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Sample records for assessment study pts

  1. Comparison report of RPV pressurised thermal shock - international comparative assessment study (PTS ICAS)

    International Nuclear Information System (INIS)

    A summary of the recently completed International Comparative Assessment Study of Pressurized- Thermal-Shock in Reactor Pressure Vessels (RPV PTS ICAS) is presented here to record the results in actual and comparative fashions. The ICAS Project brought together an international group of experts from research, utility and regulatory organizations to perform a comparative evaluation of analysis methodologies employed in the assessment of RPV integrity under PTS loading conditions. The Project was sponsored jointly by Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS), Koeln, Germany, and Oak Ridge National Laboratory (ORNL), USA, with assistance from the Organization for Economic Co-operation and Development (OECD)/Nuclear Energy Agency (NEA)/Committee on the Safety of Nuclear Installations (CSNI)/Principal Working Group (PWG) No. 3 (Integrity of Components and Structures). The ICAS Project grew out of a strong interest expressed by participants in the previous FALSIRE II Project to proceed with further evaluations of analysis methods used in RPV integrity assessment. A Launch Meeting for the ICAS Project was held at GRS-Koeln, during June 1996, where an emphasis was placed on identifying the different approaches to RPV integrity assessment being employed within the international nuclear technology community. Also a Problem Statement was drafted that defined a Western type four-loop RPV with cladding on the inner surface. Also, a detailed task matrix was defined that included a set of transient thermal-mechanical loading conditions postulated to result from loss-of-coolant accidents. The primary focus of the analyses was on the behaviour of relatively shallow cracks under these conditions. The assessment activities based on the Problem Statement were divided under three tasks: deterministic fracture mechanics (DFM), probabilistic fracture mechanics (PFM) and thermal-hydraulic mixing (THM). An Intermediate Workshop was held at OECD/NEA-Paris during June 1997, to

  2. Overcooling transient selection and thermal hydraulic analyses of the Loviisa PTS assessments

    International Nuclear Information System (INIS)

    This paper describes transients selection and thermal hydraulic analyses of various PTS assessment studies performed for the pressure vessels of the Loviisa WWER-reactors. Deterministic analyses have been performed in various stages of the PTS studies and they have always made the formal basis for design and licensing of the reactor pressure vessel. The integrated, probabilistic PTS study was carried out to give an overview of the severity of all different PTS sequences, and give a quantitative estimate of the importance of the PTS issues in relation to the overall safety of the plant. Later, the sequences including external flooding of the pressure vessels were added to the PTS assessment. Thermal recovery annealing of the Loviisa 1 reactor pressure vessel took place during refuelling outage in 1996. (author). 10 refs, 4 figs, 3 tabs

  3. TRAC analysis and support of Oconee-1 PTS studies

    International Nuclear Information System (INIS)

    This paper describes the overall pressurized thermal shock (PTS) program at Los Alamos with emphasis on TRAC-PF1 calculations of severe overcooling transients for the Oconee-1 pressurized water reactor (PWR). A summary of results for several calculations are presented for the Oconee-1 PWR along with detailed discussions of two of the most severe overcooling transients predicted [main steam-line break and turbine-bypass valve (TBV) failures]. The calculations performed were plant specific in that details of both the primary and secondary sides were modeled in addition to a detailed model of the plant Integrated Control System (ICS). For the Oconee-1 main steam-line break transient, a minimum downcomer fluid temperature of approx. 405 K was predicted. For the TBV transient involving the failure of one bank of TBVs to close after initially opening following reactor and turbine trips, an extrapolated downcomer fluid temperature of approx. 365 K was estimated. The latter temperature is at the nil-ductility temperature (NDT) limit (approx. 365 K) for Oconee-1

  4. Transferability of results of PTS experiments to the integrity assessment of reactor pressure vessels

    International Nuclear Information System (INIS)

    The integrity assessment of the reactor pressure vessel (RPV) is based on the fracture mechanics concept as provided in the code. However this concept covers only the linear-elastic fracture mechanics regime on the basis of the reference temperature RTNDT as derived from charpy impact and drop-weight test. The conservatism of this concept was demonstrated for a variety of different materials covering optimized and lower bound material states with regard to unirradiated and irradiated conditions. For the elastic-plastic regime, methodologies have been developed to describe ductile crack initiation and stable crack growth. The transferability of both, the linear-elastic and elastic-plastic fracture mechanics concept was investigated with the help of large scale specimens focusing on complex loading situations as they result from postulated thermal shock events for the RPV. A series of pressurized thermal shock (PTS) experiments were performed in which the applicability of the fracture mechanics parameters derived from small scale specimen testing could be demonstrated. This includes brittle (static and dynamic) crack initiation and crack arrest in the low charpy energy regime as well as stable crack initiation, stable crack growth and crack arrest in the upper shelf toughness regime. The paper provides the basic material data, the load paths, representative for large complex components as well as experimental and theoretical results of PTS experiments. From these data it can be concluded that the available fracture mechanics concepts can be used to describe the component behavior under transient loading conditions. (author). 26 refs, 12 figs, 1 tab

  5. Mechanism of phosphoryl transfer and protein-protein interaction in the PTS system-an NMR study

    International Nuclear Information System (INIS)

    HPr and Enzyme IIAGlc are two of the components of the bacterial PTS (phosphoenolpyruvate: sugar phosphotranferase system) and are involved in the phosphorylation and concomitant translocation of sugars across the membrane. These PTS protein complexes also regulate sugar transport. HPr, phosphorylated at a histidine N1 site by Enzyme I and phosphoenol pyruvate, transfers the phosphoryl group to a histidine N3 position in Enzyme IIAGlc. HPrs from Gram-positive bacteria undergo regulatory phosphorylation at Ser46, whereby phosphorylation of the histidine residue is inhibited. Conversely, histidine phosphorylation inhibits phosphorylation at Ser46. HPrs from Gram-negative bacteria possess a serine residue at position 46, but do not undergo regulatory phosphorylation. HPr forms an open-faced sandwich structure with a four-strand S-sheet and 2 to 3 helices lying on top of the sheet. The active-site histidine and Ser46 occur in conformationally flexible regions. P-His-HPr from the Gram-positive bacterium Bacillus subtilus has been investigated by both homonuclear and heteronuclear two-dimensional and three-dimensional NMR experiments using an in-situ enzymatic regeneration system to maintain a constant level of P-His-HPr. The results show that localized conformational changes occur in the vicinity of the active-site histidine and also near Ser46. HPr-Enzyme IIAGlc complexes from both Bacillus subtilis and Gram-negative Escherichia coli were also studied by a variety of 15N-edited two-dimensional NMR experiments, which were performed on uniformly 15N-labeled HPr complexed to unlabeled Enzyme IIAGlc. The complex is in fast exchange with a molecular weight of about 27 kDa. The focus of our work is to assess the changes undergone by HPr (the smaller of the two components), and so all the experiments were performed with excess Enzyme IIA present in the system

  6. A study on decreasing the gaseous radioactive waste production due to the PTS usage in HANARO

    International Nuclear Information System (INIS)

    In Jan, 2001, it occurred that the radioactive gas concentration included in the air exhausted through a duet from the HANARO reactor hall to the atmosphere, sharply increased and it lasted about few seconds. Through the investigation on the operating history of utilization facilities and sampling of reactor hall air, it was revealed that the major isotope was Ar-41 and the sharp increase was related to the usage of PTS for NAA. In addition, several leak spots were found at the PTS pipe joints. The leak spots were sealed and, an experiment to supply nitrogen into the PTS was performed to see the effect of this on the decrease of activation. As result, the average concentration of Ar-41 in the exhausted air decreased from 2.37 x 10-6 μCi/cc to 8.87 x 10-7μCi/cc

  7. Mechanism of phosphoryl transfer and protein-protein interaction in the PTS system-an NMR study

    Energy Technology Data Exchange (ETDEWEB)

    Rajagopal, P.; Klevit, R.E. [Univ. of Washington, Seattle, WA (United States)

    1994-12-01

    HPr and Enzyme IIA{sup Glc} are two of the components of the bacterial PTS (phosphoenolpyruvate: sugar phosphotranferase system) and are involved in the phosphorylation and concomitant translocation of sugars across the membrane. These PTS protein complexes also regulate sugar transport. HPr, phosphorylated at a histidine N1 site by Enzyme I and phosphoenol pyruvate, transfers the phosphoryl group to a histidine N3 position in Enzyme IIA{sup Glc}. HPrs from Gram-positive bacteria undergo regulatory phosphorylation at Ser{sup 46}, whereby phosphorylation of the histidine residue is inhibited. Conversely, histidine phosphorylation inhibits phosphorylation at Ser{sup 46}. HPrs from Gram-negative bacteria possess a serine residue at position 46, but do not undergo regulatory phosphorylation. HPr forms an open-faced sandwich structure with a four-strand S-sheet and 2 to 3 helices lying on top of the sheet. The active-site histidine and Ser{sup 46} occur in conformationally flexible regions. P-His-HPr from the Gram-positive bacterium Bacillus subtilus has been investigated by both homonuclear and heteronuclear two-dimensional and three-dimensional NMR experiments using an in-situ enzymatic regeneration system to maintain a constant level of P-His-HPr. The results show that localized conformational changes occur in the vicinity of the active-site histidine and also near Ser{sup 46}. HPr-Enzyme IIA{sup Glc} complexes from both Bacillus subtilis and Gram-negative Escherichia coli were also studied by a variety of {sup 15}N-edited two-dimensional NMR experiments, which were performed on uniformly {sup 15}N-labeled HPr complexed to unlabeled Enzyme IIA{sup Glc}. The complex is in fast exchange with a molecular weight of about 27 kDa. The focus of our work is to assess the changes undergone by HPr (the smaller of the two components), and so all the experiments were performed with excess Enzyme IIA present in the system.

  8. Pressurized thermal shock (PTS)

    International Nuclear Information System (INIS)

    In the present work, a description of Thermal Shock in Pressurized conditions (PTS), and its influence in the treatment of the integrity of the pressure vessel (RPV) of a Pressurized Water Reactor (PWR) and/or of a Heavy water Pressurized water Reactor (PHWR) is made. Generally, the analysis of PTS involves a process of three stages: a-) Modeling with a System Code of relevant thermohydraulics transients in reference with the thermal shock; b-) The local distribution of temperatures in the downcomer and the heat transference coefficients from the RPV wall to the fluid, are determined; c-) The fracture mechanical analysis. These three stages are included in this work: Results with the thermohydraulics code Relap5/mod.3, are obtained, for a LOCA scenario in the hot leg of the cooling System of the Primary System of the CAN-I reactor. The method used in obtaining results is described. A study on the basis of lumped parameters of the local evolutions of the temperature of the flow is made, in the downcomer of the reactor pressure vessel. The purpose of this study is to determine how the intensification of the stress coefficient, varies in function of the emergency injected water during the thermohydraulic transients that take place under the imposed conditions in the postulated scene. Specially, it is considered a 50 cm2 break, located in the neighborhoods of the pressurized with the corresponding hot leg connection. This size is considered like the most critical. The method used to obtain the results is described. The fracture mechanical analysis is made. From the obtained results we confirmed that we have a simple tool of easy application in order to analyze phenomena of the type PTS in the postulated scenes by break in the cold and hot legs of the primary system. This methodology of calculus is completely independent of the used ones by the Nucleoelectrica Argentina S.A. (NASA) in the analysis of the PTS phenomena in the CAN-I. The results obtained with the adopted

  9. ASSESSMENT OF BONE TISSUE CONDITION BY METHOD OF COMPUTED TOMOGRAPHY IN PTS WITH RHEUMATOID ARTHRITIS

    Directory of Open Access Journals (Sweden)

    T A Raskina

    2002-01-01

    Full Text Available Aim: To estimate the bone mineral density (BMD in patients with dilVerent variants of rheumatoid arthritis (RA. Materials and methods: The study included 65 patients with the acknowledged RA, who were not treated with corticosteroids, basic remedies and antiosteoporosis therapies. The group comprises 26 women оГ reproductive age (I group and 28 women in postmenopause period. The investigations were held with the computer tomograph “Tomoscan” Philips. Results: The comparative analysis of BMD disorders frequency in the studied groups shows that in RA women of postmenopause period osteopenia accounts for 57,1%, osteoporosis - for 32,1% of patients, which is twice as often as in premenopausal women period: 30,8% and 15,4% respectively. BMD levels in RA are correlated with rheumatoid lactor, destructive tendency in bones and high activity of disease.

  10. Mechanical study of the Saclay piezo tuner PTS (piezo tuning system) Care-SRF-WP8

    International Nuclear Information System (INIS)

    The present tuner is working inside Tesla test facility's cryo-modules without any piezo actuator. Thus the Lorentz force detuning in the pulsed mode of the accelerator is limiting the maximum accelerating field of cavity at about 25 MV/m. Previous studies and tests have demonstrated that the integration of piezo actuators in the tuner can lead to the compensation of the Lorentz force detuning at field higher than 35 MV/m. Our goal is now to develop and optimize a new tuner integrating piezo actuators. The mechanical studies are now finished and fabrication is in progress. This report presents the principle of this new system, its design and reviews the cavity frequency shifts during preparation process and assesses the forces applied by the cavity on the piezo actuators. (A.C.)

  11. OECD Nuclear Energy Agency activities on PTS evaluation

    International Nuclear Information System (INIS)

    The Safety Division of the OECD Nuclear Energy Agency provides the secretariat for the Committee on the Safety of Nuclear Installations (CSNI), which deals with technological aspects, and for the Committee for Nuclear Regulatory Activities (CNRA) dealing with regulatory aspects. Under these committees, activities are carried out through five Principal Working Groups (PWGs). The relevant group for PTS is PWG-3 on the integrity of structures and components. There is also PWG-2 on coolant system behavior, but the thermal hydraulic aspects of PTS have not been considered by PWG-2. PWG-3 carries out it work in a similar manner to the IAEA IWG LMNPP, by preparing reports and organizing round robins, Specialists Meetings and Workshops. The general context of RPV PTS has been considered in several workshops: on the 'Complementary roles of Fracture Mechanics and Non-Destructive Examination in the Safety Assessment of Components' in Wuerenlingen in 1988; on the 'Safety Assessment of RPVs' in Espoo in 1990; and on 'Fracture Mechanics Verification by Large Scale Testing' (joint with IAEA) at Oak Ridge in 1992. Activities specific to PTS have been an international survey on regulatory practices on PTS carried out in 1991, and a series of fracture round robins addressing PTS conditions organized by GRS in Germany and ORNL in the USA. 3 refs, 5 tabs

  12. Current pulse shaping of the load current on PTS

    Science.gov (United States)

    Xia, Minghe; Li, Fengping; Ji, Ce; Wei, Bing; Feng, Shuping; Wang, Meng; Xie, Weiping

    2016-02-01

    The typical rise time of PTS machine is ˜110 ns with about 10 MA peak current under short pulse mode when all 24 modules discharge simultaneously. By distributing the trigger times of 12 laser beams logically and adjusting the statues of the pulse output switches, longer rise-time pulse can be obtained on the PTS facility. Based on the required pulse shape, whole circuit simulations will be used to calculate the trigger times of each laser triggering gas switch and the status of the pulse output switches. The rise time of the current is determined by the time difference between the first and last trigged laser triggering gas switches. In order to trigger the laser triggering gas switch, sufficient laser power is needed to be sent into the gap of the gas switches. The gas pressure and voltage difference on the two electrodes of the gas switches also affect the triggering of the gas switches, and the voltage added on the gas switch is determined by its transition time. Traditionally the trigger time difference should be less than the transition time of the two neighboring modules. A new simulation model of PTS shows one can break this transition time limits. Series of current pulse shaping experiments have been investigated on the PTS (Primary Test Stand). As results, more than 5 MA peak current were successfully achieved on the load with a rise time of 600 ns. This study and experiments of the pulse shaping on PTS demonstrate the adaptable ability of the PTS for offering different waveform of mega ampere current pulse for different research purpose.

  13. Current pulse shaping of the load current on PTS

    Directory of Open Access Journals (Sweden)

    Minghe Xia

    2016-02-01

    Full Text Available The typical rise time of PTS machine is ∼110 ns with about 10 MA peak current under short pulse mode when all 24 modules discharge simultaneously. By distributing the trigger times of 12 laser beams logically and adjusting the statues of the pulse output switches, longer rise-time pulse can be obtained on the PTS facility. Based on the required pulse shape, whole circuit simulations will be used to calculate the trigger times of each laser triggering gas switch and the status of the pulse output switches. The rise time of the current is determined by the time difference between the first and last trigged laser triggering gas switches. In order to trigger the laser triggering gas switch, sufficient laser power is needed to be sent into the gap of the gas switches. The gas pressure and voltage difference on the two electrodes of the gas switches also affect the triggering of the gas switches, and the voltage added on the gas switch is determined by its transition time. Traditionally the trigger time difference should be less than the transition time of the two neighboring modules. A new simulation model of PTS shows one can break this transition time limits. Series of current pulse shaping experiments have been investigated on the PTS (Primary Test Stand. As results, more than 5 MA peak current were successfully achieved on the load with a rise time of 600 ns. This study and experiments of the pulse shaping on PTS demonstrate the adaptable ability of the PTS for offering different waveform of mega ampere current pulse for different research purpose.

  14. Impact of ECCS design of VVER reactors on PTS issue

    International Nuclear Information System (INIS)

    In 1996, a study of Pressurized Thermal Shock (PTS) was started in the Nuclear Research Institute Rez (UJV) covering the NPPs operated in the Czech Republic. PTS analyses for NPP Dukovany (VVER-440/213) have been performed first and later a similar study was initiated for NPP Temelin (VVER-1000/320). Our PTS analyses produced many interesting interim results concerning design of Emergency Core Cooling System (ECCS). The presented paper deals with these findings and summarizes possible improvements of ECCS from the point of view of PTS issue. In general, it can be said that design of ECCS system of VVER (or PWR) was previously focused, more or less, only to emergency core cooling and containment spraying, and no (or minimal) attention was paid to PTS issue. However, the injection of cold water from the ECCS system (during an accident with ECCS actuation) is potentially a major contributor to rapid cooldown of reactor coolant system (RCS), where especially the fast and unsymmetrical temperature drop in reactor downcomer (DC) could challenge the reactor pressure vessel (RPV) integrity. The fast decrease of coolant temperature in DC would lead to a significant increase of thermal stresses in the thick wall of embrittled RPV. Consequently, these thermal stresses together with stresses from inner pressure could in conditions of relatively cold RPV material initiate a fast fracture from a flaw potentially existing in the RPV wall. Nowadays it is obvious that the ECCS design should take into account not only the needs of emergency cooling of the reactor core (and containment spraying), but also the PTS issue. The ECCS design should be optimized from all these points of view. This is however not an easy task, because requirements of core cooling and minimization of PTS risks are usually contradictory. Naturally, this challenging task would be easier to fulfill while designing a new NPP (VVER or PWR in general). However, it is possible to improve the ECCS design and thus

  15. Study on Technology and Improved PTS Algorithm for PAPR Reduction in OFDM System%OFDM系统中降峰均比研究及PTS改进算法

    Institute of Scientific and Technical Information of China (English)

    何维武; 冯辉

    2011-01-01

    正交频分复用(OFDM)技术在解决无线移动通信系统中显示了许多特点,如抗多路径衰落和频际间的干扰等.然而,OFDM系统中一个最主要的瓶颈在于OFDM信号的峰均功率比(PAPR,Peak-to-Average Power Ratio)很大,因而容易导致OFDM信号的交调失真和系统性能的下降.如何有效地解决OFDM系统中的峰均功率比是亟待解决的问题.为此,提出一种新的PTS(部分传输序列)改进算法.

  16. The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS in Corynebacterium glutamicum

    Directory of Open Access Journals (Sweden)

    Hartmann Michelle

    2007-11-01

    Full Text Available Abstract Background The major uptake system responsible for the transport of fructose, glucose, and sucrose in Corynebacterium glutamicum ATCC 13032 is the phosphoenolpyruvate:sugar phosphotransferase system (PTS. The genes encoding PTS components, namely ptsI, ptsH, and ptsF belong to the fructose-PTS gene cluster, whereas ptsG and ptsS are located in two separate regions of the C. glutamicum genome. Due to the localization within and adjacent to the fructose-PTS gene cluster, two genes coding for DeoR-type transcriptional regulators, cg2118 and sugR, are putative candidates involved in the transcriptional regulation of the fructose-PTS cluster genes. Results Four transcripts of the extended fructose-PTS gene cluster that comprise the genes sugR-cg2116, ptsI, cg2118-fruK-ptsF, and ptsH, respectively, were characterized. In addition, it was shown that transcription of the fructose-PTS gene cluster is enhanced during growth on glucose or fructose when compared to acetate. Subsequently, the two genes sugR and cg2118 encoding for DeoR-type regulators were mutated and PTS gene transcription was found to be strongly enhanced in the presence of acetate only in the sugR deletion mutant. The SugR regulon was further characterized by microarray hybridizations using the sugR mutant and its parental strain, revealing that also the PTS genes ptsG and ptsS belong to this regulon. Binding of purified SugR repressor protein to a 21 bp sequence identified the SugR binding site as an AC-rich motif. The two experimentally identified SugR binding sites in the fructose-PTS gene cluster are located within or downstream of the mapped promoters, typical for transcriptional repressors. Effector studies using electrophoretic mobility shift assays (EMSA revealed the fructose PTS-specific metabolite fructose-1-phosphate (F-1-P as a highly efficient, negative effector of the SugR repressor, acting in the micromolar range. Beside F-1-P, other sugar-phosphates like fructose

  17. Two-Phase Flow Simulations for PTS Investigation by Means of Neptune_CFD Code

    OpenAIRE

    Fabio Moretti; Maria Cristina Galassi; Pierre Coste; Christophe Morel

    2009-01-01

    Two-dimensional axisymmetric simulations of pressurized thermal shock (PTS) phenomena through Neptune_CFD module are presented aiming at two-phase models validation against experimental data. Because of PTS complexity, only some thermal-hydraulic aspects were considered. Two different flow configurations were studied, occurring when emergency core cooling (ECC) water is injected in an uncovered cold leg of a pressurized water reactor (PWR)—a plunging water jet entering a free surface, an...

  18. Fidelity of Implementing an Assessment Translation and Adaptation Framework in a Study of an Emerging International Assessment

    Science.gov (United States)

    Chia, Magda Yanira

    2012-01-01

    This study addresses the complex process of translation and adaptation of two Collegiate Learning Assessment (CLA) performance tasks (PTs), originally developed in English for American students, into the languages and cultures of five participating countries. Focusing on confirming evidence bits (CEBs), disconfirming evidence bits (DEBs), and no…

  19. A Novel PTS of Streptococcus mutans is Responsible for Transport of Carbohydrates with α-1,3 linkage

    Science.gov (United States)

    Ajdic, Dragana; Chen, Zhiyun

    2012-01-01

    SUMMARY The most common type of carbohydrate-transport system in Streptococcus mutans is the phosphoenolpyruvate (PEP)-sugar phosphotransferase system (PTS). We previously showed that fourteen PTSs exist in S. mutans UA159 (Ajdic et al., 2002). Several studies have shown that microorganisms growing in biofilms express different genes as compared to their planktonic counterparts. In this study, we showed that one PTS of S. mutans was expressed in sucrose-grown biofilms. Furthermore, the same PTS was also responsible for the transport and metabolism of disaccharide nigerose (3-O-α-D-glucopyranosyl-D-glucose). Additionally, the results indicate that the studied PTS might be involved in the transport and metabolism of carbohydrates synthesized by glucosyltransferase B (GtfB) and glucosyltransferase C (GtfC) of S. mutans. To our knowledge, this is the first report that shows PTS transport of a disaccharide (and possibly extracellular oligosaccharides) with α-1,3 linkage. PMID:23193985

  20. Influence of combined therapy with prospidin and methotrexate on radiological progression, functional status and quality of life in pts with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    O. V. Simonova

    2004-01-01

    Full Text Available Objective. To evaluate influence of combination therapy with prospidin (P and methotrexate (MTX on X-ray progression, functional status (FS and quality of life (QL in patients with rheumatoid arthritis (RA in comparison with MTX monotherapy. Material and methods. 143 RA pts (129 female and 14 male were studied. Of them, there were. Mean age was 45.5±5.l years. Average duration of the disease was 4.5 years. 20 pts had II and 123 - 111 degree of RA activity. The second X-ray stage according to Steinbroker dominated. 72 pts of group I received P+MTX combination therapy. The therapy included intravenous drip-feed of P 200-300 mg per week in 200ml of 5% glucose and MTX 10 mg per week 1M. The maintaining therapy included P 100-200 mg per week IM and MTX 10 mg per week. 71 patients of group II received MTX monotherapy 10 mg per week. X-ray progression assessment was performed according to Sharp method. FS was evaluated with the HAQ questionnaire, Lee test. QL was evaluated with SF-36 scale. Pts were examined before and after I, 2, 3, 6 and 12 months of treatment. Results. There was no increase of X-ray progression of the disease in case of P+MTX therapy as compared with MTX monotherapy. Both methods resulted in improvement of FS parameters and physical health. Combination therapy significantly improved psychological health as well.

  1. Emerging Theoretical Models of Reading through Authentic Assessments among Preservice Teachers: Two Case Studies

    Science.gov (United States)

    Oboler, Eileen S.; Gupta, Abha

    2010-01-01

    This two-part study examines the emerging understanding of the reading process among preservice teachers (PTs), enrolled in a teacher preparation course on diagnostic reading. The study focuses on the use of reading assessment tools to understand the process of reading, while using reading inventories for diagnostic as well as pedagogical…

  2. Influence of radiation on endotoxin test using the PTS TM for 18-FDG radiopharmaceutical

    Directory of Open Access Journals (Sweden)

    Ralph Santos-Oliveira

    2010-09-01

    Full Text Available F-18 FDG (2-[18-F] fluoro-2-deoxy-D-glucose is the most frequently used radiopharmaceutical for PET and PET CT imaging exams. The FDA recently approved the use of the PTS TM (Portable Test System as an alternative to the standard test proposed by the United States Pharmacopeia using the LAL (Limulus Amebocyte Lysates, that takes longer to perform (about 1h than the PTS TM (15 min. Recent studies have demonstrated that radiation could interfere with the PTS TM test. In order to study the effects of radiation on the PTS TM test and/or equipment, 27 batches of F-18 FDG produced in the Nuclear Engineering Institute were analyzed. The results showed that no direct correlation with radiation was found in any of the cases.O FDG-18 é o radiofármaco mais utilizado nos exames de PET e PET CT. O FDA recentemente aprovou o uso do PTS TM (Portable Test System como método alternativo ao teste padrão de endotoxina, proposto pela Farmacopéia Americana, considerando que no primeiro há um tempo de espera de 1 hora frente a somente 15 minutos do segundo. Estudo recentes demonstram que a radiação poderia interferir no teste do PTS TM. De modo a avaliar os efeitos da radiação no teste PTS TM foram analisados 27 lotes de F-18 FDG produzidos no Instituto de Engenharia Nuclear. Os resultados demonstraram que em todos os casos nenhuma correlação direta com a radiação foi observada.

  3. Diagnostics for Z-pinch implosion experiments on PTS

    Science.gov (United States)

    Ren, X. D.; Huang, X. B.; Zhou, S. T.; Zhang, S. Q.; Dan, J. K.; Li, J.; Cai, H. C.; Wang, K. L.; Ouyang, K.; Xu, Q.; Duan, S. C.; Chen, G. H.; Wang, M.; Feng, S. P.; Yang, L. B.; Xie, W. P.; Deng, J. J.

    2014-12-01

    The preliminary experiments of wire array implosion were performed on PTS, a 10 MA z-pinch driver with a 70 ns rise time. A set of diagnostics have been developed and fielded on PTS to study pinch physics and implosion dynamics of wire array. Radiated power measurement for soft x-rays was performed by multichannel filtered x-ray diode array, and flat spectral responses x-ray diode detector. Total x-ray yield was measured by a calibrated, unfiltered nickel bolometer which was also used to obtain pinch power. Multiple time-gated pinhole cameras were used to produce spatial-resolved images of x-ray self-emission from plasmas. Two time-integrated pinhole cameras were used respectively with 20-μm Be filter and with multilayer mirrors to record images produced by >1-keV and 277±5 eV self-emission. An optical streak camera was used to produce radial implosion trajectories, and an x-ray streak camera paired with a horizontal slit was used to record a continuous time-history of emission with one-dimensional spatial resolution. A frequency-doubled Nd:YAG laser (532 nm) was used to produce four frame laser shadowgraph images with 6 ns time interval. We will briefly describe each of these diagnostics and present some typical results from them.

  4. Diagnostics for Z-pinch implosion experiments on PTS

    Energy Technology Data Exchange (ETDEWEB)

    Ren, X. D., E-mail: amosrxd@163.com; Huang, X. B., E-mail: amosrxd@163.com; Zhou, S. T., E-mail: amosrxd@163.com; Zhang, S. Q., E-mail: amosrxd@163.com; Dan, J. K., E-mail: amosrxd@163.com; Li, J., E-mail: amosrxd@163.com; Cai, H. C., E-mail: amosrxd@163.com; Wang, K. L., E-mail: amosrxd@163.com; Ouyang, K., E-mail: amosrxd@163.com; Xu, Q., E-mail: amosrxd@163.com; Duan, S. C., E-mail: amosrxd@163.com; Chen, G. H., E-mail: amosrxd@163.com; Wang, M., E-mail: amosrxd@163.com; Feng, S. P., E-mail: amosrxd@163.com; Yang, L. B., E-mail: amosrxd@163.com; Xie, W. P., E-mail: amosrxd@163.com; Deng, J. J., E-mail: amosrxd@163.com [Key Lab of Pulsed Power, Institute of Fluid Physics, CAEP, P.O. Box 919-108, Mianyang, Sichuan 621999 (China)

    2014-12-15

    The preliminary experiments of wire array implosion were performed on PTS, a 10 MA z-pinch driver with a 70 ns rise time. A set of diagnostics have been developed and fielded on PTS to study pinch physics and implosion dynamics of wire array. Radiated power measurement for soft x-rays was performed by multichannel filtered x-ray diode array, and flat spectral responses x-ray diode detector. Total x-ray yield was measured by a calibrated, unfiltered nickel bolometer which was also used to obtain pinch power. Multiple time-gated pinhole cameras were used to produce spatial-resolved images of x-ray self-emission from plasmas. Two time-integrated pinhole cameras were used respectively with 20-μm Be filter and with multilayer mirrors to record images produced by >1-keV and 277±5 eV self-emission. An optical streak camera was used to produce radial implosion trajectories, and an x-ray streak camera paired with a horizontal slit was used to record a continuous time-history of emission with one-dimensional spatial resolution. A frequency-doubled Nd:YAG laser (532 nm) was used to produce four frame laser shadowgraph images with 6 ns time interval. We will briefly describe each of these diagnostics and present some typical results from them.

  5. Construct validity of Croatian version of the Pavlovian Temperament Survey (PTS

    Directory of Open Access Journals (Sweden)

    Sanja Tatalović Vorkapić

    2012-10-01

    Full Text Available The aim of this study was to examine the construct validity of Pavlovian Temperament Survey (PTS by determining the relationship between three Strelau's dimensions of temperament (strength of excitation, strength of inhibition, mobility and basic dimensions of personality as were defined by Eysenck and in the five-factor model of personality. It was expected that strength of excitation and mobility would have significant positive correlations with extraversion and negative correlations with neuroticism, while strength of inhibition would show significant negative correlations with neuroticism. Within two studies (N1 = 74 female students, Mage = 22; N2 = 54 female students, Mage = 20, Croatian version of PTS, Five−Factor Nonverbal Personality Questionnaire FF−NPQ, and Eysenck's Personality Questionnaire EPQ R/A were used. The reliability coefficients for all three instruments were satisfactory, although not very high. Coefficients of correlation determined in the first study were not entirely in agreement with either theoretical expectations or empirical results of other authors, probably due to small sample size. However, the results of the second study were in accord with the expected pattern of significant correlations and that could be considered an indicator of good construct validity of PTS. Since this was a preliminary study the results provide only a general insight into the research aim, and represent a good starting point for future validation studies of the Croatian version of PTS.

  6. A probabilistic approach to the evaluation of the PTS issue

    International Nuclear Information System (INIS)

    An integrated probabilistic approach for the evaluation of the pressurized-thermal-shock (PTS) issue was developed at the Oak Ridge National Laboratory (ORNL) at the request of the Nuclear Regulatory Commission (NRC). The purpose was to provide a method for identifying dominant plant design and operating features, evaluating possible remedial measures and the validity of the NRC PTS screening criteria, and to provide an additional tool for estimating vessel life expectancy. The approach was to be integrated in the sense that it would include the postulation of transients; estimates of their frequencies of occurrence; systems analyses to obtain the corresponding primary-system pressure, down-comer coolant temperature, and fluid-film heat-transfer coefficient adjacent to the vessel wall; and a probabilistic fracture-mechanics analysis, using the latter data as input. A summation of the products of frequency of transient and conditional probability of failure for all postulated transients provides an estimate of frequency of vessel failure. In the process of developing the integrated pressurized-thermal-shock (IPTS) methodology, three specific plant analyses were conducted. The results indicate that the NRC screening criteria may not be appropriate for all US pressurized water reactor (PWR) plants; that is, for some PWRs, the calculated mean frequency of vessel failure corresponding to the screening criteria may be greater than the maximum permissible value in Regulatory Guide 1.154. A recent view of the ORNL IPTS study, which was completed in 1985, indicates that there are a number of areas in which the methodology can and should be updated, but it is not clear whether the update will increase or decrease the calculated probabilities. 31 refs., 2 tabs

  7. TOPFLOW-PTS experiments. pre-test calculations with NEPTUNECFD code

    International Nuclear Information System (INIS)

    Hypothetical Small Break Loss Of Coolant Accident is identified as one of the most severe transients leading to a potential huge Pressurized Thermal Shock on the Reactor Pressure Vessel (RPV). This may result in two-phase flow configurations in the cold legs, according to the operating conditions, and to reliably assess the RPV wall integrity, advanced two-phase flow simulations are required. Related needs in development and/or validation of these advanced models are important, and the on-going TOPFLOW-PTS experimental program was designed to provide a well documented data base to meet these needs. This paper focuses on pre-test NEPTUNECFD simulations of TOPFLOW-PTS experiments; these simulations were performed to (i) help in the definition of the test matrix and test procedure, and (ii) check the presence of the different key physical phenomena at the mock-up scale. (author)

  8. Fluorescent co-localization of PTS1 and PTS2 and its application in analysis of the gene function and the peroxisomal dynamic in Magnaporthe oryzae

    Institute of Scientific and Technical Information of China (English)

    Jiao-yu WANG; Fu-cheng LIN; Guo-chang SUN; Xiao-yan WU; Zhen ZHANG; Xin-fa DU; Rong-yao CHAI; Xiao-hong LIU; Xue-qin MAO; Hai-ping QIU; Yan-li WANG

    2008-01-01

    The peroxisomal matrix proteins involved in many important biological metabolism pathways in eukaryotic cells are encoded by nucleal genes, synthesized in the cytoplasm and then transported into the organelles. Targeting and import of these proteins depend on their two peroxisomal targeting signals (PTS1 and PTS2) in sequence as we have known so far. The vectors of the fluorescent fusions with PTS, i.e., green fluorescence protein (GFP)-PTSI, GFP-PTS2 and red fluorescence protein (RFP)-PTS1, were constructed and introduced into Magnaporthe oryzae Guy11 cells. Transformants containing these fusions emitted fluorescence in a punctate pattern, and the locations of the red and green fluorescence overlapped exactly in RFP-PTS1 and GFP-PTS2 co-transformed strains. These data indicated that both PTS 1 and PTS2 fusions were imported into peroxisomes. A probable higher efficiency of PTSI machinery was revealed by comparing the fluorescence backgrounds in GFP-PTS1 and GFP-PTS2 transformants. By introducing both RFP-PTS1 and GFP-PTS2 into △mgpex6 mutants, the involvement of MGPEX6 gene in both PTS1 and PTS2 pathways was proved. In addition, using these transformants, the inducement of peroxisomes and the dynamic of peroxisomal number during the pre-penetration processes were investigated as well. In summary, by the localization and co-localization of PTSI and PTS2, we provided a useful tool to evaluate the biological roles of the peroxisomes and the related genes.

  9. Thermal hydraulic behavior during main steam line break in PTS evaluation of Kori Unit 1

    International Nuclear Information System (INIS)

    The present study primarily aims to evaluate the system thermal hydraulic and thermal mixing behavior in downcomer of a postulated Main Steam Line Break (MSLB) as one of the major PTS (Pressurized Thermal Shock) initiators in PTS Evaluation of Kori Unit 1. For this purpose, the MSLB event sequences were reviewed and the most severe event sequence was selected based on the peer review on design and operational features. Based on the present design and operation condition of Kori Unit 1, a base calculation of the most severe sequence of MSLB events is conducted using RELAP5 and the sensitivity of the thermal-hydraulic mixing in downcomer was also investigated. The current result shows an overall downcomer fluid cooling from 558degK to 436degK. From the sensitivity analysis results, it is found that the thermal mixing could be affected by the downcomer modeling. (author)

  10. About molecular characteristic peripheral blood lymphocytes in pts with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    I. R. Kolosova

    2003-01-01

    Full Text Available Objective. To study lymphocytes phenotype in rheumatoid arthritis (RA and its changes during methotrexate (MT therapy. Methods. 24 RA pts with high clinical and laboratory activity of the disease and 18 healthy donors (control group were included. All patients received MT 7,5-15 mg/week. They were followed up for 6 months. Expression of CD3, CD5, CD7, CD8, CD16, CD18, CD19, CD20, CD25, CD26, CD50, CD54, HLA DR, CD95 on peripheral blood lymphocytes was assessed before and after treatment by immunofluorescence method. Results. There was decreased expression of CD8, CD18, and CD50 in RA patients vs control. MT treatment resulted in reduction of CD 50 and CD 26 expression on lymphocytes. Conclusion. Peripheral blood in RA is characterized by decrease of CD8+ lymphocyte percent. Reduction of CD 18 and CD50 adhesion molecules expression may be connected with migration of appropriate effector cells bearing these molecules on there surface into inflamed synovial membrane. Treatment with MT decreased expression of some adhesion molecules. Decrease of CD 26 lymphocytes activation marker expression is one of the mechanisms of MT antirheumatic action.

  11. Role of crack arrest in the evaluation of PWR pressure vessel integrity during PTS transients

    International Nuclear Information System (INIS)

    The PWR pressurized thermal-shock (PTS) issue, which is concerned with the integrity of the reactor pressure vessel during postulated overcooling transients, is under intensive investigation by the USNRC. The USNRC-sponsored Integrated Pressurized Thermal-Shock (IPTS) and Heavy-Section Steel Technology (HSST) Programs are dedicated to a better understanding and a timely resolution of the problem. The HSST program is investigating flaw behavior in large cylinders and is also obtaining fracture-mechanics-related material properties, while the IPTS program is primarily concerned with an estimation of the overall frequency of vessel failure and identification of dominant transients and design and operating features contributing thereto for specific nuclear plants. One important component of the IPTS study is a probabilistic fracture-mechanics analysis of the reactor vessel, and a point of particular interest therein is the role of crack arrest in mitigating the consequences of the postulated PTS transients. The HSST program has provided crack-arrest data from small specimens and large thermally and pressure-loaded cylinders that tend to establish the validity of the crack-arrest concept for application to the PTS problem. Unfortunately, recent results of the IPTS studies indicate that the inclusion of crack arrest in the probabilistic fracture-mechanics model does not substantially influence the calculated frequency of vessel failure. However, there are still significant questions regarding flaw behavior at upper-shelf temperatures, and the HSST program is continuing to pursue this area of uncertainty

  12. Clinical impact of FDG PET scanning in colon cancer patients: a prospective study

    International Nuclear Information System (INIS)

    Full text: PET scanning using FDG accurately stages patients (pts) with complications arising some time after initial treatment of colorectal cancer. This prospective study assessed how the FDG PET scan results affected management in 42 such pts (33 males, mean age 64 ± 12, range 32-88 years), where clinical doubt remained about their stage after routine assessment, including conventional imaging (CI). Prior to PET scanning, referring doctors were asked why it was needed, to stage their pts according to available data and indicate probable management plans. Follow-up of subsequent management which occurred post-PET was obtained and compared to pre-scan plans. After PET scanning, 14 pts (33%) were converted from aggressive treatment of suspected locoregional disease to palliative therapy after discovery of distant undetected but subsequently confirmed metastases. A further 8 pts (19%) had treatment changed (2 pts: surgery to follow-up; 2 pts: radiotherapy field changed; 4 pts: surgery to medical therapy). Nine patients were cleared for surgery but 2/6 were found to be inoperable due to small metastases ( < 1 cm) not detected on PET or Cl. In 11 pts, continued clinical observation followed negative PET. PET found occult tumour in 2/4 pts with rising CEA but negative CI. Of 17 pts deemed operable on CI, only 6 were considered surgical candidates following PET. In summary, in carefully selected patients with previously treated colorectal cancer, PET scanning significantly altered management in 21/41 (52%.). The significant reduction in surgery provided a significant cost saving in this population. A clear PET scan in patients with otherwise operative disease does not always exclude small volume metastases

  13. Characterization, prediction and evolution of plant peroxisomal targeting signals type 1 (PTS1s).

    Science.gov (United States)

    Reumann, S; Chowdhary, G; Lingner, T

    2016-05-01

    Our knowledge of the proteome of plant peroxisomes and their functional plasticity is far from being complete, primarily due to major technical challenges in experimental proteome research of the fragile cell organelle. Several unexpected novel plant peroxisome functions, for instance in biotin and phylloquinone biosynthesis, have been uncovered recently. Nevertheless, very few regulatory and membrane proteins of plant peroxisomes have been identified and functionally described up to now. To define the matrix proteome of plant peroxisomes, computational methods have emerged as important powerful tools. Novel prediction approaches of high sensitivity and specificity have been developed for peroxisome targeting signals type 1 (PTS1) and have been validated by in vivo subcellular targeting analyses and thermodynamic binding studies with the cytosolic receptor, PEX5. Accordingly, the algorithms allow the correct prediction of many novel peroxisome-targeted proteins from plant genome sequences and the discovery of additional organelle functions. In this review, we provide an overview of methodologies, capabilities and accuracies of available prediction algorithms for PTS1 carrying proteins. We also summarize and discuss recent quantitative, structural and mechanistic information of the interaction of PEX5 with PTS1 carrying proteins in relation to in vivo import efficiency. With this knowledge, we develop a model of how proteins likely evolved peroxisomal targeting signals in the past and still nowadays, in which order the two import pathways might have evolved in the ancient eukaryotic cell, and how the secondary loss of the PTS2 pathway probably happened in specific organismal groups. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. PMID:26772785

  14. PTS Phosphorylation of Mga Modulates Regulon Expression and Virulence in the Group A Streptococcus

    OpenAIRE

    Hondorp, Elise R.; Hou, Sherry C.; Hause, Lara L.; Gera, Kanika; Lee, Ching-En; McIver, Kevin S.

    2013-01-01

    The ability of a bacterial pathogen to monitor available carbon sources in host tissues provides a clear fitness advantage. In the group A streptococcus (GAS), the virulence regulator Mga contains homology to phosphotransferase system (PTS) regulatory domains (PRDs) found in sugar operon regulators. Here we show that Mga was phosphorylated in vitro by the PTS components EI/HPr at conserved PRD histidines. A ∆ptsI (EI-deficient) GAS mutant exhibited decreased Mga activity. However, PTS-mediate...

  15. Molecular Recognition of PTS-1 Cargo Proteins by Pex5p: Implications for Protein Mistargeting in Primary Hyperoxaluria

    Directory of Open Access Journals (Sweden)

    Noel Mesa-Torres

    2015-02-01

    Full Text Available Peroxisomal biogenesis and function critically depends on the import of cytosolic proteins carrying a PTS1 sequence into this organelle upon interaction with the peroxin Pex5p. Recent structural studies have provided important insights into the molecular recognition of cargo proteins by Pex5p. Peroxisomal import is a key feature in the pathogenesis of primary hyperoxaluria type 1 (PH1, where alanine:glyoxylate aminotransferase (AGT undergoes mitochondrial mistargeting in about a third of patients. Here, we study the molecular recognition of PTS1 cargo proteins by Pex5p using oligopeptides and AGT variants bearing different natural PTS1 sequences, and employing an array of biophysical, computational and cell biology techniques. Changes in affinity for Pex5p (spanning over 3–4 orders of magnitude reflect different thermodynamic signatures, but overall bury similar amounts of molecular surface. Structure/energetic analyses provide information on the contribution of ancillary regions and the conformational changes induced in Pex5p and the PTS1 cargo upon complex formation. Pex5p stability in vitro is enhanced upon cargo binding according to their binding affinities. Moreover, we provide evidence that the rational modulation of the AGT: Pex5p binding affinity might be useful tools to investigate mistargeting and misfolding in PH1 by pulling the folding equilibria towards the native and peroxisomal import competent state.

  16. The influence of finite-length flaw effects on PTS analyses

    International Nuclear Information System (INIS)

    Current licensing issues within the nuclear industry dictate a need to investigate the effects of cladding on the extension of small finite-length cracks near the inside surface of a vessel. Because flaws having depths of the order of the combined clad and heat affected zone thickness dominate the frequency distribution of flaws, their initiation probabilities can govern calculated vessel failure probabilities. Current pressurized-thermal-shock (PTS) analysis computer programs recognize the influence of the inner-surface cladding layer in the heat transfer and stress analysis models, but assume the cladding fracture toughness is the same as that for the base material. The programs do not recognize the influence cladding may have in inhibiting crack initiation and propagation of shallow finite-length surface flaws. Limited experimental data and analyses indicate the cladding can inhibit the propagation of certain shallow flaws. This paper describes an analytical study which was carried out to determine (1) the minimum flaw depth for crack initiation under PTS loading for semicircular surface flaws in a clad reactor pressure vessel and (2) the impact, in terms of the conditional probability of vessel failure, of using a semicircular surface flaw as the initial flaw and assuming that the flaw cannot propagate in the cladding. The analytical results indicate that for initiation a much deeper critical crack depth is required for the finite-length flaw than for the infinite-length flaw, except for the least severe transient. The minimum flaw depths required for crack initiation from the finite-length flaw analyses were incorporated into a modified version of the OCA-P code. The modified code was applied to the analysis of selected PTS transients, and the results produced a substantial decrease in the conditional probability of failure. This initial study indicates a significant effect on probabilistic fracture analyses by incorporating finite-length flaw results

  17. Factors which influence quality of life in patients with non-small cell lung cancer (NSCLC): A radiation therapy oncology group study (RTOG 89-01)

    International Nuclear Information System (INIS)

    Purpose: Prospectively evaluate the quality of life (QOL) of patients with NSCLC participating in a randomized phase III study conducted by the RTOG and Eastern Cooperative Oncology Group. Determine the factors which influence QOL during and post therapy. Materials and Methods: From (4(90)) to (4(94)) to 75 patients (pts) were randomized on RTOG 89-01 between a regimen containing radiation therapy (RT) versus a regimen containing surgery (S). All pts received induction vinblastine and cisplatin, followed by either S or RT and consolidation chemotherapy (CT). Pts were given the self-assessment QOL forms prior to the start of therapy, post induction CT, post RT or S, and periodically during follow-up. Two questionnaires were used: Functional Assessment of Cancer Therapy for lung cancer patients (FACT-L) and Functional Living Index-Cancer (FLIC). The FACT-L consists of 44 questions covering 6 domains (physical, social, and emotional well-being, relationship with physician, fulfilment, and lung cancer specific concerns), FLIC contains 22 questions summing to one total score. Results: 51 pts participated in the QOL endpoint, 24 were excluded: 3 pts refused, institution did not administer QOL questionnaires in 9 pts, 3 completed QOL after start of therapy, 1 institution refused to participate, 5 questionnaires were incomplete/unusable, 1 pt could not read English, and 2 were ineligible for treatment. Participation in QOL was not predicted by any pretreatment characteristic. Women had worse pretreatment QOL (p<0.005, by FLIC) and more problems with disease-related symptoms (p<0.005, by FACT) than men. Pts with KPS 90-100 had better pretreatment QOL than pts with KPS 60-80 (p<0.025, FLIC). Neither race, marital status, education level, age, prior weight loss, nor disease symptoms statistically significantly influenced pretreatment QOL. Initial QOL did not predict overall survival. FACT-L was reported on 25 pts post induction CT. Follow-up FACT-L was available on 12 pts

  18. General overview of the TOPFLOW-PTS experimental program

    International Nuclear Information System (INIS)

    During a hypothetical loss-of-coolant accident, cold emergency core cooling water may be injected in a partially uncovered cold leg, and related two-phase CFD simulations are required to demonstrate the reactor pressure vessel integrity further to the resulting pressurized thermal shock. To complement the physical validation of the two-phase CFD codes in this configuration, a dedicated integral-type experimental program - TOPFLOW-PTS - has been setup; this paper (i) supports the validation data needs, (ii) presents the related experimental setup, and (iii) provides the general guidelines of the test matrix definition and test procedure. (author)

  19. Quality of life characteristics in assessment of diclofenac and Nise® efficacy in patients with gonarthritis

    Directory of Open Access Journals (Sweden)

    L V Sizova

    2003-01-01

    Full Text Available Objective. To study efficacy and safety of diclofenac and Nise® application in pts with gonarthritis. Material and methods. 60 pts with gonarthritis were included (mean age 53,4±9,5 years, mean disease duration 7,4±6,8 years. Quality of life was assessed with 4 questionnaires: Modified Stanford Health Assessment Questionnaire (MHAQ, SF-36, Nottingham Health Profile (NHP, Knee injury and Osteoarthritis Outcome Score (KOOS. 30 pts of group I received diclofenac 75 mg/day, 30 pis of group 11 were treated with Nise® 200 mg/day for 10 days. Multi-vitamins "Decamevitum" and injections of Xantinoli nicotinatis were used as additional treatment. Results. Diclofenac and Nise® showed good analgesic and anti-inflammatory effect. Both provided quality of life improvement in pts with gonarthrosis. Nise® was better tolerated.

  20. Role of crack arrest in the evaluation of PWR pressure vessel integrity during PTS transients

    Energy Technology Data Exchange (ETDEWEB)

    Cheverton, R.D.; Ball, D.G.

    1984-01-01

    The HSST program is investigating flaw behavior in large cylinders and is also obtaining fracture-mechanics-related material properties, while the Integrated Pressurized Thermal-Shock (IPTS) program is primarily concerned with an estimation of the overall frequency of vessel failure and identification of dominant transients and design and operating features contributing thereto for specific nuclear plants. One important component of the IPTS study is a probabilistic fracture-mechanics analysis of the reactor vessel, and a point of particular interest therein is the role of crack arrest in mitigating the consequences of the postulated PTS transients. The HSST program has provided crack-arrest data from small specimens and large thermal- and pressure-loaded cylinders that tend to establish the validity of the crack-arrest concept for application to the PTS problem. Unfortunately, recent results of the IPTS studies indicate that the inclusion of crack arrest in the probabilistic fracture-mechanics model does not substantially influence the calculated frequency of vessel failure. However, there are still significant questions regarding flaw behavior at upper-shelf temperatures, and the HSST program is continuing to pursue this area of uncertainty.

  1. PAPR Reduction in OFDM Using Partial Transmit Sequence (PTS

    Directory of Open Access Journals (Sweden)

    R.Gayathri

    2013-04-01

    Full Text Available In recent years, OFDM has gained a lot of interest in diverse-digital communication applications. This has been due to its favorable properties like high spectral efficiency and robustness to channel fading. Some of the major drawbacks in OFDM are its high peak-to-average-power ratio(PAPR of the transmitted signals and the synchronization of signals. OFDM consist of large number of independent subcarriers, as a result of which the amplitude of such a signal can have high peak values. Coding, phase rotation and clipping are among many PAPR reduction schemes that have been proposed to overcome this problem. Significant reduction in PAPR has been achieved using Partial Transmit Sequence(PTS which comes under Signal scrambling techniques.

  2. Values of functional indexes in assessment of efficacy of osteoarthritis treatment with Chondrolon and Zel T in polyclinic

    Directory of Open Access Journals (Sweden)

    O Y Maiko

    2009-01-01

    Full Text Available Objective. To study change of knee joints functional disability in pts with predominantly I-II stage of knee osteoarthritis (OA with clinical tests and WOMAC index for assessment of efficacy of treatment with Chondrolon and Zel T in polyclinic. Material and methods. 70 pts with I and II stage of OA according to Kellgren-Lawrence aged from 40 to 67 years were included. They were divided in 2 groups (30 pts in group I and40 pts in group II. Group I pts were treated with Chondrolon and group II pts – with Zel T. Treatment efficacy was assessed with WOMAC index, functional Lequesne index, pain on VAS at rest and at movement, knee mobility, time of walking for 30 m and walking stairs. Results. Positive changes of all parameters were revealed in both groups: significant improvement of pain on VAS, functional tests, Lequesne index, WOMAC scales was achieved. During treatment with Zel T improvement of the efficacy measures increased slower, mainly after 12 weeks of treatment (during treatment with Chondrolon – after8 weeks. Both drugs provided functional improvement assessed by WOMAC index butChondrolon was more effective. Conclusion. Chondrolon and Zel T can be used for treatment of OA at I or II stage with moderate knee joints functional disability. Course of treatment with Zel T should be continued not less than 3 months and with Chondrolon – 2 months.

  3. Diversity of Streptococcus salivarius ptsH Mutants That Can Be Isolated in the Presence of 2-Deoxyglucose and Galactose and Characterization of Two Mutants Synthesizing Reduced Levels of HPr, a Phosphocarrier of the Phosphoenolpyruvate:Sugar Phosphotransferase System

    Science.gov (United States)

    Thomas, Suzanne; Brochu, Denis; Vadeboncoeur, Christian

    2001-01-01

    In streptococci, HPr, a phosphocarrier of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS), undergoes multiple posttranslational chemical modifications resulting in the formation of HPr(His∼P), HPr(Ser-P), and HPr(Ser-P)(His∼P), whose cellular concentrations vary with growth conditions. Distinct physiological functions are associated with specific forms of HPr. We do not know, however, the cellular thresholds below which these forms become unable to fulfill their functions and to what extent modifications in the cellular concentrations of the different forms of HPr modify cellular physiology. In this study, we present a glimpse of the diversity of Streptococcus salivarius ptsH mutants that can be isolated by positive selection on a solid medium containing 2-deoxyglucose and galactose and identify 13 amino acids that are essential for HPr to properly accomplish its physiological functions. We also report the characterization of two S. salivarius mutants that produced approximately two- and threefoldless HPr and enzyme I (EI) respectively. The data indicated that (i) a reduction in the synthesis of HPr due to a mutation in the Shine-Dalgarno sequence of ptsH reduced ptsI expression; (ii) a threefold reduction in EI and HPr cellular levels did not affect PTS transport capacity; (iii) a twofold reduction in HPr synthesis was sufficient to reduce the rate at which cells metabolized PTS sugars, increase generation times on PTS sugars and to a lesser extent on non-PTS sugars, and impede the exclusion of non-PTS sugars by PTS sugars; (iv) a threefold reduction in HPr synthesis caused a strong derepression of the genes coding for α-galactosidase, β-galactosidase, and galactokinase when the cells were grown at the expense of a PTS sugar but did not affect the synthesis of α-galactosidase when cells were grown at the expense of lactose, a noninducing non-PTS sugar; and (v) no correlation was found between the magnitude of enzyme derepression and

  4. Application of probabilistic fracture mechanics to the PTS issue

    International Nuclear Information System (INIS)

    As a part of the NRC effort to obtain a resolution to the PWR PTS issue, a probabilistic approach has been applied that includes a probabilistic fracture-mechanics (PFM) analysis. The PFM analysis is performed with OCA-P, a computer code that performs thermal, stress and fracture-mechanics analyses and estimates the conditional probability of vessel failure, P(F/E), using Monte Carlo techniques. The stress intensity factor (K/sub I/) is calculated for two- and three-dimensional surface flaws using superposition techniques and influence coefficients. Importance-sampling techniques are used, as necessary, to limit to a reasonable value the number of vessels actually calculated. Analyses of three PWR plants indicate that (1) the critical initial flaw depth is very small (5 to 15 mm), (2) the benefit of warm prestressing and the role of crack arrest are transient dependent, (3) crack arrest does not occur for the dominant transients, and (4) the single largest uncertainty in the overall probabilistic analysis is the number of surface flaws per vessel. 30 refs., 6 figs., 4 tabs

  5. PredPlantPTS1: a web server for the prediction of plant peroxisomal proteins

    Directory of Open Access Journals (Sweden)

    Sigrun eReumann

    2012-08-01

    Full Text Available Prediction of subcellular protein localization is essential to correctly assign unknown proteins to cell organelle-specific protein networks and to ultimately determine protein function. For metazoa, several computational approaches have been developed in the past decade to predict peroxisomal proteins carrying the peroxisome targeting signal type 1 (PTS1. However, plant-specific PTS1 protein prediction methods have been lacking up to now, and pre-existing methods generally were incapable of correctly predicting low-abundance plant proteins possessing non-canonical PTS1 patterns. Recently, we presented a machine learning approach that is able to predict PTS1 proteins for higher plants (spermatophytes with high accuracy and which can correctly identify unknown targeting patterns, i.e. novel PTS1 tripeptides and tripeptide residues. Here we describe the first plant-specific web server PredPlantPTS1 for the prediction of plant PTS1 proteins using the above-mentioned underlying models. The server allows the submission of protein sequences from diverse spermatophytes and also performs well for mosses and algae. The easy-to-use web interface provides detailed output in terms of (i the peroxisomal targeting probability of the given sequence, (ii information whether a particular non-canonical PTS1 tripeptide has already been experimentally verified, and (iii the prediction scores for the single C-terminal 14 amino acid residues. The latter allows identification of predicted residues that inhibit peroxisome targeting and which can be optimized using site-directed mutagenesis to raise the peroxisome targeting efficiency. The prediction server will be instrumental in identifying low-abundance and stress-inducible peroxisomal proteins and defining the entire peroxisomal proteome of Arabidopsis and agronomically important crop plants. PredPlantPTS1 is freely accessible at ppp.gobics.de.

  6. The relevance of the non-canonical PTS1 of peroxisomal catalase

    OpenAIRE

    Williams, Chris; Aksam, Eda Bener; Gunkel, Katja; Veenhuis, Marten; van der Klei, Ida J.

    2012-01-01

    Catalase is sorted to peroxisomes via a C-terminal peroxisomal targeting signal 1 (PTS1), which binds to the receptor protein Pex5. Analysis of the C-terminal sequences of peroxisomal catalases from various species indicated that catalase never contains the typical C-terminal PTS1 tripeptide-SKL, but invariably is sorted to peroxisomes via a non-canonical sorting sequence. We analyzed the relevance of the non-canonical PTS1 of catalase of the yeast Hansenula polymorpha (-SKI). Using isotherma...

  7. PAPR Reduction of OFDM Signals by Novel Global Harmony Search in PTS Scheme

    Directory of Open Access Journals (Sweden)

    Hojjat Salehinejad

    2012-01-01

    Full Text Available The orthogonal frequency division multiplexing (OFDM modulation technique is one of the key strategies for multiuser signal transmission especially in smart grids and wind farms. This paper introduces an approach for peak-to-average power ratio (PAPR reduction of such signals based on novel global harmony search (NGHS and partial transmit sequence (PTS schemes. In PTS technique, the data block to be transmitted is partitioned into disjoint subblocks, which are combined using phase factors to minimize PAPR. The PTS requires an exhaustive search over all combinations of allowed phase factors. Therefore, with respect to the fast implementation and simplicity of NGHS technique, we could achieve significant reduction of PAPR.

