolina, Chapel Hill, NC (United States). Dept. of Geology); Frost, T.P. (Geological Survey, Spokane, WA (United States)); Coleman, D.S. (Massachusetts Inst. of Tech., Cambridge, MA (United States). Dept. of Earth, Atmospheric and Planetary Sciences)

    1993-04-01

    The compositionally zoned Late Cretaceous Lamarck granodiorite, west of Bishop, hosts numerous mafic intrusions ranging from hornblende gabbro to mafic granodiorite. Frost and Mahood (1987) suggested from field relations that the Lamarck and the associated mafic plutons were co-intrusive. Contact relations between the Lamarck host and the mafic intrusions are variable (sharp to diffuse) and in places suggest commingling. In order to constrain the intrusive relationships between the Lamarck and its associated mafic plutons, the authors have analyzed feldspars from the Mt. Gilbert pluton and the Lamarck granodiorite to see if feldspar compositions in the Mt. Gilbert overlap those in the Lamarck host and determined U-Pb zircon ages for the Mt. Gilbert and Lake Sabrina plutons to see if they have the same age as the Lamarck granodiorite. Feldspars from the Lamarck granodiorite are normally zoned and range compositionally from An[sub 38--32]; those in the Mt. Gilbert diorite are also normally zoned but range compositionally from An[sub 49--41] and do not overlap the Lamarck host. Four to five zircon fractions from each pluton were handpicked and dated using U-Pb methods. The Mt. Gilbert mafic diorite has a concordant age of 92.5 Ma and the Lake Sabrina diorite has a concordant age of 91.5 Ma. Ages for the two plutons overlap within error, but multiple fractions from each suggest that the Lake Sabrina pluton is slightly younger than the Mt. Gilbert pluton. These data and field relationships indicate: (1) plagioclase phenocrysts in the Mt. Gilbert pluton were not derived from the Lamarck granodiorite despite their textural similarity; but (2) the Lamarck granodiorite and its associated mafic plutons are co-intrusive as supported by the close agreement of the ages with the crystallization age obtained by Stern and others for the Lamarck granodiorite.

  14. Low heart rate variability is associated with extended pain-related sick leave among employed care-seekers

    DEFF Research Database (Denmark)

    Kristiansen, Jesper; Ektor-Andersen, John; Bondesson, Elisabeth; Orbæk, Palle; Persson, Roger; Garde, Anne Helene; Hansen, Åse Marie

    2011-01-01

    To examine the association between autonomic regulation and length of pain-related sick leave in subjects receiving a cognitive behavioural therapy-based return to work intervention.......To examine the association between autonomic regulation and length of pain-related sick leave in subjects receiving a cognitive behavioural therapy-based return to work intervention....

  15. Age-related impairments in object-place associations are not due to hippocampal dysfunction.

    Science.gov (United States)

    Hernandez, Abigail R; Maurer, Andrew P; Reasor, Jordan E; Turner, Sean M; Barthle, Sarah E; Johnson, Sarah A; Burke, Sara N

    2015-10-01

    Age-associated cognitive decline can reduce an individual's quality of life. As no single neurobiological deficit can account for the wide spectrum of behavioral impairments observed in old age, it is critical to develop an understanding of how interactions between different brain regions change over the life span. The performance of young and aged animals on behaviors that require the hippocampus and cortical regions to interact, however, has not been well characterized. Specifically, the ability to link a spatial location with specific features of a stimulus, such as object identity, relies on the hippocampus, perirhinal and prefrontal cortices. Although aging is associated with dysfunction in each of these brain regions, behavioral measures of functional change within the hippocampus, perirhinal and prefrontal cortices in individual animals are often not correlated. Thus, how dysfunction of a single brain region within this circuit, such as the hippocampus, impacts behaviors that require communication with the perirhinal and prefrontal cortices remains unknown. To address this question, young and aged rats were tested on the interregion dependent object-place paired association task, as well as a hippocampal-dependent test of spatial reference memory. This particular cohort of aged rats did not show deficits on the hippocampal-dependent task, but were significantly impaired at acquiring object-place associations relative to young. These data suggest that behaviors requiring functional connectivity across different regions of the memory network may be particularly sensitive to aging, and can be used to develop models that will clarify the impact of systems-level dysfunction in the elderly. PMID:26413723

  16. Parents' experience of flooding in discipline encounters: Associations with discipline and interplay with related factors.

    Science.gov (United States)

    Lorber, Michael F; Mitnick, Danielle M; Slep, Amy M Smith

    2016-06-01

    In family psychology, the term flooding refers to the feeling of being overwhelmed by a family member's behavior in a manner that undermines an organized response. In the present investigation we first aimed to clarify the role of flooding in overreactive and lax discipline. The second study aim was to more fully establish the position of parental flooding in its nomological network given the relative paucity of research on parental flooding. Maternal discipline and physiological responses, as well as child behavior, were observed in laboratory discipline encounters with 97 mother-toddler dyads. Mothers then rated the extent to which they experienced flooding in response to their children's behavior and emotion displays during the immediately preceding discipline encounters. Mothers' experience of negative emotion was assessed via video-mediated recall. Flooding was positively associated with both overreactive and lax discipline; this association did not reflect confounding by mothers' experience of negative emotion. Flooding was further associated with mothers' experienced negative emotion and heart rate reactivity, as well as child misbehavior and negative emotion displays. The flooding-overreactive discipline association was concentrated in those mothers who exhibited greater increases in heart rate and greater vagal withdrawal, and whose children misbehaved more during the discipline encounter. The present results suggest the incremental validity of flooding in predicting discipline practices, as well as the strong fit of flooding in its nomological network. Parents' self-recognition of flooding may ultimately prove useful in parenting interventions as a signal to trigger compensatory techniques. (PsycINFO Database Record PMID:26690330

  17. Prevalence and Associated Factors of Physical, Verbal and Relational Aggression among Iranian Preschoolers

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    Alipasha Meysamie

    2013-09-01

    Full Text Available Objective:Childhood aggression may lead to severe social disorders in adolescence and adulthood. Different psychiatric approaches are focused on preschool aged aggressive children. The aim of this study was to estimate the prevalence and associated factors of childhood direct and indirect aggression Methods:In this cross sectional study a total of 1403 children attending 43 kindergartens were assessed. Data were collected through a structured 46-item questionnaire investigating symptoms of physical, verbal and relational aggression which was completed by parents and teachers of day-care centers. Complex sample survey analysis and multivariate logistic regression method were used for data analysis. Results:According to parents’rating, the prevalence of physical ,verbal and relational aggression, was 9.9% (95% CI=7.4%-12.4% , 6.3% (95% CI=5.0% -7.6% and 1.6% (95%CI=1.0%-2.2%, respectively; while based on teachers’ rating the prevalence of physical ,verbal and relational aggression were 10.9% (95% CI=8.9% -12.9%, 4.9%(95% CI=3.8% - 6.0% and 6% (95% CI=4.4% -7.6%, respectively. A wide range of family environment factors including living with a single parent, having a working mother, death of someone close to the child, and having less educated mother were significantly associated with different types of aggression; additionally, there was some evidence of a relationship between sex of the children and physical aggression, after controlling for other variables (p<0.05.Conclusion:This study revealed that children’s family environment alongside internal factors plays an important role as an external factor in determining the child’s potential aggressive behavior. Given this, to better prevent the aggressive behavior of children, intervention strategies should be planned for families and caregivers; specially mothers should receive training to use such strategies.

  18. Expression of Root-Related Transcription Factors Associated with Flooding Tolerance of Soybean (Glycine max

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    Babu Valliyodan

    2014-09-01

    Full Text Available Much research has been conducted on the changes in gene expression of the model plant Arabidopsis to low-oxygen stress. Flooding results in a low oxygen environment in the root zone. However, there is ample evidence that tolerance to soil flooding is more than tolerance to low oxygen alone. In this study, we investigated the physiological response and differential expression of root-related transcription factors (TFs associated with the tolerance of soybean plants to soil flooding. Differential responses of PI408105A and S99-2281 plants to ten days of soil flooding were evaluated at physiological, morphological and anatomical levels. Gene expression underlying the tolerance response was investigated using qRT-PCR of root-related TFs, known anaerobic genes, and housekeeping genes. Biomass of flood-sensitive S99-2281 roots remained unchanged during the entire 10 days of flooding. Flood-tolerant PI408105A plants exhibited recovery of root growth after 3 days of flooding. Flooding induced the development of aerenchyma and adventitious roots more rapidly in the flood-tolerant than the flood-sensitive genotype. Roots of tolerant plants also contained more ATP than roots of sensitive plants at the 7th and 10th days of flooding. Quantitative transcript analysis identified 132 genes differentially expressed between the two genotypes at one or more time points of flooding. Expression of genes related to the ethylene biosynthesis pathway and formation of adventitious roots was induced earlier and to higher levels in roots of the flood-tolerant genotype. Three potential flood-tolerance TFs which were differentially expressed between the two genotypes during the entire 10-day flooding duration were identified. This study confirmed the expression of anaerobic genes in response to soil flooding. Additionally, the differential expression of TFs associated with soil flooding tolerance was not qualitative but quantitative and temporal. Functional analyses of

  19. Cell Phone-Related Near Accidents Among Young Drivers: Associations With Mindfulness.

    Science.gov (United States)

    Terry, Christopher P; Terry, Danielle L

    2015-01-01

    Cell phone use while driving (CPWD) has been shown to significantly reduce driver safety. This is a particular concern among young drivers who possess less driving experience and tend to engage in high rates of cell phone use. The present study identified psychological predictors of near accidents related to CPWD among a sample of 385 college student drivers. Participants answered a series of questions regarding their use of a cell phone while driving and completed measures of mindfulness, polychronicity, and intrusive thinking. Students who reported talking on their phone or texting more frequently while driving reported a higher incidence of near accidents related to each behavior. However, after controlling for CPWD, multiple regression analysis indicated that those who reported experiencing more cell phone-related intrusive thoughts also experienced more near accidents. Furthermore, two facets of mindfulness--acting with awareness and nonjudging of inner experience--were negatively associated with near accidents. These findings suggest that individuals who are more aware of the present moment and accepting of their affective responses may better regulate their attention while using a cell phone behind the wheel. PMID:25365542

  20. The association of drooling and health-related quality of life in children with cerebral palsy

    Directory of Open Access Journals (Sweden)

    Chang SC

    2012-12-01

    Full Text Available Shih-Chung Chang,1 Chin-Kai Lin,2 Li-Chen Tung,3 Nai-Yin Chang11Department of Physical Medicine and Rehabilitation, School of Medicine, Chung Shang Medical University Hospital, Taichung, Taiwan; 2Program of Early Intervention, Department of Early Childhood Education, National Taichung University of Education, Taichung, Taiwan; 3Department of Physical Medicine and Rehabilitation, Chi Mei Medical Center, Tainan, TaiwanObjective: To investigate the association between drooling in children with cerebral palsy (CP and their health-related quality of life (HRQOL, as well as the possible variables that predict their HRQOL.Method: A cross-sectional design was used for this study. Children with CP, without other identified disease, aged 2 to 6 years, who drool (n = 33 or did not drool (n = 14, were included. The dependent variables were the physical health summary scores and the psychosocial health summary scores of the Pediatric Quality of Life Inventory version 4.0. The t test, Pearson product–moment correlation, Mann–Whitney U test and stepwise regression analysis were used for statistical analysis.Results: The physical health and psychosocial health summary scores of the children that drooled (16.29 ± 15.97 and 42.92 ± 17.57, respectively were lower than for the children that did not drool (31.97 ± 22.22 and 57.09 ± 12.21, respectively; P < 0.01. The drooling ranking score was negatively correlated with the physical health summary score (r = −0.355; P < 0.05 and the psychosocial health summary score (r = −0.381; P < 0.01. The stepwise regression showed that gross motor development and the drooling ranking score predicted 56.6% of the variability of the physical health summary score (R2 = 0.566; P < 0.01. The language development score predicted 25.6% of the variability of the psychosocial health summary score (R2 = 0.256; P < 0.01.Conclusion: Drooling was associated with a lower HRQOL. Prediction of the physical health summary score was

  1. Genome-wide association study of neocortical Lewy-related pathology

    Science.gov (United States)

    Peuralinna, Terhi; Myllykangas, Liisa; Oinas, Minna; Nalls, Mike A; Keage, Hannah A D; Isoviita, Veli-Matti; Valori, Miko; Polvikoski, Tuomo; Paetau, Anders; Sulkava, Raimo; Ince, Paul G; Zaccai, Julia; Brayne, Carol; Traynor, Bryan J; Hardy, John; Singleton, Andrew B; Tienari, Pentti J

    2015-01-01

    Objective Dementia with Lewy bodies is an α-synucleinopathy characterized by neocortical Lewy-related pathology (LRP). We carried out a genome-wide association study (GWAS) on neocortical LRP in a population-based sample of subjects aged 85 or over. Methods LRP was analyzed in 304 subjects in the Vantaa 85+ sample from Southern Finland. The GWAS included 41 cases with midbrain, hippocampal, and neocortical LRP and 177 controls without midbrain and hippocampal LRP. The Medical Research Council Cognitive Function and Ageing Study (CFAS) material was used for replication (51 cases and 131 controls). Results By analyzing 327,010 markers the top signal was obtained at the HLA-DPA1/DPB1 locus (P = 1.29 × 10−7); five other loci on chromosomes 15q14, 2p21, 2q31, 18p11, and 5q23 were associated with neocortical LRP at P < 10−5. Two loci were marked by multiple markers, 2p21 (P = 3.9 × 10−6, upstream of the SPTBN1 gene), and HLA-DPA1/DPB1; these were tested in the CFAS material. Single marker (P = 0.0035) and haplotype (P = 0.04) associations on 2p21 were replicated in CFAS, whereas HLA-DPA1/DPB1 association was not. Bioinformatic analyses suggest functional effects for the HLA-DPA1/DPB1 markers as well as the 15q14 marker rs8037309. Interpretation We identified suggestive novel risk factors for neocortical LRP. SPTBN1 is the candidate on 2p21, it encodes beta-spectrin, an α-synuclein binding protein and a component of Lewy bodies. The HLA-DPA1/DPB1 association suggests a role for antigen presentation or alternatively, cis-regulatory effects, one of the regulated neighboring genes identified here (vacuolar protein sorting 52) plays a role in vesicular trafficking and has been shown to interact with α-synuclein in a yeast model. PMID:26401513

  2. Dietary factors impact on the association between CTSS variants and obesity related traits.

    Directory of Open Access Journals (Sweden)

    Henri Hooton

    Full Text Available BACKGROUND/AIMS: Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology--this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors--increased by high protein, glycemic index and energy diets. METHODS: Four tag SNPs (rs7511673, rs11576175, rs10888390 and rs1136774 were selected to capture all common variation in the CTSS region. Association between these four SNPs and several adiposity measurements (BMI, waist circumference, waist for given BMI and being a weight gainer-experiencing the greatest degree of unexplained annual weight gain during follow-up or not given, where applicable, both as baseline values and gain during the study period (6-8 years were tested in 11,091 European individuals (linear or logistic regression models. We also examined the interaction between the CTSS variants and dietary factors--energy density, protein content (in grams or in % of total energy intake and glycemic index--on these four adiposity phenotypes. RESULTS: We found several associations between CTSS polymorphisms and anthropometric traits including baseline BMI (rs11576175 (SNP N°2, p = 0.02, β = -0.2446, and waist change over time (rs7511673 (SNP N°1, p = 0.01, β = -0.0433 and rs10888390 (SNP N°3, p = 0.04, β = -0.0342. In interaction with the percentage of proteins contained in the diet, rs11576175 (SNP N°2 was also associated with the risk of being a weight gainer (p(interaction = 0.01, OR = 1.0526--the risk of being a weight gainer increased with the percentage of proteins contained in the diet. CONCLUSION: CTSS variants seem to be nominally associated to obesity related traits and this association may be modified by dietary protein intake.

  3. Heterogeneity of Relational Backgrounds is Associated With Variation in Non-Suicidal Self-Injurious Behavior.

    Science.gov (United States)

    Martin, Jodi; Bureau, Jean-François; Yurkowski, Kim; Lafontaine, Marie-France; Cloutier, Paula

    2016-04-01

    Non-suicidal self-injury (NSSI) is a self-destructive behavior of common prevalence in adolescence and young adulthood. Engagement in NSSI has been consistently linked in the literature with perceptions of one's parent-child relationships as negative or invalidating. However, the potential for multiple combinations of such relational characteristics to be associated with varying cognitive and behavioral manifestations of NSSI remains uninvestigated. In the current study, a person-centered approach to studying perceived parent-child relationship quality and NSSI was adopted; functions and behavioral severity of NSSI were then compared across the different relational profiles created. A latent profile analysis in a sample of 264 self-injuring university students (205 females; m(age) = 19.37 years, sd = 1.50) revealed four distinct profiles, two characterized by negative parent-child perceptions and two by positive parent-child perceptions. The perceived relational dimensions of these profiles were unique compared to a parallel group of 264 non-self-injurers (207 females; m(age) = 19.27 years, sd = 1.33). Participants reporting negative parent-child relationships endorsed more severe NSSI, and engaged in NSSI to regulate aggressive emotions. In contrast, individuals reporting positive parent-child relationships engaged in less extreme manifestations of NSSI overall, suggesting lower psychological deficits. Findings suggest that, although not all self-injurers perceive their relationships with parents negatively, variation in the perception of relational quality is implicated in behavioral and cognitive variation in NSSI engagement. PMID:26133094

  4. The Association Between Functional Status, Health Related Quality of Life and Depression After Stroke

    Directory of Open Access Journals (Sweden)

    Özlem Altındağ

    2008-10-01

    Full Text Available Objective: Stroke is a major cause of disability, and assessment of quality of life is important in patients after suffering a stroke. Psychological disorders may be associated with poor quality of life and lower functional status after stroke. The objective of the study was to determine the relation between health-related quality of life, functional status, and depressive symptoms in stroke patients. Materials and Methods: Subjects consisted of fourty patients who were being treated in the rehabilitation program in the Department of Physical Medicine and Rehabilitation at Harran University Research Hospital. Health-related quality of life was assessed using Short Form 36 (SF-36, functional status using the Stroke Adapted Sickness Impact Profile (SA-SIP, and depressive symptoms using Beck’s Depression Inventory (BDI.Results: BDI scores were negatively correlated with physical functioning, role limitations due to physical problems, emotional problems, and mental health subscales of SF-36 (p=0.002, r=-0.474; p=0.008, r=-0.417; p=0.01, r=-0.369; p=0.03, r=-0.369, respectively. Furthermore, BDI scores were positively correlated with Communication, Ambulation, and Emotional Behavior subscale scores of SA-SIP (p=0.03, r=0.347; p=0.002, r=0.483; p=0.001, r=0.502, respectively.Conclusion: Depressive symptoms are common, and the severity of depression may be related to poor functional status and quality of life in stroke patients. Assessment, recognition and management of depression may facilitate the participation of stroke patients in rehabilitation programs. Turk J Phys Med Rehab 2008;54:89-91.

  5. RELATED GENES IN LUNG CANCER TISSUES ASSOCIATED WITH RESIDENTIAL HIGH RADON EXPOSURE

    Institute of Scientific and Technical Information of China (English)

    夏英; 杨梅英; 张守志; 叶常青

    2002-01-01

    Objective: To investigate the related genes in lung cancer tissues associated with residential high radon exposure. Methods: Differentially expressed gene fragments in lung cancer and normal lung tissues were discovered by differential display and reverse Northern blot hybridization method. The fragments positive in lung cancer and negative in normal lung tissue were determined. Results: Seven differential displayed fragments were sequenced. One of them named NA7 is 95% homologous with AI208667 in EAT of Genbank. Another fragment named NG2 is up to 98% homologous with five fragments. The remained one CA1 may be a new gene fragment. Conclusion: 3 gene fragments were discovered from lung cancer and normal lung tissues of high radon exposure resident.

  6. Association of gait and balance disorders with age-related white matter changes: the LADIS study

    DEFF Research Database (Denmark)

    Baezner, H.; Blahak, C.; Poggesi, A.; Pantoni, L.; Inzitari, D.; Chabriat, H.; Erkinjuntti, T.; Fazekas, F.; Ferro, J.M.; Langhorne, P.; O'Brien, J.; Scheltens, P.; Visser, M.C.; Wahlund, L.O.; Waldemar, G.; Wallin, A.; Hennerici, M.G.

    2008-01-01

    % CI 1.02 to 2.52; severe vs mild ARWMC: odds ratio 1.75, 95% CI 1.09 to 2.80). CONCLUSIONS: Our findings support a strong association between the severity of age-related white matter changes and the severity of gait and motor compromise. Physical activity might have the potential to reduce the risk of...... different objective measures of gait and balance. METHODS: Six hundred thirty-nine nondisabled individuals were prospectively enrolled and are being followed-up for 3 years. Subjects are graded in three standardized categories of ARWMC (mild, moderate, and severe) according to central MRI reading....... Quantitative tests of gait and balance include the Short Physical Performance Battery (SPPB; range: 0 [poor] to 12 [normal]), a timed 8-m walk, and a timed single leg stance test. RESULTS: In cross-sectional analysis, deficiencies in gait and balance performance were correlated with the severity of ARWMC (SPPB...

  7. AN EVALUATION APPROACH FOR THE PROGRAM OF ASSOCIATION RULES ALGORITHM BASED ON METAMORPHIC RELATIONS

    Institute of Scientific and Technical Information of China (English)

    Zhang Jing; Hu Xuegang; Zhang Bin

    2011-01-01

    As data mining more and more popular applied in computer system,the quality assurance test of its software would be get more and more attention.However,because of the existence of the ‘oracle' problem,the traditional test method is not ease fit for the application program in the field of the data mining.In this paper,based on metamorphic testing,a software testing method is proposed in the field of the data mining,makes an association rules algorithm as the specific case,and constructs the metamorphic relation on the algorithm.Experiences show that the method can achieve the testing target and is feasible to apply to other domain.

  8. Alcohol and relatively pure cannabis use, but not schizotypy, are associated with cognitive attenuations

    Directory of Open Access Journals (Sweden)

    Daniela A Herzig

    2014-09-01

    Full Text Available Elevated schizotypy relates to similar cognitive attenuations as seen in psychosis and cannabis/polydrug use. Also, in schizotypal populations cannabis and polydrug (including licit drug use are enhanced. These cognitive attenuations may therefore either be a behavioural marker of psychotic (-like symptoms or the consequence of an enhanced drug use in schizotypal populations. To elucidate this, we investigated the link between cognitive attenuation and cannabis use in largely pure cannabis users (35 CU and non-using controls (48 nCU, accounting for the potential additional influence of both schizotypy and licit drug use (alcohol, nicotine. Cognitive attenuations commonly seen in psychosis were associated with cannabis and alcohol use, but not schizotypy. Future studies should therefore consider i non-excessive licit substance use (e.g. alcohol in studies investigating the effect of cannabis use on cognition and ii both enhanced illicit and licit substance use in studies investigating cognition in schizotypal populations.

  9. Comparative Transcriptomics Reveals Jasmonic Acid-Associated Metabolism Related to Cotton Fiber Initiation.

    Directory of Open Access Journals (Sweden)

    Liman Wang

    Full Text Available Analysis of mutants and gene expression patterns provides a powerful approach for investigating genes involved in key stages of plant fiber development. In this study, lintless-fuzzless XinWX and linted-fuzzless XinFLM with a single genetic locus difference for lint were used to identify differentially expressed genes. Scanning electron microscopy showed fiber initiation in XinFLM at 0 days post anthesis (DPA. Fiber transcriptional profiling of the lines at three initiation developmental stages (-1, 0, 1 DPA was performed using an oligonucleotide microarray. Loop comparisons of the differentially expressed genes within and between the lines was carried out, and functional classification and enrichment analysis showed that gene expression patterns during fiber initiation were heavily associated with hormone metabolism, transcription factor regulation, lipid transport, and asparagine biosynthetic processes, as previously reported. Further, four members of the allene-oxide cyclase (AOC family that function in jasmonate biosynthesis were parallel up-regulation in fiber initiation, especially at -1 DPA, compared to other tissues and organs in linted-fuzzed TM-1. Real time-quantitative PCR (RT-qPCR analysis in different fiber mutant lines revealed that AOCs were up-regulated higher at -1 DPA in lintless-fuzzless than that in linted-fuzzless and linted-fuzzed materials, and transcription of the AOCs was increased under jasmonic acid (JA treatment. Expression analysis of JA biosynthesis-associated genes between XinWX and XinFLM showed that they were up-regulated during fiber initiation in the fuzzless-lintless mutant. Taken together, jasmonic acid-associated metabolism was related to cotton fiber initiation. Parallel up-regulation of AOCs expression may be important for normal fiber initiation development, while overproduction of AOCs might disrupt normal fiber development.

  10. Mouse Social Network Dynamics and Community Structure are Associated with Plasticity-Related Brain Gene Expression.

    Science.gov (United States)

    Williamson, Cait M; Franks, Becca; Curley, James P

    2016-01-01

    Laboratory studies of social behavior have typically focused on dyadic interactions occurring within a limited spatiotemporal context. However, this strategy prevents analyses of the dynamics of group social behavior and constrains identification of the biological pathways mediating individual differences in behavior. In the current study, we aimed to identify the spatiotemporal dynamics and hierarchical organization of a large social network of male mice. We also sought to determine if standard assays of social and exploratory behavior are predictive of social behavior in this social network and whether individual network position was associated with the mRNA expression of two plasticity-related genes, DNA methyltransferase 1 and 3a. Mice were observed to form a hierarchically organized social network and self-organized into two separate social network communities. Members of both communities exhibited distinct patterns of socio-spatial organization within the vivaria that was not limited to only agonistic interactions. We further established that exploratory and social behaviors in standard behavioral assays conducted prior to placing the mice into the large group was predictive of initial network position and behavior but were not associated with final social network position. Finally, we determined that social network position is associated with variation in mRNA levels of two neural plasticity genes, DNMT1 and DNMT3a, in the hippocampus but not the mPOA. This work demonstrates the importance of understanding the role of social context and complex social dynamics in determining the relationship between individual differences in social behavior and brain gene expression. PMID:27540359

  11. Is arterial stiffness in HIV-infected individuals associated with HIV-related factors?

    International Nuclear Information System (INIS)

    We investigated the association between pulse wave velocity (PWV) and HIV infection, antiretroviral treatment-related characteristics, viral load, immune status, and metabolic changes in a cross-sectional study nested in a cohort of HIV/AIDS patients who have been followed for metabolic and cardiovascular changes since 2007. The study included patients recruited from the cohort (N = 261) and a comparison group (N = 82) of uninfected individuals, all enrolled from April to November 2009. Aortic stiffness was estimated using the carotid-femoral PWV (Complior-Artech, Paris, France). The groups were similar with respect to age, metabolic syndrome, diabetes mellitus, Framingham score, and use of antihypertensive and hypolipidemic medications. Hypertension was more frequent among the controls. Individuals with HIV had higher triglyceride, glucose and HDL cholesterol levels. Among individuals with HIV/AIDS, those with a nadir CD4+ T-cell count <200 cells/mm3 had a higher PWV (P = 0.01). There was no statistically significant difference when subjects were stratified by gender. Heart rate, age, male gender, and blood pressure were independently correlated with PWV. Nadir CD4+ T-cell count did not remain in the final model. There was no significance difference in PWV between HIV-infected individuals and uninfected controls. PWV was correlated with age, gender, and blood pressure across the entire population and among those infected with HIV. We recommend cohort studies to further explore the association between inflammation related to HIV infection and/or immune reconstitution and antiretroviral use and PWV

  12. Is arterial stiffness in HIV-infected individuals associated with HIV-related factors?

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, P. [Serviço de Doenças Infecciosas, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE (Brazil); Miranda-Filho, D.B. [Departamento de Medicina Clínica, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE (Brazil); Bandeira, F. [Serviço de Endocrinologia, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE (Brazil); Lacerda, H.R. [Departamento de Medicina Clínica, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE (Brazil); Departamento de Medicina Tropical, Faculdade de Medicina, Universidade Federal de Pernambuco, Recife, PE (Brazil); Chaves, H. [Departamento de Cardiologia, Faculdade de Medicina, Universidade Federal de Pernambuco, Recife, PE (Brazil); Albuquerque, M.F.P.M. [Centro de Pesquisa Aggeu Magalhães,FIOCRUZ, Recife, PE (Brazil); Montarroyos, U.R. [Departamento de Medicina Tropical, Faculdade de Medicina, Universidade Federal de Pernambuco, Recife, PE (Brazil); Ximenes, R.A.A. [Departamento de Medicina Clínica, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE (Brazil); Departamento de Medicina Tropical, Faculdade de Medicina, Universidade Federal de Pernambuco, Recife, PE (Brazil)

    2012-07-13

    We investigated the association between pulse wave velocity (PWV) and HIV infection, antiretroviral treatment-related characteristics, viral load, immune status, and metabolic changes in a cross-sectional study nested in a cohort of HIV/AIDS patients who have been followed for metabolic and cardiovascular changes since 2007. The study included patients recruited from the cohort (N = 261) and a comparison group (N = 82) of uninfected individuals, all enrolled from April to November 2009. Aortic stiffness was estimated using the carotid-femoral PWV (Complior-Artech, Paris, France). The groups were similar with respect to age, metabolic syndrome, diabetes mellitus, Framingham score, and use of antihypertensive and hypolipidemic medications. Hypertension was more frequent among the controls. Individuals with HIV had higher triglyceride, glucose and HDL cholesterol levels. Among individuals with HIV/AIDS, those with a nadir CD4{sup +} T-cell count <200 cells/mm{sup 3} had a higher PWV (P = 0.01). There was no statistically significant difference when subjects were stratified by gender. Heart rate, age, male gender, and blood pressure were independently correlated with PWV. Nadir CD4{sup +} T-cell count did not remain in the final model. There was no significance difference in PWV between HIV-infected individuals and uninfected controls. PWV was correlated with age, gender, and blood pressure across the entire population and among those infected with HIV. We recommend cohort studies to further explore the association between inflammation related to HIV infection and/or immune reconstitution and antiretroviral use and PWV.

  13. Is arterial stiffness in HIV-infected individuals associated with HIV-related factors?

    Directory of Open Access Journals (Sweden)

    P. Monteiro

    2012-09-01

    Full Text Available We investigated the association between pulse wave velocity (PWV and HIV infection, antiretroviral treatment-related characteristics, viral load, immune status, and metabolic changes in a cross-sectional study nested in a cohort of HIV/AIDS patients who have been followed for metabolic and cardiovascular changes since 2007. The study included patients recruited from the cohort (N = 261 and a comparison group (N = 82 of uninfected individuals, all enrolled from April to November 2009. Aortic stiffness was estimated using the carotid-femoral PWV (Complior-Artech, Paris, France. The groups were similar with respect to age, metabolic syndrome, diabetes mellitus, Framingham score, and use of antihypertensive and hypolipidemic medications. Hypertension was more frequent among the controls. Individuals with HIV had higher triglyceride, glucose and HDL cholesterol levels. Among individuals with HIV/AIDS, those with a nadir CD4+ T-cell count <200 cells/mm³ had a higher PWV (P = 0.01. There was no statistically significant difference when subjects were stratified by gender. Heart rate, age, male gender, and blood pressure were independently correlated with PWV. Nadir CD4+ T-cell count did not remain in the final model. There was no significance difference in PWV between HIV-infected individuals and uninfected controls. PWV was correlated with age, gender, and blood pressure across the entire population and among those infected with HIV. We recommend cohort studies to further explore the association between inflammation related to HIV infection and/or immune reconstitution and antiretroviral use and PWV.

  14. Expression patterns of microRNAs associated with CML phases and their disease related targets

    Directory of Open Access Journals (Sweden)

    Trněný Marek

    2011-04-01

    Full Text Available Abstract Background MicroRNAs are important regulators of transcription in hematopoiesis. Their expression deregulations were described in association with pathogenesis of some hematological malignancies. This study provides integrated microRNA expression profiling at different phases of chronic myeloid leukemia (CML with the aim to identify microRNAs associated with CML pathogenesis. The functions of in silico filtered targets are in this report annotated and discussed in relation to CML pathogenesis. Results Using microarrays we identified differential expression profiles of 49 miRNAs in CML patients at diagnosis, in hematological relapse, therapy failure, blast crisis and major molecular response. The expression deregulation of miR-150, miR-20a, miR-17, miR-19a, miR-103, miR-144, miR-155, miR-181a, miR-221 and miR-222 in CML was confirmed by real-time quantitative PCR. In silico analyses identified targeted genes of these miRNAs encoding proteins that are involved in cell cycle and growth regulation as well as several key signaling pathways such as of mitogen activated kinase-like protein (MAPK, epidermal growth factor receptor (EGFR, ERBB, transforming growth factor beta (TGFB1 and tumor protein p53 that are all related to CML. Decreased levels of miR-150 were detected in patients at diagnosis, in blast crisis and 67% of hematological relapses and showed significant negative correlation with miR-150 proved target MYB and with BCR-ABL transcript level. Conclusions This study uncovers microRNAs that are potentially involved in CML and the annotated functions of in silico filtered targets of selected miRNAs outline mechanisms whereby microRNAs may be involved in CML pathogenesis.

  15. Factors associated with recurrence of alcohol-related traffic violations in southern Brazil

    Directory of Open Access Journals (Sweden)

    Aurinez R. Schmitz

    2014-09-01

    Full Text Available Objective: To analyze variables associated with recurrence of blood alcohol content (BAC-related traffic violations among drivers in southern Brazil. Method: This cross-sectional study included 12,204 driving-under-the-influence (DUI offenders according to data provided by the Rio Grande do Sul state Transportation Department. Sociodemographic characteristics, license duration, license category, and psychological assessment results were analyzed. Drivers convicted of DUI more than once in 2009/2010 were considered recidivists. Variables were evaluated using descriptive statistical analysis and Poisson regression, adjusted by sex, age, and education level. Results: A total of 538 (4.41% drivers were considered recidivists. The following variables showed the strongest associations with recidivism: being aged 41-50 years (prevalence ratio [PR] = 3.41, being licensed for ≥ 12 years (PR = 1.86, being licensed for motorcycles, cars and trucks (PR = 1.36, having a license with psychological restrictions (PR = 1.33, and driving a truck or a similar vehicle at the moment of notification (PR = 1.08. Conclusions: In the age group with the highest risk for recurrence, drivers showed a higher probability of having a diagnosis of alcohol dependence and other psychiatric comorbidities that hinder the control of alcohol use. Psychological assessments seem to be important in predicting repeat offenses, especially when limited aptitudes are suspected, and should therefore be better investigated.

  16. [Genome-Wide Association Studies for life-style related diseases].

    Science.gov (United States)

    Maeda, Shiro

    2016-03-01

    After the completion of human genome project, development of single nucleotide polymorphism (SNP) typing technology and collation of information regarding linkage disequilibrium in the human genome have facilitated genome-wide association studies (GWAS) for investigating genes associated with disease susceptibility across the entire human genome. In case of type 2 diabetes, approximately 100 genetic loci have been identified and confirmed as susceptibility to the disease through GWAS in different ethnic groups, including Japanese, European, East Asian and South Asian populations. However, integration of these information accounts for less than 20% of the disease heritability, and thus most of the heritability of type 2 diabetes remain to be identified. Since the rationale of GWAS is based on the hypothesis that common variants contribute to the susceptibility to common diseases, common disease-common variant hypothesis, GWAS have selectively identified common susceptibility variants (allele frequency>=0.05) with lower effect size (odds ratiogenome sequencing to identify rare variants with greater effect size or integration of genetic and environmental information, will be required to elucidate a heritability of life-style related diseases completely. PMID:26923980

  17. Is Health-Related Quality of Life Associated with Upper and Lower Airway Inflammation in Asthmatics?

    Directory of Open Access Journals (Sweden)

    Nicola Scichilone

    2013-01-01

    Full Text Available Background. Allergic diseases impair health-related quality of life (HR-QoL. However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL. Methods. Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO test, collection of exhaled breath condensate (EBC, and nasal wash. Results. The Rhinasthma Global Summary score (GS was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation (% eosinophils: , ; ECP: , or bronchial inflammation (pH of the EBC: , ; bronchial NO: , ; alveolar NO: , . The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20 and uncontrolled (ACT < 20, the alveolar NO significantly correlated with GS in uncontrolled asthmatics (, . Conclusions. Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL.

  18. A functional CD86 polymorphism associated with asthma and related allergic disorders

    DEFF Research Database (Denmark)

    Corydon, Thomas Juhl; Haagerup, Annette; Jensen, Thomas Gryesten; Binderup, Helle Glud; Petersen, Mikkel Steen; Kaltoft, Keld; Vestbo, Jørgen; Kruse, Torben Arvid; Børglum, Anders Dupont

    2007-01-01

    BACKGROUND: Several studies have documented a substantial genetic component in the aetiology of allergic diseases and a number of atopy susceptibility loci have been suggested. One of these loci is 3q21, at which linkage to multiple atopy phenotypes has been reported. This region harbours the CD8......: The CD86 gene, and specifically the Ile179Val polymorphism, may be a novel aetiological factor in the development of asthma and related allergic disorders....... gene encoding the costimulatory B7.2 protein. The costimulatory system, consisting of receptor proteins, cytokines and associated factors, activates T cells and regulates the immune response upon allergen challenge. METHODS: We sequenced the CD86 gene in patients with atopy from 10 families that showed...... evidence of linkage to 3q21. Identified polymorphisms were analysed in a subsequent family-based association study of two independent Danish samples, respectively comprising 135 and 100 trios of children with atopy and their parents. Functional analysis of the costimulatory effect on cytokine production...

  19. Two-stage case-control association study of dopamine-related genes and migraine

    Directory of Open Access Journals (Sweden)

    Pardo Julio

    2009-09-01

    Full Text Available Abstract Background We previously reported risk haplotypes for two genes related with serotonin and dopamine metabolism: MAOA in migraine without aura and DDC in migraine with aura. Herein we investigate the contribution to migraine susceptibility of eight additional genes involved in dopamine neurotransmission. Methods We performed a two-stage case-control association study of 50 tag single nucleotide polymorphisms (SNPs, selected according to genetic coverage parameters. The first analysis consisted of 263 patients and 274 controls and the replication study was composed by 259 cases and 287 controls. All cases were diagnosed according to ICHD-II criteria, were Spanish Caucasian, and were sex-matched with control subjects. Results Single-marker analysis of the first population identified nominal associations of five genes with migraine. After applying a false discovery rate correction of 10%, the differences remained significant only for DRD2 (rs2283265 and TH (rs2070762. Multiple-marker analysis identified a five-marker T-C-G-C-G (rs12363125-rs2283265-rs2242592-rs1554929-rs2234689 risk haplotype in DRD2 and a two-marker A-C (rs6356-rs2070762 risk haplotype in TH that remained significant after correction by permutations. These results, however, were not replicated in the second independent cohort. Conclusion The present study does not support the involvement of the DRD1, DRD2, DRD3, DRD5, DBH, COMT, SLC6A3 and TH genes in the genetic predisposition to migraine in the Spanish population.

  20. On the relative energy associated with space-times of diagonal metrics

    Indian Academy of Sciences (India)

    Murat Korunur; Mustafa Salti; Ali havare

    2007-05-01

    In order to evaluate the energy distribution (due to matter and fields including gravitation) associated with a space-time model of generalized diagonal metric, we consider the Einstein, Bergmann–Thomson and Landau–Lifshitz energy and/or momentum definitions both in Einstein's theory of general relativity and the teleparallel gravity (the tetrad theory of gravitation). We find same energy distribution using Einstein and Bergmann–Thomson formulations, but we also find that the energy–momentum prescription of Landau–Lifshitz disagree in general with these definitions. We also give eight different well-known space-time models as examples, and considering these models and using our results, we calculate the energy distributions associated with them. Furthermore, we show that for the Bianchi Type-I models all the formulations give the same result. This result agrees with the previous works of Cooperstock–Israelit, Rosen, Johri et al, Banerjee–Sen, Xulu, Vargas and Saltı et al and supports the viewpoints of Albrow and Tryon.

