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Sample records for assessment platform cap

  1. A mobile phone-based care model for outpatient cardiac rehabilitation: the care assessment platform (CAP

    Directory of Open Access Journals (Sweden)

    Francis Rebecca

    2010-01-01

    Full Text Available Abstract Background Cardiac rehabilitation programs offer effective means to prevent recurrence of a cardiac event, but poor uptake of current programs have been reported globally. Home based models are considered as a feasible alternative to avoid various barriers related to care centre based programs. This paper sets out the study design for a clinical trial seeking to test the hypothesis that these programs can be better and more efficiently supported with novel Information and Communication Technologies (ICT. Methods/Design We have integrated mobile phones and web services into a comprehensive home- based care model for outpatient cardiac rehabilitation. Mobile phones with a built-in accelerometer sensor are used to measure physical exercise and WellnessDiary software is used to collect information on patients' physiological risk factors and other health information. Video and teleconferencing are used for mentoring sessions aiming at behavioural modifications through goal setting. The mentors use web-portal to facilitate personal goal setting and to assess the progress of each patient in the program. Educational multimedia content are stored or transferred via messaging systems to the patients phone to be viewed on demand. We have designed a randomised controlled trial to compare the health outcomes and cost efficiency of the proposed model with a traditional community based rehabilitation program. The main outcome measure is adherence to physical exercise guidelines. Discussion The study will provide evidence on using mobile phones and web services for mentoring and self management in a home-based care model targeting sustainable behavioural modifications in cardiac rehabilitation patients. Trial registration The trial has been registered in the Australian New Zealand Clinical Trials Registry (ANZCTR with number ACTRN12609000251224.

  2. 高度重视临床研究伦理平台建设,大力推进我国CAP评估%Attach Great Importance to Clinical Research Ethics Platform Construction, and Vigorously Promote China CAP Assessment

    Institute of Scientific and Technical Information of China (English)

    白桦; 王思成; 熊宁宁; 张金钟; 张忠元; 徐春波

    2013-01-01

    2012年9月国家中医药管理局正式委托世界中医药学会联合会组织开展“中医药临床研究伦理审查平台评估”(CAP)。通过对已完成评估的20家医疗卫生机构的伦理审查平台情况进行综合分析,结合当前美国的伦理监管体系,论述我国自主评估品牌CAP的重要特点,“以评促建”和“持续改进”的实践与受益,以及大力推进CAP评估的重要意义。%In September 2012, the "Assessment for Ethics Review of Traditional Chinese Medicine (TCM) Re-search with Human Participants" (named CAP, Chinese medicine assessment human research protection system) was officially commissioned to the World Federation of Chinese Medicine Societies to organize by the State Ad-ministration of TCM. Through the assessment of 20 medical institutions, a comprehensive analysis on ethical re-view platform was conducted. Combined with current regulatory system of ethics in the U.S., this article discussed independent assessment on important CAP features of local brands, the practice and benefit of "construction pro-motion based on assessment" and "continuous improvement," as well as the importance of vigorously promote CAP assessment .

  3. Assessing the value of price caps and floors

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This publication assesses the long-term economic and climatic effects of introducing price caps and price floors in hypothetical global climate change mitigation policy. Based on emission trends, abatement costs and equilibrium climate sensitivity from IPCC and IEA reports, this quantitative analysis confirms that price caps could significantly reduce economic uncertainty. This uncertainty stems primarily from unpredictable economic growth and energy prices, and ultimately unabated emission trends. In addition, the development of abatement technologies is uncertain. Furthermore,this analysis shows that rigid targets may entail greater economic risks with little or no comparative advantage for the climate. More ambitious emission objectives, combined with price caps and price floors, could still entail significantly lower expected costs while driving similar, or even slightly better, climatic outcomes in probabilistic terms.

  4. Whole-Exome Enrichment with the Roche NimbleGen SeqCap EZ Exome Library SR Platform

    OpenAIRE

    Chen, Rui; Im, Hogune; Snyder, Michael

    2015-01-01

    Multiple platforms are available for whole-exome enrichment and sequencing (WES). This protocol is based on the Roche NimbleGen SeqCap EZ Exome Library SR platform, which enriches for ~44 Mb of the human exonic regions. The SeqCap system uses 55- to 105-base DNA probes to capture known coding DNA sequences (CDS) from the NCBI Consensus CDS Database, RefSeq, and Sanger miRBase. The protocol can be performed at the benchside without the need for automation, and the resulting library can be used...

  5. A tailless timing belt climbing platform utilizing dry adhesives with mushroom caps

    Science.gov (United States)

    Krahn, J.; Liu, Y.; Sadeghi, A.; Menon, C.

    2011-11-01

    In many instances, a climbing robot that utilizes dry adhesives as an attachment method may be found to be very useful due to the inherent nature of biomimetic fibrillar dry adhesives in the applications of space, security, surveillance and nuclear reactor cleaning and maintenance. In this paper, a novel tank-like modular robot is developed that does not require a tail to provide a preload to the front of the robot while climbing. Biomimetic fibrillar dry adhesives with mushroom caps manufactured into belts are used as an attachment method. The manufacturing of the dry adhesive belts is discussed and the adhesion properties are examined. The timing belt based climbing platform (TBCP-II) utilizes two tank-like modules connected with an active joint with continual surface-robot distance measuring providing feedback for active adhesive preloading. The mechanical, electronic and software design is discussed. Reliable vertical surface climbing is achieved and the preloading strategy and response is examined. TBCP-II is shown to be capable of both horizontal to vertical and vertical to horizontal surface transfers over both inside and outside corners.

  6. Magnetic susceptibility variations of the Ediacaran cap carbonates in the Yangtze platform and their implications for paleoclimate

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Magnetic susceptibility (MS) data were obtained from 11 sections of the Doushantuo (Ediacaran) cap carbonate that directly overlies the Nantuo glacial diamictite in the southeastern margin of the Yangtze platform. The MS data revealed two regionally correlatable peaks at the bottom and top of the cap carbonate, separated by an interval of low values. The lower MS peak coincides with high percentage of insoluble siliciclastic residues that are compositionally identical to the matrix of the underlying diamictite, suggesting its origin controlled mainly by detrital components during the first phase of cap carbonate deposition at the end of the glaciation. The upper MS peak is associated with high clay content and iron sulfides, and can be interpreted as either derived from enhanced greenhouse weathering that could have brought more terrigenous components into the ocean, or the result of ocean anoxia at the late stage of cap carbonate deposition that could led to formation of abundant iron sulfides. The regionally consistent MS curves from the cap carbonates provided the first geophysical record for the rapid climate change from icehouse to greenhouse conditions in the aftermath of the Neoproterozoic "snowball Earth" event.

  7. Cross-platform digital assessment forms for evaluating surgical skills

    DEFF Research Database (Denmark)

    Andersen, Steven Arild Wuyts

    2015-01-01

    containing the digital assessment forms, because this software has cross-platform functionality on both desktop computers and handheld devices. The database is hosted online, and the rating forms can therefore also be accessed through most modern web browsers. Cross-platform digital assessment forms were...

  8. CAPS Capsule: The National Assessment of Educational Progress, Concept and Organization, Vol. 3, No. 2.

    Science.gov (United States)

    Mattson, Judith, Ed.

    The Winter, 1970 issue of CAPS Capsule concerns the concept and structure of the National Assessment of Educational Progress (NAEP), which responds to the need to look at the outputs of education. Frank B. Womer, Staff Director of NAEP, discusses the following: (1) NAEP's origin; (2) the subject areas selected for assessment; (3) the development…

  9. Cross-platform digital assessment forms for evaluating surgical skills

    Directory of Open Access Journals (Sweden)

    Steven Arild Wuyts Andersen

    2015-04-01

    Full Text Available A variety of structured assessment tools for use in surgical training have been reported, but extant assessment tools often employ paper-based rating forms. Digital assessment forms for evaluating surgical skills could potentially offer advantages over paper-based forms, especially in complex assessment situations. In this paper, we report on the development of cross-platform digital assessment forms for use with multiple raters in order to facilitate the automatic processing of surgical skills assessments that include structured ratings. The FileMaker 13 platform was used to create a database containing the digital assessment forms, because this software has cross-platform functionality on both desktop computers and handheld devices. The database is hosted online, and the rating forms can therefore also be accessed through most modern web browsers. Cross-platform digital assessment forms were developed for the rating of surgical skills. The database platform used in this study was reasonably priced, intuitive for the user, and flexible. The forms have been provided online as free downloads that may serve as the basis for further development or as inspiration for future efforts. In conclusion, digital assessment forms can be used for the structured rating of surgical skills and have the potential to be especially useful in complex assessment situations with multiple raters, repeated assessments in various times and locations, and situations requiring substantial subsequent data processing or complex score calculations.

  10. Atherosclerotic plaque fibrous cap assessment under an oblique scan plane orientation in carotid MRI

    NARCIS (Netherlands)

    Nieuwstadt, H.A.; Van der Lugt, A.; Kassar, Z.A.M.; Breeuwer, M.; Van der Steen, A.F.W.; Gijsen, F.J.H.

    2014-01-01

    Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e.

  11. After the Cap: Risk Assessment, Citizen Science and Disaster Recovery

    Directory of Open Access Journals (Sweden)

    Sabrina McCormick

    2012-12-01

    Full Text Available I used the 2010 Deepwater Horizon oil spill to examine how crowdsourcing is used as a new form of citizen science that provides real time assessments of health-related exposures. Assessing risks of an oil spill, or disasters more generally, is a challenge complicated by the situated nature of knowledge-generation that results in differential perceptions and responses. These processes are critical in the case of the British Petroleum spill in the Gulf Coast since the identification of risks promises to have ramifications for multiple social actors, as well as the health status and long-term resilience of communities in the area. Qualitative interviews, ethnographic observations, and video data were collected with local social movement organizations, grassroots groups, spill workers, fisherman, local residents, scientists, and government representatives within five months of the spill. Findings suggest that crowdsourcing is a new form of citizen science reflecting a transition from lay mapping to an online data gathering system that allows a broader range of participation and the detection of a broader range of impacts. Outcomes of this research promise to help demonstrate and theorize how citizen science relates to risk assessment processes and affects disaster recovery and long-term response.

  12. Wikis as Platforms for Authentic Assessment

    Science.gov (United States)

    Eddy, Pamela L.; Lawrence, April

    2013-01-01

    Calls for accountability focus attention on assessment of student learning. Authentic assessment involves evaluating student learning as students perform real world tasks. We present a four-stage conceptual framework for authentic assessment. We argue first that evaluation is a process rather than a static one-time event. Second, authentic…

  13. Price caps and price floors in climate policy: a quantitative assessment

    Energy Technology Data Exchange (ETDEWEB)

    Philibert, Cedric

    2008-12-15

    This study assesses the long-term economic and environmental effects of introducing price caps and price floors in hypothetical climate change mitigation architecture, which aims to reduce global energy-related CO2 emissions by 50% by 2050. Based on abatement costs in IPCC and IEA reports, this quantitative analysis confirms what qualitative analyses have already suggested: introducing price caps could significantly reduce economic uncertainty. This uncertainty stems primarily from unpredictable economic growth and energy prices, and ultimately unabated emission trends. In addition, the development of abatement technologies is uncertain. With price caps, the expected costs could be reduced by about 50% and the uncertainty on economic costs could be one order of magnitude lower. Reducing economic uncertainties may spur the adoption of more ambitious policies by helping to alleviate policy makers' concerns of economic risks. Meanwhile, price floors would reduce the level of emissions beyond the objective if the abatement costs ended up lower than forecasted. If caps and floors are commensurate with the ambition of the policy pursued and combined with slightly tightened emission objectives, climatic results could be on average similar to those achieved with 'straight' objectives (i.e. with no cost-containment mechanism). (auth)

  14. Design and Assessment of an Intelligent Activity Monitoring Platform

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    Monique Thonnat

    2005-08-01

    Full Text Available We are interested in designing a reusable and robust activity monitoring platform. We propose three good properties that an activity monitoring platform should have to enable its reusability for different applications and to insure performance quality: (1 modularity and flexibility of the architecture, (2 separation between the algorithms and the a priori knowledge they use, and (3 automatic evaluation of algorithm results. We then propose a development methodology to fulfill the last two properties. The methodology consists in the interaction between end-users and developers during the whole development of a specific monitoring system. To validate our approach, we present a platform used to generate activity monitoring systems dedicated to specific applications, we also describe in details the technical validation and the end-user assessment of an automatic metro monitoring system built with the platform and briefly the validation results for bank agency monitoring and building access control.

  15. PROPOSED PROCEDURE FOR ASSESSMENT OF EXISTING PLATFORMS IN INDONESIA

    OpenAIRE

    Ricky L. Tawekal

    2005-01-01

    Off-shore platforms were built since the 1970âs in Indonesia, but there is no local code or recommended practice for their design or assessment procedure. The common practice is to use the recommended practice issued by the American Petroleum Institute, API RP2A. The off-shore platforms built in the 1970âs must be re-qualified due to exceedance of the design life. This paper discuss the assessment procedure given in the API RP2A WSD 21th edition, API RP2A LRFD, dan ISO 19902 (draft E â 2001)....

  16. Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery

    KAUST Repository

    Patil, Sachin

    2016-06-29

    Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light responsive nanostructures.Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible light irradiation leading up to 90% of gene silencing in live cells.

  17. Safety assessment of platform loadout procedures based on unascertained measures

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Safety assessment of offshore platforms is an urgent task. Such assessments are now focusing on the structure,maintenance, and retirement of a platform. Some methods employed have many shortcomings. For example, they cannot make the reliability adequately explicable. Therefore, a mathematical tool, the unascertained measure, was introduced. First, the basic knowledge of the unascertained sets was introduced briefly. Second, the unascertained measure was defined and credible identification was set up. The method has been introduced into the fields for safety assessment of a jacket loadout procedure.Engineering practices showed that it can complete the safety assessment systematically and scientifically without any assumption. The work should have significance in theory and practice for offshore engineering.

  18. Platform for Assessing Strategic Alignment Using Enterprise Architecture: Application to E-Government Process Assessment

    CERN Document Server

    Elhari, Kaoutar

    2011-01-01

    This paper presents an overview of S2AEA (v2) (Strategic Alignment Assessment based on Enterprise Architecture (version2)), a platform for modelling enterprise architecture and for assessing strategic alignment based on internal enterprise architecture metrics. The idea of the platform is based on the fact that enterprise architecture provides a structure for business processes and information systems that supports them. This structure can be used to measure the degree of consistency between business strategies and information systems. In that sense, this paper presents a platform illustrating the role of enterprise architecture in the strategic alignment assessment. This assessment can be used in auditing information systems. The platform is applied to assess an e-government process.

  19. Platform for Assessing Strategic Alignment Using Enterprise Architecture: Application to E-Government Process Assessment

    Directory of Open Access Journals (Sweden)

    Kaoutar Elhari

    2011-01-01

    Full Text Available This paper presents an overview of S2AEA (v2 (Strategic Alignment Assessment based on Enterprise Architecture (version2, a platform for modelling enterprise architecture and for assessing strategic alignment based on internal enterprise architecture metrics. The idea of the platform is based on the fact that enterprise architecture provides a structure for business processes and information systems that supports them. This structure can be used to measure the degree of consistency between business strategies and information systems. In that sense, this paper presents a platform illustrating the role of enterprise architecture in the strategic alignment assessment. This assessment can be used in auditing information systems. The platform is applied to assess an e-government process.

  20. System Reliability Assessment of Existing Jacket Platforms in Malaysian Waters

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    V.J. Kurian

    2014-12-01

    Full Text Available Reliability of offshore platforms has become a very important issue in the Malaysian Oil and Gas Industry as, majority of the jacket platforms in Malaysian waters to date, have exceeded their design life. Reliability of a jacket platform can be assessed through reliability index and probability of failure. Conventional metocean consideration uses 100 year return period wave height associated with 100 year return period current velocity and wind speed. However, recent study shows that for Malaysian waters, the proposed metocean consideration should be 100 year return period wave height associated with 10 year return period current velocity and wind speed. Hence, this research investigated the effect of different metocean consideration, to system-based reliability of jacket platforms in Malaysian waters. Prior to that, the effect of different metocean consideration to the pushover analysis has also been studied. Besides, the significance of Pile Soil Interaction (PSI, wave direction and platform geometry were analyzed in a sensitivity study. Pushover analysis was performed on three jacket platforms representing three water regions in Malaysia to obtain Reserve Strength Ratio (RSR as an indicator of the reliability of the jackets. Utilizing sensitivity study parameters mentioned above, seven different case studies were undertaken to study their significance on RSR. The RSR values of each case study were compared and incorporated as resistance model of reliability analysis. Besides, platform specific response model of each jacket has been generated using response surface technique which was later incorporated into the limit state function for reliability analysis. Reliability analysis using First Order Reliability Method (FORM has been conducted in MATLAB to obtain the reliability index and probability of failure. Results from the reliability analysis were compared to analyze the effect of different metocean consideration. In this study, an updated

  1. PROPOSED PROCEDURE FOR ASSESSMENT OF EXISTING PLATFORMS IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Ricky L. Tawekal

    2005-01-01

    Full Text Available Off-shore platforms were built since the 1970’s in Indonesia, but there is no local code or recommended practice for their design or assessment procedure. The common practice is to use the recommended practice issued by the American Petroleum Institute, API RP2A. The off-shore platforms built in the 1970’s must be re-qualified due to exceedance of the design life. This paper discuss the assessment procedure given in the API RP2A WSD 21th edition, API RP2A LRFD, dan ISO 19902 (draft E – 2001. Problems usually arise due to the fact that the original design was based on API RP2A 10th edition and assessment is done using the new edition which is the 21th edition. Abstract in Bahasa Indonesia : Sejak tahun 1970-an di Indonesia terdapat banyak anjungan lepas pantai, tetapi sampai saat ini belum ada peraturan atau tata cara untuk perencanaan dan penelaahannya. Anjungan lepas pantai biasanya direncanakan berdasarkan Recommended Practice yang diterbitkan oleh American Petroleum Institute, API RP2A. Pada saat ini dirasakan adanya kebutuhan untuk melakukan penelaahan kelayakan struktur anjungan lepas pantai yang telah dibangun sejak tahun 1970-an tersebut. Makalah ini membahas prosedur cara penelaahan anjungan lepas pantai yang diatur dalam API RP2A WSD edisi 21, API RP2A LRFD, dan ISO 19902 (draft E – 2001. Masalah biasanya akan timbul karena perencanaan didasarkan kepada API RP2A edisi 10 sedangkan penelaahan kelayakan didasarkan kepada edisi yang terbaru (edisi 21

  2. Clinical and Radiographic Assessment of the Efficacy of Calcium Silicate Indirect Pulp Capping

    Science.gov (United States)

    Hashem, D.; Mannocci, F.; Patel, S.; Manoharan, A.; Brown, J.E.; Watson, T.F.

    2015-01-01

    The aims of this study were to assess the effectiveness of calcium silicate cement (Biodentine) versus glass ionomer cement (GIC; control group) as indirect pulp capping materials in patients with reversible pulpitis and to compare the effectiveness of cone beam computed tomography (CBCT) versus periapical (PA) radiographs in detecting PA changes at baseline (T0) and at 12 mo (T12) postoperatively. Seventy-two restorations (36 Biodentine, 36 Fuji IX) were placed randomly in 53 patients. CBCT/PA radiographs were taken at T0 and T12. Two calibrated examiners assessed the presence/absence and increase/decrease in the size of existing PA radiolucencies under standardized conditions. The Kappa coefficient evaluated statistically the effectiveness of CBCT versus PA radiographs in detecting PA changes. Chi-square/Mann-Whitney tests were used to evaluate the association between PA changes in CBCT with various clinical measures. Significance was predetermined at α = 0.05. Clinical success rates for Biodentine and Fuji IX GIC were 83.3%. CBCT was significantly more effective in detecting PA radiolucencies compared with radiographs (P = 0.0069). Of the teeth, 65.4% and 90.4% were deemed healthy using CBCT and PA radiographs, respectively, at T12. Healing/healed rates were 17.3%/0%, while new/progressed radiolucency were 30.8%/9.6% with CBCT/PA radiographs, respectively. Seventy-one percent of healed lesions had received Biodentine; 88% of new/progressed lesions received Fuji IX GIC. Teeth presenting with an initial CBCT PA lesion had a failure rate of 63%, whereas teeth with no initial lesion had a failure rate of 16%. Although no statistically significant difference was detected in the clinical efficacy of Biodentine/Fuji IX when used as indirect pulp capping materials in patients with reversible pulpitis, CBCT showed a significant difference in that most healed CBCT lesions had received Biodentine while most that did not heal received Fuji IX. Longer-term follow-up is

  3. Status of Net Metering: Assessing the Potential to Reach Program Caps

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.; Gelman, R.; Bird, L.

    2014-09-01

    Several states are addressing the issue of net metering program caps, which limit the total amount of net metered generating capacity that can be installed in a state or utility service territory. In this analysis, we examine net metering caps to gain perspective on how long net metering will be available in various jurisdictions under current policies. We also surveyed state practices and experience to understand important policy design considerations.

  4. Assessment of potential anaerobic biotransformation of organic pollutants in sediment caps.

    Science.gov (United States)

    Smith, Anthony M; Kirisits, Mary Jo; Reible, Danny D

    2012-11-15

    In situ capping is a remedial approach for reducing the risk of biota exposure to sediment contaminants. Biotransformation of contaminants in sand-based sediment caps, rarely considered in sediment cap design, could further reduce the exposure risk. The anaerobic biotransformation of benzene, toluene, ethylbenzene, xylenes (BTEX), monochlorobenzene, dichlorobenzenes and naphthalene was evaluated with sediments from Onondaga Lake in dilute sediment slurries and in sand-capped sediment laboratory-scale columns. The percentage of sediment samples demonstrating biotransformation under anaerobic conditions in slurries incubated at 12°C was greatest for BTEX, followed by monochlorobenzene, 1,4-dichlorobenzene, 1,2-dichlorobenzene and 1,3-dichlorobenzene. Only toluene biotransformation was observed in sand cap columns. The rate of toluene biotransformation diminished over time, which might be due to inhibition caused by hydrogen from the experimental setup. Results suggest potential for the biotransformation of toluene, and possibly other pollutants, in sand-based sediment caps under anaerobic conditions at low temperatures.

  5. ASSESSMENT OF RADIONUCLIDES DATABASES IN CAP88 MAINFRAME VERSION 1.0 AND WINDOWS-BASED VERSION 3.0

    Energy Technology Data Exchange (ETDEWEB)

    Farfan, E.; Lee, P.; Jannik, T.; Donnelly, E.

    2008-09-16

    In this study the radionuclide databases for two versions of the Clean Air Act Assessment Package-1988 (CAP88) computer model were assessed in detail. CAP88 estimates radiation dose and the risk of health effects to human populations from radionuclide emissions to air. This program is used by several Department of Energy (DOE) facilities to comply with National Emission Standards for Hazardous Air Pollutants (NESHAP) regulations. CAP88 Mainframe, referred to as Version 1.0 on the Environmental Protection Agency (EPA) website (http://www.epa.gov/radiation/assessment/CAP88/), was the very first CAP88 version released in 1988. Some DOE facilities including the Savannah River Site still employ this version (1.0) while others use the more user-friendly personal computer Windows-based Version 3.0 released in December 2007. Version 1.0 uses the program RADRISK based on International Commission on Radiological Protection (ICRP) Publication 30 as its radionuclide database. Version 3.0 uses half-life, dose and risk factor values based on Federal Guidance Report 13. Differences in these values could cause different results for the same input exposure data (same scenario), depending on which version of CAP88 is used. Consequently, the differences between the two versions are being assessed in detail at Savannah River National Laboratory. The version 1.0 and 3.0 database files contain 496 and 838 radionuclides, respectively, and though one would expect the newer version to include all the 496 radionuclides, thirty-five radionuclides are listed in version 1.0 that are not included in version 3.0. The majority of these has either extremely short or long half-lives or is no longer in production; however, some of the short-lived radionuclides might produce progeny of great interest at DOE sites. In addition, one hundred and twenty-two radionuclides were found to have different half-lives in the two versions, with 21 over 3 percent different and 12 over 10 percent different.

  6. Assessing the measurement of aerosol single scattering albedo by Cavity Attenuated Phase-Shift Single Scattering Monitor (CAPS PMssa)

    Science.gov (United States)

    Perim de Faria, Julia; Bundke, Ulrich; Onasch, Timothy B.; Freedman, Andrew; Petzold, Andreas

    2016-04-01

    The necessity to quantify the direct impact of aerosol particles on climate forcing is already well known; assessing this impact requires continuous and systematic measurements of the aerosol optical properties. Two of the main parameters that need to be accurately measured are the aerosol optical depth and single scattering albedo (SSA, defined as the ratio of particulate scattering to extinction). The measurement of single scattering albedo commonly involves the measurement of two optical parameters, the scattering and the absorption coefficients. Although there are well established technologies to measure both of these parameters, the use of two separate instruments with different principles and uncertainties represents potential sources of significant errors and biases. Based on the recently developed cavity attenuated phase shift particle extinction monitor (CAPS PM_{ex) instrument, the CAPS PM_{ssa instrument combines the CAPS technology to measure particle extinction with an integrating sphere capable of simultaneously measuring the scattering coefficient of the same sample. The scattering channel is calibrated to the extinction channel, such that the accuracy of the single scattering albedo measurement is only a function of the accuracy of the extinction measurement and the nephelometer truncation losses. This gives the instrument an accurate and direct measurement of the single scattering albedo. In this study, we assess the measurements of both the extinction and scattering channels of the CAPS PM_{ssa through intercomparisons with Mie theory, as a fundamental comparison, and with proven technologies, such as integrating nephelometers and filter-based absorption monitors. For comparison, we use two nephelometers, a TSI 3563 and an Aurora 4000, and two measurements of the absorption coefficient, using a Particulate Soot Absorption Photometer (PSAP) and a Multi Angle Absorption Photometer (MAAP). We also assess the indirect absorption coefficient

  7. Preliminary Assessment of Nitrous Oxide Offsets in a Cap and Trade Program

    OpenAIRE

    Ribaudo, Marc; Delgado, Jorge; Livingston, Michael J.

    2011-01-01

    Nitrous oxide is a powerful greenhouse gas that is emitted from cropland treated with nitrogen fertilizer. Reducing such emissions through nutrient management might be able to produce offsets for sale in a cap and trade program aimed at reducing greenhouse gases. We use the Nitrate Leaching and Economic Analysis Program (NLEAP) model and data from the Agricultural and Resource Management Survey to examine what changes in rate, timing, or method of application a farmer would take to produce of...

  8. Liver Steatosis Assessed by Controlled Attenuation Parameter (CAP) Measured with the XL Probe of the FibroScan: A Pilot Study Assessing Diagnostic Accuracy.

    Science.gov (United States)

    Sasso, Magali; Audière, Stéphane; Kemgang, Astrid; Gaouar, Farid; Corpechot, Christophe; Chazouillères, Olivier; Fournier, Céline; Golsztejn, Olivier; Prince, Stéphane; Menu, Yves; Sandrin, Laurent; Miette, Véronique

    2016-01-01

    To assess liver steatosis, the controlled attenuation parameter (CAP; giving an estimate of ultrasound attenuation ∼3.5 MHz) is available with the M probe of the FibroScan. We report on the adaptation of the CAP for the FibroScan XL probe (center frequency 2.5 MHz) without modifying the range of values (100-400 dB/m). CAP validation was successfully performed on Field II simulations and on tissue-mimicking phantoms. In vivo performance was assessed in a cohort of 59 patients spanning the range of steatosis. In vivo reproducibility was good and similar with both probes. The area under receiver operative characteristic curve was equal to 0.83/0.84 and 0.92/0.91 for the M/XL probes to detect >2% and >16% liver fat, respectively, as assessed by magnetic resonance imaging. Patients can now be assessed simultaneously for steatosis and fibrosis using the FibroScan, regardless of their morphology.

  9. Deliverable 3.3.1 - Assessment Methodology on ISISEMD platform

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth

    2009-01-01

    The overall goal of the ISISEMD project is to offer innovative ICT services to improve the quality of life of elderly persons with cognitive problems or mild dementia and their informal and formal caregivers who provide every day care for them. This will be done via the ISISEMD platform...

  10. Colorado Assessment of Problem Solving (CAPS) -- Identifying student's problem solving skills

    Science.gov (United States)

    Adams, Wendy; Wieman, Carl

    2009-05-01

    Problem solving is central to any physics curriculum and physics educators have put extensive effort into understanding successful problem solving; however, there is currently no efficient way to evaluate problem solving skill. Attempts have been made in the past; however, knowledge of the principles required to solve the subject problem are so absolutely critical that they completely overshadow any other skills students may use when solving a problem. The work presented here is unique because CAPS removes the requirement that the student already have a grasp of physics concepts. CAPS has been developed and validated at Colorado and measures a person's competence in 44 separate skills that are used when solving a wide range of in-depth problems including classical mechanics and quantum mechanics problems. Understanding the specific processes that impact how a person solves a problem identifies which components are specific to physics and those that transfer across discipline, and provides insight for improved methods for teaching. 1. Supported in part by funding from National Science Foundation

  11. WCDMA Uplink Interference Assessment from Multiple High Altitude Platform Configurations

    Directory of Open Access Journals (Sweden)

    A. Mohammed

    2008-06-01

    Full Text Available We investigate the possibility of multiple high altitude platform (HAP coverage of a common cell area using a wideband code division multiple access (WCDMA system. In particular, we study the uplink system performance of the system. The results show that depending on the traffic demand and the type of service used, there is a possibility of deploying 3–6 HAPs covering the same cell area. The results also show the effect of cell radius on performance and the position of the multiple HAP base stations which give the worst performance.

  12. Probabilistic Reliability Assessment of Truss Construction in Matlab Software Platform

    OpenAIRE

    Vašek Jakub; Krejsa Martin

    2014-01-01

    This paper deals with the use of probabilistic methods in assessing the reliability of the planar truss support structure. Classical Monte Carlo simulation technique was chosen for calculation of failure probability in structural elements and the entire support system under assessment. Numerical calculation was applied in MATLAB software system using the random number generator and parallelization using multi-core processors. The aim of the study was to analyze the usability of MATLAB for pro...

  13. An integrated platform for assessing biologics (Conference Presentation)

    Science.gov (United States)

    Schein, Perry; O'Dell, Dakota; Erickson, David

    2016-04-01

    Protein therapeutics are a rapidly growing portion of the pharmaceuticals market and have many significant advantages over traditional small molecule drugs. As this market expands, however, critical regulatory and quality control issues remain, most notably the problem of protein aggregation. Individual target proteins often aggregate into larger masses which trigger an immune response in the body, which can reduce the efficacy of the drug for its intended purpose, or cause serious anaphylactic side-effects. Although detecting and minimizing aggregate formation is critical to ensure an effective product, aggregation dynamics are often highly complicated and there is little hope of reliable prediction and prevention from first principles. This problem is compounded for aggregates in the subvisible range of 100 nm to 10 micrometers where traditional techniques for detecting aggregates have significant limitations. Here, we present an integrated optofluidic platform for detecting nanoscale protein aggregates and characterizing interactions between these aggregates and a reference surface. By delivering light to a solution of proteins with an optical waveguide, scattered light from individual protein aggregates can be detected and analyzed to determine the force profile between each particle and the waveguide surface. Unlike existing methods which only determine size or charge, our label-free screening technique can directly measure the surface interaction forces between single aggregates and the glass substrate. This direct measurement capability may allow for better empirical predictions of the stability of protein aggregates during drug manufacturing and storage.

  14. Offshore Platform Hydrocarbon Risk Assessment – OPHRA: Feasibility

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan; Kozine, Igor; Markert, Frank

    and fire; • Detection, shut down and alarm; • Escape and evacuation; • Exposure and impact on people and equipment This method leads to a transparent framework for modelling, which helps to demonstrate the correctness and appropriateness of models and assumptions. The report lists the (type of) models...... and data needed for the risk assessment framework, and provides specific suggestions for some of those models. Some preliminary calculations with the DES model have been performed to illustrate type of results that can be obtained and to provide some insight in the accuracy and computational efforts....... Finally, further work is identified in order to develop an operational risk assessment tool....

  15. Cell Viability Assessment: Toward Content-Rich Platforms

    Science.gov (United States)

    Ramirez, Christina Nicole; Antczak, Christophe; Djaballah, Hakim

    2013-01-01

    Importance of the field Monitoring cell viability in vitro is critical in many areas of biomedical research, and the ultimate goal in drug discovery is the ability to predict the in vivo toxicology of drug candidates based on their toxicity profile in vitro. Over the last decade, the contribution of high-throughput screening (HTS) toward this goal has been tremendous, providing the ability to screen compounds in parallel against multiple cell types. However, the toxic effects of drug candidates uncovered during clinical trials are by far the main reason for their failure. Over the same period, our understanding of programmed cell death has evolved dramatically with the identification of critical control points in the cell death pathways. As a result, cell viability should no longer be characterized solely on the basis of discrete endpoint measurements such as membrane permeability. Areas covered in this review/What the reader will gain This review summarizes the traditional viability assays currently commercially available, focusing on methods amenable to high density format. Assays categorized into the following classes are discussed: dye exclusion assays, DNA condensation-based assays and assays monitoring a metabolic function. We describe each approach, and using case studies, we emphasize their limitations. Take home message Current low-content methods based on single parameter readouts are prone to error due to the heterogeneity of cell populations and the multi-faceted nature of cell death. High-content approaches based on continuous, multiplexed readouts are becoming increasingly important for monitoring multiple markers of cell death induction simultaneously, on a cell by cell basis. The use of such content-rich platforms is a necessity to predict the toxicology of drug candidates accurately. PMID:22823019

  16. Factors affecting the accuracy of controlled attenuation parameter (CAP in assessing hepatic steatosis in patients with chronic liver disease.

    Directory of Open Access Journals (Sweden)

    Kyu Sik Jung

    Full Text Available BACKGROUND & AIMS: Controlled attenuation parameter (CAP can measure hepatic steatosis. However, factors affecting its accuracy have not been described yet. This study investigated predictors of discordance between liver biopsy (LB and CAP. METHODS: A total of 161 consecutive patients with chronic liver disease who underwent LB and CAP were enrolled prospectively. Histological steatosis was graded as S0 (66% of hepatocytes. Cutoff CAP values were calculated from our cohort (250, 301, and 325 dB/m for ≥ S1, ≥ S2, and S3. Discordance was defined as a discrepancy of at least two steatosis stages between LB and CAP. RESULTS: The median age (102 males and 59 females was 49 years. Repartition of histological steatosis was as follows; S0 26.1% (n = 42, S1 49.7% (n = 80, S2 20.5% (n = 33, and S3 3.7% (n = 6. In multivariate linear regression analysis, CAP value was independently associated with steatosis grade along with body mass index (BMI and interquartile range/median of CAP value (IQR/MCAP (all P<0.05. Discordance was identified in 13 (8.1% patients. In multivariate analysis, histological S3 (odd ratio [OR], 9.573; 95% confidence interval [CI], 1.207-75.931; P = 0.033 and CAP value (OR, 1.020; 95% CI, 1.006-1.034; P = 0.006 were significantly associated with discordance, when adjusting for BMI, IQR/MCAP, and necroinflammation, reflected by histological activity or ALT level. CONCLUSIONS: Patients with high grade steatosis or high CAP values have a higher risk of discordance between LB and CAP. Further studies are needed to improve the accuracy of CAP interpretation, especially in patients with higher CAP values.

  17. Accuracy assessment of the integration of GNSS and a MEMS IMU in a terrestrial platform.

    Science.gov (United States)

    Madeira, Sergio; Yan, Wenlin; Bastos, Luísa; Gonçalves, José A

    2014-11-04

    MEMS Inertial Measurement Units are available at low cost and can replace expensive units in mobile mapping platforms which need direct georeferencing. This is done through the integration with GNSS measurements in order to achieve a continuous positioning solution and to obtain orientation angles. This paper presents the results of the assessment of the accuracy of a system that integrates GNSS and a MEMS IMU in a terrestrial platform. We describe the methodology used and the tests realized where the accuracy of the positions and orientation parameters were assessed using an independent photogrammetric technique employing cameras that integrate the mobile mapping system developed by the authors. Results for the accuracy of attitude angles and coordinates show that accuracies better than a decimeter in positions, and under a degree in angles, can be achieved even considering that the terrestrial platform is operating in less than favorable environments.

  18. Construction of life cycle assessment software system platform

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ya-ping; ZUO Yu-hui

    2007-01-01

    There has not been life cycle assessment (LCA) software applicable to China's products. To faciliate the develop-ment of LCA software system in China, we built an object-oriented LCA software system plantform based on LCA international standards ISO 14040 to ISO 14043 and the commonness of diverse products. The system includes six modules: disassembly module, data collection module, arithmetic module, drawing module, database module and control module. It evaluates all economic and environmental impacts during the whole life cycle of a product. The integrated life cycle inventory database system allows dynamic expansion, which makes the effort required for data collection reduce with the increase of the system's application. With the improvement of human environmental-awareness, the demand of environment-friendly products is increasing, and ecological design of products has become a critical part in products development. Consummation of the LCA software system will provide a powerful tool for designing and developing Chinese ecological products.

  19. The ORNL Indoor Air Quality Study: Re-cap, Context, and Assessment on Radon

    Energy Technology Data Exchange (ETDEWEB)

    Tonn, Bruce Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rose, Erin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ternes, Mark P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    As part of the retrospective evaluation of the U.S. Department of Energy s low-income Weatherization Assistance Program that was led by Oak Ridge National Laboratory (ORNL), an assessment of the impacts of weatherization on indoor air quality (IAQ) was conducted. This assessment included nearly 500 treatment and control homes across the country. Homes were monitored for carbon monoxide, radon, formaldehyde, temperature and humidity pre- and post-weatherization. This report focuses on the topic of radon and addresses issues not thoroughly discussed in the original IAQ report. The size, scope and rigor of the radon component of the IAQ study are compared to previous studies that assessed the impacts of weatherization on indoor radon levels. It is found that the ORNL study is by far the most extensive study conducted to date, though the ORNL results are consistent with the findings of the other studies. However, the study does have limitations related to its reliance on short-term measurements of radon and inability to attribute changes in radon levels in homes post-weatherization to specific weatherization measures individually or in combination.