  8. Spine inflammatory changes in patients with ankylosing spondylitis assessed by magnetic resonance image

    Directory of Open Access Journals (Sweden)

    A G Bochkova

    2008-01-01

    Full Text Available Objective. To develop the optimal mode of spine evaluation with magnetic resonance image (MRl in pts with ankylosing spondylitis (AS and to study relationship between MR! signs of spinal inflammatory lesions (IL, spondylitis duration and clinical features of AS activity. Material and methods. MRl was performed in 36 pts (22 male, 14 female fulfilling the modified NY criteria of AS. Median age of pis was 26 years (range 19 - 55, Median AS duration - 8 years (range 1,8 - 24. 34 (97% pts were HLA-B27 positive. 21 (64% pts had high AS activity - median BASDAI 40 (range 10 - 77. 92% of pts had inflammatory spine pain (VAS>20 mm and 61% of pts had night pain. Median inflammatory pain duration had been defined separately for every part of the spine assessed by MRl. Median duration of axial pain was 36 months (range: 1-240. MR-scanning (Magnetom Symphony, Siemens, 1.5 T was performed inTl, T2 and T2-FS (fat signal suppression modes. IL scoring was done only in 29 pts evaluated in both sagittal and axial planes. We used two scoring methods: 1 individual IL score of the each spine element (vertebral bodies, processes, arches, zygapophyseai, costovertebral and costotransverse joints, ligaments, and 2 separate IL scoring in the vertebral bodies and posterior spinal elements in order "yes/no”. Results. 50 MRl images of different parts of the spine (8 cervical, 30 thoracic and 12 lumbar have been obtained in 36 pts. Spine IL were found in 35 pts. 26% of all IL were revealed in axial planes. 3 pts with short AS duration had IL only on axial slices (zygapophyseai lumbar joints, costotransverse joints, processes. IL were revealed more often in thoracic (average score: 7.1, than in lumbar (3.7 and cervical (2.1 spine. In most (26 from 29 pts, 90% pts IL were found in painful parts of spine. There was no IL score difference between pts(n=12 with low (BASDAI <40 and high (BASDAI>40; n=17 AS activity. Me and range were 4 (1.8-10.3 and 6 (4-16, respectively; p=0

  9. PTS phosphorylation of Mga modulates regulon expression and virulence in the group A streptococcus.

    Science.gov (United States)

    Hondorp, Elise R; Hou, Sherry C; Hause, Lara L; Gera, Kanika; Lee, Ching-En; McIver, Kevin S

    2013-06-01

    The ability of a bacterial pathogen to monitor available carbon sources in host tissues provides a clear fitness advantage. In the group A streptococcus (GAS), the virulence regulator Mga contains homology to phosphotransferase system (PTS) regulatory domains (PRDs) found in sugar operon regulators. Here we show that Mga was phosphorylated in vitro by the PTS components EI/HPr at conserved PRD histidines. A ΔptsI (EI-deficient) GAS mutant exhibited decreased Mga activity. However, PTS-mediated phosphorylation inhibited Mga-dependent transcription of emm in vitro. Using alanine (unphosphorylated) and aspartate (phosphomimetic) mutations of PRD histidines, we establish that a doubly phosphorylated PRD1 phosphomimetic (D/DMga4) is completely inactive in vivo, shutting down expression of the Mga regulon. Although D/DMga4 is still able to bind DNA in vitro, homo-multimerization of Mga is disrupted and the protein is unable to activate transcription. PTS-mediated regulation of Mga activity appears to be important for pathogenesis, as bacteria expressing either non-phosphorylated (A/A) or phosphomimetic (D/D) PRD1 Mga mutants were attenuated in a model of GAS invasive skin disease. Thus, PTS-mediated phosphorylation of Mga may allow the bacteria to modulate virulence gene expression in response to carbohydrate status. Furthermore, PRD-containing virulence regulators (PCVRs) appear to be widespread in Gram-positive pathogens. PMID:23651410

  10. Shear-wave elastography contributes to accurate tumour size estimation when assessing small breast cancers

    International Nuclear Information System (INIS)

    Aim: To assess whether the size of peritumoural stiffness (PTS) on shear-wave elastography (SWE) for small primary breast cancers (≤15 mm) was associated with size discrepancies between grey-scale ultrasound (GSUS) and final histological size and whether the addition of PTS size to GSUS size might result in more accurate tumour size estimation when compared to final histological size. Materials and methods: A retrospective analysis of 86 consecutive patients between August 2011 and February 2013 who underwent breast-conserving surgery for tumours of size ≤15 mm at ultrasound was carried out. The size of PTS stiffness was compared to mean GSUS size, mean histological size, and the extent of size discrepancy between GSUS and histology. PTS size and GSUS were combined and compared to the final histological size. Results: PTS of >3 mm was associated with a larger mean final histological size (16 versus 11.3 mm, p < 0.001). PTS size of >3 mm was associated with a higher frequency of underestimation of final histological size by GSUS of >5 mm (63% versus 18%, p < 0.001). The combination of PTS and GSUS size led to accurate estimation of the final histological size (p = 0.03). The size of PTS was not associated with margin involvement (p = 0.27). Conclusion: PTS extending beyond 3 mm from the grey-scale abnormality is significantly associated with underestimation of tumour size of >5 mm for small invasive breast cancers. Taking into account the size of PTS also led to accurate estimation of the final histological size. Further studies are required to assess the relationship of the extent of SWE stiffness and margin status. - Highlights: • Peritumoural stiffness of greater than 3 mm was associated with larger tumour size. • Underestimation of tumour size by ultrasound was associated with peri-tumoural stiffness size. • Combining peri-tumoural stiffness size to ultrasound produced accurate tumour size estimation

  11. Functional characterization of the incomplete phosphotransferase system (PTS of the intracellular pathogen Brucella melitensis.

    Directory of Open Access Journals (Sweden)

    Marie Dozot

    Full Text Available BACKGROUND: In many bacteria, the phosphotransferase system (PTS is a key player in the regulation of the assimilation of alternative carbon sources notably through catabolic repression. The intracellular pathogens Brucella spp. possess four PTS proteins (EINtr, NPr, EIIANtr and an EIIA of the mannose family but no PTS permease suggesting that this PTS might serve only regulatory functions. METHODOLOGY/PRINCIPAL FINDINGS: In vitro biochemical analyses and in vivo detection of two forms of EIIANtr (phosphorylated or not established that the four PTS proteins of Brucella melitensis form a functional phosphorelay. Moreover, in vitro the protein kinase HprK/P phosphorylates NPr on a conserved serine residue, providing an additional level of regulation to the B. melitensis PTS. This kinase activity was inhibited by inorganic phosphate and stimulated by fructose-1,6 bisphosphate. The genes encoding HprK/P, an EIIAMan-like protein and NPr are clustered in a locus conserved among α-proteobacteria and also contain the genes for the crucial two-component system BvrR-BvrS. RT-PCR revealed a transcriptional link between these genes suggesting an interaction between PTS and BvrR-BvrS. Mutations leading to the inactivation of EINtr or NPr significantly lowered the synthesis of VirB proteins, which form a type IV secretion system. These two mutants also exhibit a small colony phenotype on solid media. Finally, interaction partners of PTS proteins were identified using a yeast two hybrid screen against the whole B. melitensis ORFeome. Both NPr and HprK/P were shown to interact with an inorganic pyrophosphatase and the EIIAMan-like protein with the E1 component (SucA of 2-oxoglutarate dehydrogenase. CONCLUSIONS/SIGNIFICANCE: The B. melitensis can transfer the phosphoryl group from PEP to the EIIAs and a link between the PTS and the virulence of this organism could be established. Based on the protein interaction data a preliminary model is proposed in which

  12. Two-phase CFD PTS validation in an extended range of thermohydraulics conditions covered by the COSI experiment

    International Nuclear Information System (INIS)

    Highlights: • Models for large interfaces in two-phase CFD were developed for PTS. • The COSI experiment is used for NEPTUNECFD integral validation. • COSI is a PWR cold leg scaled 1/100 for volume. • Fifty runs are calculated, covering a large range of flow configurations. • The CFD predicting capability is analysed using global and local measurements. - Abstract: In the context of the Pressurized Water Reactors (PWR) life duration safety studies, some models were developed to address the Pressurized Thermal Shock (PTS) from the two-phase CFD angle, dealing with interfaces much larger than cells size and with direct contact condensation. Such models were implemented in NEPTUNECFD, a 3D transient Eulerian two-fluid model. The COSI experiment is used for its integral validation. It represents a cold leg scaled 1/100 for volume and power from a 900 MW PWR under a large range of LOCA PTS conditions. In this study, the CFD is evaluated in the whole range of parameters and flow configurations covered by the experiment. In a first step, a single choice of mesh and CFD models parameters is fixed and justified. In a second step, fifty runs are calculated. The CFD predicting capability is analysed, comparing the liquid temperature and the total condensation rate with the experiment, discussing their dependency on the inlet cold liquid rate, on the liquid level in the cold leg and on the difference between co-current and counter-current runs. It is shown that NEPTUNECFD 1.0.8 calculates with a fair agreement a large range of flow configurations related to ECCS injection and steam condensation

  13. Further experimental verification of warm prestressing effect under pressurized thermal shock (PTS)

    International Nuclear Information System (INIS)

    Fracture tests for the verification of WPS (warm prestressing) effect were carried out by using large flat specimens with very low toughness. Tensile and bending loads and thermal shock were applied simultaneously to the specimens with the realistically postulated flaw and the two times larger one in order to make the maximum KI cross the lower bound of KIC data. During the tests, loading was controlled to simulate the shape of KI versus temperature curve for the postulated PTS transient. Both the specimens did not break within the scatter band of KIC when KI was decreased during cooling. KI values at fracture by reloading were beyond the upper bound of KIC. That is, the effectiveness of WPS was directly demonstrated for the PTS transients. Also, KI values at fracture can be predicted by Chell's theory. As the test results, Japanese PWRs have sufficient temperature margin against PTS

  14. The Performance Analysis of PAPR Reduction using a novel PTS technique in OFDM-MIMO System

    Directory of Open Access Journals (Sweden)

    Kashish Sareen

    2012-08-01

    Full Text Available Orthogonal Frequency Division Multiplexing (OFDM is an new multiplexing technique for 4G and 4.5G generation wireless communication. MIMO-OFDM is latest multiplexing technique which is resposible for high performance 4G broadband wireless communications. But there is one main disadvantage of MIMO-OFDM is the high peak-to-average power ratio (PAPR of the transmitter’s output signal on different antennas. In this paper, we present a new noble (PTS Partial transmit sequence technique to reduce PAPR problem in OFDM-MIMO system. This new PTS technique gives us better PAPR Reduction gain in OFDM-MIMO as compared with original and another PTS Techniques.

  15. PAPR Reduction Using BPSO/PTS and STBC in MIMO OFDM System

    Directory of Open Access Journals (Sweden)

    Karima El Mouhib

    2011-01-01

    Full Text Available Problem statement: The Multiple Input Multiple Output (MIMO Orthogonal Frequency Division Multiplexing (OFDM system has been receiving a great attention, as one of solutions for achieving high speed, efficient and high-quality service for the wireless communications. However, the transmitted signal still has high PAPR because of OFDM characteristics. Many methods have been proposed to solve this problem, but the most of them decrease high Peak-to-Average Power Ratio (PAPR as well as the data rate. Approach: This proposal described a new suboptimal technique for reduction of the PAPR by combining two suitable methods for MIMO OFDM systems. The first method was based on Boolean Particle Swarm intelligence Optimization (BPSO applied to Partial transmit Sequence (PTS and the second was the Space Time Bloc Coding (STBC. Result: Apply only the PTS technique and independently on each transmitted antenna, was effective to reduce PAPR, but it requires high computation complexity. Therefore, the BPSO/PTS technique provided better performance and it was been promoted as an uncomplicated way for PAPR reduction. Thanks of the BPSO/PTS algorithm; the transmitted sequence was selected with minimizing the maximum PAPR over all transmission antennas. The simulations and the BER performance demonstrated that more inertia weight and phase weighting factor obtained better PAPR reduction performance without bringing much higher complexity. Conclusion: Results show that the added BPSO/PTS method to orthogonal space time bloc coding minimizes computational complexity cost as well as the PAPR and gives best optimal PTS performance in comparison with the conventional methods.

  16. PTS-TR方法降低CO-OFDM系统的PAPR%PTS-TR Method For PAPR Reduction In Coherent Optical OFDM Systems

    Institute of Scientific and Technical Information of China (English)

    司亚楠; 陈鹏

    2012-01-01

    In coherent optical OFDM system, the signal having a larger PAPR wall produce a serious distortion, and greatly reduce the efficiency of the system. In order to contain the PAPR in coherent optical OFDM system, a new method of PTS-TR is presented. The simulation results show that compared with the traditional TR or PTS method,the effect of the new method has greater stability and smaller computational complexity, it has a better performance of PAPR reduction, and is more suitable for coherent optical OFDM system.%在相干光正交频分复用(CO-OFDM)系统中,较高的峰均功率比会使信号产生严重的畸变,导致系统误码率性能的严重下降,为了抑制CO-OFDM系统的PAPR提出了一种PTS-TR方法.仿真结果表明,该方法与传统TR方法和PTS方法相比,具有很高的稳定性和更小的运算复杂度,对PAPR的抑制性能较好,更适用于CO-OFDM系统.

  17. Crack growth prediction analyses of a RPV prototype under PTS loading

    International Nuclear Information System (INIS)

    This work presents the numerical finite element analysis and fracture mechanics procedure carried out to predict crack growth behavior of a reactor pressure vessel (RPV) prototype during a pressurized thermal shock (PTS) experiment. A brief description of the PTS experiment is given, followed by a presentation of the numerical models used for thermal structural analysis and to obtain the crack driving force parameters. Fracture mechanics procedures, with different levels of complexity, are presented for crack growth prediction. The results obtained using a simplified procedure are compared with those based on 3D finite element analyses. (author)

  18. Evaluation of a portable test system for assessing endotoxin activity in raw milk.

    Science.gov (United States)

    Suzuki, Yohko; Suzuki, Kazuyuki; Shimamori, Toshio; Tsuchiya, Masakazu; Niehaus, Andrew; Lakritz, Jeffrey

    2016-01-01

    The aim of the present study was to compare endotoxin activities detected in raw milk samples obtained from cattle by a commercially available portable test system (PTS) and traditional microplate limulus amebocyte lysate (LAL)-based assay, which determined activities using a kinetic turbidimetric (KT) assay. Raw milk samples were obtained from 53 and 12 dairy cattle without and with clinical mastitis, respectively. Comparison between the KT and PTS was performed by the Friedman test. The Pearson product moment correlation coefficients were calculated to evaluate associations between any two continuous variables. Linear regression model analysis was also performed to obtain the equation describing the relationship between PTS and KT assay. The endotoxin activities detected in 200- or 400-fold diluted milk samples were similar between PTS and KT assay, whereas a significant difference was observed in 100-fold diluted milk (Pmastitis cows were 0.655 and 11,523.5 EU/ml, respectively. The results of the present study suggest that PTS as a simple and easy test to assess endotoxin activity in raw milk is efficient, simple and reproducible. PMID:26279135

  19. Service framework for Internet of People, Things and Services (IoPTS)

    DEFF Research Database (Denmark)

    Shinde, Gitanjali; Olesen, Henning

    2016-01-01

    the literature work,a detaileddiscussionon the requirements, functionalities and need of the user-centric service frameworkthat is needed to realize IoPTS is presented in this work.We propose amodified Bluetooth Low Energy (BLE) beacon to advertise the services present at a particular location in the view...

  20. Validation of the Large Interface Method of NEPTUNE{sub C}FD 1.0.8 for Pressurized Thermal Shock (PTS) applications

    Energy Technology Data Exchange (ETDEWEB)

    Coste, P., E-mail: pierre.coste@cea.fr [CEA, DEN, DER/SSTH, F-38054 Grenoble (France); Lavieville, J. [Electricite de France, Chatou (France); Pouvreau, J. [CEA, DEN, DER/SSTH, F-38054 Grenoble (France); Baudry, C.; Guingo, M.; Douce, A. [Electricite de France, Chatou (France)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer The two-phase Pressurized Thermal Shock (PTS) is a key thermohydraulics issue for PWR safety. Black-Right-Pointing-Pointer The dynamic and condensation models are firstly validated separately. Black-Right-Pointing-Pointer Then the global validation is done with the COSI experiment. Black-Right-Pointing-Pointer All the calculations performed with the same set of models both in the Large Interface Method and in the k-{epsilon} approach for turbulence substantiate the application of the tool to PTS. - Abstract: NEPTUNE{sub C}FD is a code based on a 3D transient Eulerian two-fluid model. One of the main application targets is the two-phase Pressurized Thermal Shock (PTS), which is related to PWR Reactor Pressure Vessel (RPV) lifetime safety studies, when sub-cooled water from Emergency Core Cooling (ECC) system is injected into the possibly uncovered cold leg and penetrates into the RPV downcomer. Five experiments were selected for the validation, a selection reviewed by a panel of European experts. The dynamic models are validated with a co-current smooth and wavy air-water stratified flow in a rectangular channel with detailed measurements of turbulence and velocities. The condensation models are validated with a co-current smooth and wavy steam-water stratified flow in a rectangular channel with measurements of the steam flow rates. The dynamic models are validated in the situation of a jet impinging a pool free surface with two experiments dealing with a water jet impingement on a water pool free surface in air environment. Finally, all the models involved in the reactor conditions are validated with the COSI experiment. The calculations are done with the same set of Large Interface Method models and a RANS (k-{epsilon}) approach for turbulence. They substantiate the application of the tool to PTS studies.

  1. Construction of Listeria monocytogenes mutants with in-frame deletions in the phosphotransferase transport system (PTS) and analysis of their growth under stress conditions.

    Science.gov (United States)

    Liu, Yanhong; Ceruso, Marina; Jiang, Yuji; Datta, Atin R; Carter, Laurenda; Strain, Errol; Pepe, Tiziana; Anastasi, Aniello; Fratamico, Pina

    2013-09-01

    Listeria monocytogenes is a foodborne pathogen that is difficult to eliminate due to its ability to survive under different stress conditions such as low pH and high salt. To better control this pathogen in food, it is important to understand its survival mechanisms under these stress conditions. LMOf2365_0442, 0443, and 0444 encode for phosphotransferase transport system (PTS) permease (fructose-specific IIABC components) that is responsible for sugar transport. LMOf2365_0445 encodes for glycosyl hydrolase. These genes were induced by high pressure and inhibited under salt treatments; therefore, we hypothesized that genes encoding these PTS proteins may be involved in general stress responses. To study the function of these genes, deletion mutants of the PTS genes (LMOf2365_0442, LMOf2365_0443, and LMOf2365_0444) and the downstream gene LMOf2365_0445 were created in L. monocytogenes strain F2365. These deletion mutants were tested under different stress conditions. The growth of ∆LMOf2365_0445 was increased under nisin (125 μg/mL) treatments compared to the wild-type (P salt (brain-heart infusion medium with 5% NaCl) was significantly increased (P monocytogenes. An understanding of the growth of these mutants under multiple stress conditions may assist in the development of intervention strategies to control L. monocytogenes in food. PMID:23909479

  2. A ptsP deficiency in PGPR Pseudomonas fluorescens SF39a affects bacteriocin production and bacterial fitness in the wheat rhizosphere.

    Science.gov (United States)

    Godino, Agustina; Príncipe, Analía; Fischer, Sonia

    2016-04-01

    Pseudomonas fluorescens SF39a is a plant-growth-promoting bacterium isolated from wheat rhizosphere. In this report, we demonstrate that this native strain secretes bacteriocins that inhibit growth of phytopathogenic strains of the genera Pseudomonas and Xanthomonas. An S-type pyocin gene was detected in the genome of strain SF39a and named pys. A non-polar pys::Km mutant was constructed. The bacteriocin production was impaired in this mutant. To identify genes involved in bacteriocin regulation, random transposon mutagenesis was carried out. A miniTn5Km1 mutant, called P. fluorescens SF39a-451, showed strongly reduced bacteriocin production. This phenotype was caused by inactivation of the ptsP gene which encodes a phosphoenolpyruvate phosphotransferase (EI(Ntr)) of the nitrogen-related phosphotransferase system (PTS(Ntr)). In addition, this mutant showed a decrease in biofilm formation and protease production, and an increase in surface motility and pyoverdine production compared with the wild-type strain. Moreover, we investigated the ability of strain SF39a-451 to colonize the wheat rhizosphere under greenhouse conditions. Interestingly, the mutant was less competitive than the wild-type strain in the rhizosphere. To our knowledge, this study provides the first evidence of both the relevance of the ptsP gene in bacteriocin production and functional characterization of a pyocin S in P. fluorescens. PMID:26708985

  3. An evaluation of analysis methodologies for predicting cleavage arrest of a deep crack in an RPV subjected to PTS loading conditions

    International Nuclear Information System (INIS)

    Several calculational procedures are compared for predicting cleavage arrest of a deep crack in the wall of a prototypical reactor pressure vessel (RPV) subjected to pressurized-thermal-shock (PTS) types of loading conditions. Three procedures examined in this study utilized the following models: (1) a static finite-element model (full bending); (2) a radially constrained static model; and (3) a thermoelastic dynamic finite-element model. A PTS transient loading condition was selected that produced a deep arrest of an axially-oriented initially shallow crack according to calculational results obtained from the static (full-bending) model. Results from the two static models were compared with those generated from the detailed thermoelastic dynamic finite-element analysis. The dynamic analyses modeled cleavage-crack propagation using node-release technique and an application-mode methodology based on dynamic fracture toughness curves generated from measured data. Comparisons presented here indicate that the degree to which dynamic solutions can be approximated by static models is highly dependent on several factors, including the material dynamic fracture curves and the propensity for cleavage reinitiation of the arrested crack under PTS loading conditions. Additional work is required to develop and validate a satisfactory dynamic fracture toughness model applicable to postcleavage arrest conditions in an RPV

  4. Synbiotic impact of tagatose on viability of Lactobacillus rhamnosus strain GG mediated by the phosphotransferase system (PTS).

    Science.gov (United States)

    Koh, Ji Hoon; Choi, Seung Hye; Park, Seung Won; Choi, Nag-Jin; Kim, Younghoon; Kim, Sae Hun

    2013-10-01

    Synbiotics, the combination of prebiotics and probiotics, has been shown to produce synergistic effects that promote gastrointestinal well-being of host. Tagatose is a low calorie food ingredient with putative health-promoting benefits. Herein, we investigated its synbiotic impact on the viability of Lactobacillus casei 01 and Lactobacillus rhamnosus strain GG and the potential mechanism involved. Tagatose, as a synbiotic substrate, enhanced the growth of L. casei 01 and L. rhamnosus strain GG compared to other prebiotics. Other gut-indigenous such as Clostridium spp. readily utilized fructooligosaccharide (FOS), the most widely used functional prebiotics, but not tagatose. Additionally, tagatose enhanced probiotic functions of L. casei 01 and L. rhamnosus strain GG by reinforcing their attachment on HT-29 intestine epithelial cells and enhancing their cholesterol-lowering activities. Whole transcriptome study and quantitative real-time polymerase chain reaction (qRT-PCR) test showed that the presence of tagatose in L. rhamnosus strain GG caused induction of a large number of genes associated with carbohydrate metabolism including the phosphotransferase system (PTS). Collectively, these results indicate the tagatose enhanced the growth of L. casei 01 and L. rhamnosus strain GG and their probiotic activities by activating tagatose-associated PTS networks. Importantly, this study highlights the potential application of tagatose and L. casei 01 and/or L. rhamnosus strain GG as a synbiotic partner in functional dairy foods (i.e. yogurt and cheese) and therapeutic dietary supplements. PMID:23764214

  5. Numerical simulations of the TOPFLOW-PTS steam-water experiment

    International Nuclear Information System (INIS)

    The correct analysis of the Pressurized Thermal Shock requires the simulation of the thermal mixing that occurs when cold Emergency Core Cooling (ECC) water is injected into the cold leg, where it flows to the downcomer and mixes with the hot coolant present in the primary circuit. In the framework of the NURISP (NUclear Reactor Integrated Simulation Project) project attempts are being made to improve the CFD modeling for two-phase PTS scenarios. For this purpose, two steady-state reference cases from the TOPFLOW-PTS experimental program were defined: one for air-water and one for steam-water flow. The current paper focuses only on the steam-water reference case. The pre-test simulations were performed with the commercial CFD code ANSYS CFX 12.0. The simulations of the steam-water reference test predicted a thermal stratification in the cold leg at the entrance into the downcomer and in the downcomer itself. (author)

  6. Low-Complexity SLM and PTS Schemes for PAPR Reduction in OFDM Systems

    Science.gov (United States)

    Wang, Chin-Liang; Ouyang, Yuan; Hsu, Ming-Yen

    One major drawback of orthogonal frequency-division multiplexing is the high peak-to-average power ratio (PAPR) of the output signal. The selected mapping (SLM) and partial transmit sequences (PTS) methods are two promising techniques for PAPR reduction. However, to generate a set of candidate signals, these techniques need a bank of inverse fast Fourier transforms (IFFT's) and thus require high computational complexity. In this paper, we propose two low-complexity multiplication-free conversion processes to replace the IFFT's in the SLM method, where each conversion process for an N-point IFFT involves only 3N complex additions. Using these proposed conversions, we develop several new SLM schemes and a combined SLM & PTS method, in which at least half of the IFFT blocks are reduced. Computer simulation results show that, compared to the conventional methods, these new schemes have approximately the same PAPR reduction performance under the same number of candidate signals for transmission selection.

  7. Accumulation of chlorinated and brominated persistent toxic substances (PTS) and their relationship to testosterone suppression in Norway rats from Japan

    Energy Technology Data Exchange (ETDEWEB)

    Takasuga, T.; Senthilkumar, K. [Shimadzu Techno-Research Inc. (Japan); Ishizuka, M.; Fujita, S. [Graduate School of Veterinary Medicine, Hokkaido Univ. (Japan); Tanikawa, R. [Inst. of Tech., Ikari Corp. (Japan)

    2004-09-15

    Contamination of chlorinated/brominated persistent toxic substances (PTS) such as polychlorinated, -dibenzo-p-dioxins (PCDDs), -dibenzofurans (PCDFs), -biphenyls (PCBs), - organochlorine pesticides (OCPs) {l_brace}e.g., aldrin, dieldrin, endrin, chlordane compounds [cis/transchlordane, cis/trans-nonachlor, oxychlordane, heptachlor, heptachlor epoxide], hexachlorobenzene (HCB), 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDTs) and its metabolities [o,p/p,p'-DDD and DDE] and hexachlorocyclohexane (HCHs){r_brace} and -brominated diphenyl ethers (PBDEs) are considered to important class of chemicals due to persistence in nature, bioaccumulation potential and adverse health effects in wildlife and humans. Among South East Asian countries, Japan reported to contaminated with aforesaid chemicals with considerable amounts. There is no document reports contamination of PTS in wild animals, which in-habit near humans. Norway rat (NR) inhabits not only near human environment but also distributed worldwide. Especially, NR feeds on human waste and shelter in and around human environment and thus exposure of toxic contaminants in this animal considered to similar with those in humans. In addition, rats have unique physiology that match with humans (e.g., they have similar pathogens as humans have). Therefore, analysis of toxic contaminants in NR considered as indirect measure in humans. Considering those facts, in this study, we analyzed NR collected from urban area, rural area, waste dumping or land fill site and isolated remote island from Japan. Particularly several chlorinated and brominated organic contaminants such as PCDDs, PCDFs, PCBs, DDTs, HCHs, chlordane compounds, heptachlor, heptachlor epoxide, HCB, aldrin, dieldrin, endrin and PBDEs were analyzed in rat livers by isotope dilution technique using HRGC-HRMS. In addition, laboratory Wistar rats (WR) were used as control.

  8. Thermal hydraulic analyses of NPPs with VVER-440/213 for the PTS condition evaluation

    International Nuclear Information System (INIS)

    The paper presents the Nuclear Research Institute (NRI) Rez approach to selection of accident scenarios with risk of pressurized thermal shock (PTS) on reactor pressure vessel (RPV) and, therefore, loss of the RPV integrity. Some thermal hydraulic analyses of the phenomenon performed so far are described and main results are shown. Suitability of different types of thermal hydraulic computer codes to such analyses is discussed. Planned activities are also presented. Attention is focused to thermal hydraulics; problems of fracture mechanic analyses which naturally follow the thermal hydraulic analyses and give the final answer to the question of severity of given accident from the point of view of PTS are not treated in this paper. Identification of accident scenarios involving a risk of PTS is the first step of the PTS thermal-hydraulic and fracture mechanic analyses. The paper contains a discussion of such scenarios for NPPs with VVER-440/213 reactors. Attention is paid mainly to secondary circuit leakages. As an example, one accident scenario (main steam header rupture with multiple steamline break) is analysed by means of RELAP5 code, then the reactor downcomer and lower plenum are analysed by means of the CATHARE 2 vl.3 two-dimensional module, and, finally, velocity and temperature fields in one cold leg and a part of the reactor downcomer are calculated by means of 3-D thermal-hydraulic code FLUTAN 2 for 50 seconds after start of HPIS pumps and the case of primary coolant stagnation. Time dependent development of a cold plume in the calculational region is shown at various cross-sections. (author)

  9. Audit and Assessment Studies

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Craig [Tlingit-Haida Regional Housing Authority, Juneau, AK (United States)

    2016-03-22

    Project to assess 46 low-income multifamily residences owned and managed by THRHA in up to 14 southeast Alaska communities. The Objective of project was to identify efficiency measures to reduce energy costs by 30% for low-income multifamily housing by; 1. Decreasing energy demand by increasing multifamily housing energy efficiency; 2. Reducing household energy consumption through energy conservation education and installation of energy upgrades; and 3. Projecting energy savings based on fossil fuel reduction to environmentally and economically benefit Tribal southeast communities

  10. Remodeling and Characterization of Pneumatic Transfer System (PTS no.3) of HANARO Research Reactor for Neutron Activation Analysis

    International Nuclear Information System (INIS)

    A pneumatic transfer system (PTS) is one of the facilities to be used in an irradiation of a target material for an instrumental neutron activation analysis (INAA) in a research reactor. This technical report describes for the irradiation test and the characteristics and removing, remodelling of the reinstalled PTS no.3 in NAA no.3 irradiation hole at HANARO for user information and the reactor management

  11. TOPFLOW-PTS air-water experiments on the phase separation in the ECC nozzle and the ECC water mixing during PTS scenarios

    International Nuclear Information System (INIS)

    In two-phase Pressurized Thermal Shock scenarios several thermal hydraulic phenomena, such as direct contact condensation, entrainment of steam bubbles and multi-scale momentum transfer are involved. The TOPFLOW-PTS experimental assembly represents a 1:2.5 scaled model of a PWR downcomer, cold leg with emergency core cooling injection and a pump simulator. It is build up for the development and validation of CFD models. The setup is highly instrumented - a large number of thermocouples, an infrared and a high-speed camera as well as wire mesh sensors are used to obtain CFD-grade data. As a first step air-water experiments were done with the special aim to investigate the behaviour of the liquid jet from the ECC injection into the cold leg. They indicated that the jet momentum at the impact position is very important for the mixing process and stratification inside the ECC nozzle needs to be considered in CFD calculations. (author)

  12. Pre-operative Concomitant Radio-chemotherapy in Bulky Carcinoma of the Cervix: A Single Institution Study

    Directory of Open Access Journals (Sweden)

    Anne de la Rochefordiere

    2008-01-01

    Full Text Available Objective: To evaluate the treatment results of patients (pts with FIGO stage IB2, IIA, IIB cervical carcinoma (CC treated with pre-operative radio-chemotherapy, followed by extended radical hysterectomy.Methods: Retrospective study of 148 women treated to the Institut Curie for operable FIGO Stage IB2 to IIB, biopsy proved CC. Among them, 70 pts, median age 46 years, were treated using the same regimen associating primary radio-cisplatinum based chemotherapy, intracavitary LDR brachytherapy, followed by extended radical hysterectomy. Kaplan-Meier estimates were used to draw survival curves. Comparisons of survival distribution were assessed by the log-rank test. Results: Complete histological local-regional response was obtained in 56% of the pts (n = 39. Residual macroscopic or microscopic disease in the cervix was observed in 28 pts (40%. All but one had in-situ microscopic residual CC. Lateral residual disease in the parametria was also present in 9 pts, all with residual CC. Pelvic lymph nodes were free from microscopic disease in 56 pts (80%. Eight of 55 (11% radiological N0 patients had microscopic nodal involvement, as compared to 6/15 (40% radiological N1 (p = 0.03. Seventeen pts (25% had residual cervix disease but negative nodes. After median follow-up of 40 months (range, 8–141, 38/70 patients (54.1% are still alive and free of disease, 6 (8.6% alive with disease, and 11 (15.8% patients were lost for follow-up but free of disease.In conclusion: The treatment of locally advanced CC needs a new multidisciplinary diagnostic and treatment approach using new therapeutic arms to improve the survival and treatment tolerance among women presenting this disease.

  13. Effect of the dilution factor on 18FDG and Na18F samples for bacterial endotoxin test using PTS (portable test system)

    International Nuclear Information System (INIS)

    18FDG and Na18F are radiopharmaceuticals produced as sterile solutions suitable for intravenous administration, which must contain no more than 175 EV/V. The most commonly used approach to detect endotoxins is the gelclot technique that requires 60 minutes for results. For radiopharmaceuticals containing short-life radionuclides, such as 18F, there is an increasing interest for faster quality control methods. FDA licensed the Endosafe, PTS, a kinetic chromogenic endotoxin detection system that takes about 15 minutes for results. As other techniques, PTS test is susceptible to interferences which can be solved by product dilution. The aim of this study was to establish the best dilution of 18FDG and Na18F for PTS analysis. Two different dilution factors for 18FDG and 1:10 for Na18F were essayed: 1:10 and 1:100. 18FDG and Na18 solutions were prepared by the addition of LAL reagent water. Considering the assay acceptance criteria, the best dilution factor was 1:100 for 18FDG and 1:10 for Na18F. The recovery of the product positive control was 98-12% for 18FDG 1:100 and 104-120% for Na18F 1:10, which were, in both cases, within the specification (50-200%) and very close to 100%. Results obtained with these dilution studies were important to establish the most appropriate and non-interfering dilution factor for 18FDG and Na18F routine endotoxin test. (author)

  14. Effect of the dilution factor on {sup 18}FDG and Na{sup 18}F samples for bacterial endotoxin test using PTS (portable test system)

    Energy Technology Data Exchange (ETDEWEB)

    Silveira, Marina B.; Costa, Flavia M.; Ferreira, Soraya Z., E-mail: mbs@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil). Unidade de Pesquisa e Producao de Radiofarmacos

    2011-07-01

    {sup 18}FDG and Na{sup 18}F are radiopharmaceuticals produced as sterile solutions suitable for intravenous administration, which must contain no more than 175 EV/V. The most commonly used approach to detect endotoxins is the gelclot technique that requires 60 minutes for results. For radiopharmaceuticals containing short-life radionuclides, such as {sup 18}F, there is an increasing interest for faster quality control methods. FDA licensed the Endosafe, PTS, a kinetic chromogenic endotoxin detection system that takes about 15 minutes for results. As other techniques, PTS test is susceptible to interferences which can be solved by product dilution. The aim of this study was to establish the best dilution of {sup 18}FDG and Na{sup 18}F for PTS analysis. Two different dilution factors for {sup 18}FDG and 1:10 for Na{sup 18}F were essayed: 1:10 and 1:100. {sup 18}FDG and Na{sup 18} solutions were prepared by the addition of LAL reagent water. Considering the assay acceptance criteria, the best dilution factor was 1:100 for {sup 18}FDG and 1:10 for Na{sup 18}F. The recovery of the product positive control was 98-12% for {sup 18}FDG 1:100 and 104-120% for Na{sup 18}F 1:10, which were, in both cases, within the specification (50-200%) and very close to 100%. Results obtained with these dilution studies were important to establish the most appropriate and non-interfering dilution factor for {sup 18}FDG and Na{sup 18}F routine endotoxin test. (author)

  15. The Performance Analysis of PAPR Reduction using a novel PTS technique in OFDM-MIMO System

    OpenAIRE

    Kashish Sareen

    2012-01-01

    Orthogonal Frequency Division Multiplexing (OFDM) is an new multiplexing technique for 4G and 4.5G generation wireless communication. MIMO-OFDM is latest multiplexing technique which is resposible for high performance 4G broadband wireless communications. But there is one main disadvantage of MIMO-OFDM is the high peak-to-average power ratio (PAPR) of the transmitter’s output signal on different antennas. In this paper, we present a new noble (PTS) Partial transmit sequence technique to reduc...

  16. Patient’s satisfaction after 2-piece inflatable penile prosthesis implantation: An Italian multicentric study

    Directory of Open Access Journals (Sweden)

    Giorgio Gentile

    2016-03-01

    Full Text Available Introduction: Penile prosthesis implant represents a valuable solution for pts with severe erectile dysfunction (ED, non-responders to medical management. The aim of our study was to evaluate the satisfaction of patients (pts after 2-pieces inflatable penile prosthesis (IPP. Aim of the study: to evaluate safety, reliability and post-operative patient’s satisfaction after implantation of two-pieces IPP. Materials and Methods: This retrospective multicentric analysis concerns a group of 42 patients undergone 2-pieces IPP implantation from November 2005 to November 2013, in four Centers of proven experience. As a first step, a detailed review of all clinical reports was performed. Secondly, every patient was asked to fill the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS specifically modified, in order to assess their own satisfaction after surgery and, its impact on patient’s quality of sexual life. Results: 42 pts were evaluated (AMS-Ambicor: 28; Coloplast- Excell: 14; mean age, at time of operation: 60,7 years; mean follow up: 27,6 months; etiology of ED: vascular 23,8%, diabetes 19%, La Peyronie D. 7,1%, consequence of radical prostatectomy 31%, consequence of other pelvic surgery 11,9%, spinal trauma 7%. Mean operative time: 117 ± 58 min, mean postoperative hospital stay 3 ± 1,6 days. Post operative short-term complications: 4 pts (9,5%. Post operative long-term complications: 4 pts (9,5%. Long-term functional results (Questionnaire: 71% of pts (30 reported regular use of the prosthesis, at least 1 time/week, the satisfaction was good in 42% of pts (18, quite good in 33,3% (14, quite bad in 2,4% (1, very bad in 7,1% (3, 6 pts (14,4% didn’t answer. Conclusions: 2 pieces IPP appears to be associated with a low complication rate and good satisfaction of pts especially in the elderly. It also assures satisfactory rates of aesthetics and functional results.

  17. Modified PTS with FECs for PAPR Reduction in MIMO-OFDM System with Different Subblocks and Subcarriers

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    Mukunthan Pandurangan

    2011-07-01

    Full Text Available Multiple input multiple output orthogonal frequency division multiplexing (MIMO-OFDM systems have been proposed in the recent past for providing high data-rate services over wireless channels. When combined with space time coding it provides the advantages of space-time coding and OFDM, resulting in a spectrally efficient wideband communication system. However, MIMO OFDM systems suffer with the problem of inherent high peak-to-average power ratio (PAPR due to the intersymbol interference between the subcarriers. In order to obtain optimal PAPR reduction using the partial transmitted sequence (PTS, the total search for the number of subblocks and the rotation factors must be accomplished. As the number of subblocks and rotation factors increases, PAPR reduction improves. The number of calculation increases as the number of subblocks increases, such that complexity increases exponentially and the process delay occurs simultaneously. In this paper, a generalised framework for PAPR reduction for MIMO OFDM systems based on modified PTS using forward error-correcting codes (FECs such as Turbo codes and Golay codes are employed. PAPR reduction is jointly optimised in both the real and imaginary part by use of fast Fourier transform (FFT algorithm in the modified PTS which can be utilized for finding the optimum phase weighting factors, and can achieve the lower PAPR and computational complexity of MIMO OFDM systems. The simulation results show that the combined FEC with modified PTS technique significantly provides better PAPR reduction with reduced computational complexity compared to original PTS technique in the MIMOOFDM systems.

  18. Study of Ender’s Nailing in Shaft Femur Fractures of Older Children

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    Ladani HG

    2014-12-01

    Full Text Available Background: Fractures in shaft femur in children are relatively common. Various methods of treating these fractures starting from non operative to methods like closed intramedullary nailing are at our disposal. Traditionally non operative methods are acceptable and find wide acceptance even today in very young children. However in older children certain problems are encountered like failure to control angulation and shortening, prolonged immobilization which causes very much discomfort & the overgrowth phenomenon. In view of above difficulties, closed intramedullary nailing was attempted in older children and adolescents. I have tried to study 23 cases of shaft femur fractures in older children treated by Ender’s nails. Methodology: 22 pts., out of which one having bilateral # shaft femur (total 23 #s with age ranging from 7 to 16 yrs. were studied. 3 pts. having polio limbs studied separately. Fracture was in upper third shaft femur in 5 pts., middle third in 13 pts., lower third in 3pts. & involving more than one region in 2 pts. Fracture was transverse in 6 pts., spiral in 3 pts., oblique in 12 pts.& comminuted in 2 pts.. Results: Average union time was 10 weeks except in polio pts. where it was delayed. No nonunion, no infection. Excellent hip & knee movements in almost all pts. Out of 20 pts. ( except polio pts. limb length was equal in 17 pts., one pt. was having 1 cm. lengthening & 2 pts. were having shortening ( 1cm. & 2 cm.. Conclusion: Results of this study strongly favor the use of Ender’s nailing in shaft femur fractures in older children. Second surgery of implant removal is mandatory. Closed reduction can usually be achieved if surgery is performed earlier.

  19. Pre-test CFD simulations on TOPFLOW-PTS experiments with ANSYS CFX 12.0

    International Nuclear Information System (INIS)

    Some scenarios for Small Break Loss Of Coolant Accidents (SB-LOCA) lead to an Emergency Core Cooling (ECC) water injection into the cold leg of a Pressurized Water Reactor (PWR). The cold water mixes there with a hot coolant present in the primary circuit. The mixture flows to the downcomer where further mixing of fluids takes place. Single-phase as well as two-phase PTS (Pressurized Thermal Shock) situations have to be considered. Pressurized Thermal Shock implies the occurrence of thermal loads on the Reactor Pressure Vessel wall. In order to predict thermal gradients in the structural components of the Reactor Pressure Vessel (RPV) wall knowledge of transient temperature distribution in the downcomer is needed. The prediction of the temperature distribution requires reliable Computational Fluid Dynamic simulations. In case of two-phase PTS situations the water level in the RPV has dropped down to the height position of the cold leg nozzle or below leading to a partially filled or totally uncovered cold leg. In the frame of the EU project NURISP (Nuclear Reactor Integrated Simulation Project) attempts are made to improve the CFD modelling for two-phase PTS situations. This paper presents pre-test simulations on TOPFLOW-PTS experiments. The experiments will be carried out on the TOPFLOW-PTS test facility of the Forschungszentrum Dresden-Rossendorf. For the numerical investigations in the frame of NURISP two reference cases were defined: one for steady air-water and one for steady steam-water flow. The simulations were performed by using the CFD-code ANSYS CFX 12.0. Best practice guidelines were considered as far as possible. A homogeneous model was applied for momentum equations. Turbulence was modelled with the homogeneous Shear Stress Transport turbulence model. In all simulations the cold leg was 50 pc full of water. In case of air-water simulation the operating conditions for both fluids were 40 deg. C - 50 deg. C and 22.5 bar for the temperature and pressure

  20. Design and development of fast pneumatic transfer system (PTS) for instrumental neutron activation analysis at Jordan research reactor

    International Nuclear Information System (INIS)

    A pneumatic transfer system (PTS) is one of the important equipment used for an neutron irradiation of a target material for an instrumental neutron activation analysis (INAA) in a research reactor. In particular, a rapid pneumatic transportation of irradiation capsule is essential for an accurate measurement of a short half-life nuclide. Three types of PTS for NAA facility at the Jordan Research and Training Reactor (JRTR) were newly developed for a functional improvement involving a manual and an automatic system which is equipped with programmable logic controller, software, and 13 devices to facilitate optimal operation of the system. In this paper, the designs and construction of these PTS, the operation and control of the system are described. In addition, a functional and operational test of the system were carried out as one of the basic requirement and characteristic parameters, and the results were reported to provide a user information as well as for the management and safety of the reactor

  1. Assessment of efficacy of a new scheme of movalis administration in osteoarthritis and rheumatoid arthritis (data of a TOC \\o "1-5" \\h \\z Russian multicentr study

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    E S Tsvetkova

    2005-04-01

    Full Text Available Objective. To assess efficacy and safety of "stepped" therapy with movalis (consecutive parenteral administration during 3 days and oral during 20 days 15 mg/day for exacerbation of chronic pain in rheumatic diseases. Methods 262 pts with raheumatoid arthritis (RA and 384 pts with osteoarthritis (OA in 22 cities of Russia were included. Quantitative assessment (using 10-point scale of clinical parameters (pain at rest and at movement, severity of functional disturbances and local inflammation at different phases of therapy was performed. Frequency and character of adverse events in pts having risk factors of adverse events were analyzed. Results. Intramuscular movalis administration provided fast analgesic and anti-inflammatory effects which increased during the second phase (oral of treatment. Despite of presence risk factors adverse events were rare and mild. Conclusion. These data show high efficacy and safety of movalis in RA and OA.

  2. PTS regulation domain-containing transcriptional activator CelR and sigma factor σ(54) control cellobiose utilization in Clostridium acetobutylicum.

    Science.gov (United States)

    Nie, Xiaoqun; Yang, Bin; Zhang, Lei; Gu, Yang; Yang, Sheng; Jiang, Weihong; Yang, Chen

    2016-04-01

    The phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) regulation domain (PRD)-containing enhancer binding proteins (EBPs) are an important class of σ(54) -interacting transcriptional activators. Although PRD-containing EBPs are present in many Firmicutes, most of their regulatory functions remain unclear. In this study, the transcriptional regulons of about 50 PRD-containing EBPs in diverse Firmicutes species are reconstructed by using a comparative genomic approach, which contain the genes associated with utilization of β-glucosides, fructose/levan, mannose/glucose, pentitols, and glucosamine/fructosamine. We then present experimental evidence that the cel operon involved in cellobiose utilization is directly regulated by CelR and σ(54) (SigL) in Clostridium acetobutylicum. The predicted three CelR-binding sites and σ(54) promoter elements upstream of the cel operon are verified by in vitro binding assays. We show that CelR has an ATPase activity, which is strongly stimulated by the presence of DNA containing the CelR-binding sites. Moreover, mutations in any one of the three CelR-binding sites significantly decreased the cel promoter activity probably due to the need for all three DNA sites for maximal ATPase activity of CelR. It is suggested that CelR is regulated by PTS-mediated phosphorylation at His-551 and His-829, which exerts a positive effect and an inhibitory effect, respectively, on the CelR activity. PMID:26691835

  3. Penicillium chrysogenum Pex5p mediates differential sorting of PTS1 proteins to microbodies of the methylotrophic yeast Hansenula polymorpha

    OpenAIRE

    Kiel, Jan A. K. W.; Berg, Marco van den; Bovenberg, Roel A. L.; van der Klei, Ida J.; Veenhuis, Marten

    2004-01-01

    We have isolated the Penicillium chrysogenum pex5 gene encoding the receptor for microbody matrix proteins containing a type 1 peroxisomal targeting signal (PTS1). Pc-pex5 contains 2 introns and encodes a protein of approximately 75 kDa. P. chrysogenum pex5 disruptants appear to be highly unstable, show poor growth, and are unable to sporulate asexually. Furthermore, pex5 cells mislocalize a fluorescent PTS1 reporter protein to the cytosol. Pc-pex5 was expressed in a PEX5 null mutant of the y...

  4. Thermal hydraulic evaluation for an experimental facility to investigate pressurized thermal shock (PTS) in CDTN/CNEN; Avaliacao termo-hidraulica da montagem experimental de choque termico pressurizado do CDTN/CNEN

    Energy Technology Data Exchange (ETDEWEB)

    Palmieri, Elcio T.; Navarro, Moyses A.; Aronne, Ivam D.; Terra, Jose L. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil)

    2002-07-01

    The goal of the work presented in this paper is to provide necessary thermal hydraulics information to the design of an experimental installation to investigate the Pressurized Thermal Shock (PTS) to be implemented at Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN). The envisaged installation has a test section that represents, in a small scale, a pressure vessel of a nuclear reactor. This test section will be heated and then exposed to a PTS in order to evaluate the appearance and development of cracks. To verify the behavior of the temperatures of the pressure vessel after a sudden flood through the annulus, calculations were made using the RELAP5/MOD 3.2.2 gamma code. Different outer radiuses were studied for the annular region. The results showed that the smaller annulus spacing (20 mm) anticipates the wetting of the surface and produces a higher cooling of the external surface, which stays completely wet for a longer time. (author)

  5. New PAPR Reduction in an OFDM System Using Hybrid of PTS-CAPPR Methods with GA Coded Side Information Technique

    Science.gov (United States)

    Pradabpet, Chusit; Yoshizawa, Shingo; Miyanaga, Yoshikazu; Dejhan, Kobchai

    In this paper, we propose a new PAPR reduction by using the hybrid of partial transmit sequences (PTS) and cascade adaptive peak power reduction (CAPPR) methods with side information (SI) technique coded by genetic algorithm (GA). These methods are used in an Orthogonal Frequency Division Multiplexing (OFDM) system. The OFDM employs orthogonal sub-carriers for data modulation. These sub-carriers unexpectedly present a large peak to average power ratio (PAPR) in some cases. A proposed reduction method realizes both the advantages of PTS and CAPPR at the same time. In order to obtain the optimum condition on PTS for PAPR reduction, a quite large calculation cost is demanded and thus it is impossible to obtain the optimum PTS in a short time. In the proposed method, by using the pseudo-optimum condition based on a GA coded SI technique, the total calculation cost becomes drastically reduced. In simulation results, the proposed method shows the improvement on PAPR and also reveals the high performance on bit error rate (BER) of an OFDM system.

  6. New PAPR Reduction in OFDM System Using Hybrid of PTS-APPR Methods with Coded Side Information Technique

    Science.gov (United States)

    Pradabpet, Chusit; Yoshizawa, Shingo; Miyanaga, Yoshikazu; Dejhan, Kobchai

    In this paper, we propose a new PAPR reduction by using the hybrid of a partial transmit sequences (PTS) and an adaptive peak power reduction (APPR) methods with coded side information (SI) technique. These methods are used in an Orthogonal Frequency Division Multiplexing (OFDM) system. The OFDM employs orthogonal sub-carriers for data modulation. These sub-carriers unexpectedly present a large Peak to Average Power Ratio (PAPR) in some cases. In order to reduce PAPR, the sequence of input data is rearranged by PTS. The APPR method is also used to controls the peak level of modulation signals by an adaptive algorithm. A proposed reduction method consists of these two methods and realizes both advantages at the same time. In order to make the optimum condition on PTS for PAPR reduction, a quite large calculation cost must be demanded and thus it is impossible to obtain the optimum PTS. In the proposed method, by using the pseudo-optimum condition with a coded SI technique, the total calculation cost becomes drastically reduced. In simulation results, the proposed method shows the improvement on PAPR and also reveals the high performance on bit error rate (BER) of an OFDM system.

  7. Cataracts following bone marrow transplantation (BMT) conditioned with total body irradiation (TBI) for acute leukemia (AL) in complete remission (CR): a study of the European group for blood and marrow transplantation

    International Nuclear Information System (INIS)

    Purpose: The advances in BMT over the past twenty years have greatly improved long term survival of patients (pts), therefore the evaluation of late complications such as cataract is of paramount importance. In order to assess the influence of several parameters on cataract formation and the risk for requiring surgery for sever opacification after BMT, we analyzed the collected data of 2149 pts from 48 EBMT centers. Patients and Methods: As of June 1996 among the 2149 questionnaires, data from 1760 pts were evaluable for survival with a median follow-up of 76 months (12-165). One thousand and ninty four pts have survived more than one year after BMT, including 5 pts who developed cataract during the first year. Thirty one pts with no ophthalmologic follow-up were excluded from the study, therefore the analyses concerned 1063 AL pts (Lymphoblastic: n = 567, 53%; Myeloblastic: n = 490, 46%; Undifferenciated: n = 6, 1%), allografted (n = 688, 65%) or autografted (n = 375, 35%) in first CR (n = 788, 74%) or in 2nd CR (n = 275, 26%). The median age was 23 years (1-57). Male to female ratio was 1.56 ((648(415))). The conditioning chemotherapy consisted of cyclophosphamide alone in 724 (68%) pts. Single dose TBI (STBI) was given a median dose of 10 Gy (6-11.82) to the mid-plane of abdomen in 495 (46%) pts, whereas fractionated regimens (FTBI; 2 to 12 fractions) were used in 568 (54%) pts, delivering a median dose of 12 Gy (8.5-12). Median dose rate (DR) was 0.06 Gy/min (0.018-0.3) in the STBI group, and 0.065 Gy/min (0.012-0.56) in the FTBI ≤ 6F group. Fifty two (5%) pts had prophylactic cranial radiotherapy delivering a median dose of 18 Gy (4-25). The administration of steroids for any reason was registered in 316 (30%) pts, and heparin as venocclusive disease (VOD) prevention in 195 (18%) pts. Results: After a median follow-up period of 76 months, (257(1063)) (24%) pts developed cataracts (unilateral in 18 and bilateral in 239 cases) with a 5 and 10-year estimated

  8. Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility.

    Directory of Open Access Journals (Sweden)

    Yumi Mizuno

    Full Text Available Peroxisomes are subcellular organelles involved in lipid metabolic processes, including those of very-long-chain fatty acids and branched-chain fatty acids, among others. Peroxisome matrix proteins are synthesized in the cytoplasm. Targeting signals (PTS or peroxisomal targeting signal at the C-terminus (PTS1 or N-terminus (PTS2 of peroxisomal matrix proteins mediate their import into the organelle. In the case of PTS2-containing proteins, the PTS2 signal is cleaved from the protein when transported into peroxisomes. The functional mechanism of PTS2 processing, however, is poorly understood. Previously we identified Tysnd1 (Trypsin domain containing 1 and biochemically characterized it as a peroxisomal cysteine endopeptidase that directly processes PTS2-containing prethiolase Acaa1 and PTS1-containing Acox1, Hsd17b4, and ScpX. The latter three enzymes are crucial components of the very-long-chain fatty acids β-oxidation pathway. To clarify the in vivo functions and physiological role of Tysnd1, we analyzed the phenotype of Tysnd1(-/- mice. Male Tysnd1(-/- mice are infertile, and the epididymal sperms lack the acrosomal cap. These phenotypic features are most likely the result of changes in the molecular species composition of choline and ethanolamine plasmalogens. Tysnd1(-/- mice also developed liver dysfunctions when the phytanic acid precursor phytol was orally administered. Phyh and Agps are known PTS2-containing proteins, but were identified as novel Tysnd1 substrates. Loss of Tysnd1 interferes with the peroxisomal localization of Acaa1, Phyh, and Agps, which might cause the mild Zellweger syndrome spectrum-resembling phenotypes. Our data established that peroxisomal processing protease Tysnd1 is necessary to mediate the physiological functions of PTS2-containing substrates.

  9. Synthesis and Physicochemical Characterization of D-Tagatose-1-phosphate: The Substrate of the Tagatose-1-Phosphate Kinase TagK in the PTS-mediated D-Tagatose Catabolic Pathway of Bacillus licheniformis

    Science.gov (United States)

    Van der Heiden, Edwige; Delmarcelle, Michaël; Simon, Patricia; Counson, Melody; Galleni, Moreno; Freedberg, Darón I.; Thompson, John; Joris, Bernard; Battistel, Marcos D.

    2015-01-01

    We report the first enzymatic synthesis of D-tagatose-1-phosphate (Tag-1P) by the multi-component PEP-dependent:tag-PTS present in tagatose-grown cells of Klebsiella pneumoniae. Physicochemical characterization by 31P and 1H NMR spectroscopy reveals that, in solution, this derivative is primarily in the pyranose form. Tag-1P was used to characterize the putative tagatose-1-phosphate kinase (TagK) of the Bacillus licheniformis PTS-mediated D-Tagatose catabolic Pathway (Bli-TagP). For this purpose, a soluble protein fusion was obtained with the 6 His-tagged trigger factor (TFHis6) of Escherichia coli. The active fusion enzyme was named TagK-TFHis6. Tag-1P and D-fructose-1-phosphate (Fru-1P) are substrates for the TagK-TFHis6 enzyme, whereas the isomeric derivatives D-tagatose-6-phosphate (Tag-6P) and D-fructose-6-phosphate (Fru-6P) are inhibitors. Studies of catalytic efficiency (kcat/Km) reveal that the enzyme specificity is markedly in favor of Tag-1P as substrate. Importantly, we show in vivo that the transfer of the phosphate moiety from PEP to the B. licheniformis tagatose-specific enzyme II (EIITag) in E.coli is inefficient. The capability of the PTS general cytoplasmic components of B. subtilis, HPr and EI, to restore the phosphate transfer is demonstrated. PMID:26159072

  10. A phase I study of paclitaxel as a radiation sensitizer for the treatment of non-small cell lung cancer and mesothelioma

    International Nuclear Information System (INIS)

    Purpose/Objective Paclitaxel exposure of cancer cells in vitro results in a G2/M block in the cell cycle. Paclitaxel also has independent activity against a wide variety of tumors. We report here a phase I study of patients with non-small cell lung cancer and malignant pleural mesothelioma treated with radiation therapy and concurrent paclitaxel. Objectives were to determine the maximum tolerated dose (MTD) of paclitaxel when delivered as a 5-day continuous infusion with concurrent radiotherapy, to assess tumor response and toxicity, and to evaluate the biological effects of paclitaxel in tumor biopsy specimens. Materials and Methods 19 patients (pts.) were enrolled on study. 17 pts. were male and 2 were female. 18 pts. had mesothelioma and 1 had non-small cell lung cancer. Mean age was 59 yrs with a range of 47 to 72 years. One patient did not complete treatment due to progressive disease. Patients who completed treatment received from 5760 to 6300 cGy. Dose volume histography and multiple non-coplanar and non-coaxial fields were used. Patients received a continuous infusion of paclitaxel for 120 hours every three weeks during radiation therapy. The Results MTD of paclitaxel was determined to be 105 mg/m2 delivered as a 120-hour continuous infusion. The dose-limiting toxicity of paclitaxel was neutropenia at 120 mg/m2 given over 120 hrs. 13 patients were assessable for local control; 4 pts. are too early to evaluate and 2 pts. did not return for follow-up. (11(13)) pts. achieved local control. 3 of 13 patients are free of disease. 10 tumor biopsies were taken from 4 mesothelioma pts. Biopsies were taken prior to the paclitaxel infusion and then during the infusion. A modest G2/M block was observed in only 1 of the 5 specimens taken during the paclitaxel infusion. Conclusions This study demonstrates that paclitaxel can be safely delivered as a 120-hour continuous infusion at 105 mg/m2 with concurrent thoracic radiotherapy. However, the biologic effect of paclitaxel

  11. Alflutop efficacy in chronic vertebrogenous lumbar ischialgia. A double blind placebo controlled study

    Directory of Open Access Journals (Sweden)

    O S Levin

    2004-08-01

    Full Text Available Objective. To assess efficacy and safety of intramuscular (im and paravertebral (pv alflutop injections in pts with chronic vertebrogenous lumbar ischialgia. Material and methods. 83 pts with lumbar ischialgia syndrome (44 male, 39 female aged 31 to 56 years (mean 43,1 ±5,2 years were included. Disease duration varied from I to 7 years (mean 3,5± 1,9 years, duration of the present exacerbation - from 1 to 4 months (mean 2.4±0,8 months. Vertebroneurologic diagnosis was made according to H. Hall criteria. Pts were randomized into 4 groups. 32 pts of group Al received im, 23 pts of group A2 - pv alflutop injections. 14 pts of group Bl and 14 pts of group B2 received im and pv placebo injections respectively. Treatment results were scored by the doctor. Pts assessed spine pain changes on visual analog scale. Quantitative assessment of verbal syndrome was performed with Waddle scale. Results. Im alflutop injections provided good or fair effect in 61%, pv - in 69% of pts (significantly better than placebo. Effect was evident during the first 2 weeks of treatment and persisted for 3 months after its termination. The best results were achieved in pts with facet syndrome, the worst - in spinal stenosis. Drug tolerability was good in both modes of administration.