  1. MHC class I-related molecule, MR1, and mucosal-associated invariant T cells.

    Science.gov (United States)

    Franciszkiewicz, Katarzyna; Salou, Marion; Legoux, Francois; Zhou, Qian; Cui, Yue; Bessoles, Stéphanie; Lantz, Olivier

    2016-07-01

    The MHC-related 1, MR1, molecule presents a new class of microbial antigens (derivatives of the riboflavin [Vitamin B2] biosynthesis pathway) to mucosal-associated invariant T (MAIT) cells. This raises many questions regarding antigens loading and intracellular trafficking of the MR1/ligand complexes. The MR1/MAIT field is also important because MAIT cells are very abundant in humans and their frequency is modified in many infectious and non-infectious diseases. Both MR1 and the invariant TCRα chain expressed by MAIT cells are strikingly conserved among species, indicating important functions. Riboflavin is synthesized by plants and most bacteria and yeasts but not animals, and its precursor derivatives activating MAIT cells are short-lived unless bound to MR1. The recognition of MR1 loaded with these compounds is therefore an exquisite manner to detect invasive bacteria. Herein, we provide an historical perspective of the field before describing the main characteristics of MR1, its ligands, and the few available data regarding its cellular biology. We then summarize the current knowledge of MAIT cell differentiation and discuss the definition of MAIT cells in comparison to related subsets. Finally, we describe the phenotype and effector activities of MAIT cells. PMID:27319347

  2. The new ventures’ international result. A relational view associated to network market orientation

    Directory of Open Access Journals (Sweden)

    Diego Monferrer Tirado

    2016-04-01

    Full Text Available This paper delves into the study of the factors that influence the international competitive position of international new ventures, and consequently, their international performance. By combining international entrepreneurship and marketing disciplines, this work attempts to emphasise the importance of relational knowledge by the influence of network market orientation on the international results obtained by these firms through the mediating effect of competitive advantages. The approach was used to test our hypotheses. The results obtained, using structural equations models and multi-sample analysis, confirm that network market orientation is a determining factor for new ventures to achieve superior international results. This influence is observed indirectly with the mediating effect on the differentiation- and cost-based competitive advantages developed by these firms. This study extends previous international entrepreneurship research, including insights from the marketing discipline on antecedents of international new ventures’ competitiveness and success in foreign markets. In addition, the results obtained encourage entrepreneurs in the international context to consider the explicit value of other factors different from experiential knowledge, which the company acquired gradually with increasing its experience in the foreign market, to realize the potential value of relational knowledge associated to network market orientation as an antecedent for the achievement of competitive advantages in the international market.

  3. ASSOCIATION BETWEEN SARCOPENIA-RELATED PHENOTYPES AND AEROBIC CAPACITY INDEXES OF OLDER WOMEN

    Directory of Open Access Journals (Sweden)

    Lídia Mara Aguiar Bezerra

    2009-09-01

    Full Text Available The purpose of the present study was to examine the association between fat-free mass (FFM, quadriceps strength and sarcopenia with aerobic fitness indexes of elderly women. A total of 189 volunteers (66.7 ± 5.46 years underwent aerobic capacity measurement through a symptom-limited cardiopulmonary exercise test to determine their individual ventilatory thresholds (VT and peak oxygen uptake (VO2 peak. Quadriceps muscle strength was assessed using an isokinetic dynamometer. Also, dual energy X-ray absorptiometry was used to assess FFM and cutoff values were used to classify subjects as sarcopenic or nonsarcopenic. Correlations, student t-test and analysis of variance were used to examine the data. Both FFM and quadriceps strength variables were positively and significantly correlated with the measured aerobic capacity indexes. These results were observed for peak exercise as well as for ventilatory thresholds. Individuals classified as sarcopenic presented significantly lower muscle strength and (VO2 peak when compared to nonsarcopenic. It can be concluded that FFM and quadriceps strength are significantly related to aerobic capacity indexes in older women, and that besides presenting lower quadriceps strength, women classified as sarcopenic have lower peak oxygen consumption. Taken together, the present results indicate that both FFM and strength play a role in the age-related decline of aerobic capacity

  4. Mediterranean Dietary Pattern Adherence: Associations with Prediabetes, Metabolic Syndrome, and Related Microinflammation

    Science.gov (United States)

    Cipriani, Elisa; Liguori, Maria Livia; Marigliano, Benedetta; Saliola, Mirella; Ettorre, Evaristo; Andreozzi, Paola

    2013-01-01

    Abstract Background The adherence to the Mediterranean Diet (Med Diet) seems to reduce the incidence of metabolic syndrome. The present study aimed to explore whether the adherence to the overall Med Diet pattern and to specific Med Diet items is associated with the presence of metabolic syndrome, impaired fasting glucose (IFG), insulin resistance (IR), and microinflammation in subjects free of diabetes and cardiovascular diseases. Measurements Each patient underwent clinical assessment. Adherence to the Med Diet was measured by a previously validated 14-item questionnaire. Metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria; IR was defined by homeostasis model assessment of insulin resistance (HOMA-IR); inflammation was assessed through a high-sensitivity C-reactive protein (hsCRP) assay. Results A total of 120 subjects (64.2% women, mean age 59.8±10.2 years) were enrolled at this study. Subjects with lower Med Diet pattern adherence exhibited higher occurrence of metabolic syndrome and all its components and higher HOMA-IR and hsCRP values (P for all <0.0001). Subjects with metabolic syndrome were less likely to consume olive oil (P=0.002) and vegetables (P=0.023). By multivariable analyses, the overall Med Diet score was found to be strongly and inversely associated with the presence of metabolic syndrome [B=−0.066; 95% confidence interval (CI) −0.105 to −0.028; P=0.001], IFG (B=−0.076; 95% CI −0.114 to −0.038; p<0.0001), high HOMA-IR (B=−0.071; 95% CI −0.108 to −0.034; P<0.0001) and high hsCRP (B=−0.082; 95% CI −0.125 to −0.045; P<0.0001). None of specific Med Diet items independently predicted metabolic syndrome, IFG, and high HOMA-IR. Instead, the consumption of white meat over red meat (B=−0.324; 95% CI −0.467 to −0.178; P<0.0001) was found to be inversely associated with increased hsCRP. Conclusions The inverse associations between adherence to Med Diet

  5. A circulating microrna profile is associated with late-stage neovascular age-related macular degeneration.

    Directory of Open Access Journals (Sweden)

    Felix Grassmann

    Full Text Available Age-related macular degeneration (AMD is the leading cause of severe vision impairment in Western populations over 55 years. A growing number of gene variants have been identified which are strongly associated with an altered risk to develop AMD. Nevertheless, gene-based biomarkers which could be dysregulated at defined stages of AMD may point toward key processes in disease mechanism and thus may support efforts to design novel treatment regimens for this blinding disorder. Circulating microRNAs (cmiRNAs which are carried by nanosized exosomes or microvesicles in blood plasma or serum, have been recognized as valuable indicators for various age-related diseases. We therefore aimed to elucidate the role of cmiRNAs in AMD by genome-wide miRNA expression profiling and replication analyses in 147 controls and 129 neovascular AMD patients. We identified three microRNAs differentially secreted in neovascular (NV AMD (hsa-mir-301-3p, pcorrected = 5.6*10-5, hsa-mir-361-5p, pcorrected = 8.0*10-4 and hsa-mir-424-5p, pcorrected = 9.6*10-3. A combined profile of the three miRNAs revealed an area under the curve (AUC value of 0.727 and was highly associated with NV AMD (p = 1.2*10-8. To evaluate subtype-specificity, an additional 59 AMD cases with pure unilateral or bilateral geographic atrophy (GA were analyzed for microRNAs hsa-mir-301-3p, hsa-mir-361-5p, and hsa-mir-424-5p. While we found no significant differences between GA AMD and controls neither individually nor for a combined microRNAs profile, hsa-mir-424-5p levels remained significantly higher in GA AMD when compared to NV (pcorrected<0.005. Pathway enrichment analysis on genes predicted to be regulated by microRNAs hsa-mir-301-3p, hsa-mir-361-5p, and hsa-mir-424-5p, suggests canonical TGFβ, mTOR and related pathways to be involved in NV AMD. In addition, knockdown of hsa-mir-361-5p resulted in increased neovascularization in an in vitro angiogenesis assay.

  6. Environmental pollutions associated to conflicts in Iraq and related health problems.

    Science.gov (United States)

    Al-Shammari, Ahmed Majeed

    2016-06-01

    Several wars and a 13-year embargo as well as several years of civil war with the recent war on terrorism have cumulatively damaged Iraq's land, air, water, and health infrastructure. The sand particles in Iraq contain toxic substances, which dates back to the pollution caused by military actions that disassemble the desert sands and turn it into light dust. This dust reaches cities as dust storms that effect most Iraqi cities. The presence of depleted uranium (DU) in the Iraqi food chain is documented by measuring the uranium in animals organs in different Iraqi cities with the highest concentration in the south of Iraq. One of the major sites of pollution in Iraq is the Al-twaitha nuclear research site. The nuclear research reactors were destroyed in the 1991 Gulf War. Barrels containing radioactive materials and sources were stolen from the site in the 2003 war. This resulted in considerable radioactive pollution at the site and in its surrounding areas. Soil sample have been found to be contaminated by Cs-137and Co-60. Cancer and birth defects are most associated with the environmental pollution caused by the conflicts. All studies related to this by Iraqi researchers are discussed in this review. From studying the Iraqi scientific publications, we can conclude that Basrah, Baghdad, Faluja, Mosul and Thi-Qar are the most effected cities in Iraq. This review concludes that the presence of a heavily contaminated environment with war related pollutants in most of the Iraqi cities needs much attention and huge effort to reduce the related health problems. PMID:26512425

  7. Plantar pressure measurements and running-related injury: A systematic review of methods and possible associations.

    Science.gov (United States)

    Mann, Robert; Malisoux, Laurent; Urhausen, Axel; Meijer, Kenneth; Theisen, Daniel

    2016-06-01

    Pressure-sensitive measuring devices have been identified as appropriate tools for measuring an array of parameters during running. It is unclear which biomechanical characteristics relate to running-related injury (RRI) and which data-processing techniques are most promising to detect this relationship. This systematic review aims to identify pertinent methodologies and characteristics measured using plantar pressure devices, and to summarise their associations with RRI. PubMed, Embase, CINAHL, ScienceDirect and Scopus were searched up until March 2015. Retrospective and prospective, biomechanical studies on running using any kind of pressure-sensitive device with RRI as an outcome were included. All studies involving regular or recreational runners were considered. The study quality was assessed and the measured parameters were summarised. One low quality, two moderate quality and five high quality studies were included. Five different subdivisions of plantar area were identified, as well as five instants and four phases of measurement during foot-ground contact. Overall many parameters were collated and subdivided as plantar pressure and force, plantar pressure and force location, contact area, timing and stride parameters. Differences between the injured and control group were found for mediolateral and anteroposterior displacement of force, contact area, velocity of force displacement, relative force-time integral, mediolateral force ratio, time to peak force and inter-stride correlative patterns. However, no consistent results were found between studies and no biomechanical risk patterns were apparent. Additionally, conflicting findings were reported for peak force in three studies. Based on these observations, we provide suggestions for improved methodology measurement of pertinent parameters for future studies. PMID:27264395

  8. Triangulation of sprites, associated halos and their possible relation to causative lightning and micrometeors

    Science.gov (United States)

    Wescott, E. M.; Stenbaek-Nielsen, H. C.; Sentman, D. D.; Heavner, M. J.; Moudry, D. R.; Sabbas, F. T. São

    2001-06-01

    Sprite halos were recently identified as an impulsive but spatially diffuse phenomenon that sometimes occurs just prior to, but distinct from, sprites. The lack of discernible spatial structure and the temporal development sequence in halos differs markedly from the highly structured bodies and tendrils and the complex development sequences of sprites. However, both phenomena are thought to result from an electric field due to charge moment changes usually associated with large positive cloud-to-ground (CG) lightning but also following negative CG flashes. Three-dimensional triangulations of sprites and sprite halos were made between stations in South Dakota and Wyoming in August 1999 during the NASA Sprites99 balloon campaign. Halos were found to have a Gaussian 1/e diameter of ~66 km and 1/e thickness of ~4 km. Comparison with the location of the underlying lightning strokes, as recorded by the National Lightning Detection Network (NLDN), confirms that the horizontal position of sprites may be laterally offset by as much as 50 km from the underlying parent lightning discharge, as has been previously reported. The point of maximum apparent brightness for sprite halos occurs at an altitude of ~78 km, similar to that of sprites. However, unlike sprites, this point tends to be centered directly above the underlying parent lightning discharge, 4.6+/-2.7km mean distance from the center of the halo to the NLDN location. This difference in spatial location relative to the underlying lightning suggests that the electrical breakdown associated with discrete sprites may require a random ionizing event such as a micrometeor. In contrast, sprite halos do not appear to require such a random component.

  9. Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes.

    Science.gov (United States)

    Immervoll, T; Loesgen, S; Dütsch, G; Gohlke, H; Herbon, N; Klugbauer, S; Dempfle, A; Bickeböller, H; Becker-Follmann, J; Rüschendorf, F; Saar, K; Reis, A; Wichmann, H E; Wjst, M

    2001-10-01

    Several genome-wide screens for asthma and related phenotypes have been published to date but data on fine-mapping are scarce. For higher resolution we performed a fine-mapping study with 2 cM average spacing in often discussed asthma candidate regions (2p, 5q, 6p, 7p, 9q, 11p, and 12q) to narrow down the regions of interest. All participants of a Caucasian family study (97 families with at least two affected sib pairs) were genotyped for 49 supplementary polymorphic dinucleotide markers. Our results indicate increased evidence for linkage on chromosome 6p, 9q, and 12q. These candidate regions were further analyzed with SNP polymorphisms in the endothelin 1 (EDN1), lymphotoxin alpha (LTA), and neuronal nitric oxide synthase (NOS1) genes. In addition, IL4 -590C>T and IL10 -592C>A, localized on chromosomes 5q and 1q, respectively, have been analyzed for SNP association. Of the six SNPs tested, four revealed weak association with the examined phenotypes. These are the IL10 -592C>A SNP in the interleukin 10 gene (p=0.036 for eosinophil cell counts), the 4124T>C SNP in EDN1 (p=0.044 for asthma), the 3391C>T SNP in NOS1 with eosinophil cell counts (p=0.0086), and the 5266C>T polymorphism, also in the NOS1 gene, for high IgE levels (p=0.022). In summary, fine mapping data enable us to confine asthma candidate regions, while variants of EDN1 and NOS1, or nearby genes, may play an important role in this context. PMID:11668616

  10. Self-reported and measured stress related responses associated with exposure to wind turbine noise.

    Science.gov (United States)

    Michaud, David S; Feder, Katya; Keith, Stephen E; Voicescu, Sonia A; Marro, Leonora; Than, John; Guay, Mireille; Denning, Allison; Bower, Tara; Villeneuve, Paul J; Russell, Evan; Koren, Gideon; van den Berg, Frits

    2016-03-01

    The current study was the first to assess stress reactions associated with wind turbine noise (WTN) exposure using self-reported and objective measures. Randomly selected participants, aged 18-79 yr (606 males; 632 females), living between 0.25 and 11.22 km from wind turbines, were exposed to outdoor calculated WTN levels up to 46 dBA (response rate 78.9%). Multiple regression modeling left the great majority (77%-89%) of the variance in perceived stress scale (PSS) scores, hair cortisol concentrations, resting blood pressure, and heart rate unaccounted for, and WTN exposure had no apparent influence on any of these endpoints. PSS scores were positively, but weakly, related to cortisol concentrations and resting heart rate (Pearson r = 0.13 and r = 0.08, respectively). Across WTN categories, modeled mean PSS scores ranged from 13.15 to 13.84 (p = 0.8614). Modeled geometric means for hair cortisol concentrations, resting mean systolic, diastolic blood pressure, and heart rate were 150.54-191.12 ng/g (p = 0.5416), 113.38-116.82 mmHg (p = 0.4990), 67.98-70.34 mmHg (p = 0.5006), and 68.24-70.71 bpm (p = 0.5223), respectively. Irrespective of WTN levels, diastolic blood pressure appeared to be slightly (2.90 mmHg 95% CI: 0.75,5.05) higher among participants highly annoyed by blinking lights on turbines (p = 0.0081). Collectively, the findings do not support an association between exposure to WTN up to 46 dBA and elevated self-reported and objectively defined measures of stress. PMID:27036285

  11. Von Hippel-Lindau disease associated with myasthenia gravis not related to thymoma

    Directory of Open Access Journals (Sweden)

    Paolo Pozzato

    2013-04-01

    Full Text Available BACKGROUND Von Hippel-Lindau disease (VHL is a rare autosomal dominant inherited disorder characterized by an increased risk of tumours in a number of locations (eyes, brain, adrenal gland, pancreas, liver, kidneys, or other areas of the body. It is caused by germline mutation in the VHL gene. The VHL gene is a tumour suppressor gene that has been identified on the short arm of chromosome 3. CASE REPORT We report a case of a 60 year-old female with the clinical diagnosis of VHL type 1 (cerebellar haemangioblastoma, pancreatic cysts with subsequent steatorrhoea, and bilateral renal carcinoma who developed weakness and fatigability of skeletal muscles, left lid ptosis, snarling expression and nasal timbre speech. Acetylcholine receptor antibodies were negative in serum, while the electrodiagnostic test demonstrated an alteration of neuromuscolar junction which was consistent with the diagnosis of myasthenia gravis. Contrast-enhanced TC scan of the anterior mediastinum was performed, which excluded thymus enlargement. VHL gene evaluation in this patient identified a new mutation (c279delC9 and polymorphism c291C>G. At present the patient still suffers from ataxia and dysmetria due to cerebellar involvement in VHL, while fatigue and lid ptosis improved after the treatment with oral pyridostigmine 60 mg tid. DISCUSSION AND CONCLUSIONS To our knowledge this is the first report of a case of VHL associated with myasthenia gravis without thymoma. A case of VHL associated with a form of myasthenia gravis related to thymoma has been recently reported. In our case the absence of acetylcholine receptor antibodies may suggest a genetic origin also for the myasthenia gravis.

  12. HIV-associated lymphoma: histopathology and association with Epstein-Barr virus genome related to clinical, immunological and prognostic features

    DEFF Research Database (Denmark)

    Pedersen, C; Gerstoft, J; Lundgren, Jens Dilling;

    1991-01-01

    All 51 cases of HIV-related malignant lymphoma in Denmark diagnosed from 1983 to 1989 were reviewed. There were 12 Burkitt-type lymphomas, 30 immunoblast-rich lymphomas and 9 other lymphomas. Patients with immunoblast-rich lymphomas had significantly lower CD4 cell counts (median 60 vs. 188 x 10(...

  13. Fish oil diet associated with acute reperfusion related haemorrhage, and with reduced stroke-related sickness behaviours and motor impairment

    Directory of Open Access Journals (Sweden)

    DavidWHowells

    2014-02-01

    Full Text Available Ischemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids (PUFA. However, the potential protective effects of PUFA supplementation on affective behaviours after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioural effects of PUFA supplementation over a six-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute haemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined six weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviours, acute motor impairment and longer-term locomotor hyperactivity and depression/anxiety-like behaviour.

  14. Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

    DEFF Research Database (Denmark)

    Sparsø, Thomas; Hussain, Meena Shaheen; Borch-Johnsen, Knut; Jørgensen, Torben; Madsbad, Sten; Hansen, Torben; Pedersen, Oluf; Andersen, Gitte

    2007-01-01

    Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 po...... polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits....

  15. Associations between Sadness and Anger Regulation Coping, Emotional Expression, and Physical and Relational Aggression among Urban Adolescents

    OpenAIRE

    Sullivan, Terri N.; Helms, Sarah W.; Kliewer, Wendy; Goodman, Kimberly L.

    2010-01-01

    This study examined associations between self reports of sadness and anger regulation coping, reluctance to express emotion, and physical and relational aggression among two cohorts of predominantly African-American fifth (N = 191; 93 boys and 98 girls) and eighth (N = 167; 73 boys and 94 girls) graders. Multiple regression analyses indicated unique associations between relational aggression and expressive reluctance and sadness regulation coping. In contrast, physical aggression, but not rel...

  16. Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

    OpenAIRE

    Marvelle, Amanda F.; Lange, Leslie A.; Qin, Li; Adair, Linda S; Mohlke, Karen L

    2008-01-01

    OBJECTIVE—The underlying genetic component of obesity-related traits is not well understood, and there is limited evidence to support genetic association shared across multiple studies, populations, and environmental contexts. The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort. RESEARCH DESIGN AND METHODS—We selected and genotyped 19...

  17. FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness

    DEFF Research Database (Denmark)

    Kring, Sofia I I; Holst, Claus; Zimmermann, Esther; Jess, Tine; Berentzen, Tina; Toubro, Søren; Hansen, Torben; Astrup, Arne; Pedersen, Oluf; Sørensen, Thorkild I A

    2008-01-01

    A common single nucleotide polymorphism (SNP) of FTO (rs9939609, T/A) is associated with total body fatness. We investigated the association of this SNP with abdominal and peripheral fatness and obesity-related metabolic traits in middle-aged men through a broad range of fatness present already in...

  18. An Analysis of National Surveys: Associate Degree Programs in Manufacturing Engineering and Related Programs. A Preliminary Report.

    Science.gov (United States)

    Mathias, Elizabeth A.

    In 1993, a study was conducted to investigate the responses of associate degree programs in manufacturing and related technical programs to current technical education initiatives. The study focused on the relationships of associate degree programs to secondary and postsecondary education and industry, curricular trends, familiarity with the…

  19. Related factors of thyroid-associated ophthalmopathy in patents with Graves' disease after 131I treatment

    International Nuclear Information System (INIS)

    Objective: To analysis the related factors of thyroid-associated ophthalmopathy(TAO) in patients with Graves' disease after 131I treatment. Methods: Five hundred and sixty two patients with Graves' disease were followed up after 131I treatment, included 243 cases with TAO and 319 cases without TAO. Logistic multivariate regression analysis was used to analyse the data of the improvement of the TAO, stability and progression. Results: Of the patients without TAO, 10 new cases of TAO were diagnosed (3.13%). Of the patients with TAO, 134 (55.14%) had experienced improvement, 99 (40.74%) cases with stable disease and 10 (4.12%) cases with progressed disease. The progression rate were no difference between the part of patients with and without TAO (χ2=0.576, P>0.05), and were difference between simple and invasive prominent eyes groups (χ2=11.893, P2=10.621, P131I therapy had no obviously influence between Graves' disease with and without TAO, and early controling the risk factors and treatment with glucocorticoid could prevent aggravation of TAO. (authors)

  20. Association study of functional genetic variants of innate immunity related genes in celiac disease

    Directory of Open Access Journals (Sweden)

    Martín J

    2005-08-01

    Full Text Available Abstract Background Recent evidence suggest that the innate immune system is implicated in the early events of celiac disease (CD pathogenesis. In this work for the first time we have assessed the relevance of different proinflammatory mediators typically related to innate immunity in CD predisposition. Methods We performed a familial study in which 105 celiac families characterized by the presence of an affected child with CD were genotyped for functional polymorphisms located at regulatory regions of IL-1α, IL-1β, IL-1RN, IL-18, RANTES and MCP-1 genes. Familial data was analysed with a transmission disequilibrium test (TDT that revealed no statistically significant differences in the transmission pattern of the different genetic markers considered. Results The TDT analysis for IL-1α, IL-1β, IL-1RN, IL-18, and MCP-1 genes genetic variants did not reveal biased transmission to the affected offspring. Only a borderline association of RANTES promoter genetic variants with CD predisposition was observed. Conclusion Our results suggest that the analysed polymorphisms of IL-1α, IL-1β, IL-1RN, IL-18, RANTES and MCP-1 genes do not seem to play a major role in CD genetic predisposition in our population.

  1. An Analysis of Thermally-Related Surface Rainfall Budgets Associated with Convective and Stratiform Rainfall

    Institute of Scientific and Technical Information of China (English)

    ZHOU Yushu; Xiaofan LI

    2011-01-01

    Both water vapor and heat processes play key roles in producing surface rainfall.While the water vapor effects of sea surface temperature and cloud radiative and microphysical processes on surface rainfall have been investigated in previous studies,the thermal effects on rainfall are analyzed in this study using a series of two-dimensional equilibrium cloud-resolving model experiments forced by zonally-uniform,constant,large-scale zonal wind and zero large-scale vertical velocity.The analysis of thermally-related surface rainfall budget reveals that the model domain mean surface rain rate is primarily associated with the mean infrared cooling rate.Convective rainfall and transport of hydrometeor concentration from convective regions to raining stratiform regions corresponds to the heat divergence over convective regions,whereas stratiform rainfall corresponds to the transport of hydrometeor concentration from convective regions and heat divergence over raining stratiform regions.The heat divergence over convective regions is mainly balanced by the heat convergence over rainfall-free regions,which is,in turn,offset by the radiative cooling over rainfall-free regions.The sensitivity experiments of rainfall to the effects of sea surface temperature and cloud radiative and microphysical processes show that the sea surface temperature and cloud processes affect convective rainfall through the changes in infrared cooling rate over rainfall-free regions and transport rate of heat from convective regions to rainfall-free regions.

  2. Harmonisation of standards related to limiting chemical risk associated with work processes.

    Science.gov (United States)

    Bostan, Ionel

    2013-01-01

    The presented paper tackles the issue of risk factors specific to work processes that involve the presence of chemicals. The reason that supports the present approach is the fact that the risks most likely to affect health in the workplace have been lately associated with the exposure of workers engaged in industrial activities to aggressive chemical agents. In order to tackle this problem, we shall resort to the normative regulations that have been adjusted upon Romania's inclusion in the European Union. The harmonization and alignment of the national standards--applied to the work systems that make use of various chemical substances likely to affect the health of the human resource--to the European guidelines and regulations has brought about a significant improvement in workplace security practices. Consequently, the arguments and demonstrations in the presented study are based on elements of the European acquis and the Romanian regulations which are all related to the chemical risk factors generated by harmful chemicals, or the potentially accident-prone properties of the substances used in work processes. PMID:24069850

  3. Association between plasma testosterone and work-related neck and shoulder disorders among female workers

    DEFF Research Database (Denmark)

    Kaergaard, A; Hansen, Åse Marie; Rasmussen, K;

    2000-01-01

    The aims were to study the association between anabolic hormone testosterone in plasma and the presence of musculoskeletal disorders among female workers and to study the association between changes in testosterone and changes in musculoskeletal complaints.......The aims were to study the association between anabolic hormone testosterone in plasma and the presence of musculoskeletal disorders among female workers and to study the association between changes in testosterone and changes in musculoskeletal complaints....

  4. Revealing Significant Relations between Chemical/Biological Features and Activity: Associative Classification Mining for Drug Discovery

    Science.gov (United States)

    Yu, Pulan

    2012-01-01

    Classification, clustering and association mining are major tasks of data mining and have been widely used for knowledge discovery. Associative classification mining, the combination of both association rule mining and classification, has emerged as an indispensable way to support decision making and scientific research. In particular, it offers a…

  5. Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities

    OpenAIRE

    Sinden, Nicola J.; Stockley, Robert A

    2010-01-01

    Chronic obstructive pulmonary disease (COPD) is associated with a pulmonary inflammatory response to inhaled substances, and individuals with COPD often have raised levels of several circulating inflammatory markers indicating the presence of systemic inflammation. Recently, there has been increasing interest in comorbidities associated with COPD such as skeletal muscle dysfunction, cardiovascular disease, osteoporosis, diabetes and lung cancer. These conditions are associated with a similar ...

  6. PTSD Symptom Severities, Interpersonal Traumas, and Benzodiazepines Are Associated with Substance-Related Problems in Trauma Patients

    Directory of Open Access Journals (Sweden)

    Jeffrey Guina

    2016-08-01

    Full Text Available Background: Trauma is commonly associated with substance-related problems, yet associations between specific substances and specific posttraumatic stress disorder symptoms (PTSSs are understudied. We hypothesized that substance-related problems are associated with PTSS severities, interpersonal traumas, and benzodiazepine prescriptions. Methods: Using a cross-sectional survey methodology in a consecutive sample of adult outpatients with trauma histories (n = 472, we used logistic regression to examine substance-related problems in general (primary, confirmatory analysis, as well as alcohol, tobacco, and illicit drug problems specifically (secondary, exploratory analyses in relation to demographics, trauma type, PTSSs, and benzodiazepine prescriptions. Results: After adjusting for multiple testing, several factors were significantly associated with substance-related problems, particularly benzodiazepines (AOR = 2.78; 1.99 for alcohol, 2.42 for tobacco, 8.02 for illicit drugs, DSM-5 PTSD diagnosis (AOR = 1.92; 2.38 for alcohol, 2.00 for tobacco, 2.14 for illicit drugs, most PTSSs (especially negative beliefs, recklessness, and avoidance, and interpersonal traumas (e.g., assaults and child abuse. Conclusion: In this clinical sample, there were consistent and strong associations between several trauma-related variables and substance-related problems, consistent with our hypotheses. We discuss possible explanations and implications of these findings, which we hope will stimulate further research, and improve screening and treatment.

  7. PTSD Symptom Severities, Interpersonal Traumas, and Benzodiazepines Are Associated with Substance-Related Problems in Trauma Patients

    Science.gov (United States)

    Guina, Jeffrey; Nahhas, Ramzi W.; Goldberg, Adam J.; Farnsworth, Seth

    2016-01-01

    Background: Trauma is commonly associated with substance-related problems, yet associations between specific substances and specific posttraumatic stress disorder symptoms (PTSSs) are understudied. We hypothesized that substance-related problems are associated with PTSS severities, interpersonal traumas, and benzodiazepine prescriptions. Methods: Using a cross-sectional survey methodology in a consecutive sample of adult outpatients with trauma histories (n = 472), we used logistic regression to examine substance-related problems in general (primary, confirmatory analysis), as well as alcohol, tobacco, and illicit drug problems specifically (secondary, exploratory analyses) in relation to demographics, trauma type, PTSSs, and benzodiazepine prescriptions. Results: After adjusting for multiple testing, several factors were significantly associated with substance-related problems, particularly benzodiazepines (AOR = 2.78; 1.99 for alcohol, 2.42 for tobacco, 8.02 for illicit drugs), DSM-5 PTSD diagnosis (AOR = 1.92; 2.38 for alcohol, 2.00 for tobacco, 2.14 for illicit drugs), most PTSSs (especially negative beliefs, recklessness, and avoidance), and interpersonal traumas (e.g., assaults and child abuse). Conclusion: In this clinical sample, there were consistent and strong associations between several trauma-related variables and substance-related problems, consistent with our hypotheses. We discuss possible explanations and implications of these findings, which we hope will stimulate further research, and improve screening and treatment. PMID:27517964

  8. Cognitive function in relation with bone mass and nutrition: cross-sectional association in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Brownbill Rhonda A

    2004-05-01

    Full Text Available Abstract Background It has been suggested that bone loss and cognitive decline are co-occurring conditions, possibly due to their relationship with estrogen. Cognitive decline has been associated with various nutritional deficiencies as well. The purpose of this study was to determine if cognitive function is related to bone mineral density of various skeletal sites as well as to various dietary components. Methods Cross-sectional study with 97 healthy, Caucasian, postmenopausal women (59.4–85.0 years enrolled in a larger longitudinal study, investigating the effects of sodium on bone mass. The subjects were divided into two groups based on cognition scores. Group 1 represented lower and Group 2 higher scores on cognitive function. Bone mineral density from the whole body, lumbar spine, femur and forearm were measured with the Lunar DPX-MD instrument. Anthropometry was measured by standard methods. Cognition was assessed using the Mini Mental State Examination. Cumulative (over 2 years dietary intake from 3-day records was analyzed by Food Processor® (ESHA Research, Salem, OR and cumulative physical activity was assessed using Allied Dunbar National Fitness Survey for older adults. Results Subjects' cognition scores ranged from 22–30 (normal, 27–30, indicating all subjects had either mild or no cognitive impairment. Multiple Analysis of Covariance adjusted for age, height, weight, physical activity, alcohol, calcium, sodium and energy intake, showed a statistically significant association between cognition and bone mineral density of all measurable sites (η2 = 0.21, P 2 = 0.07, P = 0.050. Group 2 did have a significantly higher potassium intake (P = 0.023. In multiple regression, saturated fat had a significant negative relationship with cognitive function. Conclusions It appears mild degree of cognitive impairment may be a marker for lower bone mineral density as well as for a diet lower in carbohydrate and potassium intake, and higher

  9. Volcanoes and associated topics in relation to nuclear power plant siting

    International Nuclear Information System (INIS)

    The main purpose of this report is to provide draft guidance on the criteria and methods for the evaluation of a site for a nuclear power plant with respect to the potential effects of volcanic activity which may jeopardize its safety and to elicit feedback from Member States. Different types of phenomena associated with volcanism are discussed in terms of their influence on site acceptability and on derivation of design basis parameters. This report was developed for application to new nuclear power plant sites. It does not address the issue of the re-evaluation of existing nuclear power sites to the potential effects of volcanic activity, although it contains general information and criteria useful for this purpose. The guidelines and procedures discussed in this report can appropriately be used as the basis for the safe siting and design of nuclear power plants in different volcanic environments. In this report, the description of the phenomena associated with volcanism and the collection of required data and information are separated from the criteria for hazard assessment. Thus Section 2 gives the non-specialist a general description of the different types of volcanic phenomena and Section 4 provides indication on the acquisition of the database. Section 3 outlines the general requirements to be fulfilled during site selection and evaluation. Sections 5, 6 and 7 provide guidance to perform the hazard assessment and to derive the design basis parameters. Finally, Section 8 deals with monitoring systems. As general information for the non-specialist, Annex I provides the major divisions of geological time. With the same spirit, and recognizing that a complete consensus has not been reached in the scientific community on the use and meaning of some terms, a glossary of volcanological definitions is given in Annex II, applicable only to the use of this report. Finally, Annex III provides an example of a classification of volcanoes that may be used for capability

  10. Factors Associated with General and Sexual Alcohol-Related Consequences: An Examination of College Students Studying Abroad

    Science.gov (United States)

    Hummer, Justin F.; Pedersen, Eric R.; Mirza, Tehniat; LaBrie, Joseph W.

    2010-01-01

    This study contributes to the scarce research on U.S. college students studying abroad by documenting general and sexual negative alcohol-related risks and factors associated with such risk. The manner of drinking (quantity vs. frequency), pre-departure expectations surrounding alcohol use while abroad, culture-related social anxiety, and…

  11. Affective associations and cognitive beliefs relate to individuals' decisions to perform testicular or breast self-exams.

    Science.gov (United States)

    Brown-Kramer, Carolyn R; Kiviniemi, Marc T

    2015-08-01

    Affective associations with behavioral practices play an important role in individuals' uptake of a variety of health behaviors. Most work has looked at individual behavioral practices with a direct impact on health; because screening behaviors are conceptually distinct from such behaviors, it is important to examine the interplay of affect and cognition in screening decision making. The current research explored affective and cognitive predictors of testicular and breast self-examination behavior. Young adult participants (N = 184) reported cognitive beliefs and affective associations with testicular self-exam behavior (male participants) and breast self-exam behavior (female participants) and reported their own current screening behavior. In univariable models, affective associations were related to screening behavior for both testicular self-exams and breast self-exams. When examining affective associations and cognitive beliefs as simultaneous predictors, affective associations (but not cognitive beliefs) predicted testicular self-exams, and neither affective associations nor cognitive beliefs were uniquely related to breast self-exams. Moreover, for testicular self-exams, affective associations mediated the relation between cognitive beliefs and screening behavior; no mediation was present for breast self-exam behavior. These findings suggest three potential outcomes: first, that greater consideration of affective associations in testicular self-exam screening decisions may be warranted; second, that breast and testicular self-exams may have different antecedents; and third, that incorporation of affective factors in intervention design might have merit for increasing engagement in some cancer screening behaviors. PMID:25851610

  12. Exploring College Students' Use of General and Alcohol-Related Social Media and Their Associations with Alcohol-Related Behaviors

    Science.gov (United States)

    Hoffman, Eric W.; Pinkleton, Bruce E.; Weintraub Austin, Erica; Reyes-Velázquez, Wanda

    2014-01-01

    Objective: Alcohol marketers have increasingly moved their advertising efforts into digital and social media venues. As a result, the purpose of this study is to investigate associations between students' use of social media, their exposure to alcohol marketing messages through social media, and their alcohol-related beliefs and behaviors.…

  13. Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress.

    Directory of Open Access Journals (Sweden)

    Martha L Slattery

    Full Text Available Several diet and lifestyle factors may impact health by influencing oxidative stress levels. We hypothesize that level of cigarette smoking, alcohol, anti-inflammatory drugs, and diet alter gene expression. We analyzed RNA-seq data from 144 colon cancer patients who had information on recent cigarette smoking, recent alcohol consumption, diet, and recent aspirin/non-steroidal anti-inflammatory use. Using a false discovery rate of 0.1, we evaluated gene differential expression between high and low levels of exposure using DESeq2. Ingenuity Pathway Analysis (IPA was used to determine networks associated with de-regulated genes in our data. We identified 46 deregulated genes associated with recent cigarette use; these genes enriched causal networks regulated by TEK and MAP2K3. Different differentially expressed genes were associated with type of alcohol intake; five genes were associated with total alcohol, six were associated with beer intake, six were associated with wine intake, and four were associated with liquor consumption. Recent use of aspirin and/or ibuprofen was associated with differential expression of TMC06, ST8SIA4, and STEAP3 while a summary oxidative balance score (OBS was associated with SYCP3, HDX, and NRG4 (all up-regulated with greater oxidative balance. Of the dietary antioxidants and carotenoids evaluated only intake of beta carotene (1 gene, Lutein/Zeaxanthine (5 genes, and Vitamin E (4 genes were associated with differential gene expression. There were similarities in biological function of de-regulated genes associated with various dietary and lifestyle factors. Our data support the hypothesis that diet and lifestyle factors associated with oxidative stress can alter gene expression. However genes altered were unique to type of alcohol and type of antioxidant. Because of potential differences in associations observed between platforms these findings need replication in other populations.

  14. Factors Associated With the Development of Breast Cancer-Related Lymphedema After Whole-Breast Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Chirag; Wilkinson, John Ben; Baschnagel, Andrew [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Ghilezan, Mihai [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); William Beaumont School of Medicine, Oakland University, Royal Oak, MI (United States); Riutta, Justin; Dekhne, Nayana; Balaraman, Savitha [Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI (United States); William Beaumont School of Medicine, Oakland University, Royal Oak, MI (United States); Mitchell, Christina; Wallace, Michelle [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Vicini, Frank, E-mail: fvicini@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI (United States); William Beaumont School of Medicine, Oakland University, Royal Oak, MI (United States)

    2012-07-15

    Purpose: To determine the rates of breast cancer-related lymphedema (BCRL) in patients undergoing whole-breast irradiation as part of breast-conserving therapy (BCT) and to identify clinical, pathologic, and treatment factors associated with its development. Methods and Materials: A total of 1,861 patients with breast cancer were treated at William Beaumont Hospital with whole-breast irradiation as part of their BCT from January 1980 to February 2006, with 1,497 patients available for analysis. Determination of BCRL was based on clinical assessment. Differences in clinical, pathologic, and treatment characteristics between patients with BCRL and those without BCRL were evaluated, and the actuarial rates of BCRL by regional irradiation technique were determined. Results: The actuarial rate of any BCRL was 7.4% for the entire cohort and 9.9%, 14.7%, and 8.3% for patients receiving a supraclavicular field, posterior axillary boost, and internal mammary irradiation, respectively. BCRL was more likely to develop in patients with advanced nodal status (11.4% vs. 6.3%, p = 0.001), those who had a greater number of lymph nodes removed (14 nodes) (9.5% vs. 6.0%, p = 0.01), those who had extracapsular extension (13.4% vs. 6.9%, p = 0.009), those with Grade II/III disease (10.8% vs. 2.9%, p < 0.001), and those who received adjuvant chemotherapy (10.5% vs. 6.7%, p = 0.02). Regional irradiation showed small increases in the rates of BCRL (p = not significant). Conclusions: These results suggest that clinically detectable BCRL will develop after traditional BCT in up to 10% of patients. High-risk subgroups include patients with advanced nodal status, those with more nodes removed, and those who receive chemotherapy, with patients receiving regional irradiation showing a trend toward increased rates.