  20. Exergetic assessment of energy systems on North Sea oil and gas platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Pierobon, Leonardo; Elmegaard, Brian;

    2013-01-01

    offshore system is described: its thermodynamic performance is assessed by performing an exergy accounting and rules of thumb for oil and gas platforms are derived. Simulations are built and conducted with the tools Aspen Plus_, Dynamic Network Analysis and Aspen HYSYS_. 62e65% of the total exergy...

  1. A Global Refiability Assessment Method on Aging Offshore Platforms with Corrosion and Cracks

    Institute of Scientific and Technical Information of China (English)

    JI Chun-yan; LI Shan-shan; CHEN Ming-lu

    2009-01-01

    Corrosion and fatigue cracks are major threats to the structural integrity of aging offshore platforms.For the rational estimation of the safety levels of aging platforms,a global reliability assessment approach for aging offshore platforms with corrosion and fatigue cracks is presented in this paper.The base shear capacity is taken as the global ultimate strength of the offshore plaffoms,it is modeled as a random process that decreases with time in the presence of corrosion and fatigue crack propagation.And the corrosion and fatigue crack growth rates in the main members and key joints are modeled as random variables.A simulation method of the extreme wave loads which are applied to the structures of offshore platforms is proposed too.Furthermore,the statistics of global base shear capacity and extreme wave loads are obtained by Monte Carlo simulation method.On the basis of the limit state equation of global failure mode,the instantaneous reliability and time dependent reliability assessment methods are both presented in this paper.Finally the instantaueous reliability index and time dependent failure probability of a jacket platform are estimated with different ages in the demonstration example.

  2. Thermo-economic assessment of the integration of steam cycles on offshore platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter;

    2014-01-01

    The integration of steam bottoming cycles on oil platforms is often seen as a possible route to mitigate the CO2-emissions offshore. In this paper, a North Sea platform and its energy requirements are systematically analysed. The site-scale integration of steam networks is assessed by using...... thermodynamic and economic performance indicators. The results illustrate the benefits of converting the gas turbines into a combined cycle. Using seawater results in smaller power generation and greater CO2-emissions than using process water, as the additional power generation in the combined cycle...

  3. Use of the NetBeans Platform for NASA Robotic Conjunction Assessment Risk Analysis

    Science.gov (United States)

    Sabey, Nickolas J.

    2014-01-01

    The latest Java and JavaFX technologies are very attractive software platforms for customers involved in space mission operations such as those of NASA and the US Air Force. For NASA Robotic Conjunction Assessment Risk Analysis (CARA), the NetBeans platform provided an environment in which scalable software solutions could be developed quickly and efficiently. Both Java 8 and the NetBeans platform are in the process of simplifying CARA development in secure environments by providing a significant amount of capability in a single accredited package, where accreditation alone can account for 6-8 months for each library or software application. Capabilities either in use or being investigated by CARA include: 2D and 3D displays with JavaFX, parallelization with the new Streams API, and scalability through the NetBeans plugin architecture.

  4. A Geospatial Web Platform for Natural Hazard Exposure Assessment in the Insurance Sector

    Science.gov (United States)

    Iris, Julien; Chemitte, Jérôme; Napoli, Aldo

    The work of natural hazard exposure assessment involves various geographic data sets (referential, hazard, assets) and various disciplines intended for insurance professionals (catastrophe modeling, prevention engineering). The emergence of Geospatial Web technology induces the emergence of new sets of online services. Mission Risques Naturels (MRN) is a French actor in the mutualization and diffusion of information on natural hazards knowledge and prevention for the general interest of insurance professionals. The MRN Web-GIS platform has been built to address these requirements. This chapter starts by presenting the role of MRN in the network of natural hazard assessment. It then presents Geospatial Web tools for natural hazard exposure assessment as well as the system architecture of the MRN Web-GIS platform, including all its services.

  5. A virtual reality platform for assessment and rehabilitation of neglect using a kinect.

    Science.gov (United States)

    Cipresso, Pietro; Serino, Silvia; Pedroli, Elisa; Gaggioli, Andrea; Riva, Giuseppe

    2014-01-01

    Unilateral Spatial Neglect (USN) is normally assessed with paper-and-pencil tests. Virtual reality can be an effective neuropsychological tool for a more ecological and functional assessment and rehabilitation of neglect. We developed a 3D Virtual Reality platform - NeuroVirtual 3D - for the assessment and rehabilitation of cognitive deficits, in particular for USN. Within the virtual environments it is possible to interact with virtual objects and execute specific exercises using a Microsoft Kinect. Through the analysis of different grasping tasks it is possible to evaluate in an ecological way the patients' ability to find and handle objects in both sides of the virtual space.

  6. USGS National Assessment of Oil and Gas Project - Cherokee Platform Province Assessment Units

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Assessment Unit is the fundamental unit used in the National Assessment Project for the assessment of undiscovered oil and gas resources. The Assessment Unit is...

  7. An integrated telemedicine platform for the assessment of affective physiological states

    OpenAIRE

    Ganiatsas George; Katsis Christos D; Fotiadis Dimitrios I

    2006-01-01

    Abstract AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a) a multisensorial wearable, (b) a data acquisition and wireless communication module, (c) a feature extraction module, (d) a 3D facial animation module which is used for the projectio...

  8. Death cap

    DEFF Research Database (Denmark)

    Rudbæk, Torsten R; Kofoed, Pernille Bouteloup; Bove, Jeppe;

    2014-01-01

    Death cap (Amanita phalloides) is commonly found and is one of the five most toxic fungi in Denmark. Toxicity is due to amatoxin, and poisoning is a serious medical condition, causing organ failure with potential fatal outcome. Acknowledgement and clarification of exposure, symptomatic and focused...... treatment is of primary importance. No data from randomised, controlled trials on management exists, and there is not international consensus on treatment regime. We present amatoxin-case contacts to the Danish Poison Centre from 2006-2012 and summarize current knowledge and Danish recommendations...

  9. SYMBIOSE: A modeling and simulation platform for environmental chemical risk assessment

    International Nuclear Information System (INIS)

    Environmental systems are considered among the most complex ones because they involve a large number of diverse components, interactions, scale issues, spatial heterogeneity and significant sources of uncertainty. An Environmental Chemical Risk Assessment (ECRA) require therefore the integration of a wide range of data and modeling approaches, while accounting for sources and propagation of uncertainties in the system. Further, the level of detail to be achieved in an assessment depends mainly on environmental management objectives and the difficulty of adequately describing exposure, toxicity and other properties of the chemicals with site-specific data. This can range from simplistic conservative analyses to more realistic spatiotemporal modeling approaches. As a consequence, there is a pressing need for integrated, flexible (and user-friendly) tools that could adapt to this shifting and expanding assessment context. The SYMBIOSE project aims at developing such a modeling and simulation platform, for assessing the fate, transport and effects of chemicals - radionuclides and heavy metals, mainly - on humans and biota, in a multi-media environment. The various aspects of an environmental chemical risk assessment process, and existing relationships between them, are first revisited in a comprehensive way with emphasis on valuable modeling techniques. The modeling approach that will be implemented in the platform is then described through keystone aspects such as conceptual, mathematical and spatial modeling aspects. Finally, some key ideas about the object-oriented software architecture that is foreseen are presented. (author)

  10. Radioactive airborne effluents and the environmental impact assessment of CAP1400 nuclear power plant under normal operation

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Qiong; Guo, RuiPing; Zhang, ChunMing; Chen, XiaoQiu; Wang, Bo, E-mail: wangbo@chinansc.cn

    2014-12-15

    Highlights: • Typical radionuclides dispersion from CAP1400 under normal operation was simulated. • Modified Gaussian model considered radioactive decay, dry and wet deposition and so on. • The radioactive impact pathways on the public through atmosphere were compared. • The maximum individual effective dose was lower than the public irradiation limit. - Abstract: China Advanced Passive nuclear power plant with installed capacity reaching to 1400 MW (CAP1400) is independently designed as the China's state-of-the-art third generation nuclear power brand based on AP1000 technology digestion and absorption. The concentration of typical radionuclides dispersed from CAP1400 under normal operation was calculated with modified Gaussian model, considering mixed layer height, dry deposition, wet deposition, radioactive decay and so on. The atmospheric dispersion factors, ground deposition rate, individual dose and public dose were also investigated to estimate the radioactive effects of CAP1400 under normal operation on surrounding environment and human beings. The radioactive impact pathways on the public through atmosphere, such as immersion irradiation in the smoke plume, internal irradiation from ingestion and inhalation and external irradiation from surface deposition were briefly introduced with focus on the comparison of the maximum individual effective dose to different group from atmospheric dispersion. All computation results show that the maximum individual irradiation dose happened to children with total effective irradiation dose of 4.52E−03 mSv/y, which was lower than the public irradiation limit of 0.25 mSv/y.

  11. Assessment of the real-time PCR and different digital PCR platforms for DNA quantification.

    Science.gov (United States)

    Pavšič, Jernej; Žel, Jana; Milavec, Mojca

    2016-01-01

    Digital PCR (dPCR) is beginning to supersede real-time PCR (qPCR) for quantification of nucleic acids in many different applications. Several analytical properties of the two most commonly used dPCR platforms, namely the QX100 system (Bio-Rad) and the 12.765 array of the Biomark system (Fluidigm), have already been evaluated and compared with those of qPCR. However, to the best of our knowledge, direct comparison between the three of these platforms using the same DNA material has not been done, and the 37 K array on the Biomark system has also not been evaluated in terms of linearity, analytical sensitivity and limit of quantification. Here, a first assessment of qPCR, the QX100 system and both arrays of the Biomark system was performed with plasmid and genomic DNA from human cytomegalovirus. With use of PCR components that alter the efficiency of qPCR, each dPCR platform demonstrated consistent copy-number estimations, which indicates the high resilience of dPCR. Two approaches, one considering the total reaction volume and the other considering the effective reaction size, were used to assess linearity, analytical sensitivity and variability. When the total reaction volume was considered, the best performance was observed with qPCR, followed by the QX100 system and the Biomark system. In contrast, when the effective reaction size was considered, all three platforms showed almost equal limits of detection and variability. Although dPCR might not always be more appropriate than qPCR for quantification of low copy numbers, dPCR is a suitable method for robust and reproducible quantification of viral DNA, and a promising technology for the higher-order reference measurement method. PMID:26521179

  12. The TRIPOD e-learning Platform for the Training of Earthquake Safety Assessment

    International Nuclear Information System (INIS)

    The paper summarizes the results of the in progress EU Project titled TRIPOD (Training Civil Engineers on Post-Earthquake Safety Assessment of Damaged Buildings), funded under the Leonardo Da Vinci program. The main theme of the project is the development of a methodology and a learning platform for the training of technicians involved in post-earthquake building safety inspections. In the event of a catastrophic earthquake, emergency building inspections constitute a major undertaking with severe social impact. Given the inevitable chaotic conditions and the urgent need of a great number of specialized individuals to carry out inspections, past experience indicates that inspection teams are often formed in an adhoc manner, under stressful conditions, at a varying levels of technical expertise and experience, sometime impairing the reliability and consistency of the inspection results. Furthermore each Country has its own building damage and safety assessment methodology, developed according to its experience, laws, building technology and seismicity. This holds also for the partners participating to the project (Greece, Italy, Turkey, Cyprus), that all come from seismically sensitive Mediterranean countries. The project aims at alleviating the above shortcomings by designing and developing a training methodology and e-platform, forming a complete training program targeted at inspection engineers, specialized personnel and civil protection agencies. The e-learning platform will provide flexible and friendly authoring mechanisms, self-teaching and assessment capabilities, course and trainee management, etc. Courses will be also made available as stand-alone multimedia applications on CD and in the form of a complete pocket handbook. Moreover the project will offer the possibility of upgrading different experiences and practices: a first step towards the harmonization of methodologies and tools of different Countries sharing similar problems. Finally, through wide

  13. The TRIPOD e-learning Platform for the Training of Earthquake Safety Assessment

    Science.gov (United States)

    Coppari, S.; Di Pasquale, G.; Goretti, A.; Papa, F.; Papa, S.; Paoli, G.; Pizza, A. G.; Severino, M.

    2008-07-01

    The paper summarizes the results of the in progress EU Project titled TRIPOD (Training Civil Engineers on Post-Earthquake Safety Assessment of Damaged Buildings), funded under the Leonardo Da Vinci program. The main theme of the project is the development of a methodology and a learning platform for the training of technicians involved in post-earthquake building safety inspections. In the event of a catastrophic earthquake, emergency building inspections constitute a major undertaking with severe social impact. Given the inevitable chaotic conditions and the urgent need of a great number of specialized individuals to carry out inspections, past experience indicates that inspection teams are often formed in an adhoc manner, under stressful conditions, at a varying levels of technical expertise and experience, sometime impairing the reliability and consistency of the inspection results. Furthermore each Country has its own building damage and safety assessment methodology, developed according to its experience, laws, building technology and seismicity. This holds also for the partners participating to the project (Greece, Italy, Turkey, Cyprus), that all come from seismically sensitive Mediterranean countries. The project aims at alleviating the above shortcomings by designing and developing a training methodology and e-platform, forming a complete training program targeted at inspection engineers, specialized personnel and civil protection agencies. The e-learning platform will provide flexible and friendly authoring mechanisms, self-teaching and assessment capabilities, course and trainee management, etc. Courses will be also made available as stand-alone multimedia applications on CD and in the form of a complete pocket handbook. Moreover the project will offer the possibility of upgrading different experiences and practices: a first step towards the harmonization of methodologies and tools of different Countries sharing similar problems. Finally, through wide

  14. Exergetic assessment of energy systems on North Sea oil and gas platforms

    International Nuclear Information System (INIS)

    Oil and gas platforms in the North Sea region are associated with high power consumption and large CO2-emissions, as the processing and utility plants suffer from significant changes in production rates and performance losses over the field lifespan. In this paper, a generic model of the overall offshore system is described: its thermodynamic performance is assessed by performing an exergy accounting and rules of thumb for oil and gas platforms are derived. Simulations are built and conducted with the tools Aspen Plus®, Dynamic Network Analysis and Aspen HYSYS®. 62–65% of the total exergy destruction of an offshore platform is attributable to the power generation and waste heat recovery system, and 35–38% to the oil and gas processing. The variability of the feed composition has little effect on the split of the thermodynamic irreversibilities between both plants. The rejection of high-temperature gases from the utility and flaring systems is the major contributor to the exergy losses. These findings suggest to focus efforts on a better use of the waste heat contained in the exhaust gases and on the ways in which the gas compression performance can be improved. - Highlights: • North Sea oil and gas platforms are investigated and a generic model is developed. • Exergy analysis of these offshore facilities is performed. • Most of the total exergy destruction is attributable to the utility systems producing the electrical power required onsite. • Rejection of the exhaust gases from the utility systems is the major exergy loss of this system. • The highest thermodynamic performance is reached with low well-fluid content of water and gas

  15. Tile-in-ONE: A web platform which integrates Tile Calorimeter data quality and calibration assessment

    Science.gov (United States)

    Sivolella, A.; Ferreira, F.; Maidantchik, C.; Solans, C.; Solodkov, A.; Burghgrave, B.; Smirnov, Y.

    2015-12-01

    The ATLAS Tile Calorimeter collaboration assesses the quality of calibration data in order to ensure its proper operation. A number of tasks is then performed by executing several tools and accessing web systems, which were independently developed to meet distinct collaboration's requirements and do not necessarily are connected with each other. Thus, to attend the collaboration needs, several programs are usually implemented without a global perspective of the detector, requiring basic software features. In addition, functionalities may overlap in their objectives and frequently replicate resources retrieval mechanisms. Tile-in-ONE is a designed and implemented platform that assembles various web systems used by the calorimeter community through a single framework and a standard technology. It provides an infrastructure to support the code implementation, avoiding duplication of work while integrating with an overall view of the detector status. Database connectors smooth the process of information access since developers do not need to be aware of where records are placed and how to extract them. Within the environment, a dashboard stands for a particular Tile operation aspect and gets together plug-ins, i.e. software components that add specific features to an existing application. A server contains the platform core, which represents the basic environment to deal with the configuration, manage user settings and load plug-ins at runtime. A web middleware assists users to develop their own plug-ins, perform tests and integrate them into the platform as a whole. Backends are employed to allow that any type of application is interpreted and displayed in a uniform way. This paper describes Tile-in-ONE web platform.

  16. Satellite altimeter remote sensing of ice caps

    OpenAIRE

    Rinne, Eero Juhani

    2011-01-01

    This thesis investigates the use of satellite altimetry techniques for measuring surface elevation changes of ice caps. Two satellite altimeters, Radar Altimeter 2 (RA-2) and Geoscience Laser Altimeter System (GLAS) are used to assess the surface elevation changes of three Arctic ice caps. This is the first time the RA-2 has been used to assess the elevation changes of ice caps - targets much smaller than the ice sheets which are the instrument’s primary land ice targets. Algor...

  17. Microchip Screening Platform for Single Cell Assessment of NK Cell Cytotoxicity

    Science.gov (United States)

    Guldevall, Karolin; Brandt, Ludwig; Forslund, Elin; Olofsson, Karl; Frisk, Thomas W.; Olofsson, Per E.; Gustafsson, Karin; Manneberg, Otto; Vanherberghen, Bruno; Brismar, Hjalmar; Kärre, Klas; Uhlin, Michael; Önfelt, Björn

    2016-01-01

    Here, we report a screening platform for assessment of the cytotoxic potential of individual natural killer (NK) cells within larger populations. Human primary NK cells were distributed across a silicon–glass microchip containing 32,400 individual microwells loaded with target cells. Through fluorescence screening and automated image analysis, the numbers of NK and live or dead target cells in each well could be assessed at different time points after initial mixing. Cytotoxicity was also studied by time-lapse live-cell imaging in microwells quantifying the killing potential of individual NK cells. Although most resting NK cells (≈75%) were non-cytotoxic against the leukemia cell line K562, some NK cells were able to kill several (≥3) target cells within the 12-h long experiment. In addition, the screening approach was adapted to increase the chance to find and evaluate serial killing NK cells. Even if the cytotoxic potential varied between donors, it was evident that a small fraction of highly cytotoxic NK cells were responsible for a substantial portion of the killing. We demonstrate multiple assays where our platform can be used to enumerate and characterize cytotoxic cells, such as NK or T cells. This approach could find use in clinical applications, e.g., in the selection of donors for stem cell transplantation or generation of highly specific and cytotoxic cells for adoptive immunotherapy. PMID:27092139

  18. Microchip screening platform for single cell assessment of NK cell cytotoxicity

    Directory of Open Access Journals (Sweden)

    Karolin eGuldevall

    2016-04-01

    Full Text Available Here we report a screening platform for assessment of the cytotoxic potential of individual natural killer (NK cells within larger populations. Human primary NK cells were distributed across a silicon-glass microchip containing 32 400 individual microwells loaded with target cells. Through fluorescence screening and automated image analysis the numbers of NK and live or dead target cells in each well could be assessed at different time points after initial mixing. Cytotoxicity was also studied by time-lapse live-cell imaging in microwells quantifying the killing potential of individual NK cells. Although most resting NK cells (≈75% were non-cytotoxic against the leukemia cell line K562, some NK cells were able to kill several (≥3 target cells within the 12 hours long experiment. In addition, the screening approach was adapted to increase the chance to find and evaluate serial killing NK cells. Even if the cytotoxic potential varied between donors it was evident that a small fraction of highly cytotoxic NK cells were responsible for a substantial portion of the killing. We demonstrate multiple assays where our platform can be used to enumerate and characterize cytotoxic cells, such as NK or T cells. This approach could find use in clinical applications, e.g. in the selection of donors for stem cell transplantation or generation of highly specific and cytotoxic cells for adoptive immunotherapy.

  19. Comparison of Unmanned Aerial Vehicle Platforms for Assessing Vegetation Cover in Sagebrush Steppe Ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Breckenridge; Maxine Dakins; Stephen Bunting; Jerry Harbour; Sera White

    2011-09-01

    In this study, the use of unmanned aerial vehicles (UAVs) as a quick and safe method for monitoring biotic resources was evaluated. Vegetation cover and the amount of bare ground are important factors in understanding the sustainability of many ecosystems and assessment of rangeland health. Methods that improve speed and cost efficiency could greatly improve how biotic resources are monitored on western lands. Sagebrush steppe ecosystems provide important habitat for a variety of species (including sage grouse and pygmy rabbit). Improved methods are needed to support monitoring these habitats because there are not enough resource specialists or funds available for comprehensive ground evaluations. In this project, two UAV platforms, fixed wing and helicopter, were used to collect still-frame imagery to assess vegetation cover in sagebrush steppe ecosystems. This paper discusses the process for collecting and analyzing imagery from the UAVs to (1) estimate percent cover for six different vegetation types (shrub, dead shrub, grass, forb, litter, and bare ground) and (2) locate sage grouse using representative decoys. The field plots were located on the Idaho National Engineering (INL) site west of Idaho Falls, Idaho, in areas with varying amounts and types of vegetation cover. A software program called SamplePoint was used along with visual inspection to evaluate percent cover for the six cover types. Results were compared against standard field measurements to assess accuracy. The comparison of fixed-wing and helicopter UAV technology against field estimates shows good agreement for the measurement of bare ground. This study shows that if a high degree of detail and data accuracy is desired, then a helicopter UAV may be a good platform to use. If the data collection objective is to assess broad-scale landscape level changes, then the collection of imagery with a fixed-wing system is probably more appropriate.

  20. The touchscreen operant platform for assessing cognitive functions in a rat model of depression.

    Science.gov (United States)

    Tran, Thao Phuong; Christensen, Helle Lyng; Bertelsen, Freja Cecilia Brandt; Bouzinova, Elena; Møller, Arne; Wiborg, Ove

    2016-07-01

    In the present study we assessed alterations in cognitive functions in a chronic mild stress (CMS) rat model of depression. Cognitive functions were assessed in two different tasks applying the translational operant platform touchscreen technology; the visual discrimination/acquisition task was used to assess the ability to perceive and distinguish visual stimuli and to assess associative stimulus-reward learning. The visual discrimination/reversal learning task was used to assess functional brain plasticity or reprogramming of previously acquired stimulus-reward associations. These tasks permit the dissociation of multiple cognitive domains. The CMS model is a validated depression model with the useful feature that rats upon stress exposure show a graduated, individual stress response allowing the segregation of rats into different phenotypes including stress-resilient and anhedonic-like subgroups. Anhedonic-like rats are less likely to acquire the pairwise discrimination task, and they have a slower acquisition rate than controls. In the reversal learning task, resilient rats performed significantly better than anhedonic-like rats over time and 50% passed criterion as opposed to 25% for controls and only 14% for anhedonic-like rats. This indicates that resilient rats have higher cognitive flexibility than anhedonic-like rats. Thus they perform better in learning a novel task, which at the same time potentially implies an increased ability to inhibit previously rewarded behavior. PMID:27083126

  1. I want what you've got: Cross platform portabiity and human-robot interaction assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Julie L. Marble, Ph.D.*.; Douglas A. Few; David J. Bruemmer

    2005-08-01

    Human-robot interaction is a subtle, yet critical aspect of design that must be assessed during the development of both the human-robot interface and robot behaviors if the human-robot team is to effectively meet the complexities of the task environment. Testing not only ensures that the system can successfully achieve the tasks for which it was designed, but more importantly, usability testing allows the designers to understand how humans and robots can, will, and should work together to optimize workload distribution. A lack of human-centered robot interface design, the rigidity of sensor configuration, and the platform-specific nature of research robot development environments are a few factors preventing robotic solutions from reaching functional utility in real word environments. Often the difficult engineering challenge of implementing adroit reactive behavior, reliable communication, trustworthy autonomy that combines with system transparency and usable interfaces is overlooked in favor of other research aims. The result is that many robotic systems never reach a level of functional utility necessary even to evaluate the efficacy of the basic system, much less result in a system that can be used in a critical, real-world environment. Further, because control architectures and interfaces are often platform specific, it is difficult or even impossible to make usability comparisons between them. This paper discusses the challenges inherent to the conduct of human factors testing of variable autonomy control architectures and across platforms within a complex, real-world environment. It discusses the need to compare behaviors, architectures, and interfaces within a structured environment that contains challenging real-world tasks, and the implications for system acceptance and trust of autonomous robotic systems for how humans and robots interact in true interactive teams.

  2. Analysis of snow-cap pollution for air quality assessment in the vicinity of an oil refinery.

    Science.gov (United States)

    Krastinyte, Viktorija; Baltrenaite, Edita; Lietuvninkas, Arvydas

    2013-01-01

    Snow-cap can be used as a simple and effective indicator of industrial air pollution. In this study snow-cap samples were collected from 11 sites located in the vicinity of an oil refinery in Mazeikiai, a region in the north-west of Lithuania, in the winter of 2011. Analysis of snowmelt water and snow-dust was used to determine anthropogenic pollutants such as: sulphates and chlorides, nitrites, nitrates, ammonium nitrogen, total carbon, total nitrogen; heavy metals: lead (Pb), copper (Cu), chromium (Cr), cadmium (Cd). Concentrations of heavy metals in snow-dust were detected thousands of times higher than those in the snowmelt water. In this study, analysis of heavy metal concentration was conducted considering different distances and the wind direction within the impact zone of the oil refinery. The sequence of heavy metals according to their mean concentrations in the snow-dust samples was the following: Pb > Cr > Cu > Cd. Heavy metals highly correlated among each other. The load of snow-dust was evaluated to determine the pollution level in the study area. The highest daily load of snow-dust was 45.81 +/- 12.35 mg/m2 in the north-western direction from the oil refinery. According to classification of the daily load of snow-dust a lower than medium-risk level of pollution was determined in the vicinity of the oil refinery.

  3. Tile-in-ONE: A web platform which integrates Tile Calorimeter data quality and calibration assessment

    CERN Document Server

    Sivolella Gomes, Andressa; The ATLAS collaboration; Maidantchik, Carmen; Solans, Carlos; Burghgrave, Blake; Solodkov, Alexander

    2015-01-01

    The ATLAS Tile Calorimeter assesses the quality of data in order to ensure its proper operation. A number of tasks are then performed by running several tools and systems, which were independently developed to meet distinct collaboration’s requirements and do not necessarily builds an effective connection among them. Thus, a program is usually implemented without a global perspective of the detector, requiring basic software features. In addition, functionalities may overlap in their objectives and frequently replicate resources retrieval mechanisms. Tile-in-ONE is a unique platform that assembles various web systems used by the calorimeter community through a single framework and a standard technology. It provides an infrastructure to support the code implementation, avoiding duplication of work while integrating with an overall view of the detector status. Database connectors smooth the process of information access since developers do not need to be aware of where records are placed and how to extract th...

  4. The SAMCO Web-platform for resilience assessment in mountainous valleys impacted by landslide risks.

    Science.gov (United States)

    Grandjean, Gilles; Thomas, Loic; Bernardie, Severine

    2016-04-01

    The ANR-SAMCO project aims to develop a proactive resilience framework enhancing the overall resilience of societies on the impacts of mountain risks. The project aims to elaborate methodological tools to characterize and measure ecosystem and societal resilience from an operative perspective on three mountain representative case studies. To achieve this objective, the methodology is split in several points: (1) the definition of the potential impacts of global environmental changes (climate system, ecosystem e.g. land use, socio-economic system) on landslide hazards, (2) the analysis of these consequences in terms of vulnerability (e.g. changes in the location and characteristics of the impacted areas and level of their perturbation) and (3) the implementation of a methodology for quantitatively investigating and mapping indicators of mountain slope vulnerability exposed to several hazard types, and the development of a GIS-based demonstration platform available on the web. The strength and originality of the SAMCO project lies in the combination of different techniques, methodologies and models (multi-hazard assessment, risk evolution in time, vulnerability functional analysis, and governance strategies) that are implemented in a user-oriented web-platform, currently in development. We present the first results of this development task, architecture and functions of the web-tools, the case studies database showing the multi-hazard maps and the stakes at risks. Risk assessment over several area of interest in Alpine or Pyrenean valleys are still in progress, but the first analyses are presented for current and future periods for which climate change and land-use (economical, geographical and social aspects) scenarios are taken into account. This tool, dedicated to stakeholders, should be finally used to evaluate resilience of mountainous regions since multiple scenarios can be tested and compared.

  5. MOSFET assessment of radiation dose delivered to mice using the Small Animal Radiation Research Platform (SARRP).

    Science.gov (United States)

    Ngwa, Wilfred; Korideck, Houari; Chin, Lee M; Makrigiorgos, G Mike; Berbeco, Ross I

    2011-12-01

    The Small Animal Radiation Research Platform (SARRP) is a novel isocentric irradiation system that enables state-of-the-art image-guided radiotherapy research to be performed with animal models. This paper reports the results obtained from investigations assessing the radiation dose delivered by the SARRP to different anatomical target volumes in mice. Surgically implanted metal oxide semiconductor field effect transistors (MOSFET) dosimeters were employed for the dose assessment. The results reveal differences between the calculated and measured dose of -3.5 to 0.5%, -5.2 to -0.7%, -3.9 to 0.5%, -5.9 to 2.5%, -5.5 to 0.5%, and -4.3 to 0% for the left kidney, liver, pancreas, prostate, left lung, and brain, respectively. Overall, the findings show less than 6% difference between the delivered and calculated dose, without tissue heterogeneity corrections. These results provide a useful assessment of the need for tissue heterogeneity corrections in SARRP dose calculations for clinically relevant tumor model sites. PMID:21962005

  6. The EnerGEO Platform of Integrated Assessment (PIA). Environmental assessment of scenarios as a web service

    International Nuclear Information System (INIS)

    With the International Energy Agency estimating that global energy demand will increase between 40 and 50 percent by 2030 (compared to 2003), scientists and policymakers are concerned about the sustainability of the current energy system and what environmental pressures might result from the development of future energy systems. EnerGEO is an ongoing FP7 Project (2009-2013) which assesses the current and future impact of energy use on the environment by linking environmental observation systems with the processes involved in exploiting energy resources. The idea of this European project is to determine how low carbon scenarios, and in particular scenarios with a high share of renewable electricity, affect emissions of air pollutants and greenhouse gases (GHG) and contribute to mitigation of negative energy system impacts on human health and ecosystems. A Platform of Integrated Assessment (PIA) has been elaborated to provide impact results for a selection of scenarios via a set of models (large-scale energy models, Life Cycle Assessment models,..). This PIA is currently available through a web service. The concept of the PIA is detailed and to illustrate its interest, a set of results is given with the use of the simulation mode of the European version of GAINS for a selection of scenarios. (orig.)

  7. Seismic hazard and risk assessment for large Romanian dams situated in the Moldavian Platform

    Science.gov (United States)

    Moldovan, Iren-Adelina; Popescu, Emilia; Otilia Placinta, Anica; Petruta Constantin, Angela; Toma Danila, Dragos; Borleanu, Felix; Emilian Toader, Victorin; Moldoveanu, Traian

    2016-04-01

    Besides periodical technical inspections, the monitoring and the surveillance of dams' related structures and infrastructures, there are some more seismic specific requirements towards dams' safety. The most important one is the seismic risk assessment that can be accomplished by rating the dams into seismic risk classes using the theory of Bureau and Ballentine (2002), and Bureau (2003), taking into account the maximum expected peak ground motions at the dams site - values obtained using probabilistic hazard assessment approaches (Moldovan et al., 2008), the structures vulnerability and the downstream risk characteristics (human, economical, historic and cultural heritage, etc) in the areas that might be flooded in the case of a dam failure. Probabilistic seismic hazard (PSH), vulnerability and risk studies for dams situated in the Moldavian Platform, starting from Izvorul Muntelui Dam, down on Bistrita and following on Siret River and theirs affluent will be realized. The most vulnerable dams will be studied in detail and flooding maps will be drawn to find the most exposed downstream localities both for risk assessment studies and warnings. GIS maps that clearly indicate areas that are potentially flooded are enough for these studies, thus giving information on the number of inhabitants and goods that may be destroyed. Geospatial servers included topography is sufficient to achieve them, all other further studies are not necessary for downstream risk assessment. The results will consist of local and regional seismic information, dams specific characteristics and locations, seismic hazard maps and risk classes, for all dams sites (for more than 30 dams), inundation maps (for the most vulnerable dams from the region) and possible affected localities. The studies realized in this paper have as final goal to provide the local emergency services with warnings of a potential dam failure and ensuing flood as a result of an large earthquake occurrence, allowing further

  8. Cancer risk assessment for Tehran research reactor and radioisotope laboratory with CAP88-PC code (Gaussian plume model)

    International Nuclear Information System (INIS)

    Research highlights: → Impact of Tehran's reactor and radioisotope laboratory stacks has been studied. → Gaussian Plume Dispersion Model and laboratory analyses were used. → Glass-fiber filters were used in the exclusion area in different direction. → The released radionuclide concentration was calculated by the code and measurements. → Dose calculations best compared to procedures presented in the Regulatory Guide. - Abstract: The amount of released radionuclide from Tehran's research reactor and radioisotope laboratory stacks and their impact have been studied. The aim of this work is to determine the amount and type of radioactive materials and to estimate their risk once they are released into the environment. To perform the above two tasks, CAP88-PC computer code which simulates Gaussian dispersion air transport Plume Model and laboratory analysis of air samples around the site were used. Computer code input data are provided by the Safety Analysis Report and Reactor Annual Reports. Air samples were collected using the filter and sampling pumps and analyzed by gamma spectroscopy counter. Results of computer program showed that the risk of cancer death (lifetime risk) is below the regulatory limit. Results of analysis of available radionuclide in the air samples also showed that concentrations are close to the background and confirm the code results.

  9. Accuracy Assessment of Direct Georeferencing for Photogrammetric Applications on Small Unmanned Aerial Platforms

    Science.gov (United States)

    Mian, O.; Lutes, J.; Lipa, G.; Hutton, J. J.; Gavelle, E.; Borghini, S.

    2016-03-01

    Microdrones md4-1000 quad-rotor VTOL UAV. The Sony A7R and each lens combination were focused and calibrated terrestrially using the Applanix camera calibration facility, and then integrated with the APX-15 GNSS-Inertial system using a custom mount specifically designed for UAV applications. The mount is constructed in such a way as to maintain the stability of both the interior orientation and IMU boresight calibration over shock and vibration, thus turning the Sony A7R into a metric imaging solution. In July and August 2015, Applanix and Avyon carried out a series of test flights of this system. The goal of these test flights was to assess the performance of DMS APX-15 direct georeferencing system under various scenarios. Furthermore, an examination of how DMS APX-15 can be used to produce accurate map products without the use of ground control points and with reduced sidelap was also carried out. Reducing the side lap for survey missions performed by small UAVs can significantly increase the mapping productivity of these platforms. The area mapped during the first flight campaign was a 250m x 300m block and a 775m long railway corridor in a rural setting in Ontario, Canada. The second area mapped was a 450m long corridor over a dam known as Fryer Dam (over Richelieu River in Quebec, Canada). Several ground control points were distributed within both test areas. The flight over the block area included 8 North-South lines and 1 cross strip flown at 80m AGL, resulting in a ~1cm GSD. The flight over the railway corridor included 2 North-South lines also flown at 80m AGL. Similarly, the flight over the dam corridor included 2 North-South lines flown at 50m AGL. The focus of this paper was to analyse the results obtained from the two corridors. Test results from both areas were processed using Direct Georeferencing techniques, and then compared for accuracy against the known positions of ground control points in each test area. The GNSS-Inertial data collected by the APX-15 was

  10. Assessment of undiscovered oil and gas resources in the Cherokee Platform Province area of Kansas, Oklahoma, and Missouri, 2015

    Science.gov (United States)

    Drake II, Ronald M.; Hatch, Joseph R.; Schenk, Christopher J.; Charpentier, Ronald R.; Klett, Timothy R.; Le, Phuong A.; Leathers, Heidi M.; Brownfield, Michael E.; Gaswirth, Stephanie B.; Marra, Kristen R.; Pitman, Janet K.; Potter, Christopher J.; Tennyson, Marilyn E.

    2015-01-01

    Using a geology-based assessment methodology, the U.S. Geological Survey estimated mean volumes of undiscovered, technically recoverable resources of 463 million barrels of oil, 11.2 trillion cubic feet of gas, and 35 million barrels of natural gas liquids in the Cherokee Platform Province area of Kansas, Oklahoma, and Missouri.

