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Sample records for assesstment homa fundamento

  1. homa gheybi

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. HOMA GHEYBI. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 29. A focus on the features of polyaniline nanofibres prepared via developing the single crystals of their block copolymers with poly(ethylene glycol) · MARYAM NAZARI ...

  2. Fundamentos del saber administrativo

    OpenAIRE

    Paola Podestá Correa; Juan Carlos Jurado Jurado

    2005-01-01

    El presente texto tiene por objetivo delimitar, de manera general, algunos de los conceptos más importantes del saber administrativo; en primera instancia, práctica administrativa y saber administrativo. Estos conceptos están ligados con los que en el texto se denominan fundamentos de la administración, estableciendo consensos sobre algunas expresiones comunes en el lenguaje administrativo, y contribuyendo a la comprensión de estos temas para los estudiantes de los primeros niv...

  3. The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS).

    Science.gov (United States)

    Vilela, Brunna Sullara; Vasques, Ana Carolina Junqueira; Cassani, Roberta Soares Lara; Forti, Adriana Costa E; Pareja, José Carlos; Tambascia, Marcos Antonio; Geloneze, Bruno

    2016-01-01

    The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD. The Brazilian Metabolic Syndrome Study (BRAMS) is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18-65 years old, BMI: 18.5-49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample) and by the hyperglycemic clamp (n = 49). Metabolic syndrome was defined using the IDF criteria. For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64) compared with the HOMA1-IR (r = -0.56); p HOMA1-IR, the HOMA-AD showed higher values of the AUC for the identification of IR based on the clamp test (AUC: 0.844 vs. AUC: 0.804) and on the metabolic syndrome (AUC: 0.703 vs. AUC: 0.689), respectively; p HOMA-AD in comparison with the HOMA1-IR in the diagnosis of IR and metabolic syndrome (p > 0.05). The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95. The HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities.

  4. Fundamentos Conceptuales del Resultado Global

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    Francisco Sousa Fernández

    2009-12-01

    Full Text Available Con el propósito de reportar una mayor utilidad a los inversores, desde la década de los noventa del siglo XX los organismos emisores de normas contables más influyentes en el panorama internacional, entre los que cabe destacar el IASB y el FASB, han incorporado a sus cuerpos normativos el resultado global, asumido también en la Circular 4/2004 del Banco de España y en el Plan General de Contabilidad 2007.Ante esta concepción novedosa del resultado empresarial para nuestro entorno, este trabajo plantea como objetivo esencial revisar, acotar y sintetizar sus fundamentos teóricos, dispersos a lo largo del siglo XX, fundamentalmente en la literatura contable anglosajona.Una vez delimitado su soporte conceptual, además de destacar la existencia de un gap significativo entre el mismo y la realidad de su regulación actual, queremos analizar la incidencia de su adopción en la práctica, para lo que revisamos las contribuciones empíricas de los últimos años.For the convenience of investors, since the 1990s the most influential accounting standard-setters on the international scene, including the IASB and the FASB, have incorporated the concept of comprehensive income, also adopted in Circular 4/2004 of the Bank of Spain and in the 2007 General Accounting Plan.In view of this new conception of corporate income for our environment, this study aims to review, delimit and synthesize its theoretical foundations, found throughout the 20th Century, predominantly in the Anglo-Saxon accounting literature.Once its conceptual foundations are delimited, besides emphasizing the existence of a significant gap between such conceptual foundations and the reality of present regulations, we will analyze the effect of the adoption of this new conception in practice. To do so, the empirical contributions over the last few years will be taken into consideration.

  5. The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS)

    Science.gov (United States)

    Cassani, Roberta Soares Lara; Forti, Adriana Costa e; Pareja, José Carlos; Tambascia, Marcos Antonio; Geloneze, Bruno

    2016-01-01

    Background The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. Objectives To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD. Subjects/Methods The Brazilian Metabolic Syndrome Study (BRAMS) is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18–65 years old, BMI: 18.5–49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample) and by the hyperglycemic clamp (n = 49). Metabolic syndrome was defined using the IDF criteria. Results For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64) compared with the HOMA1-IR (r = -0.56); p 0.05). The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95. Conclusions The HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities. PMID:27490249

  6. The HOMA-Adiponectin (HOMA-AD Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS.

    Directory of Open Access Journals (Sweden)

    Brunna Sullara Vilela

    Full Text Available The major adverse consequences of obesity are associated with the development of insulin resistance (IR and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index.To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD.The Brazilian Metabolic Syndrome Study (BRAMS is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18-65 years old, BMI: 18.5-49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample and by the hyperglycemic clamp (n = 49. Metabolic syndrome was defined using the IDF criteria.For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64 compared with the HOMA1-IR (r = -0.56; p 0.05. The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95.The HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities.

  7. Radioactivity And Dose Assessment Of Rock And Soil Samples From Homa Mountain, Homa Bay County, Kenya

    International Nuclear Information System (INIS)

    Otwoma, D.; Patel, J.P.; Bartilol, S.; Mustapha, A.O.

    2013-01-01

    The in situ measured average outdoor absorbed dose rate in air was found to vary from 108.4 to 1596.4 n Gy h -1 at Homa Mountain area in southwestern Kenya. Rock and soil samples collected gave average values of the radioactivity concentrations of 40 K, 226 Ra and 232 Th of 915.6, 195.3 and 409.5 Bq kg -1 , respectively. The range of the annual effective dose for a person living in Homa Mountain area calculated varied from 28.6 to 1681.2, with a mean of 470.4 μSv. These results imply Homa Mountain have elevated levels of natural radioactivity thus the region is a high background radiation area

  8. Fundamentos de neurocomputación

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    Germán J. Hernández

    1993-07-01

    Full Text Available En este documento se realiza una introducción histórica al desarrollo de la neurocomputación, se estudian los fundamentos teóricos que describen el funcionamiento de los dispositivos computacionales neuronales, llamados también Redes Neuronales Artificiales (RNA's y se menciona una gama de aplicaciones que tienen tales dispositivos en la solución de problemas en Ciencias e Ingeniería.

  9. Leitura de Heidegger - sobre o fundamento

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    Miguel Antonio do Nascimento

    2010-10-01

    Full Text Available A questáo do fundamento traz a tona críticas a metafisica. No pensamento de Heidegger, esta questáo mostra que o ontológico náo se reduz as deterrninações metafisicas. Este fato como tal é que precisaria suscitar interesse e ser aprofundado. Criticas generalizadas e correntes a metafisica náo tomam isto como seu objetivo. .

  10. [Homeostasis model assessment (HOMA) values in Chilean elderly subjects].

    Science.gov (United States)

    Garmendia, María Luisa; Lera, Lydia; Sánchez, Hugo; Uauy, Ricardo; Albala, Cecilia

    2009-11-01

    The homeostasis assessment model for insulin resistance (HOMA-IR) estimates insulin resistance using basal insulin and glucose values and has a good concordance with values obtained with the euglycemic clamp. However it has a high variability that depends on environmental, genetic and physiologic factors. Therefore it is imperative to establish normal HOMA values in different populations. To report HOMA-IR values in Chilean elderly subjects and to determine the best cutoff point to diagnose insulin resistance. Cross sectional study of 1003 subjects older than 60 years of whom 803 (71% women) did not have diabetes. In 154 subjects, an oral glucose tolerance test was also performed. Insulin resistance (IR) was defined as the HOMA value corresponding to percentile 75 of subjects without over or underweight. The behavior of HOMA-IR in metabolic syndrome was studied and receiver operating curves (ROC) were calculated, using glucose intolerance defined as a blood glucose over 140 mg/dl and hyperinsulinemia, defined as a serum insulin over 60 microU/ml, two hours after the glucose load. Median HOMA-IR values were 1.7. Percentile 75 in subjects without obesity or underweight was 2.57. The area under the ROC curve, when comparing HOMA-IR with glucose intolerance and hyperinsulinemia, was 0.8 (95% confidence values 0.72-0.87), with HOMA-IR values ranging from 2.04 to 2.33. HOMA-IR is a useful method to determine insulin resistance in epidemiological studies. The HOMA-IR cutoff point for insulin resistance defined in thi spopulation was 2.6.

  11. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS).

    Science.gov (United States)

    Geloneze, Bruno; Vasques, Ana Carolina Junqueira; Stabe, Christiane França Camargo; Pareja, José Carlos; Rosado, Lina Enriqueta Frandsen Paez de Lima; Queiroz, Elaine Cristina de; Tambascia, Marcos Antonio

    2009-03-01

    To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%). The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.

  12. Relationship of visfatin level to pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index in overweight women who performed hydraulic resistance exercise.

    Science.gov (United States)

    Ha, Chang Ho; Swearingin, Brenda; Jeon, Yong Kyun

    2015-09-01

    [Purpose] This study aimed to examine the correlation of visfatin level to pancreatic endocrine hormone level, homeostasis model assessment of insulin resistance (HOMA-IR) index, and HOMA β-cell index in hydraulic resistance exercise. Furthermore, it investigated the relationship between visfatin level and other variables affected by exercise in overweight women. [Subjects and Methods] The exercise group trained for 12 weeks, 70 minutes/day, 5 days/week. Visfatin level, pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index were measured before and after the intervention. Based on the blood insulin and glucose concentrations, HOMA-IR index, the indicator of insulin resistance, and HOMA β-cell index, the indicator of insulin secretion level, were assessed. [Results] Interaction effects on visfatin level, insulin level, HOMA-IR index, and HOMA β-cell index were observed. Interaction effects on glucagon and glucose levels were not observed between the intervention groups. The correlations of visfatin level to insulin, glucagon, and glucose levels, and HOMA-IR and HOMA β-cell indexes were not significant for any of the subjects. [Conclusion] Therefore, the 12-week resistance exercise affected body composition, visfatin level, insulin level, HOMA-IR index, and HOMA β-cell index. Finally, visfatin was not related to insulin, glucagon, and glucose levels, and HOMA-IR and HOMA β-cell indexes.

  13. [Association between VDR gene polymorphisms and HOMA index for prediabetes in Ningxia].

    Science.gov (United States)

    Liao, Sha; He, Jun; Li, Xiaoxia; Xu, Honexia; Liu, Xiuying; Zhao, Yi; Zhang, Yuhong

    2016-03-01

    To explore the association between the vitamin D receptor (VDR) gene polymorphisms and HOMA index in prediabetes. On the basis of a cross-sectional study which was conducted in Ningxia during 2008-2012, 339 controls and 468 subjects with prediabetes were selected according to ADA diabetes diagnosis standards. Anthropometric data and blood samples were collected in the field investigation. Blood biochemistry analyses and insulin determination were carried out in the laboratory. The whole blood DNA was extracted for genotyping. The BMI, WC, FPG and HOMA-IR of individuals with prediabetes were higher than those of the controls, while the HOMA-B and HOMA-S in cases were lower than those of the controls (P HOMA-B than bb carrier, and they showed significantly higher HOMA-S than bb carriers (P HOMA-B index was the risk factor of prediabetes in individuals who carried genotype BB/Bb for BsmI and genotype FF/Ff/ff for FokI (OR > 1 , P HOMA-S and HOM-IR were also the risk factors of prediabetes (OR > 1, P HOMA index in prediabetes. The BsmI polymorphism seemed to influence HOMA-B, while the FokI polymorphism influence HOMA-B and HOMA-IR at different levels.

  14. Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2 with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans

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    Young Seok Song

    2016-05-01

    Full Text Available BackgroundThe original homeostasis model assessment (HOMA1 and the updated HOMA model (HOMA2 have been used to evaluate insulin resistance (IR and β-cell function, but little is known about the usefulness of HOMA2 for the prediction of diabetes in Koreans. The aim of this study was to demonstrate the usefulness of HOMA2 as a predictor of type 2 diabetes mellitus in Koreans without diabetes.MethodsThe study population consisted of 104,694 Koreans enrolled at a health checkup program and followed up from 2001 to 2012. Participants were divided into a normal glucose tolerance (NGT group and a pre-diabetes group according to fasting glucose and glycosylated hemoglobin levels. Anthropometric and laboratory data were measured at the baseline checkup, and HOMA values were calculated at the baseline and follow-up checkups. The hazard ratios (HRs of the HOMA1 and HOMA2 values and the prevalence of diabetes at follow-up were evaluated using a multivariable Cox proportional hazards model and Kaplan-Meier analysis.ResultsAfter adjusting for several diabetes risk factors, all of the HOMA values except 1/HOMA1-β and 1/HOMA2-β in the NGT group were significant predictors of the progression to diabetes. In the NGT group, there was no significant difference in HOMA1-IR (HR, 1.09; 95% confidence interval [CI], 1.04 to 1.14 and HOMA2-IR (HR, 1.11; 95% CI, 1.04 to 1.19. However, in the pre-diabetes group, 1/HOMA2-β was a more powerful marker (HR, 1.29; 95% CI, 1.26 to 1.31 than HOMA1-IR (HR, 1.23; 95% CI, 1.19 to 1.28 or 1/HOMA1-β (HR, 1.14; 95% CI, 1.12 to 1.16. In the non-diabetic group (NGT+pre-diabetes, 1/HOMA2-β was also a stronger predictor of diabetes (HR, 1.27; 95% CI, 1.25 to 1.29 than HOMA1-IR (HR, 1.14; 95% CI, 1.12 to 1.15 or 1/HOMA1-β (HR, 1.13; 95% CI, 1.11 to 1.14.ConclusionHOMA2 is more predictive than HOMA1 for the progression to diabetes in pre-diabetes or non-diabetic Koreans.

  15. Fundamentos de la programación orientada a objetos

    OpenAIRE

    Cachero Castro, Cristina; Ponce de León Amador, Pedro José

    2006-01-01

    Fundamentos de la programación orientada a objetos: ABSTRACCIÓN, OCULTACIÓN DE INFORMACIÓN, ENCAPSULACIÓN. Conceptos específicos de P.O.O: objetos, clases, paso de mensajes, herencia, polimorfismo.

  16. Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans

    OpenAIRE

    Song, Young Seok; Hwang, You-Cheol; Ahn, Hong-Yup; Park, Cheol-Young

    2016-01-01

    Background The original homeostasis model assessment (HOMA1) and the updated HOMA model (HOMA2) have been used to evaluate insulin resistance (IR) and ?-cell function, but little is known about the usefulness of HOMA2 for the prediction of diabetes in Koreans. The aim of this study was to demonstrate the usefulness of HOMA2 as a predictor of type 2 diabetes mellitus in Koreans without diabetes. Methods The study population consisted of 104,694 Koreans enrolled at a health checkup program and ...

  17. Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans

    OpenAIRE

    Young Seok Song; You-Cheol Hwang; Hong-Yup Ahn; Cheol-Young Park

    2016-01-01

    BackgroundThe original homeostasis model assessment (HOMA1) and the updated HOMA model (HOMA2) have been used to evaluate insulin resistance (IR) and β-cell function, but little is known about the usefulness of HOMA2 for the prediction of diabetes in Koreans. The aim of this study was to demonstrate the usefulness of HOMA2 as a predictor of type 2 diabetes mellitus in Koreans without diabetes.MethodsThe study population consisted of 104,694 Koreans enrolled at a health checkup program and fol...

  18. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome - Brazilian Metabolic Syndrome Study (BRAMS)

    OpenAIRE

    Geloneze, B; Vasques, ACJ; Stabe, CFC; Pareja, JC; Rosado, LEFPD; de Queiroz, EC; Tambascia, MA

    2009-01-01

    Objective: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Methods: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 9011 percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. Results: In the he...

  19. Carrying capacity of Chaetoceros gracilis in Homa Lagoon and the ...

    African Journals Online (AJOL)

    The possibility for nutrient limitation to affect C. gracilis was assessed from two different ecosystems (Izmir Bay and Homa Lagoon). Our goal was to determine the growth rate of all nutrients and the maximum levels of the C. gracilis phytoplankton biomass (the maximum biomass carrying capacity) on the extent of its full ...

  20. [HOMA-IR in patients with chronic hepatitis C].

    Science.gov (United States)

    Botshorishvili, T; Vashakidze, E

    2012-02-01

    The aim of investigation was to study the frequency of IR in type of viral hepatitis C, correlation with the degree of hepatic lesion and liver cirrhosis. 130 patients were investigated: 20 with acute hepatitis C; 38 with chronic hepatitis C; 72 with cirrhosis: among them 10 with Stage A, 14 with Stage B and 48 with Stage C. Also we used 30 healthy people as the controls. The study demonstrates significant changes of insulin, glucose, HOMA-IR type of viral hepatitis C, correlation with the degree of hepatic lesion and liver cirrhosis. In patients with liver cirrhosis levels of HOMA-IR is higher than in patients with chronic hepatitis C. In patients with acute hepatitis C levels of HOMA-IR was normal as in the control group. The results showed that various types of chronic viral hepatitis C and stages of cirrhosis set to increase HOMA-IR versus the controls., which were the most prominent in cases of severe hepatic lesion, which indicates that insulin resistance is a frequent companion of CHC.

  1. Relationship between elevated triglyceride levels with the increase of HOMA-IR and HOMA-β in healthy children and adolescents with normal weight.

    Science.gov (United States)

    Simental-Mendía, Luis E; Castañeda-Chacón, Argelia; Rodriguez-Morán, Martha; Aradillas-García, Celia; Guerrero-Romero, Fernando

    2015-05-01

    To test the hypothesis that mildly elevated triglyceride levels are associated with the increase of homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) indices in healthy children and adolescents with normal weight, we conducted a cross-sectional population study. Based on fasting triglyceride levels, participants were allocated into groups with and without triglyceride levels ≥1.2 mmol/L. Normal weight was defined by body mass index between the 15th and 85th percentiles, for age and gender. Insulin resistance and insulin secretion were estimated using HOMA-IR and HOMA-β indices. A total of 1660 children and adolescents were enrolled, of them 327 (19.7%) with mildly elevated triglycerides. The multivariate linear regression analysis showed that mildly elevated triglyceride levels in children were associated with HOMA-IR (β = 0.214, p HOMA-β (β = 0.139, p = 0.001), systolic (β = 0.094, p = 0.01), and diastolic blood pressure (β = 0.102, p = 0.007), whereas in adolescents, HOMA-IR (β = 0.267, p HOMA-β (β = 0.154, p HOMA-IR and HOMA-β indices in healthy children and adolescents with normal weight.

  2. Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study.

    Science.gov (United States)

    Ahuja, Vasudha; Kadowaki, Takashi; Evans, Rhobert W; Kadota, Aya; Okamura, Tomonori; El Khoudary, Samar R; Fujiyoshi, Akira; Barinas-Mitchell, Emma J M; Hisamatsu, Takashi; Vishnu, Abhishek; Miura, Katsuyuki; Maegawa, Hiroshi; El-Saed, Aiman; Kashiwagi, Atsunori; Kuller, Lewis H; Ueshima, Hirotsugu; Sekikawa, Akira

    2015-02-01

    At the same level of BMI, white people have less visceral adipose tissue (VAT) and are less susceptible to developing type 2 diabetes than Japanese people. No previous population-based studies have compared insulin resistance and insulin secretion between these two races in a standardised manner that accounts for VAT. We compared HOMA-IR, HOMA of beta cell function (HOMA-β%) and disposition index (DI) in US white men and Japanese men in Japan. We conducted a population-based, cross-sectional study, comprising 298 white men and 294 Japanese men aged 40-49 years without diabetes. Insulin, glucose, VAT and other measurements were performed at the University of Pittsburgh. We used ANCOVA to compare geometric means of HOMA-IR, HOMA-β% and DI, adjusting for VAT and other covariates. White men had higher HOMA-IR, HOMA-β% and DI than Japanese men, and the difference remained significant (p HOMA-IR, HOMA-β% and DI were significantly higher in white men even after further adjustment for BMI, impaired fasting glucose and other risk factors. The higher VAT-adjusted DI in white men than Japanese men may partly explain lower susceptibility of white people than Japanese people to developing type 2 diabetes. The results, however, should be interpreted with caution because the assessment of insulin indices was made using fasting samples and adjustment was not made for baseline glucose tolerance. Further studies using formal methods to evaluate insulin indices are warranted.

  3. Oculomotricidade e seus fundamentos Ocular motility: foundations

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    Harley E. A. Bicas

    2003-10-01

    Full Text Available Partindo-se de um circuito esquemático relacionando os sistemas sensorial (visual binocular e oculomotor, cujos defeitos em vias aferentes ou eferentes, ou de suas interações, explicam o aparecimento dos estrabismos e suas conseqüências, são examinados os fundamentos e referenciais da movimentação ocular. Apresentam-se os conceitos de eixos e planos, centro de massa e de rotação, definem-se os movimentos monoculares de translação e de rotação e os binoculares de versões e vergências. É também referida a função dos centros de comando para movimentos voluntários e reflexos, a dos núcleos oculomotores e a respectiva inervação aos músculos oculares externos. Numa segunda parte (fisiologia da musculatura ocular extrínseca são comentadas as atividades de contração e relaxamento e a importância da lei de Sherrington. Voltando-se ao conceito de posição primária do olhar e dos referenciais das rotações, menciona-se a diversidade de vários sistemas de medidas. Em seguida, são analisadas as ações musculares rotacionais com bases no plano de ação muscular e na distribuição anatômica dos músculos, levando a resultados em posição primária do olhar e nas outras. Os efeitos de fáscias e membranas intermusculares são também comentados, terminando-se com a concepção moderna sobre as ações musculares (ação simultânea de todos os músculos em quaisquer das posições oculares. Com os condicionantes da lei de Hering, desenvolve-se o conceito de posições diagnósticas (das disfunções oculomotoras, diferentemente do clássico: os músculos são considerados em pares, de acordo às suas ações predominantes ___ horizontais (retos horizontais, verticais (retos verticais ou torcionais (oblíquos. Em cada qual devem ser comparadas as ações em condições diametralmente opostas de fixação ocular e posições do olhar (por exemplo, supradextroversão na fixação com o olho direito e infralevoversão na fixa

  4. Study of beta-cell function (by HOMA model) in metabolic syndrome.

    Science.gov (United States)

    Garg, M K; Dutta, M K; Mahalle, Namita

    2011-07-01

    The clustering of cardiovascular risk factors is termed the metabolic syndrome (MS), which strongly predict risk of diabetes and cardiovascular disease. Many studies implicate insulin resistance (IR) in the development of diabetes, but ignore the contribution of beta-cell dysfunction. Hence, we studied beta-cell function, as assessed by HOMA model, in subjects with MS. We studied 50 subjects with MS diagnosed by IDF criteria and 24 healthy age- and sex-matched controls. Clinical evaluation included anthropometry, body fat analysis by bioimpedance, biochemical, and insulin measurement. IR and secretion were calculated by HOMA model. Subjects with MS had more IR (HOMA-IR) than controls (3.35 ± 3.14 vs. 1.76 ± 0.53, P = 0.029) and secreted less insulin (HOMA-S) than controls (66.80 ± 69.66 vs. 144.27 ± 101.61, P = 0.0003), although plasma insulin levels were comparable in both groups (10.7 ± 10.2 vs. 8.2 ± 2.38, P = 0.44). HOMA-IR and HOMA-S were related with number of metabolic abnormalities. HOMA-IR was positively associated with body mass index, waist hip ratio, body fat mass, and percent body fat. HOMA-S was negatively associated with waist hip ratio, fasting plasma glucose and total cholesterol and positively with basal metabolic rate. Percent body fat was an independent predictor of HOMA-IR and waist hip ratio of HOMA-S in multiple regression analysis. Subjects with MS have increased IR and decreased insulin secretion compared with healthy controls. Lifestyle measures have been shown to improve IR, insulin secretion, and various components and effects of MS. Hence, there is an urgent need for public health measures to prevent ongoing epidemic of diabetes and cardiovascular disease.

  5. Variability of HOMA and QUICKI insulin sensitivity indices.

    Science.gov (United States)

    Žarković, Miloš; Ćirić, Jasmina; Beleslin, Biljana; Stojković, Mirjana; Savić, Slavica; Stojanović, Miloš; Lalić, Tijana

    2017-07-01

    Assessment of insulin sensitivity based on a single measurement of insulin and glucose, is both easy to understand and simple to perform. The tests most often used are HOMA and QUICKI. The aim of this study was to assess the biological variability of estimates of insulin sensitivity using HOMA and QUICKI indices. After a 12-h fast, blood was sampled for insulin and glucose determination. Sampling lasted for 90 min with an intersample interval of 2 min. A total of 56 subjects were included in the study, and in nine subjects sampling was done before and after weight reduction, so total number of analyzed series was 65. To compute the reference value of the insulin sensitivity index, averages of all 46 insulin and glucose samples were used. We also computed point estimates (single value estimates) of the insulin sensitivity index based on the different number of insulin/glucose samples (1-45 consecutive samples). To compute the variability of point estimates a bootstrapping procedure was used using 1000 resamples for each series and for each number of samples used to average insulin and glucose. Using a single insulin/glucose sample HOMA variability was 26.18 ± 4.31%, and QUICKI variability was 3.30 ± 0.54%. For 10 samples variability was 11.99 ± 2.22% and 1.62 ± 0.31% respectively. Biological variability of insulin sensitivity indices is significant, and it can be reduced by increasing the number of samples. Oscillations of insulin concentration in plasma are the major cause of variability of insulin sensitivity indices.

  6. Six months training alone or combined with diet alters HOMA-AD, HOMA-IR and plasma and adipose tissue adiponectin in obese women.

    Science.gov (United States)

    Lakhdar, Nadia; Denguezli, Myriam; Zaouali, Monia; Zbidi, Abdelkrim; Tabka, Zouhair; Bouassida, Anissa

    2014-01-01

    We investigate the effect of 6 months aerobic training alone or in combination with diet on adiponectin in circulation and in adipose abdominal tissue (AT) in obese women. Twenty obese subjects were randomized into a 24 weeks intervention: 1) training (TR) and 2) training and diet (TRD). Blood samples were collected at baseline, after 12 wk and 24 wk. AT biopsies were obtained only at baseline and after 24 wk. In the TRD group the fat loss was after 12 wk -13.74% (pHOMA-IR and HOMA-AD for assessing insulin resistance were strongly affected by protocols. HOMA-IR decreased (pHOMA-AD increased in both groups after 12 (pHOMA-IR.

  7. HOMA-S is associated with greater HbA1c reduction with a GLP-1 analogue in patients with type 2 diabetes.

    Science.gov (United States)

    Heald, A H; Narayanan, R P; Lowes, D; Jarman, E; Onyekwelu, E; Qureshi, Z; Laing, I; Anderson, S G

    2012-07-01

    Exenatide, a glucagon-like peptide-1 (GLP-1) analogue, is an effective glucoregulator for treating overweight individuals, not at target HbA1 c. This prospective study aimed to determine whether estimates of beta cell function (HOMA-B) and insulin sensitivity (HOMA-S) predict response to Exenatide treatment.Prospective data on 43 type 2 diabetes patients were collected for up to 2.8 years in UK primary care. HOMA-B and HOMA-S were estimated prior to initiating Exenatide, with monitoring of cardio-metabolic risk factors.Mean (SD) age and BMI pre-treatment were 54.1±10.5 years and 35.7±7.5 kg/m2 respectively. HbA1c decreased (mean reduction 0.9%, p=0.04; p for trend=0.01) in 61% of patients. In univariate analyses, HOMA-S as a measure of insulin sensitivity was inversely (β=- 0.41, p 0.009) related to change in HbA1c, with no relation for HOMA-B.In a random effects regression model that included age at baseline, weight, LDL-C, HDL-C and triglycerides, change in HbA1c (β= - 0.14, pHOMA-S were 45% more likely to have a fall in HbA1c with an odds ratio (OR) of 0.55 (95% CI 0.47-0.66) p<0.0001 (log likelihood ratio for the model χ2=71.6, p<0.0001).Patients with greater measured insulin sensitivity achieve greater reduction in HbA1c with Exenatide. Determination of insulin sensitivity may assist in guiding outcome expectation in overweight patients treated with GLP-1 analogues. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

  8. HOMA-AD in Assessing Insulin Resistance in Lean Noncirrhotic HCV Outpatients.

    Science.gov (United States)

    Michalczuk, Matheus Truccolo; Kappel, Camila Rippol; Birkhan, Oscar; Bragança, Ana Carolina; Alvares-da-Silva, Mário Reis

    2012-01-01

    Introduction. There is an association between HCV and insulin resistance (IR), which is currently assessed by HOMA-IR. There is evidence that HOMA-adiponectin (HOMA-AD) is more accurate, but its role in HCV patients is unknown. The purpose of this study was to evaluate IR in an HCV sample and controls, in order to compare the accuracy of HOMA-IR and HOMA-AD. Methods. Ninety-four HCV outpatients aged IR was estimated by HOMA-IR and HOMA-AD. Results. The groups were similar regarding sex and BMI, but the HCV patients were older. The median insulin level was higher in the HCV group (8.6 mU/mL (6.5-13.7) versus 6.5 (4.3-10.7), P = 0.004), as was median HOMA-IR (1.94 (1.51 to 3.48) versus 1.40 (1.02 to 2.36), P = 0.002) and the prevalence of IR (38.3% versus 10.3% (P = 0.009)). No differences were found in adiponectin levels (P = 0.294) and HOMA-AD (P = 0.393). Conclusion. IR is highly prevalent even in low-risk HCV outpatients. Adiponectin is not influenced by the presence of HCV. HOMA-AD does not seem to be useful in assessing IR in HCV patients.

  9. Use of HOMA-IR in hepatitis C.

    Science.gov (United States)

    Eslam, M; Kawaguchi, T; Del Campo, J A; Sata, M; Khattab, M Abo-Elneen; Romero-Gomez, M

    2011-10-01

    Chronic infection with hepatitis C virus (HCV) can induce insulin resistance (IR) in a genotype-dependent manner and contributes to steatosis, progression of fibrosis and resistance to interferon plus ribavirin therapy. Our understanding of HCV-induced IR has improved considerably over the years, but certain aspects concerning its evaluation still remain elusive to clinical researchers. One of the most important issues is elucidating the ideal method for assessment of IR in the setting of hepatitis C. The hyperinsulinaemic euglycaemic clamp is the gold standard method for determining insulin sensitivity, but is impractical as it is labour intensive and time-consuming. To date, all human studies except for four where IR was evaluated in the HCV setting, an estimation of IR has been used rather than direct measurements of insulin-mediated glucose uptake. The most commonly used estimation in the HCV population is the homeostasis model assessment of insulin resistance (HOMA-IR) which is calculated from a single measurement of fasting insulin and glucose. In this article, we review the use and reporting of HOMA in the literature and provide guidance on its appropriate as well as inappropriate use in the hepatitis setting. © 2011 Blackwell Publishing Ltd.

  10. Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents.

    Science.gov (United States)

    Wang, Lingli; Wang, Huiyan; Wen, Huaikai; Tao, Hongqun; Zhao, Xiaowei

    2016-07-01

    The objective of this study was to examine the cross-sectional relationship between homeostasis model assessment for insulin resistance (HOMA-IR) and serum 25-hydroxyvitamin D (25-OHD) level in Chinese children and adolescents. Anthropometric indices, lipid metabolic profile, and serum levels of glucose, insulin and 25-OHD were determined among 278 healthy prepubertal and pubertal, normal and overweight/obese children and adolescents aged 8-18 years between March 2014 and February 2015. HOMA-IR was significantly different across vitamin D statuses (pHOMA-IR negatively correlated with serum 25-OHD level for all subjects (R2=0.148, pHOMA-IR and BMI and serum 25-OHD level (R2=0.654, pHOMA-IR. Our findings supported that lower vitamin D status is strongly associated with worse HOMA-IR.

  11. Diferentes aferições do diâmetro abdominal sagital e do perímetro da cintura na predição do HOMA-IR Mediciones distintas del diámetro abdominal sagital y del perímetro de la cintura en la predicción del HOMA-IR Different measurements of the sagittal abdominal diameter and waist perimeter in the prediction of HOMA-IR

    Directory of Open Access Journals (Sweden)

    Ana Carolina Junqueira Vasques

    2009-11-01

    Full Text Available FUNDAMENTO: A correlação entre aumento de gordura visceral e de resistência à insulina coloca o diâmetro abdominal sagital e o perímetro da cintura como instrumentos potenciais para a predição de resistência à insulina. OBJETIVO: Avaliar a reprodutibilidade de diferentes aferições do diâmetro abdominal sagital e do perímetro da cintura e analisar o poder discriminante dos mesmos para predizer resistência à insulina. MÉTODOS: Foram avaliados 190 homens adultos. O diâmetro abdominal sagital (menor cintura, maior diâmetro abdominal, nível umbilical e ponto médio entre as cristas ilíacas e o perímetro da cintura (nível umbilical, menor cintura, imediatamente acima da crista ilíaca e ponto médio entre a crista ilíaca e a última costela foram aferidos em quatro locais diferentes. A resistência à insulina foi avaliada pelo índice HOMA-IR. RESULTADOS: Todas as medidas apresentaram correlação intraclasse de 0,986-0,999. Tanto o diâmetro abdominal sagital aferido na menor cintura (r=0,482 e AUC=0,739±0,049 como o perímetro da cintura aferido no ponto médio entre a última costela e a crista ilíaca (r=0,464 e AUC=0,746±0,05 apresentaram maiores correlações com o HOMA-IR, bem como um melhor poder discriminante para o HOMA-IR segundo a análise ROC (pFUNDAMENTO: La correlación entre aumento de la grasa visceral y de la resistencia a la insulina pone el diámetro abdominal sagital y el perímetro de la cintura como los instrumentos potenciales para la predicción de resistencia a la insulina. OBJETIVO: Evaluar la reproductibilidad de distintas mediciones del diámetro abdominal sagital y del perímetro de la cintura y analizar el poder discriminante de las mismas para predecir resistencia a la insulina. MÉTODOS: Se evaluaron a 190 varones adultos. El diámetro abdominal sagital (menor cintura, mayor diámetro abdominal, nivel umbilical y punto promedio entre las crestas ilíacas y el perímetro de la cintura (nivel

  12. Relationship of visfatin level to pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index in overweight women who performed hydraulic resistance exercise

    OpenAIRE

    Ha, Chang Ho; Swearingin, Brenda; Jeon, Yong Kyun

    2015-01-01

    [Purpose] This study aimed to examine the correlation of visfatin level to pancreatic endocrine hormone level, homeostasis model assessment of insulin resistance (HOMA-IR) index, and HOMA β-cell index in hydraulic resistance exercise. Furthermore, it investigated the relationship between visfatin level and other variables affected by exercise in overweight women. [Subjects and Methods] The exercise group trained for 12 weeks, 70 minutes/day, 5 days/week. Visfatin level, pancreatic endocrine h...

  13. Pruebas de Software. Fundamentos y Técnicas

    OpenAIRE

    Sánchez Peño, José Manuel

    2015-01-01

    Este proyecto estudia los fundamentos y las técnicas de las pruebas de software. Veremos lo importante que pueden llegar a ser las pruebas, mostrando diferentes desastres causados por fallos en el software. También estudiaremos las diferentes herramientas que se utilizan para llevar a cabo la gestión, administración y ejecución de estas pruebas. Finalmente aplicaremos los conceptos estudiados mediante un caso práctico. Crearemos los casos de prueba funcionales basándonos en las espec...

  14. Serum uric acid levels are associated with homeostasis model assessment in obese nondiabetic patients: HOMA and uric acid.

    Science.gov (United States)

    Elizalde-Barrera, Cesar I; Estrada-García, Teresa; Lozano-Nuevo, Jose J; Garro-Almendaro, Ana K; López-Saucedo, Catalina; Rubio-Guerra, Alberto F

    2017-10-01

    Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid. The aim of this study was to evaluate whether there is a correlation between serum uric acid levels with homeostatic model assessment (HOMA) 1 in nondiabetic patients. We evaluated 88 nondiabetic patients, in whom uric acid levels were measured, in all of them HOMA of β-cell function (HOMA 1B) and HOMA of insulin resistance (HOMA 1IR) scores were performed. Uric acid and the HOMA 1 values were correlated using the Pearson coefficient. We did not find any correlation between uric acid levels with both HOMA 1B ( r = 0.102, p = 0.343), nor with HOMA 1IR ( r = 0.158, p = 0.117). When patients were analyzed by sex, we found a significant correlation with HOMA 1IR (0.278, p = 0.01), but not with HOMA 1B (0.138, p = 0.257) in women. We found a correlation with HOMA 1B in men ( r = 0.37, p = 0.044), but not with HOMA 1IR: 0.203, p = 0.283. The analysis performed based on body mass index did not show correlation in the patients with normal weight, (HOMA 1B r = 0.08, p = 0.5, HOMA 1IR = 0.034, p = 0.793), nor in the patients who were overweight (HOMA 1B: r = 0.05, p = 0.76, HOMA 1IR r = 0.145, p = 0.43). However, a significant correlation between uricemia with both HOMA 1B (0.559, p uric acid levels seem to be associated with insulin resistance in women, and in obese patients, but not in nonobese men. Uric acid also modifies β-cell function in men and in obese patients.

  15. Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes.

    Science.gov (United States)

    Sarafidis, P A; Lasaridis, A N; Nilsson, P M; Pikilidou, M I; Stafilas, P C; Kanaki, A; Kazakos, K; Yovos, J; Bakris, G L

    2007-09-01

    The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients of variation between the two visits were estimated to assess their reproducibility. HOMA-IR index was strongly and inversely correlated with the basic IS clamp index, the M-value (r=-0.572, PHOMA-IR and QUICKI indices were positively correlated with the M-value (r=0.342, PHOMA-IR was the best fit of clamp-derived IS. Coefficients of variation between the two visits were 23.5% for HOMA-IR, 19.2% for 1/HOMA-IR, 7.8% for QUICKI and 15.1% for McAuley's index. In conclusion, HOMA-IR, 1/HOMA-IR and QUICKI are valid estimates of clamp-derived IS in patients with hypertension and type II diabetes, whereas the validity of McAuley's index needs further evaluation. QUICKI displayed better reproducibility than the other indices.

  16. Instrumental neutron activation analysis of carbonatites from Homa Mountain, Kenya

    International Nuclear Information System (INIS)

    Ohde, S.

    2004-01-01

    Twenty eight (major and trace) elements including eight rare earth elements (REEs) in African carbonatite samples were determined by instrumental neutron activation analysis. The geochemical behavior of trace elements was studied in relation to the order of carbonatite intrusion from C1 to C4 through C2 and C3 at Homa Mountain, Kenya. The enrichment of Mn, Fe, Sr, Ba, Th, U and REE is found in the sixteen carbonatites examined in this study. The general increase in the concentrations of Na, Sc, Mn, Sb, Ba, Th, U and REE occurs from C1 to C4 through C2 and C2c, but C3 carbonatite shows a different pattern. The C3 carbonatite is extraordinarily enriched in Mn, Fe and Ba and is highly enriched in Cr, As, Sb and Th. The chondrite-normalized REE distribution pattern of the C3 carbonatite is not rich in the light REE. Strong fractionation between light and heavy REEs is found in the carbonatites, and moderate fractionation in the two alkalic igneous rock samples. In order to evaluate partitioning of REEs into carbonate, oxide and other mineral fractions, a selective chemical leaching technique on carbonatites was applied and is discussed. (author)

  17. Buddhist Ritual from Syntax to Cognition: Insight Meditation and Homa

    Directory of Open Access Journals (Sweden)

    Richard K. Payne

    2016-08-01

    Full Text Available The concept of “ritual syntax” is developed by relating it to cognitive studies of ritual, providing a fuller theoretical basis. Developing theoretical grounding requires differentiating between the members of five pairs of concepts: production is not the same as analysis, syntax is not the same as semantics, ritual is not the same as the mental, cognition is not the same as the mental, and syntax is not the same as language. These distinctions help avoid overly strong interpretations of the analogy between ritual and language. A discussion of “ritual” suggests that it is best conceptualized in terms of multiple scalar characteristics with degrees of ritualization. Two Buddhist practices, insight meditation and homa, are introduced as instances for the cognitive study of ritual. Syntax involves not simply ordering of elements, but also hierarchical organization of those elements. While syntax allows sentential elements to move within a sentence, ritual tends toward invariance. Invariance seems to contradict the claim that ritual is syntactically organized. However, rituals are often modeled on ordinary activities, producing a kind of “semantic” motivation for invariance.

  18. [Normal plasma insulin and HOMA values among Chilean children and adolescents].

    Science.gov (United States)

    Barja, Salesa; Arnaiz, Pilar; Domínguez, Angélica; Villarroel, Luis; Cassis, Berta; Castillo, Oscar; Salomó, Gianina; Farías, Marcelo; Goycoolea, Manuela; Quiroga, Teresa; Mardones, Francisco

    2011-11-01

    Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years, according to sex and puberal maturation. A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropometry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. The reference group included only subjects with normal body mass index and fasting blood glucose (n = 1,192). Girls had higher insulin and HOMA values than boys (12.5 ± 6.0 and 9.1 ± 4.9 μϋ/mL (p HOMA mean values than subjects with Tanner III and IV (9.0 ± 4.3 and 12.5 ± 6.2μϋ/ml (p HOMA distributions according to sex and maturation, was selected as the upper cut-off point to identify individuals with insulin resistance. HOMA cutoff point for Tanner I and II boys was 3.2, for Tanner I and II girls was 4.1, for Tanner III and IV boys was 4.2 and for Tanner III and IV girls was 5.0.

  19. Efek Hipoglikemik Kecambah Beras Merah pada Tikus yang Diinduksi STZ-NA dengan Parameter Kadar Insulin, Indeks HOMA-IR dan HOMA β

    Directory of Open Access Journals (Sweden)

    Nurhidajah Nurhidajah

    2017-02-01

    Full Text Available The process of germination of grains such as rice, could increase some nutritional values of  amino acids and dietary fiber. Red rice and its sprouts are believed to be able to decrease blood glucose in patients with diabetes mellitus (DM. The aim of this study was to evaluate the hypoglycemic effect of red rice sprouts in STZ-NA induced diabetic rats on blood glucose level, insulin level, and HOMA-IR and HOMA-β index. This experimental study was conducted based on randomized post test only control group design using 24 male Wistar rats aged 2.5 months. Rats were divided into 4 groups, one group without induction of STZ-NA fed with a standard diet (control and three groups of STZ- NA induced with a standard diet, red rice and red rice germ. Experiments were conducted for 6 weeks. The results showed that sprouted red rice lowered blood glucose levels by 61.88 % and the value of HOMA-IR (insulin resistance parameters by 56.82%. Insulin level increased by 16.35 % and HOMA-β by 763.6 %. This study showed that red rice germ was able to decrease blood glucose levels and increase insulin resistance of DM rats and the strength of the pancreatic beta cells.   ABSTRAK Proses perkecambahan biji-bijian seperti beras, dapat meningkatkan beberapa nilai gizi seperti asam amino dan serat pangan. Beras merah dan kecambahnya diyakini mampu menurunkan glukosa darah pada penderita diabetes melitus (DM. Tujuan penelitian ini adalah mengevaluasi efek hipoglikemik kecambah beras merah pada tikus diabetes yang diinduksi STZ-NA terhadap kadar glukosa darah, insulin, serta indeks HOMA-IR dan HOMA β. Penelitian ini bersifat eksperimental in vivo pada hewan coba tikus Wistar jantan usia 2,5 bulan sebanyak 24 ekor dengan desain penelitian randomized post test only control group. Tikus dibagi menjadi 4 kelompok, masing-masing 1 kelompok tanpa induksi STZ-NA dengan diet standar dan 3 kelompok diinduksi STZ-NA dengan diet standar, beras merah dan kecambah beras merah

  20. Baterías recargables de litio: fundamentos y materiales

    OpenAIRE

    García-Alvarado, F.

    1996-01-01

    Se presenta una breve revisión sobre los materiales inorgánicos que pueden ser utilizados como electrodo positivo en baterías recargables de litio comparándose éstos entre sí en función de las prestaciones esperadas u obtenidas. Para una correcta comprensión de la química de estado sólido involucrada en este campo se ha dedicado una parte de este artículo a explicar el fundamento de las baterías recargables de litio intentando relacionar claramente los parámetros característicos de estas a ba...

  1. Lower HOMA-ОІ values are detected among individuals with variant ...

    African Journals Online (AJOL)

    Raden Sunita

    2015-06-06

    Jun 6, 2015 ... Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease involving both ... Homeostasis Model Assessment b (HOMA-b) values of AA genotype ... were excluded in this research if fasting blood glucose.

  2. The association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values.

    Science.gov (United States)

    Yoldemir, T; Yavuz, D G

    2014-06-01

    To determine the association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values in postmenopausal women. Methods One hundred healthy postmenopausal women were included in a cross-sectional study. Venous blood was collected after an overnight fast and 25-hydroxyvitamin D, glucose and insulin levels were measured. HOMA-IR was calculated. Bone mineral density was measured with a dual X-ray absorptiometer. There was no difference in serum 25-hydroxyvitamin D levels and HOMA-IR values between the two groups. A weak positive correlation between serum 25-hydroxyvitamin D levels and osteopenia was detected. Insulin resistance had a weak negative association with osteopenia. The correlations between osteopenia and serum 25-hydroxyvitamin D levels and HOMA-IR values were weak among early postmenopausal women.

  3. The Associations Between Increasing Degrees of HOMA-IR and Measurements of Adiposity Among Euglycemic U.S. Adults.

    Science.gov (United States)

    Boyer, William R; Johnson, Tammie M; Fitzhugh, Eugene C; Richardson, Michael R; Churilla, James R

    2016-03-01

    The purpose of this study was to examine the associations between increasing degrees of insulin resistance (using the homeostatic model assessment of insulin resistance [HOMA-IR]) and two measures of adiposity in a nationally representative sample of euglycemic U.S. adults. Sample included adult participants (≥ 20 years of age) [N = 1586 (body mass index, BMI model), N = 1577 (waist circumference, WC model)] from the 1999-2004 National Health and Nutrition Examination Survey (NHANES). HOMA-IR was categorized into quartiles. BMI and WC were examined continuously as the dependent variables. Following adjustment for covariates, those with HOMA-IR values in the second, third, and fourth quartiles had significantly higher BMIs (P HOMA-IR (P HOMA-IR and BMI (R(2) = 0.4171, P HOMA-IR and WC (R(2) = 0.4826, P HOMA-IR value is associated with higher BMI and WC values in euglycemic subjects.

  4. Variability in HOMA-IR, lipoprotein profile and selected hormones in young active men.

    Science.gov (United States)

    Keska, Anna; Lutoslawska, Grazyna; Czajkowska, Anna; Tkaczyk, Joanna; Mazurek, Krzysztof

    2013-01-01

    Resistance to insulin actions is contributing to many metabolic disturbances. Such factors as age, sex, nutrition, body fat, and physical activity determine body insulin resistance. Present study attempted to asses insulin resistance and its metabolic effects with respect to energy intake in young, lean, and active men. A total of 87 men aged 18-23 participated in the study. Plasma levels of glucose, insulin, lipoproteins, cortisol, and TSH were determined. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and calculated using homeostatic model. The median value of HOMA-IR (1.344) was used to divide subjects into two groups. Men did not differ in anthropometric parameters, daily physical activity, and plasma TSH and cortisol levels. However, in men with higher HOMA-IR significantly lower daily energy intake was observed concomitantly with higher TG, TC, and HDL-C concentrations in plasma versus their counterparts with lower HOMA-IR. Exclusively in subjects with higher HOMA-IR significant and positive correlation was noted between HOMA-IR and TC and LDL-C. We concluded that despite a normal body weight and physical activity, a subset of young men displayed unfavorable changes in insulin sensitivity and lipid profile, probably due to insufficient energy intake.

  5. [Reliability of HOMA-IR for evaluation of insulin resistance during perioperative period].

    Science.gov (United States)

    Fujino, Hiroko; Itoda, Shoko; Sako, Saori; Matsuo, Kazuki; Sakamoto, Eiji; Yokoyama, Takeshi

    2013-02-01

    Hyperglycemia due to increase in insulin resistance (IR) is often observed after surgery in spite of normal insulin secretion. To evaluate the degree of IR, the golden standard method is the normoglycemic hyperinsulinemic clamp technique (glucose clamp: GC). The GC using the artificial pancreas, STG-22 (Nikkiso, Tokyo, Japan), was established as a more reliable method, since it was evaluated during steady-state period under constant insulin infusion. Homeostasis model assessment insulin resistance (HOMA-IR), however, is frequently employed in daily practice because of its convenience. We, therefore, investigated the reliability of HOMA-IR in comparison with the glucose clamp using the STG-22. Eight healthy patients undergoing maxillofacial surgery were employed in this study after obtaining written informed consent. Their insulin resistance was evaluated by HOMA-IR and the GC using the STG-22 before and after surgery. HOMA-IR increased from 0.81 +/- 0.48 to 1.17 +/- 0.50, although there were no significant differences between before and after surgery. On the other hand, M-value by GC significantly decreased after surgery from 8.82 +/- 2.49 mg x kg(-1) x min(-1) to 3.84 +/- 0.79 mg x kg(-1) x min(-1) (P = 0.0003). In addition, no significant correlation was found between the values of HOMA-IR and the M-value by GC. HOMA-IR may not be reliable to evaluate IR for perioperative period.

  6. Predicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IR.

    Science.gov (United States)

    Alptekin, Hüsnü; Çizmecioğlu, Ahmet; Işık, Hatice; Cengiz, Türkan; Yildiz, Murat; Iyisoy, Mehmet Sinan

    2016-05-01

    To determine the predictability of gestational diabetes mellitus (GDM) during the first trimester using the degree of insulin resistance and anthropometric measurements and to assign the risk of developing GDM by weight gained during pregnancy (WGDP). A total of 250 singleton pregnancies at 7-12 gestational weeks were studied. Body mass index (BMI), waist/hip ratio (WHR), quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR) scores and WGDP were determined. The backward stepwise method was applied to estimate possible associations with GDM. Cutoff points were estimated using receiver operating characteristic curve analysis. GDM was found in 20 of 227 singleton pregnancies (8.8 %). The calculated HOMA-IR, QUICKI, BMI, WHR, WGDP, and parity were significantly associated with GDM. Logistic regression analyses showed that three covariates (HOMA-IR, BMI, WGDP) remained independently associated with GDM. It was calculated as OR 1.254 (95 % CI 1.006-1.563), AUC 0.809, sensitivity 90 %, specificity 61 % with cutoff = 2.08 for HOMA-IR; OR 1.157 (CI 1.045-1.281), AUC 0.723, sensitivity 80 %, specificity 58 % with cutoff = 25.95 for BMI; OR 1.221, (CI 1.085-1.374), AUC 0.654, sensitivity 80 %, specificity 46 % with cutoff = 4.7 for WGDP. Despite a HOMA-IR score of >3.1 in pregnant women, GDM was detected in only three of 29 patients (10.3 %) if WGDP was HOMA-IR. In particular, if BMI is >25.95 kg/m(2) and the HOMA-IR score >2.08, controlling weight gain may protect against GDM.

  7. Genetics of variation in HOMA-IR and cardiovascular risk factors in Mexican-Americans.

    Science.gov (United States)

    Voruganti, V Saroja; Lopez-Alvarenga, Juan C; Nath, Subrata D; Rainwater, David L; Bauer, Richard; Cole, Shelley A; Maccluer, Jean W; Blangero, John; Comuzzie, Anthony G

    2008-03-01

    Insulin resistance is a major biochemical defect underlying the pathogenesis of cardiovascular disease (CVD). Mexican-Americans are known to have an unfavorable cardiovascular profile. Thus, the aim of this study was to investigate the genetic effect on variation in HOMA-IR and to evaluate its genetic correlations with other phenotypes related to risk of CVD in Mexican-Americans. The homeostatic model assessment method (HOMA-IR) is one of several approaches that are used to measure insulin resistance and was used here to generate a quantitative phenotype for genetic analysis. For 644 adults who had participated in the San Antonio Family Heart Study (SAFHS), estimates of genetic contribution were computed using a variance components method implemented in SOLAR. Traits that exhibited significant heritabilities were body mass index (BMI) (h (2) = 0.43), waist circumference (h (2) = 0.48), systolic blood pressure (h (2) = 0.30), diastolic blood pressure (h (2) = 0.21), pulse pressure (h (2) = 0.32), triglycerides (h (2) = 0.51), LDL cholesterol (h (2) = 0.31), HDL cholesterol (h (2) = 0.24), C-reactive protein (h (2) = 0.17), and HOMA-IR (h (2) = 0.33). A genome-wide scan for HOMA-IR revealed significant evidence of linkage on chromosome 12q24 (close to PAH (phenylalanine hydroxylase), LOD = 3.01, p HOMA-IR with BMI (rho (G) = 0.36), waist circumference (rho (G) = 0.47), pulse pressure (rho (G) = 0.39), and HDL cholesterol (rho (G) = -0.18). Identification of significant linkage for HOMA-IR on chromosome 12q replicates previous family-based studies reporting linkage of phenotypes associated with type 2 diabetes in the same chromosomal region. Significant genetic correlations between HOMA-IR and phenotypes related to CVD risk factors suggest that a common set of gene(s) influence the regulation of these phenotypes.

  8. Correlation between PAI-1, leptin and ferritin with HOMA in HIV/AIDS patients.

    Science.gov (United States)

    Dragović, Gordana; Sumarac-Dumanovic, Mirjana; Khawla, Al Musalhi; Soldatović, Ivan; Andjić, Mladen; Jevtović, Djordje; Nair, Devaki

    2018-06-22

    Data about correlation of interleukins (IL-1 α, IL-1 β, IFN γ, IL-2, IL-4, IL-6, IL-8, IL-10), adipocytokines (leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor alpha (TNFα), ferritin, C reactive protein (CRP) and vascular endothelial growth factor (VEGF) with homeostasis model assessment (HOMA) in HIV/AIDS patients are still limited. Therefore the aim of this study was to evaluate the possible correlations of serum levels of PAI-1, leptin and ferritin with HOMA in HIV/AIDS patients treated with combined antiretroviral therapy (cART). This cross-sectional study included 64 HIV/AIDS patients, all Caucasians, receiving cART at the HIV/AIDS Centre, Belgrade, Serbia. PAI-1, leptin, ferritin and insulin levels were measured using the Metabolic Syndrome Array I (Randox Laboratories Ltd., London, UK), while adiponectin and resistin levels were measured using Metabolic Syndrome Array II (Randox Laboratories Ltd., London, UK), interleukins (IL-1 α, IL-1 β, IFN γ, IL-2, IL-4, IL-6, IL-8, IL-10), MCP-1, TNF-α as well as VEGF was measured using Cytokine Array I (Randox Laboratories Ltd., London, UK). Insulin resistance was determined using the homeostasis model assessment index (HOMA). Multicollinearity of independent variables in multivariate model was analyzed using Variance Inflation Factor. Correlation analysis revealed significant correlations between HOMA and waist circumference, body mass index, patients' age, number of cART combinations and triglycerides (p = 0.001, p = 0.001, p = 0.050, p = 0.044, p = 0.002, respectively). HOMA negatively correlated with levels of high density lipoprotein (HDL) (Rho = -0.282; p = 0.025). PAI-1 (Rho = 0.334; p = 0.007) and leptin (Rho = 0.492; p = 0.001) together with ferritin (Rho = 0.396, p = 0.001) positively and significantly correlated with HOMA. Levels of IL-1 α, IL-1 β, IFN

  9. Prospectiva, fundamentos y un caso práctico

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    Franklin Serrano

    1994-05-01

    Full Text Available RESUMEN La aparición de la informática y su alto desarrollo alcanzado, ha generado  un movimiento modernizador de las empresas, tendiente especialmente a lograr sobrevivir  y proponerse  a tono con las nuevas   tendencias competitiva. La utilización de las nuevas tecnologías, nuevas formas de planear  y nuevas formas de gerenciar. Estos cambios se imponen como resultados  de las actuales tendencias mundiales del mercado, los nuevos conocimientos y el cambio en la forma de estructurar el pensamiento. El hombre hace tiempo aceptó la teoría de que el mismo forja su propio destino, y es así como ha recurrido constantemente a la utilización y creación de técnicas que facilitan la proyección de un futuro acorde con sus deseos. El presente escrito tiene por objeto, exponer los elementos básicos de los Fundamentos y las técnicas de escenarios para el manejo de la Prospectiva. Como experiencia práctica se presenta un estudio de caso sencillo utilizando Software desarrollado por los autores.

  10. Relation with HOMA-IR and thyroid hormones in obese Turkish women with metabolic syndrome.

    Science.gov (United States)

    Topsakal, S; Yerlikaya, E; Akin, F; Kaptanoglu, B; Erürker, T

    2012-03-01

    The aim of this study was to investigate the relationship between insulin resistance and thyroid function in obese pre- and postmenopausal women with or without metabolic syndrome (MetS). 141 obese women were divided into two groups, HOMA-IRHOMA-IR>2.7, to evaluate relation with HOMA-IR and fatness, hormone and blood parameters. They were then divided into four groups as pre- and postmenopausal with or without MetS. Various fatness, hormone and blood parameters were examined. Statistically significant difference was found in weight, body mass index (BMI), waist circumference, fat%, fasting insulin, TSH, FT3, FT4, FSH, Anti-microsomal antibody (ANTIM) and triglycerides levels in HOMA-IRHOMA-IR>2.7 obese Turkish women. This study showed that age, weight, BMI, waist circumference, fat%, fasting insulin, FT3, ANTIM, FSH, LH, total cholesterol, triglycerides, HDL, HOMA-IR, systolic and diastolic blood pressure levels were related in preand post menopausal status in obese women with or without MetS. Obesity may influence the levels of thyroid hormones and increases the risk of MetS in women. Postmenopausal status with MetS is associated with an increased TSH, FT3 and FT4 levels and HOMA-IR in obese women. Strong relation was observed with MetS and TSH and FT3 levels.

  11. The correlation between serum AMH and HOMA-IR among PCOS phenotypes.

    Science.gov (United States)

    Wiweko, Budi; Indra, Indra; Susanto, Cynthia; Natadisastra, Muharam; Hestiantoro, Andon

    2018-02-09

    Polycystic ovarian syndrome (PCOS) is known to be one of the most prevalent endocrine disorders affecting reproductive age women. One of the endocrine disorder is hyperinsulinemia, which corresponds with the severity of PCOS. However, the pathogenesis of PCOS is not fully understood, but one theory of anti-mullerian hormone (AMH) has been proposed as one of the factor related to the degree of severity of PCOS. However, there are no clear correlation between levels of AMH with the incidence of insulin resistance in PCOS patients especially in Indonesia. This is a cross-sectional study involving reproductive age women aged 18-35 years. Subjects were recruited consecutively at Dr. Cipto Mangunkusumo General Hospital between 2011 until 2014. PCOS women diagnosed using 2003 Rotterdam criteria were categorized into four different PCOS phenotypes. Subsequently, serum level of AMH and HOMA-IR was measured and evaluated with correlation tests performed using SPSS 11.0 RESULTS: A total of 125 PCOS patients were included in a study conducted within a 3-year period. Phenotype 1 (anovulation, hyperandrogenism, and polycystic ovaries) shows the highest levels of AMH and HOMA-IR, which decreases in accordance to severity level (p HOMA-IR persisted even after adjusting for BMI in multivariate analysis. There was a positive correlation between serum AMH and HOMA IR levels. Serum AMH and HOMA IR levels were significantly different across the four PCOS phenotypes; with the highest values were present with phenotype 1.

  12. Identifying metabolic syndrome in African American children using fasting HOMA-IR in place of glucose.

    Science.gov (United States)

    Sharma, Sushma; Lustig, Robert H; Fleming, Sharon E

    2011-05-01

    Metabolic syndrome (MetS) is increasing among young people. We compared the use of homeostasis model assessment of insulin resistance (HOMA-IR) with the use of fasting blood glucose to identify MetS in African American children. We performed a cross-sectional analysis of data from a sample of 105 children (45 boys, 60 girls) aged 9 to 13 years with body mass indexes at or above the 85th percentile for age and sex. Waist circumference, blood pressure, and fasting levels of blood glucose, insulin, triglycerides, and high-density lipoprotein cholesterol were measured. We found that HOMA-IR is a stronger indicator of MetS in children than blood glucose. Using HOMA-IR as 1 of the 5 components, we found a 38% prevalence of MetS in this sample of African American children and the proportion of false negatives decreased from 94% with blood glucose alone to 13% with HOMA-IR. The prevalence of MetS was higher in obese than overweight children and higher among girls than boys. Using HOMA-IR was preferred to fasting blood glucose because insulin resistance was more significantly interrelated with the other 4 MetS components.

  13. New measure of insulin sensitivity predicts cardiovascular disease better than HOMA estimated insulin resistance.

    Science.gov (United States)

    Venkataraman, Kavita; Khoo, Chin Meng; Leow, Melvin K S; Khoo, Eric Y H; Isaac, Anburaj V; Zagorodnov, Vitali; Sadananthan, Suresh A; Velan, Sendhil S; Chong, Yap Seng; Gluckman, Peter; Lee, Jeannette; Salim, Agus; Tai, E Shyong; Lee, Yung Seng

    2013-01-01

    Accurate assessment of insulin sensitivity may better identify individuals at increased risk of cardio-metabolic diseases. To examine whether a combination of anthropometric, biochemical and imaging measures can better estimate insulin sensitivity index (ISI) and provide improved prediction of cardio-metabolic risk, in comparison to HOMA-IR. Healthy male volunteers (96 Chinese, 80 Malay, 77 Indian), 21 to 40 years, body mass index 18-30 kg/m(2). Predicted ISI (ISI-cal) was generated using 45 randomly selected Chinese through stepwise multiple linear regression, and validated in the rest using non-parametric correlation (Kendall's tau τ). In an independent longitudinal cohort, ISI-cal and HOMA-IR were compared for prediction of diabetes and cardiovascular disease (CVD), using ROC curves. The study was conducted in a university academic medical centre. ISI measured by hyperinsulinemic euglycemic glucose clamp, along with anthropometric measurements, biochemical assessment and imaging; incident diabetes and CVD. A combination of fasting insulin, serum triglycerides and waist-to-hip ratio (WHR) provided the best estimate of clamp-derived ISI (adjusted R(2) 0.58 versus 0.32 HOMA-IR). In an independent cohort, ROC areas under the curve were 0.77±0.02 ISI-cal versus 0.76±0.02 HOMA-IR (p>0.05) for incident diabetes, and 0.74±0.03 ISI-cal versus 0.61±0.03 HOMA-IR (pHOMA-IR. This may be useful for estimating insulin sensitivity and cardio-metabolic risk in clinical and epidemiological settings.

  14. The Effect of Pumpkin on GLP-1 and HOMA-β in Hypercholesterolemic Rats

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    Sunarti

    2016-03-01

    Full Text Available Background and aim: High fat and fructose diet may impair β cell function through oxidative stress that is induced by subsequent hypercholesterolemia. The β cell function is usually quantified by homeostatic model assessment beta-cell function (HOMA-β. Oxidative stress may be decreased by β-carotene from pumpkin (Cucurbita maxima. This study aimed to evaluate the effects of pumpkin powder on glucagon-like peptide-1 (GLP-1 level and HOMA-β in rats with high fat and fructose diet.

  15. Reference ranges of HOMA-IR in normal-weight and obese young Caucasians.

    Science.gov (United States)

    Shashaj, Blegina; Luciano, Rosa; Contoli, Benedetta; Morino, Giuseppe Stefano; Spreghini, Maria Rita; Rustico, Carmela; Sforza, Rita Wietrzycowska; Dallapiccola, Bruno; Manco, Melania

    2016-04-01

    Insulin resistance (IR) may develop very early in life being associated with occurrence of cardiometabolic risk factors (CMRFs). Aim of the present study was to identify in young Caucasians normative values of IR as estimated by the homeostasis model assessment (HOMA-IR) and cutoffs diagnostic of CMRFs. Anthropometrics and biochemical parameters were assessed in 2753 Caucasians (age 2-17.8 years; 1204 F). Reference ranges of HOMA-IR were defined for the whole population and for samples of normal-weight and overweight/obese individuals. The receiver operator characteristic analysis was used to find cutoffs of HOMA-IR accurately identifying individuals with any CMRF among total cholesterol and/or triglycerides higher than the 95th percentile and/or HDL cholesterol lower than the 5th for age and sex, impaired glucose tolerance, and alanine aminotransferase levels ≥40 U/l. Overweight/obese individuals had higher HOMA-IR levels compared with normal-weight peers (p HOMA-IR index rose progressively with age, plateaued between age 13 and 15 years and started decreasing afterward. HOMA-IR peaked at age 13 years in girls and at 15 years in boys. The 75th percentile of HOMA-IR in the whole population (3.02; AUROC = 0.73, 95 % CI = 0.70-0.75), in normal-weight (1.68; AUROC = 0.76, 95 % CI = 0.74-0.79), and obese (3.42; AUROC = 0.71, 95 % CI = 0.69-0.72) individuals identified the cutoffs best classifying individuals with any CMRF. Percentiles of HOMA-IR varied significantly in young Caucasians depending on sex, age, and BMI category. The 75th percentile may represent an accurate cutoff point to suspect the occurrence of one or more CMRFs among high total cholesterol and triglycerides, low HDL cholesterol, and ALT ≥ 40 UI/l.

  16. Homa1-ir And Homa2-ir Indexes In Identifying Insulin Resistance And Metabolic Syndrome - Brazilian Metabolic Syndrome Study (brams) [Índices Homa1-ir E Homa2-ir Para Identificação De Resistência à Insulina E Síndrome Metabólica - Estudo Brasileiro De Síndrome Metabólica (brams)

    OpenAIRE

    Geloneze B.; Vasques A.C.J.; Stabe C.F.C.; Pareja J.C.; de Lima Rosado L.E.F.P.; de Queiroz E.C.; Tambascia M.A.

    2009-01-01

    Objective: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Methods: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. Results: In the he...

  17. Food security in HIV/AIDS response: Insights from Homa Bay, Kenya ...

    African Journals Online (AJOL)

    This paper examines the viability and effectiveness of a pilot farming initiative in reversing impacts of HIV/AIDS on the most affected households in Homa Bay, Kenya. The paper argues that once patients are stable, they can effectively be engaged in farming with minimal financial and technical support, resulting in enhanced ...

  18. [Distribution of HOMA-IR among children and adolescent in Zhangzhou and Zhongshan cities].

    Science.gov (United States)

    He, Jinshui; Lin, Guomo; Zhang, Yugui; Ye, Xiaoling; Liu, Fuxing; Liu, Linyong

    2015-07-01

    To investigate the distribution of the homeostasis model assessment of insulin resistance (HOMA-IR) among children and adolescent in Zhangzhou city and Zhongshan city. Total of 3102 children and adolescent aged 6 to 18-year-old were recruited, which were enrolled in a population-based cross-sectional study. Anthropometric and biochemical parameters were measured. A total of 1528 (49.26%) girls and 1574 (50.74%) boys were included in this study. The concentrations of insulin and fasting glucose gradually increased from 6 to 18 years of age, there was no statistical difference between boys ang girls. The mean values for the BMI were similar in age-matched boys and girls from 6 to 18-year-old ,but for 12 to 15-year-old children was significantly higher in the girls compared with the boys and conversely for 16 to 18-year-old (P HOMA-IR gradually increased with age and reached a plateau at 12 years of age and there was no markedly differential in gender. The glucose levels, insulin concentrations and HOMA-IR exhibited a gradual increase with age. It was suggested that the evaluation of IR in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point.

  19. A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men.

    Science.gov (United States)

    Park, Sung Keun; Chun, Hyejin; Ryoo, Jae-Hong; Lee, Sang Wha; Lee, Hong Soo; Shim, Kyung Won; Cho, Choo Yon; Ryu, Dong-Ryeol; Ko, Taeg Su; Kim, Eugene; Park, Se-Jin; Park, Jai Hyung; Hong, Seok Jin; Hong, Hyun Pyo

    2015-06-15

    Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, PHOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (P for linear trend=0.054). Increased insulin resistance was a predictor of microalbuminuria in Korean men. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Five-membered heterocycles. Part II. Crystal structures and HOMA index calculations for selected 1,3,4-thiadiazole derivatives

    Science.gov (United States)

    Mrozek, A.; Karolak-Wojciechowska, J.; Amiel, P.; Barbe, J.

    2000-06-01

    Crystal structures of four bisubstituted 1,3,4-thiadiazole derivatives were determined. Detailed description of the five-membered heteroring geometry is enabled thorough analysis of ring aromaticity. For this purpose the HOMA index was used as a quantitative measure of aromaticity. The calculated HOMA indices evidenced the role of substituents. In particular, increase in the substituent electrophilicity brings about increase in aromaticity.

  1. Pengaruh pemberian ekstrak kedelai hitam (Glycine soja. berbagai dosis terhadap kadar glukosa darah, kadar insulin, dan HOMA-IR

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    Dewi M Kurniawati

    2017-12-01

    Conclusion: There are differences on insulin levels and HOMA – IR in 500 and 750 mg/kgBW dosages groups. However, there is no difference on blood glucose before and after black soybean extract treatment. The most decreased levels of blood glucose, insulin and HOMA- IR were in 750mg/kgBW dosage.

  2. Serum Interleukin-6, insulin, and HOMA-IR in male individuals with colorectal adenoma.

    Science.gov (United States)

    Sasaki, Yu; Takeda, Hiroaki; Sato, Takeshi; Orii, Tomohiko; Nishise, Shoichi; Nagino, Ko; Iwano, Daisuke; Yaoita, Takao; Yoshizawa, Kazuya; Saito, Hideki; Tanaka, Yasuhisa; Kawata, Sumio

    2012-01-15

    It is widely acknowledged that chronic low-grade inflammation plays a key role in the development of obesity-related insulin resistance and type 2 diabetes. The level of circulating interleukin-6 (IL-6), one of the major proinflammatory adipokines, is correlated with obesity and insulin resistance, which are known to be risk factors for colorectal adenoma. We examined the association between the circulating level of IL-6 and the presence of colorectal adenoma. In a total colonoscopy-based cross-sectional study conducted between January and December 2008, serum levels of IL-6 were measured in samples of venous blood obtained from 336 male participants attending health checkups (118 individuals with colorectal adenoma and 218 age-matched controls) after an overnight fast. In the colorectal adenoma group, the median levels of serum IL-6 (1.24 vs. 1.04 pg/mL; P = 0.01), triglyceride, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were to be significantly higher than those in the control group. When restricted to individuals with adenoma, levels of IL-6 were positively correlated with body mass index, insulin, and HOMA-IR. Multiple logistic analyses adjusted to include insulin or HOMA-IR showed that high levels of IL-6 were associated with the presence of colorectal adenoma. There was no significant interaction of IL-6 with HOMA-IR to modify this association. Our findings suggest that increased serum levels of IL-6 are positively associated with the presence of colorectal adenoma in men, independently of insulin and HOMA-IR. ©2011 AACR.

  3. High HOMA-IR, adjusted for puberty, relates to the metabolic syndrome in overweight and obese Chilean youths.

    Science.gov (United States)

    Burrows, Raquel A; Leiva, Laura B; Weisstaub, Gerardo; Lera, Lydia M; Albala, Cecilia B; Blanco, Estela; Gahagan, Sheila

    2011-05-01

    To determine how the homeostasis model assessment of insulin resistance (HOMA-IR) is related to metabolic risk in a sample of overweight and obese Chilean youths accounting for Tanner stage. A cross-sectional study assessing 486 overweight and obese youths (aged 5-15 years) recruited from the University of Chile, Pediatric Obesity Clinic. We measured anthropometry, Tanner stage, HOMA-IR, and laboratory tests related to metabolic risk. HOMA-IR was categorized by quartile for children (Tanner stages I and II) and adolescents (Tanner stage III and above) from a normative Chilean sample. Children and adolescents with HOMA-IR in the highest quartile were likely to have higher body mass index (BMI) Z-scores, elevated waist circumference, systolic and diastolic blood pressure, and triglycerides and low high-density lipoprotein. HOMA-IR had good negative predictive value for characteristics of the metabolic syndrome (MetS; 0.82). In a multivariate regression model, BMI Z-score [odds ratio (OR) 1.5] and HOMA-IR (OR 3.3) predicted 22% of the variance for the MetS, with 36% of the explained variance attributed to HOMA-IR. In a large clinical sample of overweight and obese Chilean youths, HOMA-IR ≥ 75th percentile was significantly associated with the cluster of factors referred to as the MetS. We emphasize the importance of establishing percentiles for HOMA-IR based on a normative sample and taking Tanner stage into account. Although BMI is easy to assess and interpret with minimal costs in a clinical setting, adding HOMA-IR explains more of the variance in the MetS than BMI Z-score alone. © 2011 John Wiley & Sons A/S.

  4. The Homeostasis Model Assessment-adiponectin (HOMA-AD) is the most sensitive predictor of insulin resistance in obese children.

    Science.gov (United States)

    Makni, Emna; Moalla, Wassim; Lac, Gérard; Aouichaoui, Chirine; Cannon, Daniel; Elloumi, Mohamed; Tabka, Zouhair

    2012-02-01

    The aim of this study was to examine the efficacy of three indices i.e. adiponectin/leptin ratio, HOMA-IR and HOMA-AD in assessing insulin resistance among obese children. One hundred and twenty-two obese children (57 girls, 65 boys): mean age 13.7±1.3 years, BMI 30.1±4.5kg/m(2), eight tanner stage I, 48 tanner stage II-III, 66 tanner stage IV-V, participated in this study. They were classified into four groups according to sex and the presence of metabolic syndrome characteristics: with metabolic syndrome (MS; 21 girls and 36 boys) and controls without metabolic syndrome (CON, 36 girls and 29 boys). The correlations between these three indices of insulin resistance and the MS criteria were analyzed using linear and multiple regressions and receiver operating characteristics (ROC) curves analysis. The majority of anthropometric and biological parameters as well as adiponectin/leptin ratio, HOMA-IR and HOMA-AD were significantly different between MS and CON in both sexes. Both HOMA-AD and HOMA-IR were significantly correlated with the majority of metabolic syndrome components than was the adiponectin/leptin ratio in MS of both sexes. In boys and girls with and without MS, multiple regression analyses highlighted that both HOMA-AD and adiponectin/leptin ratio (r=-0.99 and r=-0.54 for MS girls and boys respectively, 0.05HOMA-AD and HOMA-IR (r=0.66 and r=0.31 for MS girls and boys respectively, 0.05HOMA-IR. Additionally, the area under the ROC curves for predicting insulin resistance were 0.69 (CI 95%, 0.60-0.77), 0.68 (CI 95%, 0.59-0.76) and 0.71 (CI 95%, 0.62-0.79) for adiponectin/leptin ratio, HOMA-IR and HOMA-AD, respectively. The current study strengthens the validity of the HOMA-AD as an adequate tool for determining insulin resistance among obese children with MS. Copyright © 2012. Published by Elsevier Masson SAS.