  15. Factors Associated With the Development of Breast Cancer–Related Lymphedema After Whole-Breast Irradiation

    International Nuclear Information System (INIS)

    Purpose: To determine the rates of breast cancer–related lymphedema (BCRL) in patients undergoing whole-breast irradiation as part of breast-conserving therapy (BCT) and to identify clinical, pathologic, and treatment factors associated with its development. Methods and Materials: A total of 1,861 patients with breast cancer were treated at William Beaumont Hospital with whole-breast irradiation as part of their BCT from January 1980 to February 2006, with 1,497 patients available for analysis. Determination of BCRL was based on clinical assessment. Differences in clinical, pathologic, and treatment characteristics between patients with BCRL and those without BCRL were evaluated, and the actuarial rates of BCRL by regional irradiation technique were determined. Results: The actuarial rate of any BCRL was 7.4% for the entire cohort and 9.9%, 14.7%, and 8.3% for patients receiving a supraclavicular field, posterior axillary boost, and internal mammary irradiation, respectively. BCRL was more likely to develop in patients with advanced nodal status (11.4% vs. 6.3%, p = 0.001), those who had a greater number of lymph nodes removed (14 nodes) (9.5% vs. 6.0%, p = 0.01), those who had extracapsular extension (13.4% vs. 6.9%, p = 0.009), those with Grade II/III disease (10.8% vs. 2.9%, p < 0.001), and those who received adjuvant chemotherapy (10.5% vs. 6.7%, p = 0.02). Regional irradiation showed small increases in the rates of BCRL (p = not significant). Conclusions: These results suggest that clinically detectable BCRL will develop after traditional BCT in up to 10% of patients. High-risk subgroups include patients with advanced nodal status, those with more nodes removed, and those who receive chemotherapy, with patients receiving regional irradiation showing a trend toward increased rates.

  16. Prevalence and risk factors associated with nutrition-related noncommunicable diseases in the Eastern Mediterranean region

    Directory of Open Access Journals (Sweden)

    Musaiger AO

    2012-02-01

    Full Text Available Abdulrahman O Musaiger1, Hazzaa M Al-Hazzaa21Nutrition and Health Studies Unit, Deanship of Scientific Research, University of Bahrain, Bahrain, and Arab Center for Nutrition, Bahrain; 2Exercise Physiology Laboratory, Department of Physical Education and Movement Science, College of Education, and Scientific Board, Obesity Research Chair, King Saud University, Riyadh, Saudi ArabiaAbstract: This paper reviews the current situation concerning nutrition-related noncommunicable diseases (N-NCDs and the risk factors associated with these diseases in the Eastern Mediterranean region (EMR. A systematic literature review of studies and reports published between January 1, 1990 and September 15, 2011 was conducted using the PubMed and Google Scholar databases. Cardiovascular disease, type 2 diabetes, metabolic syndrome, obesity, cancer, and osteoporosis have become the main causes of morbidity and mortality, especially with progressive aging of the population. The estimated mortality rate due to cardiovascular disease and diabetes ranged from 179.8 to 765.2 per 100,000 population, with the highest rates in poor countries. The prevalence of metabolic syndrome was very high, ranging from 19% to 45%. The prevalence of overweight and obesity (body mass index ≥25 kg/m2 has reached an alarming level in most countries of the region, ranging from 25% to 82%, with a higher prevalence among women. The estimated mortality rate for cancer ranged from 61.9 to 151 per 100,000 population. Osteoporosis has become a critical problem, particularly among women. Several risk factors may be contributing to the high prevalence of N-NCDs in EMR, including nutrition transition, low intake of fruit and vegetables, demographic transition, urbanization, physical inactivity, hypertension, tobacco smoking, stunting of growth of preschool children, and lack of nutrition and health awareness. Intervention programs to prevent and control N-NCDs are urgently needed, with special focus

  17. HIV-associated lymphoma: histopathology and association with Epstein-Barr virus genome related to clinical, immunological and prognostic features

    DEFF Research Database (Denmark)

    Pedersen, C; Gerstoft, J; Lundgren, Jens Dilling;

    1991-01-01

    All 51 cases of HIV-related malignant lymphoma in Denmark diagnosed from 1983 to 1989 were reviewed. There were 12 Burkitt-type lymphomas, 30 immunoblast-rich lymphomas and 9 other lymphomas. Patients with immunoblast-rich lymphomas had significantly lower CD4 cell counts (median 60 vs. 188 x 10......(6)/l, P less than 0.05), and more often a history of previous AIDS-defining illnesses (50% vs. 0%, P less than 0.005), compared with patients with Burkitt-type lymphomas. Epstein-Barr virus (EBV) DNA was demonstrated in 14 of 19 immunoblast-rich tumours, and in 2 of 7 Burkitt-type lymphomas (P = 0......-rich morphology, and may be linked to EBV, whereas the other may occur in the absence of immunosuppression, is often of Burkitt-type morphology, and is probably not linked to EBV. In addition to these two main types, other non-Hodgkin lymphomas and Hodgkin's disease do occur....

  18. CDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children.

    Directory of Open Access Journals (Sweden)

    Mathias Rask-Andersen

    Full Text Available Five novel loci recently found to be associated with body mass in two GWAS of East Asian populations were evaluated in two cohorts of Swedish and Greek children and adolescents. These loci are located within, or in the proximity of: CDKAL1, PCSK1, GP2, PAX6 and KLF9. No association with body mass has previously been reported for these loci in GWAS performed on European populations. The single nucleotide polymorphisms (SNPs with the strongest association at each loci in the East Asian GWAS were genotyped in two cohorts, one obesity case control cohort of Swedish children and adolescents consisting of 496 cases and 520 controls and one cross-sectional cohort of 2293 nine-to-thirteen year old Greek children and adolescents. SNPs were surveyed for association with body mass and other phenotypic traits commonly associated with obesity, including adipose tissue distribution, insulin resistance and daily caloric intake. No association with body mass was found in either cohort. However, among the Greek children, association with insulin resistance could be observed for the two CDKAL1-related SNPs: rs9356744 (β = 0.018, p = 0.014 and rs2206734 (β = 0.024, p = 0.001. CDKAL1-related variants have previously been associated with type 2 diabetes and insulin response. This study reports association of CDKAL1-related SNPs with insulin resistance, a clinical marker related to type 2 diabetes in a cross-sectional cohort of Greek children and adolescents of European descent.

  19. The Associations between Information and Communication Technology (ICT) and Peer and Parent Relations in Early Adolescence

    Science.gov (United States)

    Punamaki, Raija-Leena; Wallenius, Marjut; Holtto, Hanna; Nygard, Clas-Hakan; Rimpela, Arja

    2009-01-01

    The study aims were, first, to examine the associations between the type and intensity of ICT (Information and Communication Technology) and peer and parent relationships. Second, the study explored gender- and age-specific ICT usage and their associations with peer and parent relationships. The participants were 478 Finnish 10- and 13-year-old…

  20. The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

    NARCIS (Netherlands)

    Eussen, S.J.P.M.; Ueland, P.M.; Clarke, R.; Blom, H.J.; Hoefnagels, W.H.L.; Staveren, van W.A.; Groot, de C.P.G.M.

    2007-01-01

    The importance of the one-carbon metabolites, choline and homocysteine, to brain function is well known. However, the associations between the one-carbon metabolites choline, betaine, methionine and dimethylglycine with cognition in elderly are unclear. We therefore examined the associations of thes

  1. The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people.

    NARCIS (Netherlands)

    Eussen, S.; Ueland, P.M.; Clarke, R.; Blom, H.J.; Hoefnagels, W.H.L.; Staveren, W.A. van; Groot, L.C. de

    2007-01-01

    The importance of the one-carbon metabolites, choline and homocysteine, to brain function is well known. However, the associations between the one-carbon metabolites choline, betaine, methionine and dimethylglycine with cognition in elderly are unclear. We therefore examined the associations of thes

  2. N-ary Relations of Association in Class Diagrams: Design Patterns

    Directory of Open Access Journals (Sweden)

    Sergievskiy Maxim

    2016-02-01

    Full Text Available Most of the technology of object-oriented development relies on the use of UML diagrams, in particular, class diagrams. CASE tools, used for automation of object-oriented development, often do not support n-ary associations in the class diagrams, and their implementation in the form of program code in contrast to binary rather time-consuming. The article will show how in some cases it is possible to move from the n-ary association between classes to binary and how can reduce the number of objects. The rules to transform models, that contain n-ary association, will be presented in the form of design patterns. Proposed three new design patterns can be used in the process of developing software systems. These patterns describe transformations of n-ary (often ternary associations occur between classes in binary and the introduction of additional classes and binary association with the aim of optimizing the model.

  3. Associations of Obesity Genes with Obesity-related Outcomes in Multiethnic Children

    Science.gov (United States)

    Klimentidis, Yann C.; Chen, Guo-Bo; López-Alarcón, Mardia; Harris, Jacqueline J.; Duarte, Christine W.; Fernández, José R.

    2012-01-01

    Background and Aims Genome-wide association studies (GWAS) have identified several loci that are associated with body mass index (BMI = kg/m2). However, little is known regarding whether the genetic basis of BMI differs among children of diverse racial/ethnic backgrounds, how the cumulative effect of these genes influences weight, or the contribution of these variants to body composition. This study examined the association between 17 GWAS-identified loci located in 16 genes and body-composition phenotypes in a multiethnic pediatric sample and evaluated the association of a composite genetic risk score with these phenotypes. Methods Anthropometric measures of BMI, waist circumference and waist-to-hip ratio were obtained in a sample of 298 children. Lean and fat mass were obtained from dual-energy X-ray absorptiometry (DXA). Genotypes of 17 single nucleotide polymorphisms (SNPs) were tested for association with the phenotypic measures, adjusted by standard covariates and estimates of genetic admixture. Results Both SNPs rs8050136 and rs9939609 in FTO were associated with BMI and waist circumference in a direction opposite to that observed among adults, and an inverse association was detected between the risk variant in MC4R and total lean body mass. Lean body mass mediated the association between TMEM18 and BMI. The association between the genetic risk score and body composition differed according to ethnic/racial classification. Conclusions Our findings suggest that genetic associations with BMI among children are different from those in adults, that some loci may operate through lean body mass, and that genetic risk scores will not have universal applicability across ethnic/racial groups. PMID:22051089

  4. The Association between Plasma 25-Hydroxyvitamin D and Subgroups in Age-Related Macular Degeneration

    DEFF Research Database (Denmark)

    Singh, Amardeep; Falk, Mads Krüger; Subhi, Yousif;

    2013-01-01

    To evaluate potential differences in plasma 25-hydroxyvitamin in subtypes of age-related macular degeneration (AMD), and in patients in Clinical Age-Related Maculopathy Staging (CARMS) group 5 with or without subretinal fibrosis....

  5. Association study of the oestrogen signalling pathway genes in relation to age at natural menopause

    Indian Academy of Sciences (India)

    Li-Na He; Dong-Hai Xiong; Yong-Jun Liu; Feng Zhang; Robert R. Recker; Hong-Wen Deng

    2007-12-01

    Genetic factors play a significant role in influencing the variation of age at natural menopause (AANM). Estrogen receptor (ESR2), is an important factor in the mechanism of action of estrogen, while the aromatase gene (CYP19) and the 17-alpha-hydroxylase gene (CYP17) are involved in the biosynthesis of estrogen. We tested whether polymorphisms of ESR2, CYP19 and CYP17 genes are associated with AANM in Caucasian females. A total of 52 SNPs (17 for ESR2, 28 for CYP19, and 7 for CYP17) were successfully genotyped for 229 Caucasian women having experienced natural menopause. Comprehensive statistical analyses focusing on the association of these genes with AANM were conducted. The effects of age, height and age at menarche on AANM were adjusted when conducting association analyses. We found that six SNPs (2, 6-7, 9, 13 and 16) within ESR2 were not significantly associated with AANM after Bonferroni correction. However, two blocks of ESR2 were associated with AANM. For CYP19, two SNPs (24 and 27) were nominally associated with AANM. No significant association was observed between CYP17 and AANM. Our results suggest that genetic variation in the ESR2 and CYP19 genes may influence the variation in AANM in Caucasian women.

  6. Plaque pH and associated parameters in relation to caries.

    Science.gov (United States)

    Dong, Y M; Pearce, E I; Yue, L; Larsen, M J; Gao, X J; Wang, J D

    1999-01-01

    Intensified plaque acidogenicity in caries-prone subjects was reported many years ago, but emerging evidence has suggested that the relationship may not be as strong as once thought. We have now determined a range of acidogenicity variables in subjects having both caries prevalence and incidence data, and have included plaque mineral data in the analysis. pH measurements were made in 20 randomly selected subjects from a high-caries group (mean DMFS = 8. 95) and 20 from a caries-free group of Beijing children aged 12 years participating in a caries prediction study. Subgroups with a 12-month DMFS increment >/=2 or = 0 were also formed from the two groups, respectively. Measurements were made with an iridium oxide electrode inserted between teeth 13/14, 23/24, 34/35 and 44/45, before and every 5 min for 30 min after rinsing with 10% sucrose, and the 4 resulting 'Stephan curves' averaged using a plaque pH analysis program. Supragingival plaque was collected from buccal and lingual smooth surfaces of posterior and upper anterior teeth and its acid extract analysed for Ca, P and F. Caries-free subjects (based on past experience) had a significantly higher maximum plaque pH and pH value after 30 min (reflecting a faster return to resting pH), a lower minimum enamel dissolution capacity of plaque and recorded less time below pH 7.0 than did high-caries subjects. No other differences were significant, including those of the principal acidogenic parameters 'minimum pH attained after a sugar rinse', 'curve area below the critical pH of 5.5' and 'time below the critical pH'. Selection of the caries groups on the basis of both experience and incidence did not reveal significant differences in more parameters. Upper arch plaque was significantly more acidogenic than lower arch plaque, and there was a consistently strong association between upper and lower arch values in individuals. Ca, P and F in the subjects' plaque had little or no influence on the principal acidogenic

  7. Adolescent Resource Control: Associations with Physical and Relational Aggression, Prosocial and Withdrawn Behaviors, and Peer Regard

    Science.gov (United States)

    Findley, Danielle; Ojanen, Tiina

    2013-01-01

    This study examined adolescent coercive and prosocial resource control strategies in relation to various indices of peer-reported behaviors and peer regard ("N" = 384; 12-14 years). Coercive control was uniquely positively related to physical and relational aggression and peer disliking, and negatively to prosocial behaviors when…

  8. Chinese Adolescents' Social Status Goals: Associations with Behaviors and Attributions for Relational Aggression

    Science.gov (United States)

    Wright, Michelle F.; Li, Yan; Shi, Junqi

    2014-01-01

    This study examined two social status goals in relation to aggressive and prosocial behaviors as well as attributions for relational aggression among 477 (244 girls) Chinese early adolescents. Findings indicate that, after controlling for each other, the social preference goal was negatively related to self-reported overt aggression, and…

  9. Association between plasma testosterone and work-related neck and shoulder disorders among female workers

    DEFF Research Database (Denmark)

    Kaergaard, A.; Hansen, A. M.; Rasmussen, K.;

    2000-01-01

    OBJECTIVES: The aims were to study the association between anabolic hormone testosterone in plasma and the presence of musculoskeletal disorders among female workers and to study the association between changes in testosterone and changes in musculoskeletal complaints. METHODS: In a cross....... However, this finding may well be due to a strong plant influence in that marked changes in testosterone levels were observed for 2 of the 3 participating plants. CONCLUSIONS: There is some indication of an association between musculoskeletal disorders in the neck and shoulders and a low level of free...

  10. IgG4-Related Mikulicz's Disease Associated with Thyroiditis:a Case Report and Review of the Literature

    Institute of Scientific and Technical Information of China (English)

    Yujiao Zhang; Yi Du; Kaijun Li; Jianfeng He

    2014-01-01

    Purpose:To report an unusual case of IgG4-related Mikulicz's disease associated with thyroiditis. Case report:.We describe a 25-year-old Chinese man who presented with bilateral,.painless swellings of the lachrymal glands,.parotid glands,.and thyroid nodules..The patient un-derwent left-sided dacryoadenectomy and the diagnosis of IgG4-related Mikulicz's disease was pathologically confirmed. The size of the right-sided lachrymal gland and parotid glands recovered fundamentally after one month of glucocorticoid therapy. Conclusion:.IgG4-related Mikulicz's disease associated with thyroiditis should be considered in the differential diagnosis of bilateral swellings of lachrymal glands, salivary glands, and thyroid nodules. Surgical excision is recommended in order to treat the tumor and to ensure the pathological diagnosis. Glu-cocorticoid therapy should be considered in association with surgery after removal. (Eye Science 2014; 29:47-52).

  11. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

    DEFF Research Database (Denmark)

    Møller-Larsen, Steffen; Nyegaard, Mette; Haagerup, Annette;

    2008-01-01

    BACKGROUND: Toll-like receptors (TLRs) are structurally and functionally related and play important roles in the innate and adaptive immune system. By genome scanning, evidence of linkage between chromosome Xp22 and asthma and related atopic disorders has previously been obtained. Xp22 harbours the...... TLR7 and TLR8 genes. METHODS: The involvement of TLR7 and TLR8 in the aetiology of asthma and related disorders was investigated by a family based association analysis of two independently ascertained family samples comprising 540 and 424 individuals from 135 and 100 families, respectively. Ten...... affected individuals from families showing evidence of linkage to Xp22 were screened for sequence variations in TLR7 and 8, and nine single nucleotide polymorphisms (SNPs) identified were tested for association. RESULTS: In both samples, significant associations were observed for single SNPs and haplotypes...

  12. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

    DEFF Research Database (Denmark)

    Møller-Larsen, Steffen; Nyegaard, Mette; Haagerup, Annette;

    2008-01-01

    BACKGROUND: Toll-like receptors (TLRs) are structurally and functionally related and play important roles in the innate and adaptive immune system. By genome scanning, we have previously obtained evidence of linkage between chromosome Xp22 and asthma and related atopic disorders. Xp22 harbours the...... TLR7 and TLR8 genes. METHODS: We investigated the involvement of TLR7 and TLR8 in the aetiology of asthma and related disorders by a family based association analysis of two independently ascertained family samples comprising 540 and 424 individuals from 135 and 100 families, respectively. Ten...... affected individuals from families showing evidence of linkage to Xp22 were screened for sequence variations in TLR7 and 8, and 9 single nucleotide polymorphisms (SNPs) identified were tested for association. RESULTS: In both samples, significant associations were observed for single SNPs and haplotypes of...

  13. Fe–Ti–V–P ore deposits associated with Proterozoic massif-type anorthosites and related rocks

    OpenAIRE

    Charlier, Bernard; Namur, Olivier; Bolle, Olivier; Latypov, Rais; Duchesne, Jean-Clair

    2015-01-01

    Magmatic rocks containing economic concentrations of iron, titanium, vanadium and phosphorous are commonly associated with massif-type anorthosites and related rocks. This rock association is part of the anorthosite–mangerite–charnockite–(rapakivi-)granite suites that are restricted to the Proterozoic. Understanding the geochemistry and emplacement mechanisms of ilmenite, magnetite and apatite ore deposits is crucial for exploration, efficient mining operations and ore processing. This review...

  14. Associations between active video gaming and other energy-balance related behaviours in adolescents: a 24-hour recall diary study

    OpenAIRE

    Simons, Monique; Mai J M Chinapaw; Brug, Johannes; Seidell, Jaap; Vet, Emely

    2015-01-01

    Background Active video games may contribute to reducing time spent in sedentary activities, increasing physical activity and preventing excessive weight gain in adolescents. Active video gaming can, however, only be beneficial for weight management when it replaces sedentary activities and not other physical activity, and when it is not associated with a higher energy intake. The current study therefore examines the association between active video gaming and other energy-balance-related beh...

  15. Post-partum sequential occurrence of two diverse transfusion reactions (transfusion associated circulatory overload and transfusion related acute lung injury)

    OpenAIRE

    Rudrashish Haldar; Sukhen Samanta

    2013-01-01

    Transfusion associated circulatory overload (TACO) and transfusion related acute lung injury (TRALI) are two dissimilar pathological conditions associated with transfusion of blood products where the time course of the events and clinical presentation overlap leading to uncertainty in establishing the diagnosis and initiating the treatment, which otherwise differs. We encountered a case where a patient of post-partum hemorrhage developed TACO in the immediate post-operative period due to aggr...

  16. Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.

    OpenAIRE

    McKay, Gareth J; Patterson, Chris C; Chakravarthy, Usha; Dasari, Shilpa; Klaver, Caroline C.; Vingerling, Johannes R; Ho, Lintje; de Jong, Paulus T V M; Fletcher, Astrid E.; Young, Ian S.; Seland, Johan H.; Rahu, Mati; Soubrane, Gisele; Tomazzoli, Laura; Topouzis, Fotis

    2011-01-01

    Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n = 21,160) demonstrating associations between late AMD and APOε4 (odds ratio [OR] = 0.72 per haplo...

  17. The association between HIV/AIDS-related knowledge and perception of risk for infection

    DEFF Research Database (Denmark)

    Ndugwa Kabwama, Steven; Berg-Beckhoff, Gabriele

    2015-01-01

    This systematic review tries to elucidate the association between what people know about HIV/AIDS and how they perceive their risk of infection. The initial search for articles yielded 1,595 abstracts, 16 of which met the inclusion criteria. Five studies found a positive correlation, four reported...... a negative correlation and seven found no association between knowledge and risk perception. It was found that the existing psychometrically sound measure of HIV/AIDS risk perception had not been used in any of the studies. The context in which the risk is assessed is pivotal to whether an...... association between knowledge and the perceived risk is found. Biases in judgement such as optimistic bias, psychological distancing, anchoring bias and overconfidence also explain how knowledge may fail to predict risk perception. It was concluded that the association between HIV/AIDS knowledge and risk...

  18. Are chronic myeloproliferative neoplasms associated with age-related macular degeneration?

    DEFF Research Database (Denmark)

    Bak, M.; Sorensen, T. L.; Flachs, E. M.;

    2015-01-01

    Background. Patients with Chronic Myeloproliferative Neoplasms (MPNs) already have increased comorbidity at time of diagnosis, and studies show association with ophthalmic manifestations. Retinal vascular symptoms including vascular occlusions and hemorrhages are present, but other manifestations...

  19. Associations among treatment-related neurological risk factors and neuropsychological functioning in survivors of childhood brain tumor.

    Science.gov (United States)

    McCurdy, Mark D; Rane, Shruti; Daly, Brian P; Jacobson, Lisa A

    2016-03-01

    Adverse neurological side effects associated with childhood brain tumors and their treatments contribute to long-term neurocognitive morbidity. Measures designed to quantify tumor-related risk factors are lacking. The neurological predictor scale (NPS) is designed to assess treatment-related neurological risks. Preliminary validation established associations between the NPS and global cognitive functioning in this population, though its associations with specific neurobehavioral domains has yet to be addressed. Participants referred for outpatient neuropsychological assessment completed performance-based measures of intellectual, attentional, working memory, motor speed, and executive abilities. Caregivers completed ratings of adaptive functioning. Neuropsychological and adaptive data were available for 100 brain tumor survivors (51 % female), ages 6 to 22 years (M = 12.83, SD = 4.37). Total NPS scores were generated via retrospective medical record review. Total NPS scores were significantly associated with several neurocognitive composite scores including verbal reasoning and working memory, after controlling for years post-diagnosis (ps  .05). Results indicate that the NPS is associated with performance-based neurocognitive functioning and executive skills but not with functioning in specific caregiver-reported adaptive behavior domains. The NPS offers some value as a resource for understanding associations between treatment-related neurological risks and select aspects of neurocognitive morbidity. Future studies should examine whether the NPS can aid in planning appropriate therapeutic intervention as survivors progress into early adulthood. PMID:26725098

  20. From expression pattern to genetic association in asthma and asthma-related phenotypes

    OpenAIRE

    Vaillancourt Vanessa T; Bordeleau Martine; Laviolette Michel; Laprise Catherine

    2012-01-01

    Abstract Background Asthma is a complex disease characterized by hyperresponsiveness, obstruction and inflammation of the airways. To date, several studies using different approaches as candidate genes approach, genome wide association studies, linkage analysis and genomic expression leaded to the identification of over 300 genes involved in asthma pathophysiology. Combining results from two studies of genomic expression, this study aims to perform an association analysis between genes differ...

  1. A Fast Distributed Algorithm for Association Rule Mining Based on Binary Coding Mapping Relation

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Association rule mining is an important issue in data mining. The paper proposed an binary system based method to generate candidate frequent itemsets and corresponding supporting counts efficiently, which needs only some operations such as "and", "or" and "xor". Applying this idea in the existed distributed association rule mining algorithm FDM, the improved algorithm BFDM is proposed. The theoretical analysis and experiment testify that BFDM is effective and efficient.

  2. The Dysexecutive Syndrome Associated with Ischaemic Vascular Disease and Related Subcortical Neuropathology: A Boston Process Approach

    OpenAIRE

    Melissa Lamar; Price, Cate C.; Tania Giovannetti; Rod Swenson; Libon, David J.

    2010-01-01

    The introduction of diagnostic criteria for vascular dementia has helped to re-define the impact of various subcortical neuropathologies on aging; however, state-of-the-art neuroimaging techniques and autopsy studies suggest that not all structural brain alterations associated with vascular dementia are exclusive to this neurodegenerative process alone. Thus, a detailed analysis of the cognitive phenotype associated with ischaemic vascular disease is key to our understanding of subcortical ne...

  3. Associations between the built environment, total, recreational, and transit-related physical activity

    OpenAIRE

    de Sa, Eric; Ardern, Chris I.

    2014-01-01

    Background Many aspects of the built, physical environment have been shown to be associated with physical activity, but little research has focused on the unique circumstances and urban form of the suburban environment. The following analyses explore the associations between features of the built environment and components of overall physical activity, after accounting for neighborhood variability using hierarchical linear modeling. Methods These analyses utilized regionally-specific Geograph...

  4. The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

    OpenAIRE

    Eussen, S.J.P.M.; Ueland, P. M.; Clarke, R; Blom, H.J.; Hoefnagels, W.H.L.; Staveren, van, R.; Groot, de, W.T.

    2007-01-01

    The importance of the one-carbon metabolites, choline and homocysteine, to brain function is well known. However, the associations between the one-carbon metabolites choline, betaine, methionine and dimethylglycine with cognition in elderly are unclear. We therefore examined the associations of these metabolites with cognition in a double-blind, placebo-controlled trial. Individuals (n 195) were randomized to receive daily oral capsules with either 1000 ¿g cobalamin (vitamin B12), or 1000 ¿g ...

  5. Perceived neighborhood environmental attributes associated with adults’ transport-related walking and cycling: Findings from the USA, Australia and Belgium

    Directory of Open Access Journals (Sweden)

    Van Dyck Delfien

    2012-06-01

    Full Text Available Abstract Background Active transportation has the potential to contribute considerably to overall physical activity levels in adults and is likely to be influenced by neighborhood-related built environment characteristics. Previous studies that examined the associations between built environment attributes and active transportation, focused mainly on transport-related walking and were conducted within single countries, limiting environmental variability. We investigated the direction and shape of relationships of perceived neighborhood attributes with transport-related cycling and walking in three countries; and examined whether these associations differed by country and gender. Methods Data from the USA (Baltimore and Seattle, Australia (Adelaide and Belgium (Ghent were pooled. In total, 6,014 adults (20–65 years, 55.7% women were recruited in high-/low-walkable and high-/low-income neighborhoods. All participants completed the Neighborhood Environmental Walkability Scale and the International Physical Activity Questionnaire. Generalized additive mixed models were used to estimate the strength and shape of the associations. Results Proximity to destinations, good walking and cycling facilities, perceiving difficulties in parking near local shopping areas, and perceived aesthetics were included in a ‘cyclability’ index. This index was linearly positively related to transport-related cycling and no gender- or country-differences were observed. The ‘walkability’ index consisted of perceived residential density, land use mix access, proximity of destinations and aesthetics. A non-linear positive relationship with transport-related walking was found. This association was stronger in women than in men, and country-specific associations were identified: the strongest association was observed in Seattle, the weakest in Adelaide. In Ghent, the association weakened at higher levels of walkability. Conclusions For cycling, consistent

  6. Associations between relational sexual behaviour, pornography use, and pornography acceptance among US college students.

    Science.gov (United States)

    Willoughby, Brian J; Carroll, Jason S; Nelson, Larry J; Padilla-Walker, Laura M

    2014-01-01

    Pornography use among emerging adults in the USA has increased in recent decades, as has the acceptance of such consumption. While previous research has linked pornography use to both positive and negative outcomes in emerging adult populations, few studies have investigated how attitudes toward pornography may alter these associations, or how examining pornography use together with other sexual behaviours may offer unique insights into the outcomes associated with pornography use. Using a sample of 792 emerging adults, the present study explored how the combined examination of pornography use, acceptance, and sexual behaviour within a relationship might offer insight into emerging adults' development. Results suggested clear gender differences in both pornography use and acceptance patterns. High male pornography use tended to be associated with high engagement in sex within a relationship and was associated with elevated risk-taking behaviours. High female pornography use was not associated with engagement in sexual behaviours within a relationship and was general associated with negative mental health outcomes. PMID:25023726

  7. Minority stress is longitudinally associated with alcohol-related problems among sexual minority women.

    Science.gov (United States)

    Wilson, Sarah M; Gilmore, Amanda K; Rhew, Isaac C; Hodge, Kimberley A; Kaysen, Debra L

    2016-10-01

    Compared to sexual minority men and heterosexual women, sexual minority women report elevated alcohol use in young adulthood. Heavy alcohol use and alcohol use disorders disproportionately affect sexual minority women across the lifespan, yet there is limited research investigating reasons for such associations. The present study investigates longitudinal associations between minority stress and both alcohol use as well as self-rated drinking consequences. Participants (N=1057) were self-identified lesbian (40.5%) and bisexual (59.5%) women between the ages of 18 to 25 recruited from across the U.S. using online advertisements. Participants completed four annual surveys. Hurdle mixed effects models were used to assess associations between minority stress and typical weekly drinking and drinking consequences one year later. Minority stress was not significantly associated with subsequent typical drinking. However, minority stress was significantly associated with having any alcohol consequences as well as the count of alcohol consequences one year later after controlling for covariates. Consistent with extant literature, this study provides evidence for a prospective association between minority stress experienced by sexual minority women and drinking consequences. This study also provides support for the potential impact of efforts to reduce minority stress faced by sexual minority women. PMID:27249806

  8. ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women.

    Science.gov (United States)

    Zouine, S; Marnissi, F; Otmani, N; Bennani Othmani, M; El Wafi, M; Kojok, K; Zaid, Y; Tahiri Jouti, N; Habti, N

    2016-07-01

    The association between blood groups ABO and different types of diseases was established in several previous studies. Our aim was to seek the possible association between the ABO blood group and breast cancer-associated prognostic factors. The Chi-squared analytic test was used to compare phenotypic ABO distribution among Moroccan blood donors and 442 cases of women suffering from breast carcinoma with archived files in Maternity Ward of University Hospital C.H.U Ibn Rochd between 2008 and 2011. High incidence of breast carcinoma was observed in blood type B patients (p type B was associated with breast carcinomas overexpressing human epidermal growth factor receptor HER2 (p risk of cancer at age over 70 years (p type A was associated with high risk of cancer among women younger than 35 years old. Blood type A and AB were associated with high incidence of lymph node metastasis (p type and estrogen receptor-positive tumor. Patients with blood group A, B, and AB were more likely to develop aggressive breast carcinoma. Further follow-up studies are necessary to clarify the role of ABH antigens in the progression of breast carcinoma. PMID:27241035

  9. A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease

    OpenAIRE

    Kyotaro Ohno; Yasuharu Sato; Koh-ichi Ohshima; Katsuyoshi Takata; Tomoko Miyata-Takata; Mai Takeuchi; Yuka Gion; Tomoyasu Tachibana; Yorihisa Orita; Toshihiro Ito; Swerdlow, Steven H.; Tadashi Yoshino

    2015-01-01

    We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL an...

  10. Associations between patient characteristics, social relations, diabetes management, quality of life, glycaemic control and emotional burden in type 1 diabetes

    DEFF Research Database (Denmark)

    Joensen, Lene E; Almdal, Thomas P; Willaing, Ingrid

    2016-01-01

    AIM: The objective was to investigate associations between emotional burden and a number of individual variables: patient characteristics, social relations, diabetes management in everyday life, generic quality of life and glycaemic control, including determining to what extend these variables...... associated with high emotional burden in type-1 diabetes. These findings may call for an expansion of the effort to decrease the emotional burden of diabetes for those who are heavily burdened. Future research should explore the causality of the explored associations as well as potential subgroup differences...

  11. Associations between Salivary Testosterone Levels, Androgen‐Related Genetic Polymorphisms, and Self‐Estimated Ejaculation Latency Time

    Directory of Open Access Journals (Sweden)

    Patrick Jern, PhD

    2014-08-01

    Conclusions: We were unable to find support for the hypothesis suggesting an association between T levels and ELT, possibly because of the low number of phenotypically extreme cases (the sample used in the present study was population based. Our results concerning genetic associations should be interpreted with caution until replication studies have been conducted. Jern P, Westberg L, Ankarberg‐Lindgren C, Johansson A, Gunst A, Sandnabba NK, and Santtila P. Associations between salivary testosterone levels, androgen‐related genetic polymorphisms, and self‐estimated ejaculation latency time. Sex Med 2014;2:107–114.

  12. Independent risk of mechanical ventilation for AIDS-related Pneumocystis carinii pneumonia associated with bronchoalveolar lavage neutrophilia

    DEFF Research Database (Denmark)

    Bang, D; Emborg, J; Elkjaer, J;

    2001-01-01

    failure requiring MV amongst patients with PCP treated in the era of adjunctive corticosteroid therapy. Furthermore, we studied factors associated with survival in relation to MV. Of 170 consecutive patients with AIDS-related PCP, 18 (11%) required MV. Thirteen of 18 ventilated patients died (72%). In a...... logistic regression analysis, higher age, increased bronchoalveolar lavage (BAL) neutrophilia and a positive BAL cytomegalovirus CMV culture were associated with the need of MV. In multivariate analyses, only BAL neutrophilia remained independently predictive of mechanical ventilation. In conclusion, short...

  13. Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium.

    Directory of Open Access Journals (Sweden)

    Faye L Norby

    Full Text Available Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF. To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc and low-density lipoprotein cholesterol (LDLc were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR and 95% confidence intervals (CI of AF per 1-standard deviation (SD increase of each lipid gene score.During a mean follow-up of 12.0 years, 5434 (8.4% incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI were 1.01 (0.98-1.03; 0.98 (0.96-1.01; 0.98 (0.95-1.02; 0.99 (0.97-1.02, respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI = 1.00 (0.97-1.03; 1.01 (0.99-1.04.In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.

  14. Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium

    Science.gov (United States)

    Norby, Faye L.; Agarwal, Sunil K.; Arking, Dan E.; Chasman, Daniel L.; Chen, Lin Y.; Eijgelsheim, Mark; Engström, Gunnar; Franco, Oscar H.; Heeringa, Jan; Hindy, George; Hofman, Albert; Lutsey, Pamela L.; Magnani, Jared W.; McManus, David D.; Orho-Melander, Marju; Pankow, James S.; Rukh, Gull; Schulz, Christina-Alexandra; Uitterlinden, André G.; Albert, Christine M.; Benjamin, Emelia J.; Gudnason, Vilmundur; Smith, J. Gustav; Stricker, Bruno H. C.; Alonso, Alvaro

    2016-01-01

    Background Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts. Methods We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score. Results During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98–1.03); 0.98 (0.96–1.01); 0.98 (0.95–1.02); 0.99 (0.97–1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97–1.03); 1.01 (0.99–1.04). Conclusions In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF. PMID:26999784

  15. The Associations of Eating-related Attitudinal Balance with Psychological Well-being and Eating Behaviors

    OpenAIRE

    Fuglestad, Paul T.; Bruening, Meg; Graham, Dan J.; Eisenberg, Marla E.; Neumark-Sztainer, Dianne R.

    2013-01-01

    This study used balance theory to illuminate the relations of eating-related attitudinal consistency between self and friends to psychological well-being and eating behaviors. It was hypothesized that attitudinal inconsistency, relative to consistency, would predict lower well-being and poorer eating habits. A population-based sample of 2287 young adults participating in Project EAT-III (Eating Among Teens and Young Adults) completed measures of psychological well-being, eating behaviors, and...

  16. Do body-related shame and guilt mediate the association between weight status and self-esteem?

    Science.gov (United States)

    Pila, Eva; Sabiston, Catherine M; Brunet, Jennifer; Castonguay, Andree L; O'Loughlin, Jennifer

    2015-05-01

    Individuals who are overweight or obese report body image concerns and lower self-esteem. However, little is known about the mechanisms underpinning these associations. The objective of this study was to test body-related shame and guilt as mediators in the association between weight status and self-esteem. Young adult participants (n = 790) completed assessments of self-esteem and body-related guilt and shame, and weight status indicators were measured by trained technicians. Findings from multiple mediation analyses suggest that body-related shame mediates the relationship between weight status and self-esteem. If replicated in longitudinal studies, these findings suggest that reducing body-related emotions may have important implications for improving self-esteem in clinical weight management. PMID:25903252

  17. FACTORS ASSOCIATED WITH MORTALITY AMONG PATIENTS WITH CENTRAL VENOUS CATHETER-RELATED BLOODSTREAM INFECTION IN AN INTENSIVE CARE UNIT

    Directory of Open Access Journals (Sweden)

    Priscilla Roberta Silva Rocha

    2012-01-01

    Full Text Available Central venous catheterization is a common practice in the management of critically ill patients and is associated with various complications, such as Bloodstream Infections (BSI, which are major determinants of increased morbidity, mortality and healthcare expenses. Few studies have addressed factors that predict mortality in patients with this complication. The aim of this study was to investigate factors associated with mortality in patients with Central Venous Catheter (CVC-related BSI in an intensive care unit of a tertiary care hospital in the Federal District, Brazil. This was a retrospective and observational study, in which all CVC-related BSI that occurred between January 2008 and December 2010 were reviewed. We obtained demographic, clinical, biochemical and microbiological data from medical records and investigated its association with mortality during ICU stay. There were 4,504 ICU admissions during the study period and 68 were complicated by CVC-related BSI (4.09 per 1000 catheter-days, most due to gram-negative organisms (45.6%. Overall mortality was 59.7%. Death risk was significantly associated with mechanical ventilation (OR 27.8, 95% CI 3.28-250, p-1 in survivors vs. 73.9 mg dL-1 in non-survivors, p = 0.001. Mortality was not associated with other clinical or biochemical features, neither with microbiological variables, although lethality was high among patients with gram-positive infections (77% Vs 58.33% for fungi and 54.83% for gram-negative. CVC-related BSI was associated with high absolute mortality, which was predicted by mechanical ventilation and a higher number of invasive devices other than the CVC. Knowledge of local factors predictive of mortality is critical for planning strategies to reduce death risk associated with this complication.

  18. Socio-demographic and health-related factors associated with cognitive impairment in the elderly in Taiwan

    OpenAIRE

    Chiu Herng-Chia; Chen Chun-Min; Lan Tsuo-Hung; Wu Ming-Shiang; Lan Tzuo-Yun

    2011-01-01

    Abstract Background Cognitive impairment is an age-related condition as the rate of cognitive decline rapidly increases with aging. It is especially important to better understand factors involving in cognitive decline for the countries where the older population is growing rapidly. The aim of this study was to examine the association between socio-demographic and health-related factors and cognitive impairment in the elderly in Taiwan. Methods We analysed data from 2119 persons aged 65 years...

  19. Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population

    OpenAIRE

    Oh, Il Hwan; Choi, Eun Young; Park, Joon-Sung; Lee, Chang Hwa

    2016-01-01

    Ferritin is considered to be a marker of the body’s iron stores and has a potential relationship with the systemic manifestations of inflammatory reactions. Data on the association between increased levels of serum ferritin and ocular problems are limited, particularly in relation to age-related macular degeneration (AMD). Serum ferritin levels, as a possible clinical parameter for predicting AMD, were analyzed in anthropometric, biochemical, and ophthalmologic data from a nation-wide, popula...

  20. Factors Associated With General and Sexual Alcohol-Related Consequences: An Examination of College Students Studying Abroad

    OpenAIRE

    Hummer, Justin F.; Pedersen, Eric R.; Mirza, Tehniat; LaBrie, Joseph W.

    2010-01-01

    This study contributes to the scarce research on U.S. college students studying abroad by documenting general and sexual negative alcohol-related risks and factors associated with such risk. The manner of drinking (quantity vs. frequency), predeparture expectations surrounding alcohol use while abroad, culture-related social anxiety, and perceived disparity between home and host cultures differentially predicted consequences abroad. The findings include important implications for student affa...

  1. Association of polypharmacy with fall-related fractures in older Taiwanese people: age- and gender-specific analyses

    OpenAIRE

    Pan, Hsueh-Hsing; Li, Chung-Yi; Chen, Tzeng-Ji; Su, Tung-ping; Wang, Kwua-Yun

    2014-01-01

    Objective To elucidate the associations between polypharmacy and age- and gender-specific risks of admission for fall-related fractures. Design Nested case–control study. Setting This analysis was randomly selected from all elderly beneficiaries in 2007–2008, and represents some 30% of the whole older insurers using Taiwan's National Health Insurance Research Database. Participants We identified 5933 cases newly admitted for fall-related fractures during 2007–2008, and 29 665 random controls ...