  11. Comprehensive risk assessment for rail transportation of dangerous goods: a validated platform for decision support

    International Nuclear Information System (INIS)

    Currently, the most advanced and well documented risk assessments for the transportation of dangerous goods by railway take into account:(i)statistics-based loss of containment frequencies, (ii) specification of potential consequences for a given release situations using event tree methodology as an organisational tool and (iii) consequence calculation models to determine a risk figure known as CCDF (Complementary Cumulative Distribution Function). Such procedures for the risk assessment (including for example decision-making on preventive measures) may offer only a limited insight into the causes and sequences leading to an accident and do not allow for any kind of predictive analysis. The present work introduces an enhanced solution, and a related software platform, which attempts to integrate loss of containment causes and consequences with system's infrastructure and its environment. The solution features:(i)the use of a detailed Master Logical Diagram, including fault/event tree analysis to determine a loss of containment frequency based on different initiating events, scenarios and specific basic data, (ii) the characterization of a resulting source term following a release situation, and (iii) the calculation of various potential impacts on the neighbouring site. Results are wrapped into a CCDF format for each selected traffic segment. The risk-related results are integrated on a software platform, structured as a decision support system using intelligent maps and a variety of GIS (Geographical Information System) data processing procedures. The introduction of the hot spot approach, allows us to focus on the most risk-relevant areas and to use information on various railway infrastructure elements (e.g. points, tunnels), are the basis of the new models employed. The software is applicable to any railway transportation system, comprising its technical infrastructure, rolling stock, human actions, regulation and management procedures. It provides the

  12. Postural Stability Assessment of University Marching Musicians Using Force Platform Measures.

    Science.gov (United States)

    Magnotti, Trevor D; McElhiney, Danielle; Russell, Jeffrey A

    2016-09-01

    Lower extremity injury is prevalent in marching musicians, and poor postural stability is a possible risk factor for this. The external load of an instrument may predispose these performers to injury by decreasing postural stability. The purpose of this study was to determine the relationship between instrument load and static and dynamic postural stability in this population. Fourteen university marching musicians were recruited and completed a balance assessment protocol on a force platform with and without their instrument. Mean center of pressure (CoP) displacement was then calculated for each exercise in the anterior/posterior and medial/lateral planes. Mean anterior/posterior CoP displacement significantly increased in the instrument condition for the static surface, eyes closed, 2 feet condition (p≤0.005; d=0.89). No significant differences were found in the medial/lateral plane between non-instrument and instrument conditions. Significant differences were not found between test stance conditions independent of group. Comparisons between the non-instrument-loaded and instrument-loaded conditions revealed possible significance of instrument load on postural stability in the anterior/posterior plane. Mean differences indicated that an unstable surface created a greater destabilizing effect on postural stability than instrument load. PMID:27575294

  13. A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

    Science.gov (United States)

    Koopman, Mandy; Michels, Helen; Dancy, Beverley M; Kamble, Rashmi; Mouchiroud, Laurent; Auwerx, Johan; Nollen, Ellen A A; Houtkooper, Riekelt H

    2016-10-01

    Mitochondrial dysfunction is at the core of many diseases ranging from inherited metabolic diseases to common conditions that are associated with aging. Although associations between aging and mitochondrial function have been identified using mammalian models, much of the mechanistic insight has emerged from Caenorhabditis elegans. Mitochondrial respiration is recognized as an indicator of mitochondrial health. The Seahorse XF96 respirometer represents the state-of-the-art platform for assessing respiration in cells, and we adapted the technique for applications involving C. elegans. Here we provide a detailed protocol to optimize and measure respiration in C. elegans with the XF96 respirometer, including the interpretation of parameters and results. The protocol takes ∼2 d to complete, excluding the time spent culturing C. elegans, and it includes (i) the preparation of C. elegans samples, (ii) selection and loading of compounds to be injected, (iii) preparation and execution of a run with the XF96 respirometer and (iv) postexperimental data analysis, including normalization. In addition, we compare our XF96 application with other existing techniques, including the eight-well Seahorse XFp. The main benefits of the XF96 include the limited number of worms required and the high throughput capacity due to the 96-well format.

  14. Development of a Micro-UAV Hyperspectral Imaging Platform for Assessing Hydrogeological Hazards

    Science.gov (United States)

    Chen, Z.; Alabsi, M.

    2015-12-01

    The exacerbating global weather changes have cast significant impacts upon the proportion of water supplied to agriculture. Therefore, one of the 21stCentury Grant Challenges faced by global population is securing water for food. However, the soil-water behavior in an agricultural environment is complex; among others, one of the key properties we recognize is water repellence or hydrophobicity, which affects many hydrogeological and hazardous conditions such as excessive water infiltration, runoff, and soil erosion. Under a US-Israel research program funded by USDA and BARD at Israel, we have proposed the development of a novel micro-unmanned aerial vehicle (micro-UAV or drone) based hyperspectral imaging platform for identifying and assessing soil repellence at low altitudes with enhanced flexibility, much reduced cost, and ultimately easy use. This aerial imaging system consists of a generic micro-UAV, hyperspectral sensor aided by GPS/IMU, on-board computing units, and a ground station. The target benefits of this system include: (1) programmable waypoint navigation and robotic control for multi-view imaging; (2) ability of two- or three-dimensional scene reconstruction for complex terrains; and (3) fusion with other sensors to realize real-time diagnosis (e.g., humidity and solar irradiation that may affect soil-water sensing). In this talk we present our methodology and processes in integration of hyperspectral imaging, on-board sensing and computing, hyperspectral data modeling, and preliminary field demonstration and verification of the developed prototype.

  15. A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

    Science.gov (United States)

    Koopman, Mandy; Michels, Helen; Dancy, Beverley M; Kamble, Rashmi; Mouchiroud, Laurent; Auwerx, Johan; Nollen, Ellen A A; Houtkooper, Riekelt H

    2016-10-01

    Mitochondrial dysfunction is at the core of many diseases ranging from inherited metabolic diseases to common conditions that are associated with aging. Although associations between aging and mitochondrial function have been identified using mammalian models, much of the mechanistic insight has emerged from Caenorhabditis elegans. Mitochondrial respiration is recognized as an indicator of mitochondrial health. The Seahorse XF96 respirometer represents the state-of-the-art platform for assessing respiration in cells, and we adapted the technique for applications involving C. elegans. Here we provide a detailed protocol to optimize and measure respiration in C. elegans with the XF96 respirometer, including the interpretation of parameters and results. The protocol takes ∼2 d to complete, excluding the time spent culturing C. elegans, and it includes (i) the preparation of C. elegans samples, (ii) selection and loading of compounds to be injected, (iii) preparation and execution of a run with the XF96 respirometer and (iv) postexperimental data analysis, including normalization. In addition, we compare our XF96 application with other existing techniques, including the eight-well Seahorse XFp. The main benefits of the XF96 include the limited number of worms required and the high throughput capacity due to the 96-well format. PMID:27583642

  16. An integrated telemedicine platform for the assessment of affective physiological states

    Directory of Open Access Journals (Sweden)

    Ganiatsas George

    2006-08-01

    Full Text Available Abstract AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a a multisensorial wearable, (b a data acquisition and wireless communication module, (c a feature extraction module, (d a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model; whereas the end-user will be able to view the facial expression of the subject in real time, (e an intelligent emotion recognition module, and (f the AUBADE databases where the acquired signals along with the subject's animation videos are saved. The system is designed to be applied to human subjects operating under extreme stress conditions, in particular car racing drivers, and also to patients suffering from neurological and psychological disorders. AUBADE's classification accuracy into five predefined emotional classes (high stress, low stress, disappointment, euphoria and neutral face is 86.0%. The pilot system applications and components are being tested and evaluated on Maserati's car. racing drivers.

  17. Evaporites on Ice: Experimental Assessment of Evaporites Formation on Antarctica (and on Martian North Polar Residual Cap)

    Science.gov (United States)

    Losiak, Anna; Derkowski, Arkadiusz; Skala, Aleksander; Trzcinski, Jerzy

    2016-04-01

    Evaporites are highly water soluble minerals, formed as a result of the evaporation or freezing of bodies of water. They are common weathering minerals found on rocks (including meteorites) on Antarctic ice sheet [1,2,3,4]. The water necessary for the reaction is produced by melting of ice below the dark-colored meteorites which can heat up to a few degrees above 0 °C due to insolation heating during wind-free summer days [5,6]. The Martian North Polar Residual Cap is surrounded by a young [7] dune field that is rich in evaporitic mineral: gypsum [8]. Its existence implies that relatively recently in the Martian history (in late Amazonian, when surface conditions were comparable to the current ones) there was a significant amount of liquid water present on the Mars surface. One of the proposed solutions to this problem is that gypsum is formed by weathering on/in ice [9,10,11,12,13], similarly to the process occurring on the Antarctic ice sheet. Recently, Losiak et al. 2015 showed that that during the warmest days of the Martian summer, solar irradiation may be sufficient to melt pure water ice located below a layer of dark dust particles lying on the steepest sections of the equator-facing slopes of the spiral troughs within Martian NPRC. Under the current irradiation conditions, melting is possible in very restricted areas of the NPRC and it lasts for up to couple of hours, but during the times of high irradiance at the north pole [15] this process could have been much more pronounced. Liquid water can be metastable at the NPRC because the pressure during the summer season is ~760-650 Pa [16] which is above the triple point of water. The rate of free-surface "clean" liquid water evaporation under average Martian conditions determined experimentally by [17] is comparable to the rate of melting determined by [21] (if there is no wind at the surface). In the current study we attempt to determine experimentally how many melting-freezing cycles are required to form

  18. Towards Supporting Climate Scientists and Impact Assessment Analysts with the Big Data Europe Platform

    Science.gov (United States)

    Klampanos, Iraklis; Vlachogiannis, Diamando; Andronopoulos, Spyros; Cofiño, Antonio; Charalambidis, Angelos; Lokers, Rob; Konstantopoulos, Stasinos; Karkaletsis, Vangelis

    2016-04-01

    The EU, Horizon 2020, project Big Data Europe (BDE) aims to support European companies and institutions in effectively managing and making use of big data in activities critical to their progress and success. BDE focuses on seven areas of societal impact: Health, Food and Agriculture, Energy, Transport, Climate, Social Sciences and Security. By reaching out to partners and stakeholders, BDE aims to elicit data-intensive requirements for, and deliver an ICT platform to cover aspects of publishing and consuming semantically interoperable, large-scale, multi-lingual data assets and knowledge. In this presentation we will describe the first BDE pilot for Climate, focusing on SemaGrow, its core component, which provides data querying and management based on data semantics. Over the last few decades, extended scientific effort in understanding climate change has resulted in a huge volume of model and observational data. Large international global and regional model inter-comparison projects have focused on creating a framework in support of climate model diagnosis, validation, documentation and data access. The application of climate model ensembles, a system consisting of different possible realisations of a climate model, has further significantly increased the amount of climate and weather data generated. The provision of such models satisfies the crucial objective of assessing potential impacts of climate change on well-being for adaptation, prevention and mitigation. One of the methodologies applied by the climate research and impact assessment communities is that of dynamical downscaling. This calculates values of atmospheric variables in smaller spatial and temporal scales, given a global model. On the company or institution level, this process can be greatly improved in terms of querying, data ingestion from various sources and formats, automatic data mapping, etc. The first Climate BDE pilot will facilitate the process of dynamical downscaling by providing a

  19. Technology assessment for an integrated PC-based platform for three telemedicine applications

    Science.gov (United States)

    Tohme, Walid G.; Hayes, Wendelin S.; Dai, Hailei L.; Komo, Darmadi; Pahira, John J.; Abernethy, Darrell R.; Rennert, Wolfgang; Kuehl, Karen S.; Hauser, Gabriel J.; Mun, Seong K.

    1996-05-01

    This paper investigates the design and technical efficacy of an integrated PC based platform for three different medical applications. The technical efficacy of such a telemedicine platform has not been evaluated in the literature and optimal technical requirements have not been developed. The first application, with the Department of Surgery, Division of Urology, tests the utility of a telemedicine platform including radiology images for a surgical stone disease consultation service from an off site location in West Virginia. The second application, with the Department of Internal Medicine, Division of Clinical Pharmacology, investigates the usefulness of telemedicine when used for a clinical pharmacology consultation service from an off-site location. The third application, with the Department of Pediatrics, will test telemedicine for trauma care triage service first within an off-site location in Virginia and then from there to Georgetown University Medical Center.

  20. Assessment of the real-time PCR and different digital PCR platforms for DNA quantification

    OpenAIRE

    Pavšič, Jernej; Žel, Jana; Milavec, Mojca

    2015-01-01

    Digital PCR (dPCR) is beginning to supersede real-time PCR (qPCR) for quantification of nucleic acids in many different applications. Several analytical properties of the two most commonly used dPCR platforms, namely the QX100 system (Bio-Rad) and the 12.765 array of the Biomark system (Fluidigm), have already been evaluated and compared with those of qPCR. However, to the best of our knowledge, direct comparison between the three of these platforms using the same DNA material has not been do...

  1. Microtubule's conformational cap

    DEFF Research Database (Denmark)

    Chretien, D.; Janosi, I.; Taveau, J.C.;

    1999-01-01

    The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called "GTP-cap". Here, we point-out that the elastic properties...

  2. Hybrid causal methodology and software platform for probabilistic risk assessment and safety monitoring of socio-technical systems

    International Nuclear Information System (INIS)

    This paper introduces an integrated framework and software platform for probabilistic risk assessment (PRA) and safety monitoring of complex socio-technical systems. An overview of the three-layer hybrid causal logic (HCL) modeling approach and corresponding algorithms, implemented in the Trilith software platform, are provided. The HCL approach enhances typical PRA methods by quantitatively including the influence of soft causal factors introduced by human and organizational aspects of a system. The framework allows different modeling techniques to be used for different aspects of the socio-technical system. The HCL approach combines the power of traditional event sequence diagram (ESD)event tree (ET) and fault tree (FT) techniques for modeling deterministic causal paths, with the flexibility of Bayesian belief networks for modeling non-deterministic cause-effect relationships among system elements (suitable for modeling human and organizational influences). Trilith enables analysts to construct HCL models and perform quantitative risk assessment and management of complex systems. The risk management capabilities included are HCL-based risk importance measures, hazard identification and ranking, precursor analysis, safety indicator monitoring, and root cause analysis. This paper describes the capabilities of the Trilith platform and power of the HCL algorithm by use of example risk models for a type of aviation accident (aircraft taking off from the wrong runway).

  3. Whole-body isometric force/torque measurements for functional assessment in neuro-rehabilitation: platform design, development and verification

    Directory of Open Access Journals (Sweden)

    Cavallo Giuseppe

    2009-10-01

    Full Text Available Abstract Background One of the main scientific and technological challenges of rehabilitation bioengineering is the development of innovative methodologies, based on the use of appropriate technological devices, for an objective assessment of patients undergoing a rehabilitation treatment. Such tools should be as fast and cheap to use as clinical scales, which are currently the daily instruments most widely used in the routine clinical practice. Methods A human-centered approach was used in the design and development of a mechanical structure equipped with eight force/torque sensors that record quantitative data during the initiation of a predefined set of Activities of Daily Living (ADL tasks, in isometric conditions. Results Preliminary results validated the appropriateness, acceptability and functionality of the proposed platform, that has become now a tool used for clinical research in three clinical centres. Conclusion This paper presented the design and development of an innovative platform for whole-body force and torque measurements on human subjects. The platform has been designed to perform accurate quantitative measurements in isometric conditions with the specific aim to address the needs for functional assessment tests of patients undergoing a rehabilitation treatment as a consequence of a stroke. The versatility of the system also enlightens several other interesting possible areas of application for therapy in neurorehabilitation, for research in basic neuroscience, and more.

  4. GPS/CAPS dual-mode software receiver

    Institute of Scientific and Technical Information of China (English)

    NING ChunLin; SHI HuLi; HU Chao

    2009-01-01

    The positioning of the GPS or Chinese Area Positioning System (CAPS) software receiver was developed on a software receiver platform.The structure of the GPSlCAPS dual-mode software receiver was put forward after analyzing the differences in the satellite identification,ranging code,spread spectrum,coordinate system,time system,carrier band,and navigation data between GPS and CAPS.Based on Matlab software on a personal computer,baseband signal processing and positioning procedures were completed using real GPS and CAPS radio frequency signals received by two antennas.Three kinds of experiments including GPS positioning,CAPS positioning,and GPS/CAPS positioning were carried out.Stability and precision of the results were analyzed and compared.The experimental results show that the precision of CAPS is similar to that of GPS,while the positioning precision of the GPS/CAPS dual-mode software receiver is 1-2 m higher than that of CAPS or GPS.The smallest average variance of the positioning can be obtained by using the GPS/CAPS dual-mode software receiver.

  5. GPS/CAPS dual-mode software receiver

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The positioning of the GPS or Chinese Area Positioning System (CAPS) software receiver was developed on a software receiver platform. The structure of the GPS/CAPS dual-mode software receiver was put forward after analyzing the differences in the satellite identification, ranging code, spread spectrum, coordinate system, time system, carrier band, and navigation data between GPS and CAPS. Based on Matlab software on a personal computer, baseband signal processing and positioning procedures were completed using real GPS and CAPS radio frequency signals received by two antennas. Three kinds of experiments including GPS positioning, CAPS positioning, and GPS/CAPS positioning were carried out. Stability and precision of the results were analyzed and compared. The experimental results show that the precision of CAPS is similar to that of GPS, while the positioning precision of the GPS/CAPS dual-mode software receiver is 1-2 m higher than that of CAPS or GPS. The smallest average variance of the positioning can be obtained by using the GPS/CAPS dual-mode software receiver.

  6. Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases

    Institute of Scientific and Technical Information of China (English)

    Tan Jiping; Li Nan; Gao Jing; Guo Yuhe; Hu Wei; Yang Jinsheng; Yu Baocheng

    2014-01-01

    Background Based on the excellent medical care and management system for Chinese veterans,as well as the detailed medical documentation available,we aim to construct a Chinese Veteran Clinical Research (CVCR) platform on noncommunicable diseases (NCDs) and carry out studies of the primary disabling NCDs.Methods The Geriatric Neurology Department of Chinese People's Liberation Army General Hospital and veterans' hospitals serve as the leading and participating units in the platform construction.The fundamental constituents of the platform are veteran communities.Stratified typical cluster sampling is adopted to recruit veteran communities.A cross-sectional study of mental,neurological,and substance use (MNS) disorders are performed in two stages using screening scale such as the Mini-Mental State Examination and Montreal cognitive assessment,followed by systematic neuropsychological assessments to make clinical diagnoses,evaluated disease awareness and care situation.Results A total of 9 676 among 277 veteran communities from 18 cities are recruited into this platform,yielding a response rate of 83.86%.8 812 subjects complete the MNS subproject screening and total response rate is 91.70%.The average participant age is (82.01±4.61) years,69.47% of veterans are 80 years or older.Most participants are male (94.01%),83.36% of subjects have at least a junior high school degree.The overall health status of veterans is good and stable.The most common NCD are cardiovascular disorders (86.44%),urinary and genital diseases (73.14%),eye and ear problems (66.25%),endocrine (56.56%) and neuro-psychiatric disturbances (50.78%).Conclusion We first construct a veterans' comprehensive clinical research platform for the study of NCDs that is primarily composed of highly educated Chinese males of advanced age and utilize this platform to complete a cross-sectional national investigation of MNS disorders among veterans.The good and stable health condition of the

  7. UNDERSTANDING FARMERS’ RESPONSES TO CAP REFORM

    OpenAIRE

    Menozzi, Davide; Fioravanzi, Martina; Donati, Michele

    2014-01-01

    The 2014-2020 Common Agricultural Policy (CAP) reform defines new rules for farmers including regionalization, crop diversification and ecological focus area (EFA). This paper aims to evaluate farmers’ intention to modify their behaviour because of the CAP reform, using the Theory of Planned Behaviour (TPB). A questionnaire was submitted to 71 Italian durum wheat producers assessing their intention to change durum wheat surface and to maintain as EFA part of the arable land. Subjective norms ...

  8. Generation and functional assessment of 3D multicellular spheroids in droplet based microfluidics platform.

    Science.gov (United States)

    Sabhachandani, P; Motwani, V; Cohen, N; Sarkar, S; Torchilin, V; Konry, T

    2016-02-01

    Here we describe a robust, microfluidic technique to generate and analyze 3D tumor spheroids, which resembles tumor microenvironment and can be used as a more effective preclinical drug testing and screening model. Monodisperse cell-laden alginate droplets were generated in polydimethylsiloxane (PDMS) microfluidic devices that combine T-junction droplet generation and external gelation for spheroid formation. The proposed approach has the capability to incorporate multiple cell types. For the purposes of our study, we generated spheroids with breast cancer cell lines (MCF-7 drug sensitive and resistant) and co-culture spheroids of MCF-7 together with a fibroblast cell line (HS-5). The device has the capability to house 1000 spheroids on chip for drug screening and other functional analysis. Cellular viability of spheroids in the array part of the device was maintained for two weeks by continuous perfusion of complete media into the device. The functional performance of our 3D tumor models and a dose dependent response of standard chemotherapeutic drug, doxorubicin (Dox) and standard drug combination Dox and paclitaxel (PCT) was analyzed on our chip-based platform. Altogether, our work provides a simple and novel, in vitro platform to generate, image and analyze uniform, 3D monodisperse alginate hydrogel tumors for various omic studies and therapeutic efficiency screening, an important translational step before in vivo studies. PMID:26686985

  9. Wearable textile platform for assessing stroke patient treatment in daily life conditions

    Directory of Open Access Journals (Sweden)

    Federico eLorussi

    2016-03-01

    Full Text Available Monitoring physical activities during post-stroke rehabilitation in daily life may help physicians to optimize and tailor the training program for patients. The European research project INTERACTION (FP7-ICT-2011-7-287351 evaluated motor capabilities in stroke patients during the recovery treatment period. We developed wearable sensing platform based on the sensor fusion among inertial, knitted piezoresistive sensors and textile EMG electrodes . The device was conceived in modular form and consists of a separate shirt, trousers, glove and shoe. Thanks to the novel fusion approach it has been possible to develop a model for the shoulder taking into account the scapulo-thoracic joint of the scapular girdle, considerably improving the estimation of the hand position in reaching activities. In order to minimize the sensor set used to monitor gait, a single inertial sensor fused with a textile goniometer proved to reconstruct the orientation of all the body segments of the leg. Finally, the sensing glove, endowed with three textile goniometers and three force sensors showed good capabilities in the reconstruction of grasping activities and evaluating the interaction of the hand with the environment, according to the project specifications. This paper reports on the design and the technical evaluation of the performance of the sensing platform, tested on healthy subjects.

  10. Wearable Textile Platform for Assessing Stroke Patient Treatment in Daily Life Conditions.

    Science.gov (United States)

    Lorussi, Federico; Carbonaro, Nicola; De Rossi, Danilo; Paradiso, Rita; Veltink, Peter; Tognetti, Alessandro

    2016-01-01

    Monitoring physical activities during post-stroke rehabilitation in daily life may help physicians to optimize and tailor the training program for patients. The European research project INTERACTION (FP7-ICT-2011-7-287351) evaluated motor capabilities in stroke patients during the recovery treatment period. We developed wearable sensing platform based on the sensor fusion among inertial, knitted piezoresistive sensors and textile EMG electrodes. The device was conceived in modular form and consists of a separate shirt, trousers, glove, and shoe. Thanks to the novel fusion approach it has been possible to develop a model for the shoulder taking into account the scapulo-thoracic joint of the scapular girdle, considerably improving the estimation of the hand position in reaching activities. In order to minimize the sensor set used to monitor gait, a single inertial sensor fused with a textile goniometer proved to reconstruct the orientation of all the body segments of the leg. Finally, the sensing glove, endowed with three textile goniometers and three force sensors showed good capabilities in the reconstruction of grasping activities and evaluating the interaction of the hand with the environment, according to the project specifications. This paper reports on the design and the technical evaluation of the performance of the sensing platform, tested on healthy subjects. PMID:27047939

  11. Wearable Textile Platform for Assessing Stroke Patient Treatment in Daily Life Conditions.

    Science.gov (United States)

    Lorussi, Federico; Carbonaro, Nicola; De Rossi, Danilo; Paradiso, Rita; Veltink, Peter; Tognetti, Alessandro

    2016-01-01

    Monitoring physical activities during post-stroke rehabilitation in daily life may help physicians to optimize and tailor the training program for patients. The European research project INTERACTION (FP7-ICT-2011-7-287351) evaluated motor capabilities in stroke patients during the recovery treatment period. We developed wearable sensing platform based on the sensor fusion among inertial, knitted piezoresistive sensors and textile EMG electrodes. The device was conceived in modular form and consists of a separate shirt, trousers, glove, and shoe. Thanks to the novel fusion approach it has been possible to develop a model for the shoulder taking into account the scapulo-thoracic joint of the scapular girdle, considerably improving the estimation of the hand position in reaching activities. In order to minimize the sensor set used to monitor gait, a single inertial sensor fused with a textile goniometer proved to reconstruct the orientation of all the body segments of the leg. Finally, the sensing glove, endowed with three textile goniometers and three force sensors showed good capabilities in the reconstruction of grasping activities and evaluating the interaction of the hand with the environment, according to the project specifications. This paper reports on the design and the technical evaluation of the performance of the sensing platform, tested on healthy subjects.

  12. Assessing lahars from ice-capped volcanoes using ASTER satellite data, the SRTM DTM and two different flow models: case study on Iztaccíhuatl (Central Mexico

    Directory of Open Access Journals (Sweden)

    D. Schneider

    2008-06-01

    Full Text Available Lahars frequently affect the slopes of ice-capped volcanoes. They can be triggered by volcano-ice interactions during eruptions but also by processes such as intense precipitation or by outbursts of glacial water bodies not directly related to eruptive activity. We use remote sensing, GIS and lahar models in combination with ground observations for an initial lahar hazard assessment on Iztaccíhuatl volcano (5230 m a.s.l., considering also possible future developments of the glaciers on the volcano. Observations of the glacial extent are important for estimations of future hazard scenarios, especially in a rapidly changing tropical glacial environment. In this study, analysis of the glaciers on Iztaccíhuatl shows a dramatic retreat during the last 150 years: the glaciated area in 2007 corresponds to only 4% of the one in 1850 AD and the glaciers are expected to survive no later than the year 2020. Most of the glacial retreat is considered to be related to climate change but in-situ observations suggest also that geo- and hydrothermal heat flow at the summit-crater area can not be ruled out, as emphasized by fumarolic activity documented in a former study. However, development of crater lakes and englacial water reservoirs are supposed to be a more realistic scenario for lahar generation than sudden ice melting by rigorous volcano-ice interaction. Model calculations show that possible outburst floods have to be larger than ~5×105 m3 or to achieve an H/L ratio (Height/runout Length of 0.2 and lower in order to reach the populated lower flanks. This threshold volume equals 2.4% melted ice of Iztaccíhuatl's total ice volume in 2007, assuming 40% water and 60% volumetric debris content of a potential lahar. The model sensitivity analysis reveals important effects of the generic type of the Digital Terrain Model (DTM used on the results. As a consequence, the predicted affected areas can vary significantly. For such

  13. Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment

    Directory of Open Access Journals (Sweden)

    Andrew J. Percy

    2015-09-01

    Full Text Available The reproducibility of plasma protein quantitation between laboratories and between instrument types was examined in a large-scale international study involving 16 laboratories and 19 LC–MS/MS platforms, using two kits designed to evaluate instrument performance and one kit designed to evaluate the entire bottom-up workflow. There was little effect of instrument type on the quality of the results, demonstrating the robustness of LC/MRM-MS with isotopically labeled standards. Technician skill was a factor, as errors in sample preparation and sub-optimal LC–MS performance were evident. This highlights the importance of proper training and routine quality control before quantitation is done on patient samples.

  14. The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

    Science.gov (United States)

    Attene-Ramos, Matias S; Miller, Nicole; Huang, Ruili; Michael, Sam; Itkin, Misha; Kavlock, Robert J; Austin, Christopher P; Shinn, Paul; Simeonov, Anton; Tice, Raymond R; Xia, Menghang

    2013-08-01

    Since its establishment in 2008, the US Tox21 inter-agency collaboration has made great progress in developing and evaluating cellular models for the evaluation of environmental chemicals as a proof of principle. Currently, the program has entered its production phase (Tox21 Phase II) focusing initially on the areas of modulation of nuclear receptors and stress response pathways. During Tox21 Phase II, the set of chemicals to be tested has been expanded to nearly 10,000 (10K) compounds and a fully automated screening platform has been implemented. The Tox21 robotic system combined with informatics efforts is capable of screening and profiling the collection of 10K environmental chemicals in triplicate in a week. In this article, we describe the Tox21 screening process, compound library preparation, data processing, and robotic system validation.

  15. A Phrygian Cap

    Directory of Open Access Journals (Sweden)

    Marie-Janne S. van Kamp

    2013-08-01

    Full Text Available A Phrygian cap is a congenital anomaly of the gallbladder with an incidence of 4%. It can simulate a mass in the liver during hepatobiliary imaging and is sometimes mistaken for pathology. A Phrygian cap, however, has no pathological significance and normally causes no symptoms. A case will be presented where a Phrygian cap was found by coincidence during surgery. The patient was operated for colon cancer with liver metastasis in segment V. He underwent a simultaneous right hemicolectomy and wedge resection of the liver lesion. During perioperative inspection, a gallbladder with a folded fundus was seen. This deformity was, in retrospective, detected on the preoperative MRI scan. The patient underwent cholecystectomy to make the wedge resection easier to perform. Otherwise, cholecystectomy for a Phrygian cap is only indicated in case of symptoms. Radiographic imaging can be helpful in narrowing the differential diagnosis. To our knowledge, there is no recent literature about the Phrygian cap and its imaging aspects. Nowadays, multiphase MRI, or multiphase CT in case of MRI contraindication, are the first choices of hepatobiliary imaging.

  16. The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps

    Directory of Open Access Journals (Sweden)

    Ryffel Gerhart U

    2011-01-01

    Full Text Available Abstract Background The three distinct types of kidneys, pronephros, mesonephros and metanephros, develop consecutively in vertebrates. The earliest form of embryonic kidney, the pronephros, is derived from intermediate mesoderm and the first expressed genes localized in the pronephros anlage are the transcription factors osr1, osr2, hnf1b, lhx1 and pax8, here referred to as the early nephrogenic transcription factors. However, the pathway inducing nephrogenesis and the network of theses factors are poorly understood. Treatment of the undifferentiated animal pole explant (animal cap of Xenopus with activin A and retinoic acid induces pronephros formation providing a powerful tool to analyze key molecular events in nephrogenesis. Results We have investigated the expression kinetics of the early nephrogenic transcription factors in activin A and retinoic acid treated animal caps and their potential to induce pronephric differentiation. In treated animal caps, expression of osr1, osr2, hnf1b and lhx1 are induced early, whereas pax8 expression occurs later implying an indirect activation. Activin A alone is able to induce osr2 and lhx1 after three hours treatment in animal caps while retinoic acid fails to induce any of these nephrogenic transcription factors. The early expression of the five transcription factors and their interference with pronephros development when overexpressed in embryos suggest that these factors potentially induce nephrogenesis upon expression in animal caps. But no pronephros development is achieved by either overexpression of OSR1, by HNF1B injection with activin A treatment, or the combined application of LHX1 and PAX8, although they influenced the expression of several early nephrogenic transcription factors in some cases. In an additional approach we could show that HNF1B induces several genes important in nephrogenesis and regulates lhx1 expression by an HNF1 binding site in the lhx1 promoter. Conclusions The early

  17. A novel testing platform for assessing knee joint mechanics: a parallel robotic system combined with an instrumented spatial linkage.

    Science.gov (United States)

    Atarod, Mohammad; Rosvold, Joshua M; Frank, Cyril B; Shrive, Nigel G

    2014-05-01

    Assessing joint function following trauma and its inter-relation with degenerative changes requires an understanding of the normal state of structural loading in the joint. Very few studies have attempted to reproduce joint specific in vivo motions in vitro to quantify the actual loads carried by different tissues within the knee joint. The most significant challenge in this area is the very high sensitivity of the loads in joint structures to motion reproduction accuracy. A novel testing platform for assessing knee joint mechanics is described, comprised of a highly accurate (0.3 ± 0.1 mm, 0.3 ± 0.1°) six-degree-of-freedom (6-DOF) instrumented spatial linkage (ISL) for in vivo joint kinematic assessments and a unique 6-DOF parallel robotic manipulator. A position feedback system (ISL and position controller) is used for accurate reproduction of in vivo joint motions and estimation of "in situ" joint/tissue loads. The parallel robotic manipulator provides excellent stiffness and repeatability in reproducing physiological motions in 6-DOF, compared to the commonly used serial robots. The position feedback system provides real-time feedback data to the robot to reproduce in vivo motions and significantly enhances motion reproduction accuracy by adjusting for robot end-effector movements. Using this combined robot-ISL system, in vivo motions can be reproduced in vitro with very high accuracy (0.1 mm, 0.1°). Our results indicate that this level of accuracy is essential for meaningful estimation of tissue loads during gait. Using this novel testing platform, we have determined the normal load-carrying characteristics of different tissues within the ovine knee joint. The application of this testing system will continue to increase our understanding of normal and pathological joint states. PMID:24519725

  18. GlobAllomeTree: international platform for tree allometric equations to support volume, biomass and carbon assessment

    Directory of Open Access Journals (Sweden)

    Henry M

    2013-07-01

    Full Text Available GlobAllomeTree is an international platform for tree allometric equations. It is the first worldwide web platform designed to facilitate the access of the tree allometric equation and to facilitate the assessment of the tree biometric characteristics for commercial volume, bio-energy or carbon cycling. The webplatform presents a database containing tree allometric equations, a software called Fantallomatrik, to facilitate the comparison and selection of the equations, and documentation to facilitate the development of new tree allometric models, improve the evaluation of tree and forest resources and improve knowledge on tree allometric equations. In the Fantallometrik software, equations can be selected by country, ecological zones, input parameters, tree species, statistic parameters and outputs. The continuously updated database currently contains over 5000 tree allometric equations classified according to 73 fields. The software Fantallometrik can be also used to compare equations, insert new data and estimate the selected output variables using field inventory. The GlobAllomeTree products are freely available at the URL: http://globallometree.org for a range of users including foresters, project developers, scientist, student and government staff.

  19. Fish survey, fishing duration, shellfish resource assessment, and other data from the COMMANDO and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 21 May 1976 to 16 September 1976 (NODC Accession 7700432)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish survey, fishing duration, shellfish resource assessment, and other data were collected from the COMMANDO and other platforms from 21 May 1976 to 16 September...

  20. Adsorption kinetics of pesticide in soil assessed by optofluidics-based biosensing platform.

    Science.gov (United States)

    Long, Feng; Zhu, Anna; Shi, Hanchang; Sheng, Jianwu; Zhao, Zhen

    2015-02-01

    The adsorption of pesticides in soil is a key process that affects transport, degradation, mobility, and bioaccumulation of these substances. To obtain extensive knowledge regarding the adsorption processes of pesticides in the environment, the new green assay technologies for the rapid, sensitive, field-deployable, and accurate quantification of pesticides are required. In the present study, an evanescent wave-based optofluidics biosensing platform (EWOB) was developed by combining advanced photonics and microfluidics technology for the rapid sensitive immunodetection and adsorption kinetics assay of pesticides. The robustness, reusability, and accuracy of the EWOB allow an enhanced prediction of pesticide adsorption kinetics in soil. Using atrazine (ATZ) as the target model, we found that the adsorption kinetics in soil followed a pseudo-second-order kinetic model. EWOB was compared with liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method and yielded a good correlation coefficient (r(2)=0.9968). The underestimated results of LC-MS/MS resulted in a higher adsorption constant of ATZ in soil derived from LC-MS/MS than that of a biosensor. The proposed EWOB system provides a simple, green, and powerful tool to investigate the transport mechanism and fate of pesticide residues.

  1. Effects of subchronic exposures to concentrated ambient particles in mice. IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs.

    Science.gov (United States)

    Lippmann, Morton; Gordon, Terry; Chen, Lung Chi

    2005-04-01

    In order to examine the biologic plausibility of adverse chronic cardiopulmonary effects in humans associated with ambient particulate matter (PM) exposure, we exposed groups of normal mice (C57) and knockout mice that develop atherosclerotic plaque (ApoE-/- and ApoE-/- LDLr-/-) for 6 h/day, 5 days/wk for 5 or 6 mo during the spring/summer of 2003 to either filtered air or 10-fold concentrated ambient particles (CAPs) in Tuxedo, NY (average PM2.5 concentration during exposure = 110 microg/m3). Some of the mice had implanted electrocardiographic monitors. We demonstrated that: (1) this complex interdisciplinary study was technically feasible in terms of daily exposure, collection of air quality monitoring data, the collection, analysis, and interpretation of continuous data on cardiac function, and the collection and analyses of tissues of the animals sacrificed at the end of the study; (2) the daily variations in CAPs were significantly associated, in ApoE-/- mice, with daily variations in cardiac functions; (3) there were significant differences between CAPs and sham-exposed ApoE-/- mice in terms of cardiac function after the end of exposure period, as well as small differences in atherosclerotic plaque density, coronary artery disease, and cell density in the substantia nigra in the brain in the ApoE-/- mice; (4) there are suggestive indications of gene expression changes for genes associated with the control of circadian rhythm in the ApoE-/- LDLr-/- double knockout (DK) mice. These various CAPs-related effects on cardiac function and the development of histological evidence of increased risk of clinically significant disease at the end of exposures in animal models of atherosclerosis provide biological plausibility for the premature mortality associated with PM2.5 exposure in human subjects and provide suggestive evidence for neurogenic disease as well.

  2. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis

    2003-05-01

    The present report summarizes the accomplishments of the project during its second three-month period (from January 2003 through March 2003). The project was initiated with delay in February 2003 due to contractual issues that emerged between the NGA and Foster-Miller, Inc. The two organizations are working diligently to maintain the program's pace so that it is completed in time. The efforts of the project focused during this period in the assessment of the tether technology that is intended to be used as the means of communication between robot and operator. Preliminary results indicate that tether is a viable option under certain pipeline operating conditions but not all. The exact range of operating conditions that are viable for tether use are being determined as the study progresses. Work was also initiated regarding the design of the robotic platform.

  3. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yafei [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Brott, David [Patient Safety, AstraZeneca R and D Wilmington, DE 19850 (United States); Luo, Wenli [Discovery Statistics, AstraZeneca R and D Waltham, MA 02451 (United States); Gangl, Eric [DMPK, AstraZeneca R and D Waltham, MA 02451 (United States); Kamendi, Harriet; Barthlow, Herbert; Lengel, David; Fikes, James; Kinter, Lewis [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Valentin, Jean-Pierre [Global Safety Assessment, AstraZeneca R and D Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Bialecki, Russell, E-mail: russell.bialecki@astrazeneca.com [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States)

    2013-05-01

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development.