  12. Portfolio assessment: practice teachers' early experience.

    Science.gov (United States)

    Spence, William; El-Ansari, Walid

    2004-07-01

    Experience was recognised to be a vital source of learning as long ago as 1762 [Emile, Everyman, London, 1993] and reflection on practice experience may be one way forward in addressing nursing's anxieties concerning the practice theory gap. However, despite the acceptance that subjectivity in the process seems inevitable and potentially important, little is understood of the practitioner's experience of practice assessment. Two questionnaires sought the views of specialist community nursing practitioner (SCNP) programme (United Kingdom Central Council for Nursing, Midwifery and Health Visiting (UKCC) 2001) practice teachers (PTs) on the introduction of the portfolio approach to practice assessment. These were distributed to 62 and 76 PTs and the response rates were 32% and 50%, respectively. Responses of those PTs from the three specialisms participating in the piloting of the portfolio approach were compared with those using an existing approach. An action research method was adopted which attempted to use established theory to explain the challenges presented by the introduction of this approach and ultimately to raise the PT group's awareness of assessment issues. Both qualitative and quantitative data were collected and the findings support the use of the portfolio approach to practice assessment. The PT experience of portfolio use was found to be a largely positive one. PTs reported the utility of the portfolio in prompting student self-evaluation of learning. Concerns were expressed by PTs around the quality of portfolio evidence although many felt that it had promoted students' reflection on practice. Inter-PT reliability in practice assessment was identified as a topic for PT continuing professional development. Many sources of evidence, including patient feedback, were used by PTs in their assessment of students although PTs using the portfolio approach used less first-hand experience of students' practice in their assessments of competence, relying more

  13. Development of a viscoplastic dynamic fracture mechanics treatment for crack arrest predictions in a PTS event

    International Nuclear Information System (INIS)

    The objective of this research is to develop a fundamentally correct methodology for the prediction of crack arrest at the high upper shelf conditions occurring in a postulated pressurized thermal shock (PTS) event. The effort is aimed at the development of a versatile finite-element method for the solution of time-dependent boundary value problems that admit inertia effects, a prescribed spatial temperature distribution, and viscoplastic constitutive and fracture behavior. Supporting this development are (1) material characterization and fracture experimentation, (2) detailed mathematical analyses of the near-tip region, (3) elastodynamic fracture analysis, and (4) elastic-plastic tearing instability analyses. As a first step, dynamic-viscoplastic analyses are currently being made of the wide plate tests being performed by the National Bureau of Standards in a companion HSST program. Some preliminary conclusions drawn from this work and from the supporting research activities are offered in this paper. The outstanding critical issues that subsequent research must focus on are also described

  14. CLINICAL EFFICACY OF THE DRUG STRUCTUM IN OSTEOARTHRITIS THERAPY (results of multicenlral clinical study in Russia

    Directory of Open Access Journals (Sweden)

    V A Nassonova

    2001-01-01

    Full Text Available Objective. Study of the efficacy and tolerability of Structum in pts with gonarthritis and coxarthritis during 6 months therapy. Material. Open multicentral study included off -patients of both sexes with osteoarthritis (ОЛ of knee and hip joints with obvious pain syndrome - pain in walking 30 mm and more on visual analog scale, functional Lesquene index more or equal to 4 and less or equal toll, regular NSAIDs taking for 30 days for the last 3 months, radiological I-II-III OA stage according Kellgren-Lawrence and consent of the patient for the study. Total number of pts included was 555 and 192 out of them were experimental group and 363 - controls. Pts from experimental group had Structum - three capsules in the morning and 3 capsules in the evening during meals (one capsule - 250 mg for 3 weeks, then 2 capsules in the morning and 2 in the evening for 21 weeks. Clinical examination of pts was done after the third and sixth month of the treatment. Results. During Structum therapy reliable lessening of pain syndrome in knee and hip joints, improvement of articular function, decrease of NSAIDs dosage or their full cancellation were demonstrated. It was noticed that the assessment of clinical Structum efficacy and tolerability bu physician and patient coincided. Conclusion. Structum (chondroitin sulfate is a new effective drug for treatment of osteoarthritis of knee and hip joints with high clinical efficacy and good tolerability

  15. Catabolic regulation analysis of Escherichia coli and its crp, mlc, mgsA, pgi and ptsG mutants

    Directory of Open Access Journals (Sweden)

    Yao Ruilian

    2011-08-01

    Full Text Available Abstract Background Most bacteria can use various compounds as carbon sources. These carbon sources can be either co-metabolized or sequentially metabolized, where the latter phenomenon typically occurs as catabolite repression. From the practical application point of view of utilizing lignocellulose for the production of biofuels etc., it is strongly desirable to ferment all sugars obtained by hydrolysis from lignocellulosic materials, where simultaneous consumption of sugars would benefit the formation of bioproducts. However, most organisms consume glucose prior to consumption of other carbon sources, and exhibit diauxic growth. It has been shown by fermentation experiments that simultaneous consumption of sugars can be attained by ptsG, mgsA mutants etc., but its mechanism has not been well understood. It is strongly desirable to understand the mechanism of metabolic regulation for catabolite regulation to improve the performance of fermentation. Results In order to make clear the catabolic regulation mechanism, several continuous cultures were conducted at different dilution rates of 0.2, 0.4, 0.6 and 0.7 h-1 using wild type Escherichia coli. The result indicates that the transcript levels of global regulators such as crp, cra, mlc and rpoS decreased, while those of fadR, iclR, soxR/S increased as the dilution rate increased. These affected the metabolic pathway genes, which in turn affected fermentation result where the specific glucose uptake rate, the specific acetate formation rate, and the specific CO2 evolution rate (CER were increased as the dilution rate was increased. This was confirmed by the 13C-flux analysis. In order to make clear the catabolite regulation, the effect of crp gene knockout (Δcrp and crp enhancement (crp+ as well as mlc, mgsA, pgi and ptsG gene knockout on the metabolism was then investigated by the continuous culture at the dilution rate of 0.2 h-1 and by some batch cultures. In the case of Δcrp (and also

  16. Development of Pneumatic Transfer Irradiation Facility (PTS no.3) for Neutron Activation Analysis at HANARO Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Kim, S. H.; Sun, G. M.; Baek, S. Y.; Kim, H. R.; Kim, Y. J

    2008-04-15

    A pneumatic transfer system (PTS) is one of the most important facilities used during neutron irradiation of a target material for instrumental neutron activation analysis (INAA) in a research reactor. In particular, a fast pneumatic transfer system is essential for the measurement of a short half-life nuclide. The pneumatic transfer irradiation system (PTS no.3) involving a manual system and an semi-automatic system were reconstructed with new designs of a functional improvement at the HANARO research reactor and NAA laboratory of RI building in 2006. In this technical report, the design, operation and control of these system (PTS no.3) was described. Also the experimental results and the characteristic parameters measured from a functional operation test and an irradiation test of these systems, such as the transfer time of irradiation capsule, the different neutron flux, the temperature of the irradiation position with an irradiation time, the radiation dose rate when the rabbit is returned, etc. are reported to provide a user information as well as a reactor's management and safety.

  17. Development of Pneumatic Transfer Irradiation Facility (PTS no.2) for Neutron Activation Analysis at HANARO Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Kim, S. H.; Sun, G. M.; Baek, S. Y.; Kim, H. R.; Kim, Y. J

    2008-03-15

    A pneumatic transfer irradiation system (PTS) is one of the most important facilities used during neutron irradiation of a target material for instrumental neutron activation analysis (INAA) in a research reactor. In particular, a fast pneumatic transfer system is essential for the measurement of a short half-life nuclide and a delayed neutron counting system. The pneumatic transfer irradiation system (PTS no.2) involving a manual system and an automatic system for delayed neutron activation analysis (DNAA) were reconstructed with new designs of a functional improvement at the HANARO research reactor in 2006. In this technical report, the conception, design, operation and control of PTS no.2 was described. Also the experimental results and the characteristic parameters measured by a mock-up test, a functional operation test and an irradiation test of these systems, such as the transfer time of irradiation capsule, automatic operation control by personal computer, delayed neutron counting system, the different neutron flux, the temperature of the irradiation position with an irradiation time, the radiation dose rate when the rabbit is returned, etc. are reported to provide a user information as well as a reactor's management and safety.

  18. Development of Pneumatic Transfer Irradiation Facility (PTS no.1) for Neutron Activation Analysis at HANARO Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Kim, S. H.; Sun, G. M.; Baek, S. Y.; Kim, H. R.; Kim, Y. J

    2008-03-15

    A pneumatic transfer system (PTS) is one of the most important facilities used during neutron irradiation of a target material for instrumental neutron activation analysis (INAA) in a research reactor. In particular, a fast pneumatic transfer system is essential for the measurement of a short half-life nuclide and a delayed neutron counting system. The pneumatic transfer system (PTS no.1) involving a manual system and an semiautomatic system were reconstructed with new designs of a functional improvement at the HANARO research reactor in 2006. In this technical report, the conception, design, operation and control of these system (PTS no.1) was described. Also the experimental results and the characteristic parameters measured by a mock-up test, a functional operation test and an irradiation test of these systems, such as the transfer time of irradiation capsule, the different neutron flux, the temperature of the irradiation position with an irradiation time, the radiation dose rate when the rabbit is returned, etc. are reported to provide a user information as well as a reactor's management and safety.

  19. A PhD abstract presentation on Cluster Framework for Internet of People, Things and Services (IoPTS)

    DEFF Research Database (Denmark)

    Shinde, Gitanjali; Olesen, Henning

    2014-01-01

    The Internet of Things (IoT) is a revolutionary technology, where devices around us are capable of sensing, reacting, responding and working autonomously to provide services to the users /people, e.g. smart homes, enterprise, utilities and e-Health. In the IoT paradigm, every device will be conne......The Internet of Things (IoT) is a revolutionary technology, where devices around us are capable of sensing, reacting, responding and working autonomously to provide services to the users /people, e.g. smart homes, enterprise, utilities and e-Health. In the IoT paradigm, every device...... will be connected to the Internet to provide services to the user. Bringing this together makes it relevant to talk about the "Internet of People, Things and Services (IoPTS)."However, managing such a huge number of devices is a major challenge for IoPTS. In any given context, a number of devices will work together...... announce their services to those who need them. Users can access these services with the help of widely interconnected devices. To access the services user has to provide some personal data. In IoPTS services are large in numbers, and to protect the user data there is a need to ensure that these services...

  20. Assessing Vocal Performances Using Analytical Assessment: A Case Study

    Science.gov (United States)

    Gynnild, Vidar

    2016-01-01

    This study investigated ways to improve the appraisal of vocal performances within a national academy of music. Since a criterion-based assessment framework had already been adopted, the conceptual foundation of an assessment rubric was used as a guide in an action research project. The group of teachers involved wanted to explore thinking…

  1. Geology, Surficial - CLAY_ILITH_PTS_IN: Total Thickness of Clay in Indiana, Derived from the iLITH Water-Well Database (Indiana Geological Survey, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — CLAY_ILITH_PTS_IN is a point shapefile that shows total thickness of clay, as derived from logs of water wells in the state of Indiana. (It presents the source data...

  2. A programme of studies including assessment of diagnostic accuracy of school hearing screening tests and a cost-effectiveness model of school entry hearing screening programmes.

    Science.gov (United States)

    Fortnum, Heather; Ukoumunne, Obioha C; Hyde, Chris; Taylor, Rod S; Ozolins, Mara; Errington, Sam; Zhelev, Zhivko; Pritchard, Clive; Benton, Claire; Moody, Joanne; Cocking, Laura; Watson, Julian; Roberts, Sarah

    2016-01-01

    with confirmed hearing impairment were older at referral in the site with SES (mean age difference 0.47 years, 95% CI 0.24 to 0.70 years; p < 0.001). Parental responses revealed that the consequences to the family of the referral process are minor. A SES programme is unlikely to be cost-effective and, using base-case assumptions, is dominated by a no screening strategy. A SES programme could be cost-effective if there are fewer referrals associated with SES programmes or if referrals occur more quickly with SES programmes. CONCLUSIONS A SES programme using the PTS or HC screener is unlikely to be effective in increasing the identified number of cases with hearing impairment and lowering the average age at identification and is therefore unlikely to represent good value for money. This finding is, however, critically dependent on the results of the observational study comparing Nottingham and Cambridge, which has limitations. The following are suggested: systematic reviews of the accuracy of devices used to measure hearing at school entry; characterisation and measurement of the cost-effectiveness of different approaches to the ad-hoc referral system; examination of programme specificity as opposed to test specificity; further observational comparative studies of different programmes; and opportunistic trials of withdrawal of SES programmes. TRIAL REGISTRATION Current Controlled Trials ISRCTN61668996. FUNDING This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 20, No. 36. See the NIHR Journals Library website for further project information. PMID:27169435

  3. Monitoring study and impact assessment

    OpenAIRE

    Budidarsono, Suseno; Rahmanulloh, Arif

    2008-01-01

    Report on the progress of socio-economic objective of LTRP 5 in Indonesia. The objectives were: (1) Identify vegetable cultivation technology on agroforestry system that socially acceptable, economically feasible, and affordable; (2) Provide information on the level adoption of vegetable cultivation technology in agroforestry system and (3)Assess impacts of technology adoption on farmers' incomes.

  4. An Assessment Tool Translation Study

    OpenAIRE

    Buchanan, Joan L.; Andres, Patricia L.; Haley, Stephen M; Paddock, Susan M.; Zaslavsky, Alan M.

    2003-01-01

    Policymakers hoped to substitute a new, multi-purpose, functional assessment instrument, the minimum data set post-acute care (MDS-PAC), into the planned prospective payment system (PPS) for inpatient rehabilitation hospitals. PPS design requires a large database linking treatment costs with measures of the need for care, so the PPS was designed using the functional independence measure (FIM™) database linked to Medicare hospital claims. An accurate translation from the MDS-PAC items to FIM™-...

  5. STUDY OF THE THERMAL STRATIFICATION IN PWR REACTORS AND THE PTS (PRESSURIZED THERMAL SHOCK) PHENOMENON

    OpenAIRE

    ROMERO HAMERS, ADOLFO

    2014-01-01

    In the event of hypothetical accident scenarios in PWR, emergency strategies have to be mapped out, in order to guarantee the reliable removal of decay heat from the reactor core, also in case of component breakdown. One essential passive heat removal mechanism is the reflux condensation cooling mode. This mode can appear for instance during a small break loss-of-coolant-accident (LOCA) or because of loss of residual heat removal (RHR) system during mid loop operation at plant outage after th...

  6. Collaborative Assessment: Middle School Case Study

    Science.gov (United States)

    Parkison, Paul T.

    2014-01-01

    Utilizing a participant observer research model, a case study of the efficacy of a collaborative assessment methodology within a middle school social studies class was conducted. A review of existing research revealed that students' perceptions of assessment, evaluation, and accountability influence their intrinsic motivation to learn. A…

  7. Improved PTS for PAPR Reduction in OFDM System%抑制OFDM系统PAPR的PTS算法改进

    Institute of Scientific and Technical Information of China (English)

    汪锦州

    2009-01-01

    部分传输序列(PTS)是一种降低OFDM信号的峰值平均功率比(PAPR)的有效方法.PTS采用是在子序列中添加旋转相位因子[0,2 π).通过对OFDM信号相位分布情况进行研究,本文提出一种改进的PTS方法.改进点在其相位旋转因子的选择上,采用每个子块乘以非均匀分布的旋转因子.

  8. Reciclaje de edificaciones para centros de investigaci??n y atenci??n sanitaria en ??mbitos adscritos al PTS Granada

    OpenAIRE

    Mart??nez-Monedero, Miguel

    2010-01-01

    Este art??culo aborda una reflexi??n sobre la ciudad contempor??nea. Una ciudad que hemos heredado de generaciones que nos preceden y que debemos transmitir a las generaciones que nos seguir??n, sobre su transformaci??n no traum??tica, fundamentalmente dirigida al reciclaje y renovaci??n de edificaciones degradadas y obsoletas. La investigaci??n que se expone abre nuevas v??as de estudio. Fruto del estudio del ??rea urbana pr??xima al actual PTS Granada, y en particular del popular barrio del...

  9. Study of seismic probabilistic safety assessment methodology

    International Nuclear Information System (INIS)

    There are two Seismic Risk Assessment Methodologies in the world, Seismic Margin Assessment (SMA) and Seismic Probabilistic Safety Assessment (PSA). SMA can provide the risk insights qualitatively and it is helpful in risk informed decision making for nuclear power plant, while Seismic PSA can provide more comprehensive and detailed risk insights quantitatively. The study of the Seismic PSA methodology is carried out, based on the AP1000 SMA, which is mastered. (authors)

  10. Dietary assessment methods in epidemiologic studies

    OpenAIRE

    Shim, Jee-Seon; Oh, Kyungwon; Kim, Hyeon Chang

    2014-01-01

    Diet is a major lifestyle-related risk factor of various chronic diseases. Dietary intake can be assessed by subjective report and objective observation. Subjective assessment is possible using open-ended surveys such as dietary recalls or records, or using closed-ended surveys including food frequency questionnaires. Each method has inherent strengths and limitations. Continued efforts to improve the accuracy of dietary intake assessment and enhance its feasibility in epidemiological studies...

  11. Experimental tests and validation of calculation criteria of acceptable Tk shift with respect to PTS at VVER

    International Nuclear Information System (INIS)

    The following topics were examined: (i) Methodology of fracture tests at temperature gradients and pressurized thermal shock (PTS) cooling tests on large specimens (1500x1200x140 mm) with a designed postulated crack and other smaller cracks in the cooled area (test performed on a ZZ 8000 (80MN) loading stand); (ii) simulation of radiation embrittlement of tested material near the end of the RPV designed life, the material is subjected to standard mechanical property tests and fracture tests of standard test specimens modelling the PTS regime of material loading; (iii) 100% NDT tests of a specimen before the beginning of tests and μTOFD before and after each particular test of a specimen; (iv) on-line monitoring of the test conditions based on instrumentation of a specimen with thermocouples, COD and strain gauges together with on-line monitoring of Acoustic Emission during the tests; (v) calculation of Kl at the critical points of the crack front during the test, based on monitored boundary conditions; (vi) fractographic analysis after the fracture of a specimen and evaluation of the whole test. (P.A.)

  12. Fully 3D Particle-in-Cell Simulation of Double Post-Hole Convolute on PTS Facility

    Science.gov (United States)

    Zhao, Hailong; Dong, Ye; Zhou, Haijing; Zou, Wenkang; Institute of Fluid Physics Collaboration; Institute of Applied Physics; Computational Mathematics Collaboration

    2015-11-01

    In order to get better understand of energy transforming and converging process during High Energy Density Physics (HEDP) experiments, fully 3D particle-in-cell (PIC) simulation code NEPTUNE3D was used to provide numerical approach towards parameters which could hardly be acquired through diagnostics. Cubic region (34cm × 34cm × 18cm) including the double post-hole convolute (DPHC) on the primary test stand (PTS) facility was chosen to perform a series of fully 3D PIC simulations, calculating ability of codes were tested and preliminary simulation results about DPHC on PTS facility were discussed. Taking advantages of 3D simulation codes and large-scale parallel computation, massive data (~ 250GB) could be acquired in less than 5 hours and clear process of current transforming and electron emission in DPHC were demonstrated with the help of visualization tools. Cold-chamber tests were performed during which only cathode electron emission was considered without temperature rise or ion emission, current loss efficiency was estimated to be 0.46% ~ 0.48% by comparisons between output magnetic field profiles with or without electron emission. Project supported by the National Natural Science Foundation of China (Grant No. 11205145, 11305015, 11475155).

  13. Therapy monitoring based on FDG-PET follow-up studies for the prediction of individual survival

    International Nuclear Information System (INIS)

    Abstract: Dynamic PET studies with 18F-FDG were performed in patients with advanced Non-small Cell Lung Cancer (NSCLC) who received palliative chemotherapy to evaluate the impact of full kinetic analysis and assess its value with regard to short or long survival. Furthermore, we performed FDG-PET studies in patients (pts) with metastatic colorectal cancer receiving FOLFOX (5 fluorouracil, folinic acid and oxaliplatin) chemotherapy and evaluated different quantification methods for prediction of individual survival. (author)

  14. Study on Assessment of Mine Environments

    Institute of Scientific and Technical Information of China (English)

    WU Qiang; LI Wei; LI Ruijun

    2008-01-01

    Mine environmental evaluation is the key to mine environmental study. On the basis of the characteristics of the mine environmental problems, they are classified into (1) three wastes problem, (2) ground distortion, (3) contradiction among mine drainage, water supply, ecological environment,(4) desertification, and (5) soil erosion. The evaluation is the basis of mine environmental problem classification and investigation, mine environmental rehabilitation, and the information system constructed can be used for subsequent research of evaluation techniques. A synthetic assessment of the 5 kinds of mine environmental problems can be divided into single-factor or multi-factor synthetic assessments; while by the viewpoint of time, the mine environmental assessment can be classified as the historical assessment, the current status assessment and the forecasting assessment.

  15. Assessing the Academic Benefit of Study Abroad

    Science.gov (United States)

    Cisneros-Donahue, Teresa; Krentler, Kathleen A.; Reinig, Bruce; Sabol, Karey

    2012-01-01

    Study abroad is a growing phenomenon in higher education. Although such growth is typically lauded, efforts to measure the impact of international experiences on student learning have been limited. This study assesses the academic benefit of a study abroad program, offered by a U.S. university, with measures of self-reported learning. Study abroad…

  16. Viscoplastic-dynamic analyses of small-scale fracture tests to obtain crack arrest toughness values for PTS conditions

    International Nuclear Information System (INIS)

    Reliable predictions of crack arrest at the high upper shelf toughness conditions involved in postulated pressurized thermal shock (PTS) events require procedures beyond those utilized in conventional fracture mechanics treatments. To develop such a procedure, viscoplastic-dynamic fracture mechanics finite element analyses, viscoplastic material characterization testing, and small-scale crack propagation and arrest experimentation are being combines in this research. The approach couples SwRI's viscoplastic-dynamic fracture mechanics finite element code VISCRK with experiments using duplex 4340/A533B steel compact specimens. The experiments are simulated by VISCRK computations employing the Bodner-Partom viscoplastic constitutive relation and the nonlinear fracture mechanics parameter T. The goal is to develop temperature-dependent crack arrest toughness values for A533B steel. While only room temperature KIa values have been obtained so far, these have been found to agree closely with those obtained from wide plate tests. (author)

  17. Environmental Impact Assessment Studies in Additive Manufacturing

    OpenAIRE

    Kerbrat, Olivier; Le Bourhis, Florent; MOGNOL, Pascal; Hascoët, Jean-Yves

    2016-01-01

    International audience This chapter focuses on the environmental studies in additive manufacturing. For a cleaner production, environmental impacts that occur during the manufacturing phase should be assessed with accuracy. First, the literature on all the studies led to the characterization of the environmental impact of additive manufacturing processes. The studies on electric energy consumption of these processes are analyzed here, and then some studies taking into account raw material ...

  18. Special Education Faculty Needs Assessment Study Implications

    Science.gov (United States)

    Smith, D.D.; Tyler, N.; Montrosse, B.E.; Young, C.; Robb, S.M.

    2011-01-01

    This paper presents the highlights of the Special Education Faculty Needs Assessment Study (SEFNA). Actions taken after the release of The 2001 Faculty Shortage Study demonstrate that supply-and-demand imbalances can be improved. The projected shortage of special education faculty will directly and negatively affect students with disabilities and…

  19. Lessons learnt from ten performance assessment studies

    International Nuclear Information System (INIS)

    The management of radioactive wastes and, in particular, the safety assessment of radioactive waste disposal systems are areas of high priority in the programme of the OECD Nuclear Energy Agency (NEA). In 1994, a Working Group was set up under the PAAG (Performance Assessment Advisory Group) on Integrated Performance Assessments of Deep Repositories (IPAG). The aim of the group is to provide a forum for informed discussion on performance assessment (PA), and to examine the overall status of PA and specific issues identified by the group and the PAAG. This document presents the report of a first phase of work completed in December 1996 and is expected to be of most interest to practitioners of repository PA and those with an interest in technical review of PA studies. (K.A.)

  20. Retardation mechanism studies for performance assessments

    International Nuclear Information System (INIS)

    Performance assessments of geological repositories for nuclear waste require information about how possibly escaping radionuclides will be transported through the bedrock. Retardation mechanism studies provide an important part of the database required. So far Finnish performance assessments have considered sorption and matrix diffusion as retardation mechanisms. In this report we discuss how the data supplied by experimental retardation mechanism studies meet those required by performance assessments in the Finnish case. Experimental structural studies on small-scale pore network are discussed in detail. The C-14-PMMA method and helium-gas methods provide porosity, diffusivity and permeability data. The effort within the Palmottu natural analogue project that aimed to locate large-scale flow channels is described briefly. Specific retardation mechanism studies are discussed. The laboratory studies cover column experiments and anion exclusion studies. Column experiments provide data on sorption and matrix diffusion. The natural analogue studies cover work done in the Palmottu, the Haemeenlinna boulder, and the Haestholmen projects. Studies at Palmottu provide in situ data about sorption and matrix diffusion. This review indicates that data required by current migration models in performance assessments can be met by existing experimental methods. But the situation changes if more detailed modelling is wanted. In that case, a strategic question must be answered: what is a reasonable level of detail and conceptual rigour in performance assessment modelling, considering the unavoidable overall uncertainties due to long time scales and heterogeneous bedrock? The results obtained so far in natural analogue studies indicate that there is room for improvements in sorption modelling. The current Kd based approach could be supported by parallel mechanistic sorption modelling. It is acknowledged, however, that mechanistic sorption modelling is possible for neither all

  1. Myocardial perfusion assessed by contrast echocardiography and single photon emission computed tomography in the evaluation of patients with acute chest pain and normal electrocardiogram

    International Nuclear Information System (INIS)

    Aim : Evaluation of diagnostic accuracy of myocardial contrast echocardiography (MCE) in comparison with single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia in patients with acute chest pain. Material and Methods : Eighteen patients (pts) with chest pain lasting ≥30 minutes, occurring within 6 hours of emergency room presentation and a normal or no diagnostic electrocardiogram were studied. Pts underwent rest MCE and SPECT. For both exams myocardial perfusion was assessed in the same 7 segments (apical, anterior, inferior, anteroseptal, inferoseptal, lateral and posterior) of left ventricle. A total of 126 segments were analyzed. Images were classified as positive for ischemia if they had a perfusion defect. Coronary angiography was performed if MCE or SPECT images were classified as positive for ischemia or by clinical indication. Otherwise the patients underwent stress SPECT. Significant coronary artery disease (CAD) was defined as ≥70% stenosis in a major coronary artery or its branches. Final diagnosis of an acute coronary event (ACE) was established in the presence of positive findings in MCE or SPECT in addition to significant CAD in the corresponding territory. Kappa statistics were calculated to evaluate the concordance between MCE and SPECT. κ values of ≤0.4, >0.4 and >0.7 indicate fair, good and excellent agreement, respectively. Results: Thirteen out of 18 pts underwent coronary angiography (seven pts had positive findings on SPECT, 2 on MCE, 2 on both exams and 1 had clinical indication). Significant CAD was detected on six. Five pts underwent stress SPECT and no perfusion defect was detected. Therefore, six pts (33.3%) had an ACE and 12 (66.6%) had not. There were no statistical differences between groups according to age, gender, duration of pain, free pain interval, presence of risk factors and antecedents. Concordance between MCE and SPECT for evaluation of perfusion defects showed a ? coefficient of 0

  2. Assessment of joint pain in teenagers with juvenile arthritis

    Directory of Open Access Journals (Sweden)

    T A Shelepina

    2009-01-01

    Full Text Available Assessment of joint pain in teenagers with juvenile arthritisObjective. To assess mean total pain score in teenagers with juvenile arthritis (JA and its values in groups differing on sex, variant of course, activity measures, degree of functional disturbances. To assess advisability of application of these parameters in real clinical practice. Material and methods. 73 pts with JA (mean age 14,7±1,7 years, mean disease duration7,2±4,4 years were included. 18 from them had systemic, 42 – polyarticular and 13 – olygoarticular variant. 16 pts were examined repeatedly with interval exceeding one year. Total quantity of examinations was 94. 17 pts were examined at admission and at discharge. Pain was measured on visual analog scale (VAS and on McGill Pain Questionnaire (83 examinations including 3 scale: sensor (description of pain, affective (their influence on emotional state and evaluative (verbal assessment of pain intensity. General health assessment on VAS was performed in 59 pts (in 8 from them at admission and at discharge. Summary mean measures and their values in groups differing in sex, course variant, activity measure, functional class at pts admission to and at discharge from the Institute of Rheumatology of RAMS. Statistical treatment was performed with Biomed program(descriptive statistic, χ2, Student’s pared test. Results. Mean pain score on VAS in all teenagers with JA was 31,3±17,3. It was significantlyhigher in boys with systemic variant (in comparison with polyarticular, in pts with ESR elevation above 30, in pts with functional class 3 and higher at admission to the department. Pain score was significantly lower in pts with olygoarticular variant in comparison with mean value and with value in polyarthritis. Pain above 70 mm on VAS was found in pts with polyarticular damage in systemic and polyarticular variants in active phase of the disease and in severe functional disability. Summated (on sensor and affective scales

  3. 6-PTS 并联机器人机构逆向运动学分析与仿真*1%Inverse kinematics analysis and simulation of 6-PTS parallel robot

    Institute of Scientific and Technical Information of China (English)

    张锋涛

    2015-01-01

    Objective—To put forward the algorithm of kinematic relationship between the parallel robot components.Methods—The composite joint of 6-PTS parallel robot's structure was equivalently processed into single DOF (degree of freedom)joint,then D-H (Denavic-Hartenberg)method was used to define the local coordinate system and kinematic parameters of each linkage.Finally mecha-nism constraint equations was established according to the motion equivalence condition and the solu-tion was obtained with reverse homogeneous transformation.Results and Conclusion—The variables of all joint and the position of each linkage were solved successively.On this basis,the influence coeffi-cient theory was utilized to build the transitive relationships of the velocity and acceleration between moving platform and each linkage to provide the basis for the dynamic modeling and control problem of the mechanism.%目的:提出建立并联机器人构件之间运动学关系的算法。方法将6-PTS 并联机器人机构的复合关节等效地处理成单自由度关节,利用 D-H(Denavic-Hartenberg)方法定义每个连杆的局部坐标系和运动学参数,根据运动等同性条件建立机构约束方程,利用逆向齐次变换的方法求解。结果与结论依次求解出全部关节变量和每个连杆的位置表示,在此基础上,应用影响系数理论,建立了动平台与每个连杆之间的速度和加速度的传递关系,为该机构的动力学建模及控制等问题提供了基础。

  4. A Study of Career Planning Assessments

    OpenAIRE

    Firkola, Peter

    2007-01-01

    This paper provides an overview of career planning assessments. Background on key career concepts is first introduced. A number of career planning assessments are then examined. These assessments included reviewing ones personal history, interest inventories, values assessments, personality assessments, and aptitude tests. The importance and limitations of these career assessments is then discussed.

  5. Risk Assessment Study for Storage Explosive

    Directory of Open Access Journals (Sweden)

    S. S. Azhar

    2006-01-01

    Full Text Available In Malaysia, there has been rapidly increasing usage in amount of explosives due to widely expansion in quarrying and mining industries. The explosives are usually stored in the storage where the safety precaution had given high attention. As the storage of large quantity of explosive can be hazardous to workers and nearby residents in the events of accidental denotation of explosives, a risk assessment study for storage explosive (magazine had been carried out. Risk assessment study had been conducted in Kimanis Quarry Sdn. Bhd, located in Sabah. Risk assessment study had been carried out with the identification of hazards and failure scenarios and estimation of the failure frequency of occurrence. Analysis of possible consequences of failure and the effects of blast waves due to the explosion was evaluated. The risk had been estimated in term of fatalities and eardrum rupture to the workers and public. The average individual voluntary risk for fatality to the workers at the quarry is calculated to be 5.75 x 10-6 per person per year, which is much lower than the acceptable level. Eardrum rupture risk calculated to be 3.15 x 10-6 per person per year for voluntary risk. There is no involuntary risk found for fatality but for eardrum rupture it was calculated to be 6.98 x 10-8 per person per year, as given by Asian Development Bank.

  6. Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies

    Institute of Scientific and Technical Information of China (English)

    Jiang-quan ZHOU; Zhi-qiang TANG; Jin-nan ZHANG; Jing-cheng TANG

    2006-01-01

    Aim: To study the in vivo and in vitro metabolism and the effect of para-toluene-sulfonamide (PTS) on cytochrome P450 enzymes (CYP450). Methods: Total C YP450 and microsome protein content were determined after iv pretreatment of rats with PTS. CYP-specific substrates were incubated with rat liver microsomes. Specific CYP isoform activities were determined by using HPLC. CYP chemical inhibitors added to the incubation mixture were used to investigate the principal CYP isoforms involved in PTS metabolism. The effect of PTS on CYP isoforms was investigated by incubating PTS with specific substrates. Results: The groups treated with 33 and 99 mg/kg per d PTS, respectively, had a total CYP content of 0.66±0.17 and 0.60±0.12 nmol/mg. The Km and Vmax were 92.2 μmol/L and 0.0137 nmol/min per mg protein. CYP2C7, CYP2D1 and CYP3A2 might contribute to PTS metabolism in the rat liver. The inhibitory effects of sulfaphenazole and ketoconazole on PTS metabolism were shown to have a mixed mechanism, whereas PTS metabolism was inhibited noncompetitively by quinidine. PTS had little effect on the activities of the selected CYP isoforms. Conclusion: Generally speaking, it is relatively safe for PTS to be co-administered with other drugs. However, care should be taken when administering PTS with CYP inhibitors and the substrates of CYP2C, CYP2D and CYP3A.

  7. Analytical Similarity Assessment in Biosimilar Studies.

    Science.gov (United States)

    Chow, Shein-Chung; Song, Fuyu; Bai, He

    2016-05-01

    For assessment of biosimilarity, the US Food and Drug Administration (FDA) recommends a stepwise approach for obtaining the totality-of-the-evidence for demonstrating biosimilarity between a proposed biosimilar product and an innovative (reference) biological product. The stepwise approach starts with analytical studies for functional and structural characterization at various stages of manufacturing process of the proposed biosimilar product. Analytical similarity assessment involves identification of critical quality attributes (CQAs) that are relevant to clinical outcomes. FDA proposes first classifying the identified CQAs into three tiers according to their criticality or risking ranking relevant to clinical outcomes and then performing equivalence test (for CQAs in Tier 1), quality range approach (for CQAs in Tier 2), and raw data or graphical presentation (for CQAs in Tier 3) for obtaining totality-of-the-evidence for demonstrating biosimilarity between the proposed biosimilar product with the reference product. In practice, some debatable issues are evitably raised due to this complicated process of analytical similarity assessment. In this article, these debatable are described and discussed. PMID:26873509

  8. Thermal hydraulic analyses of accidents associated with coolant leak from the primary circuit through a hole 10 mm equivalent diameter for the needs of PTS

    International Nuclear Information System (INIS)

    The conservative assumptions of the analyses were oriented towards a worsening of the process with respect to the pressurized thermal shock (PTS). Four variants were treated, viz. leaks from the cold or hot leg, each at the rated power or zero power. Since the temperature of water supplied to the primary circuit by the emergency core cooling system is an important parameter with respect to a PTS, the calculations were performed by the iterative procedure: the basic thermal hydraulic calculation was performed by the RELAP5/MOD3.2.1 code which calculates the behaviour of the primary and secondary circuits, whereas the MELCOR code was used to calculate the behaviour of the parameters in the hermetic rooms. The calculation by the RELAP code was then repeated using data from the MELCOR calculations. Interventions by the reactor operators were also considered. (P.A.)

  9. ANALISIS DAMPAK OTONOMI DAERAH TERHADAP STRATEGI PENGEMBANGAN PERGURUAN TINGGI SWASTA (PTS) DI KABUPATEN SLEMAN

    OpenAIRE

    Rudy Badrudin

    2008-01-01

    This research analyze the effect of regional autonomy to the interest of college’s student candidate to continue studying in Sleman Regency which research’s samples for major program’s chosen was Accounting, Management, and Economics in UII, UAJY, UPNVY, and STIE YKPN. The result of research with Boston Consulting Group (BCG) Matrix shows that each major program in four universities and college was in different quadrant. Therefore, each university and college has to choose different developme...

  10. ANALISIS DAMPAK OTONOMI DAERAH TERHADAP STRATEGI PENGEMBANGAN PERGURUAN TINGGI SWASTA (PTS DI KABUPATEN SLEMAN

    Directory of Open Access Journals (Sweden)

    Rudy Badrudin

    2008-12-01

    Full Text Available This research analyze the effect of regional autonomy to the interest of college’s student candidate to continue studying in Sleman Regency which research’s samples for major program’s chosen was Accounting, Management, and Economics in UII, UAJY, UPNVY, and STIE YKPN. The result of research with Boston Consulting Group (BCG Matrix shows that each major program in four universities and college was in different quadrant. Therefore, each university and college has to choose different development strategic specifically even for each major programs in each university and college, so that the major programs in four universities and college in Sleman Regency could grow and rise.

  11. Integrated Operations Architecture Technology Assessment Study

    Science.gov (United States)

    2001-01-01

    As part of NASA's Integrated Operations Architecture (IOA) Baseline, NASA will consolidate all communications operations. including ground-based, near-earth, and deep-space communications, into a single integrated network. This network will make maximum use of commercial equipment, services and standards. It will be an Internet Protocol (IP) based network. This study supports technology development planning for the IOA. The technical problems that may arise when LEO mission spacecraft interoperate with commercial satellite services were investigated. Commercial technology and services that could support the IOA were surveyed, and gaps in the capability of existing technology and techniques were identified. Recommendations were made on which gaps should be closed by means of NASA research and development funding. Several findings emerged from the interoperability assessment: in the NASA mission set, there is a preponderance of small. inexpensive, low data rate science missions; proposed commercial satellite communications services could potentially provide TDRSS-like data relay functions; and. IP and related protocols, such as TCP, require augmentation to operate in the mobile networking environment required by the space-to-ground portion of the IOA. Five case studies were performed in the technology assessment. Each case represented a realistic implementation of the near-earth portion of the IOA. The cases included the use of frequencies at L-band, Ka-band and the optical spectrum. The cases also represented both space relay architectures and direct-to-ground architectures. Some of the main recommendations resulting from the case studies are: select an architecture for the LEO/MEO communications network; pursue the development of a Ka-band space-qualified transmitter (and possibly a receiver), and a low-cost Ka-band ground terminal for a direct-to-ground network, pursue the development of an Inmarsat (L-band) space-qualified transceiver to implement a global, low

  12. Hydrogen Mixing Studies (HMS) assessment manual

    International Nuclear Information System (INIS)

    This report documents some calculations performed to assess the Hydrogen Mixing Studies (HMS) code. Results are presented first for some analytical test problems, including laminar flow and mass diffusion. The von Karman vortex street problem and the Sandia FLAME Facility and Heiss Dampf Reaktor (HDR) containment facility test problems are then discussed. For the analytical problems, the code gave results that agree exceptionally well with the analytical solutions. Calculations for the von Karman vortex street problem were performed at selected Reynolds numbers for several obstacle types. The computed flow patterns agree well with experimental observations-specifically the occurrence of a vortex street (double row of vortices) above a critical Reynolds number. Calculations for the von Karman vortex street problem were performed at selected Reynolds numbers for several obstacle types. The computed flow patterns agree well with experimental observations-specifically the occurrence of a vortex street (double row of vortices) above a critical Reynolds number. The last assessment problem involves modeling the experiment T31.5. The experiment was carried out in the HDR containment building, which is a large, multi-compartment facility (11 300 m3 free volume in 72 compartments). In the experiment, a steam-water mixture was first injected into the containment to simulate a large-break blowdown of a pressure vessel, and then superheated steam was injected that was followed by a release of helium-hydrogen light gas. The calculated results (pressure, temperature, and gas concentrations) agree reasonably well with the experimental data

  13. Geology, Surficial - SAND_ILITH_PTS_IN: Total Thickness of Sand and Gravel in Indiana, Derived from the iLITH Water-Well Database (Indiana Geological Survey, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — SAND_ILITH_PTS_IN is a point shapefile that shows total thickness of sand, as derived from logs of water wells in the state of Indiana. (It presents the source data...

  14. 用部分相关-PTS方法降低OFDM系统的PAPR%Reduction of the PAPR of OFDM systems by partial-correlation-PTS method

    Institute of Scientific and Technical Information of China (English)

    贾莹莹; 杨霖; 王田; 胡武君

    2014-01-01

    文章介绍了降低 OFDM (正交频分复用)系统PAPR (峰均功率比)的各种技术,对PTS (部分传输序列)技术进行了改进,提出了部分相关-PTS方法。该方法的基本思想是经过基带调制数据分割之后,使得除第一个数据块之外的其他每一个数据块分别与第一个数据块做互相关运算,然后按照传统PTS方法继续处理部分相关的数据子块。在接收端,根据每一个子块(第一个子块除外)与第一个子块互相关值的正负来判断该子块所乘的旋转相位,无需传输边带信息就可以恢复出原始信号。仿真结果验证了该方法的有效性。%This paper introduces various technologies for the reduction of the Peak-to-Average Power Ratio (PAPR)of Orthog-onal Frequency Division Multiplexing (OFDM)systems,modifies the conventional Partial Transmit Sequence (PTS)technolo-gy and proposes a partial-correlation-PTS method.The fundamental idea of this method is that after the original modulated fre-quency domain signals are divided into several data blocks,every other data block than the first one does cross-correlation cal-culation with the first data block and then continue to handle partial-correlation data subblocks in accordance with the conven-tional PTS method.At the receiver end,the multiplied rotation phase of each data subblock except the first one is decided ac-cording to the positive or negative property of the cross-correlation value of that subblock with the first data subblock.Thus the original signals can be recovered without transmitting sideband information.The effectiveness of the partial-correlation-PTS method is verified by the simulation results.

  15. Assessment in translation studies : research needs

    OpenAIRE

    Martínez, Nicole; Hurtado Albir, Amparo

    2001-01-01

    On the whole, most research into assessment in translation only concentrates on one area — evaluation of translations of literary and sacred texts — and other areas are ignored. In fact, this field of research includes two other areas, each with its own characteristics: assessment of professionals at work and assessment of trainee translators.Starting with this presupposition, we describe the three areas and analyze the notion of translation assessment, so as to define the characteristics of ...

  16. Assessment of HICO data for Coastal Studies

    Science.gov (United States)

    Singh, R. B.; Chauhan, P.

    2014-12-01

    Coastal waters, in particular, are the regions of high productivity and biodiversity. Detailed investigations of the variability within them can aid in understanding many biogeochemical processes. With the advent of hyperspectral remote sensing having large number of closely spaced channels and highly improved signal-to-noise ratio (SNR), the coastal applications are expected to increase and improve. In India, very less work is done in the field of coastal studies, let alone using hyperspectral remote sensing. HICO, onboard ISS, is the most recent addition to this family of instruments. So, a pilot study was conducted to assess HICO data for coastal studies especially in deriving the shallow water bathymetry estimates. The methodology for deriving bathymetry estimates is based on the different responses of shallow-water reflectance on depth and substrate type because with decreasing water depth in case 2 waters, the spectral contributions arriving from pure water reduce while from other OCAs increase. This variability is typically higher in the wavelength range 480 to 610 nm. Using this wavelength range, bathymetric estimates were made at pixel level. Bathymetry estimates were found to vary from 1 m to >12 m. Spectral variability is clearly observed in the continuum removed spectral plots from waters of different depths and is reported in this paper.

  17. Hegemonic Masculinity in Sport Education: Case Studies of Pre-Service Physical Education Teachers with Teaching Orientations

    Science.gov (United States)

    Chen, YuChun; Curtner-Smith, Matthew D.

    2015-01-01

    Previous research had indicated that pre-service teachers (PTs) with coaching orientations reinforced sexism and masculine bias while employing the sport education (SE) model. The purpose of the current study was to examine whether or not and the degree to which SE delivered by PTs with teaching orientations served to combat or reinforce sexism…

  18. System Losses and Assessment Trade Study

    International Nuclear Information System (INIS)

    This Advanced Fuel Cycle Initiative (AFCI) study has developed new analysis methods to examine old and new technology options toward the goal of improving fuel cycle systems. We have integrated participants and information from AFCI Systems Analysis, Transmutation Fuels, Separations, and Waste Form Campaigns in the Systems Losses and Assessment Trade Study. The initial objectives of this study were to (1) increase understanding of system interdependencies and thereby identify system trade-offs that may yield important insights, (2) define impacts of separations product purity on fuel manufacture and transmutation reactivity, (3) define impacts from transuranic (TRU) losses to waste, (4) identify the interrelationships involved in fuels and separations technology performance, and (5) identify system configuration adjustments with the greatest potential for influencing system losses. While bounding and analyzing this initial problem, we also identified significantly higher-level programmatic drivers with broad implications to the current fuel cycle research charter and the general issue of a DOE complex wide need for a comprehensive and integrated nuclear material management as addressed by the new DOE Order 410.2 titled 'Management of Nuclear Materials'. The initial modeling effort developed in this study for a much smaller subset of material (i.e., commercial fuel) and a selected transmutation scheme (i.e., fast reactor recycling) is a necessary first step towards examining a broader set of nuclear material management options, dispositioning strategies and integrated waste management options including potential areas of research leverage. The primary outcome from this initial study has been an enhanced integration among Campaigns and associated insights and analysis methods. Opportunities for improved understanding between the groups abound. The above lanthanide-actinide example highlights the importance of evaluating options via integration across the Campaigns

  19. System Losses and Assessment Trade Study

    Energy Technology Data Exchange (ETDEWEB)

    David Shropshire; Steve Piet; Nick Soelberg; Robert Cherry; Roger Henry; David Meikrantz; Greg Teske; Eric Shaber; Candido Pereira

    2009-09-01

    This Advanced Fuel Cycle Initiative (AFCI) study has developed new analysis methods to examine old and new technology options toward the goal of improving fuel cycle systems. We have integrated participants and information from AFCI Systems Analysis, Transmutation Fuels, Separations, and Waste Form Campaigns in the Systems Losses and Assessment Trade Study. The initial objectives of this study were to 1) increase understanding of system interdependencies and thereby identify system trade-offs that may yield important insights, 2) define impacts of separations product purity on fuel manufacture and transmutation reactivity, 3) define impacts from transuranic (TRU) losses to waste, 4) identify the interrelationships involved in fuels and separations technology performance, and 5) identify system configuration adjustments with the greatest potential for influencing system losses. While bounding and analyzing this initial problem, we also identified significantly higher-level programmatic drivers with broad implications to the current fuel cycle research charter and the general issue of a DOE complex wide need for a comprehensive and integrated nuclear material management as addressed by the new DOE Order 410.2 titled “Management of Nuclear Materials”. The initial modeling effort developed in this study for a much smaller subset of material (i.e., commercial fuel) and a selected transmutation scheme (i.e., fast reactor recycling) is a necessary first step towards examining a broader set of nuclear material management options, dispositioning strategies and integrated waste management options including potential areas of research leverage. The primary outcome from this initial study has been an enhanced integration among Campaigns and associated insights and analysis methods. Opportunities for improved understanding between the groups abound. The above lanthanide-actinide example highlights the importance of evaluating options via integration across the Campaigns

  20. Practical Education through Risk Assessment Case Studies

    Science.gov (United States)

    Tokai, Akihiro

    Although, the staff for assessing environmental risk of chemicals is required in individual units of industrial sectors, there are very few systemic academic curriculums on risk assessment of chemicals in Japanese institutions of higher education. In order to meet such a social needs, Osaka University opened a limited-period program of environmental risk management for both students and working people in 2005. The author describes the contribution of his experience in offering a course on environmental risk assessment of chemicals as a part of the program. The course afforded students a kind of practical training for risk assessment. This paper also involves what to do for strengthening the education activity of risk assessment.

  1. 恰希玛核电厂压力容器各关键部位在PTS瞬态下的温度场研究%Research on PTS Transient Temperature Field of Key Position of RPV for Chashma Nuclear Power Plant

    Institute of Scientific and Technical Information of China (English)

    左巧林; 秋穗正; 王明军

    2016-01-01

    The pressurized thermal shock (PTS) in the assessment of life extension of a nuclear power plant should be paid much attention to .For Chashma NPP No .1 unit ,a complete CFD model for RPV and its internals was established .Coolant velocity and temperature fields in RPV were simulated during normal state ,and the results are con-sistent with experimental data . The coolant thermal-hydraulic characteristics in the RPV nozzle and the downcomer under SGTR transient were also studied in detail .The results were compared with the calculation results by RELAP5 code , and the good agreement is achieved between them .The present research could be useful for the calcu-lation and analysis in RPV aging management evaluation .%承压热冲击现象在核电厂延寿评估中应被重点关注.本文针对恰希玛核电厂1号机组的压力容器及堆内构件建立了完整的C FD模型,计算了正常工况下压力容器内冷却剂的速度场和温度场分布,计算结果与试验结果符合良好.本文详细研究了蒸汽发生器传热管破裂事故工况下压力容器接管及下降段中冷却剂的热工水力特性,并将计算结果与RELAP5计算结果进行对比,结果表明二者符合良好.本文研究可为反应堆压力容器老化管理评估的计算分析工作提供重要参考.

  2. Information Technology Assessment Study: Full Report

    Science.gov (United States)

    Peterson, John (Editor)

    2002-01-01

    A team was formed to assess NASA Office of Space Science (OSS) information technology research and development activities. These activities were reviewed for their relevance to OSS missions, for their potential for using products better supplied by industry or other government agencies, and for recommending an information technology (IT) infusion strategy for appropriate products for OSS missions. Assessment scope and methodology are presented. IT needs and interests for future OSS missions and current NASA IT research and development (R&D) are discussed. Non-NASA participants provide overviews of some of their IT R&D programs. Implementation and infusion issues and the findings and recommendations of the assessment team are presented.

  3. Assessing English proficiency for university study

    CERN Document Server

    Read, John

    2015-01-01

    This book focuses on strategies and procedures for assessing the academic language ability of students entering an English-medium university, so that those with significant needs can have access to opportunities to enhance their language skills.

  4. 一种降低OFDM信号PAPR的改进PTS方法%A kind of reducing PAPR of OFDM signal using improved PTS method.

    Institute of Scientific and Technical Information of China (English)

    曾庆芳; 何选森

    2012-01-01

    部分传输序列(PTS)方法通过选择合适的相位序列以降低信号峰值出现的概率,该方法不会使信号发生畸变.但是传统的PTS技术计算复杂度非常大,需遍历所有可选的相位因子,其计算量随分割子序列数按指数增长.提出了一种正倒二叉树多层相位序列方法,该方法通过对称的树形搜索,搜索出最优的相位序列.仿真结果表明,该方法大大降低系统的复杂度,同时PAPR得到更好的抑制.%By choosing the appropriate phase sequence, Partial Transmit Sequence(PTS) method reduces the probability of the signal peak, this method does not make the signal distortion. But conventional PTS technique has very large computational complexity, needs to traverse all the optional phase factor, its calculation sequence increases with the number of separate exponential growth. In this paper, a multi-phase sequence method is proposed, which is inverted binary tree. By symmetrical tree searching, this method searches out the optimal phase sequence. Simulation results show that the method reduces the system complexity, while the PAPR has been better suppressed.

  5. Information Technology Assessment Study: Executive Summary

    Science.gov (United States)

    Peterson, John (Editor)

    2002-01-01

    A team was formed to assess NASA Office of Space Science (OSS) information technology research and development activities. These activities were reviewed for their relevance to OSS missions, for their potential for using products better supplied by industry or other government agencies, and for recommending an IT infusion strategy for appropriate products for OSS missions. Assessment scope and methodology and the findings and recommendations of OSS IT users and providers are presented.

  6. Student Perceptions of Peer Assessment: An Interdisciplinary Study

    Science.gov (United States)

    Planas Lladó, Anna; Soley, Lídia Feliu; Fraguell Sansbelló, Rosa Maria; Pujolras, Gerard Arbat; Planella, Joan Pujol; Roura-Pascual, Núria; Suñol Martínez, Joan Josep; Moreno, Lino Montoro

    2014-01-01

    Peer assessment provides students with multiple benefits during their learning process. The aim of our study is to examine students' perception of peer assessment. Questionnaires were administered before and after the peer-assessment process to 416 students studying 11 different subjects in four different fields taught at the University of…

  7. 不同叠加训练序列PTS降低PAPR性能比较%Comparison of Different Superimposed Training Sequence PTS for PAPR Reduction

    Institute of Scientific and Technical Information of China (English)

    张杰; 罗仁泽; 党煜蒲; 牛娜; 李芮; 杨娇

    2014-01-01

    Partial Transmit Sequences ( PTS) is an efficient scheme for Peak-to-Average Power Ratio ( PAPR) reduction in Orthogonal Frequency Division Multiplexing ( OFDM) system,but the performance of reduction is limited and the sideband information occupied the spectrum resources. Based on the traditional PTS method and the method of superimposed training PTS,the performance of PAPR reduc-tion from the superposition of different training sequences and the different training sequences for phase rotation factors and power alloca-tion factor is analyzed. The simulation results show that the better autocorrelation superimposed training sequence has the better capacity of PAPR reduction,different training sequences for phase rotation factor has little effect on PAPR reduction,and when using Hadama code and the power allocation factor is greater than 0. 15,the ability of PAPR reduction is enhanced. In this scheme,the training sequences can not only use for synchronization and channel estimation,but also promote the band efficiency and PAPR reduction ability of the system.%部分传输序列(PTS)能有效降低正交频分复用(OFDM)系统的峰均功率比(PAPR),但是其存在降低性能有限和边带信息占用频谱资源的问题。文中在传统PTS方法的基础上,基于叠加训练序列PTS降低PAPR的方法,分析了叠加不同训练序列、不同训练序列作相位旋转因子及功率分配因子对降低PAPR性能的影响。仿真结果表明:叠加自相关性较好的训练序列,降低PAPR的能力更强;不同训练序列作相位旋转因子时,对降低PAPR的效果影响不大;采用Hadama码、功率分配因子大于0.15时,降低PAPR的能力增强。该方法中的训练序列,不仅可以用于同步﹑信道估计,而且可以降低PAPR,并提高系统频谱利用率。

  8. A New Method for the Detection and Enumeration of Xylitol-resistant (fructose-PTS-) Strains of Streptococcus mutans from Pure Cultures and Human Saliva

    OpenAIRE

    Dréan, M. -F.; Trahan, L.

    2011-01-01

    A simple procedure for the identification and enumeration, in large bacterial populations, of Streptococcus mutans of both xylitol-resistant and xylitol-sensitive phenotypes was developed. Since xylitol-resistant cells have lost the capacity to take up xylitol from the extracellular medium, due to a defect in their fructose-PTS, there is no uptake of [14C]xylitol by these cells whereas the [14C]xylitol taken up by the sensitive cells is used to visualise them by autoradiography. The method wa...

  9. Mutational Inactivation of a Gene Homologous to Escherichia coli ptsP Affects Poly-β-Hydroxybutyrate Accumulation and Nitrogen Fixation in Azotobacter vinelandii

    OpenAIRE

    Segura, Daniel; Espín, Guadalupe

    1998-01-01

    Strain DS988, an Azotobacter vinelandii mutant with a reduced capacity to accumulate poly-β-hydroxybutyrate, was isolated after mini-Tn5 mutagenesis of the UW136 strain. Cloning and nucleotide sequencing of the affected locus revealed a gene homologous to Escherichia coli ptsP which encodes enzyme INtr, a homologue of enzyme I of the phosphoenol pyruvate-sugar phosphotransferase system with an N-terminal domain similar to the N-terminal domain of some NifA proteins. Strain DS988 was unable to...

  10. Interaction between users and IoT clusters:Moving towards an Internet of People, Things and Services (IoPTS)

    OpenAIRE

    Shinde, Gitanjali; Olesen, Henning

    2015-01-01

    The Internet of Things (IoT) is paving the way for a vast number of objects in our environment to react, respond and work autonomously as and when required and as per their capability, role and position. They will be able to announce and offer their services to the users, and together this will enable the vision of an "Internet of People, Things and Services" (IoPTS). Application areas for IoT include smart cities, smart homes, environmental control, security & emergency, retail, logistic...

  11. Preliminary assessment of the effects of biaxial loading on reactor pressure vessel structural-integrity-assessment technology

    International Nuclear Information System (INIS)

    Effects of biaxial loading on shallow-flaw fracture toughness were studied to determine potential impact on structural integrity assessment of a reactor pressure vessel (RPV) under pressurized thermal shock (PTS) transient loading and pressure-temperature (PT) loading produced by reactor heatup and cooldown transients. Biaxial shallow-flaw fracture-toughness tests results were also used to determine the parameter controlling fracture in the transition temperature range, and to develop a related dual-parameter fracture-toughness correlation. Shallow-flaw and biaxial loading effects were found to reduce the conditional probability of crack initiation by a factor of nine when the shallow-flaw fracture-toughness KJc data set, with biaxial-loading effects adjustments, was substituted in place of ASME Code KIc data set in PTS analyses. Biaxial loading was found to reduce the shallow-flaw fracture toughness of RPV steel such that the lower-bound curve was located between ASME KIc and KIR curves. This is relevant to future development of P-T curve analysis procedures. Fracture in shallow-flaw biaxial samples tested in the lower transition temperature range was shown to be strain controlled. A strain-based dual-parameter fracture-toughness correlation was developed and shown to be capable of predicting the effect of crack-tip constraint on fracture toughness for strain-controlled fracture

  12. Energy security assessment framework and three case-studies

    OpenAIRE

    CHERP, ALEH; Jewell, Jessica

    2013-01-01

    This chapter provides a novel framework for assessing energy security and illustrates its application by the Global Energy Assessment, the IEA Model for Short-term energy security and in several studies of long-term global energy security.

  13. Shift manager workload assessment - a case study

    International Nuclear Information System (INIS)

    In early 2003, Bruce Power restarted two of their previously laid up units in the Bruce A generating station, Units 3 and 4. However, due to challenges relating to the availability of personnel with active Shift Manager licenses, an alternate shift structure was proposed to ensure the safe operation of the station. This alternate structure resulted in a redistribution of responsibility, and a need to assess the resulting changes in workload. Atomic Energy of Canada Limited was contracted to perform a workload assessment based on the new shift structure, and to provide recommendations, if necessary, to ensure Shift Managers had sufficient resources available to perform their required duties. This paper discusses the performance of that assessment, and lessons learned as a result of the work performed during the Restart project. (author)

  14. Field Test of ATHEANA (A Technique for Human Event Analysis) in Pressurised Thermal Shock Probabilistic Risk Assessments

    International Nuclear Information System (INIS)

    The U.S. Nuclear Regulatory Commission (USNRC) is currently developing the technical basis for potentially modifying the Pressurised Thermal Shock (PTS) screening criteria specified in Title 10 Part 50.61 of the U.S. Code of Federal Regulations. As part of this effort, PTS probabilistic risk assessments (PRAs) are being performed by the USNRC and its contractors, for two U.S. nuclear power plants, with assistance by the respective utilities. Two other plant analyses will also be performed as part of the PTS work, but are not the subject of this paper. These latter two analyses are being performed by industry and will be reviewed by the USNRC for inclusion into the entire effort. The ATHEANA methodology is being applied to address the human reliability portion of the two USNRC analyses in a way that is also significantly interactive with the accident sequence and system modelling portions of the work. This paper discusses the results to date of the application of ATHEANA in these PTS analyses, including consideration of possible relevant errors of commission. The field test of ATHEANA on this project has served two purposes. One is to use it in developing technical analyses to address and solve a particular issue; i.e., the risk of PTS. The results of these analyses will be used by the USNRC to decide whether or not the PTS screening criteria should be modified. The second purpose is to test the use of ATHEANA in a real application to determine strengths and weaknesses of the method, and how it might be improved. With regard to the first purpose, the PTS project is one where a current screening criteria may be relaxed. Before that can be done, the NRC must be sure that it is safe to do so, and to the extent the specific risk values affect that decision, those values must be able to withstand public scrutiny. Since the ATHEANA process requires the analysts to identify potential vulnerabilities and challenging scenario deviations associated with a human action, and to

  15. Research on structural integral assessment of cylinders with circumference cracks under pressurized thermal shock based on probabilistic fracture mechanics

    International Nuclear Information System (INIS)

    Background: Many investigations on the structural integrity assessment of reactor pressure vessel (RPV) under the pressure thermal stress (PTS) conditions have been performed. Probabilistic fracture mechanics (PFM) technique has been used for RPV PTS analysis since 1980. However, research on the structure integrity assessment techniques using the PFM method is insufficient in China to support the application of the method to be used for assessment of RPV under PTS conditions. Purpose: To gain the effective right assessment approach applied to Chinese RPV against PTS. Methods: Thermal stress distribution along the cylinder wall-thickness under PTS is firstly evaluated by FE in order to get the corresponding stress intensity factors (SIF) and to validate them with some available SIF solutions. The PFM analyses based on crack initiation are then performed under conditions of the crack size, fracture toughness and material yield stress. Both linear elastic fracture mechanics and R6 method are used in the analyses, and the sensitivity of uncertainties as well as the effect of the assessment method is discussed. Monte Carlo simulation is used to calculate the failure probability. Results: preliminary software is developed to perform the assessment for PTS analysis. The failure probability with R6 method is a little higher than with the linear elastic fracture mechanics approach. The effect of reference nil-ductility transition temperature RTNDT on the failure probability is more significant than other factors. Conclusions: Many uncertainties should be considered in RPV PTS analysis with PFM approach in the further, including the input parameters and failure models. Low RTNDT can extend the time of failure, and reduce the failure probability. (authors)

  16. Cooperative Student Assessment Method: an Evaluation Study

    Directory of Open Access Journals (Sweden)

    Antonella Grasso

    2006-06-01

    Full Text Available Training through the Internet poses a series of technical problems and pedagogical issues. Traditional training is not indiscriminate but takes on different forms according to the needs of the subject being trained and the context where such training occurs. In order to make the systems adaptable in this way, a model of the student’s characteristics - the student model - has to be set up, maintained and updated. However, there are many difficulties involved in obtaining sufficient information to create an accurate student model. One way to solve this problem is to involve students in the student modeling process, stimulating them to provide the necessary information by means of a dialog in which the student and system build the student model according to a collaborative process. The present work describes a cooperative student modeling method (Cooperative Student Assessment - CSA which builds a joint system-student assessment of student’s activities on the basis of the student’s self-assessment ability estimation and a prototype system for children, addressing the learning of fractions, in which CSA is implemented. The article also reports the result of an experimentation carried out with learners attending primary school aiming at evaluating the effectiveness of involving students in the assessment process by comparing two versions of the same system: one using cooperative student modeling and the other the traditional overlay model.