  2. A prospective cohort study on the association between coffee drinking and risk of non-gallstone-related acute pancreatitis.

    Science.gov (United States)

    Oskarsson, Viktor; Sadr-Azodi, Omid; Orsini, Nicola; Wolk, Alicja

    2016-05-01

    Only one previous study has examined the association between coffee consumption and risk of acute pancreatitis, and it found a reduced risk for alcohol-related episodes among high consumers of coffee. Therefore, we examined (1) the association between coffee consumption and risk of non-gallstone-related acute pancreatitis and (2) whether this association was modified by alcohol intake. Data were obtained from two prospective cohorts, the Cohort of Swedish Men and the Swedish Mammography Cohort, including 76 731 men and women (born 1914-1952). Coffee consumption was assessed at baseline with a FFQ, and the cohorts were followed up between 1998 and 2012 via linkage to national health registries. Hazard ratios were estimated using Cox models, with adjustment for potential confounding factors. During 1 035 881 person-years of total follow-up, 383 cases (246 in men and 137 in women) of incident non-gallstone-related acute pancreatitis were identified. Overall, and irrespective of whether a categorical or a continuous exposure model was used, we observed no association between coffee consumption and risk of non-gallstone-related acute pancreatitis (e.g. the multivariable-adjusted hazard ratio for each 1 cup/d increase in coffee consumption was 0·97; 95 % CI 0·92, 1·03). There was no evidence of effect modification by alcohol intake (P interaction=0·77). In conclusion, coffee consumption was not associated with risk of non-gallstone-related acute pancreatitis in this large prospective cohort study. Because of the limited number of epidemiological studies and their conflicting results, further research is needed to elucidate this potential association. PMID:26987519

  3. Apoptosis and apoptosis-associated parameters in relation to tamoxifen exposure in postmenopausal endometrium

    NARCIS (Netherlands)

    Mourits, MJE; Hollema, H; De Vries, EGE; Ten Hoor, KA; Willemse, PHB; Van der Zee, AGJ

    2002-01-01

    Tamoxifen increases endometrial cell proliferation and the incidence of endometrial cancer in postmenopausal women. The purpose of this study was to evaluate apoptosis and apoptosis-related factors in endometrium. in relation to tamoxifen exposure. We analyzed benign postmenopausal endometrium. from

  4. Association Rule Mining Based Extraction of Semantic Relations Using Markov Logic Network

    Directory of Open Access Journals (Sweden)

    K.Karthikeyan

    2014-10-01

    Full Text Available Ontology may be a conceptualization of a website into a human understandable, however machine - readable format consisting of entities, attributes, relationships and axioms. Ontologies formalize the in tentional aspects of a site, whereas the denotative part is provided by a mental object that contains assertions about instances of concepts and relations. Semantic relation it might be potential to extract the whole family - tree of a outstanding personalit y employing a resource like Wikipedia. In a way, relations describe the linguistics relationships among the entities involve that is beneficial for a higher understanding of human language. The relation can be identified from the result of concept hierarch y extraction. The existing ontology learning process only produces the result of concept hierarchy extraction. It does not produce the semantic relation between the concepts. Here, we have to do the process of constructing the predicates and also first ord er logic formula. Here, also find the inference and learning weights using Markov Logic Network. To improve the relation of every input and also improve the relation between the contents we have to propose the concept of ARSRE. This method can find the fre quent items between concepts and converting the extensibility of existing lightweight ontologies to formal one. The experimental results can produce the good extraction of semantic relations compared to state - of - art method

  5. Are child anxiety and somatization associated with pain in pain-related functional gastrointestinal disorders?

    Science.gov (United States)

    This study investigated individual and incremental contributions of somatization and trait anxiety to pain report in children with pain-related functional gastrointestinal disorders. Eighty children (7-10 years) with pain-related functional gastrointestinal disorders completed the State-Trait Anxiet...

  6. Interparental Conflict Styles and Parenting Behaviors: Associations with Overt and Relational Aggression among Chinese Children

    Science.gov (United States)

    Li, Yan; Putallaz, Martha; Su, Yanjie

    2011-01-01

    This study examined how interparental conflict styles related to Chinese children's overt and relational aggression directly and indirectly through parenting behaviors. Mothers (n = 670) and fathers (n = 570) reported their overt and covert interparental conflict styles and different parenting behaviors. Children's (n = 671) aggression was…

  7. Jet engine nozzle exit configurations, including projections oriented relative to pylons, and associated systems and methods

    Science.gov (United States)

    Mengle, Vinod G. (Inventor); Thomas, Russell H. (Inventor)

    2012-01-01

    Nozzle exit configurations and associated systems and methods are disclosed. An aircraft system in accordance with one embodiment includes a jet engine exhaust nozzle having an internal flow surface and an exit aperture, with the exit aperture having a perimeter that includes multiple projections extending in an aft direction. Aft portions of individual neighboring projections are spaced apart from each other by a gap, and a geometric feature of the multiple can change in a monotonic manner along at least a portion of the perimeter. Projections near a support pylon and/or associated heat shield can have particular configurations, including greater flow immersion than other projections.

  8. The association between obesity, cardiometabolic disease biomarkers, and innate immunity-related inflammation in Canadian adults

    Directory of Open Access Journals (Sweden)

    Da Costa LA

    2012-10-01

    Full Text Available Laura A Da Costa,1,2,*Paul Arora,2,3,* Bibiana García-Bailo,1,2 Mohamed Karmali,1,2 Ahmed El-Sohemy,1 Alaa Badawi2 1Department of Nutritional Sciences, University of Toronto; 2Office of Biotechnology and Population Health, Public Health Agency of Canada; 3Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada *These authors contributed equally to this article Introduction: Obesity is associated with a state of chronic inflammation, and increased cardiometabolic disease risk. The present study examined the relationship between body mass index (BMI and cardiometabolic and inflammatory biomarkers among normal weight, overweight, and obese Canadian adults.Methods: Subjects (n = 1805, aged 18 to 79 years from the Canadian Health Measures Survey (CHMS were examined for associations between BMI, cardiometabolic markers (apolipoprotein [Apo] A1, ApoB, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], total cholesterol, total cholesterol/HDL ratio [total:HDL-C ratio], triglycerides, and glycosylated hemoglobin [HbA1c], inflammatory factors (C-reactive protein [CRP], fibrinogen, and homocysteine, and 25-hydroxyvitamin D [25(OHD]. Bootstrap weights for variance and sampling weights for point estimates were applied to account for the complex survey design. Linear regression models adjusted for age, sex, physical activity, smoking status, and ethnicity (in addition to season of clinic visit, for vitamin D analyses only were used to examine the association between cardiometabolic markers, inflammatory factors, and BMI in Canadian adults.Results: All biomarkers were significantly associated with BMI (P ≤ 0.001. ApoA1 (β = −0.31, P < 0.0001, HDL-C (β = −0.61, P < 0.0001, and 25(OHD (β = −0.25, P < 0.0001 were inversely associated with BMI, while all other biomarkers showed positive linear associations. Distinct patterns of association were noted among normal weight, overweight

  9. Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects

    OpenAIRE

    Eleonora Poggiogalle; Carla Lubrano; Lucio Gnessi; Stefania Mariani; Andrea Lenzi; Lorenzo Maria Donini

    2016-01-01

    Introduction Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. Methods 427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI)

  10. Revisiting Mednick's Model on Creativity-Related Differences in Associative Hierarchies. Evidence for a Common Path to Uncommon Thought.

    Science.gov (United States)

    Benedek, Mathias; Neubauer, Aljoscha C

    2013-12-01

    Fifty years ago, Mednick [Psychological Review, 69 (1962) 220] proposed an elaborate model that aimed to explain how creative ideas are generated and why creative people are more likely to have creative ideas. The model assumes that creative people have flatter associative hierarchies and as a consequence can more fluently retrieve remote associative elements, which can be combined to form creative ideas. This study aimed at revisiting Mednick's model and providing an extensive test of its hypotheses. A continuous free association task was employed and association performance was compared between groups high and low in creativity, as defined by divergent thinking ability and self-report measures. We found that associative hierarchies do not differ between low and high creative people, but creative people showed higher associative fluency and more uncommon responses. This suggests that creativity may not be related to a special organization of associative memory, but rather to a more effective way of accessing its contents. The findings add to the evidence associating creativity with highly adaptive executive functioning. PMID:24532853

  11. Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring

    Institute of Scientific and Technical Information of China (English)

    Yao-hua KE; Chun WANG; Yun-qiu HU; Miao LI; Yu-juan LIU; Wen-zhen FU; Zhen-lin ZHANG; Wen-jin XIAO; Jin-wei HE; Hao ZHANG; Jin-bo YU; Wei-wei HU; Jie-mei GU; Gao GAO; Hua YUE

    2012-01-01

    Aim:Genetic variation in ALOX12,which encoded human 12-lipoxygenase,was found to be associated with fat mass in young Chinese men.The objective of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) and haplotypes in the ALOX15 gene and obesity-related phenotypes in Chinese nuclear families with male offspring.Methods:We recruited 1,296 subjects from 427 nuclear families with male offspring and genotyped five SNPs (rs9894225,rs748694,rs2619112,rs2619118,and rs916055) in the ALOX15 gene locus.The total fat mass (TFM),trunk fat mass (tFM),leg fat mass (LFM) and arm fat mass (AFM) were measured using dual-energy X-ray absorptiometry (DXA).The percentage of fat mass (PFM) was the ratio of TFM and body weight.The association between SNPs and haplotypes of ALOX15 and obesity-related phenotypic variation was measured using quantitative transmission disequilibrium test (QTDT).Results:Using QTDT to measure family-based genetic association,we found that rs916055 had a statistically significant association with PFM (P=0.038),whereas rs916055 had a marginal but statistically insignificant association with tFM (P=0.093).The multipleparameter 1000 permutations test agreed with the family-based association results:both showed that rs916055 had a statistically significant association with PFM (P=0.033).Conclusion:rs916055 in ALOX15 gene was significantly associated with the percentage of fat mass in Chinese nuclear families with male offspring in the family-based association study using QTDT approach.

  12. Relational Factors Associated with Depressive Symptoms among Stroke Survivor-Spouse Dyads

    Science.gov (United States)

    McCarthy, Michael J.; Lyons, Karen S.; Powers, Laurie E.

    2012-01-01

    Depression following stroke is a major problem for survivors and spouses, but few studies have focused on the experiences of couples. This study investigates associations between perceived relationship quality, communication and coping patterns, interpersonal misunderstandings and expectations, and survivors' and spouses' depressive symptoms after…

  13. Inhibitory Control and Empathy-Related Personality Traits: Sex-Linked Associations

    Science.gov (United States)

    Hansen, Stefan

    2011-01-01

    We here report two studies exploring associations between inhibitory control (measured with the Sustained Attention to Response Task, SART) on the one hand, and self-reports of trait cooperativeness and empathy on the other. A coherent picture was obtained in women whose inhibitory control proficiency predicted higher scores on the Temperament and…

  14. Tobacco industry influence on the definition of tobacco related disorders by the American Psychiatric Association

    OpenAIRE

    Neuman, M; Bitton, A; Glantz, S

    2005-01-01

    Objective: The Diagnostic and statistical manual of mental disorders, third edition (DSM-III), published by the American Psychiatric Association (APA) in 1980, included the first official definitions by the APA of tobacco dependence and tobacco withdrawal. Tobacco industry efforts to influence the DSM-III were investigated.

  15. Correlates of Attitudes toward Cohabitation: Looking at the Associations with Demographics, Relational Attitudes, and Dating Behavior

    Science.gov (United States)

    Willoughby, Brian J.; Carroll, Jason S.

    2012-01-01

    The present study examines how demographics, attitudes toward marriage, attitudes toward sexual activity, sexual behaviors, and dating experience are associated with three different attitudes toward cohabitation among never-married young adults. Results from a sample of 1,036 young adult college students suggest that the endorsement of…

  16. Systemic lupus erythematosus in association with ulcerative colitis: related autoimmune diseases.

    Science.gov (United States)

    Stevens, H P; Ostlere, L S; Rustin, M H

    1994-03-01

    We report a patient who developed urticaria, angio-oedema and polyarthropathy secondary to the hypocomplementaemic urticarial vasculitis syndrome, a year prior to the onset of ulcerative colitis. Ten years later, primary sclerosing cholangitis and the antiphospholipid syndrome developed concomitantly. We believe this patient represents only the second reported case of idiopathic systemic lupus erythematosus (SLE) occurring in association with ulcerative colitis. PMID:8148283

  17. Biographic and behavioral factors are associated with music-related motor skills in children pianists.

    Science.gov (United States)

    Spector, June T; Yong, Raymond; Altenmüller, Eckart; Jabusch, Hans-Christian

    2014-10-01

    This study aimed to identify biographical and behavioral factors associated with children pianists' motor skills using an objective assessment of a music-relevant motor task. Motor skills at the piano were assessed in 30 children pianists by measuring temporal unevenness in standardized scale playing using musical instrument digital interface (MIDI)-based scale analysis. Questionnaires were used to collect detailed information about the amount of time playing the piano, practice characteristics, attitudes toward music and practice, and the environment of music and practice. Associations between performance values and variables from the questionnaire were investigated using multivariable linear regression. A higher number of years playing the piano, more frequent parental involvement in the child's practice, more frequent practice of technical exercises, and greater enjoyment of practice and of the visual arts were associated with better motor performance. In addition to cumulative experience and aspects of practice, extrinsic motivational factors (e.g., parental interest) and intrinsic motivational factors (e.g., an artistic disposition) were associated with better performance on a musically-relevant motor task in children pianists. PMID:25215624

  18. Association of MC4R variants with obesity-related traits in Hispanic children

    Science.gov (United States)

    Melanocortin 4 receptor (MC4R) has been implicated in the regulation of appetite and energy expenditure. In children, MC4R mutations have been associated with severe obesity. The main objective of this study was to investigate the potential functional effects of variants in MC4R gene on the variatio...

  19. Structural Changes after Videogame Practice Related to a Brain Network Associated with Intelligence

    Science.gov (United States)

    Colom, Roberto; Quiroga, Ma. Angeles; Solana, Ana Beatriz; Burgaleta, Miguel; Roman, Francisco J.; Privado, Jesus; Escorial, Sergio; Martinez, Kenia; Alvarez-Linera, Juan; Alfayate, Eva; Garcia, Felipe; Lepage, Claude; Hernandez-Tamames, Juan Antonio; Karama, Sherif

    2012-01-01

    Here gray and white matter changes after four weeks of videogame practice were analyzed using optimized voxel-based morphometry (VBM), cortical surface and cortical thickness indices, and white matter integrity computed from several projection, commissural, and association tracts relevant to cognition. Beginning with a sample of one hundred young…

  20. Giant hepatic artery aneurysm associated with immunoglobulin G4-related disease successfully treated using a liquid embolic agent

    International Nuclear Information System (INIS)

    The occurrence of a giant hepatic artery aneurysm (GHAA) in a patient with systemic vasculitis is very rare. Herein, we describe our endovascular treatment experience of a GHAA associated with immunoglobulin G4-related disease (IgG4-RD) consisting primarily of a liquid embolic injection and deployment of a vascular plug

  1. Seasonality and physician-related factors associated with antibiotic prescribing: A cross-sectional study in Isfahan, Iran

    Directory of Open Access Journals (Sweden)

    Leila Safaeian

    2015-01-01

    Conclusions: These findings showed the widespread use of antibiotics by general practitioners that was associated with the physicians′ gender, time since graduation and practice location and also season of prescribing. More researches are needed on other factors related to the overprescribing of antibiotics and they could be used to project educational programs for improvement of antibiotic prescribing quality in our country.

  2. Recess physical activity and school-related social factors in Finnish primary and lower secondary schools : cross-sectional associations

    OpenAIRE

    Haapala, Henna L; Hirvensalo, Mirja H; Laine, Kaarlo; Laakso, Lauri; Hakonen, Harto; Kankaanpää, Anna; Lintunen, Taru; Tammelin, Tuija H

    2014-01-01

    Abstract Background Participation in physical activities provides students with opportunities for social interaction and social skills development. The purpose of this study was to investigate the associations of students’ recess physical activity with school-related social factors. Methods Data were collected in 19 schools countrywide in autumn 2010, and 1463 students from grades 4 and 5 (primary school...

  3. School Public Relations and the Principalship: An Interview with Mark Bielang, President of American Association of School Administrators

    Science.gov (United States)

    Johnson, Paul

    2011-01-01

    From returning phone calls to traversing the political landscape to building trust, American Association of School Administrators (AASA) president Mark Bielang covers a lot of territory as he describes the public relations challenges confronting today's school administrators. Having just concluded his term as AASA president, Mr. Bielang has served…

  4. An Indirect Effects Model of the Association between Poverty and Child Functioning: The Role of Children's Poverty-Related Stress

    Science.gov (United States)

    Wadsworth, Martha E.; Raviv, Tali; Reinhard, Christine; Wolff, Brian; Santiago, Catherine DeCarlo; Einhorn, Lindsey

    2008-01-01

    The authors tested a theoretical model positing that poverty has an indirect effect on child and adolescent functioning through children's poverty-related stress. Path analyses with a multiethnic sample of 164 children aged 6 to 18 revealed that the stress associated with poverty, such as economic strain, family conflict, violence/trauma, and…

  5. Differential-Associative Processing or Example Elaboration: Which Strategy Is Best for Learning the Definitions of Related and Unrelated Concepts?

    Science.gov (United States)

    Hannon, Brenda

    2012-01-01

    Definitions of related concepts (e.g., "genotype-phenotype") are prevalent in introductory classes. Consequently, it is important that educators and students know which strategy(s) work best for learning them. This study showed that a new comparative elaboration strategy, called differential-associative processing, was better for learning…

  6. Associations between School-Related Factors and Depressive Symptoms among Children: A Comparative Study, Finland and Norway

    Science.gov (United States)

    Minkkinen, Jaana

    2014-01-01

    This study compares school-related associations in depressive symptoms among children aged between 9-13 years from four schools in Finland and Norway. A total of 523 pupils participated in the cross-sectional survey. The connections between depressive symptoms and school factors were analysed using hierarchical regression analyses. School…

  7. Complexities in understanding the role of compensation-related factors on recovery from whiplash-associated disorders : discussion paper 2

    NARCIS (Netherlands)

    Carroll, Linda J.; Connelly, Luke B.; Spearing, Natalie M.; Cote, Pierre; Buitenhuis, Jan; Kenardy, Justin

    2011-01-01

    Study Design. Focused discussion. Objective. To present some of the complexities in conducting research on the role of compensation and compensation-related factors in recovery from whiplash-associated disorders (WAD) and to suggest directions for future research. Summary of Background Data. There i

  8. Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration.

    NARCIS (Netherlands)

    Smailhodzic, D.; Klaver, C.C.; Klevering, B.J.; Boon, C.J.F.; Groenewoud, J.M.M.; Kirchhof, B.; Daha, M.R.; Hollander, A.I. den; Hoyng, C.B.

    2012-01-01

    PURPOSE: Systemic complement activation is associated with age-related macular degeneration (AMD) and has mainly been attributed to a risk allele in the complement factor H (CFH) gene. Whether other important AMD genes also influence complement activation is unclear. In the present case-control stud

  9. Giant hepatic artery aneurysm associated with immunoglobulin G4-related disease successfully treated using a liquid embolic agent

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Michele; Virgilio, Edoardo; Laurino, Florindo; Orgera, Gianluigi; Mene, Paolo; Pirozzi, Nicola; Ziparo, Vincenzo; Cavallini, Marco [St. Andrea Hospital, Rome (Italy)

    2015-08-15

    The occurrence of a giant hepatic artery aneurysm (GHAA) in a patient with systemic vasculitis is very rare. Herein, we describe our endovascular treatment experience of a GHAA associated with immunoglobulin G4-related disease (IgG4-RD) consisting primarily of a liquid embolic injection and deployment of a vascular plug.

  10. Associations between Sadness and Anger Regulation Coping, Emotional Expression, and Physical and Relational Aggression among Urban Adolescents

    Science.gov (United States)

    Sullivan, Terri N.; Helms, Sarah W.; Kliewer, Wendy; Goodman, Kimberly L.

    2010-01-01

    This study examined associations between self-reports of sadness and anger regulation coping, reluctance to express emotion, and physical and relational aggression between two cohorts of predominantly African-American fifth (N = 191; 93 boys and 98 girls) and eighth (N = 167; 73 boys and 94 girls) graders. Multiple regression analyses indicated…

  11. Cultural, social and intrapersonal factors associated with clusters of co-occurring health-related behaviours among adolescents

    NARCIS (Netherlands)

    Klein Velderman, Mariska; Dusseldorp, Elise; van Nieuwenhuijzen, Maroesjka; Junger, Marianne; Paulussen, Theo G. W. M.; Reijneveld, Sijmen A.

    2015-01-01

    BACKGROUND: Adverse health-related behaviours (HRBs) have been shown to co-occur in adolescents. Evidence lacks on factors associated with these co-occurring HRBs. The Theory of Triadic Influence (TTI) offers a route to categorize these determinants according to type (social, cultural and intraperso

  12. Dietary patterns of adolescents in Germany - Associations with nutrient intake and other health related lifestyle characteristics

    Directory of Open Access Journals (Sweden)

    Richter Almut

    2012-03-01

    Full Text Available Abstract Background The aim of this study was to identify dietary patterns among a representative sample of German adolescents and their associations with energy and nutrient intake, socioeconomic and lifestyle characteristics, and overweight status. Methods In the analysis, data from the German Health Interview and Examination Survey for Children and Adolescents were used. The survey included a comprehensive dietary history interview conducted among 1272 adolescents aged 12 to 17 years. Dietary patterns were determined with principal component analysis (PCA based on 48 food groups, for boys and girls separately. Results Three dietary patterns among boys and two among girls were identified. Among boys, high adherence to the 'western' pattern was associated with higher age, lower socioeconomic status (SES, and lower physical activity level (PA. High adherence to the 'healthy' pattern among boys, but not among girls, was associated with higher SES, and higher PA. Among boys, high adherence to the 'traditional' pattern was associated with higher age. Among girls, high adherence to the 'traditional and western' pattern was associated with lower age, lower SES and more hours watching TV per day. The nutrient density of several vitamins and minerals, particularly of B-vitamins and calcium, increased with increasing scores of the 'healthy' pattern among both sexes. Conversely, with increasing scores of the 'western' pattern among boys, most nutrient densities decreased, particularly of fibre, beta-carotene, vitamin D, biotin and calcium. Among girls with higher scores of the 'traditional and western' pattern, nutrient densities of vitamin A, C, E, K and folate decreased. Among boys, high adherence to the 'traditional' pattern was correlated with higher densities of vitamin B12 and vitamin D and lower densities of fibre, magnesium and iron. No significant associations between dietary patterns and overweight were found. Conclusions Higher scores for

  13. Illness representations of type 2 diabetes patients are associated with perceptions of diabetes threat in relatives.

    Science.gov (United States)

    van Esch, Suzanne C M; Nijkamp, Marjan D; Cornel, Martina C; Snoek, Frank J

    2014-03-01

    In the fight against the type 2 diabetes epidemic, patients might be asked to discuss familial susceptibility to type 2 diabetes in their family. Illness representations of patients (N = 546) were assessed to explore their impact on perceived type 2 diabetes threat in relatives. Reporting high type 2 diabetes burden, emotional impact and perceiving type 2 diabetes as an inheritable disease seemed to increase patients' family risk perception and worries about relatives' future health. Patients with coherent illness understanding reported positive beliefs regarding type 2 diabetes prevention in relatives. Findings may give direction in how illness representations may be used to guide patients in the process of family risk disclosure. PMID:23399919

  14. Are recurrent denture-related sores associated with the risk of oral cancer? A case control study

    Directory of Open Access Journals (Sweden)

    Ligia Drovandi Braga Rotundo

    2013-09-01

    Full Text Available Objectives: This study aimed to assess the hypothesis that recurrent denture-related sores association may be associated with the risk of oral cancer. Methods: We conducted a hospital-based case-control study comprising 71 new cases of oral cancer in two hospitals in São Paulo, Brazil, and 240 controls without cancer, recruited from outpatient units of the same hospitals. All cases had histologically confirmed squamous cell carcinoma in anatomic sites of the mouth that may be specifically consi-dered at risk of sores by ill-fitting dentures. Denture-related sores were assessed by the self-report of recurrent oral sores due to the use of ill-fitting complete removable dental prosthesis. Associations were assessed by multivariate logistic regression conditioned on socio-demographic and behavioral characteristics. Results: The association between ill-fitting dentures and oral cancer was statistically significant in the multivariate model: odds ratio 3.98; 95% confidence interval 1.06 - 14.96. The specific assessment of association between tumors in the lower jaw and sores by mandibular dentures confirmed this result: odds ratio 6.39; 95% confidence interval 1.49 - 29.52. Conclusion: The potential contribution of denture-related sores to oral carcinogenesis still fuels controversies. This study reinfor-ces the hypothesis that recurrent denture-related sores may be associated with the risk of oral cancer. Results reported here also suggest that an appropriate application and monitoring of dental prosthesis represent a non-negligible scope for cancer prevention.

  15. Increased Event-Related Potentials and Alpha-, Beta-, and Gamma-Activity Associated with Intentional Actions

    OpenAIRE

    Karch, Susanne; Loy, Fabian; Krause, Daniela; Schwarz, Sandra; Kiesewetter, Jan; Segmiller, Felix; Chrobok, Agnieszka I.; Keeser, Daniel; Pogarell, Oliver

    2016-01-01

    Objective: Internally guided actions are defined as being purposeful, self-generated and offering choices between alternatives. Intentional actions are essential to reach individual goals. In previous empirical studies, internally guided actions were predominantly related to functional responses in frontal and parietal areas. The aim of the present study was to distinguish event-related potentials and oscillatory responses of intentional actions and externally guided actions. In addition, we ...

  16. Relative acidic compartment volume as a lysosomal storage disorder–associated biomarker

    OpenAIRE

    te Vruchte, Danielle; Speak, Anneliese O; Wallom, Kerri L.; Al Eisa, Nada; Smith, David A.; Hendriksz, Christian J.; Simmons, Louise; Lachmann, Robin H.; Cousins, Alison; Hartung, Ralf; Mengel, Eugen; Runz, Heiko; Beck, Michael; Amraoui, Yasmina; Imrie, Jackie

    2014-01-01

    Lysosomal storage disorders (LSDs) occur at a frequency of 1 in every 5,000 live births and are a common cause of pediatric neurodegenerative disease. The relatively small number of patients with LSDs and lack of validated biomarkers are substantial challenges for clinical trial design. Here, we evaluated the use of a commercially available fluorescent probe, Lysotracker, that can be used to measure the relative acidic compartment volume of circulating B cells as a potentially universal bioma...

  17. Stress-dilatancy Relation for Mohr-Coulomb Soils Following a Non-Associated Flow Rule

    OpenAIRE

    Zhang, J.; Salgado, Rodrigo

    2010-01-01

    Rowe's stress–dilatancy relation for frictional (cohesionless) materials has been a cornerstone of soil mechanics. The original derivation of this relationship was based on incorrect energy minimisation considerations, but the relationship was proven later by De Josselin de Jong using friction laws, and has been confirmed by a large body of experimental results. In contrast, the validity of Rowe's stress–dilatancy relation for cohesive-frictional materials, which has also been used, although ...

  18. Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study

    Directory of Open Access Journals (Sweden)

    Yaegashi Nobuo

    2010-06-01

    Full Text Available Abstract Background Diet is considered an important factor for bone health, but is composed of a wide variety of foods containing complex combinations of nutrients. Therefore we investigated the relationship between dietary patterns and fall-related fractures in the elderly. Methods We designed a population-based prospective survey of 1178 elderly people in Japan in 2002. Dietary intake was assessed with a 75-item food frequency questionnaire (FFQ, from which dietary patterns were created by factor analysis from 27 food groups. The frequency of fall-related fracture was investigated based on insurance claim records from 2002 until 2006. The relationship between the incidence of fall-related fracture and modifiable factors, including dietary patterns, were examined. The Cox proportional hazards regression model was used to examine the relationships between dietary patterns and incidence of fall-related fracture with adjustment for age, gender, Body Mass Index (BMI and energy intake. Results Among 877 participants who agreed to a 4 year follow-up, 28 suffered from a fall-related fracture. Three dietary patterns were identified: mainly vegetable, mainly meat and mainly traditional Japanese. The moderately confirmed (see statistical methods groups with a Meat pattern showed a reduced risk of fall-related fracture (Hazard ratio = 0.36, 95% CI = 0.13 - 0.94 after adjustment for age, gender, BMI and energy intake. The Vegetable pattern showed a significant risk increase (Hazard ratio = 2.67, 95% CI = 1.03 - 6.90 after adjustment for age, gender and BMI. The Traditional Japanese pattern had no relationship to the risk of fall-related fracture. Conclusions The results of this study have the potential to reduce fall-related fracture risk in elderly Japanese. The results should be interpreted in light of the overall low meat intake of the Japanese population.

  19. Association between Traffic-Related Black Carbon Exposure and Lung Function among Urban Women

    OpenAIRE

    Suglia, Shakira Franco; Gryparis, Alexandros; Schwartz, Joel David; Wright, Rosalind Jo

    2008-01-01

    Background: Although a number of studies have documented the relationship between lung function and traffic-related pollution among children, few have focused on adult lung function or examined community-based populations. Objective: We examined the relationship between black carbon (BC), a surrogate of traffic-related particles, and lung function among women in the Maternal–Infant Smoking Study of East Boston, an urban cohort in Boston, Massachusetts. Methods: We estimated local BC levels us...

  20. Association between diabetes-related factors and clinical periodontal parameters in type-2 diabetes mellitus

    OpenAIRE

    Kim, Eun-Kyong; Lee, Sang Gyu; CHOI Youn-Hee; Won, Kyu-Chang; Moon, Jun Sung; Merchant, Anwar T.; Lee, Hee-Kyung

    2013-01-01

    Background Evidence consistently shows that diabetes is a risk factor for increased prevalence of gingivitis and periodontitis. But there is a controversy about the relationship between diabetes related factors and periodontal health. The aim of the present study is to explore the relationship between diabetes related factors such as glycosylated hemoglobin, fasting blood glucose, duration of diabetes and compliance to diabetes self management and periodontal health status. Methods Periodonta...

  1. Association between work-related health problems and job insecurity in permanent and temporary employees

    OpenAIRE

    Lee, Won-Wook; Park, Jae-Bum; Min, Kyoung-Bok; Lee, Kyung-Jong; Kim, Min-Su

    2013-01-01

    Objectives This research was conducted with an aim of determining the correlation between job insecurity and an employee’s work-related health problems among permanent and temporary workers. Methods Using the data from the First Korean Working Conditions Survey conducted in 2006, a total of 7,071 workers, excluding employers and the self-employed, were analyzed. Work-related health problems were categorized as backache, headache, abdominal pain, muscular pain, stress, fatigue, insomnia, anxie...

  2. Associations of Social Anxiety and Depression with Cognitions Related to Problematic Internet Use in Youths

    OpenAIRE

    Durak, Mithat; Abant Izzet Baysal University; Şenol Durak, Emre; Abant İzzet Baysal Üniversitesi

    2013-01-01

    Presence of psychopathology (e.g., depression and anxiety) has found to be related to an increased vulnerability to develop problematic Internet use (PIU). The current study aimed to investigate the effects of social anxiety and depression on cognitions related to PIU based on a cognitive behavioral framework in youths. The Online Cognition Scale (OCS), The Beck Depression Inventory (BDI), The Liebowitz Social Anxiety Scale (LSAS) and Demographic Information Form were administered and hierarc...

  3. Association between Cancer Literacy and Cancer-Related Behaviour: Evidence from Ticino, Switzerland

    OpenAIRE

    Nicola Diviani; Schulz, Peter J

    2014-01-01

    Background This paper details the role of different dimensions of health literacy in the relationship between health literacy and cancer-related health behaviours. In particular, Cancer Literacy is studied as an exemplar of a dimension of health literacy beyond basic reading and writing skills. The link between functional health literacy, Cancer Literacy and cancer-related health behaviours is investigated in a sample of Ticino (Switzerland) residents (n=639). Design and methods Detailed data...

  4. Taking cognizance of mental illness in schizophrenics and its association with crime and substance-related diagnoses

    DEFF Research Database (Denmark)

    Munkner, R; Haastrup, S; Jørgensen, T;

    2003-01-01

    OBJECTIVE: To analyse how committed crimes and substance-related diagnoses are associated with the age on the first contact with the psychiatric hospital system and the age at diagnosing of schizophrenia among schizophrenics. METHOD: In a register-based study including all Danes diagnosed with...... diagnosis of schizophrenia was first given. In contrast, having a substance-related diagnosis was associated with a younger age on first contact but did not influence the age at which the diagnosis of schizophrenia was given. CONCLUSION: It is important that both psychiatrists and the judicial system are...... schizophrenia born after November 1, 1963, data on criminality, substance-related diagnoses and contacts with the psychiatric hospital system were analysed. RESULTS: Compared with the non-convicted schizophrenics the convicted were older on first contact with the psychiatric hospital system and older when the...

  5. Body checking and avoidance in women: associations with mental and physical health-related quality of life.

    Science.gov (United States)

    Latner, Janet D; Mond, Jonathan M; Vallance, Joanna K; Gleaves, David H; Buckett, Geoffrey

    2012-12-01

    Body checking and body avoidance have demonstrated clinical significance in a number of populations. However, the associations between these behaviors and mental and physical health-related quality of life have not been examined. This study investigated the associations between body checking and avoidance and quality of life in 214 community women. Body checking and body avoidance were significantly correlated with mental and physical quality of life, as well as with eating disturbances. Frequency of body checking significantly predicted impairment in mental quality of life, and frequency of body avoidance significantly predicted impairment in physical quality of life, over and above the contributions of depressive symptoms and related demographic characteristics. Targeting checking and avoidance in prevention and treatment programs may improve quality of life and reduce health-related functional impairment. PMID:23121794

  6. Taking cognizance of mental illness in schizophrenics and its association with crime and substance-related diagnoses

    DEFF Research Database (Denmark)

    Munkner, R; Haastrup, S; Jørgensen, T; Andreasen, A H; Kramp, P

    2003-01-01

    OBJECTIVE: To analyse how committed crimes and substance-related diagnoses are associated with the age on the first contact with the psychiatric hospital system and the age at diagnosing of schizophrenia among schizophrenics. METHOD: In a register-based study including all Danes diagnosed with...... schizophrenia born after November 1, 1963, data on criminality, substance-related diagnoses and contacts with the psychiatric hospital system were analysed. RESULTS: Compared with the non-convicted schizophrenics the convicted were older on first contact with the psychiatric hospital system and older when the...... diagnosis of schizophrenia was first given. In contrast, having a substance-related diagnosis was associated with a younger age on first contact but did not influence the age at which the diagnosis of schizophrenia was given. CONCLUSION: It is important that both psychiatrists and the judicial system are...

  7. Assessing brain structural associations with working memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis

    Directory of Open Access Journals (Sweden)

    Christine Lycke Brandt

    2015-01-01

    Full Text Available Schizophrenia (SZ is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural cortical and subcortical brain abnormalities have been documented, but little is known about how task-related brain activation is associated with brain anatomy in SZ compared to healthy controls (HC. Utilizing linked independent component analysis (LICA, a data-driven multimodal analysis approach, we investigated structure–function associations in a large sample of SZ (n = 96 and HC (n = 142. We tested for associations between task-positive (fronto-parietal and task-negative (default-mode brain networks derived from fMRI activation during an n-back working memory task, and brain structural measures of surface area, cortical thickness, and gray matter volume, and to what extent these associations differed in SZ compared to HC. A significant association (p < .05, corrected for multiple comparisons was found between a component reflecting the task-positive fronto-parietal network and another component reflecting cortical thickness in fronto-temporal brain regions in SZ, indicating increased activation with increased thickness. Other structure–function associations across, between and within groups were generally moderate and significant at a nominal p-level only, with more numerous and stronger associations in SZ compared to HC. These results indicate a complex pattern of moderate associations between brain activation during cognitive processing and brain morphometry, and extend previous findings of fronto-temporal brain abnormalities in SZ by suggesting a coupling between cortical thickness of these brain regions and working memory-related brain activation.

  8. Rhodococcus bacteremia in cancer patients is mostly catheter related and associated with biofilm formation.

    Directory of Open Access Journals (Sweden)

    Fadi Al Akhrass

    Full Text Available Rhodococcus is an emerging cause of opportunistic infection in immunocompromised patients, most commonly causing cavitary pneumonia. It has rarely been reported as a cause of isolated bacteremia. However, the relationship between bacteremia and central venous catheter is unknown. Between 2002 and 2010, the characteristics and outcomes of seventeen cancer patients with Rhodococcus bacteremia and indwelling central venous catheters were evaluated. Rhodococcus bacteremias were for the most part (94% central line-associated bloodstream infection (CLABSI. Most of the bacteremia isolates were Rhodococcus equi (82%. Rhodococcus isolates formed heavy microbial biofilm on the surface of polyurethane catheters, which was reduced completely or partially by antimicrobial lock solution. All CLABSI patients had successful response to catheter removal and antimicrobial therapy. Rhodococcus species should be added to the list of biofilm forming organisms in immunocompromised hosts and most of the Rhodococcus bacteremias in cancer patients are central line associated.

  9. Extraction and partial purification of chitinase from mycosymbiont and its relation with mycorrhiza association process

    International Nuclear Information System (INIS)

    Extraction effectivity and partial purification of chitinase extracellular metabolite from Scleroderma columnare, Pisolithus tinctorius, Trichoderma harzianum and the root of Shorea selanica have been searched. S. columnare and P. tinctorius were the mycosymbiont for S. selanica while T. harzianum was not. (NH4)2SO4 was the very effective solvent for crude extracellular enzyme extraction, followed by PEG-6000 and ethanol 50 percent respectively. The activity of P. tinctorius was the lowest among the microbe while S. columnare was the highest. The activity lowered by purification process but specific activity was not. The chitinase activity of inoculated root was higher in the S. columnare association than P. tinctorius's also the percentage of root chitin content and infection rate. It mean that S. columnare more effective as mycosymbiont. The periods of association lowered the activity of root chitinase but this phenomenon did not happen in the root of S. selanica with T. harzianum infection

  10. Participation in voluntary associations: relations with resources, personality, and political values

    OpenAIRE

    Bekkers, René

    2005-01-01

    Participation in voluntary associations is explained by different theories in sociology, psychology and political science. Sociologists have emphasized the effects of resources such as human and social capital. Psychologists have demonstrated the role of empathy and extraversion as aspects of personality. Political scientists have considered political values and attitudes. This paper investigates the predictive value of personality characteristics, political values and social conditions for c...

  11. A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis

    OpenAIRE

    Bossini-Castillo, L.; Simeon, C. P.; Beretta, L; Broen, J.C.A.; Vonk, M.C.; Rios-Fernandez, R.; Espinosa, G.; Carreira, P; Camps, M T; Castillo, M.J.; Gonzalez-Gay, M A; Beltran, E.; Carmen Freire, M.; Narvaez, J; Tolosa, C

    2012-01-01

    Abstract Introduction CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population. Methods A total of seven European populations of Caucasian ancestry were included, comprising 2,131 patients with SSc and 3,966 healthy controls. Three CD226 single nucleotide p...