  4. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    International Nuclear Information System (INIS)

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development

  5. A human pluripotent stem cell platform for assessing developmental neural toxicity screening

    OpenAIRE

    Hou, Zhonggang; Zhang, Jue; Schwartz, Michael P.; Stewart, Ron; Page, C David; Murphy, William L.; Thomson, James A

    2013-01-01

    A lack of affordable and effective testing and screening procedures mean surprisingly little is known about the health hazards of many of the tens of thousands of chemicals in use in the world today. The recent rise in the number of children affected by neurological disorders such as autism has stirred valuable debate about the role chemicals play in our daily life, highlighting the need for improved methods of assessing chemicals for developmental neural toxicity. Current methods of testing ...

  6. Positional Quality Assessment of Orthophotos Obtained from Sensors Onboard Multi-Rotor UAV Platforms

    Science.gov (United States)

    Mesas-Carrascosa, Francisco Javier; Rumbao, Inmaculada Clavero; Berrocal, Juan Alberto Barrera; Porras, Alfonso García-Ferrer

    2014-01-01

    In this study we explored the positional quality of orthophotos obtained by an unmanned aerial vehicle (UAV). A multi-rotor UAV was used to obtain images using a vertically mounted digital camera. The flight was processed taking into account the photogrammetry workflow: perform the aerial triangulation, generate a digital surface model, orthorectify individual images and finally obtain a mosaic image or final orthophoto. The UAV orthophotos were assessed with various spatial quality tests used by national mapping agencies (NMAs). Results showed that the orthophotos satisfactorily passed the spatial quality tests and are therefore a useful tool for NMAs in their production flowchart. PMID:25587877

  7. Positional quality assessment of orthophotos obtained from sensors onboard multi-rotor UAV platforms.

    Science.gov (United States)

    Mesas-Carrascosa, Francisco Javier; Rumbao, Inmaculada Clavero; Berrocal, Juan Alberto Barrera; Porras, Alfonso García-Ferrer

    2014-11-26

    In this study we explored the positional quality of orthophotos obtained by an unmanned aerial vehicle (UAV). A multi-rotor UAV was used to obtain images using a vertically mounted digital camera. The flight was processed taking into account the photogrammetry workflow: perform the aerial triangulation, generate a digital surface model, orthorectify individual images and finally obtain a mosaic image or final orthophoto. The UAV orthophotos were assessed with various spatial quality tests used by national mapping agencies (NMAs). Results showed that the orthophotos satisfactorily passed the spatial quality tests and are therefore a useful tool for NMAs in their production flowchart.

  8. StudTest – A Platform Supporting Complex and Interactive Knowledge Assessment

    Directory of Open Access Journals (Sweden)

    Vlado Glavinić

    2008-12-01

    Full Text Available This paper describes the model and prototype implementation of a knowledge assessment framework based on problem management components. In order to support student testing with complex problem types and enable usage of rich graphical user interfaces for solution entry, we have developed an e-examination model in which the core concept is a component that can generate complex questions and evaluate students' solutions with additional explanation generation, which we named prlet. The respective system implementation is described, which can operate under heavy loads.

  9. Positional Quality Assessment of Orthophotos Obtained from Sensors Onboard Multi-Rotor UAV Platforms

    Directory of Open Access Journals (Sweden)

    Francisco Javier Mesas-Carrascosa

    2014-11-01

    Full Text Available In this study we explored the positional quality of orthophotos obtained by an unmanned aerial vehicle (UAV. A multi-rotor UAV was used to obtain images using a vertically mounted digital camera. The flight was processed taking into account the photogrammetry workflow: perform the aerial triangulation, generate a digital surface model, orthorectify individual images and finally obtain a mosaic image or final orthophoto. The UAV orthophotos were assessed with various spatial quality tests used by national mapping agencies (NMAs. Results showed that the orthophotos satisfactorily passed the spatial quality tests and are therefore a useful tool for NMAs in their production flowchart.

  10. Positional quality assessment of orthophotos obtained from sensors onboard multi-rotor UAV platforms.

    Science.gov (United States)

    Mesas-Carrascosa, Francisco Javier; Rumbao, Inmaculada Clavero; Berrocal, Juan Alberto Barrera; Porras, Alfonso García-Ferrer

    2014-01-01

    In this study we explored the positional quality of orthophotos obtained by an unmanned aerial vehicle (UAV). A multi-rotor UAV was used to obtain images using a vertically mounted digital camera. The flight was processed taking into account the photogrammetry workflow: perform the aerial triangulation, generate a digital surface model, orthorectify individual images and finally obtain a mosaic image or final orthophoto. The UAV orthophotos were assessed with various spatial quality tests used by national mapping agencies (NMAs). Results showed that the orthophotos satisfactorily passed the spatial quality tests and are therefore a useful tool for NMAs in their production flowchart. PMID:25587877

  11. Implications for platform re-assessment based on in-service damage resulting from accidental loadings

    Energy Technology Data Exchange (ETDEWEB)

    Sharp, J.V.; Stacey, A. [Health and Safety Executive, London (United Kingdom); Frieze, P.A.; Nichols, N.W.

    1996-12-01

    Current offshore design codes enable the capacity of structural components to be determined, but the equations apply only to the undamaged state. The ability to assess the performance of such components containing damage has only recently been developed and is important in the re-assessment of structures. In particular knowledge of the performance of members which are dented or bowed as a result of accidental damage is important in establishing the capacity of structures in-service, when for example using pushover analyses. Much research has been taken on the capacity of dented and bowed members. This paper reviews this data and establishes a database using screening criteria. This data is then compared with theoretical predictions from recently developed draft ISO equations. These show that dents and bows can significantly reduce the performance of members. A survey of offshore damage resulting in repairs has shown that 30% of this damage is the result of accidental events such as ship impact and dropped objects. Most damage found to members was in the form of dents, bows and cracks, with member severance in a few cases. The implications of this information for reassessment and offshore inspections are considered.

  12. Quality Assessment of Roof Planes Extracted from Height Data for Solar Energy Systems by the EAGLE Platform

    Directory of Open Access Journals (Sweden)

    Simon Schuffert

    2015-12-01

    Full Text Available Due to the increasing scarcity of fossil fuels and the upwards trend in energy costs over time, many countries—especially in Europe—have begun to modify their energy policies aiming to increase that percentage obtained from renewable energies. The EAGLE (FP7 program, European Commission has developed a web-based platform to promote renewable energy systems (RES in the public and private sectors, and to deliver a comprehensive information source for all interested users. In this paper, a comprehensive quality assessment of extracted roof planes suitable for solar energy installations (photovoltaic, solar thermal from height data derived automatically from both LiDAR (Light Detection and Ranging and aerial images will be presented. A shadow analysis is performed regarding the daily path of the sun including the shading effects of nearby objects (chimneys, dormers, vegetation, buildings, topography, etc.. A quality assessment was carried out for both LiDAR and aerial images of the same test sites in UK and Germany concerning building outline accuracy, extraction rate of roof planes and the accuracy of their geometric parameters (inclination and aspect angle, size. The benefit is an optimized system to extract roof planes for RES with a high level of detail, accuracy and flexibility (concerning different commonly available data sources including an estimation of quality of the results which is important for individual house owners as well as for regional applications by governments or solar energy companies to judge their usefulness.

  13. A Delay Vector Variance based Marker for an Output-Only Assessment of Structural Changes in Tension Leg Platforms

    Science.gov (United States)

    Jaksic, V.; Wright, C.; Mandic, D. P.; Murphy, J.; Pakrashi, V.

    2015-07-01

    Although aspects of power generation of many offshore renewable devices are well understood, their dynamic responses under high wind and wave conditions are still to be investigated to a great detail. Output only statistical markers are important for these offshore devices, since access to the device is limited and information about the exposure conditions and the true behaviour of the devices are generally partial, limited, and vague or even absent. The markers can summarise and characterise the behaviour of these devices from their dynamic response available as time series data. The behaviour may be linear or nonlinear and consequently a marker that can track the changes in structural situations can be quite important. These markers can then be helpful in assessing the current condition of the structure and can indicate possible intervention, monitoring or assessment. This paper considers a Delay Vector Variance based marker for changes in a tension leg platform tested in an ocean wave basin for structural changes brought about by single column dampers. The approach is based on dynamic outputs of the device alone and is based on the estimation of the nonlinearity of the output signal. The advantages of the selected marker and its response with changing structural properties are discussed. The marker is observed to be important for monitoring the as- deployed structural condition and is sensitive to changes in such conditions. Influence of exposure conditions of wave loading is also discussed in this study based only on experimental data.

  14. Mechanical capping of silica nanotubes for encapsulation of molecules.

    Science.gov (United States)

    Yu, Jaeeun; Bai, Xia; Suh, Junghun; Lee, Sang Bok; Son, Sang Jun

    2009-11-01

    Multifunctional silica nanotubes (SNTs) are being widely used for many biomedical applications due to their structural benefits. Controlling the structure of the open end of an SNT is a crucial step for drug/gene delivery and for fabrication of multifunctional SNTs. We developed a mechanical capsulation method to fabricate caps at the ends of SNTs. A thin layer of malleable capping materials (Au, Ag, PLGA) was deposited onto the surface of an SNT-grown AAO template. Capped SNTs were then obtained by hammering with alumina microbeads. For a proof-of-concept experiment, we demonstrated dye-encapsulated SNTs without any chemical functionalizations. Since a mechanical approach is free of the issue of chemical compatibility between cargo molecules and capping materials, the method can provide an effective platform for the preparation of smart multifunctional nanotubes for biomedical applications. PMID:19824675

  15. Performance of blasting caps

    Science.gov (United States)

    Bement, Laurence J. (Inventor); Schimmel, Morry L. (Inventor); Perry, Ronnie B. (Inventor)

    1993-01-01

    Common blasting caps are made from an aluminum shell in the form of a tube which is closed at both ends. One end, which is called the output end, terminates in a principal side or face, and contains a detonating agent which communicates with a means for igniting the detonating agent. The improvement of the present invention is a flat, steel foil bonded to the face in a position which is aligned perpendicularly to the longitudinal axis of the tube.

  16. Capping the Mortgage Interest Deduction

    OpenAIRE

    Anderson, John E.; Clemens, Jeffrey; Hanson, Andrew

    2007-01-01

    In this paper we examine the economic implications of several policy options for capping the mortgage interest deduction (MID). We extend the standard user–cost model of owner–occupied housing to include a cap on the mortgage size receiving tax–favored status. Our user–cost estimates for taxpayers with mortgages above the current–law cap are 4.41 percent higher than estimates from a model without the cap. We simulate the share of mortgage dollars that would be subject to three alternative cap...

  17. An adaptable mesocosm platform for performing integrated assessments of nanomaterial risk in complex environmental systems

    Science.gov (United States)

    Auffan, Mélanie; Tella, Marie; Santaella, Catherine; Brousset, Lenka; Paillès, Christine; Barakat, Mohamed; Espinasse, Benjamin; Artells, Ester; Issartel, Julien; Masion, Armand; Rose, Jérôme; Wiesner, Mark R.; Achouak, Wafa; Thiéry, Alain; Bottero, Jean-Yves

    2014-07-01

    Physical-chemists, (micro)biologists, and ecologists need to conduct meaningful experiments to study the environmental risk of engineered nanomaterials with access to relevant mechanistic data across several spatial and temporal scales. Indoor aquatic mesocosms (60L) that can be tailored to virtually mimic any ecosystem appear as a particularly well-suited device. Here, this concept is illustrated by a pilot study aimed at assessing the distribution of a CeO2-based nanomaterial within our system at low concentration (1.5 mg/L). Physico-chemical as well as microbiological parameters took two weeks to equilibrate. These parameters were found to be reproducible across the 9-mesocosm setup over a 45-day period of time. Recovery mass balances of 115 +/- 18% and 60 +/- 30% of the Ce were obtained for the pulse dosing and the chronic dosing, respectively. This demonstrated the relevance of our experimental approach that allows for adequately monitoring the fate and impact of a given nanomaterial.

  18. Saltstone Clean Cap Formulation

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C

    2005-04-22

    The current operation strategy for using Saltstone Vault 4 to receive 0.2 Ci/gallon salt solution waste involves pouring a clean grout layer over the radioactive grout prior to initiating pour into another cell. This will minimize the radiating surface area and reduce the dose rate at the vault and surrounding area. The Clean Cap will be used to shield about four feet of Saltstone poured into a Z-Area vault cell prior to moving to another cell. The minimum thickness of the Clean Cap layer will be determined by the cesium concentration and resulting dose levels and it is expected to be about one foot thick based on current calculations for 0.1 Ci Saltstone that is produced in the Saltstone process by stabilization of 0.2 Ci salt solution. This report documents experiments performed to identify a formulation for the Clean Cap. Thermal transient calculations, adiabatic temperature rise measurements, pour height, time between pour calculations and shielding calculations were beyond the scope and time limitations of this study. However, data required for shielding calculations (composition and specific gravity) are provided for shielding calculations. The approach used to design a Clean Cap formulation was to produce a slurry from the reference premix (10/45/45 weight percent cement/slag/fly ash) and domestic water that resembled as closely as possible the properties of the Saltstone slurry. In addition, options were investigated that may offer advantages such as less bleed water and less heat generation. The options with less bleed water required addition of dispersants. The options with lower heat contained more fly ash and less slag. A mix containing 10/45/45 weight percent cement/slag/fly ash with a water to premix ratio of 0.60 is recommended for the Clean Cap. Although this mix may generate more than 3 volume percent standing water (bleed water), it has rheological, mixing and flow properties that are similar to previously processed Saltstone. The recommended

  19. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis

    2003-07-01

    This development program is a joint effort among the Northeast Gas Association (formerly New York Gas Group), Foster-Miller, Inc., and the US Department of Energy (DOE) through the National Energy Technology Laboratory (NETL). The DOE's contribution to this project is $572,525 out of a total of $772,525. The present report summarizes the accomplishments of the project during its third three-month period (from April 2003 through June 2003). The project was initiated with delay in February 2003 due to contractual issues that emerged between NGA and Foster-Miller, Inc. The two organizations are working diligently to maintain the program's pace and expect to complete it in time. The efforts of the project focused during this period in finalizing the assessment of the tether technology, which is intended to be used as the means of communication between robot and operator. Results indicate that the tether is a viable option under certain pipeline operating conditions, but not all. Concerns also exist regarding the abrasion resistance of the tether, this issue being the last studied. Substantial work was also conducted on the design of the robotic platform, which has progressed very well. Finally, work on the MFL sensor, able to negotiate all pipeline obstacles (including plug valves), was initiated by PII following the successful completion of the subcontract negotiations between Foster-Miller and PII. The sensor design is at this point the critical path in the project's timetable.

  20. In-situ subaqueous capping of mercury-contaminated sediments in a fresh-water aquatic system, Part I—Bench-scale microcosm study to assess methylmercury production

    Energy Technology Data Exchange (ETDEWEB)

    Randall, Paul M., E-mail: randall.paul@epa.gov [U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 26 W. Martin Luther King Drive, Cincinnati, OH 45268 (United States); Fimmen, Ryan [Geosyntec Consultants, 150 E. Wilson Bridge Road, Suite 232, Worthington, OH 43085 (United States); Lal, Vivek; Darlington, Ramona [Battelle, 505 King Ave., Columbus, OH 43201 (United States)

    2013-08-15

    Bench-scale microcosm experiments were designed to provide a better understanding of the potential for Hg methylation in sediments from an aquatic environment. Experiments were conducted to examine the function of sulfate concentration, lactate concentration, the presence/absence of an aqueous inorganic Hg spike, and the presence/absence of inoculums of Desulfovibrio desulfuricans, a strain of sulfate-reducing bacteria (SRB) commonly found in the natural sediments of aquatic environments. Incubations were analyzed for both the rate and extent of (methylmercury) MeHg production. Methylation rates were estimated by analyzing MeHg and Hg after 2, 7, 14, 28, and 42 days. The production of metabolic byproducts, including dissolved gases as a proxy for metabolic utilization of carbon substrate, was also monitored. In all treatments amended with lactate, sulfate, Hg, and SRB, MeHg was produced (37 ng/g-sediment dry weight) after only 48 h of incubation and reached a maximum sediment concentration of 127 ng/g-sediment dry weight after the 42 day incubation period. Aqueous phase production of MeHg was observed to be 10 ng/L after 2 day, reaching a maximum observed concentration of 32.8 ng/L after 14 days, and declining to 10.8 ng/L at the end of the incubation period (42 day). The results of this study further demonstrates that, in the presence of an organic carbon substrate, sulfate, and the appropriate consortia of microorganisms, sedimentary Hg will be transformed into MeHg through bacterial metabolism. Further, this study provided the basis for evaluation of an in-situ subaqueous capping strategy that may limit (or potentially enhance) MeHg production. -- Highlights: • Hg methylation by SRB is limited by the depletion of sulfate and carbon. • Hg methylation is sensitive to competition by methanogens for carbon substrate. • In high lactate environment, all lactate was utilized in the microcosms within seven days. • In the absence of adequate metabolic fuel, Me

  1. Impact Response Study on Covering Cap of Aircraft Big-Size Integral Fuel Tank

    Science.gov (United States)

    Wang, Fusheng; Jia, Senqing; Wang, Yi; Yue, Zhufeng

    2016-10-01

    In order to assess various design concepts and choose a kind of covering cap design scheme which can meet the requirements of airworthiness standard and ensure the safety of fuel tank. Using finite element software ANSYS/LS- DYNA, the impact process of covering cap of aircraft fuel tank by projectile were simulated, in which dynamical characteristics of simple single covering cap and gland double-layer covering cap impacted by titanium alloy projectile and rubber projectile were studied, as well as factor effects on simple single covering cap and gland double-layer covering cap under impact region, impact angle and impact energy were also studied. Though the comparison of critical damage velocity and element deleted number of the covering caps, it shows that the external covering cap has a good protection effect on internal covering cap. The regions close to boundary are vulnerable to appear impact damage with titanium alloy projectile while the regions close to center is vulnerable to occur damage with rubber projectile. Equivalent strain in covering cap is very little when impact angle is less than 15°. Element deleted number in covering cap reaches the maximum when impact angle is between 60°and 65°by titanium alloy projectile. While the bigger the impact angle and the more serious damage of the covering cap will be when rubber projectile impact composite covering cap. The energy needed for occurring damage on external covering cap and internal covering cap is less than and higher than that when single covering cap occur damage, respectively. The energy needed for complete breakdown of double-layer covering cap is much higher than that of single covering cap.

  2. A combined approach to assessing the conservation status of Cap des Trois Fourches as a potential MPA: is there a shortage of MPAs in the southern Mediterranean?

    Directory of Open Access Journals (Sweden)

    F. ESPINOSA

    2014-09-01

    Full Text Available The Mediterranean basin is recognized as one of the most diverse regions on the planet, but is being threatened by overexploitation and habitat loss. Furthermore, the Strait of Gibraltar and adjacent Alboran Sea have been identified as representing an important habitat for many threatened or endangered species. In this context, one vehicle for marine conservation is the creation of marine protected sites, although Mediterranean Marine Protected Areas (MPAs are neither large nor representative enough to form an effective network of protection. An inventory of the benthic communities and habitats of conservation interest has been carried out in Cap des Trois Fourches, an ecological and biogeographical site of interest. Univariate and multivariate analyses showed differences for marine communities among habitats and localities, indicating a great diversity in marine assemblages but an absence of a spatial gradient in marine α-diversity. The Trois Fourches area showed a high environmental quality and hosted several endangered species. Habitats of conservation concern, such as marine caves, seagrass meadows and coralligenous assemblages, were detected and studied. The scientific data recorded provide sound support for the establishment of a new MPA in Trois Fourches, taking into account that the findings match the scientific criteria required for declaration as a protected area. The benefits for connectivity at the Mediterranean scale and the local economy are discussed.

  3. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OR SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis

    2004-02-01

    This development program is a joint effort among the Northeast Gas Association (formerly New York Gas Group), Foster-Miller, Inc., GE Oil & Gas (PII), and the US Department of Energy (DOE) through the National Energy Technology Laboratory (NETL). The total cost of the project is $772,525, with the National Energy Technology Laboratory of the US Department of Energy contributing $572,525, and the Northeast Gas Association contributing $200,000. The present report summarizes the accomplishments of the project during its fifth three-month period (from October 2003 through December 2003). The efforts of the project focused during this period in completing the assessment of the tether technology, which is intended to be used as the means of communication between robot and operator, in completing the design of the MFL sensor modules, and in completing the kinematic studies and tractor design. In addition, work on the ovality sensor has been completed, while work on system integration is nearly complete. Results to date indicate that the robotic system under design will be able to meet most of the design specifications initially prescribed. The kinematic analysis shows that from a locomotor point of view an inspection of a 16 inch-24 inch pipe size range with a single platform is most likely possible. However, the limitations imposed by the sensor are more restrictive, final preliminary design results showing that in order to cover this pipe range, two different sensor systems will be needed; one for the 16 inch-20 inch pipe size range and one for the 20 inch-24 inch range. Finally, the analysis has shown that tether operation will be limited to flows of less than 30 ft/sec; these results will have to be confirmed experimentally during the next phase of work.

  4. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis; Bill Leary

    2004-01-14

    This development program is a joint effort among the Northeast Gas Association (formerly New York Gas Group), Foster-Miller, Inc., and the US Department of Energy (DOE) through the National Energy Technology Laboratory (NETL). The total cost of the project is $772,525, with the National Energy Technology Laboratory of the US Department of Energy contributing $572,525, and the Northeast Gas Association contributing $200,000. The present report summarizes the accomplishments of the project during its fourth three-month period (from July 2003 through September 2003). The efforts of the project focused during this period in completing the assessment of the tether technology, which is intended to be used as the means of communication between robot and operator, in designing the MFL sensor module, in completing the kinematic studies, and in initiating tractor design. In addition, work on the ovality sensor progressed significantly, while work on system integration was initiated focusing at this point in time on module coupling. Results to date indicate that the robotic system under design will be able to meet most of the design specifications initially specified. Earlier concerns regarding the portability of the system are shown to be a non-issue, with new more detailed analysis showing that from a locomotor point of view an inspection of a 16 inch-24 inch pipe size range with a single platform is most likely possible However, the limitations imposed by the sensor are more restrictive, preliminary results indicating an inspection range of 16 inch-20 inch pipe sizes. In addition, tether use will most likely have to be limited to medium and low flow conditions in order to preserve tether integrity.

  5. ATLAS end-cap detector

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Three scientists from the Institute of Nuclear Phyiscs at Novossibirsk with one of the end-caps of the ATLAS detector. The end-caps will be used to detect particles produced in the proton-proton collisions at the heart of the ATLAS experiment that are travelling close to the axis of the two beams.

  6. Platform Constellations

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2016-01-01

    This research paper presents an initial attempt to introduce and explain the emergence of new phenomenon, which we refer to as platform constellations. Functioning as highly modular systems, the platform constellations are collections of highly connected platforms which co-exist in parallel and a......’ acquisition and users’ engagement rates as well as unlock new sources of value creation and diversify revenue streams....

  7. Palmer Quest: A Feasible Nuclear Fission "Vision Mission" to the Mars Polar Caps

    Science.gov (United States)

    Carsey, F. D.; Beegle, L. W.; Nakagawa, R.; Elliott, J. O.; Matthews, J. B.; Coleman, M. L.; Hecht, M. H.; Ivaniov, A. B.; Head, J. W.; Milkovich, S.

    2005-01-01

    We are engaged in a NASA Vision Mission study, called Palmer Quest after the American Antarctic explorer Nathaniel Palmer, to assess the presence of life and evaluate the habitability of the basal domain of the Mars polar caps. We address this goal through four objectives: 1. Determine the presence of amino acids, nutrients, and geochemical heterogeneity in the ice sheet. 2. Quantify and characterize the provenance of the amino acids in Mars ice. 3. Assess the stratification of outcropped units for indications of habitable zones. 4. Determine the accumulation of ice, mineralogic material, and amino acids in Mars ice caps over the present epoch. Because of the defined scientific goal for the vision mission, the Palmer Quest focus is astrobiological; however, the results of the study make us optimistic that aggressive multi-platform in-situ missions that address a wide range of objectives, such as climate change, can be supported by variations of the approach used on this mission. Mission Overview: The Palmer Quest baseline

  8. Lysimeter Platform

    Science.gov (United States)

    Klammler, Gernot; Murer, Erwin; Plieschnegger, Markus

    2014-05-01

    The existing European Lysimeter Platform (www.lysimeter.at/HP_EuLP) provides an overview of lysimeter types used in Europe and show details on equipment, research results and future perspectives of lysimeter facilities. However, this platform is not user-editable and has not been updated since 2008. Thus, the Lysimeter Research Group (www.lysimeter.at) intends to serve a new database based website called Lysimeter Platform, where existing information of the former European Lysimeter Platform will be transferred to the new Lysimeter Platform and, furthermore, registered users are able to create and edit sites where lysimeters, soil water samplers and soil hydrologic measuring profiles are operated. The Lysimeter Research Group is a scientific association and, therefore, the membership is free of charge. The new Lysimeter Platform contains general information of lysimeter sites worldwide (e.g., what is measured at which site) in a standardized form to get a quick but informative overview of the sites and can be linked to more detailed, already existing information provided by the site operators. Due to the standardized information in the database the Lysimeter Platform serves also as search-engine for soil water measurements and helps to find sites of interest and corresponding contact information worldwide. The Session "Estimation of soil-atmosphere and vadose zone water fluxes by use of precision lysimeter measurements" at the EGU General Assembly 2014 would be an excellent chance to present the idea and the concept of this new Lysimeter Platform to international site operators and scientists.

  9. The inter-rater reliability of categories of auditory performance-II (CAP)-II

    OpenAIRE

    Gilmour, Louise

    2010-01-01

    The aim of the present study was to validate a modified version of the Categories of Auditory Performance (CAP) rating scale, the CAP-II. The CAP is a hierarchy rating scale which assesses a child?s functioning in everyday situations. It covers a range of auditory performance and also takes into consideration different developmental rates of children. Inter-rater reliability was assessed by participants rating benefits young children receive with cochlear implants (CI). Volunteers watched vid...

  10. ATLAS - End-Cap calorimeter

    CERN Multimedia

    2006-01-01

    The End-cap calorimeter was moved with the help of the rails and this calorimeter will measure the energy of particles close to the beam axis when protons collide. Cooling is important for maximum detector efficiency.

  11. Researchers dodge UK migration cap

    Science.gov (United States)

    Dacey, James

    2011-03-01

    Research scientists are among those to be prioritized under the UK government's new immigration rules that will impose an annual cap on the number of work visas issued to those from outside the European Union (EU).

  12. Genetics Home Reference: cap myopathy

    Science.gov (United States)

    ... or a spine that curves to the side ( scoliosis ). The name cap myopathy comes from characteristic abnormal ... health conditions: Diagnostic Tests Drug Therapy Surgery and Rehabilitation Genetic Counseling Palliative Care Related Information How are ...

  13. Assessing conservation agricultural production systems (CAPS) for small holder farmers in rain-fed farming system in sub-Saharan Africa (SSA)

    OpenAIRE

    Nambozo, J.; Norton, Jay B.; Okeyo, M.; Judith A Odhiambo; Owori, M.; Oluko, P.; Ogonga, P.

    2012-01-01

    The challenge of sufficient food production by farmers in rainfed farming systems of sub-Saharan Africa is exacerbated by soil degradation and poor soil nutrient status. The objective of this study was to assess the effects of reduced and no tillage and velvet bean (Mucuna pruriens) cover crop on greenhouse gas (GHG) emissions and noxious weed population in alternative cropping practices to maize-bean production. Using a completely randomized block design, four replications of three tillage i...

  14. Platform Performance and Challenges - using Platforms in Lego Company

    DEFF Research Database (Denmark)

    Munk, Lone; Mortensen, Niels Henrik

    2009-01-01

    This article studies the performance and challenges of using nine implemented product platforms in LEGO Company. Most of these do produce results, but do not meet their goals due to challenges in their usage in the daily product. The main challenges are that the platforms are not being used...... needs focus on the incentive of using the platform. This problem lacks attention in literature, as well as industry, where assessment criteria do not cover this aspect. Therefore, we recommend including user incentive in platform assessment criteria to these challenges. Concrete solution elements...

  15. Downlink Coexistence Performance Assessment and Techniques for WiMAX Services from High Altitude Platform and Terrestrial Deployments

    OpenAIRE

    Grace D; Yang Z.; Mohammed A; Hult T

    2008-01-01

    Abstract We investigate the performance and coexistence techniques for worldwide interoperability for microwave access (WiMAX) delivered from high altitude platforms (HAPs) and terrestrial systems in shared 3.5 GHz frequency bands. The paper shows that it is possible to provide WiMAX services from individual HAP systems. The coexistence performance is evaluated by appropriate choice of parameters, which include the HAP deployment spacing radius, directive antenna beamwidths based on ado...

  16. A Multichannel Bioluminescence Determination Platform for Bioassays.

    Science.gov (United States)

    Kim, Sung-Bae; Naganawa, Ryuichi

    2016-01-01

    The present protocol introduces a multichannel bioluminescence determination platform allowing a high sample throughput determination of weak bioluminescence with reduced standard deviations. The platform is designed to carry a multichannel conveyer, an optical filter, and a mirror cap. The platform enables us to near-simultaneously determine ligands in multiple samples without the replacement of the sample tubes. Furthermore, the optical filters beneath the multichannel conveyer are designed to easily discriminate colors during assays. This optical system provides excellent time- and labor-efficiency to users during bioassays.

  17. A Multichannel Bioluminescence Determination Platform for Bioassays.

    Science.gov (United States)

    Kim, Sung-Bae; Naganawa, Ryuichi

    2016-01-01

    The present protocol introduces a multichannel bioluminescence determination platform allowing a high sample throughput determination of weak bioluminescence with reduced standard deviations. The platform is designed to carry a multichannel conveyer, an optical filter, and a mirror cap. The platform enables us to near-simultaneously determine ligands in multiple samples without the replacement of the sample tubes. Furthermore, the optical filters beneath the multichannel conveyer are designed to easily discriminate colors during assays. This optical system provides excellent time- and labor-efficiency to users during bioassays. PMID:27424912

  18. Platform contents

    OpenAIRE

    Renault, Régis

    2014-01-01

    A monopoly platform hosts advertisers who compete on a market for horizontally differentiated products. These products may be either mass market products that appeal broadly to the entire consumer population or niche products that are tailored to the tastes of some particular group. Consumers search sequentially through ads incurring a surfing cost of moving to the next ad. They may click on an ad at some cost, which provides all relevant information and the opportunity to buy. The platform c...

  19. Cr isotope stratigraphy of Ediacaran cap dolostones, Doushantuo Formation, South China

    Science.gov (United States)

    Rodler, Alexandra; Hohl, Simon V.; Guo, Qingjun; Frei, Robert

    2016-04-01

    The Yangtze Platform in South China is considered a key site for studying Neoproterozoic ocean oxygenation. The chromium isotope composition (δ53Cr) of marine carbonates has shown to be a sensitive tracer of changing (paleo)redox conditions and was previously linked to photosynthetic activity (1). We applied this emerging proxy to cap dolostones of a deep water and a shallow marine carbonate section pertaining to the Doushantuo Formation that have previously been used to constrain the redox evolution of Ediacaran seawater (2,3). Postglacial detrital contamination and diagenetic alteration appear to have influenced the δ53Cr values of Doushantuo cap dolostones as evidenced by systematic changes in δ53Cr and Cr concentrations coupled with several geochemical tracers. We use Al concentrations as indicator of detrital contamination and to calculate the authigenic Cr isotope composition. Further, we hypothesis that post-depositional remobilization of Cr might have resulted in the loss of heavy Cr isotopes and the retention of light Cr isotopes during precipitation of secondary carbonates. This scenario is supported by a decrease in δ53Cr values that is correlated with a loss of Sr and increasingly light δ18Ocarb signals, which would indicate meteoric fluid/rock interaction and diagenetic alteration by continental basin fluids. However, some cap dolostones may still show pristine Ediacaran seawater signals with positively fractionated δ53Cr (relative to bulk silicate Earth; 4), 87Sr/86Sr close to Ediacaran seawater values and a pronounced negative Ce anomaly. These tracers reveal light pulses of enhanced postglacial oxidative weathering during cap dolostone deposition. The Cr isotope composition of Ediacaran cap dolostones pertaining to the Doushantuo Formation trace changes in past redox conditions, where fine-scale δ53Cr fluctuations are perhaps a result of detrital contamination and diagenetic alteration balanced against a signal of oxidative weathering

  20. Review of Dublin Institute of Technology's E-Learning Platform for Effective Teaching Fromative Assessment and Feedback

    OpenAIRE

    Kehily, Dermot

    2011-01-01

    This paper investigates Dublin Institute of Technology’s (DIT) ‘webcourses.dit.ie’ created for DIT with Blackboard Learning System software as an effective e-learning tool on a module in the School of Real Estate and Construction Economics in DIT. Webcourses.dit.ie is an e-learning platform providing support and assistance to both lecturers and students as part of their daily teaching and learning experience. Webcourses as it is known in DIT is both a course management system for lecturers an...

  1. Creation of polar cap patches

    Science.gov (United States)

    Hosokawa, K.; Taguchi, S.; Ogawa, Y.

    2014-12-01

    Polar cap patches, which are islands of enhanced plasma density drifting anti-sunward, are one of the outstanding phenomena in the polar cap F region ionosphere. In the last decade, data from all-sky airglow imagers have been extensively used for better understanding the propagation of patches in the central polar cap region. But still, it has been rather difficult to capture the birth of patches in their generation region near the dayside cusp, because, in most places, the dayside part of the polar cap ionosphere is sunlit even in winter. In Longyearbyen (78.1N, 15.5E), Norway, however, optical observations are possible near the dayside cusp region in a limited period around the winter solstice. This enables us to directly image how polar cap patches are born in the cusp. In this paper, we present a few intervals of daytime optical observations, during which polar cap patches were generated within the field-of-view of an all-sky imager in Longyearbyen. During all the intervals studied here, we identified several signatures of poleward moving auroral forms (PMAF) in the equatorward half of the field-of-view, which are known as ionospheric manifestations of dayside reconnection. Interestingly, patches were directly produced from such poleward moving auroral signatures and propagated poleward along the anti-sunward convection near the cusp. In the literature, Lorentzen et al. (2012) first reported such a direct production of patches from PMAFs. During the current observations, however, we succeeded in tracking the propagation of patches until they reached the poleward edge of the field-of-view of the imager. This confirms that the faint airglow structures produced from PMAFs were actually transported for a long distance towards the central polar cap area; thus, polar cap patches were produced. From this set of observations, we suggest that polar cap patches during moderately disturbed conditions (i.e, non-storm time conditions) can be directly produced by the

  2. Biomimicry 3D gastrointestinal spheroid platform for the assessment of toxicity and inflammatory effects of zinc oxide nanoparticles.

    Science.gov (United States)

    Chia, Sing Ling; Tay, Chor Yong; Setyawati, Magdiel I; Leong, David T

    2015-02-11

    Our current mechanistic understanding on the effects of engineered nanoparticles (NPs) on cellular physiology is derived mainly from 2D cell culture studies. However, conventional monolayer cell culture may not accurately model the mass transfer gradient that is expected in 3D tissue physiology and thus may lead to artifactual experimental conclusions. Herein, using a micropatterned agarose hydrogel platform, the effects of ZnO NPs (25 nm) on 3D colon cell spheroids of well-defined sizes are examined. The findings show that cell dimensionality plays a critical role in governing the spatiotemporal cellular outcomes like inflammatory response and cytotoxicity in response to ZnO NPs treatment. More importantly, ZnO NPs can induce different modes of cell death in 2D and 3D cell culture systems. Interestingly, the outer few layers of cells in 3D model could only protect the inner core of cells for a limited time and periodically slough off from the spheroids surface. These findings suggest that toxicological conclusions made from 2D cell models might overestimate the toxicity of ZnO NPs. This 3D cell spheroid model can serve as a reproducible platform to better reflect the actual cell response to NPs and to study a more realistic mechanism of nanoparticle-induced toxicity. PMID:25331163

  3. The North Zealand CAP Monitor

    DEFF Research Database (Denmark)

    Nielsen, Minna; Ravn, Pernille; Notander Clausen, Lise;

    2016-01-01

    nurses and two senior doctors. Direct observations of the clinical processes revealed problems of coordination, complex disease trajectories that did not fit with the pneumonia pathway, unclear guidelines and variation in their interpretation. Intervention We designed a measurement system to monitor...... patients with CAP and effects of interventions to improve the quality of their care. Based on current literature we defined and tested a set of indicators and designed an audit form, a database and a dashboard for presenting the results. Two nurses monthly audited randomly selected files of patients...... steps of the pneumonia pathway. Lessons learnt Quality of care for CAP was worse than expected. Defining and agreeing upon a set of indicators was difficult and time consuming but useful to improve our understanding of how care for CAP was in routine clinical practice. Several indicators we initially...

  4. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis; William Leary

    2004-03-01

    The National Energy Technology Laboratory of the US Department of Energy (under Award DE-FC26-02NT41645) and the NYSEARCH Committee of the Northeast Gas Association (previous the New York Gas Group), have sponsored research to develop a robotic pipeline inspection system capable of navigation through the typical physical and operational obstacles that make transmission and distribution pipelines unpiggable. The research contractors, Foster-Miller and GE Oil & Gas (PII North America) have performed an engineering study and developed a conceptual design that meets all the requirements for navigating and inspecting unpiggable transmission pipelines. Based on Foster-Miller's previous efforts developing the Pipe Mouse robot, the RoboScan inspection robot (Figure ES-1) meets the navigational and physical challenges of unpiggable pipelines through an innovative modular platform design, segmented MFL inspection modules and improvements to the inter-module coupling design.