  17. Assessment Leaders' Perspectives of Institutional Cultures of Assessment: A Delphi Study

    Science.gov (United States)

    Fuller, Matthew; Henderson, Susan; Bustamante, Rebecca

    2015-01-01

    Institutional cultures of assessment are praised as beneficial to student learning. Yet, extant studies have not explored the theoretical foundations and pragmatic approaches to shaping cultures of assessment. The researchers used the Delphi method to explore 10 higher education assessment leaders' attitudes and theoretical perspectives regarding…

  18. Alflutop clinical efficacy in vertebral osteochondrosis (12-mohth study

    Directory of Open Access Journals (Sweden)

    V N Hodyrev

    2005-04-01

    Full Text Available Objective. To study clinical efficacy of aiflutop (A in lumbar osteochondrosis (LO with chronic back pain syndrome. Material and Methods. 32 pts with LO were included. 14 from them (group 1 during a year received 2 courses of A intramuscular injections (I ml/day, 30 ml total and nonsteroidal anti-inflammatory drugs (NSAIDs if necessary. 18 pts (group 2 received NSAIDs only. Clinical examination of pts was performed at the stert of the study, before and after each A course and in 3 months after the last course. Results. Pain in the spine at rest and forward bending significantly decreased in group 1 pts (p<0,05 after each A course. Full pain disappearance after the first A course was achieved in 7,1% and after the second course - in 35,7% of group I pts and was not shown in control group. Significant stepped decrease of Thomayer's test value (p<0,00l was also shown in group 1: 3,6 times decrease in comparison with baseline was achieved in 3 months after completion of treatment with A. During treatment period these pts showed 2-2,5 times increase of static and dynamic spine load (according to Vxdel chronic inability index. 42,9% of group I pts stopped NSAIDs after A treatment completion. Only 5,6% of control group pts stopped NSAIDs during follow up. A tolerability was good. It can be combined with any other medications the pts received due to comorbid diseases.

  19. Making Room for Formative Assessment Processes: A Multiple Case Study

    Science.gov (United States)

    McEntarffer, Robert E.

    2012-01-01

    This qualitative instrumental multiple case study (Stake, 2005) explored how teachers made room for formative assessment processes in their classrooms, and how thinking about assessment changed during those formative assessment experiences. Data were gathered from six teachers over three months and included teacher interviews, student interviews,…

  20. Clinical experimental stress studies: methods and assessment.

    Science.gov (United States)

    Bali, Anjana; Jaggi, Amteshwar Singh

    2015-01-01

    Stress is a state of threatened homeostasis during which a variety of adaptive processes are activated to produce physiological and behavioral changes. Stress induction methods are pivotal for understanding these physiological or pathophysiological changes in the body in response to stress. Furthermore, these methods are also important for the development of novel pharmacological agents for stress management. The well-described methods to induce stress in humans include the cold pressor test, Trier Social Stress Test, Montreal Imaging Stress Task, Maastricht Acute Stress Test, CO2 challenge test, Stroop test, Paced Auditory Serial Addition Task, noise stress, and Mannheim Multicomponent Stress Test. Stress assessment in humans is done by measuring biochemical markers such as cortisol, cortisol awakening response, dexamethasone suppression test, salivary α-amylase, plasma/urinary norepinephrine, norepinephrine spillover rate, and interleukins. Physiological and behavioral changes such as galvanic skin response, heart rate variability, pupil size, and muscle and/or skin sympathetic nerve activity (microneurography) and cardiovascular parameters such as heart rate, blood pressure, and self-reported anxiety are also monitored to assess stress response. This present review describes these commonly employed methods to induce stress in humans along with stress assessment methods. PMID:26020552

  1. Assessing biofuel crop invasiveness: a case study.

    Directory of Open Access Journals (Sweden)

    Christopher Evan Buddenhagen

    Full Text Available BACKGROUND: There is widespread interest in biofuel crops as a solution to the world's energy needs, particularly in light of concerns over greenhouse-gas emissions. Despite reservations about their adverse environmental impacts, no attempt has been made to quantify actual, relative or potential invasiveness of terrestrial biofuel crops at an appropriate regional or international scale, and their planting continues to be largely unregulated. METHODOLOGY/PRINCIPAL FINDINGS: Using a widely accepted weed risk assessment system, we analyzed a comprehensive list of regionally suitable biofuel crops to show that seventy percent have a high risk of becoming invasive versus one-quarter of non-biofuel plant species and are two to four times more likely to establish wild populations locally or be invasive in Hawaii or in other locations with a similar climate. CONCLUSIONS/SIGNIFICANCE: Because of climatic and ecological similarities, predictions of biofuel crop invasiveness in Hawaii are applicable to other vulnerable island and subtropical ecosystems worldwide. We demonstrate the utility of an accessible and scientifically proven risk assessment protocol that allows users to predict if introduced species will become invasive in their region of interest. Other evidence supports the contention that propagule pressure created by extensive plantings will exacerbate invasions, a scenario expected with large-scale biofuel crop cultivation. Proactive measures, such as risk assessments, should be employed to predict invasion risks, which could then be mitigated via implementation of appropriate planting policies and adoption of the "polluter-pays" principle.

  2. Exposure Assessment in Cohort Studies of Childhood Asthma

    OpenAIRE

    Arrandale, Victoria H.; Brauer, Michael; Brook, Jeffrey R.; Brunekreef, Bert; Gold, Diane R.; London, Stephanie J.; Miller, J. David; Özkaynak, Halûk; Ries, Nola M.; Sears, Malcolm R; Silverman, Frances S.; Takaro, Tim K

    2010-01-01

    Background The environment is suspected to play an important role in the development of childhood asthma. Cohort studies are a powerful observational design for studying exposure–response relationships, but their power depends in part upon the accuracy of the exposure assessment. Objective The purpose of this paper is to summarize and discuss issues that make accurate exposure assessment a challenge and to suggest strategies for improving exposure assessment in longitudinal cohort studies of ...

  3. Formative peer assessment in a CSCL Environment: A case study

    OpenAIRE

    Prins, F.J.; Sluijsmans, D.M.A.; Kirschner, P.A.; Strijbos, J.-W.

    2005-01-01

    In this case study our aim was to gain more insight in the possibilities of qualitative formative peer assessment in a computer supported collaborative learning (CSCL) environment. An approach was chosen in which peer assessment was operationalized in assessment assignments and assessment tools that were embedded in the course material. The course concerned a higher education case-based virtual seminar, in which students were asked to conduct research and write a report in small multidiscipli...

  4. Remote risk assessment: A case study using SCOPE software

    OpenAIRE

    Demichela, Micaela

    2015-01-01

    A thorough risk assessment requires input from experts in both safety analyses and the system under analysis. The cost of collecting together the required expertise for a short risk assessment may mean that for some small and medium enterprises (SME), the risk assessment is not deemed worthwhile or is completed using a generic form. This is despite the possible safety and performance benefits that can be identified via a thorough risk assessment. This paper presents a case study of a risk ass...

  5. A Formative eAssessment Co-Design Case Study

    OpenAIRE

    Bacigalupo, David; Warburton, Bill; Draffan, E.A.; Zhang, Pei; Gilbert, Lester; Wills, Gary

    2010-01-01

    Formative eAssessment can be very helpful in providing high quality higher education assignments. However, there are obstacles restricting the uptake of formative eAssessment in higher education including both cultural and technical issues. When a university is encouraging the uptake of formative eAssessment internally it is useful to have case studies from academic schools detailing how academics enthusiastic about formative eAssessment have used it in their modules. It is particularly helpf...

  6. 基于PTS缺陷型大肠杆菌构建莽草酸生产菌%Construction of shikimic acid-producing engineered Escherichia coli strains based on ptsHIcrr mutants

    Institute of Scientific and Technical Information of China (English)

    邹永康; 周军智; 孙旭; 蔡亚非; 戴红梅; 李树龙; 周长林; 方宏清

    2011-01-01

    对大肠杆菌芳香族氨基酸合成途径进行代谢流改造,以实现高效的生物制备莽草酸.以磷酸烯醇式丙酮酸-糖磷酸转移酶系统(PTS系统)敲除菌DH5αΔptsHIcrr(DHP)为基础,特异性敲除aroL,ydiB基因并转入受阿拉伯糖诱导表达的T7-RNA聚合酶基因,最终构建一系列产莽草酸宿主菌.再将aroE、aroB、tktA、glk、aroF组成的系列基因串联起来置于质粒上,在T7启动子控制下表达,经摇瓶培养检测得知,不同重组菌产莽草酸能力与对照相比均有明显提高,其中DHPYA-T7/pAOC-TGEFB菌株产量最高,可达到392 mg/L.为进一步构建高表达莽草酸工程菌奠定基础.%Metabolic engineering for aromatic amino acid biosynthesis pathway in Escherichia coli to acquire high-level biosynthesis of shikimic acid was reported. Knockout of aroL, ydiB genes and knock-in of T7-RNA-Polymerase gene which expression was controlled by L-arabinose based on the initial strain DH5α△ptsHlcrr (DHP), resulted in a series of shikimic acid-producing host strains. A series of tandem genes consisting of aroE, aroB, tktA, glk or aroFfbr were controlled by T7 promoter on plasmids were transformed into these host strains. According to the concentration of shikimic acid in shake-flask culture, all the engineered strains displayed high-potentiality compared to the control strain DHP, and the strain DHPYA-T7/pAOC-TGEFB synthesized the highest yield of 392 mg/L of shikimic acid. This study layed a strong foundation for constructing a high-level shikimic acid-producing engineered strain.

  7. A study of reactor vessel integrity assessment

    International Nuclear Information System (INIS)

    The fast neutron fluence at the Reactor Pressure Vessel(RPV) of KNGR designed for 60 years lifetime was calculated by full-scope Monte Carlo simulation for reactor vessel integrity assessment. KNGR core geometry was modeled on a three-dimensional representation of the one-sixteenth of the reactor in-vessel component. Each fuel assemblies were modeled explicitly, and each fuel pins were axially divided into 5 segments. The maximum flux of 4.3 x 1010 neutrons/cm2. sec at the RPV was obtained by tallying neutrons crossing the beltline of inner surface of the RPV

  8. Cumulative assessment : Strategic choices to influence students' study effort

    NARCIS (Netherlands)

    Kerdijk, Wouter; Tio, Rene A.; Mulder, B. Florentine; Cohen-Schotanus, Janke

    2013-01-01

    Background: It has been asserted that assessment can and should be used to drive students' learning. In the current study, we present a cumulative assessment program in which test planning, repeated testing and compensation are combined in order to influence study effort. The program is aimed at hel

  9. Quality Assessment of Internationalised Studies: Theory and Practice

    Science.gov (United States)

    Juknyte-Petreikiene, Inga

    2013-01-01

    The article reviews forms of higher education internationalisation at an institutional level. The relevance of theoretical background of internationalised study quality assessment is highlighted and definitions of internationalised studies quality are presented. Existing methods of assessment of higher education internationalisation are criticised…

  10. Occupational Exposure Assessment in Epidemiological Studies of EMF (invited paper)

    International Nuclear Information System (INIS)

    Numerous epidemiological studies have examined associations between occupational exposures to electric and magnetic fields (EMF) and adult cancers, with a particular focus on leukaemia and brain cancer. Meta-analyses that explored the patterns of these results with a particular emphasis on the qualitative aspects of exposure assessment are reviewed. Comparative analysis of the studies of electric utility employees are presented, along with an assessment of whether methodological differences among the studies might explain reported inconsistencies. Exposure assessment remains a foremost challenge in EMF studies. Most epidemiological studies have relied on magnetic field measurements linked to job titles. However, job titles alone explain only a small amount of variability in exposure. Recent results indicate that magnetic field exposure assessment should consider work environment in addition to job title to reduce exposure misclassification. The paper concludes with a discussion of numerous difficulties in occupational exposure assessment and offers suggestions for research. (author)

  11. The Colorado Plateau coal assessment study area, 2000 (cpstdyg)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This is a coverage of the Colorado Plateau coal assessment study area. The study area outline was drawn on the county lines that most closely outline the...

  12. Continuous Assessment: A Preliminary Study of Student Engagement in the Assessment Process

    OpenAIRE

    Nevin, Edmund; Mageean, Eileen; Llorens, Marisa

    2013-01-01

    This paper provides an objective analysis of student engagement with continuous assessment over a three year period. The results of two groups of students from different stages of a modularised level seven engineering programme were examined. As both groups had taken modules where they studied numerical differentiation, this topic was selected and the corresponding assessment results and attendance of both groups were analysed. Two assessment methods were used to evaluate student engagemen...

  13. GV100 e-assessment pilot study

    OpenAIRE

    Chatzigavriil, Athina; FOLEY, GERALDINE; Fernando, Renuka

    2015-01-01

    This study evaluates the GV100 pilot – a timed, on-campus, invigilated, formative exam at LSE led by Learning Technology and Innovation (LTI) and the Department of Government. The pilot required that students use their own computers and further incorporated a self and peer review process that took place subsequent to the exam. This study investigates how students’ reflections of their own work, combined with the peer review process based on specific marking criteria may affect performance. It...

  14. Dual label single photon emission tomography: A new method to assess redistribution in regional coronary blood flow after nitroglycerin

    Energy Technology Data Exchange (ETDEWEB)

    Liu, P.; Houle, S.; Kimball, B.; Burns, R.J.; Gilday, D.; Weisel, R.D.; Warbick-Cerone, A.; Johnston, L.; McLaughlin, P.R.

    1984-01-01

    The authors have developed a new method to quantitate changes in coronary blood flow (CBF) by single photon emission tomography (SPECT) of dual-labelled intracoronary human albumin microspheres (HAM) before and after an intervention. After initial validation in pigs, the authors studied 20 pts in the cath lab with 10 pts receiving saline to serve as controls, and 10 pts receiving nitroglycerin (NTG). Thermodilution coronary sinus flow (CSF) measurements were made at rest and after each intervention. After pacing to mild angina, serial injections of Tc-99m HAM, 40 ..mu..g of NTG or saline, and In-111 HAM were made in the left main coronary artery. After routine coronary arteriography, the pt underwent dual-peak SPECT with the image slices reconstructed along the longitudinal axis of the heart. Quantitative circumferential profiles were made for each slice by plotting the average count per pixel in each 18/sup 0/ segment of the left ventricle. After correction for absolute coronary blood flow, the difference between the pre- and post-NTG profile was obtained, and a significant change took place if it exceeded 2 S.D. from control. The segments were classified into normal, mildly, moderately or severely comprised territories according to upstream coronary anatomy. Results are presented. The authors conclude: (1) SPECT of intracoronary HAM combined with CSF measurement represents a powerful tool in assessing changes in regional CBF after an intervention; (2) By this method, NTG gave preferential redistribution of CBF to the mild and moderately ischemic zones of the heart.

  15. Bidirectional Relationships between Trauma Exposure and Posttraumatic Stress: A Longitudinal Study of Detroit Residents

    Science.gov (United States)

    Lowe, Sarah R.; Walsh, Kate; Uddin, Monica; Galea, Sandro; Koenen, Karestan C.

    2014-01-01

    Previous research has documented bidirectional relationships between trauma exposure and posttraumatic stress (PTS), such that individuals who are exposed to more traumatic events are at increased risk of developing PTS, and more severe PTS is associated with more subsequent trauma exposure. However, the empirical literature is limited by a lack of longitudinal studies that include continuous measures of PTS, differentiate between assaultive (e.g., sexual assault, being help up or mugged) and non-assaultive (e.g., serious illness, natural disaster) trauma, and focus on urban contexts. The purpose of this study was to fill these gaps through testing three-wave cross-lagged panel models of exposure to assaultive and non-assaultive traumatic events and PTS among a large sample of urban-dwelling adults (N = 1360; 84.4% non-Hispanic Black). In the model including assaultive trauma, more Wave 2 assaultive events were associated with significantly higher Wave 3 PTS. In contrast, in the model including non-assaultive trauma, higher Wave 1 and Wave 2 PTS were associated with more non-assaultive events at Waves 2 and 3, respectively. Taken together, the findings suggest a cycle of adversity wherein urban residents who have experienced assaultive trauma are at risk of more severe PTS, which in turn increases risk for exposure to non-assaultive trauma. This cycle could be tested directly in future studies through models including both types of events. Additional research on the mechanisms that underlie the pathways between PTS and traumatic events could also have implications for policy and practice. PMID:24886002

  16. Methodologic assessment of radiation epidemiology studies

    International Nuclear Information System (INIS)

    Epidemiologic studies of the late effects of ionizing radiation have utilized the entire spectrum of situations in which man has been exposed. These studies have provided insights into the dependence of human effects upon not only dose to target tissues but also other dimensions of exposure, host characteristics, and time following exposure. Over the past three decades studies have progressed from the mere identification of effects to their measurement. Because investigators of human effects have no control over the exposure situation, validity must be sought in the consistency of findings among independent studies and with accepted biologic principles. Because exposure may be confounded with factors that are hidden from view, bias may enter into any study of human exposure. Avoidance of bias and attainment of sufficient power to detect relationships that are real are methodologic challenges. Many methodologic issues, e.g., those associated with the definition and measurement of specific end-points, or with the selection of appropriate controls, permeate epidemiologic work in all fields. Others, especially those concerned with the measurement of exposure, the patterning of events in time after exposure, and the prediction of events beyond the scope of existing observations give radiation epidemiology its distinctive character

  17. A Flexible Order of Assessment: A Case Study

    Directory of Open Access Journals (Sweden)

    Chih-Yang Chen

    2010-01-01

    Full Text Available In this study, we proposed a fuzzy data mining method to improve the situation, which changed the traditional assessment from a strict order into a flexible order. Experimental results have demonstrated the efficiency to reduce the amount of assessed questions. By using fewer questions will increase the participants willingness. Therefore, the high risk groups can be predicted rapidly and do further assessment and counseling.

  18. 降低OFDM系统中PAPR的次优化PTS算法%PAPR Reduction of OFDM System by Sub-Optimal PTS Algorithm

    Institute of Scientific and Technical Information of China (English)

    鲁锦锋; 文武

    2008-01-01

    正交频分复用(OFDM)系统的主要缺点是峰均功率比(PAPR)增大会严重地降低了发射机中高功率放大器(HPA)的效率.部分传输序列(PTS)算法能有效地降低OFDM信号的PAPR概率,但随着PTS中分割子块的增多也带来了高的计算复杂度.为此,文中提出一种新的PTS算法,该算法比传统的穷尽搜寻法具有更佳的性能.仿真结果表明,文中所提PTS算法在降低PAPR相似的情况下,具有更小的计算复杂度.

  19. Assessment, Autonomy, and Elementary Social Studies Time

    Science.gov (United States)

    Fitchett, Paul G.; Heafner, Tina L.; Lambert, Richard

    2014-01-01

    Background/context: In an era of accountability and standardization, elementary social studies is consistently losing its curricular foothold to English/language arts, math, and science instruction. Purpose: This article examines the relationship between elementary teachers' perceptions of instructional autonomy, teaching context, state…

  20. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume of the Systems Design Study contain four Appendixes that were part of the study. Appendix A is an EG ampersand G Idaho, Inc., report that represents a review and compilation of previous reports describing the wastes and quantities disposed in the Subsurface Disposal Area of the Idaho National Engineering Laboratory. Appendix B contains the process flowsheets considered in this study, but not selected for detailed analysis. Appendix C is a historical tabulation of radioactive waste incinerators. Appendix D lists Department of Energy facilities where cementation stabilization systems have been used

  1. Risk Assessment Stability: A Revalidation Study of the Arizona Risk/Needs Assessment Instrument

    Science.gov (United States)

    Schwalbe, Craig S.

    2009-01-01

    The actuarial method is the gold standard for risk assessment in child welfare, juvenile justice, and criminal justice. It produces risk classifications that are highly predictive and that may be robust to sampling error. This article reports a revalidation study of the Arizona Risk/Needs Assessment instrument, an actuarial instrument for juvenile…

  2. Quality of assessments within reach: Review study of research and results of the quality of assessments

    NARCIS (Netherlands)

    Maassen, N.A.M.; Otter, den D.; Wools, S.; Hemker, B.T.; Straetmans, G.J.J.M.; Eggen, T.J.H.M.

    2015-01-01

    Educational tests and assessments are important instruments to measure a student’s knowledge and skills. The question that is addressed in this review study is: “which aspects are currently considered as important to the quality of educational assessments?” Furthermore, it is explored how this infor

  3. Assessment of Correspondent Banks Case Study

    Directory of Open Access Journals (Sweden)

    Abeer F.A.A. Abbadi

    2011-01-01

    Full Text Available Problem statement: This study aims at evaluating corresponding banks in Jordan. Characterizing the goals, instruments and profitability under unfavorable conditions of financial setbacks and unfair competition among banks. Focuses on the feasibility and profitability of Philadelphia Investment Bank in its international trade via its Correspondent banks. Approach: Problems and setbacks shall be screened out; reasoned and appropriate optimal recommendations are to be presented. Results: The study followed the analytical approach and depended on “History Documents” and “In depth Interview” techniques and puts a major emphasis on the fact that correspondent banking has become an essential cornerstone of international business amid the new era of world trade, globalization, external competition and cartels from the major opponents to Jordanian Banks, the main conclusion is realized the importance of correspondent banks in the international trade, so Philadelphia bank benefited from correspondent banks for the cheap cost of market entry and services were tailored to the scale of required locale. But there was no big investment in staff facilities. And there are setbacks in dealing with correspondent banks, such as fund delay in reaching destinations on time. Moreover, Jordanian banks have suffered in general from these correspondent banks because they deal with these correspondent banks individually. Conclusion/Recommendations: The recommendation of the study is, it is the time to consider solidification and forming one financial block, or a sort of cartel and face these correspondent banks in one unit. They are also called for developing collective strategies. Small banks should merge and form huge capital blocks. Another strategy is that Jordanian banks should minimize the reliance on foreign banks and should develop their own, by establishing international branches abroad to help financing their international activities.

  4. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept

  5. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept

  6. Case studies in Bayesian microbial risk assessments

    Directory of Open Access Journals (Sweden)

    Turner Joanne

    2009-12-01

    Full Text Available Abstract Background The quantification of uncertainty and variability is a key component of quantitative risk analysis. Recent advances in Bayesian statistics make it ideal for integrating multiple sources of information, of different types and quality, and providing a realistic estimate of the combined uncertainty in the final risk estimates. Methods We present two case studies related to foodborne microbial risks. In the first, we combine models to describe the sequence of events resulting in illness from consumption of milk contaminated with VTEC O157. We used Monte Carlo simulation to propagate uncertainty in some of the inputs to computer models describing the farm and pasteurisation process. Resulting simulated contamination levels were then assigned to consumption events from a dietary survey. Finally we accounted for uncertainty in the dose-response relationship and uncertainty due to limited incidence data to derive uncertainty about yearly incidences of illness in young children. Options for altering the risk were considered by running the model with different hypothetical policy-driven exposure scenarios. In the second case study we illustrate an efficient Bayesian sensitivity analysis for identifying the most important parameters of a complex computer code that simulated VTEC O157 prevalence within a managed dairy herd. This was carried out in 2 stages, first to screen out the unimportant inputs, then to perform a more detailed analysis on the remaining inputs. The method works by building a Bayesian statistical approximation to the computer code using a number of known code input/output pairs (training runs. Results We estimated that the expected total number of children aged 1.5-4.5 who become ill due to VTEC O157 in milk is 8.6 per year, with 95% uncertainty interval (0,11.5. The most extreme policy we considered was banning on-farm pasteurisation of milk, which reduced the estimate to 6.4 with 95% interval (0,11. In the second

  7. Higher Education Quality Assessment in China: An Impact Study

    Science.gov (United States)

    Liu, Shuiyun

    2015-01-01

    This research analyses an external higher education quality assessment scheme in China, namely, the Quality Assessment of Undergraduate Education (QAUE) scheme. Case studies were conducted in three Chinese universities with different statuses. Analysis shows that the evaluated institutions responded to the external requirements of the QAUE…

  8. Dropout and Violence Needs Assessment: A Follow-up Study

    Science.gov (United States)

    Miltich, Aimee P.; Hunt, Mary Helen; Meyers, Joel

    2004-01-01

    The current study investigated a needs assessment survey designed to measure perceptions of causes of dropout and school violence and related interventions. The needs assessment was conceptualized as a first step to be taken by schools to facilitate program planning, school-based implementation and acceptability of programs designed to prevent…

  9. Assessment To Increase Students' Creativity: Two Case Studies.

    Science.gov (United States)

    Berglund, Anders; Daniels, Mats; Tengstrand, Anders; Hedenborg, Mathias

    1998-01-01

    Discusses the use of assessment to stimulate creativity and communication skills in engineering students. Describes full-scale studies for students in engineering, physics, computer science, and mathematics at two universities in Sweden. New examination methods include continuous assessment, seminars, mini-conferences, oral presentations, written…

  10. Three Reflections on Assessing Safety Training Needs: A Case Study

    Science.gov (United States)

    Sleezer, Catherine M.; Kelsey, Kathleen D.; Wood, Thomas E.

    2008-01-01

    Needs assessment plays an important role in training and human performance improvement efforts, but the literature contains little research on this topic. This study extended previous research on the Performance Analysis for Training (PAT) model of needs assessment by examining its implementation to determine environmental and occupational health…

  11. Unmasking Cleckley's psychopath: assessing historical case studies.

    Science.gov (United States)

    DeShong, Hilary L; Helle, Ashley C; Mullins-Sweatt, Stephanie N

    2016-05-01

    The current study investigated original case descriptions of psychopathy (Cleckley, 1941) in relation to current conceptualizations and general personality traits. Attorneys, forensic psychologists and clinical faculty members completed ratings of psychopathy and personality after reading vignettes based on Cleckley's descriptions of a psychopath. The results suggest that professionals' ratings are consistent with current conceptualizations of psychopathy. Furthermore, the five-factor model (FFM) personality traits of the vignettes aligned with the current literature on the FFM and psychopathy (i.e. low neuroticism, conscientiousness and agreeableness). The results further supported that a general trait model, like the FFM, may be well suited to describe the underlying personality traits of psychopathy. Gender differences were also examined. PMID:26931520

  12. Preliminary systems design study assessment report

    Energy Technology Data Exchange (ETDEWEB)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1991-10-01

    The System Design Study (SDS), part of the Waste Technology Development Department of the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume I contains an executive summary. The SDS summary and analysis of results are presented in Volume II. Volumes III through VII contain descriptions of twelve system and four subsystem concepts. Volume VIII contains the appendixes.

  13. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each. This volume contains the descriptions and other relevant information of the four subsystems required for most of the ex situ processing systems. This volume covers the metal decontamination and sizing subsystem, soils processing subsystem, low-level waste subsystem, and retrieval subsystem

  14. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in Volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendixes. 23 refs., 23 figs., 16 tabs

  15. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    The System Design Study (SDS), part of the Waste Technology Development Department at Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic (TRU) waste stored at the Radioactive Waste Management Complex's (RWMC's) Subsurface Disposal Area (SDA) at INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendices. 3 figs., 3 tabs

  16. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques for the remediation of hazardous and transuranic waste stored at Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume contains introduction section containing a brief SDS background and lists the general assumptions and considerations used during the development of the system concepts. The introduction section is followed by sections describing two system concepts that produce a waste form in compliance with the Waste Isolation Pilot Plant (WIPP) Waste Acceptance Criteria (WAC) and transportation package (TRAMPAC) requirements. This system concept category is referred to as Waste Form 4, ''WIPP and TRAMPAC Acceptable.'' The following two system concepts are under this category: Sort, Treat, and Repackage System (4-BE-2); Volume Reduction and Packaging System (4-BE-4)

  17. Dynamic assessment versus static assessment: A study of reading comprehension ability in Iranian EFL learners

    OpenAIRE

    Nazari, Behzad; Mansouri, Saeed

    2014-01-01

    This study extends traditional or static assessment of reading comprehension in foreign language contexts and applies dynamic assessment (DA) to the development of learners’ reading ability. To homogenize the research population (N= 250), an Oxford Placement Test (OPT) was administered. On the basis of the test results, the population was sorted into three groups of reading-low, reading-mid, and reading-high students. The participants of this study were a sample of 30 participants with the lo...

  18. Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study

    Directory of Open Access Journals (Sweden)

    Riess Hanno

    2010-03-01

    Full Text Available Abstract Background Cachexia is a common problem in patients (pts suffering from upper gastrointestinal cancer. In addition, most of these patients suffer from malabsorption and stenosis of the gastrointestinal tract due to their illness. Various methods of supplementary nutrition (enteral, parenteral are practised. In patients with advanced pancreatic cancer (APC, phase angle, determined by bio-electrical impedance analysis (BIA, seems to be a survival predictor. The positive influence of BIA determinate predictors by additional nutrition is currently under discussion. Methods To examine the impact of additional parenteral nutrition (APN we assessed outpatients suffering from APC and progressive cachexia. The assessment based on the BIA method. Assessment parameters were phase angle, ECM/BCM index (ratio of extracellular mass to body cell mass, and BMI (body mass index. Patients suffering from progressive weight loss in spite of additional enteral nutritional support were eligible for the study. Results Median treatment duration in 32 pts was 18 [8-35] weeks. Response evaluation showed a benefit in 27 pts (84% in at least one parameter. 14 pts (43.7% improved or stabilised in all three parameters. The median ECM/BCM index was 1.7 [1.11-3.14] at start of APN and improved down to 1.5 [1.12-3.36] during therapy. The median BMI increased from 19.7 [14.4-25.9] to 20.5 [15.4-25.0]. The median phase angle improved by 10% from 3.6 [2.3-5.1] to 3.9 [2.2-5.1]. Conclusions We demonstrated the positive impact of APN on the assessed parameters, first of all the phase angle, and we observed at least a temporary benefit or stabilisation of the nutritional status in the majority of the investigated patients. Based on these findings we are currently investigating the impact of APN on survival in a larger patient cohort. Trial registration ClinicalTrials.gov Identifier: NCT00919659

  19. Assessing the first wave of epidemiological studies of nanomaterial workers

    International Nuclear Information System (INIS)

    The results of early animal studies of engineered nanomaterials (ENMs) and air pollution epidemiology suggest that it is important to assess the health of ENM workers. Initial epidemiological studies of workers’ exposure to ENMs (<100 nm) are reviewed and characterized for their study designs, findings, and limitations. Of the 15 studies, 11 were cross-sectional, 4 were longitudinal (1 was both cross-sectional and longitudinal in design), and 1 was a descriptive pilot study. Generally, the studies used biologic markers as the dependent variables. All 11 cross-sectional studies showed a positive relationship between various biomarkers and ENM exposures. Three of the four longitudinal studies showed a negative relationship; the fourth showed positive findings after a 1-year follow-up. Each study considered exposure to ENMs as the independent variable. Exposure was assessed by mass concentration in 10 studies and by particle count in six studies. Six of them assessed both mass and particle concentrations. Some of the studies had limited exposure data because of inadequate exposure assessment. Generally, exposure levels were not very high in comparison to those in human inhalation chamber studies, but there were some exceptions. Most studies involved a small sample size, from 2 to 258 exposed workers. These studies represent the first wave of epidemiological studies of ENM workers. They are limited by small numbers of participants, inconsistent (and in some cases inadequate) exposure assessments, generally low exposures, and short intervals between exposure and effect. Still, these studies are a foundation for future work; they provide insight into where ENM workers are experiencing potentially adverse effects that might be related to ENM exposures

  20. Assessing the first wave of epidemiological studies of nanomaterial workers

    Energy Technology Data Exchange (ETDEWEB)

    Liou, Saou-Hsing, E-mail: shliou@nhri.org.tw [National Health Research Institutes, National Institute of Environmental Health Sciences (China); Tsai, Candace S. J. [Colorado State University, Department of Environmental and Radiological Health Science (United States); Pelclova, Daniela [Charles University in Prague, Department of Occupational Medicine, First Faculty of Medicine (Czech Republic); Schubauer-Berigan, Mary K.; Schulte, Paul A. [National Institute for Occupational Safety and Health (United States)

    2015-10-15

    The results of early animal studies of engineered nanomaterials (ENMs) and air pollution epidemiology suggest that it is important to assess the health of ENM workers. Initial epidemiological studies of workers’ exposure to ENMs (<100 nm) are reviewed and characterized for their study designs, findings, and limitations. Of the 15 studies, 11 were cross-sectional, 4 were longitudinal (1 was both cross-sectional and longitudinal in design), and 1 was a descriptive pilot study. Generally, the studies used biologic markers as the dependent variables. All 11 cross-sectional studies showed a positive relationship between various biomarkers and ENM exposures. Three of the four longitudinal studies showed a negative relationship; the fourth showed positive findings after a 1-year follow-up. Each study considered exposure to ENMs as the independent variable. Exposure was assessed by mass concentration in 10 studies and by particle count in six studies. Six of them assessed both mass and particle concentrations. Some of the studies had limited exposure data because of inadequate exposure assessment. Generally, exposure levels were not very high in comparison to those in human inhalation chamber studies, but there were some exceptions. Most studies involved a small sample size, from 2 to 258 exposed workers. These studies represent the first wave of epidemiological studies of ENM workers. They are limited by small numbers of participants, inconsistent (and in some cases inadequate) exposure assessments, generally low exposures, and short intervals between exposure and effect. Still, these studies are a foundation for future work; they provide insight into where ENM workers are experiencing potentially adverse effects that might be related to ENM exposures.

  1. Theoretical study on safety assessment indexes system of coal mines

    Institute of Scientific and Technical Information of China (English)

    SHI Shi-liang(施式亮); LI Run-qiu(李润求); XIE Jian-xiang(谢建湘)

    2003-01-01

    The safety status of the coal mines is closely correlated with the operating status and its changes of the whole working system in the coal mines, and the safety system is the sub-system of the whole production system. In this paper, based on the analysis of the complicacy of the safety sub-system and its affecting factors, the theory basis of the indexes system of the safety assessment was studied, including the establishing principles of the indexes system , the structure of the indexes system, the determining methods of the assessment indexes. The complete indexes system was established for the safety assessment of the coal mines in the paper.

  2. Exposure Assessment in the National Children’s Study: Introduction

    OpenAIRE

    Needham, Larry L.; Özkaynak, Halûk; Whyatt, Robin M.; Barr, Dana B.; Wang, Richard Y.; Naeher, Luke; Akland, Gerry; Bahadori, Tina; Bradman, Asa; Fortmann, Roy; Liu, L-J Sally; Morandi, Maria; O’Rourke, Mary Kay; Thomas, Kent; Quackenboss, James

    2005-01-01

    The science of exposure assessment is relatively new and evolving rapidly with the advancement of sophisticated methods for specific measurements at the picogram per gram level or lower in a variety of environmental and biologic matrices. Without this measurement capability, environmental health studies rely on questionnaires or other indirect means as the primary method to assess individual exposures. Although we use indirect methods, they are seldom used as stand-alone tools. Analyses of en...

  3. Deep geologic disposal. Lessons learnt from recent performance assessment studies

    International Nuclear Information System (INIS)

    Performance assessment (PA) studies are part of the decision basis for the siting, operation, and closure of deep repositories of long-lived nuclear wastes. In 1995 the NEA set up the Working Group on Integrated Performance Assessments of Deep Repositories (IPAG) with the goals to analyse existing PA studies, learn about what has been produced to date, and shed light on what could be done in future studies. Ten organisations submitted their most recent PA study for analysis and discussion, including written answers to over 70 questions. Waste management programmes, disposal concepts, geologies, and different types and amounts of waste offered a unique opportunity for exchanging information, assessing progress in PA since 1990, and identifying recent trends. A report was completed whose main lessons are overviewed. (author)

  4. Using Event Studies to Assess the Impact of Unexpected Events

    OpenAIRE

    James V Koch; Robert N Fenili

    2013-01-01

    The quantitative assessment of the financial impact of unexpected events is the realm of the “event study.” We examine how CEOs, boards, and public policymakers can utilize event studies to inform and improve their decision making. The breadth of application of event studies is surprisingly broad and ranges from situations involving the death of a CEO to emergency product recalls. We present illustrative event studies for two Steve Jobs-related announcements concerning his health in order to ...

  5. MRI based volumetric assessment of knee cartilage after ACL-reconstruction, correlated with qualitative morphologic changes in the joint and with clinical outcome. Is there evidence for early posttraumatic degeneration?

    International Nuclear Information System (INIS)

    Purpose: The purpose of this study was to analyze potential quantitative and qualitative changes of the knee cartilage and joint indicative of early posttraumatic OA 4 years after ACL-reconstruction and to correlate the MRI-findings with the clinical outcome (CO). Materials and Methods: 1.5 T MRI-scans were performed on 9 patients post-op and 4 years later. Using a high-resolution T 1-w-fs-FLASH-3D-sequence cartilage volume (cVol) and thickness (mTh) were quantified. Using standard PD-w fs and T 1-w sequences qualitative changes of the joint structures were analyzed based on the WORMS-score. CO was rated by an orthopaedic surgeon using Lysholm-score, OAK-score, Tegner-activity-score (TAS), and Arthrometer KT-1000 testing. Results: Mean changes of cVol were -1.8 % (range: -5.9 %; + 0.7 %) and of mTh -0.8 % (range: -3.0 %; + 1.1 %). No significant change (95 %-CI) could be identified for any compartment. Three patients developed new peripatellar ostheophytes, acute trauma related changes mostly decreased. Mean outcome of Lysholm-score and OAK-score were 90 pts and 86 pts, mean TAS was 4.3 pts. Average maximum tibial translation reached 5.2 mm comparing to 6.7 mm on the healthy contralateral side. Conclusion: Despite a tendency towards decreased cVol and mTh 4 years after ACL-reconstruction qMRI revealed no significant cartilage loss. Newly developing osteophytes did not match with the observed good CO. This small pilot study motivates future quantitative and qualitative-structural MRI-based assessment of articular cartilage and other joint structures in order to improve diagnostic tools for the detection of early OA. (orig.)

  6. Assessment of Confounding in Studies of Delay and Survival

    DEFF Research Database (Denmark)

    Tørring, Marie Louise; Vedsted, Peter; Frydenberg, Morten;

    influence of delay on survival have been subject to great uncertainties due to unmeasured confounding and measurement error. Systematic evaluation of confounding is needed. AIM: The purpose of this project is to assess confounding in studies of delay and survival in breast cancer patients. We aim to: 1...... based on empirical data. STUDY DESIGN 1: To identify scientific similarities and discrepancies in choice of co-variables in studies of delay and breast cancer survival we conduct a systematic review according to CRD guidelines with special focus on statistical model building. Our study is based on a...... previous work by Richards et al.: Influence of delay on survival in patients with breast cancer: a systematic review (Lancet 1999;353:1119-26). STUDY DESIGN 2: To assess the importance of potential confounders and intermediate variables in observational studies of delay and survival we test commonly used...

  7. Assessment

    Institute of Scientific and Technical Information of China (English)

    Geoff Brindley

    2005-01-01

    @@ Introduction TERMINOLOGY AND KEY CONCEPTS The term assessment refers to a variety of ways of collecting information on a learner's language ability or achievement. Although testing and assessment are often used interchangeably, the latter is an umbrella term encompassing measurement instruments administered on a ‘one-off’ basis such as tests, as well as qualitative methods of monitoring and recording student learning such as observation, simulations of project work. Assessment is also distinguished from evaluation which is concerned with the overall language programme and not just with what individual students have learnt. Proficiency assessment refers to the assessment of general language abilities acquired by the learner independent of a course of study.This kind of assessment is often done through the administration of standardised commercial language-proficency tests. On the other hand, assessment of achievement aims to establish what a student had learned in relation to a particular course or curriculum (thus frequently carried out by the teacher) .Achievement assesssment may be based either on the specific content of the course or on the course objectives (Hughes 1989).

  8. Context Sampling Descriptive Assessment: A Pilot Study of a Further Approach to Functional Assessment

    Science.gov (United States)

    Garbutt, Nathalie; Furniss, Frederick

    2007-01-01

    Background: The ability of descriptive assessments to differentiate functions of problem behaviours might be increased by systematically sampling natural contexts characterized by different establishing operations. This study evaluated the stability of such characteristics, and variability in challenging behaviour, for three school contexts.…

  9. Assessing Middle and High School Social Studies & English: Differentiating Formative Assessment

    Science.gov (United States)

    Waterman, Sheryn Spencer

    2010-01-01

    For middle and high school teachers of social studies and English, this book is filled with examples of instructional strategies that address students' readiness levels, interests, and learning preferences. It shows teachers how to formatively assess their students by addressing differentiated learning targets. Included are detailed examples of…

  10. [Social support assessment in Brazilian studies: conceptual aspects and measures].

    Science.gov (United States)

    Gonçalves, Tonantzin Ribeiro; Pawlowski, Josiane; Bandeira, Denise Ruschel; Piccinini, Cesar Augusto

    2011-03-01

    This study investigated the different ways of evaluating the social support in Brazilian studies. A surveying of scientific Brazilian publications from 1987 to 2007 was done in the Indexpsi, Pepsic, SciELO and Lilacs databases according to keywords social support and social network. Fifty-five studies included some type of assessing social support in Brazilian samples. The results indicated a rise in the number of studies about social support assessment in the last years using interviews to investigate received and perceived support, predominantly. However, the construction was applied without theoretical basis and was associated with many other concepts, sometimes without an appropriate articulation. Besides, there were evidences of lacking reliable, valid and standardized instruments to Brazilian population by considering the instruments currently used and revised by this study. PMID:21519666

  11. Assessing Meritorious Teacher Performance: A Differential Validity Study.

    Science.gov (United States)

    Ellett, Chad D; Capie, William

    The Teacher Assessment and Development System (TADS) - Meritorious Teacher Program (MTP) FORM instrument is used in the Dade County Public Schools, Miami, Florida, to evaluate teachers. Its validity for decisions concerning merit pay for master teachers was examined in this study. Specifically, its ability to discriminate between high performing…

  12. Assessing Student Learning in the Major Field of Study

    Science.gov (United States)

    Volkwein, J. Fredericks

    2010-01-01

    Assessing student attainment in the major field of study is increasingly important to employers and accrediting bodies alike. Construction and manufacturing firms do not like engineers who design faulty bridges and airplanes. Marketing firms want to hire students who understand the difference between a niche market and a global market. School…

  13. Assessing the Flipped Classroom in Operations Management: A Pilot Study

    Science.gov (United States)

    Prashar, Anupama

    2015-01-01

    The author delved into the results of a flipped classroom pilot conducted for an operations management course module. It assessed students' perception of a flipped learning environment after making them experience it in real time. The classroom environment was construed using a case research approach and students' perceptions were studied using…

  14. Exposure assessment in studies on health effects of traffic exhaust

    Energy Technology Data Exchange (ETDEWEB)

    Setaelae, S. [Association for the Pulmonary Disabled, Helsinki (Finland); Jaakkola, J.J.K. [Helsinki Univ. (Finland). Dept. of Public Health

    1995-12-31

    A main source of outdoor air pollution is road traffic, which produces a complex mixture of nitrogen oxides, carbon monoxide, volatile hydrocarbons, airborne particles and some other compounds. Traffic exhaust affects also the concentrations of ozone and other photo chemical oxidants. In earlier studies those components have had remarkable health effects. Several studies on occupational exposure to automobile exhaust have been published and several studies have been observed an association between both outdoor and indoor pollutant levels and health outcomes. However, there are only a few epidemiological studies in which traffic exhaust, a complex mixture, has been studied in its entirety. During recent years, interesting epidemiological studies of the health effects of this complex mixture have been published. Human exposure assessment for traffic exhaust can be categorized according to the environment of exposure (indoors, outdoors, in-traffic) or to the method of exposure assessment (direct or indirect methods). In this presentation the methods are further categorized into (1) traffic activity, (2) air concentration measurements, and (3) dispersion models, in order to better understand the advantages and disadvantages of different approaches. The objective of this presentation is to make a critical review of exposure assessments in the epidemiological studies on health effects of traffic exhaust. (author)

  15. Development Impact Assessment (DIA) Case Study. South Africa

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Sadie [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Nawaz, Kathleen [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Sandor, Debra [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2015-05-19

    This case study reviews South Africa’s experience in considering the impacts of climate change action on development goals, focusing on the South African energy sector and development impact assessments (DIAs) that have and could be used to influence energy policy or inform the selection of energy activities. It includes a review of assessments—conducted by government ministries, technical partners, and academic institutes and non-governmental organizations (NGOs)—that consider employment, health, and water implications of possible energy sector actions, as well as multi-criteria impact assessments.

  16. A human factors needs assessment and planning study

    International Nuclear Information System (INIS)

    A study was done to assess the need for human factors research, development, and regulatory action in the Atomic Energy Control Board. Further study or development in nine human factors areas is proposed. The urgency, schedule, and resources judged to be necessary for the proposed efforts are estimated. Special emphasis is placed on the need for task analysis information, for the evaluation of control room and maintenance human engineering, and for the development of an improved human error reporting system

  17. Agricultural soils potentially contaminated: risk assessment procedure case studies

    Directory of Open Access Journals (Sweden)

    Eleonora Beccaloni

    2010-01-01

    Full Text Available At the moment, the health-environmental risk analysis is used to decision-making targets in the contaminated sites management; this procedure allows to assess the quantitative health risk related to the pollutants presence in environmental compartments, as soil and waters. As regards potentially contaminated agricultural soils, the ingestion of food from vegetable and/or animal source, produced inside the contaminated area, is the most suitable way to assess the health risk. As an official procedure to this assessment is not available, the National Institute for Health (Istituto Superiore di Sanità, ISS has worked out an operating procedure, organized into several phases, depending on the available specific-site know-how. In this document, agricultural soils potentially contaminated in two sites have been studied; the sites are the following: Brescia Caffaro and Torviscosa.

  18. Report of the Study Group on Assessment and Evaluation

    CERN Document Server

    Crouch, R; Netter, K; Crouch, Richard; Gaizuaskas, Robert; Netter, Klaus

    1996-01-01

    This is an interim report discussing possible guidelines for the assessment and evaluation of projects developing speech and language systems. It was prepared at the request of the European Commission DG XIII by an ad hoc study group, and is now being made available in the form in which it was submitted to the Commission. However, the report is not an official European Commission document, and does not reflect European Commission policy, official or otherwise. After a discussion of terminology, the report focusses on combining user-centred and technology-centred assessment, and on how meaningful comparisons can be made of a variety of systems performing different tasks for different domains. The report outlines the kind of infra-structure that might be required to support comparative assessment and evaluation of heterogenous projects, and also the results of a questionnaire concerning different approaches to evaluation.

  19. Approaches to Children's Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP).

    Science.gov (United States)

    Ginsberg, Gary; Ginsberg, Justine; Foos, Brenda

    2016-01-01

    Children's exposure assessment is a key input into epidemiology studies, risk assessment and source apportionment. The goals of this article are to describe a methodology for children's exposure assessment that can be used for these purposes and to apply the methodology to source apportionment for the case study chemical, diethylhexylphthalate (DEHP). A key feature is the comparison of total (aggregate) exposure calculated via a pathways approach to that derived from a biomonitoring approach. The 4-step methodology and its results for DEHP are: (1) Prioritization of life stages and exposure pathways, with pregnancy, breast-fed infants, and toddlers the focus of the case study and pathways selected that are relevant to these groups; (2) Estimation of pathway-specific exposures by life stage wherein diet was found to be the largest contributor for pregnant women, breast milk and mouthing behavior for the nursing infant and diet, house dust, and mouthing for toddlers; (3) Comparison of aggregate exposure by pathways vs biomonitoring-based approaches wherein good concordance was found for toddlers and pregnant women providing confidence in the exposure assessment; (4) Source apportionment in which DEHP presence in foods, children's products, consumer products and the built environment are discussed with respect to early life mouthing, house dust and dietary exposure. A potential fifth step of the method involves the calculation of exposure doses for risk assessment which is described but outside the scope for the current case study. In summary, the methodology has been used to synthesize the available information to identify key sources of early life exposure to DEHP. PMID:27376320

  20. Preliminary Study on Conducting Experiments for Assessment of Secondary Stresses

    International Nuclear Information System (INIS)

    In order to validate the new procedure for assessment of cracks in ductile materials with presence of high secondary stresses, access to the experimental results is needed. Such experimental results are very limited in the published literature. In this report, different test options are studied in order to find a proper test program to study the effects of secondary stresses at high levels of primary stresses. These options consider the use of thermal transients or welding residual stresses in the test program. A total of 36 different cases considering crack configuration, type of thermal transient and the level of mechanical loading are studied here. The fracture assessments of these cases are conducted based on the R6-method. Based on the assessment results conducted in this study, the following options are proposed for conducting the test program: Option 1: To use a thermal transient with T0 = 200 deg C and h = 5 kW/m2 deg C on edge surface cracked plates with a/t = 0.3 subjected to a mechanical bending of σb/σY > 0.8. Option 2: To use welding residual stresses on edge surface cracked plates with a/t 0.3 subjected to a mechanical bending of σb/σY > 0.6. Option 3: To use mechanically induced residual stresses (in-plane compression) in edge surface cracked specimens subjected to a mechanical bending

  1. Preschool Self-Regulation Assessment (PSRA): Adaptation Study for Turkey

    OpenAIRE

    Fındık Tanrıbuyurdu, Ezgi; Ankara Üniversitesi, Sağlık Bilimleri Fakültesi, Çocuk Gelişimi Bölümü; Güler Yıldız, Tülin; Hacettepe Üniversitesi, Eğitim Fakültesi, İlköğretim Bölümü, Okul Öncesi Eğitimi AD

    2014-01-01

    The aim of this study is to conduct the validity and reliability studies of the Preschool Self-Regulation Assessment (PSRA) in Turkey. The study was carried out with 233 children, aging between 48-72 months. First of all, the scale was translated from the source language, and then translated back to the source language by experts and the texts were checked for consistency. The tasks in the scale were then reviewed by domain experts. Scoring was conducted simultaneously by the researcher and a...

  2. A kind of the PAPR of OFDM system using improved PTS method%一种OFDM系统峰均比的改良PTS算法

    Institute of Scientific and Technical Information of China (English)

    李欣; 胡晓天; 管绍军; 孙继明

    2012-01-01

    Partial Transmit Sequence (PTS) method by choosing the appropriate phase sequence to reduce the probability of the Signal peak, this method does not make the signal distortion. But conventional PTS technique is very large computational complexity, needing to traverse all the optional phase factor, its calculation sequence as the number of separate exponential growth. In this paper, proposing a multi-phase sequence is inverted binary tree method, this method by symmetrical tree searching, searching out the optimal phase sequence. Simulating results show that the method reduces the system complexity, while better suppress the PAPR.%部分传输序列(PTS)方法通过选择合适的相位序列以降低信号峰值出现的概率,该方法不会使信号发生畸变。但是传统的PTS技术计算复杂度非常大,需遍历所有可选的相位因子,其计算量随分割子序列数按指数增长。本文提出了一种正倒二叉树多层相位序列方法,该方法通过对称的树形搜索,搜索出最优的相位序列。仿真结果表明,该方法大大降低系统的复杂度.同时PAPR得到更好地抑制。

  3. RpoS synthesis is growth rate regulated in Salmonella typhimurium, but its turnover is not dependent on acetyl phosphate synthesis or PTS function.

    Science.gov (United States)

    Cunning, C; Elliott, T

    1999-08-01

    The RpoS sigma factor of enteric bacteria is either required for or augments the expression of a number of genes that are induced during nutrient limitation, growth into stationary phase, or in response to stresses, including high osmolarity. RpoS is regulated at multiple levels, including posttranscriptional control of its synthesis, protein turnover, and mechanisms that affect its activity directly. Here, the control of RpoS stability was investigated in Salmonella typhimurium by the isolation of a number of mutants specifically defective in RpoS turnover. These included 20 mutants defective in mviA, the ortholog of Escherichia coli rssB/sprE, and 13 mutants defective in either clpP or clpX which encode the protease active on RpoS. An hns mutant was also defective in RpoS turnover, thus confirming that S. typhimurium and E. coli have identical genetic requirements for this process. Some current models predict the existence of a kinase to phosphorylate the response regulator MviA, but no mutants affecting a kinase were recovered. An mviA mutant carrying the D58N substitution altering the predicted phosphorylation site is substantially defective, suggesting that phosphorylation of MviA on D58 is important for its function. No evidence was obtained to support models in which acetyl phosphate or the PTS system contributes to MviA phosphorylation. However, we did find a significant (fivefold) elevation of RpoS during exponential growth on acetate as the carbon and energy source. This behavior is due to growth rate-dependent regulation which increases RpoS synthesis at slower growth rates. Growth rate regulation operates at the level of RpoS synthesis and is mainly posttranscriptional but, surprisingly, is independent of hfq function. PMID:10438755

  4. A study on safety assessment methodology for a vitrification plant

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Y. C.; Lee, G. S.; Choi, Y. C.; Kim, G. H. [Yonsei Univ., Seoul (Korea, Republic of)

    2002-03-15

    In this study, the technical and regulatory status of radioactive waste vitrification technologies in foreign and domestic plants is investigated and analyzed, and then significant factors are suggested which must be contained in the final technical guideline or standard for the safety assessment of vitrification plants. Also, the methods to estimate the stability of vitrified waste forms are suggested with property analysis of them. The contents and scope of the study are summarized as follows : survey of the status on radioactive waste vitrification technologies in foreign and domestic plants, survey of the characterization methodology for radioactive waste form, analysis of stability for vitrified waste forms, survey and analysis of technical standards and regulations concerned with them in foreign and domestic plants, suggestion of significant factors for the safety assessment of vitrification plants, submission of regulated technical standard on radioactive waste vitrification plats.

  5. MRI based volumetric assessment of knee cartilage after ACL-reconstruction, correlated with qualitative morphologic changes in the joint and with clinical outcome. Is there evidence for early posttraumatic degeneration?; MRT-basierte Knorpelvolumetrie nach Kreuzbandersatzplastik in Korrelation mit qualitativen Gelenkveraenderungen und dem klinischen Outcome. Gibt es Hinweise auf fruehzeitige posttraumatische degenerative Veraenderungen?

    Energy Technology Data Exchange (ETDEWEB)

    Arnoldi, A.P.; Weckbach, S.; Horng, A.; Reiser, M. [Ludwig-Maximilians-Univ. Muenchen (Germany). Dept. of Clinical Radiology; Nussbickel, C. [Klinikum Garmisch-Partenkirchen (Germany). Dept. of Internal Medicine; Noebauer, I. [Medizinische Universitaet Wien (Austria). Klinik fuer Radiodiagnostik; Zysk, S. [Orthopaedie Zentrum Groebenzell (Germany). Center of Orthopaedics; Glaser, C. [NYU Medical Center, New York, NY (United States). Dept. of Radiology

    2011-12-15

    Purpose: The purpose of this study was to analyze potential quantitative and qualitative changes of the knee cartilage and joint indicative of early posttraumatic OA 4 years after ACL-reconstruction and to correlate the MRI-findings with the clinical outcome (CO). Materials and Methods: 1.5 T MRI-scans were performed on 9 patients post-op and 4 years later. Using a high-resolution T 1-w-fs-FLASH-3D-sequence cartilage volume (cVol) and thickness (mTh) were quantified. Using standard PD-w fs and T 1-w sequences qualitative changes of the joint structures were analyzed based on the WORMS-score. CO was rated by an orthopaedic surgeon using Lysholm-score, OAK-score, Tegner-activity-score (TAS), and Arthrometer KT-1000 testing. Results: Mean changes of cVol were -1.8 % (range: -5.9 %; + 0.7 %) and of mTh -0.8 % (range: -3.0 %; + 1.1 %). No significant change (95 %-CI) could be identified for any compartment. Three patients developed new peripatellar ostheophytes, acute trauma related changes mostly decreased. Mean outcome of Lysholm-score and OAK-score were 90 pts and 86 pts, mean TAS was 4.3 pts. Average maximum tibial translation reached 5.2 mm comparing to 6.7 mm on the healthy contralateral side. Conclusion: Despite a tendency towards decreased cVol and mTh 4 years after ACL-reconstruction qMRI revealed no significant cartilage loss. Newly developing osteophytes did not match with the observed good CO. This small pilot study motivates future quantitative and qualitative-structural MRI-based assessment of articular cartilage and other joint structures in order to improve diagnostic tools for the detection of early OA. (orig.)

  6. Reliability of Pubertal Self Assessment Method: An Iranian Study

    OpenAIRE

    Ali Rabbani; Shahab Noorian; Fallah, Javad S.; Arya Setoudeh; Fatemeh Sayarifard; Farzaneh Abbasi

    2013-01-01

    Objective: This investigation aims to evaluate the validity of a Persian Tanner Stages Self-Assessment QuestionnaireMethods: In this cross sectional study, 190 male students aged 8-16 years selected from three layers of different regions of Tehran (North, Central and South) were enrolled. A Persian questionnaire illustrated with Tanner stages of puberty (genital development and pubic hair distribution) was prepared. Children were asked to select the illustration that best described their pube...

  7. Instruments for the assessment of social anxiety disorder: Validation studies

    OpenAIRE

    Osório, Flávia de Lima; Crippa, José Alexandre de Souza; Loureiro, Sonia Regina

    2012-01-01

    Great progress has been observed in the literature over the last decade regarding the validation of instruments for the assessment of Social Anxiety Disorder in the Brazilian context. Particularly outstanding in this respect is the production of a group of Brazilian investigators regarding the psychometric study of the following instruments: Liebowitz Social Anxiety Scale, Social Phobia Inventory, Brief Social Phobia Scale, Disability Profile, Liebowitz Self-Rated Disability Scale, Social Pho...

  8. Studies on partially polymerized 2,4-hexadiyn-1,6-bis(p-toluenesulfonate)

    International Nuclear Information System (INIS)

    An improved procedure for the synthesis of high-purity 2,4-hexadiyn-1,6-bis(p-toluenesulfonate) (PTS) is described. The melting point of partially polymerized PTS increases monotonically with increasing polymer conversion (<12%). The increase in melting point is due to formation of a solid solution of unreacted monomer and polymer chains. The relation between the melting point and polymer conversion can be used for determination of polymer conversion. The low-conversion (<12%) polyPTS is soluble in dimethylformamide. The solution is yellow (lambda/sub max/ approx. = 450 nm) and does not undergo a color change when the temperature is lowered or a nonsolvent is added. Gel permeation chromatography (GPC) studies show that the molecular weight distribution of polyPTS is very broad and does not change with increasing polymer conversion up to <12%. The degree of polymerization for the low-conversion polyPTS is very low, about 20 repeat units. The G value for initiation centers (radicals) is about 2. The properties of the low-conversion partially polymerized PTS are compared with the corresponding properties of poly

  9. Assessment of apical periodontitis by MRI. A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Geibel, M.A. [Ulm Univ. (Germany). Oral and Maxillofacial Surgery; Schreiber, E.S.; Bracher, A.K.; Rasche, V. [Ulm Univ. (Germany). Internal Medicine II; Hell, E.; Ulrici, J. [Sirona Dental Systems GmbH, Bensheim (Germany). Dental Imaging; Sailer, L.K. [DOC Praxisklinik im Wiley, Neu-Ulm (Germany). MKG; Ozpeynirci, Y. [Ulm Univ. (Germany). Diagnostic and Interventional Radiology

    2015-04-15

    The purpose of this clinical feasibility study was to evaluate the applicability of magnetic resonance imaging (MRI) for the assessment of apical periodontitis in direct comparison with cone beam CT (CBCT). 19 consecutive patients (average age 43 ± 13 years) with 34 lesions in total (13 molars, 14 premolars and 7 front teeth) were enrolled in this feasibility study. Periapical lesions were defined as periapical radiolucencies (CBCT) or structural changes in the spongy bone signal (MRI), which were connected with the apical part of a root and with at least twice the width of the periodontal ligament space. The location and dimension of the lesions were compared between MRI and CBCT. While mainly mineralized tissue components such as teeth and bone were visible with CBCT, complimentary information of the soft tissue components was assessable with MRI. The MRI images provided sufficient diagnostic detail for the assessment of the main structures of interest. Heterogeneous contrast was observed within the lesion, with often a clear enhancement close to the apical foramen and the periodontal gap. No difference for lesion visibility was observed between MRI and CBCT. The lesion dimensions corresponded well, but were slightly but significantly overestimated with MRI. A heterogeneous lesion appearance was observed in several patients. Four patients presented with a well circumscribed hyperintense signal in the vicinity of the apical foramen. The MRI capability of soft tissue characterization may facilitate detailed analysis of periapical lesions. This clinical study confirms the applicability of multi-contrast MRI for the identification of periapical lesions.