  5. Birth-weight, insulin levels, and HOMA-IR in newborns at term

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    Simental-Mendía Luis E

    2012-07-01

    Full Text Available Abstract Background Recent studies have demonstrated that low and high birth-weight at birth are risk factors of developing diabetes. The aim of this study was to determine if the abnormal birth-weight is related with hyperinsulinemia and elevated index of the Homeostasis Model assessment for Insulin Resistance (HOMA-IR at birth, in at term newborns. Methods Newborns with gestational age between 38 and 41 weeks, products of normal pregnancies of healthy mothers aged 18 to 39 years, were eligible to participate. Small-for-gestational age (SGA and large-for-gestational age (LGA newborns were compared with appropriate-for-gestational (AGA age newborns. Incomplete or unclear data about mother’s health status, diabetes, gestational diabetes, history of gestational diabetes, hypertension, pre-eclampsia, eclampsia, and other conditions that affect glucose metabolism were exclusion criteria. Hyperinsulinemia was defined by serum insulin levels ≥13.0 μU/mL and IR by HOMA-IR ≥2.60. Multiple logistic regression analysis was used to determine the odds ratio (OR that computes the association between birth-weight (independent variable with hyperinsulinemia and HOMA-IR index (dependent variables. Results A total of 107 newborns were enrolled; 13, 22, and 72 with SGA, LGA, and AGA, respectively. Hyperinsulinemia was identified in 2 (15.4%, 6 (27.3%, and 5 (6.9% with SGA, LGA, and AGA (p=0.03, whereas IR in 3 (23.1%, 8 (36.4%, and 10 (13.9% newborns with SGA, LGA and AGA (p=0.06. The LGA showed a strong association with hyperinsulinemia (OR 5.02; CI 95%, 1.15-22.3; p=0.01 and HOMA-IR (OR 3.54; CI 95%, 1.03-12.16; p=0.02; although without statistical significance, the SGA showed a tendency of association with hyperinsulinemia (OR 2.43; CI 95%, 0.43-17.3 p=0.29 and HOMA-IR (OR 1.86; CI 95%, 0.33-9.37; p=0.41. Conclusions Our results suggest that LGA is associated with hyperinsulinemia and elevated HOMA-IR at birth whereas the SGA show a tendency of

  6. Birth-weight, insulin levels, and HOMA-IR in newborns at term.

    Science.gov (United States)

    Simental-Mendía, Luis E; Castañeda-Chacón, Argelia; Rodríguez-Morán, Martha; Guerrero-Romero, Fernando

    2012-07-07

    Recent studies have demonstrated that low and high birth-weight at birth are risk factors of developing diabetes. The aim of this study was to determine if the abnormal birth-weight is related with hyperinsulinemia and elevated index of the Homeostasis Model assessment for Insulin Resistance (HOMA-IR) at birth, in at term newborns. Newborns with gestational age between 38 and 41 weeks, products of normal pregnancies of healthy mothers aged 18 to 39 years, were eligible to participate. Small-for-gestational age (SGA) and large-for-gestational age (LGA) newborns were compared with appropriate-for-gestational (AGA) age newborns. Incomplete or unclear data about mother's health status, diabetes, gestational diabetes, history of gestational diabetes, hypertension, pre-eclampsia, eclampsia, and other conditions that affect glucose metabolism were exclusion criteria. Hyperinsulinemia was defined by serum insulin levels ≥13.0 μU/mL and IR by HOMA-IR ≥2.60. Multiple logistic regression analysis was used to determine the odds ratio (OR) that computes the association between birth-weight (independent variable) with hyperinsulinemia and HOMA-IR index (dependent variables). A total of 107 newborns were enrolled; 13, 22, and 72 with SGA, LGA, and AGA, respectively. Hyperinsulinemia was identified in 2 (15.4%), 6 (27.3%), and 5 (6.9%) with SGA, LGA, and AGA (p=0.03), whereas IR in 3 (23.1%), 8 (36.4%), and 10 (13.9%) newborns with SGA, LGA and AGA (p=0.06). The LGA showed a strong association with hyperinsulinemia (OR 5.02; CI 95%, 1.15-22.3; p=0.01) and HOMA-IR (OR 3.54; CI 95%, 1.03-12.16; p=0.02); although without statistical significance, the SGA showed a tendency of association with hyperinsulinemia (OR 2.43; CI 95%, 0.43-17.3 p=0.29) and HOMA-IR (OR 1.86; CI 95%, 0.33-9.37; p=0.41). Our results suggest that LGA is associated with hyperinsulinemia and elevated HOMA-IR at birth whereas the SGA show a tendency of association.

  7. New measure of insulin sensitivity predicts cardiovascular disease better than HOMA estimated insulin resistance.

    Directory of Open Access Journals (Sweden)

    Kavita Venkataraman

    Full Text Available CONTEXT: Accurate assessment of insulin sensitivity may better identify individuals at increased risk of cardio-metabolic diseases. OBJECTIVES: To examine whether a combination of anthropometric, biochemical and imaging measures can better estimate insulin sensitivity index (ISI and provide improved prediction of cardio-metabolic risk, in comparison to HOMA-IR. DESIGN AND PARTICIPANTS: Healthy male volunteers (96 Chinese, 80 Malay, 77 Indian, 21 to 40 years, body mass index 18-30 kg/m(2. Predicted ISI (ISI-cal was generated using 45 randomly selected Chinese through stepwise multiple linear regression, and validated in the rest using non-parametric correlation (Kendall's tau τ. In an independent longitudinal cohort, ISI-cal and HOMA-IR were compared for prediction of diabetes and cardiovascular disease (CVD, using ROC curves. SETTING: The study was conducted in a university academic medical centre. OUTCOME MEASURES: ISI measured by hyperinsulinemic euglycemic glucose clamp, along with anthropometric measurements, biochemical assessment and imaging; incident diabetes and CVD. RESULTS: A combination of fasting insulin, serum triglycerides and waist-to-hip ratio (WHR provided the best estimate of clamp-derived ISI (adjusted R(2 0.58 versus 0.32 HOMA-IR. In an independent cohort, ROC areas under the curve were 0.77±0.02 ISI-cal versus 0.76±0.02 HOMA-IR (p>0.05 for incident diabetes, and 0.74±0.03 ISI-cal versus 0.61±0.03 HOMA-IR (p<0.001 for incident CVD. ISI-cal also had greater sensitivity than defined metabolic syndrome in predicting CVD, with a four-fold increase in the risk of CVD independent of metabolic syndrome. CONCLUSIONS: Triglycerides and WHR, combined with fasting insulin levels, provide a better estimate of current insulin resistance state and improved identification of individuals with future risk of CVD, compared to HOMA-IR. This may be useful for estimating insulin sensitivity and cardio-metabolic risk in clinical and

  8. Revisión de los fundamentos teóricos de la gimnasia abdominal hipopresiva

    OpenAIRE

    Cabañas Armesilla, Maria Dolores

    2014-01-01

    La gimnasia abdominal hipopresiva (GAH) es un sistema de tonificación de la musculatura abdominal, del suelo pélvico y de los estabilizadores de la columna. Como característica diferenciadora se alega que estos ejercicios no provocan aumento de la presión abdominal. El objetivo es evaluar la validez de los fundamentos teóricos de la GAH y fundamentar su práctica. Para ello se ha realizado una revisión bibliográfica. Se han encontrado discrepancias entre los fundamentos teóricos de la ...

  9. HOMA-IR and the risk of hyperuricemia: a prospective study in non-diabetic Japanese men.

    Science.gov (United States)

    Nakamura, Koshi; Sakurai, Masaru; Miura, Katsuyuki; Morikawa, Yuko; Nagasawa, Shin-Ya; Ishizaki, Masao; Kido, Teruhiko; Naruse, Yuchi; Nakashima, Motoko; Nogawa, Kazuhiro; Suwazono, Yasushi; Nakagawa, Hideaki

    2014-10-01

    To examine the relation of insulin resistant status determined by homeostasis model assessment of insulin resistance (HOMA-IR) with the risk of incident hyperuricemia. The study participants included 2071 Japanese men without hyperuricemia and diabetes, aged 35-54 years. The participants had undergone annual heath examinations for 6 years to compare incident hyperuricemia (serum uric acid >416.4μmol/L (7.0mg/dL) and/or taking medication for hyperuricemia) in four groups based on quartiles of baseline HOMA-IR. During follow-up there were 331 incident cases of hyperuricemia. The hazard ratios for hyperuricemia, compared with HOMA-IR ≤0.66, were 1.42 (95% confidence interval 1.02-1.98) for HOMA-IR 0.67-0.98, 1.20 (0.86-1.68) for HOMA-IR 0.99-1.49 and 1.44 (1.04-1.98) for HOMA-IR ≥1.50 after adjustment for baseline serum uric acid, creatinine, hypercholesterolemia and hypertension status, age, alcohol intake, and smoking and exercise habits. The hazard ratio associated with an increase of one standard deviation in lnHOMA-IR (1.85 as one geometric standard deviation of HOMA-IR) was 1.14 (1.03-1.28) (p for trend=0.02). Increased HOMA-IR independently predicted the subsequent development of hyperuricemia. Insulin resistance itself or compensatory hyperinsulinemia may contribute to the development of hyperuricemia. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  10. HOMA-IR and QUICKI: decide on a general standard instead of making further comparisons.

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    Rössner, Sophia M; Neovius, Martin; Mattsson, Anna; Marcus, Claude; Norgren, Svante

    2010-11-01

    To limit further comparisons between the two fasting indices Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI), and to examine their robustness in assessing insulin sensitivity. A total of 191 obese children and adolescents (age 13.9 ± 2.9 years, BMI SDS 6.1 ± 1.6), who had undergone a Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT), were included. Receiver operating characteristic curve (ROC) analysis was used to compare indices in detecting insulin resistance and Bland-Altman plots to investigate agreement between three consecutive fasting samples when compared to using single samples. ROC analysis showed that the diagnostic accuracy was identical for QUICKI and HOMA-IR [area under the curve (AUC) boys 0.80, 95%CI 0.70-0.89; girls 0.80, 0.71-0.88], while insulin had a nonsignificantly lower AUC (boys 0.76, 0.66-0.87; girls 0.75, 0.66-0.84). Glucose did not perform better than chance as a diagnostic test (boys 0.47, 0.34-0.60; girls 0.57, 0.46-0.68). Indices varied with consecutive sampling, mainly attributable to fasting insulin variations (mean maximum difference in HOMA-IR -0.8; -0.9 to -0.7). Using both HOMA-IR and QUICKI in further studies is superfluous as these indices function equally well as predictors of the FSIVGTT sensitivity index. Focus should be on establishing a general standard for research and clinical purposes. © 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica.

  11. Ancestral effect on HOMA-IR levels quantitated in an American population of Mexican origin.

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    Qu, Hui-Qi; Li, Quan; Lu, Yang; Hanis, Craig L; Fisher-Hoch, Susan P; McCormick, Joseph B

    2012-12-01

    An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR. We performed ancestral analysis in 1,551 participants of the Cameron County Hispanic Cohort by genotyping 103 ancestry-informative markers (AIMs). These AIMs allow determination of the percentage (0-100%) ancestry from three major continental populations, i.e., European, African, and Amerindian. We observed that predominantly Amerindian ancestral components were associated with increased HOMA-IR (β = 0.124, P = 1.64 × 10(-7)). The correlation was more significant in males (Amerindian β = 0.165, P = 5.08 × 10(-7)) than in females (Amerindian β = 0.079, P = 0.019). This unique study design demonstrates how genomic markers for quantitative ancestral information can be used in admixed populations to predict phenotypic traits such as insulin resistance.

  12. OGTT results in obese adolescents with normal HOMA-IR values.

    Science.gov (United States)

    Sahin, Nursel Muratoglu; Kinik, Sibel Tulgar; Tekindal, Mustafa Agah

    2013-01-01

    To investigate insulin resistance (IR) with OGTT in obese adolescents who have normal fasting insulin and homeostasis model assessment for insulin resistance (HOMA-IR). A total of 97 obese adolescents who had values of HOMA-IR IR using an insulin peak of ≥150 μU/mL (1041.8 pmol/L) and/or ≥75 μU/mL (520.9 pmol/L) 120 min after glucose charge and the sum of insulin levels >2083.5 pmol/L (300 μU/mL) in OGTT. IR risk factors were defined as family history of diabetes mellitus, acanthosis nigricans (AN), and hepatic steatosis. IR was detected in 61 (62.9%) patients. The IR group had significantly more frequent AN (p=0.0001). As the number of risk factors increased, the frequency of IR also increased (p=0.01). We advise to perform OGTT in obese adolescents with normal HOMA-IR, if they have risk factors for IR.

  13. Enseñanza Flexible y Aprendizaje Abierto, Fundamentos clave de los PLEs

    OpenAIRE

    Salinas Ibáñez, Jesús

    2013-01-01

    Para citar: Salinas, J. (2013). Enseñanza Flexible y Aprendizaje Abierto, Fundamentos clave de los PLEs. En L. Castañeda y J. Adell (Eds.), Entornos Personales de Aprendizaje: Claves para el ecosistema educativo en red (pp. 53-70). Alcoy: Marfil.

  14. Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

    OpenAIRE

    Isokuortti, Elina; Zhou, You; Peltonen, Markku; Bugianesi, Elisabetta; Clement, Karine; Bonnefont-Rousselot, Dominique; Lacorte, Jean-Marc; Gastaldelli, Amalia; Schuppan, Detlef; Schattenberg, Jörn M.; Hakkarainen, Antti; Lundbom, Nina; Jousilahti, Pekka; Männistö, Satu; Keinänen-Kiukaanniemi, Sirkka

    2017-01-01

    Aims/hypothesis\\ud \\ud Recent European guidelines for non-alcoholic fatty liver disease (NAFLD) call for reference values for HOMA-IR. In this study, we aimed to determine: (1) the upper limit of normal HOMA-IR in two population-based cohorts; (2) the HOMA-IR corresponding to NAFLD; (3) the effect of sex and PNPLA3 genotype at rs738409 on HOMA-IR; and (4) inter-laboratory variations in HOMA-IR.\\ud \\ud Methods\\ud \\ud We identified healthy individuals in two population-based cohorts (FINRISK 20...

  15. The definition of insulin resistance using HOMA-IR for Americans of Mexican descent using machine learning.

    Science.gov (United States)

    Qu, Hui-Qi; Li, Quan; Rentfro, Anne R; Fisher-Hoch, Susan P; McCormick, Joseph B

    2011-01-01

    The lack of standardized reference range for the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index has limited its clinical application. This study defines the reference range of HOMA-IR index in an adult Hispanic population based with machine learning methods. This study investigated a Hispanic population of 1854 adults, randomly selected on the basis of 2000 Census tract data in the city of Brownsville, Cameron County. Machine learning methods, support vector machine (SVM) and Bayesian Logistic Regression (BLR), were used to automatically identify measureable variables using standardized values that correlate with HOMA-IR; K-means clustering was then used to classify the individuals by insulin resistance. Our study showed that the best cutoff of HOMA-IR for identifying those with insulin resistance is 3.80. There are 39.1% individuals in this Hispanic population with HOMA-IR>3.80. Our results are dramatically different using the popular clinical cutoff of 2.60. The high sensitivity and specificity of HOMA-IR>3.80 for insulin resistance provide a critical fundamental for our further efforts to improve the public health of this Hispanic population.

  16. PEDIATRIC VISCERAL ADIPOSITY INDEX ADAPTATION CORRELATES WITH HOMA-IR, MATSUDA, AND TRANSAMINASES.

    Science.gov (United States)

    Hernández, María José Garcés; Klünder, Miguel; Nieto, Nayely Garibay; Alvarenga, Juan Carlos López; Gil, Jenny Vilchis; Huerta, Samuel Flores; Siccha, Rosa Quispe; Hernandez, Joselin

    2018-03-01

    Visceral adiposity index (VAI) is a mathematical model associated with cardiometabolic risk in adults, but studies on children failed to support this association. Our group has proposed a pediatric VAI model using pediatric ranges, but it has not yet been evaluated and needs further adjustments. The objective of this study was to further adjust the proposed pediatric VAI by age, creating a new pediatric metabolic index (PMI), and assess the correlation of the PMI with insulin resistance indexes and hepatic enzymes. A cross-sectional design with data from 396 children (age 5 to 17 years) was analyzed with a generalized linear model to find the coefficients for triglycerides, high-density-lipoprotein cholesterol, and waist circumference-body mass index quotient. The model was constructed according to sex and age and designated PMI. A cross-validation analysis was performed and a receiver operating characteristic curve was used to determine cut-off points. Significant moderate correlation was found between PMI and homeostatic model assessment of insulin resistance (HOMA-IR) ( r = 0.452; P = .003), Matsuda ( r = -0.366; P = .019), alanine aminotransferase ( r = 0.315, P = .045), and γ-glutamyltransferase ( r = 0.397; P = .010). A PMI score >1.7 was considered as risk. PMI correlates with HOMA-IR, Matsuda, and hepatic enzymes. It could be helpful for identifying children at risk for cardiometabolic diseases. ALT = alanine transaminase BMI = body mass index GGT = γ-glutamyltransferase HDL-C = high-density-lipoprotein cholesterol HOMA-IR = homeostatic model assessment of insulin resistance hs-CRP = high sensitivity C-reactive protein ISI = insulin sensitivity index NAFLD = nonalcoholic fatty liver disease PMI = pediatric metabolic index QUICKI = quantitative insulin sensitivity check index ROC = receiver operating characteristic TG = triglyceride TNF-α = tumor necrosis factor-alpha VAI = visceral adiposity index VAT = visceral adipose tissue WC = waist circumference.

  17. High-molecular weight adiponectin/HOMA-IR ratio as a biomarker of metabolic syndrome in urban multiethnic Brazilian subjects.

    Science.gov (United States)

    de Abreu, Virgínia Genelhu; Martins, Cyro José de Moraes; de Oliveira, Patricia Aguiar Cardoso; Francischetti, Emilio Antonio

    2017-01-01

    Metabolic syndrome (MetS) has an important epidemiological relevance due to its increasing prevalence and association with type 2 diabetes and cardiovascular disease. Insulin resistance is a core feature of the MetS. HOMA-IR is a robust clinical and epidemiological marker of MetS. Adiponectin is an adipokine with insulin-sensitizing and anti-inflammatory functions; its levels decrease as number of components of MetS increases. High-molecular weight adiponectin (HMWA) is the multimer responsible for the relationship of adiponectin with insulin sensitivity. HOMA-IR and HMWA are suitable candidates for MetS biomarkers. The ratio of adiponectin to HOMA-IR has been validated as a powerful index of MetS and considered a better marker of its presence, than either HOMA-IR or adiponectin alone, in selected homogeneous populations. We compared the strength of association between HMWA, HOMA-IR and HMWA/HOMA-IR ratio with MetS and its key components. Our data have shown that the median (25th, 75th percentile) of HMWA/HOMA-IR ratio was lower in subjects with MetS [0.51 (0.33, 1.31)] as compared to those without it [2.19 (1.13, 4.71)]. The correlation coefficient (r) was significantly higher for HMWA/HOMA-IR ratio as compared to HMWA for waist circumference (-0.65; -0.40, respectively); mean blood pressure (-0.27; -0.14, respectively); fasting glucose (-0.38; -0.19, respectively); HDL-cholesterol (0.44; 0.40, respectively); and triglycerides (-0.35; -0.18, respectively). In a multivariable logistic regression analysis, the HMWA/HOMA-IR ratio was a sensitive predictor for MetS, being the only marker that was significantly associated with each and all the individual components of the syndrome. These results expand on previous studies in that we used the active circulating form of adiponectin, i.e. HMWA, and represent a typical Brazilian cohort characterized by intense interethnic admixture. Thus, the HMWA/HOMA-IR ratio is a minimally invasive biomarker for MetS that could be

  18. Insulin resistance determined by Homeostasis Model Assessment (HOMA) and associations with metabolic syndrome among Chinese children and teenagers.

    Science.gov (United States)

    Yin, Jinhua; Li, Ming; Xu, Lu; Wang, Ying; Cheng, Hong; Zhao, Xiaoyuan; Mi, Jie

    2013-11-15

    The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among Chinese children and adolescents. Moreover, to determine the cut-off values for homeostasis model assessment of insulin resistance (HOMA-IR) at MS risk. 3203 Chinese children aged 6 to 18 years were recruited. Anthropometric and biochemical parameters were measured. Metabolic syndrome (MS) was identified by a modified Adult Treatment Panel III (ATP III) definition. HOMA-IR index was calculated and the normal reference ranges were defined from the healthy participants. Receiver operating characteristic (ROC) analysis was used to find the optimal cutoff of HOMA-IR for diagnosis of MS. With the increase of insulin resistance (quintile of HOMA-IR value), the ORs of suffering MS or its related components were significantly increased. Participants in the highest quintile of HOMA-IR were about 60 times more likely to be classified with metabolic syndrome than those in the lowest quintile group. Similarly, the mean values of insulin and HOMA-IR increased with the number of MS components. The present HOMA-IR cutoff point corresponding to the 95th percentile of our healthy reference children was 3.0 for whole participants, 2.6 for children in prepubertal stage and 3.2 in pubertal period, respectively. The optimal point for diagnosis of MS was 2.3 in total participants, 1.7 in prepubertal children and 2.6 in pubertal adolescents, respectively, by ROC curve, which yielded high sensitivity and moderate specificity for a screening test. According to HOMA-IR > 3.0, the prevalence of insulin resistance in obese or MS children were 44.3% and 61.6% respectively. Our data indicates insulin resistance is common among Chinese obese children and adolescents, and is strongly related to MS risk, therefore requiring consideration early in life. As a reliable measure of insulin resistance and assessment of MS risk, the optimal HOMA-IR cut

  19. EL UTILITARISMO DE JEREMY BENTHAM ¿FUNDAMENTO DE LA TEORÍA DE LEON WALRAS?

    Directory of Open Access Journals (Sweden)

    Aída-Sofía Rivera-Sotelo

    2011-12-01

    Full Text Available El presente texto cuestiona el utilitarismo de Jeremy Bentham como fundamento de la teoría marginalista walrasiana. La problemática se aborda a través de un análisis comparativo del pensamiento de Jeremy Bentham y de Leon Walras en tres áreas centrales: sus visiones de la sociedad y el objetivo social, sus aproximaciones teóricas y metodológicas en relación directa con sus respectivas teorías de la sociedad, y el lugar del principio de utilidad en el marco de las teorías generales de sociedad. El escrito contribuye a un debate vigente sobre los fundamentos filosóficos de la teoría de la elección racional y a deshomogenizar el pensamiento de los padres del marginalismo.

  20. The relationship between visfatin and HOMA-IR in hypertensive patients, and the effect of antihypertensive drugs on visfatin and HOMA-IR in hypertensive patients with insulin resistance.

    Science.gov (United States)

    Lan, Jianjun; Chen, Xiaoni; Chen, Xiaoping; Wang, Si; Zhang, Xin; Wu, Kai; He, Sen; Peng, Yong; Jiang, Lingyun; Li, Longxin; Wan, Liyan

    2011-10-01

    To investigate the correlation between serum visfatin and insulin resistance (IR) in non-diabetic essential hypertensive (EH) patients with and without IR, and to evaluate the effect of antihypertensive treatment on serum visfatin and IR in these patients. A total of 81 non-diabetic EH patients, including 54 with IR and 27 without IR, were enrolled. After two weeks wash-out, patients with IR were randomly assigned to telmisartan (group T) or amlodipine (group A) for 6 months. Blood samples were taken before and after treatment for measurement of routine biochemical parameters, visfatin and insulin resistance (measured by HOMA-IR). Visfatin was independently correlated with HOMA-IR (r=0.845, P=0.000). After 6 months of treatment, both drugs lowered HOMA-IR, more significantly so in group T than group A (P=0.010). Serum visfatin levels increased in group T but decreased in group A. Serum visfatin levels were higher in non-diabetic EH patients with IR compared with those without IR. Visfatin is independently correlated with HOMA-IR. Telmisartan lowers HOMA-IR to a greater extent than amlodipine. Interestingly, serum visfatin increased with telmisartan yet decreased with amlodipine treatment. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  1. The Triglycerides and Glucose Index rather than HOMA-IR is more associated with Hypogonadism in Chinese men.

    Science.gov (United States)

    Zhang, Kun; Chen, Yi; Liu, Lijie; Lu, Meng; Cheng, Jing; Gao, Fengbin; Wang, Ningjian; Shen, Zhoujun; Lu, Yingli

    2017-11-20

    Previous studies have reported that insulin resistant and low testosterone are related. The triglyceride and glucose index (TyG) well mirrors insulin sensitivity. No study investigated the application of TyG in male hypogonadism. We aimed to explore whether TyG was associated with hypogonadism, and also evaluate the ability of TyG compared to HOMA-IR as a possible hypogonadism predictor. A total of 4299 male subjects were enrolled from 22 sites in East China. Hypogonadism was defined as total testosterone HOMA-IR (0.68, 95% CI 0.66,0.70). Thus, the TyG was significantly associated with a higher prevalence of hypogonadism in Chinese men. TyG had a better predictive power for hypogonadism than HOMA-IR.

  2. TyG index, HOMA score and viral load in patients with chronic hepatitis C due to genotype 1.

    Science.gov (United States)

    Petta, S; Di Marco, V; Di Stefano, R; Cabibi, D; Cammà, C; Marchesini, G; Craxì, A

    2011-07-01

    The triglycerides × glucose (TyG) index is a recently proposed surrogate marker of insulin resistance (IR), calculated from fasting plasma triglyceride and glucose concentrations. We tested the host and viral factors associated with Tyg and homeostasis model assessment (HOMA) scores, comparing their associations with histological features and with sustained virological response (SVR) in patients with genotype 1 chronic hepatitis C(G1CHC). Three hundred and forty consecutive patients with G1CHC were considered. All had a liver biopsy scored by one pathologist for staging and grading (Scheuer), and graded for steatosis, which was considered moderate-severe if ≥30%. Anthropometric and metabolic measurements, including IR measured by both HOMA and TyG, were registered. By linear regression analysis, TyG was independently associated with waist circumference (WC), total cholesterol, presence of arterial hypertension, Log10 HCV-RNA and steatosis. Similarly, WC and steatosis were significantly associated with HOMA. Older age (OR, 1.036; 95%CI, 1.004-1.070, P = 0.02), higher WC (1.031; 1.004-1.060; P = 0.02) and higher TyG (11.496; 3.163-41.784; P HOMA-IR in the model, the latter remained significantly associated with steatosis ≥30% (1.237; 1.058-1.448; P = 0.008). Receiver operating characteristic curves showed a similar performance of TyG (AUC 0.682) and HOMA-IR (AUC 0.699) in predicting moderate-severe steatosis. No independent associations were found between both TyG and HOMA and fibrosis or SVR. In patients with G1CHC , TyG, an easy-to-calculate and low-cost surrogate marker of IR, is linked to liver steatosis and shows an independent association with viral load. © 2011 Blackwell Publishing Ltd.

  3. Early insulin sensitivity after restrictive bariatric surgery, inconsistency between HOMA-IR and steady-state plasma glucose levels.

    Science.gov (United States)

    van Dielen, Francois M H; Nijhuis, Jeroen; Rensen, Sander S M; Schaper, Nicolaas C; Wiebolt, Janneke; Koks, Afra; Prakken, Fred J; Buurman, Wim A; Greve, Jan Willem M

    2010-01-01

    The low-grade inflammatory condition present in morbid obesity is thought to play a causative role in the pathophysiology of insulin resistance (IR). Bariatric surgery fails to improve this inflammatory condition during the first months after surgery. Considering the close relation between inflammation and IR, we conducted a study in which insulin sensitivity was measured during the first months after bariatric surgery. Different methods to measure IR shortly after bariatric surgery have given inconsistent data. For example, the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels have been reported to decrease rapidly after bariatric surgery, although clamp techniques have shown sustained insulin resistance. In the present study, we evaluated the use of steady-state plasma glucose (SSPG) levels to assess insulin sensitivity 2 months after bariatric surgery. Insulin sensitivity was measured using HOMA-IR and SSPG levels in 11 subjects before surgery and at 26% excess weight loss (approximately 2 months after restrictive bariatric surgery). The SSPG levels after 26% excess weight loss did not differ from the SSPG levels before surgery (14.3 +/- 5.4 versus 14.4 +/- 2.7 mmol/L). In contrast, the HOMA-IR values had decreased significantly (3.59 +/- 1.99 versus 2.09 +/- 1.02). During the first months after restrictive bariatric surgery, we observed a discrepancy between the HOMA-IR and SSPG levels. In contrast to the HOMA-IR values, the SSPG levels had not improved, which could be explained by the ongoing inflammatory state after bariatric surgery. These results suggest that during the first months after restrictive bariatric surgery, HOMA-IR might not be an adequate marker of insulin sensitivity. Copyright 2010 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

  4. Higher HOMA-IR index and correlated factors of insulin resistance in patients with IgA nephropathy.

    Science.gov (United States)

    Yang, Yue; Wei, Ri-Bao; Wang, Yuan-da; Zhang, Xue-Guang; Rong, Na; Tang, Li; Chen, Xiang-Mei

    2012-11-01

    To investigate the index of homeostasis model of insulin resistance (HOMA-IR) in IgA nephropathy (IgAN) patients, and to explore the possible correlated factors contributing to insulin resistance (IR) within these patients. There were 255 IgAN patients and 45 membranous nephropathy (MN) patients in our database. We identified 89 IgAN subjects and 21 MN subjects without diabetes and undergoing glucocorticoid therapy for at least 6 months. Data regarding physical examination, blood chemistry and renal pathology were collected from 89 IgAN subjects and 21 MN subjects. Then 62 IgAN patients and 19 MN patients with chronic kidney disease (CKD) Stage 1 - 2 were selected for the comparison of HOMA-IR index, 89 IgAN patients were selected for multiple regression analysis to test for correlated factors of HOMA-IR index with IgAN patients. Comparison between IgAN and MN show that HOMA-IR index was significantly higher in IgAN patients with CKD Stage 1 - 2. After logarithmic transformation with urine protein (UPr), Ln(UPr) (b = 0.186, p = 0.008), eGFR (b = -0.005, p = 0.014), > 50% of glomeruli with mesangial hypercellularity (b = 0.285, p = 0.027) and body mass index (BMI) (b = 0.039, p = 0.008) were correlated factors of HOMA-IR index in the multiple regression analysis. IgAN patients had higher HOMA-IR index compared with MN in the stages of CKD 1 - 2. For IgAN patients, more UPr, lower eGFR, > 50% of glomeruli with mesangial hypercellularity and higher BMI were correlated with IR.

  5. Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA.

    Science.gov (United States)

    Oleastro, Monica; Cordeiro, Rita; Yamaoka, Yoshio; Queiroz, Dulciene; Mégraud, Francis; Monteiro, Lurdes; Ménard, Armelle

    2009-06-22

    homB encodes a Helicobacter pylori outer membrane protein. This gene was previously associated with peptic ulcer disease (PUD) and was shown to induce activation of interleukin-8 secretion in vitro, as well as contributing to bacterial adherence. Its 90%-similar gene, homA, was previously correlated with gastritis. The present study aimed to evaluate the gastric disease association with homB and homA, as well as with the H. pylori virulence factors cagA, babA and vacA, in 415 H. pylori strains isolated from patients from East Asian and Western countries. The correlation among these genotypes was also evaluated. Both homB and homA genes were heterogeneously distributed worldwide, with a marked difference between East Asian and Western strains. In Western strains (n = 234, 124 PUD and 110 non-ulcer dyspepsia (NUD), homB, cagA and vacA s1 were all significantly associated with PUD (p = 0.025, p = 0.014, p = 0.039, respectively), and homA was closely correlated with NUD (p = 0.072). In East Asian strains (n = 138, 73 PUD and 65 NUD), homB was found more frequently than homA, and none of these genes was associated with the clinical outcome. Overall, homB was associated with the presence of cagA (p = 0.043) and vacA s1 (p homA was found more frequently in cagA-negative (p = 0.062) and vacA s2 (p homA copy number were observed, with a clear geographical specificity, suggesting an involvement of these genes in host adaptation. A correlation between the homB two-copy genotype and PUD was also observed, emphasizing the role of homB in the virulence of the strain. The global results suggest that homB and homA contribute to the determination of clinical outcome.

  6. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR 2) in Mild Subclinical Hypothyroid Subjects.

    Science.gov (United States)

    Sengupta, Shreejita; Jaseem, T; Ambalavanan, Jayachidambaram; Hegde, Anupama

    2018-04-01

    Despite various studies with conflicting results, the effect of thyroid hormones on lipids and insulin levels in dysthyroidism is of great interest. This case control study was aimed to perceive the existence of IR and dyslipidemia in mild subclinical hypothyroid subjects (TSH ≤ 9.9 µIU/ml) as compared to their age and gender matched euthyroid controls. Basic demographic information like height, weight was recorded. Serum samples of all the subjects were assayed for thyroid profile, lipid profile, blood glucose, HbA1C and insulin. BMI and insulin resistance was calculated. Compared to controls patients with mild subclinical hypothyroidism demonstrated hyperinsulinemia and dyslipidemia observed by the higher LDL cholesterol. A significantly positive correlation was observed for HOMA-IR with TSH and LDL cholesterol. Hence, even in the mild subclinical hypothyroid state assessment of thyroid function should be combined with estimation of plasma glucose, insulin and serum lipids to monitor and prevent its associated effects.

  7. Nutritional status, lipid profile and HOMA-IR in post-liver transplant patients.

    Science.gov (United States)

    Da Silva Alves, Vanessa; Hack Mendes, Roberta; Pinto Kruel, Cleber Dario

    2014-05-01

    A high prevalence of overweight, obesity, diabetes and dyslipidemia has been reported following liver transplantation (LT). Although these conditions are known to induce an increased risk for cardiovascular events, which are among the major causes of death in post-LT patients, much debate remains in the literature regarding the applicability of different nutritional assessments methods to this population. To assess the nutritional status, lipid profile, homeostatic model assessment of insulin resistance (HOMA-IR) and dietary intake adequacy in the post-LT period. Cross-sectional study of patients after a maximum of 2 years post-LT, involving the assessment of body mass index (BMI), percent weight loss, arm (AC) and arm muscle circumference (AMC), triceps skinfold (TSF), neck (NC) and waist (WC) circumference, lipid profile, HOMA-IR and percent adequacy of dietary intake. In the group of 36 patients, 61.1% were male, mean age 53.2 years (± 10.6). Severe weight loss was noted in 66.7% of patients. Most individuals were eutrophic according to BMI, AC and AMC, while TSF showed malnutrition, NC demonstrated overweight and WC showed metabolic risk. Dyslipidemia was diagnosed in 87.5% of patients, and insulin resistance in 57% of the patients. Most patients had adequate dietary intake, although the time since transplant was positively correlated with AC (r = 0.353; p = 0.035) and negatively correlated with vitamin A intake (r = - 0.382; p = 0.022), with the caloric adequacy (r = -0.338; p = 0.044) and vitamin A adequacy (r = -0.382; p = 0.021). Although anthropometry provided somewhat variable nutritional diagnoses, when combined with biochemical tests, findings showed the prevalence of cardiovascular risk. As such, patients should be provided with transdisciplinary assistance, and strategies should be developed so as to reduce the risk factors recorded in this population. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  8. Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study.

    Science.gov (United States)

    Isokuortti, Elina; Zhou, You; Peltonen, Markku; Bugianesi, Elisabetta; Clement, Karine; Bonnefont-Rousselot, Dominique; Lacorte, Jean-Marc; Gastaldelli, Amalia; Schuppan, Detlef; Schattenberg, Jörn M; Hakkarainen, Antti; Lundbom, Nina; Jousilahti, Pekka; Männistö, Satu; Keinänen-Kiukaanniemi, Sirkka; Saltevo, Juha; Anstee, Quentin M; Yki-Järvinen, Hannele

    2017-10-01

    Recent European guidelines for non-alcoholic fatty liver disease (NAFLD) call for reference values for HOMA-IR. In this study, we aimed to determine: (1) the upper limit of normal HOMA-IR in two population-based cohorts; (2) the HOMA-IR corresponding to NAFLD; (3) the effect of sex and PNPLA3 genotype at rs738409 on HOMA-IR; and (4) inter-laboratory variations in HOMA-IR. We identified healthy individuals in two population-based cohorts (FINRISK 2007 [n = 5024] and the Programme for Prevention of Type 2 Diabetes in Finland [FIN-D2D; n = 2849]) to define the upper 95th percentile of HOMA-IR. Non-obese individuals with normal fasting glucose levels, no excessive alcohol use, no known diseases and no use of any drugs were considered healthy. The optimal HOMA-IR cut-off for NAFLD (liver fat ≥5.56%, based on the Dallas Heart Study) was determined in 368 non-diabetic individuals (35% with NAFLD), whose liver fat was measured using proton magnetic resonance spectroscopy ( 1 H-MRS). Samples from ten individuals were simultaneously analysed for HOMA-IR in seven European laboratories. The upper 95th percentiles of HOMA-IR were 1.9 and 2.0 in healthy individuals in the FINRISK (n = 1167) and FIN-D2D (n = 459) cohorts. Sex or PNPLA3 genotype did not influence these values. The optimal HOMA-IR cut-off for NAFLD was 1.9 (sensitivity 87%, specificity 79%). A HOMA-IR of 2.0 corresponded to normal liver fat (HOMA-IR measured in Helsinki corresponded to 1.3, 1.6, 1.8, 1.8, 2.0 and 2.1 in six other laboratories. The inter-laboratory CV% of HOMA-IR was 25% due to inter-assay variation in insulin (25%) rather than glucose (5%) measurements. The upper limit of HOMA-IR in population-based cohorts closely corresponds to that of normal liver fat. Standardisation of insulin assays would be the first step towards definition of normal values for HOMA-IR.

  9. Fundamentos del diseño de interacción

    OpenAIRE

    Verdines, Patricia; Campbell, Moraima

    2012-01-01

    El objetivo de este eBook es desarrollar hablidades para aplicar el proceso de diseño centrado en el usuario al generar productos, aplicaciones y ambientes de información interactivos. Por lo anterior esta obra es una introducción al área de diseño interactivo, los fundamentos en los que se basa, la importancia de considerar a los usuarios como parte central del proceso creativo en todas las etapas del sieño y los enfoques para llevar a cabo el p...

  10. Fundamentos de Inteligencia Artificial: Entrevista con Antonio Benítez

    OpenAIRE

    Asier Arias

    2012-01-01

    Antonio Benítez, profesor de Lógica en la Universidad Complutense de Madrid, ha dedicado buena parte de su labor docente e investigadora a la inteligencia artificial y a la filosofía de la mente y de la ciencia cognitiva. Recientemente ha publicado una obra en tres volúmenes titulada Fundamentos de Inteligencia Artificial (el tercer volumen, dedicado a la inteligencia artificial bioinspirada, aparecerá en los próximos meses). La misma ofrece una guía práctica de introducción a la programación...

  11. Fundamentos filosóficos da proteção ambiental

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    Arnaldo Moraes Godoy

    2002-12-01

    Full Text Available The present research considers the philosophy basis of environment protection showing anthropologic reasons. Biological justifications with contemporary bases focus the nature's most intrinsic values. The compiled also analyses the economic and political bases in the Brazilian environment model used to attract external resource.O presente trabalho considera os fundamentos filosóficos da proteção ambiental, evidenciando razões antropocêntricas, em que pese esforço mais contemporâneo para justificativas biocêntricas, que focalizam a natureza por seus intrínsecos valores.

  12. Fundamentos sobre energia das ondas (e sistemas fotovoltaicos para bombagem de água)

    OpenAIRE

    Carneiro, Joaquim A. O.

    2017-01-01

    Texto de apoio às aulas da UC "Energias Renováveis II" do Mestrado em Ciências e Tecnologias do Ambiente Devido ao crescente aumento do consumo energético, os últimos anos têm sido caracterizados por uma aposta estratégica na procura de fontes de energia alternativas aos combustíveis fósseis tradicionais. Este documento aborda os principais fundamentos adstritos a dois diferentes tipos de fontes alternativas de energia, nomeadamente a energia das ondas do oceano e a energia solar fotovolta...

  13. Fundamentos del tipo de cambio real en Costa Rica (2001-2014)

    OpenAIRE

    Fonseca Hernández, Raúl; Rodríguez Ramos, Nancy; Martínez Arias, Emil

    2017-01-01

    El documento está orientado a profesionales de ciencias sociales con el objetivo de orientarles en la comprensión del comportamiento del Índice de Tipo de Cambio Real de Costa Rica (ITCER) en relación con sus fundamentos. Se utiliza el modelo teórico behavioral equilibrium exchange rate (BEER) para identificar y analizar los efectos en estas variables sobre el ITCER. Los seis indicadores analizados fueron: términos de intercambio, absorción fiscal, IED, tasa de interés real doméstica y produc...

  14. Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR.

    Science.gov (United States)

    Zhu, Yubing; Sun, Zhipeng; Du, Yanmin; Xu, Guangzhong; Gong, Ke; Zhu, Bin; Zhang, Nengwei

    2017-01-01

    Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastric bypass surgery (LGB) in Beijing Shijitan Hospital from April 1, 2012 to April 1, 2013. The laboratory and anthropometric data was analyzed pre-surgery and during a 2-year follow-up. HOMA-IR was calculated and evaluated. The two surgical procedures were compared. No significant difference in complete remission rate was observed between the two groups (LGB group: 62.1%, LSG group: 60.0%, p = 0.892). HOMA-IR was reduced to a stable level at the 3 rd month after surgery. The cut-off value of HOMA-IR was 2.38 (sensitivity: 0.938, specificity: 0.75) and 2.33 (sensitivity: 0.941, specificity: 0.778) respectively for complete remission after LSG or LGB surgery. Insulin resistance was improved while GLP-1 and Ghrelin was changed significantly in patients with type 2 diabetes prior to weight loss either in the LSG or LGB group. HOMA-IR decreased to less than the cut-off value at the 3 rd month and was closely related to complete remission. The mechanism of bariatric surgery was not due just to simply dietary factors or body weight loss but also the remission of insulin resistance.

  15. HOMA-IR Values are Associated With Glycemic Control in Japanese Subjects Without Diabetes or Obesity: The KOBE Study.

    Science.gov (United States)

    Hirata, Takumi; Higashiyama, Aya; Kubota, Yoshimi; Nishimura, Kunihiro; Sugiyama, Daisuke; Kadota, Aya; Nishida, Yoko; Imano, Hironori; Nishikawa, Tomofumi; Miyamatsu, Naomi; Miyamoto, Yoshihiro; Okamura, Tomonori

    2015-01-01

    Several studies have reported that insulin resistance was a major risk factor for the onset of type 2 diabetes mellitus in individuals without diabetes or obesity. We aimed to clarify the association between insulin resistance and glycemic control in Japanese subjects without diabetes or obesity. We conducted a community-based cross-sectional study including 1083 healthy subjects (323 men and 760 women) in an urban area. We performed multivariate regression analyses to estimate the association between the homeostasis model assessment of insulin resistance (HOMA-IR) values and markers of glycemic control, including glycated haemoglobin (HbA1c), 1,5-anhydroglucitol (1,5-AG), and fasting plasma glucose (FPG) levels, after adjustment for potential confounders. Compared with the lowest tertile of HOMA-IR values, the highest tertile was significantly associated with HbA1c and FPG levels after adjustment for potential confounders, both in men (HbA1c: β = 1.83, P = 0.001; FPG: β = 0.49, P HOMA-IR values was inversely associated with 1,5-AG levels compared with the lowest tertile (β = -18.42, P = 0.009) only in men. HOMA-IR values were associated with markers of glycemic control in Japanese subjects without diabetes or obesity. Insulin resistance may influence glycemic control even in a lean, non-diabetic Asian population.

  16. Insulin resistance index (HOMA-IR) levels in a general adult population: curves percentile by gender and age. The EPIRCE study.

    Science.gov (United States)

    Gayoso-Diz, Pilar; Otero-Gonzalez, Alfonso; Rodriguez-Alvarez, María Xosé; Gude, Francisco; Cadarso-Suarez, Carmen; García, Fernando; De Francisco, Angel

    2011-10-01

    To describe the distribution of HOMA-IR levels in a general nondiabetic population and its relationships with metabolic and lifestyles characteristics. Cross-sectional study. Data from 2246 nondiabetic adults in a random Spanish population sample, stratified by age and gender, were analyzed. Assessments included a structured interview, physical examination, and blood sampling. Generalized additive models (GAMs) were used to assess the effect of lifestyle habits and clinical and demographic measurements on HOMA-IR. Multivariate GAMs and quantile regression analyses of HOMA-IR were carried out separately in men and women. This study shows refined estimations of HOMA-IR levels by age, body mass index, and waist circumference in men and women. HOMA-IR levels were higher in men (2.06) than women (1.95) (P=0.047). In women, but not men, HOMA-IR and age showed a significant nonlinear association (P=0.006), with increased levels above fifty years of age. We estimated HOMA-IR curves percentile in men and women. Age- and gender-adjusted HOMA-IR levels are reported in a representative Spanish adult non-diabetic population. There are gender-specific differences, with increased levels in women over fifty years of age that may be related with changes in body fat distribution after menopause. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  17. Association between Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Components of Metabolic Syndrome in Young Chinese Men.

    Science.gov (United States)

    Ying, X; Song, Zh; Zhao, Ch; Jiang, Y

    2011-01-01

    To investigate the prevalence of metabolic syndrome (MetS) in young Chinese population and assess the association between HOMA-IR and different components of MetS in young Chinese men. Overall 5576 young Chinese subjects (age range [19-44 yr], 3636 men) were enrolled in, who visited our Health Care Center for a related health checkup from March to December 2008. The international diabetes federation (IDF) definition for MetS was used. The SPSS statistical package, version 11.5 was used for the statistical analysis. The prevalence of MetS was 21.81% in young men and 5.62% in young women. According to suffering from different numbers of MetS components, the male subjects were divided into four groups. Numbers of MetS components were more and HOMA-IR values were significantly higher. In this male population, the quartile of HOMA-IR was higher, values of triglyceride (TG), fasting plasma glucose (FBG), systolic blood pressure(SBP), diastolic blood pressure(DBP) and waist circumference (WC) were all significantly higher, as well as high density lipoprotein cholesterol (HDL-C) value was significantly lower (P= 0.000). In Spearman's correlation analysis, HOMA-IR was positively correlated with TG, FBG, SBP, DBP and WC, and negatively correlated with HDL-C (r= 0.460, 0.464, 0.362, 0.346, 0.586, -0.357, respectively, all P value= 0.000). The prevalence of MetS in these young Chinese men was obviously high. Insulin resistance played an important role in occurrence and development of MetS. Waist circumference was the best correlation with HOMA-IR among all components of MetS.

  18. [es] Los fundamentos normativos de las profesiones y los deberes de los trabajadores sociales

    Directory of Open Access Journals (Sweden)

    Damián Salcedo Megales

    2010-06-01

    Full Text Available En este artículo presento un esbozo de estructura de los valores del trabajo social que hagan posible una justificación racional de sus deberes y responsabilidades. Dicha estructura nos permite elaborar una concepción de la ética profesional que pone de relieve las facetas institucionales de los fundamentos de la práctica profesional. En ella, encuentran su lugar principios, reglas, normas, etc. y así surge una visión general de sus exigencias y relaciones. Por último, se realizan algunas reflexiones sobre la identidad profesional y los compromisos básicos con el cambio social que se deducen de la teoría sobre los fundamentos normativos del trabajo social que he ofrecido. I sketch a theoretical framework for social work values that make possible a rational justification for duties and responsibilities. It enables us to develop an approach to professional ethics stressing the institutional aspects of the ground for professional practice. Principles, rules, norms, etc. find their place in such framework and so a comprehensive understanding of its requirements and relations emerge. Some remarks, finally, on professional identity and basic commitments to social reform are deduced from the basic account of the normative foundations for social work I offer.

  19. Ideologias e regimes autocráticos chauvinistas: fundamentos e influências.

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    Jefferson Rodrigues Barbosa

    2015-12-01

    Full Text Available As ideologias chauvinistas são expressões de pensamentos nacionalistas exacerbados, caracterizados por debilidades argumentativas e fundamentalismos, que legitimam princípios de ordenamento social de caráter autocrático. A presente pesquisa investiga os fundamentos argumentativos presentes nos escritos de Benito Mussolini e Adolf Hitler, como expressões das concepções em questão. Em perspectiva crítica através da análise histórica e dos fundamentos da Teoria Política marxista, temas como Estado, partido e nação serão privilegiados com o objetivo de compreensão das aproximações e distanciamentos destas concepções legitimadoras de Estados de Exceção nas primeiras décadas do século XX, com experiências que ocorreram na América do Sul, especificamente o integralismo brasileiro.

  20. A study of insulin resistance by HOMA-IR and its cut-off value to identify metabolic syndrome in urban Indian adolescents.

    Science.gov (United States)

    Singh, Yashpal; Garg, M K; Tandon, Nikhil; Marwaha, Raman Kumar

    2013-01-01

    Insulin resistance (IR) and associated metabolic abnormalities are increasingly being reported in the adolescent population. Cut-off value of homeostasis model of assessment IR (HOMA-IR) as an indicator of metabolic syndrome (MS) in adolescents has not been established. This study aimed to investigate IR by HOMA-IR in urban Indian adolescents and to establish cut-off values of HOMA-IR for defining MS. A total of 691 apparently healthy adolescents (295 with normal body mass index (BMI), 205 overweight, and 199 obese) were included in this cross-sectional study. MS in adolescents was defined by International Diabetes Federation (IDF) and Adult Treatment Panel III (ATP III) criteria. IR was calculated using the HOMA model. Mean height, waist circumference (WC), waist/hip ratio (WHR), waist/height ratio (WHtR), and blood pressure were significantly higher in boys as compared to girls. The HOMA-IR values increased progressively from normal weight to obese adolescents in both sexes. Mean HOMA-IR values increased progressively according to sexual maturity rating in both sexes. HOMA-IR value of 2.5 had a sensitivity of >70% and specificity of >60% for MS. This cut-off identified larger number of adolescents with MS in different BMI categories (19.7% in normal weight, 51.7% in overweight, and 77.0% in obese subjects) as compared to the use of IDF or ATP III criteria for diagnosing MS. Odds ratio for having IR (HOMA-IR of >2.5) was highest with WHtR (4.9, p pHOMA-IR increased with sexual maturity and with progression from normal to obese. A HOMA-IR cut-off of 2.5 provided the maximum sensitivity and specificity in diagnosing MS in both genders as per ATP III and IDF criteria.

  1. Fundamentos macroeconômicos nas perspectivas de Marx e Keynes: contribuições para a heterodoxia

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    PEDRO GARRIDO DA COSTA LIMA

    2016-09-01

    Full Text Available RESUMO: A necessidade de definir fundamentos microeconômicos para os modelos macroeconômicos, presente no pensamento dominante na economia contemporânea, pode ser questionada com base em diferentes abordagens teóricas. Posições como as de Marx e Keynes permitem a apreensão das ações dos agentes econômicos (grupos ou classes como influenciadas e limitadas pelo ambiente social e macroeconômico, fornecendo visões de fundamentos macroeconômicos da microeconomia, ao invés da visão ortodoxa de fundamentos micro da macroeconomia. Essa forma de apreensão lança luz sobre diferenças de perspectivas da heterodoxia quando se trata de intervir sobre o contexto macroeconômico.

  2. Os Fundamentos da Caracterização do Direito ao Bom Ambiente do Trabalho como Direito Fundamental

    OpenAIRE

    Pes, João Hélio Ferreira

    2016-01-01

    Este trabalho objetiva verificar quais são os fundamentos da caracterização do direito ao bom ambiente do trabalho como direito fundamental. Inicialmente, conceitua o direito ao bom ambiente do trabalho. Logo a seguir, menciona a diferenciação entre fundamentalidade formal e fundamentalidade material do direito ao bom ambiente do trabalho à luz da teoria pós positivista. Por fim, apresenta alguns fundamentos substanciais da caracterização do direito ao bom ambiente do trabalho como direito fu...

  3. Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats

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    Javad Mehrabani

    2017-09-01

    Full Text Available The hypothalamus is a strong central controller of appetite that secretes different neuropeptides including AGRP. Plasma levels of AGRP are effective in controlling obesity and hunger. Therefore, the current study was performed with the aim of investigating the effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats. The Current study was experimental by posttest and control group. Eighteen male Wistar rats (200-220 grams with 8-10 weeks were randomly divided into the control group and diabetic training. Eight weeks endurance training program included in the group of animal diabetic training for 5 days per week (15-40 minutes at 50 to 65 percent of vo2max. To determine the serum concentrations of AGRP was used by ELISA. A comparison of two groups showed significantly increased plasma concentrations of AGRP (p=0.006 and insulin resistance index, decreased significantly (p=0.002 compared to the control group after eight weeks, endurance training. According to the results, increased plasma concentrations of AGRP can be attributed to the negative balance caused by training. This agent destroys the body's energy balance and hypothalamus for balancing increases the secretion of AGRP. This neuropeptide is likely will cause higher fat metabolism.

  4. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin

    Science.gov (United States)

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying

    2016-01-01

    Abstract This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels. A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index. After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend HOMA-IR index in the entire cohort, men, and women were 1.33 (1.10–1.62), 1.46 (1.08–1.98), and 1.47 (1.12–1.91), respectively. The combination of sleep deprivation with no naps or >30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24–3.51; HR = 4.00, 95% CI = 2.03–7.90; and HR = 2.05, 95% CI = 1.29–3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48–3.02; and HR = 1.35, 95% CI = 1.10–1.65, respectively). Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with brief daytime napping HOMA-IR index. PMID:26844520

  5. Utilidad del índice HOMA-IR con una sola determinación de insulinemia para diagnosticar resistencia insulínica Usefulness of HOMA-IR index with an only insulinemia determination to diagnose an insulin resistance

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    José Arturo Hernández Yero

    2011-08-01

    Full Text Available Introducción: el índice HOMA-IR es un procedimiento simple, poco invasivo, y que permite, mediante una fórmula validada y bien establecida, precisar un valor numérico expresivo de resistencia insulínica. Calcular el índice HOMA-IR con un solo valor de insulinemia pudiera presentar una mayor variabilidad, lo cual se trata de solucionar con al menos la media de 3 insulinemias, de acuerdo con la fórmula original. En varios estudios es habitual que se realice con una sola determinación de insulinemia. Por esa razón se decidió hacer un estudio en pacientes con diabetes tipo 2 y comparar los resultados en cuanto a sensibilidad y especificidad con una sola determinación de sangre para la insulinemia y glucemia. Objetivo: evaluar la sensibilidad y especificidad de cada una de las determinaciones de insulinemia realizadas cada 5 min contra la media de estas durante la aplicación de la fórmula para el índice HOMA-IR. Métodos: se estudiaron 60 pacientes con diagnóstico de diabetes tipo 2, que acudieron a los servicios de consulta externa y de orientación en el Centro de Atención al Diabético de La Habana. Tenían un tiempo de evolución de la diabetes menor de 5 años como promedio, con predominio en el sobrepeso corporal, fueron captados en un período de 6 meses de forma consecutiva, y se les realizaron determinaciones de insulinemias y glucemias en ayunas mediante trocar y extracción de sangre venosa a los 0,5 y 10 min, para realizarles el cálculo del modelo homeostático de Matthews conocido como HOMA-IR. Resultados: un 88,3 % tenía un HOMA-IR mayor de 3,2. La sensibilidad de una sola muestra de insulinemia, aunque elevada para confirmar el diagnóstico de resistencia insulínica, es variable, y la especificidad de una de las muestras resultó baja con un 14 %. Se aprecia una adecuada concordancia entre los valores predictivos positivos con la sensibilidad y los valores predictivos negativos con la especificidad de la prueba

  6. Validation of HOMA-IR in a model of insulin-resistance induced by a high-fat diet in Wistar rats.

    Science.gov (United States)

    Antunes, Luciana C; Elkfury, Jessica L; Jornada, Manoela N; Foletto, Kelly C; Bertoluci, Marcello C

    2016-04-01

    Objective The present study aimed to validate homeostasis model assessment of insulin resistance (HOMA-IR) in relation to the insulin tolerance test (ITT) in a model of insulin-resistance in Wistar rats induced by a 19-week high-fat diet. Materials and methods A total of 30 male Wistar rats weighing 200-300 g were allocated into a high-fat diet group (HFD) (55% fat-enriched chow, ad lib, n = 15) and a standard-diet group (CD) standard chow, ad lib, n = 15), for 19 weeks. ITT was determined at baseline and in the 19th week. HOMA-IR was determined between the 18-19th week in three different days and the mean was considered for analysis. Area under the curve (AUC-ITT) of the blood glucose excursion along 120 minutes after intra-peritoneal insulin injection was determined and correlated with the corresponding fasting values for HOMA-IR. Results AUC-ITT and HOMA-IR were significantly greater after 19th week in HFD compared to CD (p HOMA-IR was strongly correlated (Pearson's) with AUC-ITT r = 0.637; p HOMA-IR and AUC-ITT showed similar sensitivity and specificity. Conclusion HOMA-IR is a valid measure to determine insulin-resistance in Wistar rats. Arch Endocrinol Metab. 2016;60(2):138-42.

  7. Clinical and Biochemical Profiles according to Homeostasis Model Assessment-insulin Resistance (HOMA-IR) in Korean Women with Polycystic Ovary Syndrome.

    Science.gov (United States)

    Lee, Da Eun; Park, Soo Yeon; Park, So Yun; Lee, Sa Ra; Chung, Hye Won; Jeong, Kyungah

    2014-12-01

    The aim of this study was to investigate the clinical and biochemical profiles according to homeostasis model assessment of insulin resistance (HOMA-IR) in Korean polycystic ovary syndrome (PCOS) patients. In 458 PCOS patients diagnosed by the Rotterdam European Society for Human Reproduction and Embryology (ESHRE) criteria, measurements of somatometry, blood test of hormones, glucose metabolic and lipid profiles, and transvaginal or transrectal ultrasonogram were carried out. HOMA-IR was then calculated and compared with the clinical and biochemical profiles related to PCOS. The patients were divided into 4 groups by quartiles of HOMA-IR. The mean level of HOMA-IR was 2.18 ± 1.73. Among the four groups separated according to HOMA-IR, body weight, body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, lipid accumulation product (LAP) index, high-sensitivity C-reactive protein (hs-CRP), Apoprotein B, free testosterone, and sex hormone binding globulin (SHBG) were found to be significantly different. TG, LAP index, glucose metabolic profiles, and hs-CRP were positively correlated with HOMA-IR after adjustment for BMI. Our results suggest that the clinical and biochemical profiles which are applicable as cardiovascular risk factors are highly correlated with HOMA-IR in Korean women with PCOS.

  8. FUNDAMENTOS DA EDUCAÇÃO INTEGRAL POLITÉCNICA: DA TEORIA À PRÁTICA

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    Antonio Carlos Maciel

    Full Text Available RESUMO: Este artigo tem por objetivo apresentar os fundamentos epistemológicos, pedagógicos e políticos de uma proposta de educação integral, concebida à luz da pedagogia histórico-crítica e orientada pelo princípio pedagógico da politecnia. Para tanto, resgata-se a noção desse conceito, desde a concepção marxiana até as interpretações realizadas por alguns dos principais autores brasileiros da área, cujo suporte teórico foi posto em prática, na forma de laboratório social, entre janeiro de 2005 e agosto de 2006, na cidade rondoniense de Ariquemes, com resultados que demonstraram a viabilidade de um modelo de educação integral que visa à emancipação humana sob a perspectiva marxista.

  9. Fundamentos del proceso lector. Motivar la lectura en la educación secundaria

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    Bartolomé Delgado Cerrillo

    2007-01-01

    Full Text Available Ante la alarma social provocada por los bajos resultados de los alumnos en "comprensión lectora" (Informe Pisa, pruebas de evaluación..., así como por el interés decreciente por la lectura en el paso de la infancia a la adolescencia, se hace necesario reflexionar sobre los fundamentos del proceso lector, al objeto de diseñar unas actividades de motivación y animación a la lectura en educación secundaria. Nuestra propuesta se incardina en el aula, ya que partimos de la necesidad de relacionar los libros con la consecución real de información, placer y entretenimiento. El estudiante debe saber para qué, cómo, acerca de qué, cuándo, dónde¿ leer de manera provechosa y grata.

  10. Fundamentos de Inteligencia Artificial: Entrevista con Antonio Benítez

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    Asier Arias

    2012-07-01

    Full Text Available Antonio Benítez, profesor de Lógica en la Universidad Complutense de Madrid, ha dedicado buena parte de su labor docente e investigadora a la inteligencia artificial y a la filosofía de la mente y de la ciencia cognitiva. Recientemente ha publicado una obra en tres volúmenes titulada Fundamentos de Inteligencia Artificial (el tercer volumen, dedicado a la inteligencia artificial bioinspirada, aparecerá en los próximos meses. La misma ofrece una guía práctica de introducción a la programación en inteligencia artificial de clara y cabal factura, además de una cuidada introducción a los aspectos teóricos de la disciplina. En esta entrevista nos habla de esta obra y de la ciencia cognitiva en general.

  11. O neoliberalismo como um dos fundamentos da educação domiciliar

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    Romualdo Luiz Portela de Oliveira

    Full Text Available Resumo Este artigo tem como objetivo analisar o neoliberalismo como um dos fundamentos da educação domiciliar, fenômeno de interesse crescente no Brasil, dada a tentativa de regulamentá-lo no país. Para tanto, foram tomados como referência três autorizados representantes do neoliberalismo: Friedrich Hayek; Milton Friedman e Ludwig von Mises e a reiterada preocupação destes com as liberdades, sobretudo as individuais. O artigo argumenta que o neoliberalismo se apresenta como uma das correntes teóricas que também dá suporte ao homeschooling, tendo como ponto crucial de sua fundamentação a rejeição da compulsoriedade da educação escolar, o que gera fortes implicações para o debate educacional, principalmente como desafios à escola pública compulsória.

  12. A Construção dos Fundamentos Conceituais da Economia Solidária

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    Dyego de Oliveira Arruda

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/2175-7984.2013v12n25p99 O presente trabalho tem como objetivo geral lançar luz acerca dos fundamentos basilares da economia solidária, situando-a no que tange aos aspectos históricos, sociológicos e até mesmo econômicos que lhe são pertinentes. Entende-se que a economia solidária – como quadro referencial das ciências sociais – erigiu-se numa perspectiva de adaptação/negação dos desígnios acumulativos e excludentes do modo de produção capitalista, numa tentativa de humanização deste sistema. Logo, todo o quadro analítico da economia solidária foi construído neste trabalho a partir desta perspectiva de adaptação/negação dos fundamentos basilares do sistema capitalista. Trata-se, portanto, de um artigo decorrente de uma pesquisa essencialmente qualitativa, de caráter descritivo e exploratório – sobretudo por conta da contemporaneidade do tema. Entende-se que, mediante ao levantamento das informações, urgem pesquisas acerca das próprias práticas de economia solidária contemporâneas, situando-as no seio das políticas públicas, bem como no âmbito da evolução da economia solidária enquanto movimento organizado.

  13. Los derechos fundamentales y el respeto por la diferencia: fundamentos del Estado Constitucional de Derecho

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    Juan Carlos De Los Rios Castiblanco

    2012-01-01

    Full Text Available ResumenEn las siguientes líneas, se reconstruyen elementos históricos relevantes que incidieron en la consolidación del neoconstitucionalismo y se analizan algunos fundamentos e instituciones notables que inciden en los derechos de primera generación, con todas sus variaciones y cambios de tonalidad, así también el reconocimiento y garantismo de estos derechos fundamentales y principios ordenadores de justicia, como elementos estructurantes de un orden adaptado a la realidad. El neoconstitucionalismo es, en definitiva, la apelación a la participación democrática dentro de las fronteras de los derechos fundamentales e inalienables del ser humano, cuya realidad es impulsada por una jurisdicción constitucional que se basa en diversos instrumentos jurídicos como el control de constitucionalidad, lo que en últimas se traduce en la búsqueda del respeto por la diferencia y la realización de los derechos esenciales de las minorías.Palabras clavesDerechos fundamentales, respeto por la diferencia, fundamentos del Estado constitucional de derecho.AbstractIn the following lines, rebuilds relevant historical elements that influenced neoconstitutionalism consolidation and discusses some notable foundations and institutions that affect the rights of the first generation, with all its variations and changes of hue, so the recognition and state protection of these fundamental rights and ordering principles of justice, as an order structuring elements adapted to reality. Neoconstitutionalism is ultimately appeal to democratic participation within the boundaries of the fundamental and inalienable rights of the human being, whose reality is driven by a constitutional court which is based on legal instruments such as the control of constitutionality, which ultimately results in the search for respect for difference and the realization of the basic rights of minorities.Key wordsFundamental rights, respect for difference, fundamentals of the state

  14. A Calcium-Deficient Diet in Rat Dams during Gestation Decreases HOMA-β% in 3 Generations of Offspring.

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    Takaya, Junji; Yamanouchi, Sohsaku; Tanabe, Yuko; Kaneko, Kazunari

    2016-01-01

    Prenatal malnutrition can affect the phenotype of offspring by altering epigenetic regulation. Calcium (Ca) plays an important role in the pathogenesis of insulin resistance syndrome. We hypothesized that a Ca-deficient diet during pregnancy would alter insulin resistance and secretion in more than 1 generation of offspring. Female Wistar rats consumed either a Ca-deficient or a control diet ad libitum from 3 weeks before conception to 21 days after parturition and were mated with control males. Randomly selected F1 and F2 females were mated with males of each generation on postnatal day 70. The F1 and F2 dams were fed a control diet ad libitum during pregnancy and lactation. All offspring were fed a control diet starting at the time of weaning and were sacrificed on day 180. HOMA-β% decreased in F1 through F3, and levels in F2 and F3 males and females were significantly lower than in controls. The mean levels of insulin and HOMA-IR were higher in F1 males but lower in F3 males than in control males. The HOMA-IR did not differ between any of the female offspring and controls. Maternal Ca restriction during pregnancy and/or lactation influences insulin secretion in 3 generations of offspring. © 2017 S. Karger AG, Basel.

  15. Limitations of the HOMA-B score for assessment of beta-cell functionality in interventional trials-results from the PIOglim study.

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    Pfützner, Andreas; Derwahl, Michael; Jacob, Stephan; Hohberg, Cloth; Blümner, Ernst; Lehmann, Ute; Fuchs, Winfried; Forst, Thomas

    2010-08-01

    Drugs with unspecific stimulating effects on beta-cell secretion increase the homeostasis model assessment (HOMA)-B score, indicating improved beta-cell "function." We investigated whether the beta-cell protection provided by adding pioglitazone (PIO) to glimepiride (GLIM) in comparison to up-titrating the GLIM dose alone is reflected by appropriate changes in several measures of beta-cell function, including HOMA-B score. This double-blind, parallel prospective 6-month study was performed with 82 patients (47 men, 35 women; age, 61 +/- 9 years; duration of disease, 5.3 +/- 4.4 years; body mass index, 32.6 +/- 6.0 kg/m(2); hemoglobin A1c [HbA1c], 7.3 +/- 0.7%) with GLIM monotherapy (1-3 mg). They were randomized to receive a GLIM + PIO combination with up-titration (2 mg + 30 mg/4 mg + 30 mg/4 mg + 4 mg) or to remain on GLIM (up-titration 4/5/6 mg). Observation parameters determined at baseline and end point included HOMA-B, HOMA-IR, HbA1c, glucose, insulin, and intact proinsulin. There was a slight increase in the HOMA-B score in the GLIM group but not in the GLIM + PIO arm (baseline/end point: for GLIM, 71 +/- 48/88 +/- 64; for PIO + GLIM, 74 +/- 56/69 +/- 52). Improvements in the other observation parameters were predominantly detected in the PIO + GLIM group (HbA1c, 7.20 +/- 0.61%/6.36 +/- 0.90%; HOMA-IR, 7.0 +/- 4.5/4.1 +/- 2.1; intact proinsulin, 12.4 +/- 10.3/7.6 +/- 4.8 pmol/L [all P HOMA-IR, 7.4 +/- 4.5/7.5 +/- 4.3 [not significant]; intact proinsulin, 17.3 +/- 21.6/16.3 +/- 15.5 pmol/L [not significant]). The PIO + GLIM combination led to overall improvement of laboratory biomarkers for beta-cell function, except for HOMA-B. Glimepiride up-titration had no such effects but increased the HOMA-B score. HOMA-B seems to provide misleading results when used as a diagnostic tool in patients treated with sulfonylurea drugs. A corrective term for consideration of proinsulin in the HOMA-B equation may address this limitation.

  16. Correlation Between Glycated Hemoglobin and Homa Indices in Type 2 Diabetes Mellitus: Prediction of Beta-Cell Function from Glycated Hemoglobin.

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    Al-Hakeim, Hussein Kadhem; Abdulzahra, Mohammed Saied

    2015-04-01

    The present study aimed to determine the most efficient insulin resistance function related to glycemic control expressed as glycated hemoglobin (HbA1c) in type 2 diabetes mellitus patients (T2DM). The other aim is to derive equations for the prediction of beta cell functions containing HbA1c as a parameter in addition to fasting glucose and insulin. T2DM Patients were grouped according to the following: (1) degree of control (good, fair, and poor control) and (2) insulin resistance as observed in obtained data and significant differences revealed by the homeostasis model assessment (HOMA) of related parameters (insulin resistance = HOMA2IR, beta-cell function = HOMA%B, and insulin sensitivity = HOMA%S) among groups. Correlations and forecasting regression analysis were calculated. HbA1c was found to be correlated with insulin resistance parameters in T2DM subgroups. This correlation was also significantly correlated with HOMA%B and the quantitative insulin sensitivity check index (QUICKI) in fair and poor control groups. Regression analysis was used to predict the forecasting equations for HOMA%B. The best applicable equations were derived for healthy control (HOMA2%B=-1.76*FBG+5.00*Insulin+4.69*HbA1c+189.84) and poor control groups (HOMA2%B=0.001* FBG+0.5*Insulin-8.67*HbA1c+101.96). These equations could be used to predict β-cell function (HOMA%B) after FBG, insulin and HbA1c values were obtained for healthy and poor control groups. In the good and fair control groups, the applicability of the HOMA model fails to yield appropriate results. Beta-cell function is correlated with QUICKI and HbA1c and could be predicted properly from HbA1c, insulin, and glucose in the healthy and poor control groups. New regression equations were established that involve HbA1c.

  17. Fasting serum insulin and the homeostasis model of insulin resistance (HOMA-IR) in the monitoring of lifestyle interventions in obese persons.

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    Vogeser, Michael; König, Daniel; Frey, Ingrid; Predel, Hans-Georg; Parhofer, Klaus Georg; Berg, Aloys

    2007-09-01

    Lifestyle changes with increased physical activity and balanced energy intake are recognized as the principal interventions in obesity and insulin resistance. Only few prospective studies, however, have so far addressed the potential role of routine biochemical markers of insulin sensitivity in the monitoring of respective interventions. Fasting insulin and glucose was measured in 33 obese individuals undergoing a lifestyle modification program (MOBILIS) at baseline and after 1 year. The HOMA-IR index (homeostasis model of insulin resistance) was calculated as [fasting serum glucose*fasting serum insulin/22.5], with lower values indicating a higher degree of insulin sensitivity. While the median body mass index (BMI) and waist circumference decreased by 10% and 11%, respectively, the HOMA-IR index decreased in an over-proportional manner by 45% within 1 year (BMI baseline, median 35.7, interquartile range (IQR) 33.7-37.7; after 1 year, median 32.2, IQR 29.6-35.1. HOMA-IR baseline, median 2.9, IQR 1.5-4.6; after 1 year 1.6, IQR 0.9-2.7). In contrast to HOMA-IR and fasting serum insulin, no significant changes in fasting serum glucose were observed. Baseline and post-intervention HOMA-IR showed a high degree of inter-individual variation with eight individuals maintaining high HOMA-IR values despite weight loss after 1 year of intervention. Individual changes in the carbohydrate metabolism achieved by a lifestyle intervention program were displayed by fasting serum insulin concentrations and the HOMA-IR but not by fasting glucose measurement alone. Therefore, assessment of the HOMA-IR may help to individualize lifestyle interventions in obesity and to objectify improvements in insulin sensitivity after therapeutic lifestyle changes.

  18. Association between β-cell function estimated by HOMA-β and prognosis of non-diabetic patients with ischaemic stroke.

    Science.gov (United States)

    Zhou, M; Pan, Y; Jing, J; Wang, Y; Zhao, X; Liu, L; Li, H; Wang, Y

    2018-03-01

    Studies showed that β-cell dysfunction is associated with increased risk of cardiovascular disease and subclinical carotid atherosclerosis. This study aimed to investigate the association between β-cell function and prognosis of non-diabetic patients with ischaemic stroke. Ischaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β-cell function (HOMA-β) was performed and classified into four groups according to quartiles. The outcomes included stroke recurrence, poor functional outcome and all-cause mortality. In a total of 1244 patients, the average age was 62.3 years; 63.1% patients were male. At 1 year, the first quartile of HOMA-β (HOMA-β (≥166.3) after adjustment for insulin resistance and other potential covariates. The second and third quartiles of HOMA-β were significantly associated with an increased risk of poor functional outcome. Multivariable regression analysis with restricted cubic splines showed an L-shaped association between HOMA-β and outcomes at 1 year. Our study shows that lower HOMA-β level is associated with poor outcomes at 1 year in non-diabetic patients with ischaemic stroke. © 2017 EAN.

  19. Dispersão de Fundamentos no Supremo Tribunal Federal / Scattered Arguments in Federal Supreme Court

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    Fábio Carvalho Leite

    2016-11-01

    Full Text Available Resumo: O trabalho analisa, em duas partes, o fenômeno conhecido por dispersão de fundamentos, prática decisória que por vezes marca o Supremo Tribunal Federal (STF no controle de constitucionalidade. A primeira parte é descritiva e sugere que a dispersão de fundamentos é fenômeno que ocorre pela presença necessária da regra de maioria decisória simples (RMDS associada à presença contingente do princípio da causa de pedir aberta e da indeterminação relativa do texto constitucional. A segunda parte é normativa e analisa criticamente os problemas resultantes da adoção da RMDS. Partindo-se do tradicional debate sobre a legitimidade do controle de constitucionalidade, porém não se alinhando a um modelo normativo em particular, o trabalho põe em xeque a proximidade do processo decisório do STF com a ideia de “resposta certa”, aborda a dificuldade de se formar jurisprudência capaz de uniformizar o tratamento de casos a respeito de um assunto e questiona a desconsideração da presunção de constitucionalidade nos casos difíceis do direito em que se verifiquem desacordos morais razoáveis. Por fim, a confiabilidade de intuições morais invocadas pelos ministros no processo decisório do STF é questionada a partir das ciências cognitivas e da psicologia moral. Palavras-chave: Supremo Tribunal Federal; Controle de constitucionalidade; Processo decisório; Dispersão de fundamentos.   Abstract: The work analyzes, in two parts, a phenomenon known as argument scatter, a decision-making practice that sometimes characterizes judicial review in the Brazilian Supreme Court (STF. The first part is descriptive, and suggests that argument scatter occurs in the necessary presence of a simple majority decision-making rule (SMDMR, associated to the contingent presence of the open cause of action principle and of the relative indeterminacy of constitutional text. The second part is normative, and critically analyzes the problems that

  20. Estimating Rate of Insulin Resistance in Patients with Preeclampsia Using HOMA-IR Index and Comparison with Nonpreeclampsia Pregnant Women

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    Farideh Rezaei Abhari

    2014-01-01

    Full Text Available Women with preeclampsia, independent of obesity and glucose intolerance, exhibit insulin resistance during pregnancy. The purpose of the present study is to determine whether early diagnosis of insulin resistance during pregnancy can predict preeclampsia. Through a case-control study, 675 pregnant women were selected and their first trimester blood was taken. Their fasting blood glucose and insulin were also measured after diagnosis of preeclampsia by 20 weeks of pregnancy. Based on the experiments conducted on 675 women who were 20 weeks past their pregnancy, 375 cases with preeclampsia were selected and assigned to the case group. 35 other pregnant women were put in the control group. Diagnosis criteria for the participants included blood pressure above 140/90 and proteinuria above 300 mg or above +1. Both groups were matched according to age, parity, gestational age, and BMI. Homa-Irand rate of insulin resistance was calculated by HOMA-IR and patients were followed up. Homeostatic model assessments (HOMA-IR revealed that the average insulin resistance increased during pregnancy among both the case and control groups. There was a significant difference between insulin resistance of these two groups in both first trimester and third trimester and after developing preeclampsia (P < 0.001, P = 0.021. Insulin-resistance of the group with preeclampsia was higher in first trimester prior to diagnosis as well as the third trimester after diagnosis compared to natural pregnancy under similar conditions. Measurement of insulin resistance in first trimester may be useful in predicting the risk of preeclampsia.