  5. Development of CAP code for nuclear power plant containment: Lumped model

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Soon Joon, E-mail: sjhong90@fnctech.com [FNC Tech. Co. Ltd., Heungdeok 1 ro 13, Giheung-gu, Yongin-si, Gyeonggi-do 446-908 (Korea, Republic of); Choo, Yeon Joon; Hwang, Su Hyun; Lee, Byung Chul [FNC Tech. Co. Ltd., Heungdeok 1 ro 13, Giheung-gu, Yongin-si, Gyeonggi-do 446-908 (Korea, Republic of); Ha, Sang Jun [Central Research Institute, Korea Hydro & Nuclear Power Company, Ltd., 70, 1312-gil, Yuseong-daero, Yuseong-gu, Daejeon 305-343 (Korea, Republic of)

    2015-09-15

    Highlights: • State-of-art containment analysis code, CAP, has been developed. • CAP uses 3-field equations, water level oriented upwind scheme, local head model. • CAP has a function of linked calculation with reactor coolant system code. • CAP code assessments showed appropriate prediction capabilities. - Abstract: CAP (nuclear Containment Analysis Package) code has been developed in Korean nuclear society for the analysis of nuclear containment thermal hydraulic behaviors including pressure and temperature trends and hydrogen concentration. Lumped model of CAP code uses 2-phase, 3-field equations for fluid behaviors, and has appropriate constitutive equations, 1-dimensional heat conductor model, component models, trip and control models, and special process models. CAP can run in a standalone mode or a linked mode with a reactor coolant system analysis code. The linked mode enables the more realistic calculation of a containment response and is expected to be applicable to a more complicated advanced plant design calculation. CAP code assessments were carried out by gradual approaches: conceptual problems, fundamental phenomena, component and principal phenomena, experimental validation, and finally comparison with other code calculations on the base of important phenomena identifications. The assessments showed appropriate prediction capabilities of CAP.

  6. Development of CAP code for nuclear power plant containment: Lumped model

    International Nuclear Information System (INIS)

    Highlights: • State-of-art containment analysis code, CAP, has been developed. • CAP uses 3-field equations, water level oriented upwind scheme, local head model. • CAP has a function of linked calculation with reactor coolant system code. • CAP code assessments showed appropriate prediction capabilities. - Abstract: CAP (nuclear Containment Analysis Package) code has been developed in Korean nuclear society for the analysis of nuclear containment thermal hydraulic behaviors including pressure and temperature trends and hydrogen concentration. Lumped model of CAP code uses 2-phase, 3-field equations for fluid behaviors, and has appropriate constitutive equations, 1-dimensional heat conductor model, component models, trip and control models, and special process models. CAP can run in a standalone mode or a linked mode with a reactor coolant system analysis code. The linked mode enables the more realistic calculation of a containment response and is expected to be applicable to a more complicated advanced plant design calculation. CAP code assessments were carried out by gradual approaches: conceptual problems, fundamental phenomena, component and principal phenomena, experimental validation, and finally comparison with other code calculations on the base of important phenomena identifications. The assessments showed appropriate prediction capabilities of CAP

  7. Establishing diagnostic platform for environmental biosafety assessment of genetically modified plants based on the decision-tree method

    OpenAIRE

    Lei Wang; Chao Yang; Bao-Rong Lu

    2010-01-01

    Transgenic biotechnology and its products provide important solutions for the great challenge of global food security. Biosafety assessment of genetically modified organisms (GMOs) including their food and environmental safety is a prerequisite for the commercialization and safe application of transgenic biotechnologyproducts. However, existing methodologies cannot meet the urgent requirements for rapid biosafety assessment of the increasing number of new and sophisticated GMOs. Therefore, a ...

  8. Platform computing

    CERN Multimedia

    2002-01-01

    "Platform Computing releases first grid-enabled workload management solution for IBM eServer Intel and UNIX high performance computing clusters. This Out-of-the-box solution maximizes the performance and capability of applications on IBM HPC clusters" (1/2 page) .

  9. Payment Platform

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Damsgaard, Jan

    2012-01-01

    Payment transactions through the use of physical coins, bank notes or credit cards have for centuries been the standard formats of exchanging money. Recently online and mobile digital payment platforms has entered the stage as contenders to this position and possibly could penetrate societies...

  10. From Blogs to Bottle Caps

    Science.gov (United States)

    Edinger, Ted

    2012-01-01

    There is a wonderful community of art educators connecting a once-isolated profession through blogging. Art educators around the world are sharing ideas and communicating with their peers through this amazing resource. In this article, the author describes the bottle cap mural at Tulip Grove Elementary School which was inspired by this exchange of…

  11. Assessment of the Ionospheric and Tropospheric Effects in Location Errors of Data Collection Platforms in Equatorial Region during High and Low Solar Activity Periods

    Directory of Open Access Journals (Sweden)

    Áurea Aparecida da Silva

    2012-01-01

    Full Text Available The geographical locations of data collection platforms (DCP in the Brazilian Environmental Data Collection System are obtained by processing Doppler shift measurements between satellites and DCP. When the signals travel from a DCP to a satellite crossing the terrestrial atmosphere, they are affected by the atmosphere layers, which generate a delay in the signal propagation, and cause errors in its final location coordinates computation. The signal propagation delay due to the atmospheric effects consists, essentially, of the ionospheric and tropospheric effects. This work provides an assessment of ionospheric effects using IRI and IONEX models and tropospheric delay compensation using climatic data provided by National Climatic Data Center. Two selected DCPs were used in this study in conjunction with SCD-2 satellite during high and low solar activity periods. Results show that the ionospheric effects on transmission delays are significant (about hundreds of meters in equatorial region and should be considered to reduce DCP location errors, mainly in high solar activity periods, while in those due to tropospheric effects the zenith errors are about threemeters. Therefore it is shown that the platform location errors can be reduced when the ionospheric and tropospheric effects are properly considered.

  12. An integrated assessment of the catchment-scale energy and water balance using a terrestrial systems modeling platform and observations

    Science.gov (United States)

    Sulis, Mauro; Shrestha, Prabhakar; Keune, Jessica; Steinke, Sandra; Diederich, Malte; Schween, Jan; Crewell, Susanne; Simmer, Clemens; Kollet, Stefan

    2016-04-01

    Fully coupled hydrological models close the water and energy cycles while accounting for the dynamic feedbacks between the subsurface, land surface, and atmosphere compartments of terrestrial systems. Diagnoses of their predictive capabilities require spatio-temporal coherent data sets including states and fluxes across the soil-vegetation-atmosphere continuum. This study presents an extensive comparison between numerical simulations carried out using a novel integrated hydrological modeling platform (TerrSysMP) and a suite of cross-compartmental observations obtained from intensive field campaigns and continuous monitoring over the Rur catchment in western Germany during the HOPE experiment (April-May 2013). The observations encompass amongst others rainfall estimates from several X-band radars, atmospheric integrated water vapor estimates from microwave radiometers, radiation and turbulent fluxes at the land surface, and soil moisture retrieval from cosmic-ray probes. A detailed analysis of the radiation components indicates that TerrSysMP systematically overestimates incoming shortwave due to a cloudiness effect, but underestimates incoming longwave due to a lower simulated atmospheric water vapor content. Screening of observed and simulated data for clear sky conditions also reveals mismatches between surface albedo at certain locations within the catchment. Moreover, a preliminary cross-comparison of precipitation and soil moisture suggests that overall the model is able to reproduce catchment dynamics reasonably well while pronounced discrepancies between model and observations were observed in the mountainous region due to the lack of detailed soil parameterization (i.e., soil organic content) and the underestimation of some rainfall events.

  13. Assessment of alkoxylphenacyl-based polycarbonates as a potential platform for controlled delivery of a model anti-glaucoma drug.

    Science.gov (United States)

    Manickavasagam, Dharani; Wehrung, Daniel; Chamsaz, Elaheh A; Sanders, Matthew; Bouhenni, Rachida; Crish, Samuel D; Joy, Abraham; Oyewumi, Moses O

    2016-10-01

    Treatment strategies for glaucoma will benefit from injectable and/or implantable delivery systems that can achieve sustained delivery of neuroprotective agents (to the posterior segment) and/or intraocular pressure lowering drugs (to the anterior segment). In this regard, we have evaluated the suitability of a new polymer (alkoxylphenacyl-based polycarbonates copolymer with polycaprolactone; AP-PCL 20% w/w) as a platform for ocular drug delivery. Brimonidine tartrate (BRT) was applied as a model anti-glaucoma drug. The polymer was applied to develop injectable (nanoparticles) and implantable (microfilms) delivery systems. Nanoparticles fabricated from AP-PCL were stable and have an average size less than 200nm. The AP-PCL microfilms prepared by compression molding showed a gradual hydrolytic in-vitro degradation monitored by water uptake, weight loss, microscopy, DSC and FT-IR measurements. AP-PCL microfilms achieve sustained delivery of BRT for up to 90days. Biocompatibility of AP-PCL-based delivery systems was demonstrated from studies in human trabecular meshwork cell line as well as after intravitreal injections in rats. The overall trend demonstrated that AP-PCL delivery systems may be considered as suitable candidates for prolonged drug delivery in chronic ocular disorders such as glaucoma. PMID:27320697

  14. The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies

    DEFF Research Database (Denmark)

    Ye, Ying; Carlsson, Göran; Karlsson-Sjöberg, Jenny M T;

    2015-01-01

    The underlying cause of neutropenia may be difficult to determine due to similar clinical presentation in many neutropenic conditions. The neutrophil protein hCAP-18 (pro-LL-37) is a major component of neutrophil secondary granules and in this prospective study we assessed the use of hCAP-18 levels...... in blood plasma for differential diagnosis of neutropenic patients (n = 133) of various aetiologies. Plasma levels of hCAP-18 were determined using immunoblot and ELISA. Patients with severe congenital neutropenia (n = 23) presented with the lowest levels of plasma hCAP-18 and differential diagnostic...... diagnostic value in differential diagnosis of chronic neutropenia. Neutropenic patients with Shwachman-Diamond syndrome, Barth syndrome, Cohen syndrome, acute myeloid leukaemia and specific granule deficiency presented with reduced plasma hCAP-18 levels as well. The blood plasma level of hCAP-18 was thus low...

  15. A comprehensive approach to assess Arabidopsis survival phenotype in water-limited condition using a non-invasive high-throughput phenomics platform

    Directory of Open Access Journals (Sweden)

    Emilio eVello

    2015-12-01

    Full Text Available With the rapid rise in global population and the challenges caused by climate changes, the maximization of plant productivity and the development of sustainable agriculture strategies are vital for food security. One of the resources more affected in this new environment will be the limitation of water.In this study, we describe the use of non-invasive technologies exploiting sensors for visible, fluorescent and near-infrared lights to accurately screen survival phenotypes in Arabidopsis thaliana exposed to water-limited conditions. We implemented two drought protocols and a robust analysis methodology that enabled us to clearly assess the wilting or dryness status of the plants at different time points using a phenomics platform. In conclusion, our approach has shown to be very accurate and suitable for experiments where hundred of samples have to be screened making a manual evaluation unthinkable. This approach can be used not only in functional genomics studies but also in agricultural applications.

  16. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels;

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden...... GPS box with data connection to a backend server. The ITS Platform project has had a budget of DKK 33 million (app € 4.4) and it has demonstrated that boxes which register the position of the cars can be helpful to drivers in many ways. Establishing dynamic traffic information and support systems...... for safer and more economic driving is technologically possible. Big Data from the system can provide traffic authorities with a better basis for decision for their traffic planning. Last, but not least, it is possible to establish payment systems. The project has also shown that the boxes in the cars do...

  17. Nano-CeO2 decorated graphene based chitosan nanocomposites as enzymatic biosensing platform: fabrication and cellular biocompatibility assessment.

    Science.gov (United States)

    De, Sriparna; Mohanty, Smita; Nayak, Sanjay Kumar

    2015-09-01

    The present study summarizes the designing of a green transducer phase based on nano-cerium oxide (CeO2) decorated reduced graphene oxide (RGO) reinforced chitosan nanocomposites as an effective enzyme immobilizer and bio-sensing matrix for glucose analyte. Also, it scrutinizes the biocompatibility and cell viability of the synthesized nanohybrid with human fibroblastic macrophage cell line. CeO2 nanoparticles (NPs) were successfully grown on graphene nanosheet in the presence of cationic surfactant followed by facile hydrothermal treatment. The eventual growth of synthesized CeO2 nanocrystals on the graphene layer was confirmed from X-ray diffraction (XRD), transmission electron microscopy (TEM) and Raman analysis. The biocompatibility of the synthesized nanohybrid was also evident from the MTT assay. Glucose oxidase (GOx) was employed on the green polymer nanocomposites modified FTO electrode to fabricate an enzymatic bioelectrode. The electroanalytical response of the GOx/nano-CeO2/RGO/CS/FTO bioelectrode towards electrooxidation of glucose analyte was investigated by electrochemical impedance (EIS) and cyclic voltammetry (CV) study. The resulting biosensor exhibited a good electrochemical response to glucose within the linear detection range of 0.05-6.5 mM with a low detection limit of 2 μM and a sensitivity of 7.198 μA mM(-1) cm(-2). The bioelectrode also showed good shelf life (~10 weeks) and negligible interfering ability under controlled environment. The obtained results indicate that nano-CeO2/RGO nanohybrid based chitosan nanocomposites achieve a biocompatible biosensing platform for effective enzyme immobilization due to the excellent synergistic effects between the CeO2 nanoparticles and graphene sheet.

  18. Federal mandatory spending caps vital for health care reform.

    Science.gov (United States)

    Domenici, P V

    1992-01-01

    Rising health spending creates an increasing burden on families, businesses, and government. Federal health spending--chiefly on Medicare and Medicaid--is a major contributor to a budget deficit that threatens to exceed $400 billion. In order to control that deficit, the President and the Congress must cap mandatory spending, excluding Social Security. In turn, policymakers should adopt health reforms to fit spending within the cap including enrolling more consumers in managed care plans, resolving medical liability disputes in arbitration instead of courts, and increasing assessment of research into cost-effective new technology.

  19. ATLAS End Cap toroid in upstanding position

    CERN Multimedia

    2005-01-01

    End Cap toroid The ATLAS End Cap toroid weights 240-ton and is 12-m diameter high. The parts of this vacuum vessel had to be integrated and tested so that End Cap Toroid has no leaks. After that it could be cooled down to 80 K.

  20. Analyses of hydraulic performance of velocity caps

    DEFF Research Database (Denmark)

    Christensen, Erik Damgaard; Degn Eskesen, Mark Chr.; Buhrkall, Jeppe;

    2014-01-01

    The hydraulic performance of a velocity cap has been investigated. Velocity caps are often used in connection with offshore intakes. CFD (computational fluid dynamics) examined the flow through the cap openings and further down into the intake pipes. This was combined with dimension analyses...

  1. 21 CFR 888.3000 - Bone cap.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Bone cap. 888.3000 Section 888.3000 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3000 Bone cap. (a) Identification. A bone cap is a...

  2. Dynamic Modeling of an Evapotranspiration Cap

    Energy Technology Data Exchange (ETDEWEB)

    Jacob J. Jacobson; Steven Piet; Rafael Soto; Gerald Sehlke; Harold Heydt; John Visser

    2005-10-01

    The U.S. Department of Energy is scheduled to design and install hundreds of landfill caps/barriers over the next several decades and these caps will have a design life expectancy of up to 1,000 years. Other landfill caps with 30 year design lifetimes are reaching the end of their original design life; the changes to these caps need to be understood to provide a basis for lifetime extension. Defining the attributes that make a successful cap (one that isolates the waste from the environment) is crucial to these efforts. Because cap systems such as landfill caps are dynamic in nature, it is impossible to understand, monitor, and update lifetime predictions without understanding the dynamics of cap degradation, which is most often due to multiple interdependent factors rather than isolated independent events. In an attempt to understand the dynamics of cap degradation, a computer model using system dynamics is being developed to capture the complex behavior of an evapotranspiration cap. The specific objectives of this project are to capture the dynamic, nonlinear feedback loop structures underlying an evapotranspiration cap and, through computer simulation, gain a better understanding of long-term behavior, influencing factors, and, ultimately, long-term cap performance.

  3. The online Prescriptive Index platform for the assessment of managerial competencies and coaching needs: development and initial validation of the experience sampling Mood Wheel and the Manager-Rational and Irrational Beliefs Scale

    OpenAIRE

    David, O.A.

    2013-01-01

    The Prescriptive Index platform is dedicated to the appraisal and development of managerial competencies, and it is comprised of such measures as the multi-rater Freeman-Gavita Prescriptive Executive Coaching (PEC) Assessment for assessing core managerial skills, and the multi-rater Managerial Coaching Assessment System (MCAS) for the evaluation of coaching competencies in managers. The aim of this research was to present the development and psychometric properties of new tools, part of the P...

  4. Economic evaluation of closure cap barrier materials study

    International Nuclear Information System (INIS)

    Volume II of the Economic Evaluation of the Closure Cap Barrier Materials, Revision I contains detailed cost estimates for closure cap barrier materials. The cost estimates incorporate the life cycle costs for a generic hazardous waste seepage basin closure cap under the RCRA Post Closure Period of thirty years. The economic evaluation assessed six barrier material categories. Each of these categories consists of several composite cover system configurations, which were used to develop individual cost estimates. The information contained in this report is not intended to be used as a cost estimating manual. This information provides the decision makers with the ability to screen barrier materials, cover system configurations, and identify cost-effective materials for further consideration

  5. Economic evaluation of closure cap barrier materials study

    Energy Technology Data Exchange (ETDEWEB)

    Serrato, M.G.; Bhutani, J.S.; Mead, S.M.

    1993-09-01

    Volume II of the Economic Evaluation of the Closure Cap Barrier Materials, Revision I contains detailed cost estimates for closure cap barrier materials. The cost estimates incorporate the life cycle costs for a generic hazardous waste seepage basin closure cap under the RCRA Post Closure Period of thirty years. The economic evaluation assessed six barrier material categories. Each of these categories consists of several composite cover system configurations, which were used to develop individual cost estimates. The information contained in this report is not intended to be used as a cost estimating manual. This information provides the decision makers with the ability to screen barrier materials, cover system configurations, and identify cost-effective materials for further consideration.

  6. Traceability and the new CAP

    OpenAIRE

    Maraveyas, Napoleon N.; Doukas, Yannis El.

    2009-01-01

    The Common Agricultural Policy (CAP) was strongly criticized for the food safety crises of the 1990s which included Bovine Spongiform Encephalopathy (BSE), dioxin, foot and mouth disease and swine fever to name a few. Even though the first rules on food safety date from the very early days of the EU, a need was recognized to replace a number of these rules accumulated through the years, whose implementation was difficult to monitor, with a simpler and more comprehensive approach. The result w...

  7. Two-phase synthesis of hydrophobic ionic liquid-capped gold nanoparticles and their application for sensing cholesterol

    International Nuclear Information System (INIS)

    Highlights: • A novel cholesterol biosensor was constructed based on ChOx-IL-capped-AuNPs/GCE. • IL-capped-AuNPs was synthesized using two-phase synthesis and employed as a conducting matrix to immobilize ChOx. • Direct electrochemistry of ChOx on the electrode was obtained. • The ChOx-IL-capped-AuNPs/GCE exhibit remarkable performance for cholesterol detection. - Abstract: A novel scheme for fabrication of hydrophobic ionic liquid-capped gold nanoparticles (IL-capped AuNPs) modified electrode is presented and its application potential for cholesterol biosensor is investigated. Highly stable gold nanoparticles were characterized by UV–vis absorption spectroscopy and transmission electron microscopy (TEM). Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) indicated that IL-capped AuNPs nanocomposites showed excellent electrical conductivity. Furthermore, cholesterol oxidase (ChOx) was directly immobilized on the IL-capped AuNPs nanocomposite, and then the direct electrochemistry of ChOx on the modified glass carbon electrode (GCE) was obtained. As a new platform in cholesterol analysis, ChOx-IL-capped AuNPs/GCE exhibited a linear response to cholesterol in the range of 0.1–50 μM with a detection limit of 0.033 μM. Therefore, hydrophobic ionic liquid-capped gold nanoparticles would serve as a good candidate material to construct the related enzyme biosensors

  8. Assessment of Registration Information on Methodological Design of Acupuncture RCTs: A Review of 453 Registration Records Retrieved from WHO International Clinical Trials Registry Platform.

    Science.gov (United States)

    Gu, Jing; Wang, Qi; Wang, Xiaogang; Li, Hailong; Gu, Mei; Ming, Haixia; Dong, Xiaoli; Yang, Kehu; Wu, Hongyan

    2014-01-01

    Background. This review provides the first methodological information assessment of protocol of acupuncture RCTs registered in WHO International Clinical Trials Registry Platform (ICTRP). Methods. All records of acupuncture RCTs registered in the ICTRP have been collected. The methodological design assessment involved whether the randomization methods, allocation concealment, and blinding were adequate or not based on the information of registration records (protocols of acupuncture RCTs). Results. A total of 453 records, found in 11 registries, were examined. Methodological details were insufficient in registration records; there were 76.4%, 89.0%, and 21.4% records that did not provide information on randomization methods, allocation concealment, and blinding respectively. The proportions of adequate randomization methods, allocation concealment, and blinding were only 107 (23.6%), 48 (10.6%), and 210 (46.4%), respectively. The methodological design improved year by year, especially after 2007. Additionally, methodology of RCTs with ethics approval was clearly superior to those without ethics approval and different among registries. Conclusions. The overall methodological design based on registration records of acupuncture RCTs is not very well but improved year by year. The insufficient information on randomization methods, allocation concealment, and blinding maybe due to the relevant description is not taken seriously in acupuncture RCTs' registration.

  9. 基于AHP的应急平台信息安全风险评估%ASSESSING INFORMATION SECURITY RISK OF THE EMERGENCY PLATFORM BASED ON AHP

    Institute of Scientific and Technical Information of China (English)

    张永妹; 王瑛; 李树仁; 党德鹏; 武建军

    2009-01-01

    Assessing information security risk of the emergency platform is a key task for its construction in China. Various risk values are determined by analyzing information security risk elements, applying AHP and constructing risk Hierarchy structure model, combining with constructed risk assessment math model. It is very important to avoid, reduce and transfer the security risk and strengthen security.%应急平台信息安全风险评估是我国应急平台建设工作重点任务之一.分析了应急平台信息安全风险要素,运用层次分析法,构建风险层次结构模型,结合构造的风险评估数学模型,最终确定了应急平台所面临的各类风险值.根据分析结果对应急平台安全风险进行规避,降低,转移,对加强应急平台安全具有重要意义.

  10. Platforms for Building and Deploying Applications for Cloud Computing

    CERN Document Server

    Buyya, Rajkumar

    2011-01-01

    Cloud computing is rapidly emerging as a new paradigm for delivering IT services as utlity-oriented services on subscription-basis. The rapid development of applications and their deployment in Cloud computing environments in efficient manner is a complex task. In this article, we give a brief introduction to Cloud computing technology and Platform as a Service, we examine the offerings in this category, and provide the basis for helping readers to understand basic application platform opportunities in Cloud by technologies such as Microsoft Azure, Sales Force, Google App, and Aneka for Cloud computing. We demonstrate that Manjrasoft Aneka is a Cloud Application Platform (CAP) leveraging these concepts and allowing an easy development of Cloud ready applications on a Private/Public/Hybrid Cloud. Aneka CAP offers facilities for quickly developing Cloud applications and a modular platform where additional services can be easily integrated to extend the system capabilities, thus being at pace with the rapidly ev...

  11. Assessing the impact of common forensic presumptive tests on the ability to obtain results using a novel rapid DNA platform.

    Science.gov (United States)

    Donachie, Gillian E; Dawnay, Nick; Ahmed, Romana; Naif, Sarah; Duxbury, Nicola J; Tribble, Nicholas D

    2015-07-01

    The rise of DNA evidence to the forefront of forensic science has led to high sample numbers being submitted for profiling by investigators to casework laboratories: bottleneck effects are often seen resulting in slow turnaround times and sample backlog. The ParaDNA(®) Screening and Intelligence Tests have been designed to guide investigators on the viability of potential sources of DNA allowing them to determine which samples should be sent for full DNA analysis. Both tests are designed to augment the arsenal of available forensic tests for end users and be used concurrently to those commonly available. Therefore, assessing the impact that common forensic tests have on such novel technology is important to measure. The systems were tested against various potential inhibitors to which samples may be exposed as part of the investigative process. Presumptive test agents for biological materials (blood, semen and saliva) and those used as fingerprint enhancement agents were both used. The Screening Test showed a drop in performance following application of aluminium powder and cyanoacrylate (CNA) on fingerprints samples; however this drop in performance was not replicated with high template DNA. No significant effect was observed for any agent using the Intelligence Test. Therefore, both tests stand up well to the chemical agents applied and can be used by investigators with confidence that system performance will be maintained. PMID:25864157

  12. Assessing the impact of common forensic presumptive tests on the ability to obtain results using a novel rapid DNA platform.

    Science.gov (United States)

    Donachie, Gillian E; Dawnay, Nick; Ahmed, Romana; Naif, Sarah; Duxbury, Nicola J; Tribble, Nicholas D

    2015-07-01

    The rise of DNA evidence to the forefront of forensic science has led to high sample numbers being submitted for profiling by investigators to casework laboratories: bottleneck effects are often seen resulting in slow turnaround times and sample backlog. The ParaDNA(®) Screening and Intelligence Tests have been designed to guide investigators on the viability of potential sources of DNA allowing them to determine which samples should be sent for full DNA analysis. Both tests are designed to augment the arsenal of available forensic tests for end users and be used concurrently to those commonly available. Therefore, assessing the impact that common forensic tests have on such novel technology is important to measure. The systems were tested against various potential inhibitors to which samples may be exposed as part of the investigative process. Presumptive test agents for biological materials (blood, semen and saliva) and those used as fingerprint enhancement agents were both used. The Screening Test showed a drop in performance following application of aluminium powder and cyanoacrylate (CNA) on fingerprints samples; however this drop in performance was not replicated with high template DNA. No significant effect was observed for any agent using the Intelligence Test. Therefore, both tests stand up well to the chemical agents applied and can be used by investigators with confidence that system performance will be maintained.

  13. Platform christened

    International Nuclear Information System (INIS)

    On Friday May 9, 1997, a ceremony took place in which the Hibernia platform was officially christened by Aline Chretien, the wife of the Prime Minister of Canada. The ceremony highlighted the successful completion of Hibernia and the tremendous accomplishment of this offshore structure which will be towed out of Bull Arm, Newfoundland, in June 1997 to its offshore location. Drilling for the first well will begin in August with first oil expected by December 1997. Other guests at the ceremony included Hibernia owner companies Mobil Oil, Chevron, Petro-Canada, Canada Hibernia Holding Corp., Murphy Oil and Norsk Hydro. The Hibernia project paves the way for other offshore ventures and employment opportunities in Newfoundland

  14. Coupled Large Scale Hydro-mechanical Modelling for cap-rock Failure Risk Assessment of CO{sub 2} Storage in Deep Saline Aquifers; Analyse hydromecanique a grande echelle pour l'evaluation du risque de fracturation de la couverture de stockage du CO{sub 2} dans les aquiferes profonds

    Energy Technology Data Exchange (ETDEWEB)

    Rohmer, J.; Seyedi, D.M. [BRGM, Natural Risks and CO 2 Storage Safety Division, 45 - Orleans (France)

    2010-05-15

    This work presents a numerical strategy of large scale hydro-mechanical simulations to assess the risk of damage in cap-rock formations during a CO{sub 2} injection process. The proposed methodology is based on the development of a sequential coupling between a multiphase fluid flow (TOUGH2) and a hydro-mechanical calculation code (Code-Aster) that enables us to perform coupled hydro-mechanical simulation at a regional scale. The likelihood of different cap-rock damage mechanisms can then be evaluated based on the results of the coupled simulations. A scenario based approach is proposed to take into account the effect of the uncertainty of model parameters on damage likelihood. The developed methodology is applied for the cap-rock failure analysis of deep aquifer of the Dogger formation in the context of the Paris basin multilayered geological system as a demonstration example. The simulation is carried out at a regional scale (100 km) considering an industrial mass injection rate of CO{sub 2} of 10 Mt/y. The assessment of the stress state after 10 years of injection is conducted through the developed sequential coupling. Two failure mechanisms have been taken into account, namely the tensile fracturing and the shear slip reactivation of pre-existing fractures. To deal with the large uncertainties due to sparse data on the layer formations, a scenario based strategy is undertaken. It consists in defining a first reference modelling scenario considering the mean values of the hydro-mechanical properties for each layer. A sensitivity analysis is then carried out and shows the importance of both the initial stress state and the reservoir hydraulic properties on the cap-rock failure tendency. On this basis, a second scenario denoted 'critical' is defined so that the most influential model parameters are taken in their worst configuration. None of these failure criteria is activated for the considered conditions. At a phenomenological level, this study points

  15. The online Prescriptive Index platform for the assessment of managerial competencies and coaching needs: development and initial validation of the experience sampling Mood Wheel and the Manager-Rational and Irrational Beliefs Scale

    Directory of Open Access Journals (Sweden)

    David, O.A.

    2013-12-01

    Full Text Available The Prescriptive Index platform is dedicated to the appraisal and development of managerial competencies, and it is comprised of such measures as the multi-rater Freeman-Gavita Prescriptive Executive Coaching (PEC Assessment for assessing core managerial skills, and the multi-rater Managerial Coaching Assessment System (MCAS for the evaluation of coaching competencies in managers. The aim of this research was to present the development and psychometric properties of new tools, part of the Prescriptive Index platform, for the assessment of managerial emotional competencies: the web and mobile based Mood Wheel measure using experience sampling procedures, for the assessment of current/previous distress and positive emotions; and the self-report Manager Rational and Irrational Beliefs Scale (M-RIBS for the assessment of managerial attitudes involved in emotion-regulation processes. Results obtained show that both instruments integrated in the Prescriptive Index platform have adequate initial psychometric support and predictive validity. Practical implications of our findings are discussed in the light of the importance of enabling organizations to accurately identify managerial competencies and coaching needs.

  16. Assessing fun in platform games

    OpenAIRE

    Diogo Ferreira Pinela

    2015-01-01

    Os jogos de plataformas são um dos géneros mais antigos de videojogos, e têm ganho popularidade recentemente devido às suas mecânicas simples. No entanto, podem tornar-se repetitivos depois de terminados, pelo que podem beneficiar significativamente do uso de geração procedimental de conteúdos, estendendo a sua duração sem aborrecer o jogador. Há vários métodos para gerar níveis procedimentalmente; alguns juntam componentes de baixo nível diretamente, enquanto outros baseiam as suas construçõ...

  17. Collapse mechanisms and strength prediction of reinforced concrete pile caps

    DEFF Research Database (Denmark)

    Jensen, Uffe G.; Hoang, Linh Cao

    2012-01-01

    This paper describes an upper bound plasticity approach for strength prediction of reinforced concrete pile caps. A number of collapse mechanisms are identified and analysed. The procedure leads to an estimate of the load-carrying capacity and an identification of the critical collapse mechanism........ It is argued that the upper bound approach may be a useful complement to the widely used lower bound strut-and-tie method. Especially when dealing with strength assessment of existing structures....

  18. SERS sensors for DVD platform

    DEFF Research Database (Denmark)

    Brøgger, Anna Line

    This Ph.D. thesis explores the engineering of a portable sensor system for detection of rare and small molecules. The Ph.D. project is part of the research project 'Multi-Sensor DVD platform' (MUSE), aiming to integrate different sensors on a rotating disc. The sensors are chosen to complement each...... other, creating more reliable and stable results for the end user. The rotating disc comprises microfluidic channels, which can be utilized for handling and manipulating liquid samples such as blood or water. The focus of this Ph.D. thesis, is on the integration of one specific sensor on a rotating disc....... The sensor is based upon surface enhanced Raman spectroscopy (SERS), which detects molecular vibrations. The aim of this thesis is to cover the different aspects of the sensor system. SERS substrates, consisting of nanopillars with gold or silver caps on top, have been fabricated by standard micro and nano...

  19. Nature mangement, landscape and the CAP

    NARCIS (Netherlands)

    Brouwer, F.M.; Godeschalk, F.E.

    2004-01-01

    The integration of nature management, landscape and environmental concerns into the Common Agricultural Policy (CAP) has gained momentum with the CAP reforms adopted in June 2003. The report explores instruments and approaches that contribute to the inte-gration of nature conservation and landscape

  20. Robustness assessment of jacket platforms for progressive collapse under extreme environmental loading%极端环境下导管架平台连续倒塌鲁棒性评估

    Institute of Scientific and Technical Information of China (English)

    朱本瑞; 陈国明; 林红; 刘红兵; 胡春友

    2015-01-01

    The ultimate limit state and residual strength reserve ratio of jacket platforms were analyzed based on alternate path ( AP) and Pushover methods, and the influence of component types on platforms' anti-collapse capacity was investigated. The certainty indexes of WDSR , WRIF and WSRF were used to assess the robustness of jacket platforms as well as the importance of components. Considering the impact of environmental loading on the ultimate bearing capacity of jacket platforms, random plat-form reliability assessment method under random loading was established based on multi strips analysis ( MSA) and load se-quence incremental analysis (LSIA). Combining MSA and LSIA, a novel safety assessment figure (SAF) was proposed to e-valuate the safety of jacket platforms under full scale environmental loading. Further, probabilistic robustness of the platform was assessed utilizing probabilistic redundancy index. The results show that the resistance of the platform is not sensitive to the failure of horizontal bracings, which can be regarded as the redundant components because their deterministic robustness index is more significant. Diagonal bracings play an important role in ensuring the robustness of platform structures. The failure of this kind of components will affect the capacity of the platform. Therefore, it should be ensured that the strength and toughness are sufficient in the design of jacket platforms. The SAF introduced in this paper can improve the calculation precision of proba-bilistic robustness evaluation.%基于Pushover和AP法分析平台结构极限状态及剩余强度储备比,探讨不同类别承载模式的构件对平台结构抗倒塌能力的影响规律;采用WDSR、WRIF和WSRF确定性指标,评估平台结构鲁棒性和构件重要度.考虑平台抗力受环境载荷变化的影响,基于MSA和LSIA建立随机平台在随机载荷下的可靠度评估方法,提出导管架平台"安全评定图"概念,对服役平台全尺度载荷下的

  1. Microtubule dynamics: Caps, catastrophes, and coupled hydrolysis

    DEFF Research Database (Denmark)

    Flyvbjerg, H.; Holy, T.E.; Leibler, S.

    1996-01-01

    An effective theory is formulated for the dynamics of the guanosine triphosphate (GTP) cap believed to stabilize growing microtubules. The theory provides a ''coarse-grained'' description of the cap's dynamics. ''Microscopic'' details, such as the microtubule lattice structure and the fate of its...... data. A constant nonzero catastrophe rare, identical for both microtubule ends, is predicted at large growth rates. The delay time for dilution-induced catastrophes is stochastic with a simple distribution that fits the experimental one and, like the experimental one, does not depend on the rate of....... A recent experimental result for the size of the minimal cap that can stabilize a microtubule is shown to agree with the result predicted by the cap model, after its parameters have been extracted from previous experimental results. Thus the effective theory and cap model presented here provide a...

  2. Design document for landfill capping Prototype Decision Support System

    International Nuclear Information System (INIS)

    The overall objective of the Prototype Decision Support System for shallow land burial project is to ''Develop a Decision Support System tool which incorporates simulation modeling and multi-objective decision theory for the purpose of designing and evaluating alternative trench cap designs for mixed waste landfill covers. The goal is to improve the quality of technical information used by the risk manager to select landfill cover designs while taking into account technological, economical, and regulatory factors.'' The complexity of the technical and non-technical information, and how the information varies in importance across sites, points to the need for decision analysis tools that provide a common basis for integrating, synthesizing, and valuing the decision input. Because the cost of remediating thousands of contaminated DOE sites is projected to be in the 10's--100's of billions of dollars, methods will be needed to establish cleanup priorities and to help in the selection and evaluation of cost effective remediation alternatives. Even at this early stage in DOE's cleanup program, it is certain that capping technologies will be heavily relied upon to remediate the 3000+ landfills on DOE property. Capping is favored in remediating most DOE landfills because, based on preliminary baseline risk assessments, human and ecological risks are considered to be low at most of these sites and the regulatory requirements for final closure of old landfills can be met using a well designed cap to isolate the buried waste. This report describes a program plan to design, develop, and test a decision support system (DSS) for assisting the DOE risk manager in evaluating capping alternatives for radioactive and hazardous waste landfills. The DOE DSS will incorporate methods for calculating, integrating and valuing technical, regulatory, and economic criteria

  3. Google Search and the Law on Dominance in the EU: An Assessment of the Compatibility of Current Methodology with Multi-Sided Platforms in Online Search

    OpenAIRE

    Herz, Martin

    2014-01-01

    Business platforms that utilise, or are based upon, internet technology are omnipresent in consumers daily lives. Since the dawn of the World Wide Web, the amount of web content has increased greatly. Simultaneously, business interests have sparked, meeting the arisen demand for particular online services. As a consequence, economists have defined a novel market in these sectors, namely that of multi-sided platform markets. To an important extent, these markets experience network effects, whi...

  4. 78 FR 2600 - Special Access for Price Cap Local Exchange Carriers; AT&T Corporation Petition for Rulemaking To...

    Science.gov (United States)

    2013-01-11

    ... CFR Part 69 Special Access for Price Cap Local Exchange Carriers; AT&T Corporation Petition for Rulemaking To Reform Regulation of Incumbent Local Exchange Carrier Rates for Interstate Special Access... analytic framework capable of assessing whether the Commission's price cap and pricing flexibility...