  12. Relation of the Allelic Variants of Multidrug Resistance Gene to Agranulocytosis Associated With Clozapine.

    Science.gov (United States)

    Anil Yağcioğlu, A Elif; Yoca, Gökhan; Ayhan, Yavuz; Karaca, R Özgür; Çevik, Lokman; Müderrisoğlu, Ahmet; Göktaş, Mustafa T; Eni, Nurhayat; Yazici, M Kâzim; Bozkurt, Atilla; Babaoğlu, Melih O

    2016-06-01

    Clozapine use is associated with leukopenia and more rarely agranulocytosis, which may be lethal. The drug and its metabolites are proposed to interact with the multidrug resistance transporter (ABCB1/MDR1) gene product, P-glycoprotein (P-gp). Among various P-glycoprotein genetic polymorphisms, nucleotide changes in exons 26 (C3435T), 21 (G2677T), and 12 (C1236T) have been implicated for changes in pharmacokinetics and pharmacodynamics of many substrate drugs. In this study, we aimed to investigate the association between these specific ABCB1 polymorphisms and clozapine-associated agranulocytosis (CAA). Ten patients with a history of CAA and 91 control patients without a history of CAA, despite 10 years of continuous clozapine use, were included. Patient recruitment and blood sample collection were conducted at the Hacettepe University Faculty of Medicine, Department of Psychiatry, in collaboration with the members of the Schizophrenia and Other Psychotic Disorders Section of the Psychiatric Association of Turkey, working in various psychiatry clinics. After DNA extraction from peripheral blood lymphocytes, genotyping was performed using polymerase chain reaction and endonuclease digestion. Patients with CAA had shorter duration of clozapine use but did not show any significant difference in other clinical, sociodemographic characteristics and in genotypic or allelic distributions of ABCB1 variants and haplotypes compared with control patients. Among the 10 patients with CAA, none carried the ABCB1 all-variant haplotype (TT-TT-TT), whereas the frequency of this haplotype was approximately 12% among the controls. Larger sample size studies and thorough genetic analyses may reveal both genetic risk and protective factors for this serious adverse event. PMID:27043126

  13. The associations between psychosocial aspects and TMD-pain related aspects in children and adolescents

    OpenAIRE

    Al-Khotani, Amal; Naimi-Akbar, Aron; Gjelset, Mattias; Albadawi, Emad; Bello, Lanre; Hedenberg-Magnusson, Britt; Christidis, Nikolaos

    2016-01-01

    Background Temporomandibular disorders (TMD) in children and adolescents is prevalent with pain as a common component, and has a comorbidity with psychosocial problems such as stress, depression, anxiety as well as somatic complaints. Therefore, the aim of the study was to investigate if psychosocial problems in children and adolescents are associated with TMD with pain (TMD-pain) and TMD without pain (TMD-painfree) when compared to children and adolescents without TMD. Methods This cross-sec...

  14. Genome-Wide Association Analysis of Eating Disorder-Related Symptoms, Behaviors, and Personality Traits

    OpenAIRE

    Boraska, Vesna; Davis, Oliver SP; Cherkas, Lynn F; Helder, Sietske G; Harris, Juliette; Krug, Isabel; Pei-Chi Liao, Thomas; Treasure, Janet; Ntalla, Ioanna; Karhunen, Leila; Keski-Rahkonen, Anna; Christakopoulou, Danai; Raevuori, Anu; Shin, So-Youn; Dedoussis, George V.

    2012-01-01

    Eating disorders (EDs) are common, complex psychiatric disorders thought to be caused by both genetic and environmental factors. They share many symptoms, behaviors, and personality traits, which may have overlapping heritability. The aim of the present study is to perform a genome-wide association scan (GWAS) of six ED phenotypes comprising three symptom traits from the Eating Disorders Inventory 2 [Drive for Thinness (DT), Body Dissatisfaction (BD), and Bulimia], Weight Fluctuation symptom,...

  15. ASSOCIATION BETWEEN SARCOPENIA-RELATED PHENOTYPES AND AEROBIC CAPACITY INDEXES OF OLDER WOMEN

    OpenAIRE

    Lídia Mara Aguiar Bezerra; Kaley Moura Leite; Marcelo Guido; Francisco Pitanga; Antonio Marco Mota; Martim Bottaro; Ricardo Jacó de Oliveira; Ricardo Moreno Lima

    2009-01-01

    The purpose of the present study was to examine the association between fat-free mass (FFM), quadriceps strength and sarcopenia with aerobic fitness indexes of elderly women. A total of 189 volunteers (66.7 ± 5.46 years) underwent aerobic capacity measurement through a symptom-limited cardiopulmonary exercise test to determine their individual ventilatory thresholds (VT) and peak oxygen uptake (VO2 peak). Quadriceps muscle strength was assessed using an isokinetic dynamometer. Also, dual ener...

  16. Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects.

    Directory of Open Access Journals (Sweden)

    Eleonora Poggiogalle

    Full Text Available Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status.427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM to appendicular skeletal muscle (ASM ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used.BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05. A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001 was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001, GH (r = -0.200, p = 0.006, and IGF- 1 levels (r = -0.157, p = 0.028. Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda.Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects.

  17. A Learning-Centered View of Business Associations: Building Business-Government Relations for Development

    OpenAIRE

    Perez-Aleman Paola

    2003-01-01

    The problems of rent seeking and state captured by business associations have been prominent among the concerns of economic development theory. This paper argues that firms and the state can make possible the building of new institutions that foster improvements in economic performance through arrangements that emphasize goal setting, problem solving, and continual evaluation of progress toward defined goals. The paper reviews key ideas on the learning-centered approach and builds on them to ...

  18. Structural changes after videogame practice related to a brain network associated with intelligence

    OpenAIRE

    Colom, Roberto; Quiroga, Mª Ángeles; Solana Sánchez, Ana Beatriz; Burgaleta, Miguel; Román, Francisco J.; Privado, Jesús; Escorial, Sergio; Martínez, Kenia; Alvarez Linera, Juan; Alfayate, E.; García, Felipe; Lepage, Claude; Hernández Tamames, J.A.; Karama, Sherif

    2012-01-01

    Here gray and white matter changes after four weeks of videogame practice were analyzed using optimized voxel-based morphometry (VBM), cortical surface and cortical thickness indices, and white matter integrity computed from several projection, commissural, and association tracts relevant to cognition. Beginning with a sample of one hundred young females, twenty right handed participants were recruited for the study and assigned to a practice or a control group carefully matched by their gene...

  19. Hepatitis C virus-associated thrombocytopenia is not related to serum thrombopoietin levels

    OpenAIRE

    Afifi Ola; Sewify Eman; El-Attar Madiha; Taie Amal; Mostafa Ahmad

    2007-01-01

    Objective: Hepatitis C virus (HCV) infection is one of the most important health problems in Egypt. Thrombocytopenia is a common finding in subjects with chronic hepatitis. The precise etiology of this thrombocytopenia is still obscure. There is increasing interest in the potential role of thrombopoietin (TPO) as a cause of this thrombocytopenia. The aim of this work was to determine serum TPO levels in HCV-positive patients and to test the assumption that HCV-associated thrombocytopenia cou...

  20. Emotion-related information processing biases associated with depression in childhood

    OpenAIRE

    Drummond, Lyndsey Elizabeth

    2006-01-01

    Few studies have examined depression in children from an Information Processing (IP) perspective. In this thesis a number of domains of IP (known to be associated with adult depression)are examined in children and adolescents, in particular, autobiographical memory specificity in both clinical and non-clinical samples. Foremost, overgeneral memory (OGM) was found for the first time, to be characteristic of dysphoric (Study 1) and clinically depressed children (Study 2). Similar...

  1. A review of the adverse side effects associated with antipsychotics as related to their efficacy.

    Science.gov (United States)

    Pakpoor, Jina; Agius, Mark

    2014-11-01

    Since the introduction of antipsychotic medication for the treatment of psychosis, a wide range of different types of antipsychotic drugs have been developed while their side effects have become evident. The side effects of both the typical and atypical generation of antipsychotics have important consequences for the quality of life of recipients, stigma experienced and also the level of care of patients. It is well acknowledged that the side effects of antipsychotics reduce compliance with the medication. In this review the data for an association between typical and atypical antipsychotics and the main side effects that are well-supported in the literature was explored: weight gain and associated metabolic effects; extrapyramidal symptoms and tardive dyskinesia; prolactin elevation and associated sexual effects; QTc elongation; and a group of miscellaneous side effects. It has been demonstrated that the production of adverse effects following the use of antipsychotic medication differs widely both between atypical and typical drugs but also within these subgroups. Considering the wide range of antipsychotics available amongst both groups and the differing effects they have on patients in terms of side effects, there is reason to believe that a more personalised approach to antipsychotic treatment should be considered. Additionally, screening for risk factors, screening for the appearance of side effects, as well as good communication with patients about the side effects and other options available are important tasks for clinicians in order to optimise concordance with medication. PMID:25413553

  2. Cognitive processes associated with compulsive buying behaviours and related EEG coherence.

    Science.gov (United States)

    Lawrence, Lee Matthew; Ciorciari, Joseph; Kyrios, Michael

    2014-01-30

    The behavioural and cognitive phenomena associated with Compulsive Buying (CB) have been investigated previously but the underlying neurophysiological cognitive process has received less attention. This study specifically investigated the electrophysiology of CB associated with executive processing and cue-reactivity in order to reveal differences in neural connectivity (EEG Coherence) and distinguish it from characteristics of addiction or mood disorder. Participants (N=24, M=25.38 yrs, S.D.=7.02 yrs) completed the Sensitivity to Punishment Sensitivity to Reward Questionnaire and a visual memory task associated with shopping items. Sensitivities to reward and punishment were examined with EEG coherence measures for preferred and non-preferred items and compared to CB psychometrics. Widespread EEG coherence differences were found in numerous regions, with an apparent left shifted lateralisation for preferred and right shifted lateralisation for non-preferred items. Different neurophysiological networks presented with CB phenomena, reflecting cue reactivity and episodic memory, from increased arousal and attachment to items. PMID:24239477

  3. Patient and medication-related factors associated with hospital-acquired hyponatremia in patients hospitalized from heart failure.

    Science.gov (United States)

    Saepudin, S; Ball, Patrick A; Morrissey, Hana

    2016-08-01

    Background Hyponatremia has been known as an important predictor of clinical outcomes in patients with heart failure (HF). While information on hyponatremia in patients with HF has been available abundantly, information on factors associated with increased risk of developing hospital-acquired hyponatremia (HAH) is still limited. Objective To identify patients and medication-related factors associated with HAH in patients hospitalized from HF. Setting Fatmawati Hospital in Jakarta, Indonesia. Methods This is a nested case-control study with patients developing HAH served as case group and each patient in case group was matched by age and gender to three patients in control group. Patients included in this study are patients hospitalized from HF, and coded with I.50 according to ICD-10, during 2011-2013 at Fatmawati Hospital in Jakarta, Indonesia. Information retrieved from patients' medical records included demographic profiles, vital signs and symptoms at admission, past medical history, medication during hospitalization and clinical chemistry laboratory records. Multivariable logistic regression analysis was performed to find out patient and treatment-related factors associated with the development of HAH. Main outcome measures Patients and medication related factors having significant association with HAH. Results Four hundreds sixty-four patients were included in this study and 45 of them (9.7 %) met criteria of developing HAH so then, accordingly, 135 patients were selected as controls. 36 patient- and 22 treatment-related factors were analyzed in univariate logistic regression resulted in 20 factors having p value <0.2 and were included in multivariable logistic regression analysis. Final factors showing significant association with HAH are presence of ascites at admission (odds ratio = 4.7; 95 % confidence interval 1.9-11.5) and administration of amiodarone (3.2; 1.3-7.4) and heparin (3.1; 1.2-7.3) during hospital stay. Conclusion Presence of ascites at

  4. Relativity

    CERN Document Server

    Einstein, Albert

    2013-01-01

    Time magazine's ""Man of the Century"", Albert Einstein is the founder of modern physics and his theory of relativity is the most important scientific idea of the modern era. In this short book, Einstein explains, using the minimum of mathematical terms, the basic ideas and principles of the theory that has shaped the world we live in today. Unsurpassed by any subsequent books on relativity, this remains the most popular and useful exposition of Einstein's immense contribution to human knowledge.With a new foreword by Derek Raine.

  5. Relativity

    CERN Document Server

    Brewster, Hilary D

    2009-01-01

    The theory of relativity has become a cornerstone of modern physics. Over the course of time it has been scrutinized in a multitude of experiments and has always been verified with high accuracy. The correctness of this theory can no longer be called into question. Right after its discovery by Albert Einstein in 1905, special relativity was only gradually accepted because it made numerous predictions contradicting common sense, fervently castigated by Einstein, and also defied experiment for too long a time. It was only with the advent of particle or high energy physics that matter could be ac

  6. Obesity-related behaviors among poor adolescents and young adults: Is social position associated with risk behaviors?

    Directory of Open Access Journals (Sweden)

    Miranda Lucia Ritterman Weintraub

    2015-10-01

    Full Text Available This cross-sectional study examines multiple dimensions of social position in relation to obesity-related behaviors in an adolescent and young adult population. In addition to using conventional measures of social position, including parental education and household expenditures, we explore the usefulness of three youth-specific measures of social position—community and society subjective social status and school dropout status. Data is taken from a 2004 house-to-house survey of urban households within the bottom 20th percentile of income distribution within seven states in Mexico. A total of 5,321 Mexican adolescents, aged 12-22 years, provided information on obesity-related behaviors (e.g. diet, physical activity, sedentary behavior and indicators of subjective and objective social position. A parent in each household provided information on socioeconomic status of the parent and household. Ordinal logistic regressions are used to estimate the associations of parental, household and adolescent indicators of social position and obesity-related risk behaviors. Those adolescents with the highest odds of adopting obesity risk behaviors were the ones who perceived themselves as lower in social status in reference to their peer community and those who had dropped out of school. We found no significant associations between parental education or household expenditures and obesity-related risk behaviors. Immediate social factors in adolescents' lives may have a strong influence on their health-related behaviors. This study provides evidence for the usefulness of two particular measures, both of which are youth-specific. Adolescents and young adults who have dropped out of school and those with lower perceived relative social position within their community are more likely to be at-risk for obesity-related behaviors than those with higher relative social position. We conclude that youth-specific measures may be important in identifying the most at

  7. Does an association between student evaluations of related CDIO courses exist?

    DEFF Research Database (Denmark)

    Ersbøll, Bjarne Kjær; Sliusarenko, Tamara; Clemmensen, Line Katrine Harder

    2011-01-01

    This paper analyses routine course evaluation performed by students in the computer science related professional bachelor degree educations at DTU. Specifically, a set of two related courses are considered. The courses are: “Introductory Programming” and “Development Methods for IT-Systems”. Both...... courses include lectures and lab work. It is seen that both similarities and differences in the evaluations can be found. The similarities and differences can in part be used to assess if the CDIO concept has been implemented as it was intended and possible adjustments can be suggested....

  8. No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes.

    Science.gov (United States)

    Soerensen, Mette; Nygaard, Marianne; Debrabant, Birgit; Mengel-From, Jonas; Dato, Serena; Thinggaard, Mikael; Christensen, Kaare; Christiansen, Lene

    2016-06-01

    In this study we explored the association between aging-related phenotypes previously reported to predict survival in old age and variation in 77 genes from the DNA repair pathway, 32 genes from the growth hormone 1/ insulin-like growth factor 1/insulin (GH/IGF-1/INS) signalling pathway and 16 additional genes repeatedly considered as candidates for human longevity: APOE, APOA4, APOC3, ACE, CETP, HFE, IL6, IL6R, MTHFR, TGFB1, SIRTs 1, 3, 6; and HSPAs 1A, 1L, 14. Altogether, 1,049 single nucleotide polymorphisms (SNPs) were genotyped in 1,088 oldest-old (age 92-93 years) Danes and analysed with phenotype data on physical functioning (hand grip strength), cognitive functioning (mini mental state examination and a cognitive composite score), activity of daily living and self-rated health. Five SNPs showed association to one of the phenotypes; however, none of these SNPs were associated with a change in the relevant phenotype over time (7 years of follow-up) and none of the SNPs could be confirmed in a replication sample of 1,281 oldest-old Danes (age 94-100). Hence, our study does not support association between common variation in the investigated longevity candidate genes and aging-related phenotypes consistently shown to predict survival. It is possible that larger sample sizes are needed to robustly reveal associations with small effect sizes. PMID:26946122

  9. dbAARD & AGP: A computational pipeline for the prediction of genes associated with age related disorders.

    Science.gov (United States)

    Srivastava, Isha; Gahlot, Lokesh Kumar; Khurana, Pooja; Hasija, Yasha

    2016-04-01

    The atrocious behavioral and physiological shift with aging accelerate occurrence of deleterious disorders. Contemporary research is focused at uncovering the role of genetic associations in age-related disorders (ARDs). While the completion of the Human Genome Project and the HapMap project has generated huge amount of data on genetic variations; Genome-Wide Association Studies (GWAS) have identified genetic variations, essentially SNPs associated with several disorders including ARDs. However, a repository that houses all such ARD associations is lacking. The present work is aimed at filling this void. A database, dbAARD (database of Aging and Age Related Disorders) has been developed which hosts information on more than 3000 genetic variations significantly (p-value resources have been made available online at http://genomeinformatics.dce.edu/dbAARD/ and http://genomeinformatics.dce.edu/AGP/ respectively for easy retrieval and usage by the scientific community. We believe that this work may facilitate the analysis of plethora of variants associated with ARDs and provide cues for deciphering the biology of aging. PMID:26836976

  10. Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort.

    Directory of Open Access Journals (Sweden)

    Paul G Shiels

    Full Text Available BACKGROUND: It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study investigated the association of socio-economic and lifestyle factors, as well as traditional and novel risk factors, with biological-ageing, as measured by telomere length, in a Glasgow based cohort that included individuals with extreme socio-economic differences. METHODS: A total of 382 blood samples from the pSoBid study were available for telomere analysis. For each participant, data was available for socio-economic status factors, biochemical parameters and dietary intake. Statistical analyses were undertaken to investigate the association between telomere lengths and these aforementioned parameters. RESULTS: The rate of age-related telomere attrition was significantly associated with low relative income, housing tenure and poor diet. Notably, telomere length was positively associated with LDL and total cholesterol levels, but inversely correlated to circulating IL-6. CONCLUSIONS: These data suggest lower socio-economic status and poor diet are relevant to accelerated biological ageing. They also suggest potential associations between elevated circulating IL-6, a measure known to predict cardiovascular disease and diabetes with biological ageing. These observations require further study to tease out potential mechanistic links.

  11. Community Knowledge about Water: Who Has Better Knowledge and Is This Associated with Water-Related Behaviors and Support for Water-Related Policies?

    Directory of Open Access Journals (Sweden)

    Angela J Dean

    Full Text Available Sustainable approaches to water management require broad community acceptance of changes in policy, practice and technology, which in turn, requires an engaged community. A critical first step in building an engaged community is to identify community knowledge about water management, an issue rarely examined in research. To address this, we surveyed a representative sample of Australian adults (n = 5172. Knowledge was assessed using 15 questions about impact of household activities on waterways, the urban water cycle, and water management. This survey also examined demographics, psychosocial characteristics, exposure to water-related information, and water-related behaviors and policy support. Participants correctly answered a mean of 8.0 questions (Range 0-15. Most respondents knew that household actions can reduce water use and influence waterway health, whereas less than one third correctly identified that domestic wastewater is treated prior to entering waterways, urban stormwater is not treated, and that these are carried via different pipes. Higher water knowledge was associated with older age, higher education and living in non-urban areas. Poorer water knowledge was associated with speaking a language other than English in the home. Garden size, experience of water restrictions, satisfaction, waterway use for swimming, and certain information sources were also associated with knowledge. Greater water knowledge was associated with adoption of water-saving and pollution-reduction behaviors, and support for both alternative water sources and raingardens. These findings confirm the importance of community knowledge, and identify potential subgroups who may require additional targeting to build knowledge and support for water management initiatives.

  12. Community Knowledge about Water: Who Has Better Knowledge and Is This Associated with Water-Related Behaviors and Support for Water-Related Policies?

    Science.gov (United States)

    Fielding, Kelly S.; Newton, Fiona J.

    2016-01-01

    Sustainable approaches to water management require broad community acceptance of changes in policy, practice and technology, which in turn, requires an engaged community. A critical first step in building an engaged community is to identify community knowledge about water management, an issue rarely examined in research. To address this, we surveyed a representative sample of Australian adults (n = 5172). Knowledge was assessed using 15 questions about impact of household activities on waterways, the urban water cycle, and water management. This survey also examined demographics, psychosocial characteristics, exposure to water-related information, and water-related behaviors and policy support. Participants correctly answered a mean of 8.0 questions (Range 0–15). Most respondents knew that household actions can reduce water use and influence waterway health, whereas less than one third correctly identified that domestic wastewater is treated prior to entering waterways, urban stormwater is not treated, and that these are carried via different pipes. Higher water knowledge was associated with older age, higher education and living in non-urban areas. Poorer water knowledge was associated with speaking a language other than English in the home. Garden size, experience of water restrictions, satisfaction, waterway use for swimming, and certain information sources were also associated with knowledge. Greater water knowledge was associated with adoption of water-saving and pollution-reduction behaviors, and support for both alternative water sources and raingardens. These findings confirm the importance of community knowledge, and identify potential subgroups who may require additional targeting to build knowledge and support for water management initiatives. PMID:27428372

  13. Community Knowledge about Water: Who Has Better Knowledge and Is This Associated with Water-Related Behaviors and Support for Water-Related Policies?

    Science.gov (United States)

    Dean, Angela J; Fielding, Kelly S; Newton, Fiona J

    2016-01-01

    Sustainable approaches to water management require broad community acceptance of changes in policy, practice and technology, which in turn, requires an engaged community. A critical first step in building an engaged community is to identify community knowledge about water management, an issue rarely examined in research. To address this, we surveyed a representative sample of Australian adults (n = 5172). Knowledge was assessed using 15 questions about impact of household activities on waterways, the urban water cycle, and water management. This survey also examined demographics, psychosocial characteristics, exposure to water-related information, and water-related behaviors and policy support. Participants correctly answered a mean of 8.0 questions (Range 0-15). Most respondents knew that household actions can reduce water use and influence waterway health, whereas less than one third correctly identified that domestic wastewater is treated prior to entering waterways, urban stormwater is not treated, and that these are carried via different pipes. Higher water knowledge was associated with older age, higher education and living in non-urban areas. Poorer water knowledge was associated with speaking a language other than English in the home. Garden size, experience of water restrictions, satisfaction, waterway use for swimming, and certain information sources were also associated with knowledge. Greater water knowledge was associated with adoption of water-saving and pollution-reduction behaviors, and support for both alternative water sources and raingardens. These findings confirm the importance of community knowledge, and identify potential subgroups who may require additional targeting to build knowledge and support for water management initiatives. PMID:27428372

  14. Drug-Related Hospital Visits and Admissions Associated with Laboratory or Physiologic Abnormalities-A Systematic-Review.

    Directory of Open Access Journals (Sweden)

    Kerry Wilbur

    Full Text Available Countless studies have demonstrated that many emergency-room visits and hospital admissions are drug-related and that a significant proportion of these drug-related visits (DRVs are preventable. It has not been previously studied which DRVs could be prevented through enhanced monitoring of therapy. The objective of the study was to determine the incidence of DRVs attributed to laboratory or physiologic abnormalities. Three authors independently performed comprehensive searches in relevant health care databases using pre-determined search terms. Articles discussing DRV associated with poisoning, substance abuse, or studied among existing in-patient populations were excluded. Study country, year, sample, design, duration, DRV identification method, proportion of DRVs associated with laboratory or physiologic abnormalities and associated medications were extracted. The three authors independently assessed selected relevant articles according to the Strengthening the reporting of observational studies in epidemiology (STROBE as applicable according to the studies' methodology. The initial literature search yielded a total of 1,524 articles of which 30 articles meeting inclusion criteria and reporting sufficient laboratory or physiologic data were included in the overall analysis. Half employed prospective methodologies, which included both chart review and patient interview; however, the overwhelming majority of identified studies assessed only adverse drug reactions (ADRs as a drug-related cause for DRV. The mean (range prevalence of DRVs found in all studies was 15.4% (0.44%-66.7% of which an association with laboratory or physiologic abnormalities could be attributed to a mean (range of 29.4% (4.3%-78.1% of cases. Most laboratory-associated DRVs could be linked to immunosuppressant, antineoplastic, anticoagulant and diabetes therapy, while physiologic-associated DRVs were attributed to cardiovascular therapies and NSAIDs. Significant proportions

  15. Vision-Related Quality of Life in Patients with Inactive HLA-B27-Associated-Spectrum Anterior Uveitis.

    Science.gov (United States)

    Hoeksema, Lisette; Los, Leonoor I

    2016-01-01

    We investigated the vision-related quality of life (VR-QOL) in patients with HLA-B27 associated anterior uveitis (AU). The study was conducted in 2012 at the ophthalmology department of the University Medical Center of Groningen. We included AU patients who were HLA-B27 positive and/or were diagnosed by a rheumatologist with an HLA-B27 associated systemic disease. Sixty-one of 123 (50%) adult patients participated. All patients filled-out the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25), Beck Depression Inventory (BDI-II), social support lists and an additional questionnaire for gathering general information. Medical records were reviewed for clinical characteristics. Analyses were conducted on various patient and ocular characteristics. We compared our NEI VFQ-25 scores with those previously found in the literature. Our main outcome measures were VR-QOL scores and their associations with various general patient and ocular characteristics. We found that the NEI VFQ-25 mean overall composite score was 88.9±8.8, which is relatively high, but lower than that found in a normal working population. The mean general health score was 47.4±20.8, which is lower than in patients with other ocular diseases. Patients with a systemic disease scored significantly lower on general health and VR-QOL, compared to patients without a systemic disease. Patients with a depression (6/59 (10%)) frequently had ankylosing spondylitis (5/6 patients) and they scored significantly worse on VR-QOL. We concluded that patients with HLA-B27 associated AU have a relatively high VR-QOL. However, the presence of a systemic disease is associated with lower VR-QOL and general health scores. In addition, depression is associated with a lower VR-QOL. PMID:26808922

  16. Parents' Emotion Related Beliefs and Behaviors and Child Grade: Associations with Children's Perceptions of Peer Competence

    Science.gov (United States)

    Wong, Maria S.; Diener, Marissa L.; Isabella, Russell A.

    2008-01-01

    Mothers' and fathers' beliefs and reported behaviors regarding negative emotional expression and observed family negative emotion expressiveness were investigated as predictors of first-, third-, and fifth-grade children's self-reported peer competence. Parents' beliefs were related to their reported behaviors, and mothers accepted and encouraged…

  17. The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia

    DEFF Research Database (Denmark)

    Håvik, Bjarte; Le Hellard, Stephanie; Rietschel, Marcella;

    2011-01-01

    found across all three samples for eight common SNPs in the complement control-related gene CSMD2 (CUB and Sushi Multiple Domains 2) on chromosome 1p35.1-34.3, of which rs911213 reached a statistical significance comparable to that of a genome wide threshold (p value = 4.0 × 10(-8); odd ratio = .73, 95...

  18. Modulative effects of COMT haplotype on age-related associations with brain morphology.

    Science.gov (United States)

    Lee, Annie; Qiu, Anqi

    2016-06-01

    Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of individuals COMT SNPs (rs737865, val158met, rs165599) and its haplotypes in age-related brain morphology using an Asian sample with 174 adults aged from 21 to 80 years. We showed an age-related decline in cortical thickness of the dorsal visual pathway, including the left dorsolateral prefrontal cortex, bilateral angular gyrus, right superior frontal cortex, and age-related shape compression in the basal ganglia as a function of the genotypes of the individual COMT SNPs, especially COMT val158met. Using haplotype trend regression analysis, COMT haplotype probabilities were estimated and further revealed an age-related decline in cortical thickness in the default mode network (DMN), including the posterior cingulate, precuneus, supramarginal and paracentral cortex, and the ventral visual system, including the occipital cortex and left inferior temporal cortex, as a function of the COMT haplotype. Our results provided new evidence on an antagonistic pleiotropic effect in COMT, suggesting that genetically programmed neural benefits in early life may have a potential bearing towards neural susceptibility in later life. Hum Brain Mapp 37:2068-2082, 2016. © 2016 Wiley Periodicals, Inc. PMID:26920810

  19. Understanding Associations of Control Beliefs, Social Relations, and Well-Being in Older Adults with Osteoarthritis

    Science.gov (United States)

    Ferreira, Vanessa M.; Sherman, Aurora M.

    2006-01-01

    Control beliefs and social relationships have been individually assessed in relation to adaptation to chronic illness, although only rarely together. Further, some control scales show psychometric limitations in older adult samples. To address these concerns, a scale assessing external control was created by factor analyzing the items from…

  20. Aversive Parenting in China: Associations with Child Physical and Relational Aggression

    Science.gov (United States)

    Nelson, David A.; Hart, Craig H.; Yang, Chongming; Olsen, Joseph A.; Jin, Shenghua

    2006-01-01

    This study assessed the combined and differential contributions of Chinese mothers and fathers (in terms of spouse-reported physically coercive and psychologically controlling parenting) to the development of peer-reported physical and relational aggression in their preschool-age children (mean age of 5 years). Results of the two-group (boys and…

  1. Positive and Negative Alcohol-Related Consequences: Associations with Past Drinking

    Science.gov (United States)

    Lee, Christine M.; Maggs, Jennifer L.; Neighbors, Clayton; Patrick, Megan E.

    2011-01-01

    While recent attention suggests that positive and negative alcohol-related expectancies are important determinants of alcohol use, less is known about what types of consequences young people report actually experiencing when drinking alcohol. The present study (N = 742, 54% women) examined positive (Fun/Social, Relaxation/Coping, Positive Image)…

  2. Mentoring as It Relates to Persistence in Associate Degree Nursing Students

    Science.gov (United States)

    Peltz, Caroline M.

    2013-01-01

    Students who are preparing to become registered nurses are more likely to attend community colleges due to the unequal distribution of financial resources to educational systems that have evolved from the impact of globalization. The purpose of this descriptive cross-sectional study was to increase the understanding of mentoring as it relates to…

  3. Environmental Relative Moldiness Index and Associations with Home Characteristics and Infant Wheeze

    Science.gov (United States)

    Possible relationships between mold contamination, as described by the Environmental Relative Moldiness Index (ERMI), home characteristics, and the development of wheeze in the first year of life were evaluated among a cohort of urban infants (n = 103) in Syracuse, New York. Pre...

  4. Modeling Relations among Discrete Developmental Processes: A General Approach to Associative Latent Transition Analysis

    Science.gov (United States)

    Bray, Bethany C.; Lanza, Stephanie T.; Collins, Linda M.

    2010-01-01

    To understand one developmental process, it is often helpful to investigate its relations with other developmental processes. Statistical methods that model development in multiple processes simultaneously over time include latent growth curve models with time-varying covariates, multivariate latent growth curve models, and dual trajectory models.…

  5. Undecidability of Consequence Relation in Full Non-associative Lambek Calculus

    Czech Academy of Sciences Publication Activity Database

    Chvalovský, Karel

    2015-01-01

    Roč. 80, č. 2 (2015), s. 567-586. ISSN 0022-4812 R&D Projects: GA ČR GAP202/10/1826 Institutional support: RVO:67985807 Keywords : substructural logics * consequence relation * undecidability * tag systems * word problem * rewriting systems Subject RIV: BA - General Mathematics Impact factor: 0.541, year: 2014

  6. Building characteristics associated with moisture related problems in 8,918 Swedish dwellings

    DEFF Research Database (Denmark)

    Hagerhed-Engman, L.; Bornehag, Carl-Gustaf; Sundell, Jan

    2009-01-01

    Moisture problems in buildings have in a number of studies been shown to increase the risk for respiratory symptoms. The study Dampness in Buildings and Health (DBH) was initiated with the aim to identify health relevant exposures related to dampness in buildings. A questionnaire study about home...

  7. Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs.

    Directory of Open Access Journals (Sweden)

    Vipin Gupta

    Full Text Available Obesity is an established risk factor for type 2 diabetes (T2D and they are metabolically related through the mechanism of insulin resistance. In order to explore how common genetic variants associated with T2D correlate with body mass index (BMI, we examined the influence of 25 T2D associated loci on obesity risk. We used 5056 individuals (2528 sib-pairs recruited in Indian Migration Study and conducted within sib-pair analysis for six obesity phenotypes. We found associations of variants in CXCR4 (rs932206 and HHEX (rs5015480 with higher body mass index (BMI (β=0.13, p=0.001 and (β=0.09, p=0.002, respectively and weight (β=0.13, p=0.001 and (β=0.09, p=0.001, respectively. CXCR4 variant was also strongly associated with body fat (β=0.10, p=0.0004. In addition, we demonstrated associations of CXCR4 and HHEX with overweight/obesity (OR=1.6, p=0.003 and (OR=1.4, p=0.002, respectively, in 1333 sib-pairs (2666 individuals. We observed marginal evidence of associations between variants at six loci (TCF7L2, NGN3, FOXA2, LOC646279, FLJ39370 and THADA and waist hip ratio (WHR, BMI and/or overweight which needs to be validated in larger set of samples. All the above findings were independent of daily energy consumption and physical activity level. The risk score estimates based on eight significant loci (including nominal associations showed associations with WHR and body fat which were independent of BMI. In summary, we establish the role of T2D associated loci in influencing the measures of obesity in Indian population, suggesting common underlying pathophysiology across populations.

  8. Influence of Salt Intake on Association of Blood Uric Acid with Hypertension and Related Cardiovascular Risk.

    Directory of Open Access Journals (Sweden)

    Lei Hou

    Full Text Available A relationship of blood uric acid (UA with hypertension and cardiovascular risk is under debate thus salt intake is hypothesized to contribute to such associations.In this cross-sectional study, stratified cluster random sampling elicited a sample of 1805 Kazakhs with 92.4% compliance. Hypertension and moderate-or-high total cardiovascular risk (mTCR were defined according to guidelines. Sodium intake was assessed by urinary sodium excretion. Prevalence ratios (PRs were used to express associations of UA with hypertension and mTCR.In the highest tertile of sodium intake in women, the adjusted PRs (95% confidence intervals of low to high quartiles compared with the lowest quartile of UA, were 1.22(0.78-1.91, 1.18(0.75-1.85, and 1.65(1.09-2.51 for hypertension and 1.19(0.74-1.90, 1.39(0.91-2.11, and 1.65(1.10-2.47 for mTCR (P for trend <0.05. However, these findings were not shown for other sodium intake levels. There were similar results in men. PRs markedly increased with a concomitant increase in UA and sodium intake and there was a significant interaction (P = 0.010 for mTCR with PRs of 1.69(1.10-2.60 for men and 3.70(2.09-6.52 for women in those with the highest compared with the lowest quartile of UA and tertile of sodium intake. Similar findings were shown for hypertension.This study implied that a high salt intake may enhance the associations of UA with hypertension and cardiovascular risk.

  9. Associations between pedagogues attitudes, praxis and policy in relation to physical activity of children in kindergarten

    DEFF Research Database (Denmark)

    Mikkelsen, Bent Egberg

    2011-01-01

    This paper reports on associations between physical activity, pedagogue ’ s attitudes towards promoting physical activity and the physical activity policies (PAP) in kindergarten. The paper deals with data on physical activity of 3 – 6 year olds in kindergarten which originates from a cross-secti...... should play an active role in the promotion of healthy lifestyle among kindergarten aged children. Strong municipal and institutional leadership as well as educational interventions in the curricula of pedagogues could be important ways to bring about such change....

  10. Association between SNPs within candidate genes and compounds related to boar taint and reproduction

    DEFF Research Database (Denmark)

    Moe, Maren; Lien, Sigbjørn; Aasmundstad, Torunn;

    2009-01-01

    were genotyped in more than 2800 individuals and several SNPs were found to be significantly (LRT > 5.4) associated with the different phenotypes. Genes with significant SNPs in either of the traits investigated include cytochrome P450 members CYP2E1, CYP21, CYP2D6 and CYP2C49, steroid 5alpha...... in this study indicate that polymorphisms in CYP2E1, CYP21, CYP2D6, CYP2C49, NGFIB and CTNND1 might be used to reduce levels of boar taint without affecting levels of testosterone, estrone sulphate, 17beta-estradiol or length of bulbo urethralis gland. Udgivelsesdato: July...

  11. Association between the related characters of hemispatial neglect and prognosis in stroke patients

    Institute of Scientific and Technical Information of China (English)

    Yongcai Wang; Lianzhong Wang; Shiwen Liu

    2006-01-01

    OBJECTIVE: To recognize the significances of the classification, evaluation, treatment, pathogenesis, etiological factors and related foci of hemispatial neglect (HSN) in the treatment and prognosis of stroke patients.DATA SOURCES: Articles related to HSN in stroke published in English from January 1985 to December 2002 were searched in Medline database by using the keywords of "stroke, hemispatial neglect (HSN), rehabilitation". Chinese relevant professional works and articles were also referred to.STUDY SELECTION: The data were primarily checked. Inclusive criteria: ① articles about the HSN symptoms in stroke; ② articles about the classification, evaluation, treatment, pathogenesis, etiological factors and related foci of HSN, as well as the treatment and prognosis of stroke. The repetitive studies or reviews were excluded.DATA EXTRACTION: Totally 474 articles related to HSN in stroke were collected, 43 of them were involved,and 431 repetitive studies or reviews were excluded.DATA SYNTHESIS: HSN can be classified as sensory neglect and motor neglect. Because HSN is caused by the injury of network structure which mediated directed attention, it is generally believed that the inferior parietal Iobule of dominant hemisphere is the most closely correlated with neglect. The main theories related to the pathogenesis of HSN at present include "internal instruction", "directed bradykinesia", "sensory attention", etc. The main clinical manifestations are setover in drawing lines, picture drawing towards one side, imitation towards one side, picture description towards one side, etc., which can be evaluated by the line bisection test, target cancellation test, picture drawing test and pegboard test. The most important thing for the treatment is to make the patients continuously concentrate on the neglected side.CONCLUSION: HSN is an indicator for the bad outcome of cerebrovascular disease, the symptoms take longer time to rehabilitate with slow recovery, but quite a

  12. Self-compassion as a moderator of thinness-related pressures' associations with thin-ideal internalization and disordered eating.

    Science.gov (United States)

    Tylka, Tracy L; Russell, Hannah L; Neal, Ashley A

    2015-04-01

    During situations that threaten personal adequacy, people high in self-compassion are kind and caring toward themselves, mindful of their distress, and recognize that being imperfect is part of the human experience. Therefore, self-compassion may offset certain disorders (e.g., eating disorders) associated with environmental threats (e.g., thinness-related pressures). In this cross-sectional study, we explored self-compassion's associations with threats involving thinness-related pressures (from friends, family, partners, and media), thin-ideal internalization, and disordered eating among an online sample of 435 U.S. community women. Findings indicated that self-compassion buffered the links from media thinness-related pressure to disordered eating and thin-ideal internalization. Furthermore, higher self-compassion was directly associated with fewer perceived thinness-related pressures, lower thin-ideal internalization, and lower disordered eating. Collectively, these findings add to the growing conceptualization of self-compassion as beneficial to eating behavior and help justify pursuing rigorous longitudinal and clinical examinations of self-compassion as a protective factor of disordered eating. PMID:25536526

  13. Case 229: Burn-related Global Ankylosis of Interphalangeal Joints with Associated Acroosteolysis.

    Science.gov (United States)

    Davis, Derik L; Resnik, Charles S

    2016-05-01

    History A 50-year-old woman presented with a 6-month history of polyarthralgia involving the left and right hands, wrists, elbows, ankles, and knees. Her pain was not associated with morning stiffness but did worsen over the course of the day. She denied experiencing fevers, chills, or mouth ulcers. She did not report paresthesias or blue discoloration of her fingers when they were exposed to cold. Her family history was remarkable for an aunt who died of systemic lupus erythematosus and for a brother with arthritis. Her medical history was remarkable for vitamin D deficiency, hypertension, and rehabilitation for burns. At clinical examination, she had mild tenderness to palpation of her joints, without associated erythema, swelling, or crepitus. Healed skin grafts were also noted. Blood chemistry tests revealed a rheumatoid factor of 8.5 IU/mL (normal range, 0-13.9 IU/mL), an erythrocyte sedimentation rate of 2 mm/hr (normal range, 0-40 mm/hr), and a C-reactive protein value of 0.4 mg/L (3.8 nmol/L) (normal range, 0-4.9 mg/L [0-46.7 nmol/L]). Antinuclear antibodies test results were negative. Radiography of the right and left hands was performed. PMID:27089192

  14. Association of Health-related Quality of Life with Health Examination and Lifestyles of Government Managers in China

    Institute of Scientific and Technical Information of China (English)

    HOU Changrong; L(U) Bin; LU Zuxun; QIN Shilong

    2007-01-01

    In order to study the association of each item of a health examination and lifestyles with health-related quality of life (HRQoL), a cross-sectional survey by a self-administered questionnaire using the 12-Item Short Form Health Survey (SF-12, version 1) was conducted on 145 government managers that took health examinations in Tongji Hospital, Wuhan, China during 2005. The results showed that the determinations of organic functions including BMI, hemoglobin, blood platelet count,urine protein, urine WBC and lipid metabolism (LDL) were associated with HRQoL. The lifestyle items including age, sex, life satisfaction, drinking alcohol and kind of alcohol drunk, drinking tea,sleep quality and adhering to bedtime, working overtime, work stress were associated with HRQoL in the multiple regression models. Sex, age and life satisfaction were the lifestyle items most closely associated with HRQoL, while LDL, hemoglobin and urine protein were the health examination items most closely associated HRQoL. This study revealed that both lifestyle and health examination items were associated with HRQoL.