  1. Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods.

    Science.gov (United States)

    Kurtoğlu, Selim; Hatipoğlu, Nihal; Mazıcıoğlu, Mümtaz; Kendirici, Mustafa; Keskin, Mehmet; Kondolot, Meda

    2010-01-01

    Childhood obesity is associated with an increased risk for insulin resistance. The underlying mechanism for the physiological increase in insulin levels in puberty is not clearly understood. The aim of the present study was to determine the cut-off values for homeostasis model assessment for insulin resistance (HOMA-IR) in obese children and adolescents according to gender and pubertal status. Two hundred and eight obese children and adolescents (141 girls, 127 boys) aged between 5 and 18 years were included in the study. The children were divided into prepubertal and pubertal groups. A standard oral glucose tolerance test (OGTT) was carried out in all children. A total insulin level exceeding 300 μU/mL in the blood samples, collected during the test period, was taken as the insulin resistance criterion. Cut-off values for HOMA-IR were calculated by receiver operating characteristic (ROC) analysis. In the prepubertal period, the rate of insulin resistance was found to be 37% in boys and 27.8% in girls,while in the pubertal period, this rate was 61.7% in boys and 66.7% in girls. HOMA-IR cut-off values for insulin resistance in the prepubertal period were calculated to be 2.67 (sensitivity 88.2%, specificity 65.5%) in boys and 2.22 (sensitivity 100%, specificity 42.3%) in girls, and in the pubertal period, they were 5.22 (sensitivity 56%, specificity 93.3%) in boys and 3.82 (sensitivity 77.1%, specificity 71.4%) in girls. Since gender, obesity and pubertal status are factors affecting insulin resistance, cut-off values which depend on gender and pubertal status, should be used in evaluation of insulin resistance.

  2. Estimating rate of insulin resistance in patients with preeclampsia using HOMA-IR index and comparison with nonpreeclampsia pregnant women.

    Science.gov (United States)

    Abhari, Farideh Rezaei; Ghanbari Andarieh, Maryam; Farokhfar, Asadollah; Ahmady, Soleiman

    2014-01-01

    Women with preeclampsia, independent of obesity and glucose intolerance, exhibit insulin resistance during pregnancy. The purpose of the present study is to determine whether early diagnosis of insulin resistance during pregnancy can predict preeclampsia. Through a case-control study, 675 pregnant women were selected and their first trimester blood was taken. Their fasting blood glucose and insulin were also measured after diagnosis of preeclampsia by 20 weeks of pregnancy. Based on the experiments conducted on 675 women who were 20 weeks past their pregnancy, 375 cases with preeclampsia were selected and assigned to the case group. 35 other pregnant women were put in the control group. Diagnosis criteria for the participants included blood pressure above 140/90 and proteinuria above 300 mg or above +1. Both groups were matched according to age, parity, gestational age, and BMI. Homa-Irand rate of insulin resistance was calculated by HOMA-IR and patients were followed up. Homeostatic model assessments (HOMA-IR) revealed that the average insulin resistance increased during pregnancy among both the case and control groups. There was a significant difference between insulin resistance of these two groups in both first trimester and third trimester and after developing preeclampsia (P < 0.001, P = 0.021). Insulin-resistance of the group with preeclampsia was higher in first trimester prior to diagnosis as well as the third trimester after diagnosis compared to natural pregnancy under similar conditions. Measurement of insulin resistance in first trimester may be useful in predicting the risk of preeclampsia.

  3. Five-membered heterocycles. Part I. Application of the HOMA index to 1,2,4-trizoles

    Science.gov (United States)

    Mrozek, A.; Karolak-Wojciechowska, J.; Amiel, P.; Barbe, J.

    2000-06-01

    Aromaticity of the heterorings containing nitrogen, sulphur, and/or oxygen was studied on the basis of crystallographic data (CSD). The HOMA index, quantitative estimation of heteroring aromaticity, was calculated for pyrroles, thiophenes, furanes, pyrazoles, oksazoles, and imidazoles. For triazoles, used as a training set of molecules, correlation between heteroring aromaticity and number of substituents was indicated. At the same time, molecular structure of 3-amino-5-[2‧-diethylamino)ethylthio]-1,2,4-triazole hydrochloride was determined as a reference compound using X-ray crystallography.

  4. FUNDAMENTOS CONCEPTUALES DE UNA TEORÍA DE INTERFERENCIA UNIFICADA PARA ONDAS Y PARTÍCULAS

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    Román Castañeda

    2016-01-01

    Full Text Available La interferencia de la luz y de la materia se aborda de manera muy distinta, a pesar de que sea producida por arreglos experimentales con la misma configuración a escala diferente, que entregan resultados de morfología similar, llamados patrones de interferencia. El aparato matemático empleado para la predicción de los patrones de interferencia es similar y se basa en la superposición de funciones de onda. No obstante, mientras que en el caso de la luz la superposición de ondas es un principio fenomenológico que conduce a explicaciones físicas, en el caso de la materia, las funciones de onda no tienen significado físico, por lo que su superposición no conduce a explicaciones fenomenológicas. Así, fenómenos físicos análogos no se explican con base en causas naturales comunes y necesarias, como lo establecen las dos reglas de filosofía natural de Newton vigentes para el análisis de resultados experimentales. En este trabajo se proponen fundamentos conceptuales para una teoría basada en un nuevo principio físico de interferencia, tanto para luz como para la materia, que supera tales limitaciones y se ajusta a las reglas filosóficas de Newton.

  5. Fundamentos teóricos y estéticos del Nuevo Cine Latinoamericano

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    Silvana Flores

    2013-06-01

    Full Text Available Proponemos establecer un análisis de las bases teóricas y estéticas que fueron precursoras del programa político y estilístico del Nuevo Cine Latinoamericano a lo largo de las décadas. Estas se encuentran asociadas a la producción y recepción de las obras de arte en el contexto de la modernidad, y al desarrollo de una tendencia crítico-social en el arte latinoamericano de la primera mitad del siglo XX. De esta manera, demostraremos que el cine regionalista de América Latina en los años sesenta y setenta no se trató de un fenómeno circunscrito únicamente a los acontecimientos históricos que lo signaron, sino que también tuvo un fundamento que trascendió su época, y encuentra sus raíces en décadas precedentes, y en otras disciplinas estéticas.

  6. O SURGIMENTO DA ESCOLA DE PENSAMENTO DO MARKETING DE RELACIONAMENTO E SEUS FUNDAMENTOS

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    José Edson Lara

    2011-12-01

    Full Text Available O objetivo deste ensaio é discutir o surgimento do Marketing de Relacionamento (MR como escola de pensamento do marketing, após a década de 70. Primeiramente, será realizada uma revisão das principais escolas de marketing, conforme Sheth, Gardner e Garrett (1988. Considerando as influências de algumas dessas escolas sobre o Marketing de Relacionamento, será feito um resgate de seu surgimento, com a revisão de seus principais precursores e classificando-o nos critérios de interativo/não-interativo e econômico/não-econômico. Por fim, o artigo pretende responder às seguintes perguntas: O MR pode ser considerado hoje como escola proeminente no pensamento de marketing? É possível chegar a uma teoria geral para o MR? A objetividade nas pesquisas de MR é desejável/possível? A análise desses questionamentos será feita com base na discussão de correntes filosóficas do conhecimento científico (Comte, Durkhein, Popper, Nagel, Kant, Weber, que constituem fundamento epistemológico para o desenvolvimento de pesquisas da área.

  7. A Phýsis como fundamento do sistema filosófico estoico

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    Andityas Soares de Moura Costa Matos

    2010-06-01

    Full Text Available O presente artigo pretende demonstrar como a Física foi imprescindível para o sistema filosófico estoico, o que permitiu a sua utilização na Antiguidade como fundamento de todo o pensamento do Pórtico. Objetiva-se inferir tal papel preponderante reservado à Física estoica mediante a análise de alguns dos seus principais temas, tais como a Ontologia corporalista que a informa e as noções de lógos, deus e mistura total, concluindo-se o texto com uma breve exposição da teoria das conflagrações.The purpose of this paper is to demonstrate how Physics played a vital role in the development of the Stoic Philosophy System and allowed its use in ancient times as a basic element of the whole Portico's thought. This paper also intends to infer the significance of that role played by Stoic Physics, analyzing some of its main themes - the Ontology of the bodies, used, for instance, as an information source; and the notions of lógos, god and general mixture. Finally, the article provides a brief explanation of the conflagration theory.

  8. Dispositivos para generación de discurso y fundamentos conceptuales del trabajo infantil

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    Juan Manuel Estrada-Jiménez

    2015-03-01

    Full Text Available En este avance de investigación proponemos una metodología para el trabajo con niños y niñas, basada en dos dispositivos para la generación de discurso por medio de la actividad lúdica: un dispositivo destinado a la identificación de las dinámicas relacionales en el contexto de la familia, y otro orientado al reconocimiento de las formas en que se reproducen estas dinámicas en el entorno escolar. Igualmente presentamos las categorías analíticas que han servido para definir la situación de la infancia trabajadora, a partir de la identificación de temas centrales en el discurso de revistas especializadas sobre el tema, desplegando estas categorías como los fundamentos hermenéuticos que permitirán identificar a los niños y niñas como actores sociales productivos, y como ciudadanos y ciudadanas con derechos y deberes que demandan ser respetados.

  9. Fundamentos del tipo de cambio real en Costa Rica (2001-2014

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    Raúl Fonseca Hernández

    2017-05-01

    Full Text Available El documento está orientado a profesionales de ciencias sociales con el objetivo de orientarles en la comprensión del comportamiento del Índice de Tipo de Cambio Real de Costa Rica (ITCER en relación con sus fundamentos. Se utiliza el modelo teórico behavioral equilibrium exchange rate (BEER para identificar y analizar los efectos en estas variables sobre el ITCER. Los seis indicadores analizados fueron: términos de intercambio, absorción fiscal, IED, tasa de interés real doméstica y productividad relativa de la economía. Estos explican adecuadamente el comportamiento del tipo de cambio real, pese a presentar una gran variabilidad. Se identifican claramente dos periodos en el comportamiento del ITCER: el primero (2001 y 2005, se presenta un periodo de depreciación, observándose posteriormente (2006 y 2014 un marcado proceso de apreciación en términos reales del colón costarricense.

  10. Moralidade política e bioética: os fundamentos liberais da legitimidade do controle de constitucionalidade

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    Dutra, Delamar José Volpato

    2007-01-01

    Full Text Available O maior problema do controle de constitucionalidade - um dos institutos básicos do estado dedireito -, com relação à sua justificação democrática, é a chamada dificuldade contra-majoritária [countermajoritarian dificulty], já apontada por Bickel. O texto apresenta o tratamento dessa questão em Habermas, Rawls e Dworkin, a partir da bioética, especialmente o caso do aborto, da eutanasia e da eugenia. Argumenta-se que a justificação moral de boa parte do controle de constitucionalidade encontra sua base em fundamentos morais impostos ao legislador, a partir de uma perspectiva liberal. Tais fundamentos são reconstituidos, tendo em vista a posição tolerante de Locke concemente à problemática religiosa

  11. El utilitarismo de Jeremy Bentham ¿fundamento de la teoría de Leon Walras?

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    Rivera-Sotelo Aída-Sofía

    2011-12-01

    Full Text Available El presente texto cuestiona el utilitarismo de Jeremy Bentham como fundamento de la teoría marginalista walrasiana. La problemática se aborda a través de un análisis comparativo del pensamiento de Jeremy Bentham y de Leon Walras en tres áreas centrales: sus visiones de la sociedad y el objetivo social, sus aproximaciones teóricas y metodológicas en relación directa con sus respectivas teorías de la sociedad, y el lugar del principio de utilidad en el marco de las teorías generales de sociedad. El escrito contribuye a un debate vigente sobre los fundamentos filosóficos
    de la teoría de la elección racional y a deshomogenizar el pensamiento de los padres del marginalismo.

  12. Fundamentos Físicos de las Nuevas Tecnologías Informáticas: Enunciados de los problemas

    OpenAIRE

    Beléndez Vázquez, Augusto

    1996-01-01

    Fundamentos Físicos de las Nuevas Tecnologías Informáticas: Enunciados de los problemas (óptica geométrica, óptica ondulatoria, óptica de Fourier, holografía, óptica electromagnética, dispositivos electroópticos, dispositivos acustoópticos, fibras ópticas y comunicaciones, computación óptica).

  13. Six-month exenatide improves HOMA hyperbolic product in type 2 diabetic patients mostly by enhancing beta-cell function rather than insulin sensitivity.

    Science.gov (United States)

    Preumont, V; Hermans, M-P; Brichard, S; Buysschaert, M

    2010-09-01

    This study aimed to determine whether or not the improvement of glycaemic control with 6-month exenatide therapy in type 2 diabetic patients with secondary failure to combined oral therapy is related to amelioration of β-cell function and/or insulin sensitivity and their combined product. Thirty-three patients with type 2 diabetes were investigated. Their β-cell function and insulin sensitivity were measured using Homoeostasis Model Assessment [HOMA-B, HOMA-S and HOMA hyperbolic product (BxS)]. Additional endpoints included changes in weight, HbA(1c) and plasma adiponectin, as well as baseline clinical and biological characteristics, as potential predictors of HbA(1c) response. After 6 months, unadjusted HOMA-B increased from 33 ± 24% to 43 ± 23% (P=0.0210), whereas there was no significant change in HOMA-S (from 58 ± 35% to 61 ± 40%). The hyperbolic product increased by a relative 70% (from 15 ± 7% to 22 ± 15%; P=0.0055). Body mass index decreased from 32.2 ± 5.1 kg/m(2) to 31.0 ± 4.8 kg/m(2) (PHOMA-B and hyperbolic product over a 6-month treatment period with no overall change in insulin sensitivity, despite weight loss. Thus, improved β-cell function rather than increased insulin sensitivity accounts for the bulk of HbA(1c) reduction following 6 months of exenatide treatment. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  14. Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals.

    Science.gov (United States)

    Salgado, Ana Lúcia Farias de Azevedo; Carvalho, Luciana de; Oliveira, Ana Claudia; Santos, Virgínia Nascimento dos; Vieira, Jose Gilberto; Parise, Edison Roberto

    2010-01-01

    Due to its good correlation to glycemic clamp, HOMA-IR has been widely utilized as insulin resistance index in clinical and epidemiological studies involving non-alcoholic fatty liver disease carriers. However, values used for this parameter have shown large variability. To identify the HOMA-IR cut value that best distinguishes non-diabetic non-alcoholic fatty liver disease patients from a control group. One hundred sixteen non-alcoholic fatty liver disease patients were studied, diagnosed by clinical, biochemical, and liver image or biopsy criteria, and 88 healthy individuals, without any liver disease and testing for oral glucose tolerance within normality. These groups did not differ in age and gender. All were submitted to oral glucose tolerance test and blood samples were collected for glucose and insulin measurements by immunofluorometric method. HOMA-IR was calculated according to the formula: fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5. NAFLD patients showed higher insulin, glycemia, and HOMA-IR values than control group, even when excluding glucose intolerant and diabetes mellitus patients by their glycemic curves. HOMA-IR 75th percentile for control group was 1.78 and the best area under the curve index was obtained for HOMA-IR values of 2.0 [AUC= 0.840 (0.781-0.899 CI 95%), sensitivity (Se): 85%, specificity (Sp): 83%] while value 2.5 showed best specificity without important loss in sensitivity [AUC=0,831 (0.773-0.888) Se = 72%, Sp = 94%]. HOMA-IR values above or equal to 2.0 or 2.5 show enhanced diagnostic value in distinguishing non-alcoholic fatty liver disease carriers from control group individuals.

  15. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study.

    Science.gov (United States)

    Gayoso-Diz, Pilar; Otero-González, Alfonso; Rodriguez-Alvarez, María Xosé; Gude, Francisco; García, Fernando; De Francisco, Angel; Quintela, Arturo González

    2013-10-16

    Insulin resistance has been associated with metabolic and hemodynamic alterations and higher cardio metabolic risk. There is great variability in the threshold homeostasis model assessment of insulin resistance (HOMA-IR) levels to define insulin resistance. The purpose of this study was to describe the influence of age and gender in the estimation of HOMA-IR optimal cut-off values to identify subjects with higher cardio metabolic risk in a general adult population. It included 2459 adults (range 20-92 years, 58.4% women) in a random Spanish population sample. As an accurate indicator of cardio metabolic risk, Metabolic Syndrome (MetS), both by International Diabetes Federation criteria and by Adult Treatment Panel III criteria, were used. The effect of age was analyzed in individuals with and without diabetes mellitus separately. ROC regression methodology was used to evaluate the effect of age on HOMA-IR performance in classifying cardio metabolic risk. In Spanish population the threshold value of HOMA-IR drops from 3.46 using 90th percentile criteria to 2.05 taking into account of MetS components. In non-diabetic women, but no in men, we found a significant non-linear effect of age on the accuracy of HOMA-IR. In non-diabetic men, the cut-off values were 1.85. All values are between 70th-75th percentiles of HOMA-IR levels in adult Spanish population. The consideration of the cardio metabolic risk to establish the cut-off points of HOMA-IR, to define insulin resistance instead of using a percentile of the population distribution, would increase its clinical utility in identifying those patients in whom the presence of multiple metabolic risk factors imparts an increased metabolic and cardiovascular risk. The threshold levels must be modified by age in non-diabetic women.

  16. Evaluation of fasting plasma insulin concentration as an estimate of insulin action in nondiabetic individuals: comparison with the homeostasis model assessment of insulin resistance (HOMA-IR).

    Science.gov (United States)

    Abbasi, Fahim; Okeke, QueenDenise; Reaven, Gerald M

    2014-04-01

    Insulin-mediated glucose disposal varies severalfold in apparently healthy individuals, and approximately one-third of the most insulin resistant of these individuals is at increased risk to develop various adverse clinical syndromes. Since direct measurements of insulin sensitivity are not practical in a clinical setting, several surrogate estimates of insulin action have been proposed, including fasting plasma insulin (FPI) concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) calculated by a formula employing fasting plasma glucose (FPG) and FPI concentrations. The objective of this study was to compare FPI as an estimate of insulin-mediated glucose disposal with values generated by HOMA-IR in 758 apparently healthy nondiabetic individuals. Measurements were made of FPG, FPI, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) concentrations, and insulin-mediated glucose uptake was quantified by determining steady-state plasma glucose (SSPG) concentration during the insulin suppression test. FPI and HOMA-IR were highly correlated (r = 0.98, P HOMA-IR (r = 0.64). Furthermore, the relationship between FPI and TG (r = 0.35) and HDL-C (r = -0.40) was comparable to that between HOMA-IR and TG (r = 0.39) and HDL-C (r = -0.41). In conclusion, FPI and HOMA-IR are highly correlated in nondiabetic individuals, with each estimate accounting for ~40% of the variability (variance) in a direct measure of insulin-mediated glucose disposal. Calculation of HOMA-IR does not provide a better surrogate estimate of insulin action, or of its associated dyslipidemia, than measurement of FPI.

  17. HOMA insulin sensitivity index and the risk of all-cause mortality and cardiovascular disease events in the general population: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) study.

    Science.gov (United States)

    Barr, E L M; Cameron, A J; Balkau, B; Zimmet, P Z; Welborn, T A; Tonkin, A M; Shaw, J E

    2010-01-01

    We assessed whether the relationships between insulin sensitivity and all-cause mortality as well as fatal or non-fatal cardiovascular disease (CVD) events are independent of elevated blood glucose, high blood pressure, dyslipidaemia and body composition in individuals without diagnosed diabetes. Between 1999 and 2000, baseline fasting insulin, glucose and lipids, 2 h plasma glucose, HbA(1c), anthropometrics, blood pressure, medication use, smoking and history of CVD were collected from 8,533 adults aged >35 years from the population-based Australian Diabetes, Obesity and Lifestyle study. Insulin sensitivity was estimated by HOMA of insulin sensitivity (HOMA-%S). Deaths and fatal or non-fatal CVD events were ascertained through linkage to the National Death Index and medical records adjudication. After a median of 5.0 years there were 277 deaths and 225 CVD events. HOMA-%S was not associated with all-cause mortality. Compared with the most insulin-sensitive quintile, the combined fatal or non-fatal CVD HR (95% CI) for quintiles of decreasing HOMA-%S were 1.1 (0.6-1.9), 1.4 (0.9-2.3), 1.6 (1.0-2.5) and 2.0 (1.3-3.1), adjusting for age and sex. Smoking, CVD history, hypertension, lipid-lowering medication, total cholesterol and waist-to-hip ratio moderately attenuated this relationship. However, the association was rendered non-significant by adding HDL. Fasting plasma glucose, but not HOMA-%S significantly improved the prediction of CVD, beyond that seen with other risk factors. In this cohort, HOMA-%S showed no association with all-cause mortality and only a modest association with CVD events, largely explained by its association with HDL. Fasting plasma glucose was a better predictor of CVD than HOMA-%S.

  18. Influence of Grand Multiparity on the Levels of Insulin, Glucose and HOMA-IR in Comparison with Nulliparity and Primiparity.

    Science.gov (United States)

    Eldin Ahmed Abdelsalam, Kamal; Alobeid M Elamin, Abdelsamee

    2017-01-01

    It is to compare the levels of fasting glucose and insulin as well as insulin resistance in grand multiparas with primiparity and nulliparity. Fasting blood samples were collected from 100 non-pregnant ladies as control group, 100 primiparity pregnant women and 100 grand multiparity pregnant women. Glucose (FBS) and insulin (FSI) concentrations were measured by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure. Insulin resistance was calculated following the formula: FBG (mg dL-1)×FSI (μU mL-1)/405. This study found a significant reduction in glucose level in primiparity when compared to control group but it was increased significantly in multiparity comparing to primiparity and control. Insulin level showed significant high concentrations in pregnant women and increased significantly in grand multiparas comparing to primiparas and controls. As a result of that, HOMA-IR was increased significantly by increasing of parity. Also, there was a significant increase in fasting insulin and a decrease in insulin sensitivity with parity with association to age and obesity. Grand multiparity is associated with an increased risk of subsequent clinical insulin resistance (HOMA-IR).

  19. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors

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    R. Burrows

    2015-01-01

    Full Text Available Objective. To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR for diagnosis of the metabolic syndrome (MetS in adolescents and examine whether insulin resistance (IR, determined by this method, was related to genetic, biological, and environmental factors. Methods. In 667 adolescents (16.8 ± 0.3 y, BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured. Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry. Family history of type 2 diabetes (FHDM was reported. We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria using ROC analysis. IR was defined as HOMA-IR values above the cutoff. We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses. Results. Of the participants, 16% were obese and 9.4 % met criteria for MetS. The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6. Based on this value, 16.3% of participants had IR. Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR. FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR. Conclusions. In adolescents, HOMA-IR ≥ 2.6 was associated with greater cardiometabolic risk.

  20. Acculturation and psychosocial stress show differential relationships to insulin resistance (HOMA) and body fat distribution in two groups of blacks living in the US Virgin Islands.

    Science.gov (United States)

    Tull, Eugene S.; Thurland, Anne; LaPorte, Ronald E.; Chambers, Earle C.

    2003-01-01

    The objective of this study was to determine whether acculturation and psychosocial stress exert differential effects on body fat distribution and insulin resistance among native-born African Americans and African-Caribbean immigrants living in the US Virgin Islands (USVI). Data collected from a non-diabetic sample of 183 USVI-born African Americans and 296 African-Caribbean immigrants age > 20 on the island of St. Croix, USVI were studied. Information on demographic characteristics, acculturation and psychosocial stress was collected by questionnaire. Anthropometric measurements were taken, and serum glucose and insulin were measured from fasting blood samples. Insulin resistance was estimated by the homeostasis model assessment (HOMA) method. The results showed that in multivariate regression analyses, controlling for age, education, gender, BMI, waist circumference, family history of diabetes, smoking and alcohol consumption, acculturation was independently related to logarithm of HOMA (InHOMA) scores among USVI-born African Americans, but not among African-Caribbean immigrants. In contrast, among USVI-born African Americans psychosocial stress was not significantly related to InHOMA, while among African-Caribbean immigrants psychosocial stress was independently related to InHOMA in models that included BMI, but not in those which included waist circumference. This study suggests that acculturation and psychosocial stress may have a differential effect on body fat distribution and insulin resistance among native-born and immigrant blacks living in the US Virgin Islands. PMID:12911254

  1. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors.

    Science.gov (United States)

    Burrows, R; Correa-Burrows, P; Reyes, M; Blanco, E; Albala, C; Gahagan, S

    2015-01-01

    To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and examine whether insulin resistance (IR), determined by this method, was related to genetic, biological, and environmental factors. In 667 adolescents (16.8 ± 0.3 y), BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured. Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry. Family history of type 2 diabetes (FHDM) was reported. We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis. IR was defined as HOMA-IR values above the cutoff. We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses. Of the participants, 16% were obese and 9.4 % met criteria for MetS. The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6. Based on this value, 16.3% of participants had IR. Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR. FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR. In adolescents, HOMA-IR ≥ 2.6 was associated with greater cardiometabolic risk.

  2. Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study.

    Science.gov (United States)

    Yajnik, Chittaranjan S; Katre, Prachi A; Joshi, Suyog M; Kumaran, Kalyanaraman; Bhat, Dattatray S; Lubree, Himangi G; Memane, Nilam; Kinare, Arun S; Pandit, Anand N; Bhave, Sheila A; Bavdekar, Ashish; Fall, Caroline H D

    2015-07-01

    The Pune Children's Study aimed to test whether glucose and insulin measurements in childhood predict cardiovascular risk factors in young adulthood. We followed up 357 participants (75% follow-up) at 21 years of age who had undergone detailed measurements at 8 years of age (glucose, insulin, HOMA-IR and other indices). Oral glucose tolerance, anthropometry, plasma lipids, BP, carotid intima-media thickness (IMT) and arterial pulse wave velocity (PWV) were measured at 21 years. Higher fasting glucose, insulin and HOMA-IR at 8 years predicted higher glucose, insulin, HOMA-IR, BP, lipids and IMT at 21 years. A 1 SD change in 8 year variables was associated with a 0.10-0.27 SD change at 21 years independently of obesity/adiposity at 8 years of age. A greater rise in glucose-insulin variables between 8 and 21 years was associated with higher cardiovascular risk factors, including PWV. Participants whose HOMA-IR measurement remained in the highest quartile (n = 31) had a more adverse cardiovascular risk profile compared with those whose HOMA-IR measurement remained in the lowest quartile (n = 28). Prepubertal glucose-insulin metabolism is associated with adult cardiovascular risk and markers of atherosclerosis. Our results support interventions to improve glucose-insulin metabolism in childhood to reduce cardiovascular risk in later life.

  3. The Usefulness of Homeostatic Measurement Assessment-Insulin Resistance (HOMA-IR) for Detection of Glucose Intolerance in Thai Women of Reproductive Age with Polycystic Ovary Syndrome.

    Science.gov (United States)

    Wongwananuruk, Thanyarat; Rattanachaiyanont, Manee; Leerasiri, Pichai; Indhavivadhana, Suchada; Techatraisak, Kitirat; Angsuwathana, Surasak; Tanmahasamut, Prasong; Dangrat, Chongdee

    2012-01-01

    Objectives. To study the cut-off point of Homeostatic Measurement Assessment-Insulin Resistance (HOMA-IR) as a screening test for detection of glucose intolerance in Thai women with polycystic ovary syndrome (PCOS). Study Design. Cross-sectional study. Setting. Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital. Subject. Two hundred and fifty Thai PCOS women who attended the Gynecologic Endocrinology Unit, during May 2007 to January 2009. Materials and Methods. The paitents were interviewed and examined for weight, height, waist circumference, and blood pressure. Venous blood samples were drawn twice, one at 12-hour fasting and the other at 2 hours after glucose loading. Results. The prevalence of glucose intolerance in Thai PCOS women was 20.0%. The mean of HOMA-IR was 3.53  ±  7.7. Area under an ROC curve for HOMA-IR for detecting glucose intolerance was 0.82. Using the cut-off value of HOMA-IR >2.0, there was sensitivity at 84.0%, specificity at 61.0%, positive predictive value at 35.0%, negative predictive value at 93.8%, and accuracy at 65.6%. Conclusion. HOMA-IR >2.0 was used for screening test for glucose intolerance in Thai PCOS women. If the result was positive, a specific test should be done to prove the diagnosis.

  4. Matsuda-DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno-Sobetsu study.

    Science.gov (United States)

    Furugen, M; Saitoh, S; Ohnishi, H; Akasaka, H; Mitsumata, K; Chiba, M; Furukawa, T; Miyazaki, Y; Shimamoto, K; Miura, T

    2012-05-01

    Here we examined whether the Matsuda-DeFronzo insulin sensitivity index (ISI-M) is more efficient than the homeostasis model assessment of insulin resistance (HOMA-IR) for assessing risk of hypertension. Cross-sectional and longitudinal analyses were conducted using normotensive subjects who were selected among 1399 subjects in the Tanno-Sobetsu cohort. In the cross-sectional analysis (n=740), blood pressure (BP) level was correlated with HOMA-IR and with ISI-M, but correlation coefficients indicate a tighter correlation with ISI-M. Multiple linear regression analysis adjusted by age, sex, body mass index (BMI) and serum triglyceride level (TG) showed contribution of ISI-M and fasting plasma glucose, but not of HOMA-IR. In the longitudinal analysis (n=607), 241 subjects (39.7%) developed hypertension during a 10-year follow-up period, and multiple logistic regression indicated that age, TG, systolic BP and ISI-M, but not HOMA-IR, were associated with development of hypertension. In subjects HOMA-IR. Non-hepatic IR may be a determinant, which is independent of TG, BP level and BMI, of the development of hypertension.

  5. The Usefulness of Homeostatic Measurement Assessment-Insulin Resistance (HOMA-IR for Detection of Glucose Intolerance in Thai Women of Reproductive Age with Polycystic Ovary Syndrome

    Directory of Open Access Journals (Sweden)

    Thanyarat Wongwananuruk

    2012-01-01

    Full Text Available Objectives. To study the cut-off point of Homeostatic Measurement Assessment-Insulin Resistance (HOMA-IR as a screening test for detection of glucose intolerance in Thai women with polycystic ovary syndrome (PCOS. Study Design. Cross-sectional study. Setting. Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital. Subject. Two hundred and fifty Thai PCOS women who attended the Gynecologic Endocrinology Unit, during May 2007 to January 2009. Materials and Methods. The paitents were interviewed and examined for weight, height, waist circumference, and blood pressure. Venous blood samples were drawn twice, one at 12-hour fasting and the other at 2 hours after glucose loading. Results. The prevalence of glucose intolerance in Thai PCOS women was 20.0%. The mean of HOMA-IR was 3.53  ±  7.7. Area under an ROC curve for HOMA-IR for detecting glucose intolerance was 0.82. Using the cut-off value of HOMA-IR >2.0, there was sensitivity at 84.0%, specificity at 61.0%, positive predictive value at 35.0%, negative predictive value at 93.8%, and accuracy at 65.6%. Conclusion. HOMA-IR >2.0 was used for screening test for glucose intolerance in Thai PCOS women. If the result was positive, a specific test should be done to prove the diagnosis.

  6. Control fraccionario: fundamentos y guía de uso

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    Blas M. Vinagre

    2016-07-01

    Full Text Available Resumen: El objetivo del presente tutorial de control fraccionario es presentar los fundamentos de esta disciplina y las principales herramientas computacionales disponibles para su uso y aplicación por parte del ingeniero de control. El enfoque escogido pretende hacer accesible desde el primer momento su ubicación en el control clásico y las bases para entender cómo cualquier estrategia de control que haga uso de los operadores derivada y/o integral (es decir, casi todas puede generalizarse al considerar la posibilidad de utilizar dichos operadores con un orden no necesariamente entero. Los casos de estudio considerados (el doble integrador y el servomecanismo de posición han sido elegidos no para exponer las bondades del control fraccionario, sino para mostrar la amplitud de posibilidades que proporciona su utilización incluso considerando sistemas extraordinariamente comunes en la literatura de control. Abstract: The purpose of this tutorial on fractional control is to present the foundations of this discipline and the main computational tools available for its use and application by the control engineer. The chosen approach aims to make accessible from the very beginning its location in the classical control and the foundations for a clear understanding on how any control strategy that makes use of the derivative and / or the integral operators (i.e., almost all can be generalized by considering these operators with not necessarily integer order. The case studies considered (the double integrator and the position servo have been chosen not to expose the benefits of fractional control, but to show the range of possibilities that provides remarkably even considering its application to systems of common use in the literature of control. Palabras clave: Control fraccionario, Sistemas fraccionarios, Control robusto, Keywords: Fractional Control, Fractional Systems, Robust Control

  7. Fundamentos didácticos de la lengua y la literatura

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    María del Carmen Quiles Cabrera

    2013-06-01

    Full Text Available La enseñanza de la lengua es una cuestión sobre la que se viene reflexionando de forma intensa desde hace muchos años y especialmente a partir del último tercio del siglo XX, cuando la Didáctica de la Lengua y la Literatura se configura como disciplina autónoma de conocimiento. Durante todo este tiempo se ha ido edificando un marco para lo que ya entendemos como educación lingüística y literaria. Sin embargo, en este terreno – el de la educación- sabemos que nada es definitivo, nada es determinante, puesto que la escuela camina paralela a los cambios sociales. Las aulas del presente son muy distintas a las que conocimos en el pasado y, por lo tanto, tampoco serán iguales a las que están por llegar. Las didácticas específicas no quedan al margen de esta realidad, puesto que su función es hacer efectivo el conocimiento en el desarrollo integral de la persona. En este sentido, el libro Fundamentos didácticos de la lengua y la literatura ofrece una aportación, no sólo interesante, sino también necesaria para el ámbito de la educación lingüística y literaria en la actualidad, en un momento en el que apostar por la formación de las destrezas comunicativas supone la clave para desenvolvernos en una sociedad cambiante y de futuro incierto.

  8. Desenvolvimento de coleções: origem dos fundamentos contemporâneos

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    Simone da Rocha Weitzel

    Full Text Available O artigo apresenta o resultado de uma pesquisa cujo objetivo foi identificar as correspondências entre os fundamentos da área hoje denominada de desenvolvimento de coleções e aqueles estabelecidos no século XIX, a fim de reconstruir os principais conceitos, métodos e práticas da área. Propõe um estudo exploratório para viabilizar essa correspondência a partir de oito obras escolhidas de autores europeus do século XIX, a maioria bibliófilos reconhecidos, a saber: Peignot (1823, Namur (1834, Hesse (1841, Rouveyre (1878, Richard (1883, Gräsel (1893, Petzholdt (1894 e Maire (1896. Essas obras serão analisadas a partir de três categorias contemporâneas da área: desenvolvimento de coleções, seleção e aquisição, por meio do método de revisão de literatura. Conclui-se, por fim, que o fenômeno da explosão da informação afeta o processo de desenvolvimento de coleções como um todo desde o século XVIII. Os autores do século XIX selecionados para o estudo apresentaram várias soluções - as quais fortaleceram o que hoje é denominado de abordagem baseada no acesso à informação - para lidar com a complexidade gerada pelo fenômeno da explosão da informação.

  9. Dietary Calcium Intake May Contribute to the HOMA-IR Score in Korean Females with Vitamin D Deficiency (2008–2012 Korea National Health and Nutrition Examination Survey

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    Jin-Ho Kim

    2017-12-01

    Full Text Available Background : Vitamin D and calcium are important factors involved in the regulation of blood glucose and insulin secretion. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR score is a useful variable for evaluating insulin resistance, and therefore we cross-sectionally compared HOMA-IR scores according to serum vitamin D levels and dietary calcium intake. Methods : We selected data from healthy males (n=5,163 and females (n=7,506 analyzed over 5 years (2008–2012 via the Korea National Health and Nutrition Examination Survey (KNHANES. We calculated HOMA-IR scores and compared them according to serum 25-hydroxyvitamin D (25(OHD concentration classification (30 ng/mL and dietary calcium quintile after adjustment for relevant variables using complex sample analysis. Comparisons were done after data weighting. Results : The mean dietary calcium intake in males and females was 558.1 mg/day and 445.9 mg/day, respectively. The mean serum 25(OHD concentration in males and females was 19.4 ng/mL and 16.8 ng/mL, respectively. After adjustment for relevant variables, HOMA-IR score was significantly correlated with serum 25(OHD concentration and dietary calcium intake in females, whereas it was only correlated with serum 25(OHD concentration in males. HOMA-IR was significantly lower in the top quintile of dietary calcium intake (mean, 866 mg/day within females with vitamin D deficiency (P=0.047. Conclusion : Adequate dietary calcium intake may be important for normal HOMA-IR in females with vitamin D deficiency.

  10. Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program.

    Science.gov (United States)

    de Lima Sanches, Priscila; de Mello, Marco Túlio; Elias, Natália; Fonseca, Francisco Antonio Helfenstein; de Piano, Aline; Carnier, June; Oyama, Lila Missae; Tock, Lian; Tufik, Sergio; Dâmaso, Ana Raimunda

    2011-02-01

    The aim of this study was to verify whether a 1-year interdisciplinary weight-loss program improved common carotid artery intima-media thickness (IMT) and whether insulin resistance and/or inflammation (as measured by the markers plasminogen activator inhibitor type-1 and adiponectin) might underlie obesity in adolescents. A group of 29 post-pubescent obese adolescents were submitted to an interdisciplinary intervention over the course of 1 year. Common carotid artery IMT was determined ultrasonographically. Body composition, blood pressure (BP), glycemia, insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile and adipokine concentrations were analyzed before and after the intervention. The interdisciplinary weight-loss program promoted a significant improvement in body composition, insulin concentration, HOMA-IR, lipid profile, BP and inflammatory state, in addition to significantly decreasing the common carotid artery IMT. Furthermore, this study demonstrated that the difference between baseline and final values of HOMA-IR (ΔHOMA-IR) was negatively correlated with concomitant changes in the adiponectin concentration (Δadiponectin; r=-0.42; P=0.02) and positively correlated with changes in common carotid artery IMT (Δcarotid IMT; r=0.41; P=0.03). Multiple regression analysis adjusted by age, cardiovascular risk factors and inflammatory markers showed that ΔHOMA-IR was an independent predictor of significant changes in common carotid artery IMT. This investigation demonstrated that an interdisciplinary weight-loss program promoted a reduction of the common carotid artery IMT in obese Brazilian adolescents, and the improvement of HOMA-IR was an independent predictor of carotid IMT changes in this population.

  11. Is HOMA-IR a potential screening test for non-alcoholic fatty liver disease in adults with type 2 diabetes?

    Science.gov (United States)

    Gutierrez-Buey, Gala; Núñez-Córdoba, Jorge M; Llavero-Valero, María; Gargallo, Javier; Salvador, Javier; Escalada, Javier

    2017-06-01

    Non-alcoholic fatty liver disease (NAFLD) is the commonest hepatic disease in many parts of the World, with particularly high prevalence in patients with type 2 diabetes (T2DM). However, a good screening test for NAFLD in T2DM has not been established. Insulin resistance (IR) has been associated with NAFLD, and homeostatic model assessment of insulin resistance (HOMA-IR), a good proxy for IR, may represent an affordable predictive test which could be easily applied in routine clinical practice. We aimed to evaluate the diagnostic accuracy of HOMA-IR for NAFLD in T2DM and sought to estimate an optimal cut-off value for discriminating NAFLD from non-NAFLD cases. We conducted a retrospective analysis of 56 well-controlled patients with T2DM (HbAc1HOMA-IR and NAFLD was found (OR 1.5; 95% CI: 1.03-2.1; p=0.033), independently of transaminases, fat percentage, BMI and triglyceride levels. The AUROC curve of HOMA-IR for identifying NAFLD was 80.7% (95% CI: 68.9-92.5). A value of HOMA-IR of 4.5 was estimated to be an optimal threshold for discriminating NAFLD from non-NAFLD cases. HOMA-IR is independently associated with the presence of NAFLD in adults with T2DM, and might potentially be applied in clinical practice as a screen for this condition. Copyright © 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

  12. The effects of a 2 week modified high intensity interval training program on the homeostatic model of insulin resistance (HOMA-IR) in adults with type 2 diabetes.

    Science.gov (United States)

    Shaban, N; Kenno, K A; Milne, K J

    2014-04-01

    High intensity interval training (HIIT) induces similar metabolic adaptations to traditional steady state aerobic exercise training. Until recently, most HIIT studies have examined maximum efforts in healthy populations. The current study aimed to examine the effects of a 2 week modified HIIT program on the homeostatic model of insulin resistance (HOMA-IR) in individuals with type 2 diabetes (T2D). It was hypothesized that HIIT would improve HOMA-IR. Nine individuals with T2D (age=40.2±9.7 y; BMI=33.9±5.3; fasting plasma glucose [FPG]=8.7±2.9 mmol/L; HbA1C=7.3±1.2%; [mean±SD]) performed 6 individualized training sessions of HIIT (4x30 seconds at 100% of estimated maximum workload followed by 4 minutes of active rest) over 2 weeks. HOMA-IR was calculated from FPG and serum insulin and compared against a prior 2 week baseline period. Blood glucose was reduced immediately after each HIIT session (PHOMA-IR were unchanged after training. However, 6 of the 9 individuals exhibited reduced HOMA-IR values after the training period and there was a significant negative correlation between HOMA-IR value prior to training and change in HOMA-IR after HIIT. These observations tend to support the positive health benefits of HITT for individuals with T2D reported in recently published data using a modified HIIT protocol. However, they suggest that the magnitude of the disease should be assessed when examining the effects of exercise interventions in individuals with T2D.

  13. Lixisenatide as add-on treatment among patients with different β-cell function levels as assessed by HOMA-β index.

    Science.gov (United States)

    Bonadonna, Riccardo C; Blonde, Lawrence; Antsiferov, Mikhail; Berria, Rachele; Gourdy, Pierre; Hatunic, Mensud; Mohan, Viswanathan; Horowitz, Michael

    2017-09-01

    The effect of lixisenatide-a prandial once-daily glucagon-like peptide-1 receptor agonist-on glycaemic control in patients with inadequately controlled type 2 diabetes mellitus (T2DM), stratified by baseline β-cell function, was assessed. The 24-week GetGoal-M, -P and -S trials evaluated the efficacy and safety of lixisenatide in combination with oral antidiabetic agents. This post hoc analysis used data from patients receiving lixisenatide in these trials, divided into matched cohorts by propensity scoring, and stratified according to baseline homeostasis model assessment of β-cell function (HOMA-β) index levels, high HOMA-β: > median HOMA-β (28.49%); low HOMA-β: ≤ median. The matched "low" and "high" HOMA-β index cohorts (N = 546 patients) had comparable baseline parameters. Mean change from baseline in glycated haemoglobin (HbA 1c ) was -0.85% and -0.94% for low and high HOMA-β cohorts, respectively (P = .2607). Reductions from baseline in fasting plasma glucose (FPG; -0.77 vs -1.04 mmol/L; P = .1496) and postprandial plasma glucose (PPG; -5.82 vs -5.61 mmol/L; P = .7511) were similar in the low versus high HOMA-β index cohorts. Reduction in body weight was significantly greater in the low versus high HOMA-β index cohort (-2.06 vs -1.13 kg, respectively; P = .0006). In patients with T2DM, lixisenatide was associated with reduction in HbA 1c and improvements in both FPG and PPG, regardless of β-cell function, indicating that lixisenatide is effective in reducing hyperglycaemia, even in patients with more advanced stages of T2DM and poor residual β-cell function. © 2017 The Authors. Diabetes/Metabolism Research and Reviews Published by John Wiley & Sons, Ltd.

  14. Waist-to-height ratio: an accurate anthropometric index of abdominal adiposity and a predictor of high HOMA-IR values in nondialyzed chronic kidney disease patients.

    Science.gov (United States)

    Silva, Maria Inês Barreto; Lemos, Carla Cavalheiro da Silva; Torres, Márcia Regina Simas Gonçalves; Bregman, Rachel

    2014-03-01

    Chronic kidney disease (CKD) is associated with metabolic disorders, including insulin resistance (IR), mainly when associated with obesity and characterized by high abdominal adiposity (AbAd). Anthropometric measures are recommended for assessing AbAd in clinical settings, but their accuracies need to be evaluated. The aim of this study was to evaluate the precision of different anthropometric measures of AbAd in patients with CKD. We also sought to determine the AbAd association with high homeostasis model assessment index of insulin resistance (HOMA-IR) values and the cutoff point for AbAd index to predict high HOMA-IR values. A subset of clinically stable nondialyzed patients with CKD followed at a multidisciplinary outpatient clinic was enrolled in this cross-sectional study. The accuracy of the following anthropometric indices: waist circumference, waist-to-hip ratio, conicity index and waist-to-height ratio (WheiR) to assess AbAd, was evaluated using trunk fat, by dual x-ray absorptiometry (DXA), as a reference method. HOMA-IR was estimated to stratify patients in high and low HOMA-IR groups. The total area under the receiver-operating characteristic curves (AUC-ROC; sensitivity/specificity) was calculated: AbAd with high HOMA-IR values (95% confidence interval [CI]). We studied 134 patients (55% males; 54% overweight/obese, body mass index ≥ 25 kg/m(2), age 64.9 ± 12.5 y, estimated glomerular filtration rate 29.0 ± 12.7 mL/min). Among studied AbAd indices, WheiR was the only one to show correlation with DXA trunk fat after adjusting for confounders (P HOMA-IR values (r = 0.47; P HOMA-IR values was 0.55 (AUC-ROC = 0.69 ± 0.05; 95% CI, 0.60-0.77; sensitivity/specificity, 68.9/61.9). WheiR is recommended as an effective and precise anthropometric index to assess AbAd and to predict high HOMA-IR values in nondialyzed patients with CKD. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Postprandial Triglyceride Is Associated with Fasting Triglyceride and HOMA-IR in Korean Subjects with Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Seo Hee Lee

    2011-08-01

    Full Text Available BackgroundRecent studies indicate postprandial triglyceride (TG had a better association with cardiovascular events and metabolic syndrome than fasting TG. The authors of the present study investigated the metabolic and clinical relevance of postprandial TG.MethodsIn a cross-sectional retrospective study, the authors of the present study compared fasting and postprandial TG and analyzed the relationship between postprandial TG and various demographic and metabolic parameters in 639 Korean subjects with type 2 diabetes (T2D, group I, n=539 and impaired fasting glucose (IFG, group II, n=100 after ingestion of a standardized liquid meal (total 500 kcal, 17.5 g fat, 68.5 g carbohydrate, and 17.5 g protein.ResultsFasting and postprandial TG were significantly correlated (r=0.973, r=0.937, P<0.001 in group I and II, respectively. Of the variables, total cholesterol, waist circumference and body mass index were significantly correlated with fasting and postprandial TG in both groups. Only postprandial TG showed a significant correlation with glucose metabolic parameters (e.g., postprandial glucose, homeostatic model assessment of insulin resistance [HOMA-IR], and fasting C-peptide in subjects with T2D. Multiple regression analysis showed fasting TG and HOMA-IR could be predictable variables for postprandial TG in subjects with T2D.ConclusionPostprandial TG was very strongly correlated with fasting TG. The authors of the present study suggest insulin resistance may be more associated with postprandial TG than fasting TG in Korean T2D patients on a low-fat diet.

  16. La asignatura virtual: Fundamentos de Cirugía en Internet

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    Felip Pi

    Full Text Available Introducción: Internet permite desarrollar un nuevo modelo de clase teórica basado en la enseñanza nopresencial y asincrónica. Objetivo: Publicación virtual de un tema de "Fundamentos de Cirugía" y evaluación de los resultados de uso y participación de los 80 alumnos matriculados. Material y Métodos: Se diseñaron tres partes: teoría, cuestionario de autoevaluación, y foro de preguntas. La teoría consistía en hipertexto y gráficos, con cuatro tipos de asistentes de aprendizaje: 1 remarcadores de información esencial; 2 información no esencial adicional; 3 mnemotécnicos; 4 ampliación conceptos complejos. El cuestionario consistía en diez preguntas. La pantalla de respuesta ofrecía las respuestas correctas comentadas, la puntuación del alumno, y los centiles de cada nota. El foro de preguntas se basaba en el servidor Ez-Board. El profesor sólo explicó el sistema y los aspectos principales de la lección. Los alumnos podían consultar el material indefinidamente y el foro de preguntas estuvo activo durante dos meses. Resultados: El sistema facilitó la clase por parte del profesor y fue muy bien recibida por los alumnos. Se contabilizaron 239 visitas en dos meses, originadas en la Universidad en 80% de los casos. 16 alumnos usaron el asistente interactivo explicativo. El cuestionario fue respondido por 52 alumnos: 36 alumnos 1 vez y 16 alumnos 2 o más veces. El foro recibió 337 visitas. Se hicieron 38 preguntas de alumnos y 46 respuestas del profesor y otros especialistas. Conclusiones: 1 Diseño y funcionamiento correcto; 2 Excelente acogida y participación; 3 Probable mejora en el aprendizaje y adquisición de conocimientos.

  17. La fe de Jesús, fundamento de la fe en Cristo

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    Jorge Costadoat

    2007-01-01

    Full Text Available Lo que la Iglesia cree de Cristo, hunde sus raíces en el modo que tuvo Jesús de creer en Dios. Pero, a la vez, la fe de la Iglesia permite inferir cómo ha podido ser la experiencia espiritual de Jesús. Esta referencia recíproca entre Cristo y la Iglesia invita a indagar en los en los fundamentos antropológicos y teológicos de la fe "de" Jesús, en las dificultades y posibilidades que Jesús ha podido tener para creer en su Padre, puesto que así él enseña por qué y cómo han de creer también los hombres. Por esta vía descubrimos que el Padre, al resucitar a Jesús, triunfa sobre el Mysterium iniquitatis y, contra toda sospecha de indiferencia ante el sufrimiento humano que pudiera recaer sobre Él mismo, da pruebas de ser un Dios que merece fe. El Padre merece fe, pero no la merecería si Él no "creyera" también en la humanidad como "creyó" en su Hijo Jesús. Es el amor del Padre que en última instancia produce confianza en Él y entre los hombresWhat the Church believes of Christ finds its roots in Jesus' manner of believing in God. However, at the same time, the faith of the Church allows one to infer how the spiritual experience of Jesus came about. This reciprocal reference between Christ and the Church invites one to investigate the anthropological and theological tenets of the faith "of" Jesus, in the difficulties and possibilities that Jesus could have had in order to believe in his Father, given that he teaches us accordingly why and how to believe as well. In this way we discover that the Father, upon raising up Jesus, triumphs over the Mysterium iniquitatis and, against every suspicion of a possible indifference on the God's part in the face of human suffering, gives proof of being a God who deserves faith. The Father deserves faith, but he wouldn't if He did not also "believe" in humanity, just as He "believed" in his Son, Jesus. It is the love of the Father that, in the final analysis, brings about trust in Him and

  18. Editorial. Fundamentos para una Pedagogía del Saber y del No Saber

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    Agustín de la Herrán Gascón

    2018-03-01

    Full Text Available El libro titulado “Fundamentos para una Pedagogía del Saber y del No Saber” (Herrán Gascón, A. de la, São Paulo: Edições Hipótese, 2018 sirve el propósito de contribuir a la necesaria renovación radical de la Pedagogía y de la Didáctica, para favorecer una educación y una formación más coherentes y completas con base en la conciencia. Se apoya en la tesis de que la herencia de Sócrates es limitante para la educación, y condiciona el constructo ‘formación’ y la evolución de la Pedagogía y de la Didáctica. Hoy ambas disciplinas son parcialmente válidas, porque su base, erigida sobre el aprender, el conocer y sobre una idea parcial de formación, es incompleta. Su énfasis en el saber –léase no sólo aprendizaje de saberes, sino el saber pensar, saber sentir, saber ser, saber convivir, saber hacer, saber gestionar las emociones, saber contenidos instructivos u orientadores, saber competencias, etc. -limita la educación y la formación. No parecen darse cuenta de esta posibilidad, al parecer, los organismos internacionales de educación, las leyes y los sistemas educativos, ni la mayor parte de pedagogos e investigadores de la educación. Históricamente, se ha arrastrado en estas disciplinas un sesgo, al no incorporarse la enseñanza de grandes pedagogos o maestros de la formación de Oriente, con una mirada diferente. Nuestra posición es que sin la comprensión que ofrecen –y que al parecer se ignora por el ‘occidentalismo’ (o ismo de Occidente en que vivimos, potenciado por la globalización,- la educación no puede estar completa, ni puede comprenderse en absoluto.

  19. Fundamentos para una moral natural: la necesidad del naturalismo ético frente al racionalismo axiológico

    OpenAIRE

    Clarke Paliza, George

    2012-01-01

    En esta tesis se discute la validez de los valores morales racionales frente a los valores del mundo natural. Con respecto al antagonismo tradicional entre la moral y la natu-raleza, se presentan los fundamentos para la creación de una moral natural, es decir, una moral cuyas bases axiológicas toman como parámetro a la naturaleza. El carácter histórico y contingente del idealismo moral muestra su insuficiencia para fundar un sistema axiológico fiable que siga el curso de los acontecimientos n...

  20. Entorno educativo para el aprendizaje de fundamentos de electrónica analógica, digital y de potencia

    OpenAIRE

    Áriz Muñoz, Guillermo

    2012-01-01

    El objetivo del presente proyecto es el desarrollo de un cuaderno de prácticas adaptado a la formación que se desea ofrecer en la asignatura “Fundamentos de Electrónica”. Concretamente el proyecto pretende abordar la definición de prácticas de laboratorio que trabajen la capacidad de análisis teórico de circuitos electrónicos y las habilidades necesarias para su montaje y monitorización (manejo de instrumentación de medida, detección de fallos etc. Puesto que se trata del prime...

  1. La reflexividad y la autocrítica como fundamentos de la investigación cualitativa

    OpenAIRE

    de la Cuesta Benjumea, Carmen; Otálvaro Orrego, Jáider Camilo

    2015-01-01

    Se plantean algunas tensiones y retos para la investigación cualitativa en la actualidad, las cuales son consecuencia de las dinámicas que imponen las universidades y las comunidades científicas. La ética de la investigación cualitativa y sus fundamentos se ven cuestionados por los investigadores que, desde otras perspectivas, la ven como fútil e infértil. Entre quienes hacen investigación cualitativa también empiezan a hallarse preguntas sobre la utilidad y la funcionalidad de la investigaci...

  2. A educação em Cuba: seus fundamentos e desafios

    Directory of Open Access Journals (Sweden)

    Margarita Quintero López

    2011-01-01

    Full Text Available O artigo trata da importância da educação para qualquer nação, e para Cuba em particular, com seus fundamentos políticos, pedagógicos e sociológicos, e mostra seu comportamento nos últimos 50 anos. Para isso, são expostos os princípios que sustentam a política educativa do Estado cubano, que dão base ao Sistema Nacional de Educação (SNE, como instrumento para levar adiante a obra educativa do país. Oferece, também, uma caracterização de cada um dos subsistemas que o integram para garantir o cumprimento dos objetivos principais da educação: formar as novas gerações e todo o povo na concepção científica do mundo; desenvolver em toda sua plenitude as capacidades intelectuais, físicas e espirituais; fomentar elevados sentimentos e gostos estéticos; e converter os princípios ideológicos, políticos e morais comunistas em convicções pessoais e hábitos de conduta diária, com a participação da escola, da família e de toda a sociedade. O artigo apresenta, também, as transformações que atualmente se levam adiante no Ministério da Educação com a participação de seus diretores, docentes, estudantes e demais agentes sociais, para continuar trabalhando na elevação da qualidade de seus resultados.Se argumenta la importancia de la educación para cualquier nación y para Cuba en particular, con sus fundamentos políticos, pedagógicos y sociológicos y se muestra su comportamiento en los últimos 50 años. Se exponen los principios que sustentan la política educacional del Estado cubano, que dan base al Sistema Nacional de Educación (SNE, como instrumento para llevar adelante la obra educacional del país. Se ofrece una caracterización de cada uno de los subsistemas que lo integran para garantizar el cumplimiento del objetivo principal de la educación: formar a las nuevas generaciones y a todo el pueblo en la concepción científica del mundo, desarrollar en toda su plenitud las capacidades intelectuales, f

  3. HOMA, BMI, and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic, Nonobese, and Nondiabetic Chronic Hepatitis C Genotype 1 Patients

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    Alessandro Grasso

    2015-01-01

    Full Text Available Objective. To investigate the relationship between insulin resistance and viral load decay in nondiabetic and noncirrhotic genotype 1 chronic HCV patients during peginterferon and ribavirin treatment and the possible influence of BMI and leptin as metabolic confounders. Methods. 75 consecutive noncirrhotic, nonobese, and nondiabetic patients with genotype 1 chronic hepatitis C treated with peginterferon alpha 2a plus ribavirin were evaluated. HOMA-IR, serum leptin, and BMI were measured in all patients at baseline and at weeks 12 and 48, whereas viral load was measured at the same time points and then 24 weeks after the end of treatment. Results. HOMA-IR was significantly associated with both BMI and leptin at baseline. During peginterferon plus ribavirin treatment, there was a significant reduction of HOMA-IR at weeks 12 and 48 from baseline (P=0.033 and 0.048, resp. in patients who achieved an early viral load decay (EVR, a trend not observed in patients who not achieved EVR. No variations during treatment were observed regarding BMI and leptin irrespective of EVR. Conclusion. The early reduction of HOMA-IR but not of BMI and leptin during antiviral treatment in noncirrhotic, chronic hepatitis C genotype 1 patients who achieved EVR suggests a viral genesis of insulin resistance in patients with nonmetabolic phenotype.

  4. HOMA, BMI, and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic, Nonobese, and Nondiabetic Chronic Hepatitis C Genotype 1 Patients.

    Science.gov (United States)

    Grasso, Alessandro; Malfatti, Federica; Andraghetti, Gabriella; Marenco, Simona; Mazzucchelli, Chiara; Labanca, Sara; Cordera, Renzo; Testa, Roberto; Picciotto, Antonino

    2015-01-01

    Objective. To investigate the relationship between insulin resistance and viral load decay in nondiabetic and noncirrhotic genotype 1 chronic HCV patients during peginterferon and ribavirin treatment and the possible influence of BMI and leptin as metabolic confounders. Methods. 75 consecutive noncirrhotic, nonobese, and nondiabetic patients with genotype 1 chronic hepatitis C treated with peginterferon alpha 2a plus ribavirin were evaluated. HOMA-IR, serum leptin, and BMI were measured in all patients at baseline and at weeks 12 and 48, whereas viral load was measured at the same time points and then 24 weeks after the end of treatment. Results. HOMA-IR was significantly associated with both BMI and leptin at baseline. During peginterferon plus ribavirin treatment, there was a significant reduction of HOMA-IR at weeks 12 and 48 from baseline (P = 0.033 and 0.048, resp.) in patients who achieved an early viral load decay (EVR), a trend not observed in patients who not achieved EVR. No variations during treatment were observed regarding BMI and leptin irrespective of EVR. Conclusion. The early reduction of HOMA-IR but not of BMI and leptin during antiviral treatment in noncirrhotic, chronic hepatitis C genotype 1 patients who achieved EVR suggests a viral genesis of insulin resistance in patients with nonmetabolic phenotype.

  5. Homeostatic model assessment for insulin resistance (homa-ir): a better marker for evaluating insulin resistance than fasting insulin in women with polycystic ovarian syndrome

    International Nuclear Information System (INIS)

    Majid, H.; Khan, A.H.; Masood, Q.

    2017-01-01

    To assess the utility of HOMA-IR in assessing insulin resistance in patients with polycystic ovary syndrome (PCOS) and compare it with fasting insulin for assessing insulin resistance (IR). Study Design: Observational study. Place and Duration of Study: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from January 2009 to September 2012. Methodology: Medical chart review of all women diagnosed with PCOS was performed. Of the 400 PCOS women reviewed, 91 met the inclusion criteria. Insulin resistance was assessed by calculating HOMA-IR using the formula (fasting glucose x fasting insulin)/405, taking normal value =12 micro IU/ml. Results: A total of 91 premenopausal women diagnosed with PCOS were included. Mean age was 30 +-5.5 years. Mean HOMA-IR of women was 3.1 +-1.7, respectively with IR in 69% (n=63) women, while hyperinsulinemia was present in 60% (n=55) women (fasting Insulin 18.5 +-5.8 micro IU/ml). Hyperandrogenism was present in 53.8% (n=49), whereas 38.5% (n=35) women had primary infertility or subfertility, while 65.9% (n=60) had menstrual irregularities; and higher frequencies were observed in women with IR. Eight subjects with IR and endocrine abnormalities were missed by fasting insulin. Conclusion: Insulin resistance is common in PCOS and it is likely a pathogenic factor for development of PCOS. HOMA-IR model performed better than hyperinsulinemia alone for diagnosing IR. (author)

  6. Fundamentos epistemológicos para un modelo psico-pedagógico en educación sexual

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    Henry de Jesús Gallardo Pérez

    2018-01-01

    Full Text Available La investigación pretende generar algunos fundamentos epistemológicos como base para la construcción teórica de un modelo psico-pedagógico en educación sexual dirigido a los adolescentes. Se realizó bajo el paradigma cualitativo enmarcada en los métodos fenomenológicos - hermenéuticos apoyado en el estudio de casos; es significativo señalar que en primer lugar se efectuó un estudio piloto de corte cuantitativo; el cual permitió evidenciar las categorías a tratar en la parte del análisis de información. Las categorías como abuso sexual, consumo de sustancias psicoactivas, embarazo a temprana edad, enfermedades de transmisión sexual, pornografía, cibersexo y sexting, dejan entrever que es pertinente implementar los fundamentos epistemológicos para la enseñanza de la educación sexual en las instituciones lo que conlleva a que la sociedad alcance un bienestar social acorde con las exigencias mínimas que garanticen la subsistencia del hombre.

  7. As políticas sociais nos fundamentos dos projetos pedagógicos dos cursos de Psicologia

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    Pablo Sousa Seixas

    Full Text Available Resumo A Psicologia aproximou-se das políticas sociais, evocando mudanças para a atuação e formação nesse campo. O objetivo deste artigo é investigar o lugar que as políticas sociais ocupam nos fundamentos teórico-político dos Projetos Pedagógicos dos Cursos (PPCs de graduação em Psicologia no Brasil. Foram analisados 40 PPCs de instituições públicas e privadas das cinco regiões do Brasil. Analisaram-se os trechos sobre políticas sociais localizados nos textos do PPC relativos a: a os fundamentos do curso e b a descrição das práticas profissionais (composta pelas ênfases curriculares e locais de atuação indicados. Como resultados, identificou-se que ao tratarem das políticas sociais, os cursos possuem um foco técnico e prático, preocupando-se, recorrentemente, com a promoção de saúde e compromisso social - configuração identificada nas duas dimensões analisadas. Merece atenção a definição limitada dos dois últimos conceitos, corroborando com a indicação da literatura sobre as restrições do seu uso para direcionar as políticas sociais.

  8. La pedagogía de proyectos en la escuela: una revisión de sus fundamentos filosóficos y psicológicos

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    Nylza Offir García-Vera

    2012-01-01

    Full Text Available El artículo de reflexión derivado de la investigación La pedagogía de proyectos en la escuela: una revisión de sus fundamentos filosóficos y psicológicos, presenta un análisis global del enfoque denominado hoy Pedagogía de Proyectos, desde un recorrido histórico y epistemológico que intenta dar cuenta de sus orígenes y fundamentos teóricos constitutivos desde la filosofía con el pragmatismo, desde la psicología con el constructivismo, aplicados o recontextualizados en el campo educativo y pedagógico. Lo anterior en la perspectiva de señalar algunos puntos críticos derivados de tales fundamentos y de avizorar las posibles implicaciones para la cultura escolar.

  9. Meta-analyses of the Association of Sleep Apnea with Insulin Resistance, and the Effects of CPAP on HOMA-IR, Adiponectin, and Visceral Adipose Fat.

    Science.gov (United States)

    Iftikhar, Imran H; Hoyos, Camilla M; Phillips, Craig L; Magalang, Ulysses J

    2015-04-15

    We sought to conduct an updated meta-analysis of randomized controlled trials (RCTs) on the effect of continuous positive airway pressure (CPAP) on insulin resistance, as measured by homeostasis model assessment of insulin resistance (HOMA-IR), visceral abdominal fat (VAF), and adiponectin. Additionally, we performed a separate meta-analysis and meta-regression of studies on the association of insulin resistance and obstructive sleep apnea (OSA). All included studies were searched from PubMed (from conception to March 15, 2014). Data were pooled across all included RCTs as the mean difference in HOMA-IR and VAF, and as the standardized mean difference in the case of adiponectin analysis. From the included case-control studies, data on the difference of HOMA-IR between cases and controls were pooled across all studies, as the standardized mean difference (SMD). There was a significant difference in HOMA-IR (-0.43 [95% CIs: -0.75 to -0.11], p = 0.008) between CPAP treated and non CPAP treated participants. However, there was no significant difference in VAF or adiponectin; (-47.93 [95% CI: -112.58 to 16.72], p = 0.14) and (-0.06 [95% CI: -0.28 to 0.15], p = 0.56), respectively. Meta-analysis of 16 case-control studies showed a pooled SMD in HOMA-IR of 0.51 (95% CI: 0.28 to 0.75), p ≤ 0.001, between cases and controls. The results of our meta-analyses show that CPAP has a favorable effect on insulin resistance. This effect is not associated with any significant changes in total adiponectin levels or amount of VAF. Our findings also confirm a significant association between OSA and insulin resistance. © 2015 American Academy of Sleep Medicine.

  10. The contribution of SHBG to the variation in HOMA-IR is not dependent on endogenous oestrogen or androgen levels in postmenopausal women.

    Science.gov (United States)

    Davis, Susan R; Robinson, Penelope J; Moufarege, Alain; Bell, Robin J

    2012-10-01

    Sex hormone-binding globulin (SHBG) is a robust predictor of insulin resistance. Whether this is independent of circulating sex steroid levels remains uncertain. The aim of this study was to investigate the determinants of SHBG in postmenopausal women and whether the relationship between SHBG and insulin resistance is independent of oestrogen and androgen levels. A cross-sectional study of naturally and surgically menopausal women. Seven hundred and sixty three postmenopausal women not using any systemic hormone therapy, mean age 54·4 ± 5·8 years, recruited in the US, Canada, Australia, UK and Sweden between July 2004 and February 2005. Relationships between log-transformed (ln) SHBG and ln homoeostasis model assessment for insulin resistance (HOMA-IR) were explored, taking into account age, body mass index (BMI), blood pressure (BP) and circulating oestradiol, oestrone, testosterone and dihydrotestosterone. Taking into account age, race, years since menopause, menopause type, BMI, BP, prior postmenopausal hormone use and the sex steroids measured, 34·4% of the variation in SHBG could be explained by the model that included negative contributions by HOMA-IR, BMI and diastolic BP, and a positive contribution by total testosterone (P HOMA-IR, which was best explained by the model that included BMI, SHBG, systolic BP and surgical menopause, with each variable being positively related to HOMA-IR (r(2) = 0·3152, P = 0·03). The relationship between SHBG and HOMA-IR, as an estimate of insulin resistance, is not explained by endogenous oestrogen and androgen levels and is, at least in part, independent of BMI in postmenopausal women. © 2011 Blackwell Publishing Ltd.

  11. Optimal cutoff points for HOMA-IR and QUICKI in the diagnosis of metabolic syndrome and non-alcoholic fatty liver disease: A population based study.

    Science.gov (United States)

    Motamed, Nima; Miresmail, Seyed Javad Haji; Rabiee, Behnam; Keyvani, Hossein; Farahani, Behzad; Maadi, Mansooreh; Zamani, Farhad

    2016-03-01

    The present study was carried out to determine the optimal cutoff points for homeostatic model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) in the diagnosis of metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD). The baseline data of 5511 subjects aged ≥18years of a cohort study in northern Iran were utilized to analyze. Receiver operating characteristic (ROC) analysis was conducted to determine the discriminatory capability of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. Youden index was utilized to determine the optimal cutoff points of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. The optimal cutoff points for HOMA-IR in the diagnosis of MetS and NAFLD were 2.0 [sensitivity=64.4%, specificity=66.8%] and 1.79 [sensitivity=66.2%, specificity=62.2%] in men and were 2.5 [sensitivity=57.6%, specificity=67.9%] and 1.95 [sensitivity=65.1%, specificity=54.7%] in women respectively. Furthermore, the optimal cutoff points for QUICKI in the diagnosis of MetS and NAFLD were 0.343 [sensitivity=63.7%, specificity=67.8%] and 0.347 [sensitivity=62.9%, specificity=65.0%] in men and were 0.331 [sensitivity=55.7%, specificity=70.7%] and 0.333 [sensitivity=53.2%, specificity=67.7%] in women respectively. Not only the optimal cutoff points of HOMA-IR and QUICKI were different for MetS and NAFLD, but also different cutoff points were obtained for men and women for each of these two conditions. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Can phytoliths and lipid biomarkers constrain and refine isotopic palaeoclimatic reconstructions? Insights from the Homa Peninsula, western Kenya

    Science.gov (United States)

    Vincent, Thomas; Whitfield, Elizabeth; Bishop, Laura; Plummer, Thomas; Ditchfield, Peter; Blumenthal, Scott; Finestone, Emma; Kiriakoulakis, Kostas

    2017-04-01

    Several archaeological sites on the Homa Peninsula, western Kenya, host Plio-Pleistocene sedimentary sequences that contain hominin archaeological traces and faunal remains. As a result, the region preserves rare palaeoanthropological information of a crucial time period in East Africa. By reconstructing the palaeoenvironmental substrate here, a deeper understanding of hominin activities and behaviour in variable landscapes will be gained. This is the aim of the current research, which utilises a multiproxy approach to reconstruct the palaeoenvironment, encompassing analyses of particle size, phytoliths and lipid biomarkers. Previous work at the most extensively studied site on the peninsula, Kanjera South, has shown sediments containing archaeological occurrences to be ca. 2 Ma in age. Reconstructions of the palaeoenvironment here have largely been based on field investigations and isotopic analysis of pedogenic/palaeosol carbonates and tooth enamel, which revealed clear evidence of a grassland setting (>75% C4 vegetation). However, in order to form robust and reliable reconstructions of palaeoclimate, information derived from a single proxy is insufficient. For example, the prolonged and seasonally biased formation of pedogenic carbonates can mask seasonal fluctuations in vegetation, causing variable environmental settings to be overlooked when using isotope data from this source. Soil organic matter offers another source of isotope data, however 13C enrichment from plant carbon may also introduce uncertainty here. Resultantly, due to the significance of the site, it is essential that reconstructions of the palaeoclimate, palaeovegetation and palaeoenvironment as a whole are robust and reliable, and so multiproxy evidence is essential. Here, we present the use of phytoliths and lipid biomarkers to provide further insights into the C3/C4 vegetation distribution on the peninsula, and consequently act as proxies for palaeoclimate and palaeovegetation. Both

  13. Fundamentos teórico-económicos de la gestión del conocimiento / Fundamentos teórico-econômicos da gestão do conhecimento

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    Mónica Sánchez Limón

    2005-12-01

    Full Text Available El trabajo pretende examinar, algunas de las principales contribuciones de la teoría económica a la formación de un marco conceptual de la Gestión de Conocimiento. En el trabajo se revisan los aportes de algunos economistas neoclásicos y evolucionistas que desde los años 80 han ido desarrollando toda una concepción sobre la Economía basada en el Conocimiento y a través de ella, han descubierto las bases teóricas conceptuales que están en los fundamentos de la gestión de conocimiento.

  14. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin: A Prospective Cohort Study.

    Science.gov (United States)

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying

    2016-02-01

    This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels.A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index.After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend HOMA-IR index in the entire cohort, men, and women were 1.33 (1.10-1.62), 1.46 (1.08-1.98), and 1.47 (1.12-1.91), respectively. The combination of sleep deprivation with no naps or >30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24-3.51; HR = 4.00, 95% CI = 2.03-7.90; and HR = 2.05, 95% CI = 1.29-3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48-3.02; and HR = 1.35, 95% CI = 1.10-1.65, respectively).Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with brief daytime napping HOMA-IR index.

  15. Índices HOMA1-IR e HOMA2-IR para identificação de resistência à insulina e síndrome metabólica: Estudo Brasileiro de Síndrome Metabólica (BRAMS)

    OpenAIRE

    Geloneze, Bruno; Vasques, Ana Carolina Junqueira; Stabe, Christiane França Camargo; Pareja, José Carlos; Rosado, Lina Enriqueta Frandsen Paez de Lima; Queiroz, Elaine Cristina de; Tambascia, Marcos Antonio

    2009-01-01

    OBJECTIVE: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. METHODS: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. RESULTS: In the he...

  16. Determinación del índice de resistencia a la insulina mediante homa y su relación con el riesgo de hipertensión inducida por el embarazo Insulin resistance index assessment by homa and its relation with the risk of pregnancy induced hypertension

    Directory of Open Access Journals (Sweden)

    Jesús Sierra-Laguado

    Full Text Available Objetivo: investigar si el grado de resistencia a la insulina determinado por el índice HOMA, predice de manera temprana el desarrollo de hipertensión inducida por el embarazo en gestantes colombianas. Diseño-métodos: se realizó un estudio de casos y controles anidado en una cohorte prospectiva de 438 mujeres primigestantes, normotensas y con edad gestacional menor de 30 semanas. Se determinó el índice HOMA a partir de la medición de glucemia e insulina plasmática en ayunas, por métodos de glucosa oxidasa y quimioluminiscencia, respectivamente. Resultados: veintitrés mujeres desarrollaron hipertensión inducida por el embarazo (5,25%. Se seleccionaron de forma aleatoria dos embarazadas normotensas como controles por cada caso, pareadas por edad materna y gestacional al momento de su inclusión. Las mujeres que posteriormente desarrollaron hipertensión inducida por el embarazo presentaron mayores niveles de HOMA (1,48 ± 0,98 vs. 0,96 ± 0,70, pObjective: to assess whether insulin resistance determined by homeostatic model assessment (HOMA is an early predictor of the development of pregnancy induced hypertension in Colombian pregnant women. Methods: we conducted a nested case control study in a prospective cohort of four hundred and thirty eigth normotensive primigravidae women, with gestational age < 30 weeks. The HOMA was calculated using fasting plasma concentrations of glucose and insulin, determined by glucose-oxidase and chemoluminiscence methods, respectively. Results: twenty-three pregnant women developed pregnancy induced hypertension (5.25%. Two normotensive pregnant women were selected as controls for each case, matched by gestational and maternal age at enrollment. The women who subsequently developed pregnancy induced hypertension had higher levels of HOMA (1.48 ± 0.98 vs 0.96 ± 0.70, p<0.001, which was associated with an increased risk of developing pregnancy induced hypertension (OR: 3.8, IC95%: 1.1-12.8 p=0

  17. A Dialética do Senhor e do Escravo como Fundamento da Sociologia enquanto Ciência Humana

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    Henrique Raskin

    2016-12-01

    Full Text Available O presente artigo busca derivar, a partir da Dialética do Senhor e do Escravo, da Fenomenologia do Espírito de Hegel, a sociologia moderna enquanto ciência essencialmente humana. Assim, a partir do conceito de intersubjetividade que Hegel desenvolve através de sua filosofia do espírito, pretende-se analisar os fundamentos filosóficos dos pensamentos sociológicos de Karl Marx e de Max Weber. Conclui-se, portanto, que tanto o viés revolucionário do Manifesto Comunista, quanto o viés conservador da Ética Protestante, partem, fundamentalmente, do legado filosófico hegeliano.