  5. Possible Effects on EU Land Markets of New CAP Direct Payments

    OpenAIRE

    Swinnen, Jo; Ciaian, Pavel; Kancs, D'Artis; Van Herck, Kristine; Vranken, Liesbet

    2013-01-01

    Direct payments (DP) in the EU-27 were introduced as the central element of the 2003 CAP reform and are implemented in different models. The 2013 CAP reform will change both the implementation of the DP and their budget. This study assesses the possible effects of the DP reform proposals on EU land markets and the extent to which the DP are capitalized in land prices.

  6. Genetic ablation of root cap cells in Arabidopsis

    OpenAIRE

    Tsugeki, Ryuji; Fedoroff, Nina V.

    1999-01-01

    The root cap is increasingly appreciated as a complex and dynamic plant organ. Root caps sense and transmit environmental signals, synthesize and secrete small molecules and macromolecules, and in some species shed metabolically active cells. However, it is not known whether root caps are essential for normal shoot and root development. We report the identification of a root cap-specific promoter and describe its use to genetically ablate root caps by directing root cap-specific expression of...

  7. Population Files for use with CAP88 at Los Alamos

    Energy Technology Data Exchange (ETDEWEB)

    McNaughton, Michael W [Los Alamos National Laboratory; Brock, Burgandy R [Los Alamos National Laboratory

    2012-07-10

    CAP88 (Clean Air Act Assessment Package 1988) is a computer model developed for the US Environmental Protection Agency to assess the potential dose from radionuclide emissions to air and to demonstrate compliance with the Clean Air Act. It has options to calculate either individual doses, in units of mrem, or a collective dose, also called population dose, in units of person-rem. To calculate the collective dose, CAP88 uses a population file such as LANL.pop, that lists the number of people in each sector (N, NNE, NE, etc.) as a function of distance (1 to 2 km, etc.) out to a maximum radius of 80 km. Early population files are described in the Los Alamos National Laboratory (LANL) Environmental Reports for 1985 (page 14) and subsequent years. LA-13469-MS describes a population file based on the 1990 census. These files have been updated several times, most recently in 2006 for CAP88 version 3. The 2006 version used the US census for 2000. The present paper describes the 2012 updates, using the 2010 census.

  8. CAPS and INMS Major Accomplishments

    Science.gov (United States)

    Waite, J. Hunter

    2014-05-01

    The Cassini-Huygens Ion Neutral Mass Spectrometer (Cassini INMS) and the Cassini Plasma Spectrometer (CAPS) have provided "discovery" science at Titan, Enceladus, Rhea/Dione, and throughout the magnetosphere of Saturn during the course of the mission. In this talk we will review some of the major scientific achievements: 1) the discovery of an extremely complex ion neutral organic chemistry in Titan's upper atmosphere that forms the building blocks for aerosol processes below, 2) the discovery of gases and grains emanating from Enceladus' cryo-geysers that tell us about chemical processes in an interior sea, 3) the first direct compositional measurements of sputtered icy moon surfaces, 4) the clearest example to date of the complex plasma interchange processes that occur in rapidly rotating magnetospheres of gas giants, initiating global dynamic processes that enable Saturn to shed the plasma from Enceladus' plume, and complete with a myriad of longitudinal and solar local-time variations, and 5) the dominance of Enceladus water outgassing as a source of magnetospheric plasma that stretches out to Titan and provides oxygen that can convert Titan's rich nitrile populations into amino acids.

  9. The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests.

    Science.gov (United States)

    Mathaes, Roman; Mahler, Hanns-Christian; Buettiker, Jean-Pierre; Roehl, Holger; Lam, Philippe; Brown, Helen; Luemkemann, Joerg; Adler, Michael; Huwyler, Joerg; Streubel, Alexander; Mohl, Silke

    2016-02-01

    Parenteral drug products are protected by appropriate primary packaging to protect against environmental factors, including potential microbial contamination during shelf life duration. The most commonly used CCS configuration for parenteral drug products is the glass vial, sealed with a rubber stopper and an aluminum crimp cap. In combination with an adequately designed and controlled aseptic fill/finish processes, a well-designed and characterized capping process is indispensable to ensure product quality and integrity and to minimize rejections during the manufacturing process. In this review, the health authority requirements and expectations related to container closure system quality and container closure integrity are summarized. The pharmaceutical vial, the rubber stopper, and the crimp cap are described. Different capping techniques are critically compared: The most common capping equipment with a rotating capping plate produces the lowest amount of particle. The strength and challenges of methods to control the capping process are discussed. The residual seal force method can characterize the capping process independent of the used capping equipment or CCS. We analyze the root causes of several cosmetic defects associated with the vial capping process.

  10. Capping stack: An industry in the making

    Institute of Scientific and Technical Information of China (English)

    Jack Chen; Li Xunke; Xie Wenhui; Kang Yongtian

    2013-01-01

    This paper gives an overview of recent development of the marine well containment system (MWCS)after BP Macondo subsea well blowout occurred on April 20,2010 in the Gulf of Mexico.Capping stack,a hardware utilized to contain blowout well at or near the wellhead is the center piece of MWCS.Accessibility to the dedicated capping stacks is gradually becoming a pre-requirement to obtain the permit for offshore drilling/workover,and the industry for manufacturing,maintenance,transportation and operation of the capping stack is in the making.

  11. Circumpolar Active-Layer Permafrost System (CAPS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Circumpolar Active-Layer Permafrost System (CAPS) contains over 100 data sets pertaining to permafrost and frozen ground topics. It also contains detailed...

  12. C-CAP Land Cover, Niihau, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  13. C-CAP Land Cover, Molokai, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  14. C-CAP Land Cover, Lanai, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  15. Mapping of p140Cap phosphorylation sites

    DEFF Research Database (Denmark)

    Repetto, Daniele; Aramu, Simona; Boeri Erba, Elisabetta;

    2013-01-01

    protein, in which both EPLYA/EGLYA tyrosines were converted to phenylalanine, was no longer tyrosine phosphorylated, despite the presence of other tyrosine residues in p140Cap sequence. Moreover, this mutant lost its ability to bind the C-terminal Src kinase (Csk), previously shown to interact with p140...... phosphorylation and tunes its interactions with other regulatory molecules via post-translation modification. In this work, using mass spectrometry, we found that p140Cap is in vivo phosphorylated on tyrosine (Y) within the peptide GEGLpYADPYGLLHEGR (from now on referred to as EGLYA) as well as on three serine...... residues. Consistently, EGLYA has the highest score of in silico prediction of p140Cap phosphorylation. To further investigate the p140Cap function, we performed site specific mutagenesis on tyrosines inserted in EGLYA and EPLYA, a second sequence with the same highest score of phosphorylation. The mutant...

  16. C-CAP Hawaii 2005 Land Cover

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  17. C-CAP Land Cover, Maui, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  18. Reflection on Foreign Languages Network Teaching Platform

    Institute of Scientific and Technical Information of China (English)

    LIANG Yuan

    2014-01-01

    This paper aims to build awareness in applying foreign languages network teaching platform to higher education. Teachers rationally use foreign languages network teaching platform to hold an initiative concept, establish a cooperative and in-teractive learning atmosphere, and a prompt and dynamic assessment system.

  19. Design and implementation of the CAPS receiver

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this paper, based on analyses of the Chinese Area Positioning System (CAPS) satellite (GEO satellite) resources and signal properties, the signal power at the port of the receiver antenna is estimated, and the implementation projects are presented for a switching band C to band L CAPS C/A code receiver integrated with GPS receiver suite and for a CAPS dual frequency P code receiver. A microstrip receiving antenna is designed with high sensitivity and wide beam orientation, the RF front end of the C/A code and P code receivers, and a processor is designed for the navigation baseband. A single frequency CAPS C/A code receiver and a CAPS dual frequency P code receiver are built at the same time. A software process flow is provided, and research on relatively key techniques is also conducted, such as signal searching, code loop and carrier loop algorithms, a height assistant algorithm, a dual frequency difference speed measurement technique, a speed measurement technique using a single frequency source with frequency assistance, and a CAPS time correcting algorithm, according to the design frame of the receiver hardware. Research results show that the static plane positioning accuracy of the CAPS C/A code receiver is 20.5-24.6 m, height accuracy is 1.2-12.8 m, speed measurement accuracy is 0.13-0.3 m/s, dynamic plane positioning accuracy is 24.4 m, height accuracy is 3.0 m, and speed measurement accuracy is 0.24 m/s. In the case of C/A code, the timing accuracy is 200 ns, and it is also shown that the positioning accuracy of the CAPS precise code receiver (1σ ) is 5 m from south to north, and 0.8 m from east to west. Finally, research on positioning accuracy is also conducted.

  20. Mechanisms of nerve capping technique in prevention of painful neuroma formation.

    Directory of Open Access Journals (Sweden)

    Hede Yan

    Full Text Available Nerve capping techniques have been introduced as a promising treatment modality for the treatment of painful neuroma with varied outcomes; however, its exact mechanism is still unknown. RhoA is one of the members of the RAS superfamily of GTPases that operate as molecular switches and plays an important role in peripheral nerve regeneration. Our aim was to investigate the structural and morphologic mechanisms by which the nerve capping technique prevents the formation of painful neuromas after neuroectomy. We also hoped to provide a theoretical basis for this treatment approach. An aligned nanofiber conduit was used for the capping procedure and the sciatic nerve of Sprague-Dawley rats was selected as the animal model. Behavioral analysis, extent of neuroma formation, histological assessment, expressions of pain markers of substance P and c-fos, molecular biological changes as well as ultrastructural features were investigated and compared with the findings in a no-capping control group. The formation of traumatic neuromas was significantly inhibited in the capping group with relatively "normal" structural and morphological features and no occurrence of autotomy and significantly lower expression of pain markers compared to the no-capping group. The gene expression of RhoA was consistently in a higher level in the capping group within 8 weeks after surgery. This study shows that capping technique will alter the regeneration state of transected nerves and reduce painful neuroma formation, indicating a promising approach for the treatment of painful neuroma. The initiation of the "regenerative brake" induced by structural as well as morphological improvements in the severed nerve is theorized to be most likely a key mechanism for the capping technique in the prevention of painful neuroma formation.

  1. Google Search and the Law on Dominance in the EU : An Assessment of the Compatibility of Current Methodology with Multi-Sided Platforms in Online Search

    NARCIS (Netherlands)

    Herz, Martin

    2014-01-01

    Business platforms that utilise, or are based upon, internet technology are omnipresent in consumers daily lives. Since the dawn of the World Wide Web, the amount of web content has increased greatly. Simultaneously, business interests have sparked, meeting the arisen demand for particular online se

  2. Succinic acid production derived from carbohydrates: An energy and greenhouse gas assessment of a platform chemical toward a bio-based economy

    NARCIS (Netherlands)

    Cok, B.; Tsiropoulos, I.; Roes, A.L.; Patel, M.K.

    2014-01-01

    Bio-based succinic acid has the potential to become a platform chemical, i.e. a key building block for deriving both commodity and high-value chemicals, which makes it an attractive compound in a bio-based economy. A few companies and industrial consortia have begun to develop its industrial product

  3. ITS Platform North Denmark

    DEFF Research Database (Denmark)

    Lahrmann, Harry; Agerholm, Niels; Juhl, Jens;

    2012-01-01

    This paper presents the project entitled “ITS Platform North Denmark” which is used as a test platform for Intelligent Transportation System (ITS) solutions. The platform consists of a newly developed GNSS/GPRS On Board Unit (OBU) to be installed in 500 cars, a backend server and a specially...... designed digital road map for ITS applications. The platform is freely accessible, which means that third party applications could be run on the platform. It is estimated that using this platform enables the ITS applications to be developed for 20% of the normal cost, hence third party are invited to test...... their applications in this platform. This paper presents the platform’s potentials and explains a series of test applications which are under development on it. Moreover, a number of new projects planned for the platform are demonstrated....

  4. 75 FR 49527 - Caps Visual Communications, LLC; Black Dot Group; Formerly Known as Caps Group Acquisition, LLC...

    Science.gov (United States)

    2010-08-13

    ... Employment and Training Administration Caps Visual Communications, LLC; Black Dot Group; Formerly Known as... Adjustment Assistance on June 24, 2010, applicable to workers of Caps Visual Communications, LLC, Black Dot..., Caps Visual Communications, LLC, Black Dot Group, formerly known as Caps Group Acquisition,...

  5. Platform development supportedby gaming

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan; Hansen, Poul H. Kyvsgård

    2007-01-01

    , possibly increasing the strategic risks for the firm. This paper reports preliminary findings on platform management process at LEGO, a Danish toy company.  Specifically, we report the process of applying games combined with simulations and workshops in the platform development. We also propose a framework......, based on the portfolio management thinking, to measure the degree of modularity embedded in a given platform and to what extent it is aligned with other platforms....

  6. Mobile platform security

    CERN Document Server

    Asokan, N; Dmitrienko, Alexandra

    2013-01-01

    Recently, mobile security has garnered considerable interest in both the research community and industry due to the popularity of smartphones. The current smartphone platforms are open systems that allow application development, also for malicious parties. To protect the mobile device, its user, and other mobile ecosystem stakeholders such as network operators, application execution is controlled by a platform security architecture. This book explores how such mobile platform security architectures work. We present a generic model for mobile platform security architectures: the model illustrat

  7. Guidance for summarising and evaluating field studies with non-target arthropods : aguidance document of the Dutch Platform for the Assessment of Higher Tier Studies

    OpenAIRE

    Jong, de, J.; Steen, van der, M.

    2010-01-01

    Gewasbeschermingsmiddelen kunnen schadelijke effecten hebben op organismen waarvoor ze niet zijn bedoeld. Er is een richtsnoer ontwikkeld om testresultaten voor de toelatingsprocedure voor gewasbeschermingsmiddelen eenvormig en transparant aan te reiken. Het richtsnoer geldt specifiek voor veldstudies met niet-doelwit arthropoden (geleedpotigen) die boven de grond en op planten leven, bijvoorbeeld in akkers of boomgaarden. Het richtsnoer is ontwikkeld door het Nederlandse Platform voor de Beo...

  8. Scenarios for a cap beyond 2013; Implications for EU27 agriculture and the cap budget

    NARCIS (Netherlands)

    Helming, J.F.M.; Terluin, I.J.

    2011-01-01

    An ex ante analysis of a set of five policy components (proposed post 2013 CAP measures) has been carried out for the 2014-2020 period, based on the EC Communication The CAP towards 2020 of 18 November 2010. The policy components are defined in such a way that they focus on the contribution of farme

  9. Ability of combined Near-Infrared Spectroscopy-Intravascular Ultrasound (NIRS-IVUS) imaging to detect lipid core plaques and estimate cap thickness in human autopsy coronary arteries

    Science.gov (United States)

    Grainger, S. J.; Su, J. L.; Greiner, C. A.; Saybolt, M. D.; Wilensky, R. L.; Raichlen, J. S.; Madden, S. P.; Muller, J. E.

    2016-03-01

    The ability to determine plaque cap thickness during catheterization is thought to be of clinical importance for plaque vulnerability assessment. While methods to compositionally assess cap integrity are in development, a method utilizing currently available tools to measure cap thickness is highly desirable. NIRS-IVUS is a commercially available dual imaging method in current clinical use that may provide cap thickness information to the skilled reader; however, this is as yet unproven. Ten autopsy hearts (n=15 arterial segments) were scanned with the multimodality NIRS-IVUS catheter (TVC Imaging System, Infraredx, Inc.) to identify lipid core plaques (LCPs). Skilled readers made predictions of cap thickness over regions of chemogram LCP, using NIRS-IVUS. Artery segments were perfusion fixed and cut into 2 mm serial blocks. Thin sections stained with Movat's pentachrome were analyzed for cap thickness at LCP regions. Block level predictions were compared to histology, as classified by a blinded pathologist. Within 15 arterial segments, 117 chemogram blocks were found by NIRS to contain LCP. Utilizing NIRSIVUS, chemogram blocks were divided into 4 categories: thin capped fibroatheromas (TCFA), thick capped fibroatheromas (ThCFA), pathological intimal thickening (PIT)/lipid pool (no defined cap), and calcified/unable to determine cap thickness. Sensitivities/specificities for thin cap fibroatheromas, thick cap fibroatheromas, and PIT/lipid pools were 0.54/0.99, 0.68/0.88, and 0.80/0.97, respectively. The overall accuracy rate was 70.1% (including 22 blocks unable to predict, p = 0.075). In the absence of calcium, NIRS-IVUS imaging provided predictions of cap thickness over LCP with moderate accuracy. The ability of this multimodality imaging method to identify vulnerable coronary plaques requires further assessment in both larger autopsy studies, and clinical studies in patients undergoing NIRS-IVUS imaging.

  10. Atmospheric metallic and arsenic pollution at an offshore drilling platform in the Bo Sea: A health risk assessment for the workers.

    Science.gov (United States)

    Xu, Hong; Han, Suqin; Bi, Xiaohui; Zhao, Zhijing; Zhang, Lei; Yang, Wenjie; Zhang, Min; Chen, Jing; Wu, Jianhui; Zhang, Yufen; Feng, Yinchang

    2016-03-01

    To investigate the ambient metal pollution at the offshore drilling platform in the Bo Sea, which few studies have focused on, PM2.5 samples were collected and ten heavy metals, as well as As, were analyzed. High concentration levels of metals were observed, and the heavy metal pollution was quite serious compared to air quality standards and other marine areas. Back trajectories and wind dependent and PCA analyses showed that the marine sources included ship traffic emissions and corrosive stainless steels from the equipment at the platform as well as industrial emissions from stainless steel production and coal combustion sources, which were transported from the surrounding mainland. Both contributed greatly to the ambient metallic particles at the offshore platform. The Hazard Index values of the metals, which were much less than 1, the Carcinogenic Risk data, which were lower than the EPA's acceptable range, and the fact that the metal concentrations did not the exceed the permissible exposure limits of OSHA, indicated that the health risks from the ambient metallic particles for the oil-drilling workers were not significant.

  11. Atmospheric metallic and arsenic pollution at an offshore drilling platform in the Bo Sea: A health risk assessment for the workers.

    Science.gov (United States)

    Xu, Hong; Han, Suqin; Bi, Xiaohui; Zhao, Zhijing; Zhang, Lei; Yang, Wenjie; Zhang, Min; Chen, Jing; Wu, Jianhui; Zhang, Yufen; Feng, Yinchang

    2016-03-01

    To investigate the ambient metal pollution at the offshore drilling platform in the Bo Sea, which few studies have focused on, PM2.5 samples were collected and ten heavy metals, as well as As, were analyzed. High concentration levels of metals were observed, and the heavy metal pollution was quite serious compared to air quality standards and other marine areas. Back trajectories and wind dependent and PCA analyses showed that the marine sources included ship traffic emissions and corrosive stainless steels from the equipment at the platform as well as industrial emissions from stainless steel production and coal combustion sources, which were transported from the surrounding mainland. Both contributed greatly to the ambient metallic particles at the offshore platform. The Hazard Index values of the metals, which were much less than 1, the Carcinogenic Risk data, which were lower than the EPA's acceptable range, and the fact that the metal concentrations did not the exceed the permissible exposure limits of OSHA, indicated that the health risks from the ambient metallic particles for the oil-drilling workers were not significant. PMID:26547617

  12. Analysis on the positioning precision of CAPS

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    As a newly developed satellite positioning system, the Chinese Area Positioning System (CAPS) is a typical direct sequence spread spectrum ranging system like GPS. The positioning precision of such navigation signals depends on many factors, including the pseudo-code rate, the signal to noise ratio, the processing methods for tracking loops and so on. This paper describes the CAPS link budget, the solution approach for CAPS positioning, focusing on the autocorrelation function feature of C/A code signals. The CAPS signal measurement precision is studied by the software approach together with theoretical analysis of the range resolution. Because the conventional Delay Lock Loop (DLL) is vul- nerable to the impact of noise, a narrow correlator and multiple correlators as well as the corresponding discrimination methods of phases are proposed, which improves the robustness of DLL and the code-phase resolution of the measurement. The results show that the improvement of the DLL structure and the discrimination method are the most important way to improve the ranging resolution. Theoretical analysis and experimental results show that a CAPS receiver could reach a 20-m positioning precision by using three satellites with a supported height from an altimeter.

  13. Martian north polar cap summer water cycle

    CERN Document Server

    Brown, Adrian J; Becerra, Patricio; Byrne, Shane

    2016-01-01

    A key outstanding question in Martian science is 'are the polar caps gaining or losing mass and what are the implications for past, current and future climate?' To address this question, we use observations from the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) of the north polar cap during late summer for multiple Martian years, to monitor the summertime water cycle in order to place quantitative limits on the amount of water ice deposited and sublimed in late summer. We establish here for the first time the summer cycle of water ice absorption band signatures on the north polar cap. We show that in a key region in the interior of the north polar cap, the absorption band depths grow until Ls=120, when they begin to shrink, until they are obscured at the end of summer by the north polar hood. This behavior is transferable over the entire north polar cap, where in late summer regions 'flip' from being net sublimating into net condensation mode. This transition or 'mode flip' happens earlier for ...

  14. Analysis on the positioning precision of CAPS

    Institute of Scientific and Technical Information of China (English)

    JI YuanFa; SUN XiYan

    2009-01-01

    As a newly developed satellite positioning system,the Chinese Area Positioning System (CAPS) Is a typical direct sequence spread spectrum ranging system like GPS.The positioning precision of such navigation signals depends on many factors,including the pseudo-code rate,the signal to noise ratio,the processing methods for tracking loops and so on.This paper describes the CAPS link budget,the solution approach for CAPS positioning,focusing on the autocorrelation function feature of C/A code signals.The CAPS signal measurement precision is studied by the software approach together with theoretical analysis of the range resolution.Because the conventional Delay Lock Loop (DLL) is vulnerable to the impact of noise,a narrow correlator and multiple correlatore as well as the corresponding discrimination methods of phases are proposed,which improves the robustness of DLL and the code-phase resolution of the measurement.The results show that the Improvement of the DLL structure and the discrimination method are the most important way to improve the ranging resolution.Theoretical analysis and experimental results show that a CAPS receiver could reach a 20-m positioning precision by using three satellites with a supported height from an altimeter.

  15. [Experimental testing of centrally authorised medicinal products. The CAP programme].

    Science.gov (United States)

    Giess, S

    2014-10-01

    In addition to marketing authorisation, inspection and pharmacovigilance the experimental testing within the CAP programme provides another important instrument of assessing and testing centrally authorised medicinal products. Coordinated activities in European member states and institutions--including planning, sampling, lab testing, reporting and assessment of results--allow us to establish an effective quality control system for this group of innovative medicinal products. By means of using existing networks and national structures, unnecessary parallel sampling and testing can be avoided, and limited resources can be used in a better way. The CAP programme is an independent test and surveillance programme, which demonstrates the high quality of centrally authorised medicinal products in the EU/EEA. That way, it strengthens the confidence of patients and the public in these innovative medicinal products. Furthermore, it enables OMCLs to gain experience with new sensitive analytical methods, which can also be used in other areas, for example for the identification of counterfeits or the assessment of biosimilars and generics. PMID:25159224

  16. Product Platform Performance

    DEFF Research Database (Denmark)

    Munk, Lone

    The aim of this research is to improve understanding of platform-based product development by studying platform performance in relation to internal effects in companies. Platform-based product development makes it possible to deliver product variety and at the same time reduce the needed resources...... experienced representatives from the different life systems phase systems of the platform products. The effects are estimated and modeled within different scenarios, taking into account financial and real option aspects. The model illustrates and supports estimation and quantification of internal platform...

  17. Seismic explosion sources on an ice cap

    DEFF Research Database (Denmark)

    Shulgin, Alexey; Thybo, Hans

    2015-01-01

    Controlled source seismic investigation of crustal structure below ice covers is an emerging technique. We have recently conducted an explosive refraction/wide-angle reflection seismic experiment on the ice cap in east-central Greenland. The data-quality is high for all shot points and a full...... crustal model can be modelled. A crucial challenge for applying the technique is to control the sources. Here, we present data that describe the efficiency of explosive sources in the ice cover. Analysis of the data shows, that the ice cap traps a significant amount of energy, which is observed...... as a strong ice wave. The ice cap leads to low transmission of energy into the crust such that charges need be larger than in conventional onshore experiments to obtain reliable seismic signals. The strong reflection coefficient at the base of the ice generates strong multiples which may mask for secondary...

  18. Dynamic Interaction between Cap & Trade and Electricity Markets

    Science.gov (United States)

    Jeev, Kumar

    Greenhouse Gases (GHG), such as Carbon-Dioxide (CO2), which is released in the atmosphere due to anthropogenic activities like power production, are now accepted as the main culprits for global warming. The Regional Greenhouse Gas Initiative (RGGI), an initiative of the North East and Mid-Atlantic States of the United States (US) for limiting the emission of GHG, has developed a regional cap-and-trade program for CO2 emissions for power plants. Existing cap-and-trade programs in US and Europe for Greenhouse Gases have recently been plagued by over-allocation. Carbon prices recently collapsed in all these markets during the global recession. Since then, there have been significant policy changes, which have resulted in the adoption of aggressive emission cap targets by most major carbon emission markets. This is expected to make carbon emissions availability more restrictive, raising the prices of these credits. These emissions markets are expected to have a major impact on the wholesale electricity markets. Two models to study the interaction of these two markets are presented. These models assess the impact of the emissions market on wholesale electricity prices. The first model characterizes the competition between two types of power plants (coal and gas) in both the electricity and emissions markets as a dynamic game using the Cournot approximation. Under this approximation, we find that in the Nash equilibrium the plants increase their permit allocation to high-demand periods and the marginal value of each credit for a plant is identical in all periods under their optimal equilibrium strategy. The second numerical model allows us to explicitly evaluate the closed loop equilibrium of the dynamic interaction of two competitors in these markets. We find that plants often try to corner the market and push prices all the way to the price cap. Power plants derive most of their profits from these extreme price regimes. In the experiments where trading is allowed

  19. Martian north polar cap summer water cycle

    Science.gov (United States)

    Brown, Adrian J.; Calvin, Wendy M.; Becerra, Patricio; Byrne, Shane

    2016-10-01

    A key outstanding question in Martian science is "are the polar caps gaining or losing mass and what are the implications for past, current and future climate?" To address this question, we use observations from the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) of the north polar cap during late summer for multiple Martian years, to monitor the summertime water cycle in order to place quantitative limits on the amount of water ice deposited and sublimed in late summer. We establish here for the first time the summer cycle of water ice absorption band signatures on the north polar cap. We show that in a key region in the interior of the north polar cap, the absorption band depths grow until Ls = 120, when they begin to shrink, until they are obscured at the end of summer by the north polar hood. This behavior is transferable over the entire north polar cap, where in late summer regions 'flip' from being net sublimating into net condensation mode. This transition or 'mode flip' happens earlier for regions closer to the pole, and later for regions close to the periphery of the cap. The observations and calculations presented herein estimate that on average a water ice layer ∼70 microns thick is deposited during the Ls = 135-164 period. This is far larger than the results of deposition on the south pole during summer, where an average layer 0.6-6 microns deep has been estimated by Brown et al. (2014) Earth Planet. Sci. Lett., 406, 102-109.

  20. Product Platform Modeling

    DEFF Research Database (Denmark)

    Pedersen, Rasmus

    This PhD thesis has the title Product Platform Modelling. The thesis is about product platforms and visual product platform modelling. Product platforms have gained an increasing attention in industry and academia in the past decade. The reasons are many, yet the increasing globalisation...... with two main purposes; First, various phenomena related to product platforms are investigated and secondly it is investigated how some of these phenomena can be visually modelled in order to support decision making in industrial platform projects. The investigation of platform phenomena is based...... effects are obtained without necessarily introducing standardised physical interfaces between the varying elements. By means of three industrial cases, in the companies Danfoss, Grundfos and Aker Solutions, it is discussed and exemplified how some of the phenomena and effects related to reuse...

  1. Pharmacy benefit caps and the chronically ill.

    Science.gov (United States)

    Joyce, Geoffrey F; Goldman, Dana P; Karaca-Mandic, Pinar; Zheng, Yuhui

    2007-01-01

    In this paper we examine medication use among retirees with employer-sponsored drug coverage both with and without annual benefit limits. We find that pharmacy benefit caps are associated with higher rates of medication discontinuation across the most common therapeutic classes and that only a minority of those who discontinue use reinitiate therapy once coverage resumes. Plan members who reach their cap are more likely than others to switch plans and increase their rate of generic use; however, in most cases, the shift is temporary. Given the similarities between these plans and Part D, we make some inferences about reforms for Medicare.

  2. Assembling the CMS yoke end-caps

    CERN Multimedia

    Laurent Guiraud

    2001-01-01

    A crane is used to piece together one of the end-caps that will provide the path for magnetic flux return on the CMS experiment. A total of six end-cap discs will be assembled before being positioned on the barrel yoke to complete the huge 12 500 tonne cylinder yoke. The magnetic field produced will be greater than any other solenoid created to date at 4 T, 100 000 times greater than the Earth's natural magnetic field, and will store enough energy to melt 18 tonnes of gold.

  3. Design and implementation of the CAPS receiver

    Institute of Scientific and Technical Information of China (English)

    HU YongHui; HUA Yu; HOU Lei; WEI JingFa; WU JianFeng

    2009-01-01

    In this paper,baaed on analyses of the Chinese Area Positioning System (CAPS) satellite (GEO satellite) resources and signal properties,the signal power at the port of the receiver antenna is estimated,and the implementation projects are presented for a switching band C to band L CAPS C/A code receiver integrated with GPS receiver suite and for a CAPS dual frequency P code receiver.A microstrip receiving antenna is designed with high sensitivity and wide beam orientation,the RF front end of the C/A code and P code receivers,and a processor is designed for the navigation baseband.A single frequency CAPS C/A code receiver and a CAPS dual frequency P code receiver are built at the same time.A software process flow is provided,and research on relatively key techniques is also conducted,such as signal searching,code loop and carrier loop algorithms,a height assistant algorithm,a dual frequency difference speed measurement technique,a speed measurement technique using a single frequency source with frequency assistance,and a CAPS time correcting algorithm,according to the design frame of the receiver hardware.Research results show that the static plane positioning accuracy of the CAPS C/A code receiver is 20.5-24.6 m,height accuracy is 1.2-12.8 m,speed measurement accuracy is 0.13-0.3 m/s,dynamic plane positioning accuracy is 24.4 m,height accuracy is 3.0 m,and speed measurement accuracy is 0.24 m/s.In the case of C/A code,the timing accuracy is 200 ha,and it is also shown that the positioning accuracy of the CAPS precise code receiver (1σ) is 5 m from south to north,and 0.8 m from east to west.Finally,research on positioning accuracy is also conducted.

  4. Towards a Market Entry Framework for Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2016-01-01

    This study presents a framework to understand and explain the design and configuration of digital payment platforms and how these platforms create conditions for market entries. By embracing the theoretical lens of platform envelopment, we employed a multiple and comparative-case study...... in a European setting by using our framework as an analytical lens to assess market-entry conditions. We found that digital payment platforms have acquired market entry capabilities, which is achieved through strategic platform design (i.e., platform development and service distribution) and technology design...... (i.e., issuing evolutionary and revolutionary payment instruments). The studied cases reveal that digital platforms leverage payment services as a mean to bridge and converge core and adjacent platform markets. In so doing, platform envelopment strengthens firms’ market position in their respective...

  5. User definition and mission requirements for unmanned airborne platforms, revised

    Science.gov (United States)

    Kuhner, M. B.; Mcdowell, J. R.

    1979-01-01

    The airborne measurement requirements of the scientific and applications experiment user community were assessed with respect to the suitability of proposed strawman airborne platforms. These platforms provide a spectrum of measurement capabilities supporting associated mission tradeoffs such as payload weight, operating altitude, range, duration, flight profile control, deployment flexibility, quick response, and recoverability. The results of the survey are used to examine whether the development of platforms is warranted and to determine platform system requirements as well as research and technology needs.

  6. Assessment of DICOM Viewers Capable of Loading Patient-specific 3D Models Obtained by Different Segmentation Platforms in the Operating Room.

    Science.gov (United States)

    Lo Presti, Giuseppe; Carbone, Marina; Ciriaci, Damiano; Aramini, Daniele; Ferrari, Mauro; Ferrari, Vincenzo

    2015-10-01

    Patient-specific 3D models obtained by the segmentation of volumetric diagnostic images play an increasingly important role in surgical planning. Surgeons use the virtual models reconstructed through segmentation to plan challenging surgeries. Many solutions exist for the different anatomical districts and surgical interventions. The possibility to bring the 3D virtual reconstructions with native radiological images in the operating room is essential for fostering the use of intraoperative planning. To the best of our knowledge, current DICOM viewers are not able to simultaneously connect to the picture archiving and communication system (PACS) and import 3D models generated by external platforms to allow a straight integration in the operating room. A total of 26 DICOM viewers were evaluated: 22 open source and four commercial. Two DICOM viewers can connect to PACS and import segmentations achieved by other applications: Synapse 3D® by Fujifilm and OsiriX by University of Geneva. We developed a software network that converts diffuse visual tool kit (VTK) format 3D model segmentations, obtained by any software platform, to a DICOM format that can be displayed using OsiriX or Synapse 3D. Both OsiriX and Synapse 3D were suitable for our purposes and had comparable performance. Although Synapse 3D loads native images and segmentations faster, the main benefits of OsiriX are its user-friendly loading of elaborated images and it being both free of charge and open source. PMID:25739346

  7. Noise Occupational Hygiene Assessment of Platform Offshore%某海洋石油平台噪声职业病危害卫生学评价

    Institute of Scientific and Technical Information of China (English)

    宋文青; 邵华; 赵倩

    2011-01-01

    目的 引入结构性声传播噪声影响分析,对某海洋石油作业平台噪声职业病危害进行卫生学评价.方法 对某石油作业平台噪声职业病危害场所及防护措施进行卫生学调查,检测分析噪声强度评价其危害.结果 发电机间噪声检测超标,噪声危害达到Ⅱ级,其他场所均符合卫生学要求.结论 发电机间在做好监测的同时,应加强管理、个体防护等措施,控制噪声危害.%[Objective]To introduce structural sound transmission noise analysis for hygienically evaluation of noise hazards in a offshore oil platform.[Methods]Hygienically evaluation was performed on the workplace with noise hazards and the protective measures in a offshore oil platform.The noise intensity was tested for harm evaluation.[Results]Noise intensity in power room was over standard and up to the hazard grade H, other places met the hygiene requirements.[Conclusion]Generator room should be monitored continually.Administration, personal protection and other means should be strengthened to control noise hazardous.

  8. Long-Term Outdoor Reliability Assessment of a Wireless Unit for Air-Quality Monitoring Based on Nanostructured Films Integrated on Micromachined Platforms

    Directory of Open Access Journals (Sweden)

    Massimiliano Decarli

    2012-06-01

    Full Text Available We have fabricated and tested in long-term field operating conditions a wireless unit for outdoor air quality monitoring. The unit is equipped with two multiparametric sensors, one miniaturized thermo-hygrometer, front-end analogical and digital electronics, and an IEEE 802.15.4 based module for wireless data transmission. Micromachined platforms were functionalized with nanoporous metal-oxides to obtain multiparametric sensors, hosting gas-sensitive, anemometric and temperature transducers. Nanoporous metal-oxide layer was directly deposited on gas sensing regions of micromachined platform batches by hard-mask patterned supersonic cluster beam deposition. An outdoor, roadside experiment was arranged in downtown Milan (Italy, where one wireless sensing unit was continuously operated side by side with standard gas chromatographic instrumentation for air quality measurements. By means of a router PC, data from sensing unit and other instrumentation were collected, merged, and sent to a remote data storage server, through an UMTS device. The whole-system robustness as well as sensor dataset characteristics were continuously characterized over a run-time period of 18 months.

  9. CAP Reform and the Doha Development Agenda

    NARCIS (Netherlands)

    van Dijck, P.; Faber, G.

    2004-01-01

    The CAP reforms that the EU accepted in June 2003 will partially decouple direct income payments to farmers from production and make these payments conditional on cross-compliance. The reforms are driven by enlargement of EU membership, budgetary constraints, mounting pressures from diverse animal w

  10. The Effectiveness of Caps on Political Lobbying

    NARCIS (Netherlands)

    Matejka, M.; Onderstal, A.M.; De Waegenaere, A.M.B.

    2002-01-01

    In this paper, we analyze a lobby game, modelled as an all-pay auction in which interest groups submit bids in order to obtain a political prize.The bids are restricted to be below a cap imposed by the government.For both an incomplete and a complete information setting we show the following results

  11. INTERNATIONAL WHEAT PRICE TRANSMISSION AND CAP REFORM

    OpenAIRE

    Thompson, Stanley R.; Bohl, Martin T.

    1999-01-01

    We illustrate how CAP policy reforms influence the transmission of world prices to domestic markets. Monthly wheat price data in Germany are used to obtain price transmission elasticities. Correctly accounting for structural breaks and the time series properties of the data yield transmission elasticities that differ dramatically among policy regimes.