  15. Role of microRNA 21 in diabetes and associated/related diseases.

    Science.gov (United States)

    Sekar, Durairaj; Venugopal, Basam; Sekar, Punitha; Ramalingam, Krishnan

    2016-05-10

    Diabetes mellitus (DM) is a disease related to metabolic disorder and becoming an epidemic in developing countries. Current treatments for DM include modified lifestyle practice, obesity treatment, oral hypoglycemic agents, and insulin sensitizers, yet no cure is available in sight for the disease, despite it requires new insight into the molecular and pathophysiology. MicroRNAs (miRNAs) are small noncoding RNAs considered as of greater biological importance and controls molecular signaling pathways in diabetic pathogenesis. The microRNA 21 is an important microRNA frequently upregulated in all types of diseases suggesting that it plays an important role in cell proliferation, and apoptosis. The present mini review highlights the recent investigations related to the importance of miR-21 in different types of DM based on the up-to-date reports. PMID:26826461

  16. Prevalence of Dental Caries among the Population of Gwalior (India) in Relation of Different Associated Factors

    OpenAIRE

    Khan, Abdul Arif; Jain, Sudhir K.; Shrivastav, Archana

    2008-01-01

    Objectives India is unique in entire world due to variety of dietary habits in population. Many people of India follow totally vegetarian life style through their entire life time due to some religious and cultural reasons. Present study tried to analyze the role of different factors in the occurrence of dental caries including dietary habit. Methods Persons suffering with dental caries were examined for the type of dental caries in relation to different factors. Dental examination was perfor...

  17. An Unusual Association: Iliopsoas Bursitis Related to Calcium Pyrophosphate Crystal Arthritis

    OpenAIRE

    Marco Di Carlo; Antonella Draghessi; Marina Carotti; Fausto Salaffi

    2015-01-01

    A 71-year-old man with osteoarthritis and chondrocalcinosis came to our observation developing a swelling in the groin region after a recent left colectomy for adenocarcinoma. The imaging techniques revealed the presence of an iliopsoas bursitis in connection with the hip. The synovial fluid analysis detected the presence of calcium pyrophosphate (CPP) crystals and allowed the final and unusual diagnosis of iliopsoas bursitis related to acute CPP crystal hip arthritis.

  18. Association of Traffic-Related Air Pollution with Children’s Neurobehavioral Functions in Quanzhou, China

    OpenAIRE

    Wang, Shunqin; Zhang, Jinliang; Zeng, Xiaodong; Zeng, Yimin; Wang, Shengchun; Chen, Shuyun

    2009-01-01

    Background With the increase of motor vehicles, ambient air pollution related to traffic exhaust has become an important environmental issue in China. Because of their fast growth and development, children are more susceptible to ambient air pollution exposure. Many chemicals from traffic exhaust, such as carbon monoxide, nitrogen dioxide, and lead, have been reported to show adverse effects on neurobehavioral functions. Several studies in China have suggested that traffic exhaust might affec...

  19. Long-term Disability Associated With War-related Experience Among Vietnam Veterans

    OpenAIRE

    Clarke, Philip M.; Gregory, Robert; Salomon, Joshua A.

    2015-01-01

    Background: Recent combat operations have involved large numbers of personnel. Long-term health effects of military deployment remain largely unknown. Objectives: To examine patterns and trends in long-term disability among combat veterans and to relate disability to aspects of wartime experience. Participants: A total of 60,228 Australian military personnel deployed between 1962 and 1975 during the Vietnam War, and 82,877 military personnel who were not deployed overseas. Outcome Measures: A...

  20. Long-term Disability Associated With War-related Experience Among Vietnam Veterans: Retrospective Cohort Study

    OpenAIRE

    Clarke, Philip M.; Gregory, Robert; Salomon, Joshua A.

    2015-01-01

    Background: Recent combat operations have involved large numbers of personnel. Long-term health effects of military deployment remain largely unknown. Objectives: To examine patterns and trends in long-term disability among combat veterans and to relate disability to aspects of wartime experience. Participants: A total of 60,228 Australian military personnel deployed between 1962 and 1975 during the Vietnam War, and 82,877 military personnel who were not deployed overseas. Outcome Measures: A...

  1. Undecidability of consequence relation in Full Non-associative Lambek Calculus

    Czech Academy of Sciences Publication Activity Database

    Chvalovský, Karel

    Vienna : Vienna University of Technology, 2014 - (Baaz, M.; Ciabattoni, A.; Hetzl, S.). s. 153-154 [LATD 2014. Logic, Algebra and Truth Degrees. 16.07.2014-19.07.2014, Vienna] R&D Projects: GA ČR GAP202/10/1826 Institutional support: RVO:67985807 Keywords : substructural logics * consequence relation * undecidability * tag systems * word problem * rewriting systems Subject RIV: BA - General Mathematics

  2. Safety-related issues associated with implementing wireless systems in nuclear facilities

    International Nuclear Information System (INIS)

    Currently, wireless technology is not used as an integral element of safety-related systems in nuclear facilities. The most prevalent introductory uses of wireless technology are for in-facility communications among personnel and for supplemental information transmission. However, further system upgrades and implementations at new facilities might introduce wireless communications into safety-significant applications. This paper documents the deployment issues and implementation considerations that can contribute to the technical basis for guidance on wireless systems. (authors)

  3. Prevalence and risk factors associated with nutrition-related noncommunicable diseases in the Eastern Mediterranean region

    OpenAIRE

    Musaiger AO; Al-Hazzaa HM

    2012-01-01

    Abdulrahman O Musaiger1, Hazzaa M Al-Hazzaa21Nutrition and Health Studies Unit, Deanship of Scientific Research, University of Bahrain, Bahrain, and Arab Center for Nutrition, Bahrain; 2Exercise Physiology Laboratory, Department of Physical Education and Movement Science, College of Education, and Scientific Board, Obesity Research Chair, King Saud University, Riyadh, Saudi ArabiaAbstract: This paper reviews the current situation concerning nutrition-related noncommunicable diseases (N-NCDs) ...

  4. Alcohol and relatively pure cannabis use, but not schizotypy, are associated with cognitive attenuations

    OpenAIRE

    Herzig, Daniela A.; David eNutt; Christine eMohr

    2014-01-01

    Elevated schizotypy relates to similar cognitive attenuations as seen in psychosis and cannabis/polydrug use. Also, in schizotypal populations cannabis and polydrug (including licit drug) use are enhanced. These cognitive attenuations may therefore either be a behavioural marker of psychotic (-like) symptoms or the consequence of an enhanced drug use in schizotypal populations. To elucidate this, we investigated the link between cognitive attenuation and cannabis use in largely pure cannabis ...

  5. Alcohol and Relatively Pure Cannabis Use, but Not Schizotypy, are Associated with Cognitive Attenuations

    OpenAIRE

    Herzig, Daniela A.; David J. Nutt; Mohr, Christine

    2014-01-01

    Elevated schizotypy relates to similar cognitive attenuations as seen in psychosis and cannabis/polydrug use. Also, in schizotypal populations cannabis and polydrug (including licit drug) use are enhanced. These cognitive attenuations may therefore either be a behavioral marker of psychotic (-like) symptoms or the consequence of enhanced drug use in schizotypal populations. To elucidate this, we investigated the link between cognitive attenuation and cannabis use in largely pure cannabis user...

  6. BDNF is Associated With Age-Related Decline in Hippocampal Volume

    OpenAIRE

    Erickson, Kirk I.; Prakash, Ruchika Shaurya; Michelle W Voss; Chaddock, Laura; Heo, Susie; McLaren, Molly; Pence, Brandt D.; Martin, Stephen A.; Vieira, Victoria J.; Jeffrey A. Woods; Kramer, Arthur F.

    2010-01-01

    Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger hippocampal decay in aging humans remains a matter of speculation. In rodents, brain derived neurotrophic factor (BDNF) promotes the growth and proliferation of cells in the hippocampus and is important in long-term potentiation and memory formation. In humans, circulating levels of BDNF decline with advancing age and a genetic polymorphism for BDNF has been related to gray matter volume loss in old age....

  7. Drug Related Problems and their Association with Hospital Length of Stay of Pneumonia Patients

    OpenAIRE

    Nasution, Azizah; Hidayah N; Rinza D; Rosidah; Harahap U

    2016-01-01

    BACKGROUND: Pneumonia remains a serious worldwide problem and can altach people at a wide range of age at all seasons causing high consumption of drugs, drug-related problems (DRPs), negative outcomes, increase of hospital length of stay (LOS), and even high mortality rate (Jeremy, 2007) OBJECTIVES: This study aimed to analyse incidence of DRPs and their impact on Hospital LOS of patients with pneumonia. METHODS: This retrospective cohort study ws undertaken on 70 patiens based on insu...

  8. High Cognitive Reserve is associated with a reduced age-related deficit in spatial conflict resolution.

    Directory of Open Access Journals (Sweden)

    Olga Puccioni

    2012-12-01

    Full Text Available Several studies support the existence of a specific age-related difficulty in suppressing potentially distracting information. The aim of the present study is to investigate whether spatial conflict resolution is selectively affected by aging. The way aging affects individuals could be modulated by many factors determined by the socieconomic status: we investigated whether factors such as cognitive reserve (CR and years of education may play a compensatory role against age-related deficits in the spatial domain. A spatial Stroop task with no feature repetitions was administered to a sample of 17 non-demented older adults (69-79 years old and 18 younger controls (18-34 years old matched for gender and years of education. The two age groups were also administered with measures of intelligence and CR. The overall spatial Stroop effect did not differ according to age, neither for speed nor for accuracy. The two age groups equally showed sequential effects for congruent trials: reduced response times (RTs if another congruent trial preceded them, and accuracy at ceiling. For incongruent trials, older adults, but not younger controls, were influenced by congruency of trialn-1, since RTs increased with preceding congruent trials. Interestingly, such an age-related modulation negatively correlated with CR. These findings suggest that spatial conflict resolution in aging is predominantly affected by general slowing, rather than by a more specific deficit. However, a high level of CR seems to play a compensatory role for both factors.

  9. Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice

    DEFF Research Database (Denmark)

    Alkaissi, Hammoudi; Ekstrand, Jimmy; Jawad, Aksa;

    2016-01-01

    BACKGROUND: Following human mercury (Hg) exposure, the metal accumulates with considerable concentrations in kidney, liver, and brain. Although the toxicokinetics of Hg has been studied extensively, factors responsible for inter-individual variation in humans are largely unknown. Differences in...... accumulation of renal Hg between inbred mouse strains suggest a genetic inter-strain variation regulating retention or/and excretion of Hg. A.SW, DBA/2 and BALB/C mouse strains accumulate higher amounts of Hg than B10.S. OBJECTIVES: To find candidate genes associated with regulation of renal Hg concentrations....... METHODS: A.SW, B10.S and their F1 and F2 offspring were exposed for 6 weeks to 2.0 mg Hg/L drinking water. Genotyping with Microsatellites were conducted on 84 F2 mice for Genome-Wide Scan by using Ion Pair Reverse Phase High Performance Liquid Chromatography (IP RP HPLC). Quantitative trait loci (QTL...

  10. Morb-related dolerites associated with the Etendeka volcanics, northwestern Namibia

    International Nuclear Information System (INIS)

    The volcanic rocks of the Etendeka Formation are spatially associated with, and intruded by, three suites of dolerites. One suite of dolerite dykes are equivalent in composition to the Tafelberg- and Albin-type low-Ti basalts. The second suite of Etendeka dolerites, termed the Horingbaai dolerites, form thin dykes and sills which intrude Damaran granites and the base of the Etendeka lava succession near the coast of Namibia. The Sr- and Nd- isotope data for these samples is shown, together with Sr-isotope data for an additional five Horingbaai samples. The third suite of Etendeka dolerites, termed the Huab dolerites, form a complex of large sills intruding Damaran schists and Karoo sediments in the Huab River valley.It is concluded that the Huab dolerites and the Etendeka basalts are most likely to be immediately post-volcanic in age. 4 figs., 6 refs

  11. Music Retrieval Based on the Relation between Color Association and Lyrics

    Science.gov (United States)

    Nakamur, Tetsuaki; Utsumi, Akira; Sakamoto, Maki

    Various methods for music retrieval have been proposed. Recently, many researchers are tackling developing methods based on the relationship between music and feelings. In our previous psychological study, we found that there was a significant correlation between colors evoked from songs and colors evoked only from lyrics, and showed that the music retrieval system using lyrics could be developed. In this paper, we focus on the relationship among music, lyrics and colors, and propose a music retrieval method using colors as queries and analyzing lyrics. This method estimates colors evoked from songs by analyzing lyrics of the songs. On the first step of our method, words associated with colors are extracted from lyrics. We assumed two types of methods to extract words associated with colors. In the one of two methods, the words are extracted based on the result of a psychological experiment. In the other method, in addition to the words extracted based on the result of the psychological experiment, the words from corpora for the Latent Semantic Analysis are extracted. On the second step, colors evoked from the extracted words are compounded, and the compounded colors are regarded as those evoked from the song. On the last step, colors as queries are compared with colors estimated from lyrics, and the list of songs is presented based on similarities. We evaluated the two methods described above and found that the method based on the psychological experiment and corpora performed better than the method only based on the psychological experiment. As a result, we showed that the method using colors as queries and analyzing lyrics is effective for music retrieval.

  12. Expression of Msx-1 is suppressed in bisphosphonate associated osteonecrosis related jaw tissue-etiopathology considerations respecting jaw developmental biology-related unique features

    Directory of Open Access Journals (Sweden)

    Schlegel Karl A

    2010-10-01

    Full Text Available Abstract Background Bone-destructive disease treatments include bisphosphonates and antibodies against the osteoclast differentiator, RANKL (aRANKL; however, osteonecrosis of the jaw (ONJ is a frequent side-effect. Current models fail to explain the restriction of bisphosphonate (BP-related and denosumab (anti-RANKL antibody-related ONJ to jaws. Msx-1 is exclusively expressed in craniofacial structures and pivotal to cranial neural crest (CNC-derived periodontal tissue remodeling. We hypothesised that Msx-1 expression might be impaired in bisphosphonate-related ONJ. The study aim was to elucidate Msx-1 and RANKL-associated signal transduction (BMP-2/4, RANKL in ONJ-altered and healthy periodontal tissue. Methods Twenty ONJ and twenty non-BP exposed periodontal samples were processed for RT-PCR and immunohistochemistry. An automated staining-based alkaline phosphatase-anti-alkaline phosphatase method was used to measure the stained cells:total cell-number ratio (labelling index, Bonferroni adjustment. Real-time RT-PCR was performed on ONJ-affected and healthy jaw periodontal samples (n = 20 each to quantitatively compare Msx-1, BMP-2, RANKL, and GAPDH mRNA levels. Results Semi-quantitative assessment of the ratio of stained cells showed decreased Msx-1 and RANKL and increased BMP-2/4 (all p Conclusions These results explain the sclerotic and osteopetrotic changes of periodontal tissue following BP application and substantiate clinical findings of BP-related impaired remodeling specific to periodontal tissue. RANKL suppression substantiated the clinical finding of impaired bone remodelling in BP- and aRANKL-induced ONJ-affected bone structures. Msx-1 suppression in ONJ-adjacent periodontal tissue suggested a bisphosphonate-related impairment in cellular differentiation that occurred exclusively jaw remodelling. Further research on developmental biology-related unique features of jaw bone structures will help to elucidate pathologies restricted to

  13. Health and health-related quality of life in pig farmers carrying livestock-associated methicillin-resistant Staphylococcus aureus.

    Science.gov (United States)

    VAN Cleef, B A G L; VAN Benthem, B H B; Verkade, E J M; VAN Rijen, M M L; Kluytmans-VAN DEN Bergh, M F Q; Graveland, H; Bosch, T; Verstappen, K M H W; Wagenaar, J A; Heederik, D; Kluytmans, J A J W

    2016-06-01

    There is limited knowledge about the effect of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) carriage on health-related quality of life (QoL). With this study, we explored whether LA-MRSA causes infections or affects health-related QoL in pig farmers. This prospective cohort study surveyed persons working on 49 farrowing pig farms in The Netherlands for 1 year (2010-2011). On six sampling moments, nasal swabs, environmental samples and questionnaires on activities and infections were collected. At the end of the study year, persons were asked about their QoL using the validated SF-36 and EQ-5D questionnaires. Of 120 persons, 44 (37%) were persistent MRSA carriers. MRSA carriage was not associated with infections, use of antimicrobials, healthcare contact and health-related QoL items in univariate or multivariate analysis, most likely due to the 'healthy worker effect'. Despite high carriage rates, the impact of LA-MRSA carriage in this population of relatively healthy pig farmers on health and health-related QoL appears limited; more research is needed for confirmation. PMID:26733049

  14. The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy?

    DEFF Research Database (Denmark)

    Husemoen, LL; Toft, U.; Fenger, Mogens;

    2006-01-01

    aimed at examining the association between atopy and markers of impaired folate metabolism, i.e. MTHFR(C677T) genotype, plasma total homocysteine, and dietary intakes of methionine, folates, and vitamins B12, B6, and B2. METHODS: Cross-sectional population-based study of 1,671 male and female residents...... homocysteine was measured by fluorescent polarization immunoassay. Dietary vitamin intakes were estimated from a semi-quantitative food frequency questionnaire. RESULTS: The prevalence of atopy was associated with MTHFR(C677T) genotype. TT individuals had a significantly higher risk of atopy compared with CC....../CT individuals [odds ratio 1.76, 95% confidence interval (95% CI) 1.19-2.60]. Additionally, gene-diet interaction effects were identified. Dietary markers were negatively associated with risk of atopy in persons with the TT genotype. Total homocysteine was not related to atopy (odds ratio per 5 mumol/l = 1...

  15. [Health-related quality of life and factors associated with overweight and obesity in the pediatric population of Catalonia, Spain].

    Science.gov (United States)

    Rajmil, Luis; López-Aguilá, Sílvia; Mompart-Penina, Anna

    2011-12-01

    The aim of this work is to describe the health-related quality of life (HRQOL), and to analyze the associated factors to overweight/obesity in a representative sample of the Catalan population 0-14 years old. Proxyrespondents answered the child's questionnaire of the Encuesta de Salud de Cataluna (ESCA) 2006 (n = 2.200). Variables analyzed were weight and height, the KIDSCREEN-10 HRQOL questionnaire, and also scales on risky behaviors, physical activity, frequency of fast food consumption, and number of hours of television viewing. Logistic regression models were adjusted. In 31% of children HRQOL was excellent/very good. Risky behaviors and restriction of activity were the associated factors to the best and the worst HRQOL. Maternal level of education and some habits and behaviors were associated to overweight/obesity. The ESCA contributes with useful information to monitor and to assess interventions addressed to the children population. PMID:22310362

  16. Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

    DEFF Research Database (Denmark)

    Bown, Matthew J; Jones, Gregory T; Harrison, Seamus C;

    2011-01-01

    additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p <1 × 10(-5)). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low......-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined...

  17. Associations between the settings of exercise habits and health-related outcomes in community-dwelling older adults

    OpenAIRE

    Makino, Keitaro; Ihira, Hikaru; Mizumoto, Atsushi; Shimizu, Kotaro; Ishida, Toyoaki; Furuna, Taketo

    2015-01-01

    [Purpose] The purpose of this study was to examine the associations between the settings of exercise habits and health-related outcomes in community-dwelling older adults. [Subjects] A total of 304 Japanese community-dwelling older adults (70.3 ± 4.1 years; 113 males and 191 females) participated in this study. [Methods] Demographic characteristics, medical conditions, exercise habits, and health-related outcomes were assessed by face-to-face interviews and self-reported questionnaires. Older...

  18. Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood

    DEFF Research Database (Denmark)

    Faber, Carsten; Singh, Amardeep; Krüger Falk, Mads; Juel, Helene Bæk; Sørensen, Torben Lykke; Nissen, Mogens Holst

    2013-01-01

    PURPOSE: To examine the association between age-related changes in the T-cell compartment and prevalence of age-related macular degeneration (AMD). DESIGN: Case-control study. PARTICIPANTS: A total of 117 AMD cases and 106 controls were included prospectively. METHODS: Fresh-drawn peripheral blood...... levels of circulating aged CD56(+) CD28(-) T cells in patients with AMD. Although this supports the notion of AMD as a systemic disease, it also suggests that the adaptive immune system is implicated in its pathogenesis....

  19. Factors Associated with Pregnant Women’s Anticipations and Experiences of HIV-related Stigma in Rural Kenya

    OpenAIRE

    Cuca, Yvette P.; Onono, Maricianah; Bukusi, Elizabeth; Turan, Janet M.

    2012-01-01

    Pregnant women who fear or experience HIV-related stigma may not get care for their own health or medications to reduce perinatal transmission of HIV. This study examined factors associated with anticipating and experiencing HIV-related stigma among 1,777 pregnant women attending antenatal care clinics in rural Kenya. Women were interviewed at baseline, offered HIV testing and care, and a sub-set was re-interviewed at 4–8 weeks postpartum. Women who were older, had less education, whose husba...

  20. Independent risk of mechanical ventilation for AIDS-related Pneumocystis carinii pneumonia associated with bronchoalveolar lavage neutrophilia

    DEFF Research Database (Denmark)

    Bang, D.; Emborg, J.; Elkjaer, J.;

    2001-01-01

    failure requiring MV amongst patients with PCP treated in the era of adjunctive corticosteroid therapy. Furthermore, we studied factors associated with survival in relation to MV. Of 170 consecutive patients with AIDS-related PCP, 18 (11%) required MV. Thirteen of 18 ventilated patients died (72%). In a...... logistic regression analysis, higher age, increased bronchoalveolar lavage (BAL) neutrophilia and a positive BAL cytomegalovirus CMV culture were associated with the need of MV. In multivariate analyses, only BAL neutrophilia remained independently predictive of mechanical ventilation. In conclusion, short......-term mortality remained high after the introduction of adjunctive corticosteroid therapy. BAL neutrophilia may be a useful prognostic marker to identify patients at high risk of requiring mechanical ventilation Udgivelsesdato: 2001/8...

  1. Factors associated with the perception of side-effects relating to the use of contraceptive methods

    Directory of Open Access Journals (Sweden)

    Gerda Erasmus

    1985-09-01

    Full Text Available Limited research has been done in South Africa regarding the incidence of side-effects and perceptions of these among users of contraceptives. Numerous knowledge, attitude and practice (KAP surveys have been conducted by the Human Sciences Research Council (Erasmus 1981a; Erasmus 1981b; Erasmus 1982 ; Groenewald 1978 ; Lótter, Van Tonder 1976; Mostert, Malherbe 1974; Mostert 1974; Strydom 1981; Van der Merwe 1982 and in some of these studies questions concerning side-effects were included to determine reasons for discontinuation of specific contraceptive methods. The literature concerning research on side-effects related to contraceptive use usually pertains either to clinical studies

  2. First reported case of Staphylococcus condimenti infection associated with catheter-related bacteraemia

    Directory of Open Access Journals (Sweden)

    Y. Misawa

    2015-01-01

    Full Text Available We report a case of a patient who experienced a catheter-related bloodstream infection caused by Staphylococcus condimenti, which was first isolated from soy sauce mash. This is the first reported case of human infection. Although blood culture isolates and the catheter tip tube did not reveal coagulase or clumping factor, false-positive results were obtained from latex agglutination tests for clumping factor and protein A due to self-agglutination. Care is needed when performing only latex agglutination test without a coagulase test. Further studies are needed to determine the pathogenic potential of S. condimenti based on appropriate identification.

  3. Relation between adverse events associated with allopurinol and renal function in patients with gout

    OpenAIRE

    Vazquez-Mellado, J; E. Morales; Pacheco-Tena, C; Burgos-Vargas, R

    2001-01-01

    BACKGROUND—Because serious adverse reactions to allopurinol have been related to a reduce creatinine clearance rate and prolonged half life of oxypurinol, it has been recommended that the dose should be adjusted according to the rate of creatinine clearance. However, in some patients with gout the dose is not sufficient to reduce serum levels of uric acid (⩽390 µmol/l) and to halt disease progression.
OBJECTIVE—To determine the prevalence of adverse reactions attributable to allopurinol in pa...

  4. Earthquakes and associated topics in relation to nuclear power plant siting

    International Nuclear Information System (INIS)

    This Safety Guide was prepared as part of the Agency's programme for establishing Codes and Safety Guides relating to nuclear power plants. The main purpose of the text is to provide guidance on the determination of the design basis ground motions for a nuclear power plant at a chosen site and on the determination of the potential for surface faulting at that site. Additionally, the Guide discusses other permanent displacement phenomena (liquefaction, slope instability, subsidence and collapse) and introduces the topic of seismically induced flooding. Volcanic activity is not dealt with except in connection with tsunamis. 55 refs

  5. Dietary pattern and its association with the prevalence of obesity and related cardiometabolic risk factors among Chinese children.

    Directory of Open Access Journals (Sweden)

    Xianwen Shang

    Full Text Available BACKGROUND: The association of dietary pattern with chronic diseases has been investigated widely in western countries. However, information is quite limited among children in China. Our study is aimed to identify the dietary patterns of Chinese children and examine their association with obesity and related cardiometabolic risk factors. METHODS: A total of 5267 children were selected using multistage random sampling from 30 primary schools of 5 provincial capital cities in China. Dietary intake was derived from 24 hour dietary recall for three consecutive days. Anthropometric measurements, glucose and lipid profiles were obtained. Factor analysis combined with cluster analysis was used for identifying major dietary patterns. The associations of dietary patterns with obesity and related cardiometabolic risk factors were examined by logistic regression analysis. RESULTS: Three mutually exclusive dietary patterns were identified, which were labeled as the healthy dietary pattern, the transitive dietary pattern, and the Western dietary pattern. Compared with children of the healthy dietary pattern, the multiple-adjusted odds ratios (95% confidence interval (CI of obesity were 1.11 (0.89-1.38 for children with the transitive dietary pattern and 1.80 (1.15-2.81 for children with the Western dietary pattern, which was 1.31 (95%CI 1.09-1.56 and 1.71 (95%CI: 1.13-2.56, respectively, for abdominal obesity. The Western dietary pattern was associated with significantly higher concentrations of low-density lipoprotein cholesterol (P<.001, triglycerides (P<.001, systolic blood pressure (P = 0.0435 and fasting glucose (P = 0.0082 and a lower concentration of high-density lipoprotein cholesterol (P = 0.0023, as compared with the healthy dietary pattern. CONCLUSIONS: The Western dietary pattern characterized by red meat, eggs, refined grain and products, was positively associated with odds of obesity, the levels of plasma glucose, low-density lipoprotein

  6. The Moderating Role of Gender in the Prospective Associations Between Expectancies and Alcohol–Related Negative Consequences Among College Students

    OpenAIRE

    Thompson, Martie P.; Spitler, Hugh; McCoy, Thomas P.; Marra, Laura; Sutfin, Erin L.; Rhodes, Scott D.; Brown, Catherine

    2009-01-01

    This study examined if alcohol expectancies (assessed with the Comprehensive Effects of Alcohol–Brief Form) were prospectively related to negative consequences (assessed with the Rutgers Alcohol Problem Index) and if these associations varied by gender. Data were collected from 558 first-year college students at a university in the south-eastern United States as part of an intervention study conducted during their initial residence hall meetings of the fall semester of 2007. Only those studen...

  7. Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults

    OpenAIRE

    Cooper, Jennifer N.; Fried, Linda; Tepper, Ping; Barinas-Mitchell, Emma; Conroy, Molly B.; Evans, Rhobert W.; Brooks, Maria Mori; Woodard, Genevieve A.; Sutton-Tyrrell, Kim

    2013-01-01

    Recent data suggest excess circulating aldosterone promotes cardiometabolic decline. Weight loss may lower aldosterone levels, but little longitudinal data is available in normotensive adults. We aimed to determine if, independent of changes in sodium excretion, reductions in serum aldosterone are associated with favorable changes in obesity-related factors in normotensive overweight/obese young adults. We studied 285 overweight/obese young adult participants (body mass index (BMI) ≥ 25 and <...

  8. Serum levels of KL-6 reflect disease activity of interstitial pneumonia associated with ANCA-related vasculitis

    OpenAIRE

    Iwata, Yasunori; Wada, Takashi; Furuichi, Kengo; Kitagawa, Kiyoki; Kokubo, Satoshi; Kobayashi, Motoo; Sakai, Norihiko; Yoshimoto, Keiichi; Shimizu, Miho; Kobayashi, Kenichi; Yokoyama, Hitoshi

    2001-01-01

    Objective. KL-6 is reported to be excreted from the lung alveolar and bronchial epithelial cells and may be a good marker for monitoring disease activity of interstitial pneumonia. This study was designed to ascertain the clinical significance of serum KL-6 levels in interstitial pneumonia associated with anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis. Methods. Serum KL-6 levels were determined by an enzyme-linked immunosorbent assay. Patients. We examined 20 healthy subjects,...

  9. Comparing Measures of Racial/Ethnic Discrimination, Coping, and Associations with Health-Related Outcomes in a Diverse Sample

    OpenAIRE

    Benjamins, Maureen R.

    2013-01-01

    Discrimination is detrimental to health behaviors and outcomes, but little is known about which measures of discrimination are most strongly related to health, if relationships with health outcomes vary by race/ethnicity, and if coping responses moderate these associations. To explore these issues, the current study assessed race/ethnic differences in five measures of race/ethnic discrimination, as well as emotional and behavioral coping responses, within a population-based sample of Whites, ...

  10. Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

    OpenAIRE

    Okada, Yukinori; Sim, Xueling; Go, Min Jin; Wu, Jer-Yuarn; Gu, Dongfeng; Takeuchi, Fumihiko; Takahashi, Atsushi; Maeda, Shiro; Tsunoda, Tatsuhiko; Chen, Peng; Lim, Su-Chi; Wong, Tien-Yin; LIU, Jianjun; Young, Terri L; Aung, Tin

    2012-01-01

    Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis...

  11. Kick back and destroy the ride: Alcohol-related violence and associations with drinking patterns and delinquency in adolescence

    OpenAIRE

    Stafström Martin

    2007-01-01

    Abstract Aim To assess how drinking patterns and delinquency are associated with self-reported experiences of alcohol-related violence in an adolescent population. Population and research design Cross-sectional data were acquired from the Scania drug use survey 2005, consisting of 3847 students in 9th grade. Abstainers were omitted and 1873 responses analyzed, with binary and multi-variable logistic regression modeling. Results All drinking pattern indicators were statistically significantly ...

  12. Age-Related Macular Degeneration Is Associated with Less Physical Activity among US Adults: Cross-Sectional Study

    OpenAIRE

    Loprinzi, Paul D.; Swenor, Bonnielin K.; Ramulu, Pradeep Y.

    2015-01-01

    Background We have a limited understanding of the effects of age-related macular degeneration (AMD) on physical activity (PA), and we have no prevalence estimates of the daily movement patterns among Americans with AMD. Therefore, we examined the association between AMD and PA and provided estimates of the daily movement patterns of Americans with AMD. Methods Data from the 2005-2006 National Health and Nutrition Examination Survey were used, including 1,656 adults (40-85 yrs). Retinal imagin...

  13. Ethnic differences in the association of SERPING1 with age-related macular degeneration and polypoidal choroidal vasculopathy

    OpenAIRE

    Ke Liu; Lai, Timothy Y. Y.; Li Ma; Lai, Frank H. P.; Young, Alvin L.; Marten E. Brelen; Tam, Pancy O.S.; Chi Pui Pang; Li Jia Chen

    2015-01-01

    Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of irreversible blindness in developed countries. In this study, we investigated the association of single nucleotide polymorphisms (SNPs) in the serpin peptidase inhibitor, clade G, member 1 (SERPING1) gene with neovascular AMD and PCV. Two haplotype-tagging SNPs, rs1005510 and rs11603020, of SERPING1 were genotyped in 708 unrelated Chinese individuals: 200 neovascular AMD, 233 P...

  14. Association between Long-Term Exposure to Traffic-Related Air Pollution and Subclinical Atherosclerosis: The REGICOR Study

    OpenAIRE

    Rivera, Marcela; Basagaña, Xavier; Aguilera, Immaculada; Foraster, María; Agis, David; Groot, Eric de; Pérez, Laura; Méndez, Michelle A.; Bouso, Laura; TARGA Jaume; Ramos Blanes, Rafel; Sala, Joan; Marrugat, Jaume; Elosua, Roberto; Künzli, Nino

    2012-01-01

    Background: Epidemiological evidence of the effects of long-term exposure to air pollu tion on the chronic processes of athero genesis is limited. Objective: We investigated the association of long-term exposure to traffic-related air pollu tion with subclinical atherosclerosis, measured by carotid intima media thickness (IMT) and ankle–brachial index (ABI). Methods: We performed a cross-sectional analysis using data collected during the reexamination (2007–2010) of 2,780 participants in the...

  15. Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes

    OpenAIRE

    Hidetaka Hamasaki; Yu Kawashima; Hiroki Adachi; Sumie Moriyama; Hisayuki Katsuyama; Akahito Sako; Hidekatsu Yanai

    2015-01-01

    Background. Age-related loss of muscle mass (sarcopenia) increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of two sarcopenic indices, the ratio of lower extremity muscle mass to body weight (L/W ratio) and the ratio of lower extremity muscle mass to upper extremity muscle mass (L/U ratio), with metabolic p...

  16. Association between Cardiorespiratory Fitness and Health-Related Quality of Life among Patients at Risk for Cardiovascular Disease in Uruguay

    OpenAIRE

    Clennin, Morgan N.; Payne, Jonathan P.W.; Rienzi, Edgardo G.; Lavie, Carl J.; Blair, Steven N.; Pate, Russell R.; Sui, Xuemei

    2015-01-01

    To date, few studies have examined the relationship between cardiorespiratory fitness (CRF) and health-related quality of life (HRQoL) in populations at high risk for developing cardiovascular disease (CVD). Purpose To examine the association between objectively measured CRF and physical and mental components of HRQoL in a Uruguayan cohort at risk for developing CVD. Methods Patient data records from 2002–2012 at the Calidad de Vida Center were examined. To assess CRF, participants performed ...

  17. Association of sarcopenia with swallowing problems, related to nutrition and activities of daily living of elderly individuals

    OpenAIRE

    Shiozu, Hiroyasu; Higashijima, Misako; Koga, Tomoshige

    2015-01-01

    [Purpose] The purpose of the current study was to clarify problems associated with swallowing, related to nutrition and activities of daily living (ADL), in elderly individuals with sarcopenia. [Subjects and Methods] Seventy-seven subjects were assigned to a sarcopenia or a non-sarcopenia group according to a definition used by the European Working Group on Sarcopenia in Older People. Analyses were conducted including and excluding subjects with a central nervous system disorders in order to ...

  18. Comparing measures of racial/ethnic discrimination, coping, and associations with health-related outcomes in a diverse sample.

    Science.gov (United States)

    Benjamins, Maureen R

    2013-10-01

    Discrimination is detrimental to health behaviors and outcomes, but little is known about which measures of discrimination are most strongly related to health, if relationships with health outcomes vary by race/ethnicity, and if coping responses moderate these associations. To explore these issues, the current study assessed race/ethnic differences in five measures of race/ethnic discrimination, as well as emotional and behavioral coping responses, within a population-based sample of Whites, African Americans, Mexicans, and Puerto Ricans (n = 1,699). Stratified adjusted logistic regression models were run to examine associations between the discrimination measures and mental, physical, and health behavior outcomes and to test the role of coping. Overall, 86 % of the sample reported discrimination. Puerto Ricans were more likely than Mexicans and Whites to report most types of discrimination but less likely than Blacks. Discrimination was most strongly related to depression and was less consistently (or not) associated with physical health and health behaviors. Differences by measure of discrimination and respondent race/ethnicity were apparent. No support was found to suggest that coping responses moderate the association between discrimination and health. More work is needed to understand the health effects of this widespread social problem. In addition, interventions attempting to reduce health disparities need to take into account the influence of discrimination. PMID:23430374

  19. Aging-related gains and losses associated with word production in connected speech.

    Science.gov (United States)

    Dennis, Paul A; Hess, Thomas M

    2016-11-01

    Older adults have been observed to use more nonnormative, or atypical, words than younger adults in connected speech. We examined whether aging-related losses in word-finding abilities or gains in language expertise underlie these age differences. Sixty younger and 60 older adults described two neutral photographs. These descriptions were processed into word types, and textual analysis was used to identify interrupted speech (e.g., pauses), reflecting word-finding difficulty. Word types were assessed for normativeness, with nonnormative word types defined as those used by six (5%) or fewer participants to describe a particular picture. Accuracy and precision ratings were provided by another sample of 48 high-vocabulary younger and older adults. Older adults produced more interrupted and, as predicted, nonnormative words than younger adults. Older adults were more likely than younger adults to use nonnormative language via interrupted speech, suggesting a compensatory process. However, older adults' nonnormative words were more precise and trended for having higher accuracy, reflecting expertise. In tasks offering response flexibility, like connected speech, older adults may be able to offset instances of aging-related deficits by maximizing their expertise in other instances. PMID:26963869

  20. Conditioned Fear Associated Phenotypes as Robust, Translational Indices of Trauma-, Stressor-, and Anxiety-related Behaviors

    Directory of Open Access Journals (Sweden)

    Maria Anne Briscione

    2014-07-01

    Full Text Available Posttraumatic stress disorder (PTSD is a heterogeneous disorder that affects individuals exposed to trauma (e.g., combat, interpersonal violence, and natural disasters. It is characterized by hyperarousal, intrusive reminders of the trauma, avoidance of trauma-related cues, and negative cognition and mood. This heterogeneity indicates the presence of multiple neurobiological mechanisms underlying the development and maintenance of PTSD. Fear conditioning is a robust, translational experimental paradigm that can be employed to elucidate these mechanisms by allowing for the study of fear-related dimensions of PTSD (e.g., fear extinction, fear inhibition, and generalization of fear across multiple units of analysis. Fear conditioning experiments have identified varying trajectories of the dimensions described, highlighting exciting new avenues of targeted, focused study. Additionally, fear conditioning studies provide a translational platform to develop novel interventions. The current review highlights the versatility of fear conditioning paradigms, the implications for pharmacological and non-pharmacological treatments, the robustness of these paradigms to span an array of neuroscientific measures (e.g., genetic studies, and finally the need to understand the boundary conditions under which these paradigms are effective. Further understanding these paradigms will ultimately allow for optimization of fear conditioning paradigms, a necessary step towards the advancement of PTSD treatment methods.

  1. Association between cancer literacy and cancer-related behaviour: evidence from Ticino, Switzerland

    Directory of Open Access Journals (Sweden)

    Nicola Diviani

    2014-07-01

    Full Text Available Background. This paper details the role of different dimensions of health literacy in the relationship between health literacy and cancer-related health behaviours. In particular, Cancer Literacy is studied as an exemplar of a dimension of health literacy beyond basic reading and writing skills. The link between functional health literacy, Cancer Literacy and cancer-related health behaviours is investigated in a sample of Ticino (Switzerland residents (n=639. Design and methods. Detailed data is collected about respondents’ functional health literacy, Cancer Literacy, cancer information seeking behaviour, engagement in cancer preventive behaviours, participation to cancer screenings, and intention to adhere to current screening recommendations. Results. Results confirm the added value of Cancer Literacy – compared to functional health literacy – in explaining people’s cancer information seeking behaviour, their participation to several cancer screenings and their screening intention, underscoring the need to take into account dimensions of health literacy beyond basic functional skills. Conclusions. From a public health perspective, findings provide further evidence on the importance of adapting informational and educational communication intervention designed to improve cancer prevention and screening to different audiences.

  2. Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate

    Directory of Open Access Journals (Sweden)

    Shi-Long Yang

    2015-01-01

    Full Text Available Although Methotrexate (MTX is an effective drug for the treatment of acute lymphoblastic leukemia (ALL, the toxicity remains a significant problem. In this prospective study, fifty-four patients with ALL were enrolled. 3 g or 5 g MTX/m2 was administered over 24 hours. Serum MTX concentrations were determined in 24, 48, and 96 hours after MTX infusion. Serum creatinine concentrations and creatinine clearance rate (CCR were determined before and 24 and 48 hours after MTX infusion. A total of 173 courses of MTX infusion were administered. The serum creatinine concentrations did not change much after MTX infusion while the CCR was gradually decreased. MTX clearance status was independently related to CCR decrease, with the risk of 8.07 to develop renal impairment in patients with delayed MTX elimination. Serum creatinine concentration, serum creatinine ratio, CCR, and CCR ratio at 24 hours were all related to MTX elimination delay. Patients with serum creatinine level >35.0 μmol/L, creatinine ratio >1.129, or CCR <100.0 mL/min were more likely to undergo MTX elimination delay. In conclusion, MTX could induce transient renal impairment and compromised renal function will delay MTX clearance. The serum creatinine concentration and the ratio and CCR are useful tools for evaluating MTX elimination status.