  18. El fundamento de los principios jurídicos: una cuestión problemática

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    Jose Julián Suarez Rodriguez

    2016-01-01

    Full Text Available El presente artículo tiene por objeto hacer un análisis de la influencia que la categoría normativa de los principios jurídicos ha tenido en el derecho constitucional colombiano y la manera como ha transformado la teoría y la práctica del derecho constitucional contemporáneo. Además, se plantea una cuestión olvidada en la teoría contemporánea de los principios jurídicos: el fundamento último de la fuerza normativa de los principios. Así, se ofrece como respuesta final, apenas entrevista, que la dignidad humana constituye el cimiento de las exigencias iusconstitucionales contenidas en los principios jurídicos

  19. DIÁLOGO SOBRE OS FUNDAMENTOS DA EDUCAÇÃO: RECORTES E DISCUSSÕES, VOL. V

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    Eliane Pimentel Camillo Barra Nova de Melo

    2016-02-01

    Full Text Available A coleção Fundamentos da Educação: Recortes e Discussões chega ao seu quinto volume todos publicados pela Paco Editorial. O presente volume foi lançado em 2015 e contem 406 páginas, escritas por 21 autores, dentre eles graduados, especialistas, mestrandos, mestres, doutorandos, doutores, pós-doutores, todos estudiosos do campo educacional e comprometidos em compreender melhor tal fenômeno. Para isso buscaram, nesta obra, desvendar o pensamento pedagógico dos seguintes estudiosos: Charles Darwin, Herbert Spencer, Édouard Claparède, Adolphe Ferrière, Henri Wallon, Roger Cousinet, Alexander Luria, Alexei Leontiev, Ana Teberosky, Emília Ferreiro, Howard Gardner, Hannah Arendt, Augusto Comte, Émile Durkheim, B.F. Skinner, Lawrence Stenhouse, Anton Makarenko, Florestan Fernandes, Louis Althusser e Michel Foucault.

  20. La actitud de escucha, fundamento de la comunicación y la democracia en el aula

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    J. HUMBERTO MOTTA ÁVILA

    2017-01-01

    Full Text Available El artículo busca dar cuenta de la actitud de escucha de estudiantes y docentes como fundamento de la comunicación y la democracia en el aula de clases. Presenta una síntesis del diagnóstico actual de la escucha áulica, y los referentes teóricos que sustentan la relación escucha-comunicación-democracia. El proceso metodológico está basado en las tradiciones fenomenológica y hermenéutico-reflexiva. Como resultado, se explica que el acto de escucha es condición indispensable del acto pedagógico de aula, que la escucha ha devenido en disonancia y déficit de la democracia y en la esencia de la conversación democrática.

  1. Estudio de algunos problemas de fundamento de la teoría axiomática de conjuntos

    OpenAIRE

    Vahí Serrano, Ángel

    1992-01-01

    Desde su nacimiento, la teoría de conjuntos ha tenido detractores y críticos. En la ensalada filosófica que se aliñó durante la crisis de fundamento sufrida por las matemáticas a causa de las paradojas, entre otras las descubiertas en el seno de la teoría de conjuntos, hubo de todo, sin faltar la opinión de que dicha situación no era s ... ino una consecuencia de los abstrusos y quiméricos contenidos de dicha teoría. A lo largo de cien años, esa postura ha persistido entre determinadas matemá...

  2. Reseña: Fundamentos de la eficacia publicitaria y retorno de la inversión

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    Francisco Cabezuelo Lorenzo

    2014-02-01

    Full Text Available Sin duda alguna, la aparición de un nuevo libro en el ámbito de la Ciencias de la Comunicación es siempre una muy buena noticia. En este caso, la noticia es tres veces buena, como sus tres autores. El pasado 2012 apareció en el mercado editorial el libro de Fernando Rodríguez Varona, Carmen Llorente Barroso y María Luisa García Guardia, titulado “Fundamentos de la eficacia publicitaria y el retorno de la inversión”, un volumen de 218 páginas editado por Delta Publicaciones. Se trata de un trabajo muy completo, interesante, ameno, didáctico y riguroso en el que los tres coautores profundizan en la medición de la eficacia de las campañas publicitarias.

  3. GESTIÓN DEL CONOCIMIENTO Y DESARROLLO AGRARIO: FUNDAMENTOS TEÓRICOS PARA UN ESTUDIO DE CASO (PARTE 1

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    Olmes Eliecer García Bode

    2013-08-01

    Full Text Available Este trabajo incluye un análisis de los fundamentos teóricos para la Gestión del Conocimiento en el contexto agrícola. En él se explica la necesidad de utilizar las competencias existentes en las organizaciones agropecuarias para la aplicación eficiente de la tecnología en las condiciones de la región. Se hace hincapié en la importancia de orientar los esfuerzos para hacer un uso más eficaz del capital intelectual. Utilizando las definiciones analizadas se obtuvieron como componentes esenciales: el sistema estratégico, el contexto organizacional, el capital disponible intelectual, los procesos de creación y el crecimiento del aprendizaje organizacional y el conocimiento y la cultura organizacional, y la lógica de la acción transformadora.

  4. Schwember Augier, F., Libertad, derecho y propiedad. El fundamento de la propiedad en la filosofía del derecho de Kant y Fichte [Reseña

    OpenAIRE

    Acosta, E. (Emiliano)

    2015-01-01

    Reseña de la obra de Schwember Augier, Felipe, Libertad, derecho y propiedad. El fundamento de la propiedad en la filosofía del derecho de Kant y Fichte, Olms, Hildesheim/Zürich/New York, 2013, 425 pp.

  5. BMI, HOMA-IR, and Fasting Blood Glucose Are Significant Predictors of Peripheral Nerve Dysfunction in Adult Overweight and Obese Nondiabetic Nepalese Individuals: A Study from Central Nepal.

    Science.gov (United States)

    Thapa, Lekhjung; Rana, P V S

    2016-01-01

    Objective. Nondiabetic obese individuals have subclinical involvement of peripheral nerves. We report the factors predicting peripheral nerve function in overweight and obese nondiabetic Nepalese individuals. Methodology. In this cross-sectional study, we included 50 adult overweight and obese nondiabetic volunteers without features of peripheral neuropathy and 50 healthy volunteers to determine the normative nerve conduction data. In cases of abnormal function, the study population was classified on the basis of the number of nerves involved, namely, "HOMA-IR) was the significant predictor (P = 0.019, 96% CI = 1.420-49.322) of sensory nerve dysfunction. Body mass index (BMI) was the significant predictor (P = 0.034, 95% CI = 1.018-1.577) in case of ≥2 mixed nerves' involvement. Conclusion. FBG, HOMA-IR, and BMI were significant predictors of peripheral nerve dysfunction in overweight and obese Nepalese individuals.

  6. Índice HOMA-Adiponectina como marcador substitutivo de resistência à insulina : Estudo Brasileiro de Síndrome Metabólica (BRAMS)

    OpenAIRE

    Brunna Sullara Vilela Rodrigues

    2016-01-01

    Resumo: Introdução: As principais consequências da obesidade estão diretamente relacionadas ao desenvolvimento da resistência à insulina (RI), especialmente a síndrome metabólica (SM) caracterizada como um conjunto de fatores de risco cardiovascular em um mesmo indivíduo. O índice HOMA-AD foi proposto recentemente como um método substitutivo de avaliação da resistência à insulina. Este método é uma modificação do índice HOMA-IR que acrescenta a informação de adiponectina sérica ao seu denomin...

  7. HOMA-IR is associated with significant angiographic coronary artery disease in non-diabetic, non-obese individuals: a cross-sectional study.

    Science.gov (United States)

    Mossmann, Márcio; Wainstein, Marco V; Gonçalves, Sandro C; Wainstein, Rodrigo V; Gravina, Gabriela L; Sangalli, Marlei; Veadrigo, Francine; Matte, Roselene; Reich, Rejane; Costa, Fernanda G; Bertoluci, Marcello C

    2015-01-01

    Insulin resistance is a major component of metabolic syndrome, type 2 Diabetes Mellitus (T2DM) and coronary artery disease (CAD). Although important in T2DM, its role as a predictor of CAD in non-diabetic patients is less studied. In the present study, we aimed to evaluate the association of HOMA-IR with significant CAD, determined by coronary angiography in non-obese, non-T2DM patients. We also evaluate the association between 3 oral glucose tolerance test (OGTT) based insulin sensitivity indexes (Matsuda, STUMVOLL-ISI and OGIS) and CAD. We conducted a cross-sectional study with 54 non-obese, non-diabetic individuals referred for coronary angiography due to suspected CAD. CAD was classified as the "anatomic burden score" corresponding to any stenosis equal or larger than 50 % in diameter on the coronary distribution. Patients without lesions were included in No-CAD group. Patients with at least 1 lesion were included in the CAD group. A 75 g oral glucose tolerance test (OGTT) with measurements of plasma glucose and serum insulin at 0, 30, 60, 90 and 120 min was obtained to calculate insulin sensitivity parameters. HOMA-IR results were ranked and patients were also categorized into insulin resistant (IR) or non-insulin resistant (NIR) if they were respectively above or below the 75th percentile (HOMA-IR > 4.21). The insulin sensitivity tests results were also divided into IR and NIR, respectively below and above each 25th percentile. Chi square was used to study association. Poisson Regression Model was used to compare prevalence ratios between categorized CAD and IR groups. Fifty-four patients were included in the study. There were 26 patients (48 %) with significant CAD. The presence of clinically significant CAD was significant associated with HOMA-IR above p75 (Chi square 4.103, p = 0.0428) and 71 % of patients with HOMA-IR above p75 had significant CAD. Subjects with CAD had increased prevalence ratio of HOMA-IR above p75 compared to subjects without

  8. Estimation of insulin resistance in non-diabetic normotensive Saudi adults by QUICKI, HOMA-IR and modified QUICKI: a comparative study.

    Science.gov (United States)

    Bahijri, Suhad M; Alissa, Eman M; Akbar, Daad H; Ghabrah, Tawfik M

    2010-01-01

    Identification of insulin resistance (IR) in the general population is important for developing strategies to reduce the prevalence of non-insulin-dependent diabetes mellitus (NIDDM). We used the original and a modified version of the Quantitative Insulin Sensitivity Check Index (QUICKI, M-QUICKI), and the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to divide non-diabetic normotensive adults into high- (HIR) and low-insulin-resistant (LIR) subgroups to investigate similarities and differences in their characteristics. Three hundred fifty-seven healthy adults aged 18-50 years were recruited randomly from health centers in Jeddah in a cross-sectional study design. Anthropometric and demographic information was taken. Insulin, glucose, lipid profile and free fatty acid were determined in fasting blood samples. M-QUICKI, HOMA-IR and QUICKI were calculated. Reported cut-off points were used to identify HIR subjects, who were then matched for age and sex to others in the study population, resulting in 3 HIR and 3 LIR subgroups. Two hundred nine subjects satisfied the selection criteria. M-QUICKI correlated significantly (P=.01) with HOMA-IR and QUICKI values. Increased adiposity was the common characteristic of the three HIR subgroups. HIR subgroups identified using M-QUICKI (97 subjects) and HOMA (25 subjects), but not QUICKI (135 subjects), had statistically different biochemical characteristics compared to corresponding LIR sub-groups. Adiposity, but not sex, is a risk factor for IR in the studied population. Further studies are needed to choose the most appropriate index for detecting IR in community-based surveys.

  9. A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate.

    Science.gov (United States)

    Piyathilake, Chandrika J; Badiga, Suguna; Alvarez, Ronald D; Partridge, Edward E; Johanning, Gary L

    2013-01-01

    Identification of associations between global DNA methylation and excess body weight (EBW) and related diseases and their modifying factors are an unmet research need that may lead to decreasing DNA methylation-associated disease risks in humans. The purpose of the current study was to evaluate the following; 1) Association between the degree of peripheral blood mononuclear cell (PBMC) L1 methylation and folate, and indicators of EBW, 2) Association between the degree of PBMC L1 methylation and folate, and insulin resistance (IR) as indicated by a higher homeostasis model assessment (HOMA-IR). The study population consisted of 470 child-bearing age women diagnosed with abnormal pap. The degree of PBMC L1 methylation was assessed by pyrosequencing. Logistic regression models specified indicators of EBW (body mass index-BMI, body fat-BF and waist circumference-WC) or HOMA-IR as dependent variables and the degree of PBMC L1 methylation and circulating concentrations of folate as the independent predictor of primary interest. Women with a lower degree of PBMC L1 methylation and lower plasma folate concentrations were significantly more likely to have higher BMI, % BF or WC (OR = 2.49, 95% CI:1.41-4.47, P = 0.002; OR = 2.49, 95% CI:1.40-4.51, P = 0.002 and OR = 1.98, 95% = 1.14-3.48 P = 0.0145, respectively) and higher HOMA-IR (OR = 1.78, 95% CI:1.02-3.13, P = 0.041). Our results demonstrated that a lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR, especially in the presence of lower concentrations of plasma folate.

  10. Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans: data from the fourth Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2009.

    Science.gov (United States)

    Baek, Kiook; Lee, Namhoon; Chung, Insung

    2017-01-01

    Arsenic is known as an endocrine disruptor that people are exposed to through various sources such as drinking water and indigestion of marine products. Although some epidemiological and animal studies have reported a correlation between arsenic exposure and diabetes development, there are limited studies regarding the toxic effects of organic arsenic including arsenobetaine on the human body. Here, we analyzed the association between urine arsenobetaine and the homeostasis model assessment of β-cell function (HOMA-β), which is an index for predicting diabetes development and reflecting the function of pancreatic β-cells. In the fourth Korea National Health and Nutrition Examination Survey (KNHANES), health and nutrition surveys and screening tests were performed. Of the total survey population, people with confirmed values for urine total arsenic and arsenobetaine were included, and known diabetic patients were excluded. A total 369 participants were finally included in the study. We collected surveys on health, height, body weight, body mass index, blood mercury level, fasting glucose level, and serum insulin level and calculated HOMA index. Owing to sexual discrepancy, we performed sexually stratified analysis. Urine total arsenic and total arsenic minus arsenobetaine was not associated with HOMA-IR and HOMA-β in univariate analysis or in sexually stratified analysis. However, urine arsenobetaine showed a statistically significant relationship with HOMA-β in univariate analysis, and only male participants showed a significant correlation in sexually stratified analysis. In the analysis adjusted for age, BMI, smoking, alcohol drinking, physical activity and blood mercury, the HOMA-β value in the group below the 25th percentile of arsenobetaine was significantly higher than the group between 50 and 75th percentile, while no difference was shown for HOMA-IR. In sexually stratified analysis, The value of HOMA-β was significantly higher in male participants

  11. Increase in homeostasis model assessment of insulin resistance (HOMA-IR) had a strong impact on the development of type 2 diabetes in Japanese individuals with impaired insulin secretion: the Saku study.

    Science.gov (United States)

    Morimoto, Akiko; Tatsumi, Yukako; Soyano, Fumie; Miyamatsu, Naomi; Sonoda, Nao; Godai, Kayo; Ohno, Yuko; Noda, Mitsuhiko; Deura, Kijyo

    2014-01-01

    Our aim was to assess the impact of increase in homeostasis model assessment of insulin resistance (HOMA-IR) on the development of type 2 diabetes in Japanese individuals with impaired insulin secretion (IIS). This study included 2,209 participants aged 30-69 without diabetes at baseline who underwent comprehensive medical check-ups between April 2006 and March 2007 at Saku Central Hospital. Participants were classified into eight groups according to the combination of baseline IIS status (non-IIS and IIS) and category of HOMA-IR change between the baseline and follow-up examinations (decrease, no change/small increase, moderate increase, and large increase). Type 2 diabetes was determined from fasting and 2 h post-load plasma glucose concentrations at the follow-up examination between April 2009 and March 2011. At baseline, 669 individuals (30.3%) were classified as having IIS. At follow-up, 74 individuals developed type 2 diabetes. After adjusting for confounding factors including baseline HOMA-IR values, the multivariable-adjusted odds ratios (95% confidence intervals) for type 2 diabetes in the non-IIS with a decrease (mean change in HOMA-IR: -0.47), non-IIS with a moderate increase (mean change in HOMA-IR: 0.28), non-IIS with a large increase (mean change in HOMA-IR: 0.83), IIS with a decrease (mean change in HOMA-IR: -0.36), IIS with no change/small increase (mean change in HOMA-IR: 0.08), IIS with a moderate increase (mean change in HOMA-IR: 0.27), and IIS with a large increase (mean change in HOMA-IR: 0.73) groups, relative to the non-IIS with no change/small increase (mean change in HOMA-IR: 0.08) group were 0.23 (0.04, 1.11), 1.22 (0.26, 5.72), 2.01 (0.70, 6.46), 1.37 (0.32, 4.28), 3.60 (0.83, 15.57), 5.24 (1.34, 20.52), and 7.01 (1.75, 24.18), respectively. Moderate and large increases in HOMA-IR had a strong impact on the development of type 2 diabetes among individuals with IIS in this Japanese population.

  12. Alluvial systems as archives for environmental change at a Hominid site with Oldowan archaeological occurrences: the Homa Peninsula, southwestern Kenya

    Science.gov (United States)

    Vincent, Thomas; Whitfield, Elizabeth; Kirby, Jason; Hunt, Christopher; Bishop, Laura; Plummer, Thomas; Ditchfield, Peter

    2016-04-01

    The Homa Peninsula, southwestern Kenya, preserves fossiliferous sedimentary sequences dating to the Plio-Pleistocene. Evidence of hominids inhabiting an open grassland setting and utilising Oldowan tools has been reported here, as well as some of the oldest known traces of hominin activity. Reconstructions of the palaeoenvironment have suggested that alluvial and lake marginal environments on a grassy plain, between wooded slopes and a permanent water body might be plausible. However, these interpretations are based only on field sedimentological analyses and stable isotope analysis at a single site on the peninsula (Kanjera South). It is the aim of this study to utilise a multiproxy approach to develop our understanding of the palaeoenvironmental characteristics here. Sediments will also be characterized at a new site (Nyayanga) through field analyses, as well as through analyses of particle size, siliceous microfossils (diatoms, phytoliths and sponge spicules), pollen and stable isotopes. By utilizing this approach, new insights into the palaeoecology, palaeohydromorphology and palaeoclimate of the locale may be revealed, expanding the limited data available to palaeoanthropological studies of Oldowan occurrences in east Africa. Efforts to refine palaeoenvironmental reconstructions of Kanjera South through particle size analysis have shown that sediments in the lower beds of the sequence are characterised by poor sorting, a bimodal distribution and sand/silty-sand grade material. This suggests rapid deposition and/or a variable hydrological regime and may represent the role of relatively unconfined ephemeral channels in the transportation and deposition of sediments. Fluvial reworking of aeolian sediments, most likely during unconfined flood events may also have occurred.

  13. Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial.

    Science.gov (United States)

    Tepper, S; Shahar, D R; Geva, D; Ish-Shalom, S

    2016-06-01

    Vitamin D is thought to play a role in glucose metabolism. The aim of the present study was to determine the effect of vitamin D supplementation on markers of insulin sensitivity and inflammation in men without diabetes with vitamin D deficiency/insufficiency. In this 1-year double-blind randomized controlled trial, 130 men aged 20-65 years (mean age 47.52 ± 11.84 years) with serum 25-hydroxyvitamin D levels HOMA-IR) values between groups. Levels of insulin and HOMA-IR values remained steady during the study period in the treatment group but increased by 16% in the control group (p = 0.038 and p = 0.048, respectively). Vitamin D supplementation administered for 12 months in healthy men maintained insulin levels and HOMA-IR values relative to the increase in the control group. Further studies are needed to establish the long-term effect of vitamin D supplementation on the risk of diabetes. © 2016 John Wiley & Sons Ltd.

  14. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR): A Better Marker for Evaluating Insulin Resistance Than Fasting Insulin in Women with Polycystic Ovarian Syndrome.

    Science.gov (United States)

    Majid, Hafsa; Masood, Qamar; Khan, Aysha Habib

    2017-03-01

    To assess the utility of HOMA-IR in assessing insulin resistance in patients with polycystic ovary syndrome (PCOS) and compare it with fasting insulin for assessing insulin resistance (IR). Observational study. Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from January 2009 to September 2012. Medical chart review of all women diagnosed with PCOS was performed. Of the 400 PCOS women reviewed, 91 met the inclusion criteria. Insulin resistance was assessed by calculating HOMA-IR using the formula (fasting glucose x fasting insulin)/405, taking normal value HOMA-IR of women was 3.1 ±1.7, respectively with IR in 69% (n=63) women, while hyperinsulinemia was present in 60% (n=55) women (fasting Insulin 18.5 ±5.8 µIU/ml). Hyperandrogenism was present in 53.8% (n=49), whereas 38.5% (n=35) women had primary infertility or subfertility, while 65.9% (n=60) had menstrual irregularities; and higher frequencies were observed in women with IR. Eight subjects with IR and endocrine abnormalities were missed by fasting insulin. Insulin resistance is common in PCOS and it is likely a pathogenic factor for development of PCOS. HOMAIR model performed better than hyperinsulinemia alone for diagnosing IR.

  15. Percentiles of fasting serum insulin, glucose, HbA1c and HOMA-IR in pre-pubertal normal weight European children from the IDEFICS cohort.

    Science.gov (United States)

    Peplies, J; Jiménez-Pavón, D; Savva, S C; Buck, C; Günther, K; Fraterman, A; Russo, P; Iacoviello, L; Veidebaum, T; Tornaritis, M; De Henauw, S; Mårild, S; Molnár, D; Moreno, L A; Ahrens, W

    2014-09-01

    The aim of this study is to present age- and sex-specific reference values of insulin, glucose, glycosylated haemoglobin (HbA1c) and the homeostasis model assessment to quantify insulin resistance (HOMA-IR) for pre-pubertal children. The reference population consists of 7074 normal weight 3- to 10.9-year-old pre-pubertal children from eight European countries who participated in at least one wave of the IDEFICS ('identification and prevention of dietary- and lifestyle-induced health effects in children and infants') surveys (2007-2010) and for whom standardised laboratory measurements were obtained. Percentile curves of insulin (measured by an electrochemiluminescence immunoassay), glucose, HbA1c and HOMA-IR were calculated as a function of age stratified by sex using the general additive model for location scale and shape (GAMLSS) method. Levels of insulin, fasting glucose and HOMA-IR continuously show an increasing trend with age, whereas HbA1c shows an upward trend only beyond the age of 8 years. Insulin and HOMA-IR values are higher in girls of all age groups, whereas glucose values are slightly higher in boys. Median serum levels of insulin range from 17.4 and 13.2 pmol l(-1) in 3-HOMA-IR, median values range from 0.5 and 0.4 in 3-<3.5-year-old girls and boys to 1.7 and 1.4 in 10.5-<11-year-old girls and boys, respectively. Our study provides the first standardised reference values for an international European children's population and provides the, up to now, largest data set of healthy pre-pubertal children to model reference percentiles for markers of insulin resistance. Our cohort shows higher values of Hb1Ac as compared with a single Swedish study while our percentiles for the other glucose metabolic markers are in good accordance with previous studies.

  16. Fundamentos Curriculares del Liceo Laboratorio Emma Gamboa: Construcción teórica a partir de una Institución Participativa

    Directory of Open Access Journals (Sweden)

    Gurdián Fernández, Alicia

    2002-12-01

    Full Text Available Este artículo presenta los fundamentos teóricos del Proyecto Pedagógico del Liceo Laboratorio Emma Gamboa elaborados por las investigadoras a partir de una reflexión teórica que retoma la visión y la misión con las que se creó el Liceo, la percepción y el análisis en el marco de una evaluación curricular llevada a cabo por las investigadoras, el personal docente y docente administrativo. Estos fundamentos son resultado de una investigación participativa que permitió al personal docente y docente administrativo del período de 1996 a 1998, definir las premisas conceptuales que caracterizan a ese proyecto curricular desde un punto de vista epistemológico.

  17. Ricardo, Marx y Keynes ante la Ley de Say : fundamentos microeconómicos de esta ley y de su crítica

    OpenAIRE

    Posada Posada, Carlos Esteban

    1980-01-01

    El objetivo del presente artículo está expresado sintéticamente en el título, refiriéndose entonces, a las relaciones lógicas existentes entre: A) Las teorías ricardiana, marxista y Keynesiana de los precios y B) La posición de Ricardo, Marx y Keynes con respecto a dicha Ley. Se deduce de lo anterior que este artículo no estudia los fundamentos neo-clásicos de la Ley de Say o de sus críticas, aunque lo corriente sea identificar los términos: "fundamentos microeconómicos" de tesis macroeconómi...

  18. La dignidad de la persona como fundamento del orden jurídico. La teoría del sujeto de derecho penal

    Directory of Open Access Journals (Sweden)

    Carlos Arturo Gómez Pavajeau

    2011-12-01

    Full Text Available La dignidad de la persona ha sido elevada a la categoría de fundamento del orden jurídico por la Carta Política colombiana. Puede afirmarse, sin ninguna duda, que se constituye en el principio de los principios de nuestro ordenamiento jurídico, con claras repercusiones en el ámbito de los derechos fundamentales y en la conformación de las categorías jurídico-penales, razón suficiente para presentar su origen, conceptualización e influencia en el fundamento y la estructura de la responsabilidad penal, pues se erige como la norma que norma todo lo jurídico.

  19. Contexto do ensino de fundamentos teóricos de biblioteconomia na UFSCThe teaching of theoretical foundations of library science in the UFSC

    Directory of Open Access Journals (Sweden)

    Francisco das Chagas de Souza

    2001-12-01

    Full Text Available It presents a didactic-pedagogical proposal in development in the Library Science undergraduated course of the FederalUniversity of Santa Catarina, Brazil, realized in form of seminaries in the discipline "Special Topics in Librarianship.Apresenta proposta didático-pedagógica - e seus fundamentos - em desenvolvimento no Currículo do Curso de Biblioteconomia da Universidade Federal de Santa Catarina, cuja execução se dá através da realização de seminários na disciplina Tópicos Especiais em Biblioteconomia a qual faz parte do núcleo disciplinar de Fundamentos Teóricos de Biblioteconomia.

  20. Informática I (Fundamentos de la informática para los nuevos estudiantes de Grado) (2009/2010)

    OpenAIRE

    Grimaldo Moreno, Francisco; Giménez Sánchez, Juan Vicente; Navalón Martínez, José Ángel

    2009-01-01

    Esta asignatura cubre los fundamentos de las Tecnologías de la Información y la Comunicación (TIC), la arquitectura de los computadores y los conceptos generales de los algoritmos. Además, introduce los sistemas operativos y las redes de comunicación, junto con una formación avanzada con paquetes de ofimática.

  1. The incidence of metabolic syndrome in obese Czech children: the importance of early detection of insulin resistance using homeostatic indexes HOMA-IR and QUICKI.

    Science.gov (United States)

    Pastucha, D; Filipčíková, R; Horáková, D; Radová, L; Marinov, Z; Malinčíková, J; Kocvrlich, M; Horák, S; Bezdičková, M; Dobiáš, M

    2013-01-01

    Common alimentary obesity frequently occurs on a polygenic basis as a typical lifestyle disorder in the developed countries. It is associated with characteristic complex metabolic changes, which are the cornerstones for future metabolic syndrome development. The aims of our study were 1) to determine the incidence of metabolic syndrome (based on the diagnostic criteria defined by the International Diabetes Federation for children and adolescents) in Czech obese children, 2) to evaluate the incidence of insulin resistance according to HOMA-IR and QUICKI homeostatic indexes in obese children with and without metabolic syndrome, and 3) to consider the diagnostic value of these indexes for the early detection of metabolic syndrome in obese children. We therefore performed anthropometric and laboratory examinations to determine the incidence of metabolic syndrome and insulin resistance in the group of 274 children with obesity (128 boys and 146 girls) aged 9-17 years. Metabolic syndrome was found in 102 subjects (37 %). On the other hand, the presence of insulin resistance according to QUICKI HOMA-IR >3.16 in 53 % of obese subjects. This HOMA-IR limit was exceeded by 70 % children in the MS(+) group, but only by 43 % children in the MS(-) group (p<0.0001). However, a relatively high incidence of insulin resistance in obese children without metabolic syndrome raises a question whether the existing diagnostic criteria do not falsely exclude some cases of metabolic syndrome. On the basis of our results we suggest to pay a preventive attention also to obese children with insulin resistance even if they do not fulfill the actual diagnostic criteria for metabolic syndrome.

  2. Use of HbA(1C) testing to diagnose pre-diabetes in high risk African American children: a comparison with fasting glucose and HOMA-IR.

    Science.gov (United States)

    Sharma, Sushma; Fleming, Sharon E

    2012-01-01

    This study aimed to compare the discriminating power of HbA(1C) with other pre-diabetes diagnostic tests specifically in high-risk African American children. A cross-sectional analysis was performed on a sample of 172 children (70 boys and 102 girls) aged 9-11 years with BMI's above the 85th percentile. Fasting glucose, insulin and HbA(1C) were analyzed from the plasma samples. Of the 172 participants included in this analysis, 21 (12.2%) had HbA(1C) concentrations above the cutoff of 5.7 used to identify pre-diabetes. None (0%) of these 21 participants, however, were observed to have a glucose concentration above the pre-diabetes cutoff of 110 mg/dl, and only 13 of 21 participants had HOMA-IR above the pre-diabetes cutoff of 2.5. When compared to the previously identified glucose cutoff of 110 mg/dl and HOMA-IR cutoff of 2.5 for pre-diabetes, HbA(1C) showed high specificity (88 and 93%, respectively) but very low sensitivity (0 and 21%, respectively). Glucose, insulin and HOMA-IR were significantly interrelated, but HbA(1C) was not significantly correlated with these biochemical prediabetes assessment variables, nor with anthropometric (BMIz, WC) risk factors. Our results suggest that HbA(1C) had poor discrimination power to identify prediabetes in overweight and obese 9- to 11-year-old African American children. Future studies are recommended to compare the feasibility, sensitivity and predictive power of different screening tests currently recommended to avoid inadequacy when screening for prediabetes and diabetes. Copyright © 2012 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  3. Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA-IR in subjects of a west-African population.

    Science.gov (United States)

    Awede, Bonaventure; Adovoekpe, Diane; Adehan, Grace; MacFarlane, Niall G; Azonbakin, Simon; Dossou, Emmanuel; Amoussou-Guenou, Marcellin; Djrolo, François

    2018-06-01

    Factors associated with plasma levels of adiponectin and leptin were studied in adult subjects without diabetes from Cotonou in Benin (West-Africa). Seventy (70) men and 45 women were included in the study. Anthropometric variables were measured and a venous blood sample was drawn from each subject, after an overnight fasting period, for measurement of plasma glucose, insulin, leptin, and adiponectin levels. HOMA-IR was determined to assess insulin resistance. Adiponectin and leptin levels were higher in women than in men (with adiponectin 18.48 ± 12.77 vs.7.8 ± 10.39 μg/mL, P HOMA-IR were also higher in the females. Hyperleptinemia was observed in 66,96% of subjects and hypoadiponectinemia was present in 44.35% of subjects. In both men and women, leptin correlated with age (r = 0.2; P = 0.02), BMI (r = 0.572; P HOMA-IR (r = 0.430; P < 0.0001). No significant correlation was observed for adiponectin levels with these variables. Only in women, adiponectin was inversely correlated with fasting glucose (r = -0.423; P < 0.004). These data confirm previous descriptions of leptin but suggest that variations in factors determining serum adiponectin levels observed between ethnicities could also been seen between populations from the same ethnicity. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  4. Relationship between high white blood cell count and insulin resistance (HOMA-IR) in Korean children and adolescents: Korean National Health and Nutrition Examination Survey 2008-2010.

    Science.gov (United States)

    Park, J-M; Lee, D-C; Lee, Y-J

    2017-05-01

    Increasing evidence has indicated that insulin resistance is associated with inflammation. However, few studies have investigated the association between white blood cell (WBC) count and insulin resistance, as measured by a homeostasis model assessment of insulin resistance (HOMA-IR) in a general pediatric population. This study aimed to examine the association between WBC count and insulin resistance as measured by HOMA-IR in a nationally representative sample of children and adolescents. In total, 2761 participants (1479 boys and 1282 girls) aged 10-18 years were selected from the 2008-2010 Korean National Health and Nutrition Examination Survey. Insulin resistance was defined as a HOMA-IR value greater than the 90th percentile. The odds ratios and 95% confidence intervals for insulin resistance were determined using multiple logistic regression analysis. The mean values of most cardiometabolic variables tended to increase proportionally with WBC count quartiles. The prevalence of insulin resistance significantly increased in accordance with WBC count quartiles in both boys and girls. Compared to individuals in the lowest WBC count quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.84 in boys and 3.20 in girls, after adjusting for age, systolic blood pressure, body mass index, and waist circumference. A higher WBC count was positively associated with an increased risk of insulin resistance in Korean children and adolescents. This study suggests that WBC count could facilitate the identification of children and adolescents with insulin resistance. Copyright © 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

  5. Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study.

    Science.gov (United States)

    Hidalgo, Bertha; Irvin, M Ryan; Sha, Jin; Zhi, Degui; Aslibekyan, Stella; Absher, Devin; Tiwari, Hemant K; Kabagambe, Edmond K; Ordovas, Jose M; Arnett, Donna K

    2014-02-01

    Known genetic susceptibility loci for type 2 diabetes (T2D) explain only a small proportion of heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation in diabetes-related risk factors, and this epigenetic variation across the genome can contribute to the missing heritability in T2D and related metabolic traits. We conducted an epigenome-wide association study for fasting glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) among 837 nondiabetic participants in the Genetics of Lipid Lowering Drugs and Diet Network study, divided into discovery (N = 544) and replication (N = 293) stages. Cytosine guanine dinucleotide (CpG) methylation at ∼470,000 CpG sites was assayed in CD4(+) T cells using the Illumina Infinium HumanMethylation 450 Beadchip. We fit a mixed model with the methylation status of each CpG as the dependent variable, adjusting for age, sex, study site, and T-cell purity as fixed-effects and family structure as a random-effect. A Bonferroni corrected P value of 1.1 × 10(-7) was considered significant in the discovery stage. Significant associations were tested in the replication stage using identical models. Methylation of a CpG site in ABCG1 on chromosome 21 was significantly associated with insulin (P = 1.83 × 10(-7)) and HOMA-IR (P = 1.60 × 10(-9)). Another site in the same gene was significant for HOMA-IR and of borderline significance for insulin (P = 1.29 × 10(-7) and P = 3.36 × 10(-6), respectively). Associations with the top two signals replicated for insulin and HOMA-IR (P = 5.75 × 10(-3) and P = 3.35 × 10(-2), respectively). Our findings suggest that methylation of a CpG site within ABCG1 is associated with fasting insulin and merits further evaluation as a novel disease risk marker.

  6. Size and shape of the associations of glucose, HbA1c, insulin and HOMA-IR with incident type 2 diabetes: the Hoorn Study.

    Science.gov (United States)

    Ruijgrok, Carolien; Dekker, Jacqueline M; Beulens, Joline W; Brouwer, Ingeborg A; Coupé, Veerle M H; Heymans, Martijn W; Sijtsma, Femke P C; Mela, David J; Zock, Peter L; Olthof, Margreet R; Alssema, Marjan

    2018-01-01

    Glycaemic markers and fasting insulin are frequently measured outcomes of intervention studies. To extrapolate accurately the impact of interventions on the risk of diabetes incidence, we investigated the size and shape of the associations of fasting plasma glucose (FPG), 2 h post-load glucose (2hPG), HbA 1c , fasting insulin and HOMA-IR with incident type 2 diabetes mellitus. The study population included 1349 participants aged 50-75 years without diabetes at baseline (1989) from a population-based cohort in Hoorn, the Netherlands. Incident type 2 diabetes was defined by the WHO 2011 criteria or known diabetes at follow-up. Logistic regression models were used to determine the associations of the glycaemic markers, fasting insulin and HOMA-IR with incident type 2 diabetes. Restricted cubic spline logistic regressions were conducted to investigate the shape of the associations. After a mean follow-up duration of 6.4 (SD 0.5) years, 152 participants developed diabetes (11.3%); the majority were screen detected by high FPG. In multivariate adjusted models, ORs (95% CI) for incident type 2 diabetes for the highest quintile in comparison with the lowest quintile were 9.0 (4.4, 18.5) for FPG, 6.1 (2.9, 12.7) for 2hPG, 3.8 (2.0, 7.2) for HbA 1c , 1.9 (0.9, 3.6) for fasting insulin and 2.8 (1.4, 5.6) for HOMA-IR. The associations of FPG and HbA 1c with incident diabetes were non-linear, rising more steeply at higher values. FPG was most strongly associated with incident diabetes, followed by 2hPG, HbA 1c , HOMA-IR and fasting insulin. The strong association with FPG is probably because FPG is the most frequent marker for diabetes diagnosis. Non-linearity of associations between glycaemic markers and incident type 2 diabetes should be taken into account when estimating future risk of type 2 diabetes based on glycaemic markers.

  7. Gamma glutamyl transferase is an independent determinant for the association of insulin resistance with nonalcoholic fatty liver disease in Bangladeshi adults: Association of GGT and HOMA-IR with NAFLD.

    Science.gov (United States)

    Hossain, Israt Ara; Rahman Shah, Md Mijanur; Rahman, Mohammad Khalilur; Ali, Liaquat

    2016-01-01

    Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and is frequently associated with insulin resistance (HOMA-IR) syndrome. Recently serum gamma glutamyl transferase (GGT) has been considered as surrogate marker of NAFLD leading to oxidative stress and hepatocellular damage. In the present study we examined the association of serum GGT and HOMA-IR with NAFLD in Bangladeshi adult subjects. Under a cross-sectional analytical design a total of 110 subjects were recruited who came for their routine health check up in the BIHS Hospital, Darussalam, Dhaka, Bangladesh. After whole abdomen ultrasonography, 62 were diagnosed as non-NAFLD and 48 were NAFLD subjects. Serum glucose was measured by glucose-oxidase method, lipid profile and liver enzymes by enzymatic colorimetric method, glycosylated hemoglobin (HbA1c) was measured by high performance liquid chromatography (HPLC), serum insulin were measured by enzyme-linked immunosorbent assay. HOMA-IR was calculated by homeostasis model assessment (HOMA). NAFLD subjects had significantly higher levels of GGT and HOMA-IR as compared to their non-NAFLD counterparts. Multiple linear regression analysis showed a significant positive association of HOMA-IR with GGT after adjusting the effects of waist circumference (WC) and HbA1c. In binary logistic regression analysis, HOMA-IR and GGT were found to be significant determinants of NAFLD after adjusting the effects of WC and HbA1c. These results suggest that elevated levels of GGT and insulin resistance are more likely to develop NAFLD and thus support a role of these determinants in the pathogenesis of NAFLD in Bangladeshi adult subjects. Copyright © 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  8. Assessment of trace metal concentrations and human health risk in clam (Tapes decussatus) and mussel (Mytilus galloprovincialis) from the Homa Lagoon (Eastern Aegean Sea).

    Science.gov (United States)

    Bilgin, Mustafa; Uluturhan-Suzer, Esin

    2017-02-01

    Seasonal variations of trace metal concentrations (Hg, Cd, Pb, Cr, Zn, and Cu) were investigated in the hepatopancreas and soft tissues (remaining parts of bivalves such as gill, mantle, foot, and muscle) of Tapes decussatus and Mytilus galloprovincialis from the Homa Lagoon. The highest metal concentrations were recorded frequently in February and July in M. galloprovincialis and T. decussatus, respectively. Trace metal levels (except Zn) in the hepatopancreas were higher than those in soft tissue for both bivalves. The results showed that the mean concentrations of Hg, Cd, and Zn for M. galloprovincialis were higher compared to T. decussatus in both tissues. The metal concentrations in both bivalves from the Homa Lagoon were generally below the values of provisional tolerable weekly intake (PTWI) estimates, in terms of human health risk. According to hazard quotient (HQ), Cr values for both species and Cd values for only M. galloprovincialis were found greater than one. Also, total hazard index (THI) values were greater than one in both bivalves, having a potential risk for consumers.

  9. Effects of crocin and voluntary exercise, alone or combined, on heart VEGF-A and HOMA-IR of HFD/STZ induced type 2 diabetic rats.

    Science.gov (United States)

    Ghorbanzadeh, V; Mohammadi, M; Dariushnejad, H; Chodari, L; Mohaddes, G

    2016-10-01

    Hyperglycemia is the main risk factor for microvascular complications in type 2 diabetes. Crocin and voluntary exercise have anti-hyperglycemic effects in diabetes. In this research, we evaluated the effects of crocin and voluntary exercise alone or combined on glycemia control and heart level of VEGF-A. Animals were divided into eight groups as: control (con), diabetes (Dia), crocin (Cro), voluntary exercise (Exe), crocin and voluntary exercise (Cro-Exe), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by a high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p, 35 mg/kg). Animals received oral administration of crocin (50 mg/kg) or performed voluntary exercise alone or together for 8 weeks. Oral glucose tolerance test (OGTT) was performed on overnight fasted control, diabetic and treated rats after 8 weeks of treatment. Then, serum insulin and heart VEGF-A protein levels were measured. Crocin combined with voluntary exercise significantly decreased blood glucose levels (p HOMA-IR) (p HOMA-IR) and reduced glucose levels in diabetic rats. Since both crocin and voluntary exercise can increase VEGF-A protein expression in heart tissue, they probably are able to increase angiogenesis in diabetic animals.

  10. Association between HOMA-IR, fasting insulin and fasting glucose with coronary heart disease mortality in nondiabetic men: a 20-year observational study.

    Science.gov (United States)

    Kurl, Sudhir; Zaccardi, Francesco; Onaemo, Vivian N; Jae, Sae Young; Kauhanen, Jussi; Ronkainen, Kimmo; Laukkanen, Jari A

    2015-02-01

    Whether glucose and insulin are differently associated with the risk of coronary heart disease (CHD) mortality is unclear. We aimed to estimate the association between insulin resistance (estimated by the homeostasis model assessment for insulin resistance, HOMA-IR), fasting serum insulin (FI) and fasting plasma glucose (FPG) with incident CHD mortality in a prospective study including middle-aged nondiabetic Finnish men. During an average follow-up of 20 years, 273 (11 %) CHD deaths occurred. In a multivariable Cox regression analysis adjusted for age, body mass index, systolic blood pressure, serum LDL-cholesterol, cigarette smoking, history of CHD, alcohol consumption, blood leukocytes and plasma fibrinogen, the hazard ratios (HRs) for CHD mortality comparing top versus bottom quartiles were as follows: 1.69 (95 % CI: 1.15-2.48; p = 0.008) for HOMA-IR; 1.59 (1.09-2.32; p = 0.016) for FI; and 1.26 (0.90-1.76; p = 0.173) for FPG. These findings suggest that IR and FI, but not FPG, are independent risk factors for CHD mortality. Further studies could help clarify these results in terms of screening and risk stratification, causality of the associations, and therapeutical implications.

  11. Linking lifestyle factors and insulin resistance, based on fasting plasma insulin and HOMA-IR in middle-aged Japanese men: a cross-sectional study.

    Science.gov (United States)

    Otake, Toshie; Fukumoto, Jin; Abe, Masao; Takemura, Shigeki; Mihn, Pham Ngoc; Mizoue, Tetsuya; Kiyohara, Chikako

    2014-09-01

    Insulin resistance (IR) is regarded as one of the earliest features of many metabolic diseases, and major efforts are aimed at improving insulin function to confront this issue. The aim of this study was to investigate the relationship of body mass index (BMI), cigarette smoking, alcohol intake, physical activity, green tea and coffee consumption to IR. We performed a cross-sectional study of 1542 male self defense officials. IR was defined as the highest quartile of the fasting plasma insulin (≥ 50 pmol/L) or the homeostasis model assessment-estimated IR (HOMA-IR ≥ 1.81). An unconditional logistic model was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between IR and influential factors. Stratified analysis by obesity status (BMI IR was significantly positively related to BMI and glucose tolerance, negatively related to alcohol use. Independent of obesity status, significant trends were observed between IR and alcohol use. Drinking 30 mL or more of ethanol per day reduced IR by less than 40%. Strong physical activity was associated with decreased risk of IR based on fasting plasma insulin only in the obese. Coffee consumption was inversely associated with the risk of IR based on HOMA-IR in the non-obese group. Higher coffee consumption may be protective against IR among only the non-obese. Further studies are warranted to examine the effect modification of the obesity status on the coffee-IR association.

  12. Obese adolescent girls with polycystic ovary syndrome (PCOS) have more severe insulin resistance measured by HOMA-IR score than obese girls without PCOS.

    Science.gov (United States)

    Sawathiparnich, Pairunyar; Weerakulwattana, Linda; Santiprabhob, Jeerunda; Likitmaskul, Supawadee

    2005-11-01

    The prevalence of obesity in Thai children is increasing. These individuals are at increased risks of metabolic syndrome that includes insulin resistance, type 2 diabetes mellitus (T2DM), polycystic ovary syndrome (PCOS), dyslipidemia and hypertension. PCOS has been known to be associated with insulin resistance. To compare the insulin sensitivity between obese adolescent girls with PCOS and those without PCOS. We reviewed demographic and hormonal data of 6 obese adolescent girls with PCOS and compared with 6 age, weight and BMI-matched non-PCOS controls. Each subject underwent an oral glucose tolerance test. Homeostasis model assessment of insulin resistance score (HOMA-IR score) in obese adolescent girls with PCOS was significantly higher than in girls without PCOS with median and range as follows (16.5 [3.8, 21.8] vs. 4.1 [3.3, 6.9], p = 0.04). Our study demonstrates that obese adolescent girls with PCOS have more severe insulin resistance measured by HOMA-IR score than girls without PCOS independent of the degree of obesity. Since insulin resistance is a metabolic precursor of future cardiovascular diseases, obese adolescent girls with PCOS might be at greater risk of developing cardiovascular disease in later adulthood than their non-PCOS counterparts.

  13. Estudo da produção cientifica em introdução e fundamentos de enfermagem

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    Emília Luigia Saporiti Angerámi

    1985-03-01

    Full Text Available Para avaliação da produção do conhecimento em Introdução à Enfermagem e/ou Fundamentos de Enfermagem foi efetuada uma revisão da questão semântica para, a seguir, percorrermos o aspecto conceituai. Considerando que a disciplina em questão sofreu transformações significantes no seu conteúdo programático, o qual influenciou e foi influenciado pela pesquisa, estruturamos a análise em quatro períodos que foram fixados a partir das mudanças no ensino. Para realização do estudo, buscamos as fontes de informação disponíveis, a saber: Revista Brasileira de Enfermagem, Revista da Escola de Enfermagem da USP, Revista Enfermagem em Novas Dimensões, os catálogos editados pelo CEPEn e os programas das Escolas de Enfermagem do Brasil. A análise dos resultados foi feita respeitando o proposto na metodologia, ou seja, por período, que indicam as tendências do ensino, da pesquisa e da assistência, tentando dar uma resposta às propostas vigentes. Concluímos que, tratando-se de um trabalho descritivo, permite expor situações, questionar os fatos descritos e buscar relações que os expliquem. As interpretações histórico-sociais revestem-se de um caráter de aproximação ao problema, sendo importante que estudos futuros procurem analisar em profundidade a produção do conhecimento qualitativamente e sua relação com a prática.

  14. Fundamentos teóricos del proceso de formación profesional del Licenciado en Estudios Socioculturales

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    Dora Lilia Márquez Delgado

    2007-03-01

    Full Text Available Ante la necesidad de perfeccionar el proceso de formación profesional de los estudiantes de la carrera de Estudios Socioculturales, el trabajo presenta los fundamentos teóricos del diseño de dicho proceso, en el cual se tiene en cuenta el modo de actuación profesional, sobre la base de problemas, expresando una adecuada correspondencia entre lo disciplinario y lo profesional. La investigación realizada permitió analizar que el Licenciado en Estudios Socioculturales desde su formación inicial, debe capacitarse para gestionar el desarrollo sociocultural, lo que supone la integración y sistematización de los momentos de la gestión sociocultural como máxima actividad profesional. Este proceso es representado a través de los componentes que lo integran y su sistema de relaciones, lo cual permite determinar cuatro etapas en el proceso de formación del Licenciado en Estudios Socioculturales. Como resultado de esta modelación, se logra la definición de este proceso. Para fundamentar dicho proceso se asumen las siguientes teorías: teoría del enfoque histórico – cultural, la teoría de los Procesos Conscientes desarrollada por Carlos Álvarez de Zayas y el Modelo en base a la lógica esencial de la profesión, la teoría del pensamiento complejo de Edgar Morin, así como concepciones que explican lo sociocultural.

  15. Gestão de odores: fundamentos do Nariz Eletrônico Odor management: fundamentals of Electronic Nose

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    Henrique de Melo Lisboa

    2009-03-01

    Full Text Available Narizes Eletrônicos têm sido desenvolvidos para detecção automática e classificação de odores, vapores e gases. São instrumentos capazes de medir a concentração ou intensidade odorante de modo similar a um olfatômetro, mas sem as limitações inerentes ao uso de painéis humanos, o que é altamente desejável. Um Nariz Eletrônico é geralmente composto por um sistema de sensores químicos e um sistema eletrônico associado à inteligência artificial para reconhecimento. Têm sido aplicados em muitas áreas, tais como análise de alimentos, controles ambientais e diagnósticos médicos. Do ponto de vista ambiental, sistemas de Narizes Eletrônicos vêm sendo usados para monitorar a qualidade do ar, detectar fontes e quantificar emissões odorantes. Este artigo pretende apresentar os fundamentos dos Narizes Eletrônicos.Electronic noses have been developed for automatic detection and classification of odors, vapors and gases. They are instruments capable to identify odors as the human nose does, and measure the odor concentration or intensity according to similar metrics as an olfactometer, but without the inherent limitations of human panels. An Electronic Nose is generally composed of a matrix of chemical sensors and computer based system for odor recognition and classification. It has been applied in many areas, such as food quality analysis, explosives detection, environmental monitoring and medical diagnosis. In the ambient environment, systems of Electronic Noses have been used to monitor the quality of air and to detect and quantify odor sources and emissions. This article intends to present the fundamentals and main characteristics of Electronic Noses.

  16. La restricción de los derechos fundamentales : un concepto en evolución y su fundamento constitucional

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    María José Cabezudo Bajo

    2010-01-01

    Full Text Available El concepto de «restricción de los Derechos Fundamentales» presenta una extraordinaria utilidad para el campo del Derecho Procesal. Esta circunstancia se pone de relieve a la hora de precisar las exigencias constitucionales que han de cumplir aquellos actos procesales que inciden sobre derechos fundamentales para alcanzar la eficacia procesal que persiguen. Es el caso, por ejemplo, de la entrada y registro domiciliario, la intervención de las comunicaciones telefónicas o las novedosas medidas relativas a la intervención y acceso de los datos de tráfico de las comunicaciones electrónicas, así como a la obtención y tratamiento del ADN e, incluso, de las medidas que cabe adoptar para luchar contra la criminalidad organizada, como la infiltración de un agente encubierto o la instalación de aparatos de escucha sobre un domicilio, cuya adopción, todos ellos, por parte del órgano jurisdiccional competente, está orientada a la PROPORCIONADA consecución de los fines propios del proceso penal, civil, así como del procedimiento administrativo. Por el hecho de incidir sobre derechos fundamentales, dichas actuaciones procesales deberían constituir restricciones o limitaciones de tales derechos, lo que significa que su eficacia procesal ha de estar sometida al más estricto cumplimiento de las exigencias constitucionales que dicha calificación conlleva. Por ello, ha de formularse el concepto de «restricción de los Derechos Fundamentales », con el objeto de precisar los presupuestos y requisitos que lo conforman. Este es precisamente el objeto de este trabajo, la exposición, en la medida en que resulta necesaria desde esta perspectiva procesal, del concepto, en evolución, de «restricción de los Derechos Fundamentales», así como su fundamento constitucional.

  17. Los fundamentos del Pensamiento y las Prácticas Administrativas. 2- LA TRILOGÍA ADMINISTRATIVA

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    Renée Bédard

    2004-06-01

    Full Text Available Para comprender las acciones y las conductas de una persona, es necesario rastrear los fundamento simplícitos. Esto exige prestar atención no sólo a las acciones concretas de la persona, a sus actitudes y a sus palabras, sino buscar sobre qué están profundamente apoyadas esas maneras de actuar, de comportarse y de hablar, más allá de las explicaciones racionales y lógicas que la persona pueda dar. Para lograr esto, he propuesto ya un marco de análisis que comporta cuatro partes estrechamente ligadas entre sí y que presento bajo la forma de un rombo.Luego de haber presentado cada uno de los cuatro elementos de base – las prácticas, los métodos, los valores y los principios generales – mostré cómo se podía utilizar el rombo para reconstituirla estructura íntima de una actividad concreta o de una conducta.A medida que progresaba mi investigación sobre un marco de análisis que me permitiera comprender y decodificar las experiencias o los hechos concretos vividos en el marco de mitrabajo administrativo, una segunda estructura comenzó a revelarse progresivamente como un telón de fondo, a la cual le llamé trilogía administrativa. Globalmente, se trata de tres grandes funciones de base que toda persona y toda sociedad deben realizar para sobrevivir ydesarrollarse.

  18. Fundamentos del metodo cientifico

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    Badii, M. H.

    2004-01-01

    Full Text Available El objetivo de esta obra no radica en realizar una búsqueda exhaustiva de la literatura en el tema, sino, sentar las bases del método científico, notando los aspectos filosóficos e éticos de la ciencia. Se presentan los conceptos y definiciones fundamentales relacionados con la metodología de la investigación científica. Se maneja el concepto de la toma de los datos válidos como un requisito básico en cualquier trabajo científico. Se pone a disposición del lector un modelo denominado el ECOEE que es una herramienta poderosa para establecer puntos de comparación e discusión entre los resultados de diferentes trabajos científicos. Finalmente, ofrece unas sugerencias de que hacer o no hacer en cuanto a realizar un trabajo de investigación.

  19. Fundamentos de finanzas corporativas

    OpenAIRE

    Becerra Plaza, Gisele Eugenia; Cubillos-Guzman, Luis-Francisco; Guzmán Vásquez, Alexánder; Guzmán Vásquez, David; Trujillo Dávila, María Andrea

    2006-01-01

    Si se considera que una inadecuada gestión financiera pone en riesgo la perdurabilidad de la empresa y los esfuerzos realizados por la organización en búsqueda constante del crecimiento, es de vital importancia que el profesional a cargo de funciones financieras cuente con una alta capacitación en herramientas de gestión. Este libro pretende acercar al estudiante a los conceptos básicos que soportan la gestión de las finanzas en el marco corporativo, familiarizándolo con las diferentes altern...

  20. Fundamentos de pesquisa institucional

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    Alexandre do Espírito Santo

    1982-11-01

    Full Text Available Discussion of problems related to integration and multiple leadership in Brazilian universities. Models designed to promote involvement of five mains groups of participants of the university system are suggested. Description, discussion, and interpretation of some techniques applied to institutional research aiming at implementation of the models for integration and multiple leadership.Descrição de problemas relativos à integração e liderança múltipla em universidades brasileiras. Apresentam-se modelos para o envolvimento dos cinco grupos componentes do sistema universitário. Descrição, discussão e interpretação de técnicas aplicadas em pesquisa institucional, visando à implementação dos modelos de integração e liderança múltipla.

  1. Correlation between Interleukin-6 (IL-6, High Sensitivity C-Reactive Protein (hsCRP, Endothelin-1 (ET-1, Asymmetric Dimethylarginine (ADMA and Insulin Resistance (HOMA-IR in Central Obese Men

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    Andri Hidayat

    2011-04-01

    Full Text Available BACKGROUND: Many studies have shown that obesity was closely related to insulin resistance via several pathways such as inflammation, oxidative stress, lipolysis, and endothelial dysfunction. This study was carried out to observe the correlation between inflammation (IL-6 and hsCRP, lipolysis process (ET-1, and endothelial dysfunction (ADMA and insulin resistance (HOMA-IR in centrally obese men. METHODS: This was a cross sectional study on 62 male subjects aged 30–60 years old with waist circumference (WC >90 cm. IL-6, ET-1 and ADMA levels were measured using ELISA method, while hsCRP and insulin were measured using chemiluminescence method. All blood testings were conducted in Prodia Clinical Laboratory. RESULTS: The results showed that WC was significantly correlated with hsCRP (r=0.294, p=0.022, ET-1 (r=0.257, p=0.047 and ADMA (r=0.338, p=0.009. We also found a significant correlation between hsCRP with HOMA-IR (r=0.324, p=0.021, ADMA with HOMA-IR (r=0.280, p=0.045 and IL-6 with hsCRP (r=0.437, p=0.003. CONCLUSIONS: hsCRP and ADMA have significant correlation with HOMA-IR in centrally obese men. HOMA-IR significantly increases in subjects with ADMA above median and either IL-6 or hsCRP above median, as compared to those in the other groups. Inflammation and endothelial dysfunction are important causal pathways of insulin resistance state in centrally obese men. KEYWORDS: obesity, IL-6, hsCRP, ET-1, ADMA, HOMA-IR.

  2. Fundamentos Teóricos del "Día Escolar de la NO Violencia y la Paz" (DENIP

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    Llorenç Vidal

    2003-01-01

    Full Text Available El Día Escolar de la No-violencia y la Paz (DENIP, que se practica el 30 de enero, aniversario del martirio del Mahatma Gandhi (en los países con calendarios del hemisferio sur el 30 de marzo o alguno de los días próximos, fue fundado en 1964 y es una de las más importantes experiencias de Educa-ción No-violenta y Pacificadora de nuestro tiempo, así como un núcleo en el que se han inspirado y tienen su origen la mayoría de iniciativas actuales de Educación en y para la No-violencia y la Paz-El DENIP tiene sus fundamentos teóricos en la filosofía y la práctica de la no-violencia (entendida como actitud de renunciar a matar y a dañar a los demás seres por medio del pensamiento, la palabra y la acción, como respe-to por la vida y como identificación con todo lo que vive, en la idea de paz positiva y de pacifismo no-violento integral, en el concepto de amor universal y en una concepción original de la Pedagogía y Educación en y para la No-violencia y la Paz, que se desarrolla a través de tres objetivos básicos (cons-cienciación, ejercitación y responsabilización del educando y un haz diver-sificado de siete órdenes de procedimientos didácticos. El Dr. Franz Rauhut, Profesor del la Universidad de Würzburg, escribió que el DENIP debería hacerse una costumbre en todas las escuelas del mundo. Sigue al artículo un anexo con las Orientaciones básicas del Día Escolar de la No-violencia y la Paz concebido como germen, punto de partida y de apoyo para una Educación No-violenta y Pacificadora de carácter universal, indepen-diente, abierto, profundo y permanente

  3. La responsabilidad civil del concesionario de obras viales y su fundamento en la obligación de seguridad respecto de los usuarios en el Derecho chileno

    OpenAIRE

    Diez Schwerter,José Luis

    2012-01-01

    Este trabajo analiza el reconocimiento y aplicación que tiene en Chile la obligación del concesionario de obras públicas viales de garantizar la seguridad de los usuarios en la utilización de las obras concesionadas, como fundamento de su responsabilidad civil. Verificando luego que a esta obligación se le ha dado un alcance homogéneo frente a hipótesis dañosas similares, se concluye destacando el acercamiento importante que genera entre los distintos regímenes de responsabilidad civil en bas...

  4. Fluorescencia molecular. Fundamentos teóricos. Obtención de espectros y análisis de una sustancia fluorescente

    OpenAIRE

    Espada Bellido, Estrella; Mendiguchía Martínez, Carolina; López López, José Antonio; Pinto, Juan J.

    2012-01-01

    En este video se explican detalladamente los fundamentos teóricos de la fluorescencia molecular, la disposición de cada uno de los componentes dentro un espectrofluorímetro mostrando las diferencias con respecto a un espectrofotómetro. Por otro lado, se muestran los distintos pasos para obtener los espectros de excitación y emisión, así como las etapas a llevar a cabo en el análisis de una sustancia fluorescente como la quinina.

  5. Os dois caminhos: uma investigação dos fundamentos das atitudes do metodismo con-servador na crise da década de sessenta

    OpenAIRE

    Daniel Augusto Schmidt

    2011-01-01

    RESUMOEste artigo estuda uma crise vivida pela Igreja Metodista na segunda metade da década de sessenta. Influenciado pelo ambiente político da ditadura militar, o metodismo brasileiro foi campo de um embate entre as alas liberais e conservadoras da denominação. Palco deste embate foi a Faculdade de Teologia e o II Concílio Geral Extraordinário, em 1968, além de uma série de eventos que a ele se seguiram durante os anos de 1969 e 1970. A pesquisa problematiza os fundamentos teológicos e ideol...

  6. La teoría de los valores en Miguel Reale : fundamento de su pensamiento filosófico-jurídico

    OpenAIRE

    Mateos García, María Ángeles

    1996-01-01

    La presente tesis estudia la teoría iusfilosofica de Miguel Reale en torno a una tesis principal: que su teoría del valor es el fundamento de su pensamiento filosófico-jurídico. Para demostrar este supuesto he estructurado el trabajo en 3 partes, persiguiendo dos objetivos básicos: 1.-mostrar el desarrollo y evolución del pensamiento iusfilosofico de Miguel Reale en torno a un hilo conductor: su teoría del valor. 2.-interpretar su axiología en relacion con otras explicaciones; desentrañando l...

  7. La Teoría del Autocuidado como Fundamento del Cuidado Integral de Enfermería a Pacientes con Hipertensión Arterial. Arequipa, 2017

    OpenAIRE

    Huerta Wilson, Marcia Christian

    2017-01-01

    El presente trabajo de investigación se titula: La teoría del autocuidado como fundamento del cuidado integral de enfermería a pacientes con hipertensión arterial realizado en la ciudad de Arequipa, en el año 2017. Se planteó como objetivo general establecer cómo el autocuidado favorece las capacidades en el paciente con hipertensión arterial mediante la intervención de Enfermería. Considerando que la hipertensión es un problema de salud pública mundial, el cual contribuye al aumento de cardi...

  8. A palaeoenvironmental reconstruction of c. 2 million year old Oldowan archaeological occurrences on the Homa Peninsula, southwestern Kenya: a multiproxy approach

    Science.gov (United States)

    Vincent, Thomas; Whitfield, Elizabeth; Kirby, Jason; Hunt, Christopher; Bishop, Laura; Plummer, Thomas; Ditchfield, Peter

    2016-04-01

    The Homa Peninsula, situated on the Winam Gulf of Lake Victoria, has yielded traces of hominin activity going back to at least ˜2ma BP. The best known site on the peninsula, Kanjera South, boasts large stone artefact and zooarchaeological assemblages preserved in three beds (from oldest to youngest: KS-1 to KS-3). Previous studies have used field sedimentological analyses, as well as stable isotope analysis of pedogenic carbonates to better understand the depositional and environmental contexts of hominin activities. These suggest that sediments were deposited in alluvial and lake marginal environments on a grassy plain, between wooded slopes and a permanent water body. The aim of this study is to refine previous palaeoenvironmental reconstructions of Kanjera South with the aid of particle size analysis, whilst also offering insights into the palaeoenvironment of other archaeological sites on the Homa Peninsula through a multiproxy approach. The project aims to include analyses of particle size, stable-isotopes, pollen and siliceous microfossils (phytoliths, diatoms and sponge spicules). Preliminary results of particle size and phytolith analyses have refined interpretations of the depositional environment at Kanjera South for beds KS1-3. Poor sorting, a bimodal distribution and sand/silty-sand grade material characterise the sediments. The characteristics suggest rapid deposition and/or a variable energy regime. A varying flow regime in relatively unconfined ephemeral channels might explain the transportation and deposition of sediments. Fluvial reworking of aeolian sediments, most likely during unconfined flood events may also have occurred. Phytoliths from the same beds showed grassland indicating Pooideae, as well as some Bambusoideae and woodland indicating phytoliths; this supports previous work.

  9. Diet-induced increases in chemerin are attenuated by exercise and mediate the effect of diet on insulin and HOMA-IR.

    Science.gov (United States)

    Lloyd, Jesse W; Zerfass, Kristy M; Heckstall, Ebony M; Evans, Kristin A

    2015-10-01

    Chemerin concentrations are elevated in obesity and associated with inflammation and insulin resistance. Exercise improves insulin sensitivity, which may be facilitated by changes in chemerin. We explored the effects of chronic exercise on chemerin levels in diet-induced obese mice. We divided 40 mice into 4 groups: high-fat diet/exercise, high-fat diet/sedentary, normal diet/exercise, and normal diet/sedentary. A 9-week dietary intervention was followed by a 12-week exercise intervention (treadmill run: 11 m/min for 30 min, 3×/week). We analyzed blood samples before and after the exercise intervention. We used t-tests and linear regression to examine changes in chemerin, insulin resistance, and inflammatory markers, and associations between changes in chemerin and all other biomarkers. Chemerin increased significantly across all mice over the 12-week intervention (mean ± SD = 40.7 ± 77.8%, p = 0.01), and this increase was smaller in the exercise versus sedentary mice (27.2 ± 83.9% versus 54.9 ± 70.5%, p = 0.29). The increase among the high-fat diet/exercise mice was ~44% lower than the increase among the high-fat diet/sedentary mice (55.7 ± 54.9% versus 99.8 ± 57.7%, p = 0.12). The high-fat diet mice showed significant increases in insulin (773.5 ± 1286.6%, p HOMA-IR; 846.5 ± 1723.3%, p HOMA-IR. Chronic exercise may attenuate diet-driven increases in circulating chemerin, and the insulin resistance associated with a high-fat diet may be mediated by diet-induced increases in chemerin.

  10. La Supervisión Educativa: fundamentos epistemológicos de un modelo teórico de su dirección

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    Arismendis Tamayo Pupo

    2011-01-01

    Full Text Available Aborda la temática referida a la supervisión educativa y los principales fundamentos epistemológicos que sustentan la propuesta de un modelo teórico de su dirección. A partir de las insuficiencias constatadas, vinculadas a la concepción actual de la supervisión educativa y su dirección, desde las estructuras jerárquicas superiores que interactúan con las instituciones escolares, se presentan aquellos fundamentos epistemológicos considerados esenciales, de un modelo teórico de la dirección de la supervisión educativa, propugnados desde la Pedagogía como ciencia de la educación, las herramientas metodológicas que brinda la Dirección Científica Educacional, las concepciones referidas a la formación permanente de docentes y directivos y la Teoría General de Sistemas.

  11. Primer "Entrenamiento en Metodologías de Investigación Clínica en Chile" (EMIC-Chile: Fundamentos psicoeducativos

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    B. Cabieses

    Full Text Available EMIC-Chile ("Entrenamiento en Metodologías para la Investigación Clínica en Chile" es un proyecto académico desarrollado durante el año 2008 en Chile para entrenar a profesionales de la salud y disciplinas afines en metodología de investigación clínica, con el objetivo de aumentar la calidad de los proyectos de investigación con fines concursables en nuestro país. El propósito de este artículo es dar a conocer el programa y sus fundamentos teóricos de enseñanza-aprendizaje, que estuvieron en la base de la estructura, metodología, evaluación y sistematización del conocimiento entregado. Para ello, primero se describe el programa, la metodología, la evaluación y el seguimiento. Posteriormente se detallan los aspectos psicoeducativos considerados, con especial énfasis en el aprendizaje social y la educación de adultos. Finalmente, se discute en torno a las posibles consideraciones de este programa para futuras intervenciones educativas en investigación en salud en Chile. Se espera que esta experiencia y sus fundamentos educativos sirvan de motor para futuras iniciativas en el área, a favor de la investigación en salud en Chile.

  12. Fundamentos da instrução: breve revisão com enfoque na perspectiva de Elias e Merriam (1984,1995

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    Figueira, Ana Paula Couceiro

    2009-01-01

    Full Text Available Pretende sensibilizar-se os leitores para os modelos conceptuais ou sistemas teóricos explicativos, justificativos ou orientadores, das práticas educativas ou de instrução. Encontramos na literatura diferentes tipologias de perspectivas da aprendizagem/do conhecimento, com ressonâncias ao nível do ensino e da instrução, ou seja, teorias de aprendizagem e da instrução, paradigmas/epistemologicas da Psicologia Educacional, ou orientações paradigmáticas do ensino. Iremos, apenas neste contexto, dar conta da leitura de Elias e Merriam (1984,1995 sore os fundamentos da instrução. O sistema proposto por Elias e Merriam (1984,1995 é bastante estruturado, sistemático, de leitura substancialmente holística e de grande acuidade e actualidade. Estes autores propõem como fundamentos filosóficos da educação, seis (6 sistemas maiores do pensamento educacional: a educação liberal, a educação progressista (progressive education, o bechaviorismo, a educação humanista, a educação radical e a análise conceptual

  13. La asignatura virtual: Fundamentos de Cirugía en Internet The virtual lecture: Fundamentals of surgery in the Internet

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    Felip Pi

    2004-03-01

    Full Text Available Introducción: Internet permite desarrollar un nuevo modelo de clase teórica basado en la enseñanza nopresencial y asincrónica. Objetivo: Publicación virtual de un tema de "Fundamentos de Cirugía" y evaluación de los resultados de uso y participación de los 80 alumnos matriculados. Material y Métodos: Se diseñaron tres partes: teoría, cuestionario de autoevaluación, y foro de preguntas. La teoría consistía en hipertexto y gráficos, con cuatro tipos de asistentes de aprendizaje: 1 remarcadores de información esencial; 2 información no esencial adicional; 3 mnemotécnicos; 4 ampliación conceptos complejos. El cuestionario consistía en diez preguntas. La pantalla de respuesta ofrecía las respuestas correctas comentadas, la puntuación del alumno, y los centiles de cada nota. El foro de preguntas se basaba en el servidor Ez-Board. El profesor sólo explicó el sistema y los aspectos principales de la lección. Los alumnos podían consultar el material indefinidamente y el foro de preguntas estuvo activo durante dos meses. Resultados: El sistema facilitó la clase por parte del profesor y fue muy bien recibida por los alumnos. Se contabilizaron 239 visitas en dos meses, originadas en la Universidad en 80% de los casos. 16 alumnos usaron el asistente interactivo explicativo. El cuestionario fue respondido por 52 alumnos: 36 alumnos 1 vez y 16 alumnos 2 o más veces. El foro recibió 337 visitas. Se hicieron 38 preguntas de alumnos y 46 respuestas del profesor y otros especialistas. Conclusiones: 1 Diseño y funcionamiento correcto; 2 Excelente acogida y participación; 3 Probable mejora en el aprendizaje y adquisición de conocimientos.Background: Internet resources allow the development of a new theoretical lecture model based on an on-line, asynchronous teaching method. Objective: To evaluate a virtual case presentation related to the undergraduate course "Fundamentals of surgery" through an assessment of its use by the eighty

  14. Fundamentos y aplicaciones del diseño de casos cruzados Case-crossover design: Basic essentials and applications

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    Eduardo Carracedo-Martínez

    2009-04-01

    Full Text Available El diseño de casos cruzados es un diseño epidemiológico observacional propuesto por Maclure en 1991 para valorar si alguna exposición intermitente o inusual ha desencadenado un evento agudo a muy corto plazo. En este trabajo se presentan los fundamentos de los diseños de casos cruzados, con sus aplicaciones y limitaciones. El diseño de casos cruzados se basa en seleccionar sólo sujetos caso. Para calcular el riesgo relativo se compara la exposición durante el periodo de tiempo previo al evento (periodo caso con la exposición del mismo sujeto en uno o varios periodos control. Este método únicamente es adecuado cuando las exposiciones son cambiantes en el tiempo, con efectos a corto plazo, y el efecto es agudo. Para exposiciones en que no existe tendencia, el planteamiento unidireccional es el más frecuente, y consiste en seleccionar uno o varios periodos control previos al momento caso. Cuando la exposición tiene una tendencia temporal (por ejemplo las de contaminación atmosférica, el planteamiento unidireccional proporciona estimaciones sesgadas, por lo que se utilizan diseños de casos cruzados bidireccionales, que seleccionan periodos de tiempo control anteriores y posteriores al del evento. Es un método que cuenta con una creciente utilización en amplios campos: desencadenantes de accidentes de tráfico, laborales y domésticos, o de infarto agudo de miocardio, contaminación atmosférica y salud, farmacoepidemiología, etc. Para el análisis de datos, generalmente se pueden considerar los diseños de casos cruzados como estudios de casos y controles emparejados, por lo que se aplica regresión logística condicional. Finalmente, en este trabajo se analizan ejemplos prácticos de diferentes aplicaciones del diseño de casos cruzados.Case-crossover analysis is an observational epidemiological design that was proposed by Maclure in 1991 to assess whether a given intermittent or unusual exposure may have triggered an immediate

  15. Effects of Dioscorea esculenta and Eubacterium rectale on insulin receptor substrate 1 (Irs1 Expression in skeletal muscle and homeostatic model assessment-insulin resistance (HOMA-IR in diabetic rats

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    . Sunarti

    2017-01-01

    Full Text Available Low expression of insulin receptor substrate 1 (Irs1 is associated with insulin resistance and type 2 diabetes mellitus (type 2 DM. This study was performed to evaluate the effects of Dioscorea esculenta and Eubacterium rectale on the Irs1 expression in the skeletal muscle and the homeostatic model assessment-insulin resistance (HOMA-IR of diabetic rats. Twenty-five male Wistar rats were divided into five groups i.e. non diabetic rats Group 1; diabetic rats as Group 2; diabetic rats + D. esculenta as Group 3; diabetic rats + E.rectale as Group 4 and diabetic rats + both E. rectale and D. esculenta as Group 5. Rats were made diabetic with induction of intraperitoneally injection of nicotinamide and streptozotocin. After four weeks of the interventions, the blood and skeletal muscles were taken. The Irs1 expression was analyzed with immunohistochemical staining, plasma glucose levels was analyzed using a spectrophotometer, and insulin was analyzed using ELISA methods. All intervention groups reduced plasma glucose levels and HOMA-IRs (p<0.001 and increased Irs1 expression. The greatest reduction of  plasma glucose levels and increase of Irs1 expression in the skeletal muscle were found in Group 4, however, the lowest of HOMA-IR was seen in Group 5. These results suggested that D.esculenta, E.rectale, and the combination reduced plasma glucose levels and HOMA-IR by increasing Irs1 expression in skeletal muscle.

  16. The surgical treatment of type II diabetes mellitus: changes in HOMA Insulin resistance in the first year following laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB).