  12. Successful treatment of cap polyposis with infliximab.

    Science.gov (United States)

    Bookman, Ian D; Redston, Mark S; Greenberg, Gordon R

    2004-06-01

    Cap polyposis is a disorder characterized by bloody diarrhea with rectosigmoid polyps covered by a cap of fibropurulent exudate. The pathogenesis is unknown, but histological features suggest that mucosal prolapse may play a role. Drug therapies are usually unsuccessful, and treatment requires sigmoid resection or, if the disease recurs after initial surgical resection, panproctocolectomy. We report the case of a 36-year-old woman with characteristic clinical, endoscopic, and histological features of cap polyposis. Investigations included normal anorectal manometry and defecography, without evidence of prolapse. The patient's disease was unresponsive to treatment with mesalamine, antibiotics, lidocaine enemas, and corticosteroids. One infusion of infliximab 5 mg/kg provided dramatic symptomatic improvement but minimal endoscopic or histological change. After 4 infliximab infusions at 8-week intervals, endoscopy of the rectum and sigmoid colon was normal, and biopsies showed complete histological resolution of the inflammatory process. Well-being with normal endoscopy and histology has been maintained at 38 months, without further treatment. It was concluded that infliximab is effective therapy for cap polyposis and avoids the requirement for surgery. No clinical evidence was obtained to support mucosal prolapse as a causative factor, but the response to infliximab suggests a role for tumor necrosis factor-alpha in the pathogenesis of this disorder. PMID:15188181

  13. Knowledge Management at Cap Gemini Nederland

    NARCIS (Netherlands)

    M.J. Vlaanderen (Marie Jose)

    1998-01-01

    textabstractThe theme of this paper is knowledge management (KM) at an organization that provides information technology (IT) services. It is based on the results of a KM-survey of the Finance Division of Cap Gemini (CG) conducted during the spring of 1997.

  14. ATLAS: End-cap Toroid assembly

    CERN Multimedia

    2006-01-01

    In building 191 and building 180- assembly of this massive piece.To reach the top of the end-cap the cranes has to be used and during the assembly you can see welding and hear many tools running background.

  15. ALTERNATE REDUCTANT COLD CAP EVALUATION FURNACE PHASE II TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F.; Stone, M.; Miller, D.

    2014-09-03

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further research and development of this flowsheet eliminated the formic acid, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric-glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP):  Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the CEF cold cap and vapor space data to the benchmark melter flammability models;  Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: o Define new cold cap reactions and global kinetic parameters in support of the melter flammability model development; o Quantify off-gas surging potential of the feed; o Characterize off-gas condensate for complete organic and inorganic carbon species. After charging the CEF with cullet from Phase I CEF testing, the melter was slurry-fed with glycolic flowsheet based SB6-Frit 418 melter feed at 36

  16. Interconnection of Communities of Practice: A Web Platform for Knowledge Management

    CERN Document Server

    Garrot-Lavoué, Elise

    2012-01-01

    Our works aim at developing a Web platform to connect various Communities of Practice (CoPs) and to capitalise on all their knowledge. This platform addresses CoPs interested in a same general activity, for example tutoring. For that purpose, we propose a general model of Interconnection of Communities of Practice (ICP), based on the concept of Constellation of Practice (CCP) developed by Wenger (1998). The model of ICP was implemented and has been used to develop the TE-Cap 2 platform which has, as its field of application, educational tutoring activities. In particular, we propose an indexation and search tool for the ICP knowledge base. The TE-Cap 2 platform has been used in real conditions. We present the main results of this descriptive investigation to validate this work.

  17. Continuous Platform Development

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil

    , but continuous product family evolution challenges this strategy. The concept of continuous platform development is based on the fact that platform development should not be a one-time experience but rather an ongoing process of developing new platforms and updating existing ones, so that product family...... low risks and investments but also with relatively fuzzy results. When looking for new platform projects, it is important to make sure that the company and market is ready for the introduction of platforms, and to make sure that people from marketing and sales, product development, and downstream......, while Grundfos is relatively new within this area. This study puts emphasis on platform projects and defines such projects as something very different from product development projects and more similar to industrial research projects, due to the fact that they are continuous activities with relatively...

  18. Platform Competition in Telecommunications

    OpenAIRE

    Church, Jeffrey; Gandal, Neil

    2004-01-01

    In this Paper we consider the economics of platform competition in telecommunications. Platform competition occurs when different, sometimes incompatible, technologies compete to provide telecommunications services to end-users. Battles between competing technologies have been an important feature of telecommunications in the last twenty or so years. Examples of platform competition in telecommunications include wireless vs. wireline networks, competing wireless options, such as satellite vs....

  19. Constructing HSOC data platform

    International Nuclear Information System (INIS)

    HXMT is the only independent space astronomic secondary planet during 2006-2010 in China. Also it is the first independent astronomic secondary planet of China. HSOC, which is the data management sub-system, is the fundamental infrastructure of HXMT's scientific administration center. The data platform is the object of data management sub-system, which is an integrated platform supporting storage, share, exchange, query, statistics and management of data. The paper introduces the meaning and construction of HSOC data platform. (authors)

  20. Eclipse Platform Technical Overview

    OpenAIRE

    ALS-NSCORT,

    2003-01-01

    The Eclipse Platform is designed for building integrated development environments (IDEs) that can be used to create applications as diverse as web sites, embedded JavaTM programs, C++ programs, and Enterprise JavaBeansTM. This paper is a general technical introduction to the Eclipse Platform. Part I presents a technical overview of its architecture. Part II is a case study of how the Eclipse Platform was used to build a full-featured Java development environment. 20 pages Provider Notes...

  1. The Creative Platform

    DEFF Research Database (Denmark)

    Byrge, Christian; Hansen, Søren

    This book is about introducing more creativity into general educational courses and cross-disciplinary activities. It is directed toward teachers at all levels in the educational system, but the Creative Platform is a general model, and thus the creative process will fundamentally be the same...... you can use in your work with the Creative Platform. This book is intended as an introduction on how to use the Creative Platform....

  2. Games and Platform Decisions

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    be described as being a configuration problem with a high number of variables. These variables are different in nature; they have contradictory influence on the total performance, and, their importance change over time. Consequently, the specific platform decisions become highly complex and the consequences...... support to the platform decision making.......Platform is an ambiguous multidisciplinary concept. The philosophy behind it is easy to communicate and makes intuitively sense. However, the ease in communication does overshadow the high complexity when the concept is implemented. The practical industrial platform implementation challenge can...

  3. Cross-Platform Assessment of Genomic Imbalance Confirms the Clinical Relevance of Genomic Complexity and Reveals Loci with Potential Pathogenic Roles in Diffuse Large B-Cell Lymphoma

    Science.gov (United States)

    Dias, Lizalynn M.; Thodima, Venkata; Friedman, Julia; Ma, Charles; Guttapalli, Asha; Mendiratta, Geetu; Siddiqi, Imran N.; Syrbu, Sergei; Chaganti, R. S. K.; Houldsworth, Jane

    2016-01-01

    Genomic copy number alterations (CNAs) in diffuse large B-cell lymphoma (DLBCL) have roles in disease pathogenesis but overall clinical relevance remains unclear. Herein, an unbiased algorithm was uniformly applied across three genome profiling datasets comprising 392 newly-diagnosed DLBCL specimens that defined 32 overlapping CNAs, involving 36 minimal common regions (MCRs). Scoring criteria were established for 50 aberrations within the MCRs while considering peak gains/losses. Application of these criteria to independent datasets revealed novel candidate genes with coordinated expression, such as CNOT2, potentially with pathogenic roles. No one single aberration significantly associated with patient outcome across datasets, but genomic complexity, defined by imbalance in more than one MCR, significantly portended adverse outcome in two of three independent datasets. Thus, the standardized scoring of CNAs currently developed can be uniformly applied across platforms, affording robust validation of genomic imbalance and complexity in DLBCL and overall clinical utility as biomarkers of patient outcome. PMID:26294112

  4. Facially amphiphilic thiol capped gold and silver nanoparticles

    OpenAIRE

    Bhat, Shreedhar; Maitra, Uday

    2008-01-01

    A series of bile acid-derived facially amphiphilic thiols have been used to cap sliver and gold nanoparticles. The self-assembling properties of these steroid-capped nanoparticles have been investigated and reported in this article.

  5. Facially amphiphilic thiol capped gold and silver nanoparticles

    Indian Academy of Sciences (India)

    Shreedhar Bhata; Uday Maitra

    2008-11-01

    A series of bile acid-derived facially amphiphilic thiols have been used to cap sliver and gold nanoparticles. The self-assembling properties of these steroid-capped nanoparticles have been investigated and reported in this article.

  6. EFFECTIVENESS OF CLAY POLYMER CAPPING MATERIAL IN ISOLATING ORGANIC AND INORGANIC SEDIMENT CONTAMINATION

    Science.gov (United States)

    The United States Environmental Protection Agency (U.S. EPA) National Risk Management Research Laboratory (NRMRL) has been funding the demonstration of sediment capping remediation design and assessment in the Anacostia River in Washington, D.C., through the Superfund Innovative ...

  7. How the House of Morgan Cooperated to Develop the Large-Cap US Multinational Corporation, 1895-1913

    OpenAIRE

    Sawe, Joseph

    2015-01-01

    The following investigation is intended to determine how the large-cap US multinational corporation was further advanced during the pivotal years of 1895-1913 by a leading private unincorporated institution—House of Morgan. Historical review and assessment focused on the broader US society, government, monetary landscape, the House of Morgan, leading large cap US multinationals; looking at both the key organizations and underlying people in power. The report framework focuses upon the develop...

  8. Exploring plasmonic coupling in hole-cap arrays

    OpenAIRE

    Schmidt, Thomas M.; Maj Frederiksen; Vladimir Bochenkov; Sutherland, Duncan S

    2015-01-01

    The plasmonic coupling between gold caps and holes in thin films was investigated experimentally and through finite-difference time-domain (FDTD) calculations. Sparse colloidal lithography combined with a novel thermal treatment was used to control the vertical spacing between caps and hole arrays and compared to separated arrays of holes or caps. Optical spectroscopy and FDTD simulations reveal strong coupling between the gold caps and both Bloch Wave-surface plasmon polariton (BW-SPP) modes...

  9. Imaging and analysis of microcalcifications and lipid/necrotic core calcification in fibrous cap atheroma.

    Science.gov (United States)

    Maldonado, Natalia; Kelly-Arnold, Adreanne; Laudier, Damien; Weinbaum, Sheldon; Cardoso, Luis

    2015-06-01

    The presence of microcalcifications (µCalcs) >5 µm within the cap of human fibroatheroma has been shown to produce a 200-700% increase in peak circumferential stress, which can transform a stable plaque into a vulnerable one, whereas µCalcs 5 µm based on the gross morphological features of fibroatheromas, and the correlation between the size and distribution of µCalcs in the cap and the calcification in the lipid/necrotic core beneath it. Atherosclerotic lesions (N = 72) were imaged using HR-μCT at 2.1-μm resolution for detailed analysis of atheroma morphology and composition, and validated using non-decalcified histology. At 2.1-μm resolution one observes four different patterns of calcification within the lipid/necrotic core, and is able to elucidate the 3D spatial progression of the calcification process using these four patterns. Of the gross morphological features identified, only minimum cap thickness positively correlated with the existence of µCalcs > 5 µm in the cap. We also show that µCalcs in the cap accumulate in the vicinity of the lipid/necrotic core boundary with few on the lumen side of the cap. HR-μCT enables three-dimensional assessment of soft tissue composition, lipid content, calcification patterns within lipid/necrotic cores and analysis of the axial progression of calcification within individual atheroma. The distribution of µCalcs within the cap is highly non-uniform and decreases sharply as one proceeds from the lipid pool/necrotic core boundary to the lumen. PMID:25837377

  10. Mass changes in Arctic ice caps and glaciers: implications of regionalizing elevation changes

    DEFF Research Database (Denmark)

    Nilsson, Johan; Sørensen, Louise Sandberg; Barletta, Valentina Roberta;

    2015-01-01

    The mass balance of glaciers and ice caps is sensitive to changing climate conditions. The mass changes derived n this study are determined from elevation changes derived measured by the Ice, Cloud, and land Elevation Satellite (ICESat) for the time period 2003–2009. Four methods, based...... of the regional mass balance of Arctic ice caps and glaciers to different regionalization schemes. The sensitivity analysis is based on studying the spread of mass changes and their associated errors, and the suitability of the different regionalization techniques is assessed through cross validation.The cross...

  11. Modeling bubbly-cap flows using two-group average bubble number density

    International Nuclear Information System (INIS)

    The basic concept of two-group average bubble number density equations along with three-fluid model has been demonstrated for vertical gas-liquid flow. Specifically, the current study focused on: (i)classification of bubble interaction between spherical bubbles (Group-1) and cap bubbles (Group- 2), (ii) preliminary consideration of source and sink terms in the averaged bubble number density equations via the model of Hibiki and Ishii [1] and (iii) assessment by means of experimental data sets at bubbly-to-cap flow transition. Reasonable agreement was achieved between measured and predicted distributions of void fraction, interfacial area concentration (IAC) and volume equivalent bubble diameter. (author)

  12. CMS end-cap yoke at the detector's assembly site.

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The magnetic flux generated by the superconducting coil in the CMS detector is returned via an iron yoke comprising three end-cap discs at each end (end-cap yoke) and five concentric cylinders (barrel yoke). This picture shows the first of three end-cap discs (red) seen through the outer cylinder of the vacuum tank which will house the superconducting coil.

  13. EURESCOM Services Platform

    NARCIS (Netherlands)

    Nieuwenhuis, Lambert J.M.; Halteren, van Aart

    1999-01-01

    This paper presents the results of the EURESCOM Project 715. In February 1999, a large team of researchers from six European public network operators completed a two year period of cooperative experiments on a TINA-based environment, called the EURESCOM Services Platform (ESP). This platform consist

  14. Climate News Across Media Platforms

    DEFF Research Database (Denmark)

    Eskjær, Mikkel Fugl

    2015-01-01

    In a changing media landscape marked by technological, institutional and cultural convergence, comparative and cross-media content analysis represents a valuable analytical tool in mapping the diverse channels of climate change communication. This paper presents a comparative study of climate...... change news on five different media platforms: newspapers, television, radio, web-news and mobile news. It investigates the themes and actors represented in public climate change communication as well as the diverse possibilities of participating in public debates and information sharing. By combining...... quantitative and qualitative content analysis the paper documents and explores the extent and character of climate change news across different media platforms. The study aims at contributing to the on-going assessment of how news media are addressing climate change at a time when old and new media...

  15. Product Platform Replacements

    DEFF Research Database (Denmark)

    Sköld, Martin; Karlsson, Christer

    2012-01-01

    shed light on this unexplored and growing managerial concern, the purpose of this explorative study is to identify operational challenges to management when product platforms are replaced. Design/methodology/approach – The study uses a longitudinal field-study approach. Two companies, Gamma and Omega......Purpose – It is argued in this article that too little is known about product platforms and how to deal with them from a manager's point of view. Specifically, little information exists regarding when old established platforms are replaced by new generations in R&D and production environments. To...... distinguishing between platform replacement “height” and “width”. Seven groups of managerial measures for dealing with the issues are recommended. Originality/value – The study aims to contribute to the existing literature by taking a managers' perspective of product platform development. Its specific...

  16. A critical evaluation of social impact assessment methodologies and a call to measure economic and social impact holistically through the External Rate of Return platform

    OpenAIRE

    Florman, Mark; Vidra, Robyn Klingler; Facada, Martim Jacinto

    2016-01-01

    Companies, investors, international organisations and non-governmental organisations have designed frameworks and tools for measuring the social impact of business. In this report we evaluate the landscape of existing social impact assessment methods. We first delineate the characteristics, context and development of leading methodologies. We then critically evaluate the strengths and weaknesses of today’s leading social impact assessment methodologies. We identify the strengths of existing a...

  17. NetCAP status report for the end of fiscal year 2010.

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, Benjamin Roger; Young, Christopher John

    2010-10-01

    Fiscal year 2010 (FY10) is the second full year of NetCAP development and the first full year devoted largely to new feature development rather than the reimplementation of existing capabilities found in NetSim (Sereno et al., 1990). Major tasks completed this year include: (1) Addition of hydroacoustic simulation; (2) Addition of event Identification simulation; and (3) Initial design and preparation for infrasound simulation. The Network Capability Assessment Program (NetCAP) is a software tool under development at Sandia National Laboratories used for studying the capabilities of nuclear explosion monitoring networks. This report discusses motivation and objectives for the NetCAP project, lists work performed prior to fiscal year 2010 (FY10) and describes FY10 accomplishments in detail.

  18. Greening CAP payments: a missed opportunity?

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Alan

    2013-01-15

    At an important point in the current reform of the Common Agricultural Policy (CAP), a new IIEA policy brief by Professor Alan Matthews, one of the EU’s foremost experts on the topic, considers proposals to green direct farm payments. Professor Matthews argues that proposed greening of direct payments – the key innovation in the current round of CAP Reform – look likely to fail. While greening may survive as a concept, the likely outcome of the negotiations between Agriculture Ministers and the European Parliament will deliver little practical environmental benefit. The paper examines the rationale underpinning greening, arguing that it exists to justify the continuation of a large agricultural budget, explores reasons for the apparent failure of the proposals, and reflects on the implications for future efforts to better integrate environmental objectives into EU agriculture policy. This is the first in a series of Environment Nexus policy briefs by leading experts in the fields of agriculture, energy, climate change and water.

  19. Should we geoengineer larger ice caps?

    CERN Document Server

    Haqq-Misra, Jacob

    2015-01-01

    The climate of Earth is susceptible to catastrophes that could threaten the longevity of human civilization. Geoengineering to reduce incoming solar radiation has been suggested as a way to mediate the warming effects of contemporary climate change, but a geoengineering program for thousands of years could also be used to enlarge the size of the polar ice caps and create a permanently cooler climate. Such a large ice cap state would make Earth less susceptible to climate threats and could allow human civilization to survive further into the future than otherwise possible. Intentionally extending Earth's glacial coverage will require uninterrupted commitment to this program for millenia but would ultimately reach a cooler equilibrium state where geoengineering is no longer needed. Whether or not this program is ever attempted, this concept illustrates the need to identify preference among potential climate states to ensure the long-term success of civilization.

  20. Status of the AlCap experiment

    CERN Document Server

    Litchfield, R Phillip

    2015-01-01

    The AlCap experiment is a joint project between the COMET and Mu2e collaborations. Both experiments intend to look for the lepton-flavour violating conversion $\\mu + A \\rightarrow e + A$, using tertiary muons from high-power pulsed proton beams. In these experiments the products of ordinary muon capture in the muon stopping target are an important concern, both in terms of hit rates in tracking detectors and radiation damage to equipment. The goal of the AlCap experiment is to provide precision measurements of the products of nuclear capture on Aluminium, which is the favoured target material for both COMET and Mu2e. The results will be used for optimising the design of both conversion experiments, and as input to their simulations. Data was taken in December 2013 and is currently being analysed.

  1. Assessment of postpartum rehabilitation using Glazer assessment scheme with biofeedback therapy instrument as platform%以生物反馈治疗仪为平台的Glazer法评估产后康复情况

    Institute of Scientific and Technical Information of China (English)

    罗伟; 任艳蕊; 易绍媛; 刘锋

    2015-01-01

    目的:采用Glazer评估的生物反馈治疗仪诊断产妇产后盆底肌肉受损的程度,进而科学地指导医生通过电刺激和生物反馈对患者实施精准地康复治疗.方法:选取2011年6月~2013年6月该院妇产科收治的产妇897例,分为观察组(450例)和对照组(447例),对所有研究对象进行压力检测.观察组进行电刺激和生物反馈治疗,对照组给予常规盆底肌功能锻炼.采用MyoTrac infiniti公司的SA9800型生物反馈治疗仪对Ⅰ、Ⅱ型肌纤维功能进行评估.治疗3个月后比较两组产妇的盆底肌张力、阴道肌电压以及尿失禁发生率.结果:观察组产妇阴道肌电压情况显著改善、盆底肌力强度增加、产妇尿失禁发生率显著降低、尿失禁症状明显改善,与对照组比较,差异有统计学意义(P<0.05).结论:采用SA9800型生物反馈治疗仪配合Glazer评估诊断可对患者治疗起到指导作用.在Glazer评估的标准下,可以量化测定盆底肌力和盆底肌肉受损的程度.经过正确康复治疗,可以帮助产妇提高盆底肌张力,降低尿失禁发生率,有效减少产后常见疾病的发生率.%Objective:To diagnose the degree of postpartum pelvic floor muscle damage using Glazer assessment scheme with biofeedback therapy instrument as platform,scientifically guide physicians to provide precise rehabilitation therapy through electrical stimulation and biofeedback.Methods:A total of 897 postpartum women treated in Department of Gynecology and Obstetrics in the hospital from June 2011 to June 2013 were selected and divided into observation group (450 women) and control group (447 women),pressure measurement was performed among all the women.The women in observation group were treated with electrical stimulation and biofeedback therapy,while the women in control group were treated with routine pelvic floor muscle function training.SA9800 type biofeedback therapy apparatus (Myo-Trac infiniti Company) was used to

  2. A high-throughput O-glycopeptide discovery platform for seromic profiling

    DEFF Research Database (Denmark)

    Blixt, Ola; Cló, Emiliano; Nudelman, Aaron Samuel;

    2010-01-01

    . Here, we have developed a synthetic screening microarray platform for facile display of O-glycosylated peptides (O-PTMs). By introduction of a capping step during chemical solid-phase glycopeptide synthesis, selective enrichment of N-terminal glycopeptide end products was achieved on an amine...

  3. ATLAS End-cap Part II

    CERN Multimedia

    2007-01-01

    The epic journey of the ATLAS magnets is drawing to an end. On Thursday 12 July, the second end-cap of the ATLAS toroid magnet was lowered into the cavern of the experiment with the same degree of precision as the first (see Bulletin No. 26/2007). This spectacular descent of the 240-tonne component, is one of the last transport to be completed for ATLAS.

  4. Polar cap size metrics study at CCMC

    Science.gov (United States)

    Rastaetter, L.; Kuznetsova, M. M.; Hesse, M.; Gombosi, T. I.; Raeder, J.; Weimer, D.

    2005-12-01

    The Community-Coordinated Modeling Center (CCMC) tests space physics models covering space from the Sun's corona to the Earth's ionosphere and makes them available for researchers through a run-on-request capability. The polar cap size and location as observed by global auroral imagers is used as a basis model to study the performance of global MHD simulation models and statistical models of the auroral ionosphere. With good confidence one can assume that auroral emissions are located within the closed magnetic field lines in a narrow region adjacent to the boundary of the open field line region of the polar cap. In this study we are using imager data from POLAR (FUV) for several events from 1997 to 2000 for which reasonable coverage is available. Simulation runs have been performed using the global magnetospheric models BATSRUS (T. Gombosi et al., U. Michigan) and OpenGGCM (J. Raeder, U. New Hampshire) as well as the Weimer (2000,2005) field-aligned current models (D. Weimer, Mission Research Corp.) fed with upstream solar wind data from the ACE or Geotail satellites. In addition to direct field line tracings available from the 3D MHD model outputs, we use field-aligned currents from both MHD models and the Weimer-2K model to determine the polar cap boundary by using the position of the maximum absolute FAC value in 16 local time sectors. We define skill scores that measure the agreement in the polar cap sizes and location between measurements and models as an example of implementations of metrics to track model performance and apply the analysis to a number of storm event days.

  5. Particle Entrainment in Spherical-Cap Wakes

    OpenAIRE

    Warncke, N.G.W.; Delfos, R.; Ooms, G.; Westerweel, J.

    2011-01-01

    In this work we study the preferential concentration of small particles in the turbulent wake behind a spherical-cap object. We present a model predicting the mean particle concentration in the near-wake as a function of the characteristic Stokes number of the problem, the turbulence level and the Froude number. We compare the model with our experimental results on this flow, measured in a vertical water tunnel.

  6. Translated origin spherical cap harmonic analysis

    OpenAIRE

    De Santis, A.; Istituto Nazionale di Geofisica, Roma, Italy

    1991-01-01

    The method of spherical cap harmonic analysis (SCHA), due to Haines (1985) is appropriate for regional geomagnetic field modelling as it includes the required potential field constraints and, for a given number of model parameters, describes shorter wavelength features than a global spherical harmonic model. If the origin of the coordinate system is moved from the centre of the Earth towards the surface then the Earth's surface is no longer equidistant from the origin. At the Earth's surface ...

  7. Immunity conferred by an experimental vaccine based on the recombinant PCV2 Cap protein expressed in Trichoplusia ni-larvae.

    Science.gov (United States)

    Pérez-Martín, Eva; Gómez-Sebastián, Silvia; Argilaguet, Jordi M; Sibila, Marina; Fort, María; Nofrarías, Miquel; Kurtz, Sherry; Escribano, José M; Segalés, Joaquim; Rodríguez, Fernando

    2010-03-01

    Porcine circovirus type 2 (PCV2) vaccination has been recently included as a measure to control postweaning multisystemic wasting syndrome (PMWS) in the field. Aiming to obtain a more affordable vaccine to be extensively implemented in the field, a highly efficient non-fermentative expression platform based on Trichoplusia ni (T. ni) larvae was used to produce a baculovirus-derived recombinant PCV2 Cap protein (rCap) for vaccine purposes. Vaccination of pigs with rCap induced solid protection against PCV2 experimental infection, inhibiting both the viremia and the viral shedding very efficiently. The protection afforded by the rCap vaccine strongly correlated with the induction of specific humoral immune responses, even in the presence of PCV2-specific maternal immunity, although cellular responses also seemed to play a partial role. In summary, we have shown that rCap expressed in T. ni larvae could be a cost-effective PCV2 vaccine candidate to be tested under field conditions. PMID:20056179

  8. Pulp-Capping with Mineral Trioxide Aggregate

    Directory of Open Access Journals (Sweden)

    Peycheva Kalina

    2015-11-01

    Full Text Available There are two considerations for direct pulp capping - accidental mechanical pulp exposure and exposure caused by caries. Mineral trioxide aggregate (MTA was used as pulp-capping material to preserve the vitality of the pulpal tissues. Follow-up examinations revealed that treatment was successful in preserving pulpal vitality and continued development of the tooth. On the basis of available information, it appears that MTA is the material of choice for some clinical applications. Material and methods: Cases 18 - 8 teeth with grey MTA, 10 teeth with white MTA; diagnose: Pulpitis chronica ulcerosa, Electro pulpal test (EOD - 30-35 μA, pre-clinical X-ray - without changes in the structures, follow ups for 4 years. Successful treatments: without clinical symptoms and changes in the X-rays: 5 teeth with grey MTA, 8 teeth with white MTA for period of 4 years. Unsuccessful treatments: Clinical symptoms and sometimes changes in the X-ray: 3 with grey MTA, 2 with white MTA. MTA is an appropriate material for pulp-capping and follow-up examinations revealed that the treatment was successful in preserving pulpal vitality.

  9. Reconstructing the Avalon continent: Marginal to inner platform transition in the Cambrian of southern New Brunswick

    Science.gov (United States)

    Landing, E.

    1996-01-01

    A west to east, marginal to inner Avalonian platform transition, comparable to that in southeast Newfoundland and southern Britain, is present in the Cambrian of southern New Brunswick. The Saint John - Caton's Island - Hanford Brook area lay on the marginal platform, and its thick, uppermost Precambrian - lower Lower Cambrian is unconformably overlain by trilobite-bearing, upper Lower Cambrian. An inner platform remnant is preserved in the Cradle Brook outlier 60 km northeast of Saint John. In contrast to the marginal platform sequences, the Cradle Brook outlier has a very thin lower Lower Cambrian and has middle Lower Cambrian strata (Bonavista Group) not present on the marginal platform. The Cradle Brook Lower Cambrian closely resembles inner platform successions in eastern Massachusetts and Trinity and Placentia bays, southeast Newfoundland. A limestone with Camenella baltica Zone fossils on Cradle Brook seems to be the peritidal limestone cap of the subtrilobitic Lower Cambrian known in Avalonian North America (Fosters Point Formation) and England (Home Farm Member).

  10. ALTERNATE REDUCTANT COLD CAP EVALUATION FURNACE PHASE I TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F.; Miller, D.; Zamecnik, J.; Lambert, D.

    2014-04-22

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further evaluation of this flowsheet eliminated the formic acid1, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP):  Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the Cold Cap Evaluation Furnace (CEF) cold cap and vapor space data to the benchmark melter flammability models  Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: o Define new cold cap reactions and global kinetic parameters for the melter flammability models o Quantify off-gas surging potential of the feed o Characterize off-gas condensate for complete organic and inorganic carbon species Prior to startup, a number of improvements and modifications were made to the CEF, including addition of cameras, vessel support temperature measurement, and a

  11. ALTERNATE REDUCTANT COLD CAP EVALUATION FURNACE PHASE I TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F.; Miller, D.; Zamecnik, J.; Lambert, D.

    2014-04-22

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further evaluation of this flowsheet eliminated the formic acid1, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP): Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the Cold Cap Evaluation Furnace (CEF) cold cap and vapor space data to the benchmark melter flammability models Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: o Define new cold cap reactions and global kinetic parameters for the melter flammability models o Quantify off-gas surging potential of the feed o Characterize off-gas condensate for complete organic and inorganic carbon species Prior to startup, a number of improvements and modifications were made to the CEF, including addition of cameras, vessel support temperature measurement, and a heating

  12. What Lies Below a Martian Ice Cap

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image for larger annotated version This image (top) taken by the Shallow Radar instrument on NASA's Mars Reconnaissance Orbiter reveals the layers of ice, sand and dust that make up the north polar ice cap on Mars. It is the most detailed look to date at the insides of this ice cap. The colored map below the radar picture shows the topography of the corresponding Martian terrain (red and white represent higher ground, and green and yellow lower). The radar image reveals four never-before-seen thick layers of ice and dust separated by layers of nearly pure ice. According to scientists, these thick ice-free layers represent approximately one-million-year-long cycles of climate change on Mars caused by variations in the planet's tilted axis and its eccentric orbit around the sun. Adding up the entire stack of ice gives an estimated age for the north polar ice cap of about 4 million years a finding that agrees with previous theoretical estimates. The ice cap is about 2 kilometers (1.2 miles) thick. The radar picture also shows that the boundary between the ice layers and the surface of Mars underneath is relatively flat (bottom white line on the right). This implies that the surface of Mars is not sagging, or bending, under the weight of the ice cap and this, in turn, suggests that the planet's lithosphere, a combination of the crust and the strong parts of the upper mantle, is thicker than previously thought. A thicker lithosphere on Mars means that temperatures increase more gradually with depth toward the interior. Temperatures warm enough for water to be liquid are therefore deeper than previously thought. Likewise, if liquid water does exist in aquifers below the surface of Mars, and if there are any organisms living in that water, they would have to be located deeper in the planet. The topography data are from Mars Orbiter Laser Altimeter, which was flown on NASA's Mars Global Surveyor mission. NPLD stands

  13. An accuracy assessment of the CALIOP/CALIPSO version 2 aerosol extinction product based on a detailed multi-sensor, multi-platform case study

    Directory of Open Access Journals (Sweden)

    M. Kacenelenbogen

    2010-11-01

    Full Text Available The Cloud Aerosol LIdar with Orthogonal Polarization (CALIOP, on board the CALIPSO platform, has measured profiles of total attenuated backscatter coefficient (level 1 products since June 2006. CALIOP's level 2 products, such as the aerosol backscatter and extinction coefficient profiles, are retrieved using a complex succession of automated algorithms. The goal of this study is to help identify potential shortcomings in the CALIOP version 2 level 2 aerosol extinction product and to illustrate some of the motivation for the changes that will be introduced in the next version of CALIOP data (version 3, currently being processed. As a first step, we compared CALIOP version 2-derived AOD with the collocated MODerate Imaging Spectroradiometer (MODIS AOD retrievals over the Continental United States. The best statistical agreement between those two quantities was found over the Eastern part of the United States with, nonetheless, a weak correlation (R ~0.4 and an apparent CALIOP version 2 underestimation (by ~66% of MODIS AOD. To help quantify the potential factors contributing to the uncertainty of the CALIOP aerosol extinction retrieval, we then focused on a one-day, multi-instrument, multiplatform comparison study during the CALIPSO and Twilight Zone (CATZ validation campaign on August 04, 2007. This case study illustrates the following potential reasons for a bias in the CALIOP AOD: (i CALIOP's low signal-to-noise ratio (SNR leading to the misclassification and/or lack of aerosol layer identification, especially close to the Earth's surface; (ii the cloud contamination of CALIOP version 2 aerosol backscatter and extinction profiles; (iii potentially erroneous assumptions of the backscatter-to-extinction ratio (Sa used in CALIOP's extinction retrievals; and (iv calibration coefficient biases in the CALIOP daytime attenuated backscatter coefficient profiles.

  14. Greenhouse gas emissions through cap barriers of landfills

    Energy Technology Data Exchange (ETDEWEB)

    Gourc, J.P.; Staub, M.; Simonin, R. [Grenoble Univ. (France). LTHE

    2009-07-01

    A study was conducted to examine the environmental impacts of landfill cap covers used to produce biogas. The sensitivity of the environmental performance of landfills on biogas collection and recovery systems as well as on cap cover characteristics was investigated. The study examined both soil and geosynthetic landfill cap covers used to maintain impermeability at landfill sites as well as to enable biogas recovery. Two types of cap cover were discussed: (1) a cover that enabled passive wetting of the landfill wastes through rainfall; and (2) an impermeable cap used to control leachate recirculation. The environmental impacts of both caps were discussed. The study showed that landfill cap covers are a significant means of sequestering greenhouse gases (GHGs).

  15. Synthetically and quantitatively assessing gas-sealing ability of volcanic cap rocks in the Xujiaweizi Sag of the Songliao Basin%松辽盆地徐家围子断陷火山岩盖层封气能力综合定量评价

    Institute of Scientific and Technical Information of China (English)

    史集建; 吕延防; 付广; 李丽丽

    2011-01-01

    对松辽盆地徐家围子断陷14个火山岩盖层气藏解剖研究表明,徐家围子断陷白垩系营城组一段顶部火山岩盖层具有高声波时差和井径扩容的特征,岩性主要为凝灰岩、火山角砾岩等,厚度为0~80m,是一套良好的局部盖层.在分析火山岩盖层封气能力的影响因素,即火山岩厚度、排替压力、断层垂向封闭性、天然气黏度和气藏压力基础上,建立了火山岩封气能力综合评价方法,并得到天然气储量丰度与其火山岩盖层封气能力综合评价参数a具有正相关关系.结合天然气储量丰度的划分标准,得到徐家围子断陷形成高储量丰度气藏所需要的a值大于或等于0.005m·Pa·s,形成中等储量丰度气藏所需要的a值为00005~0.002m·Pa·s,形成低储量车度气藏所需要的a值为0.002~0.0003m·Pa·s,形成特低储量丰度气藏所需要的a值小于0.0003m·Pa·s.由此得到火山岩盖层封气能力分布特征:封闭高储量丰度气藏的火山岩盖层主要分布在徐家围子断陷东北部地区;封闭中等储量丰度气藏的火山岩盖层全区基本均有分布;封闭低储量丰度气藏的火山岩盖层主要分布在徐家围子断陷中部和南部地区,西北部也有局部分布;封闭特低储量丰度气藏的火山岩盖层在全区零星分布,主要处于火山岩盖层的尖灭线附近.徐家围子断陷天然气的富集在一定程度上受到火山岩盖层封气能力的控制.%The present paper studied 14 gas reservoirs in the Xujiaweizi rift Sag, Songliao Basin thoroughly and the result showed that volcanic rocks in the top of the first member of Yingcheng Formation, composed mainly of tuff and volcanic breccia with a thickness between 0 and 80 cm, were characterized by high interval transit time and enlarged borehole diameter, and locally formed a suite of good cap rocks.Consequently, a method was established for synthetically assessing gas-sealing ability of these

  16. Ladder attachment platform

    Science.gov (United States)

    Swygert,; Richard, W [Springfield, SC

    2012-08-28

    A ladder attachment platform is provided that includes a base for attachment to a ladder that has first and second side rails and a plurality of rungs that extend between in a lateral direction. Also included is a user platform for having a user stand thereon that is carried by the base. The user platform may be positioned with respect to the ladder so that it is not located between a first plane that extends through the first side rail and is perpendicular to the lateral direction and a second plane that extends through the second side rail and is perpendicular to the lateral direction.

  17. PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment. Recommendations from a joint EPAA - EURL ECVAM ADME workshop.

    NARCIS (Netherlands)

    Bessems, Jos G.; Loizou, George; Krishnan, Kannan; Clewell, Harvey J.; Bernasconi, Camilla; Bois, Frederic; Coecke, Sandra; Collnot, Eva Maria; Diembeck, Walter; Farcal, Lucian Romeo; Geraets, Liesbeth; Gundert-Remy, Ursula; Kramer, Nynke; Küsters, Gabriele; Leite, Sofia B.; Pelkonen, Olavi R.; Schröder, Klaus; Testai, Emanuela; Wilk-Zasadna, Iwona; Zaldívar-Comenges, José Manuel

    2014-01-01

    Information on toxicokinetics is critical for animal-free human risk assessment. Human external exposure must be translated into human tissue doses and compared with in vitro actual cell exposure associated to effects (in vitro-in vivo comparison). Data on absorption, distribution, metabolism and ex

  18. Student Performance and Success Factors in Learning Business Statistics in Online vs. On-Ground Classes Using a Web-Based Assessment Platform

    Science.gov (United States)

    Shotwell, Mary; Apigian, Charles H.