  10. Development of a Burn Escharotomy Assessment Tool: A Pilot Study.

    Science.gov (United States)

    Ur, Rebecca; Holmes, James H; Johnson, James E; Molnar, Joseph A; Carter, Jeffrey E

    2016-01-01

    Severe burn injuries can require escharotomies which are urgent, infrequent, and relatively high-risk procedures necessary to preserve limb perfusion and sometimes ventilation. The American Burn Association Advanced Burn Life Support© course educates surgeons and emergency providers about escharotomy incisions but lacks a biomimetic trainer to demonstrate, practice, or provide assessment. The goal was to build an affordable biomimetic trainer with discrete points of failure and pilot a validation study. Fellowship-trained burn and plastic surgeons worked with special effect artists and anatomists to develop a biomimetic trainer with three discrete points of failure: median or ulnar nerve injury, fasciotomy, and failure to check distal pulse. Participants were divided between experienced and inexperienced, survey pre- and post-procedure on a biomimetic model while being timed. The trainer total cost per participant was less than $35. Eighteen participants were involved in the study. The inexperienced (0-1 prior escharotomies performed) had significantly more violations at the discrete points of failure relative to more experienced participants (P = .036). Face validity was assessed with 100% of participants agreement that the model appeared similar to real life and was valuable in their training. Given the advancements in biomimetic models and the need to train surgeons in how to perform infrequent, emergent surgical procedures, an escharotomy trainer is needed today. The authors developed an affordable model with a successful pilot study demonstrating discrimination between experienced and inexperienced surgeons. Additional research is needed to increase the reliability and assessment metrics. PMID:26594860

  11. Assessment of apical periodontitis by MRI. A feasibility study

    International Nuclear Information System (INIS)

    The purpose of this clinical feasibility study was to evaluate the applicability of magnetic resonance imaging (MRI) for the assessment of apical periodontitis in direct comparison with cone beam CT (CBCT). 19 consecutive patients (average age 43 ± 13 years) with 34 lesions in total (13 molars, 14 premolars and 7 front teeth) were enrolled in this feasibility study. Periapical lesions were defined as periapical radiolucencies (CBCT) or structural changes in the spongy bone signal (MRI), which were connected with the apical part of a root and with at least twice the width of the periodontal ligament space. The location and dimension of the lesions were compared between MRI and CBCT. While mainly mineralized tissue components such as teeth and bone were visible with CBCT, complimentary information of the soft tissue components was assessable with MRI. The MRI images provided sufficient diagnostic detail for the assessment of the main structures of interest. Heterogeneous contrast was observed within the lesion, with often a clear enhancement close to the apical foramen and the periodontal gap. No difference for lesion visibility was observed between MRI and CBCT. The lesion dimensions corresponded well, but were slightly but significantly overestimated with MRI. A heterogeneous lesion appearance was observed in several patients. Four patients presented with a well circumscribed hyperintense signal in the vicinity of the apical foramen. The MRI capability of soft tissue characterization may facilitate detailed analysis of periapical lesions. This clinical study confirms the applicability of multi-contrast MRI for the identification of periapical lesions.

  12. Juvenile idiopathic arthritis outcome and prognosis according to catamnesis evaluation

    Directory of Open Access Journals (Sweden)

    O V Semenova

    2005-01-01

    Full Text Available Objective. To study outcome and prognosis in pts with juvenile idiopathic arthritis (JIA. Material and methods. 239 JIA pts with disease duration of 10 years and more were analyzed. 80 children and adolescents before 18 years old (66 girls and 14 boys were included in group 1. Arthritis clinical and laboratory activity, radiological stage and functional status according to Steinbroker and CHAQ questionnaire were assessed. 159 grown up pts (109 female and 50 male suffering from JIA from childhood were included in group 2. They were examined using Stanford Health Assessment Questionnaire (HAQ and a specially developed social status questionnaire. Results. Half pts of group 1 had recurrence of the disease during examination but activity in most cases did not exceed stage I or 2 (54% and 31% respectively. Joint destructive changes were revealed in 50% of pts. 80% of pts had radiological signs of secondary osteoarthritis. Amyloidosis was revealed in 2 from 27 pts with systemic type of JIA. 68% of pts had 1 or 2 functional class. 1/3 of pts did not have functional limitations (CHAQ=0. 13% of pts had maximal disability with CHAQ ranging from 2,1 to 3,0 (pts with polyarticular and systemic types of JIA. Most grown up pts (59% considered their health as good. Substantial part of them worked or learned. 10 pts did not worked because of the disease (1,5%. 61% of pts did not have functional limitations (HAQ=0. 32% of pts were disabled. Most of them had 3 or 2 disability degree and had possibility to work. Conclusion. Substantial part of pts with longstanding JIA have stabilization of the disease or remission. Recurrent course of the disease was characterized by decrease of activity. Most children and grown ups with longstanding disease have relatively benign functional outcome. Pts with polyarticular and systemic types of JIA require especial attention because they have maximal risk of joint destruction with severe disability.

  13. Development of a Probabilistic Assessment Methodology for Evaluation of Carbon Dioxide Storage

    Science.gov (United States)

    Burruss, Robert A.; Brennan, Sean T.; Freeman, P.A.; Merrill, Matthew D.; Ruppert, Leslie F.; Becker, Mark F.; Herkelrath, William N.; Kharaka, Yousif K.; Neuzil, Christopher E.; Swanson, Sharon M.; Cook, Troy A.; Klett, Timothy R.; Nelson, Philip H.; Schenk, Christopher J.

    2009-01-01

    This report describes a probabilistic assessment methodology developed by the U.S. Geological Survey (USGS) for evaluation of the resource potential for storage of carbon dioxide (CO2) in the subsurface of the United States as authorized by the Energy Independence and Security Act (Public Law 110-140, 2007). The methodology is based on USGS assessment methodologies for oil and gas resources created and refined over the last 30 years. The resource that is evaluated is the volume of pore space in the subsurface in the depth range of 3,000 to 13,000 feet that can be described within a geologically defined storage assessment unit consisting of a storage formation and an enclosing seal formation. Storage assessment units are divided into physical traps (PTs), which in most cases are oil and gas reservoirs, and the surrounding saline formation (SF), which encompasses the remainder of the storage formation. The storage resource is determined separately for these two types of storage. Monte Carlo simulation methods are used to calculate a distribution of the potential storage size for individual PTs and the SF. To estimate the aggregate storage resource of all PTs, a second Monte Carlo simulation step is used to sample the size and number of PTs. The probability of successful storage for individual PTs or the entire SF, defined in this methodology by the likelihood that the amount of CO2 stored will be greater than a prescribed minimum, is based on an estimate of the probability of containment using present-day geologic knowledge. The report concludes with a brief discussion of needed research data that could be used to refine assessment methodologies for CO2 sequestration.

  14. HERMES docking/berthing system pilot study. Quantitative assessment

    International Nuclear Information System (INIS)

    This study falls within the framework of the incorporation of quantitative risk assessment to the activities planned for the ESA-HERMES project (ESA/ CNES). The main objective behind the study was the analysis and evaluation of the potential contribution of so-called probabilistic or quantitative safety analysis to the optimization of the safety development process for the systems carrying out the safety functions required by the new and complex HERMES Space Vehicle. For this purpose, a pilot study was considered a good start in quantitative safety assessments (QSA), as this approach has been frequently used in the past to establish a solid base in large-scale QSA application programs while avoiding considerable economic risks. It was finally decided to select the HERMES docking/berthing system with Man Tender Free Flyer as the case-study. This report describes the different steps followed in the study, along with the main insights obtained and the general conclusions drawn from the study results. (author)

  15. Technetium-99m Sestamibi and [F18]Fluorodeoxyglucose (FDG) PET in assessing patients with multiple myeloma

    International Nuclear Information System (INIS)

    Full text: The aim of the study is to evaluate the diagnostic and prognostic value of 99mTc-Sestamibi (MIBI) in the detection on bone marrow involvement in patients suffering from Multiple Myeloma (MM), its possible role in the follow-up and comparison of 99mTc-MIBI and [F18]FDG PET imaging. We present the results, for patients at our institution, that have undergone 99mTc-MIBI scans to assess MM. We considered patients (pts) with MM (in active disease, partial and chronic remission) and with monoclonal gammopathy of undetermined significance (MGUS). A subgroup of patients with MM repeated a 99mTc-MIBI scintigraphic study at least 2 months after high-dose chemotherapy. All the scans were scored semi-quantitatively according to extension and intensity of tracer uptake. Twelve patients had concurrent 99mTc-MIBI and [F18]FDG PET. The overall sensitivity of the 99mTc-MIBI scintigraphy was 92%, specificity was 96%. In the follow up of the pts treated with chemotherapy 99mTc-sestamibi closely paralleled the activity of myeloma bone disease. A multivariate analysis showed that 99mTc-MIBI uptake pattern has an added value in relation to known prognostic variables. In another study, patients showing disease progression at restaging had higher washout of 99mTc-MIBI (10 and 60 minutes) than patients in remission; disease free survival was significantly better in patients with lower washout in absence of differences in therapeutic regimen and stage of disease at admission. [F18]FDG-PET and MIBI were concordant in seven of 12 cases (58%); only in one case FDG detected bone marrow sites in addition to those detected by 99mTc-MIBI. Our experience indicates that 99mTc-MIBI scintigraphy closely reflects myeloma disease activity in the bone marrow, and that a negative 99mTc-MIBI scan in pts with suspected MM indicates absence of disease or clinical remission. The results of these studies suggest a potential role of 99mTc-MIBI washout in predicting response to chemotherapy in

  16. Treatment of operator actions in the HTGR risk assessment study

    International Nuclear Information System (INIS)

    Methods are presented for the treatment of operator actions, developed in the AIPA risk assessment study. Some examples are given of how these methods were applied to the analysis of potential HTGR accidents. Realistic predictions of accident risks required a balanced treatment of both beneficial and detrimental actions and responses of human operators and maintenance crews. Th essential elements of the human factors methodology used in the AIPA study include event tree and fault tree analysis, time-dependent operator response and repair models, a method for quantifying common cause failure probabilities, and synthesis of relevant experience data for use in these models

  17. Offshore risk assessment principles, modelling and applications of QRA studies

    CERN Document Server

    Vinnem, Jan-Erik

    2007-01-01

    attempt has been made to capture the new trends in the regulations, to the extent they are known. There have over the last 10-15 years been published a few textbooks on risk assessment, most of them are devoted to relatively generic topics. Some are also focused on the risk management aspects, in general and with offshore applicability. None are known to address the needs and topics of the use of QRA studies by the offshore industry in particular. The present work is trying to bridge this gap. The use of QRA studies is somewhat special in Northern Europe, and par- cularly in Norway. The use of

  18. Proposed motor development assessment protocol for epidemiological studies in children.

    Science.gov (United States)

    Rosenbaum, P L; Missiuna, C; Echeverria, D; Knox, S S

    2009-01-01

    This paper proposes an approach to the implementation of a large-scale epidemiological study of child development. It addresses specifically how one might assess gross motor development longitudinally in a large population-based study of children, and recommends a three-phase process. Phase I, applied at key ages with the entire population, involves the use of parent-report screening tools that ask about specific age-appropriate motor skills, as well as any parental concerns about "quantity" or "quality" of their child's motor function and about any loss of motor function. In phase II, children who "fail" the screening phase (at any stage) are evaluated with specified developmental motor assessments. Those who "pass" revert to the screening stream, while those who "fail" continue to phase III. In this third component of the study, children are referred to experts in child development formally engaged in the study (including developmental paediatricians, paediatric neurologists and developmental therapists). These experts will use protocol-based evaluations to ascertain whether a child has a problem in development, what the problem might be from a diagnostic perspective, how "severe" the problem is, and what management services are or should be provided. It is argued that this is an efficient approach to the study of a population that would enable investigators to detect specific relatively common developmental motor disorders (in particular, cerebral palsy and developmental coordination disorder). PMID:19098137

  19. Market assessment and technical feasibility study of PFBC ash use

    Energy Technology Data Exchange (ETDEWEB)

    Smith, V.E.; Bland, A.E.; Brown, T.H. [Western Research Inst., Laramie, WY (United States); Georgiou, D.N. [Jacques, Whitford and Associates Ltd., Dartmouth, NS (Canada); Wheeldon, J. [Electric Power Research Inst., Palo Alto, CA (United States)

    1994-10-01

    The overall objectives of this study are to determine the market potential and the technical feasibility of using PFBC ash in high volume ash use applications. The information will be of direct use to the utility industry in assessing the economics of PFBC power generation in light of ash disposal avoidance through ash marketing. In addition, the research is expected to result in the generation of generic data on the use of PFBC ash that could lead to novel processing options and procedures. The specific objectives of the proposed research and demonstration effort are: Define resent and future market potential of PFBC ash for a range of applications (Phase I); assess the technical feasibility of PFBC ash use in construction, civil engineering and agricultural applications (Phase II); and demonstrate the most promising of the market and ash use options in full-scale field demonstrations (Phase III).

  20. Wuskwatim generation project : Canadian Environmental Assessment Act comprehensive study report

    International Nuclear Information System (INIS)

    This study report described the plan by Manitoba Hydro and the Nisichawayasihk Cree Nation (NCN) to construct a new 200- megawatt (MW) generating station at Taskinigup Falls on the Burntwood River, near the outlet of Wuskwatim Lake. This hydroelectric power project will allow Manitoba Hydro to meet its projected energy needs within the next two decades as identified in its 2002/03 Power Resource Plan. It will also allow Manitoba Hydro and NCN to obtain additional export revenues and profits by advancing the in-service date of the Project from 2020 to 2009. A formal environmental assessment is required under the Canadian Environmental Assessment Act (CEAA) because Fisheries and Oceans Canada (DFO) has determined that the Project would cause fish habitat losses requiring an authorization under the Fisheries Act. Many of the structures to be built in navigable waters would also require formal approval under the Navigable Waters Protection Act (NWPA), which has prompted this application of the CEAA. This environmental assessment report has been prepared by DFO in consultation with Transport Canada and other federal authorities concerned. It provides a summary of the Wuskwatim Generation Project and the environment in which it will be built and operated. In addition, the results of public consultations are discussed. It presents an assessment of the Project's influence on fish and fish habitat, birds, species at risk, human health (local air quality, quality of drinking water and consumption of fishery products), navigation, use of renewable resources, and current use of lands and resources for traditional purposes by Aboriginal persons (hunting, trapping, gathering, subsistence fishing and heritage sites). It was concluded that the proposed Project, as defined by the scope of the study, is not likely to cause significant adverse environmental effects. 45 refs., 5 tabs., 13 figs., 3 appendices

  1. Do formative assessments promote self assessment accuracy? A study of second year medical students’ predictions about performance

    OpenAIRE

    Relan, Anju; Guiton, Gretchen; Sopher, Michael; Goldhaber, Josh

    2006-01-01

    Self assessment accuracy is an essential precursor to the development of self-directed learning- a desired goal of medical education. The purpose of this study was to determine medical students’ long term accuracy of performance prediction, evaluated in the context of formative assessments designed to provide practice for the summative assessment. Students were asked to predict their performance on the final exam over six formative assessments and at the end of the final exam. Students’ co...

  2. Final Technical Report: Renewable Energy Feasibility Study and Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Mariah [BEC Environmental, Inc., Las Vegas, NV (United States)

    2016-02-28

    In March 2011, the U.S. Department of Energy (DOE) awarded White Pine County, Nevada, a grant to assess the feasibility of renewable resource-related economic development activities in the area. The grant project included a public outreach and training component and was to include a demonstration project; however, the demonstration project was not completed due to lack of identification of an entity willing to locate a project in White Pine County. White Pine County completed the assessment of renewable resources and a feasibility study on the potential for a renewable energy-focused economic sector within the County. The feasibility study concluded "all resources studied were present and in sufficient quantity and quality to warrant consideration for development" and there were varying degrees of potential economic impact based on the resource type and project size. The feasibility study and its components were to be used as tools to attract potential developers and other business ventures to the local market. White Pine County also marketed the County’s resources to the renewable energy business community in an effort to develop contracts for demonstration projects. The County also worked to develop partnerships with local educational institutions, including the White Pine County School District, conducted outreach and training for the local community.

  3. Joint irrigation districts hydropower assessment study. Final feasibility assessment report. Volume I

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-02-01

    In August 1978, the United States Department of Energy and the Turlock Irrigation District entered into a cooperative agreement for a Joint District's Low-Head Hydropower Assessment Study. The purpose of the agreement was to carry out a study of the hydropower potential at sites within the borders of the Turlock, Merced, South San Joaquin, and Oakdale Irrigation Districts in California. The required data were gathered and analyzed. The results of this study indicate the total potential small hydropower capacity with the Joint Districts is 19,560 kW installed with an annual energy generation of 68,561,800 kWh. This is equivalent to oil-savings of 118,616 barrels per y.

  4. Seismic probabilistic risk assessment and its impact on margin studies

    International Nuclear Information System (INIS)

    In recent years a number of seismic probabilistic risk assessments of nuclear power plants have been conducted. These studies have highlighted the significance of seismic events to the overall plant risk and have identified several dominant contributors to the seismic risk. It has been learnt from the seismic PRAs that the uncertainty in the seismic hazard results contribute to the large uncertainty in the core damage and severe release frequencies. A procedure is needed to assess the seismic safety of a plant which is somewhat removed from the influence of the uncertainties in seismic hazard estimates. In the last two years, seismic margin review methodologies have been developed based on the results and insights from the seismic probabilistic risk assessments. They focus on the question of how much larger an earthquake should be beyond the plant design basis before it compromises the safety of the plant. An indicator of the plant seismic capacity called the High Confidence Low Probability of Failure (HCLPF) capacity, is defined as the level of earthquake for which one could state with high confidence that the plant will have a low probability of severe core damage. The seismic margin review methodologies draw from the seismic PRAs, experience in seismic analyses, testing and actual earthquakes in order to minimize the review effort. The salient steps in the review consists of preliminary screening of components and systems, performance of detailed seismic walkdowns and evaluation of seismic margins for components, systems and plant. (orig.)

  5. Environmental assessments in the US: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Doesburg, J.M.

    1992-05-01

    The 1990`s is the decade of international environmental activism. The concerns and issues that are the basis of this activism are now extremely important to business. Numerous environmental issue will affect business decisions, and a keen awareness of the implications of those issues may make the difference financial success or ruin. Environmental assessments have become the tool to help business cope with an important environmental concern. This talk is focused on environmental assessments as they are practiced in the United States. Environmental activism has been a factor in business decisions since the passage of the Clean Air Act in 1963. This paper will discuss the current standards of practice in the US, the needs for assessments at industrial facilities, and a case study from a US industrial facility. More than 750,000 commercial real estate transactions take place in the US each year. Each of these transactions has a potential liability for the buyer and lender as a result of environmental impairment caused by hazardous materials located in buildings on sites, in the soil, or in the groundwater. Persons who knowingly or unknowingly acquire environmentally impaired property or who lend the money to purchase that property are liable for the cost of cleanup.

  6. Environmental assessments in the US: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Doesburg, J.M.

    1992-05-01

    The 1990's is the decade of international environmental activism. The concerns and issues that are the basis of this activism are now extremely important to business. Numerous environmental issue will affect business decisions, and a keen awareness of the implications of those issues may make the difference financial success or ruin. Environmental assessments have become the tool to help business cope with an important environmental concern. This talk is focused on environmental assessments as they are practiced in the United States. Environmental activism has been a factor in business decisions since the passage of the Clean Air Act in 1963. This paper will discuss the current standards of practice in the US, the needs for assessments at industrial facilities, and a case study from a US industrial facility. More than 750,000 commercial real estate transactions take place in the US each year. Each of these transactions has a potential liability for the buyer and lender as a result of environmental impairment caused by hazardous materials located in buildings on sites, in the soil, or in the groundwater. Persons who knowingly or unknowingly acquire environmentally impaired property or who lend the money to purchase that property are liable for the cost of cleanup.

  7. Environmental performance assessment: a case study in the paper industry

    Directory of Open Access Journals (Sweden)

    Paula Antonov

    2011-09-01

    Full Text Available The inherent complexity of environmental performance measurement makes it difficult to be gauged, sending it forth to methodologies supported on assessments of the various factors that could influence the overall performance. In association with the environmental performance lies the need to create methods that allows the assessment over the time in order to facilitate comparisons amongst different organizations or operations of a same company. Measurement of environmental performance comes from several sources thus a dominant approach widely recognized and accepted by the academic community and organizations can not be singled out. The purpose of this review is to test a method for assessing environmental performance in a manufacturer organization, performing a case study in the paper industry. The results can be compared with other operations and can be used, cumulatively, in supply chains. The specific objectives are (i to model the environmental performance of the transaction, (ii to use the model to measure performance, and (iii to interpret the results and come to a conclusion. It begins with a review of the environmental performance measurement and then proceeds to the description of the research methodology and the results of its application. The method consists of five constructs, assessed by managers and processes experts according to their potential of environmental performance's improvement: solid waste, wastewater, gas emissions, deployment of natural resources, and legal compliance. The constructs are perceived by qualitative indicators categorically evaluated. The final result is an index of 76.69%, which represents the environmental performance of the operation.

  8. ASSESSMENT OF SURGICAL OUTCOMES OF RHINOPLASTY – A CLINICAL STUDY

    Directory of Open Access Journals (Sweden)

    Tanthry Deepalakshmi

    2015-12-01

    Full Text Available Rhinoplasty is one of the most common cosmetic surgery performed by the otorhinolaryngologists. The main indication for rhinoplasty is cosmetic or functional or both. In regard to paucity of research regarding patient satisfaction after surgery, we have done this prospective clinical study in our hospital. 40 patients were included in the study from January 2012 to December 2012. Rhinoplasty Outcomes Evaluation (ROE Questionnaire was applied to all the patients and evaluation of the satisfaction pre op and post operatively was assessed and the results were statistically analysed. The age of the study group ranged from 20 yrs to 39 yrs with the mean age of 24.85 +/- 3.43 years. The average satisfaction mark of patients undergoing rhinoplasty in pre-operative state was 28.05 & post-operative it improved and reached to 67.91.The average satisfaction of female were 26.75 preoperatively reached to 63.68 postoperatively. The average satisfaction of male were 31.2 preoperatively reached upto 67.91 post operatively. The degree of the satisfaction pre and post operatively was compared using student t test and paired t test. It was 67.91 in males and 36.53 among females which was statistically significant (p < 0.05. Patient satisfaction is as important as technical aspects of rhinoplasty. Hence a novel attempt is made in this direction to assess and understand patient expectations to achieve realistic goals in rhinoplasty.

  9. Assessment of international mitigation costing studies in developing countries

    International Nuclear Information System (INIS)

    The establishment of the Framework Convention on Climate change has motivated a large number of mitigation costing studies of developing countries. A variety of modelling approaches and input assumptions have been employed, and studies have been carried out by a range of institutions, including international research institutions, consultants and national organisations. This paper attempts to bring together the main results and characteristics of some of the major recent studies. In spite of the diversity of teams involved in the studies, the similarities in scenario definitions and in the bottom-up approach used for the energy sector analysis, enable some key macro indicators and results of the studies to be compared. Two main coordinated country study efforts have been carried out: by the Lawrence Berkeley Laboratory (LBL) and by UNEP collaborating Centre on Energy and Environment (UCCEE). The results and methodological framework of these country studies are assessed in relation to similar country study activities for China, West Africa and South East Asia in order to evaluate possible common conclusions. (au) 13 refs

  10. Life cycle assessment study of a Chinese desktop personal computer

    International Nuclear Information System (INIS)

    Associated with the tremendous prosperity in world electronic information and telecommunication industry, there continues to be an increasing awareness of the environmental impacts related to the accelerating mass production, electricity use, and waste management of electronic and electric products (e-products). China's importance as both a consumer and supplier of e-products has grown at an unprecedented pace in recent decade. Hence, this paper aims to describe the application of life cycle assessment (LCA) to investigate the environmental performance of Chinese e-products from a global level. A desktop personal computer system has been selected to carry out a detailed and modular LCA which follows the ISO 14040 series. The LCA is constructed by SimaPro software version 7.0 and expressed with the Eco-indicator'99 life cycle impact assessment method. For a sensitivity analysis of the overall LCA results, the so-called CML method is used in order to estimate the influence of the choice of the assessment method on the result. Life cycle inventory information is complied by ecoinvent 1.3 databases, combined with literature and field investigations on the present Chinese situation. The established LCA study shows that that the manufacturing and the use of such devices are of the highest environmental importance. In the manufacturing of such devices, the integrated circuits (ICs) and the Liquid Crystal Display (LCD) are those parts contributing most to the impact. As no other aspects are taken into account during the use phase, the impact is due to the way how the electricity is produced. The final process steps - i.e. the end of life phase - lead to a clear environmental benefit if a formal and modern, up-to-date technical system is assumed, like here in this study

  11. Pressurized thermal shock in nuclear power plants: Good practices for assessment. Deterministic evaluation for the integrity of reactor pressure vessel

    International Nuclear Information System (INIS)

    Starting in the early 1970s, a series of coordinated research projects (CRPs) was sponsored by the IAEA focusing on the effects of neutron radiation on reactor pressure vessel (RPV) steels and RPV integrity. In conjunction with these CRPs, many consultants meetings, specialists meetings, and international conferences, dating back to the mid-1960s, were held. Individual studies on the basic phenomena of radiation hardening and embrittlement were also performed to better understand increases in tensile strength and shifts to higher temperatures for the integrity of the RPV. The overall objective of this CRP was to perform benchmark deterministic calculations of a typical pressurized thermal shock (PTS) regime, with the aim of comparing the effects of individual parameters on the final RPV integrity assessment, and then to recommend the best practices for their implementation in PTS procedures. At present, several different procedures and approaches are used for RPV integrity assessment for both WWER 440-230 reactors and pressurized water reactors (PWRs). These differences in procedures and approaches are based, in principle, on the different codes and rules used for design and manufacturing, and the different materials used for the various types of reactor, and the different levels of implementation of recent developments in fracture mechanics. Benchmark calculations were performed to improve user qualification and to reduce the user effect on the results of the analysis. This addressed generic PWR and WWER types of RPV, as well as sensitivity analyses. The complementary sensitivity analyses showed that the following factors significantly influenced the assessment: flaw size, shape, location and orientation, thermal hydraulic assumptions and material toughness. Applying national codes and procedures to the benchmark cases produced significantly different results in terms of allowable material toughness. This was mainly related to the safety factors used and the

  12. Quality control for exposure assessment in epidemiological studies

    DEFF Research Database (Denmark)

    Bornkessel, C; Blettner, M; Breckenkamp, J;

    2010-01-01

    In the framework of an epidemiological study, dosemeters were used for the assessment of radio frequency electromagnetic field exposure. To check the correct dosemeter's performance in terms of consistency of recorded field values over the entire study period, a quality control strategy was...... developed. In this paper, the concept of quality control and its results is described. From the 20 dosemeters used, 19 were very stable and reproducible, with deviations of a maximum of +/-1 dB compared with their initial state. One device was found to be faulty and its measurement data had to be excluded...... from the analysis. As a result of continuous quality control procedures, the confidence in the measurements obtained during the field work was strengthened significantly....

  13. Fuel assembly assessment from CVD image analysis: A feasibility study

    International Nuclear Information System (INIS)

    The Swedish Nuclear Inspectorate commissioned a feasibility study of automatic assessment of fuel assemblies from images obtained with the digital Cerenkov viewing device currently in development. The goal is to assist the IAEA inspectors in evaluating the fuel since they typically have only a few seconds to inspect an assembly. We report results here in two main areas: Investigation of basic image processing and recognition techniques needed to enhance the images and find the assembly in the image; Study of the properties of the distributions of light from the assemblies to determine whether they provide unique signatures for different burn-up and cooling times for real fuel or indicate presence of non-fuel. 8 refs, 27 figs

  14. "Assessment of different bioequivalent metrics in Rifampin bioequivalence study "

    Directory of Open Access Journals (Sweden)

    "Rouini MR

    2002-08-01

    Full Text Available The use of secondary metrics has become special interest in bioequivalency studies. The applicability of partial area method, truncated AUC and Cmax/AUC has been argued by many authors. This study aims to evaluate the possible superiority of these metrics to primary metrics (i.e. AUCinf, Cmax and Tmax. The suitability of truncated AUC for assessment of absorption extent as well as Cmax/AUC and partial AUC for the evaluation of absorption rate in bioequivalency determination was investigated following administration of same product as test and reference to 7 healthy volunteers. Among the pharmacokinetic parameters obtained, Cmax/AUCinf was a better indicator or absorption rate and the AUCinf was more sensitive than truncated AUC in evaluation of absorption extent.

  15. Assessment and treatment of childhood topographical disorientation: a case study.

    Science.gov (United States)

    Brunsdon, Ruth; Nickels, Lyndsey; Coltheart, Max; Joy, Pamela

    2007-01-01

    Topographical disorientation refers to individuals who are unable to find their way around large-scale environments in a normal manner. Childhood topographical disorientation is rarely investigated or reported. Treatment of topographical disorientation is also rare with only one reported treatment study in an adult (Davis & Coltheart, 1999) and no known description of treatment in a child. This paper reports a detailed case analysis of CA, a 6-year-old child with topographical disorientation, and a description of a treatment programme focused on training orientation in the school environment. Assessment of CA revealed mild to moderate visual agnosia in conjunction with severe impairments in general spatial learning and memory, topographical new learning and memory, and a total inability to learn new topographical routes. CA was also unable to use a mental image of his environment, a simple visual plan of his environment or a simple visual map, but was able to follow verbally mediated topographical instructions. The treatment programme focused on improving CA's topographical orientation in the school environment. The programme first involved training in recognition of major school buildings and landmarks and then focused on practical training in route finding along commonly used routes in the school environment. Clear benefits from treatment were evident. The assessment and treatment methods employed provide practical and useful ideas for management of this condition in other children. PMID:17178605

  16. Development and Implementation of Health Technology Assessment: A Policy Study

    Directory of Open Access Journals (Sweden)

    P Abooee

    2013-01-01

    Full Text Available Background: To provide an overview of the development of health technology assessment (HTA in Iran since 2007, and to facilitate further development of HTA and its integration into policy making.Methods: Data of this study were collected through key documents (e.g. literature, laws, and other official documentation and analyzed by experts of opinion in form of qualitative methods.Results: Health technology assessment entered to the political agenda in Iran only in 2007 with a strong impetus of an evidence-based medicine movement with the bellow objectives: Institutionalization of evidence-based decision making in Ministry of Health, Creating an localization for structural HTA in Health system of Iran, Setting up training courses in order to educate capable manpower to full up the capacity of the universities, Establishment of a new field in HTA subject in medical universities for MSc and PhD degree, International communication about HTA through national website and possible participation in international Congress.Conclusion: HTA has been established in the healthcare system of Iran but what is needed is a clear political will to push forward the objectives of HTA in Iran. Similar to other countries, advance the regulation on the adoption of new health technologies to improve not only technical or allocate efficiency, but also health equity.

  17. Pain assessment in animal models: do we need further studies?

    Directory of Open Access Journals (Sweden)

    Gigliuto C

    2014-05-01

    Full Text Available Carmelo Gigliuto,1 Manuela De Gregori,2 Valentina Malafoglia,3 William Raffaeli,3 Christian Compagnone,4 Livia Visai,5,6 Paola Petrini,7 Maria Antonietta Avanzini,9 Carolina Muscoli,8 Jacopo Viganò,11 Francesco Calabrese,11 Tommaso Dominioni,11 Massimo Allegri,2,10 Lorenzo Cobianchi111Anaesthesia and Intensive Care, University of Pavia, Pavia, 2Pain Therapy Service, Fondazione IRCCS Policlinico San Matteo, Pavia, 3ISAL Foundation, Institute for Research on Pain, Torre Pedrera, Rimini, 4Department of Anaesthesia, Intensive Care and Pain Therapy, Azienda Ospedaliera Universitaria Parma, University of Parma, Parma, 5Department of Molecular Medicine, Center for Tissue Engineering (CIT, INSTM UdR of Pavia, University of Pavia, Pavia, 6Department of Occupational Medicine, Ergonomy and Disability, Laboratory of Nanotechnology, Salvatore Maugeri Foundation, IRCCS, Veruno, 7Dipartimento di Chimica, Materiali e Ingegneria Chimica 'G Natta' and Unità di Ricerca Consorzio INSTM, Politecnico di Milano, Milan, 8Department of Health Science, University Magna Grecia of Catanzaro and Centro del Farmaco, IRCCS San Raffaele Pisana, Roma, 9Laboratory of Transplant Immunology/Cell Factory, Fondazione IRCCS Policlinico "San Matteo", Pavia, 10Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, 11University of Pavia, Department of Surgical, Clinical, Paediatric and Diagnostic Science, General Surgery 1, IRCCS Fondazione Policlinico San Matteo, Pavia, ItalyAbstract: In the last two decades, animal models have become important tools in understanding and treating pain, and in predicting analgesic efficacy. Although rodent models retain a dominant role in the study of pain mechanisms, large animal models may predict human biology and pharmacology in certain pain conditions more accurately. Taking into consideration the anatomical and physiological characteristics common to man and pigs (median body size, digestive apparatus

  18. Assessment of global phase uncertainty in case-control studies

    Directory of Open Access Journals (Sweden)

    van Houwelingen Hans C

    2009-09-01

    Full Text Available Abstract Background In haplotype-based candidate gene studies a problem is that the genotype data are unphased, which results in haplotype ambiguity. The measure 1 quantifies haplotype predictability from genotype data. It is computed for each individual haplotype, and for a measure of global relative efficiency a minimum value is suggested. Alternatively, we developed methods directly based on the information content of haplotype frequency estimates to obtain global relative efficiency measures: and based on A- and D-optimality, respectively. All three methods are designed for single populations; they can be applied in cases only, controls only or the whole data. Therefore they are not necessarily optimal for haplotype testing in case-control studies. Results A new global relative efficiency measure was derived to maximize power of a simple test statistic that compares haplotype frequencies in cases and controls. Application to real data showed that our proposed method gave a clear and summarizing measure for the case-control study conducted. Additionally this measure might be used for selection of individuals, who have the highest potential for improving power by resolving phase ambiguity. Conclusion Instead of using relative efficiency measure for cases only, controls only or their combined data, we link uncertainty measure to case-control studies directly. Hence, our global efficiency measure might be useful to assess whether data are informative or have enough power for estimation of a specific haplotype risk.

  19. [Economic assessment, a field between clinical research and observational studies].

    Science.gov (United States)

    Launois, Robert

    2003-01-01

    Health technology assessments propose to study the differential impact of health interventions in a complex care system which is characterised by the multitude of individual behaviours and the diverse nature of the institutions involved. Current systems for data collection lend themselves poorly to this rigorous analysis of efficacy of treatments in the actual situations where they are used. Randomised trials endeavour to neutralise any parasitic interference which could compromise testing for a causal relationship between the treatment administered and the result obtained. Their methodology which establishes the term ceteris paribus in the principle of good practice lends itself poorly to an analysis of individual behaviour. Observational studies are start from actual treatment situations to describe them as reliably as possible. By definition, however, these assume that the natural course of events is not deviated by any intervention. The absence of an experimental plan increases the likelihood of bias and makes it more difficult to test for causal relationships. They lend themselves poorly to testing for incremental efficacy. The two instruments to be preferred are decisional analysis and quasi-experimental studies. Decisional analysis help to avoid the problems of external validity associated with randomised clinical trials by associating parameters which are extracted from data obtained from everyday practice. Quasi-experimental studies or pragmatic trials are based on the reality of behaviour of the prescriber and his/her patients; their impact on efficacy, quality of life social costs of the disease and of treatments may be identified under normal conditions of use. PMID:12609811

  20. An Assessment of Air Pollution Exposure Information for Health Studies

    Directory of Open Access Journals (Sweden)

    Frederick W. Lipfert

    2015-11-01

    Full Text Available Most studies of air pollution health effects are based on outdoor ambient exposures, mainly because of the availability of population-based data and the need to support emission control programs. However, there is also a large body of literature on indoor air quality that is more relevant to personal exposures. This assessment attempts to merge these two aspects of pollution-related health effects, emphasizing fine particles. However, the basic concepts are applicable to any pollutant. The objectives are to examine sensitivities of epidemiological studies to the inclusion of personal exposure information and to assess the resulting data requirements. Indoor air pollution results from penetration of polluted outdoor air and from various indoor sources, among which environmental tobacco smoke (ETS is probably the most toxic and pervasive. Adequate data exist on infiltration of outdoor air but less so for indoor sources and effects, all of which have been based on surveys of small samples of individual buildings. Since epidemiology is based on populations, these data must be aggregated using probabilistic methods. Estimates of spatial variation and precision of ambient air quality are also needed. Hypothetical personal exposures in this paper are based on ranges in outdoor air quality, variable infiltration rates, and ranges of indoor source strength. These uncertainties are examined with respect to two types of mortality studies: time series analysis of daily deaths in a given location, and cross-sectional analysis of annual mortality rates among locations. Regressions of simulated mortality on personal exposures, as affected by all of these uncertainties, are used to examine effects on dose-response functions using quasi-Monte Carlo methods. The working hypothesis is that indoor sources are reasonably steady over time and thus applicable only to long-term cross-sectional studies. Uncertainties in exposure attenuate the simulated mortality

  1. Assessing maternal healthcare inequities among migrants: a qualitative study

    Directory of Open Access Journals (Sweden)

    Ligia Moreira Almeida

    2014-02-01

    Full Text Available Considering pregnancy and motherhood as periods of increased vulnerability in migrant women, to characterize the healthcare provided to this collective, we sought to identify and understand patterns of satisfaction and demand of maternal and child healthcare, assessing women’s perceptions about its quality. The study followed a qualitative methodology (semi-structured interviews for collecting and analysing data (content analysis and was conducted in Porto, the second largest city of Portugal. Participants were 25 recent immigrant mothers from Eastern European countries, Brazil, Portuguese-speaking African countries and six native Portuguese recent mothers (for comparison, contacted through social associations and institutions. Data suggests that healthcare depends not only on accessibility but especially on social opportunities. Equitable public health action must provide individuals and groups the equal opportunity to meet their needs, which may not be achieved by providing the same standard if care to all.

  2. Integrated assessment in the Mediterranean: the CIRCE case studies

    Science.gov (United States)

    Goodess, C. M.; Agnew, M. D.; Hemming, D.; Giannakopoulos, C.

    2012-04-01

    The heterogeneous nature of the Mediterranean environment, combined with a wide diversity of economic, social and cultural identities, make this region particularly amenable to integrated research on climate change impacts, vulnerabilities, and adaptive response. Within the framework of the EU FP7 CIRCE project, eleven case-study locations were selected to reflect three generic environments (urban, rural and coastal), to quantify current and future climate change and to assess the potential consequences to human communities and ecosystems at the regional to local scale. The case studies (Athens, Beirut, Alexandria, Tuscany, Apulia, Tel Hadya, Judean Foothills, Gulf of Valencia, Gulf of Oran, Gulf of Gabes, West Nile Delta) were chosen to reflect the east-west and north-south contrasts across the Mediterranean, using common selection criteria. A rigorous common framework, referred to as the CIRCE Case studies Integrating Framework was developed to facilitate a structured and systematic basis for identifying and selecting indicators. Within this framework, climate dynamics is viewed as a key driver of changes in social and biogeophysical systems and is modulated by the inherent dynamics of these systems. The top-down, indicator-based approach was complemented by a bottom-up approach involving local and regional stakeholders. A participatory level of involvement was aimed for, with stakeholder dialogue on an informal basis throughout the project, culminating in a series of more formal regional stakeholder workshops. Identification and construction of physical and socio-economic indicators was the most challenging and time-consuming aspect of the case-study work. A detailed set of selection criteria was defined and the process of reviewing and refining indicators was iterative. Nonetheless, a number of data and methodological challenges were encountered. Despite these issues, indicator linkages diagrams provided a useful preparatory stage for structuring the integrated

  3. Scaling studies and conceptual experiment designs for NGNP CFD assessment

    Energy Technology Data Exchange (ETDEWEB)

    D. M. McEligot; G. E. McCreery

    2004-11-01

    The objective of this report is to document scaling studies and conceptual designs for flow and heat transfer experiments intended to assess CFD codes and their turbulence models proposed for application to prismatic NGNP concepts. The general approach of the project is to develop new benchmark experiments for assessment in parallel with CFD and coupled CFD/systems code calculations for the same geometry. Two aspects of the complex flow in an NGNP are being addressed: (1) flow and thermal mixing in the lower plenum ("hot streaking" issue) and (2) turbulence and resulting temperature distributions in reactor cooling channels ("hot channel" issue). Current prismatic NGNP concepts are being examined to identify their proposed flow conditions and geometries over the range from normal operation to decay heat removal in a pressurized cooldown. Approximate analyses have been applied to determine key non-dimensional parameters and their magnitudes over this operating range. For normal operation, the flow in the coolant channels can be considered to be dominant turbulent forced convection with slight transverse property variation. In a pressurized cooldown (LOFA) simulation, the flow quickly becomes laminar with some possible buoyancy influences. The flow in the lower plenum can locally be considered to be a situation of multiple hot jets into a confined crossflow -- with obstructions. Flow is expected to be turbulent with momentumdominated turbulent jets entering; buoyancy influences are estimated to be negligible in normal full power operation. Experiments are needed for the combined features of the lower plenum flows. Missing from the typical jet experiments available are interactions with nearby circular posts and with vertical posts in the vicinity of vertical walls - with near stagnant surroundings at one extreme and significant crossflow at the other. Two types of heat transfer experiments are being considered. One addresses the "hot channel" problem, if necessary

  4. Valdez air health study - Exposure monitoring and risk assessment

    International Nuclear Information System (INIS)

    In Valdez, Alaska there is concern about exposure of the public to benzene and other light hydrocarbons emitted during the loading of tankers from the Trans-Alaska Pipeline. As part of an overall risk assessment, the Valdez Air Health Study, a personal, indoor and outdoor air sampling program patterned after EPA's TEMA Study was designed and carried out. A unique feature of the study is that, during sampling periods, SF6 tracer was released at the terminal site to represent terminal hydrocarbon emissions to provide a basis for directly quantitating any contribution of terminal emissions to personal exposure. Sixty citizens at Valdez were selected to wear vests containing sampling equipment for 24-hour periods summer and winter. At the homes of 30 of the participants simultaneous indoor and outdoor samples for hydrocarbons and tracer were collected during the period that each participant collected personal air samples. The paper reviews the design of the program, details of the procedures used, results of the August, 1990 program and preliminary results from the February-March, 1991 program

  5. Evaluation of patients with gall bladder (GB) cancer using FDG PET

    International Nuclear Information System (INIS)

    Even with advanced diagnostic imaging, difficulties have been encountered in correct evaluation of GB malignancy. This study was undertaken to assess the role of FDG PET in patients with GB cancer. Twenty-seven pts (13 F, 14 M, a mean age of 60 yr.) were included in this study. Fourteen pts were evaluated for staging and 13 pts were for suspected recurrent or residual tumors. All pts underwent FDG PET and other conventional imaging such as radiography, US, CT, MRI, or bone scintigraphy within a month of period. Of the 14 pts at staging, FDG PET was concordant with conventional imaging in 9 pts. In the rest of 5 pts with discordant results, PET identified extra-abdominal metastasis in 4 pts whereas conventional imaging detected peritoneal carcinomatosis in 1 pt. Of the 13 pts with suspected recurrent or residual tumors, findings on PET were concordant with those on conventional imaging in 6 pts (4 concordant positive, 1 concordant negative, 1 concordant false positive). Discordant results were found in 7 of the 13 pts. FDG PET was superior to conventional imaging in detecting local and distant diseases in 6 of 7 pts. FDG PET has an advantage of detecting unsuspected distant metastasis at staging. During follow-up, FDG PET is useful in identifying both local and distant residual and/or recurrent diseases. The use of FDG PET appears to have significant diagnostic and therapeutic implication in the evaluation of this aggressive malignancy in the GB

  6. A field study comparing two methods of transportation risk assessment

    International Nuclear Information System (INIS)

    RADTRAN 4 is a computer code used for; assessing risks associated with the transportation of nuclear materials. The code employs the common modeling practice of using default values for input variables to simplify the modeling of complex scenarios, thus producing conservative final risk determinations. To better address local public concerns it is of interest to quantify the introduced conservatism by taking a site-specific approach to radiation risk assessment. With RISKIND, incident-free and accident condition doses were calculated for two suburban population groups using both default input parameters; and site-specific values to describe population demographics of regions in Pocatello, Idaho, along the I-15 corridor. The use of site-specific parameters resulted in incident-free doses ranging from the same order of magnitude to one order of magnitude less than the doses calculated with default input parameters. Correcting accident condition doses for the age distribution of the populations and employing site-specific weather data resulted in doses 1.1 times lower than estimated using default input parameters. Dose-risks calculated with RISKIND for the two population groups using site-specific data were of the same order of magnitude as the risk calculated using RADTRAN 4 for the suburban population described in DOE/EIS-0203-D. This study revealed in one specific application that use of default and site-specific parameters resulted in comparable dose estimates. If this tendency were to hold generally true over other environments and model variables, then risk assessors might prefer to select codes on the basis of criteria such as (1) the number of variables to select from; (2) ability to calculate consequences directly, and (3) outputs geared to addressing public concerns

  7. Life cycle assessment of active and passive groundwater remediation technologies

    Science.gov (United States)

    Bayer, Peter; Finkel, Michael

    2006-02-01

    Groundwater remediation technologies, such as pump-and-treat (PTS) and funnel-and-gate systems (FGS), aim at reducing locally appearing contaminations. Therefore, these methodologies are basically evaluated with respect to their capability to yield local improvements of an environmental situation, commonly neglecting that their application is also associated with secondary impacts. Life cycle assessment (LCA) represents a widely accepted method of assessing the environmental aspects and potential impacts related to a product, process or service. This study presents the set-up of a LCA framework in order to compare the secondary impacts caused by two conceptually different technologies at the site of a former manufactured gas plant in the city of Karlsruhe, Germany. As a FGS is already operating at this site, a hypothetical PTS of the same functionality is adopted. During the LCA, the remediation systems are evaluated by focusing on the main technical elements and their significance with respect to resource depletion and potential adverse effects on ecological quality, as well as on human health. Seven impact categories are distinguished to address a broad spectrum of possible environmental loads. A main point of discussion is the reliability of technical assumptions and performance predictions for the future. It is obvious that a high uncertainty exists when estimating impact specific indicator values over operation times of decades. An uncertainty analysis is conducted to include the imprecision of the underlying emission and consumption data and a scenario analysis is utilised to contrast various possible technological variants. Though the results of the study are highly site-specific, a generalised relative evaluation of potential impacts and their main sources is the principle objective rather than a discussion of the calculated absolute impacts. A crucial finding that can be applied to any other site is the central role of steel, which particularly derogates

  8. Application of radionuclide techniques in evaluation of dilated cardiomyopathy and ischemic cardiomyopathy

    International Nuclear Information System (INIS)

    Objective: To assess the clinical significance of radionuclide techniques in differentiating dilated cardiomyopathy (DCM) from ischemic cardiomyopathy (CAD-CM). Methods: 28 patients (pts) with DCM and 55 pts with CAD-CM were studied. All pts underwent 99Tcm-MIBI myocardial perfusion SPECT and 18F-FDG myocardial metabolic PET. 73 pts had 99Tcm-RBC radionuclide ventriculography and 68 pts had coronary angiography. Results: 23 pts (82%) with DCM showed perfusion abnormalities with mild and not segmental distribution. 52 pts (95%) with CAD-CM showed perfusion abnormalities that distributed along the coronary vessel territories. Perfusion defects were found in 4 pts (14%) with DCM and 45 pts (82%) with CAD-CM (P<0.01). The average perfusion score was 4.5 +- 2.6 in DCM and 9.5 +- 2.9 in CAD-CM, the area of perfusion diminished uptake was significantly smaller in DCM than in CAD-CM (P < 0.001). 2 pts with DCM and 18 pts with CAD-CM had metabolic defect. The patterns of perfusion/metabolic imaging showed mismatch in most pts with CAD-CM but match in pts with DCM. The LVEF in pts with DCM and CAD-CM was decreased but no significant difference between DCM and CAD-CM was observed. The RVEF in pts with DCM was significantly lower than that in pts with CAD-CM (32.4% +- 13.9% vs 40.9% +- 15.4%, P < 0.05). Conclusions: The radionuclide techniques showed to be helpful for distinguishing DCM from CAD-CM. The discriminate analysis revealed that segmental perfusion abnormality and RVEF were the most important factors for differentiation of DCM from CAD-CM

  9. Assessment of Corporate Governance in Jordan: An Empirical Study

    Directory of Open Access Journals (Sweden)

    Sinan S. Abbadi

    2011-09-01

    Full Text Available This paper assesses the reality of corporate governance in Jordan. It identifies the framework of corporate governance, which has here been set into two dimensions – institutionalisations and regulations – and describes the five major principles of corporate governance. The study was carried out by interviews with key employees and the review of related laws and selected annual reports. The study found (1 basic shareholder rights were honoured in decision-making, except for large decisions such as major asset sales; (2 shareholders were not treated equitably in practice, although controllers sometimes took action and prohibited insider trading; (3 the role and rights of stakeholders in corporate governance were respected, and stakeholders had a number of legal protections, which were largely covered in Jordan's Company Law; (4 disclosure and transparency were observed to a large extent, although limited to quantity rather than quality, because Jordan has fully adopted IFRS and ISA and (5 boards largely fulfilled their responsibilities, as these are extensively defined by law and regulation.

  10. Recent case studies and advancements in probabilistic risk assessment

    International Nuclear Information System (INIS)

    During the period from 1977 to 1984, Pickard, Lowe and Garrick, Inc., had the lead in preparing several full scope probabilistic risk assessments for electric utilities. Five of those studies are discussed from the point of view of advancements and lessons learned. The objective and trend of these studies is toward utilization of the risk models by the plant owners as risk management tools. Advancements that have been made are in presentation ad documentation of the PRAs, generation of more understandable plant level information, and improvements in methodology to facilitate technology transfer. Specific areas of advancement are in the treatment of such issues as dependent failures, human interaction, and the uncertainty in the source term. Lessons learned cover a wide spectrum and include the importance of plant specific models for meaningful risk management, the role of external events in risk, the sensitivity of contributors to choice of risk index, and the very important finding that the public risk is extremely small. The future direction of PRA is to establish less dependence on experts for in-plant application. Computerizing the PRAs such that they can be accessed on line and interactively is the key

  11. Thermodynamic assessment and experimental study of Mg–Gd alloys

    Energy Technology Data Exchange (ETDEWEB)

    Hampl, M. [Institute of Metallurgy, Clausthal University of Technology, Robert-Koch-Str. 42, D-38678 Clausthal-Zellerfeld (Germany); Blawert, C.; Silva Campos, M.R.; Hort, N.; Peng, Q.; Kainer, K.U. [Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Magnesium Innovation Centre, Max-Planck-Straße 1, D-21502 Geesthacht (Germany); Schmid-Fetzer, R., E-mail: schmid-fetzer@tu-clausthal.de [Institute of Metallurgy, Clausthal University of Technology, Robert-Koch-Str. 42, D-38678 Clausthal-Zellerfeld (Germany)

    2013-12-25

    Highlights: •Solid solubity of Gd in (Mg) experimentally studied. •Consistent thermodynamic calculation of Mg–Gd phase diagram developed. •Vapor pressure and enthalpy of formation data analyzed by Calphad method. •Three error sources identified in earlier approximate enthalpy derivation. •Claimed systematic trends in enthalpies of formation disputed. -- Abstract: The solid solubility of Gd in (Mg) is studied experimentally using microstructure, chemical and EDX analysis on permanent mould chill cast samples which were annealed for 1–14 days at 300–550 °C. Based on those key data and all the critically assessed experimental phase equilibrium and thermodynamic data of the Mg–Gd system two Calphad-type thermodynamic descriptions are developed. This provides calculated phase diagrams, and an inherent inconsistency between the vapor pressure data and the Mg-rich phase diagram is indicated. A previous misperception of “experimental” enthalpy of formation data of binary Gd{sub x}Mg{sub y} intermetallic compounds is also revealed. The assumption of systematic trends in these key thermodynamic data for the series of rare earth elements R = (La, Ce, Pr, Nd, Sm, Gd) is scrutinized.

  12. Quick assessment of hopelessness: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Cheung Yin

    2006-03-01

    Full Text Available Abstract Background Lengthy questionnaires reduce data quality and impose a burden on respondents. Previous researchers proposed that a single item ("My future seems dark to me" and a 4-item component of the Beck's Hopelessness Scale (BHS can summarise most of the information the BHS provides. There is no clear indication of what BHS cutoff values are useful in identifying people with suicide tendency. Methods In a population-based study of Chinese people aged between 15 and 59 in Hong Kong, the Chinese version of the BHS and the Centre for Epidemiologic Studies – Depression scale were administered by trained interviewers and suicidal ideation and suicidal attempts were self-reported. Receiver operating characteristics curve analysis and regression analysis were used to compare the performance of the BHS and its components in identifying people with suicidality and depression. Smoothed level of suicidal tendency was assessed in relation to scores on the BHS and its component to identify thresholds. Results It is found that the 4-item component and, to a lesser extent, the single item of the BHS perform in ways similar to the BHS. There are non-linear relationship between suicidality and scores on the BHS and the 4-item component; cutoff values identified accordingly have sensitivity and specificity of about 65%. Conclusion The 4-item component is a useful alternative to the BHS. Shortening of psycho-social measurement scales should be considered in order to reduce burden on patients or respondents and to improve response rate.

  13. Assessment study of lichenometric methods for dating surfaces

    Science.gov (United States)

    Jomelli, Vincent; Grancher, Delphine; Naveau, Philippe; Cooley, Daniel; Brunstein, Daniel

    2007-04-01

    In this paper, we discuss the advantages and drawbacks of the most classical approaches used in lichenometry. In particular, we perform a detailed comparison among methods based on the statistical analysis of either the largest lichen diameters recorded on geomorphic features or the frequency of all lichens. To assess the performance of each method, a careful comparison design with well-defined criteria is proposed and applied to two distinct data sets. First, we study 350 tombstones. This represents an ideal test bed because tombstone dates are known and, therefore, the quality of the estimated lichen growth curve can be easily tested for the different techniques. Secondly, 37 moraines from two tropical glaciers are investigated. This analysis corresponds to our real case study. For both data sets, we apply our list of criteria that reflects precision, error measurements and their theoretical foundations when proposing estimated ages and their associated confidence intervals. From this comparison, it clearly appears that two methods, the mean of the n largest lichen diameters and the recent Bayesian method based on extreme value theory, offer the most reliable estimates of moraine and tombstones dates. Concerning the spread of the error, the latter approach provides the smallest uncertainty and it is the only one that takes advantage of the statistical nature of the observations by fitting an extreme value distribution to the largest diameters.

  14. Bridging probabilistic safety assessment studies with information Management System

    International Nuclear Information System (INIS)

    Probabilistic Safety Assessment (PSA) is a critical business often known in conjunction with either new build or life extension of nuclear power plant. However, it is not so often referred to the operation phase of the plant, although it could bring a lot of long term benefits to the operator. The purpose of this paper is to discuss the potential contribution of PSA with day to day operation in bridging the deficiencies and specific failures characteristics of critical Structure System and Component (SSC) with the results of PSA studies. From and Information System prospective, the use of Information Management system (IMS) -also known as EAM solution -widely used by the majority of nuclear operators- is the potential vehicle to bridge the 2 worlds of PSA and daily operation. Most EAM solution get reliability management functionalities which are not really integrated with PSA tools and data and thus cannot provide the anticipated benefits of addressing typical aging phenomena beyond the only predictive models used by the PSA studies. The paper will also discuss potential integration scenario between PSA tools and EAM solutions. (authors)

  15. Comparative study for environmental assessment by program characters

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Suk Chul; Lee, Young Soo; Park, Young Min; Park, Suk Soon; Chung, Kyung Tae; Cho, Hong Yun; Chae, Jang Won; Lee, Sang Don; Lee, Chan Ho; Choi, Joon Kyu; Kim, Kang Joo; Chung, Won Moo; Jin, Jae Yool [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    The level of environmental assessment in Korea was diagnosed by examining the situation of its model for the entire environmental assessment implemented. Also, it proposed an improvement scheme for its problems to be able to advance. It is expected to be utilized as developing optimum model for Korea and establishing a systematic and concrete guideline for environmental assessment modeling. 244 refs., 65 figs., 28 tabs.

  16. A Case Study of Teacher Personal Practice Assessment Theories and Complexities of Implementing Formative Assessment

    Science.gov (United States)

    Box, Cathy; Skoog, Gerald; Dabbs, Jennifer M.

    2015-01-01

    The value and effectiveness of formative assessment in the classroom has gained an increasing amount of attention during the past decade, especially since the publication of seminal work by Black and Wiliam titled "Assessment and Classroom Learning." Since that time, there has been a renewed interest in describing and evaluating teacher…

  17. Thermal Comfort Assessment: A Case Study at Malaysian Automotive Industry

    Directory of Open Access Journals (Sweden)

    A. R. Ismail

    2009-01-01

    Full Text Available Problem statement: Thermal comfort has a great influence on the productivity and satisfaction of indoor building occupants. The exposure to excessive heat during work may cause discomfort and contributed to low productivity among workers. Malaysia known with its hot and humid weather where in most of the survey study published indicated that workers in Malaysia automotive industries had exposed to excessive temperature while working. The study investigated the thermal comfort level experienced by workers at Malaysian automotive industry. Approach: The study had been conducted at one automotive parts assembly factory in Malaysia. The human subjects for the study constitute operators at tire receiving section of the factory. The environment examined was the relative humidity (%, WBGT, air temperature and radiant temperature (°C of the surrounding workstation area. The environmental factors were measured using Babuc apparatus, which is capable to measure simultaneously those mentioned environmental factors. The time series data of fluctuating level of factors were plotted to identify the significant changes of factors. Then thermal comfort of the workers was assessed by using ASHRAE thermal sensation scale by using Predicted Mean Vote (PMV. Further Predicted Percentage Dissatisfied (PPD was used to estimate the thermal comfort satisfaction of the occupant. Finally the PPD versus PMV were plotted to present the thermal comfort scenario of workers involved in related workstation. Results: The trend of relative humidity curve from the graph also indicated the increasing level of discomfort. The radiant temperature observed seems consistent during the study while there was decreasing of WBGT start from afternoon due to the rain. The study revealed that the PPD value of 54% of the workers population at the workstation are likely to be satisfied with thermal comfort at this station while the PMV index from ASHRAE indicated the value 1

  18. Study Addiction – A New Area of Psychological Study: Conceptualization, Assessment, and Preliminary Empirical Findings

    Science.gov (United States)

    Atroszko, Paweł A.; Andreassen, Cecilie Schou; Griffiths, Mark D.; Pallesen, Ståle

    2015-01-01

    Aims Recent research has suggested that for some individuals, educational studying may become compulsive and excessive and lead to ‘study addiction’. The present study conceptualized and assessed study addiction within the framework of workaholism, defining it as compulsive over-involvement in studying that interferes with functioning in other domains and that is detrimental for individuals and/or their environment. Methods The Bergen Study Addiction Scale (BStAS) was tested – reflecting seven core addiction symptoms (salience, mood modification, tolerance, withdrawal, conflict, relapse, and problems) – related to studying. The scale was administered via a cross-sectional survey distributed to Norwegian (n = 218) and Polish (n = 993) students with additional questions concerning demographic variables, study-related variables, health, and personality. Results A one-factor solution had acceptable fit with the data in both samples and the scale demonstrated good reliability. Scores on BStAS converged with scores on learning engagement. Study addiction (BStAS) was significantly related to specific aspects of studying (longer learning time, lower academic performance), personality traits (higher neuroticism and conscientiousness, lower extroversion), and negative health-related factors (impaired general health, decreased quality of life and sleep quality, higher perceived stress). Conclusions It is concluded that BStAS has good psychometric properties, making it a promising tool in the assessment of study addiction. Study addiction is related in predictable ways to personality and health variables, as predicted from contemporary workaholism theory and research. PMID:26014668

  19. Assessing function in patients undergoing joint replacement: a study protocol for a cohort study

    Directory of Open Access Journals (Sweden)

    Wylde Vikki

    2012-11-01

    Full Text Available Abstract Background Joint replacement is an effective intervention for people with advanced arthritis, although there is an important minority of patients who do not improve post-operatively. There is a need for robust evidence on outcomes after surgery, but there are a number of measures that assess function after joint replacement, many of which lack any clear theoretical basis. The World Health Organisation has introduced the International Classification of Functioning, Disability and Health (ICF, which divides function into three separate domains: Impairment, activity limitations and participation restrictions. The aim of this study is to compare the properties and responsiveness of a selection of commonly used outcome tools that assess function, examine how well they relate to the ICF concepts, and to explore the changes in the measures over time. Methods/design Two hundred and sixty three patients listed for lower limb joint replacement at an elective orthopaedic centre have been recruited into this study. Participants attend the hospital for a research appointment prior to surgery and then at 3-months and 1-year after surgery. At each assessment time, function is assessed using a range of measures. Self-report function is assessed using the WOMAC, Aberdeen Impairment, Activity Limitation and Participation Restriction Measure, SF-12 and Measure Yourself Medical Outcome Profile 2. Clinician-administered measures of function include the American Knee Society Score for knee patients and the Harris Hip Score for hip patients. Performance tests include the timed 20-metre walk, timed get up and go, sit-to-stand-to-sit, step tests and single stance balance test. During the performance tests, participants wear an inertial sensor and data from motion analysis are collected. Statistical analysis will include exploring the relationship between measures describing the same ICF concepts, assessing responsiveness, and studying changes in measures over

  20. Case study applications of the BASINS climate assessment tool (CAT)

    Science.gov (United States)

    This EPA report will illustrate the application of different climate assessment capabilities within EPA’s BASINS modeling system for assessing a range of potential questions about the effects of climate change on streamflow and water quality in different watershed settings and us...