    Science.gov (United States)

    Ballantyne, Garth H; Wasielewski, Annette; Saunders, John K

    2009-09-01

    Bariatric operations significantly improve glucose metabolism, decrease insulin resistance, and lead to clinical resolution of type II diabetes mellitus in many patients. The mechanisms that achieve these clinical outcomes, however, remain ill defined. Moreover, the relative impact of various operations on insulin resistance remains vigorously contested. Consequently, the purpose of this study was to compare directly the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB) on hemoglobin A1c (HbA1c) levels and insulin resistance in comparable groups of morbidly obese patients. Data were entered prospectively into our bariatric surgery database and reviewed retrospectively. Patients selected operations. Principle outcome variables were percent excess weight loss (%EWL), HbA1c, and homeostatic model assessment for insulin resistance (HOMA IR). The number of follow-up visits for 111 LAGB patients was 263 with a median of 162 days (17-1,016) and 291 follow-up visits for 104 LRYGB patients for a median of 150 days (8-1,191). Preoperative height, weight, body mass index, age, sex, race, comorbidities, fasting glucose, insulin, HbA1c, and HOMA IR were similar for both groups. In particular, the number of patients who were diabetics and those receiving insulin and other hypoglycemic agents were similar among the two groups. The LAGB patients lost significantly less weight than the LRYGB patients (24.6% compared to 44.0% EWL). LAGB reduced HbA1c from 5.8% (2-13.8) to 5.6% (0.3-12.3). LRYGB reduced HbA1c from 5.9% (2.0-12.3) to 5.4% (0.1-9.8). LAGB reduced HOMA IR from 3.6 (0.8-39.2) to 2.3 (0-55) and LRYGB reduced HOMA IR from 4.4 (0.6-56.5) to 1.4 (0.3-15.2). Postoperative HOMA IR correlated best with %EWL. Indeed, regression equations were essentially identical for LAGB and LRYGB for drop in %EWL versus postoperative HOMA IR. Percent excess weight loss significantly predicts postoperative insulin resistance (HOMA IR

  17. Determinación de la sensibilidad a la insulina usando el método HOMA en poblaciones adultas habitantes de grandes alturas y a nivel del mar

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    Rossana BARACCO MAGGI

    2006-10-01

    Full Text Available Estudios previos han propuesto que el nativo de altura tiene una mayor sensibilidad a la insulina. El HOMA mide la sensibilidad a la insulina y ha encontrado gran aceptación en estudios poblacionales. Objetivos: Determinar y comparar la sensibilidad a la insulina mediante el método HOMA en una población de grandes alturas y en una población del nivel del mar. Materiales y Métodos: Se realizó un estudio descriptivo y comparativo de dos poblaciones, San Pedro de Cajas (SPC (4 100 msnm y Rímac (nivel del mar. Se estudiaron 254 sujetos, 90 de SPC (60 mujeres y 30 hombres y 164 del Rímac (60 hombres y 104 mujeres. Se midió peso, talla, IMC, glucosa, insulina basal y el HOMA. Resultados: Los niveles de insulina de SPC fueron menores que los del Rímac (5,19 vs. 14,47 uU/ml; p < 0,001. Al dividirlos según género, tanto los hombres (4,56 vs. 12,80 uU/ml; p < 0,001 como las mujeres de SPC (5,51 vs. 15,43 uU/ml; p < 0,001 presentaron una insulinemia menor que los del Rímac. El HOMA de SPC fue menor que el del Rímac (1,14 vs 3,53 uU/ml x mmol/l; p < 0,05. Al dividirlos según género, tanto hombres como las mujeres de SPC presentaron un HOMA menor que los del Rímac. Hubo una correlación entre el HOMA y el IMC, peso e insulinemia de ambas poblaciones. Conclusión: El nativo de altura presenta valores inferiores de insulina basal y de HOMA que el habitante a nivel del mar como consecuencia de una mayor sensibilidad a la insulina endógena, posiblemente condicionado por cambios metabólicos debido a la hipoxia ambiental. El envejecimiento en el habitante del nivel del mar conlleva a una disminución en su sensibilidad a la insulina, mientras que esto no fue demostrado para el nativo de altura. (Rev Med Hered 2006;17:206-211.

  18. A meta-analysis of the effect of angiotensin receptor blockers and calcium channel blockers on blood pressure, glycemia and the HOMA-IR index in non-diabetic patients.

    Science.gov (United States)

    Yang, Yue; Wei, Ri-bao; Xing, Yue; Tang, Lu; Zheng, Xiao-yong; Wang, Zi-cheng; Gao, Yu-wei; Li, Min-xia; Chen, Xiang-mei

    2013-12-01

    This study compared the efficacy of angiotensin receptor blockers (ARBs) and calcium channel blockers (CCBs) in the effect of insulin resistance (IR) as assessed using the homeostasis model assessment of insulin resistance (HOMA-IR) in non-diabetic patients. The MEDLINE, EMBASE, and Cochrane Library databases were searched to identify studies published before December 2012 that investigated the use of ARBs and CCBs to determine the effect on the HOMA-IR index in non-diabetics. Parameters on IR and blood pressure were collected. Review Manager 5.2 and Stata 12.0 were used to perform the meta-analysis. Fixed and random effects models were applied to various aspects of the meta-analysis, which assessed the therapeutic effects of the two types of drug using the HOMA-IR index in non-diabetic patients. The meta-analysis included five clinical trials. Patient comparisons before and after treatment with ARBs and CCBs revealed that ARBs reduced the HOMA-IR index (weighted mean difference (WMD) -0.65, 95% confidence interval (CI) -0.93 to -0.38) and fasting plasma insulin (FPI) (WMD -2.01, 95% CI -3.27 to -0.74) significantly more than CCBs. No significant differences in the therapeutic effects of these two types of drug on blood pressure were observed. Given that there are no significant differences in the therapeutic effects of ARBs and CCBs on blood pressure, as ARBs are superior to CCBs in their effect on the HOMA-IR index in non-diabetics, they might be a better choice in hypertension patients without diabetes. © 2013.

  19. Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese.

    Science.gov (United States)

    Lee, C H; Shih, A Z L; Woo, Y C; Fong, C H Y; Leung, O Y; Janus, E; Cheung, B M Y; Lam, K S L

    The optimal reference range of homeostasis model assessment of insulin resistance (HOMA-IR) in normal Chinese population has not been clearly defined. Here we address this issue using the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS), a prospective population-based cohort study with long-term follow-up. In this study, normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) were defined according to the 1998 World Health Organization criteria. Dysglycemia referred to IFG, IGT or T2DM. This study comprised two parts. Part one was a cross-sectional study involving 2,649 Hong Kong Chinese subjects, aged 25-74 years, at baseline CRISPS-1 (1995-1996). The optimal HOMA-IR cut-offs for dysglycemia and T2DM were determined by the receiver-operating characteristic (ROC) curve. Part two was a prospective study involving 872 subjects who had persistent NGT at CRISPS-4 (2010-2012) after 15 years of follow-up. At baseline, the optimal HOMA-IR cut-offs to identify dysglyceia and T2DM were 1.37 (AUC = 0.735; 95% confidence interval [CI] = 0.713-0.758; Sensitivity [Se] = 65.6%, Specificity [Sp] = 71.3%] and 1.97 (AUC = 0.807; 95% CI = 0.777-0.886; Se = 65.5%, Sp = 82.9%) respectively. These cut-offs, derived from the cross-sectional study at baseline, corresponded closely to the 75th (1.44) and 90th (2.03) percentiles, respectively, of the HOMA-IR reference range derived from the prospective study of subjects with persistent NGT. HOMA-IR cut-offs, of 1.4 and 2.0, which discriminated dysglycemia and T2DM respectively from NGT in Southern Chinese, can be usefully employed as references in clinical research involving the assessment of insulin resistance.

  20. Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: Developments in research and prospects for the future.

    Science.gov (United States)

    Tang, Qi; Li, Xueqin; Song, Peipei; Xu, Lingzhong

    2015-12-01

    Diabetes mellitus (DM) appears to be increasing rapidly, threatening to reduce life expectancy for humans around the globe. The International Diabetes Federation (IDF) has estimated that there will be 642 million people living with the disease by 2040 and half as many again who will be not diagnosed. This means that pre-DM screening is a critical issue. Insulin resistance (IR) has emerged as a major pathophysiological factor in the development and progression of DM since it is evident in susceptible individuals at the early stages of DM, and particularly type 2 DM (T2DM). Therefore, assessment of IR via the homeostasis model assessment of IR (HOMA-IR) is a key index for the primary prevention of DM and is thus found in guidelines for screening of high-risk groups. However, the cut-off values of HOMA-IR differ for different races, ages, genders, diseases, complications, etc. due to the complexity of IR. This hampers the determination of specific cut-off values of HOMA-IR in different places and in different situations. China has not published an official index to gauge IR for primary prevention of T2DM in the diabetic and non-diabetic population except for children and adolescents ages 6-12 years. Hence, this article summarizes developments in research on IR, HOMA-IR, and pre-DM screening in order to provide a reference for optimal cut-off values of HOMA-IR for the diagnosis of DM in the Chinese population.

  1. Fibroblast Growth Factor 21 (FGF21, Free Fatty Acid (FFA, High Sensitivity C-reactive Protein (hsCRP and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR Among Indonesian Obese Non-Diabetic Males

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    Yani Lina

    2009-12-01

    Full Text Available BACKGROUND: Fibroblast growth factor-21 (FGF21 is known as an important endocrine and paracrine regulator of metabolic homeostasis. Recent studies have shown that FGF21 attenuates lipolysis in human adipocytes, which is suggested as a FGF21's mechanism as anti-hyperlipidemia, anti-hyperglycemia and anti-obesity. The aim of this study was to measure the correlation between FGF21, FFA, hsCRP and HOMA-IR among Indonesian obese non diabetic males. METHODS: The study was observational with cross sectional design. The analysis was done in 137 subjects aged 30-60 years with non diabetic abdominal obesity. We measured the biochemical markers FGF21, FFA, hsCRP, fasting insulin and fasting glucose. We also measured weight, height, waist circumrefence (WC, creatinine, serum glutamin oxaloacetic transaminase (SGOT, and serum glutamic pyruvic transaminase (SGPT, systolic blood pressure (SBP and diastolic blood pressure (DBP. Correlation between markers was measured using Pearson and Spearman's analysis. RESULTS: There were significant positive correlations between FGF21-HOMA-IR (r=0.314, p=0.000; FGF21-WC (r=0.173, p=0.043; FFA=hsCRP r=0.270, p=0.001; and WC-HOMA-IR (r=0.279, p=0.001. There was significant negative correlation between FGF21-FFA (r=-0.038, p=0.657 and FGF21-hsCRP (r=-0.061, p=0.482. CONCLUSIONS: In this study we found that although there was no significant correlation, FGF21 might act as an anti-lipolytic and anti-inflammation agent among Indonesian obese non-diabetic males. Our findings agree with results of previous studies that the positive correlation between FGF21-WC and FGF21-HOMA-IR might occur as a compensatory mechanism or resistance to FGF21 in obesity. KEYWORDS: obesity, FGF21, FFA, hsCRP, HOMA-IR.

  2. Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS.

    Science.gov (United States)

    Peplies, Jenny; Börnhorst, Claudia; Günther, Kathrin; Fraterman, Arno; Russo, Paola; Veidebaum, Toomas; Tornaritis, Michael; De Henauw, Stefaan; Marild, Staffan; Molnar, Dénes; Moreno, Luis A; Ahrens, Wolfgang

    2016-09-02

    This study investigates prospective associations of anthropometrical and lifestyle indices with insulin resistance (IR) in European children from the IDEFICS cohort. Insulin resistance (IR) is a growing concern in childhood obesity and a central aspect of the metabolic syndrome (MS). It most likely represents the link between obesity and type 2 diabetes. This longitudinal study included 3348 preadolescent children aged 3 to 10.9 years from 8 European countries who were observed from 2007/2008 to 2009/2010. The main outcome measure in the present analysis is HOMA-IR (homeostasis model assessment as a common proxy indicator to quantify IR) at follow-up and in its longitudinal development. Anthropometrical measures and lifestyle indices, including objectively determined physical activity, were considered, among others factors, as determinants of IR. Prospective associations between IR at follow-up and anthropometrical and lifestyle indices were estimated by logistic regression models. Country-specific prevalence rates of IR in the IDEFICS cohort of European children showed a positive trend with weight category. Prospective multivariate analyses showed the strongest positive associations of IR with BMI z-score (OR = 2.6 for unit change from the mean, 95 % CI 2.1-3.1) and z-score of waist circumference (OR = 2.2 for unit change from the mean, 95 % CI 1.9-2.6), which were analysed in separate models, but also for sex (OR = 2.2 for girls vs. boys, 95 % CI 1.5-3.1 up to OR 2.5, 95 % CI 1.8-3.6 depending on the model), audio-visual media time (OR = 1.2 for an additional hour per day, 95 % CI 1.0-1.4 in both models) and an inverse association of objectively determined physical activity (OR = 0.5 for 3(rd) compared to 1(st) quartile, 95 % CI 0.3-0.9 in both models). A longitudinal reduction of HOMA-IR was accompanied with a parallel decline in BMI. This study is, to our knowledge, the first prospective study on IR in a preadolescent children

  3. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance.

    Science.gov (United States)

    Lin, Po-Ju; Borer, Katarina T

    2016-01-01

    Postprandial hyperinsulinemia, hyperglycemia, and insulin resistance increase the risk of type 2 diabetes (T2D) and cardiovascular disease mortality. Postprandial hyperinsulinemia and hyperglycemia also occur in metabolically healthy subjects consuming high-carbohydrate diets particularly after evening meals and when carbohydrate loads follow acute exercise. We hypothesized the involvement of dietary carbohydrate load, especially when timed after exercise, and mediation by the glucose-dependent insulinotropic peptide (GIP) in this phenomenon, as this incretin promotes insulin secretion after carbohydrate intake in insulin-sensitive, but not in insulin-resistant states. Four groups of eight metabolically healthy weight-matched postmenopausal women were provided with three isocaloric meals (a pre-trial meal and two meals during the trial day) containing either 30% or 60% carbohydrate, with and without two-hours of moderate-intensity exercise before the last two meals. Plasma glucose, insulin, glucagon, GIP, glucagon-like peptide 1 (GLP-1), free fatty acids (FFAs), and D-3-hydroxybutyrate concentrations were measured during 4-h postprandial periods and 3-h exercise periods, and their areas under the curve (AUCs) were analyzed by mixed-model ANOVA, and insulin resistance during fasting and meal tolerance tests within each diet was estimated using homeostasis-model assessment (HOMA-IR). The third low-carbohydrate meal, but not the high-carbohydrate meal, reduced: (1) evening insulin AUC by 39% without exercise and by 31% after exercise; (2) GIP AUC by 48% without exercise and by 45% after exercise, and (3) evening insulin resistance by 37% without exercise and by 24% after exercise. Pre-meal exercise did not alter insulin-, GIP- and HOMA-IR- lowering effects of low-carbohydrate diet, but exacerbated evening hyperglycemia. Evening postprandial insulin and GIP responses and insulin resistance declined by over 30% after three meals that limited daily carbohydrate intake to

  4. Pedagogia Salesiana: O Oratório festivo como princípio e fundamento da educação salesiana (p. 145-159)

    OpenAIRE

    de Souza, Rodrigo Tarcha Amaral

    2015-01-01

    Com a intenção de apresentar os conceitos referentes ao Oratório festivo como princípio e fundamento da Educação salesiana, o artigo, por meio de referencial teórico historicista e analítico, traz reflexões, conjecturas e hipóteses acerca dos pontos convergentes e divergentes entre a tradição salesiana e a atual operacionalização dos Oratórios festivos. Além de promover o diálogo da afirmação institucional, ou não, dos atuais Oratórios. O artigo apresenta ainda, já numa perspectiva conclusiva...

  5. Das margens para o centro: Mudanças na pesquisa em fundamentos da mecânica quântica, 1950-1990

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    Olival Freire Junior

    2015-07-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2015v32n2p369 A pesquisa em fundamentos da teoria quântica experimentou mudanças dramáticas na segunda metade do século XX, tendo evoluído de uma posição marginal na agenda de pesquisa da física para uma posição muito bem valorizada. Nós examinamos o conjunto de fatores, internos e externos, que condicionaram esta mudança. Especial atenção foi prestada à atividade dos físicos que foram os protagonistas destas mudanças, os quais nós denominamos de dissidentes quânticos.

  6. Concepción del bien común en el pensamiento de Salvador Cisneros Betancourt: fundamento ético de un pensamiento político

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    Lic. Yudith Sotomayor-Gil

    2015-10-01

    Full Text Available Este trabajo se centra en el tratamiento teórico y desarrollo histórico de la categoría ética de bien común y su presencia, como fundamento, en el pensamiento político de Salvador Cisneros Betancourt, figura notoria y controversial de la historia de Cuba. Este tema, que se revela como continuidad de la tradición ética en que se sostiene el pensamiento cubano desde su momento fundacional, no ha recibido un tratamiento sistemático en la literatura filosófica cubana actual. El análisis de los documentos, en especial los que se inscriben entre 1902 y 1914, permite apreciar que, aunque no la aborde de forma explícita, la concepción del bien común permea el quehacer intelectual de Cisneros en esos años.

  7. A ressemantização do Fundamento em Theodor W. Adorno [The ressemantization of the foundation in Theodor W. Adorno

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    Francisco Luciano Teixeira Filho

    2017-08-01

    Full Text Available Apresenta-se a tese da ressemantização do conceito de fundamento em Adorno (1903–1969. Através de análise bibliográfica e teórica, pretende-se demonstrar como é possível pensar a fundamentação numa filosofia marcada, essencialmente, pelo fracasso do projeto iluminista recente. [This paper presents the thesis of the resemantization of the concept of foundation in Adorno (1903-1969. Through bibliographical and theoretical analysis, it is intended to demonstrate how it is possible to think the foundation in a philosophy marked, essentially, by the failure of recent Enlightenment project.

  8. Prensa, justicia y producción narrativa del poder: fundamentos teórico-metodológicos para un estudio comparado del discurso

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    Carlos Del Valle Rojas

    2010-01-01

    Full Text Available El presente artículo tiene por objetivo principal exponer las articulaciones teóricas que sustentan el estudio acerca de los discursos jurídico-judiciales y de la prensa en Chile como práctica específica empleada por algunos actores (jueces y periodistas de la sociedad, para definir tipos de subjetividad y formas de saber, poder y verdad. Se pretende describir los fundamentos teóricos centrales del proyecto de investigación Fondecyt núm. 1090108, cuyo propósito es comprender las distintas relaciones entre los discursos narrativos factuales (de los hechos y de poder producidos por los medios de comunicación social (noticias policiales y los tribunales de justicia (sentencias penales.

  9. Plasma vitamin D is associated with fasting insulin and HOMA-IR in young adult males, but not females, of the Jerusalem Perinatal Study

    Science.gov (United States)

    Moore, Amy; Hochner, Hagit; Sitlani, Colleen M; Williams, Michelle A; Hoofnagle, Andrew N; de Boer, Ian H; Kestenbaum, Bryan; Siscovick, David S; Friedlander, Yechiel; Enquobahrie, Daniel A

    2015-01-01

    Objective To examine cross-sectional relationships between plasma vitamin D and Cardiometabolic Risk Factors in young adults. Design Data were collected from interviews, physical examinations, and biomarker measurements. Total plasma 25-hydroxyvitamin D (25[OH]D) was measured using liquid chromatography-tandem mass spectrometry. Associations between 25[OH]D and CMR were modeled using weighted linear regression with robust standard error estimates. Setting Individuals born in Jerusalem during 1974-1976. Subjects Participants of the Jerusalem Perinatal Study (n = 1,204) interviewed and examined at age 32 years. Participants were oversampled for low and high birthweight and for maternal pre-pregnancy obesity. Results Mean total 25[OH]D concentration among participants was 21.7 ng/mL (SD 8.9). Among males, 25[OH]D was associated with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (natural log-transformed, β = -0.011, p = 0.004) after adjustment for body mass index. However, these associations were not present among females (p for sex interaction = 0.005). Conclusions We found evidence for inverse associations of 25[OH]D with markers of insulin resistance among males, but not females, in a health, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex specific effects of vitamin D on CMR are warranted. PMID:25145881

  10. Swim Training Improves HOMA-IR in Type 2 Diabetes Induced by High Fat Diet and Low Dose of Streptozotocin in Male Rats.

    Science.gov (United States)

    Ghiasi, Rafigheh; Ghadiri Soufi, Farhad; Somi, Mohammad Hossein; Mohaddes, Gisou; Mirzaie Bavil, Fariba; Naderi, Roya; Alipour, Mohammad Reza

    2015-09-01

    Insulin resistance plays a key role in the onset and development of type 2 diabetes mellitus (T2DM) and its complications. In this study, we evaluated the effect of swim training on insulin resistance in diabetic rats. Forty male Wistar rats were randomly divided into four groups (n=10): sedentary control (Con), sedentary diabetic (Dia), swim trained control (Exe) and swim trained diabetic (Dia+Exe) rats. Diabetes was induced by high fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, i.p). In trained groups, one week after the induction of diabetes, animals were subjected to swimming (60 min/5 days a week) for 10 weeks. At the end of training, fasting blood sugar (FBS), oral glucose tolerance test (OGTT), fasting/basal insulin, glycosylated hemoglobin (HbA1c) levels, insulin resistance index, homeostasis model assessment method (HOMA-IR), triglycerides (TG,) total cholesterol (TCh), and high density lipoprotein (HDL) levels in blood were measured. Swimming significantly improved OGTT (PHOMA-IR (P<0.01). Swim training also significantly decreased FBS (p<0.01), fasting/basal insulin (P<0.01), HbA1C (p<0.01), TG (P<0.05), and TCh (P<0.05) levels. It also significantly increased HDL (p<0.05) level. Our findings indicate that swim training improved glycemic control and insulin sensitivity in type 2 diabetes caused by high fat diet in male rats.

  11. The effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA-IR) in sedentary obese women.

    Science.gov (United States)

    Zehsaz, Farzad; Farhangi, Negin; Mirheidari, Lamia

    2014-01-01

    The purpose of the present study was to investigate the effects of a 12-week training program on serum CXC ligand 5, tumor necrosis factor α (TNF-α) and insulin resistance index in obese sedentary women. To this end, twenty-four obese sedentary women were evaluated before and after a 12-week exercise program including a brief warm-up, followed by ~45 min per session of aerobic exercise at an intensity of 60-75% of age-predicted maximum heart rate (~300 kcal/day), followed by a brief cool down, five times per week. After the exercise program, body weight, waist circumference, waist to hip ratio, percentage body fat mass, fasting glucose and insulin of participants were decreased. Furthermore, serum CXCL5 levels were significantly decreased from 2693.2 ±375.8 to 2290.2 ±345.9 pg/ml (p HOMA-IR (p < 0.001) and TNF-α (p < 0.001). Exercise training induced weight loss resulted in a significant reduction in serum CXCL5 concentrations and caused an improvement in insulin resistance in obese sedentary women.

  12. La dimensión ambiental en la disciplina Fundamentos Filosóficos de la Educación Física y el Deporte

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    Mayra Fonseca Carvajal

    2009-12-01

    Full Text Available El deporte es la faceta de la actividad humana que mayor crecimiento ha tenido en estas últimas décadas, se ha incorporado a los hábitos cotidianos de los ciudadanos contemporáneos y es una de las actividades de ocio a las que más tiempo dedican. Como en toda actividad humana se interactúa con el entorno, con los elementos naturales y produce impactos ambientales. Constituye uno de los retos más importantes de la humanidad compatibilizar la práctica deportiva con la preservación de los valores y recursos naturales, es una cuestión de supervivencia y como demostró la Conferencia de las Naciones Unidas para el Medio Ambiente y el Desarrollo, Río´92, es una tarea que a todos nos atañe. El mensaje debe ser que el que realmente es un buen deportista cuida de su entorno y es responsable de sus actos por lo que resulta de vital importancia la educación ambiental a través de las diferentes asignaturas en la Escuela Internacional de Educación física por lo que los profesores de la disciplina Fundamentos Filosóficos y Socio Históricos de la Educación Física y el Deporte conceden especial atención a la educación ambiental y al adecuado vínculo entre deporte y medioambiente en el tratamiento de los contenidos que tributa al desarrollo sostenible .Con el presente trabajo pretendemos ejemplificar la dimensión ambiental en la disciplina Fundamentos Filosóficos de la EIEFD como una vía que contribuye al desarrollo sostenible en los profesionales de la institución.

  13. Insulin resistance index (HOMA-IR in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals Índice de resistência insulínica (HOMA-IR na diferenciação entre pacientes com doença hepática gordurosa não-alcoólica e indivíduos saudáveis

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    Ana Lúcia Farias de Azevedo Salgado

    2010-06-01

    Full Text Available CONTEXT: Due to its good correlation to glycemic clamp, HOMA-IR has been widely utilized as insulin resistance index in clinical and epidemiological studies involving non-alcoholic fatty liver disease carriers. However, values used for this parameter have shown large variability. OBJECTIVE: To identify the HOMA-IR cut value that best distinguishes non-diabetic non-alcoholic fatty liver disease patients from a control group. METHODS: One hundred sixteen non-alcoholic fatty liver disease patients were studied, diagnosed by clinical, biochemical, and liver image or biopsy criteria, and 88 healthy individuals, without any liver disease and testing for oral glucose tolerance within normality. These groups did not differ in age and gender. All were submitted to oral glucose tolerance test and blood samples were collected for glucose and insulin measurements by immunofluorometric method. HOMA-IR was calculated according to the formula: fasting insulin (µU/L x fasting glucose (nmol/L/22.5. RESULTS: NAFLD patients showed higher insulin, glycemia, and HOMA-IR values than control group, even when excluding glucose intolerant and diabetes mellitus patients by their glycemic curves. HOMA-IR 75th percentile for control group was 1.78 and the best area under the curve index was obtained for HOMA-IR values of 2.0 [AUC= 0.840 (0.781-0.899 CI 95%, sensitivity (Se: 85%, specificity (Sp: 83%] while value 2.5 showed best specificity without important loss in sensitivity [AUC=0,831 (0.773-0.888 Se = 72%, Sp = 94%]. CONCLUSION: HOMA-IR values above or equal to 2.0 or 2.5 show enhanced diagnostic value in distinguishing non-alcoholic fatty liver disease carriers from control group individuals.CONTEXTO: Pela sua boa correlação com o "clamp" glicêmico, o HOMA-IR tem sido largamente utilizado como índice de resistência insulínica em estudos clínicos e epidemiológicos em pacientes com doença hepática gordurosa não-alcoólica. Porém os valores utilizados para

  14. Diet-induced increases in chemerin are attenuated by exercise and mediate the effect of diet on insulin and HOMA-IR

    Science.gov (United States)

    Lloyd, Jesse W.; Zerfass, Kristy M.; Heckstall, Ebony M.; Evans, Kristin A.

    2015-01-01

    Objectives: Chemerin concentrations are elevated in obesity and associated with inflammation and insulin resistance. Exercise improves insulin sensitivity, which may be facilitated by changes in chemerin. We explored the effects of chronic exercise on chemerin levels in diet-induced obese mice. Methods: We divided 40 mice into 4 groups: high-fat diet/exercise, high-fat diet/sedentary, normal diet/exercise, and normal diet/sedentary. A 9-week dietary intervention was followed by a 12-week exercise intervention (treadmill run: 11 m/min for 30 min, 3×/week). We analyzed blood samples before and after the exercise intervention. We used t-tests and linear regression to examine changes in chemerin, insulin resistance, and inflammatory markers, and associations between changes in chemerin and all other biomarkers. Results: Chemerin increased significantly across all mice over the 12-week intervention (mean ± SD = 40.7 ± 77.8%, p = 0.01), and this increase was smaller in the exercise versus sedentary mice (27.2 ± 83.9% versus 54.9 ± 70.5%, p = 0.29). The increase among the high-fat diet/exercise mice was ~44% lower than the increase among the high-fat diet/sedentary mice (55.7 ± 54.9% versus 99.8 ± 57.7%, p = 0.12). The high-fat diet mice showed significant increases in insulin (773.5 ± 1286.6%, p diet-induced increases in insulin and HOMA-IR. Conclusion: Chronic exercise may attenuate diet-driven increases in circulating chemerin, and the insulin resistance associated with a high-fat diet may be mediated by diet-induced increases in chemerin. PMID:26445641

  15. Definition of insulin resistance using the homeostasis model assessment (HOMA-IR) in IVF patients diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria.

    Science.gov (United States)

    Alebić, Miro Šimun; Bulum, Tomislav; Stojanović, Nataša; Duvnjak, Lea

    2014-11-01

    Polycystic ovary syndrome (PCOS) women are more insulin resistant than general population. Prevalence data on insulin resistance (IR) in PCOS vary depending on population characteristics and methodology used. The objectives of this study were to investigate whether IR in PCOS is exclusively associated with body mass and to assess the prevalence of IR in lean and overweight/obese PCOS. Study included 250 consecutive women who attended a Department of Human Reproduction diagnosed as having PCOS according to the Rotterdam criteria. Control group comprised 500 healthy women referred for male factor infertility evaluation during the same period as the PCOS women. PCOS women (n = 250) were more insulin resistant than controls (n = 500) even after adjustment for age and body mass index (BMI) (P = 0.03). Using logistic regression analysis, BMI ≥ 25 kg/m(2) (OR 6.0; 95 % CI 3.3-11.0), PCOS (OR 2.2; 95 % CI 1.4-3.5) and waist circumference ≥ 80 cm (OR 2.0; 95 % CI 1.1-3.8) were identified as independent determinants of IR (P IR was more prevalent in overweight/obese controls (n = 100) than in lean PCOS women (n = 150), 31 versus 9.3 %, but less prevalent than in overweight/obese PCOS (n = 100), 31 versus 57 %. The prevalence of IR between lean controls (5 %) and lean PCOS (9.3 %) did not significantly differ. Both PCOS-specific and obesity-related IR independently contribute to IR in PCOS. Using HOMA-IR cutoff value of 3.15 specific for Croatian women in our clinical setting, the assessed prevalence of IR in lean and overweight/obese PCOS women was 9.3 and 57 %, respectively.

  16. PHYSICO-CHEMICAL PARAMETERS ASSESSTMENT OF CHILAR DAM WATER IN DIFFERENT SITES OF SHAJAPUR TOWN, M.P., INDIA

    OpenAIRE

    Bodane Arun Kumar

    2017-01-01

    The present investigation reveals the quality of Dam water for public consumption to determine the Dam water of Shajapur town. Physico-chemical parameters of Dam water were monitored during the study period. The parameters investigated were pH, TDS, Alkalinity, Total Hardness, Chlorides, Magnesium, Fluoride, Nitrates, Dissolve Oxygen and COD. Results obtained from the study revealed that quality of Dam water during study season is well within the permissible limit and the Dam water is safe fo...

  17. Adherence to self-administered tuberculosis treatment in a high HIV-prevalence setting: a cross-sectional survey in Homa Bay, Kenya.

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    Fabienne Nackers

    Full Text Available BACKGROUND: Good adherence to treatment is crucial to control tuberculosis (TB. Efficiency and feasibility of directly observed therapy (DOT under routine program conditions have been questioned. As an alternative, Médecins sans Frontières introduced self-administered therapy (SAT in several TB programs. We aimed to measure adherence to TB treatment among patients receiving TB chemotherapy with fixed dose combination (FDC under SAT at the Homa Bay district hospital (Kenya. A second objective was to compare the adherence agreement between different assessment tools. METHODS: We conducted a cross-sectional survey amongst a series of new TB patients receiving 6 months of standard TB chemotherapy with FDC under SAT. Adherence was assessed at home with urine testing for Isoniazid (INH, pill count, interviewer-administered questionnaire and visual analogue scale (VAS. RESULTS: In November 2008 and in June 2009, 212 of 279 eligible patients were assessed for adherence. Overall, 95.2% [95%CI: 91.3-97.7] of the patients reported not having missed a tablet in the last 4 days. On the VAS, complete adherence was estimated at 92.5% [95%CI: 88.0-95.6]. INH urine test was positive for 97.6% [95%CI: 94.6-99.2] of the patients. Pill count could be assessed among only 70% of the interviewed patients. Among them, it was complete for 82.3% [95%CI: 75.1-88.1]. Among the 212 surveyed patients, 193 (91.0% were successfully treated (cured or treatment completed. The data suggest a fair agreement between the questionnaire and the INH urine test (k = 0.43 and between the questionnaire and the VAS (k = 0.40. Agreement was poor between the other adherence tools. CONCLUSION: These results suggest that SAT, together with the FDC, allows achieving appropriate adherence to antituberculosis treatment in a high TB and HIV burden area. The use of a combination of a VAS and a questionnaire can be an adequate approach to monitor adherence to TB treatment in routine program

  18. La producción social de la diferencia humana como fundamento antropológico de los derechos humanos negativos

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    Terence Turner

    2010-11-01

    Full Text Available Los derechos humanos han sido muy discutidos en muchos contextos académicos, políticos y activistas en los últimos años. La Antropología, que durante mucho tiempo se identificó como críticamente opuesta a la idea de los derechos humanos universales y a la Carta de las Naciones Unidas, ha cambiado recientemente su posición con una declaración revisada sobre derechos humanos que ha sido aprobada por la Asociación Americana de Antropología —AAA—. Este artículo presenta un enfoque innovador para abordar el concepto de los derechos humanos, incluyendo específicamente la relevancia del significado del término “humano”, que subyace y converge con la revisión de los derechos humanos adoptado por la AAA. Siguiendo este enfoque, el artículo desarrolla un concepto negativo de los derechos humanos en combinación con un fundamento positivo, que incluye una comprensión antropológica de lo que significa “humano” a efectos del discurso de los derechos humanos y del activismo.

  19. Variational data assimilation: mathematical foundations and one application Assimilação variacional de dados: fundamentos matemáticos e uma aplicação

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    Paulo S. D. da Silva

    2011-09-01

    Full Text Available Variational Data Assimilation and Adjoint Equation Method are presented here as a general methodology designed to improve the quality of computational simulation when are given the dynamics and a set of observation of the system under study. The mathematical foundations the procedures to obtain the adjoint of a given computational program, a fundamental task in order to apply the methodology, are carefully examined.A Assimilação Variacional de Dados e o método das Equações Adjuntas são aqui apresentados como uma metodologia geral, desenvolvida para melhorar a qualidade das simulações computacionais, quando a dinâmica e um conjunto de observações do sistema em estudo são conhecidos. Os fundamentos matemáticos e os procedimentos para se obter o adjunto de um dado programa computacional, uma tarefa fundamental para a aplicação da metodologia, são cuidadosamente examinados.

  20. Economía política del financiamiento de los estudios universitarios en Chile (1980-2010: debate de sus fundamentos

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    Sebastián Donoso Díaz

    2009-12-01

    Full Text Available En el texto se reflexiona acerca de los fundamentos que desde el punto de vista de la economía política posee el sistema de financiamiento de los estudios universitarios en Chile, caso de relevancia pues desde hace casi tres décadas se han aplicado políticas de financiamiento que asumen costos compartidos entre la sociedad, la familia y las instituciones educacionales, como asimismo se han empleado distintos sistemas de crédito estudiantil. La discusión sigue el racional de la economía política, analizando “la producción de bienes en educación”, identificando las principales demandas hacia la educación y los principios en juego, dando cuenta de los temas pendientes y algunas de sus consecuencias, para lo cual se efectúan ciertas propuestas orientadas a su mitigación. Finalmente se expresa la preocupación por develar un problema que no visualizado aún respecto de los recursos invertidos y sus retornos lo que puede significar una crisis de proporciones, como en su momento (2002 enfrentó Chile a nivel de la enseñanza secundaria

  1. Las Cortes y el gobierno de la oligarquía, 1430-1432: los fundamentos de un nuevo soporte institucional

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    Vicente Ángel Álvarez Palenzuela

    2013-11-01

    Full Text Available Finalizada la guerra con Aragón y Navarra se forma en Castilla un grupo oligárquico que controlará el poder en Castilla en los próximos años. Las Cortes plantean numerosas peticiones para hacer frente a los daños y resolver los graves problemas causados por la guerra; sus consecuencias y los proyectos del equipo gobernante obligan a las ciudades a hacer frente a una pesada carga fiscal. En esas circunstancias los procuradores tratan de defender los intereses de sus ciudades, corregir abusos y corrupciones y, sobre todo, recomponer el reino, recuperar el orden y construir los fundamentos de un verdadero soporte institucional.Once the war with Aragon and Navarre had concluded, an oligarchic group was created to control Castilian politics for the following years. The Cortes (the Castilian parliament issued several petitions to settle damages and resolve serious problems caused by the war. The ensuing consequences of the conflict and the new project of the governing clique forced a heavy tax burden onto the cities. Under these circumstances, parliamentary representatives attempted to defend the interests of the cities, correct abuses and corruption and, above all, rebuild the kingdom, impose order and establish the foundations for an authentic institutional framework.

  2. Revisitar los fundamentos del constructivismo: las bases éticas y religiosas del pensamiento psicopedagógico del joven Piaget

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    Maria FORMOSHINO

    2014-12-01

    Full Text Available El pensamiento de Piaget se basa en un marco conceptual ecléctico integrado por varias líneas teóricas. Así, el presente estudio tiene como objetivo explicitar las bases metafísicas y teológicas del proyecto intelectual del joven Piaget para demostrar la relativa unidad y continuidad entre las categorías forjadas para tratar cuestiones teológicas y éticas y las categorías biopsicopedagógicas, prestando especial atención a la dialéctica inmanencia-trascendencia y conflicto-cooperación. En efecto, si la importancia formativa de las primeras exploraciones biológicas de Piaget ya fue estudiada cuidadosamente, las cuestiones referidas a los fundamentos religiosos o teológicos del pensamiento del joven Piaget en los años 1910-1920 han sido menos desarrolladas. Sin embargo, sostenemos que la elucidación de su ética protestante inmanentista ofrece una valiosa clave hermenéutica para entender la necesidad lógica de la transición de Piaget a la experimentación psicológica y, por lo tanto, a la construcción de conceptos explicativos en la epistemología genética, permitiendo reconocer el valor de la Educación Activa, defendida y praticada en el Instituto J.-J. Rousseau.

  3. ALTERAÇÃO DE UM LAYOUT FUNCIONAL PARA LAYOUT CELULAR MOTIVADO PELOS FUNDAMENTOS DA MANUFATURA ENXUTA: ESTUDO DE CASO EM UMA INDÚSTRIA DE TRANSFORMADORES

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    Felipe Crisóstomo Gadelha

    2015-12-01

    Full Text Available O presente trabalho apresenta o estudo de uma alteração de layout, de funcional para celular, motivado pelos fundamentos da manufatura enxuta. Tendo como objetivo verificar os benefícios de se utilizar a manufatura celular com fluxo enxuto (contínuo, apresenta como metodologia um estudo de caso, pós-fato, em uma indústria de transformadores, onde a mudança foi realizada. Para fundamentar o estudo, apresenta revisão dos temas: Sistema de Manufatura Enxuta e layout industrial, para, em seguida, trazer os dados apresentados por esta indústria, ainda em um arranjo físico funcional, antes da alteração, e, em seguida, nas células de manufatura com um fluxo enxuto, após a alteração, e realizar uma comparação entre ambos. Os resultados obtidos desta comparação apresentam ganhos como aumento de produção, em 20%, e produtividade, em 56%, redução de lead time, em 67%, mão de obra direta, em 30%, tempo de processamento, em 20%, e área fabril, em 24%, dentre outros, evidenciando os benefícios que a utilização de um layout celular e Manufatura Enxuta proporcionam.

  4. Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007).

    Science.gov (United States)

    Esteghamati, Alireza; Ashraf, Haleh; Khalilzadeh, Omid; Zandieh, Ali; Nakhjavani, Manouchehr; Rashidi, Armin; Haghazali, Mehrdad; Asgari, Fereshteh

    2010-04-07

    We have recently determined the optimal cut-off of the homeostatic model assessment of insulin resistance for the diagnosis of insulin resistance (IR) and metabolic syndrome (MetS) in non-diabetic residents of Tehran, the capital of Iran. The aim of the present study is to establish the optimal cut-off at the national level in the Iranian population with and without diabetes. Data of the third National Surveillance of Risk Factors of Non-Communicable Diseases, available for 3,071 adult Iranian individuals aging 25-64 years were analyzed. MetS was defined according to the Adult Treatment Panel III (ATPIII) and International Diabetes Federation (IDF) criteria. HOMA-IR cut-offs from the 50th to the 95th percentile were calculated and sensitivity, specificity, and positive likelihood ratio for MetS diagnosis were determined. The receiver operating characteristic (ROC) curves of HOMA-IR for MetS diagnosis were depicted, and the optimal cut-offs were determined by two different methods: Youden index, and the shortest distance from the top left corner of the curve. The area under the curve (AUC) (95%CI) was 0.650 (0.631-0.670) for IDF-defined MetS and 0.683 (0.664-0.703) with the ATPIII definition. The optimal HOMA-IR cut-off for the diagnosis of IDF- and ATPIII-defined MetS in non-diabetic individuals was 1.775 (sensitivity: 57.3%, specificity: 65.3%, with ATPIII; sensitivity: 55.9%, specificity: 64.7%, with IDF). The optimal cut-offs in diabetic individuals were 3.875 (sensitivity: 49.7%, specificity: 69.6%) and 4.325 (sensitivity: 45.4%, specificity: 69.0%) for ATPIII- and IDF-defined MetS, respectively. We determined the optimal HOMA-IR cut-off points for the diagnosis of MetS in the Iranian population with and without diabetes.

  5. Los fundamentos epistemológicos de la contabilidad y su incidencia en la formación competitiva del contador público

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    Coloníbol Torres Bardales

    2012-06-01

    Full Text Available El presente trabajo tiene como objetivo demostrar que la Contabilidad es una ciencia social, cuyos fundamentos epistemológicos tienen gran importancia en la formación competitiva del contador público y están vinculados a principios, leyes, métodos e hipótesis; elementos que constituyen la estructura de su objeto de estudio y a partir de ellos se sistematiza su teoría. Sin embargo, algunos contadores la consideran como técnica, mientras que otros, como ciencia. Dicha discrepancia se elimina con la epistemología, medio imprescindible para establecer la precisión científica de la Contabilidad. Muchos contadores públicos carecen de preparación epistémica. Su formación profesional es de alto contenido normativo (Normas Internacionales de Información Financiera, US-GAAP, etc., sustentada en experiencias concretas y en la aplicación de leyes y principios para la mejor organización y funcionamiento empresarial, pero sin la base epistemológica ni la aplicación de otros conocimientos que les permitan formarse como investigadores y estar preparados para elaborar y ejecutar proyectos de investigación y obtener resultados de trascendencia científica y social. Los planteamientos formulados servirán como punto de partida para que los profesionales mencionados consideren la epistemología como conocimiento esencial para dar mayor consistencia científica a las áreas que componen la estructura de la ciencia contable y su incidencia en el desarrollo empresarial.

  6. Los fundamentos epistemológicos de la contabilidad y su incidencia en la formación competitiva del contador público

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    Coloníbol Torres Bardales

    2012-07-01

    Full Text Available El presente trabajo tiene como objetivo demostrar que la Contabilidad es una ciencia social, cuyos fundamentos epistemológicos tienen gran importancia en la formación competitiva del contador público y están vinculados a principios, leyes, métodos e hipótesis; elementos que constituyen la estructura de su objeto de estudio y a partir de ellos se sistematiza su teoría. Sin embargo, algunos contadores la consideran como técnica, mientras que otros, como ciencia. Dicha discrepancia se elimina con la epistemología, medio imprescindible para establecer la precisión científica de la Contabilidad. Muchos contadores públicos carecen de preparación epistémica. Su formación profesional es de alto contenido normativo (Normas Internacionales de Información Financiera, US-GAAP, etc., sustentada en experiencias concretas y en la aplicación de leyes y principios para la mejor organización y funcionamiento empresarial, pero sin la base epistemológica ni la aplicación de otros conocimientos que les permitan formarse como investigadores y estar preparados para elaborar y ejecutar proyectos de investigación y obtener resultados de trascendencia científica y social. Los planteamientos formulados servirán como punto de partida para que los profesionales mencionados consideren la epistemología como conocimiento esencial para dar mayor consistencia científica a las áreas que componen la estructura de la ciencia contable y su incidencia en el desarrollo empresarial.

  7. Fundamentos epistemológicos sobre la formación y desarrollo de la competencia investigación experimental / Training and developing research experimental competence framework

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    Álvarez, C.

    2016-01-01

    Full Text Available La formación basada en competencias es en la actualidad una imperiosa necesidad en la formación de profesionales, dadas sus contribuciones conceptuales y metodológicas. Es por ello que se pretende como objetivo analizar los fundamentos teóricos para la formación-desarrollo de la competencia investigación experimental en la Física (IEF, para estudiantes de carreras de ingeniería. En la investigación se aplican los métodos de nivel teórico y empírico para revelar las relaciones esenciales del objeto de investigación, a partir de los métodos lógicos del pensamiento inducción-deducción, en el examen de los hechos los investigadores siguieron tanto una progresión de los hechos singulares a propósitos generales, como de los hechos generales a los singulares y particulares. Competence-based training is now an urgent need in educating professionals for its ir conceptual and methodological contributions. This paper is aimed at constructing a framework for training and developing research experimental competence in engineer students studying physics. The research was carried out by means of theoretical and empirical methods in order to reveal the essential relationships of the object under study, logical procedures such as induction and deduction were also used following both a progression from form examining particular facts to the general and from the general to singular and particular facts.

  8. Os Fundamentos da Pedagogia Prussiana Liberal: reflexões sobre o hábito disciplinar no currículo militarista

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    Tomaz Martins Filho

    2018-04-01

    Full Text Available A pedagogia prussiana liberal no Brasil se dissemina por meio da ideia de disciplina e rigor. A educação prussiana tem sua prática embasada em fundamentos conceituais em uma filosofia disciplinar. O modelo prussiano defende a gratuidade e universalidade do ensino pautado na laicidade, e é influenciado pelas ideias iluministas. Este artigo tem como objetivo a compreensão da influência da educação prussiana liberal no currículo disciplinar dos colégios militares. Trata-se de uma pesquisa bibliográfica e documental em andamento no PPGE/UFT que visa, a partir do conceito de educação prussiana, presente no colégio militar do Tocantins. Discutimos a militarização dos currículos centrada na disciplina, como forma de desvelamento dos interesses atuais de pais e educadores. Percebe-se que o currículo prussiano busca pela produtividade mecânica. Quem tira as melhores notas e comporta-se bem é disciplinado, portanto, aprendeu. Caso aconteça o contrário, aplicam-se as sanções. Palavras-chave: Currículo disciplinar; História da Educação; Filosofia da Educação.   The Foundations of Prussian Liberal Pedagogy: reflections on the disciplinary habit in the militarist curriculum ABSTRACT The liberal Prussian pedagogy in Brazil spreads through the idea of discipline and rigor. Prussian education has its practice grounded in conceptual foundations in a disciplinary philosophy. The Prussian model defends the gratuitousness and universality of secular education, and it is influenced by Enlightenment ideas. This article aims at understanding the influence of liberal Prussian education on the disciplinary curriculum of military colleges. This is a bibliographical and documentary research in progress in the PPGE / UFT that aims, from the concept of Prussian education, present in the military college of Tocantins. We discuss the discipline-centered militarization of curricula as a way of unveiling the current interests of parents and

  9. RPL13A and EEF1A1 Are Suitable Reference Genes for qPCR during Adipocyte Differentiation of Vascular Stromal Cells from Patients with Different BMI and HOMA-IR.

    Science.gov (United States)

    Gentile, Adriana-Mariel; Lhamyani, Said; Coín-Aragüez, Leticia; Oliva-Olivera, Wilfredo; Zayed, Hatem; Vega-Rioja, Antonio; Monteseirin, Javier; Romero-Zerbo, Silvana-Yanina; Tinahones, Francisco-José; Bermúdez-Silva, Francisco-Javier; El Bekay, Rajaa

    2016-01-01

    Real-time or quantitative PCR (qPCR) is a useful technique that requires reliable reference genes for data normalization in gene expression analysis. Adipogenesis is among the biological processes suitable for this technique. The selection of adequate reference genes is essential for qPCR gene expression analysis of human Vascular Stromal Cells (hVSCs) during their differentiation into adipocytes. To the best of our knowledge, there are no studies validating reference genes for the analyses of visceral and subcutaneous adipose tissue hVSCs from subjects with different Body Mass Index (BMI) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. The present study was undertaken to analyze this question. We first analyzed the stability of expression of five potential reference genes: CYC, GAPDH, RPL13A, EEF1A1, and 18S ribosomal RNA, during in vitro adipogenic differentiation, in samples from these types of patients. The expression of RPL13A and EEF1A1 was not affected by differentiation, thus being these genes the most stable candidates, while CYC, GAPDH, and 18S were not suitable for this sort of analysis. This work highlights that RPL13A and EEF1A1 are good candidates as reference genes for qPCR analysis of hVSCs differentiation into adipocytes from subjects with different BMI and HOMA-IR.

  10. Los fundamentos de la libertad

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    Thomas Buchheim

    2013-11-01

    Full Text Available Three conditions for human freedom are to be distinguished: (1 The reality of the activity of living individuals, (2 the causal relevance of mental states and (3 an irreducibly subjective aspect in living things. These conditions provide a way of describing the relation between body and soul, such that the conditions are fulfilled: firstly, the reality of activity implicitly assumes the substantial identity of body and soul in every active individual that exists as a body. Secondly, there are however fundamental formal differences between the mental and physical states of such bodies, so that a duality of the states possessed by a living individual has to be recognised along with the substantial identity of its body and soul. Hence the causal relevance of mental states for the occurrence of certain actions may act as the peculiar mark of freedom. Finally, the distinction between the objectively recognised existence of states and the subjective possession of them is the reason that certain actions cannot be deduced from objective knowledge of reality, however complete the latter may be. This argument shows that actions cannot be seen as the logical consequence of preceding states of the world, even if the actions in question were causally completely determined. Such a view of actions is, however, the standard justification that freedom is incompatible with determinism.

  11. Fundamentos del derecho sancionador tributario

    OpenAIRE

    Sánchez Gervilla, Antonio,

    2017-01-01

    Es podria afirmar que el Dret sancionador administratiu, i per tant el Dret sancionador tributari, és una de les branques del Dret que més controvèrsia ha generat des de la seva gènesi; bona prova d'això la podem trobar en la seva evolució històrica, atenent al fet que aquest va evolucionar des del inicialment denominat Dret penal de policia, passant pel Dret penal administratiu, el Dret penal de l'ordre, fins arribar a l'actual Dret sancionador administratiu. En la nostra opin...

  12. Fundamentos conceptuales del resultado global

    Directory of Open Access Journals (Sweden)

    Francisco Sousa Fernandez

    2009-07-01

    Una vez delimitado su soporte conceptual, además de destacar la existencia de un gap significativo entre el mismo y la realidad de su regulación actual, queremos analizar la incidencia de su adopción en la práctica, para lo que revisamos las contribuciones empíricas de los últimos años.

  13. Fundamentos epistemológicos da teoria modular da mente de Jerry A. Fodor Epistemological fundaments of Jerry A. Fodor's modular theory of mind

    Directory of Open Access Journals (Sweden)

    Kleber Bez Birolo Candiotto

    2008-01-01

    Full Text Available Este artigo é uma apresentação dos fundamentos da teoria modular desenvolvida por Jerry A. Fodor e uma reflexão sobre seus principais desafios. A noção de modularidade da mente de Fodor, por um lado, procura superar as insuficiências metodológicas e epistemológicas do associacionismo e do localizacionismo a respeito das explicações da estrutura e do funcionamento mental; por outro lado, é uma oposição à postura culturalista de Vygotsky, para o qual as funções superiores da mente, como a cognição, são produtos artificiais, culturais. A psicologia cognitiva de Chomsky converteu esse produto "artificial" em "natural", postulando a existência de módulos inatos para desempenhar funções cognitivas específicos. Com base nessa ideia de Chomsky, Fodor procura explicar a mente como um conjunto de módulos. No entanto, sua principal contribuição para as ciências cognitivas é a apresentação da arquitetura mental em dois níveis e a afirmação da existência de módulos centrais responsáveis pelas atividades cognitivas superiores, como criatividade, reflexão ou imaginação.The aim of this paper is to present the basic elements regarding the modular theory developed by Jerry A. Fodor and some considerations about its main challenges. Fodor's notion of mind modularity, on the one hand, aims at overcoming the methodological and epistemological gaps of associationism and localizationism concerning the explanations of the structure and functioning of the mind; on the other hand, Fodor's notion stands as an opposition to Vygotsky's culturalist posture, since for the latter the higher functions of the mind, such as cognition, are artificial and cultural products. Chomsky's cognitive psychology has converted this "artificial" product into a "natural" one, postulating the existence of innate modules to perform specific cognitive functions. Based on Chomsky's idea, Fodor describes the mind as a group of modules. However, his main

  14. Integración de un curso MOOC y de un PLN-PLE en un curso presencial sobre fundamentos de la programación

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    Joel Ricardo Jiménez Cruz

    2017-01-01

    Full Text Available En este trabajo se describen las experiencias educativas en un curso sobre Fundamentos d e Programación e n computadoras para alumnos de Ciencias Sociales y Humanidades que integra clases presenciales con elementos de la educación virtual como la participación en un curso masivo y abierto en línea (MOOC y la elaboración de entornos y redes personales de aprend izaje (PLE - PLN. Esta hibridación de componentes presenciales y virtuales requiere de una integración y sincronización adecuada. En este sentido se ha tomado al curso MOOC como un “a yudante” en la impartición de l a parte práctica del curso presencial y en el salón de clases se revisa la parte teórica y se llevan a cabo ejercicios y comentarios que tratan de integrar a las dos modalidades educativas. Esta integración se ve reforzada por el PLN - PLE que cada uno de los estudiantes va desarrollando conforme al avance en clase y en el curso masivo. Los PLNs - PLEs en su conjunto se pueden considerar como ciber - espacios de intercambio de información y construcción del conocimiento. La coordinación central de las actividades de ambas modalidades educativas se realiza por medio de un entorno virtual de enseñanza aprendizaje (EVEA implementado en Moodle. El diseño instruccional que se ha seguido en clases está sustentado por la metodología del aprendizaje basado en proyectos que le permite al profesor y a los alumnos t ener una visión y un objetivo bien planteados desde el principio del ciclo escolar. El marco pedagógico que soporta a los elementos presenciales y virtuales se da dentro de un contexto de aprendizaje conectivista que pretende alcanzar diferentes niveles de interacción e involucramiento cognitivo entre los participantes.

  15. Cuidados Paliativos - Fundamentos e Abrangência: Revisão de Literatura/Palliative Care - Submissions and Comprehensiveness: Literature Review

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    José Vitor da Silva

    2013-09-01

    Full Text Available Os objetivos deste estudo foram identificar os fundamentos e a abrangência dos cuidados paliativos; compreender as suas abordagens atuais e conhecer as categorias profissionais que integram os cuidados paliativos e o luto referente aos familiares e equipe multiprofissional. O conteúdo expresso mostrou que os cuidados paliativos estão baseados em princípios próprios; a dimensão humana deve prevalecer entre as atitudes profissionais e suas abordagens se estendem ao paciente, familiares e profissional de saúde. Todos os profissionais de saúde podem integrar a equipe de cuidados paliativos; porém, há necessidade de preparo profissional sob a luz da interprofissionalidade. O cuidado paliativo deve se iniciar com a elucidação diagnóstica e permanecer até o período de luto pós-morte. Conclui-se que os cuidados paliativos constituem resposta indispensável aos problemas relacionados com o final da vida. A sua instituição e manutenção nos serviços de saúde são recursos de assistência quando a ciência e a tecnologia saíram de cena. This study aims to identify the submissions and comprehensiveness of palliative care; to comprehend its current approach and to get to know the professional categories that integrate palliative care and mourning referring to families and the multiprofessional team. The expressing content showed that palliative cares are based on own principles, the human dimension must prevail in the professional attitudes and its approach extends to the patient, families and healthcare professionals. All the healthcare professionals can take part of the team of palliative care, but it’s necessary professional training by the light of interdisciplinary approach. Palliative care must initiate by diagnostic elucidation and remain up to the mourning period after death. It’s concluded that palliative cares constitutes indispensable answers to the problems related to the ending of life. Its institution and maintenancein

  16. ANÁLISIS DE LA DISCLOSURE DE LOS REQUERIMIENTOS DE PAGOS PÚBLICOS: INFLUENCIA DE LA LEGISLACIÓN Y FUNDAMENTOS DE LA TEORÍA CONTABLE

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    Lucas Oliveira Gomes Ferreira

    2012-03-01

    Full Text Available La finalidad del estudio es analizar la disclosure de los requerimientos de pagos públicos a la luz de la Teoría Contable, además de verificar si la legislación vigente interfiere en el tratamiento contable de esos valores. Em ese sentido, fue realizada investigación bibliográfica y documental sobre el armazón legal y procedimentos contables adoptados y efectuada colecta de datos en el Sistema de Colecta de Datos de la Secretaría del Tesoro Nacional (SISTN, en el período de 2004 a 2009, además de estudio realizado por el Supremo Tribunal Federal (STF en 2004. La justificativa del estudio está en la percepción de que más de la mitad de los requerimentos de pago públicos no está registrada en las cuentas públicas. Como consecuencia, considerando que los requerimentos de pago configuran (1 derecho líquido y cierto al requirente en el proceso, y (2 deuda efectiva del ente público, la falta de disclosure perjudica tanto al beneficiado por la decisión judicial - que no ve reflejado su derecho en las cuentas públicas y tampoco tiene expectativa para cobrar -, en lo referente al gestor gubernamental y a la sociedad - que no disponen de informaciones confiables que permitan gerenciar esos valores de manera eficaz. La innovación consiste en la discusión sobre la identificación del adecuado momento del hecho generador de los requerimientos de pago públicos y de la propuesta de disclosure considerando la clasificación de riesgo. Concluye que la influencia de la legislación vigente y la no observancia de los fundamentos de la doctrina contable están entre los probables factores que han afectado la adecuada contabilización de los requerimentos de pago en el ámbito de la Administración Pública brasileña.

  17. Los fundamentos metafísicos de la ética y la política en Lawrence Dewan: Elementos para la construcción de una comunidad democrática, justa y pacífica

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    Liliana Beatriz Irizar

    2010-01-01

    Full Text Available Este trabajo tiene como objetivo presentar las bases fundamentales de la ética y de la política tal como aparecen de modo reiterado en la obra de Lawrence Dewan, quien siguiendo a Tomás de Aquino, afirma que la naturaleza humana está orientada naturalmente por el Creador hacia una meta final de plenitud natural ysobrenatural. De modo que, una sociedad que pretenda instaurar estilos de convivencia democrática justos y pacíficos debe necesariamente atender a estos fundamentos metafísicos y antropológicos.

  18. Colección de exámenes de la asignatura Aplicación de Ordenadores 2005 – 2011: fundamentos de programación y algoritmia

    OpenAIRE

    Quereda Gómez, Emmanuel David; Bañón Blázquez, Luis

    2011-01-01

    Esta divulgación docente recoge los ejercicios resueltos de aquellos exámenes realizados durante los curso 2005-2011, correspondientes a la asignatura Aplicación de Ordenadores de 3º curso de la titulación de Ingeniería Técnica de Obras Públicas de la Escuela Politécnica Superior de la Universidad de Alicante. El contenido de esta colección de exámenes versa sobre fundamentos de programación y algoritmos.

  19. Herdeiros de uma tradição:uma investigação dos fundamentos teológico- ideológicos do conservadorismo metodista na crise da década de sessenta

    OpenAIRE

    Daniel Augusto Schmidt; UMESP

    2011-01-01

    Este trabalho estuda uma crise vivida pela Igreja Metodista na segunda metade da década de sessenta. Influenciado pelo ambiente político da ditadura militar, o metodismo brasileiro foi campo de um embate entre as alas liberais e conservadoras da denominação. Palco deste conflito foi a Faculdade de Teologia e o II Concílio Geral Extraordinário, em 1968, além de uma série de eventos que a ele se seguiram durante os anos de 1969 e 1970. A pesquisa problematiza os fundamentos teológicos e ideológ...

  20. Plasma rico en plaquetas: fundamentos biológicos y aplicaciones en cirugía maxilofacial y estética facial Platelet-rich plasma: biology and applications in maxillofacial surgery and facial aesthetics

    OpenAIRE

    Jordi Rodríguez Flores; María Angustias Palomar Gallego; Jesús Torres García-Denche

    2012-01-01

    Esta revisión presenta el uso del preparado de plasma rico en plaquetas (PRP) como una herramienta potenciadora de ciertas características histológicas de los tejidos conformados por células con receptores para los factores de crecimiento plaquetarios. Se ha realizado una revisión sobre el plasma rico en plaquetas de la literatura publicada en PubMed. Se describen los fundamentos biológicos del PRP a nivel celular, la técnica de obtención, y sus usos clínicos en la actualidad.This review show...

  1. Fundamentos teóricos sobre las actividades físicas acuáticas y la salud y diseño de un programa de corrección postural de espalda en agua.

    OpenAIRE

    Rivas Flores, Daniel

    2013-01-01

    En este trabajo se tratan: los fundamentos teóricos sobre la actividad física acuática para la salud, así como los diferentes métodos para potenciar o trabajar cualidades físicas como pueden ser: la fuerza, resistencia o flexibilidad. El apartado que se desarrolla en más profundidad es el de la columna vertebral y el medio acuático. Para ello, se ha elaborado un programa semestral de reeducación postural en el agua, para cada una de las tres principales patologías del raquis: escoliosis, h...

  2. The Relationship of Fetuin-A, Adiponectin, Retinol Binding Protein-4 (RBP-4 and High Sensitivity C-Reactive Protein (hsCRP with Insulin Resistance (HOMA-IR in Obese Non Diabetic Men

    Directory of Open Access Journals (Sweden)

    Imelda Novianti

    2012-04-01

    Full Text Available BACKGROUND: Central obesity is the accumulation of visceral (intra-abdominal fat and is strongly known to be associated with insulin resistance and type 2 diabetes mellitus (T2DM. Obesity can cause adipocyte hypertrophy that results in dysregulation of adipokine expression. The abnormal function of adipocytes may play an important role in the development of a chronic low-grade proinflammatory state associated with obesity. Adiponectin, retinol binding protein (RBP-4 and fetuin-A play a role in the pathophysiology of insulin resistance. Expression of fetuin-A is increased due to fat accumulation in the liver. Elevated concentration of fetuin-A in the circulation can impair insulin signaling in muscle and liver as well as suppress adiponectin secretion, although its molecular mechanism is still unclear. The aim of this study was to identify the relationship of fetuin-A, adiponectin, RBP-4 and hsCRP with insulin resistance in obese non diabetic men. METHODS: This was an observational study with a cross-sectional design. The study subjects were 64 men with non diabetic abdominal obesity, characterized by waist circumference of 98.47±5.88 cm and fasting blood glucose of 85.75±8.36 mg/dL. RESULTS: This study showed that fetuin-A was positively correlated with HOMA-IR in obese non diabetic men with insulin resistance (r=0.128; p=0.570, although not significant. Fetuin-A was found to be correlated with adiponectin, RBP-4 and hsCRP (r=0.150; p=0.233; r=0.050; p=0.711; r=-0.04; p=0.445, although not significant. CONCLUSIONS: The concentration of fetuin-A showed a tendency to be positively correlated with HOMA-IR and with RBP-4 in obese non diabetic men, although statistically not significant. The concentration of fetuin-A showed a tendency to be negatively correlated with adiponectin and hsCRP although statistically not significant. There was no interrelationship between fetuin-A, adiponectin, RBP-4, hsCRP and HOMA-IR. Elevated concentrations of fetuin

  3. Implementation of the Thin Layer Agar Method for Diagnosis of Smear-Negative Pulmonary Tuberculosis in a Setting with a High Prevalence of Human Immunodeficiency Virus Infection in Homa Bay, Kenya▿ †

    Science.gov (United States)

    Martin, Anandi; Munga Waweru, Peter; Babu Okatch, Fred; Amondi Ouma, Naureen; Bonte, Laurence; Varaine, Francis; Portaels, Françoise

    2009-01-01

    The objective of this study was to evaluate the performance of a low-cost method, the thin layer agar (TLA) method, for the diagnosis of smear-negative patients. This prospective study was performed in Homa Bay District Hospital in Kenya. Out of 1,584 smear-negative sputum samples, 212 (13.5%) were positive by culture in Löwenstein-Jensen medium (LJ) and 220 (14%) were positive by the TLA method. The sensitivities of LJ and TLA were 71% and 74%, respectively. TLA could become an affordable method for the diagnosis of smear-negative tuberculosis in resource-limited settings, with results available within 2 weeks. PMID:19494065

  4. Propiedad sobre sí mismo, derechos liberales y autonomía: ¿el fundamento kantiano de Anarquía, Estado y utopía de Robert Nozick?

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    Felipe Schwember

    2016-01-01

    Full Text Available En Anarquía, Estado y utopía, Robert Nozick sostiene que los derechos naturales liberales se siguen de las restricciones morales indirectas a la acción y que éstas, a su vez, reflejan el principio kantiano subyacente de que los individuos son fines y no simplemente medios. En el presente trabajo se indaga en los supuestos fundamentos kantianos de la filosofía política de Nozick y en las relaciones que existen entre el concepto kantiano de dignidad y la propiedad sobre sí mismo, concepto este último que suele ser aceptado como el fundamento último de la teoría de la justicia de Nozick. Se concluirá que, pese a ciertas similitudes, el concepto de propiedad sobre sí mismo resulta incompatible con el concepto kantiano de dignidad. Se concluirá, asimismo, que el concepto de propiedad sobre sí mismo ofrece una clave de lectura consistente de la obra política de Nozick y que en consecuencia, para tales fines, debe ser preferido por sobre el concepto kantiano de dignidad.

  5. Avaliação da função das células beta pancreáticas através do modelo matemático de HOMA em portadoras de síndrome dos ovários policísticos: comparação entre obesas e não-obesas beta-cell function evaluation in patients with polycystic ovary syndrome using HOMA model: a comparison between obeses e nonobeses

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    Carolina Sales Vieira

    2007-03-01

    Full Text Available OBJETIVO: avaliar o efeito da obesidade sobre a função das célulasbeta pancreáticas de pacientes portadoras de síndrome dos ovários policísticos (SOP. MÉTODOS: estudo transversal no qual foram avaliadas 82 pacientes portadoras de SOP, selecionadas de forma consecutiva, no momento do diagnóstico de SOP. Pacientes com índice de massa corporal (IMC maior ou igual a 30 kg/m² foram consideradas SOP obesas (n=31. Valores de índice de massa corporal menores que este limite foram consideradas SOP não-obesas, o que correspondeu a 51 mulheres. Foram utilizadas a glicemia e a insulina de jejum para cálculo da função das células beta pancreáticas (HOMA-%beta-Cell e da resistência à insulina (HOMA-IR e QUICKI entre os grupos. Analisaram-se, também, variáveis secundárias como idade, idade da menarca, níveis séricos hormonais (testosterona, prolactina, LH e FSH e de colesterol total, triglicerídeos, HDL colesterol e LDL-colesterol. RESULTADOS: a idade da menarca das pacientes obesas com SOP (11,7±1,8 anos foi menor que as não-obesas (12,7±1,9 (pPURPOSE: to evaluate the effect of obesity on beta-cell function in patients with polycystic ovary syndrome (PCOS. METHODS: this cross-section study evaluated 82 patients with PCOS selected consecutively, at the moment of the diagnosis. We compared 31 PCOS obese women (BMI >30 kg/m² to 51 age-matched PCOS nonobese patients (BMI <30 kg/m². Using fasting glucose and insulin levels, homeostatic model assessment values for insulin resistance (HOMA-IR and QUICKI and percent beta-cell function (HOMA-%beta-cell were calculated. As secondary variables, the age at PCOS diagnosis, age of menarche, hormonal levels (testosterone, prolactin, FSH and LH, total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol were also analyzed. RESULTS: menarche was significantly earlier in obese PCOS patients (11.7±1.8 years than in nonobese patients (12.67±1.86 years (p<0.05. Obese patients presented

  6. Fundamentos sobre o conhecimento dos aditivos químicos presentes nas luvas de borracha Fundamentals of the knowledge about chemical additives present in rubber gloves

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    Hegles Rosa de Oliveira

    2011-10-01

    Full Text Available FUNDAMENTOS: Uma das causas mais frequentes de dermatite de contato alérgica, de origem ocupacional, são os aditivos da borracha, presentes nos Equipamentos de Proteção Individual. Os aditivos das luvas natural e sintética mais alergênicos são tiurams, mercaptos e carbamatos. OBJETIVO: levantar o nível de conhecimento em relação aos aditivos químicos utilizados na fabricação das luvas de borracha sintética. MÉTODOS: Foi aplicado um questionário aberto a profissionais que trabalham com fabricação, pesquisa, prescrição e comercialização das luvas. Foi adotado o método de pesquisa qualitativa. RESULTADOS: Foram entrevistadas 30 pessoas: 4 pesquisadores na área de Medicina do Trabalho, 5 médicos do Trabalho, 2 técnicos de segurança do Trabalho, 1 médico do sindicato de trabalhadores da borracha, 1 engenheiro de Segurança do Trabalho, 1 engenheira de Produção do setor de fabricação de luvas de borracha, 4 empresários importadores de luvas, 1 empresário fabricante de luvas, 3 empresários que comercializavam Equipamentos de Proteção Individual, 3 vendedores de lojas de Equipamentos de Proteção Individual, 2 empresários de lojas que comercializavam produtos para alérgicos e 3 dermatologistas. CONCLUSÃO: O conhecimento da composição química das luvas é pequeno. A rotulagem das luvas, com a descrição da composição química, facilitaria a escolha do melhor tipo de luva para cada pessoa. Esta ação, de baixo custo para as empresas, seria um ganho, do ponto de vista da saúde pública, e teria grande repercussão nos usuários de luvas de borracha.BACKGROUNDS: One of the most frequent causes of allergic contact dermatitis of occupational origin are rubber additives, which are present in Personal Protective Equipment (PPE. The most allergenic additives of natural and synthetic gloves are thiurams, carbamates and mercapto group. OBJECTIVE: To investigate the state of knowledge about the chemical additives

  7. Dignidad y autodeterminación física como fundamento del estatuto del paciente Dignidade e autodeterminação física como fundamento do estatuto do paciente Dignity and physical self determination as basis of patient status

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    Yolanda Gómez Sánchez

    2011-06-01

    Full Text Available Este trabajo contiene una reflexión sobre el estatuto del paciente. Tanto el Derecho de los Estados como el Derecho internacional y supranacional han respondido a los cambios operados en el ámbito de ciencias de la salud, incorporando normas específicas en relación con los derechos de las personas. Se analizan los conceptos de dignidad y libertad individual como fundamentos necesarios del estatuto del paciente y se defiende que la libertad de la persona se manifiesta en el ámbito biomédico a través de un nuevo derecho: el derecho de autodeterminación física, que define un ámbito de agere licere, un haz de facultades, de libertad decisoria, que debe estar protegida por el Derecho, y que permite a la persona decidir, optar o seleccionar qué hacer o no hacer respecto de aquellas cuestiones y situaciones que afecten su realidad física, su sustrato corporal. Complementariamente, se explica la posición transversal del principio de igualdad en la interpretación y aplicación de los derechos incluidos en el estatuto del paciente.Este trabalho contém uma reflexão sobre o estatuto do paciente. Tanto o Direito dos Estados como o Direito internacional e supranacional têm respondido aos câmbios operados no âmbito das ciências da saúde, incorporando normas específicas em relação aos direitos das pessoas. São analisados os conceitos de dignidade e liberdade individual como fundamentos necessários do estatuto do paciente e se defende que a liberdade da pessoa se manifesta no âmbito biomédico através de um novo direito: o direito de autodeterminação física, que define um âmbito de agir livre, um feixe de faculdades, de liberdade decisória, que deve estar protegida pelo Direito, e que permite à pessoa decidir, optar ou selecionar o que fazer ou não fazer a respeito daquelas questões e situações que afetam sua realidade física, seu substrato corporal. Complementariamente, se explica a posição transversal do princípio de

  8. La política educativa de la Unión Europea: fundamentos, evolución histórica y propuesta de un modelo para su análisis crítico

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    Javier M. Valle

    2004-01-01

    Full Text Available En este artículo se defiende la idea de que puede hablarse claramente de política educativa de la Unión Europea desde los mismos orígenes de esta entidad supranacional. El autor se detiene en presentar los fundamentos históricos que dan sentido a esa política, su evolución, organizada en una serie de etapas de las que nos presenta sus características y sus factores explicativos y, por último, ofrece un novedoso modelo de análisis que permitiría una interpretación crítica de esa política educativa. 

  9. Aproximación a los fundamentos contables, legales y morales del método de cargo y descargo o data por el que se rendían cuentas

    Directory of Open Access Journals (Sweden)

    Susana Villaluenga

    2013-12-01

    Tradicionalmente, este procedimiento ha sido estudiado desde el punto de vista contable, como prueban la gran cantidad de trabajos elaborados al respecto. La mayoría han venido analizando el papel del cargo y descargo o data en la contabilidad de diferentes organizaciones públicas y privadas a lo largo del tiempo. Sin embargo, en la forma de planificar la cuenta por cargo y descargo hemos observado aspectos que van más allá de lo puramente contable. En concreto, adivinamos una forma de proyectar la cuenta y razón en tres dimensiones: contable, jurídica y con un matiz religioso o moral, a cuyos fundamentos nos referiremos en este trabajo.

  10. Reflexiones en torno a una ficción: la premisa de la incapacidad como fundamento político-criminal de la inimputabilidad en el derecho penal de menores

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    Flavio D'Angelo

    2013-06-01

    Full Text Available Este artículo aborda la premisa de la incapacidad como fundamento político criminal de la inimputabilidad en el derecho penal de menores, al tiempo que explora los motivos que le confieren a ésta un carácter de ficción. Para lograr tal objetivo, se revisan los modelos de legislación de menores, así como el papel que juega el concepto de (incapacidad dentro de estas regulaciones, y se indaga la contradicción existente entre la capacidad y el discernimiento. Sobre la base de lo anterior, se propone una interpretación del dispositivo jurídico de incapacidad en clave ficcional (Bentham para, finalmente, presentar un aporte al debate que viene dándose en la República Argentina desde 1989 en relación con la reforma de la legislación de menores

  11. Los derechos humanos y la cultura de paz: fundamentos esenciales en la resolución del problema de la violencia domestica en Costa Rica. Su reflejo en prensa

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    Lic. Ligia Carvajal Mena

    2002-01-01

    Full Text Available Este artículo señala la importancia de los derechos humanos en el desarrollo de una cultura de paz .Presenta una visión de las luchas liberadas por las mujeres en pro de sus derechos y en la resolución del problema de la violencia doméstica en Costa Rica. A través de un estudio de prensa que data de julio de 1999 a 2000, se demuestra como éste constituye uno de los males que aumenta con rapidez en la sociedad costarricense y que menoscaba los derechos de las personas. La violencia doméstica se ha convertido en tema relevante en el marco de la sociedad costarricense. Los medios de comunicación colectiva transmiten a las audiencias diariamente noticias y reportajes acerca de este fenómeno social. Se podría decir que éste forma parte de la cotidianidad de la realidad costarricense y por ende ocupa un espacio en la agenda de los medios.Por lo anterior es preciso analizar dicha problemática a la luz de los Derechos Humanos y de la cultura de paz, pues ambos fundamentos son esenciales para comprender y buscar las soluciones posibles que contribuyan a disminuir esta situación. De ahí, que vale la pena preguntarse ¿Por qué es importante conocer y practicar los derechos humanos de las mujeres ?, así como tener conocimiento sobre los fundamentos sustanciales de una cultura de paz.