  3. Yoga breathing through a particular nostril is associated with contralateral event-related potential changes

    Directory of Open Access Journals (Sweden)

    Shirley Telles

    2012-01-01

    Full Text Available Background: In earlier studies uninostril yoga breathing was shown to influence the activity of the cerebral hemispheres differently, based on (i auditory evoked potentials recorded from bilateral scalp sites, and (ii performance in hemisphere-specific tasks. But change in P300 (event-related potential generated when subjects attend to and discriminate between stimuli from bilateral scalp sites when subjects were practicing uni- and alternate-nostril breathing are yet to be explored. Aim: The present study was designed to determine whether or not immediately after uninostril or alternate nostril yoga breathing there would be a change in the ability to pay attention to a given stimulus. Materials and Methods: Twenty-nine healthy male volunteers, with ages between 20 and 45 years were randomly allocated to five sessions, viz., (i right-, (ii left-, (iii alternate-nostril yoga breathing, (iv breath awareness and (v no intervention, each for 45 min on separate days. The P300 event related potential was recorded using an auditory oddball paradigm from sites on the left (C3 and right (C4, referenced to linked earlobes, before and after each session. Results: Post-hoc analysis with Bonferroni adjustment showed that the P300 peak latency was significantly lower at C3 compared to that at C4, following right nostril yoga breathing (P<0.05. Conclusion: These results suggest that right nostril yoga breathing facilitates the activity of contralateral (left hemisphere, in the performance of the P300 task.

  4. Age-related difference in the effective neural connectivity associated with probabilistic category learning

    International Nuclear Information System (INIS)

    Although it is well known that explicit memory is affected by the deleterious changes in brain with aging, but effect of aging in implicit memory such as probabilistic category learning (PCL) is not clear. To identify the effect of aging on the neural interaction for successful PCL, we investigated the neural substrates of PCL and the age-related changes of the neural network between these brain regions. 23 young (age, 252 y; 11 males) and 14 elderly (673 y; 7 males) healthy subjects underwent FDG PET during a resting state and 150-trial weather prediction (WP) task. Correlations between the WP hit rates and regional glucose metabolism were assessed using SPM2 (Pdiff(37) = 142.47, P<0.005), Systematic comparisons of each path revealed that frontal crosscallosal and the frontal to parahippocampal connection were most responsible for the model differences (P<0.05). For the successful PCL, the elderly recruits the basal ganglia implicit memory system but MTL recruitment differs from the young. The inadequate MTL correlation pattern in the elderly is may be caused by the changes of the neural pathway related with explicit memory. These neural changes can explain the decreased performance of PCL in elderly subjects

  5. Associations between feed efficiency, sexual maturity and fertility-related measures in young beef bulls.

    Science.gov (United States)

    Fontoura, A B P; Montanholi, Y R; Diel de Amorim, M; Foster, R A; Chenier, T; Miller, S P

    2016-01-01

    The beef industry has emphasized the improvement of feed utilization, as measured by modeling feed intake through performance traits to calculate residual feed intake (RFI). Evidence supports an inverse relationship between feed efficiency and reproductive function. The objective of this study was to determine the relationship of reproductive assessments and RFI unadjusted (RFI(Koch)) or adjusted for body composition (RFI(us)) and the relationship among fertility-related parameters. In total, 34 crossbred bulls were housed together for 112 days of performance evaluation, followed by assessment of scrotum IR imaging, scrotal circumference, testes ultrasonography and semen quality parameters at 377±33.4 days of age. Bulls were slaughtered at 389±34.0 days of age, and analyses of carcass composition, biometrics and histomorphometry of the testis and epididymis were conducted. Bulls were grouped into two subpopulations based on divergence of RFI, and within each RFI model either by including 50% of the population (Halves, high and low RFI, n=17) or 20.6% extremes of the population (Tails, high and low RFI, n=7). The means of productive performance and fertility-related measures were compared through these categories. Pearson's correlation was calculated among fertility-related measures. In the Halves subpopulation of the RFI(us), sperm of low-RFI bulls had decreased progressive motility (47.30% v. 59.90%) and higher abundance of tail abnormalities (4.30% v. 1.80%) than that of high-RFI bulls. In the Tails subpopulation of the RFI(Koch), low RFI displayed less variation in the scrotum surface temperature (0.62°C v. 1.16°C), decreased testis echogenicity (175.50 v 198.00 pixels) and larger (60.90 v. 56.80 mm(2)) but less-developed seminiferous tubules than high-RFI bulls. The evaluation of fertility-related parameters indicated that a higher percentage of immature seminiferous tubules was correlated with occurrence of sperm with distal droplets (r=0.59), a larger

  6. Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.

    Science.gov (United States)

    Cooper, Jennifer N; Fried, Linda; Tepper, Ping; Barinas-Mitchell, Emma; Conroy, Molly B; Evans, Rhobert W; Mori Brooks, Maria; Woodard, Genevieve A; Sutton-Tyrrell, Kim

    2013-10-01

    Recent data suggest excess circulating aldosterone promotes cardiometabolic decline. Weight loss may lower aldosterone levels, but little longitudinal data is available in normotensive adults. We aimed to determine whether, independent of changes in sodium excretion, reductions in serum aldosterone are associated with favorable changes in obesity-related factors in normotensive overweight/obese young adults. We studied 285 overweight/obese young adult participants (body mass index ≥ 25 andsodium restriction on vascular health. Body weight, serum aldosterone, 24-h sodium and potassium excretion and obesity-related factors were measured at baseline, 6, 12 and 24 months. Weight loss was significant at 6 (7%), 12 (6%) and 24 months (4%; all Pleptin, insulin, homeostasis assessment of insulin resistance, heart rate, tonic cardiac sympathovagal balance and increases in adiponectin (all Psodium and potassium excretion. Weight loss and reductions in thigh intermuscular fat (intermuscular adipose tissue area; IMAT) were associated with decreases in aldosterone in the subgroup (n=98) with metabolic syndrome (MetS) at baseline (MetS × weight loss, P=0.04; MetS × change in IMAT, P=0.04). Favorable changes in obesity-related factors are associated with reductions in aldosterone in young adults with no risk factors besides excess weight, an important finding, given aldosterone's emergence as an important cardiometabolic risk factor. PMID:23657296

  7. Socio-demographic and health-related factors associated with cognitive impairment in the elderly in Taiwan

    Directory of Open Access Journals (Sweden)

    Chiu Herng-Chia

    2011-01-01

    Full Text Available Abstract Background Cognitive impairment is an age-related condition as the rate of cognitive decline rapidly increases with aging. It is especially important to better understand factors involving in cognitive decline for the countries where the older population is growing rapidly. The aim of this study was to examine the association between socio-demographic and health-related factors and cognitive impairment in the elderly in Taiwan. Methods We analysed data from 2119 persons aged 65 years and over who participated in the 2005 National Health Interview Survey. Cognitive impairment was defined as having the score of the Mini Mental State Examination lower than 24. The χ2 test and multiple logistic regression models were used to evaluate the association between cognitive impairment and variables of socio-demography, chronic diseases, geriatric conditions, lifestyle, and dietary factors. Results The prevalence of cognitive impairment was 22.2%. Results of multivariate analysis indicated that low education, being single, low social support, lower lipid level, history of stroke, physical inactivity, non-coffee drinking and poor physical function were associated with a higher risk of cognitive impairment. Conclusion Most of the characteristics in relation to cognitive impairment identified in our analysis are potentially modifiable. These results suggest that improving lifestyle behaviours such as regular exercise and increased social participation could help prevent or decrease the risk of cognitive impairment. Further investigations using longitudinal data are needed to clarify our findings.

  8. Characterization of Kaposi's Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis

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    Keiji Ueda

    2011-01-01

    Full Text Available Among herpesviruses, γ-herpesviruses are supposed to have typical oncogenic activities. Two human γ-herpesviruses, Epstein-Barr virus (EBV and Kaposi's sarcoma-associated herpesvirus (KSHV, are putative etiologic agents for Burkitt lymphoma, nasopharyngeal carcinoma, and some cases of gastric cancers, and Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma (PEL especially in AIDS setting for the latter case, respectively. Since such two viruses mentioned above are highly species specific, it has been quite difficult to prove their oncogenic activities in animal models. Nevertheless, the viral oncogenesis is epidemiologically and/or in vitro experimentally evident. This time, we investigated gene expression profiles of KSHV-oriented lymphoma cell lines, EBV-oriented lymphoma cell lines, and T-cell leukemia cell lines. Both KSHV and EBV cause a B-cell-originated lymphoma, but the gene expression profiles were typically classified. Furthermore, KSHV could govern gene expression profiles, although PELs are usually coinfected with KSHV and EBV.

  9. [Age-related dynamics of the maximum oxygen consumption associated with different regimens of locomotor activity].

    Science.gov (United States)

    Miakotnykh, V V; Khodasevich, L S; Ermakov, B A

    2011-01-01

    This study included a total of 234 practically healthy men at the age from 40 to 69 years differing in the regimen of daily locomotor activity. They were divided into 4 groups, each comprised of subjects ranged by age with a ten-year interval. Group 1 included former high-level athletes continuing active physical training, group 2 was comprised of former high-level athletes living a sedentary life style, group 3 consisted of subjects regularly engaged in health-giving physical exercises, and group 4 included subjects who were never engaged in physical exercises. The energy consumption by the members of all four groups was estimated when they were undergoing a stepwise increasing workload on the veloergometer measured with the help of a computerized diagnostic system. The results of the study indicate that the high oxygen consumption at a limiting load in the former high-level athletes is associated with the significant economization of basal metabolism and the reduction of oxygen consumption at rest. This mechanism accounts for the possibility to retain adequate physical activity of the organism up to the age of 70 years. PMID:21465775

  10. Association between pregnancy losses in women and risk of atherosclerotic disease in their relatives

    DEFF Research Database (Denmark)

    Ranthe, Mattis Flyvholm; Diaz, Lars Jorge; Behrens, Ida; Bundgaard, Henning; Simonsen, Jacob; Melbye, Mads; Boyd, Heather Allison

    2016-01-01

    women with pregnancies in 1977-2008, and their parents (>1 million) and brothers (>435 000). We followed parents for incident ischaemic heart disease (IHD), myocardial infarction (MI), and cerebrovascular infarction (CVI), and brothers for a broader combined atherosclerotic endpoint. Using Cox...... regression, we estimated hazard ratios (HRs) for each outcome by history of pregnancy loss in daughters/sisters. Overall, parents whose daughters had 1, 2, and ≥3 miscarriages had 1.01 [95% confidence interval (CI) 0.99-1.04], 1.07 (95% CI 1.02-1.11), and 1.10 (95% CI 1.02-1.19) times the rate of MI...... may have a common aetiologic mechanism. Women in families with atherosclerotic disease may be predisposed to pregnancy loss; conversely, pregnancy losses in first-degree relatives may have implications for atherosclerotic disease risk....

  11. The burden of motorcycle-related neuro-trauma in Ireland and associated helmet usage.

    LENUS (Irish Health Repository)

    Murphy, R K J

    2009-04-01

    Motorcycles represent less than 2% of the licensed vehicles but motorcyclists account for 12% of road deaths in Ireland. The British Road Safety Authority has introduced the Sharp programme, which hopes to save 50 lives in the U.K. each year alone by helping riders to choose the best-fitting and safest helmets. We evaluated the pattern of head injuries sustained by motorcyclists referred to the two neurosurgical centres Beaumont Hospital and Cork University Hospital in Ireland and ascertained if the new SHARP guidelines could be of benefit in reducing the burden of motorcycle related neurotrauma and disability in Ireland. Despite Ireland having mandatory helmet laws almost a quarter of our motorcyclists with traumatic brain injury were unhelmeted. A significant reduction in mortality and morbidity is predicted if all motorcyclists in Ireland were to wear helmets that satisfied the SHARP criteria.

  12. The association between Neovascular Age-related Macular Degeneration and Regulatory T cells in peripheral blood

    DEFF Research Database (Denmark)

    Madelung, Christopher Fugl; Falk, Mads; Sørensen, Torben Lykke

    2015-01-01

    PURPOSE: To investigate regulatory T cells (Tregs) and subsets of the Treg population in patients with neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: Twenty-one neovascular AMD cases and 12 age-matched controls without retinal pathology were selected. Patients were...... recruited from our outpatient retinal clinic. Control individuals were typically spouses. The diagnosis of neovascular AMD was confirmed using fluorescein and indocyaningreen angiography. Fresh venous blood was analyzed by flow cytometry using fluorochrome-conjugated antibodies to the Treg surface antigens...... CD4, CD25, CD127, CD45RA, and CD31. Main outcome measures were the percentage of CD25(high)CD127(low) Tregs, the percentage of CD45RA(+) naïve Tregs, and the percentage of CD31(+) recent thymic emigrant Tregs. RESULTS: Comparing patients with neovascular AMD to controls, no significant differences...

  13. Expression patterns of a circadian clock gene are associated with age-related polyethism in harvester ants, Pogonomyrmex occidentalis

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    Ingram Krista K

    2009-04-01

    Full Text Available Abstract Background Recent advances in sociogenomics allow for comparative analyses of molecular mechanisms regulating the development of social behavior. In eusocial insects, one key aspect of their sociality, the division of labor, has received the most attention. Age-related polyethism, a derived form of division of labor in ants and bees where colony tasks are allocated among distinct behavioral phenotypes, has traditionally been assumed to be a product of convergent evolution. Previous work has shown that the circadian clock is associated with the development of behavior and division of labor in honeybee societies. We cloned the ortholog of the clock gene, period, from a harvester ant (Pogonomyrmex occidentalis and examined circadian rhythms and daily activity patterns in a species that represents an evolutionary origin of eusociality independent of the honeybee. Results Using real time qPCR analyses, we determined that harvester ants have a daily cyclic expression of period and this rhythm is endogenous (free-running under dark-dark conditions. Cyclic expression of period is task-specific; foragers have strong daily fluctuations but nest workers inside the nest do not. These patterns correspond to differences in behavior as activity levels of foragers show a diurnal pattern while nest workers tend to exhibit continuous locomotor activity at lower levels. In addition, we found that foragers collected in the early fall (relative warm, long days exhibit a delay in the nightly peak of period expression relative to foragers collected in the early spring (relative cold, short days. Conclusion The association of period mRNA expression levels with harvester ant task behaviors suggests that the development of circadian rhythms is associated with the behavioral development of ants. Thus, the circadian clock pathway may represent a conserved 'genetic toolkit' that has facilitated the parallel evolution of age-related polyethism and task allocation in

  14. Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteins.

    Directory of Open Access Journals (Sweden)

    Nicholas J Hudson

    Full Text Available Codon bias in the genome of an organism influences its phenome by changing the speed and efficiency of mRNA translation and hence protein abundance. We hypothesized that differences in codon bias, either between-species differences in orthologous genes, or within-species differences between genes, may play an evolutionary role. To explore this hypothesis, we compared the genome-wide codon bias in six species that occupy vital positions in the Eukaryotic Tree of Life. We acquired the entire protein coding sequences for these organisms, computed the codon bias for all genes in each organism and explored the output for relationships between codon bias and protein function, both within- and between-lineages. We discovered five notable coordinated patterns, with extreme codon bias most pronounced in traits considered highly characteristic of a given lineage. Firstly, the Homo sapiens genome had stronger codon bias for DNA-binding transcription factors than the Saccharomyces cerevisiae genome, whereas the opposite was true for ribosomal proteins--perhaps underscoring transcriptional regulation in the origin of complexity. Secondly, both mammalian species examined possessed extreme codon bias in genes relating to hair--a tissue unique to mammals. Thirdly, Arabidopsis thaliana showed extreme codon bias in genes implicated in cell wall formation and chloroplast function--which are unique to plants. Fourthly, Gallus gallus possessed strong codon bias in a subset of genes encoding mitochondrial proteins--perhaps reflecting the enhanced bioenergetic efficiency in birds that co-evolved with flight. And lastly, the G. gallus genome had extreme codon bias for the Ciliary Neurotrophic Factor--which may help to explain their spontaneous recovery from deafness. We propose that extreme codon bias in groups of genes that encode functionally related proteins has a pathway-level energetic explanation.

  15. Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans.

    Science.gov (United States)

    Rahimi, Mehran; Vinciguerra, Manlio; Daghighi, Mojtaba; Özcan, Behiye; Akbarkhanzadeh, Vishtaseb; Sheedfar, Fareeba; Amini, Marzyeh; Mazza, Tommaso; Pazienza, Valerio; Motazacker, Mahdi M; Mahmoudi, Morteza; De Rooij, Felix W M; Sijbrands, Eric; Peppelenbosch, Maikel P; Rezaee, Farhad

    2015-10-01

    Despite numerous developed drugs based on glucose metabolism interventions for treatment of age-related diseases such as diabetes neuropathies (DNs), DNs are still increasing in patients with type 1 or type 2 diabetes (T1D, T2D). We aimed to identify novel candidates in adipose tissue (AT) and pancreas with T2D for targeting to develop new drugs for DNs therapy. AT-T2D displayed 15 (e.g. SYT4 up-regulated and VGF down-regulated) and pancreas-T2D showed 10 (e.g. BAG3 up-regulated, VAV3 and APOA1 down-regulated) highly differentially expressed genes with neuronal functions as compared to control tissues. ELISA was blindly performed to measure proteins of 5 most differentially expressed genes in 41 human subjects. SYT4 protein was upregulated, VAV3 and APOA1 were down-regulated, and BAG3 remained unchanged in 1- Obese and 2- Obese-T2D without insulin, VGF protein was higher in these two groups as well as in group 3- Obese-T2D receiving insulin than 4-lean subjects. Interaction networks analysis of these 5 genes showed several metabolic pathways (e.g. lipid metabolism and insulin signaling). Pancreas is a novel site for APOA1 synthesis. VGF is synthesized in AT and could be considered as good diagnostic, and even prognostic, marker for age-induced diseases obesity and T2D. This study provides new targets for rational drugs development for the therapy of age-related DNs. PMID:26337083

  16. Anxiety and its related factors at bedtime are associated with difficulty in falling asleep.

    Science.gov (United States)

    Narisawa, Hajime

    2013-01-01

    Insomnia is a sleep disorder that is marked by difficulty in falling asleep, difficulty in maintaining sleep, and/or early morning awakening. Difficulty in falling asleep is particularly common in young adults, and sleep onset is affected by psychological factors. The purpose of the present study was to identify the physical and mental factors related to the subjective evaluation of falling asleep among Japanese university students. The participants were 366 students, including 197 (53.8%) females, with a mean age of 20.6 ± 1.7 years. The questionnaire battery mainly covered items about sleep onset, sleep quality, trait anxiety, and general mental state. Sleep onset was categorized as "easy to achieve" for 121 (33.1%) subjects, "difficult" for 38 (10.4%), and "intermediate" for 207 (56.6%). For example, "difficult" was defined as taking a longer time to fall asleep. The subjects with difficult sleep onset reported significantly higher awareness of the smell and noises in the bedroom, body sensations such as a heavy stomach feeling and frequent rolling over, mental agitation and excitement, unstable mental state, negative state, and strain. The subjects with difficult sleep onset also showed less sleep comfort and less recovery from fatigue. A multinominal logistic regression analysis revealed that each of body sensation, sleep comfort, unstable mental state, and fatigue influenced whether an individual had the difficult type. Anxiety-related factors at bedtime, in particular, may delay the sleep onset. The results of the present study indicate that many university students may be at risk of sleep-onset insomnia. PMID:24005330

  17. Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México

    Science.gov (United States)

    Hernandez-Escalante, Victor M.; Nava-Gonzalez, Edna J.; Voruganti, V. Saroja; Kent, Jack W.; Haack, Karin; Laviada-Molina, Hugo A.; Molina-Segui, Fernanda; Gallegos-Cabriales, Esther C.; Lopez-Alvarenga, Juan Carlos; Cole, Shelley A.; Mezzles, Marguerite J.; Comuzzie, Anthony G.; Bastarrachea, Raul A.

    2014-01-01

    The prevalence of type 2 diabetes (T2D) is rising rapidly and in Mexicans is ~19%. T2D is affected by both environmental and genetic factors. Although specific genes have been implicated in T2D risk few of these findings are confirmed in studies of Mexican subjects. Our aim was to replicate associations of 39 single nucleotide polymorphisms (SNPs) from 10 genes with T2D-related phenotypes in a community-based Mexican cohort. Unrelated individuals (n = 259) living in southeastern Mexico were enrolled in the study based at the University of Yucatan School of Medicine in Merida. Phenotypes measured included anthropometric measurements, circulating levels of adipose tissue endocrine factors (leptin, adiponectin, pro-inflammatory cytokines), and insulin, glucose, and blood pressure. Association analyses were conducted by measured genotype analysis implemented in SOLAR, adapted for unrelated individuals. SNP Minor allele frequencies ranged from 2.2 to 48.6%. Nominal associations were found for CNR1, SLC30A8, GCK, and PCSK1 SNPs with systolic blood pressure, insulin and glucose, and for CNR1, SLC30A8, KCNJ11, and PCSK1 SNPs with adiponectin and leptin (p < 0.05). P-values greater than 0.0014 were considered significant. Association of SNPs rs10485170 of CNR1 and rs5215 of KCNJ11 with adiponectin and leptin, respectively, reached near significance (p = 0.002). Significant association (p = 0.001) was observed between plasma leptin and rs5219 of KCNJ11. PMID:25477898

  18. HBV-related hepatocellular carcinoma susceptibility gene KIF1B is not associated with development of chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Rong Zhong

    Full Text Available BACKGROUND: A recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B, strongly associated with progression from chronic hepatitis B (CHB to hepatitis B virus-related hepatocellular carcinoma (HCC in Chinese population, this study was carried out to explore the role of the genetic variants in KIF1B in the development of chronic hepatitis B. METHODOLOGY/PRINCIPAL FINDINGS: Three KIF1B polymorphisms (rs8019, rs17401924, and rs17401966 were selected and genotyped in 473 CHB patients and 580 controls with no history of CHB. Odds ratios (ORs and 95% confidence intervals (CIs were calculated by logistic regression model. None of these three SNPs showed association with CHBs after adjusting for age and gender. Equivalence-based method analysis confirmed the absence of association. In the further haplotype analysis, three common haplotypes were observed in this study population, but no significant effect was also found for haplotypes in the progression to CHB. CONCLUSIONS/SIGNIFICANCE: This study showed the new locus identified for HCC, KIF1B, was not associated with progression to CHB, implying distinct genetic susceptibility factor contributes to the progression from hepatitis B virus infection to HCC. Nevertheless, further comprehensive analyses are warranted to dissect the mechanism.

  19. Using naturalistic driving data to explore the association between traffic safety-related events and crash risk at driver level.

    Science.gov (United States)

    Wu, Kun-Feng; Aguero-Valverde, Jonathan; Jovanis, Paul P

    2014-11-01

    There has been considerable research conducted over the last 40 years using traffic safety-related events to support road safety analyses. Dating back to traffic conflict studies from the 1960s these observational studies of driver behavior have been criticized due to: poor quality data; lack of available and useful exposure measures linked to the observations; the incomparability of self-reported safety-related events; and, the difficulty in assessing culpability for safety-related events. This study seeks to explore the relationships between driver characteristics and traffic safety-related events, and between traffic safety-related events and crash involvement while mitigating some of those limitations. The Virginia Tech Transportation Institute 100-Car Naturalistic Driving Study dataset, in which the participants' vehicles were instrumented with various cameras and sensors during the study period, was used for this study. The study data set includes 90 drivers observed for 12-13 months driving. This study focuses on single vehicle run-off-road safety-related events only, including 14 crashes and 182 safety-related events (30 near crashes, and 152 crash-relevant incidents). Among the findings are: (1) drivers under age 25 are significantly more likely to be involved in safety-related events and crashes; and (2) significantly positive correlations exist between crashes, near crashes, and crash-relevant incidents. Although there is still much to learn about the factors affecting the positive correlation between safety-related events and crashes, a Bayesian multivariate Poisson log-normal model is shown to be useful to quantify the associations between safety-related events and crash risk while controlling for driver characteristics. PMID:25086439

  20. Treatment of fragile X-associated tremor ataxia syndrome (FXTAS and related neurological problems

    Directory of Open Access Journals (Sweden)

    Randi J Hagerman

    2008-06-01

    Full Text Available Randi J Hagerman1,2, Deborah A Hall3, Sarah Coffey1,2, Maureen Leehey3, James Bourgeois4, John Gould5, Lin Zhang6, Andreea Seritan4, Elizabeth Berry-Kravis7–9, John Olichney6, Joshua W Miller10, Amy L Fong11, Randall Carpenter12, Cathy Bodine13, Louise W Gane1,2, Edgar Rainin1, Hillary Hagerman1, Paul J Hagerman141M.I.N.D. Institute, 2Department of Pediatrics, 4Department of Psychiatry & Behavioral Sciences, 5Department of Urology, 6Department of Neurology, 10Department of Pathology and Laboratory Medicine, 14Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA, USA; 3Department of Neurology, University of Colorado, Denver, CO, USA; 7Department of Pediatrics, Neurology, and Biochemistry, 8Department of Neurological Sciences, 9Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA; 11Physical Edge, Inc., Davis, CA, USA; 12Seaside Therapeutics, Cambridge, MA, USA; 13Department of Physical Medicine and Rehabilitation, University of Colorado Health Sciences Center, Denver, CO, USAAbstract: Fragile X-associated tremor/ataxia syndrome (FXTAS is a progressive neurological disorder that affects older adult carriers, predominantly males, of premutation alleles (55 to 200 CGG repeats of the fragile X (FMR1 gene. Principal features of FXTAS are intention tremor, ataxia, parkinsonism, cognitive decline, and peripheral neuropathy; ancillary features include, autonomic dysfunction, and psychiatric symptoms of anxiety, depression, and disinhibition. Although controlled trials have not been carried out in individuals with FXTAS, there is a significant amount of anecdotal information regarding various treatment modalities. Moreover, there exists a great deal of evidence regarding the efficacy of various medications for treatment of other disorders (eg, Alzheimer disease that have substantial phenotypic overlap with FXTAS. The current review summarizes what is currently

  1. Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option.

    OpenAIRE

    Moseley, P.; Fernyhough, C.; Ellison, A.

    2013-01-01

    Auditory verbal hallucinations (AVHs) are the experience of hearing voices in the absence of any speaker, often associated with a schizophrenia diagnosis. Prominent cognitive models of AVHs suggest they may be the result of inner speech being misattributed to an external or non-self source, due to atypical self- or reality monitoring. These arguments are supported by studies showing that people experiencing AVHs often show an externalising bias during monitoring tasks, and neuroimaging eviden...

  2. IgG4-Related Lung Disease Associated with Usual Interstitial Pneumonia.

    Science.gov (United States)

    Schneider, Frank; Veraldi, Kristen L; Levesque, Marc C; Colby, Thomas V; S Yi, Eunhee

    2016-01-01

    We report a case of immunoglobulin(Ig)G4-related disease with the radiologic and histopathological manifestations resembling usual interstitial pneumonia (UIP). The patient was a 62-year-old man who presented with progressive dyspnea of insidious onset. High resolution computed tomography of the chest showed lower-lobe predominant peripheral reticulation and traction bronchiectasis but no honeycomb change. Microscopic examination of the surgical lung biopsy showed characteristic features of UIP including architectural distortion by fibrosis with peripheral and paraseptal accentuation, scattered fibroblast foci and microscopic honeycomb change. In addition there were prominent multifocal lymphoplasmacytic infiltrates with a marked increase of IgG4-positive plasma cells (79 per high power field in hot spots) and high IgG4/IgG ratio (up to 67%). The serum IgG4 level was elevated at 760 mg/dl (reference range 9-89), with normal levels for the other IgG subclasses and negative serologic markers for autoimmune diseases. The patient's symptoms improved significantly with oral corticosteroid treatment. PMID:27053971

  3. Understanding of School Related Factors Associated with Emotional Health and Bullying Behavior among Jordanian Adolescents.

    Directory of Open Access Journals (Sweden)

    Abeer Shaheen

    2014-11-01

    Full Text Available Students emotional health and bullying behavior are receiving greater attention worldwide due to their long-term effects on students' health. The purpose of this study was to examine the relationships between perceived school climate, peer support, teacher support, school pressure and emotional health and bullying among adolescent school students in Jordan.A cross-sectional descriptive design was used to recruit a sample of 1166 in-school adolescents in Amman between November 2013 and January 2014. A multi-stage cluster sampling technique was used to select respondents and Health Behavior in School Aged Children questionnaire was used to collect the data. Data were analyzed using Pearson Correlation to detect relationships among study variables.Significant correlations (P value was ≤.05 were found between school climate including teacher and peer support and emotional health and bullying behavior of school students. School pressure was not correlated significantly with emotional health and bullying.Study findings emphasize the importance of school related factors in influencing students' emotional health and bullying behavior. This indicates that the issue of bullying and emotional health of students in Jordanian schools requires further attention, both for future research and preventive intervention.

  4. Cognitive and Behavioral Factors Associated With Insomnia in Inpatients With Schizophrenia and Related Psychoses.

    Science.gov (United States)

    Chiu, Vivian W; Harvey, Robert H; Sloan, Nancy B; Ree, Melissa; Lin, Ashleigh; Janca, Aleksandar; Waters, Flavie

    2015-10-01

    This study examines cognitive and behavioral factors linked to insomnia in individuals with schizophrenia and other psychotic disorders (with and without insomnia) and healthy controls (with and without insomnia). Fifty-five psychiatric inpatients and 66 healthy controls (n = 25 with insomnia in both groups) completed the Insomnia Severity Index, Thought Control Questionnaire for Insomnia-Revised, Dysfunctional Beliefs and Attitudes about Sleep scale, Sleep Hygiene Knowledge scale, and Beliefs about Causes of Sleep Problems questionnaires. Both insomnia groups demonstrated night-time rumination, aggressive suppression as a thought control strategy, and exaggerated views regarding the health consequences of poor sleep. In addition, the psychiatric group with insomnia frequently reported the causes of insomnia to be related to their illness (rather than to their lifestyle factors) and had an incomplete understanding of good sleep habits. Psychological interventions should be more commonly pursued as a first line of treatment for insomnia in schizophrenia and psychosis, and these should be adapted to address the unique knowledge gaps and cognitive style of patients. PMID:26356092

  5. Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.

    Science.gov (United States)

    Fuhrman-Luck, Ruth A; Stansfield, Scott H; Stephens, Carson R; Loessner, Daniela; Clements, Judith A

    2016-08-01

    Prostate cancer metastasis to bone is terminal; thus, novel therapies are required to prevent end-stage disease. Kallikrein-related peptidase 4 (KLK4) is a serine protease that is overproduced in localized prostate cancer and is abundant in prostate cancer bone metastases. In vitro, KLK4 induces tumor-promoting phenotypes; however, the underlying proteolytic mechanism is undefined. The protein topography and migration analysis platform (PROTOMAP) was used for high-depth identification of KLK4 substrates secreted by prostate cancer bone metastasis-derived PC-3 cells to delineate the mechanism of KLK4 action in advanced prostate cancer. Thirty-six putative novel substrates were determined from the PROTOMAP analysis. In addition, KLK4 cleaved the established substrate, urokinase-type plasminogen activator, thus validating the approach. KLK4 activated matrix metalloproteinase-1 (MMP1), a protease that promotes prostate tumor growth and metastasis. MMP1 was produced in the tumor compartment of prostate cancer bone metastases, highlighting its accessibility to KLK4 at this site. KLK4 further liberated an N-terminal product, with purported angiogenic activity, from thrombospondin-1 (TSP1) and cleaved TSP1 in an osteoblast-derived matrix. This is the most comprehensive analysis of the proteolytic action of KLK4 in an advanced prostate cancer model to date, highlighting KLK4 as a potential multifunctional regulator of prostate cancer progression. PMID:27378148

  6. Association among obesity-related anthropometric phenotypes: analyzing genetic and environmental contribution.

    Science.gov (United States)

    Jelenkovic, Aline; Rebato, Esther

    2012-04-01

    Obesity has become a public-health and policy problem in many parts of the world. Epidemiological and population studies in this field are usually based on different anthropometric measures; however, common genetic and environmental factors between these phenotypes have been scarcely studied. The objective of this article is to assess the strength of these factors on the covariation among a large set of obesity-related traits. The subject group consisted of 533 nuclear families living in the Greater Bilbao (Spain), and included 1,702 individuals aged 2-61 years. Detailed anthropometric measurements (stature, breadths, circumferences and skinfolds) were carried out in each subject. Bivariate quantitative genetic analyses were performed using a variance-components procedure implemented in the software SOLAR. The results revealed that the majority of these traits is affected by common genetic and environmental factors. All correlations were significantly different from 1 and varied from non-significant to very high (>0.90, P influence on the local fatness measures that cannot be explained exclusively by the genetic influence on overall fatness. Moreover, the observed relationships confirm a partially different genetic control of truncal and peripheral fat. In conclusion, our findings highlight the relevance of considering different types of traits in the prevention and treatment of obesity, as well as in the search for genes involved in its development. PMID:22708817

  7. Work- and nonwork-related factors associated with PACU nurses' fatigue.

    Science.gov (United States)

    Hazzard, Beatrice; Johnson, Karen; Dordunoo, Dzifa; Klein, Trisha; Russell, Brittany; Walkowiak, Patricia

    2013-08-01

    The purpose of this study was to describe postanesthesia care unit (PACU) nurses' fatigue and link fatigue levels to work- and nonwork-related factors. The study design is a pilot study using a descriptive correlation design. Participants used a 4-week daily diary to record hours worked, breaks taken, and sleep patterns and completed the Occupational Fatigue Exhaustion Recovery Scale (OFER). The sample included 20 experienced (17.3 ± 9.5 years) nurses. Only 4% reported no breaks during their shift. Median sleep time was 6 hours 40 minutes. OFER scores were acute fatigue (66.5 ± 19.3), intershift fatigue (52 ± 18.6), and chronic fatigue (35.7 ± 17.2). In conclusion, acute fatigue scores reflect the challenges of working in the PACU. Despite high acute fatigue scores, intershift fatigue scores reflected recovery and chronic fatigue scores were low. Fatigue reduction strategies may account for these results including processes to ensure breaks are taken, use of a flex shift nurse to prevent shift overruns, and reduction of the number of three consecutive 12-hour shifts. PMID:23886284

  8. Is low back pain associated with worse health-related quality of life 6 months later?

    DEFF Research Database (Denmark)

    Nolet, P. S.; Kristman, V. L.; Cote, P.; Carroll, L. J.; Cassidy, J.

    2015-01-01

    The purpose of this study was to investigate the impact of low back pain (LBP) on future health-related quality of life (HRQoL). Current evidence suggests that individuals with LBP have poorer HRQoL than those without LBP. However, most of the evidence comes from cross-sectional studies where LBP......, income, arthritis, neck pain, and kidney disorders: grade III-IV LBP (beta = -10.23; 95 % CI -12.46, -7.99), grade II LBP (beta = -6.72, 95 % CI -8.79, -4.65), and grade I LBP (beta = -1.77; 95 % CI -3.18, -0.36). There was no dose-response relationship between LBP and mental HRQoL at 6 months. Low back...... control of known confounders. We formed a cohort of 1,110 randomly sampled Saskatchewan adults in September 1995. LBP at baseline was measured with the chronic pain questionnaire. The SF-36 questionnaire was used to measure physical and mental HRQoL at 6 months follow-up. Multivariable linear regression...

  9. Characteristics and management of immune-related adverse effects associated with ipilimumab, a new immunotherapy for metastatic melanoma

    Directory of Open Access Journals (Sweden)

    Andrews S

    2012-09-01

    Full Text Available Stephanie Andrews,1 Rita Holden21H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 2St Luke's Hospital and Health Network Cancer Center, Easton, PA, USAAbstract: When diagnosed in its early stages, melanoma is highly treatable and associated with good long-term outcomes; however, the prognosis is much poorer for patients diagnosed with advanced or metastatic melanoma. For decades, available treatments were effective in only a few patients and associated with significant safety concerns. Ipilimumab is a novel immunotherapy which has proved to be an exciting breakthrough in the treatment of melanoma. It is the first drug approved for the treatment of melanoma by the Food and Drug Administration (FDA which has shown a survival benefit in a randomized Phase III clinical trial. The objective of this review is to provide information on the administration, treatment responses, and expected outcomes of treatment of metastatic melanoma with the new immunotherapeutic agent, ipilimumab, a drug with a unique mechanism of action that differentiates it from current treatments. Guidelines for the management of immune-related adverse events associated with ipilimumab therapy are also presented. These stress vigilance, prompt intervention, and the use of corticosteroids as appropriate. Various ipilimumab-associated immune-related adverse events, both common (enterocolitis, dermatitis and less frequent (hepatitis, hypophysitis, are illustrated in case studies. Nurses are uniquely positioned to provide patient and caregiver education on how this new therapy differs from traditional cytotoxic agents, to recognize the signs and symptoms of immune-related adverse events, and to report them immediately, and finally, to be aware of the patterns of response that are commonly observed in patients receiving ipilimumab therapy.Keywords: melanoma, ipilimumab, immunotherapy, case studies

  10. B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination

    Science.gov (United States)

    Kothur, Kavitha; Wienholt, Louise; Tantsis, Esther M; Earl, John; Bandodkar, Sushil; Prelog, Kristina; Tea, Fiona; Ramanathan, Sudarshini; Brilot, Fabienne; Dale, Russell C.

    2016-01-01

    Background Myelin oligodendrocyte glycoprotein antibody (MOG Ab) associated demyelination represents a subgroup of autoimmune demyelination that is separate from multiple sclerosis and aquaporin 4 IgG-positive NMO, and can have a relapsing course. Unlike NMO and MS, there is a paucity of literature on immunopathology and CSF cytokine/chemokines in MOG Ab associated demyelination. Aim To study the differences in immunopathogenesis based on cytokine/chemokine profile in MOG Ab-positive (POS) and -negative (NEG) groups. Methods We measured 34 cytokines/chemokines using multiplex immunoassay in CSF collected from paediatric patients with serum MOG Ab POS [acute disseminated encephalomyelitis (ADEM = 8), transverse myelitis (TM = 2) n = 10] and serum MOG Ab NEG (ADEM = 5, TM = 4, n = 9) demyelination. We generated normative data using CSF from 20 non-inflammatory neurological controls. Results The CSF cytokine and chemokine levels were higher in both MOG Ab POS and MOG Ab NEG demyelination groups compared to controls. The CSF in MOG Ab POS patients showed predominant elevation of B cell related cytokines/chemokines (CXCL13, APRIL, BAFF and CCL19) as well as some of Th17 related cytokines (IL-6 AND G-CSF) compared to MOG Ab NEG group (all p<0.01). In addition, patients with elevated CSF MOG antibodies had higher CSF CXCL13, CXCL12, CCL19, IL-17A and G-CSF than patients without CSF MOG antibodies. Conclusion Our findings suggest that MOG Ab POS patients have a more pronounced CNS inflammatory response with elevation of predominant humoral associated cytokines/chemokines, as well as some Th 17 and neutrophil related cytokines/chemokines suggesting a differential inflammatory pathogenesis associated with MOG antibody seropositivity. This cytokine/chemokine profiling provides new insight into disease pathogenesis, and improves our ability to monitor inflammation and response to treatment. In addition, some of these molecules may represent potential immunomodulatory targets

  11. The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

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    Amanda Vansan Marangon

    2013-01-01

    Full Text Available The genetic variability of the host contributes to the risk of human papillomavirus (HPV-related cervical disease. Immune response genes to HPV must be investigated to define patients with the highest risk of developing malignant disease. The aim of this study was to investigate the association of polymorphic immune response genes, namely KIR, HLA class I and II, and single-nucleotide polymorphisms (SNPs of cytokines with HPV-related cervical disease. We selected 79 non-related, admixed Brazilian women from the state of Paraná, southern region of Brazil, who were infected with high carcinogenic risk HPV and present cervical intraepithelial neoplasia grade 3 (CIN3, and 150 HPV-negative women from the same region matched for ethnicity. KIR genes were genotyped using an in-house PCR-SSP. HLA alleles were typed using a reverse sequence-specific oligonucleotide technique. SNPs of TNF −308G>A, IL6 −174G>C, IFNG +874T>A, TGFB1 +869T>C +915G>C, and IL10 −592C>A −819C>T −1082G>A were evaluated using PCR-SSP. The KIR genes were not associated with HPV, although some pairs of i(inhibitoryKIR-ligands occurred more frequently in patients, supporting a role for NK in detrimental chronic inflammatory and carcinogenesis. Some HLA haplotypes were associated with HPV. The associations of INFG and IL10 SNPs potentially reflect impaired or invalid responses in advanced lesions.