  1. Exploring assessment factors contributing to students' study strategies: literature review.

    NARCIS (Netherlands)

    Al-Kadri, H.M.; Al-Moamary, M.S.; Roberts, C.; Vleuten, C.P.M. van der

    2012-01-01

    "Assessment steers students' learning" is a statement that has been used repeatedly without solid evidence in the literature. This manuscript aims to evaluate the published literatures on the effect of teaching learning environment in particular, the implemented assessment on students' learning appr

  2. Academic Advising Assessment Practices: Results of a National Study

    Science.gov (United States)

    Powers, Keith L.; Carlstrom, Aaron H.

    2014-01-01

    Best practices of academic advising assessment involve identification of student learning outcomes, the development and use of multiple measures of student learning, and sound professional judgment to understand the information gathered and to improve student learning. However, the assessment results often come from minimal, narrow, and…

  3. Voice Assessment of Student Work: Recent Studies and Emerging Technologies

    Science.gov (United States)

    Eckhouse, Barry; Carroll, Rebecca

    2013-01-01

    Although relatively little attention has been given to the voice assessment of student work, at least when compared with more traditional forms of text-based review, the attention it has received strongly points to a promising form of review that has been hampered by the limits of an emerging technology. A fresh review of voice assessment in light…

  4. Study of occupation health risk assessment on Chinese coal mine

    Institute of Scientific and Technical Information of China (English)

    XIAO Guo-qing; YAN Xiang-nong

    2007-01-01

    Factors of occupation health hazard were identified and analyzed, and indexes system of occupation health risk assessment were established by applying fuzzy theory and system safety technique, the weights of index system were obtained by AHP, finally a reasonable mathematics model of occupation health risk assessment was accomplished by an example.

  5. An Action Research Study: Engaging in Authentic Formative Assessment

    Science.gov (United States)

    Drost, Bryan R.

    2012-01-01

    Effective teaching in the United States over the last decade has been based on student performance on standardized tests (Darling-Hammond, 2010). Many school districts, in attempts to make gains on standardized assessments, have implemented standardized formative assessment procedures that dictate intervention for students not making gains…

  6. Scaling studies and conceptual experiment designs for NGNP CFD assessment

    International Nuclear Information System (INIS)

    The objective of this report is to document scaling studies and conceptual designs for flow and heat transfer experiments intended to assess CFD codes and their turbulence models proposed for application to prismatic NGNP concepts. The general approach of the project is to develop new benchmark experiments for assessment in parallel with CFD and coupled CFD/systems code calculations for the same geometry. Two aspects of the complex flow in an NGNP are being addressed: (1) flow and thermal mixing in the lower plenum (''hot streaking'' issue) and (2) turbulence and resulting temperature distributions in reactor cooling channels (''hot channel'' issue). Current prismatic NGNP concepts are being examined to identify their proposed flow conditions and geometries over the range from normal operation to decay heat removal in a pressurized cooldown. Approximate analyses have been applied to determine key non-dimensional parameters and their magnitudes over this operating range. For normal operation, the flow in the coolant channels can be considered to be dominant turbulent forced convection with slight transverse property variation. In a pressurized cooldown (LOFA) simulation, the flow quickly becomes laminar with some possible buoyancy influences. The flow in the lower plenum can locally be considered to be a situation of multiple hot jets into a confined crossflow--with obstructions. Flow is expected to be turbulent with momentum dominated turbulent jets entering; buoyancy influences are estimated to be negligible in normal full power operation. Experiments are needed for the combined features of the lower plenum flows. Missing from the typical jet experiments available are interactions with nearby circular posts and with vertical posts in the vicinity of vertical walls--with near stagnant surroundings at one extreme and significant crossflow at the other. Two types of heat transfer experiments are being considered. One addresses the ''hot channel'' problem, if

  7. Assessment of existing studies of wind loading on solar collectors

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, L. M.

    1981-02-01

    In developing solar collectors, wind loading is the major structural design consideration. Wind loading investigations have focused on establishing safe bounds for steady state loading and verifying rational but initial and conservative design approaches for the various solar collector concepts. As such, the effort has been very successful, and has contributed greatly to both the recognition and qualitative understanding of many of the physical phenomena involved. Loading coefficients corresponding to mean wind velocities have been derived in these prior studies to measure the expected structural loading on the various solar collectors. Current design and testing procedures for wind loading are discussed. The test results corresponding to numerous wind tests on heliostats, parabolic troughs, parabolic dishes, and field mounted photovoltaic arrays are discussed and the applicability of the findings across the various technologies is assessed. One of the most significant consistencies in the data from all the technologies is the apparent benefit provided by fences and field shielding. Taken in toto, these data show that load reductions of three or possibly more seem feasible, though a more thorough understanding of the phenomena involved must be attained before this benefit can be realized. It is recommended that the required understanding be developed to take advantage of this benefit and that field tests be conducted to correlate with both analyses and tests.

  8. Comparative assessment study of aboveground soft x-ray technology

    International Nuclear Information System (INIS)

    The soft x-ray regime accessible at the laboratory nominally extends from photon energies of 10 eV to 10 keV. The technology relies on capacitor-based, short-pulse energy storage devices to generate a high-energy-density plasma 1 cc in volume and lasting about 10 ns. The hot plasma is created either by conversion of short-pulse electrical energy into light ions that heat the plasma or into a magnetically-driven imploding plasma. Applications of these intense soft x-rays include evaluation of their interaction with materials, as an energy source for weapons effects, as a source for ICF experiments, and as a source for weapons physics experiments. Because of management's interest in encouraging the development of new applications to this technology, they did a year-long comparative assessment study that involved surveying scientists engaged in such research. The literature is filled with examples of benchmarking in the manufacturing and service industries; however, the authors found only one documented case where scientific research had been benchmarked. The experience in benchmarking an area of scientific research and some of the findings are described in this paper

  9. Contaminants in milk and impact of heating: An assessment study

    Directory of Open Access Journals (Sweden)

    Vandana Awasthi

    2012-01-01

    Full Text Available Background: The major contaminants usually encountered in milk and milk products include pesticide residues, heavy metals, and aflatoxin M1 (AFM1. Primarily, milk get contaminated before milching, from the cattle feed, from sources/materials used during the processing of milk as well as improper handling of the milk during the pre- and postprocessing period. Objective: The purpose of this study was to evaluate the effect of household practices on milk contaminants. Materials and Methods: Samples of pasteurized as well as unpasteurized milk (Vendor′s milk were analyzed for AFM1, pesticide residues, and heavy metals. Simulating the household practices, the impact of boiling on these contaminants was assessed. Results: The contaminant Aflatoxin M1 (AFM1 was detected at a concentration ranging from 0.071-0.075 ppb in unpasteurized as well as pasteurized milk samples analyzed during the course of study. Moreover, boiling had no impact on the quantity of AFM1 present in the milk. Pesticides and heavy metal contents were found to be within acceptable limits in all the milk samples tested. Conclusion: Mycotoxins especially aflatoxins in cattle feed and their consequential presence in milk and milk products is a serious concern world over as they are reported carcinogens. These fungal toxins are resistant to high temperatures and may lead to various health hazards. Preventive steps must be taken at each stage to ensure good quality of milk and milk products free from these contaminants. Awareness programs and education for the dairy farmers and milk processors may be helpful in this regard.

  10. FY11 Facility Assessment Study for Aeronautics Test Program

    Science.gov (United States)

    Loboda, John A.; Sydnor, George H.

    2013-01-01

    This paper presents the approach and results for the Aeronautics Test Program (ATP) FY11 Facility Assessment Project. ATP commissioned assessments in FY07 and FY11 to aid in the understanding of the current condition and reliability of its facilities and their ability to meet current and future (five year horizon) test requirements. The principle output of the assessment was a database of facility unique, prioritized investments projects with budgetary cost estimates. This database was also used to identify trends for the condition of facility systems.

  11. A Study on Public Participation in Environmental Impact Assessments

    Institute of Scientific and Technical Information of China (English)

    WangJing

    2005-01-01

    China's legislature on the environmental impact assessments contains related provisions on public participation as an important element of institutions in this field. So far, however, the stipulation remains at the level of a plain statement of principle both substantially and procedurally. The newly enacted Law on the Assessment of the Environment Impact has seen great progress in provisions for public participation if compared with similar statutes enacted in the past legislation. However, there is a gap in the procedures,

  12. Assessing Specialized Translation In Academic Contexts: A Case Study

    OpenAIRE

    Kim Grego

    2012-01-01

    This paper discusses translation assessment, first of all by briefly outlining the topic, then by restricting the reflection to specialized translation in didactic contexts and, finally, by discussing how to determine assessment criteria in one specific academic case, the ‘English specialized translation’ course of the ‘Lingue moderne per la comunicazione e la cooperazione internazionale’ Master’s programme of the University of Milan, Italy. Both generic (common to all Master’s programmes in ...

  13. Authentic tasks in higher education: Studying design principles for assessment

    OpenAIRE

    Keulen, H. van; Van den Berg, I.; Ramaekers, S.

    2006-01-01

    Students may benefit significantly from learning through authentic tasks. But how do we assess their learning outcomes, taking into account the specific characteristics of authentic tasks? In the second presentation of this symposium on design principles for authentic tasks we present and discuss principles for assessment procedures in authentic tasks from three different domains: clinical reasoning in Veterinary Science; internships in Medicine; and essay writing in History, all at Utrecht U...

  14. Continuous assessment in process engineering education – two case studies

    OpenAIRE

    Heikkinen, E.-P. (Eetu-Pekka); Jaako, J. (Juha)

    2011-01-01

    BACKGROUND. Development of higher engineering education requires under-standing on teaching, learning and assessment. The content being taught and boundary conditions, such as available resources, must be taken into consideration. In practice it is not possible to implement everything that is presented as desirable in educational research and a compromise is needed, where such a teaching, learning and assessment environment is created that is both theoretically sound and useful in practice. ...

  15. PARALLEL MODELS OF ASSESSMENT: INFANT MENTAL HEALTH AND THERAPEUTIC ASSESSMENT MODELS INTERSECT THROUGH EARLY CHILDHOOD CASE STUDIES.

    Science.gov (United States)

    Gart, Natalie; Zamora, Irina; Williams, Marian E

    2016-07-01

    Therapeutic Assessment (TA; S.E. Finn & M.E. Tonsager, 1997; J.D. Smith, 2010) is a collaborative, semistructured model that encourages self-discovery and meaning-making through the use of assessment as an intervention approach. This model shares core strategies with infant mental health assessment, including close collaboration with parents and caregivers, active participation of the family, a focus on developing new family stories and increasing parents' understanding of their child, and reducing isolation and increasing hope through the assessment process. The intersection of these two theoretical approaches is explored, using case studies of three infants/young children and their families to illustrate the application of TA to infant mental health. The case of an 18-month-old girl whose parents fear that she has bipolar disorder illustrates the core principles of the TA model, highlighting the use of assessment intervention sessions and the clinical approach to preparing assessment feedback. The second case follows an infant with a rare genetic syndrome from ages 2 to 24 months, focusing on the assessor-parent relationship and the importance of a developmental perspective. Finally, assessment of a 3-year-old boy illustrates the development and use of a fable as a tool to provide feedback to a young child about assessment findings and recommendations. PMID:27333488

  16. Summaries and Technical Documentation for Performance Changes in Citizenship and Social Studies Assessments, 1969-76.

    Science.gov (United States)

    Education Commission of the States, Denver, CO. National Assessment of Educational Progress.

    This report summarizes changes in student performance in the areas of citizenship and social studies, as measured by the National Assessment of Educational Progress. An initial assessment of citizenship was conducted in 1969-70, and an initial assessment of social studies was conducted in 1971-72. Both areas were reassessed in 1975-76. Because…

  17. A Phenomenological Case Study: Teacher Bias Effects on Early Education Assessments

    Science.gov (United States)

    Reynolds, Rebecca Jeannine

    2012-01-01

    This qualitative phenomenological case study explored the lived experiences of a purposive sample of 20 current and past early education teachers who have experience in assessing children through observational assessment. The purpose of this study was to determine if bias affects the documentation of observational assessment and the implementation…

  18. Hydrodynamic and Ecological Assessment of Nearshore Restoration: A Modeling Study

    International Nuclear Information System (INIS)

    Along the Pacific Northwest coast, much of the estuarine habitat has been diked over the last century for agricultural land use, residential and commercial development, and transportation corridors. As a result, many of the ecological processes and functions have been disrupted. To protect coastal habitats that are vital to aquatic species, many restoration projects are currently underway to restore the estuarine and coastal ecosystems through dike breaches, setbacks, and removals. Information on physical processes and hydrodynamic conditions are critical for the assessment of the success of restoration actions. Restoration of a 160- acre property at the mouth of the Stillaguamish River in Puget Sound has been proposed. The goal is to restore native tidal habitats and estuary-scale ecological processes by removing the dike. In this study, a three-dimensional hydrodynamic model was developed for the Stillaguamish River estuary to simulate estuarine processes. The model was calibrated to observed tide, current, and salinity data for existing conditions and applied to simulate the hydrodynamic responses to two restoration alternatives. Responses were evaluated at the scale of the restoration footprint. Model data was combined with biophysical data to predict habitat responses at the site. Results showed that the proposed dike removal would result in desired tidal flushing and conditions that would support four habitat types on the restoration footprint. At the estuary scale, restoration would substantially increase the proportion of area flushed with freshwater (< 5 ppt) at flood tide. Potential implications of predicted changes in salinity and flow dynamics are discussed relative to the distribution of tidal marsh habitat.

  19. 77 FR 70451 - Proposed Collection; Comment Request; Methodological Studies for the Population Assessment of...

    Science.gov (United States)

    2012-11-26

    ... Studies for the Population Assessment of Tobacco and Health (PATH) Study SUMMARY: In compliance with the... Studies for Population Assessment of Tobacco and Health (PATH) Study. Type of Information Collection Request: New. Need and Use of Information Collection: The PATH study will establish a...

  20. STUDYING OF SAFETY CLIMATE ASSESSMENT: A CASE STUDY AT STEEL INDUSTRY

    OpenAIRE

    Hassan DARVISH; Mehdi ROOSTAEI; Azizi, Saeed

    2011-01-01

    Evolution of safety climate used as a practical means has determined and assessed potential problems relevant to safety issues in an organization and can be used in individuals’ performance and work efficiency and decreasing rate of incidents ;as well as; guidance to provide safety organization policy and comparison of safety performance in different organizations. The study wants to determine and prepare safety climate profile and application of its results in improving safety situation. In ...

  1. Relations between student perceptions of assessment authenticity, study approaches and learning outcome

    NARCIS (Netherlands)

    Gulikers, J.T.M.; Bastiaens, Th.J.; Kirschner, P.A.; Kester, L.

    2006-01-01

    This article examines the relationships between perceptions of authenticity and alignment on study approach and learning outcome. Senior students of a vocational training program performed an authentic assessment and filled in a questionnaire about the authenticity of various assessment characterist

  2. Climate Change Vulnerability Assessments: Four Case Studies of Water Utility Practices (2011 Final)

    Science.gov (United States)

    EPA is releasing the final report titled, Climate Change Vulnerability Assessments: Four Case Studies of Water Utility Practices. This report was prepared by the National Center for Environmental Assessment's Global Climate Research Staff in the Office of Research and Developmen...

  3. Assessing Spatial Data Quality of Participatory GIS Studies: a Case Study in Cape Town

    Science.gov (United States)

    Musungu, K.

    2015-10-01

    Participatory GIS (PGIS) has been prescribed by scholars who sought to find a means to enable more equitable access to GIS data, diversifying the types of knowledge captured by a GIS and re-engineering GIS software. The popularity of PGIS is evident in the various studies and contexts in which it has been utilised. These include studies in risk assessment, land administration, resource management, crime mapping and urban design to mention but a few. Despite the popularity of PGIS as a body of research, little has been done in the analysis of the quality of PGIS information. The study investigated the use of data quality criteria commonly used in traditional GIS systems and shows that it is possible to apply the criteria used in traditional GIS to PGIS. It provides a starting point for PGIS studies to assess the quality of the product. Notably, this a reflective exercise on one case study, but the methodologies used in this study have been replicated in many others undertaken by Community Based Organisations as well as Non-Governmental Organisations. Therefore the findings are relevant to such projects.

  4. ASSESSING SPATIAL DATA QUALITY OF PARTICIPATORY GIS STUDIES: A CASE STUDY IN CAPE TOWN

    Directory of Open Access Journals (Sweden)

    K. Musungu

    2015-10-01

    Full Text Available Participatory GIS (PGIS has been prescribed by scholars who sought to find a means to enable more equitable access to GIS data, diversifying the types of knowledge captured by a GIS and re-engineering GIS software. The popularity of PGIS is evident in the various studies and contexts in which it has been utilised. These include studies in risk assessment, land administration, resource management, crime mapping and urban design to mention but a few. Despite the popularity of PGIS as a body of research, little has been done in the analysis of the quality of PGIS information. The study investigated the use of data quality criteria commonly used in traditional GIS systems and shows that it is possible to apply the criteria used in traditional GIS to PGIS. It provides a starting point for PGIS studies to assess the quality of the product. Notably, this a reflective exercise on one case study, but the methodologies used in this study have been replicated in many others undertaken by Community Based Organisations as well as Non-Governmental Organisations. Therefore the findings are relevant to such projects.

  5. Risky Assessments: Participant Suicidality and Distress Associated with Research Assessments in a Treatment Study of Suicidal Behavior

    Science.gov (United States)

    Reynolds, Sarah K.; Lindenboim, Noam; Comtois, Katherine Anne; Murray, Angela; Linehan, Marsha M.

    2006-01-01

    The purpose of this study was to examine patterns of self-reported suicidality and distress during research assessments in a sample of 63 women meeting criteria for borderline personality disorder and current and chronic suicidality. The risk management protocol we used during the two-year study period (University of Washington Risk Assessment…

  6. Study of Value Assessment Model of Forest Biodiversity Based on the Habitat Area in China

    Directory of Open Access Journals (Sweden)

    Ying Zhang

    2014-03-01

    Full Text Available Forest biodiversity is an important part of biodiversity. There is an essential significance of studying forest biodiversity assessment for promoting the conservation of biodiversity and enhancing biodiversity management in China. This study collected forest biodiversity habitat area, output value of forestry and so on forest biodiversity assessment-related data from 2001 to 2010 in China and using optimal control methods in cybernetics to establish value assessment model of forest biodiversity based on the data of habitat area, as well as calculated the optimal price for forest biodiversity assessment. The result showed that forest biodiversity habitat assessment of the optimal price is 9,970 RMB Yuan/ha and there is a dynamic model for forest biodiversity assessment. Finally, the study suggested that studies of forest biodiversity assessment in China, in particular, studying of valuation of forest biodiversity should consider using shadow price and the social, economic and other factors should be taken into account

  7. Assessment Study of Small Space Debris Removal by Laser Satellites

    Science.gov (United States)

    Choi, Sang H.; Papa, Richard S.

    2011-01-01

    Space debris in Earth orbit poses significant danger to satellites, humans in space, and future space exploration activities. In particular, the increasing number of unidentifiable objects, smaller than 10 cm, presents a serious hazard. Numerous technologies have been studied for removing unwanted objects in space. Our approach uses a short wavelength laser stationed in orbit to vaporize these small objects. This paper discusses the power requirements for space debris removal using lasers. A short wavelength laser pumped directly or indirectly by solar energy can scan, identify, position, and illuminate the target, which will then be vaporized or slow down the orbital speed of debris by laser detonation until it re-enters the atmosphere. The laser-induced plasma plume has a dispersive motion of approximately 105 m/sec with a Lambertian profile in the direction of the incoming beam [1-2]. The resulting fast ejecting jet plume of vaporized material should prevent matter recombination and condensation. If it allows any condensation of vaporized material, the size of condensed material will be no more than a nanoscale level [3]. Lasers for this purpose can be indirectly pumped by power from an array of solar cells or directly pumped by the solar spectrum [4]. The energy required for vaporization and ionization of a 10 cm cube ( 2700 gm) of aluminum is 87,160 kJ. To remove this amount of aluminum in 3 minutes requires a continuous laser beam power of at least 5.38 MW under the consideration of 9% laser absorption by aluminum [5] and 5% laser pumping efficiency. The power needed for pumping 5.38 MW laser is approximately 108 MW, which can be obtained from a large solar array with 40% efficiency solar cells and a minimal area of 450 meters by 450 meters. This solar array would collect approximately 108 MW. The power required for system operation and maneuvering can be obtained by increasing solar panel size. This feasibility assessment covers roughly the power requirement

  8. Examining the Implicit Relational Assessment Procedure: Four Preliminary Studies

    Science.gov (United States)

    Drake, Chad E.; Kellum, Karen Kate; Wilson, Kelly G.; Luoma, Jason B.; Weinstein, Jonathan H.; Adams, Catherine H.

    2010-01-01

    The Implicit Relational Assessment Procedure (IRAP) is a relatively new measure of implicit cognition that tests cognition as relational behavior instead of an associative activity and thus may provide a more specific measure of cognitive repertoires, including those for social biases, than better known implicit measures such as the Implicit…

  9. Risk assessment of contact allergens: a feasibility study

    NARCIS (Netherlands)

    Iersel AAJ van; LEO; LGM; LPI

    1996-01-01

    Skin sensitization, allergic contact dermatitis, is not a life-threatening condition but it can be very impairing. For that reason contemporary legislation prescribes the assessment of the skin sensitizing properties of substances like chemicals, house-hold and personel-care products. In general, sk

  10. Clinical assessment of transthoracic echocardiography skills: a generalizability study

    DEFF Research Database (Denmark)

    Nielsen, Dorte Guldbrand; O'Neill, Lotte; Jensen, Signe

    2015-01-01

    objective assessment instrument for TTE technical proficiency including a global rating score and a checklist score has previously been shown reliability and validity in a standardised setting. Objectives: As clinical test situations typically have several sources of error giving rise to variance in scores...

  11. Qualitative Assessment across Language Barriers: An Action Research Study

    Science.gov (United States)

    Cronje, Johannes C.

    2009-01-01

    If students cannot express themselves in the language of the assessor, and if the assessor is not familiar with the cultural constraints within which students operate, it is difficult for the assessor to collect evidence of adequate performance. This article describes the assessment of three digital artefacts where the assessor strove to…

  12. Cultural Shifts, Multimodal Representations, and Assessment Practices: A Case Study

    Science.gov (United States)

    Curwood, Jen Scott

    2012-01-01

    Multimodal texts involve the presence, absence, and co-occurrence of alphabetic text with visual, audio, tactile, gestural, and spatial representations. This article explores how teachers' evaluation of students' multimodal work can be understood in terms of cognition and culture. When teachers apply a paradigm of assessment rooted in print-based…

  13. Study, Examinations, and Stress: Blood Pressure Assessments in College Students

    Science.gov (United States)

    Hughes, Brian M.

    2005-01-01

    The issue of stress associated with higher education and its impact on markers of student health is explored in three experiments looking at blood pressure levels in college students. All participants were full-time undergraduate students of psychology. In Experiment 1, academic fear of failure, assessed using psychometric testing, was found to be…

  14. Quantum Mechanics Concept Assessment: Development and Validation Study

    Science.gov (United States)

    Sadaghiani, Homeyra R.; Pollock, Steven J.

    2015-01-01

    As part of an ongoing investigation of students' learning in first semester upper-division quantum mechanics, we needed a high-quality conceptual assessment instrument for comparing outcomes of different curricular approaches. The process of developing such a tool started with converting a preliminary version of a 14-item open-ended quantum…

  15. A Step-by-Step Study of Formative Assessment

    Science.gov (United States)

    Pietsch, Laura

    2013-01-01

    This article presents a guide to the development of formative assessments for school librarians participating in professional learning communities (PLC). It describes librarians' reading of assigned books, meeting with their PLCs, and incorporation of learned strategies in their daily instruction. Central library service readers' regular…

  16. 降低峰均值比的时域交织分割PTS算法及分析%Interleaved Partitioning PTS method in time domain for PAPR Reduction

    Institute of Scientific and Technical Information of China (English)

    卢光跃; 邵朝; 马长征

    2008-01-01

    本文根据交织分割部分传输序列(IPTS)的特点,利用具有周期结构的序列DFT的性质,提出基于时域的IPTS算法;同时,将其和常规PTS算法、选择映射算法(SLM)及基于时域循环卷积的PAPR降低算法(TCM)的计算量、性能等进行比较和分析.仿真实验和分析说明本文方法能降低常规IPTS算法的运算量,同时以较小的运算量达到常规相邻分割PTS(APTS)算法的性能.

  17. Comprehensive Environmental Assessment and U.S. EPA Nanomaterial Case Studies

    Science.gov (United States)

    These case studies are not completed risk assessments but are structured around an approach known as comprehensive environmental assessment (CEA), which combines a product life cycle framework with the risk assessment paradigm (Davis, J.M., J. Nanosci. Nanotech. 7:402-9, 2007). ...

  18. Validation of the CDA CAMBRA caries risk assessment--a six-year retrospective study.

    Science.gov (United States)

    Doméjean, Sophie; White, Joel M; Featherstone, John D B

    2011-10-01

    The present manuscript presents the results of a six-year retrospective study validating caries risk assessment in a caries management by risk assessment program in a large predominantly adult patient population seeking dental care. CRA was successful in accurately identifying patients at high caries risk. Caries risk assessment in a CAMBRA program is a good clinical tool for everyday dental practice. PMID:22132582

  19. General Education Assessment at Private Historically Black Colleges and Universities: An Exploratory Study

    Science.gov (United States)

    Jones, Willis A.

    2010-01-01

    The majority of research on general education assessment in recent years has focused primarily on predominately white institutions. Very little is known about general education assessment at historically black colleges and universities (HBCUS). Using descriptive analysis, this exploratory study examines the state of general education assessment at…

  20. The effect of practical experience on perceptions of assessment authenticity, study approach and learning outcome

    NARCIS (Netherlands)

    Gulikers, J.T.M.; Kester, L.; Kirschner, P.A.; Bastiaens, Th.J.

    2008-01-01

    Does authentic assessment or the perception of it affect how students study and learn? Does practical experience affect how assessment authenticity is perceived? And does practical experience influence how an authentic assessment affects student learning? Mixed methods design yielded insight into th

  1. Assessment Criteria for Competency-Based Education: A Study in Nursing Education

    Science.gov (United States)

    Fastré, Greet M. J.; van der Klink, Marcel R.; Amsing-Smit, Pauline; van Merriënboer, Jeroen J.

    2014-01-01

    This study examined the effects of type of assessment criteria (performance-based vs. competency-based), the relevance of assessment criteria (relevant criteria vs. all criteria), and their interaction on secondary vocational education students' performance and assessment skills. Students on three programmes in the domain of nursing and care…

  2. A Modeling Study about the Factors Affecting Assessment Preferences of Pre-Service Teachers

    Science.gov (United States)

    Dogan, C. Deha

    2013-01-01

    This is a correlation study which aims to assess the theoretical model about the factors affecting assessment preferences of pre-service teachers. In the model the relations among the "alternative assessment methods", "critical thinking learning strategy", "Elaboration learning strategy", "self-efficacy about…

  3. Risk Assessment of Vertical Breakwaters -- A Case Study in Turkey

    Institute of Scientific and Technical Information of China (English)

    Can Elmar BALAS; Levent KOC

    2002-01-01

    In the reliability-risk assessment, the second order reliability index (βⅡ) method and the Conditional ExpectationMonte Carlo (CEMC) simulation are interrelated as a new Level Ⅲ approach for the analysis of the safety level of theDalaman yacht harbor vertical wall breakwater in Turkey. The missing wave data of the Dalaman measurement station arehindcasted by use of muhi-layer feed-forward neural networks with the steepest descent and conjugate gradient algorithms.The structural failure probabilities of sliding and overturning failure modes are forecasted by approximation of the failure sur-face with a second-degree polynomial of an equal curvature at the design point. In the new approach, for each randomlygenerated load and tide combination, the joint failure probability reflects both the occurrence probability of loading conditionand the structural failure risk at the limit state. The approach can be applied to risk assessment of vertical breakwaters inshort CPU durations of portable computers.

  4. Protocols for conducting dolphin capture-release health assessment studies

    OpenAIRE

    Fair, Patricia A.; Jeffrey D. Adams; Zolman, Eric; McCulloch, Stephen D.; Goldstein, Juli D.; Murdoch, M. Elizabeth; Varela, Rene; Hansen, Larry; Townsend, Forrest; Kucklick, John; Bryan, Colleen; Christopher, Steven; Pugh, Rebecca; Bossart, Gregory D.

    2006-01-01

    Marine mammals, such as dolphins, can serve as key indicator species in coastal areas by reflecting the effects of natural and anthropogenic stressors. As such they are often considered sentinels of environmental and ecosystem health (Bossart 2006; Wells et al. 2004; Fair and Becker 2000). The bottlenose dolphin is an apex predator and a key component of many estuarine environments in the southeastern United States (Woodward-Clyde Consultants 1994; SCDNR 2005). Health assessments of dolphins ...

  5. A novel assessment of adolescent mobility: a pilot study

    DEFF Research Database (Denmark)

    Stewart, Tom; Duncan, Scott; Chaix, Basile;

    2015-01-01

    BACKGROUND:The accurate measurement of daily mobility and travel to destinations beyond the residential neighbourhood has been identified as an important but almost systematically overlooked factor when investigating the relationship between exposure to the built environment and physical activity......, 15.9+/-1.48years) in 2013. Participants underwent anthropometric assessment before completing a custom-designed VERITAS protocol under the supervision of trained interview technicians. Regularly visited destinations, school travel routes, transportation modes, travel companions, and perceived...

  6. Assessing monoclonal antibody product quality attribute criticality through clinical studies

    OpenAIRE

    Goetze, Andrew M; Schenauer, Matthew R; Flynn, Gregory C.

    2010-01-01

    Recombinant therapeutic proteins, including antibodies, contain a variety of chemical and physical modifications. Great effort is expended during process and formulation development in controlling and minimizing this heterogeneity, which may not affect safety or efficacy and, therefore, may not need to be controlled. Many of the chemical conversions also occur in vivo and knowledge about the alterations can be applied to assessment of the potential impact on characteristics and the biological...

  7. Cognitive Assessment System (CAS): Psychometric studies with Portuguese children.

    OpenAIRE

    Rosário, A.; Candeias, A.A.; Roazzi, A.

    2013-01-01

    The Cognitive Assessment System (CAS) is a new measure of cognitive abilities based on the Planning, Attention, Simultaneous and Successive (PASS) Theory. This theory is derived from research in neuropsychological and cognitive Psychology with particular emphasis on the work of Luria (1973). According to Naglieri (1999) and Naglieri and Das (1997), the PASS cognitive processes are the basic building blocks of human intellectual functioning. Planning processes provide cognitive control, utiliz...

  8. A novel assessment of adolescent mobility: a pilot study

    OpenAIRE

    Stewart, Tom; Duncan, Scott; Chaix, Basile; Kestens, Yan; Schipperijn, Jasper; Schofield, Grant

    2015-01-01

    Background The accurate measurement of daily mobility and travel to destinations beyond the residential neighbourhood has been identified as an important but almost systematically overlooked factor when investigating the relationship between exposure to the built environment and physical activity. The recent development of VERITAS – a web-based application nested within a computer-assisted personal interview – allows researchers to assess daily mobility, travel to regular destinations, and pe...

  9. Objectifying facial expressivity assessment of Parkinson's patients: preliminary study.

    Science.gov (United States)

    Wu, Peng; Gonzalez, Isabel; Patsis, Georgios; Jiang, Dongmei; Sahli, Hichem; Kerckhofs, Eric; Vandekerckhove, Marie

    2014-01-01

    Patients with Parkinson's disease (PD) can exhibit a reduction of spontaneous facial expression, designated as "facial masking," a symptom in which facial muscles become rigid. To improve clinical assessment of facial expressivity of PD, this work attempts to quantify the dynamic facial expressivity (facial activity) of PD by automatically recognizing facial action units (AUs) and estimating their intensity. Spontaneous facial expressivity was assessed by comparing 7 PD patients with 8 control participants. To voluntarily produce spontaneous facial expressions that resemble those typically triggered by emotions, six emotions (amusement, sadness, anger, disgust, surprise, and fear) were elicited using movie clips. During the movie clips, physiological signals (facial electromyography (EMG) and electrocardiogram (ECG)) and frontal face video of the participants were recorded. The participants were asked to report on their emotional states throughout the experiment. We first examined the effectiveness of the emotion manipulation by evaluating the participant's self-reports. Disgust-induced emotions were significantly higher than the other emotions. Thus we focused on the analysis of the recorded data during watching disgust movie clips. The proposed facial expressivity assessment approach captured differences in facial expressivity between PD patients and controls. Also differences between PD patients with different progression of Parkinson's disease have been observed. PMID:25478003

  10. Assessing Exposure to Organophosphorus Pesticides by Biomonitoring in Epidemiologic Studies of Birth Outcomes

    OpenAIRE

    Needham, Larry L.

    2005-01-01

    For epidemiologic studies that evaluate the relation between potential exposures to environmental chemicals and adverse outcomes, accurate assessments of exposures and health outcomes are needed. Three prospective cohort studies recently evaluated the relation between exposure, as assessed by biomonitoring, of pregnant women to organophosphorus pesticides and several birth outcomes. Here these three studies are compared in terms of the exposure scenarios and exposure assessments. The primary ...

  11. A Study of an Intelligent Battlefield Damage Assessment System Based on a Multi-agent System

    Institute of Scientific and Technical Information of China (English)

    LIU Xiang-kai; DAI Wan-jun; TANG Yan-feng; WANG Jia-ning

    2008-01-01

    Battlefield damage assessment is the key to Battlefield Damage Assessment and Repair (BDAR).We present an Intelligent Battlefield Damage Assessment System (IBDAS) based on multi-agent system technology. We first establish the system framework, and then study the interior structure and workflow of a problem allocation agent. The result shows that, there are many advantages to resolve the problem of battlefield damage assessment by applying multi-agent system technology, and it will bring significant military benefit.

  12. A study on assessment methodology of surveillance test interval and allowed outage time

    Energy Technology Data Exchange (ETDEWEB)

    Che, Moo Seong; Cheong, Chang Hyeon; Lee, Byeong Cheol [Seoul Nationl Univ., Seoul (Korea, Republic of)] (and others)

    1996-07-15

    The objectives of this study is the development of methodology by which assessing the optimizes Surveillance Test Interval(STI) and Allowed Outage Time(AOT) using PSA method that can supplement the current deterministic methods and the improvement of Korea nuclear power plants safety. In the first year of this study, the survey about the assessment methodologies, modeling and results performed by domestic and international researches is performed as the basic step before developing the assessment methodology of this study. The assessment methodology that supplement the revealed problems in many other studies is presented and the application of new methodology into the example system assures the feasibility of this method.

  13. Limitations of lifetime alcohol use disorder assessments: A criterion-validation study.

    Science.gov (United States)

    Haeny, Angela M; Littlefield, Andrew K; Sher, Kenneth J

    2016-08-01

    The goal of the present study was to compare etiologically and clinically relevant correlates of lifetime AUD (e.g., alcohol consumption, personality traits, psychiatric disorders) based on a single assessment compared to a cumulative, prospective assessment of lifetime AUD. Data were drawn from the Alcohol, Health and Behavior (AHB; baseline N=489) study, which consisted of a prospective cohort of college students assessed seven times over a 16-year period ([M(SD) age at baseline=18.56 (.97)] and [M(SD) age at final assessment=34.33 (.82)]). The participants were assessed using the Diagnostic Interview Schedule (DIS) for DSM-III at Waves 1-7 and for DSM-IV at Waves 6-7. A single assessment and cumulative assessments of DSM-III lifetime AUD at Wave 6 (M[SD] age=28.98 [1.03]) were used to predict past-year alcohol related variables (e.g., alcohol consumption, drinking motives, drinking expectancies), personality variables, general functioning, lifetime substance use, and lifetime psychiatric disorders at Wave 7. Significantly larger correlations were found between the cumulative assessment and eight of the 25 etiologically relevant correlates of AUD compared to the single assessment. Further, significant incremental validity of cumulative assessment over single, retrospective assessment was observed for 16 of the 25 covariates. Overall, this study provides further support for the value of using prospective data with multiple assessments when determining lifetime history of disorder. PMID:27082748

  14. Tissue quality assessment using a novel direct elasticity assessment device (the E-finger: a cadaveric study of prostatectomy dissection.

    Directory of Open Access Journals (Sweden)

    Daniel W Good

    Full Text Available Minimally invasive radical prostatectomy (RP (robotic and laparoscopic, have brought improvements in the outcomes of RP due to improved views and increased degrees of freedom of surgical devices. Robotic and laparoscopic surgeries do not incorporate haptic feedback, which may result in complications secondary to inadequate tissue dissection (causing positive surgical margins, rhabdosphincter damage, etc. We developed a micro-engineered device (6 mm2 sized [E-finger] capable of quantitative elasticity assessment, with amplitude ratio, mean ratio and phase lag representing this. The aim was to assess the utility of the device in differentiating peri-prostatic tissue types in order to guide prostate dissection.Two embalmed and 2 fresh frozen cadavers were used in the study. Baseline elasticity values were assessed in bladder, prostate and rhabdosphincter of pre-dissected embalmed cadavers using the micro-engineered device. A measurement grid was created to span from the bladder, across the prostate and onto the rhabdosphincter of fresh frozen cadavers to enable a systematic quantitative elasticity assessment of the entire area by 2 independent assessors. Tissue was sectioned along each row of elasticity measurement points, and stained with haematoxylin and eosin (H&E. Image analysis was performed with Image Pro Premier to determine the histology at each measurement point.Statistically significant differences in elasticity were identified between bladder, prostate and sphincter in both embalmed and fresh frozen cadavers (p = < 0.001. Intra-class correlation (ICC reliability tests showed good reliability (average ICC = 0.851. Sensitivity and specificity for tissue identification was 77% and 70% respectively to a resolution of 6 mm2.This cadaveric study has evaluated the ability of our elasticity assessment device to differentiate bladder, prostate and rhabdosphincter to a resolution of 6 mm2. The results provide useful data for which to continue to

  15. Site-Specific ecological risk assessment. Case-study 2

    DEFF Research Database (Denmark)

    Jensen, John

    The decision supporting and integrating assessment tool, TRIAD, is used site-specific on PAH- and heavy metal contaminated sites in Denmark. The various aspects of the TRIAD approach are used on a set of chemistry-, ecotoxicology- and ecology related data collected among others in the EU project...... “Development of a decision support system for sustainable management of contaminated land by linking bioavailability, ecological risk and ground water pollution of organic pollutants”or in short “LIBERATION”. The presentation includes examples on how to scale and integrate the results from various scientific...

  16. The study of the life cycle of technology assessment model

    Institute of Scientific and Technical Information of China (English)

    SHEN Yu-Zhi; HUANG Xun-jiang

    2001-01-01

    The life cycle of technology is one of the most important indexes to weigh up the risk of the investment to neo-tech. There are so many uncertainties because it is conditioned by a lot of factors, we can not make a rational forecasting by traditional assessment method. So this paper gives a conprehensive consideration to the factors that influence production and makes some modification to production function, and establishes the life cycle of technology assessmet model by the method of fuzzy mathematics. So it quantifies the risk of investment. We can take it as one foundational index for the decision making of the investment.

  17. Do you feel the difference? – A motion assessment study

    OpenAIRE

    Brünger-Koch, Martin; Briest, Susanne; Vollrath, Mark

    2006-01-01

    Since June 2005, a new moving-base driving Simulator (6 DoF) is in operation at the DLR Institute of Transportation Systems. Initial experiments were conducted in order to evaluate the participant’s ability to control a car within a virtual environment with different motion platform characteristics. In addition, the subjects assessed the quality of the perceived motion. The driving behaviour in the simulator was compared to driving in the real world with an equipped car (the DLR ViewCar). ...

  18. Integrating risk assessment and life cycle assessment: a case study of insulation.

    Science.gov (United States)

    Nishioka, Yurika; Levy, Jonathan I; Norris, Gregory A; Wilson, Andrew; Hofstetter, Patrick; Spengler, John D

    2002-10-01

    Increasing residential insulation can decrease energy consumption and provide public health benefits, given changes in emissions from fuel combustion, but also has cost implications and ancillary risks and benefits. Risk assessment or life cycle assessment can be used to calculate the net impacts and determine whether more stringent energy codes or other conservation policies would be warranted, but few analyses have combined the critical elements of both methodologies In this article, we present the first portion of a combined analysis, with the goal of estimating the net public health impacts of increasing residential insulation for new housing from current practice to the latest International Energy Conservation Code (IECC 2000). We model state-by-state residential energy savings and evaluate particulate matter less than 2.5 microm in diameter (PM2.5), NOx, and SO2 emission reductions. We use past dispersion modeling results to estimate reductions in exposure, and we apply concentration-response functions for premature mortality and selected morbidity outcomes using current epidemiological knowledge of effects of PM2.5 (primary and secondary). We find that an insulation policy shift would save 3 x 10(14) British thermal units or BTU (3 x 10(17) J) over a 10-year period, resulting in reduced emissions of 1,000 tons of PM2.5, 30,000 tons of NOx, and 40,000 tons of SO2. These emission reductions yield an estimated 60 fewer fatalities during this period, with the geographic distribution of health benefits differing from the distribution of energy savings because of differences in energy sources, population patterns, and meteorology. We discuss the methodology to be used to integrate life cycle calculations, which can ultimately yield estimates that can be compared with costs to determine the influence of external costs on benefit-cost calculations. PMID:12442994

  19. In vivo assessment of dopamine and serotonin receptors measured by C-11 n-methylspiperone (NMSP) in patients with schizophrenia

    International Nuclear Information System (INIS)

    The authors carried out PET imaging with C-11 NMSP in 13 pts. diagnosed as chronic schizophrenic by (DSM 3) criteria. They had no detectable serum neuroleptics by radioassay at the time of the scan. No pt. had received a neuroleptic for at least 1 week before study, with an avg. abstinence of 7 mo. One had never been on neuroleptics. During the time of scanning, 8/13 had delusions and hallucinations. There was no statistically significant difference from 44 age and sex matched control subjects for the 43 min. Caudate/cerebellar ratio, or the Frontal/Cerebellar ratio, both measures of relative dopamine D2, and serotonin S2 binding. These preliminary studies suggest that these drug free pts. show no large differences in the receptor levels compared to normal data. Differences from in vitro data could be due to: differences in duration of illness (the avg. 10.3) yrs.; difference in age (our pts. vg. 32.7 are much younger than those dying with schizophrenia); drug induced effects at death or persistent neuroleptic effect in our pts.; or difference in method

  20. Assessment of polymorphic metabolite data in bioavailability/bioequivalence studies - considerations and challenges

    Directory of Open Access Journals (Sweden)

    Nuggehally R Srinivas

    2011-01-01

    Full Text Available Bioavailability (BA/ bioequivalence (BE studies are the cornerstone for the approval of generic drugs. While BA/BE assessment involving the pharmacokinetic data of the parent compound has been routinely performed, the introduction of the assessment of metabolite(s data, alone or in addition to parent compound, has also emerged. In this context, the assessment of BA/BE of metabolite(s may pose additional complexities and challenges, if the metabolic pathway is under the influence of a polymorphic enzyme. This communication provides brief perspectives on the challenges and study design considerations for the assessment of polymorphic metabolite in BA/BE studies.

  1. 1982 Aleutian Islands salmon stock assessment study: Legislative report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes a comprehensive research study of the Aleutian Islands salmon resources in 1982. The study encompassed the area west of Unimak Pass to Attu...

  2. Study of Value Assessment Model of Forest Biodiversity Based on the Habitat Area in China

    OpenAIRE

    Ying Zhang; Hui Li; Ye Feng

    2014-01-01

    Forest biodiversity is an important part of biodiversity. There is an essential significance of studying forest biodiversity assessment for promoting the conservation of biodiversity and enhancing biodiversity management in China. This study collected forest biodiversity habitat area, output value of forestry and so on forest biodiversity assessment-related data from 2001 to 2010 in China and using optimal control methods in cybernetics to establish value assessment model of forest biodiversi...

  3. Review of pressurized thermal shock studies of large scale reactor pressure vessels in Hungary

    Directory of Open Access Journals (Sweden)

    Tamás Fekete

    2016-03-01

    Full Text Available In Hungary, four nuclear power units were constructed more than 30 years ago; they are operating to this day. In every unit, VVER-440 V213-type light-water cooled, light-water moderated, ressurized water reactors are in operation. Since the mid-1980s, numerous researches in the field of Pressurized Thermal Shock (PTS analyses of Reactor Pressure Vessels (RPVs have been conducted in Hungary; in all of them, the concept of structural integrity was the basis of research and development. During this time, four large PTS studies with industrial relevance have been completed in Hungary. Each used different objectives and guides, and the analysis methodology was also changing. This paper gives a comparative review of the methodologies used in these large PTS Structural Integrity Analysis projects, presenting the latest results as well

  4. A Study on the Correlation between Second Language Learning Motiva-tion and Formative Assessment

    Institute of Scientific and Technical Information of China (English)

    何爱玲; 杨坚

    2014-01-01

    This paper explores the relationship between motivation and assessment and find out the assessment strategies which could motivate students better in L2 learning based on the data and responses collected from 30 non-English majors in a regional university. The data and responses revealed that formative assessment could motivate students better, especially during the process of English learning. It also revealed some problems existing in the assessment strategies implemented in this study, such as the im-partiality of peer-assessment and the poor efficiency of group work.

  5. Assessing Medication Effects in the MTA Study Using Neuropsychological Outcomes

    Science.gov (United States)

    Epstein, Jeffery N.; Conners, C. Keith; Hervey, Aaron S.; Tonev, Simon T.; Arnold, L. Eugene; Abikoff, Howard B.; Elliott, Glen; Greenhill, Laurence L.; Hechtman, Lily; Hoagwood, Kimberly; Hinshaw, Stephen P.; Hoza, Betsy; Jensen, Peter S.; March, John S.; Newcorn, Jeffrey H.; Pelham, William E.; Severe, Joanne B.; Swanson, James M.; Wells, Karen; Vitiello, Benedetto; Wigal, Timothy

    2006-01-01

    Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal…

  6. Relations between student perceptions of assessment authenticity, study approaches and learning outcome.

    NARCIS (Netherlands)

    Gulikers, Judith; Bastiaens, Theo; Kirschner, Paul A.; Kester, Liesbeth

    2008-01-01

    Gulikers, J. T. M., Bastiaens, Th. J., Kirschner, P. A., & Kester, L. (2006). Relations between student perceptions of assessment authenticity, study approaches and learning outcome. Studies in Educational Evaluation, 32 , 381-400

  7. Accuracy of deconvolution algorithms assessed by simulation studies: concise communication

    International Nuclear Information System (INIS)

    Deconvolution has been used to correct first-pass radionuclide angiocardiography for the time course of the delivery of radiopharmaceutical into the cardiopulmonary system. The extreme sensitivity of deconvolution to random errors in the data may account for some of the problems encountered in practice. We implemented several deconvolution algorithms that were suitable for use with the unimodal and multimodal superior vena caval and pulmonary curves found in left-to-right shunt quantification. The sensitivity of the algorithms to random errors was assessed using mathematical test problems degraded with pseudorandom noise. An algorithm that constrained the deconvolved pulmonary curve to be expressable as the non-negative sum of a set of lagged normal curves was found to have the smallest maximum error on the curves tested. Comparison with results from a previously published test problem indicated an error reduction of greater than 50% over previously used algorithms. Use of this algorithm may permit more accurate deconvolution of pulmonary time-activity curves and thereby improve shunt quantification

  8. 2002 progress report and public health assessment study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-10-01

    Clean Air Hamilton focuses on improving air quality in the City by providing advice to City Council. The actions and activities of Clean Air Hamilton directly benefit residents. The activities relate to natural areas and corridors; reducing and managing waste; consuming less energy; changing our modes of transportation; land use issues in urban areas; and, personal health and well-being. The report includes an assessment of human health impacts caused by air pollution in Hamilton. It uses the most recent science and Hamilton air quality data as a basis. The results indicate that approximately 100 people die prematurely each year in Hamilton, while approximately 620 people require admission to hospitals for respiratory and cardiovascular problems related to exposure to pollutants. The second Upwind Downwind Conference was held in February 2002, sponsored by Clean Air Hamilton. All three levels of government view Clean Air Hamilton as a success. The City of Hamilton was awarded the prestigious 2000 Dubai International Award for Best Practices in Improving Living Environment as a result of Clean Air Hamilton's community process in local air quality improvement. 47 refs., tabs., 1 fig.

  9. Case study of ecological risk assessment at an Alaska airport

    International Nuclear Information System (INIS)

    An ecological risk assessment was conducted for 10 sites at a remote location that has unique biological resources. Chemicals of concern included petroleum, metals, polychlorinated biphenyls, and dioxins and furans. Risks to 23 species of mammals and birds were evaluated by using toxicity reference values and a hazard quotient approach analogous to the US Environmental Protection Agency's (USEPA's) approach for evaluating noncarcinogenic human health effects. Risks to fish and aquatic invertebrates were evaluated using risk-based concentrations for water analogous to the USEPA's water quality criteria. Risks to plants were evaluated using risk-based concentrations for soil. Toxicity reference values and risk-based concentrations were developed by applying uncertainty factors to the highest quality toxicity data available in the literature. Intake rates for wildlife were obtained from the USEPA's wildlife exposure factors handbook, or were estimated using allometric equations. The sizes of wildlife home ranges were compared with the size of each site to determine species- and site-specific exposure frequencies. Indicator chemicals were selected to represent the chemical and toxicological characteristics of petroleum fractions. The species most often at risk were found to be fish and aquatic invertebrates, as well as small-bodied, ground-dwelling or ground-feeding wildlife

  10. US country studies program: Support for climate change studies, national plans, and technology assessments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This paper describes the objectives of the next phase of the U.S. Country Studies Program which was launched in support of the Framework Convention on Climate Change (FCCC). The next phases of this program aim to: assist countries in preparing Climate Change Action plans; support technology assessments and development of technology initiatives; enhance exchange of information and expertise in support of FCCC. The program offers support for these processes in the form of handbooks which have been published to aid in preparing action plans, and to provide information on methane, forestry, and energy technologies. In addition an array of training workshops have been and are scheduled to offer hands on instruction to participants, expert advice is available from trained personnel, and modeling tools are available to aid in development of action plans.

  11. Assessment of human decision reliability - a case study

    International Nuclear Information System (INIS)

    In his discussion of this case study, the author indicates that human beings are not merely machines who use rules. Thus, more focus needs to be put on studying decision making situations and their contexts. Decision theory (both normative and descriptive) and contextual psychological approaches may offer tools to cope with operator decision making. Further an ideal decision space needs to be defined for operators. The case study specifically addressed a loss of feedwater scenario and the various operator decisions that were involved in that scenario. It was concluded from this particular study that there are significant differences in the crew decision behaviours that are not explained by process variables. Through use of evidence from simulator tests with expert judgement, an approach to estimate probabilities has been developed. The modelling approach presented in this discussion is an extension of current HRA paradigms, but a natural one since all human beings make decisions

  12. A social work study for assessment of entrepreneurs' personal characteristics

    Directory of Open Access Journals (Sweden)

    Ahmad Ahmadkhani

    2012-01-01

    Full Text Available The personality of an entrepreneur plays an important role on the success of creating new ideas. There are different characteristics such as courage, hardness, braveness, which could help an entrepreneur reach his/her goals. In this paper, we present an empirical study to learn more about students who are supposed to act as entrepreneur to create jobs in different fields of accounting, computer science, mechanical engineering, etc. In this paper, There are seven aspects of accepting reasonable risk, locus of control, the need for success, mental health conditions, being pragmatic, tolerating ambiguity, dreaming and the sense of challenging in our study to measure the level of entrepreneurship. We implement ANOVA test to measure different entrepreneurship characteristics of students who study in various educational fields. The case study is associated with Sama private university located in city of Zanjan/Iran. The results indicate that there are not meaningful differences among pairwise comparison of many engineering fields.

  13. A comparative study of objective and subjective assessment of occupational risk.

    Science.gov (United States)

    Koradecka, Danuta; Pośniak, Małgorzata; Widerszal-Bazyl, Maria; Augusty Nska, Danuta; Radkiewicz, Piotr

    2010-01-01

    Measurement of dangerous, harmful and annoying factors in the working environment are used to assess occupational risk. Surveys on workers' subjective perception of risk are used, too. This study aimed to compare subjective assessment of work-related factors with their objective measurements and a national database on occupational risk. Spearman's correlation analysis, stepwise regression analysis and structural modelling were used to determine the relationship between subjective and objective risk assessment and to acquire knowledge about the role of psychosocial job characteristics as predictors of subjective assessment. Subjective assessment of hazards was related not only to their objective measurements but also to psychosocial job characteristics, workers' individual characteristics and work load. Even though subjective and objective assessments of hazard are strongly related, they are distinct phenomena. Hence, risk assessment should be carried out with both objective and subjective methods. PMID:20331915

  14. Case Study: Visual Analytics in Software Product Assessments

    OpenAIRE

    Telea, Alexandru; Voinea, Lucian; Lanza, M.; Storey, M.; Muller, H

    2009-01-01

    We present how a combination of static source code analysis, repository analysis, and visualization techniques has been used to effectively get and communicate insight in the development and project management problems of a large industrial code base. This study is an example of how visual analytics can be effectively applied to answer maintenance questions and support decision making in the software industry. We comment on the relevant findings during the study both in terms of used techniqu...

  15. Improving Biomarker Development and Assessment: Standards for Study Design

    Institute of Scientific and Technical Information of China (English)

    Ziding FENG

    2009-01-01

    Background: The Early Detection Research Network (EDRN), NCI funded and investigator driven, has the mission to evaluate biomarkers for their clinical utilities in cancer risk prediction, diagnosis, early detection, and prognosis. Abundant cancer biomarkers reported in literature yet few are used in clinics. Therefore, the emphasis of the EDRN is biomarker validation. Although schema for a phased approach to development exists and guidelines are available for study reporting, a coherent and comprehensive set of guideline for a definitive biomarker validation study design have not been delineated.Methods: We proposed PROBE study design, Prospective specimen collec-tion and Retrospective Blinded Evaluation, for pivotal definitive evaluation of the accuracy of a classification biomarker. A detailed formulation of all aspects of the design is provided. Four tables itemize aspects that relate to (i) the Clinical Context; (ii) Performance Criteria; (iii) the Biomarker test; and (iv) Study power and termination. Alternative designs and strategies were contrasted to illustrate the merit of PROBE design.Results: The ideas are applied to studies of biomarkers the intended use of which is for disease diagnosis, screening, or prognosis. Two EDRN valida-tion studies (breast cancer and prostate cancer) were used as examples to elucidate PROBE design.Conclusion: Common biases that pervade the biomarker research literaturewould be eliminated if these rigorous standards were followed closely. We urge the adoption of the design as standard of practice for pivotal evaluation of the classification accuracy ofbiomarkers.

  16. Assessing CSR and Applying Social Life Cycle Assessment: A case study on Biochemical Oxygen Demand Online Monitor

    OpenAIRE

    Wan, He

    2012-01-01

    Wuhan China and Borlänge Sweden collaborate to promote sustainable business growths. This thesis, being part of sustainable business project, aims to understand how business can contribute to sustainable development and explore mechanisms of social life cycle assessment. In an effort to answer research questions and further to achieve the general purpose, a BOD online monitor case study is described and analyzed by applying both qualitative and quantitative approaches. Data collection is base...

  17. Geothermal reservoir assessment case study: Northern Dixie Valley, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Denton, J.M.; Bell, E.J.; Jodry, R.L.

    1980-11-01

    Two 1500 foot temperature gradient holes and two deep exploratory wells were drilled and tested. Hydrologic-hydrochemical, shallow temperature survey, structural-tectonic, petrologic alteration, and solid-sample geochemistry studies were completed. Eighteen miles of high resolution reflection seismic data were gathered over the area. The study indicates that a geothermal regime with temperatures greater than 400/sup 0/F may exist at a depth of approximately 7500' to 10,000' over an area more than ten miles in length.