  12. Fundamentos filosóficos e teóricos para novas concepções do cuidar em enfermagem: contribuição da sociopoética Fundamentos filosóficos y teóricos para nuevas concepciones del cuidar en enfermería: contribución de la sociopoética Philosophical and theoretical basis for new conceptions of nursing care: contribution of the social poetic

    Directory of Open Access Journals (Sweden)

    Iraci dos Santos

    2010-08-01

    Full Text Available Este trabalho identifica a aplicação de princípios filosóficos e fundamentos teóricos da sociopoética em novas concepções do cuidar. Revisão sistemática de 30 trabalhos científicos. Categorias delimitadas: Dialogicidade no cuidar como instrumento tecnológico; Cuidar em enfermagem como tecnologia não invasiva. Nas novas concepções do cuidar, o cliente é o principal alvo do trabalho em enfermagem. Concluiu-se que os fundamentos da sociopoética foram aplicados revelando uma perspectiva onde a ética do cuidar, traduzida no respeito aos clientes e aos seus saberes para o autocuidado, conduz à autonomia e à solidariedade entre estes e os profissionais. A sociopoética, como método de pesquisa e prática social, revela aspectos orientadores de uma nova perspectiva a ser desenvolvida no cuidar em enfermagem.Este trabajo identifica la aplicación de los principios filosóficos y fundamentos teóricos de la sociopoética en nuevas concepciones del cuidar. Revisión sistemática de 30 trabajos científicos. Categorías delimitadas: Diálogo en el cuidar como instrumento tecnológico; Cuidar en enfermería como tecnología no invasiva. En las nuevas concepciones del cuidar, el cliente es la primera meta del trabajo en enfermería. Se concluyó que los fundamentos de la sociopoética fueron aplicados revelando una perspectiva donde la ética del cuidar, traducida en el respecto a los clientes y a sus conocimientos para el autocuidado, conducen a la autonomía, a la solidaridad entre estos y los profesionales. La sociopoética, como método de investigación y práctica social, revela aspectos orientadores de una nueva perspectiva a ser desarrollada en el cuidar en enfermería.This work identifies the application of the philosophical and theoretical basis of the social poetic in new conceptions of nursing care. Systematic review of 30 research works. Delimited categories: Dialogue in taking care of as technological instrument; To take

  13. インスリン抵抗性指標としてのへパリン投与前血清リポ蛋白リパーゼ量とHOMA2関連指数の比較

    OpenAIRE

    阿部, 美里; Abe, Eri

    2010-01-01

    インスリン抵抗性には, 高血圧, 糖尿病, 高脂血症など動脈硬化症の危険因子を高率に合併するため, 早期発見および治療後の評価のため簡便な指標が求められている. 一般にインスリン抵抗性の指標として広く用いられるHOMA指数は, 空腹時血糖上昇例ではインスリン抵抗性を反映しない, 肝臓以外の臓器のインスリン抵抗性を反映しない, インスリン測定法により値が異なる等の欠点が指摘されていたが, 近年Levy JC らにより, これらの欠点を改善したとされるHOMA2指数が導入され, その有用性が検討されている. 一方で, 近年ヘパリン投与前血清リポ蛋白リパーゼ量 (Pr-LPL) は, 簡便なインスリン抵抗性の指標となりうることが報告され注目されているが, HOMA2指数との間でその有用性を比較した報告は無い. 今回は糖尿病患者におけるインスリン抵抗性指標としてのPr-LPLとHOMA2関連指標を比較検討した. インスリン未使用の2型糖尿病患者118人を対象とし, 空腹時採血にてPr-LPL, HOMA-IR, HOMA2-IR, HOMA2-%S を測定した. Pr-LPLは第一化学の...

  14. The natural logarithm of zinc-α2-glycoprotein/HOMA-IR is a better predictor of insulin sensitivity than the product of triglycerides and glucose and the other lipid ratios.

    Science.gov (United States)

    Qu, Chunmei; Zhou, Xiaoxin; Yang, Gangyi; Li, Ling; Liu, Hua; Liang, Zerong

    2016-03-01

    The euglycemic-hyperinsulinemic clamp (EHC) is not available in most clinical settings and is costly, time consuming and invasive, and requires trained staff. Therefore, an accessible and inexpensive test to identify insulin resistance (IR) is needed. The aim of this study is to assess whether zinc-α2-glycoprotein (ZAG) index [Ln ZAG/homeostasis model assessment of IR (HOMA-IR)] is a better surrogate index for estimating IR or metabolic syndrome (MetS) compared with other surrogate indices. We performed a population-based cross-sectional study. Two hundred healthy subjects, 102 polycystic ovary syndrome (PCOS) patients, 97 newly diagnosed type 2 diabetes mellitus (nT2DM) and 84 impaired glucose tolerance (IGT) subjects were enrolled. The EHC was performed to identify IR. Circulating ZAG and adiponectin levels were determined by ELISA. The ZAG index was significantly lower in participants with IR including IGT, nT2DM and PCOS than in those without IR. In addition, subjects with MetS had lower ZAG indices and higher the product of fasting triglycerides and glucose (TyG) indices than those without MetS. The ZAG index showed a significantly stronger association with M values than the other surrogate indices, whereas the TyG index showed a stronger association with MetS. The optimal cutoff value of the ZAG index for detection of IR was 2.97 with a sensitivity of 88% and a specificity of 91%, whereas the optimal cutoff value of TyG index for detection of MetS was 4.90 with a sensitivity of 82% and a specificity of 86%. The ZAG index is a better marker than the other surrogate indices for identifying IR, whereas the TyG index has high sensitivity and specificity for identifying MetS. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Primer "Entrenamiento en Metodologías de Investigación Clínica en Chile" (EMIC-Chile: Fundamentos psicoeducativos First "Training in Clinical Research Methodologies in Chile" (EMIC-Chile: Psychoeducational foundations

    Directory of Open Access Journals (Sweden)

    B. Cabieses

    2010-12-01

    Full Text Available EMIC-Chile ("Entrenamiento en Metodologías para la Investigación Clínica en Chile" es un proyecto académico desarrollado durante el año 2008 en Chile para entrenar a profesionales de la salud y disciplinas afines en metodología de investigación clínica, con el objetivo de aumentar la calidad de los proyectos de investigación con fines concursables en nuestro país. El propósito de este artículo es dar a conocer el programa y sus fundamentos teóricos de enseñanza-aprendizaje, que estuvieron en la base de la estructura, metodología, evaluación y sistematización del conocimiento entregado. Para ello, primero se describe el programa, la metodología, la evaluación y el seguimiento. Posteriormente se detallan los aspectos psicoeducativos considerados, con especial énfasis en el aprendizaje social y la educación de adultos. Finalmente, se discute en torno a las posibles consideraciones de este programa para futuras intervenciones educativas en investigación en salud en Chile. Se espera que esta experiencia y sus fundamentos educativos sirvan de motor para futuras iniciativas en el área, a favor de la investigación en salud en Chile.EMIC-Chile ("Entrenamiento en Metodologías para la Investigación Clínica en Chile" is an academic project developed in Chile during 2008 to train health professionals in clinical research. The purpose of this initiative was to improve the quality of research projects that are submitted to apply for public funding. The aim of this article is to describe the psycho-educative theories that supported this training program, its structure, methods and evaluation. Firstly, the program is described in detail. Secondly, psycho-educative theories are described, with special emphasis of social learning theory and education for adults. Finally, implications of EMIC-Chile are stated, in order to improve future research training experiences in Chile. It is expected that this article enhance other research experts

  16. Unidade na diversidade: os fundamentos do Direito Cosmopolita e sua função no estabelecimento de uma moeda mundial Unity in diversity: the principles of Cosmopolitan Law and its role in the establishment of a world currency

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    Fernando dos Santos Lopes

    2011-12-01

    Full Text Available Este artigo objetiva verificar se é possível e como é possível utilizar o Direito Cosmopolita para reconstruir a atual ordem mundial segundo princípios de justiça, de modo a alcançar a paz perpétua e eliminar a pobreza. Serão expostos os fundamentos do direito cosmopolita, contrastando-os com as relações de poder vigentes no âmbito internacional que são caracterizadas como de interdependência assimétrica. Partindo-se da premissa de que as sociedades contemporâneas podem ser compreendidas como sistemas que oscilam entre a cooperação e o conflito, serão analisadas as estruturas institucionais subjacentes a essa tensão social, com destaque para o funcionamento do sistema monetário internacional. Após a identificação dos fatores institucionais causadores do conflito e da pobreza, analisaremos a proposta oferecida por keynes, em Bretton Woods, de criação de uma moeda mundial de reserva. Isso será feito com o intuito de constatar se essa proposta se adequa aos fundamentos do Direito Cosmopolita no sentido de ser um meio de eliminar a injustiça, retirando, por conseguinte, o principal óbice para o atingimento da paz.The objective of this work is to verify whether it is possible and how you can use the cosmopolitan law to rebuild the current world order according to principles of justice, a way to achieve everlasting peace and eliminate poverty. It will be exposed to the fundamentals of cosmopolitan law, contrasting them with the power relations prevailing in the international arena that are characterized as asymmetrical interdependence. Based on the premise that contemporary societies can be understood as systems that oscillate between cooperation and conflict, will be analyzing the institutional structures that underlie social tension, especially the functioning of the international monetary system. After identifying the institutional factors that cause conflict and poverty will be analyzed the proposal offered by keynes

  17. Os fundamentos da identidade européia na antiguidade, na idade média e nos tempos modernos = The bases of European identity in antiquity, middle ages and in modernity

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    Peter Johann Mainka

    2011-01-01

    Full Text Available Depois do fim da Segunda Guerra Mundial iniciou-se o processo da unificação européia, compreendendo todas as áreas do Estado e da sociedade (legislação, jurisdição, política, economia, instituições, etc. dos 27 Estados, tão diferentes quanto às tradições e à sua história, que compõem, no momento, a União Européia. Porém, quais são os fundamentos intelectuais e os valores culturais, quais são as idéias e memórias, que dão à Europa uma identidade coerente e compartilhada, em princípio, por toda a população européia de atualmente, quase 500 milhões de pessoas? Esses alicerces intelectuais da Europa remontam à Antiguidade, à Idade Média e aos Tempos Modernos. Este trabalho pretende apresentar alguns desses fundamentos comuns da Europa, postos na Idade Média e nos Tempos Modernos (por exemplo o Cristianismo, o Humanismo e o Iluminismo, e discutir a sua importância para a identidade européia.The process of European unification started immediately after the II World War. It comprised all the areas of State and society (legislation, jurisdiction, politics, economy, institutions and others in the twenty-seven countries, highly different in their traditions and history and which now make up the European Community. Which are the intellectual bases and the cultural values, which are the ideas and memories that give Europe a coherent identity shared, at least theoretically, by the European population of approximately 500 million people? Europe's intellectual bases go back to Antiquide, to the Middle Ages and to Modernity. Current essay will provide some of Europe's common principles posited in the Middle Ages and in Modernity (for instance, Christianity, Humanism and Illuminism and will discuss their importance within Euopean identity.

  18. A problemática atinente às limitações do mero reconhecimento legal dos direitos humanos: a dignidade humana, para além do individualismo liberal, enquanto discurso legitimador sobre os fundamentos morais

    Directory of Open Access Journals (Sweden)

    Suélen Farenzena

    2014-04-01

    Full Text Available O presente texto tem por objetivo analisar os limites do mero reconhecimento legal dos direitos humanos, demonstrando que a fundamentação desses constitui sua chave de proteção, efetivação e realização. O estudo propõe-se a demonstrar que o sistema positivo do direito, dissociado de valores morais, não é suficiente para proteção dos direitos humanos, evidenciando, em conseqüência, que para se efetivar a proteção desses direitos há de se encontrar um marco, um fundamento teórico-racional que a justifique, construído a partir da constatação de que os direitos humanos remetem a exigências imprescindíveis para a vida da pessoa humana, que, tento em vista a pretensão de universalidade, não pode restringir-se ao contexto ideológico do liberalismo.

  19. Análisis de los fundamentos jurídicos de la reforma a la legislación penal en materia de aborto en el Distrito Federal

    Directory of Open Access Journals (Sweden)

    Jean Cadet Odimba On'Etambalako Wetshokonda

    2010-01-01

    Full Text Available En 2007 se aprueba y publica la reforma al Código Penal del Distrito Federal en materia de aborto, con ella se validó la despenalización del delito de aborto, modificando el tipo penal y el mismo concepto de lo que es el aborto, convirtiéndose para el df en legal la práctica de la interrupción del embarazo dentro de las primeras doce semanas de gestación. Este trabajo es un análisis de los fundamentos jurídicos nacionales internacionales que protegen el derecho fundamental a la vida, así como las argumentaciones teóricas, filosóficas, biológicas, teológicas y jurídicas que se sostuvieron en los debates que conllevaron a la aprobación de la reforma a los artículos tanto del Código Penal de Distrito Federal y la Ley de Salud de Distrito Federal. El tema central de discusión y análisis es el derecho fundamental a la vida durante el periodo del embarazo.

  20. Fundamentos básicos de emissividade e sua correlação com os materiais refratários, conservação de energia e sustentabilidade

    Directory of Open Access Journals (Sweden)

    M. M. M. Novo

    2014-03-01

    Full Text Available Nas indústrias de base ou de transformação tais como, siderúrgicas, metalúrgicas, petroquímicas, entre outras, a energia consumida para o aquecimento da carga sofre perdas tanto pela exaustão dos gases quanto pelos refratários que revestem internamente esses equipamentos industriais que trabalham em altas temperaturas. De acordo a literatura, a tinta de alta emissividade, quando aplicada sobre a superfície interna do revestimento refratário desses equipamentos, contribui para o retorno do calor ao sistema, reduzindo perdas energéticas e minimizando custos no processo produtivo. Neste artigo são discutidos os fundamentos básicos da teoria de emissividade, como a radiação térmica e a teoria de bandas de energia, e a sua correlação com a composição química e aplicação de tintas refratárias visando minimizar custos decorrentes do consumo energético e tornando a unidade produtiva mais sustentável.

  1. Plasma rico en plaquetas: fundamentos biológicos y aplicaciones en cirugía maxilofacial y estética facial Platelet-rich plasma: biology and applications in maxillofacial surgery and facial aesthetics

    Directory of Open Access Journals (Sweden)

    Jordi Rodríguez Flores

    2012-03-01

    Full Text Available Esta revisión presenta el uso del preparado de plasma rico en plaquetas (PRP como una herramienta potenciadora de ciertas características histológicas de los tejidos conformados por células con receptores para los factores de crecimiento plaquetarios. Se ha realizado una revisión sobre el plasma rico en plaquetas de la literatura publicada en PubMed. Se describen los fundamentos biológicos del PRP a nivel celular, la técnica de obtención, y sus usos clínicos en la actualidad.This review shows platelet-rich-plasma (PRP as an enhancer of the histological characteristics of the tissues with platelet-derived growth factor receptors. A review has been made of the literature on the platelet-rich plasma published in PubMed. The article describes the cellular biology of PRP, the technique for obtaining it, and its clinical applications.

  2. O ensino de introdução à ciência da enfermagem e fundamentos de enfermagem em um currículo integrado: a experiência da escola de enfermagem Ana Néri da Universidade Federal do Rio de Janeiro (EEAN/UFRJ

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    Suely de Souza Baptista

    1985-06-01

    Full Text Available O trabalho constitui um estudo sobre o ensino da Introdução para Ciência da Enfermagem e Fundamentos de Enfermagem em um currículo integrado, desenvolvido de forma experimental pela EEAN/UFRJ. O enfoque principal deste programa de ensino é a reorganização das experiências curriculares visando favorecer o preparo do aluno face às novas características da prática profissional, preparando-o, deste modo, para uma atuação multidisciplinar e interdisciplinar. São evidenciadas as competências a serem alcançadas pelos alunos nas etapas do curso de graduação, sendo também apresentado em quadro demonstrativo do conteúdo da disciplina Fundamentos de Enfermagem e dos Planos Curriculares interdepartamentais.

  3. UM ESTUDO SOBRE A OBRA “FUNDAMENTOS DA POLÍTICA JURÍDICA” DE OSVALDO FERREIRA DE MELO, ATRAVÉS DOS ELEMENTOS DE PERCEPÇÃO JURÍDICA DA “TEORIA TRIDIMENSIONAL DO DIREITO” DE MIGUEL REALE

    OpenAIRE

    Lehmkuhl, Mílard Zhaf Alves

    2012-01-01

    O presente trabalho apresenta uma visão da obra “Fundamentos da Política Jurídica” de Osvaldo Ferreira de Melo a partir dos elementos de Percepção Jurídica, fato – valor – norma, colhidos da obra “Teoria Tridimensional do Direito” de Miguel Reale. O artigo se inicia com uma breve apresentação da obra “Fundamentos da Política Jurídica” e sobre os elementos de percepção jurídica da “Teoria Tridimensional do Direito”. Partindo dessa contextualização e dessa tridimensionalidade como ferramenta de...

  4. FUNDAMENTOS EPISTEMOLÓGICOS DA MATRIZ INSTITUCIONAL DOS NOVOS MODELOS DE EDUCAÇÃO SUPERIOR NO BRASIL: UMA ABORDAGEM QUALITATIVA DOS DOCUMENTOS INSTITUCIONAIS DA UNIVERSIDADE FEDERAL DO ABC

    Directory of Open Access Journals (Sweden)

    Manuel Tavares

    2017-12-01

    Full Text Available RESUMO: Nos países outrora chamados de terceiro mundo, hoje apelidados “países emergentes” e/ou “países periféricos e semiperiféricos”, surgem experiências inovadoras, de caráter contra-hegemónico, cujos projetos de educação superior se situam em uma perspectiva de equidade e justiça sociais incluindo os grupos sociais historicamente marginalizados e afastados do direito à educação superior. O texto que se apresenta pretende desvelar e reflectir sobre a estrutura institucional que sustenta um novo modelo de educação superior no Brasil, particularmente na Universidade Federal do ABC (UFABC. Os processos de democratização dos países, acompanhados de políticas direcionadas para o investimento em novas instituições de educação superior (IES, permitiram uma diversidade considerável no que diz respeito aos novos públicos estudantis. As universidades, tradicionalmente reservadas às elites, abriram-se a novos estudantes, de diferentes dimensões de gênero, etnia, classe social e gerações. Essa abertura criou desafios e expectativas quanto à democratização da educação superior, à inclusão da diversidade cultural e epistemológica, à promoção da interculturalidade e à descolonização das relações de poder e de conhecimento. Algumas políticas de experimentação institucional merecem referência particular. No Brasil, a acção dos governos pós-neoliberais de Lula e Dilma também se centrou na criação de universidades populares, apresentando perfis diferenciados e respondendo a objetivos específicos de ação política. A primeira delas foi a UFABC, cuja matriz institucional constitui objeto do nosso estudo. Centrar-nos-emos em uma pesquisa documental de caráter qualitativo utilizando a análise de discurso na perspectiva de N. Fairclough com o objetivo de inferir as linhas estruturantes do novo modelo de educação superior com foco específico nos fundamentos conceituais, no modelo pedagógico e

  5. A REINVENÇÃO DA VIDA MODERNA NA TRANSIÇÃO DO SÉCULO XIX PARA O SÉCULO XX: de uma cultura de fundamentos ao relativismo contemporâneo

    Directory of Open Access Journals (Sweden)

    Rogério Ferrer Koff

    2018-04-01

    Full Text Available O texto problematiza a noção moderna de humanidade, enquanto gênero universal, baseada em uma certa visão da natureza humana, em uma cultura de fundamentos e em uma profunda convicção na existência de uma essência universal do homem. A crise da noção de essência faz surgir a historicidade como a forma cabal do pensamento no século XIX, o que teria quebrado o caráter unívoco da palavra “ciência”. O pensamento do Século XX e do alvorecer do novo milênio nos parecem herdeiros desta crise. A relativização da ordem da verdade e a consequente ideia de um caráter provisório do conhecimento e da moral obteve abrigo no pensamento pós-moderno, caracterizado pela rejeição da tradição racionalista inaugurada no pensamento grego clássico e vigente até o Iluminismo. A experiência moderna e sua ênfase na universalidade do gênero humano passou a ser considerada positivista e etnocêntrica. No lugar de verdades absolutas, emergiram as categorias de heterogeneidade, diferença e relativismo.   PALAVRAS-CHAVE: Modernidade; Relativização; humanismo.     ABSTRACT The text problematizes the modern notion of humanity as a universal genre based on a certain vision of human nature, a culture of foundations and a deep conviction in the existence of a universal essence of man. The crisis of the notion of essence gives rise to historicity as the full form of thought in the nineteenth century, which would have broken the univocal character of the word "science." The thought of the twentieth century and the dawn of the new millennium seem to us inheritors of this crisis. The relativization of the order of truth and the consequent idea of ​​a provisional character of knowledge and morality gained shelter in postmodern thought, characterized by the rejection of the rationalist tradition inaugurated in classical Greek thought and in force up to the Enlightenment. Modern experience and its emphasis on the universality of the human race

  6. EL PODER DEL JUEZ PARA RECHAZAR IN LIMINE LA DEMANDA POR MANIFIESTA FALTA DE FUNDAMENTO THE POWERS OF THE JUDGES MAY REFUSE A COMPLAINT IN LIME WHEN IT IS UNFOUNDED

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    Iván Hunter Ampuero

    2009-01-01

    Full Text Available El presente trabajo tiene por objeto indagar acerca del contenido y alcance de la potestad contenida en el Art. 18 N°l del Proyecto de Código Procesal Civil, esto es, la posibilidad de que el juez rechace in limine una demanda cuando aparece manifiestamente infundada. El autor se hace cargo de dos problemas: en primer lugar, concretar el presupuesto que hace legítima la utilización del poder, esto es, precisar qué debe entenderse por una demanda que carece de fundamento, o que es lo mismo, cuándo una pretensión está manifiestamente infundada y; en segundo lugar, intentar resolver posibles cuestionamientos que puedan formularse a la legitimidad constitucional de la potestad, en especial, perfilar su compatibilidad (o falta de ella con el derecho a la tutela judicial efectiva y el debido proceso.This paper aims to investigate the content and scope of the legal authority contained in Article 18 Number 1 of the Civil Procedural Code project. This paper deals with the possibility that judges may refuse a complaint in limine when it is unfounded. The author addresses two issues: on the one hand, it defines the necessary elements that allow the use or invocation of this power, that is, to define what is necessary for a complaint to be considered unfounded; on the other hand, it addresses questions pertaining to the constitutional legitimacy of the power, specifically, its compatibility (or lack of with respect to the effective protection of the law and due process.

  7. As Instituições de Ensino Superior no Brasil: desafios e perspectivas para os gestores do século XXI - fundamentos em Pedro Demo e Pierre Bourdieu

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    Angela Maria Andrade Marinho de Souza

    2012-01-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2012v5n1p28   Este artigo trata dos desafios da Educação Superior Brasileira – fundamentos em  Demo  e Bourdieu  referentes em especial a Universidade do século XXI. Apresenta o funcionamento deste nível de ensino, de forma dialética, tendo em vista os gargalos que dificultam fazer pesquisa e educação no Brasil, especialmente, que tenham resultados positivos para a sociedade evidenciando o compromisso social a partir de suas reais finalidades. Parte-se de um aporte teórico bibliográfico, cuja análise objetiva chamar a atenção dos gestores acadêmicos e demais profissionais da Educação Superior, para a necessidade urgente de pensar a educação superior do século XXI, a função dos docentes e o perfil da Universidade, considerando os pressupostos do Paradigma Crítico. É importante discutir os rumos das Universidades Brasileiras e a formação dos novos profissionais. Investir em pesquisa e educação é investir em desenvolvimento. Daí o embate da comunidade científica em garantir a existência de um Conselho Deliberativo com a participação de todas as entidades científicas nacionais, para definir a destinação dos recursos e os rumos que a Universidade tomará neste terceiro milênio. A pesquisa  que evidencie compromisso social com o seu entorno para se institucionalizar de forma adequada, requer conexão com o ensino e com a extensão.

  8. FUNDAMENTOS CURRICULARES DE LA CIUDADANÍA EN UN ESTADO NEOLIBERAL: EL CASO DE SISTEMA EDUCATIVO COSTARRICENSE (CURRICULUM FUNDAMENTALS OF THE CITIZENSHIPS IN A NEOLIBERAL STATE:THE CASE OF THE COSTA RICAN EDUCATIONAL SYSTEM

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    Toruño Arguedas César

    2010-08-01

    Full Text Available Resumen:El presente ensayo, desarrollado como complemento a las actividades formativas de la Maestría en Planificación Curricular de la Universidad de Costa Rica, pretende reivindicar el papel del sistema educativo costarricense, enfocado en el área curricular, en la formación de un ciudadano como respuesta a intereses políticos económicos de corte neoliberal, ubicándolo como un producto histórico-social, no objetivo ni neutral. Para tal propósito, se analizaron los fundamentos curriculares económicos, socioculturales, filosóficos y pedagógicos del currículum costarricense, durante el Estado Neoliberal, en relación con la construcción de una ciudadanía neoliberal; obteniendo una caracterización general de la influencia, directa e indirecta, de un proyecto hegemónico cultural-económico y la formación ciudadana y sus implicaciones educativas.Abstract:The current essay, developed as a complement to the formative activities of the Masters in Curricular Planning of the University of Costa Rica, tries to vindicate the role of the Costa Rican educative system -focused on the curricular area- within the formation of a citizen as an answer to neoliberal political and economical interests, making him a subjective and not neutral social and historical product. In order to reach this goal, the economical, sociocultural, philosophical and pedagogical curricular principles of the Costa Rican curriculum design -during the neoliberal state- were analyzed, in relation to the formation of a neoliberal citizenship. This analysis was made, and a general characterization -of direct and indirect influence- of a cultural and economical hegemonic project was obtained, as well as the citizenship formation and its educative implications.

  9. Interpretação e compreensão: da hermenêutica metodológica à experiência hermenêutica como crítica e fundamento do saber filosófico

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    Marcos Alexandre Alves

    2012-04-01

    Full Text Available O presente artigo analisa a passagem da hermenêutica metodológica à experiência hermenêutica como crítica e fundamento do saber filosófico. Inicialmente, apresenta a crítica da hermenêutica à absolutizaçáo da lógica matemática como estrutura da pesquisa e produçáo de sentido na filosofia. A lógica matemática sedimenta a dinâmica da vida do homem por náo estar aberta às contingências da existência, porém a vida do homem náo se compreende sob a forma da lógica matemática. Posteriormente, demonstra que compreender a dinâmica da vida do sujeito pressupõe uma hermenêutica filosófica, que interprete o verdadeiro sentido do humano. Essa compreensáo hermenêutico-filosófica se estabelece mediante uma inter-relaçáo entre o sujeito e o algo a ser interpretado. Por fim, defende que a condiçáo de possibilidade dessa inter-relaçáo é a experiência hermenêutica, o que implica uma abertura ao que esse algo tem a dizer ao sujeito, tornando-se, assim, o ponto de partida da compreensáo e fundamentaçáo do saber crítico-reflexivo.

  10. Crítica aos fundamentos da psicologia em Politzer: psicanálise e psicologia concreta/Critical to fundamentals of psychology in Politzer: psychoanalysis and psychology concreta

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    José Luiz Pastre

    2006-01-01

    Full Text Available O artigo apresenta uma leitura do livro Crítica aos fundamentos da psicologia, de Georges Politzer. Nele, Politzer realizou sua leitura da obra A Interpretação dos Sonhos, de Freud, para construir as bases do que denominou psicologia concreta. O propósito é acompanhar o movimento que Politzer fez para demonstrar a sobrevivência da abstração na psicologia nascente, mas, também, acompanhando o movimento que ele fez para mostrar as potências dessa nova psicologia. Para acompanhar esse movimento, consideramos três conjuntos de questões, que aparecem no livro de Politzer como sendo importantes para que a nova psicologia possa constituir-se: a definição do fato psicológico; definição de um método; e, criação de noções próprias. This article presents a reading of Politzer’s book A Critique to the fundaments of Psychology, where the author, from reading Freud’s “Interpretation of Dreams”, tried to construct the bases for what he considered to be a concrete psychology. We undertook this reading trying to follow the movement Politzer makes towards demonstrating the survival of abstraction in the emergent psychology, but, also, following the movement that he makes towards showing the potencies of the new psychology. By accompanying this movement, we consider three sets of issues that appear in Politzer’s text as being important for the new psychology to become: a definition of the psychological fact; a definition of a method; and a creation of his own notions.

  11. Investigación: Fundamentos teóricos de la corriente de investigación sobre relevancia valorativa Principales contribuciones de la investigación sobre intangibles orientada hacia el mercado de capitales

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    Cecilia Rita Ficco

    2016-10-01

    Full Text Available El presente trabajo tiene por objetivo exponer y analizar los principalesfundamentos teóricos y conceptuales de la corriente de investigaciónsobre relevancia valorativa, contextualizándola dentro de la investigaciónorientada al mercado de capitales y del paradigma utilitarista, asícomo presentar algunos de los principales resultados que se han logradoa través de las investigaciones que, enmarcadas en dicha corriente, hanexaminado la relevancia valorativa de los intangibles. Metodológicamente,se ha realizado una investigación descriptiva y de tipo documental. Seconcluye que la corriente de investigación sobre relevancia valorativa, queencuentra en el modelo de Ohlson (1995 un sólido fundamento teórico,tiene dentro de sus líneas más prolíficas y con mayores perspectivas afuturo, a aquella tendiente a demostrar la relevancia valorativa de losintangibles en los mercados de capitales. Los resultados de las investigacionesrealizadas en esta línea han aportado evidencias claras acercade la importancia de los intangibles para la valoración de las empresas,los que resultan de sumo interés tanto para el ámbito académico comopara los organismos emisores de normas contables, ya que proporcionan una base sólida para decidir qué información debe ser incluida en losestados financieros con el fin de incrementar su utilidad, lo que resultafundamental para la mejora del modelo contable actual.

  12. Tecnologia como fundamento do cuidar em Neonatologia

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    José Antonio de Sá Neto

    2010-01-01

    Full Text Available Se trata de un artículo sobre la evolución histórica de la tecnología en neonatología, resaltando aspectos conceptuales y reflexivos sobre el impacto tecnológico en el proceso de cuidar. A pesar de que en los últimos años, la tecnología ha contribuido para mejorar la supervivencia de prematuros extremos nacidos con muy bajo peso, algunas veces da lugar a una modalidad de atención mecánica e impersonal, que se contrapone a cuestiones de índole ética y humana. Se propone una discusión crítica y reflexiva acerca del uso de la tecnología en el cuidado neonatal, destacando sus implicaciones y adecuaciones a las necesidades del recién nacido. Se concluyó que lo que determina si una tecnología es buena o mala, si deshumaniza, despersonaliza o interpreta como objeto al sujeto a cuidar, es la manera como es utilizada, convirtiéndose en imprescindible el perfeccionamiento y la actualización de los profesionales de la salud. En este ejercicio análitico es necesario reflexionar acerca de nuevas maneras de brindar cuidados, utilizando el arte, la sensibilidad y la creatividad en la adaptación y humanización de las tecnologías.

  13. Los fundamentos sociales del tercer sector

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    de la Torre, Isabel

    2003-08-01

    Full Text Available The theory of the gift, and the explanatory possibilities that its conceptual meaning offer and its methodological application, is the starting point to analyse the pro-social behaviours, present in the organizations that integrate the Third Sector: associations, foundations, benefit societies, co-operatives and labour societies. In all of these organizations, an interchange of goods and services is exercised, that can not be explained neither by the rules of the market nor by the principles of redistribution of the state. Altruism, solidarity and mutual principles, that inspire the pro-social behaviours, are usually practice through the networks of organized solidarity, that are based on the generalised trust and favour the civil society.

    La teoría del don, y las posibilidades explicativas que brindan su acepción conceptual y su aplicación metodológica, es el punto de partida para analizar los comportamientos prosociales, presentes en las entidades que integran el Tercer Sector: asociaciones, fundaciones, mutualidades, cooperativas y sociedades laborales. En todas estas entidades se ejercita un intercambio de bienes y servicios, que no pueden ser explicados ni por las reglas del mercado ni por los principios de redistribución del Estado. Los principios de altruismo, solidaridad y ayuda mutua, que inspiran los comportamientos prosociales, suelen practicarse a través de las redes de solidaridad organizada y favorecen el desarrollo de la sociedad civil.

  14. Fundamentos de deseño organizativo

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    García Chas, Romina

    2013-01-01

    Administración e Dirección de Empresas A realidade actual en cambio constante do contorno empresarial provoca que, cada vez máis, os empresarios precisen dispoñer dunha serie de capacidades e habilidades que lles permitan traballar nese contorno de incerteza e cambio. Na xestión de empresas non existen receitas máxicas pero a implantación dun determinado sistema de cara a toma das decisións ou de cara a resolución de conflitos pode incrementar as posibilidades de éxito. A materia Fundam...

  15. Fundamentos de la Administración

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    Gallardo-Gallardo, Eva

    2011-01-01

    El presente documento se ha elaborado con el fin de servir de material de apoyo para las clases del Tema 1 de la asignatura Administración de la Empresa del Grado de Administración y Dirección de Empresas, de la Universidad de Barcelona. No obstante, puede utilizarse como guía para todos aquellos profesores o estudiantes que estén interesados en estudiar el proceso administrativo y la evolución de la ciencia de la Administración. Este trabajo no pretende ser un estado de la cuestión exhau...

  16. FUNDAMENTOS DE LA ÉTICA

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    Héctor Gallo

    2013-06-01

    Full Text Available En este texto se hace un modesto análisis del estatuto de la ética en Kant y la función del deber y de la ley moral en la vida humana, tomando únicamente como referencia La fundamentación de la metafísica de las costumbres. Con este análisis se pretende mostrar los rendimientos de lectura de un texto con respecto al problema enunciado y se agrega como plus una puesta en tensión entre el deber kantiano y la ley freudiana que, por cierto, es algo que se transmite de uno a uno bajo la forma de castración y se asimila a pesar del sujeto. // This text presents a modest analysis of the status of ethics in Kant and the function of duty and moral law in human life, having as reference only the Groundwork of the Metaphysic of Morals. This analysis aims to show the yields of a reading con-cerning the problem stated. A tension between the Kantian duty and the Freudian law is a plus. The latter, indeed, is transmitted one by one under the form of castration and is assimilated despite the subject.

  17. Desarrollo sustentable: fundamentos, perspectivas y limitaciones

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    Badii, M. H.

    2004-07-01

    Full Text Available Se explican la filosofía, las nociones y los conceptos fundamentales del desarrollo sustentable, y enfatizan los desastres socioeconómicos, políticos e ecológicos que amenazan seriamente a la humanidad entera. Contrastan las diferencias abismales entre los países desarrollados y los país pobres y en vía de desarrollo. Se mencionan los intentos fallidos del ser humano conciente desde 1972 (la Declaración de Estocolmo al tratar de buscar salidas a los problemas ambientales y enfatizan los intereses de los conglomerados superpoderosos como obstáculos al progreso del desarrollo sustentable. Se mencionan los indicadores de sustentabilidad y también los índices con énfasis sobre la estimación de los factores de educación, salud, pobreza, medioambiente e ecología. Se define el concepto de la biodiversidad y los modelos matemáticos de uso actual para su estimación.

  18. Ergonomía. Vol. 1, Fundamentos

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    Rodríguez Mondelo, Pedro Manuel; Gregori Torada, Enrique; Barrau Bombardó, Pedro

    2001-01-01

    La obra ofrece una visión general de los aspectos básicos de la ergonomía. Está dividida en ocho capítulos, que abordan los temas de relaciones dimensionales, relaciones informáticas y de control, relaciones ambientales, gasto energético y capacidad de trabajo físico y trabajo mental. El libro pretende ser una guía básica para aquellas personas que se inicien en el apasionante campo de la ergonomía.

  19. Fundamentos de geometría euclidiana

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    Salazar Salazar, Luis Álvaro

    1984-01-01

    Este texto no pretende hacer un desfile monótono de definiciones, teoremas, demostraciones o corolarios sino que procurará hacer entender las definiciones, interpretar los enunciados de los principales teoremas y aplicarlos en la solución de algunos problemas. Tampoco se busca negar la importancia de las demostraciones de los teoremas y sus repercusiones en el desarrollo intelectual del lector, teniendo en cuenta que la geometrí­a es la matemática por excelencia, entendiéndose por esto que la...

  20. Fundamentos da migração

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    André Braz Golgher

    2004-01-01

    This is an introductory text that presents the migration process in many different aspects. Firstly, different methods commonly used in quantitative studies of migration are introduced, including the use of data bases, direct and indirect techniques. Secondly, different patterns of migration in the last centuries in Brazil and in the World are presented with particular attention to the most recent one. After this, three fundamental questions about migration are discussed. The first one deals ...

  1. Fundamentos de percepción visual

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    Fez Saiz, Dolores de; Viqueira Pérez, Valentín

    2014-01-01

    IMPORTANTE: CÓMO LEERLO. El libro se puede descargar desde el Repositorio de la Universidad de Alicante. Al tratarse de un libro con gran número de animaciones, gifs, vídeos y enlaces a internet, es conveniente abrirlo mediante un lector para epub3, aunque en cualquier otro lector la parte de texto es totalmente accesible. Está optimizado para el lector ibooks del iPad, se puede leer por ejemplo mediante el lector Gitden para Android, mediante los lectores Azardi y Adobe Digital Edition 4.5 p...

  2. La crisis Argentinia. Causas y fundamentos

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    Ana Silvia Vilker

    2004-01-01

    Argentina era reconocida en Europa por ser el país del trigo y de las vacas y también por el tango y el fútbol. Sin embargo en la actualidad es mencionada con regularidad en los medios de comunicación por estar en cesación de pagos -default- y en menor medida por la situación de pobreza e indigencia de una buena parte de su población. Para poner en perspectiva a la Argentina de hoy se realizará en el presente trabajo un breve recorrido sobre algunos aspectos de su desarrollo político-económic...

  3. Fundamentos del ácido fólico en la prevención primaria farmacológica de defectos congénitos Foundations of folic acid in the primary pharmacological prevention of congential defects

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    Roberto Lardoeyt Ferrer

    2005-04-01

    Full Text Available El ácido fólico fue descubierto en 1945 por los laboratorios Lederle, y desde entonces existe una gran variedad de derivados de esta vitamina, que se agrupan bajo el nombre común de folatos. Es en la APS donde se promueve la salud de la mujer y de su futura descendencia a través de la consulta de riesgo preconcepcional. Una de las acciones promotoras de la salud más importante de la asistencia preconcepcional, es la prevención de los defectos congénitos en la descendencia a través de la suplementación periconcepcional con folatos. El déficit de ácido fólico puede deberse tanto a factores genéticos como ambientales. Con el objetivo de incrementar los conocimientos de los profesionales de la salud que laboran en la atención médica a la mujer en edad reproductiva, se realizó una revisión del tema, en la que se tratan los fundamentos científicos que demuestran la importancia del uso de esta vitamina en la prevención de problemas congénitos como los defectos del tubo neural (DTN, síndrome de Down y de otras anomalías asociadas al déficit de este compuesto vitamínico.Folic acid was discovered in 1945 by Lederle laboratories and since then, there is a great variety of derivates of this vitamin that are grouped under the name of folates. It is in PHC where the health of woman and of her future off-spring is promoted through the office of preconceptional risk. One of the most important health promoting actions of preconceptional assistance is the prevention of the congenital defects in the off-spring by the periconceptional supplementation with folates. The deficit of folic acid may be caused by genetical and environmental factors. In order to increase the knowledge of the health professionals giving medical attention to women at gestational age, a review of this topic was made and the scientific foundations showing the importance of the use of this vitamin in the prevention of congenital defects, such as the neural tube defects

  4. O enfoque qualitativo na avaliação do consumo alimentar: fundamentos, aplicações e considerações operacionais The qualitative approach in the evaluation of food consumption: fundamentals, applications and operational considerations

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    Maria Lúcia Magalhães Bosi

    2011-12-01

    Full Text Available Disputas grosso modo infundadas entre defensores dos enfoques qualitativo e quantitativo têm impedido o reconhecimento dos benefícios das aplicações combinadas de ambos os métodos em um mesmo estudo, ou seja, de uma abordagem multidimensional e integrada. Não obstante, em anos recentes, o campo da Nutrição em Saúde Coletiva vem vivenciando um aumento na condução de estudos orientados não apenas pela mensuração, mas pela combinação de métodos qualitativos e quantitativos. Com efeito, o enfoque qualitativo tem muito a contribuir para a investigação do consumo alimentar, dentre vários outros objetos e temáticas, nas quais sobressai a importância do aprofundamento da compreensão da produção subjetiva, expressa em crenças, atitudes e comportamentos. Este artigo resume a natureza, os fundamentos e a utilidade do enfoque qualitativo em pesquisas no âmbito da alimentação e nutrição, esclarecendo como esses métodos têm sido ou podem ser usados para estudar os complexos problemas que se apresentam nesse campo, circunscrevendo a discussão ao âmbito dos estudos sobre consumo alimentar. A integração de ambos os métodos, qualitativo e quantitativo, mediante a complementaridade metodológica, pode minimizar os limites do emprego de cada enfoque de forma isolada.Unfounded disputes between advocates of qualitative and quantitative approaches have hindered the recognition of the benefits of combined application of both methods in the same study, ie, a multidimensional and integrated approach. Nevertheless, in recent years, the field of Nutrition in Public Health has experienced an increase in conducting studies guided not only by measurement, but by the combination of qualitative and quantitative methods. Indeed, the qualitative approach has much to contribute to research in food consumption, among many other objects and themes, in which stands the importance of deepening the understanding of subjective production, expressed

  5. Las TIC en el modelo semipresencial de la Universalización. Multimedia para\tel desarrollo del proceso de enseñanza aprendizaje de la asignatura Fundamentos Biológicos del Ejercicio Físico

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    Ideleichy Lombillo Rivero

    2009-12-01

    Full Text Available La multimedia que se presenta y que contiene los temas fundamentales a desarrollar en la asignatura Fundamentos Biológicos del Ejercicio Físico ha sido diseñada para que los profesores dispongan de un medio de enseñanza, del cual adolecen para la asignatura y los estudiantes de un material de apoyo para el autoestudio y el autoaprendizaje de los diferentes temas, que consta además, de bibliografías básicas y complementarias, guías para el estudio, y tareas que le permitirán vincular los conocimientos teóricos aprendidos, con la práctica, e interrelacionar los contenidos que aquí se presentan con el resto de las asignaturas que tributen al perfil del egresado. Cada uno de los aspectos tratados se corresponden con las temáticas planificadas para la impartición de la asignatura, en el 7mo semestre de la Carrera de Cultura Física en la SUM, y mediante el cual el discente tendrá la oportunidad de estudiar y ejercitar lo aprendido. Este material se ejecutará prioritariamente de forma individual y virtual a través de la herramienta Multimedia que se le ofrece, y de manera colectiva o grupal cuando lo requiera. En las temáticas que se trabajan se realizan recomendaciones para el trabajo con cada uno, atendiendo a las orientaciones que se ofrecen y por el orden en que aparecen y/o se imparten. La herramienta tiene diseñado un grupo de actividades que podrán ser realizadas durante los encuentros semipresenciales bajo las orientaciones del profesor permitiendo así la retroalimentación, la auto evaluación, respectivamente y la coevaluación, a razón de los debates y análisis que se puedan desarrollar en el grupo de las diversas materias que se enseñan, o de manera no presencial, e individual por cada estudiante que lo emplee en su autoaprendizaje.

  6. Aproximações sobre a transdisciplinaridade: algumas linhas históricas, fundamentos e princípios aplicados ao trabalho de equipe Approaching transdisciplinarity: some historical lines, foundations and applied principles to team work

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    Isac Nikos Iribarry

    2003-01-01

    Full Text Available O objetivo deste artigo é o de apresentar algumas aproximações conceituais e práticas sobre o tema da transdisciplinaridade. Em um primeiro momento, as aproximações realizadas serão alternadas pela exposição teórica dos temas relacionados à transdisciplinaridade e por algumas ilustrações práticas dos conceitos. O conceito de disciplina e suas derivações - multidisciplinaridade, pluridisciplinaridade, interdisciplinaridade e transdisciplinaridade - serão examinados em suas diferenças e conseqüências para o estabelecimento de relações entre diferentes disciplinas. Em seguida, serão apresentadas algumas origens históricas e alguns fundamentos da transdisciplinaridade. Na etapa final do trabalho, serão examinados os princípios práticos do trabalho de equipe em uma situação de transdisciplinaridade. Tais princípios estão organizados a partir do trabalho em equipe, da geração de novos dispositivos, da familiarização dos profissionais com cada área diferente da sua, da legibilidade e compartilhamento dos discursos e da tomada de decisão horizontal.This article aims at presenting some conceptual and practical approaches on transdisciplinarity. At first, all the made approaches will be presented in an alterned way with the theorical presentation of themes related to transdisciplinarity. Some practical illustrations of those concepts will be presented as well. The concept of disciplinarity and its derivations - multidisciplinarity, pluridisciplinarity and transdisciplinarity - are examined in their differences, as well as in their consequences for establishing a relationship between different areas. Following that, some historical origins and foundations of transdisciplinarity will be presented. In the last part of this paper, the practical principles of team work in a case of transdisciplinarity will be discussed. Those principles are organized from the work carried out by the team work, the generation of new devices

  7. Análisis de la Disclosure de los Requerimientos de Pagos Públicos: Influencia de la legislación y fundamentos de la teoría contable

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    Lucas Oliveira Gomes Ferreira

    2012-01-01

    Full Text Available La finalidad del estudio es analizar la disclosure de los requerimientos de pagos públicos a la luz de la Teoría Contable, además de verificar si la legislación vigente interfiere en el tratamiento contable de esos valores. En ese sentido, fue realizada investigación bibliográfica y documental sobre el armazón legal y procedimientos contables adoptados y efectuada colecta de datos en el Sistema de Colecta de Datos de la Secretaría del Tesoro Nacional (SISTN, en el período de 2004 a 2009, además de estudio realizado por el Supremo Tribunal Federal (STF en 2004. La justificativa del estudio está en la percepción de que más de la mitad de los requerimientos de pago públicos no está registrada en las cuentas públicas. Como consecuencia, considerando que los reque - rimientos de pago configuran (1 derecho líquido y cierto al requirente en el proceso, y (2 deuda efectiva del ente público, la falta de disclosure perjudica tanto al beneficiado por la decisión judicial - que no ve reflejado su derecho en las cuentas públicas y tampoco tiene expectativa para cobrar -, en lo referente al gestor guberna - mental y a la sociedad - que no disponen de informaciones confiables que permitan gerenciar esos valores de manera eficaz. La innovación consiste en la discusión sobre la identificación del adecuado momento del hecho generador de los requerimientos de pago públicos y de la propuesta de disclosure considerando la clasificación de riesgo. Concluye que la influencia de la legislación vigente y la no observancia de los fundamentos de la doctrina contable están entre los probables factores que han afectado la adecuada contabilización de los reque - rimientos de pago en el ámbito de la Administración Pública brasileña

  8. Pedagogical and Didactic Fundamentals of School Physical Education: Pillars of Unit or Debris of Fragmentation? Los Fundamentos Pedagógicos y Didácticos de Educación Física Escolar ¿pilares de una unidad o escombros de una fragmentación? Os Fundamentos Pedagógicos e Didáticos da Educação Física escolar: pilares de uma unidade ou escombros de uma fragmentação?

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    2008-03-01

    Full Text Available This research work was based on an interview about the relations of Pedagogy and Didactics conducted with Dr. Alfredo Furlán, an Argentinian pedagogue exiled in Mexico since 1974. This work discusses the idea that such subjects constitute, or should constitute, some form of fundamental to physical education as an educational subject. It suggests a horizontal debate among specialists and discourses that articulate theories and practices which are better placed, more local, less global and less abstract than what one tends to presume when theory and practice are discussed as totalizing categories. Without forgetting local concrete tasks that exist in the syllabus, this research work emphasizes that physical education at school has the importance of a finished project, being part of the set of contents that a school selects to be taught. It poses the issue of topic selection and its distribution as a main problem in the construction of a syllabus: discussing which contents (knowledge, skills, and attitudes need to be guaranteed before defining the competences that currently attract the attention of technocrats; establishing limits and landmarks for a subject to work under its own identity or the “organizing” divisions such technocrats are so fond of.

    Keywords*: Pedagogy – didactics – traditions – subjects – syllabus – contents – discourses.

    Con base en una entrevista sobre las relaciones entre la Pedagogía y Didáctica, realizada con el Dr. Alfredo Furlán, pedagogo argentino exiliado y radicado en México desde 1974, el presente trabajo discute la idea de que estas asignaturas constituyan o deban constituir algún tipo de fundamento para Educación Física como disciplina educativa. Propone, un debate horizontal entre especialistas y discursos que articulan teorías y prácticas mucho más situadas, más locales, menos universales y menos abstractas que lo que se tiende a suponer cuando se habla de la teoría y la

  9. Enseñanza de la evolución: fundamentos para el diseño de una propuesta didáctica basada en la modelización y la metacognición sobre los obstáculos epistemológicos

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    Gastón Mariano Pérez

    2018-01-01

    Full Text Available Numerosas investigaciones en didáctica de la biología muestran que el aprendizaje de la teoría de la evolución biológica es muy complejo. En el presente artículo exponemos los fundamentos teóricos de una propuesta didáctica basada en la modelización y en la metacognición sobre los obstáculos epistemológicos en relación con el aprendizaje de este contenido. Esta propuesta está orientada a que los1 estudiantes construyan un modelo de evolución por selección natural y de especiación alopátrica, a la vez que reflexionan sobre las estrategias de aprendizaje utilizadas en dicho proceso y sobre los obstáculos epistemológicos que dificultan este trabajo. Además de desarrollar los fundamentos de la propuesta didáctica, ofrecemos algunos ejemplos concretos de actividades.

  10. FUNDAMENTOS TEÓRICOS PARA A AVALIAÇÃO ESCOLAR FRENTE À INCLUSÃO DE ALUNOS COM DEFICIÊNCIA MENTAL: da prática autoritária para a prática inclusiva

    Directory of Open Access Journals (Sweden)

    Giovani Ferreira Bezerra

    2010-09-01

    Full Text Available O atual modelo de avaliação da aprendizagem escolar praticado na maioria das escolas regulares caracteriza-se por ser autoritário, disciplinador e  de  orientação  meramente  quantitativa. Entretanto, tal modelo revela-se insuficiente e  insustentável,  sobretudo  diante  da  inclusão  de alunos  com  deficiência  mental  nas  salas  de  aula  comuns,  pois  estes  estarão  sempre  em desvantagem em relação ao formalismo antipsicológico dos critérios tradicionais. Assim, surge a necessidade  urgente  de  se  articular  e  divulgar  novos  princípios  que  contemplem  uma  prática avaliativa  dinâmica,  qualitativa  e  inclusiva. É  exatamente  este  o  objetivo  do  presente  trabalho, que, para tanto, buscou na pesquisa bibliográfica os fundamentos teóricos. Pela pesquisa, pôde-se perceber  que  os  conceitos  de  Vygotsky sobre  Zona  de  Desenvolvimento  Proximal, Aproveitamento Escolar Absoluto  e Aproveitamento Escolar Relativo  são  os  que mais  podem orientar os professores, neste momento, quanto à correta verificação da aprendizagem escolar de todos os seus alunos, pois abrem espaço para uma perspectiva de avaliação totalizante, processual e  consciente  da  singularidade  cognitiva  e  psicológica  que  envolve  a  personalidade  de  cada educando. Estes conceitos lhes darão, assim, condições para refletir também sobre as conquistas de cada  criança,  e  não  apenas  para  condená-la  por  seus  eventuais  fracassos,  supostamente apontados por notas frias, cúmplices de uma rígida burocracia escolar e dissociadas de qualquer trabalho analítico cuidadoso. Palavras-chave: Avaliação  da  Aprendizagem  Escolar.  Inclusão de Crianças com  Deficiência Mental. Zona de desenvolvimento Proximal. Aproveitamento escolar absoluto. Aproveitamento escolar Relativo.

  11. HOMA: Israel's National Missile Defense Strategy (Abridged Version)

    National Research Council Canada - National Science Library

    Lailari, Guermantes

    2002-01-01

    ... (Hebrew for Fortress Wall), Chapter 1 discusses the fundamentals of missile defense and the reason why Israel's missile defense system affects US national security interests, Chapter 2 describes Israel's missile defense...

  12. Fundamentos económicos, fallos de mercado y exportación de capitales: América Latina y el mercado de Londres, 1880-1913 Economic Fundamentals, Market Failures and Capital Exports: Latin America and London's Capital Market, 1880-1913

    Directory of Open Access Journals (Sweden)

    Juan H Flores

    2012-12-01

    Full Text Available El presente trabajo analiza los mecanismos mediante los cuales la estructura del mercado de emisión de deuda soberana en Londres entre 1880 y 1913 afectaba los costos de los empréstitos de los gobiernos de países prestatarios. Si bien la reciente literatura ha debatido sobre la importancia de los fundamentos económicos en la percepción de riesgo país de los inversionistas, este trabajo enfatiza que su papel es secundario bajo ciertas circunstancias, y que la naturaleza de dicha percepción es dinámica. Mi demostración introduce el concepto de "relación bancaria" para describir la relación entre la banca internacional y los países prestatarios e ilustro su importancia para explicar la crisis Baring de 1890.This paper analyzes the mechanisms through which the structure of the market for sovereign debt in London affected borrowing costs in the period of 1880-1913. The traditional literature has emphasized the role of the economic fundamentals to explain the evolution of sovereign risk. More recent works, however, have demonstrated that economic fundamentals may be irrelevant under certain conditions, and that their effect on risk premia is dynamic in time. I use the concept of "relationship banking" to describe the relations between financial intermediaries, borrowing governments and borrowing costs, and provide a new explanation of the Baring crisis of 1890.

  13. Fundamentos teóricos para el cálculo de los parámetros técnicos de las líneas eléctricas aéreas de baja tensión para su uso en telecomunicaciones

    Directory of Open Access Journals (Sweden)

    Henry Arturo Bastidas Mora

    2009-05-01

    Full Text Available Este artículo presenta las propiedades de las redes de energía eléctrica para su utilización como canales para la transmisión de señales de telecomunicaciones. Comienza explorando los principios y fundamentos teóricos para el cálculo de los parámetros técnicos críticos de las líneas eléctricas, por lo que trata con detalle lo referente a los parámetros primarios: inductancia, capaci- tancia, conductancia y resistencia, y, asociados a estos, los parámetros secundarios (más útiles desde el punto de vista de las te- lecomunicaciones: impedancia característica y constante de propagación; de esta última, su componente real, la constante de atenuación. Se verifican las diversas topologías y la estructura de los sistemas eléctricos de potencia para líneas de media y baja tensión aéreas y se propone un modelo matemático para analizar su comportamiento a altas frecuencias extensible a la mayoría de los sistemas de distribución aéreos de energía eléctrica colombianos. El trabajo incluye una parte de los resultados de la in- vestigación denominada “Diseño de una solución a través de la tecnología PLT (Power Line Telecommunications para acceso a Internet de banda ancha en regiones rurales de Colombia”, realizada por el autor con la Universidad Piloto de Colombia. Me- diante la utilización del modelo matemático propuesto se tiene una herramienta teórica de una parte de los cálculos aplicables a PLT.

  14. Microeconomia e Meio Ambiente: Análise de Fundamentos Microeconômicos Inerentes à Gestão Ambiental nas Organizações MICROECONOMICS AND THE ENVIRONMENT: ANALYSIS OF MICROECONOMIC BASIS INHERENT TO THE ENVIRONMENTAL MANAGEMENT IN THE ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Nilton dos Santos Portugal

    2010-12-01

    of the microeconomic theory in the aspects of the enterprise environmental management is verified thus, mainly for the fact that the environmental question currently influences directly the strategic planning of the organizations.A pesquisa que se segue objetiva apresentar certos fundamentos da microeconomia passíveis de aplicação e análise na gestão ambiental das empresas. Inicialmente realiza-se uma revisão sobre os conceitos e fundamentos microeconômicos, como a curva de possibilidade de produção, custos de poluição e de controle, benefícios e custos totais e marginais e teoria dos jogos; sendo, posteriormente, abordadas suas possíveis influências, inclusive com exercícios hipotéticos para compreensão da aplicabilidade dos fundamentos. Importante salientar que, na abordagem da teoria dos jogos, demonstra-se a justificativa da ação das agências reguladoras como órgãos de implementação de controles ambientais nas empresas. As ferramentas aqui abordadas são consideradas sob o aspecto teórico, mas permitem uma posterior aplicação nos processos gerenciais, na busca por tecnologias produtivas verdes e por certificações específicas. A pesquisa utiliza como metodologia o método dedutivo, buscando da teoria geral da microeconomia uma aplicação específica na gestão ambiental e, como procedimento técnico, utiliza a pesquisa bibliográfica. Verifica-se, assim, a consolidação da aplicabilidade da teoria microeconômica nos aspectos da gestão ambiental empresarial, principalmente pelo fato de que a questão ambiental atualmente influencia diretamente o planejamento estratégico das organizações.

  15. Scientific aspects of climate change; Fundamentos cientificos del calentamiento global

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, G.

    2007-07-01

    For the last 35 years, the average temperature of the planet has been steadily increasing- Are the greenhouse gases emitted by human beings the cause? What will the consequences be? What can we do? The fourth report of the intergovernmental Panel on Climate change tries to answer these questions. There are clear signs of thawing that primary affect Greenland and the Antarctic, but there are still many doubts what the consequences will be throughout the century. In any case, it seems obvious that, if greenhouse gas emissions are not substantially reduced very soon, the rising temperature trend and its associated consequences will persist beyond the 21st century. (Author)

  16. Estruturas e fundamentos sociais: a leitura honnethiana de Habermas

    Directory of Open Access Journals (Sweden)

    Hélio Alexandre da Silva

    2013-08-01

    Full Text Available O presente artigo pretende sublinhar, na forma de breves apontamentos gerais, os contornos mais amplos da crítica de Honneth a alguns aspectos do pensamento habermasiano. Tal crítica é norteada especialmente por uma investigação dos critérios morais e normativos das lutas sociais que Honneth recupera, por meio de uma apropriação crítica do pensamento do jovem Hegel. O ponto central defendido por Honneth é que as possibilidades da experiência interativo-comunicativa não podem ser resumidas ou tomadas exclusivamente na interação linguística, nem mesmo esta última pode ser perseguida em seu aspecto ideal, sem a pressuposição dos contextos conflituosos nos quais ela sempre está inserida.

  17. SOBRE OS FUNDAMENTOS DA ARQUITETURA DA INFORMAÇÃO

    Directory of Open Access Journals (Sweden)

    Alfram Roberto Rodrigues de Albuquerque

    2011-10-01

    Full Text Available Expõe-se o estado atual da disciplina Arquitetura da Informação quanto a problemática terminológica da definição do campo de estudo, apresentando-se argumentos para uma definição de Arquitetura da Informação de uma forma ampla na qual os usos correntes dessa expressão sejam vistos como especializações. Defende-se uma definição com a utilização de um conjunto de propriedades mínimas cujas interações levam a uma terminologia formal e cuja abstração leva a uma definição formal do conceito que emprega a linguagem de morfismos da Teoria das Categorias. Trata-se de um recorte de alguns dos resultados obtidos na tese de doutoramento de um dos autores, defendida em setembro de 2010. O contexto da pesquisa é exposto e alguns dos resultados obtidos são delineados.

  18. FUNDAMENTOS DA TERMOGRAFIA PARA O ACOMPANHAMENTO DO TREINAMENTO DESPORTIVO

    Directory of Open Access Journals (Sweden)

    Eduardo Borba Neves

    2014-08-01

    Full Text Available Thermography is recognized diagnostic method since 1987 by the American Medical Association. This method involves the detection of infrared radiation emitted by the skin and provides the analysis of physiological functions related to the control of the temperature of the skin noninvasively, without exposing the patient to any type of radiation. The objective of this paper is to describe the background related to the use of thermal imaging (acquisition, analysis of thermograms and already known applications for monitoring sports training. To this end, the text is structured in the following topics: fundamentals of physiological temperature control, technical requirements of the equipment acquisition, analysis of thermal images, the acquisition protocol of thermal images, and monitoring of sports training by thermography. It can be concluded that thermography has been used increasingly in medical and sports area and already has applications for the diagnosis of musculoskeletal disorders in the evaluation of muscle recovery after training and competitions for athletes to release specific workouts and how predictor of VO2max. However, there are fundamental aspects of physiology of heat that must be understood in greater detail as the influence of the fat layer in the skin temperature and the thermal response of the body to different types of activity.

  19. Fundamentos kantianos dos axiomas do movimento de Newton

    OpenAIRE

    Vieira Coutinho Abreu Gomes, Írio

    2006-01-01

    Esse trabalho se insere na perspectiva fundacionista kantiana, particularmente no que diz respeito às três leis de Newton. Em sua obra de 1786, Princípios Metafísicos da Ciência da Natureza, Kant empreende a tarefa de fundamentar a física mecânica através de princípios metafísicos. Nosso objetivo nessa dissertação foi abordar essa obra especificamente em seu terceiro capítulo onde Kant trata dos axiomas do movimento de Newton. Nessa dissertação elucidamos a argumentação kantiana na fundamenta...

  20. Indigenismo: Fundamento Sociológico de la Nacionalidad.

    Directory of Open Access Journals (Sweden)

    Hernando Forero Caballero

    1999-04-01

    Full Text Available

    El hombre, por tendencia innata a través de los tiempos, se ha caracterizado por su impetuoso deseo de descubrir lo incógnito y el más allá, por su ambición de poder y riqueza, por su libertad personal y de la comunidad, por la conquista y el comercio para satisfacer su orgullo y para su sobre-vivencia.

    Los primeros medios de traslado humano fueron valiéndose de sus propios medios y de la navegación.

    Los fenómenos de la naturaleza, el deshielo, los vientos, las corrientes marítimas favorecieron el desplazamiento del hombre por los mares.

    Fue así, lo más probable, como se pobló el mundo.

    Podemos afirmar que el factor genético se transmite a través de las generaciones, con algunas variantes dadas por la mezcla de genes afines o contrapuestos, las circunstancias de acoplamiento racial y las condiciones del medio ambiente en que evoluciona una comunidad.

    Población inicial de la Nueva Granada

    Los indígenas que habitaron la Nueva Granada como núcleo básico de la formación de la nacionalidad colombiana tuvieron origen marcadamente heterogéneo.

    Los primeros pobladores de la Nueva Granada provenían:

    a De los imperios asiáticos costaneros del Pacífico: Chinos, Turcos y Mongoles, etc. que llegaron de la Beringia y navegando por la costa norte del Pacífico, penetraron al continente por tierra y por los ríos afluentes del Pacífico.

    B De las naciones vecinas del Mediterráneo, cuyos emigrantes arribaron por el Atlántico y ascendieron a los Andes por los ríos Magdalena, Orinoco, Meta y sus afluentes.

    Las migraciones sucesivas que llegaron al territorio de Nueva Granada buscaron el medio geográfico más apto para su sobrevivencia, las altas planicies y hondonadas de los ríos. La región Cundi-boyacense y Santandereana por los muiscas; Nariño y Cauca por los cofanes, paeces, guambianos, etc. San Agustín y Tierradentro por los andaquíes y la Sierra nevada de Santa Marta por los arhuacos y koguis.

    Otras inmigraciones se quedaron en las costas como los tumacos, los embera, los cunas, los caribes y los guajiros, etc.

    En fin, otros se establecieron en los valles y las riberas de los ríos, como los Desana, los Tunebos, etc.

    Durante siglos se acoplaron al ambiente natural y establecieron asentamientos, caseríos o pueblos y desarrollaron su propia cultura, basada en sus tradiciones, la influencia de la naturaleza de su entorno y la comunicación humana espontánea o por invasión de otras etnias.

    La demostración de que eran originarios de diversos pueblos y que inmigraron en diferentes épocas está en sus asentamientos separados, con cierto aislamiento familiar y tribal y una gran variedad de modalidades lingüísticas y costumbres...

  1. Fundamentos neuropsicológicos de la dislexia evolutiva

    Directory of Open Access Journals (Sweden)

    Jorge Alfredo Herrera Pino

    2007-01-01

    Full Text Available El siguiente artículo enmarca los principios de la neuropsicología de la dislexia evolutiva y realiza un recorrido desde su evolución histórica, en cuanto a su definición, hasta sus síntomas más característicos en los sujetos que la padecen. La dislexia se conoce como una alteración de la capacidad para aprender a leer que afecta un buen porcentaje de la población escolarizada. La dificultad se debe principalmente a una deficiencia en el desarrollo del lenguaje que se ve manifestado en sus síntomas iniciales en un retraso significativo del desarrollo de la conciencia fonológica que viene a ser un buen predictor de dicha alteración Mediante la revisión realizada para este artículo se da explicación al trastorno disléxico desde la neuropsicología, la que se ha encargado de exponer las características desde la relación cerebro-conducta y, además de la localización cerebral de la alteración, las perturbaciones visuales y auditivas y de las otras variables intervinientes en la aparición del trastorno como la genética y, más propiamente, la herencia. Por último, a manera de conclusión, se espera que con este artículo se abran nuevas líneas de investigación para el estudio del tema y contribuya al planteamiento de nuevas hipótesis sobre la neuropsicología de la dislexia.

  2. Fundamentos de computación con ADN

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Ortíz Triviño

    1998-05-01

    Full Text Available Este artículo presenta algunas ideas básicas para resolver problemas computacionales complejos, mediante el empleo de la estructura biológica del ADN y técnicas especializadas de laboratorio. Las características del ADN que se describen hacen posible codificar estructuras matemáticas, como las máquinas de Turing o las redes neuronales; para ello, la clave está en la interpretación del ADN como un generador de lenguajes.

  3. Considerações sobre o fundamento moral da propriedade

    Directory of Open Access Journals (Sweden)

    Luiz Felipe Netto de Andrade e Silva Sahd

    2007-01-01

    Full Text Available Para Hugo Grotius a propriedade era originalmente coletiva, e os homens tinham, de comum acordo, decidido dividi-la, o que havia feito nascer a propriedade privada. Como a propriedade privada devia ser garantida pelo governo, ela só podia ser uma emanação deste. O problema dessa análise, para John Locke, era que ela era perfeitamente compatível com o absolutismo, pois um monarca podia garantir essa propriedade. Como Locke funda a propriedade sobre a lei natural, sua teoria da prioridade refuta, ao mesmo tempo, as teorias de Sir Robert Filmer e de Grotius e Samuel Pufendorf. A teoria da propriedade de Locke garante, por fim, a liberdade dos indivíduos.According to Hugo Grotius, property was originally collective, and men had commonly agreed to divide it. Consequence: private property. And private property should be guaranteed by the government, therefore, it had to emanate from it. To John Locke, the problem of such an analysis is that it is perfectly compatible with Absolutism, since the king could guarantee, in these terms, property as well. John Locke founds property on natural law, and doing so, refutes simultaneously Samuel Pufendorf's, Hugo Grotius' and Robert Filmer's theories about the same subject. John Locke's theory of property guarantees individual freedom.

  4. El humanismo cosmopolita como fundamento de la democracia universal

    OpenAIRE

    Llano Alonso, Fernando Higinio

    2012-01-01

    Los importantes cambios y acontecimientos que ha experimentado la sociedad internacional a lo largo de la primera década del siglo XXI, han permitido reabrir el debate en torno a la oportunidad de crear instituciones transnacionales y de constituir un sistema de Derecho cosmopolita que siente las bases de un futuro gobierno democrático mundial. En el presente trabajo se defiende el proyecto humanista cosmopolita de raíz kantiana, que en los últimos tiempos ha sido reivindicado por autores com...

  5. O fundamento estrutural do pensamento de Umberto Eco

    Directory of Open Access Journals (Sweden)

    Winfried Nöth

    2016-08-01

    Full Text Available Uma análise detalhada apresenta o método argumentativo a contrario, característico do artigo "Existe a contracultura?", de Umberto Eco, como paradigmático do princípio estruturalista da constituição do sentido por meio de oposições semânticas. O artigo argumenta que muitos dos escritos de Eco podem ser lidos como aplicações do princípio estruturalista de que apenas diferenças ou oposições carregam significação. A evidência do modo como o pensamento de Eco está sob o encanto do princípio das oposições e da dialética da presença e da ausência é apresentada através do levantamento dos escritos gerais de Eco e também da inspeção das obras A estrutura ausente e Semiótica e filosofia da linguagem. Além disso, o artigo revela que o pensamento de Eco é igualmente atraído tanto por processos nos quais oposições anulam ou dissolvem a si próprias quanto pela crítica pós-estruturalista do pensamento estruturalista.

  6. Fundamentos de gestión de bibliotecas universitarias

    OpenAIRE

    Merlo Vega, José Antonio

    1998-01-01

    La biblioteca universitaria necesita una óptima gestión para desarrollar de manera conveniente sus servicios. Se estudian los principales elementos que intervienen en la gestión de las bibliotecas universitarias : los recursos humanos y los recursos económicos. Previamente se analizan las características y funciones de este tipo de bibliotecas y las estructuras administrativas en las que suelen organizarse las bibliotecas universitarias. Se tratan también otros aspectos, como la planificación...

  7. Fundamentos del Tipo de Cambio Real en Chile

    OpenAIRE

    Rodrigo Cerda; Alvaro Donoso; Aldo Lema

    2003-01-01

    Un modelo basado en la relación gasto-producto (efecto Salter-Swan) y los términos de intercambio, habría predicho un incremento más pronunciado del tipo de cambio real (TCR) en Chile durante la segunda mitad de los '80, una caída menos acentuada entre 1990 y 1997, y un aumento más fuerte a partir de 1998 cuando irrumpió la crisis financiera internacional. Este trabajo incorpora en forma exhaustiva otros factores en la determinación de largo plazo del TCR, tanto de oferta como de demanda. Usa...

  8. Indagações Sobre os Fundamentos da Linguagem

    Directory of Open Access Journals (Sweden)

    Ignacio Assis Silva

    1990-10-01

    Full Text Available l. O Dicionário de Semiótica I, de Greimas e Courtés, acostumou-nos a pensar na figurativização como um problema de semi ótica discursiva. Partindo de uma formulação genérica do conceito como as mil maneiras de contar como um sujeito disjunto de seu objeto-valor passa a conjunto ou vice-versa, os Autores acrescentam que a figurativização:- transforma processos em ações,- confere contornos figurativos ao sujeito que, com isso, se toma um ator (sofre ancoragem espacio-temporal.

  9. A representatividade nos conselhos gestores: fundamentos e elementos constitutivos

    Directory of Open Access Journals (Sweden)

    Carla Buhrer Salles Rosa

    2012-05-01

    Full Text Available O presente artigo tem como objetivo apresentar uma sistematização sobre um dos elementos que compõem e desafiam a materialização de processos democráticos de gestão social no Brasil contemporâneo: a representatividade dos segmentos sociais no interior de espaços institucionalizados de participação social (conselhos gestores de políticas públicas. Considerados como novas instâncias de intermediação pública, provocam alterações no âmbito do governo representativo, a partir da participação direta de segmentos da sociedade civil nesses espaços. Mesclando mecanismos de democracia direta e democracia representativa, reordenam a lógica do poder tradicional. A implantação dos conselhos gestores de políticas públicas no Brasil coloca no cenário político cem mil conselheiros que podem ser vistos como sujeitos políticos com possibilidades de contribuir com processos democráticos mais amplos, porém há que se preencher as lacunas existentes em tais espaços. Uma dessas lacunas é a efetiva representatividade.

  10. O Ensino de Empreendedorismo com Fundamento na Teoria Effectuation

    Directory of Open Access Journals (Sweden)

    Marcus Alexandre Yshikawa Salusse

    2016-05-01

    Full Text Available Due to the low consolidation of entrepreneurship teaching methodologies supported by consistent theoretical foundations, the objective of this research is to understand how professors teach entrepreneurship using effectuation theory. The research uses the multiple case study methodology – five teaching experiences in four different countries – in order to understand the context and the structure of the courses, the methodologies applied and the perception of professors regarding the teaching-learning experiences. As main results, it emphasizes the practice of the dynamic model of effectuation as the integrating element in all cases, the identification of emerging teaching methodologies and the categorization of teaching methodologies according to the dimensions and behavior associated with the theory. In addition, the study establishes initial relationships between effectuation and entrepreneurial intention and the need for the field to consider the individual´s personal history, such as culture and formal education, to be tested in future research.

  11. FUNDAMENTOS DEL PARADIGMA CUALITATIVO EN LA INVESTIGACION EDUCATIVA

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    Leda Badilla Chavarría

    2006-12-01

    Full Text Available La investigación cualitativa en el campo de la educación es un tema de interés actual, ya que está inmersa en nuestras prácticas profesionales cotidianas. El propósito de este intercambio investigativo permite reconstruir, articular y reflexionar sobre algunos tópicos que fundamentan el enfoque cualitativo de investigación y que están relacionados con nuestros escenarios habituales de trabajo. De manera que primero se realizará una aproximación, desde sus componentes epistemológicos y metodológicos, a la investigación cualitativa, para luego continuar caracterizando este enfoque desde la producción de la información, su análisis, las fuentes de credibilidad de los resultados y la ética que lo sustenta.