  12. B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination.

    Directory of Open Access Journals (Sweden)

    Kavitha Kothur

    Full Text Available Myelin oligodendrocyte glycoprotein antibody (MOG Ab associated demyelination represents a subgroup of autoimmune demyelination that is separate from multiple sclerosis and aquaporin 4 IgG-positive NMO, and can have a relapsing course. Unlike NMO and MS, there is a paucity of literature on immunopathology and CSF cytokine/chemokines in MOG Ab associated demyelination.To study the differences in immunopathogenesis based on cytokine/chemokine profile in MOG Ab-positive (POS and -negative (NEG groups.We measured 34 cytokines/chemokines using multiplex immunoassay in CSF collected from paediatric patients with serum MOG Ab POS [acute disseminated encephalomyelitis (ADEM = 8, transverse myelitis (TM = 2 n = 10] and serum MOG Ab NEG (ADEM = 5, TM = 4, n = 9 demyelination. We generated normative data using CSF from 20 non-inflammatory neurological controls.The CSF cytokine and chemokine levels were higher in both MOG Ab POS and MOG Ab NEG demyelination groups compared to controls. The CSF in MOG Ab POS patients showed predominant elevation of B cell related cytokines/chemokines (CXCL13, APRIL, BAFF and CCL19 as well as some of Th17 related cytokines (IL-6 AND G-CSF compared to MOG Ab NEG group (all p<0.01. In addition, patients with elevated CSF MOG antibodies had higher CSF CXCL13, CXCL12, CCL19, IL-17A and G-CSF than patients without CSF MOG antibodies.Our findings suggest that MOG Ab POS patients have a more pronounced CNS inflammatory response with elevation of predominant humoral associated cytokines/chemokines, as well as some Th 17 and neutrophil related cytokines/chemokines suggesting a differential inflammatory pathogenesis associated with MOG antibody seropositivity. This cytokine/chemokine profiling provides new insight into disease pathogenesis, and improves our ability to monitor inflammation and response to treatment. In addition, some of these molecules may represent potential immunomodulatory targets.

  13. [Influenza-related respiratory illnesses and associated causes among the elderly in a city in Northeast Brazil].

    Science.gov (United States)

    Gomes, Aline de Andrade; Nunes, Marco Antônio Prado; Oliveira, Cristiane Costa da Cunha; Lima, Sônia Oliveira

    2013-01-01

    Nationwide influenza vaccination campaigns are held annually in Brazil during the same time of the year. This study aimed to analyze deaths from respiratory illnesses and influenza-related causes among the elderly in the city of Aracaju, capital of Sergipe State, Brazil. Data were analyzed from the following databases: Information System on Influenza Epidemiological Surveillance (SIVEP_GRIPE), Hospital Information System (SIH), Mortality Information System (SIM), and Health Informatics Department (DATASUS), from 1998 to 2007, Sergipe State Central Laboratory (LACEN-SE), and rainfall data from the National Meteorology Institute (INMET). The year 2007 showed the highest mortality rate from influenza and related causes in elderly individuals. From 1998 to 2007, mortality rates from influenza-related respiratory illnesses and associated causes in Aracaju city were higher than in the States of Brazil, indicating the need to reformulate the influenza vaccination schedule in elderly residents of this city. PMID:23370031

  14. Association of polypharmacy with fall-related fractures in older Taiwanese people: age- and gender-specific analyses

    Science.gov (United States)

    Pan, Hsueh-Hsing; Li, Chung-Yi; Chen, Tzeng-Ji; Su, Tung-Ping; Wang, Kwua-Yun

    2014-01-01

    Objective To elucidate the associations between polypharmacy and age- and gender-specific risks of admission for fall-related fractures. Design Nested case–control study. Setting This analysis was randomly selected from all elderly beneficiaries in 2007–2008, and represents some 30% of the whole older insurers using Taiwan's National Health Insurance Research Database. Participants We identified 5933 cases newly admitted for fall-related fractures during 2007–2008, and 29 665 random controls free from fracture. Primary and secondary outcome measures Polypharmacy was defined as the use of fall-related drugs of four or more categories of medications and prescribed related to fall within a 1-year period. Logistic regression models were employed to estimate the ORs and related 95% CIs. The interaction of polypharmacy with age and sex was assessed separately. Results Compared with those who consumed no category of medication, older people who consumed 1, 2, 3 and ≥4 categories of medications were all at significantly increased odds of developing fall-related fractures, with a significant dose–gradient pattern (β=0.7953; p for trend <0.0001). There were significant interactions between polypharmacy and age, but no significant interactions between polypharmacy and gender. The dose–gradient relationship between number of medications category and risk of fall-related fractures was more obvious in women than in men (β=0.1962 vs β=0.1873). Additionally, it was most evident in older people aged 75–84 years (β=0.2338). Conclusions This population-based study in Taiwan confirms the link between polypharmacy and increased risk of fall-related fractures in older people; and highlights that elderly women and older people aged 75–84 years will be the targeted participants for further prevention from fall-related fractures caused by polypharmacy. PMID:24682575

  15. Association of theory of mind with social relations and child's social competence

    Directory of Open Access Journals (Sweden)

    Nuša Skubic

    2012-10-01

    Full Text Available The article reviews and evaluates the findings from the research in the field of theory of mind; how the theory of mind is connected to social relationships and how a child's social competence reflects his/hers theory of mind. It points to those factors that contribute most to considerable individual differences among children when developing a theory of mind and it stresses out the reciprocity of effects between child's social understanding and social relations with others. Positive factors for developing a theory of mind are first of all child's early quality experiences about mental states which predict a child's performance on the false belief test later on. Social-economic status, parental behavior and talk (for example appropriate use of mental states and appropriate disciplining of a child and presence of sibling of appropriate age (usually older one with whom a child develops a quality relationship are most important family factors for theory of mind development. The role of peers is most important factor outside the family, emphasized by studies. In accordance with these factors a child develops more or less successfully his/hers social understanding which plays an important part in his/hers daily life. Children with well developed theory of mind can use it in a pro-social way, or it can serve proactive or reactive aggression when children use their understanding of others as a way of manipulating and bullying, especially inside their peer group. Poorly developed theory of mind can prove to be a risk factor especially in a bad family situation, while a well developed theory of mind can play a protective role in child's development. The article points out some of the deficiencies of reviewed studies and proposes options for more complex future research of child's theory of mind.

  16. Relative abundance of and composition within fungal orders differ between cheatgrass (Bromus tectorum and sagebrush (Artemisia tridentate-associated soils.

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    Carolyn F Weber

    Full Text Available Nonnative Bromus tectorum (cheatgrass is decimating sagebrush steppe, one of the largest ecosystems in the Western United States, and is causing regional-scale shifts in the predominant plant-fungal interactions. Sagebrush, a native perennial, hosts arbuscular mycorrhizal fungi (AMF, whereas cheatgrass, a winter annual, is a relatively poor host of AMF. This shift is likely intertwined with decreased carbon (C-sequestration in cheatgrass-invaded soils and alterations in overall soil fungal community composition and structure, but the latter remain unresolved. We examined soil fungal communities using high throughput amplicon sequencing (ribosomal large subunit gene in the 0-4 cm and 4-8 cm depth intervals of six cores from cheatgrass- and six cores from sagebrush-dominated soils. Sagebrush core surfaces (0-4 cm contained higher nitrogen and total C than cheatgrass core surfaces; these differences mirrored the presence of glomalin related soil proteins (GRSP, which has been associated with AMF activity and increased C-sequestration. Fungal richness was not significantly affected by vegetation type, depth or an interaction of the two factors. However, the relative abundance of seven taxonomic orders was significantly affected by vegetation type or the interaction between vegetation type and depth. Teloschistales, Spizellomycetales, Pezizales and Cantharellales were more abundant in sagebrush libraries and contain mycorrhizal, lichenized and basal lineages of fungi. Only two orders (Coniochaetales and Sordariales, which contain numerous economically important pathogens and opportunistic saprotrophs, were more abundant in cheatgrass libraries. Pleosporales, Agaricales, Helotiales and Hypocreales were most abundant across all libraries, but the number of genera detected within these orders was as much as 29 times lower in cheatgrass relative to sagebrush libraries. These compositional differences between fungal communities associated with cheatgrass

  17. Les relations entre syndicats et associations en Belgique : Le cas de la réforme du minimex Relations between Trade Unions and Other Voluntary Associations in Belgium with Special Reference to Basic Income.

    Directory of Open Access Journals (Sweden)

    Jean Faniel

    2011-03-01

    Full Text Available L’auteur se penche sur les relations entre organisations syndicales et milieux associatifs en Belgique. Dans la première partie, il passe en revue la littérature scientifique internationale consacrée au syndi­ca­lisme et aux “nouveaux mouvements sociaux” afin de dégager des hypothèses de travail spécifiquement applicables à l’étude, peu développée, des relations entre ces deux types d’acteurs. Dans la partie em­pirique, il aborde, dans le contexte belge, les positions adoptées par les syndicats et les mouvements as­sociatifs face à la réforme du “minimum de moyens d’existence” (minimex et les mo­bilisations engen­drées par cette réforme. Il souligne l’existence de différences importantes entre les atti­tudes de certaines associations (la Ligue des Droits de l’Homme, des organisations de sans-emploi et de pré­caires, etc. et la position officielle des grands syndicats. L’étude met également en lumière les diffé­rences de réaction perceptibles entre les associations elles-mêmes et au sein des deux principales orga­nisations syndicales nationales. L’auteur cherche enfin à expliquer les différentes logiques à l’œu­vre et confronte hypothèses de travail et étude empirique quant aux relations qu’entretiennent syndicats et associations.In the light of work on Trade Unions and New Social Movements, hypotheses as to their relationships in Belgium are here elaborated. Their respective positions and campaigns regarding basic income are empirically examined. Significant differences between the Union stance and that of given associations such those concerned with human rights or the unemployed, are highlighted. Divergences also appear amongst the associations themselves as well as between the two main Unions. The contribution concludes with an analysis of the various logics at stake and the empirical relevance of the afore mentioned hypotheses.

  18. Association of serum uric acid with different levels of glucose and related factors

    Institute of Scientific and Technical Information of China (English)

    YUAN Hui-juan; YANG Xu-guang; SHI Xiao-yang; TIAN Rui; ZHAO Zhi-gang

    2011-01-01

    Background Previous studies have demonstrated that serum uric acid (UA) is an independent predictor of incident type 2 diabetes mellitus (T2DM) in general populations. This study aimed to investigate specific characteristics of UA and its relationship between UA and blood glucose and other risk factors in the Chinese population.Methods A total of 946 subjects were included in this study. UA, glucose, insulin, fractional excretion of UA (FEua),creatinine clearance rate (Ccr), hemoglobin A1c (HbA1c), fructosamine (FA), blood pressure and lipids were studied and also reexamined after the patients underwent two weeks of combined therapeutics.Results UA levels were the highest in subjects with impaired glucose regulation (IGR), followed by subjects with normoglycemia (NGT) and finally by subjects with T2DM. The level of the 2-hour postprandial insulin and the area under the curve for insulin (AUCins) showed a similar tendency. The UA levels initially increased with increasing fasting blood glucose (FBG) and postprandial blood glucose (PPBG) levels, up to 7 mmol/L and 10 mmol/L, respectively, and thereafter decreased at higher FBG and PPBG levels. Compared with subjects in the lower serum UA quartile, subjects in the upper quartile of serum UA levels had higher weights, triglyceride levels, and creatinine levels as well as lower Ccr and FEua levels. Compared with women's group, UA levels were higher, and FEua levels were lower in men's group. Sex,body mass index (BMI), mean arterial blood pressure (MAP), serum triglycerides (TG), FA and Ccr were independent correlation factors of UA. UA decreased and FEua increased after the patients underwent a combined treatment.Conclusions UA increased initially and then decreased as glucose levels increased from NGT to IGR and T2DM.Compared with NGT and T2DM, IGR subjects had higher SUA levels, which related to its high levels of insulin. Under T2DM, male gender, BMI, MAP, Ccr, TG and FA are independent correlation factors of UA

  19. IgG4-related Lung Disease Associated with Autoimmune Hemolytic Anemia: A Case Report and a Literature Review.

    Science.gov (United States)

    Noguchi, Shingo; Yatera, Kazuhiro; Jinbo, Mitsutaka; Yamada, Sohsuke; Shimabukuro, Ikuko; Yamasaki, Kei; Kido, Takashi; Ishimoto, Hiroshi; Yoshii, Chiharu; Mukae, Hiroshi

    2016-01-01

    We herein report a case of IgG4-related lung disease (IgG4-RLD) associated with autoimmune hemolytic anemia (AIHA). A 73-year-old Japanese female visited our hospital for an examination following an abnormal chest X-ray in 1999. She was diagnosed with bronchiolitis and AIHA, and treatment with prednisolone was started. After seven years, she visited our department due to a cough. Chest computed tomography (CT) demonstrated focal consolidation with ground-glass attenuations and thickened bronchial walls in the bilateral lungs. She was clinically diagnosed and treated for bronchial asthma. CT findings had shown no changes, and a lung biopsy was performed using video-assisted thoracic surgery at eleven years from the first diagnosis of AIHA. The pathological findings demonstrated the presence of peribronchovascular lymphoplasmacytic infiltrates with stromal fibrotic changes, admixed with many IgG4-positive plasma cells. Furthermore, the patient's serum IgG4 level was high, and her CT findings did not show any obvious abnormal findings in the any organs other than the lungs. She was diagnosed with IgG4-RLD based on the findings. We believe that this case report of IgG4-RLD associated with AIHA is clinically helpful for a better understanding of these diseases, although there are five reported cases of IgG4-related disease associated with AIHA. PMID:27580552

  20. Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population.

    Science.gov (United States)

    Lu, Yanjun; Li, Qian; Peng, Jing; Zhu, Yaowu; Wang, Feng; Wang, Chunyu; Wang, Xiong

    2016-03-01

    The autophagy-related immunity-related GTPase family M protein, IRGM, plays an important role in the defense against tuberculosis (TB) infection. IRGM polymorphisms are associated with TB infection susceptibility, and recent studies demonstrate host genetic differences between active and latent TB. Here, we investigated the association between IRGM polymorphisms and TB infection type in a Chinese population. We recruited 268 and 321 patients with confirmed or latent TB, respectively, and 475 TB-free healthy controls. Three single nucleotide polymorphisms, rs10065172, rs10051924, and rs13361189 within IRGM were genotyped using TaqMan-based assays. Interferon-gamma release levels were tested by T-SPOT. rs10065172 (P = 0.024, OR 0.67 (95% CI 0.48-0.95)), rs10051924 (P = 0.01, OR 0.64 (95% CI 0.46-0.90)), and rs13361189 (P = 0.055, OR 0.72 (95% CI 0.51-1.01)) were associated with a protective role against latent TB progression. Haplotype analysis showed that TCC was protective for latent TB (P = 0.022, OR 0.74 (95% CI 0.57-0.96)) whereas TTC conferred a higher risk of active TB. Additionally, patients with the rs10065172 TT genotype had a higher response to TB specific antigens. Thus, IRGM polymorphism differences between latent and active TB suggests that genetic differences in autophagy might partly affect host TB infection status. PMID:26980495

  1. Identification of specific activities associated with fall-related injuries, active component, U.S. Army, 2011.

    Science.gov (United States)

    Hauschild, Veronique D; Schuh, Anna; Taylor, Bonnie J; Canham-Chervak, Michelle; Jones, Bruce H

    2016-06-01

    Although falls continue to be a leading mechanism of serious injuries among military populations, interventions must target activities or hazards that can be controlled or managed. This project aimed to identify activities most frequently associated with Army soldier fall-related injuries to prioritize prevention strategies for this substantial health burden. Narrative data from Army safety, medical evacuation, and casualty reporting systems were reviewed to select incidents meeting inclusion criteria and assign established codes. Nondeployed (n=988) and deployed (n=254) injury rates were not statistically different (2.20 per 1,000 non-deployed person-years [p-yrs], 2.21 per 1,000 deployed p-yrs, respectively). More than 75% of injuries were temporarily disabling fractures, sprains, and strains, primarily to lower extremities. The most frequent activities associated with non-deployed fall injuries were sports (e.g., snowboarding and basketball; 22%), parachuting (20%), walking/marching (19%), and climbing (15%). Ice and snow were the leading hazard (43%). The most common associated activities among deployed soldiers were occupational tasks (53%), walking/patrolling (24%), climbing (23%), and sports (17%). Specific interventions that target the activities and hazards identified in this investigation are suggested as priorities to reduce Army fall-related injuries. PMID:27362343

  2. Linguistic characteristics in a non-trauma-related narrative task are associated with PTSD diagnosis and symptom severity.

    Science.gov (United States)

    Papini, Santiago; Yoon, Patricia; Rubin, Mikael; Lopez-Castro, Teresa; Hien, Denise A

    2015-05-01

    Linguistic characteristics of trauma narratives have been linked to the development and severity of posttraumatic stress disorder (PTSD). However, it remains unclear if linguistic markers of PTSD exist beyond the scope of trauma narratives. This study used ambiguous visual prompts to elicit spontaneous narratives from trauma-exposed individuals with (n = 23) and without PTSD (n = 30). Individuals with PTSD used more singular pronouns and death-related words, and fewer plural pronouns. Within the PTSD group, increased severity of reexperiencing symptoms was associated with greater use of singular pronouns and lower use of cognitive words; increased severity of avoidance symptoms was associated with lower use of death words; and increased severity of hyperarousal symptoms was associated with less frequent use of anxiety words. Together, these linguistic variables accounted for 53% of the variance in total PTSD symptom severity. These findings are consistent with previous research suggesting that language use is a strong predictor of PTSD psychopathology, and extend the evidence to include the linguistic characteristics of non-trauma-related narratives. PMID:25961121

  3. Association of Serum Ferritin and Kidney Function with Age-Related Macular Degeneration in the General Population

    Science.gov (United States)

    Oh, Il Hwan; Choi, Eun Young; Park, Joon-Sung; Lee, Chang Hwa

    2016-01-01

    Ferritin is considered to be a marker of the body’s iron stores and has a potential relationship with the systemic manifestations of inflammatory reactions. Data on the association between increased levels of serum ferritin and ocular problems are limited, particularly in relation to age-related macular degeneration (AMD). Serum ferritin levels, as a possible clinical parameter for predicting AMD, were analyzed in anthropometric, biochemical, and ophthalmologic data from a nation-wide, population-based, case-control study (KNHNES IV and V). All native Koreans aged ≥ 20 years and who had no medical illness were eligible to participate. Among them, 2.9% had AMD, and its prevalence was found to increase in the higher ferritin quintile groups (Ptrend AMD. Comparison of early AMD with a control group showed that serum ferritin levels were closely associated with AMD (OR = 1.004, 95% CI = 1.002–1.006), and further adjustment for age, gender, serum iron, and kidney function did not reduce this association (OR = 1.003, 95% CI = 1.001–1.006). Furthermore, the relationship between ferritin quintile and early AMD was dose-dependent. Thus, an increased level of serum ferritin in a healthy person may be a useful indicator of neurodegenerative change in the macula. A large population-based prospective clinical study is needed to confirm these findings. PMID:27096155

  4. Factors associated with health related quality of life after a hip or knee total replacement, according to a gender approach

    Directory of Open Access Journals (Sweden)

    Sergio R. López Alonso

    2010-07-01

    Full Text Available Objective: To identify the factors associated with Health Related Quality of Life (HRQL, and Symptoms and Physical Functional Disability (S&PFD after a Hip or Knee Total Replacement, according to a gender approach. A longitudinal cohort study design is performed at “La Merced” (Osuna. Sevilla and “Torrecárdenas” (Almería Hospitals, via telephone interview since October 2004 to November 2006. The study included all people who underwent a hip or knee total replacement. The dependent variables were HRQL and S&PFD, both measured via short versions of the COOP/WONCA and WOMAC questionnaires.Results: 311 people were included, who were mostly women (82,63% and 70 years old (average. The hip and knee replacement obtained an statistically significant improvement on HRQL (20,5% and S&PFD (28,2%, with no gender difference. Five variables were associated to HRQL for Women: HRQL previous to surgery, hospital, local infection as a complication, autonomy for daily living, and marital status. All of them were associated to men, except the last two ones. About S&PFD, six variables were associated for women: HRQL and S&PFD previous to surgery, hospital, local infection as a complication, body mass index and marital status. All of them were associated to men, except the last two ones.Factors associated to improve on HRQL and S&PFD in male population are few, though they find a great explanation of the improvement. Different situation arise on female population because more factors obtained a substantially inferior explanation.

  5. Associations between Heart Rate Variability Parameters and Housing- and Individual-Related Variables in Dairy Cows Using Canonical Correspondence Analysis

    Science.gov (United States)

    Bakony, Mikolt; Hufnágel, Levente; Tőzsér, János; Jurkovich, Viktor

    2015-01-01

    We investigated the associations between heart rate variability (HRV) parameters and some housing- and individual-related variables using the canonical correspondence analysis (CCOA) method in lactating Holstein-Friesian dairy cows. We collected a total of 5200 5-min interbeat interval (IBI) samples from 260 animals on five commercial dairy farms [smaller-scale farms with 70 (Farm 1, n = 50) and 80 cows per farm (Farm 2, n = 40), and larger-scale farms with 850 (Farm 3, n = 66), 1900 (Farm 4, n = 60) and 1200 (Farm 5, n = 45) cows. Dependent variables included HRV parameters, which reflect the activity of the autonomic nervous system: heart rate (HR), the root mean square of successive differences (RMSSD) in IBIs, the standard deviation 1 (SD1), the high frequency (HF) component of HRV and the ratio between the low frequency (LF) and the HF parameter (LF/HF). Explanatory variables were group size, space allowance, milking frequency, parity, daily milk yield, body condition score, locomotion score, farm, season and physical activity (lying, lying and rumination, standing, standing and rumination and feeding). Physical activity involved in standing, feeding and in rumination was associated with HRV parameters, indicating a decreasing sympathetic and an increasing vagal tone in the following order: feeding, standing, standing and rumination, lying and rumination, lying. Objects representing summer positioned close to HR and LF and far from SD1, RMSSD and HF indicate a higher sympathetic and a lower vagal activity. Objects representing autumn, spring and winter associated with increasing vagal activity, in this order. Time-domain measures of HRV were associated with most of the housing- and individual-related explanatory variables. Higher HR and lower RMSSD and SD1 were associated with higher group size, milking frequency, parity and milk yield, and low space allowance. Higher parity and milk yield were associated with higher sympathetic activity as well (higher LF

  6. Intimate Partner Violence Is Associated with Stress-Related Sleep Disturbance and Poor Sleep Quality during Early Pregnancy.

    Directory of Open Access Journals (Sweden)

    Sixto E Sanchez

    Full Text Available To examine the associations of Intimate partner violence (IPV with stress-related sleep disturbance (measured using the Ford Insomnia Response to Stress Test [FIRST] and poor sleep quality (measured using the Pittsburgh Sleep Quality Index [PSQI] during early pregnancy.This cross-sectional study included 634 pregnant Peruvian women. In-person interviews were conducted in early pregnancy to collect information regarding IPV history, and sleep traits. Adjusted odds ratios (aOR and 95% confidence intervals (95%CIs were calculated using logistic regression procedures.Lifetime IPV was associated with a 1.54-fold increased odds of stress-related sleep disturbance (95% CI: 1.08-2.17 and a 1.93-fold increased odds of poor sleep quality (95% CI: 1.33-2.81. Compared with women experiencing no IPV during lifetime, the aOR (95% CI for stress-related sleep disturbance associated with each type of IPV were: physical abuse only 1.24 (95% CI: 0.84-1.83, sexual abuse only 3.44 (95%CI: 1.07-11.05, and physical and sexual abuse 2.51 (95% CI: 1.27-4.96. The corresponding aORs (95% CI for poor sleep quality were: 1.72 (95% CI: 1.13-2.61, 2.82 (95% CI: 0.99-8.03, and 2.50 (95% CI: 1.30-4.81, respectively. Women reporting any IPV in the year prior to pregnancy had increased odds of stress-related sleep disturbance (aOR = 2.07; 95% CI: 1.17-3.67 and poor sleep quality (aOR = 2.27; 95% CI: 1.30-3.97 during pregnancy.Lifetime and prevalent IPV exposures are associated with stress-related sleep disturbance and poor sleep quality during pregnancy. Our findings suggest that sleep disturbances may be important mechanisms that underlie the lasting adverse effects of IPV on maternal and perinatal health.

  7. Association of the Common Genetic Variant Upstream of INSIG2 Gene with Obesity Related Phenotypes in Chinese Children and Adolescents

    Institute of Scientific and Technical Information of China (English)

    HAI-JUN WANG; HENG ZHANG; SHI-WEI ZHANG; YONG-PING PAN; JUN MA

    2008-01-01

    To study the association between the rs7566605 variant of INSIG2 and obesity-related phenotypes in Chinese children and adolescents.Methods The study sample consisted of two independent cohorts of Chinese children and adolescents.Anthropometric indices,lipids,blood pressure,fasting glucose,insulin and percentage of fat mass were determined.PCR with restriction fragment length polymorphism analysis was performed for genotyping the rs7566605 variant.Results In each of the two independent cohorts,no significant association was observed between rs7566605 and obesity under additive,dominant or recessive model.We also did not detect any difference in the genotype frequency between all the obese children and controls.Furthermore,we did not find evidence of an association between body composition indices and metabolic phenotypes in all children.However,the triglyceride level of CC homozygotes was significantly higher than that of GG+GC genotypes in obese children (P=0.022).Additionally,we observed a non-significant trend of severe obesity in a post-hoc test.Conclusion INSIG2 rs7566605 variant is not associated Chinese childhood obesity in two independent cohorts.Further study is needed to verify the effect of rs7566605 on triglyceride in obese children.

  8. Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

    International Nuclear Information System (INIS)

    We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy. Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis. There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716). Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study. Raw data are available at ArrayExpress under accession number E-MEXP-2460

  9. Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

    Directory of Open Access Journals (Sweden)

    Bøhn Siv K

    2012-09-01

    Full Text Available Abstract Background We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy. Methods Out of 87 patients (histologically verified, 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis. Results There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791, and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716. Conclusions Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study. Trial registration Raw data are available at ArrayExpress under accession number E-MEXP-2460.

  10. Post-partum sequential occurrence of two diverse transfusion reactions (transfusion associated circulatory overload and transfusion related acute lung injury

    Directory of Open Access Journals (Sweden)

    Rudrashish Haldar

    2013-01-01

    Full Text Available Transfusion associated circulatory overload (TACO and transfusion related acute lung injury (TRALI are two dissimilar pathological conditions associated with transfusion of blood products where the time course of the events and clinical presentation overlap leading to uncertainty in establishing the diagnosis and initiating the treatment, which otherwise differs. We encountered a case where a patient of post-partum hemorrhage developed TACO in the immediate post-operative period due to aggressive resuscitative attempts with blood products. The patient′s condition was appropriately diagnosed and was managed according to the clinical scenario, and the condition abated. Subsequently, on the third post-operative day the patient again required blood product transfusions following which the patient developed TRALI, the diagnosis of which was also established and adequate treatment strategy was undertaken.

  11. An Assessment of Health Related Quality of Life in a Male Prison Population in Greece Associations with Health Related Characteristics and Characteristics of Detention

    Directory of Open Access Journals (Sweden)

    Constantinos Togas

    2014-01-01

    Full Text Available Background. Prisoners constitute a group with increased health and social care needs. Although implementing policies that aim at improving outcomes within this population should be a priority area, studies that attempt to assess health outcomes and health related quality of life (HRQoL in this population are limited. Aim. To assess HRQoL in a prison population in Greece and to explore the relationship between HRQoL and a set of individual sociodemographic and health related characteristics and characteristics of detention. Methods. A cross-sectional study involving 100 male prisoners was conducted in the prison of Corinth in Greece. HRQoL was assessed through the use of the SF-36 and the EQ-5D. Results. The mean physical and mental summary scores of the SF-36 were 55.33 and 46.82, respectively. The EQ-VAS mean score was 76.41%, while the EQ-5D index was 0.72. Multivariate analysis identified a statistical relationship between HRQoL and the conditions of detention, controlling for the effect of sociodemographic characteristics, morbidity, and mental problems. The use of narcotics in particular is significantly associated with lower HRQoL. Conclusions. Implementation of policies that aim at preventing the use of narcotics within the prison environment is expected to contribute to improved HRQoL in this population.

  12. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.

    Directory of Open Access Journals (Sweden)

    Jian Zhao

    2011-05-01

    Full Text Available Systemic lupus erythematosus (SLE, a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH and five CFH-related proteins (CFHR1-CFHR5 within the chromosome 1q32 locus linked to SLE, have been associated with multiple human diseases and may contribute to dysregulated complement activation predisposing to SLE. We assessed 60 SNPs covering the CFH-CFHRs region for association with SLE in 15,864 case-control subjects derived from four ethnic groups. Significant allelic associations with SLE were detected in European Americans (EA and African Americans (AA, which could be attributed to an intronic CFH SNP (rs6677604, in intron 11, P(meta = 6.6×10(-8, OR = 1.18 and an intergenic SNP between CFHR1 and CFHR4 (rs16840639, P(meta = 2.9×10(-7, OR = 1.17 rather than to previously identified disease-associated CFH exonic SNPs, including I62V, Y402H, A474A, and D936E. In addition, allelic association of rs6677604 with SLE was subsequently confirmed in Asians (AS. Haplotype analysis revealed that the underlying causal variant, tagged by rs6677604 and rs16840639, was localized to a ~146 kb block extending from intron 9 of CFH to downstream of CFHR1. Within this block, the deletion of CFHR3 and CFHR1 (CFHR3-1Δ, a likely causal variant measured using multiplex ligation-dependent probe amplification, was tagged by rs6677604 in EA and AS and rs16840639 in AA, respectively. Deduced from genotypic associations of tag SNPs in EA, AA, and AS, homozygous deletion of CFHR3-1Δ (P(meta = 3.2×10(-7, OR = 1.47 conferred a higher risk of SLE than heterozygous deletion (P(meta = 3.5×10(-4, OR = 1.14. These results suggested that the CFHR3-1Δ deletion within the SLE-associated block, but not the previously described exonic SNPs of CFH, might contribute to the development of SLE in EA, AA, and AS, providing new insights into the role of

  13. New aspects of osteoporosis: Bone mineral content (BMC) measurement in osteoporosis associated with drugs, arthritis, and related conditions

    International Nuclear Information System (INIS)

    Sensitive, non-invasive measurements of bone mineral content (BMC) provide the means to identify and characterize, prior to the development of symptoms, osteoporosis associated with drugs, rheumatoid arthritis, inflammatory bowel disease, diabetes mellitus, anorexia nervosa and immobilization. Moreover, BMC can be used to effectively screen populations at risk for the development of osteoporosis and longitudinal studies in individual patients can be used to guide effective anti-osteopenia therapy. This review will briefly detail recent BMC measurements in osteoporosis due to drugs, arthritis and related conditions. (orig.)

  14. New aspects of osteoporosis: Bone mineral content (BMC) measurement in osteoporosis associated with drugs, arthritis, and related conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gross, M.D.; Shapiro, B.

    1987-02-01

    Sensitive, non-invasive measurements of bone mineral content (BMC) provide the means to identify and characterize, prior to the development of symptoms, osteoporosis associated with drugs, rheumatoid arthritis, inflammatory bowel disease, diabetes mellitus, anorexia nervosa and immobilization. Moreover, BMC can be used to effectively screen populations at risk for the development of osteoporosis and longitudinal studies in individual patients can be used to guide effective anti-osteopenia therapy. This review will briefly detail recent BMC measurements in osteoporosis due to drugs, arthritis and related conditions.

  15. Sleep spindle-related reactivation of category-specific cortical regions after learning face-scene associations

    DEFF Research Database (Denmark)

    Bergmann, Til O; Mölle, Matthias; Diedrichs, Jens;

    2012-01-01

    Newly acquired declarative memory traces are believed to be reactivated during NonREM sleep to promote their hippocampo-neocortical transfer for long-term storage. Yet it remains a major challenge to unravel the underlying neuronal mechanisms. Using simultaneous electroencephalography (EEG) and...... functional magnetic resonance imaging (fMRI) recordings in humans, we show that sleep spindles play a key role in the reactivation of memory-related neocortical representations. On separate days, participants either learned face-scene associations or performed a visuomotor control task. Spindle......-neocortical memories during sleep....

  16. Association and gene-gene interactions study of reelin signaling pathway related genes with autism in the Han Chinese population.

    Science.gov (United States)

    Shen, Yidong; Xun, Guanglei; Guo, Hui; He, Yiqun; Ou, Jianjun; Dong, Huixi; Xia, Kun; Zhao, Jingping

    2016-04-01

    Autism is a neurodevelopmental disorder with unclear etiology. Reelin had been proposed to participate in the etiology of autism due to its important role in brain development. The goal of this study was to explore the association and gene-gene interactions of reelin signaling pathway related genes (RELN, VLDLR, LRP8, DAB1, FYN, and CDK5) with autism in Han Chinese population. Genotyping data of the six genes were obtained from a recent genome-wide association study performed in 430 autistic children who fulfilled the DSM-IV-TR criteria for autistic disorder, and 1,074 healthy controls. Single marker case-control association analysis and haplotype case-control association analysis were conducted after the data was screened. Multifactor dimensionality reduction (MDR) was applied to further test gene-gene interactions. Neither the single marker nor the haplotype association tests found any significant difference between the autistic group and the control group after permutation test of 1,000 rounds. The 4-locus MDR model (comprising rs6143734, rs1858782, rs634500, and rs1924267 which belong to RELN and DAB1) was determined to be the model with the highest cross-validation consistency (CVC) and testing balanced accuracy. The results indicate that an interaction between RELN and DAB1 may increase the risk of autism in the Han Chinese population. Furthermore, it can also be inferred that the involvement of RELN in the etiology of autism would occur through interaction with DAB1. Autism Res 2016, 9: 436-442. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. PMID:26285919

  17. ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila.

    Science.gov (United States)

    van der Voet, M; Harich, B; Franke, B; Schenck, A

    2016-04-01

    Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder with hyperactivity as one of the hallmarks. Aberrant dopamine signaling is thought to be a major theme in ADHD, but how this relates to the vast majority of ADHD candidate genes is illusive. Here we report a Drosophila dopamine-related locomotor endophenotype that is shared by pan-neuronal knockdown of orthologs of the ADHD-associated genes Dopamine transporter (DAT1) and Latrophilin (LPHN3), and of a gene causing a monogenic disorder with frequent ADHD comorbidity: Neurofibromin (NF1). The locomotor signature was not found in control models and could be ameliorated by methylphenidate, validating its relevance to symptoms of the disorder. The Drosophila ADHD endophenotype can be further exploited in high throughput to characterize the growing number of candidate genes. It represents an equally useful outcome measure for testing chemical compounds to define novel treatment options. PMID:25962619

  18. Association between Lactobacillus species and bacterial vaginosis-related bacteria, and bacterial vaginosis scores in pregnant Japanese women

    Directory of Open Access Journals (Sweden)

    Yamada Hideto

    2007-11-01

    Full Text Available Abstract Background Bacterial vaginosis (BV, the etiology of which is still uncertain, increases the risk of preterm birth. Recent PCR-based studies suggested that BV is associated with complex vaginal bacterial communities, including many newly recognized bacterial species in non-pregnant women. Methods To examine whether these bacteria are also involved in BV in pregnant Japanese women, vaginal fluid samples were taken from 132 women, classified as normal (n = 98, intermediate (n = 21, or BV (n = 13 using the Nugent gram stain criteria, and studied. DNA extracted from these samples was analyzed for bacterial sequences of any Lactobacillus, four Lactobacillus species, and four BV-related bacteria by PCR with primers for 16S ribosomal DNA including a universal Lactobacillus primer, Lactobacillus species-specific primers for L. crispatus, L. jensenii, L. gasseri, and L. iners, and BV-related bacterium-specific primers for BVAB2, Megasphaera, Leptotrichia, and Eggerthella-like bacterium. Results The prevalences of L. crispatus, L. jensenii, and L. gasseri were significantly higher, while those of BVAB2, Megasphaera, Leptotrichia, and Eggerthella-like bacterium were significantly lower in the normal group than in the BV group. Unlike other Lactobacillus species, the prevalence of L. iners did not differ between the three groups and women with L. iners were significantly more likely to have BVAB2, Megasphaera, Leptotrichia, and Eggerthella-like bacterium. Linear regression analysis revealed associations of BVAB2 and Megasphaera with Nugent score, and multivariate regression analyses suggested a close relationship between Eggerthella-like bacterium and BV. Conclusion The BV-related bacteria, including BVAB2, Megasphaera, Leptotrichia, and Eggerthella-like bacterium, are common in the vagina of pregnant Japanese women with BV. The presence of L. iners may be correlated with vaginal colonization by these BV-related bacteria.

  19. Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Hidetaka Hamasaki

    2015-05-01

    Full Text Available Background. Age-related loss of muscle mass (sarcopenia increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of two sarcopenic indices, the ratio of lower extremity muscle mass to body weight (L/W ratio and the ratio of lower extremity muscle mass to upper extremity muscle mass (L/U ratio, with metabolic parameters related to obesity in patients with type 2 diabetes and obesity. Methods. Of 148 inpatients with type 2 diabetes treated between October 2013 and April 2014, we recruited 26 with obesity but no physical disability. Daily physical activity was measured by a triaxial accelerometer during a period of hospitalization, and which was also evaluated by our previously reported non-exercise activity thermogenesis questionnaire. We measured body composition by bioelectrical impedance and investigated the correlations of L/W and L/U ratios with body weight, body mass index (BMI, waist circumference (WC, waist-to-hip ratio (WHR, visceral fat area, subcutaneous fat area, serum lipid profile, and daily physical activity. Results. The L/W ratio was significantly and negatively correlated with BMI, WC, WHR, body fat mass, body fat percentage, subcutaneous fat area, and serum free fatty acid concentration, was positively correlated with daily physical activity: the locomotive non-exercise activity thermogenesis score, but was not correlated with visceral fat area. The L/U ratio was significantly and positively correlated with serum high-density lipoprotein cholesterol. Conclusions. High L/W and L/U ratios, indicative of relatively preserved lower extremity muscle mass, were predictive of improved metabolic parameters related to obesity. Preserved muscle fitness in obesity, especially of the lower extremities, may prevent sarcopenic obesity and lower associated risks

  20. Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes.

    Science.gov (United States)

    Hamasaki, Hidetaka; Kawashima, Yu; Adachi, Hiroki; Moriyama, Sumie; Katsuyama, Hisayuki; Sako, Akahito; Yanai, Hidekatsu

    2015-01-01

    Background. Age-related loss of muscle mass (sarcopenia) increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of two sarcopenic indices, the ratio of lower extremity muscle mass to body weight (L/W ratio) and the ratio of lower extremity muscle mass to upper extremity muscle mass (L/U ratio), with metabolic parameters related to obesity in patients with type 2 diabetes and obesity. Methods. Of 148 inpatients with type 2 diabetes treated between October 2013 and April 2014, we recruited 26 with obesity but no physical disability. Daily physical activity was measured by a triaxial accelerometer during a period of hospitalization, and which was also evaluated by our previously reported non-exercise activity thermogenesis questionnaire. We measured body composition by bioelectrical impedance and investigated the correlations of L/W and L/U ratios with body weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral fat area, subcutaneous fat area, serum lipid profile, and daily physical activity. Results. The L/W ratio was significantly and negatively correlated with BMI, WC, WHR, body fat mass, body fat percentage, subcutaneous fat area, and serum free fatty acid concentration, was positively correlated with daily physical activity: the locomotive non-exercise activity thermogenesis score, but was not correlated with visceral fat area. The L/U ratio was significantly and positively correlated with serum high-density lipoprotein cholesterol. Conclusions. High L/W and L/U ratios, indicative of relatively preserved lower extremity muscle mass, were predictive of improved metabolic parameters related to obesity. Preserved muscle fitness in obesity, especially of the lower extremities, may prevent sarcopenic obesity and lower associated risks for metabolic