  18. Tissue Quality Assessment Using a Novel Direct Elasticity Assessment Device (The E-Finger): A Cadaveric Study of Prostatectomy Dissection

    Science.gov (United States)

    Good, Daniel W.; Khan, Ashfaq; Hammer, Steven; Scanlan, Paul; Shu, Wenmiao; Phipps, Simon; Parson, Simon H.; Stewart, Grant D.; Reuben, Robert; McNeill, S. Alan

    2014-01-01

    Introduction Minimally invasive radical prostatectomy (RP) (robotic and laparoscopic), have brought improvements in the outcomes of RP due to improved views and increased degrees of freedom of surgical devices. Robotic and laparoscopic surgeries do not incorporate haptic feedback, which may result in complications secondary to inadequate tissue dissection (causing positive surgical margins, rhabdosphincter damage, etc). We developed a micro-engineered device (6 mm2 sized) [E-finger]) capable of quantitative elasticity assessment, with amplitude ratio, mean ratio and phase lag representing this. The aim was to assess the utility of the device in differentiating peri-prostatic tissue types in order to guide prostate dissection. Material and Methods Two embalmed and 2 fresh frozen cadavers were used in the study. Baseline elasticity values were assessed in bladder, prostate and rhabdosphincter of pre-dissected embalmed cadavers using the micro-engineered device. A measurement grid was created to span from the bladder, across the prostate and onto the rhabdosphincter of fresh frozen cadavers to enable a systematic quantitative elasticity assessment of the entire area by 2 independent assessors. Tissue was sectioned along each row of elasticity measurement points, and stained with haematoxylin and eosin (H&E). Image analysis was performed with Image Pro Premier to determine the histology at each measurement point. Results Statistically significant differences in elasticity were identified between bladder, prostate and sphincter in both embalmed and fresh frozen cadavers (p = <0.001). Intra-class correlation (ICC) reliability tests showed good reliability (average ICC = 0.851). Sensitivity and specificity for tissue identification was 77% and 70% respectively to a resolution of 6 mm2. Conclusions This cadaveric study has evaluated the ability of our elasticity assessment device to differentiate bladder, prostate and rhabdosphincter to a resolution of 6 mm2. The

  19. An approach for integrating toxicogenomic data in risk assessment: The dibutyl phthalate case study

    International Nuclear Information System (INIS)

    An approach for evaluating and integrating genomic data in chemical risk assessment was developed based on the lessons learned from performing a case study for the chemical dibutyl phthalate. A case study prototype approach was first developed in accordance with EPA guidance and recommendations of the scientific community. Dibutyl phthalate (DBP) was selected for the case study exercise. The scoping phase of the dibutyl phthalate case study was conducted by considering the available DBP genomic data, taken together with the entire data set, for whether they could inform various risk assessment aspects, such as toxicodynamics, toxicokinetics, and dose–response. A description of weighing the available dibutyl phthalate data set for utility in risk assessment provides an example for considering genomic data for future chemical assessments. As a result of conducting the scoping process, two questions—Do the DBP toxicogenomic data inform 1) the mechanisms or modes of action?, and 2) the interspecies differences in toxicodynamics?—were selected to focus the case study exercise. Principles of the general approach include considering the genomics data in conjunction with all other data to determine their ability to inform the various qualitative and/or quantitative aspects of risk assessment, and evaluating the relationship between the available genomic and toxicity outcome data with respect to study comparability and phenotypic anchoring. Based on experience from the DBP case study, recommendations and a general approach for integrating genomic data in chemical assessment were developed to advance the broader effort to utilize 21st century data in risk assessment. - Highlights: • Performed DBP case study for integrating genomic data in risk assessment • Present approach for considering genomic data in chemical risk assessment • Present recommendations for use of genomic data in chemical risk assessment

  20. An approach for integrating toxicogenomic data in risk assessment: The dibutyl phthalate case study

    Energy Technology Data Exchange (ETDEWEB)

    Euling, Susan Y., E-mail: euling.susan@epa.gov [National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC (United States); Thompson, Chad M. [ToxStrategies, Inc., 23501 Cinco Ranch Blvd., Suite G265, Katy, TX 77494 (United States); Chiu, Weihsueh A. [National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC (United States); Benson, Robert [U.S. Environmental Protection Agency, Region 8, Mail code 8P-W, 1595 Wynkoop Street, Denver, CO 80202 (United States)

    2013-09-15

    An approach for evaluating and integrating genomic data in chemical risk assessment was developed based on the lessons learned from performing a case study for the chemical dibutyl phthalate. A case study prototype approach was first developed in accordance with EPA guidance and recommendations of the scientific community. Dibutyl phthalate (DBP) was selected for the case study exercise. The scoping phase of the dibutyl phthalate case study was conducted by considering the available DBP genomic data, taken together with the entire data set, for whether they could inform various risk assessment aspects, such as toxicodynamics, toxicokinetics, and dose–response. A description of weighing the available dibutyl phthalate data set for utility in risk assessment provides an example for considering genomic data for future chemical assessments. As a result of conducting the scoping process, two questions—Do the DBP toxicogenomic data inform 1) the mechanisms or modes of action?, and 2) the interspecies differences in toxicodynamics?—were selected to focus the case study exercise. Principles of the general approach include considering the genomics data in conjunction with all other data to determine their ability to inform the various qualitative and/or quantitative aspects of risk assessment, and evaluating the relationship between the available genomic and toxicity outcome data with respect to study comparability and phenotypic anchoring. Based on experience from the DBP case study, recommendations and a general approach for integrating genomic data in chemical assessment were developed to advance the broader effort to utilize 21st century data in risk assessment. - Highlights: • Performed DBP case study for integrating genomic data in risk assessment • Present approach for considering genomic data in chemical risk assessment • Present recommendations for use of genomic data in chemical risk assessment.

  1. Teachers’ Beliefs about Young EFL Learners’ Self-assessment: a Case Study of Macedonia

    Directory of Open Access Journals (Sweden)

    /Anžela Nikolovska

    2015-11-01

    Full Text Available The paper explores Macedonian primary EFL teachers’ attitudes, beliefs and practices regarding self-assessment of young learners (10-12 year-olds. The study surveyed primary EFL teachers (n=30 who teach English to 5th and 6th graders. The results indicated that vocabulary, grammar and reading were more often the focus of self-assessment tasks than the other areas of language learning. This, along with the finding that the receptive language skills were more frequently self-assessed than the productive skills has been attributed to the impact of the external exam. The most frequently used self-assessment techniques were can-do statements and check-lists. The perceived benefits and challenges of self-assessment have been found to be compatible with the findings of other studies. In spite of their positive attitudes towards learner self-assessment, the teachers expressed awareness of certain problems underlying its implementation as well as uncertainty about how to train learners to self-assess. In line with the conclusions, recommendations have been made regarding the need for greater emphasis on self-assessment of the neglected language areas (speaking and writing, the necessity of using a variety of self-assessment formats and the need for learner training in self-assessment from an early age.

  2. Deliberate self harm assessment by accident and emergency staff--an intervention study.

    OpenAIRE

    Crawford, M J; Turnbull, G; Wessely, S

    1998-01-01

    OBJECTIVE: To examine the impact of specific training for accident and emergency (A&E) staff on the quality of psychosocial assessment of deliberate self harm patients. METHODS: A non-randomised intervention study that compared the psychosocial assessment of deliberate self harm patients before and after a one hour teaching session for the A&E departments nursing and junior medical staff. Adequacy of psychosocial assessment was judged by examining A&E case notes. The records of the hospital's...

  3. The study of target damage assessment system based on image change detection

    Science.gov (United States)

    Zhao, Ping; Yang, Fan; Feng, Xinxi

    2009-10-01

    Target Damage Assessment (TDA) system is an important component of the intelligent command and control system. The method of building TDA based on Image Change Detection can greatly improve the system efficiency and accuracy, thus get a fast and precise assessment results. This paper firstly analyzes the structure of TDA system. Then studies the key technology in this system. Finally, gives an evaluation criteria based on image change detection of the target damage assessment system.

  4. Assessing Landscape Ecological Risk in a Mining City: A Case Study in Liaoyuan City, China

    OpenAIRE

    Jian Peng; Minli Zong; Yi'na Hu; Yanxu Liu; Jiansheng Wu

    2015-01-01

    Landscape ecological risk assessment can effectively identify key elements for landscape sustainability, which directly improves human wellbeing. However, previous research has tended to apply risk probability, measured by overlaying landscape metrics to evaluate risk, generally lacking a quantitative assessment of loss and uncertainty of risk. This study, taking Liaoyuan City as a case area, explores landscape ecological risk assessment associated with mining cities, based on probability of ...

  5. Assessment of polymorphic metabolite data in bioavailability/bioequivalence studies - considerations and challenges

    OpenAIRE

    Nuggehally R Srinivas

    2011-01-01

    Bioavailability (BA)/ bioequivalence (BE) studies are the cornerstone for the approval of generic drugs. While BA/BE assessment involving the pharmacokinetic data of the parent compound has been routinely performed, the introduction of the assessment of metabolite(s) data, alone or in addition to parent compound, has also emerged. In this context, the assessment of BA/BE of metabolite(s) may pose additional complexities and challenges, if the metabolic pathway is under the influence of a poly...

  6. Study on Environmental Impact Assessment of Technological Transformation Project of X Corporation

    OpenAIRE

    Dianwei Qi; Xin Zhang

    2013-01-01

    China is the world first country to produce cement. It is necessary for concrete construction project to implement environmental impact assessment according to national legal requirements. Applying the theory of the environmental impact assessment and environmental impact laws and regulations ,based on engineering analysis and environmental status investigation and evaluation, the paper studies on environmental impact assessment about technological transformation project of X Corporation and ...

  7. Critical Analysis of Assessment Studies of the Animal Ethics Review Process †

    OpenAIRE

    Orsolya Varga

    2013-01-01

    Simple Summary In many countries, the approval of animal research projects depends on the decisions of the ethics committees which review the projects. Since the efficiency of the protection of experimental animals greatly depends on the performance of the ethics committees, its regular assessment is crucial. This paper reviews the results of studies assessing the performance of the ethics committees, and emphasizes the importance of outcome assessment in the evaluation of the performance of ...

  8. Interrogating the Generalizability of Portfolio Assessments of Beginning Teachers: A Qualitative Study

    OpenAIRE

    Pamela A. Moss; LeeAnn M. Sutherland; Laura Haniford; Renee Miller; David Johnson; Pamela K. Geist; Stephen M. Koziol; Star, Jon R; Raymond L. Pecheone

    2004-01-01

    This qualitative study is intended to illuminate factors that affect the generalizability of portfolio assessments of beginning teachers. By generalizability, we refer here to the extent to which the portfolio assessment supports generalizations from the particular evidence reflected in the portfolio to the conception of competent teaching reflected in the standards on which the assessment is based. Or, more practically, “The key question is, ‘How likely is it that this finding would be rever...

  9. Supporting learning autonomy and curriculum coverage in university teaching: three case studies of formative assessment

    OpenAIRE

    Oprandi, Paolo Roberto

    2014-01-01

    This research investigates formative assessment at a UK research-intensive university, considering the aims and effects of their deployment. The research spans three academic disciplines broadly within the sciences and considers the influence of their history and culture on the approaches taken. It reports on three case studies originally chosen because of their innovative use of technology in teaching and assessment methods. Each case included mid-term summative assessment...

  10. Case Study : Visual Analytics in Software Product Assessments

    NARCIS (Netherlands)

    Telea, Alexandru; Voinea, Lucian; Lanza, M; Storey, M; Muller, H

    2009-01-01

    We present how a combination of static source code analysis, repository analysis, and visualization techniques has been used to effectively get and communicate insight in the development and project management problems of a large industrial code base. This study is an example of how visual analytics

  11. Preliminary Systems Design Study assessment report. Volume 8, Appendixes

    Energy Technology Data Exchange (ETDEWEB)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex`s Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume of the Systems Design Study contain four Appendixes that were part of the study. Appendix A is an EG&G Idaho, Inc., report that represents a review and compilation of previous reports describing the wastes and quantities disposed in the Subsurface Disposal Area of the Idaho National Engineering Laboratory. Appendix B contains the process flowsheets considered in this study, but not selected for detailed analysis. Appendix C is a historical tabulation of radioactive waste incinerators. Appendix D lists Department of Energy facilities where cementation stabilization systems have been used.

  12. Objective Measurements in Assessing a Black Music Course of Study.

    Science.gov (United States)

    Taylor, Frederick J.

    1990-01-01

    A study of 80 eighth grade students investigated whether incorporation of a African-American music program would have special benefits for African-American students, music-experienced students, or high-musical-ability students. African-American students, taught material consistent with their heritage, performed better than whites. It is concluded…

  13. Assessing Statistical Change Indices in Selected Social Work Intervention Research Studies

    Science.gov (United States)

    Ham, Amanda D.; Huggins-Hoyt, Kimberly Y.; Pettus, Joelle

    2016-01-01

    Objectives: This study examined how evaluation and intervention research (IR) studies assessed statistical change to ascertain effectiveness. Methods: Studies from six core social work journals (2009-2013) were reviewed (N = 1,380). Fifty-two evaluation (n= 27) and intervention (n = 25) studies met the inclusion criteria. These studies were…

  14. Teacher Factors and Perceived Assessment Practices Needs of Social Studies Teachers in Cross River State, Nigeria

    Science.gov (United States)

    Ekuri, Emmanuel Etta; Egbai, Julius Michael; Ita, Caroline Iserome

    2011-01-01

    This study evaluated perceived assessment practices needs among social studies teachers in Cross River State, Nigeria, in relation to some teacher factors (attitude towards social studies, sex, teaching experience and educational qualification). Subjects who participated in this study were 297 social studies teachers (144 males and 153 females)…

  15. MRI tracheomalacia (TM) assessment in pediatric patients: feasibility study

    DEFF Research Database (Denmark)

    Ciet, P.; Wielopolski, P.; Lever, S.;

    2011-01-01

    Purpose: TM is an excessive narrowing of the intrathoracic part of the trachea. TM is a common congenital pediatric anomaly, but it’s often not recognized due to its unspecific clinical presentation. The aims of our study are: 1) to develop cine-MRI sequences to visualize central airways in static...... perform spirometry controlled breathing maneuvers (peak flow and coughing) using a MRI compatible spirometer. “Static” 13-second breath-hold scans covering the entire thoracic region were acquired at end-inspiration and end-expiration using a 3D GRE with TR/TE=1.2/0.5 ms, alpha = 2, sagittal isotropic...... the required breathing maneuvers. Images of central airways during static and dynamic conditions were acquired and could be analyzed. Three out of the 8 children had a TM just above the carina during forced expiration, confirmed by bronchoscopy. Conclusion: This pilot study shows that Dynamic-MRI is...

  16. Assessment of scientific research: a case-study of CERN

    Energy Technology Data Exchange (ETDEWEB)

    Martin, B.R.; Minchin, N.; Skea, J.; Peacock, T.; Crouch, D.; Irvine, J.

    1987-03-01

    The review aims to demonstrate that formal methods of evaluating research performance can play a valuable role in overcoming some of the problems with decision-making in basic science based on peer review. An approach which combines a number of research output indicators, including bibliometric measures derived from publication and citation analysis, is first outlined and then applied in a case study of the European Laboratory for Particle Physics, CERN, over the period 1961-1984.

  17. A social work study for assessment of entrepreneurs' personal characteristics

    OpenAIRE

    Ahmad Ahmadkhani; Mehrnaz Paknezhad; Ahmad Maaroufkhani

    2012-01-01

    The personality of an entrepreneur plays an important role on the success of creating new ideas. There are different characteristics such as courage, hardness, braveness, which could help an entrepreneur reach his/her goals. In this paper, we present an empirical study to learn more about students who are supposed to act as entrepreneur to create jobs in different fields of accounting, computer science, mechanical engineering, etc. In this paper, There are seven aspects of accepting reasonabl...

  18. A Comparative Study on Emerging Electric Vehicle Technology Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Ford, Jonathan [Sentech, Inc.; Khowailed, Gannate [Sentech, Inc.; Blackburn, Julia [Sentech, Inc.; Sikes, Karen [Sentech, Inc.

    2011-03-01

    Numerous organizations have published reports in recent years that investigate the ever changing world of electric vehicle (EV) technologies and their potential effects on society. Specifically, projections have been made on greenhouse gas (GHG) emissions associated with these vehicles and how they compare to conventional vehicles or hybrid electric vehicles (HEVs). Similar projections have been made on the volumes of oil that these vehicles can displace by consuming large amounts of grid electricity instead of petroleum-based fuels. Finally, the projected rate that these new vehicle fleets will enter the market varies significantly among organizations. New ideas, technologies, and possibilities are introduced often, and projected values are likely to be refined as industry announcements continue to be made. As a result, over time, a multitude of projections for GHG emissions, oil displacement, and market penetration associated with various EV technologies has resulted in a wide range of possible future outcomes. This leaves the reader with two key questions: (1) Why does such a collective range in projected values exist in these reports? (2) What assumptions have the greatest impact on the outcomes presented in these reports? Since it is impractical for an average reader to review and interpret all the various vehicle technology reports published to date, Sentech Inc. and the Oak Ridge National Laboratory have conducted a comparative study to make these interpretations. The primary objective of this comparative study is to present a snapshot of all major projections made on GHG emissions, oil displacement, or market penetration rates of EV technologies. From the extensive data found in relevant publications, the key assumptions that drive each report's analysis are identified and 'apples-to-apples' comparisons between all major report conclusions are attempted. The general approach that was taken in this comparative study is comprised of six primary

  19. A proposal to facilitate weight-of-evidence assessments: Harmonization of Neurodevelopmental Environmental Epidemiology Studies (HONEES)

    OpenAIRE

    Youngstrom, Eric; Kenworthy, Lauren; Lipkin, Paul H.; Goodman, Michael; Squibb, Katherine; Mattison, Donald R; Anthony, Laura Gutermuth; Makris, Susan L.; Bale, Ambuja S.; Raffaele, Kathleen C.; Judy S. LaKind

    2011-01-01

    The ability to conduct weight-of-evidence assessments to inform the assessment of potential environmental neurotoxicants is limited by lack of comparability of study methods, data analysis, and reporting. There is a need to establish consensus guidelines for conducting, analyzing, and reporting neurodevelopmental environmental epidemiologic studies, while recognizing that consistency is likewise needed for epidemiology studies examining other health outcomes. This paper proposes a set of cons...

  20. Study on Space Audit Assessment Criteria for Public Higher Education Institution in Malaysia: Space Capacity Assessment

    Directory of Open Access Journals (Sweden)

    Wan Hamdan Wan Samsul Zamani

    2016-01-01

    Full Text Available The aim of this study is to measure the capacity rate of learning space based on the as-built drawing provided by the institutions or if the as-built drawing is missing, the researcher have to prepare measured drawing as per actual on site. The learning space Capacity Index is developed by analyzing the space design in as-built drawing or measured drawing and the list of learning spaces available at the institution. The Capacity Index is classified according to the level of Usable Floor Area (UFA and Occupancy Load (OL according to learning space design capacity. The classification of Capacity Index is demonstrated through linguistic value and the color-coded key. From the said index, the institution can easily identify whether the existing learning space is currently best used or vice versa and standard space planning compliance in Malaysia Public Higher Education Institutions. The data will assist the management to clarify whether to maximize the use of existing space or to request for new learning space.

  1. SEASAT economic assessment. Volume 7: Marine transporation case study

    Science.gov (United States)

    1975-01-01

    The studies conducted of the potential use of SEASAT ocean condition data and resulting forecasts by dry cargo ships and tankers reached the following conclusions. The SEASAT ocean condition data and resulting forecasts could be usefully employed to route ships around storms, thereby resulting in reduced adverse weather damage, time loss and the related operating costs, and occasional catastrophic losses. These benefits are incremental benefits beyond those which present and future conventional ship routing procedures can supply. The values of the benefits are listed.

  2. FINAL REPORT ON THE AQUATIC MERCURY ASSESSMENT STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, N

    2008-09-30

    In February 2000, the United States Environmental Protection Agency (EPA) Region 4 issued a proposed Total Maximum Daily Load (TMDL) for total mercury in the middle and lower Savannah River. The initial TMDL, which would have imposed a 1 ng/l mercury limit for discharges to the middle/lower Savannah River, was revised to 2.8 ng/l in the final TMDL released in February 2001. The TMDL was intended to protect people from the consumption of contaminated fish, which is the major route of mercury exposure to humans. The most bioaccumulative form of mercury is methylmercury, which is produced in aquatic environments by the action of microorganisms on inorganic mercury. Because of the environmental and economic significance of the mercury discharge limits that would have been imposed by the TMDL, the Savannah River Site (SRS) initiated several studies concerning: (1) mercury in SRS discharges, SRS streams and the Savannah River, (2) mercury bioaccumulation factors for Savannah River fish, (3) the use of clams to monitor the influence of mercury from tributary streams on biota in the Savannah River, and (4) mercury in rainwater falling on the SRS. The results of these studies are presented in detail in this report. The first study documented the occurrence, distribution and variation of total and methylmercury at SRS industrial outfalls, principal SRS streams and the Savannah River where it forms the border with the SRS. All of the analyses were performed using the EPA Method 1630/31 ultra low-level and contaminant-free techniques for measuring total and methylmercury. Total mercury at National Pollutant Discharge Elimination System (NPDES) outfalls ranged from 0.31-604 ng/l with a mean of 8.71 ng/l. Mercury-contaminated groundwater was the source for outfalls with significantly elevated mercury concentrations. Total mercury in SRS streams ranged from 0.95-15.7 ng/l. Mean total mercury levels in the streams varied from 2.39 ng/l in Pen Branch to 5.26 ng/l in Tims Branch

  3. The Relationship between Studying Music and Mathematics Performance on the New Jersey High School Proficiency Assessment

    Science.gov (United States)

    Prokop, Kristie L.

    2011-01-01

    On assessments such as Trends in International Mathematics and Science Study (TIMSS) (Stigler & Hiebert, 1999) and Program for International Assessment (PISA) ("PISA 2006 Science Competencies for Tomorrow's World", 2007) students in the United States have not been performing as well in mathematics as students in other countries. In order for the…

  4. Assessing Researcher Interdisciplinarity: A Case Study of the University of Hawaii NASA Astrobiology Institute

    OpenAIRE

    Gowanlock, Michael G.; Gazan, Rich

    2012-01-01

    In this study, we combine bibliometric techniques with a machine learning algorithm, the sequential Information Bottleneck, to assess the interdisciplinarity of research produced by the University of Hawaii NASA Astrobiology Institute (UHNAI). In particular, we cluster abstract data to evaluate Thomson Reuters Web of Knowledge subject categories as descriptive labels for astrobiology documents, assess individual researcher interdisciplinarity, and determine where collaboration opportunities m...

  5. Assessment of Visuospatial Neglect in Stroke Patients Using Virtual Reality: A Pilot Study

    Science.gov (United States)

    Jannink, Michiel J. A.; Aznar, Miguel; de Kort, Alexander Cornelis; van de Vis, Wim; Veltink, Peter; van der Kooij, Herman

    2009-01-01

    One of the neuropsychological deficits that can result from a stroke is the neglect phenomenon. Neglect has traditionally been assessed with paper-and-pencil tasks, which are administered within the reaching space of a person. The purpose of this explorative study is to investigate whether it is possible to assess neglect in the extrapersonal…

  6. BASINS and WEPP Climate Assessment Tools (CAT): Case Study Guide to Potential Applications (External Review Draft)

    Science.gov (United States)

    This draft report supports application of two recently developed water modeling tools, the BASINS and WEPP climate assessment tools. The report presents a series of short case studies designed to illustrate the capabilities of these tools for conducting scenario based assessments...

  7. Values as a Bridge between Sustainability and Institutional Assessment: A Case Study from BOKU University

    Science.gov (United States)

    Ribeiro, Maria Miguel; Hoover, Elona; Burford, Gemma; Buchebner, Julia; Lindenthal, Thomas

    2016-01-01

    Purpose: The purpose of this paper is to illustrate that values-focused assessment can provide a useful lens for integrating sustainability and institutional performance assessment in universities. Design/methodology/approach: This study applies a values elicitation methodology for indicator development, through thematic analysis of…

  8. Assessing Long-Term Effects of Inquiry-Based Learning: A Case Study from College Mathematics

    Science.gov (United States)

    Kogan, Marina; Laursen, Sandra L.

    2014-01-01

    As student-centered approaches to teaching and learning are more widely applied, researchers must assess the outcomes of these interventions across a range of courses and institutions. As an example of such assessment, this study examined the impact of inquiry-based learning (IBL) in college mathematics on undergraduates' subsequent grades…

  9. Interrogating the Generalizability of Portfolio Assessments of Beginning Teachers: A Qualitative Study

    Science.gov (United States)

    Moss, Pamela A.; Sutherland, LeeAnn M.; Haniford, Laura; Miller, Renee; Johnson, David; Geist, Pamela K.; Koziol, Stephen M., Jr.; Star, Jon R.; Pecheone, Raymond L.

    2004-01-01

    This qualitative study is intended to illuminate factors that affect the generalizability of portfolio assessments of beginning teachers. By generalizability, we refer here to the extent to which the portfolio assessment supports generalizations from the particular evidence reflected in the portfolio to the conception of competent teaching…

  10. Designing and Developing a Programme-Focused Assessment Strategy: A Case Study

    Science.gov (United States)

    Brunton, James; Brown, Mark; Costello, Eamon; Walsh, Elaine

    2016-01-01

    This case study describes the process that the Humanities Programme Team, in Dublin City University's Open Education Unit, has undertaken with regard to developing a systematic, programme-focused assessment strategy. It charts the development of an Assessment Matrix that facilitated the enhancement of programme coherence in the context of a…

  11. Health Literacy Assessment of the STOFHLA: Paper versus Electronic Administration Continuation Study

    Science.gov (United States)

    Chesser, Amy K.; Keene Woods, Nikki; Wipperman, Jennifer; Wilson, Rachel; Dong, Frank

    2014-01-01

    Low health literacy is associated with poor health outcomes. Research is needed to understand the mechanisms and pathways of its effects. Computer-based assessment tools may improve efficiency and cost-effectiveness of health literacy research. The objective of this preliminary study was to assess if administration of the Short Test of Functional…

  12. Information Literacy and Communication Research: A Case Study on Interdisciplinary Assessment

    Science.gov (United States)

    Natalle, Elizabeth J.; Crowe, Kathryn M.

    2013-01-01

    This report offers an interdisciplinary approach for conducting assessment on learning outcomes in undergraduate communication research skills where information literacy is embedded in the expected outcome. A Communication Studies department and the University Library piloted a two-year program to develop strategies for coordinated assessment that…

  13. Changes and Possibilities: A Case Study of Nova Scotia Classroom Assessment Policies

    Science.gov (United States)

    Van Zoost, Steven

    2011-01-01

    Although numerous writers have identified a different set of skills needed for employment in New Times, little analytic attention has been paid to how educational assessment policies contribute to envisioning such future citizens. This case study illustrates how Nova Scotia classroom assessment policy for Grades 7-9 English classes envisions young…

  14. Capacity Building as a Tool for Assessing Training and Development Activity: An Indian Case Study

    Science.gov (United States)

    Krishnaveni, R.; Sripirabaa, B.

    2008-01-01

    In recognition of its increasing importance, many organizations make periodic assessments of their training and development activity. The objective of the present study was to extend the concept of capacity building to the assessment of training and development activity in an automobile component manufacturing organization, using a developed and…

  15. An Internet-Based Telerehabilitation System for the Assessment of Motor Speech Disorders: A Pilot Study

    Science.gov (United States)

    Hill, Anne J.; Theodoros, Deborah G.; Russell, Trevor G.; Cahill, Louise M.; Ward, Elizabeth C.; Clark, Kathy M.

    2006-01-01

    Purpose: This pilot study explored the feasibility and effectiveness of an Internet-based telerehabilitation application for the assessment of motor speech disorders in adults with acquired neurological impairment. Method: Using a counterbalanced, repeated measures research design, 2 speech-language pathologists assessed 19 speakers with…

  16. Reactor physics studies for assessment of tramp uranium methods

    International Nuclear Information System (INIS)

    This paper presents calculation studies towards validation of a methodology for estimations of the tramp uranium mass from water chemistry measurements. Particular emphasis is given to verify, from a reactor physics point of view, the justification basis for the so-called 'Pu-based model' versus the 'U-based model' as a key assumption for the methodology. The computational studies are carried out for a typical BWR fuel assembly with CASMO-5M and MCNPX. By approximating the evolution of fissile nuclides and the fraction of 235U fissions to total fissions in different zones of a fuel rod, including tramp uranium on the clad surface, it is found that Pu gives the dominant contribution to fissions for tramp uranium after an irradiation on the outer clad surface of at least one cycle in a BWR. Thus, the use of the so-called Pu model for the determination of the tramp uranium mass (this means in particular using the yields for 239Pu fission) appears justified in the cases considered. On that basis, replacing the older U model by a Pu model is recommended. (authors)

  17. Reactor physics studies for assessment of tramp uranium methods

    Energy Technology Data Exchange (ETDEWEB)

    Grimm, P.; Vasiliev, A.; Wieselquist, W.; Ferroukhi, H. [Paul Scherrer Institut, CH 5232 Villigen (Switzerland); Ledergerber, G. [Kernkraftwerk Leibstadt AG, CH 5325 Leibstadt (Switzerland)

    2012-07-01

    This paper presents calculation studies towards validation of a methodology for estimations of the tramp uranium mass from water chemistry measurements. Particular emphasis is given to verify, from a reactor physics point of view, the justification basis for the so-called 'Pu-based model' versus the 'U-based model' as a key assumption for the methodology. The computational studies are carried out for a typical BWR fuel assembly with CASMO-5M and MCNPX. By approximating the evolution of fissile nuclides and the fraction of {sup 235}U fissions to total fissions in different zones of a fuel rod, including tramp uranium on the clad surface, it is found that Pu gives the dominant contribution to fissions for tramp uranium after an irradiation on the outer clad surface of at least one cycle in a BWR. Thus, the use of the so-called Pu model for the determination of the tramp uranium mass (this means in particular using the yields for {sup 239}Pu fission) appears justified in the cases considered. On that basis, replacing the older U model by a Pu model is recommended. (authors)

  18. Feasibility studies of safety assessment methods for programmable automation systems. Final report of the AVV project

    International Nuclear Information System (INIS)

    Feasibility studies of two different groups of methodologies for safety assessment of programmable automation systems has been executed at the Technical Research Centre of Finland (VTT). The studies concerned the dynamic testing methods and the fault tree (FT) and failure mode and effects analysis (FMEA) methods. In order to get real experience in the application of these methods, an experimental testing of two realistic pilot systems were executed and a FT/FMEA analysis of a programmable safety function accomplished. The purpose of the studies was not to assess the object systems, but to get experience in the application of methods and assess their potentials and development needs. (46 refs., 21 figs.)

  19. Assessment during the Integration of Lesson Study in Microteaching among Pre-service Teachers

    Directory of Open Access Journals (Sweden)

    Zanaton H Iksan

    2013-11-01

    Full Text Available Lesson Study is an approach used for critical analysis during the teaching and learning process. The effectiveness of this approach was proven when the Ministry of Education implemented it by stages in schools. This approach was also used to enhance the development process in the teaching profession. In conjunction with this, the science program students from the Faculty of Education were also given early exposure to Lesson Study. This approach was applied by integrating it in the teaching methods through simulated microteaching. Thus, the purpose of this study was to observe the assessment process in microteaching, which integrated with the approach of Lesson Study. This study was carried out in the Chemical Teaching Methods Course in the Faculty of Education, Universiti Kebangsaan Malaysia (UKM. It focused on how the pre-service teachers assessed the elements in microteaching. A total of 27 pre-service teachers were involved in the qualitative study. This study was carried out in one 14-weeks semester. This study involved the collection and qualitative analysis of data. Data sources were derived from observation, interviews, written reports by pre-service teachers, audio recordings (mp3, and video that was transcribed verbatim. Triangulation was done on each of the data sources. The findings showed that, through Lesson Study in microteaching, pre-service teachers were able to construct skills in doing assessment based on the lesson plan, teaching approach, and students’ behaviour. Findings from this study had a positive impact on the pre-service teachers in making assessments. This is due to the fact that the microteaching of Lesson Study allowed the pre-service teachers to construct their skills in doing assessments during the lessons. The construction of these skills is important because of the school-based assessment that focuses on the assessment process is being implemented in the school curriculum in Malaysia. Hence, the construction

  20. Environmental Assessment of a Waste Incineration Tax. Case Study and Evaluation of a Framework for Strategic Environmental Assessment

    International Nuclear Information System (INIS)

    A framework for Strategic Environmental Assessment (SEA) is tested in a case study on a proposed waste incineration tax. Also included is testing of developed methods for valuation and site-dependent life cycle impact assessment. The results indicate that although a suggested waste incineration tax of 400 SEK/ton is likely to lead to environmental improvements, these are small compared to the potential improvements as shown in more visionary scenarios. In order to go in this direction a waste incineration tax based on the content of fossil carbon in the waste would be useful. The framework for SEA includes several different pathways. These have different advantages and disadvantages and provide different types of information. It is therefore suggested that they largely complement each other and that the choice of methods should be done in relation to the function of the SEA and the questions asked.

  1. Environmental Assessment of a Waste Incineration Tax. Case Study and Evaluation of a Framework for Strategic Environmental Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerklund, Anna; Johansson, Jessica [Swedish Defence Research Agency, Stockholm (Sweden); Nilsson, Maans [Stockholm Environment Inst., Stockholm (Sweden); Eldh, Peter; Finnveden, Goeran [Royal Inst. of Technology, Stockholm (Sweden). Dept. of Industrial Ecology

    2003-12-01

    A framework for Strategic Environmental Assessment (SEA) is tested in a case study on a proposed waste incineration tax. Also included is testing of developed methods for valuation and site-dependent life cycle impact assessment. The results indicate that although a suggested waste incineration tax of 400 SEK/ton is likely to lead to environmental improvements, these are small compared to the potential improvements as shown in more visionary scenarios. In order to go in this direction a waste incineration tax based on the content of fossil carbon in the waste would be useful. The framework for SEA includes several different pathways. These have different advantages and disadvantages and provide different types of information. It is therefore suggested that they largely complement each other and that the choice of methods should be done in relation to the function of the SEA and the questions asked.

  2. Overheating Assessment of a Passive House Case Study in Spain

    DEFF Research Database (Denmark)

    Hidalgo, Juan María; Psomas, Theofanis Ch.; García-Gáfaro, Carlos;

    2015-01-01

    In response to the European Energy Performance Buildings Directive 2010/31/EU and the Energy Efficiency Directive 2012/27/EU, buildings have increasingly become more insulated in order to reduce the heating losses to a minimum. However, this could also lead to the problem of indoor high...... family house built in Spain according to the Passivhaus standard. For the purpose of this research, we selected the following models: the Fanger Predicted Mean Vote (PMV) model defined in the ISO 7730:2005, the adaptive model defined in the EN 15251:2007, the criteria for overheating prevention defined...... in CIBSE TM52 in 2013 and the PH limitation about warmer temperatures. Moreover, we have analysed the influence of dwelling occupancy and the periods of verification over the results of each methodology. The studied building has a high level of thermal insulation and air-tight envelope, reducing heat...

  3. Preliminary systems design study assessment report. Volume 7, Subsystem concepts

    Energy Technology Data Exchange (ETDEWEB)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex`s Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each. This volume contains the descriptions and other relevant information of the four subsystems required for most of the ex situ processing systems. This volume covers the metal decontamination and sizing subsystem, soils processing subsystem, low-level waste subsystem, and retrieval subsystem.

  4. RISK CONCEPT AND RISK ASSESSMENT IN EPIDEMIOLOGIC STUDIES

    Directory of Open Access Journals (Sweden)

    Gamze CAN

    2006-10-01

    Full Text Available Basic aim of an epidemiological study is to quantify the association between the exposure and the outcome of interest. To achieve this, the incidence of disease in a group of individuals exposed to the putative risk factors must be compared with the incidence in a group of persons not exposed. This comparison can be summarized by calculating either the ratio of the measures of disease occurrence for the two groups, which indicates the likelihood of developing the disease in the exposed individuals relative to those unexposed, or the difference between the two, which provides information about the absolute effect of the exposure in those exposed compared with those unexposed. Some terms about relative risk were explained and examine with samples in this article. [TAF Prev Med Bull 2006; 5(5.000: 374-381

  5. Study of the Gastric Emptying in Humans: Biomagnetic Assessments

    Science.gov (United States)

    Hernández, E.; Córdova, T.; Huerta-Franco, R.; Sosa, M.; Vargas-Luna, M.

    2006-09-01

    Biomagnetic studies of the gastrointestinal system can be carried out in two ways. Recording the magnetic field produced by the myenteric nervous system or created by any oral contrast mean as magnetic tracers or markers. In the first case, a SQUID magnetometer is demanded while a fluxgate magnetometer is enough in the second case. In this work, a magnetic marker was ingested by 8 healthy volunteers, in three gastric volume conditions, to measure the luminal content volume effect in the gastric emptying and to perform the quantification of the peristaltic frequencies in gastric and duodenum tract segments. The average emptying times for low luminal content, relative to the emptying time when the intake was the highest, were 43.6 ± 15.6 % and 77.3 ± 47.0 %. These results show that the biomagnetic technique is a powerful modality to estimate the effects of the gastric volume in the gastric emptying and a way to record the peristaltic frequencies.

  6. Robot-assisted home hazard assessment for fall prevention: a feasibility study.

    Science.gov (United States)

    Sadasivam, Rajani S; Luger, Tana M; Coley, Heather L; Taylor, Benjamin B; Padir, Taskin; Ritchie, Christine S; Houston, Thomas K

    2014-01-01

    We examined the feasibility of using a remotely manoeuverable robot to make home hazard assessments for fall prevention. We employed use-case simulations to compare robot assessments with in-person assessments. We screened the homes of nine elderly patients (aged 65 years or more) for fall risks using the HEROS screening assessment. We also assessed the participants' perspectives of the remotely-operated robot in a survey. The nine patients had a median Short Blessed Test score of 8 (interquartile range, IQR 2-20) and a median Life-Space Assessment score of 46 (IQR 27-75). Compared to the in-person assessment (mean = 4.2 hazards identified per participant), significantly more home hazards were perceived in the robot video assessment (mean = 7.0). Only two checklist items (adequate bedroom lighting and a clear path from bed to bathroom) had more than 60% agreement between in-person and robot video assessment. Participants were enthusiastic about the robot and did not think it violated their privacy. The study found little agreement between the in-person and robot video hazard assessments. However, it identified several research questions about how to best use remotely-operated robots. PMID:24352900

  7. A feasibility study of conducting the Montreal Cognitive Assessment remotely in individuals with movement disorders.

    Science.gov (United States)

    Abdolahi, Amir; Bull, Michael T; Darwin, Kristin C; Venkataraman, Venayak; Grana, Matthew J; Dorsey, E Ray; Biglan, Kevin M

    2016-06-01

    Remote assessments of individuals with a neurological disease via telemedicine have the potential to reduce some of the burdens associated with clinical care and research participation. We aim to evaluate the feasibility of conducting the Montreal Cognitive Assessment remotely in individuals with movement disorders. A pilot study derived from two telemedicine trials was conducted. In total, 17 individuals with movement disorders (8 with Parkinson disease and 9 with Huntington disease) had Montreal Cognitive Assessment examinations evaluated in-person and remotely via web-based video conferencing to primarily determine feasibility and potential barriers in its remote administration. Administering the Montreal Cognitive Assessment remotely in a sample of movement disorder patients with mild cognitive impairment is feasible, with only minor common complications associated with technology, including delayed sound and corrupted imaging for participants with low connection speeds. The Montreal Cognitive Assessment has the potential to be used in remote assessments of patients and research participants with movement disorders. PMID:25391849

  8. Assessment and seasonal variations of communicable diseases: 3 year study

    Directory of Open Access Journals (Sweden)

    D. Kalyani

    2016-04-01

    Results: Results showed that a total of 34,981 had been treated at the inpatient departments from the year 2011 to 2013. It was observed that communicable diseases constituted about 85% (30,082 of the total disease burden with viral infections being the commonest. Most of the diseases were observed to have a seasonal variation. The most common disease identified was viral fever 8713 (28.96%, secondly acute diarrheal diseases 7965(26.52% followed by enteric fever 2958 (9.83% and malaria 2443(8.12%. The least common were Rabies 80 (0.26 % and pertussis 37 (0.12%. Outbreaks of Measles and Diphtheria were also noted in this study. Conclusions: Many diseases have a seasonal variation and the burden of these diseases could be reduced if we device measures to detect the changes in their trend through the implementation of surveillance programs. The knowledge of the burden of these would also assist the health administrators in allocation of the resources. [Int J Res Med Sci 2016; 4(4.000: 1186-1192

  9. Isotope studies to assess water development in mining dump sites

    International Nuclear Information System (INIS)

    After the ending of the lignite exploitation open mining pits with dump sites of heterogeneous mixture of Tertiary and Quaternary sediments were flooded by groundwater and river water inflow forming partially acidic (pH about 2 to 3) mining lakes with high sulphate (>3000 mg/L) and iron content (>500 mg/L) (Friese et al., 1998). The renewing of the groundwater system in mining areas is a very complicated process. The knowledge of the whole as well as of parts of that process is important for the future water management and for land use. Acidification of surface and groundwater based on pyrite oxidation dominates water quality development of the groundwater and of the flooded pits. The different sulphur compounds and the distribution of sulphur sources (pyrite, sulphate, sulphide) can easily controlled by the sulphur and oxygen isotope analyses. Our studies are focused on an acidic mine lake ML 111 in the Lusatian Lignite District and on the Cospuden lignite mine south of Leipzig

  10. COMPARATIVE STUDY ON MAIN SOLVENCY ASSESSMENT MODELS FOR INSURANCE FIELD

    Directory of Open Access Journals (Sweden)

    Daniela Nicoleta SAHLIAN

    2015-07-01

    Full Text Available During the recent financial crisis of insurance domain, there were imposed new aspects that have to be taken into account concerning the risks management and surveillance activity. The insurance societies could develop internal models in order to determine the minimum capital requirement imposed by the new regulations that are to be adopted on 1 January 2016. In this respect, the purpose of this research paper is to offer a real presentation and comparing with the main solvency regulation systems used worldwide, the accent being on their common characteristics and current tendencies. Thereby, we would like to offer a better understanding of the similarities and differences between the existent solvency regimes in order to develop the best regime of solvency for Romania within the Solvency II project. The study will show that there are clear differences between the existent Solvency I regime and the new approaches based on risk and will also point out the fact that even the key principles supporting the new solvency regimes are convergent, there are a lot of approaches for the application of these principles. In this context, the question we would try to find the answer is "how could the global solvency models be useful for the financial surveillance authority of Romania for the implementation of general model and for the development of internal solvency models according to the requirements of Solvency II" and "which would be the requirements for the implementation of this type of approach?". This thing makes the analysis of solvency models an interesting exercise.

  11. Physiochemical study of NSSC effluents and assessment of principal pollutants

    International Nuclear Information System (INIS)

    Waste effluents collected from different processing units of a pulp-mill were analyzed for various physiochemical parameters i.e. appearance, pH, conductance, total dissolved and suspended solids (TDS and TSS), chemical oxygen demand (COD) and 5- days biochemical oxygen demand (BOD/sub 5/). Various ions with reference to pulping process were investigated in these effluents which include Cr, SO/sub 4/sup 2-/, SO/sub 3/sup 2-/, CO/sub 3/sup 2-/HCO/sub 3/sup 1-/, Na/sup +/, K/sup +/, Mg/sup +2/ and Ca/sup +2/. Heavy metals like Hg, Pb, Fe, Cr, Cu and Zn was also determined by atomic absorption spectrometry. The results were compared with National Environmental Quality Standards for industrial effluents. Most of the parameters were found outside the permissible limits except the temperature, pH and few cations. Effluents from NSSC process exhibited highest values of TDS, TSS, COD and BODs (these are 103174, 31866, 23340, 6864 mg/l respectively). Chief polluting characteristics of these effluents were found to be the dissolved chemicals and suspended organic matter, which are responsible for very high COD and BODs values. This study was: an effort to monitor the concentration of various pollutants in the waste effluents of pulp and paper industry with special emphasis on NSSC effluents and their contribution in environmental pollution. The hazardous effects of these effluents and different treatment methodologies have also been discussed. (author)

  12. Assessment of Social Media Utilization and Study Habit of Students of Tertiary Institutions in Katsina State

    Science.gov (United States)

    Olutola, Adekunle Thomas; Olatoye, Olufunke Omotoke; Olatoye, Rafiu Ademola

    2016-01-01

    This study investigated assessment of social media utilization and study habits of students of tertiary institutions in Katsina State. The descriptive survey design was adopted for this study. Three hundred and eighty-one (381) students' of tertiary institutions in Katsina State were randomly selected for the study. Researchers'-designed…

  13. Understanding Authentic Assessment in a Secondary Agricultural Mechanics Laboratory: An Instrumental Case Study

    Directory of Open Access Journals (Sweden)

    J. Joey Blackburn

    2013-06-01

    Full Text Available The instrumental case study reported here adds to the literature on authentic assessment by illuminating how one secondary agricultural education instructor employed authentic assessment in the agricultural mechanics laboratory. The study was underpinned by the constructivist notion of authentic learning and assessment, or allowing students to perform what they can do. Multiple sources of data regarding assessment practices were collected from an exemplary secondary agricultural mechanics instructor who demonstrated model authentic assessment behavior by (1 setting high and fair expectations for students, (2 establishing a progressive hierarchy of skills for students to master, (3 providing continuous feedback so that students had knowledge of their progress, and (4 being committed deeply to students’ success. The four themes resonated with previous literature and provided the foundation for a pragmatic model of authentic assessment in the secondary agricultural mechanics laboratory. Future research should focus on refining the model of authentic assessment in agricultural mechanics for a larger audience, as case studies are limited in their ability to generalize. Additionally, research should be conducted to determine how authentic assessment impacts student performance on Oklahoma Agricultural Power and Technology competency examinations.

  14. Assessing atmospheric temperature data sets for climate studies

    Directory of Open Access Journals (Sweden)

    Magnus Cederlöf

    2016-07-01

    Full Text Available Observed near-surface temperature trends during the period 1979–2014 show large differences between land and ocean, with positive values over land (0.25–0.27 °C/decade that are significantly larger than over the ocean (0.06–0.12 °C/decade. Temperature trends in the mid-troposphere of 0.08-0.11 °C/decade, on the other hand, are similar for both land and ocean and agree closely with the ocean surface temperature trend. The lapse rate is consequently systematically larger over land than over the ocean and also shows a positive trend in most land areas. This is puzzling as a response to external warming, such as from increasing greenhouse gases, is broadly the same throughout the troposphere. The reduced tropospheric warming trend over land suggests a weaker vertical temperature coupling indicating that some of the processes in the planetary boundary layer such as inversions have a limited influence on the temperature of the free atmosphere. Alternatively, the temperature of the free atmosphere is influenced by advection of colder tropospheric air from the oceans. It is therefore suggested to use either the more robust tropospheric temperature or ocean surface temperature in studies of climate sensitivity. We also conclude that the European Centre for Medium-Range Weather Forecasts Reanalysis Interim can be used to obtain consistent temperature trends through the depth of the atmosphere, as they are consistent both with near-surface temperature trends and atmospheric temperature trends obtained from microwave sounding sensors.

  15. Risk assessment after coronary angioplasty with SPECT myocardial perfusion studies

    International Nuclear Information System (INIS)

    The chest pain can be use for stratifying the risk of the patients after coronary angioplasty. Nevertheless this strategy has shown to have a low accuracy in the detection of restenosis and myocardial ischemia. Aims: To establish the usefulness of the SPECT studies in the risk stratification after the coronary angioplasty. Evaluate the incidence of silent ischemia or symptomatic, and its impact on the prognosis. Method: There were included 107 patients (p) submitted to a gated SPECT between the year of the coronary angioplasty. The analysis of the images was performed according to different scores (SSS, SRS, SDS). These data was correlated with the symptoms of the patients. We define group 1 (G1) as the asymptomatic without ischemia (n 59p), group 2 (G2) as silent ischemia (n = 28p) and group 3 (G3) as symptomatic with ischemia (n = 20p). A clinical follow-up was done in search of events (target vessel revascularization, unstable angina, AMI and death). Results: Significant differences were not observed in the clinical variables between the different groups. The SSS was lower in the G1 compare with G2 and G3 (p 0.0001) and was similar between the last two, p = NS (SSS: G1: 2.2 ± 4.9; G2: 7.6 ± 5.9; G3: 9.5 ± 6.8). The SDS was greater in G3 vs. G1 and G2, p = 0.0001, and greater in G2 vs. G1, p = 0.0001 (SDS: G1: 0; G2: 4.8 ± 3.5; G3: 7.2 ± 6.5). No differences where observed in the SRS between the three groups. In the follow-up the total percentage of events was lesser when compare the G1 with the G2 and G3 (G1: 3.3%; G2 and G3: 18.7%; p 0.02). The percentage of annual events of the G3 symptomatic with ischemia (11.03%) and G2 silent ischemia (4.04%) did not present differences (p 0.7). When the events of the G2 (4.04%) were compared with the G1 (1.24%) we observed a trend to major frequency of events in the G2 (p = 0.6). Conclusions: The presence of myocardial ischemia after coronary angioplasty is a determinant of the prognosis. Nevertheless, the extension

  16. Assessment of subtalar joint neutral position:a cadaveric study

    Institute of Scientific and Technical Information of China (English)

    CHEN Yan-xi; YU Guang-rong; MEI Jiong; ZHOU Jia-qian; WANG Wen

    2008-01-01

    Background Subtalar joint(STJ)neutral position is the position typically used by clinicians to obtain a cast representation of a patient's foot before fabrication of biomechanical functional orthosis. But no method for measuring STJ neutral position has been proven accurate and reproducible by different testers. This study was conducted to investigate the STJ neutral position in normal feet in cadavers. Methods Twelve fresh-frozen specimens of amputated lower legs were used. Pressure-sensitive films were inserted into the anterior and posterior articulation of STJ. The contact areas for various foot positions and under axial loads of 600 N were determined based on the gray level of the digitized film. The STJ neutral positions were determined as the ankle-foot position where the maxlmum contact area was achieved, because the neutral position of a joint was defined as the position where the concave and convex surfaces were completely congruous. Results In ankle-foot neutral position, the contact area of STJ was(2.79±0.24)cm2. In the range of motion of adduction-abduction (ADD-ABD), the maximum contact area was(3.00±0.26)cm2 when the foot was positioned 10°of ABD (F=221.361, P<0.05). In the range of motion of dorsiflexion-plantarflexion (DF-PF), the maximum contact area was (3. 61±0. 25)cm2 when the foot was positioned 20°of DF(F=121.067, P<0.05). In the range of motion of inversion-eversion (INV-EV), the maximum contact area was(3. 14+0.26)cm2 when the foot was positioned 10°of EV(F=256. 252, P<0.05). Conclusions Joints, such as STJ, therefore, are not necessarily in neutral position when the ankle. foot is placed in the traditional concept of neutral position. The results demonstrate that the most approximate STJ neutral position was in the foot position of 10°of abduction, 20°of dorsiflexion and 10°of eversion.

  17. Dta points used in assessment of coal in the southern Piceance basin study area (psptg)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This is a shapefile and point coverage of 627 data points used in the assessment of coal in the southern Piceance Basin study area. Information in this file...

  18. INFLUENCE OF EXPOSURE ASSESSMENT METHOD IN AN EPIDEMIOLOGIC STUDY OF TRIHALOMETHANE EXPOSURE AND SPONTANEOUS ABORTION

    Science.gov (United States)

    Trihalomethanes are common contaminants of chlorinated drinking water. Studies of their health effects have been hampered by exposure misclassification, due in part to limitations inherent in using utility sampling records. We used two exposure assessment methods, one based on ut...

  19. Quality Assessment Study of Brief Psychotherapy at a University HMO Setting.

    Science.gov (United States)

    Poey, Kent

    1981-01-01

    The results of a short-term psychotherapy quality assessment study, conducted at a university mental health service, are described. The outcome indicates that high-quality brief psychotherapy can be provided by university counseling services. (JN)

  20. Prospective Assessment of Cannabis Withdrawal in Adolescents with Cannabis Dependence: A Pilot Study

    Science.gov (United States)

    Milin, Robert; Manion, Ian; Dare, Glenda; Walker, Selena

    2008-01-01

    A study to identify and assess the withdrawal symptoms in adolescents afflicted with cannabis dependence is conducted. Results conclude that withdrawal symptoms of cannabis were present in adolescents seeking treatment for this substance abuse.

  1. Evaluation on the Feasibility of Using Ultrasonic Testing of Reactor Pressure Vessel Welds for Assessing Flaw Density/Distribution per 10 CFR 50.61a, Alternate Fracture Toughness Requirements for Protection Against Pressurized Thermal Shock

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, Edmund J.; Anderson, Michael T.

    2014-06-10

    This technical letter report provides the status of an assessment undertaken by PNNL at the request of the NRC to verify the capability of periodic ASME-required volumetric examinations of reactor vessels to characterize the density and distribution of flaws of interest for applying §50.61a on a plant-by-plant basis. The PTS rule, described in the Code of Federal Regulations, Title 10, Section 50.61 (§50.61), "Fracture Toughness Requirements for Protection against Pressurized Thermal Shock Events," establishes screening criteria to ensure that the potential for a reactor vessel to fail due to a PTS event is deemed to be acceptably low. Recently, the NRC completed a research program that concluded that the risk of through-wall cracking due to a PTS event is much lower than previously estimated. The NRC subsequently developed and promulgated an alternate PTS rule, §50.61a, that can be implemented by PWR licensees. The §50.61a rule differs from §50.61 in that it requires licensees who choose to follow this alternate method to analyze the results from periodic volumetric examinations required by the ASME Code, Section XI, Rules for Inservice Inspection (ISI) of Nuclear Power Plants.

  2. A study on the effectiveness of self-assessment and peer assessment in the oral production of secondary EFL learners and CLIL learners

    OpenAIRE

    León Herrera, Yasmina

    2014-01-01

    This study compares the effects of peer assessment (PA) and self-assessment (SA) in the oral production of secondary English as a Foreign Language (EFL) students, half of them studying Maths in English in a Content and Language Integrated Learning (CLIL) model. The study examines the oral productions after three weeks of treatment comparing first, second and third recorded performances. In order to investigate the effectiveness of these two types of assessments, the treatment w...

  3. Profiling postgraduate workplace-based assessment implementation in Ireland: a retrospective cohort study

    OpenAIRE

    Barrett, Aileen; Galvin, Rose; Steinert, Yvonne; Scherpbier, Albert; O’Shaughnessy, Ann; Walsh, Gillian; Horgan, Mary

    2016-01-01

    In 2010, workplace-based assessment (WBA) was formally integrated as a method of formative trainee assessment into 29 basic and higher specialist medical training (BST/HST) programmes in six postgraduate training bodies in Ireland. The aim of this study is to explore how WBA is being implemented and to examine if WBA is being used formatively as originally intended. A retrospective cohort study was conducted and approved by the institution’s Research Ethics Committee. A profile of WBA require...

  4. An assessment of five different theoretical frameworks to study the uptake of innovations

    OpenAIRE

    Botha, Neels; Atkins, Kris

    2005-01-01

    There are several theoretical frameworks one can draw upon to study the adoption process. Extension Theory, Bounded Rationality, Diffusion Theory, the Theory of Reasoned Action and Consumer Behaviour Theory were of particular interest to us. In assessing the frameworks we looked for contradictions, and how and whether these frameworks could be used to study the adoption process. The assessment was done by using our own conceptual framework of the adoption process and we discuss the results in...

  5. Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies

    OpenAIRE

    Bossuyt Patrick NM; Reitsma Johannes B; Rutjes Anne WS; Weswood Marie E; Whiting Penny F; Kleijnen Jos

    2006-01-01

    Abstract Background A quality assessment tool for diagnostic accuracy studies, named QUADAS, has recently been developed. Although QUADAS has been used in several systematic reviews, it has not been formally validated. The objective was to evaluate the validity and usefulness of QUADAS. Methods Three reviewers independently rated the quality of 30 studies using QUADAS. We assessed the proportion of agreements between each reviewer and the final consensus rating. This was done for all QUADAS i...

  6. Need Assessment for Sex Education amongst the University Students –A Pilot Study

    OpenAIRE

    Jaideep Kumar

    2012-01-01

    Background: The morbidity associated with sexual ignorance, poor decision making and inadequate sexuality education is rising in India day by day. The possibility of sex related public health problems like sexual abuse, teenage pregnancies, abortions, unmarried motherhood, STD/HIV infections etc. are always remains high in university students. In this background to assess the student’s knowledge & perceived need for sex education this study was conducted. Objective Of Study: To assess the nee...

  7. Reproducibility in echocardiographic assessment of diastolic function in a population based study (the STANISLAS Cohort study.

    Directory of Open Access Journals (Sweden)

    Zied Frikha

    Full Text Available There is limited evidence regarding intra-observer and inter-observer variations in echocardiographic measurements of diastolic function. This study aimed to assess this reproducibly within a population-based cohort study.Sixty subjects in sinus rhythm were randomly selected among 4th visit participants of the STANISLAS Cohort (Lorraine region, France. This 4th examination systematically included M-mode, 2-dimensional, DTI and pulsed-wave Doppler echocardiograms. Reproducibility of variables was studied by intra-class correlation coefficients (ICC and Bland Altman plots.Our population was on average middle-aged (50 ± 14 y, overweight (BMI = 26 ± 6 kg/m2 and non-smoking (87% with a quarter of the participants having self-declared hypertension or treated with anti-hypertensive medication(s. Intra-observer ICC were > 0.90 for all analyzed parameters except for left ventricular ejection fraction (LVEF which was 0.89 (0.81-0.93. The mean relative intra-observer differences were small and limits of agreement of relative differences were narrow for all considered parameters ( 0.90 for all analyzed parameters except for LVEF (ICC = 0.87 and both mitral and pulmonary A wave duration (0.83 and 0.73 respectively. The mean relative inter-observer differences were <5% for all parameters except for pulmonary A wave duration (mean difference = 6.5%. Limits of agreement of relative differences were narrow (<15%, except for mitral A wave duration and velocity (both <20% as well as left ventricular mass and pulmonary A wave duration (both <30%. Intra-observer agreements with regard to the presence and severity of diastolic dysfunction were excellent (Kappa = 0.93 (0.83-1.00 and 0.88 (0.75-0.99, respectively.In this validation study within the STANISLAS cohort, diastolic function echocardiographic parameters were found to be highly reproducible. Diastolic dysfunction consequently appears as a highly effective clinical and research tool.

  8. Assessment

    Directory of Open Access Journals (Sweden)

    D.F. Cortés-Rojas

    2016-07-01

    Full Text Available Spray drying has been successfully employed for the encapsulation of herbal bioactive compounds resulting in stable phytopharmaceutical preparations. Bidens pilosa L. is a South American medicinal plant with proved antimalaric, hepatoprotector and antioxidant activities, generally linked to their secondary metabolites, flavonoids and polyacetylenes. In this work the physicochemical stability of an optimized spray dried composition from a B. pilosa extract was evaluated at three different stress storage conditions in open containers and in sealed sachets. High performance liquid chromatography was employed to monitor the concentration of three marker compounds over 12 months. Color variation of the stored samples was evaluated by using a color spectrophotometer. It was observed that the concentration of the monitored compounds of the plant decreases more drastically in samples stored in open containers. The two flavonoids monitored, rutin and hyperoside, showed lower degradation than the polyacetylene. The concentration of the markers did not change significantly at the lowest temperature. With regard to color, darker hues were observed at higher temperatures and storage times. This study showed that the storage conditions cause significant impact on stability of standardized spray dried B. pilosa extract.

  9. A probabilistic safety assessment PEER review: Case study on the use of probabilistic safety assessment for safety decisions

    International Nuclear Information System (INIS)

    The purpose of this case study is to illustrate, using an actual example, the organizing and carrying out of an independent peer review of a draft full-scope (level 3) probabilistic safety assessment. The specific findings of the peer review are of less importance than the approach taken, the interaction between sponsor and study team, and the technical and administrative issues that can arise during a peer review. This case study will examine the following issues: how the scope of the peer review was established, based on how it was to be used by the review sponsoring body; how the level of effort was determined, and what this determination meant for the technical quality of the review; how the team of peer reviewers was selected; how the review itself was carried out; what findings were made; what was done with these findings by both the review sponsoring body and the PSA analysis team. 9 refs, 2 figs, 1 tab

  10. A study on assessment methodology of surveillance test interval and Allowed Outage Time

    Energy Technology Data Exchange (ETDEWEB)

    Che, Moo Seong; Cheong, Chang Hyeon; Ryu, Yeong Woo; Cho, Jae Seon; Heo, Chang Wook; Kim, Do Hyeong; Kim, Joo Yeol; Kim, Yun Ik; Yang, Hei Chang [Seoul National Univ., Seoul (Korea, Republic of)

    1997-07-15

    Objectives of this study is the development of methodology by which assesses the optimization of Surveillance Test Interval(STI) and Allowed Outage Time(AOT) using PSA method that can supplement the current deterministic methods and the improvement of Korean nuclear power plants safety. In the first year of this study, the survey about the assessment methodologies, modeling and results performed by domestic and international researches are performed as the basic step before developing the assessment methodology of this study. The assessment methodology that supplement the revealed problems in many other studies is presented and the application of new methodology into the example system assures the feasibility of this method. In the second year of this study, the sensitivity analyses about the failure factors of the components are performed in the bases of the assessment methodologies of the first study, the interaction modeling of the STI and AOT is quantified. And the reliability assessment methodology about the diesel generator is reviewed and applied to the PSA code.