  12. Sistema imunitário: Parte I. Fundamentos da imunidade inata com ênfase nos mecanismos moleculares e celulares da resposta inflamatória Immune system: Part I. Fundamentals of innate immunity with emphasis on molecular and cellular mechanisms of inflammatory response

    Directory of Open Access Journals (Sweden)

    Wilson de Melo Cruvinel

    2010-08-01

    Full Text Available O sistema imunológico é constituído por uma intrincada rede de órgãos, células e moléculas, e tem por finalidade manter a homeostase do organismo, combatendo as agressões em geral. A imunidade inata atua em conjunto com a imunidade adaptativa e caracteriza-se pela rápida resposta à agressão, independentemente de estímulo prévio, sendo a primeira linha de defesa do organismo. Seus mecanismos compreendem barreiras físicas, químicas e biológicas, componentes celulares e moléculas solúveis. A primeira defesa do organismo frente a um dano tecidual envolve diversas etapas intimamente integradas e constituídas pelos diferentes componentes desse sistema. A presente revisão tem como objetivo resgatar os fundamentos dessa resposta, que apresenta elevada complexidade e é constituída por diversos componentes articulados que convergem para a elaboração da resposta imune adaptativa. Destacamos algumas etapas: reconhecimento molecular dos agentes agressores; ativação de vias bioquímicas intracelulares que resultam em modificações vasculares e teciduais; produção de uma miríade de mediadores com efeitos locais e sistêmicos no âmbito da ativação e proliferação celulares, síntese de novos produtos envolvidos na quimioatração e migração de células especializadas na destruição e remoção do agente agressor, e finalmente a recuperação tecidual com o restabelecimento funcional do tecido ou órgão.The immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. Innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. Its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. The organism first line of defense against

  13. Práticas educativas em saúde: da fundamentação à construção de uma disciplina curricular Prácticas educativas en la salud: del fundamento a la construcción de una asignatura Educational practice in health area: from the base to the construction of a curricular subject

    Directory of Open Access Journals (Sweden)

    Maria Helena Salgado Bagnato

    2009-09-01

    Full Text Available Este trabalho procura apresentar o processo de construção da disciplina Práticas Educativas em Saúde, introduzida no currículo implantado em 2006 e desenvolvida no Curso de Licenciatura em Enfermagem da Universidade Estadual de Campinas, Campinas, SP. O percurso desse trabalho passou pelas tentativas de aproximação entre a educação e a saúde e os aportes dos estudos culturais, atravessando esses campos disciplinares, sem perder o fio condutor de outras possibilidades para a construção do saber pedagógico na formação do enfermeiro. No decorrer da disciplina, foram abordados tópicos importantes, como as concepções de ser humano, de corpo, de saúde, a relação educação-saúde, dentre outros. Neste contexto, estabeleceram-se interlocuções com referenciais que movimentaram os paradigmas, os discursos e as práticas em saúde. Assim, nossa trajetória no pleito da disciplina possibilitou compreender a historicidade das práticas educativas em saúde e os pressupostos que as têm orientado para subsidiar análises críticas no desenvolvimento dessas práticas.Este trabajo busca presentar el proceso de construcción de la asignatura de Prácticas Educativas en la Salud, introducida en el curriculum implantado en 2006 y desarrollado en el Curso de Licenciatura en Enfermería de la Universidad Estatal de Campinas, Campinas, SP. El recorrido del presente trabajo pretende hacer una aproximación entre la Educación y Salud y los fundamentos de los Estudios Culturales, entrecruzando estos campos, sin perder el hilo conductor de otras posibilidades para la construcción del saber pedagógico en la formación del Enfermero(a. Durante el desarrollo de la asignatura, fueron abordados importantes temas como la concepción de ser humano, de cuerpo, de salud, la conexión entre la educación y la salud , entre otros. En este contexto, se establecieron interlocuciones con referenciales que movilizaron paradigmas, discursos y prácticas en

  14. Antipsicóticos de ação prolongada no tratamento de manutenção da esquizofrenia: Parte I. Fundamentos do seu desenvolvimento, benefícios e nível de aceitação em diferentes países e culturas Antisicóticos de acción prolongada en el tratamiento de matenimiento de la esquizofrenia: Parte I. Fundamentos de su desarrollo, beneficios y nivel de aceptación en diferentes países e culturas Long-acting antipsychotics in the maintenance treatment of schizophrenia: Part I. Foundations of its development, benefits and acceptance level in different countries and cultures

    Directory of Open Access Journals (Sweden)

    Luiz Paulo de C. Bechelli

    2003-06-01

    Full Text Available Neste trabalho são revistos os fundamentos do desenvolvimento dos antipsicóticos de ação prolongada, a aderência ao tratamento, fatores que dificultam o seguimento da prescrição e suas conseqüências, benefícios e aceitação dos antipsicóticos de ação prolongada. A partir dos dados desta primeira parte do trabalho, os seguintes pontos devem ser destacados: a taxa de não aderência ao tratamento na esquizofrenia é em torno de 60%; por se tratar de uma doença crônica com elevado risco de recaída, a manutenção do medicamento auxilia no seu controle. Os antipsicóticos de ação prolongada foram desenvolvidos exatamente com este objetivo: garantir a administração do medicamento e a sua regularidade, condições essenciais na prevenção da recaída. Apesar dos benefícios inestimáveis do antipsicóticos de ação prolongada, diversos fatores contribuíram para que tivessem uma utilização aquém do seu potencial.En este trabajo revisamos los fundamentos del desarrollo de los antisicóticos de acción prolongada, la adherencia al tratamiento, factores que dificultan el seguimiento de la prescripción y sus consecuencias, así como sus beneficios y aceptación. A partir de los datos de esta primera parte del trabajo, el siguiente punto necesita ser destacado: la tasa de no-adherencia al tratamiento en esquizofrenia está alrededor de 60%. Por tratarse de una enfermedad crónica, con riesgo elevado de recaída, el mantenimiento del medicamento ayuda en su control. Los antisicóticos de acción prolongada fueron desarrollados exactamente con este objetivo: garantizar la administración del medicamento y su regularidad, condiciones esenciales para prevenir la recaída. A pesar de los beneficios inestimables de los antisicóticos de acción prolongada, diversos factores han contribuido para que en su utilización no se aproveche todo su potencial.In this study, the foundations of long-acting antipsychotics development, the

  15. Los cuidados de nacimiento en Andalucía: Gestores del parto, técnicas, procedimientos y fundamentos teórico-metodológicos a través de la encuesta del Ateneo de Madrid de 1901-1902 Birth nursing care in Andalucia: childbirth agents, technologies, procedures and theoretical-methodological foundations across the 1901-1902 survey of the Ateneo de Madrid cultural club

    Directory of Open Access Journals (Sweden)

    Manuel Jesús Salas Iglesias

    2004-06-01

    Full Text Available La sección de Ciencias Morales y Políticas del Ateneo de Madrid promovió en 1901 una gran encuesta relativa a costumbres populares de nacimiento, matrimonio y muerte en España. Este documento se perfila como una interesante fuente de análisis crítico para la Historia de la Enfermería, por cuanto es consustancial al ciclo vital una demanda universal de Cuidado. Así, uno de los apartados concernientes al nacimiento, refiere, de modo explícito, a los gestores del parto. El presente análisis trata de desvelar datos concernientes a los cuidados de nacimiento en Andalucía a finales del siglo XIX y principios del siglo XX, examinando a sus gestores, procedimientos y fundamentos teórico-prácticos. Por otra parte perseguimos encontrar en la Historia de la Enfermería esa especialidad al servicio de la disciplina que nos permita definir la dimensión abstracta del concepto de Cuidado.The Moral and Political Sciences section of the "Ateneo de Madrid" cultural club promoted in 1901 a great survey relative to popular customs of birth, marriage and death in Spain. This document is outlined as an interesting source of critical analysis for the nursing History, since it´s consubstantial to the vital cycle a universal Care demand. This way, one of the paragraphs relating to the birth, recounts of explicit way the childbirth agents. The present analysis tries to reveal relating information to birth nursing care in Andalucia at the end of the 19th century and principles of the 20th century, examining to its agents, procedures and theoretical - practical foundations. On the other hand, we chase to find in the nursing History this speciality to the service of the discipline, that allows us to define the abstract dimension of the Care concept.

  16. Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women.

    Science.gov (United States)

    Lee, J H; Kim, S; Kim, M K; Yun, B H; Cho, S; Choi, Y S; Lee, B S; Seo, S K

    2018-02-01

    Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. This study used data from the Korea National Health and Nutrition Examination Survey 2008-2011. Participants were 3744 postmenopausal Korean women. Sarcopenia was defined as appendicular skeletal muscle mass divided by body weight >1 standard deviation below the mean for women aged 20-40 years. The serum 25-hydroxyvitamin D and fasting insulin levels were measured, and insulin resistance was calculated using the formula: fasting plasma glucose (mg/dl) × fasting insulin (mIU/l)/405. We found a strong inverse association between 25-hydroxyvitamin D concentration and sarcopenia in postmenopausal Korean women (p = 0.0009). There was also a significant association between sarcopenia and insulin resistance, independent of vitamin D and obesity status (p < 0.0001). However, there was no significant association between 25-hydroxyvitamin D concentration and insulin resistance. In the subgroup analysis, insulin resistance was found to be determined by sarcopenic rather than vitamin D status. Sarcopenia was associated with both insulin resistance and 25-hydroxyvitamin D concentration in postmenopausal Korean women, regardless of obesity status. However, 25-hydroxyvitamin D concentration was not associated with insulin resistance. Sarcopenia is therefore of greater clinical importance due to its close relationship with insulin resistance.

  17. Study and radiological impact assesstment produced by activities of different non-nuclear industries. Titanium dioxide industries; Estudio y evaluacion del impacto radiologico producido por las actividades de diversas industrias no nucleares en el sur de Espana. Industrias de dioxido de titanio

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Tenorio, R.; Manjon, G.; Abril, J.M. (and others)

    2010-07-01

    After a careful study and evaluation of radiological impact, the conclusiono is that these industries do not need to be subject to control, and it is not necessary any corrective action to reduce the exposition and/or to apply any radiation protection measures.

  18. Redes sociais e teoria social: revendo os fundamentos do conceitoRedes Sociales y Teoría Social: Reviendo los fundamentos del concepto

    Directory of Open Access Journals (Sweden)

    Sonia Acioli

    2007-12-01

    Full Text Available Este artigo discute os vários usos e abordagens utilizadas em relação à expressão redes sociais, que tem sido naturalizada e associada apenas às tecnologias da informação. É um estudo conceitual que pretende situar historicamente a noção de redes, buscando ainda identificar as formas as quais a expressão redes sociais tem sido articulada e as abordagens empreendidas. Para tal, foi realizada uma revisão bibliográfica tendo como base os campos da Sociologia, Antropologia, Informação e Comunicação por serem essas as áreas aonde a noção de redes teve sua origem sendo também mais freqüentemente utilizada. Buscando pensar as possibilidades de análise utilizando a noção de rede, esboçamos três possíveis abordagens inspiradas na leitura de Barnes, J. A. e Mitchell, J. Clyde. São elas: uma abordagem metafórica, voltada à filosofia de rede ou ainda a uma aproximação conceitual; uma analítica centrada na metodologia de análise de redes, e, uma tecnológica, cuja preocupação está voltada para as redes de conexões, para as possibilidades que se colocam em relação às interações possíveis na sociedade através de redes eletrônicas, de informações, interorganizacionais. Entendemos que em todas essas abordagens dá-se uma relação direta com a informação, se percebemos informação como processo de troca permanente. Portanto, trabalhar com a idéia de redes significa trabalhar de forma articulada com a idéia de informação. Concluindo, nesse mundo em redes, onde há mais quantidade do que qualidade de informação, a possibilidade de fragmentação de saberes e culturas, e, portanto de sujeitos é muito grande. Nesse sentido, pode-se pensar na relativização dos espaços internos - entendidos como o local – além da valorização desses mesmos espaços, já que as ordens local e global se interpenetram e podem reinventar formas de comunicação e saberes.

  19. DRENAJE QUIRÚRGICO EXTRAPERITONEAL DE ABSCESO DEL PSOAS: FUNDAMENTO ANATÓMICO. Drenaje quirúrgico extraperitoneal de absceso del psoas: Fundamento anatómico

    Directory of Open Access Journals (Sweden)

    Alejandro M Russo

    2016-03-01

    Full Text Available El espacio extraperitoneal se encuentra delimitado por el peritoneo parietal y las paredes de la cavidad abdómino-pélvica. Al igual que la cavidad peritoneal este espacio puede ser asiento de diversas colecciones, como ser hematomas, tumores y supuración. Con el advenimiento de las nuevas técnicas de imagen, se ha contribuido no solo al mejor diagnóstico de estas patologías sino también a su mejor manejo. El objetivo de este trabajo es mostrar la anatomía del abordaje extraperitoneal del comparti-miento del psoas y su aplicación al tratamiento de un paciente. Para esto se utilizaron 5 cadáveres adultos fijados previamente en solución en base a formol. Se realizó disección bilateral de la pared antero-lateral del abdomen reclinando la bolsa peritoneal para a continuación abordar el compartimiento del músculo psoas. Este conocimiento fue utilizado en el tratamiento quirúrgico de una paciente que consultó por un absceso del compartimiento del psoas derecho. En las preparaciones cadavéricas, se observó cómo al rebatir el peritoneo parietal se expone la totalidad del compartimiento muscular del psoas. Este procedi-miento fue realizado a la paciente consiguiendo el drenaje completo de la cavidad abscedada, quien tuvo una buena evolución y fue dada de alta a los 7 días. Los hallazgos demuestran una vez más como el conocimiento anatómico sigue estando vigente en la práctica clínica, siendo la comprensión del espacio extraperitoneal fundamental no solo para el anatomista sino también para el cirujano.  The retroperitoneal space is bounded by the parietal peritoneum and the posterior abdominal wall. Just like the peritoneal cavity, this region can host multiple effusions such as hematomas, tumors and suppuration. With the development of new radiological technics, both diagnosis and management of these conditions has improved. The purpose of this paper is to demonstrate the anatomy of the extraperitoneal approach of the psoas compartment and its application to a patient´s surgical treatment. For this purpose 5 formalin-fixed adult cadavers were used. Bilateral dissection of the antero-lateral abdominal wall was performed in every specimen. Once the parietal peritoneum was mobilized the psoas compartment was approached. This knowledge was used during the surgical treatment of a patient who attended to the emergency room with a right psoas compartment abscess. In the cadaveric specimens, the psoas muscular compartment was approached after mobilizing the parietal peritoneum medially. This procedure was carried out in the patient resulting in complete drainage of the purulent effusion. The patient had complete relief of the symptoms and was discharged 7 days after the procedure. These findings show that the anatomic knowledge is still important in clinical practice. Understanding the extraperitoneal space is crucial for both anatomists and surgeons. 

  20. Fundamentos y modalidades de la tutoría en educación superior / Fundamentos e modalidades da tutoria em educação superior

    Directory of Open Access Journals (Sweden)

    Ida Lucía Morchio

    2009-01-01

    Full Text Available La Tutoría en Educación Superior constituye una vía para contribuir al logro de la calidad educativa en términos de aprendizaje efectivo y promoción del desarrollo personal de los estudiantes. En el presente trabajo se recupera su etimología, se propone una conceptualización, se analizan sus bases teóricas desde la perspectiva de la Orientación Educativa y de la Psicología de la Educación y se describen algunas modalidades de implementación. Como cierre se comparten experiencias realizadas en la Facultad de Filosofía y Letras de la UNCuyo (Mendoza, Argentina.A tutoria em Educação Superior constitui uma via para atingir a qualidade educativa em termos de aprendizado efetivo e promoção do desenvolvimento pessoal dos estudantes. No presente trabalho recupera-se sua etimologia, propõe-se uma conceitualização, analisam-se suas bases teóricas desde a perspectiva da Orientação Educativa e da psicologia da Educação e se descrevem algumas modalidades de implementação. No final, partilham-se experiências realizadas na Faculdade de Filosofia e Letras da Universidade Nacional de Cuyo (UNCuyo, Mendoza, Argentina.

  1. Fundamentos de largo plazo de la crisis económica del 2008

    OpenAIRE

    David Mayer Foulkes

    2015-01-01

    The 2008 economic crisis has long-term causes that are rooted in the economic dynamics of globalization. I construct a Solow-style endogenous model of capital accumulation, technological change, trade and cheap-factor-seeking foreign direct investment (FDI), based on myopic agents. Combining advanced technologies with low costs, FDI yields extraordinary profits that generate asymmetric innovation incentives that explain the following stylized facts. Globalization (a) increases capital accumul...

  2. Transtornos alimentares: fundamentos históricos Eating disorders: historical background

    Directory of Open Access Journals (Sweden)

    Táki Athanássios Cordás

    2002-12-01

    Full Text Available Os autores fazem uma breve revisão dos aspectos históricos dos transtornos alimentares. Possíveis correlaç��es psicopatológicas com os conceitos diagnósticos atuais são discutidas.The authors make a brief review of the historical aspects of eating disorders. Possible correlations with modern psychopathological aspects are commented

  3. Integrated power system using environmental engineering foundations; Sistema integrado de energia usando fundamentos de engenharia ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Moura, J P; Pannir Selvam, P V.P. [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

    2006-07-01

    The paper presents the study of reuse of organic waste in rural communities, particularly in micro-plants applying the concept of cleaner production, seeking low cost technological innovation. Also, this article presents: study of the process of reusing biomass waste; study on alternative energy sources as viable energy sources for small-scale process; study of new technologies for organic residues reuse with aerobic degradation and anaerobic digestion to produce biogas and fertilizer; study of energy consumption of local agricultural industry, seeking solutions for thermal system, allied to a study of technical and economic feasibility based on the use of organic waste.

  4. Fundamentos psicopedagógicos de las inteligencias múltiples

    OpenAIRE

    Ferrándiz, Carmen; Prieto, María Dolores; Bermejo, María Rosario; Ferrando, Mercedes

    2006-01-01

    El objetivo del trabajo es estudiar las raíces psicopedagógicas del modelo de las Inteligencias Múltiples. Analizamos los datos procedentes de nuestro estudio realizado con 294 alumnos (preescolar y primeros niveles de educación primaria). Es hacia 1983 cuando Gardner publica su libro titulado Estructura de la Mente, donde propone la existencia de siete inteligencias, que más tarde amplia a ocho (lingüística, lógico-matemática, visoespacial, corporal-cinestésica, musical, interpersonal, i...

  5. La Valoración. Fundamento teórico de la Archivística.

    Directory of Open Access Journals (Sweden)

    José Bernal Rivas Fernández

    2011-08-01

    una profunda reflexión. Por lo que se hará un análisis de los enfoques más recientes en cuanto a la valoración y el impacto de las nuevas tecnologías de la información, como uno de los retos que se le presenta a la Archivística en la sociedad de la información.

  6. LA CULTURA ORGANIZACIONAL EN EL DESARROLLO DE EMPRESAS INTELIGENTES. FUNDAMENTOS: VALORES, COMUNICACIÓN Y LIDERAZGO

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    Patricia Gillezeau

    1999-07-01

    Full Text Available El propósito del estudio es establecer la presencia de valores compartidos, una comunicación humanizada, un liderazgo transformacional y el grado de satisfacción de clientes externos y proveedores en la cultura de empresas inteligentes. Para ellos, se utilizó la metodología cualitativo - interpretativo, método de medición cuando se involucra al ser humano. Del análisis realizado se concluyó que la cultura enraizada en valores, regula los factores expresivos, afectivos y de comportamiento en las organizaciones. Su comprensión y aplicación dependerá de una red comunicación humanizada, un liderazgo transformacional y un alto grado de satisfacción e involucramiento de clientes y proveedores. Elementos inteligentes.

  7. El fundamento humanista del pensamiento de izquierda latinoamericano. ¿De qué humanismo hablamos?

    Directory of Open Access Journals (Sweden)

    Dra. Vilda Rodríguez-Méndez

    2015-10-01

    Full Text Available La cuestión del humanismo ocupa un importante lugar en los estudios latinoamericanos actuales, sin embargo, la reflexión teórica en torno a esta problemática no ha conseguido la atención que la actualidad está demandando de los investigadores. En el presente estudio se hace un análisis de los factores que, a juicio de la autora, influyen en la visión fragmentada y parcial que prevalece en el enfoque histórico del humanismo, particularmente aquellos que han dejado su huella en las investigaciones cubanas, las cuales han estado fuertemente influenciadas por la visión del marxismo. Al mismo tiempo, se propone la consideración de algunos elementos, esenciales para la comprensión más cabal del humanismo, desde una perspectiva que integre la historia con la lógica del propio concepto.

  8. Fundamentos de las normas de descripción archivística y bibliotecaria

    Directory of Open Access Journals (Sweden)

    Carlos Oliva Marañón

    2015-01-01

    Full Text Available Los archivos, las bibliotecas y los centros de documentación han aumentado su visibilidad en Internet durante los últimos años para interactuar con los usuarios y aproximarles a los fondos documentales en formato digital. La normalización es toda actividad colectiva dirigida a establecer e implementar normas para definir los requisitos que deben cumplir bienes, servicios y procedimientos. Esta investigación desarrolla las principales normas de descripción archivística (NEDA, ISAD y bibliotecaria (ISBD, MARC. Este proceso se considera una operación de análisis documental que respeta el principio de procedencia. Las especiales características del documento de archivo; la adaptación de las normas al fondo documental pertinente; la dificultad de la coherencia y la cohesión normativa; el aumento de volumen de trabajo; el alto coste económico; y la gestión del tiempo constituyen los principales inconvenientes para satisfacer adecuadamente las necesidades de información de los usuarios.

  9. Fundamentos e métodos de medidas de energia dinâmica no SPT

    Directory of Open Access Journals (Sweden)

    Antonio Belincanta

    2000-05-01

    Full Text Available Discutem-se neste trabalho os métodos disponíveis no Brasil e no exterior para a medida da energia transferida às hastes no SPT, apresentando-se inclusive registros típicos dos eventos dinâmicos correspondentes

  10. Fundamentos para la creación de actividades con material real

    Directory of Open Access Journals (Sweden)

    Román Navarro Giner

    2008-01-01

    Full Text Available En esta experiencia práctica pretendemos mostrar algunas pautas para transformar cualquier material real atractivo para el profesor en actividades aplicables a la clase de español, basándonos en las directrices propuestas por el Marco común europeo de referencia para las lenguas (MCER y teniendo en cuenta los contenidos que marcan los Niveles de Referencia (en adelante, NR del Instituto Cervantes. Para ello se comentarán en primer lugar las particularidades teóricas que la actividad requiere, para ver a continuación un ejemplo de diseño de actividad en el que combinaremos un microcuento, un artículo periodístico, el concurso de un periódico en internet y el uso de la mensajería móvil.

  11. Fundamentos para la creación de actividades con material real

    Directory of Open Access Journals (Sweden)

    Román Navarro Giner

    2012-08-01

    Full Text Available En esta experiencia práctica pretendemos mostrar algunas pautas para transformar cualquier material real atractivo para el profesor en actividades aplicables a la clase de español, basándonos en las directrices propuestas por el Marco común europeo de referencia para las lenguas (MCER y teniendo en cuenta los contenidos que marcan los Niveles de Referencia (en adelante, NR del Instituto Cervantes. Para ello se comentarán en primer lugar las particularidades teóricas que la actividad requiere, para ver a continuación un ejemplo de diseño de actividad en el que combinaremos un microcuento, un artículo periodístico, el concurso de un periódico en internet y el uso de la mensajería móvil.

  12. El diseño de revistas como lenguaje: fundamentos teóricos

    OpenAIRE

    Subiela Hernández, Blas José

    2010-01-01

    El objeto de estudio de la presente tesis es el diseño de revistas, una actividad incluida dentro del diseño periodístico, pero que, dentro de esta disciplina, ha recibido menos atención que el diseño de la prensa diaria. Partimos de la hipótesis de que el diseño en las revistas se puede considerar un lenguaje, con capacidad para transmitir sentido. Para confirmar nuestra hipótesis realizamos una investigación teórica y argumentativa que persigue tres objetivos: En primer lugar, defi...

  13. FUNDAMENTOS ÉTICOS DE LA GESTIÓN DEL RIESGO

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    Gustavo Wilches-Chaux

    2005-01-01

    Full Text Available Especialistas en gestión del riesgo concuerdan en que la humanidad será testigo de nuevos y mayores desastres, tendencia que viene en aumento desde la última década. Esto se debe, por una parte, al incremento de la población humana en condiciones de vulnerabilidad y, por otra, a que los fenómenos de la naturaleza están incrementando su poder destructivo. El autor de este artículo se encuentra entre quienes interpretan esto último como una expresión del sistema inmunológico de la biosfera intentando deshacerse de una especie que, por una parte, constituye "la obra maestra" del Cosmos, pero que simultáneamente ha adquirido la condición de plaga. Una de las claves de la supervivencia de nuestra especie en el planeta está en la Ética.

  14. El marketing en las ONG´s. Fundamentos y características

    OpenAIRE

    Luis-Ángel Sanz de la Tajada

    2009-01-01

    Uma ONG é uma organização cujo objetivo é o interesse coletivo, que presta serviços sem fins lucrativos e que é financiada através da arrecadação de fundos, tanto públicos quanto privados. O marketing aplicado em sua atuação é o chamado marketing não empresarial, de caráter não lucrativo e seu referente é o marketing de serviços. A importancia do marketing social e sua relação específica com as causas sociais têm levado muita gente a identificar o marketing praticado pelas ONGs com este impor...

  15. Fundamentos de um Programa de Avaliação Educacional

    Directory of Open Access Journals (Sweden)

    Heraldo Marelim Vianna

    2009-01-01

    Full Text Available O artigo oferece reflexões sobre aspectos da avaliação educacional e procura estimular diferentes pensares sobre a definição de uma política de avaliação do sistema educacional brasileiro. Destaca, inicialmente, a relação entre avaliação e planejamento escolar; associa a idéia de avaliação a uma efetiva política de ação e procura estimular estudos sobre as possibilidades dos testes referenciados a critério. O trabalho chama a atenção para a influência da diversidade socioeconômica e cultural nas avaliações e mostra o significado da avaliação na tomada de decisões. A questão da disseminação dos resultados é vista como ponto fundamental no impacto da avaliação sobre os sistemas educacionais. Outros aspectos relacionados à temática geral sobre “padrões e avaliação” são igualmente considerados.

  16. Planes de seguridad del agua. Fundamentos y perspectivas de implementación en Colombia

    Directory of Open Access Journals (Sweden)

    Andrea Pérez Vidal

    2009-09-01

    Full Text Available El agua para consumo humano debe estar libre de organismos patógenos, sustancias químicas, impurezas y cualquier contami- nante que cause problemas a la salud humana. América Latina y el Caribe (ALC presentan problemas de calidad por deficien- cias en la operación, mantenimiento y continuidad de los servicios, incorrecto funcionamiento de las plantas de tratamiento y precariedad de las redes de distribución e instalaciones domiciliarias. Las tendencias mundiales del sector agua potable están o- rientadas al desarrollo de metodologías para evaluación y gestión del riesgo en los sistemas de abastecimiento para proteger la salud pública. La aplicación de los Planes de Seguridad del Agua (PSA es una práctica orientada al suministro de agua de cali- dad, cuya estructura se basa en principios de barreras múltiples, análisis de peligros, puntos críticos de control (APPCC y hacer- camientos sistemáticos de gestión como la ISO 9001:2000. Experiencias internacionales han demostrado los beneficios de im- plementarlos como estrategia para garantizar la calidad del agua potable y la protección de la salud pública. En Colombia, la actual normatividad sobre agua potable exige la implementación de mapas de riesgos y evaluación de índices de calidad, lo que posibilitará que los PSA tengan gran perspectiva de implementación en el corto plazo.

  17. FUNDAMENTOS Y MODALIDADES DE LA TUTORÍA EN EDUCACIÓN SUPERIOR

    Directory of Open Access Journals (Sweden)

    Ida Lucía Morchio

    2009-12-01

    Full Text Available La Tutoría en Educación Superior constituye una vía para contribuir al logro de la calidad educativa en términos de aprendizaje efectivo y promoción del desarrollo personal de los estudiantes. En el presente trabajo se recupera su etimología, se propone una conceptualización, se analizan sus bases teóricas desde la perspectiva de la Orientación Educativa y de la Psicología de la Educación y se describen algunas modalidades de implementación. Como cierre se comparten experiencias realizadas en la Facultad de Filosofía y Letras de la UNCuyo (Mendoza, Argentina.

  18. MAPEANDO FUNDAMENTOS DO CONSTRUCTO NEUROMARKETING COM PROFISSIONAIS DE EMPRESAS DE PUBLICIDADE

    Directory of Open Access Journals (Sweden)

    Thiago Ferreira Dias

    2011-12-01

    Full Text Available O presente artigo tem por objetivo conhecer o nível de domínio e influência do constructo neuromarketing junto a profissionais de agências publicidade no Brasil. O arcabouço teórico foi construído a partir dos estudos sobre a ciência do cérebro voltados para o conhecimento de experiências inconscientes dos consumidores, as quais são responsáveis por impulsionar as suas tomadas de decisões e comportamentos de compra. Tais novidades relacionam-se ao Neuromarketing que, através das técnicas de neuroimagem, como a FMRI, a PET e o FDOT. Foram realizadas entrevistas em profundidade com os gerentes da área de planejamento das principais agências de publicidade do Brasil, e posterior análise de conteúdo. Observou-se que mesmo cientes das limitações dos atuais instrumentos de pesquisa e da constante busca por novas tecnologias, as agências de publicidade não conhecem totalmente os conceitos relacionados ao neuromarketing. Observa-se resistência ao uso das técnicas, juntamente com os questionamentos e o pouco conhecimento do assunto fazem com que a influência do neuromarketing não seja sentida de forma prática no meio publicitário. Os resultados apontam o domínio do constructo neuromarketing nas agências de publicidade brasileira é apenas teórico, pois, pouco se conhece a respeito dos estudos neurológicos e, absolutamente nada, das técnicas de neuroimagem.

  19. Modelos contínuos do solvente: fundamentos Continuum solvation models: fundamentals

    Directory of Open Access Journals (Sweden)

    Josefredo R. Pliego Jr

    2006-06-01

    Full Text Available Continuum solvation models are nowadays widely used in the modeling of solvent effects and the range of applications goes from the calculation of partition coefficients to chemical reactions in solution. The present work presents a detailed explanation of the physical foundations of continuum models. We discuss the polarization of a dielectric and its representation through the volume and surface polarization charges. The Poisson equation for a dielectric was obtained and we have also derived and discuss the apparent surface charge method and its application for free energy of solvation calculations.

  20. Fundamentos para un estudio del guion en el cine chileno: notas preliminares

    OpenAIRE

    Rubén Dittus Benavente

    2015-01-01

    El artículo presenta el marco teórico para estudiar los modelos de guion en el cine chileno de ficción. La literatura publicada y el creciente interés en la formación de guionistas en la industria audiovisual, tanto en Chile como en el extranjero, dan cuenta de la necesidad de abordar los principios dramatúrgicos y los estándares profesionales desde una mirada integradora, que supere los clásicos modelos de escritura creativa. Más allá de las divergencias o acuerdos de dichas teorías, el guio...

  1. Theory for the mechanics use of Meissner effect; Fundamentos para el uso mecanico del efecto Meissner

    Energy Technology Data Exchange (ETDEWEB)

    Diaz Lopez, V; Perez Diaz, J L [Universidad Carlos III. Madrid (Spain)

    1998-06-01

    An expression is derived which describes the force excerpted by a magnetic field on a perfect superconductor (type I with infinite critical field and current) as a function of the superconductor shape and of the magnetic field in the absence of the superconductor or when the superconductor is in its normal (non-superconducting) state. This expression permits the optimisation of both magnetic field and superconductor shape which is a prerequisite for possible engineering applications. (Author) 7 refs.

  2. La formación integral en Dios como fundamento del desarrollo personal y social

    OpenAIRE

    Flórez Luna, Carlos Alberto

    2015-01-01

    Este texto pretende mostrar la importancia de una formación integral basada en principios morales y espirituales que orienten al individuo hacia el desarrollo armonioso del ser, teniendo en cuenta las diferentes dimensiones del ser humano. Por lo tanto, se abordan de manera directa el concepto de formación integral y sus implicaciones en el contexto social.

  3. Fundamentos de la transparencia en la sociedad contemporánea

    Directory of Open Access Journals (Sweden)

    Ricardo Uvalle Berrones

    2016-01-01

    Full Text Available El objetivo de este texto es analizar la relevancia de la transparencia en el ámbito de la sociedad contemporánea, puntualizando que su reconocimiento como política pública ha implicado que se vincule a formas de poder con apertura y publicidad restringidos, hasta estructurarse con los valores y prácticas de la democracia moderna, como medio que hace posible la vigencia del derecho de acceso a la información, combinando oportunidades y restricciones de carácter institucional. La hipótesis del trabajo es que la transparencia controla al poder del Estado y sin embargo, no se explica por sí misma, sino en relación con el secreto y desde que la publicidad coadyuva a que los ciudadanos accedan, conozcan y evalúen la información que las oficinas gubernamentales producen, entendida desde una perspectiva conceptual de políticas públicas. El trabajo utiliza los métodos de interpretación y exposición para generar conocimiento teórico normativo. Las conclusiones se relacionan con la utilidad de la transparencia para institucionalizar un poder abierto, accesible, público y responsable.

  4. Una visión orteguiana del fundamento del derecho a la vida

    OpenAIRE

    Marcos del Cano, Ana María

    2007-01-01

    En este trabajo quiero estudiar el significado de la expresión “vida” cuando es utilizada como “derecho a la vida”. De hecho, este tema es muy interesante, especialmente si nos damos cuenta de que existe mucha ambigüedad sobre lo que “derecho a la vida” significa, sobre todo desde que la medicina moderna puede salvar más vidas que hace diez años, con el uso de nuevas tecnologías. “Vida” es un concepto interdisciplinario. Surge en diferentes áreas, como el Derecho, la Filosofía, la Medicina, l...

  5. Fundamento y límites de la potestad sancionadora administrativa en materia ambiental

    OpenAIRE

    Bermúdez Soto,Jorge

    2013-01-01

    El ejercicio de la potestad sancionadora de la Administración del Estado en el ámbito ambiental es manifestación de la importancia que la protección del medio ambiente ha adquirido en la sociedad y de la asunción de la misma como función pública. El ejercicio de este poder se encuentra limitado tanto por los principios generales aplicables, pero además se somete a límites específicos al ámbito ambiental. Dichos límites pueden ser categorizados en tres clases: orgánicos, procedimentales y sust...

  6. Fundamentos teológicos de la censura en Francisco Suárez

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    Manuel Lázaro Pulido

    2017-09-01

    Full Text Available La censura es un acto recogido dentro del Código de Derecho Canónico. La teología subyacente se inscribe dentro de la historia de la salvación propia del concilio Vaticano II. Varios siglos antes, el maestro jesuita Francisco Suárez reflexionó sobre la censura en un voluminoso tratado (Disputationum de censuris…, en el que anticipa los elementos pertenecientes a la censura que aparecen en el actual CDC. Suárez realiza una lectura teológica en el que destaca el carácter medicinal de la censura, a partir de la lectura sacramental de la pena y desde un antropología de la voluntad, que supone una apuesta por la prevención del hombre y su salvación, antes que por su carácter penal, o si se quiere por dotar a la ley penal de un carácter salvífico.

  7. Los nuevos fundamentos de la regulación privada transnacional

    Directory of Open Access Journals (Sweden)

    Fabrizio Cafaggi

    2014-06-01

    Full Text Available En la sección I de este artículo los factores que dirigen el surgimiento de la nueva Regulación Privada Transnacional son identificados en comparación con, de una parte, el derecho de los mercados y, de la otra, el régimen público internacional. En la sección II, la discusión se centra en la esfera privada, analizando los dos conflictos de interés que surgen de las relaciones entre regulado y regulador y la necesidad de respuestas desde la regulación. En la sección III, se analiza la complementación entre los regímenes públicos y privados. A la luz de esta aproximación en el presente texto se defiende el argumento de la existencia de diferencias entre lo público y lo privado en el ámbito global. La diferencia entre lo público y lo privado se analiza comparando el ámbito doméstico con el transnacional. Cuatro modelos diferentes son identificados: hibridación, creación normativa por colaboración, coordinación y competencia. La sección IV resume los resultados del análisis realizado, reconsiderando las relaciones entre lo público y lo privado en el nivel transnacional.

  8. Fundamentos de los sistemas de alerta en las entidades de supervisión bancaria

    OpenAIRE

    Carrasco Gallego, Amalia

    1999-01-01

    Las autoridades supervisoras de algunos países utilizan la forma más o menos genuina el denominado sistema CAMEL, donde la solvencia, rentabilidad y liquidez, se interrelacionan, adquiriendo un papel principal la calidad de la gestión para valorar la marcha de la entidad. Este método ha sido objeto de numerosas investigaciones para incorporarlo, de forma simplificada y a través de ratios, dentro de los sistemas de alerta que utilizan preventivamente las autoridades supervisoras.En este artícu...

  9. Marketing Ético como Fundamento del Bien Común en Organizaciones Humanas

    Directory of Open Access Journals (Sweden)

    Alejandro Fernández Baptista

    2014-01-01

    Full Text Available Los hombres poseen necesidades que deben ser satisfechas con el objeto de lograr una vida cónsona con los principios básicos de dignificación de la persona humana, alimento, vestido, medicamentos, comunicación, entretenimiento, transporte, entre otras, son algunas de las necesidades básicas que los seres humanos día tras día se esfuerzan por cubrir mediante el trabajo digno, utilizando para ello las potencialidades propias de cada quien. Las organizaciones modernas por medio del marketing como proceso administrativo, pretende lograr la satisfacción de tales necesidades por medio de la identificación oportuna de dichos requerimientos, elaborando productos y servicios que los satisfagan al crear una propuesta de valor superior a tales expectativas. Sin embargo, tal propuesta debería estar inmersa dentro de parámetros éticos y morales, las cuales garanticen la correcta utilización de cada uno de los elementos de la mezcla de mercadotecnia, producto, precio, promoción y la distribución. De esta manera los gerentes de marketing al momento de tomar decisiones éticas sobre estos tópicos, permitirían en desarrollo de organizaciones humanas promotoras del bien común dentro del contexto donde se desenvuelvanPalabras Clave: Marketing ético; Bien Común; Organizaciones Humanas. Marketing Ethical as the Foundation of the Common Wealth on Human OrganizationsAbstractThe people have needs that must be met for a life in keeping with the basic principles of dignification of the human person, food, clothing, medicines, communication, entertainment, transportation, among others, are some of the basic needs of human beings every day strive to cover using decent, using work of their own potential each person. Modern organizations marketing as administrative process aims at achieving the satisfaction of those needs in the timely identification of those requirements, developing products and services satisfying them to create a proposal for a value exceeding those expectations. Modern organizations aims marketing as administrative process at achieving the satisfaction of those needs in the timelyidentification of those requirements, developing them satisfying products and services to create a proposal for a value exceeding those expectations. However, such a proposal should be immersed within ethical and moral parameters, which ensure the correct use of each of the elements of the mix of marketing, product, price, promotion and distribution. However, such a proposal should be immersed within ethical and moral parameters, which ensure the correct use of each of the elements of the mix of marketing, product, price, promotion and distribution. Thus when marketing managers make ethical decisions on these topics, would enable developing funding human organizations who promotes the common wealth the context of where she is possible. Thus marketing managers make when to ethical decisions on these topics, woulda enable human funding organizations developing who promotes the context of the common wealth where she is possible.Keywords: Ethical Marketing; Common Wealth; Human Organizations.

  10. Fundamentos de Marketing. Tema 1: Introducción al marketing

    OpenAIRE

    Juan Vigaray, María Dolores de

    2012-01-01

    T1. Introducción al Marketing. Conceptos básicos: producto, bien, servicio, idea, experiencia, necesidades, demanda, deseos, mercado, evolución del concepto de marketing, enfoques de marketing, intercambio, utilidades, tendencias en marketing.

  11. El marketing en las ONG´s. Fundamentos y características

    Directory of Open Access Journals (Sweden)

    Luis-Ángel Sanz de la Tajada

    2009-01-01

    en un entorno competitivo frente a otras ONG´s. En consecuencia, el objetivo a alcanzar es la ayuda social compatible con el interés particular de la ONG por su propio desarrollo, lo que desemboca en un beneficio para ciertos pueblos junto con la obtención de poder para la ONG. Con el marketing social se pretende el beneficio para los ciudadanos (exclusivamente para ellos mientras que, con sus acciones de marketing, las ONG’s pretenden algo más: el beneficio para ciertos pueblos (marginados y necesitados de ayudas pero también el incremento del poder público y económico (¿político también?... para la propia ONG. Palabras clave: Marketing, Organización no Gubernamental (ONG, marketing no lucrativo, marketing no empresarial, marketing de organizaciones no lucrativas, marketing social, marketing público, marketing de servicios, marketing con causa, cambio social, filantropía, fundrising, comercio justo.

  12. La risa natal. Fundamentos antropológicos y religiosos de la comicidad clerical en Navidad

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    del Campo Tejedor, Alberto

    2014-12-01

    Full Text Available The comicalness of many of the popular and clerical festivals in the winter cycle has been mostly interpreted as a pagan and profane survival, objected to Christian faith. This paper discusses this simplistic thesis and adduces evidences that allows to understand the struggles between detractors and sympathizers of the polemic burlesque festivals on Christmas. We study the type of paschal joy that certain theology has justified in consideration of reasons such as the eutrapelia or the exemplary character of the humiliation and the humility in rituals based on investment of roles. Christmas laugh appears then as a fundamental ingredient of a mytho-logic in which turbulence, joviality, even obscenity, constitute liminal forms in collaborating with the eternal cycle of birth, death and resurrection.La comicidad de muchas de las fiestas populares y clericales del ciclo invernal ha sido interpretada mayoritariamente como supervivencia pagana y profana, contraria a la fe cristiana. Este artículo discute esta tesis reduccionista y aporta evidencias que permiten comprender las pugnas entre detractores y simpatizantes de las polémicas fiestas burlescas en torno a la Navidad. Para ello se indaga el tipo de alegría pascual que cierta teología ha justificado en atención a razones como la eutrapelia o el carácter ejemplar de la humillación y la humildad en los rituales de inversión de roles. La risa navideña se muestra como un ingrediente fundamental de una mito-lógica en la que la turbulencia, la jovialidad, incluso la obscenidad, constituyen formas liminales de colaborar en el eterno ciclo de nacimiento, muerte y resurrección.

  13. Necessidades proteicas, morbidade e mortalidade no paciente grave: fundamentos e atualidades

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    Haroldo Falcão Ramos da Cunha

    2013-03-01

    Full Text Available Evidências recentes sugerem que o balanço proteico negativo secundário à doença grave se associa ao aumento de morbidade. A perda da proteína corporal total é inevitável nesse cenário, mesmo com uma abordagem nutricional agressiva, e resulta, principalmente, do catabolismo da fibra muscular esquelética. O principal mecanismo bioquímico e metabólico envolvido nesse processo é o sistema ubiquitina-proteassoma, que, paradoxalmente, consome a adenosina trifosfatocomo fonte energética e motriz. É possível que a neutralidade do balanço proteico nessas instâncias clínicas, seja tão importante na melhora dos desfechos quanto atingir a meta calórica estimada ou medida pela calorimetria indireta. Estudos recentes apontam a utilização de concentrações mais elevadas de proteínas na terapia nutricional do paciente grave como importante para um impacto positivo na mortalidade. A proposta deste trabalho foi revisar alguns princípios da terapia nutricional relativos ao metabolismo proteico, sinalizar para as principais assertivas das diretrizes das sociedades especializadas e comentar estudos recentes, que abordam a questão em tela, sob a visão crítica da experiência clínica dos autores.

  14. Fundamentos jurídicos de la responsabilidad extracontractual del Estado en el Derecho argentino

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    Carlos Botassi

    2011-12-01

    Full Text Available En la República Argentina, el dogma de la irresponsabilidad extracontractual del Estado recién fue abandonado en 1933, cuando la Corte Suprema de Justicia de la Nación dictó sentencia en el caso «Tomás Devoto y Cía.». Tanto la doctrina como la jurisprudencia del referido Tribunal fundamentaron la obligación oficial de reparar los daños causas con su actividad lícita o ilícita, en las teorías sobre el deber de reparar los daños causados por los dependientes, la deficiente prestación de los servicios públicos y la expropiación. Existe actualmente un gran desarrollo de la responsabilidad estatal, aunque, debido a las leyes de emergencia y consolidación de deudas, una vez obtenida una sentencia de condena contra el Fisco, cabe hacer efectiva la solución del grave problema.

  15. Introducción a los fundamentos filosóficos del liberalismo

    OpenAIRE

    Francisco Vergara

    2000-01-01

    El liberalismo clásico, tema principal de la obra de Francisco Vergara1, trata de esta doctrina política, desarrollada entre 1730 y 1790 en Francia, el Reino Unido y, en cierta medida, en las colonias inglesas de América. El interés del autor no es sólo explicar cuáles son los límites de la libertad y el por qué de los límites que proponía esta doctrina sino, muy especialmente, cuáles son las diferencias fundamentales con el pensamiento dominante hoy en la economía mundial, denominado por alg...

  16. FUNDAMENTOS PARA EL ESTUDIO DE LAS CORRIENTES DE INVESTIGACIÓN EN CONTABILIDAD

    OpenAIRE

    VILLARREAL, José Luis; CÓRDOBA MARTÍNEZ, Jorge Xavier

    2017-01-01

    La contabilidad como disciplina de conocimiento se alimenta de teorías e investigaciones que permiten ampliar sus postulados y argumentos en la vía de su fundamentación que a la vez impacta en su ejercicio práctico. Así mismo, la evolución del conocimiento contable presenta avances desde la corriente principal y la denominada contabilidad emergente representada por la investigación contable crítica y la investigación contable interpretativa. De lo anterior se desprende la necesidad de reflexi...

  17. Fundamentos de una máquina asincrónica multipropósito

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    Marcos A de Armas Teyra

    2011-03-01

    Full Text Available El trabajo aborda el estudio teórico y experimental de una máquina asincrónica especial de rotor de jaula de ardilla condos devanados en el estator. Mediante la teoría, los ensayos de laboratorio y la experimentación, se establecen elmodelo matemático, el circuito equivalente y las pruebas para determinar sus parámetros. Este es un equipo competentey justificado en las condiciones de Cuba, con aplicación en diversas esferas de la vida económica y productiva de lanación, con un espacio en el mercado.  In this paper, a theoretical and experimental study of a special squirrel-cage asynchronous machine with two statorwindings is developed. The mathematical model, the equivalent circuit, and the tests necessary for determining theoperational parameters are established. It can be asserted that the multipurpose asynchronous machine is a competitiveequipment, with several applications and a clear space in the cuban market.

  18. LA RELIGIOSIDAD MAYA- ACHI’ GUATEMALTECA COMO FUNDAMENTO DE SU IDENTIDAD CULTURAL

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    David Caballero Mariscal

    2017-12-01

    Full Text Available En el contexto general de Guatemala, caracterizado por la diversidad étnica y cultural, y mayoritariamente indígena, los achi’es constituyen menos de uno por ciento de la población. Sin embargo, y a pesar de que han sufrido la imposición cultural de pueblos vecinos, de los españoles, y posteriormente, un atroz genocidio, continúan conservando parte de su patrimonio cultural intangible, manifestado en la lengua, las danzas, el Rabinal achi’,y diversas sus expresiones religiosas, que, sin duda, se constituyen en el garante de su identidad cultural. El presente artículo pretende llenar el vacío existente actualmente sobre la etnia achi’, ante la ausencia de estudios sobre ésta. De igual modo, trata de profundizar sobre los mecanismos adaptativos de sincretismo que se han desarrollado a nivel cultural y religioso como medio de supervivencia a través de nuevos modos de transculturación, que garantizan la pervivencia de la cultura y religiosidad maya tradicional en el contexto de la fe católica, vigente y mayoritaria entre los miembros de este pueblo maya.

  19. Spinoza: Los fundamentos filosóficos del realismo político

    OpenAIRE

    Francisco Vega Méndez

    2009-01-01

    This work defends the thesis that Spinoza's political thinking is in fact realist against the thought that it is utopist or chimerical imagination. It also sustains that Spinoza, with a line of thought immanent to this world, has provided the philosophical foundation to political realism that have been absent in the thought of twentieth century authors of this political current.

  20. Transuranics Laboratory, achievements and performance; Laboratorio de Transuranicos, logros y fundamento

    Energy Technology Data Exchange (ETDEWEB)

    Gasco, C.; Anton, M. P.

    2004-07-01

    The Marine and Aquatic Radioecology Group (MARG) was established in 1985 with the main scope of analysing the consequences of the Palomares accident in the adjacent Mediterranean ecosystem. From then on and up to now , this Group has extended its investigations to other European marine environments, such as the Spanish Mediterranean margin, the Artic and the Atlantic. The main research of long-lived radionuclides (plutonium, americium and Cs-137) determining the orography influence, riverine inputs and their geo-chemical associations. This group is currently accomplishing new challenges on the radioecology field such as the development of techniques for transuranics speciation to determine their geo-chemical association to the main sediment compounds. Natural and anthropogenic radionuclides distribution on salt-marsh areas affected by dry-wet periods is being studied as well as the possibilities of fusing crossed techniques for dating recent sediments (pollen, anthropogenic, ''210 Pb, etc). The Laboratory performance description, the procedures used, calculations, challenges and gaps are described in this report. (Author) 22 refs.

  1. Los fundamentos amazonicos en la antigua religion prehispanica. Los murcielagos en el simbolismo de los chavin

    OpenAIRE

    Wong Robles, Antonio Ruben

    2014-01-01

    El presente trabajo muestra la relación entre las representaciones más importantes de estilo de la cultura Chavín y la representación grafica del murciélago como representante simbólica de un grupo social de origen eminentemente selvático. This paper shows the relationship between the most important representations of Chavin style and the graphical representation of the bat as a token representative of a social group of wild and selvatic origin eminently

  2. Fundamentos filosóficos de la dignidad humana y su incidencia en los derechos humanos

    OpenAIRE

    Torres Bardales, Coloníbol

    2015-01-01

    El ser humano tiene dos vidas. Una física y otra humana. Ambas son diferentes pero están íntimamente relacionadas. La vida humana no es biológica, no es la persona de carne y huesos; no son los músculos ni la masa encefálica, ni los demás órganos que le dan existencia física. Su origen se encuentra en la organización de la sociedad, en las instituciones sociales, y entre ellas, la familia es clave fundamental. La dignidad humana es el epicentro de la constitución política del Estado, base fil...

  3. LA ECO­ POIESIS COMO FUNDAMENTO DE UNA PERSPECTIVA AMBIENTAL PARA LA ADMINISTRACIÓN

    Directory of Open Access Journals (Sweden)

    Arango Fernández Wilfer Ignacio

    2008-07-01

    Full Text Available La realidad no es tan simple como se quisiera. Es compleja de modo que no puede ser siempre comprendida bajo simples reglas. Por ello, las exploraciones de la ciencia han catalizado una profunda re­conceptualización del universo. Una nueva manera integral de ver, pensar y conocer el mundo ha sido introducida. La nueva perspectiva busca entender sistemas que cambian de manera s no propia s para una visión línea l. La s organizaciones, particular m ente las empresariales, están sujetas a los mismos principios de la nueva ciencia, y uno de los principales impactos en la aplicación de los conceptos de la complejidad yace en la forma como estas son percibidas. En el siglo 21, las empresas no serán por más tiempo administradas eficientemente por objetivos o perspectivas lineales y rígidas. Los estados de caos conducen a la creatividad, a la innovación y a la autoorganización ; desorden, disipación y cambio son la regla, no más la excepción. Este artículo propone el entendimiento de las organizaciones en términos de una percepción holística, confrontando las visiones tradicionales y explorando la relevancia del nuevo paradigma en el campo de relación entre organizaciones y medio ambiente. Se proporciona un panorama del significado del cambio de percepción, seguido por la manera en la cual las teorías (complejidad, eco­poiesis, estructuras disipativas, organizaciones vivas pueden ser aplicadas en el campo administrativo.

  4. Os Fundamentos do Conhecimento na Modernidade: o Método Científico em Popper

    Directory of Open Access Journals (Sweden)

    Alexcina Oliveira Cirne Vieira da Cunha

    2017-02-01

    Full Text Available O presente artigo tem como objetivo apresentar os postulados teóricos, em especial o conceito de falseacionismo, do racionalismo crítico de Popper. Inicia com suas críticas ao positivismo lógico, bem como a sua recusa de fornecer cientificidade aos princípios do historicismo e seu entendimento sobre a posição da metafísica na construção dos postulados científicos. Conclui com a crítica de Popper ao método indutivo e com reflexões sobre a importância das refutações e conjecturas na busca por um equilíbrio nas conclusões científicas, que não devem ser definitivas e dogmáticas.

  5. Princípios e fundamentos da pedagogia da alternância: alguns desdobramentos atuais

    OpenAIRE

    Mocelin, Nayara Massucatto

    2016-01-01

    A Pedagogia da Alternância (PA) é uma metodologia de ensino diferenciada, criada inicialmente para atender as necessidades que envolvem a população do campo. Por meio de seus instrumentos pedagógicos, distintos do ensino tradicional, procura, com autonomia, formar crianças e jovens a partir da articulação de tempos e espaços, além de envolver a família e comunidade no processo formativo e no desenvolvimento do meio. Por ter se consolidado como uma alternativa que gerou resultados positivos, a...

  6. Fundamentos de las cuentas por finalidad del gasto público

    Directory of Open Access Journals (Sweden)

    Henry Antonio Mendoza Tolosa

    2010-07-01

    Full Text Available El presente artículo constituye una revisión temática de los fundamentosteóricos y empíricos de la contabilidad por finalidad del gasto relacionados con la exploración del instrumental requerido para su implementación. En este sentido, se advierte que Colombia no dispone de metodología, ni de series estadísticas actualizadas del gasto por funciones desde 1999, y hasta entonces privilegió su elaboración a partir de las operaciones efectivas de caja como técnica de registro que rige aún buena parte de la operación del presupuesto. En tal sentido, el documento presenta el marco metodológico difundido a nivel internacional por la Organización de las Naciones Unidas (ONU y el Fondo Monetario Internacional (FMI para la construcción de las cuentas por funciones del Gobierno en contexto con los desarrollos de la literatura de frontera en este campo, provenientes principalmente de la Comunidad Económica Europea, las experiencias y los modelos que en este frente han adoptado diferentes países en el mundo, el marco legal e institucional vigente en Colombia como soporte normativo para su elaboración, y los principales elementos de reflexión que surgen del diagnóstico de la organización institucional, metodológica y de disponibilidad de información apropiada para su implementación en el país.

  7. Los nuevos derechos sociales: El derecho al cuidado como fundamento del pacto constitucional

    Directory of Open Access Journals (Sweden)

    Ana Marrades

    2016-12-01

    Full Text Available Resumen Nos encontramos ante un momento histórico y político que sugiere una revisión constitucional, con necesidades específicas y diferentes a las de 1978. Existen nuevas demandas que exigen que se revise el pacto constitucional. Algunas afectan directamente al catálogo de derechos, especialmente a los llamados derechos sociales, y se refieren por un lado, a la necesidad de otorgar a los derechos sociales ya reconocidos la consideración de fundamentales con todo lo que ello conlleva; y por otro, a la necesidad de crear nuevos derechos. El previsible aumento de personas necesitadas de cuidados, la escasez de servicios públicos para su asistencia, el tipo de cuidado informal prestado casi exclusivamente por mujeres que tienen que afrontar problemas y dilemas personales que afectan al libre desarrollo de la personalidad y también al derecho a la igualdad, pero sobre todo, la falta de una ética de la solidaridad y de la responsabilidad extendida socialmente exigen el reconocimiento de un derecho al cuidado. Por ello, entendemos que este análisis debe ser realizado desde la perspectiva de género, entendida como una categoría de análisis abierta que apuesta por el ejercicio de una lectura crítica de la realidad para transformar la situación de mujeres y hombres en la sociedad en aras de la igualdad real que postula nuestra Constitución y partiendo de la función transformadora del Derecho Constitucional. La ética del cuidado, como una forma de aproximarse a los problemas morales «típicamente femenina», ha servido para señalar la importancia del cuidado como prescripción ética básica; y por tanto esta ética debería guiar la nueva configuración del catálogo de derechos para una futura revisión de la Constitución. Los derechos del cuidado a las personas y que por tanto constituyen necesidades humanas básicas para una vida digna, se formulan en un contexto de cambio que exige una intervención urgente del Derecho para reconocerlos y aplicarlos. La configuración de un derecho al cuidado podría tener una doble vertiente: la de ser cuidado, obviamente, pero también la de cuidar, lo que implicaría por ejemplo suspender la actividad laboral o disfrutar de unas condiciones especiales temporalmente en tanto que la necesidad perdure, lo que permitiría una implicación más igualitaria de los hombres en el cuidado. El cuidado ha sido tradicionalmente una función de las mujeres, ellas se han ocupado del cuidado de menores, enfermos y personas dependientes; sin embargo esta función tan encomiable y necesaria para facilitar las condiciones de una vida digna, las ha colocado en una situación de desventaja dificultándoles su participación en la esfera pública. La solución posible es la asunción por parte de toda la sociedad de que la esfera privada y en definitiva, las tareas de cuidado han de ser compartidas entre hombres y mujeres; y lo más importante: que esa reflexión debe pasar a las agendas políticas influyendo en la legislación y en las políticas públicas. Abstract We are faced with a historical and political moment which suggests a constitutional revision, with specific and different needs from the 1978 needs. There are new needs that require to review the constitutional pact, some directly affect the catalogue of rights, especially to the so-called social rights, involving on the one hand, the need to grant social rights already recognized the consideration of basic with everything that that entails; and secondly, the need to create new rights. The foreseeable increase of people in need of care, the shortage of utilities for their assistance, the kind of informal care provided almost exclusively by women who are faced with problems and personal dilemmas that affect the free development of the personality and the right to equality, but above all, the lack of an ethic of solidarity and the responsibility socially extended require recognition of a right to care. Therefore, we understand that this analysis should be done from the perspective of gender, as a category of analysis open committed to the exercise of a critical reading of reality to transform the situation of women and men in society for the sake of real equality postulated in our Constitution and on the basis of the transformative role of the constitutional law. The ethics of care, as a way of approaching the moral problems «typically feminine», has served to emphasize the importance of care as basic ethical prescription; and therefore this ethics should guide the new configuration of the catalogue of rights for a future revision of the Constitution. The rights of care and which therefore constitute basic human needs to a dignified life, formulated in a context of change, require urgent intervention of the law to recognize them and apply them. The configuration of a right to care could have a twofold purpose: not only the right to be cared for, but also, the right to care for, implying for example to suspend work or enjoy special conditions temporarily while the need persists, which would allow a more equal involvement of men in care. Care has traditionally been a function of women, they have dealt with the care of children, sick and dependent persons; however this function so commendable and necessary to facilitate the conditions for a dignified life, has placed them at a disadvantage, making it difficult for them their participation in the public sphere. The possible solution is the assumption by the whole society that the sphere private and ultimately care tasks have to be shared between men and women; and most importantly: this reflection must have a political influence in legislation and public policies.

  8. Clínica da Atividade: conceitos e fundamentos teóricos

    Directory of Open Access Journals (Sweden)

    Francisco Pablo Huascar Aragão Pinheiro

    2016-01-01

    Full Text Available La clínica de la actividad surgió en la década de 1990 como una perspectiva de análisis e intervención en el trabajo. Dada la creciente difusión de esta propuesta en Brasil, tenemos la intención de presentar algunos de sus conceptos fundamentales, esto es, el oficio y la actividad, teniendo en cuenta su diálogo con la teoría histórico-cultural de Vygotsky y la lingüística de Bakhtin. Se destacan las interpretaciones de la laguna entre aquello que la organización “determina” y aquello que el trabajador “realmente hace”, a partir de un contrapunto con las perspectivas de la psicodinámica del trabajo y de la ergonomía. Para la clínica de la actividad es necesaria una solución dialéctica a esta laguna, proponiéndose la superación de la dicotomía entre actividad y subjetividad. Se discute la noción de oficio, destacándose sus cuatro dimensiones: personal, interpersonal, transpersonal e impersonal. Finalmente, se discute el concepto de actividad real, que incluye la actividad realizada y lo real de la actividad.

  9. Fundamentos filosóficos de la Psicología actual

    OpenAIRE

    Osorio, Alfonso

    2009-01-01

    El presente artículo analiza algunos presupuestos filosóficos (especialmente antropológicos) que subyacen a la Psico - logía actual, y que pueden afectar al ámbito educativo. Se muestra cómo, aunque la Psicología empírica se ha fundado separándose de la Filosofía, en el fondo se ha separado de algunas doctrinas filosóficas, asociándose a otras. A menudo, en la literatura psicológica, se descubre que se asumen algunos postulados filosóficos como el naturalismo, el dualismo cartesiano (con la c...

  10. Fundamentos de los códigos de ética de los colegios profesionales

    Directory of Open Access Journals (Sweden)

    Cristina Castillo Briceño

    2010-01-01

    Full Text Available El artículo es el resultado del análisis documental de los diversos códigos que rigen el desempeño profesional en Costa Rica y que se plasman en el quehacer de los colegios profesionales. El texto nace a partir de la experiencia docente en el aula universitaria al reflexionar sobre el adecuado desempeño profesional y más allá de las competencias técnicas propias de cada profesión.

  11. Frentes de ondas (wavefronts e limites da visão humana Parte 1: fundamentos

    Directory of Open Access Journals (Sweden)

    Jankov Mirko

    2002-01-01

    Full Text Available A luz se propaga uniformemente a partir de um ponto luminoso na mesma velocidade em todas as direções. Sua posição em cada determinado momento é uma esfera formada juntando-se todos os pontos em uma mesma fase e tendo como centro a sua própria fonte. Tais superfícies esféricas imaginárias chamam-se frentes de luz ou frentes de ondas. Há três fatores limitadores de detalhes mais finos para o olho humano: óptico (por causa da dispersão, difração, aberração cromática e aberração monocrom��tica, retínico e neural (limitação máxima de acuidade visual de aproximadamente 2,0 ou 20/10.Um sistema de equações matemáticas, polinômios de Zernike, pode definir superfícies geométricas para descrever aberrações ópticas monocromáticas, tanto as de baixa ordem ('prisma', 'esfera' e 'astigmatismo', quanto às de alta ordem ('coma', 'aberração esférica' e outros. Medida das aberrações ópticas nos dá informação sobre o desempenho total de todos os elementos ópticos do olho em conjunto. Dois sistemas descritos aqui, o aberrômetro baseado no princípio de Tscherning e o originado do sensor Hartmann-Shack, têm a mesma lógica: comparar a posição atual das frentes de onda com a ideal, calcular matematicamente qual é a superfície geométrica que descreve essa discrepância e representá-la em termos de polinômios de Zernike. A topografia corneana computadorizada também pode, com "software" adequado, descrever as frentes de ondas definidas por irregularidades corneanas com polinômios de Zernike, porém tal caracterização representa somente a superfície anterior da córnea. Em conclusão, a tecnologia de frentes de ondas oferece nova maneira de quantificar e classificar os erros de imagem óptica do olho humano. O próximo artigo abordará as peculiaridades da análise de frentes de ondas, bem como algumas aplicações clínicas e cirúrgicas no dia-a-dia da prática oftalmológica.

  12. Os fundamentos transcendentais da daseinsanalyse psiquiátrica de Ludwig Binswanger

    Directory of Open Access Journals (Sweden)

    Rodrigo Alvarenga

    Full Text Available Ludwig Binswanger compreendeu que era necessário reestruturar o método de investigação e abordagem dos fenômenos psicóticos, pelo afastamento da ontologia cartesiana do sujeito e do objeto, o qual pressupunha o dualismo e o solipsismo da consciência, para fundar uma abordagem intersubjetiva da psiquiatria. O objetivo desta pesquisa é justamente examinar esse percurso fenomenológico da Daseinsanalyse psiquiátrica de Ludwig Binswanger, no que se refere ao cumprimento daquilo para o qual ela própria se propôs, por meio da assimilação da investigação transcendental no campo das psicoses.

  13. La guadua: fundamentos para el diseño de estructuras agropecuarias

    OpenAIRE

    Osorio Saraz, Jairo Alexander; González Castrillón, Eugenia; Cortés Marín, Elkin Alonso

    2010-01-01

    Resumen: la guadua (Guadua angustifolia Kunth), el bambú de América, ha influenciado el desarrollo de la cultura colombiana, principalmente en la Región Andina y de manera particular en el Eje cafetero, a través de su aprovechamiento en todo tipo de usos tales como vivienda, muebles, instrumentos musicales, conducción de agua, puentes, jaulas, y, en fin, en un sinnúmero de utensilios y espacios tan amplios como la necesidad y la imaginación lo han permitido. En los últimos años, la guadua ha ...

  14. Fundamentos em processamento de linguagem natural: uma proposta para extração de bigramas

    Directory of Open Access Journals (Sweden)

    Edson Marchetti da Silva

    2014-08-01

    Ë senso comum que o texto escrito é uma importante forma de registrar as informações e que atualmente grande parte desse conteúdo informacional está disponível em meio digital. Entretanto, de maneira geral, os computadores lidam com o texto como sendo uma cadeia de caracteres que não têm nenhum significado. A área de Processamento de Linguagem Natural (PLN vem se empenhando em extrair significados do texto. Nesse sentido este trabalho apresenta uma revisão desse tema e propõe um método automatizado que utiliza uma heurística determinística denominada Heudet que visa extrair bigramas do texto. A meta é extrair o significado do texto através de um conjunto de expressões multipalavras identificadas. Os resultados obtidos foram melhores se  comparados com aqueles que utilizam-se das técnicas de medidas de associação estatística obtidas pelo software Ngram Statistics Package (NSP.

  15. Fundamentos de la detención preventiva en el procedimiento penal colombiano

    Directory of Open Access Journals (Sweden)

    Leonardo Cruz Bolívar

    2012-12-01

    Full Text Available La contribución se ocupa de analizar en concreto los principios que rigen la privación preventiva de la libertad en el procedimiento penal, desde el punto de vista constitucional, legal y de instrumentos internacionales, buscando armonizar los criterios que utilizan los jueces de garantías al momento de resolver la solicitud del fiscal en esta materia. El principio de proporcionalidad constitucional, los elementos desarrollados legalmente y los pronunciamientos del sistema interamericano de derechos humanos dan base a las interpretaciones que se proponen en el artículo, buscando proteger la libertad, sin renunciar a las necesidades básicas de la justicia y la sociedad que requieren un proceso penal eficiente y que responda a la realidad nacional.

  16. La conducta social en el tráfico: Fundamentos para la intervención.

    OpenAIRE

    Alonso Plá, Francisco Manuel; Esteban Martínez, Cristina; Calatayud Miñana, Constanza; Pastor Soriano, Juan Carlos; Alamar Rocatí, Beatriz; Medina Sarmiento, José Eugenio

    2007-01-01

    En este libro nos hemos orientado hacia el estudio de lo “prosocial” frente a lo “antisocial”. Es decir hacia aquellas conductas que favorecen la ayuda entre las personas frente a aquellas que no son de ayuda, que llegan a atentar contra las mismas y por ende contra la sociedad en general. un ámbito de especial interés para nosotros será el del tráfico y la seguridad vial. La prosocialidad esté basada en una decisión interior que requiere, sin lugar a dudas, de un control personal dirigido...

  17. Emociones y conducción: Teoría y fundamentos

    OpenAIRE

    Alonso Plá, Francisco Manuel; Esteban Martínez, Cristina; Calatayud Miñana, Constanza; Alamar Rocatí, Beatriz; Egido Portela, Ángel

    2006-01-01

    Podemos afirmar que las emociones son importantes desde el punto de vista de la conducta, sobre todo en lo que tiene que ver con los procesos decisionales. Pero nuestra conducta, nuestras decisiones ¿son mayormente el producto de las emociones o de la razón? ¿Es bueno emocionarnos, es adaptativo?, ¿lo es siempre?, ¿realmente podemos decir que existen emociones positivas y negativas?, ¿en función de qué criterios? Suponiendo que las emociones pueden afectar a la conducción y suponiendo q...

  18. Conceptos y fundamentos para una crítica del ‘tiempo vulgar’ en Heidegger

    Directory of Open Access Journals (Sweden)

    Martin Simesen de Bielke

    2016-12-01

    Full Text Available Una crítica del concepto vulgar de tiempo busca explicitar los caracteres básicos de dicho concepto y fundamentalmente las aporías en el planteo. En relación a lo primero, en este artículo se pone énfasis en el carácter “originario” del concepto vulgar, es decir, su conexión con el “tiempo del mundo” y en el nexo de fundamentación que conecta ambos – tiempo vulgar y tiempo del mundo – con la temporalidad originaria del Dasein. En relación a lo segundo (las aporías, el artículo cuestiona los límites de una atribución del concepto vulgar de tiempo a Aristóteles; se discute asimismo la homologación de espacio y tiempo, por un lado, y la relación entre tiempo y presencia por otro, dos presupuestos de la representación tradicional (física y filosófica del tiempo como medida/parámetro de los cambios en general.

  19. Fundamentos constitucionales para la protección del conocimiento tradicional

    OpenAIRE

    Vallejo Trujillo, Florelia

    2013-01-01

    El presente documento trata de responder una de las preguntas vigentes en las actuales discusiones sobre la protección del conocimiento tradicional, consistente en cuál debe ser la justificación teórica para la protección de dicho conocimiento. En esta medida, el escrito contiene una propuesta de fundamentación teórica, haciendo énfasis en el papel del Estado Social de Derecho como garante y protector de derechos fundamentales, y en el test de razonabilidad como herramienta idónea que perm...

  20. Estimating Rate of Insulin Resistance in Patients with Preeclampsia Using HOMA-IR Index and Comparison with Nonpreeclampsia Pregnant Women

    OpenAIRE

    Abhari, Farideh Rezaei; Ghanbari Andarieh, Maryam; Farokhfar, Asadollah; Ahmady, Soleiman

    2014-01-01

    Women with preeclampsia, independent of obesity and glucose intolerance, exhibit insulin resistance during pregnancy. The purpose of the present study is to determine whether early diagnosis of insulin resistance during pregnancy can predict preeclampsia. Through a case-control study, 675 pregnant women were selected and their first trimester blood was taken. Their fasting blood glucose and insulin were also measured after diagnosis of preeclampsia by 20 weeks of pregnancy. Based on the exper...

  1. Evaluation of naturally occurring radioactivity and calculation of effective human dose at Homa Mount in Nyanza province

    International Nuclear Information System (INIS)

    Otwoma, D.O

    2008-01-01

    Report 39 of 1984 (ICRP) conceded that there are needs to subject some natural sources of radiation to control as applied for the artificial ones for the artificial ones. Recommends that, environmental surveys need to be done to determine levels of radiation form HBRA. Data obtained from such studies are used locally to establish necessity of controls, size opportunities and enrich the global data

  2. Pleiotropic effects of lipid genes on plasma glucose, HbA1c, and HOMA-IR levels

    NARCIS (Netherlands)

    Li, Naishi; van der Sijde, Marijke R; Bakker, Stephan J L; Dullaart, Robin P F; van der Harst, Pim; Gansevoort, Ron T; Elbers, Clara C; Wijmenga, Cisca; Snieder, Harold; Hofker, Marten H; Fu, Jingyuan

    Dyslipidemia is strongly associated with raised plasma glucose levels and insulin resistance (IR), and genome-wide association studies have identified 95 loci that explain a substantial proportion of the variance in blood lipids. However, the loci's effects on glucose-related traits are largely

  3. Birinci trimesterde homeostasis model assessment -insulin resistance (HOMA-IR) indeksi tayini ile gestasyonel diabetes mellitus'un prediksiyonu

    OpenAIRE

    GÜMÜŞ, Yeliz

    2012-01-01

    Gestasyonel diabetes mellitus gebelikle birlikte ortaya çıkan veya ilk olarak gebelikte tanısı konan karbonhidrat intoleransı olarak tanımlanmaktadır. Toplumlardaki ağırlık artışı ve obezite oranlarının giderek yükselmesine paralel olarak GDM prevalansı da artmaktadır. Makrozomi, omuz distosisi, doğum esnasında fiziksel yaralanma, hipoglisemi, hiperbilirubinemi, solunum problemleri ve çocukluk çağında obezite gibi fetal ve neonatal risklerin yanı sıra, preeklampsi, sezaryen ile doğum...

  4. Logoterapia: fundamentos, principios y aplicación una experiencia de evaluación del Logro Interior de Sentido

    OpenAIRE

    Noblejas de la Flor, María Ángeles

    1994-01-01

    Se realiza en esta tesis un compendio sistemático de la logoterapia de viktor e. Frankl, acompañado de una valoración de la aportación de esta corriente a la psicoterapia y a la educación. En la parte experimental se han baremado para España los dos tests logoterapeuticos mas difundidos: el test pil (americano) y el logo-test (germano). Los resultados se han comparado con los baremos obtenidos en otros países. Se ha analizado la estructura facotiral de los tests baremados, así como correlacio...

  5. El fundamento científico de la función de filtro del médico general

    Directory of Open Access Journals (Sweden)

    Juan Gérvas

    Full Text Available Los servicios sanitarios cuentan con niveles de atención, lo que optimiza los resultados. Los niveles tienen "filtros" que aumentan la prevalencia de enfermedad entre los pacientes que llegan a niveles sucesivamente altos. En este trabajo se justifica la existencia del filtro del médico general con respecto al especialista y al hospital por el aumento de la prevalencia de enfermedad en la población derivada de primaria a hospitalaria. Se utilizan ejemplos empíricos respecto al dolor abdominal, dolor precordial y hemorragia rectal. En este último ejemplo, la prevalencia del cáncer de recto y de sigma pasa del 0,1% en la población al 2% en la consulta del médico general (por efecto del filtro personal y familiar y al 36% en la consulta del especialista (por efecto del filtro del médico general. La selección aumenta el valor predictivo positivo de las pruebas diagnósticas que solicita el especialista, y evita el contacto innecesario con los especialistas a muchos pacientes con hemorragia rectal por causa benigna, que permanecen en su nivel (de la familia, o del médico general.

  6. Aproximación a los fundamentos neurológicos de la metáfora

    Directory of Open Access Journals (Sweden)

    Fajardo Uribe Luz Amparo

    2005-06-01

    Full Text Available El estudio del cerebro ha despertado múltiple interés en las últimas décadas, dada la importancia que éste tiene a la hora de determinar las diferentes funciones que el cuerpo humano puede desarrollar. Con respecto al lenguaje, los análisis han permitido, por una parte, descubrir las áreas del cerebro particularmente involucradas con cada una de las habilidades: escuchar, hablar, leer y escribir; y por otra, determinar el funcionamiento del cerebro cuando enfrenta los procesos de producción y comprensión especialmente referidos al lenguaje literal. En los últimos tiempos, se ha comenzado a explotar el campo de la comprensión y producción del lenguaje figurativo y se ha determinado, a partir de los efectos que producen algunas patologías, cómo el hemisferio derecho incide en la comprensión y producción metafórica.

  7. Posições subjetivistas e objetivistas de ciência: a hermenêutica como fundamento da pesquisa qualitativa

    Directory of Open Access Journals (Sweden)

    João Manoel Roratto

    2010-04-01

    Full Text Available Este trabalho discute aspectos relacionados à evolução recente da ciência, com ênfase no conflito entre posições objetivistas e subjetivistas, até chegar à importância da pesquisa qualitativa na construção do conhecimento científico na atualidade, com base nos variados campos de tradição e linhas de pensamento nas ciências sociais e nas formulações teóricas de Gadamer sobre hermenêutica. Nos estudos de Denzin e Lincoln, analisa-se a relevância da pesquisa qualitativa nos últimos tempos e sua forma metodológica diversificada e peculiar de representar as diferentes realidades que compõem o universo social, bem como as expectativas desse modelo de pesquisa a se afirmar como ciência. Em Gadamer, busca-se entender a construção do processo retórico e hermenêutico como método para compreender e explicar a realidade social, cujas bases ontológicas estão nas ideias originais de Platão sobre discurso e de Aristóteles sobre filosofia prática.

  8. Fundamentos, Orientaciones, Areas Basicas y Procedimientos para la Investigacion Educativa (Bases, Guidelines, Basic Areas, and Procedures for Educational Research).

    Science.gov (United States)

    Ministerio de Educacion Nacional, Bogota (Colombia). Instituto Colombiano de Pedagogia.

    This document establishes the bases, general guidelines, basic areas, and procedures for educational research conducted in Colombia. The philosophy underlying research objectives is explained. There is special interest in social research concerning the condition of man and of the social groups that will be the targets of education, and in research…

  9. Los fundamentos y el legado de la contestada independencia de Kosovo: entre derecho y política internacionales

    OpenAIRE

    Simone Florio

    2011-01-01

    La manera en que Kosovo está a punto de obtener la independencia fue acogida con opiniones antitéticas en la comunidad internacional, en particular con respecto al derecho internacional. Este artículo tiene como reto aclarar la trayectoria jurídica que ha llevado Kosovo camino a la estatalidad. Tras determinar que Kosovo no goza, prima facie, de un derecho positivo a la independencia, su estatalidad de facto se pone en contraste con unas cuantas doctrinas que podrían contribuir a soportarla, ...

  10. Fundamentos del diseño tipográfico para pantallas de visualización de datos

    OpenAIRE

    Romero Gómez, Beatriz

    2016-01-01

    Estado de arte sobre el diseño tipográfico para pantallas de visualización de datos. Estat d'art sobre el disseny tipogràfic per a pantalles de visualització de dades. Master thesis for the Computer Science program on Multimedia.

  11. El fundamento y el uso de las clasificaciones científicas: dinámicas desfasadas

    Directory of Open Access Journals (Sweden)

    María L. Christiansen Renaud

    2010-01-01

    Full Text Available Este artículo plantea de forma sucinta problemas epistemológicos ligados a las prácticas clasi!catorias de la psiquiatría y la psicología, al revisar de modo crítico algunas de las premisas del movimiento antipsiquiátrico en su ofensiva contra el modelo naturalista de la psicología médica. En el intento abordar el debate desatado entre realistas y constructivistas en torno a la noción de enfermedad mental y sus derivaciones taxonómicas se expone la tesis propuesta por el !lósofo e historiador Ian Hacking bajo la expresión de un bucle de retroalimentación entre los médicos (clasificadores, los pacientes (clasificados y los sistemas de conocimiento (marcos categoriales. Por último se proyectan las ideas analizadas hacia un enfoque dominante en el terreno de la psicología actual: la psicometría, con el propósito de explorar, en este caso particular, el rendimiento explicativo de las posturas epistemológicas presentadas. This paper sets out epistemological problems raised by psychological and psychiatric classificatory practices, and it examines critically some premises supported by antipsychiatric movement against the psychiatric naturalism. In order to tackle the heated debate about the Reality / Construction of mental disorders —and its taxonomical implications— the famous Ian Hacking´s thesis about the looping e#ect derived from classificatory practices is proposed and analyzed. Finally, the exposed ideas are applied to Psychometry, a prevalent tendency at the present psychology. The aim is to evaluate the explanatory fertility of the epistemological positions established in this paper.