  11. Assessing Motor Skill Competency in Elementary School Students: A Three-Year Study

    Science.gov (United States)

    Chen, Weiyun; Mason, Steve; Hypnar, Andrew; Bennett, Austin

    2016-01-01

    This study was to examine how well fourth- and fifth-grade students demonstrated motor skill competency assessed with selected PE Metrics assessment rubrics (2009). Fourth- and fifth-grade students (n = 1,346-1,926) were assessed on their performance of three manipulative skills using the PE Metrics Assessment Rubrics during the pre-intervention year, the post-intervention year 1, and the post-intervention year 3. Descriptive statistics, independent t-test, ANOVA, and follow-up comparisons were conducted for data analysis. The results indicated that the post-intervention year 2 cohort performed significantly more competent than the pre-intervention cohort and the post-intervention year 1 cohort on the three manipulative skill assessments. The post-intervention year 1 cohort significantly outperformed the pre-intervention cohort on the soccer dribbling, passing, and receiving and the striking skill assessments, but not on the throwing skill assessment. Although the boys in the three cohorts performed significantly better than the girls on all three skills, the girls showed substantial improvement on the overhand throwing and the soccer skills from baseline to the post-intervention year 1 and the post-intervention year 2. However, the girls, in particular, need to improve striking skill. The CTACH PE was conducive to improving fourth- and fifth-grade students’ motor skill competency in the three manipulative skills. This study suggest that PE Metrics assessment rubrics are feasible tools for PE teachers to assess levels of students’ demonstration of motor skill competency during a regular PE lesson. Key points CATCH PE is an empirically-evidenced quality PE curricular that is conducive to improving students’ manipulative skill competency. Boys significantly outperformed than girls in all three manipulative skills. Girls need to improve motor skill competency in striking skill. PE Metrics are feasible assessment rubrics that can be easily used by trained

  12. Continuous twice-a-day radiotherapy and concomitant CDDP-5FU chemotherapy (BiRCF) for the treatment of locally advanced inoperable pharyngeal carcinomas: final results of a multicentric phase II study (FNCLCC)

    International Nuclear Information System (INIS)

    Purpose: French 'Federation Nationale des Centres de Lutte Contre le Cancer' has initiated a phase II study in advanced pharynx cancer, to assess feasibility, local control at 6 months (mo), and control, survival and rate of distant metastases at 1 and 3 yr, obtained by a combined radio/chemotherapy regimen. Rationale was to associate, at full dose, most effective known treatments: (i) hyperfractionated continuous irradiation; and (ii) concurrent CDDP-5FU cycles. The inclusion of 30 to 35 cases was intended. Material and methods: Regardless of lymph nodes status, stage IV, not previously treated, unresectable carcinomas of oro- and hypopharynx were included. Eligibility criteria were KPS≥70, age≤65, acceptable renal, cardiac, and biological parameters. Patients (pts) were hospitalized during the overall treatment (trt) time (7 weeks), with enteral nutritional support and mucositis prevention. Supportive care included morphinomimetics and anti5HT3 antiemetics, without Colony Stimulating Factor. Radiotherapy (RT): Primary tumor and satellite nodes RT: 2 coaxial opposed lateral fields, 60Co γrays or 5-6 MV photons, 2 fractions (fr.) of 1.2 Gy/d., 5 days a week, without any interruption (D1->D46). Total tumor doses: 80.4 Gy/46 d. (oropharynx), 75.6 Gy/44 d. (hypopharynx). Spinal cord reduction at 40.8 Gy (complement with 7-10 MeV e-, 1 fr./d., 2 Gy/fr.). Supra-clavicular RT: 1 anterior field, 1 fr./d., 2 Gy/fr., total dose 50 Gy + e-. Chemotherapy consisted of CDDP: 100 mg/m2 (D1); 5FU: 750 mg/m2/d., continuous infusion (D2->D6). Pharmacokinetically guided 5FU dose adaptation was performed at D4. 2nd cycle at D22; 3rd at D43. Results: For 30 included pts (06/03/95), acute toxicity was acceptable, with grade 3 mucositis in 23 cases, grade 4 mucositis in 5 cases (1 to 4 d. of duration), grade 4 transient neutropenia and/or thrombocytopenia in 6 cases, with no significant disturbance in trt course, i.e. no break > 5 d. during RT. Dose of 5FU was reduced at 2nd cycle

  13. Environmental health risk assessment of ambient lead levels in Lisbon, Portugal: A full chain study approach

    DEFF Research Database (Denmark)

    Casimiro, E.; Philippe Ciffroy, P.; Serpa, P.;

    2011-01-01

    useful for integrated full-chain human health risk assessments. In this study we use a newly developed computational tool – the 2FUN player to conduct a full-chain assessment combining measured ambient air lead concentrations with multi-media modelling and PBPK simulations to estimate the health risks...... calculate the Pb levels in the various body systems. Our results showed a low health risk from Pb exposures. It also identified that ingestion of leafy vegetables (i.e. lettuce, cabbage, and spinach) and fruits contribute the most to total Pb blood levels. This full chain assessment approach of the 2FUN...... player is likely to be very useful for local health risk assessment studies (i.e. EIA and SEA studies)....

  14. Aspects of brittle failure assessment for RPV

    Energy Technology Data Exchange (ETDEWEB)

    Zecha, H.; Hermann, T.; Hienstorfer, W. [TUeV SUeD Energietechnik GmbH Baden-Wuerttemberg, Filderstadt (Germany); Schuler, X. [Materialpruefungsanstalt, Univ. Stuttgart (Germany)

    2009-07-01

    This paper describes the process of pressurized thermal shock analysis (PTS) and brittle failure assessment for the reactor pressure vessel (RPV) of the nuclear power plants NECKAR I/II. The thermo-hydraulic part of the assessment provides the boundary conditions for the fracture mechanics analysis. In addition to the one dimensional thermo-hydraulic simulations CFD, analyses were carried out for selected transients. An extensive evaluation of material properties is necessary to provide the input data for a reliable fracture mechanics assessment. For the core weld and the flange weld it has shown that brittle crack initiation can be precluded for all considered load cases. For the cold and hot leg nozzle detailed linear-elastic and elasticplastic Finite Element Analyses (FEA) are performed to verify the integrity of the RPV. (orig.)

  15. Constructivist assessment proposal a case study in a technical and industrial school environment

    Directory of Open Access Journals (Sweden)

    Carol Yohana Suescún Pinilla

    2012-11-01

    Full Text Available This article is part of the ongoing research “Constructivist AssessmentProposal” held at Institución Educativa Técnica Integral in Sogamoso. It isaimed at identifying why the assessment traditional approach is still beingapplied. Besides, it pretends to redefine new assessment practices in order toenhance students’ participation, speech and creativity. Likewise, it tends tomake teachers be aware of alternative assessment ways more relevant withthe education needs and demands. It is based on the case study researchapproach and developed in three stages: problematic description andcontextualization, analysis and comprehension of the assessment used bythe teacher in a technical and industrial setting and improvement alternativeproposals based on the problematic situation.

  16. Questioning western assessment of trauma among Tibetan torture survivors. A quantitative assessment study with comments from Buddhist Lamas

    DEFF Research Database (Denmark)

    Elsass, Peter; Carlsson, Jessica; Jespersen, Kristian;

    2009-01-01

    did not have an influence on the level of distress. After the assessment study, eight Tibetan lamas were interviewed about their views on our methods and results. They questioned the validity of our western rating scales and explained that our results might be influenced by the Tibetan culture, which...... Symptom Checklist 25 (HSCL-25). Even though significant correlations between the amount of the measures of organized violence and neuropsychological and psychological distress were found in our data, the division of the material into different subgroups according to e.g. religious and non-religious groups...... among other things can be characterized as having a view and articulation of suffering much more complex than the units of our study's rating scales....

  17. The Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals (BEES-C) Instrument for Assessing Study Quality

    Science.gov (United States)

    Environmental epidemiology studies can be an effective means to assess impacts on human health from exposure to environmental stressors. Exposure scenarios are often extremely complex and proper assessment is critical for interpreting epidemiological study results. Biomarkers are...

  18. Evaluation of a new clinical performance assessment tool : A reliability study

    Directory of Open Access Journals (Sweden)

    C. Joseph

    2012-12-01

    Full Text Available Clinical practice is an essential requirement of any graduatephysiotherapy programme. For this purpose, valid and reliable assessment toolsare paramount for the measurement of key competencies in the real-worldsetting. This study aims to determine the internal consistency and inter-raterreliability of a newly developed and validated clinical performance assessmentform. A cross-sectional quantitative research design was used, which includedpaired evaluations of 32 (17 treatment and 15 assessment student examinationsperformed by two independent clinical educators. Chronbachs alpha was computedto assess internal consistency and intraclass correlation coefficient (ICC’s withconfidence intervals of 95% were computed to determine the percentage agreement between paired examiners. Thedegree of internal consistency was substantial for all key performance areas of both examinations, except for timeand organisational management (0.21 and professionalism (0.42 in the treatment and evaluation examinationsrespectively. The overall internal consistency was 0.89 and 0.73 for both treatment and assessment examinations,indicating substantial agreement. With regard to agreement between raters, the ICC’s for the overall marks were0.90 and 0.97 for both treatment and assessment examinations. Clinical educators demonstrated a high level ofreliability in the assessment of students’ competence using the newly developed clinical performance assessment form.These findings greatly underscore the reliability of results obtained through observation of student examinations, andadd another tool to the basket of ensuring quality assurance in physiotherapy clinical practice assessment.

  19. A study on assessment methodology of surveillance test interval and allowed outage time

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Chang Hyun; You, Young Woo; Cho, Jae Seon; Huh, Chang Wook; Kim, Do Hyoung; Kim, Ju Youl; Kim, Yoon Ik; Yang, Hui Chang; Park, Kang Min [Seoul National Univ., Seoul (Korea, Republic of)

    1998-03-15

    The objectives of this study is the development of methodology by which assesses the optimization of Surveillance Test Internal(STI) and Allowed Outage Time(AOT) using PSA method that can supplement the current deterministic methods and the improvement of Korean nuclear power plant safety. In this study, the survey about the assessment methodologies, modelings and results performed by domestic and international researches are performed as the basic step before developing the assessment methodology of this study. The assessment methodology that supplement the revealed problems in many other studies is presented and the application of new methodology into the example system assures the feasibility of this method. The sensitivity analyses about the failure factors of the components are performed in the bases of the and AOT is quantified. And the reliability assessment methodology about the diesel generator is reviewed and applied to the PSA code. The qualitative assessment for the STI/AOR of RPS/ESFAS assured safety the most important system in the nuclear power plant are performed.

  20. Study of personality’s temperament and self-assessment of higher educational establishments’ students

    Directory of Open Access Journals (Sweden)

    Liashenko V.N.

    2016-04-01

    Full Text Available Purpose: analysis of temperament and self-assessment characteristics in higher educational establishment students. Material: in the research 1st and 2nd year students (n=30 participated. Questioning was used, with the help of which personality’s self assessment and temperament characteristics were estimated. Results: the study of students’ temperament structure showed low demand in mastering of objective world and strive for mental and physical labor. High indicator of social activity and interpersonal skills was registered. The following indicators of self-assessment were received: 15% of students had too low self-assessment, 50% of students have adequate self-assessment and 10% have excessively high self-assessment. Conclusions: quickness of psychic processes (tem and rhythm, impressiveness and emotional sensitivity are important features of temperament. Students demonstrated feeling of anxiety and worry in respect to their studying at university. Besides the have sensitivity to failures to non coincidence of the desired and the results. студентов. With it students have adequate self assessment.

  1. Interrogating the Generalizability of Portfolio Assessments of Beginning Teachers: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Pamela A. Moss

    2004-07-01

    Full Text Available This qualitative study is intended to illuminate factors that affect the generalizability of portfolio assessments of beginning teachers. By generalizability, we refer here to the extent to which the portfolio assessment supports generalizations from the particular evidence reflected in the portfolio to the conception of competent teaching reflected in the standards on which the assessment is based. Or, more practically, “The key question is, ‘How likely is it that this finding would be reversed or substantially altered if a second, independent assessment of the same kind were made?’” (Cronbach, Linn, Brennan, and Haertel, 1997, p. 1. In addressing this question, we draw on two kinds of evidence that are rarely available: comparisons of two different portfolios completed by the same teacher in the same year and comparisons between a portfolio and a multi-day case study (observation and interview completed shortly after portfolio submission intended to parallel the evidence called for in the portfolio assessment. Our formative goal is to illuminate issues that assessment developers and users can take into account in designing assessment systems and appropriately limiting score interpretations.

  2. Varfarin in the complex treatment of antiphospholipid syndrome: preliminary results

    Directory of Open Access Journals (Sweden)

    T M Reshetnyak

    2003-01-01

    Full Text Available Objective. To assess efficacy and tolerance of varfarin in prophylaxis and therapy of thrombotic complications in patients with antiphospholipid syndrome (APS. Methods. 20 pts with APS (5 male and 15 female received varfarin during a year. 8 of them had primary APS (PAPS and 12 -systemic lupus erythematosus with APS (SLE+APS. 2 other pts (I with SLE+APS and I with PAPS received varfarin during the last 4 years. Nobody from 9 pts with PAPS received corticosteroids (CS. In SLE+APS pts CS dose varied from 4 to 20 mg/day and was not increased during follow up. During the study prothrombine time (PT was examined with thromboplastin ( manufactured by Renam having international sensitivity index 1,2 and international normalization relation (INR. Depending on treatment scheme APS pts were divided into 3 groups. Group 1 included 8 pts with INR<2,0, Group 2-7 with INR >3,0, group 3 - 7 pts with INR<2,0 receiving as additional treatment thrombo ASS 100 mg/day and vasonit from 600 to 1200 mg/day. Results. Two pts with INR = 1,8 had thrombosis recurrence (due to leg thrombophlebitis. There were no recurrences in other groups. 2 from 22 pts had "large" bleedings. "Small" bleedings episodes were noted in 7 from 22 pts. Largely that were subcutaneous bleedings (in 4 pts no more than 5 cm of size. Two pts receiving varfarin with INR 1,8 and 2,4 had renal colic. Conclusion. Our preliminary results prove the necessity of inclusion of varfarin in the treatment of pts with APS and thrombosis but intensive anticoagulant effect is not always desired.

  3. A study on the reliability and risk assessment of nuclear power plants

    International Nuclear Information System (INIS)

    The final objective of the present study is to establish the foundations of both performing statistical analyses of various failures and potential accidents in nuclear power plants and assessing probabilistic safety. In order to achive the objective, we have chosen the review of the state of the arts in the related methodologies and the establishment of reliability analysis method as study areas in this year. The works performed are summalized here. First, the brief reviews of the present status on the Probabilistic Risk Assessment and the development of quantiative safety goal in the Unite States were completed. It has been identified that the Probabilistic Risk Assessment techniques will take important role in nuclear safety assessment as a supporting tool in coming years. In order to establish reliability analysis methodology, a computer code for updating plant specific reliability data has been developed as a part of this project. A reliability analysis system has been estabished and used to analyize the axiliary feedwater system. (Author)

  4. Chronic hepatitis C--assessment in civil law: a case study.

    Science.gov (United States)

    Santos, Bruno Miguel; Sousa, Paula; Mena, Filomena; Costa, Graça Santos; Corte-Real, Francisco; Vieira, Duarte Nuno

    2010-02-01

    This article describes the case of a 58-year-old man who asked for an assessment of physical damage of a civil nature, having been diagnosed with chronic hepatitis C for which he blamed a blood transfusion, supposedly contaminated with hepatitis C virus (HCV). After studying the documentary information, a number of presuppositions were drawn up with a view to determining the causal nexus, but this could not be proved. The assessment of situations like this is not common in civil law. This article is intended to add to the body of information on the forensic assessment of similar cases. PMID:20129431

  5. Teachers’ Beliefs about Young EFL Learners’ Self-assessment: a Case Study of Macedonia

    OpenAIRE

    /Anžela Nikolovska

    2015-01-01

    The paper explores Macedonian primary EFL teachers’ attitudes, beliefs and practices regarding self-assessment of young learners (10-12 year-olds). The study surveyed primary EFL teachers (n=30) who teach English to 5th and 6th graders. The results indicated that vocabulary, grammar and reading were more often the focus of self-assessment tasks than the other areas of language learning. This, along with the finding that the receptive language skills were more frequently self-assessed than t...

  6. THE SELF-ASSESSMENT PROCESS AND IMPACTS ON PERFORMANCE: A CASE STUDY

    Directory of Open Access Journals (Sweden)

    Juan José Tarí

    2012-12-01

    Full Text Available The purpose of this paper is to analyze the effectiveness of the European Foundation for Quality Management model self-assessment process and its effects on performance in a private manufacturing firm. A case study is used, considering the analysis of primary and secondary data. This paper explains the self-assessment process using a workshop approach, and identifies benefits, difficulties and success factors. It also shows that self-assessment has partly improved performance and the attitudes and behaviour of management and employees, reinforcing the firm’s competitiveness. The contribution of this paper is to provide lessons for managers of other organisations to learn from.

  7. Evaluation of the American Study 'Viability Assessment of a Repository at Yucca Mountain

    International Nuclear Information System (INIS)

    On behalf of the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU), GRS Cologne studies and evaluates methods used in Performance Assessments of other countries within the framework of long-term safety assessments for geological radioactive waste repositories in order to support the development of this subject in Germany. In this context the following report evaluates the methods of the USA Final Disposal Management used in the U.S.-report ''Viability Assessment of a Repository at Yucca Mountain.'' (orig.)

  8. Study on wave energy resource assessing method based on altimeter data—A case study in Northwest Pacific

    Institute of Scientific and Technical Information of China (English)

    WAN Yong; ZHANG Jie; MENG Junmin; WANG Jing; DAI Yongshou

    2016-01-01

    Wave energy resource is a very important ocean renewable energy. A reliable assessment of wave energy resources must be performed before they can be exploited. Compared with wave model, altimeter can provide more accuratein situ observations for ocean wave which can be as a novel method for wave energy assessment. The advantage of altimeter data is to provide accurate significant wave height observations for wave. In order to develop characteristic and advantage of altimeter data and apply altimeter data to wave energy assessment, in this study, we established an assessing method for wave energy in local sea area which is dedicated to altimeter data. This method includes three parts including data selection and processing, establishment of evaluation indexes system and criterion of regional division. Then a case study of Northwest Pacific was performed to discuss specific application for this method. The results show that assessing method in this paper can assess reserves and temporal and spatial distribution effectively and provide scientific references for the siting of wave power plants and the design of wave energy convertors.

  9. Is objective and accurate cognitive assessment across the menstrual cycle possible? A feasibility study

    OpenAIRE

    Farrar, Diane; Neill, Jo; Scally, Andy; Tuffnell, Derek; Marshall, Kay

    2015-01-01

    Objectives: Variation in plasma hormone levels influences the neurobiology of brain regions involved in cognition and emotion processing. Fluctuations in hormone levels across the menstrual cycle could therefore alter cognitive performance and wellbeing; reports have provided conflicting results, however. The aim of this study was to assess whether objective assessment of cognitive performance and self-reported wellbeing during the follicular and luteal phases of the menstrual cycle is feasib...

  10. PERFORMANCE ASSESSMENT OF PRODUCT DEVELOPMENT PROCESS IN A BUS COMPANY: A CASE STUDY

    OpenAIRE

    Tiago Ribeiro de Araújo; Fernanda Cristina Pierre

    2014-01-01

    This article aims to examine the application of a method for assessing the performance of the product development process (PDP) through the assessment of managerial skills in a bus body industry. A case study was carried out and a PDP method was applied through a questionnaire addressing the PDP management skills according to Dechamps and Nayak (1997) model and validated by Silva (2001) in a bus body company which showed all the features available in the literature on industria...

  11. LIFE CYCLE ASSESSMENT FOR OIL PALM BASED PLYWOOD: A GATE-TO-GATE CASE STUDY

    OpenAIRE

    M. Shamim Ahmad; Vijaya Subramaniam; Halimah Mohammad; Anis Mokhtar; Ismail, B. S.

    2014-01-01

    Life Cycle Assessment (LCA) is an important tool for identifying potential environmental impacts associated with the production of palm based plywood. This study is to make available the life cycle inventory for gate-to-gate data so that the environmental impact posed by oil palm based plywood production can be assessed. Conducting an LCA on the palm based plywood that are derived from the wastes of the oil palm industry is a first step towards performing green environmental product. Therefor...

  12. Quantitative Assessment of Airborne Exposures Generated during Common Cleaning Tasks: A Pilot Study

    OpenAIRE

    Perry Melissa J; Quinn Margaret M; Bello Anila; Milton Donald K

    2010-01-01

    Abstract Background A growing body of epidemiologic evidence suggests an association between exposure to cleaning products with asthma and other respiratory disorders. Thus far, these studies have conducted only limited quantitative exposure assessments. Exposures from cleaning products are difficult to measure because they are complex mixtures of chemicals with a range of physicochemical properties, thus requiring multiple measurement techniques. We conducted a pilot exposure assessment stud...

  13. Validity, Reliability and Standardization Study of the Language Assessment Test for Aphasia

    OpenAIRE

    Bülent Toğram; İlknur Maviş

    2012-01-01

    OBJECTIVE: Aphasia assessment is the first step towards a well- founded language therapy. Language tests need to consider cultural as well as typological linguistic aspects of a given language. This study was designed to determine the standardization, validity and reliability of Language Assessment Test for Aphasia, which consists of eight subtests including spontaneous speech and language, auditory comprehension, repetition, naming, reading, grammar, speech acts, and writing. METHODS: The...

  14. The importance of landscape attributes in biodiversity assessment. The Évora case study.

    OpenAIRE

    Quinta-Nova, L.C.; Batista, T.

    2001-01-01

    The study of wildlife communities to assess the landscape value is crucial in Landscape Ecology in order to develop bidiversity management strategies in rural landscapes and to assist land managers with their decision making processes. This poster reports the results achieved assessing biodiversity using landscape structural indicators. The main objective was to identify the landscape measures having a greater influence on the presence of avian communities in agrosystems located around Évora ...

  15. A Case Study in Support of Multiple Post Mortem Assessments (Invited Paper)

    OpenAIRE

    Jill Pable; Kenan Fishburne

    2015-01-01

    Creative projects in various fields are often subjected to afterthe- fact 'post-mortem' assessments to better understand their successes and failures. Names for these include project retrospectives or post occupancy evaluations (POEs) depending on their field of origin. This case study from the architecture field will show the utility of engaging in multiple rounds of post-mortem activities in order to assess the solution from multiple stakeholder perspectives and in doing so, more fully reco...

  16. Can students assess themselves and their peers? : a five year study

    OpenAIRE

    Nortcliffe, Anne

    2012-01-01

    This paper highlights the results and conclusions drawn from five year study of embedding formative peer feedback and self and peer assessment in a in a Web Programming module. As an academic, assessment and feedback of a student’s assignment submission offers only one opinion on the work which can limit the student learning experience, whilst peer formative feedback offers the opportunity to provide a greater number of voices expressing their view on a submission. Could this be a solution...

  17. Assessment of possible airborne impact from risk sites: methodology for probabilistic atmospheric studies

    OpenAIRE

    A. A. Baklanov; A. G. Mahura

    2004-01-01

    The main purpose of this study is to develop a methodology for a multidisciplinary nuclear risk and vulnerability assessment, and to test this methodology through estimation of a nuclear risk to population in the Northern European countries in case of a severe accident at the nuclear risk sites. For assessment of the probabilistic risk and vulnerability, a combination of social-geophysical factors and probabilities are considered. The main focus of this paper is the des...

  18. Assessment of possible airborne impact from risk sites: methodology for probabilistic atmospheric studies

    OpenAIRE

    A. A. Baklanov; A. G. Mahura

    2004-01-01

    The main purpose of this study is to develop a methodology for a multidisciplinary nuclear risk and vulnerability assessment, and to test this methodology through estimation of a nuclear risk to population in the Northern European countries in case of a severe accident at the nuclear risk sites. For assessment of the probabilistic risk and vulnerability, a combination of social-geophysical factors and probabilities are considered. The main focus of this paper is the description of methodolog...

  19. Mobile Phone Assessment in Egocentric Networks: A Pilot Study on Gay Men and Their Peers

    OpenAIRE

    Comulada, WS

    2014-01-01

    Mobile phone-based data collection encompasses the richness of social network research. Both individual-level and network-level measures can be recorded. For example, health-related behaviors can be reported via mobile assessment. Social interactions can be assessed by phone-log data. Yet the potential of mobile phone data collection has largely been untapped. This is especially true of egocentric studies in public health settings where mobile phones can enhance both data collection and inter...

  20. Mobile Phone Assessment in Egocentric Networks: A Pilot Study on Gay Men and Their Peers.

    OpenAIRE

    Comulada, WS

    2014-01-01

    Mobile phone-based data collection encompasses the richness of social network research. Both individual-level and network-level measures can be recorded. For example, health-related behaviors can be reported via mobile assessment. Social interactions can be assessed by phone-log data. Yet the potential of mobile phone data collection has largely been untapped. This is especially true of egocentric studies in public health settings where mobile phones can enhance both data collection and inter...

  1. Do expert assessments converge? An exploratory case study of evaluating and managing a blood supply risk

    OpenAIRE

    Arnold Emmy; Webert Kathryn; Heddle Nancy; Eyles John; McCurdy Bronwen

    2011-01-01

    Abstract Background Examining professional assessments of a blood product recall/withdrawal and its implications for risk and public health, the paper introduces ideas about perceptions of minimal risk and its management. It also describes the context of publicly funded blood transfusion in Canada and the withdrawal event that is the basis of this study. Methods Interviews with 45 experts from administration, medicine, blood supply, laboratory services and risk assessment took place using a m...

  2. Identifying Distinct Quitting Trajectories after an Unassisted Smoking Cessation Attempt: An Ecological Momentary Assessment Study

    OpenAIRE

    Bachmann, Monica S.; Znoj, Hansjörg; Brodbeck, Jeannette

    2012-01-01

    Objectives: This study aimed at identifying distinct quitting trajectories over 29 days after an unassisted smoking ces- sation attempt by ecological momentary assessment (EMA). In order to validate these trajectories we tested if they predict smoking frequency up to six months later. Methods: EMA via mobile phones was used to collect real time data on smoking (yes/no) after an unassisted quit attempt over 29 days. Smoking frequency one, three and six months after the quit attempt was assesse...

  3. Assessment of Osstell ISQ's reliability for implant stability measurement: a cross-sectional clinical study

    OpenAIRE

    Herrero Climent, Mariano; Santos García, Rocío; Jaramillo Santos, Reyes; Romero Ruiz, Manuel María; Fernández Palacín, Ana; Lázaro Calvo, Pedro; Bullón, Pedro; Ríos Santos, José Vicente

    2013-01-01

    Resonance frequency analysis (RFA) allows assess implant stability by measuring implant oscillation frequency on the bone. RFA is an objective and non-invasive method for implant stability measurement, although scarce evidence has been provided so far on its reliability. Objectives: Assess the Osstell ISQ system’s reliability (i.e., its measurement reproducibility and repeatability) by means of the intraclass correlation coefficient (ICC) as statistical method. Study Desing: Implants stabilit...

  4. Web-based Peer Assessment: A Case Study with Civil Engineering Students

    OpenAIRE

    Gonçalo Cruz; Caroline Dominguez; Ana Maia; Daniela Pedrosa; Gordon Grams

    2013-01-01

    Peer-assessed online collaborative writing is of growing importance for higher education. Based on the quantitative and qualitative analysis of collected data, this work presents the results of a case study in a graduate civil engineering course at the University of Trás-os-Montes e Alto Douro, Vila Real, Portugal. After an overall presentation of the learning activity, it examines students’ attitudes towards web-based peer assessment and identifies which factors are rela...

  5. Hegemonic Masculinity in Sport Education: Case Studies of Experienced In-Service Teachers with Teaching Orientations

    Science.gov (United States)

    Chen, YuChun; Curtner-Smith, Matthew

    2013-01-01

    Research has revealed that while pre-service teachers (PTs) with coaching orientations reinforce sexism and masculine bias, those with teaching orientations combat and reject it. The purpose of this study was to examine four sport education (SE) seasons taught by two experienced in-service teachers for the presence or absence of sexism and…

  6. Risk of bias versus quality assessment of randomised controlled trials: cross sectional study

    Science.gov (United States)

    Ospina, Maria; Liang, Yuanyuan; Dryden, Donna M; Hooton, Nicola; Krebs Seida, Jennifer; Klassen, Terry P

    2009-01-01

    Objectives To evaluate the risk of bias tool, introduced by the Cochrane Collaboration for assessing the internal validity of randomised trials, for inter-rater agreement, concurrent validity compared with the Jadad scale and Schulz approach to allocation concealment, and the relation between risk of bias and effect estimates. Design Cross sectional study. Study sample 163 trials in children. Main outcome measures Inter-rater agreement between reviewers assessing trials using the risk of bias tool (weighted κ), time to apply the risk of bias tool compared with other approaches to quality assessment (paired t test), degree of correlation for overall risk compared with overall quality scores (Kendall’s τ statistic), and magnitude of effect estimates for studies classified as being at high, unclear, or low risk of bias (metaregression). Results Inter-rater agreement on individual domains of the risk of bias tool ranged from slight (κ=0.13) to substantial (κ=0.74). The mean time to complete the risk of bias tool was significantly longer than for the Jadad scale and Schulz approach, individually or combined (8.8 minutes (SD 2.2) per study v 2.0 (SD 0.8), P<0.001). There was low correlation between risk of bias overall compared with the Jadad scores (P=0.395) and Schulz approach (P=0.064). Effect sizes differed between studies assessed as being at high or unclear risk of bias (0.52) compared with those at low risk (0.23). Conclusions Inter-rater agreement varied across domains of the risk of bias tool. Generally, agreement was poorer for those items that required more judgment. There was low correlation between assessments of overall risk of bias and two common approaches to quality assessment: the Jadad scale and Schulz approach to allocation concealment. Overall risk of bias as assessed by the risk of bias tool differentiated effect estimates, with more conservative estimates for studies at low risk. PMID:19841007

  7. Sudbury soils study : human health and ecological risk assessment : a case study in science, process and perception

    International Nuclear Information System (INIS)

    This presentation discussed the public relations and public opinion strategies used as part of a soils study conducted to assess the risk of mining activities in the Sudbury region to human health and the environment. The human health risk assessment (HHRA) study was conducted and administered by a multi-stakeholder technical committee attended by the public. The study was comprised of extensive soil collection and analysis; a review of historical soils data; and extensive human health and ecological risk assessments. Extensive sampling was also conducted on air, dust, and locally-produced foods. A public advisory committee was formed to disseminate scientific information to the community. Scientific data obtained in the study were reviewed by experts in various fields. Results of the study were also peer-reviewed by an independent expert review panel comprised of leading specialists in human health, toxicology, speciation, and risk assessment. The study showed that the identified risks were over-estimated in the interest of protecting human health. It was concluded that the HHRA's findings were generally accepted by the public. tabs., figs

  8. Does high dose rate irradiation of obstructive intrabronchial malignancy justify the high cost? A study of 83 patients

    International Nuclear Information System (INIS)

    Purpose: Over a 6 year period, 1989 through 1994, 83 patients (pts) (76 pts with primary lung carcinoma (ca) and 7 pts with a solitary metastic lesion to the lung) and with bronchoscopically identified obstructive tumor, causing symptoms (sx's) of cough, hemoptysis and/or shortness of breath (SOB) were treated with high dose rate (HDR) Ir-192 intrabronchial irradiation (XRT), and are the basis of this study. The purpose of this retrospective study is to determine the survival and relief of sx's, compare our results to those in the classic radiation oncology lung ca literature, and determine if the improvement is sufficient to justify the high cost of adding HDR XRT to standard external beam XRT. Methods and Materials: 44 pts presented with de novo disease and initially received a course of external beam XRT (5000 - 6000 cGy, standard fractionation) followed by 3 HDR tx's of 800 cGy per treatment (tx) calculated at one cm depth, separated by one week intervals, for a total HDR dose of 2400 cGy. 39 pts presented with locally recurrent disease following prior tx with external beam XRT, and they received 3 HDR tx's, 1000 cGy per tx, one cm from the center of the catheter, separated by one week intervals, for a total dose to the tumor of 3000 cGy. All patients presented with one or more obstructive sx's. Relief of these sx's were determined at last follow-up (FU) or until death. All patients have been followed for a minimum of 6 months (mos). Results: Our results show overall median survivals of 13 mos since initial diagnosis and 6 mos since treatment. In light of these results, we attempted to determine a subgroup of patients who might have a statistically significant increase in survival. The subgroups we analyzed were 1) pts with recurrent disease, 2) those treated in later years of the study, surmising we were more selective as our experience increased, 3) squamous histology with its natural history to remain localized, and 4) younger patients, age below 50. Our

  9. Field procedures in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

    OpenAIRE

    Heeringa, Steven G.; Gebler, Nancy; Colpe, Lisa J.; Carol S Fullerton; Hwang, Irving; Ronald C. Kessler; Naifeh, James A.; Nock, Matthew K.; Sampson, Nancy A; Schoenbaum, Michael; Zaslavsky, Alan M.; Stein, Murray B.; Ursano, Robert J.

    2013-01-01

    The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) is a multi-component epidemiological and neurobiological study of unprecedented size and complexity designed to generate actionable evidence-based recommendations to reduce U.S. Army suicides and increase basic knowledge about determinants of suicidality by carrying out coordinated component studies. A number of major logistical challenges were faced in implementing these studies. The current report presents an overv...

  10. Validation of the automatic image analyser to assess retinal vessel calibre (ALTAIR): a prospective study protocol

    OpenAIRE

    Garcia-Ortiz, Luis; Gómez-Marcos, Manuel A.; Recio-Rodríguez, Jose I; Maderuelo-Fernández, Jose A; Chamoso-Santos, Pablo; Rodríguez-González, Sara; de Paz-Santana, Juan F; Merchan-Cifuentes, Miguel A; Corchado-Rodríguez, Juan M

    2014-01-01

    Introduction The fundus examination is a non-invasive evaluation of the microcirculation of the retina. The aim of the present study is to develop and validate (reliability and validity) the ALTAIR software platform (Automatic image analyser to assess retinal vessel calibre) in order to analyse its utility in different clinical environments. Methods and analysis A cross-sectional study in the first phase and a prospective observational study in the second with 4 years of follow-up. The study ...

  11. Systematic review of foodborne burden of disease studies: Quality assessment of data and methodology

    OpenAIRE

    Haagsma, Juanita; Polinder, Suzanne; Stein, Claudia; Havelaar, Arie

    2013-01-01

    textabstractBurden of disease (BoD) studies aim to identify the public health impact of different health problems and risk factors. To assess BoD, detailed knowledge is needed on epidemiology, disability and mortality in the population under study. This is particularly challenging for foodborne disease, because of the multitude of causative agents and their health effects. The purpose of this study is to systematically review the methodology of foodborne BoD studies. Three key questions were ...

  12. Design of the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

    OpenAIRE

    Ronald C. Kessler; Colpe, Lisa J.; Fullerton, Carol S.; Gebler, Nancy; Naifeh, James A.; Nock, Matthew K.; Sampson, Nancy A.; Schoenbaum, Michael; Zaslavsky, Alan M.; Stein, Murray B; Ursano, Robert J.; Heeringa, Steven G.

    2013-01-01

    The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) is a multi-component epidemiological and neurobiological study designed to generate actionable evidence-based recommendations to reduce U.S. Army suicides and increase basic knowledge about the determinants of suicidality. This report presents an overview of the designs of the six component Army STARRS studies. These include: an integrated study of historical administrative data systems (HADS) designed to provide dat...

  13. Intentional Exposure Studies of Environmental Agents on Human Subjects: Assessing Benefits and Risks

    OpenAIRE

    Resnik, David B.

    2007-01-01

    In this article, I assess the benefits and risks of studies that intentionally expose research subjects to environmental agents. I describe these types of studies, identify their benefits and risks, compare these studies to other research methods that can be used to investigate the relationship between environmental exposures and disease, and discuss some issues related to research design and risk minimization. I argue that the benefits of intentional environmental exposure studies outweigh t...

  14. Understanding Perspectives of English Language Learning and Assessment Practices: A Mixed-Method Embedded Study

    Science.gov (United States)

    Bailey, Angela Christine

    2013-01-01

    This study contributed to the continuing dialogue of quality language programs and student outcomes for classroom language learning and assessments within the standardized testing era to language learning programs within Colombia. The particular purpose of this one-phase, embedded, mixed-method study examined students' and teachers' beliefs about…

  15. 75 FR 1793 - Study Team for the Los Alamos Historical Document Retrieval and Assessment (LAHDRA) Project

    Science.gov (United States)

    2010-01-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Study Team for the Los Alamos Historical...: Public Meeting of the Study Team for the Los Alamos Historical Document Retrieval and Assessment...

  16. Assessment of mastication in healthy children and children with cerebral palsy: a validity and consistency study

    NARCIS (Netherlands)

    Remijn, L.; Speyer, R.; Groen, B.E.; Holtus, P.C.; Limbeek, J. van; Nijhuis-Van der Sanden, M.W.G.

    2013-01-01

    The aim of this study was to develop the Mastication Observation and Evaluation instrument for observing and assessing the chewing ability of children eating solid and lumpy foods. This study describes the process of item definition and item selection and reports the content validity, reproducibilit

  17. Do Plot Scale Studies Yield Useful Data When Assessing Field Scale Practices?

    Science.gov (United States)

    Plot scale data has been used to develop models used to assess field and watershed scale nutrient losses. The objective of this study was to determine if phosphorus (P) loss results from plot scale rainfall simulation studies are “directionally correct” when compared to field scale P losses. Two fie...

  18. Assessing Honor Code Effectiveness: Results of a Multipronged Approach from a Five Year Study

    Science.gov (United States)

    Sledge, Sally; Pringle, Pam

    2010-01-01

    This paper describes an ongoing study at a small public university to assess student, faculty and alumni perceptions of academic integrity and business ethics. The phases of the research are detailed for application or replication by other institutions of higher education. The study involves anonymous surveys and academic integrity-based…

  19. Assessing progression of clinical reasoning through virtual patients: An exploratory study.

    Science.gov (United States)

    Forsberg, Elenita; Ziegert, Kristina; Hult, Håkan; Fors, Uno

    2016-01-01

    To avoid test-driven learning, there have been discussions regarding the use of more formative assessments in health care education to promote students' deep learning. Feedback is important in formative assessment, but many students ignore it; therefore, interventions should be introduced which stimulate them to reflect on the new knowledge. The aim for this study was to explore if Virtual Patient (VP)-based formative assessments, in connection with self-evaluations, had an impact on postgraduate pediatric nursing students' development of clinical reasoning abilities. Students' self-evaluations served as the basis for measuring progress. Data was analysed using deductive content analysis. The findings showed a clear progression of the clinical reasoning ability of the students. After the first assessment, the students described feelings of uncertainty and that their knowledge gaps were exposed. At the mid-course assessment the awareness of improved clinical reasoning was obvious and the students were more certain of knowing how to solve the VP cases. In the final assessment, self-efficacy was expressed. VP-based assessments, in connection with self-evaluations, early in the education resulted in a gain of students' own identification of the concept of clinical reasoning, awareness of what to focus on during clinical practice and visualised expected clinical competence. PMID:26482401

  20. LEARNING ASSESSMENT: A STUDY BASED ON THE PERCEPTIONS OF UNDERGRADUATE MANAGEMENT STUDENTS

    Directory of Open Access Journals (Sweden)

    Marianny Jessica de Brito Silva

    2015-06-01

    Full Text Available This paper aimed to identify the perception of undergraduate Management course students from the Federal University of Pernambuco (UFPE, Agreste Campus, about their professors’ assessment methods. A quantitative approach was employed through a questionnaire conducted on a research sample of 155 students. The data collected and analyzed revealed that the students in question pointed out didactic and bureaucratic functions as the reasons for undertaking assessments and recognized their importance only for students, as an indication of their performance. Most students stated that their feelings about the assessment processes vary according to their time of study and empathy for the discipline, and that the teaching-assessment ratio is generally positive. Assessment feedback was common practice for the sample, but there was a lack of diversity of assessment tools and those used clash with the ones they desired. In conclusion, according to the students’ perception, it is possible to develop multiple thoughts about the assessment process, driving improvements in educational practices and the formation and training of university professors.

  1. Vulnerability and Risk Assessment of Extreme Weather Events- A Case Study from Bangladesh

    Science.gov (United States)

    Fakhruddin, S.; Mukand, M. S.; Kawasaki, A.; Webster, P. J.

    2013-12-01

    Assessment of hazard, vulnerability and risk of extreme weather are essential in order to inform and implement appropriate adaptation/prevention/mitigation strategies. Due to complex nature and uncertainties in future climate change predictions, it is not feasible to detail assessment of vulnerability at detailed scales for potential hazard and risk. Though different approaches and methods exist for running hazard, vulnerability and risk assessment, but still difficult to address all physical science, engineering, and social science research. In this study, we try to discuss on the human vulnerability and risk assessment approaches, tools and techniques of natural hazard due to extreme weather events (i.e. floods, cyclone). We analyzed different approaches and methods of vulnerability and risk assessment for flood hazard based on medium (1-10 days) and seasonal (1-3 months) ensembles probabilistic forecasts. The multiple weather ensembles (EPS) forecasts of European Center for Medium Range Forecasts (ECMWF) and downscaled Community Climate System Model Version 3 (CCSM3) forecasts data were used to set up hydrological model. Due to high uncertainty in forecasts information, results summarized that data and inherent low resolutions of the information are major constrains for details comprehensive assessment. Risk and vulnerability rises to be based on multi-scale and cross-scale analyses, considering resilience dimensions and provide innovative tools for understanding, assessing and communicating probabilistic information to the users for decision making. The sectoral responses were developed with possible impacts scenarios based on uncertainty ranges to choose the most robust solution.

  2. Establishing Normative Values for the Barnett Balance Assessment Tool: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Monica L. Cercone MSOTS

    2014-04-01

    Full Text Available The purpose of this study was to establish normative data for the Barnett Balance Assessment (BBA for individuals ages 18-70+ years. The BBA is a newly developed assessment tool that may address limitations present in other assessments currently used to detect balance deficits. The BBA was administered to 141 participants who had no history of medical issues that could impact balance. A review of the normative data collected indicated little variation in total assessment scores in the age categories of 18-29, 30-39, and 40-49, due to the presence of a ceiling effect. Variations existed in scores among participants in the remaining age categories (50-59, 60-69, and 70+. These findings may imply that the BBA has its greatest discriminative power in assessing individuals with impaired balance, and/or that the BBA is not sensitive enough to detect differences in individuals with mild balance impairments. The researchers suggest future studies be conducted with the BBA to establish norms with populations with known orthopedic or neurological conditions that may impair balance. Results of these studies could then be compared with the baseline data gathered in this study to determine the BBA’s usefulness in detecting balance impairments with clinical populations.

  3. The clinical impact of perfusion scintigraphy with dipyridamole

    International Nuclear Information System (INIS)

    In order to assess their clinical impact, the authors analyzed perfusion scintigrams (PS) with dipyridamole (D) and the resultant clinical management in 41 consecutive patients (PTS). Population mean age was 67, with 22 males and represented 14% of those having PS. Fifteen PTS had rest chest pain of unknown cause and 26 PTS had pain typical or suggestive of angina but couldn't undergo dynamic stress due to claudication, arthritis, amputation, stroke, recent surgery or other disability. Four PTS were studies for surgical clearance, 3 following angiography to assess coronary pathophysiology and 9 had prior negative or equivocal stress PS at suboptimal levels. Among 18 PTS with reversible scintigraphic abnormalities, 10 underwent subsequent catheterization, with successful CABG in 7, PTCA in 1, aggressive medical treatment of ischemia in 11, and 2 had noncoronary surgery delayed. One PT with associated extensive fixed abnormalities underwent CABG and died late in heart failure. Among 23 PTS without significant scintigraphic reversibility, 8 with normal studies were discharged, 3 went on to uncomplicated noncardiac surgery and 11 PTS, 9 with dilated cardiomyopathy, were managed without therapeutic change. D infusion was uncomplicated and related findings on PS correlated well with coronary angiography, where available in 19 of 20 PTS. PS with D: 1) is safe; 2) correlates closely with coronary anatomy; and 3) adds unique, important pathophysiologic information to clinical evaluation and impacts strongly on the management of a large number of PTS with known or suspected coronary disease

  4. Incorporating formative assessment and science content into elementary science methods---A case study

    Science.gov (United States)

    Brower, Derek John

    Just as elementary students enter the science classroom with prior knowledge and experiences, so do preservice elementary teachers who enter the science methods classroom. Elementary science methods instructors recognize the challenges associated with preparing teachers for the science classroom. Two of these challenges include overcoming limited science content understanding and a low science teaching efficacy. Based upon research in science misconceptions, conceptual change theory, formative assessment, and science teaching efficacy, this design experiment explored the use of formative assessment in an authentic learning environment to address some of these challenges. As a case study, the goal was to identify two specific topics in science which the preservice teachers did not understand and to model consistent use of formative assessment to guide instruction in those science topics for six weeks. The research questions for this study sought to explore the design of the class while also exploring students' understanding of the science content and their understanding of formative assessment. One specific question was whether the formative data could differentiate between deeply held student misconceptions in science and incomplete science understanding. In addition, data was collected to measure changes in science teaching efficacy as well as preservice teachers' desire to use formative assessment in their own future classrooms. Based upon student interviews and a final content quiz, the participants in this study did show improved science content understanding in the areas of plant food/energy and plate tectonics. The course design implemented a variety of formative assessment tools including formative assessment probes, student science notebooks, student concept maps, a non-graded quiz, and more. The STEBI-B survey identified improved science teaching efficacy among the participants. Student final essays indicated improved understanding of formative assessment

  5. Effect of continuous assessment on learning outcomes on two chemical engineering courses: case study

    Science.gov (United States)

    Tuunila, R.; Pulkkinen, M.

    2015-11-01

    In this paper, the effect of continuous assessment on the learning outcomes of two chemical engineering courses is studied over a several-year period. Average grades and passing percentages of courses after the final examination are reported and also student feedback on the courses is collected. The results indicate significantly better learning results after the adoption of continuous assessment in the courses. Also student feedback suggests higher quality in teaching after the adoption of more activating teaching methods which compel students to study effectively throughout the course.

  6. Recommendations by Cochrane Review Groups for assessment of the risk of bias in studies

    Directory of Open Access Journals (Sweden)

    Gøtzsche Peter C

    2008-04-01

    Full Text Available Abstract Background Assessing the risk of bias in individual studies in a systematic review can be done using individual components or by summarizing the study quality in an overall score. Methods We examined the instructions to authors of the 50 Cochrane Review Groups that focus on clinical interventions for recommendations on methodological quality assessment of studies. Results Forty-one of the review groups (82% recommended quality assessment using components and nine using a scale. All groups recommending components recommended to assess concealment of allocation, compared to only two of the groups recommending scales (P Conclusion We found that recommendations by some groups were not based on empirical evidence and many groups had no recommendations on how to use the quality assessment in reviews. We suggest that all Cochrane Review Groups refer to the Cochrane Handbook for Systematic Reviews of Interventions, which is evidence-based, in their instructions to authors and that their own guidelines are kept to a minimum and describe only how methodological topics that are specific to their fields should be handled.

  7. Contextual assessment of organisational culture - methodological development in two case studies

    International Nuclear Information System (INIS)

    Despite the acknowledged significance of organisational culture in the nuclear field, previous cultural studies have concentrated on purely safety related matters, or been only descriptive in nature. New kinds of methods, taking into account the overall objectives of the organisation, were needed to assess culture and develop its working practices appropriately. VTT developed the Contextual Assessment of Organisational Culture (CAOC) methodology during the FINNUS programme. The methodology utilises two concepts, organisational culture and core task. The core task can be defined as the core demands and content of work that the organisation has to accomplish in order to be effective. The core task concept is used in assessing the central dimensions of the organisation's culture. Organisational culture is defined as a solution the company has generated in order to fulfil the perceived demands of its core task. The CAOC-methodology was applied in two case studies, in the Radiation and Nuclear Safety Authority of Finland and in the maintenance unit of Loviisa NPP. The aim of the studies was not only to assess the given culture, but also to give the personnel new concepts and new tools for reflecting on their organisation, their jobs and on appropriate working practices. The CAOC-methodology contributes to the design and redesign of work in complex sociotechnical systems. It strives to enhance organisations' capability to assess their current working practices and the meanings attached to them and compare these to the actual demands of their basic mission and so change unadaptive practices. (orig.)

  8. What is Learned from Longitudinal Studies of Advertising and Youth Drinking and Smoking? A Critical Assessment

    Directory of Open Access Journals (Sweden)

    Jon P. Nelson

    2010-03-01

    Full Text Available This paper assesses the methodology employed in longitudinal studies of advertising and youth drinking and smoking behaviors. These studies often are given a causal interpretation in the psychology and public health literatures. Four issues are examined from the perspective of econometrics. First, specification and validation of empirical models. Second, empirical issues associated with measures of advertising receptivity and exposure. Third, potential endogeneity of receptivity and exposure variables. Fourth, sample selection bias in baseline and follow-up surveys. Longitudinal studies reviewed include 20 studies of youth drinking and 26 studies of youth smoking. Substantial shortcomings are found in the studies, which preclude a causal interpretation.

  9. Qualichem in vivo: A tool for assessing the quality of in vivo studies and its application for bisphenol A

    NARCIS (Netherlands)

    Maxim, Laura; Van Der Sluijs, Jeroen P.

    2014-01-01

    In regulatory toxicology, quality assessment of in vivo studies is a critical step for assessing chemical risks. It is crucial for preserving public health studies that are considered suitable for regulating chemicals are robust. Current procedures for conducting quality assessments in safety agenci

  10. Profiling postgraduate workplace-based assessment implementation in Ireland: a retrospective cohort study.

    Science.gov (United States)

    Barrett, Aileen; Galvin, Rose; Steinert, Yvonne; Scherpbier, Albert; O'Shaughnessy, Ann; Walsh, Gillian; Horgan, Mary

    2016-01-01

    In 2010, workplace-based assessment (WBA) was formally integrated as a method of formative trainee assessment into 29 basic and higher specialist medical training (BST/HST) programmes in six postgraduate training bodies in Ireland. The aim of this study is to explore how WBA is being implemented and to examine if WBA is being used formatively as originally intended. A retrospective cohort study was conducted and approved by the institution's Research Ethics Committee. A profile of WBA requirements was obtained from 29 training programme curricula. A data extraction tool was developed to extract anonymous data, including written feedback and timing of assessments, from Year 1 and 2 trainee ePortfolios in 2012-2013. Data were independently quality assessed and compared to the reference standard number of assessments mandated annually where relevant. All 29 training programmes mandated the inclusion of at least one case-based discussion (max = 5; range 1-5). All except two non-clinical programmes (93 %) required at least two mini-Clinical Evaluation Exercise assessments per year and Direct Observation of Procedural Skills assessments were mandated in 27 training programmes over the course of the programme. WBA data were extracted from 50 % of randomly selected BST ePortfolios in four programmes (n = 142) and 70 % of HST ePortfolios (n = 115) in 21 programmes registered for 2012-2013. Four programmes did not have an eligible trainee for that academic year. In total, 1142 WBAs were analysed. A total of 164 trainees (63.8 %) had completed at least one WBA. The average number of WBAs completed by HST trainees was 7.75 (SD 5.8; 95 % CI 6.5-8.9; range 1-34). BST trainees completed an average of 6.1 assessments (SD 9.3; 95 % CI 4.01-8.19; range 1-76). Feedback-of varied length and quality-was provided on 44.9 % of assessments. The majority of WBAs were completed in the second half of the year. There is significant heterogeneity with respect to the frequency and

  11. Indoor air assessment: A review of indoor-air-quality risk characterization studies

    International Nuclear Information System (INIS)

    Risk assessment methodologies provide a mechanism for incorporating scientific evidence and judgments into the risk management decision process. A risk characterization framework has been developed to provide a systematic approach for analysis and presentation of risk characterization study results. The framework was used as a tool to review published studies that provide quantitative risk estimates associated with exposure to indoor air pollutants. Comparisons of both the methods and the resulting risk estimates are presented. Critical assumptions concerning risk estimates and exposure estimates for each study are recorded on the framework. Fourteen risk characterization studies were reviewed include three studies for radon, six for environmental tobacco smoke, three for volatile organics, one for formaldehyde only, and one for asbestos. The quality and rigor of analysis varied greatly among the studies reviewed. Some of the studies clearly state that they are intended to be preliminary analyses or screening studies, others are reported as sensitivity analyses, and others are detailed risk assessments. Studies which are technically rigorous in some risk components (e.g., dose-response relationships) are often less rigorous in other components (e.g. exposure assessment)

  12. Southeast Regional Assessment Study: an assessment of the opportunities of solar electric power generation in the Southeastern United States

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-07-01

    The objective of this study was to identify and assess opportunities for demonstration and large scale deployment of solar electric facilities in the southeast region and to define the technical, economic, and institutional factors that can contribute to an accelerated use of solar energy for electric power generation. Graphs and tables are presented indicating the solar resource potential, siting opportunities, energy generation and use, and socioeconomic factors of the region by state. Solar electric technologies considered include both central station and dispersed solar electric generating facilities. Central stations studied include solar thermal electric, wind, photovoltaic, ocean thermal gradient, and biomass; dispersed facilities include solar thermal total energy systems, wind, and photovoltaic. The value of solar electric facilities is determined in terms of the value of conventional facilities and the use of conventional fuels which the solar facilities can replace. Suitable cost and risk sharing mechanisms to accelerate the commercialization of solar electric technologies in the Southeast are identified. The major regulatory and legal factors which could impact on the commercialization of solar facilities are reviewed. The most important factors which affect market penetration are reviewed, ways to accelerate the implementation of these technologies are identified, and market entry paths are identified. Conclusions and recommendations are presented. (WHK)

  13. 78 FR 22891 - Proposed Collection; 60-day Comment Request: Topic-based Studies for the Population Assessment of...

    Science.gov (United States)

    2013-04-17

    ... Studies for the Population Assessment of Tobacco and Health (PATH) Study SUMMARY: In compliance with the... Collection: Topic-based Studies for the Population Assessment of Tobacco and Health (PATH) Study, 0925-New... Collection: The PATH study will establish a population-based framework for the tracking of...

  14. A preliminary study on application of risk assessment to seismic risk management of nuclear fuel facilities

    International Nuclear Information System (INIS)

    Studies on risk-informed safety regulation and/or management of nuclear installations are being carried out world widely on the background of progress in development of probabilistic safety assessment (PSA) methodology and its application. The study on PSA methodology and application is on going at the Japan Atomic Energy Agency. A PSA methodology has been developed for MOX fuel fabrication facilities in this study. A preliminary study on application of risk assessment to examine seismic risk management of nuclear fuel facilities has been also carried out as one of those research activities. A simple approach of assessing risk has been investigated based on the analytical policy so called 'graded approach' in which detail of risk analysis can be changed corresponding with the level of potential risk of facilities. Following three issues have been studied with a sample case of uranium fuel fabrication facility. (1) Approach to application of Seismic PSA to examine reasonable practicable seismic risk management, (2) Assessing method of seismic induced accident scenarios and their consequence, (3) Applicable safety level to evaluate the effectiveness of risk management. (author)

  15. Web-based Peer Assessment: A Case Study with Civil Engineering Students

    Directory of Open Access Journals (Sweden)

    Gonçalo Cruz

    2013-02-01

    Full Text Available Peer-assessed online collaborative writing is of growing importance for higher education. Based on the quantitative and qualitative analysis of collected data, this work presents the results of a case study in a graduate civil engineering course at the University of Trás-os-Montes e Alto Douro, Vila Real, Portugal. After an overall presentation of the learning activity, it examines students’ attitudes towards web-based peer assessment and identifies which factors are related to students’ use and appreciation of feedback. In addition, an analysis of the type of feedback is presented in an attempt to evaluate students’  written communication skills. The results of this study provide indications on how to improve the design and implementation of future web-based peer assessment tasks and raise questions on the effectiveness of peer/teacher grading in the use of feedback.

  16. Assessment of modern methods of human factor reliability analysis in PSA studies

    International Nuclear Information System (INIS)

    The report is structured as follows: Classical terms and objects (Probabilistic safety assessment as a framework for human reliability assessment; Human failure within the PSA model; Basic types of operator failure modelled in a PSA study and analyzed by HRA methods; Qualitative analysis of human reliability; Quantitative analysis of human reliability used; Process of analysis of nuclear reactor operator reliability in a PSA study); New terms and objects (Analysis of dependences; Errors of omission; Errors of commission; Error forcing context); and Overview and brief assessment of human reliability analysis (Basic characteristics of the methods; Assets and drawbacks of the use of each of HRA method; History and prospects of the use of the methods). (P.A.)

  17. Biomass Assessment. Assessment of global biomass potentials and their links to food, water, biodiversity, energy demand and economy. Inventory and analysis of existing studies. Supporting document

    International Nuclear Information System (INIS)

    This supporting document contains the result from the inventory phase of the biomass assessment of global biomass potentials and their links to food, water, biodiversity, energy demand and economy. This study provides a comprehensive assessment of global biomass potential estimates, focusing on the various factors affecting these potentials, such as food supplies, water use, biodiversity, energy demands and agro-economics

  18. Water Footprint and Life Cycle Assessment as approaches to assess potential impacts of products on water consumption: Key learning points from pilot studies on tea and margarine

    NARCIS (Netherlands)

    Jefferies, D.; Muñoz, I.; Hodges, J.; King, V.J.; Aldaya, M.M.; Ercin, A.E.; Milá i Canals, L.; Hoekstra, A.Y.

    2012-01-01

    Water accounting and environmental impact assessment across the product's life cycle is gaining prominence. This paper presents two case studies of applying the Life Cycle Assessment (LCA) and Water Footprint (WF) approaches to tea and margarine. The WF, excluding grey water, of a carton of 50 g tea

  19. Scintigraphic assessment of salivary dysfunction after radiation therapy using CT simulation technique in patients with head and neck cancers

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jung Woo; Ryu, Jin Sook; Chang, Hye Sook; Lee, Hee Kyung [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of)

    1999-07-01

    Radiation therapy using CT simulation technique can provide shielding for normal tissue and significantly reduce radiation-induced xerostomia in head and neck cancer patient(pt)s. The aim of this study was to assess the salivary dysfunction after radiation therapy in pts with head and neck cancer and to evaluate the salivary shielding effect of CT simulation technique by salivary scintigraphy. Fifteen pts (mean age: 48{+-}15) who had been irradiated to head and neck for various malignancies (papillary thyroid cancer: 5, nasopharyngeal cancer: 4, lymphoma: 3, other: 4) underwent salivary scintigraphy with Tc-99m pertechnetate before and 4-6 months after radiation theraphy (mean interval: 158{+-}33 days). The mean neck radiation dose was 58{+-}11 cGy. Ten salivary glands (9 parotid glands, 1 submandibular gland) were shielded from radiation (less than 30 cGy of mean dose in 80% volume of gland). Using salivary scintigraphy, secretory function (uptake{sub 20}; glandular uptake at 20 minute/ background uptake) and excretory function (EF: %washout after stimulation of orange juice) of each glands were obtained. Fifty seven salivary glands were analyzed. In irradiated glands (n=47), the EF values of both parotid and submanidibular glands were significantly, decreased compared with before radiation (59.3{+-}26.4 vs 15.9{+-}28.4, 56.6{+-}22.9 vs 12.6{+-}21.9 respectively, p<0.005) and the uptake{sub 20} values of both parotid and submandibular glands were also significantly decreased after radiation (4.0{+-}1.8 vs2.4{+-}0.9, p<0.001, 5.3{+-}1.9 vs 4.2{+-}1.4, p<0.05). The uptake{sub 20} and EF values of shielded glands before and after radiation therapy showed no significant difference (3.9{+-}1.9 vs 3.9{+-}2.4, 56.97{+-}27.8 vs 55.9{+-}28.5, respectively). In radiation therapy of head and neck cancer, salivary dysfunction can be prevented using radiation shield by CT simulation technique. Salivary scintigraphy is a useful non-invasive tool for quantitative assessment of

  20. Scintigraphic assessment of salivary dysfunction after radiation therapy using CT simulation technique in patients with head and neck cancers

    International Nuclear Information System (INIS)

    Radiation therapy using CT simulation technique can provide shielding for normal tissue and significantly reduce radiation-induced xerostomia in head and neck cancer patient(pt)s. The aim of this study was to assess the salivary dysfunction after radiation therapy in pts with head and neck cancer and to evaluate the salivary shielding effect of CT simulation technique by salivary scintigraphy. Fifteen pts (mean age: 48±15) who had been irradiated to head and neck for various malignancies (papillary thyroid cancer: 5, nasopharyngeal cancer: 4, lymphoma: 3, other: 4) underwent salivary scintigraphy with Tc-99m pertechnetate before and 4-6 months after radiation theraphy (mean interval: 158±33 days). The mean neck radiation dose was 58±11 cGy. Ten salivary glands (9 parotid glands, 1 submandibular gland) were shielded from radiation (less than 30 cGy of mean dose in 80% volume of gland). Using salivary scintigraphy, secretory function (uptake20; glandular uptake at 20 minute/ background uptake) and excretory function (EF: %washout after stimulation of orange juice) of each glands were obtained. Fifty seven salivary glands were analyzed. In irradiated glands (n=47), the EF values of both parotid and submanidibular glands were significantly, decreased compared with before radiation (59.3±26.4 vs 15.9±28.4, 56.6±22.9 vs 12.6±21.9 respectively, p20 values of both parotid and submandibular glands were also significantly decreased after radiation (4.0±1.8 vs2.4±0.9, p20 and EF values of shielded glands before and after radiation therapy showed no significant difference (3.9±1.9 vs 3.9±2.4, 56.97±27.8 vs 55.9±28.5, respectively). In radiation therapy of head and neck cancer, salivary dysfunction can be prevented using radiation shield by CT simulation technique. Salivary scintigraphy is a useful non-invasive tool for quantitative assessment of radiation-induced salivary dysfunction and shielding effect