  12. Fundamentos lingüísticos del lenguaje periodístico y jurídico-administrativo

    OpenAIRE

    Carlos Oliva Marañón; Universidad Rey Juan Carlos

    2011-01-01

    El lenguaje humano está en constante evolución y el léxico es su repertorio más mutable. El objetivo de esta investigación es el estudio del léxico de la Administración para una mejor comprensión por parte de los ciudadanos. Este lenguaje presenta una idiosincrasia definida, no sólo de léxico, gramática y estilo, sino también de teoría lingüística. Los lenguajes periodístico y jurídico-administrativo constituyen una sinergia entre la lengua global, la lengua general y el lenguaje de especiali...

  13. Las dietas cetogénicas: fundamentos y eficacia para la pérdida de peso

    OpenAIRE

    Pérez-Guisado, Joaquín

    2008-01-01

    El consenso internacional es que los carbohidratos son la base de la pirámide alimenticia de una dieta saludable, de tal forma que la mayoría de los especialistas de hoy en día piensan que la mejor forma de perder peso es mediante una reducción en el número total de calorías ingeridas diariamente, principalmente las que vienen en forma de grasa. No obstante, esta revisión intentará demostrar que las dietas cetogénicas son desde un punto de vista fisiológico, bioquímico y práctico, un camino m...

  14. Las dietas cetogénicas: fundamentos y eficacia para la pérdida de peso

    OpenAIRE

    Pérez-Guisado, Joaquín

    2008-01-01

    El consenso internacional es que los carbohidratos son la base de la pirámide alimenticia de una dieta saludable, de tal forma que la mayoría de los especialistas de hoy en día piensan que la mejor forma de perder peso es mediante una reducción en el número total de calorías ingeridas diariamente, principalmente las que vienen en forma de grasa. No obstante, esta revisión intentará demostrar que las dietas cetogénicas son desde un punto de vista fisiológico, bioquímico y ...

  15. Redes sociais no recrutamento de imigrantes : fundamentos teóricos de uma proposta de explicação

    Directory of Open Access Journals (Sweden)

    Filipa Pinho

    2015-07-01

    Full Text Available This paper reviews the origins of the concepts of networks and social capital in sociology and in explaining migration. It intends to promote the relational theoretical perspective for the plausible emergence of a strong articulation between social networks of immigrants and of potential migrants, with social capital mobilization, for recruiting labour in shortage when there are opportunities at the destination country. Social networks may exert the same function than governmental programs with recruitment goals.

  16. Abraham Flexner y el Flexnerismo. Fundamento Imperecedero de la Educación Médica Moderna.

    Directory of Open Access Journals (Sweden)

    José Felix Patiño Restrepo

    1998-12-01

    Full Text Available

    En pasadas publicaciones me he referido a la necesidad de revisar los planes de estudio y de reorientar la precaria condición de la educación médica colombiana, tan seriamente afectada, entre otros factores, por la crisis del sistema hospitalario público, sistema que ha sido el eje de la educación tanto de pregrado como de postgrado, y por las recientes disposiciones legales que han reformado los sistemas de salud y de seguridad social en Colombia (Patiño 1991,1992a,b,1993a,b,1998.

    Hace diez años Jiménez Arango se refería a los escenarios educativos en los servicios de salud y en los hospitales públicos, de tan mala calidad por su extrema pobreza y atraso tecnológico, que no constituían un ambiente favorable para una sólida formación en las ciencias clínicas. Hoy, en medio de la profunda crisis que afecta al sector hospitalario y al sector de la salud en general, la situación no ha mejorado y, por el contrario, aparece aún más deteriorada.

    En cuanto a los planes de estudios de las facultades de medicina, he planteado que un curriculum adecuado debe partir de la premisa de que el enorme volumen de conocimiento biomédico actual no puede ser transmitido en su totalidad al estudiante y que, forzosamente, se debe aceptar la imposibilidad de formar un médico que “sepa de todo”, mediante un curriculum único y rígido. Más bien deben identificarse los campos de acción que son previsibles en el ejercicio futuro de la medicina, y diseñar planes de estudio flexibles, diversificados y versátiles destinados a capacitar a los médicos para las diferentes áreas de la actividad profesional a través de programas que ofrezcan áreas de concentración o de “especialización” en el pregrado. Entre ellas, la principal sería la de la medicina familiar, que es la versión moderna de la medicina general (Patiño 1991, 1992a,b,1993ab.

    La moderna organización social y las nuevas modalidades de prestación de servicios de salud introducen cambios profundos en el ejercicio de la medicina y crean nuevos problemas como la ruptura de la relación médico-paciente, el deterioro de la imagen pública del médico, el surgimiento del paciente como cliente, usuario o consumidor y las complejas implicaciones de la medicina tecnológica (Hafferty & Franks 1994. De la medicina hipocrática hemos pasado a una medicina organizada y gerenciada, a una práctica médica de tipo corporativo, en la cual el imperativo hipocrático ha sido reemplazado por un mandato burocrático, y se perciben serias amenazas contra la preservación de la medicina como profesión y como ciencia (Patiño 1998.

    Al tiempo que la educación médica es un sistema pedagógico, la facultad de medicina es una comunidad moral y, como lo afirmó Abraham Flexner a comienzos del siglo, siendo una división universitaria es también una corporación de servicio público. Estoy convencido de que la misión de la educación médica moderna, ahora más que nunca, se define y se aclara con base en los preceptos establecidos por Flexner.

    Flexner murió en 1959, a la edad de 92 años, habiendo completado una admirable hoja de vida como educador y promotor de la excelencia académica (Bonner 1998...

  17. Fundamentos prácticos de seguridad en redes inalámbricas ieee 802.11

    OpenAIRE

    Sarmiento, Oscar P.; Guerrero, Fabio G.; Rey Argote, David

    2010-01-01

    Este artículo presenta una discusión tutorial de tres estándares de seguridad de uso común en las redes inalámbri-cas IEEE 802.11: WEP, WPA y WPA2. Se realiza un análisis detallado del algoritmo RC4 que soporta a WEP y se in-dican sus vulnerabilidades. También se revisan los aspectos y características técnicas más relevantes de los protoco-los de cifrado WPA y WPA2 con la finalidad de hacer un análisis comparativo de los tres estándares en términos de la seguridad que ellos proporcionan. Se h...

  18. Diagnóstico socioambiental como fundamento para una estrategia de educación ambiental en Colonet, Baja California

    Directory of Open Access Journals (Sweden)

    Rosa Hidemi Ortega Armenta

    2012-01-01

    Full Text Available Colonet, Baja California, es una comunidad rural localizada en una zona árida, donde existe la propuesta de construir un megaproyecto portuario. Ahí se realizó un diagnóstico socioambiental, con el fin de identificar la problemática actual del medio ambiente y posibles soluciones, a través del análisis de la percepción social y las amenazas ambientales. El desabasto de agua se percibe como el problema principal debido a factores sociales y políticos, y las prácticas agrícolas se identificaron como la amenaza ambiental primordial. Estos resultados demuestran la necesidad de mejorar la organización comunitaria, con base en mayor y mejor información. Se identificaron las soluciones y se diseñaron cuatro escenarios. Aquí se propone una estrategia de educación ambiental, que fomente la organización y participación informada en la comunidad, para lograr la tecnificación agrícola orgánica y la gestión integrada de recursos hídricos.

  19. Theoretical fundamentals for the new regulation of the electric power sector; Fundamentos teoricos de la nueva regulacion electrica

    Energy Technology Data Exchange (ETDEWEB)

    Perez Arriaga, J.I.

    1998-12-01

    Regulatory models for the electric power industry throughout the world are experiencing significative changes at a umprecedented pace. It is then justified to speak of a new regulation of the electric power sector, with features of its own. This paper presents the theoretical background for this new regulation, focusing on the identification characterization and analysis of the several activities comprised in electricity supply, as well as the most suitable regulatory approach for each one of them. (Author)

  20. The institutional foundations of energetic integration at the South America; Os fundamentos institucionais na integracao energetica da America do Sul

    Energy Technology Data Exchange (ETDEWEB)

    Suarez, Lizett Paola Lopez; Guerra, Sinclair Mallet-Guy [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Faculdade de Engenharia Mecanica. Dept. de Energia]. E-mails: lizlosu@fem.unicamp.br, sguerra@fem.unicamp.br; Udaeta, Miguel Edgar Morales [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia (IEE)]. E-mail: udaeta@pea.usp.br

    2006-07-01

    From the revision and analysis of the energy integration process in South America, the present article goals to show which are the institutional basis that endorse the process, once these entities act directly with questions related to the energy sector or to the wider economic integration where the energy integration is inserted. Thus, the Regional entities, that can be associations, organizations and commissions, like ALADI, ARPEL, CEPAL, CIER, OLADE and others are mentioned and analyzed. The analysis points out that these entities constitute the institutional basis for support the decision making of the region countries, considering the achieved studies, the promoted debates, the establishment of norms and information treatment. Finally, it is emphasized that these entities can not and should not have decide and execute, since are the governments (politic will) the responsible for the planning and coordination role for having the integration project effectively implemented. (author)

  1. EL PAPEL DE LOS MUNICIPIOS COLOMBIANOS EN LA PLANEACION Y GESTION DEL DESARROLLO LOCAL: SUS FUNDAMENTOS TEORICO-CONCEPTUALES

    Directory of Open Access Journals (Sweden)

    Oscar Hernan Muñoz

    2001-07-01

    Full Text Available A partir de la crisis de los paradigmas del desarrollo y el neoliberalismo se dio un cambio en el tratamiento del desarrollo, visto como “un desarrollo a escala humana”, que acepta lo global, lo regional y lo local. Este nuevo enfoque del Desarrollo Local Endógeno permite reforzar la capacidad de la localidad para buscar formas autónomas de Desarrollo económico, social, político, etc., con base en la utilización plena de sus recursos. Dentro de este contexto se identifican seis condiciones básicas, que permiten potenciar el Desarrollo Local Endógeno: existencia de un tejido humano dinámico; identidad social; existencia de centros sociales dinámicos; densidad y diversidad de redes de información; capacidad social para asimilar cambios y el grado de diversificación del mercado de trabajo. Al mismo tiempo, se presentan factores que pueden obstaculizar el desarrollo como: bajos niveles de formación del recurso humano; carencias en el acopio y procesamiento de información; escaso desarrollo de la planificación y de gestión pública y privada, entre otros. Para abordar el estudio del Desarrollo Local Endógeno es necesario analizar la dinámica interna y sus interrelaciones con otros espacios. A escala interna se analizan aspectos locales relacionados con los recursos materiales y humanos, el poder y la organización social local y las relaciones económicas. A escala externa, el análisis del Desarrollo Local abarca elementos relacionados con vías de acceso; control y manejo del transporte y aprovechamiento de productos y personas; capacidad de liderazgo político y económico; sistemas locales de información y políticas de apoyo al desarrollo social. Un factor básico de la planeación y gestión del Desarrollo Local es el relacionado con la construcción de procesos de comunicación entre los actores locales, públicos, privados y comunitarios. La nueva lógica de la planeación tiene como objetivo la estructuración de “formas de autopedagogía colectiva” que lleven a los agentes a desarrollar una conciencia colectiva de su territorio y de su porvenir. En Colombia, el ordenamiento constitucional y el enfoque del Desarrollo Local Endógeno, les confieren a los municipios un papel preponderante en la planeación y gestión del desarrollo local; es decir, que el municipio debe ser, por excelencia, el espacio propicio para la formulación y ejecución de una verdadera política social, que brinde respuestas oportunas y concretas a las necesidades y expectativas de la comunidad local. Dentro de este contexto, las administraciones locales deben articular de una manera clara y coherente todas las acciones dirigidas específicamente a la promoción del desarrollo social del municipio, concertando con las entidades privadas locales las políticas, programas e instrumentos de empleo.

  2. Los fundamentos y el legado de la contestada independencia de Kosovo: entre derecho y política internacionales

    Directory of Open Access Journals (Sweden)

    Simone Florio

    2011-06-01

    Full Text Available La manera en que Kosovo está a punto de obtener la independencia fue acogida con opiniones antitéticas en la comunidad internacional, en particular con respecto al derecho internacional. Este artículo tiene como reto aclarar la trayectoria jurídica que ha llevado Kosovo camino a la estatalidad. Tras determinar que Kosovo no goza, prima facie, de un derecho positivo a la independencia, su estatalidad de facto se pone en contraste con unas cuantas doctrinas que podrían contribuir a soportarla, eso es, la autodeterminación de los pueblos, la teoría de la secesión como remedio, y los llamados “poderes dispositivos internacionales” (international dispositive powers. El análisis halla que la independencia de Kosovo podría justificarse bajo una teoría del reconocimiento colectivo, posiblemente reforzada con argumentos de remedio. El artículo sigue investigando sobre la efectividad y la legitimidad de su estatus independiente (criterios de estatalidad, y finalmente se sostiene la idea de que este giro de acontecimientos en Kosovo mejor se explica con un razonamiento más genuinamente político. La validez de la independencia como solución en sí misma no es discutida; en cambio, basándose en el intero proceso, se debaten los efectos negativos de haber llegado a tal resultado por medio de una decisión unilateral.

  3. Physical foundations, use instructions and applications of the Powderspec program; Fundamentos fisicos, instrucciones de uso y aplicaciones del programa Powderspec

    Energy Technology Data Exchange (ETDEWEB)

    Beltran L, V. [ICN, UNAM, A.P. 70-543, 04510 Mexico D.F. (Mexico); Gonzalez T, L. [ININ, A.P. 18-1027, Mexico D.F. (Mexico)

    1991-09-15

    A simple FORTRAN program, called Powderspec, for simulating the second order powder patterns and the electron paramagnetic resonance (EPR) spectra of ions in an orthorhombic crystal field, or nuclear magnetic resonance (NMR) from a crystal with quadrupole interaction, is introduced. Powderspec can be used over the full range 0 to 1/3 of the orthorhombic field parameter {lambda} = E/D, or that of the equivalent asymmetry parameter , {eta}, 0 to 1, which is used in NMR work. This program is about 60 times faster than those based on the 'grid' or on the Monte Carlo methods. It also produces very smooth powder patterns and spectra capable of revealing fine spectral features. (Author)

  4. Fundamentos teóricos de la estrategia de internacionalización en plan de desarrollo 1994-1998

    Directory of Open Access Journals (Sweden)

    García Isaza José Guillermo

    1995-06-01

    Full Text Available Este trabajo examina los objetivos en el área de comercio exterior de El Salto Social y los elementos teóricos que fundamentan su selección de prioridades estratégicas. Identifica las fuentes directas e indirectas de la estrategia de internacionalización y revisa los desarrollos teóricos que, a juicio del autor, sustentan la concepción del Plan o tienen relevancia analítica para la formulación de esta estrategia y de algunos de sus elementos particulares.

  5. Las historias de ciudades en algunos arquitectos colombianos. Una aproximación a los fundamentos de la historia urbana

    Directory of Open Access Journals (Sweden)

    Félix Raúl Eduardo Martínez Cleves

    2015-02-01

    Full Text Available This article evaluates the historiography built especially from architecture after the Academia Colombiana de Historia (the Colombian Academy of History ceased its interest in gathering cities history at the end of the 1930s. To do this, a repertoire of authors constituted by some of the most important architects of the twentieth century will be used. They will consider not only the physical aspects of cities, but also their backgrounds. in this sense, this paper seeks to contribute to the understanding of the current urban history and, in a very partial way, to the urban and architectural history, although the latter correspond to another text for length reasons. It is also understood that the intellectual production in these areas is still dominated by architects or research centers in which professionals have a significant interference.

  6. Fundamentos para Asociados en Desarrollo Infantil quienes trabajan con Ninos Pequenos (Essentials for Child Development Associates Working with Young Children).

    Science.gov (United States)

    Phillips, Carol Brunson, Ed.

    A study guide for the Child Development Associate (CDA) Professional Preparation Program, this Spanish-language guidebook contains essential information on the basics of good professional practice for early childhood educators. It includes self-study activities, checklists, and resources for additional information. Unit 1 provides an overview of…

  7. Training in fundamentals of radiological coverage in Laguna Verde NPP; Entrenamiento de fundamentos de coberturas radiologicas en la CLV

    Energy Technology Data Exchange (ETDEWEB)

    Lara H, M. A., E-mail: marcolarah@gmail.com [Comision Federal de Electricidad, Central Nucleoelectrica Laguna Verde, Carretera Cardel-Nautla Km. 42.5, Alto Lucero, Veracruz (Mexico)

    2014-10-15

    In 2010, the Institute of Nuclear Power Operations (INPO) celebrates the Knowledge Transfer and Retention Workshop, an event where nuclear regulators and operators presented the strategies that various NPP to worldwide were implemented to mitigate the consequences of this generational change and take advantage of it, the trend in the presented works was the same: the generational change occurs in a faster way that the transfer of knowledge, the future was already here and many NPP had not been adequately prepared to train its nuclear technicians and engineers in the tasks demanded by the industry of them, so in addition to preparing these workers to forced marches was necessary to establish strategies to retain at more experienced staff in the industry. The Laguna Verde NPP has not been exempt to this process; the preparation of personnel squares to replace those that reaching retirement age in the Comision Federal de Electricidad (CFE) has become extensive in the last five years, sometimes leading to have personnel covering functions without an alternate to the next lower position, the cause? Not enough staff. In the specific case of radiation protection (Rp) the time required for obtaining the status of Rp technician according to the ANSI/ANS 3.1 standard is 2 years, one of the tasks that most occupies part of these two years is training in radiological coverage, this training requires a mix of knowledge and experience, recently one of the concepts used for training in Rp is the evaluation and management of the radiological risk, topic that is considered in this technical work. (Author)

  8. Fundamentos bioquímicos de la inmunotoxicología de los opiáceos

    Directory of Open Access Journals (Sweden)

    Guillermo Orlando Narváez Quintero

    2009-07-01

    Full Text Available Se ha descubierto que la morfina, anteriormente conocida como una sustancia de origen vegetal extraída de la amapola, es sintetizada también por el cuerpo humano y hace parte del sistema opioide endógeno. La morfina endógena está involucrada en la regulación negativa del sistema inmune, regresándolo a sus condiciones basales luego de haber sido activado. Las investigaciones experimentales preclínicas y clínicas han mostrado que la administración de morfina conduce a efectos inmunosupresores, inhibiendo la actividad de las células asesinas naturales, la proliferación linfocitaria y la capacidad fagocítica de los polimorfonucleares y monocitos. Adicionalmente esta sustancia altera el patrón de síntesis, secreción y actividad paracrina de citocinas, favoreciendo así la respuesta inmune mediada por anticuerpos (Th2-dependiente e inhibiendo la respuesta inmune mediada por células (Th1-dependiente. Estos efectos son suprimidos por la naloxona, un antagonista de los receptores m. Al parecer la morfina actúa a través de una nueva variante del receptor m de péptidos opioides denominado m3, presente en la superficie de las células inmunocíticas. Llama la atención la similitud entre los efectos inmunotóxicos generados en adictos al opio, VIH negativos, con aquellos observados en pacientes no drogadictos VIH positivos que progresan hacia sida.

  9. Consideraciones sobre los fundamentos psicopedagógicos de la educación para la salud en la adolescencia

    Directory of Open Access Journals (Sweden)

    Adriana Monserrath Monge Moreno

    2018-01-01

    Full Text Available La acción psicoeducativa dirigida a adolescentes en la prevención de conductas riesgosas debe lidiar con las barreras que impone la convulsa sociedad moderna. Las herramientas psicopedagógicas constituyen andamiajes o recursos mediadores de tipo psicológico y social que posibilitan a largo plazo la prevención y protección a la salud de los adolescentes y jóvenes en temáticas que son una preocupación para las instituciones de salud, para ello se utilizan diversos espacios que van desde los públicos, como la escuela o las universidades, y los grupales que llegan hasta las sesiones individuales de atención y seguimiento si fuera preciso. Este trabajo pretende reflexionar sobre los principales sustentos psicopedagógicos de la educación para la salud en la adolescencia.

  10. FUNDAMENTOS TEÓRICOS Y METODOLÓGICOS PARA EL MAPA DEL ARTE RUPESTRE CUBANO. COMENTARIOS GENERALES

    Directory of Open Access Journals (Sweden)

    Divaldo A. Gutiérrez Calvache

    2010-06-01

    Full Text Available ResumenSe revisa y adopta un concepto propio para la elaboración del Mapa del Arte Rupestre Cubano, entendido como instrumento para el conocimiento de este patrimonio arqueológico, y de los datos comprobados en nuestro archipiélago. Se realiza una introducción histórica sobre el nacimiento y evolución de los criterios cartográficos para el arte rupestre cubano y se describen modelos que ejemplifican las diferentes experiencias obtenidas en la construcción de las fases operativas, bases de datos y tipos de mapas realizados para la obtención definitiva de dicha herramienta cartográfica.AbstractIt revises and adopts a specific concept for Cuba's Rock Art Map, understood as a tool for knowledge of the archaeological heritage of the data recorded in our island. It performs a historical introduction about the birth and evolution of mapping criteria for the Cuban rock art and it describes some models who exemplify the different experiences in the construction and operation phases, databases and types of maps made for obtaining final Cuban rock art map.

  11. Resiliência organizacional e marketing social: uma avaliação de fundamentos e afinidades

    Directory of Open Access Journals (Sweden)

    Daniel kamlot

    Full Text Available Resumo O presente artigo relaciona os conceitos de resiliência organizacional com os de marketing social, buscando expor os pontos em comum entre tais áreas de estudo e identificando de que forma ambas se associam. Tendo como base a análise da literatura referente a ambos os temas, foi realizada uma avaliação das confluências existentes entre a resiliência e os atributos basilares do marketing social, a fim de identificar aspectos que articulassem tais domínios de conhecimento. A proposição aqui apresentada indica que a adaptação e a mudança - de comportamentos, modos de proceder e atitudes, entre outras - compõem o que aproxima o estudo da resiliência dos princípios subjacentes ao marketing social, sendo ambos vinculados pela necessidade de alterar comportamentos e pela adequação a certas situações inesperadas. No caso do marketing social, um foco na geração de bem-estar social seria observado, enquanto, no caso da resiliência organizacional, o foco das empresas estaria na necessidade inerente de mudar para não serem superadas em seu mercado de atuação, aproveitando oportunidades eventualmente surgidas a partir de uma situação de ruptura.

  12. EVAPORACIÓN OSMÓTICA: FUNDAMENTOS Y APLICACIONES EN LA CONCENTRACIÓN DE JUGOS DE FRUTA

    Directory of Open Access Journals (Sweden)

    ADRIANA PATRICIA PULIDO DÍAZ

    2016-12-01

    Full Text Available Osmotic evaporation is a modification of traditional processes using membranes; where the effect of a vapor pressure differential, produced by a highly concentrated solution of extraction, water is transferred as vapor through a membrane that acts as a hydrophobic body. This membrane technology is presented as a great alternative for processing exotic fruits, producing concentrates that can be used in the daily diet, being more comfortable to use, reducing transportation costs and increasing the shelf life. This process has many advantages compared to traditional operations, allowing operated at atmospheric pressure and low temperature, ideal for heat-sensitive products.

  13. CÉLULAS MADRE: FUNDAMENTOS Y REVISIÓN DE LA EXPERIENCIA CLÍNICA EN ENFERMEDADES HEPÁTICAS

    OpenAIRE

    Dra. Daniela Fluxá; Dr. Guillermo Silva

    2017-01-01

    En la actualidad, el trasplante hepático es el único tratamiento curativo para enfermedades como la cirrosis en etapas avanzadas y falla hepática fulminante. Sin embargo, la escasez de donantes, su alto costo y la morbimortalidad asociada son limitaciones importantes de este procedimiento. A causa de lo anterior surge la idea de utilizar células madre como terapia alternativa al trasplante hepático. Numerosos tipos de células madre exhiben potencial para desarrollarse en hepatocitos viables: ...

  14. Reinversión en sanidad: fundamentos, aclaraciones, experiencias y perspectivas Disinvestment in health: fundamentals, clarifications, experiences and perspectives

    Directory of Open Access Journals (Sweden)

    Carlos Campillo-Artero

    2013-04-01

    Full Text Available En estos tiempos de crisis económica aumenta mucho más la presión por reducir el gasto como medida aislada que por aplicar fórmulas para maximizar la eficiencia de los servicios sanitarios. Disponemos de información, métodos y experiencias para obtener mejores resultados en salud con los recursos disponibles. En varios países se han adoptado diversas medidas para hacerlo. Una de ellas es la reinversión (también conocida como desinversión. Al tratarse de una táctica necesaria, pero compleja, alergénica y a menudo confundida, en este artículo se aclara su significado, se enmarca en su debido contexto y se describen los métodos y criterios empleados para identificar y priorizar las tecnologías médicas candidatas a la reinversión. Incluido el caso de España, se revisan las experiencias en reinversión de Nueva Zelanda, Australia, Canadá, Reino Unido e Italia, los obstáculos que afrontan y sus perspectivas a medio plazo. El desconocimiento no debería eximir socialmente de su aplicación, estemos o no en crisis. La mejora de la eficiencia social es una obligación del Sistema Nacional de Salud.During the economic crisis, the pressure to reduce health services expenditure as an isolated measure is greater than measures intended to increase the efficiency of these services. Information, methods and experiences to improve health outcomes with limited resources are available and a number of countries have been applying measures to achieve this goal. One of these measures is disinvestment. Given that this tactic is necessary but also intricate, allergenic and confusing, this article tries to clarify its meaning, place it in its correct context, and describe the methods and criteria used to identify and prioritize candidate medical technologies for disinvestment. The experiences of Spain, New Zealand, Australia, Canada, the United Kingdom and Italy in this endeavor are reviewed, as well as the obstacles faced by these countries when disinvesting and their mid-term perspectives. Ignorance does not excuse its application, regardless of whether there is a crisis or not. Efforts to improve social efficiency are a permanent obligation of the national health system.

  15. Fundamentos teoricos de la creacion de un modelo de adquisicion corporativa internacional: Caso de las principales empresas de Nuevo Leon

    Directory of Open Access Journals (Sweden)

    Cabeza, L.

    2008-07-01

    Full Text Available The importance to propose a success Model in the international corporate acquisitions consists of offering to the important Mexican firms the factors that will allow having greater success with the international investments. In this research we selected four of the most important firms of Nuevo Leon that have important experience with international acquisitions and present them the questionnaire that was designed to validate the variables of the Model. In this paper we present the theories that give the theoretical foundations to the variables of the proposed Model that consist of 6 variables or key success factors that need to be considered for an international acquisitions, which are: Country Knowledge, Industry Knowledge, Customer relationship, Supplier relationship, Technology and Market.

  16. HABILIDADES GERENCIALES COMO FUNDAMENTO DE LA ESTRATEGIA COMPETITIVA EN LOS SECTORES DE ACTIVIDAD METALMECÁNICA VENEZOLANA

    Directory of Open Access Journals (Sweden)

    Juliana Ferrer

    2006-01-01

    Full Text Available La realidad de la empresa venezolana centra su atención de largo plazo en una gestión humana, que teniendo en cuenta su desempeño distintivo, sea capaz de impulsar el desarrollo de los sectores productivos donde está inmenrsa. Es por ello que el cúmulo de competencias generales se convierte en fuente de estrategia competitiva, impulsando la toma de decisiones y potenciando la diferenciación en el mercado. A partir de tal reflexión surge la motivación del presente artículo, cuyo objetivo es analizar las competencias distintivas como fuente de estrategia en la empresa metalmecánica Zuliana, que representa una de los ramales de mayor importancia dentro de los sectores de actividad económica venezolana. Sustentada en una investigación descriptiva, de campo, se procedió a realizar un muestreo estratificado por conglomerado, estimando Maracaibo, San Francisco, Cabimas y Lagunillas, de la Región Zuliana. Se concluye que un 72% de los líderes evidencian habilidades técnicas, demostrando problemas en habilidades humanas; se observaron elevados niveles de interacción (62%, pero poco compromiso y sentido de pertenencia con la organización (26%. Se sugieren cursos de acción, tendientes a buscar una formación continua del talento humano, incorporando habilidades para fortalecer la agrupación de valor en los procesos productivos, que sean capaces de generar la ventaja competitiva necesaria para el fortalecimiento de la pequeña y mediana empresa de la zona.

  17. Fundamentos lingüísticos del lenguaje periodístico y jurídico-administrativo

    Directory of Open Access Journals (Sweden)

    Carlos Oliva Marañón

    2011-06-01

    Full Text Available El lenguaje humano está en constante evolución y el léxico es su repertorio más mutable. El objetivo de esta investigación es el estudio del léxico de la Administración para una mejor comprensión por parte de los ciudadanos. Este lenguaje presenta una idiosincrasia definida, no sólo de léxico, gramática y estilo, sino también de teoría lingüística. Los lenguajes periodístico y jurídico-administrativo constituyen una sinergia entre la lengua global, la lengua general y el lenguaje de especialidad. Los lenguajes específicos son de carácter mixto, a medio camino entre los lenguajes artificiales y las lenguas naturales con peculiaridades propias de carácter semiótico. Se concluye, por un lado, que el lenguaje administrativo es una realidad de percepción pasiva, ajena al circuito verbal de la comunicación que se da en la lengua común; y, por otro, que el lenguaje de la Administración es un código elaborado y prefijado que el ciudadano ha de aprender, aunque pierda parcialmente el control verbal. 

  18. La enseñanza de la medicina en el siglo 21: Fundamentos y desafíos

    OpenAIRE

    Vicente Valdivieso Dávila

    2007-01-01

    Durante la segunda mitad del siglo 20 se produjeron enormes avances en las ciencias naturales y en su aplicación tecnológica a la medicina, lo que trajo consigo espectaculares progresos en el diagnóstico y tratamiento. Sin embargo, este proceso de tecnificación de la actividad clínica ha tenido también consecuencias perjudiciales para el ejercicio profesional de la medicina y, muy en especial, para su enseñanza: fraccionamiento en múltiples especialidades inconexas, deshumanización y aumento ...

  19. Microextração Líquido-Líquido Dispersiva (DLLME) fundamentos e aplicações

    OpenAIRE

    Martins, Manoel Leonardo; Primel, Ednei Gilberto; Caldas, Sergiane Souza; Prestes, Osmar Damian; Adaime, Martha Bohrer; Zanella, Renato

    2012-01-01

    Nos últimos anos, as técnicas clássicas de preparo de amostra para a determinação de compostos orgânicos em amostras ambientais e alimentos estão sendo substituídas por técnicas miniaturizadas que são caracterizadas pelo baixo custo, alta eficiência, reduzida quantidade de solvente, além da possibilidade de automação. Dentre essas técnicas, a Microextraçao Líquido-Líquido Dispersiva (DLLME) apresenta-se como uma interessante alternativa para o preparo de amostra e está baseada na partição dos...

  20. Fundamentos epistémicos complejos de la educación intercultural bilingüe

    OpenAIRE

    Saida Luisa Guerra Velásquez; Josefa Coromoto Guerra

    2017-01-01

    La Educación Intercultural Bilingüe (EIB) en Venezuela ha mantenido un rol asimilacionista e hispanizante de los indígenas, a consecuencia de la imposición de saberes de la cultura dominante, la modernidad, la colonialidad del saber y el poder. Esta investigación reflexiva, planteada desde la hermenéutica diatópica, tiene como objetivo fundamentar los epistemes de la EIB con la complejidad. Se plantea que el devenir de la EIB juega un papel preponderante para entender su condición actual, con...

  1. Periodismo inmersivo: Fundamentos para una forma periodística basada en la interfaz y la acción

    OpenAIRE

    Domínguez Martín, Eva Maria

    2013-01-01

    L'impacte de tecnologies com la realitat virtual juntament amb la influència narrativa dels videojocs han afavorit el que anomenem una retòrica immersiva, una forma de relatar amb recursos visuals i interactius per tal d’aconseguir un alt grau d'immersió de l'usuari. Entenem per periodisme immersiu una pràctica periodística emergent que aplica les tecnologies i recursos necessaris amb aquest objectiu. Per bé que el periodisme immersiu té la seva expressió màxima amb l'aplicació de la tecnolog...

  2. Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the genetics of lipid lowering drugs and diet network study

    Science.gov (United States)

    Known genetic susceptibility loci for type 2 diabetes (T2D) explain only a small proportion of heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation in diabetes-related risk factors, and this epigenetic variation across the genome can contribute to the missing ...

  3. Consecutive repetition of lordosis-kyphosis in silverside Atherina boyeri Risso, 1810 collected from a wild population in Homa Lagoon, Izmir, Turkey

    Directory of Open Access Journals (Sweden)

    Jawad Laith

    2017-06-01

    Full Text Available The incidence of severe consecutive repetition of lordosis-kyphosis involving three flexions was reported in a specimen of the atherinid fish Atherina boyeri Risso. The values for the angles lay between the lines passing through the sides of the vertebral column and enclosing the curvatures, and the depth of the curvatures of the angles was obtained. Also, the ratio of the vertebral column to the fish total length of deformed and normal specimens of this species was calculated. Possible causes for these anomalies are discussed.

  4. Size and shape of the associations of glucose, HbA, insulin and HOMA-IR with incident type 2 diabetes : the Hoorn Study

    NARCIS (Netherlands)

    Ruijgrok, Carolien; Dekker, Jacqueline M; Beulens, Joline W; Brouwer, Ingeborg A; Coupé, Veerle M H; Heymans, Martijn W; Sijtsma, Femke P C; Mela, David J; Zock, Peter L; Olthof, Margreet R; Alssema, Marjan

    AIMS/HYPOTHESIS: Glycaemic markers and fasting insulin are frequently measured outcomes of intervention studies. To extrapolate accurately the impact of interventions on the risk of diabetes incidence, we investigated the size and shape of the associations of fasting plasma glucose (FPG), 2 h

  5. Size and shape of the associations of glucose, HbA1c, insulin and HOMA-IR with incident type 2 diabetes : the Hoorn Study

    NARCIS (Netherlands)

    Ruijgrok, Carolien; Dekker, Jacqueline M.; Beulens, Joline W.; Brouwer, Ingeborg A.; Coupé, Veerle M.H.; Heymans, Martijn W.; Sijtsma, Femke P.C.; Mela, David J.; Zock, Peter L.; Olthof, Margreet R.; Alssema, Marjan

    Aims/hypothesis: Glycaemic markers and fasting insulin are frequently measured outcomes of intervention studies. To extrapolate accurately the impact of interventions on the risk of diabetes incidence, we investigated the size and shape of the associations of fasting plasma glucose (FPG), 2 h

  6. Size and shape of the associations of glucose, HbA1c, insulin and HOMA-IR with incident type 2 diabetes: the Hoorn Study

    NARCIS (Netherlands)

    Ruijgrok, Carolien; Dekker, Jacqueline M.; Beulens, Joline W.; Brouwer, Ingeborg A.; Coupé, Veerle M.H.; Heymans, Martijn W.; Sijtsma, Femke P.C.; Mela, David J.; Zock, Peter L.; Olthof, Margreet R.; Alssema, Marjan

    AIMS/HYPOTHESIS: Glycaemic markers and fasting insulin are frequently measured outcomes of intervention studies. To extrapolate accurately the impact of interventions on the risk of diabetes incidence, we investigated the size and shape of the associations of fasting plasma glucose (FPG), 2 h

  7. Dietary Vitamin C Intake Reduces the Risk of Type 2 Diabetes in Chinese Adults: HOMA-IR and T-AOC as Potential Mediators.

    Directory of Open Access Journals (Sweden)

    Chunling Zhou

    Full Text Available Despite growing interest in the protective role that dietary antioxidant vitamins may have in the development of type 2 diabetes (T2D, little epidemiological evidence is available in non-Western populations especially about the possible mediators underlying in this role. The present study aimed to investigate the association of vitamin C and vitamin E intakes with T2D risk in Chinese adults and examine the potential mediators. 178 incident T2D cases among 3483 participants in the Harbin People Health Study (HPHS, and 522 newly diagnosed T2D among 7595 participants in the Harbin Cohort Study on Diet, Nutrition and Chronic Non-communicable Diseases (HDNNCDS were studied. In the multivariable-adjusted logistics regression model, the relative risks (RRs were 1.00, 0.75, and 0.76 (Ptrend = 0.003 across tertiles of vitamin C intake in the HDNNCDS, and this association was validated in the HPHS with RRs of 1.00, 0.47, and 0.46 (Ptrend = 0.002. The RRs were 1.00, 0.72, and 0.76 (Ptrend = 0.039 when T2D diagnosed by haemoglobin A1c in the HDNNCDS. The mediation analysis discovered that insulin resistance (indicated by homeostasis model assessment and oxidative stress (indicated by plasma total antioxidative capacity partly mediated this association. But no association was evident between vitamin E intake and T2D. In conclusion, our research adds further support to the role of vitamin C intake in reducing the development of T2D in the broader population studied. The results also suggested that this association was partly mediated by inhibiting or ameliorating oxidative stress and insulin resistance.

  8. Techno-Economic, Sustainability & Environmental Impact Diagnosis (TESED) Framework

    DEFF Research Database (Denmark)

    Loureiro da Costa Lira Gargalo, Carina; Carvalho, Ana; Matos, Henrique A.

    2014-01-01

    that truly sustainable design alternatives can befound.This work proposes a framework,called ‘Techno-Economic Sustainability Environmental Impact Diagnosis’ (TESED) that allows users to assess chemical/biochemical processes in a product oriented analysis.TESED is asystematic and generic approach that can......Nowadays, companies are looking for new sustainable design alternatives that improve their original processes.To assesst he best designalternative, economic aspects have been the preferred indicators. However, environmental and social concerns should also be included in the decision process so...

  9. Síndrome metabólica em crianças obesas e fatores de risco para doenças cardiovasculares de acordo com a resistência à insulina (HOMA-IR Metabolic syndrome and risk factors for cardiovascular disease in obese children: the relationship with insulin resistance (HOMA-IR

    Directory of Open Access Journals (Sweden)

    Aparecido Pimentel Ferreira

    2007-02-01

    Full Text Available OBJETIVO: Verificar a prevalência da síndrome metabólica e identificar fatores de risco para desenvolvimento de doenças cardiovasculares de acordo com a resistência à insulina. MÉTODOS: Realizou-se um estudo transversal em 52 crianças obesas. A amostra foi randomizada após avaliação do índice de massa corporal [peso (kg/estatura (m²] de 1.550 escolares. A obesidade foi definida quando esse índice se encontrava acima do percentil 95 da classificação do Centers for Disease Control and Prevention. O sangue de jejum foi utilizado para mensurar a glicemia, lipoproteínas de alta densidade, triglicerídeos e insulina. A gordura corporal foi avaliada pela absortometria de raio X de dupla energia. A pressão arterial e a resistência à insulina foram mensuradas. A síndrome metabólica foi definida segundo o critério do National Cholesterol Education Program, com pontos de corte ajustados para a idade da amostra. RESULTADOS: A síndrome metabólica esteve presente em 17,3% das crianças avaliadas. A resistência à insulina diferiu significativamente entre o sexo feminino (3,8±2,2; IC95% 2,9-4,8 e o sexo masculino (2,6±1,3; IC95% 2,1-3,1; p = 0,016. Cerca de 44,2% da amostra apresentou pelo menos dois fatores de risco, e 15% apresentou hipertensão arterial. A hipertrigliceridemia foi encontrada em 50 e 70,8% dos meninos e meninas, respectivamente. Os níveis de lipoproteínas de alta densidade abaixo do desejável foram encontrados somente nas meninas. CONCLUSÕES: Crianças obesas apresentaram alta prevalência de síndrome metabólica. Apresentaram mais fatores de risco aquelas que obtiveram maiores níveis de resistência à insulina. Desta forma, são necessárias medidas intervencionistas com intuito de barrar o ganho de peso durante a infância.OBJECTIVE: To identify the prevalence of metabolic syndrome and risk factors for the development of cardiovascular diseases and to investigate their relationship with insulin resistance. METHODS: This was a cross-sectional study of 52 obese children. The sample was chosen at random after the body mass index [weight (kg/stature (m²] of 1,550 schoolchildren had been calculated. Children were defined as obese when their BMI was above the 95th percentile of the Centers for Disease Control and Prevention classification. Blood samples were taken after fasting and glycemia, high-density lipoproteins, triglycerides and insulin were all assayed. Body fat was evaluated using dual energy X-ray absorptiometry. Arterial blood pressure and insulin resistance were also measured. Metabolic syndrome was defined according to National Cholesterol Education Program criteria, with cutoff points adjusted for the age of the sample. RESULTS: Metabolic syndrome was detected in 17.3% of the children investigated. Insulin resistance was significantly different for females (3.8±2.2; 95%CI 2.9-4.8 and males (2.6±1.3; 95%CI 2.1-3.1; p = 0.016. Around 44.2% of the sample exhibited at least two risk factors, and 15% exhibited arterial hypertension. Hypertriglyceridemia was observed in 50 and 70.8% of boys and girls, respectively. Lower than desirable high-density lipoprotein levels were only observed among the girls. CONCLUSIONS: Obese children exhibited a high prevalence of metabolic syndrome. The children with greater insulin resistance exhibited more risk factors. In the light of these findings intervention measures are necessary in order to prevent excessive weight gain during childhood.

  10. Anatomía del craneoencéfalo del ovino (raza merina) y sus fundamentos topográficos para una estereotaxis aplicada

    OpenAIRE

    Rodríguez, I.; Vázquez, J.M.; Robina, A.; Agüera Carmona, Sergio

    1983-01-01

    Ten heads of ovins (Merino race) are put to radiologic observation before and after repletions controlled by means of contrast in theeric e phalic cavities, resulting essencial for the images which are obtained, the perfect paralelism between the radiography plate and the median and basicranial plane of the encephalon. Upon this material succinct radiologic study of the craniencephalon is carried out. The axis and fundamental plane are determined (basicranial as well as vertical and transvers...

  11. Por dentro da autoeficácia: um estudo sobre seus fundamentos teóricos, suas fontes e conceitos correlatos

    Directory of Open Access Journals (Sweden)

    Marizeth Barros

    2010-09-01

    Full Text Available

    Partindo do conceito de autoeficácia como a crença que o indivíduo tem sobre sua capacidade de realizar com sucesso determinada atividade, o texto discute o construto da autoeficácia, desenvolvido por Albert Bandura, psicólogo canadense, face à pertinência do mesmo para entendimento das escolhas e desempenho profissional individual, e sua relação com a eficácia organizacional. Faz uma breve apresentação sobre a autoeficácia, destacando sua inscrição teórica, suas principais fontes e fazendo uma oportuna diferenciação deste com conceitos correlatos. Assim, elucida conceitos, contribuindo no avanço das discussões existentes. Para tal fim, aborda: (i a teoria social cognitiva; (ii a autoeficácia e suas fontes; e (iii conceitos conexos como autoconceito, autoestima, lócus de controle, expectativa de resultado e resiliência.

     

  12. Desenvolvimento Histórico e Fundamentos Metodológicos da Neuropsicologia Cognitiva Historical Development and Methodological Foundations of Cognitive Neuropsychology

    Directory of Open Access Journals (Sweden)

    Christian Haag Kristensen

    2001-01-01

    Full Text Available A neuropsicologia cognitiva é apresentada em seu desenvolvimento histórico e principais mudanças metodológicas. Os debates ontológicos sobre as relações entre mente e cérebro na história da psicologia são apresentados. O surgimento da neuropsicologia é descrito como resultante dos estudos sobre as relações entre afasia e lesões cerebrais. A pesquisa sobre cognição, uma forte ênfase na psicologia nas últimas quatro décadas, é reconhecida como uma contribuição na compreensão das operações mentais humanas. Tais desenvolvimentos acabaram por fortalecer as relações entre cérebro e mente. As principais propostas metodológicas em neuropsicologia cognitiva são discutidas com especial ênfase nos seguintes aspectos: debates entre estudos de caso e estudos de grupo; dissociações entre tarefas cognitivas; e avanços e limitações das técnicas de neuroimagem. Finalmente, descreve-se o processo histórico de organização científica e profissional da área.The cognitive neuropsychology is presented in its historical development and main methodological changes. The ontological debates are distinguished on the relations between mind and brain in the history of psychology. The appearance of neuropsychology is described as a result of the studies concerning the relations between aphasia and cerebral injuries. The research in cognition, a strong movement in psychology in the last four decades, is recognized as a contribution to the understanding of human mental operations. Such developments strengthened the relations between brain and mind. The main methodological proposals in cognitive neuropsychology are discussed with special emphasis for the following aspects: debate between case and groups studies; dissociations between cognitive tasks; and advances and limitations of the neuroimaging techniques. Finally, the historical process of scientific and professional organization of the area is described.

  13. The bases and keys for the future of the social work and services / Fundamentos y claves para el futuro de de los servicios sociales y el trabajo social

    Directory of Open Access Journals (Sweden)

    Antonio Gutiérrez Resa

    2009-10-01

    Full Text Available The actual values emerging from the Social Services and the Social Work treat to make compatible the Public Services Field with those which the Market offers. However, without the State Guarantee which to look after universality and local proximity, so after the quality of the Social Services and Social Work, it is the Market which treat to resolve the management of the human being. In the future the bases and keys of the Social Services and Social Work have to require, at least, from the Beneficiaries listening and participation, the same way as relation contents.

  14. La Responsabilidad Patrimonial de la Administración Pública con Fundamento en la Declaración de Inconstitucionalidad de una Ley

    Directory of Open Access Journals (Sweden)

    Clemente Checa González

    2004-01-01

    Full Text Available En este artículo se trata un tema de capital importancia, si es posible, o no, llegar a declarar la responsabilidad patrimonial del Estado-legislador como consecuencia de leyes que hayan sido declaradas inconstitucionales, y, más en concreto, qué ocurre en el supuesto de que de la previa aplicación de tal ley se haya derivado el abono de una serie de ingresos a cargo de los ciudadanos. Se analiza al respecto, en este trabajo, la naturaleza de las sentencias del Tribunal Constitucional, diferenciando entre las que tienen carácter retrospectivo o prospectivo, y con relación a estas últimas se examina la doctrina aplicada por el Tribunal Supremo español de que en estos casos es procedente la declaración de indemnización a los afectados, toda vez que concurren plenamente los requisitos para decretar la responsabilidad patrimonial de los entes públicos.This article examines whether the Government is liable for property damage for the action of its Legislative Branch, when one of its acts is declared unconstitutional. Special attention is given to the case of acts under the provisions of which revenues are collected from the citizens prior to the declaration of unconstitutionality. The relevant retrospective and prospective decisions of the Spanish Constitutional Court are discussed. In the case of the latter type of decisions, we examine the doctrine of the Spanish Supreme Court that authorizes compensations to the aggrieved party, insofar as all requirements to declare the liability of government agencies for property damage are fully met.

  15. Agroenergy: a course on the fundamentals of energy use in rural areas; Agroenergia: um curso sobre fundamentos do uso da energia no meio rural

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Eliane Framil; Tiago Filho, Geraldo Lucio [Universidade Federal de Itajuba (UNIFEI), MG (Brazil). Centro Nacional de Referencia em Pequenos Aproveitamentos Hidroenergeticos. Programa de Pos-graduacao em Engenharia da Energia], e-mail: elianef@unifei.edu.br, e-mail: tiago@unifei.edu.br

    2004-07-01

    Nowadays, according to IBGE (Brazilian Geography and Statistical Institute), there are about 12 million of brazilian people without access to the electric power. Most of these people lives in rural and remote areas and, consequently, they are distant of the energy distribution lines. Most of time, due to the high cost of implantation, these lines become unviable. This scenery has as consequence the migration of the peasant to the city aiming the improvement of his life quality. This fact does not become reality always. In this case, it is essential that the peasant has the access to the information so that he remains in the field. In front of such argument arose the Agroenergia's Course, aiming give to the peasant some knowledge about alternative sources of energy. These sources can be found in the environment and can be used in the electricity generation, among others purposes. Thus, universalize the access to the energy and decentralize the generation constitute ways for the social equality. (author)

  16. Comunicación 2.0, visibilidad e interactividad: fundamentos de la imagen corporativa de las Universidades Públicas de Madrid en YouTube

    Directory of Open Access Journals (Sweden)

    Oliva Marañón, Carlos

    2012-12-01

    Full Text Available En español: En los últimos años, el marketing en la Educación Superior ha ido creciendo en interés no sólo por su valor económico y comercial, sino por su carácter estratégico y por la promoción, la formación y el fortalecimiento de la comunicación de la marca “Universidad”. La plataforma YouTube se ha posicionado como un medio audiovisual de referencia en la que el usuario decide qué contenidos quiere ver, dónde y cuándo. Los objetivos de esta investigación son analizar la Publicidad Institucional Audiovisual de las Universidades Públicas de la Comunidad de Madrid y verificar la idoneidad de YouTube como medio de comunicación de estas Instituciones. Oferta académica adaptada al Espacio Europeo de Educación Superior (EEES e instalaciones de vanguardia configuran las señas de identidad de estos centros. Los resultados confirman la consolidación de YouTube como canal audiovisual para la transmisión de los mensajes corporativos de estas Universidades a su público objetivo.In english: In recent years, marketing in Higher Education has been growing interest not only for its economic and commercial value but for its strategic and promotion, training and strengthening the brand communication "University". The platform YouTube has positioned itself as an audiovisual medium of reference in which the user decides what content you want to see, where and when. The objectives of this research are to analyze the audiovisual institutional advertising of the Public Universities of Madrid and verify the adequacy of YouTube as a communication from these Universities. Degrees adapted to the European Higher Education Area (EHEA and modern installations make up the identity of these Universities. The results confirm the consolidation of YouTube as a channel for transmitting audiovisual corporate messages of these Universities to their target audience.

  17. ÉTICA DE LA RESPONSABILIDAD, COMO FUNDAMENTO PARA FORTALECER LAS DIMENSIONES ÉTICO-COMPETITIVAS EN LA EMPRESA METALMECÁNICA ZULIANA

    Directory of Open Access Journals (Sweden)

    Juliana Ferrer

    2002-07-01

    Full Text Available En el artículo se aborda una aproximación a la ética de la responsabilidad, en un ámbito donde las dimensiones representadas por calidad y excelencia, confiabilidad, seguridad y confianza, evidencian cómo esta categoría permite fortalecer los cimientos en el manejo de factores competitivos de las organizaciones, representados por la empresa metalmecánica zuliana. Siendo una investigación descriptiva, de campo, para el levantamiento de la información se adoptó el muestreo aleatorio estratificado, conformando dos estratos: pequeña empresa - mediana inferior y mediana superior -grande. Del conjunto de resultados puede inferirse que existe una moderada presencia de la categoría responsabilidad, respecto a factores competitivos, evidenciada especialmente por el primer estrato, donde sólo se destaca el manejo de esta categoría, frente a factores de mercado y confiabilidad. En el segundo estrato se mejora la relación en el conjunto de rasgos plasmados en el manejo ético-competitivo, aspectos que podrían potenciar una convivencia futura e internalizar una nueva cultura, asumida frente al conjunto de agentes sociales. Surge una nueva perspectiva en el plano de este sector industrial, basado en concepciones prácticas que, a partir de la cultura organizacional, puedan ser innovadas, asumida bajo una responsabilidad convencida y de sus actores.

  18. Agroenergy: a course on the fundamentals of energy use in rural areas; Agroenergia: um curso sobre fundamentos do uso da energia no meio rural

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Eliane Framil; Tiago Filho, Geraldo Lucio [Universidade Federal de Itajuba (UNIFEI), MG (Brazil). Centro Nacional de Referencia em Pequenos Aproveitamentos Hidroenergeticos. Programa de Pos-graduacao em Engenharia da Energia], e-mail: elianef@unifei.edu.br, e-mail: tiago@unifei.edu.br

    2004-07-01

    Nowadays, according to IBGE (Brazilian Geography and Statistical Institute), there are about 12 million of brazilian people without access to the electric power. Most of these people lives in rural and remote areas and, consequently, they are distant of the energy distribution lines. Most of time, due to the high cost of implantation, these lines become unviable. This scenery has as consequence the migration of the peasant to the city aiming the improvement of his life quality. This fact does not become reality always. In this case, it is essential that the peasant has the access to the information so that he remains in the field. In front of such argument arose the Agroenergia's Course, aiming give to the peasant some knowledge about alternative sources of energy. These sources can be found in the environment and can be used in the electricity generation, among others purposes. Thus, universalize the access to the energy and decentralize the generation constitute ways for the social equality. (author)

  19. Fundamentos del uso clínico de la eritropoyetina como neuroprotector Foundations of the clinical use of erythropoietin as a neuroprotective agent

    Directory of Open Access Journals (Sweden)

    Alain Valdivia Acosta

    2008-08-01

    Full Text Available Hace aproximadamente una década, se reportaron por primera vez, las propiedades neuroprotectoras de la eritropoyetina en estudios preclínicos. Todavía no se ha podido esclarecer con firmeza el posible mecanismo de acción neuroprotector de esta hormona, pero existen varias hipótesis. La eritropoyetina ha mostrado buenos resultados en preclínica como agente neuroprotector y todavía queda mucho camino por recorrer para lograr una adecuada efectividad y seguridad en la clínica en este sentido. Se investiga para lograr una eritropoyetina con actividad neuroprotectora que carezca, o al menos tenga disminuida su actividad hematopoyética. Disminuir sus efectos adversos, lograr una significativa biodisponibilidad al sistema nervioso central, alargar el tiempo de vida media y con ello evitar una alta frecuencia de administración al paciente, es lo que principalmente se está buscando. En este trabajo se realizó una búsqueda sobre los mecanismos de acción neuroprotectora hasta ahora propuestos para la eritropoyetina y se detallaron importantes consideraciones a tomar en cuenta, que pudieran influir sobre su utilización en la clínica.The neuroprotective properties of erythropoietin were reported for the first time in preclinical studies approximately a decade ago. The possible mechanism of neuroprotective action of this hormone has not been cleared yet, but here are diverse hypotheses. Erythropoietin has showed good results in preclinic as a neuroprotective agent and there is still a long way to go to attain an adequate effectivity and safety in the clinic in this sense. Research is being carried out to obtain an erythropoietin with neuroprotective activity that lacks or at least has a diminished hematopoietic activity. To reduce its adverse effects, to achieve a significant bioavailability to the central nervous system, to prolong its mean life and to avoid this way a high frequency of administration to the patient, is our main objective. In this paper, it is made a search of the mechanisms of neuroprotective action proposed for erythropoietin so far, and important considerations that may influence on its use in the clinic are stressed.

  20. Fundamentos clínicos y bases fisioterapeúticas físicas de la camptocormia: a propósito de un caso

    OpenAIRE

    Rodríguez Gómez, Miguel Angel

    2015-01-01

    La camptocormia (CC) o síndrome de la columna doblada es una afectación con etiología muy heterogénea que en la mayoría de los casos está relacionada con la Enfermedad de Parkinson (EP) y, por tanto con la alteración del sistema extrapiramidal. Clínicamente se aprecia en el plano sagital y consiste en una flexión tóraco-lumbar de unos 45º que se manifiesta al mantener una bipedestación prolongada y durante la marcha pero que se reduce completamente en sedestación y en decúbito supino. Afecta ...

  1. Análise dos fundamentos teóricos associados à pesquisa contábil na área ambiental = Analysis of environmental accounting research theories

    Directory of Open Access Journals (Sweden)

    Luiz da Costa Laurencel

    2010-01-01

    Full Text Available O artigo apresenta os principais enfoques teóricos aplicáveis à Contabilidade Socioambiental,analisando seus aspectos positivos e limitações, particularizados à consolidação de uma teoriacontábil de cunho ambiental. Para isso, realiza-se uma revisão da bibliografia pertinente ao tema,buscando estabelecer uma taxonomia da literatura contábil desta natureza, e comentam-seoportunidades para o desenvolvimento de linhas de pesquisas alternativas ao mainstream. O estudodemonstra a existência de um pluralismo teórico aplicável ao campo socioambiental, concluindo quehá outros enfoques teóricos capazes de se contraporem às suposições do mainstream. Apesar de aortodoxia contábil estar fundamentada em paradigmas funcionalistas, existem opções alternativaspara explicar os fenômenos socioambientais dentro da Teoria da Contabilidade.This paper presents the major conceptual positions for Social and Environmental Accounting while analyzingtheir strengths and limitations with respect to the consolidation of social and environmental accountingtheory. In order to do this, a review of the relevant literature was carried out tht tried to establish a taxonomyof related accounting literature and comments regarding the opportunities for developing alternative lines ofresearch to the mainstream. The study shows that theoretical pluralism occurs in this field and concludesthat there are other theoretical approaches capable of challenging the existing mainstream assumptions.Although accounting orthodoxy is based upon functionalist paradigms, there are alternative options that maybe used to explain the social and environmental phenomena within accounting theory.

  2. Fundamentos para la clasificación de plantas en el Plan de Estudio D de las carreras pedagógicas

    OpenAIRE

    Isidro Eduardo Méndez Santos; Alejandro Hernández Peña; Julio Rifá Télle

    2012-01-01

    RESUMEN Se expone y fundamenta el sistema taxonómico a utilizar en la disciplina Botánica, correspondiente a las carreras de Biología – Geografía y Biología – Química, del Plan de Estudio D, que se imparte en las universidades de ciencias pedagógicas de la República de Cuba. Basis for classification of plants in the D Curriculum teaching careers ABSTRACT The taxonomic system to be used for the teaching of Botany in the Syllabus D, that is implemented in the pedagogical universitie...

  3. Satisfacción y calidad percibida de afiliados al Sistema de Protección Social en Salud de México. Fundamentos metodológicos

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    Pedro J Saturno-Hernández

    2016-12-01

    Full Text Available Objetivo. Describir el marco conceptual, metodología de implementación y análisis de la Encuesta de Satisfacción de Usuarios del Sistema de Protección Social en Salud de México. Material y métodos. Se analizan los elemen­tos metodológicos de los estudios de 2013, 2014 y 2015, incluyendo el instrumento utilizado, muestreo y diseño del estudio, modelo conceptual y características e indicadores del análisis. Resultados. La encuesta captura información sobre calidad percibida y satisfacción. El muestreo tiene representación nacional y estatal. Se construyen y describen indicadores simples y compuestos (índice de satisfacción y porcentaje de problemas de calidad reportados. El análisis se completa mediante diagramas de Pareto, correlación entre indicadores y asociación con la satisfacción mediante modelos multivariados. Conclusiones. La medición de satisfacción y calidad percibida es un proceso complejo pero necesario para cumplir con la normativa y para identificar estrategias de mejora. La encuesta descrita presenta diseño y análisis rigurosos enfocados en su utilidad para mejorar.

  4. Tratamiento cognitivo-conductual de la adicción a videojuegos de rol online: fundamentos de propuesta de tratamiento y estudio de caso

    Directory of Open Access Journals (Sweden)

    Clara Marco

    2014-01-01

    Full Text Available El propósito de este trabajo es presentar una propuesta de tratamiento cognitivo-conductual para la intervención en la adicción a video juegos. Se presenta el caso de un varón de 21 años con problemas con el uso de los videojuegos. Se expone el procedimiento en cada una de las fases de las que consta el tratamiento, así como los resultados de su eficacia en un estudio de caso. Después de trece semanas de intervención se aprecian importantes cambios en el nivel de dependencia. Los resultados muestran una disminución significativa del tiempo de uso del ordenador y de juego, así como una mejoría del funcionamiento personal y social del paciente.

  5. Los Fundamentos del Pensamiento y las Prácticas Administrativas. 1- EL ROMBO Y LAS CUATRO DIMENSIONES FILOSÓFICAS

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    Renée Bédard

    2003-12-01

    Full Text Available Durante mis estudios de doctorado, experimenté muy tempranamente la dificultad de encontrar una metodología apropiada que mepermitiera dar cuenta de las informaciones y delos datos empíricos recolectados durante losquince años que había ejercido la función de asesora   adjunta   a   la   alta   dirección   de   la Universidad Laval, experiencia que constituiríael material de base de mi tesis.

  6. Tarefas de Aprendizagem para Alunos Fracos do 1° Grau: Fundamentos Teóricos e Sugestões Práticas

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    Dair Aily Franco de Camargo

    2007-06-01

    Full Text Available O presente artigo pretende: a discutir, a nível teórico, dos aspectos sempre implícitos na aprendizagem - atividade fisica ou lógico-matemática do sujeito que busca conhecer e aspectos figurativos ou operativos no objetivo a ser conhecido. b organizar e sintetizar a partir dos referidos conceitos, uma proposta de ensino para os alunos "fracos", particularmente os das séries iniciais do 1° grau, com objetivo central de promover seus respctivos desenvolvimentos.

  7. Concepções de participação nas políticas educacionais: fundamentos sócio-históricos

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    Juciley Silva Evangelista Freire

    2016-01-01

    Full Text Available The text presents the participation conceptions that have been developing in institutionalized social practices of education present in studies published in Education & Society (E&S journal. The adopted theoretical references questions the relationship between individual and society in modernity proposed by liberal theories and the criticism to them carried out by Marx and Mészáros, informing the contradictions and challenges posed by participatory processes in contemporary world. Studies show the displacement of social and political participation idea, as effective control of decision-makers by the subjects of labor, to the participation idea as a "management technique" of public services.

  8. Los fundamentos económicos de la política de transporte europea: un análisis crítico

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    Ginés de Rus

    2005-11-01

    Full Text Available Este trabajo realiza una revisión crítica de los principios subyacentes a la política de transporte europea y estudia cómo se han aplicado dichos principios en los últimos años. El análisis se centra en tres ideas principales: la integración/desintegración vertical entre infraestructuras y servicios de transporte como mecanismo que favorece o dificulta la introducción de competencia en el sector, la utilización de los principios de tarificación eficiente para hacer frente a las consecuencias de las externalidades negativas del transporte y, finalmente, la necesidad de disponer de criterios adecuados para la selección de proyectos de inversión si se desea aprovechar al máximo las ventajas derivadas de los efectos de red generados por el funcionamiento eficiente del sistema de transporte.

  9. EL JUEGO Y EL RITO COMO FUNDAMENTOS DE LA ESTRUCTURA DRAMÁTICA EN TRES OBRAS DE EGON WOLFF: LOS INVASORES, FLORES DE PAPEL Y CICATRICES

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    Eduardo Thomas Dublé

    2005-04-01

    Full Text Available El tema del juego tiene un lugar importante en la obra de Egon Wolff. Sus muy diversos modos de actualización en la extensa dramaturgia de este autor pueden sintetizarse en dos, que aparecen a lo largo de su producción con distintos matices y combinaciones. Por una parte, fundamenta las convenciones rituales de la cotidianeidad de los personajes, con funciones de disimulo y protección ante la realidad social que éstos perciben hostil. En este caso, el juego constituye un recurso para neutralizar y manipular al otro en beneficio propio, mediante el enmascaramiento. Pero también lo lúdico aparece con las características libertarias y creativas que le son propias, presentándose como una opción autentificadoraInside the dramatic world of Egon Wolf, social playacting establishes itself as a major theme. Its multiple and diverse modes of representation in his extensive dramaturgy could be summarized in two, appearing with different mances and combination throughout his work. On the one hand, they become the fundament of the ritual conventions of the commonplace acts of the characters, with the function of dissembling and self protection in front of the social reality which is perceived as hostile. In this case, playacting is a resource intended to neutralize and manipulate the other for personal benefit through masking strategies; but also the ludic element appears with creative and libertarian characteristics that are the character’s own, as an option for authenticity

  10. Uma Necessária Limitação ao Atual Conceito de Discricionariedade Administrativa: Fundamentos da Teoria da Discricionariedade Mínima

    Directory of Open Access Journals (Sweden)

    Julio Cesar de Sá da Rocha

    2011-12-01

    Full Text Available This writing reflects the necessityto limit the administrative discretionarity.This article preaches the precepts of the MinimumDiscretionarity Theory. Also brings thenewest theory of separation of powers, framingthe politic judicialization as a necessaryprocess to the attainment of fundamental directs.So, this script concludes that, not beingadopted the more profitable decision, the Efficiencyand Legality Principles will be injured,even as the Fundamental Rights to Good Administration,having the Judiciary authorizationto control the emanated administrativeact. In conclusion, the article deals with theTheory of the Minimum Discretionarity in environmentallaw.O presente escrito realiza uma reflexão sobre a necessidade de limitação da discricionariedade administrativa, visto que não é aceitável a manutenção de ato administrativo que viole o princípio da eficiência e, dessa forma, o princípio da legalidade em sentido material. O artigo prega os preceitos da Teoria da Discricionariedade Mínima, segundo o qual apenas fugiria à apreciação do Judiciário os atos emanados em situações onde não é possível distinguir uma "melhor solução". Traz também a mais nova teoria de separação dos poderes, enquadrando a judicialização da política como processo necessário à consecução dos direitos fundamentais. Desse modo, o presente trabalho conclui que, não sendo adotada a decisão mais proveitosa, restariam feridos os Princípios da Eficiência e da Legalidade, estando o Judiciário autorizado a realizar o controle do ato administrativo emanado.

  11. El dibujo como dispositivo pedagógico. Fundamentos del dibujo en la enseñanza contemporánea de las artes plásticas

    OpenAIRE

    RODRIGUES ESTEVES, PHILIP JOSÉ

    2012-01-01

    La presente disertación incide sobre las prácticas pedagógicas del dibujo en el contexto de la educación artística y pretende comprender las condiciones que hoy las caracterizan. El trabajo intenta fijar estas condiciones en el ámbito de una problemática que no es solamente la de la enseñanza del dibujo, sino también, y sobre todo, la de su aprendizaje. Comprender el dibujo como dispositivo pedagógico y, en particular, la importancia de los ejercicios en el aprendizaje del dibujo, exige pensa...

  12. Comunicación 2.0, visibilidad e interactividad: fundamentos de la imagen corporativa de las Universidades Públicas de Madrid en YouTube

    OpenAIRE

    Oliva Marañón, Carlos

    2012-01-01

    En los últimos años, el marketing en la Educación Superior ha ido creciendo en interés no sólo por su valor económico y comercial, sino por su carácter estratégico y por la promoción, la formación y el fortalecimiento de la comunicación de la marca Universidad. La plataforma YouTube se ha posicionado como un medio audiovisual de referencia en la que el usuario decide qué contenidos quiere ver, dónde y cuándo. Los objetivos de esta investigación son analizar la Publicidad Institucional Audi...

  13. Fundamentos lingüísticos del lenguaje periodístico y jurídico-administrativo. Linguistic foundations of the Journalistic and Juridical-Administrative Language

    OpenAIRE

    Oliva Marañón, Carlos

    2012-01-01

    El lenguaje humano está en constante evolución y el léxico es su repertorio más mutable. El objetivo de este trabajo es el estudio del léxico de la Administración para una mejor comprensión por parte de los ciudadanos. Este lenguaje presenta una idiosincrasia definida, no sólo de léxico, gramática y estilo, sino también de teoría lingüística. Los lenguajes periodístico y jurídico-administrativo constituyen una sinergia entre la lengua global, la lengua general y el lenguaje de especialidad. L...

  14. ESTUDIO DE COHORTES EN ATENCIÓN PRIMARIA SOBRE LA EVOLUCIÓN DE SUJETOS CON PREDIABETES (PREDAPS. FUNDAMENTOS Y METODOLOGÍA

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    Rosario Serrano

    2013-01-01

    Full Text Available El estudio PREDAPS pretende determinar el riesgo de desarrollo de diabetes y aparición de complicaciones vasculares en sujetos con prediabetes e identificar los factores asociados. Se trata de un estudio observacional de seguimiento de una cohorte de 1.184 sujetos con prediabetes y otra cohorte de 838 sujetos sin alteraciones en el metabolismo de la glucosa. Los datos de la etapa basal se obtuvieron de pacientes que acudieron a centros de Atención Primaria en España a lo largo del año 2012. Los sujetos con prediabetes fueron clasificados en tres grupos: aquellos que sólo tenían alteradas las cifras de glucemia en ayunas -entre 100 y 125 mg/dl-, aquellos que sólo tenían alterado el nivel de HbA1c -entre 5,7 y 6,4%- y aquellos que tenían alterados ambos parámetros. La información sobre sus características sociodemográficas, antecedentes familiares y personales, estilos de vida y tratamiento farmacológico se obtuvo de la historia clínica y de la entrevista realizada en la consulta por el médico. Se realizó un examen físico para determinar peso, talla, perímetro de la cintura y presión arterial y se realizaron análisis de sangre y orina. El estudio PREDAPS puede contribuir a disminuir la incertidumbre en las estrategias individuales de prevención en los sujetos con prediabetes. El seguimiento anual durante cinco años de los participantes posibilitará conocer el riesgo de desarrollo de diabetes mellitus tipo 2 y el de complicaciones macro y microvasculares en los tres grupos de sujetos con prediabetes, así como averiguar los posibles factores asociados a esos riesgos.

  15. FASES ESTACIONÁRIAS DE LÍQUIDOS IÔNICOS EM CROMATOGRAFIA GASOSA: FUNDAMENTOS, AVANÇOS RECENTES E PERSPECTIVAS

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    Leandro W. Hantao

    2016-01-01

    Full Text Available Since their original discovery in 1914, ionic liquids (IL have been widely examined and explored in chemistry due to their unique physical and chemical properties. Ionic liquids are collectively known as organic salts and have melting points of 100 °C or under. The molten salts most employed in analytical chemistry, including gas chromatography (GC, consist of an organic cation paired with an organic or inorganic anion. This class of materials exhibits negligible vapor pressure and may have their properties (e.g.thermal stability and selectivity structurally tuned by imparting different moieties to the cation/anion. Currently, there are an estimated 1018possible combinations of IL. In this context, the prospection of highly selective IL-based stationary phases for gas-liquid chromatography has enabled high peak capacity and efficient separations of many critical pairs in complex samples. In this review, we present and discuss fundamental characteristics of ionic liquids and introduce important solvation models for gas-liquid systems. In addition, recent advances and applications of IL in conventional and multidimensional gas chromatography are outlined.

  16. Foundations and implementation of information media on energy, environment and development; Fundamentos e implementacao de midia informativa sobre energia, ambiente e desenvolvimento

    Energy Technology Data Exchange (ETDEWEB)

    Mattozo, Vania A. [Santa Catarina Univ., Florianopolis, SC (Brazil). Programa de Pos-graduacao em Engenharia de Producao. Area de Midia e Conhecimento]. E-mail: vania@ieb.ufsc.br; Camargo, C. Celso Brasil [Santa Catarina Univ., Florianopolis, SC (Brazil). Dept. de Engenharia Eletrica]. E-mail: celso@labplan.ufsc.br; Lage, Nilson Lemos [Santa Catarina Univ., Florianopolis, SC (Brazil). Dept. de Jornalismo]. E-mail: lage@floripa.com.br

    2002-07-01

    This paper discusses the relationship among energy, development and environment. This relationship is the ground for a scientific journalism, performed as a M.Sc. program, for scientific, technological and social questions involving those subjects in the sustainable development discussions.

  17. Tratamiento cognitivo-conductual de la adicción a videojuegos de rol online: fundamentos de propuesta de tratamiento y estudio de caso

    OpenAIRE

    Clara Marco; Mariano Chóliz

    2014-01-01

    El propósito de este trabajo es presentar una propuesta de tratamiento cognitivo-conductual para la intervención en la adicción a video juegos. Se presenta el caso de un varón de 21 años con problemas con el uso de los videojuegos. Se expone el procedimiento en cada una de las fases de las que consta el tratamiento, así como los resultados de su eficacia en un estudio de caso. Después de trece semanas de intervención se aprecian importantes cambios en el nivel de dependencia. Los resultados m...

  18. A ciência-ação: fundamentos filosóficos e relevância para a enfermagem

    Directory of Open Access Journals (Sweden)

    Bertha Cruz Enders

    2010-01-01

    Full Text Available La práctica de la enfermería involucra la enfermera en decisiones y acciones al enfrentar las situaciones cotidianas de la clinica. En esas ocasiones, la enfermera usa conocimiento cientifico, la experiencia anterior, conceptos y la intuición para percibir las situaciones y desempeñar las acciones. Esa acción constituye una fuente de conocimiento que puede ser obtenido por medio de metodologías que siguen el enfoque interpretativo. El objetivo de este trabajo es presentar analíticamente la filosofía de la Ciencia-Acción en su relación con la construcción del conocimiento de la enfermería. La Ciencia-Acción es discutida como una metodología nueva en las ciencias sociales y su filosofía es tratada en relación a la epistemología de la enfermería. Este abordaje es recomendado para la enfermería porque focaliza la reflexión y destaca la práctica como fuente del conocimiento. Se concluye que la Ciencia-Acción tiene potencial para el avance de la teoría de la enfermería y del conocimiento de la práctica.

  19. Género y trabajo emocional. Los fundamentos de la precariedad en el nivel inicial. Mar del Plata, Provincia de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Romina Denise Cutuli

    2017-01-01

    Full Text Available En este artículo se abordará la precariedad laboral desde una perspectiva de género en la educación de nivel inicial. La escasa presencia del Estado, tanto en su rol de proveedor como de organismo de control en la provisión de servicios de cuidado, mantiene al cuidado infantil -con mayor intensidad durante los primeros tres años de vida- a horcajadas entre la familiarización y la mercantilización. La educación inicial tiene, así, un fuerte componente privado, en gran medida informal y precario, no sólo por las relaciones de trabajo que lo sustentan, sino por sus condiciones institucionales y de infraestructura.Esta precariedad mantiene un vínculo tenso con las exigencias de calidad atribuibles a una labor profesional. Se propone en este sentido, que la generización de la docencia en el nivel inicial, y su consecuente asociación con el trabajo de cuidado no remunerado, actúan como factor descalificador del trabajo. A este discurso desvalorizador se añadirían las expectativas de abnegación asignadas al rol maternal, lo que permite, a la postre, sostener la tensión entre precariedad y calidad.

  20. Del caos a los sistemas: los fundamentos de ingeniería en la teoría de la organización, 1879-1932

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    Yehouda Shenhav

    1997-06-01

    Full Text Available El presente documento rastrea la génesis del paradigma de sistemas en el estudio de las organizaciones en los Estados Unidos remontándose a las prácticas de ingeniería del siglo XIX. Los análisis empíricos para el periodo 1879-1932 se basan en los datos primarios recogidos de las tres publicaciones periódicas en que por primera vez se codificó y cristalizó el estudio de las organizaciones: Engineering Magazine, American Machinist, y ASME Transactions. Se halló que la evolución del paradigma de sistemas fue un producto de por lo menos tres fuerzas que forman una gestalt interactuante: (1 los esfuerzos de los ingenieros mecánicos que buscaban legitimidad industrial y cuyo paradigma profesional se virtió dentro del campo organizacional; (2 el periodo progresista (1900-1917 Y su retórica sobre profesionalismo, igualdad, orden y progreso; y (3 la agitación laboral, la que se percibía como una amenaza al orden económico y social estable. El documento proporciona una interpretación cultural y política, más que una funcional y económica, al surgimiento del pensamiento administrativo y la evolución de la teoría de la organización.