    2015-01-01

    This study aimed to quantify the influence of student attributes, coursework resources, and online assessments on student learning in business statistics. Surveys were administered to students at the completion of both online and on-ground classes, covering student perception and utilization of internal and external academic resources, as well as…

  19. Characterization of cap binding proteins associated with the nucleus

    International Nuclear Information System (INIS)

    Eucaryotic mRNAs a carry 7-methylguanosine triphosphate residue (called cap structure) at their 5' terminus. The cap plays an important role in RNA recognition. Cap binding proteins (CBP) of HeLa cells were identified by photoaffinity labelling using the cap analogue γ-(32P)-(4-(benzoyl-phenyl)methylamido)-7-methylguanosine-5'-triphosphate (BP-m7GTP). Photoreaction of this cap analogue with HeLa cell initiation factors resulted in specific labelling of two polypeptides of Msub(r) 37000 and 26000. The latter was also labelled in crude initiation factors prepared from reticulocytes and is identical to the cap binding protein CBP I previously identified. These cap binding proteins were also affinity labelled in poliovirus infected cell extracts. Photoaffinity reaction with BP-m7GTP of whole HeLa cell homogenate showed three additional polypeptides with Msub(r) 120000, 89000 and 80000. These cap binding proteins were found to be associated with the nucleus and are therefore referred to as nuclear cap binding proteins, i.e. NCBP 1, NCBP 2 and NCBP 3. They were also present in splicing extracts. Photoaffinity labelling in these nuclear extracts was differentially inhibited by various cap analogues and capped mRNAs. Affinity chromatography on immobilized globin mRNA led to a partial separation of the three nuclear cap binding proteins. Chromatography on m7GTP-Sepharose resulted in a specific binding of NCBP 3. The different behaviour of the cap binding proteins suggests that they are functionally distinct and that they might be involved in different processes requiring cap recognition. (Author)

  20. Developing a social media platform for nurses.

    Science.gov (United States)

    Jackson, Jennifer; Kennedy, Maggie

    2015-11-18

    Social media tools provide opportunities for nurses to connect with colleagues and patients and to advance personally and professionally. This article describes the process of developing an innovative social media platform at a large, multi-centre teaching hospital, The Ottawa Hospital, Canada, and its benefits for nurses. The platform, TOH Nurses, was developed using a nursing process approach, involving assessment, planning, implementation and evaluation. The aim of this initiative was to address the barriers to communication inherent in the large number of nurses employed by the organisation, the physical size of the multi-centre hospital and the shift-work nature of nursing. The platform was used to provide educational materials for clinical nurses, and to share information about professional practice. The implications of using a social media platform in a healthcare setting were considered carefully during its development and implementation, including concerns regarding privacy and confidentiality. PMID:26576914

  1. Developing a social media platform for nurses.

    Science.gov (United States)

    Jackson, Jennifer; Kennedy, Maggie

    2015-11-18

    Social media tools provide opportunities for nurses to connect with colleagues and patients and to advance personally and professionally. This article describes the process of developing an innovative social media platform at a large, multi-centre teaching hospital, The Ottawa Hospital, Canada, and its benefits for nurses. The platform, TOH Nurses, was developed using a nursing process approach, involving assessment, planning, implementation and evaluation. The aim of this initiative was to address the barriers to communication inherent in the large number of nurses employed by the organisation, the physical size of the multi-centre hospital and the shift-work nature of nursing. The platform was used to provide educational materials for clinical nurses, and to share information about professional practice. The implications of using a social media platform in a healthcare setting were considered carefully during its development and implementation, including concerns regarding privacy and confidentiality.

  2. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  3. EPA Geospatial Platform

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Geospatial Platform is a shared infrastructure that a suite of geospatial tools, data and services that helps coordinate and consolidate mapping activities,...

  4. Identification of platform levels

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik

    2005-01-01

    and efficient tool. Transforming product development from single to multiple product development is a significant change in product development often involving major changes of product models, procedures and organization. In the area of product models a set of new models has to be introduced, e.g. models......These years many companies are changing their product development from single to multi product development, meaning that not only one product is developed but product families. There are many reasons for this change, but among the most important ones are reduction of time to market, total cost...... of the platform including interfaces are necessary. Procedures change because platform based product development requires a clear distinction between preparation (i.e. development of the platform) and development of individual products (i.e. application of the platform). The organization often has to be changed...

  5. "Platform" innovative educational technology

    OpenAIRE

    Klimashova Yuliya Igorevna

    2015-01-01

    This article reflects the main aspects of "Platform" innovative education technology, determines the theoretical and practical components of the technology, and describes the results of its application in the educational process.

  6. An accuracy assessment of the CALIOP/CALIPSO version 2/version 3 daytime aerosol extinction product based on a detailed multi-sensor, multi-platform case study

    Directory of Open Access Journals (Sweden)

    M. Kacenelenbogen

    2011-04-01

    Full Text Available The Cloud Aerosol LIdar with Orthogonal Polarization (CALIOP, on board the CALIPSO platform, has measured profiles of total attenuated backscatter coefficient (level 1 products since June 2006. CALIOP's level 2 products, such as the aerosol backscatter and extinction coefficient profiles, are retrieved using a complex succession of automated algorithms. The goal of this study is to help identify potential shortcomings in the CALIOP version 2 level 2 aerosol extinction product and to illustrate some of the motivation for the changes that have been introduced in the next version of CALIOP data (version 3, released in June 2010. To help illustrate the potential factors contributing to the uncertainty of the CALIOP aerosol extinction retrieval, we focus on a one-day, multi-instrument, multiplatform comparison study during the CALIPSO and Twilight Zone (CATZ validation campaign on 4 August 2007. On that day, we observe a consistency in the Aerosol Optical Depth (AOD values recorded by four different instruments (i.e. space-borne MODerate Imaging Spectroradiometer, MODIS: 0.67 and POLarization and Directionality of Earth's Reflectances, POLDER: 0.58, airborne High Spectral Resolution Lidar, HSRL: 0.52 and ground-based AErosol RObotic NETwork, AERONET: 0.48 to 0.73 while CALIOP AOD is a factor of two lower (0.32 at 532 nm. This case study illustrates the following potential sources of uncertainty in the CALIOP AOD: (i CALIOP's low signal-to-noise ratio (SNR leading to the misclassification and/or lack of aerosol layer identification, especially close to the Earth's surface; (ii the cloud contamination of CALIOP version 2 aerosol backscatter and extinction profiles; (iii potentially erroneous assumptions of the aerosol extinction-to-backscatter ratio (Sa used in CALIOP's extinction retrievals; and (iv calibration coefficient biases in the CALIOP daytime attenuated backscatter coefficient profiles. The use of version 3 CALIOP extinction

  7. Innovating Platform Business Models

    OpenAIRE

    Moser, Daniel; Gassmann, Oliver

    2016-01-01

    Digitalization, connected products and services, and shortening innovation cycles are widely discussed topics in management practice and theory and demand for new concepts. Platforms are such a concept and find successively entry into a growing number of companies. However, research did not yet address how business models for platforms can be innovated. Thus, we build on a multi-case study and analyze how three major companies, Amazon, Apple and Google innovated their business models. We foun...

  8. Quantifying Solar Wind-Polar Cap Interactions

    Science.gov (United States)

    Urban, K. D.; Gerrard, A. J.; Lanzerotti, L. J.; Weatherwax, A. T.; Huang, Y.

    2015-12-01

    It is well known that the solar wind is a major driver of ultra-low frequency [ULF] power at ground locations from low to high latitudes. However, due to the scarcity of deep polar cap magnetometer sites, it is not clear when, where, or if this is true deep inside the polar cap on open field lines where interplanetary magnetic field [IMF] ULF waves could possibly be directly detected. Given recent observations of very large Joule heating estimates from DMSP data, together with the large heating reported by the CHAMP satellite, it is important to understand the degree to which ULF waves in the solar wind can directly cause such heating. Using a time series of lagged correlation sequences ("dynamic correlograms") between GSM Bz ULF power (computed via data obtained from NASA's Advanced Composition Explorer [ACE] ahead of Earth in the solar wind) and the horizontal ULF power (H^2=N^2+E^2) from ground-based magnetometers in Earth's southern polar cap, we investigate the direct penetration of ULF waves from the solar wind into the polar ionosphere during a gamut of space weather conditions at a distributed network of Automated Geophysical Observatories [AGOs] in Antarctica. To infer causation, a predicted lag correlation maximum at each time step is computed by simply dividing the associated distance of ACE from Earth by the concurrent bulk solar wind speed. This technique helps parse out direct penetration of solar wind ULF waves from other sources (e.g., via leakage from closed field line resonances due to the bulk solar wind plasma viscously interacting at dawn/dusk flanks inducing Kelvin-Helmholtz instabilities [KHI] or compressional modes induced by impulses in solar wind dynamic pressure). The identified direct-penetrating ULF waves are related to the DMSP-derived Poynting fluxes by regression analysis, and conclusions are drawn for the importance of the ULF source for the measured heating.

  9. Recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap.

    Directory of Open Access Journals (Sweden)

    Yasuhiro Takeuchi

    Full Text Available Homologous recombination is a dominant force in evolution and results in genetic mosaics. To detect evidence of recombination events and assess the biological significance of genetic mosaics, genome sequences for various viral populations of reasonably large size are now available in the GenBank. We studied a multi-functional viral gene, the adeno-associated virus (AAV cap gene, which codes for three capsid proteins, VP1, VP2 and VP3. VP1-3 share a common C-terminal domain corresponding to VP3, which forms the viral core structure, while the VP1 unique N-terminal part contains an enzymatic domain with phospholipase A2 activity. Our recombinant detection program (RecI revealed five novel recombination events, four of which have their cross-over points in the N-terminal, VP1 and VP2 unique region. Comparison of phylogenetic trees for different cap gene regions confirmed discordant phylogenies for the recombinant sequences. Furthermore, differences in the phylogenetic tree structures for the VP1 unique (VP1u region and the rest of cap highlighted the mosaic nature of cap gene in the AAV population: two dominant forms of VP1u sequences were identified and these forms are linked to diverse sequences in the rest of cap gene. This observation together with the finding of frequent recombination in the VP1 and 2 unique regions suggests that this region is a recombination hot spot. Recombination events in this region preserve protein blocks of distinctive functions and contribute to convergence in VP1u and divergence of the rest of cap. Additionally the possible biological significance of two dominant VP1u forms is inferred.

  10. The Platformization of the Web: Making Web Data Platform Ready

    NARCIS (Netherlands)

    A. Helmond

    2015-01-01

    In this article, I inquire into Facebook’s development as a platform by situating it within the transformation of social network sites into social media platforms. I explore this shift with a historical perspective on, what I refer to as, platformization, or the rise of the platform as the dominant

  11. The ESA Geohazard Exploitation Platform

    Science.gov (United States)

    Bally, Philippe; Laur, Henri; Mathieu, Pierre-Philippe; Pinto, Salvatore

    2015-04-01

    Earthquakes represent one of the world's most significant hazards in terms both of loss of life and damages. In the first decade of the 21st century, earthquakes accounted for 60 percent of fatalities from natural disasters, according to the United Nations International Strategy for Disaster Reduction (UNISDR). To support mitigation activities designed to assess and reduce risks and improve response in emergency situations, satellite EO can be used to provide a broad range of geo-information services. This includes for instance crustal block boundary mapping to better characterize active faults, strain rate mapping to assess how rapidly faults are deforming, soil vulnerability mapping to help estimate how the soil is behaving in reaction to seismic phenomena, geo-information to assess the extent and intensity of the earthquake impact on man-made structures and formulate assumptions on the evolution of the seismic sequence, i.e. where local aftershocks or future main shocks (on nearby faults) are most likely to occur. In May 2012, the European Space Agency and the GEO Secretariat convened the International Forum on Satellite EO for Geohazards now known as the Santorini Conference. The event was the continuation of a series of international workshops such as those organized by the Geohazards Theme of the Integrated Global Observing Strategy Partnership. In Santorini the seismic community has set out a vision of the EO contribution to an operational global seismic risk program, which lead to the Geohazard Supersites and Natural Laboratories (GSNL) initiative. The initial contribution of ESA to suuport the GSNL was the first Supersites Exploitation Platform (SSEP) system in the framework of Grid Processing On Demand (GPOD), now followed by the Geohazard Exploitation Platform (GEP). In this presentation, we will describe the contribution of the GEP for exploiting satellite EO for geohazard risk assessment. It is supporting the GEO Supersites and has been further

  12. Macrophage Capping Protein CapG Is a Putative Oncogene Involved in Migration and Invasiveness in Ovarian Carcinoma

    Directory of Open Access Journals (Sweden)

    J. Glaser

    2014-01-01

    Full Text Available The actin binding protein CapG modulates cell motility by interacting with the cytoskeleton. CapG is associated with tumor progression in different nongynecologic tumor entities and overexpression in breast cancer cell lines correlates with a more invasive phenotype in vitro. Here, we report a significant CapG overexpression in 18/47 (38% of ovarian carcinomas (OC analyzed by qRealTime-PCR analyses. Functional analyses in OC cell lines through siRNA mediated CapG knockdown and CapG overexpression showed CapG-dependent cell migration and invasiveness. A single nucleotide polymorphism rs6886 inside the CapG gene was identified, affecting a CapG phosphorylation site and thus potentially modifying CapG function. The minor allele frequency (MAF of SNP rs6886 (c.1004A/G was higher and the homozygous (A/A, His335 genotype was significantly more prevalent in patients with fallopian tube carcinomas (50% as in controls (10%. With OC being one of the most lethal cancer diseases, the detection of novel biomarkers such as CapG could reveal new diagnostic and therapeutic targets. Moreover, in-depth analyses of SNP rs6886 related to FTC and OC will contribute to a better understanding of carcinogenesis and progression of OC.

  13. MFTF-. cap alpha. + T progress report

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, W.D. (ed.)

    1985-04-01

    Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; they will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.

  14. Selection of satellite constellation framework of CAPS

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Based on the idea of transmitting the satellite navigation and positioning system, taking the distribution and variation of the Position Dilution of Precision factor (PDOP), which is closely related with the precision of navigation and positioning, within the China area as the primary criterion, we analyze and discuss the tentative plan of constellation configuration consisting of geosynchronous orbit (GEO) communication satellites and inclined geosynchronous orbit (IGSO) satellites for the transmitting Chinese Area Positioning System (CAPS). We emphatically consider the effect on the PDOP by the three major orbit parameters including the inclination, eccentricity and right ascension of the ascend- ing node (RAAN) of IGSO satellites, to research the strategies of the constellation configuration of CAPS through software emulation. Various constellation configurations are analyzed and compared and the results show that the constellation configuration, consisting of three IGSO communication satellites in three orbits with the same inclination as 50°, the difference in RAAN as 120° and the same "8" shaped ground track centered near 115°E and four or five GEO communication satellites within 60°E to 150°E, can satisfy the requirement that Chinese domain is availably covered and the navigation and positioning with high precision could be obtained. Three relatively excellent constellation configurations are initially suggested and some concerned issues are discussed in this work.

  15. Magnetically capped rolled-up nanomembranes.

    Science.gov (United States)

    Streubel, Robert; Thurmer, Dominic J; Makarov, Denys; Kronast, Florian; Kosub, Tobias; Kravchuk, Volodymyr; Sheka, Denis D; Gaididei, Yuri; Schäfer, Rudolf; Schmidt, Oliver G

    2012-08-01

    Modifying the curvature in magnetic nanostructures is a novel and elegant way toward tailoring physical phenomena at the nanoscale, allowing one to overcome limitations apparent in planar counterparts. Here, we address curvature-driven changes of static magnetic properties in cylindrically curved magnetic segments with different radii of curvature. The curved architectures are prepared by capping nonmagnetic micrometer- and nanometer-sized rolled-up membranes with a soft-magnetic 20 nm thick permalloy (Ni(80)Fe(20)) film. A quantitative comparison between the magnetization reversal processes in caps with different diameters is given. The phase diagrams of magnetic equilibrium domain patterns (diameter versus length) are generated. For this, joint experimental, including X-ray magnetic circular dichroism photoelectron emission microscopy (XMCD-PEEM), and theoretical studies are carried out. The anisotropic magnetostatic interaction in cylindrically curved architectures originating from the thickness gradient reduces substantially the magnetostatic interaction between closely packed curved nanowires. This feature is beneficial for racetrack memory devices, since a much higher areal density might be achieved than possible with planar counterparts.

  16. Comparison of Polar Cap (PC) index calculations.

    Science.gov (United States)

    Stauning, P.

    2012-04-01

    The Polar Cap (PC) index introduced by Troshichev and Andrezen (1985) is derived from polar magnetic variations and is mainly a measure of the intensity of the transpolar ionospheric currents. These currents relate to the polar cap antisunward ionospheric plasma convection driven by the dawn-dusk electric field, which in turn is generated by the interaction of the solar wind with the Earth's magnetosphere. Coefficients to calculate PCN and PCS index values from polar magnetic variations recorded at Thule and Vostok, respectively, have been derived by several different procedures in the past. The first published set of coefficients for Thule was derived by Vennerstrøm, 1991 and is still in use for calculations of PCN index values by DTU Space. Errors in the program used to calculate index values were corrected in 1999 and again in 2001. In 2005 DMI adopted a unified procedure proposed by Troshichev for calculations of the PCN index. Thus there exists 4 different series of PCN index values. Similarly, at AARI three different sets of coefficients have been used to calculate PCS indices in the past. The presentation discusses the principal differences between the various PC index procedures and provides comparisons between index values derived from the same magnetic data sets using the different procedures. Examples from published papers are examined to illustrate the differences.

  17. PANDA EMC backward end-cap mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Capozza, Luigi; Ceballos, Jorge; Lin, Dexu; Maas, Frank; Rodriguez, David; Valente, Roserio; Welzel, Felix [Helmholtz-Institut Mainz (Germany); Collaboration: PANDA-Collaboration

    2013-07-01

    The PANDA experiment at the FAIR facility will be a multipurpose hermetic spectrometer covering the full solid angle range. A key role for several physics cases will be played by the electromagnetic calorimeter. This includes ca. 15000 PbWO{sub 4} scintillating crystals arranged in a central barrel, a forward and a backward end-cap. The backward end-cap of the PANDA electromagnetic calorimeter is composed by 540 straight crystals covering the scattering angles between 147 {sup circle} and 161 {sup circle}. They are housed in the so-called alveoli which are carbon fibre boxes, providing both strength and low material budget. The crystals are to work at -25 C in order to improve the light yield. To achieve this temperature a cooling system and thermal insulation are needed. The cooling system removes the heat coming from the electronics and through walls, cables and mechanical supports. Vacuum insulated panels are installed as a thermal shielding. Avalanche Photodiodes (APD) have been chosen as photon detectors, since they are still functional under strong magnetic fields. ASIC chips will be used to amplify the APD signal, this preamplifier features low noise and low heat generation. Due to the weight of this detector, it will be supported from the outside of the PANDA target spectrometer in a counter lever arm position.

  18. Arrays of magnetic nanoparticles capped with alkylamines

    Indian Academy of Sciences (India)

    P John Thomas; P Saravanan; G U Kulkarni; C N R Rao

    2002-02-01

    Magnetic metal and metal oxide nanoparticles capped with alkylamines have been synthesized and characterized by transmission electron microscopy, X-ray diffraction, energy dispersive X-ray analysis and magnetization measurements. Core-shell Pd–Ni particles with composition, Pd561Ni3000, (diameter ∼ 3.3 nm) are superparamagnetic at 5 K and organize themselves into two-dimensional crystalline arrays. Similar arrays are obtained with Pd561Ni3000Pd1500 nanoparticles containing an additional Pd shell. Magnetic spinel particles of -Fe2O3, Fe3O4 and CoFe2O4 of average diameters in the 4–6 nm range coated with octylamine are all supermagnetic at room temperature and yield close-packed disordered arrays. Relatively regular arrays are formed by dodecylamine-capped Fe3O4 nanoparticles (∼ 8.6 nm diameter) while well-ordered hexagonal arrays were obtained with octylamine-covered Co3O4 nanoparticles (∼ 4.2 nm diameter).

  19. Platform-based production development

    DEFF Research Database (Denmark)

    Bossen, Jacob; Brunoe, Thomas Ditlev; Nielsen, Kjeld

    2015-01-01

    Platforms as a means for applying modular thinking in product development is relatively well studied, but platforms in the production system has until now not been given much attention. With the emerging concept of platform-based co-development the importance of production platforms is though...

  20. Transactional Network Platform: Applications

    Energy Technology Data Exchange (ETDEWEB)

    Katipamula, Srinivas; Lutes, Robert G.; Ngo, Hung; Underhill, Ronald M.

    2013-10-31

    In FY13, Pacific Northwest National Laboratory (PNNL) with funding from the Department of Energy’s (DOE’s) Building Technologies Office (BTO) designed, prototyped and tested a transactional network platform to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). Initially, in FY13, the concept demonstrated transactions between packaged rooftop air conditioners and heat pump units (RTUs) and the electric grid using applications or "agents" that reside on the platform, on the equipment, on a local building controller or in the Cloud. The transactional network project is a multi-lab effort with Oakridge National Laboratory (ORNL) and Lawrence Berkeley National Laboratory (LBNL) also contributing to the effort. PNNL coordinated the project and also was responsible for the development of the transactional network (TN) platform and three different applications associated with RTUs. This document describes two applications or "agents" in details, and also summarizes the platform. The TN platform details are described in another companion document.

  1. Acoustic Monitoring of the Arctic Ice Cap

    Science.gov (United States)

    Porter, D. L.; Goemmer, S. A.; Chayes, D. N.

    2012-12-01

    Introduction The monitoring of the Arctic Ice Cap is important economically, tactically, and strategically. In the scenario of ice cap retreat, new paths of commerce open, e.g. waterways from Northern Europe to the Far East. Where ship-going commerce is conducted, the U.S. Navy and U.S. Coast Guard have always stood guard and been prepared to assist from acts of nature and of man. It is imperative that in addition to measuring the ice from satellites, e.g. Icesat, that we have an ability to measure the ice extent, its thickness, and roughness. These parameters play an important part in the modeling of the ice and the processes that control its growth or shrinking and its thickness. The proposed system consists of three subsystems. The first subsystem is an acoustic source, the second is an array of geophones and the third is a system to supply energy and transmit the results back to the analysis laboratory. The subsystems are described below. We conclude with a plan on how to tackle this project and the payoff to the ice cap modeler and hence the users, i.e. commerce and defense. System Two historically tested methods to generate a large amplitude multi-frequency sound source include explosives and air guns. A new method developed and tested by the University of Texas, ARL is a combustive Sound Source [Wilson, et al., 1995]. The combustive sound source is a submerged combustion chamber that is filled with the byproducts of the electrolysis of sea water, i.e. Hydrogen and Oxygen, an explosive mixture which is ignited via a spark. Thus, no additional compressors, gases, or explosives need to be transported to the Arctic to generate an acoustic pulse capable of the sediment and the ice. The second subsystem would be geophones capable of listening in the O(10 Hz) range and transmitting that data back to the laboratory. Thus two single arrays of geophones arranged orthogonal to each other with a range of 1000's of kilometers and a combustive sound source where the two

  2. Analysis list: Cap-H2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Cap-H2 Cell line + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Cap-H2....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Cap-H2.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Ca...p-H2.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Cap-H2.Cell_line.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Cell_line.gml ...

  3. Design and Performance of Capping Layers for EUV Multilayer Mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Bajt, S; Chapman, H N; Nuygen, N; Alameda, J; Robinson, J C; Malinowski, M; Gullikson, E; Aquila, A; Tarrio, C; Grantham, S

    2003-03-10

    The reflectance stability of multilayer coatings for extreme ultraviolet lithography (EUVL) in a commercial tool environment is of uttermost importance to ensure continuous exposures with minimum maintenance cost. We have made substantial progress in designing the protective capping layer coatings, understanding their performance and estimating their lifetimes based on accelerated electron beam and EUV exposure studies. Our current capping layer coatings have about 40 times longer lifetimes than Si-capped multilayer optics. Nevertheless, the lifetime of current Ru-capped multilayers is too short to satisfy commercial tool requirements and further improvements are essential.

  4. Analyses of Current And Wave Forces on Velocity Caps

    DEFF Research Database (Denmark)

    Christensen, Erik Damgaard; Buhrkall, Jeppe; Eskesen, Mark C. D.;

    2015-01-01

    Velocity caps are often used in connection with for instance offshore intake sea water for the use of for cooling water for power plants or as a source for desalinization plants. The intakes can also be used for river intakes. The velocity cap is placed on top of a vertical pipe. The vertical pipe......) this paper investigates the current and wave forces on the velocity cap and the vertical cylinder. The Morison’s force model was used in the analyses of the extracted force time series in from the CFD model. Further the distribution of the inlet velocities around the velocity cap was also analyzed in detail...

  5. Effect of swim cap model on passive drag.

    Science.gov (United States)

    Gatta, Giorgio; Zamparo, Paola; Cortesi, Matteo

    2013-10-01

    Hydrodynamics plays an important role in swimming because even small decreases in a swimmer's drag can lead to performance improvements. During the gliding phases of a race, the head of a swimmer is an important point of impact with the fluid, and the swim cap, even if it covers only a small portion of the swimmer's body, can have an influence on drag. The purpose of this study was to investigate the effects on passive drag (Dp) of wearing 3 different types of swim caps (LSC: a lycra cap; CSC: a silicone cap; HSC: a silicone helmet cap without seams). Sixteen swimmers were tested at 3 velocities (1.5, 1.7, 1.9 m·s), and the Dp measurements were repeated at each condition 5 times. A statistical analysis revealed significant differences in drag (p swim cap is the most rigid, the most adherent to the swimmer's head, and does not allow the formation of wrinkles compared with the other 2 investigated swim caps. Therefore, the following conclusions can be made: (a) swimmers should take care when selecting their swim cap if they want to improve the fluid dynamics at the "leading edge" of their body and (b) because Dp is affected by the swim cap model, care should be taken when comparing data from different studies, especially at faster investigated speeds.

  6. Universal visualization platform

    Science.gov (United States)

    Gee, Alexander G.; Li, Hongli; Yu, Min; Smrtic, Mary Beth; Cvek, Urska; Goodell, Howie; Gupta, Vivek; Lawrence, Christine; Zhou, Jainping; Chiang, Chih-Hung; Grinstein, Georges G.

    2005-03-01

    Although there are a number of visualization systems to choose from when analyzing data, only a few of these allow for the integration of other visualization and analysis techniques. There are even fewer visualization toolkits and frameworks from which one can develop ones own visualization applications. Even within the research community, scientists either use what they can from the available tools or start from scratch to define a program in which they are able to develop new or modified visualization techniques and analysis algorithms. Presented here is a new general-purpose platform for constructing numerous visualization and analysis applications. The focus of this system is the design and experimentation of new techniques, and where the sharing of and integration with other tools becomes second nature. Moreover, this platform supports multiple large data sets, and the recording and visualizing of user sessions. Here we introduce the Universal Visualization Platform (UVP) as a modern data visualization and analysis system.

  7. Microbial diversity on Icelandic glaciers and ice caps

    Directory of Open Access Journals (Sweden)

    Stefanie eLutz

    2015-04-01

    Full Text Available Algae are important primary colonizers of snow and glacial ice, but hitherto little is known about their ecology on Iceland’s glaciers and ice caps. Due do the close proximity of active volcanoes delivering large amounts of ash and dust, they are special ecosystems. This study provides the first investigation of the presence and diversity of microbial communities on all major Icelandic glaciers and ice caps over a three year period. Using high-throughput sequencing of the small subunit ribosomal RNA genes (16S and 18S, we assessed the snow community structure and complemented these analyses with a comprehensive suite of physical-, geo- and biochemical characterizations of the aqueous and solid components contained in snow and ice samples. Our data reveal that a limited number of snow algal taxa (Chloromonas polyptera, Raphidonema sempervirens and two uncultured Chlamydomonadaceae support a rich community comprising of other micro-eukaryotes, bacteria and archaea. Proteobacteria and Bacteroidetes were the dominant bacterial phyla. Archaea were also detected in sites where snow algae dominated and they mainly belong to the Nitrososphaerales, which are known as important ammonia oxidizers. Multivariate analyses indicated no relationships between nutrient data and microbial community structure. However, the aqueous geochemical simulations suggest that the microbial communities were not nutrient limited because of the equilibrium of snow with the nutrient-rich and fast dissolving volcanic ash. Increasing algal secondary carotenoid contents in the last stages of the melt seasons have previously been associated with a decrease in surface albedo, which in turn could potentially have an impact on the melt rates of Icelandic glaciers.

  8. Industry Platforms and Ecosystem Innovation

    OpenAIRE

    Gawer, Annabelle; Cusumano, Michael A., 1954-

    2013-01-01

    This paper brings together the recent literature on industry platforms and shows how it relates to managing innovation within and outside the firm as well as to dealing with technological and market disruptions and change over time. First, we identify distinct types of platforms. Our analysis of a wide range of industry examples suggests that there are two predominant types of platforms: internal or company-specific platforms, and external or industry-wide platforms. We define internal (compa...

  9. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2010-01-01

    The Azure Services Platform is a brand-new cloud-computing technology from Microsoft. It is composed of four core components-Windows Azure, .NET Services, SQL Services, and Live Services-each with a unique role in the functioning of your cloud service. It is the goal of this book to show you how to use these components, both separately and together, to build flawless cloud services. At its heart Windows Azure Platform is a down-to-earth, code-centric book. This book aims to show you precisely how the components are employed and to demonstrate the techniques and best practices you need to know

  10. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2011-01-01

    The Windows Azure Platform has rapidly established itself as one of the most sophisticated cloud computing platforms available. With Microsoft working to continually update their product and keep it at the cutting edge, the future looks bright - if you have the skills to harness it. In particular, new features such as remote desktop access, dynamic content caching and secure content delivery using SSL make the latest version of Azure a more powerful solution than ever before. It's widely agreed that cloud computing has produced a paradigm shift in traditional architectural concepts by providin

  11. Study on Alignment Technology of CAP1400 Reactor Internals%CAP1400堆内构件对中检测技术研究

    Institute of Scientific and Technical Information of China (English)

    舒华安; 童庆军; 王盛; 郝磊; 郭健

    2016-01-01

    对中检测是CAP1400堆内构件制造装配的关键检测技术,针对传统光学对中方法的检测结果易受环境和人眼观测误差影响,且作业时间受限等缺点,开发了激光垂准—CCD光靶数据采集处理的新型对中检测方法。通过专用试验平台进行对中比对试验,结果表明该方法测量精度高,成功避免了传统方法的缺点,为堆内构件制造及核电站现场安装提供了新的对中检测方法。%The alignment measurement is the key technology of CAP1400 reactor interal manufacturing and assembly. Traditional method using micrometer collimating telescope has high requirements on the operating environment, operation time. The system of Laser Vertical-CCD optical target data acquisition and processing is developed. The comparison tests made through the special test platform show that the method has high accuracy of measurement. The disadvantages of the traditional optical measurement is avoided. A new method for manufacturing and installation of reactor internal is gained.

  12. Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP – Results from the German competence network CAPNETZ

    Directory of Open Access Journals (Sweden)

    von Baum Heike

    2009-07-01

    Full Text Available Abstract Background Aim of this study was to evaluate the correlation of inflammatory markers procalcitonin (PCT, C-reactive protein (CRP and leukocyte count (WBC with microbiological etiology of CAP. Methods We enrolled 1337 patients (62 ± 18 y, 45% f with proven CAP. Extensive microbiological workup was performed. In all patients PCT, CRP, WBC and CRB-65 score were determined. Patients were classified according to microbial diagnosis and CRB-65 score. Results In patients with typical bacterial CAP, levels of PCT, CRP and WBC were significantly higher compared to CAP of atypical or viral etiology. There were no significant differences in PCT, CRP and WBC in patients with atypical or viral etiology of CAP. In contrast to CRP and WBC, PCT markedly increased with severity of CAP as measured by CRB-65 score (p 1, AUC for PCT was 0.69 (95% CI 0.66 to 0.71, which was higher compared to CRP and WBC (p Conclusion PCT, CRP and WBC are highest in typical bacterial etiology in CAP but do not allow individual prediction of etiology. In contrast to CRP and WBC, PCT is useful in severity assessment of CAP.

  13. Development of the Continuous Acquisition Pixel (CAP) sensor for high luminosity lepton colliders

    Energy Technology Data Exchange (ETDEWEB)

    Varner, G. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States)]. E-mail: varner@phys.hawaii.edu; Aihara, H. [Department of Physics, University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033 (Japan); Barbero, M. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Bozek, A. [H. Niewoniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Ul. Radzikowskiego 152, 31-342 Cracow (Poland); Browder, T. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Hazumi, M. [KEK, High Energy Accelerator Research Organization, Oho 1-1, Tsukuba 305-0801 (Japan); Kennedy, J.; Martin, E. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Mueller, J. [Department of Physics and Astronomy, University of Pittsburg, 3941 O' Hara Street, Pittsburg, PA 15260 (United States); Olsen, S. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Palka, H. [H. Niewoniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Ul. Radzikowskiego 152, 31-342 Cracow (Poland); Rosen, M.; Ruckman, L. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Stanic, S. [Nova Gorica Polytechnic, Vipavska 13, 5000 Nova Gorica (Slovenia); Trabelsi, K. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Tsuboyama, T. [KEK, High Energy Accelerator Research Organization, Oho 1-1, Tsukuba 305-0801 (Japan); Uchida, K.; Yang, Q. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Yarema, R. [Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States)

    2006-09-01

    A future higher luminosity B-factory detector and concept study detectors for the proposed International Linear Collider require precision vertex reconstruction while coping with high track densities and radiation exposures. Compared with current silicon strip and hybrid pixels, a significant reduction in the overall detector material thickness is needed to achieve the desired vertex resolution. Considerable progress in the development of thin CMOS-based Monolithic Active Pixel Sensors (MAPS) in recent years makes them a viable technology option and feasibility studies are being actively pursued. The most serious concerns are their radiation hardness and their readout speed. To address these, several prototypes denoted as the Continuous Acquisition Pixel (CAP) sensors have been developed and tested. The latest of the CAP sensor prototypes is CAP3, designed in the TSMC 0.25{mu}m process with a 5-deep Correlated Double Sample (CDS) pair pipeline in each pixel. A setup with several CAP3 sensors is under evaluation to assess the performance of a full-scale pixel readout system running at realistic readout speed. Given the similarity in the occupancy numbers and hit throughput requirements, per unit area, between a Belle vertex detector upgradation and the requirements for a future ILC pixel detector, this effort can be considered a small-scale functioning prototype for such a future system. The results and plans for the next stages of R and D towards a full Belle Pixel Vertex Detector (PVD) are presented.

  14. Plastic and paper platforms for nanoparticle based immunosensors

    OpenAIRE

    Parolo, Claudio

    2013-01-01

    La tesis titulada “Plastic and paper platforms for nanoparticle based immunosensors” presentada como compendio de publicaciones, muestra avances significativos en el campo de los biosensores ópticos y electroquímicos. En la introducción (Capítulo 1) se presenta la importancia que tienen tanto los sensores inmunológicos basados en nanopartículas como los biosensores basados en plataformas de papel y nanomateriales para aplicaciones en diagnóstico. Ambas plataformas destacan por la versa...

  15. Carpentier, la otra novela (cap. IV

    Directory of Open Access Journals (Sweden)

    Urbano Martínez Carmenate

    2014-07-01

    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  16. Carpentier, la otra novela (cap. IV

    Directory of Open Access Journals (Sweden)

    Urbano Martínez Carmenate

    2014-06-01

    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  17. Bottom Fixed Platform Dynamics Models Assessing Surface Ice Interactions for Transitional Depth Structures in the Great Lakes: FAST8 – IceDyn

    Energy Technology Data Exchange (ETDEWEB)

    Karr, Dale G. [Univ. of Michigan, Ann Arbor, MI (United States); Yu, Bingbin [Principle Power, Inc., Emeryville, CA (United States); Sirnivas, Senu [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-04-01

    base, were compared. Ice models 1 and 6 do not significantly affect the tower fore-aft shear and moment. However, ice model 2 (dynamic analyses), model 3 (random ice loading), and model 4 (multiple ice failure zone loading) show increased effect on the tower fore-aft shear and moment with significant effect from ice model 3.1. In general ice loading creates large reaction forces and moments at the base of the IBGS foundation; the largest occurred in model 1.1 (steady creep ice indentation loading) followed by model 3.1 (random creep ice indentation loading). In general the power production from the ice loading cases had little deviation from the baseline case without ice loading. For ultimate limit state (ULS), ice model 1.1 ice and 3.1 appear to be the ice most critical models to consider at an early stage of design. Ice model 4 is an important tool for assessing structural fatigue.

  18. Postgraduate programmes as platform

    NARCIS (Netherlands)

    Swet, Jacqueline van; Ponte, Petra; Smit, Ben

    2007-01-01

    Typical of postgraduate courses for experienced teachers is the wealth of professional experience that the studetns bring with them. Such students can examine their own practice, for which they are fully responsible. Authors from diverse backgrounds address important aspects of the platform, such as

  19. Creative Platform Learning (CPL)

    DEFF Research Database (Denmark)

    Christensen, Jonna Langeland; Hansen, Søren

    Creative Platform Learning (CPL) er en pædagogisk metode, der skaber foretagsomme og innovative elever, der kan anvende deres kreativitet til at lære nyt. Ifølge den nye skolereform skal Innovation og entreprenørskab tydeliggøres i alle fag. I CPL er det en integreret del af undervisningen...

  20. 47 CFR 52.109 - Permanent cap on number reservations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Permanent cap on number reservations. 52.109... (CONTINUED) NUMBERING Toll Free Numbers § 52.109 Permanent cap on number reservations. (a) A Responsible Organization may have in reserve status, at any one time, either 2000 toll free numbers or 7.5 percent of...

  1. 47 CFR 61.41 - Price cap requirements generally.

    Science.gov (United States)

    2010-10-01

    ... party to a merger, acquisition, or similar transaction shall continue to be subject to price cap... no later than one year following the effective date of such merger, acquisition, or similar... subject to price cap regulation, as that term is defined in § 61.3(ee), which are involved in...

  2. ATLAS end-caps 
on the move

    CERN Multimedia

    2007-01-01

    Two delicate and spectacular transport operations have been performed for ATLAS in recent weeks: the first end-cap tracker was installed in its final position, and one of the huge end-caps of the toroid magnet was moved to the top of the experiment’s shaft.

  3. Preparing an ATLAS toroid magnet end-cap for lowering

    CERN Multimedia

    Claudia Marcelloni

    2007-01-01

    One of the two 13-m high toroid magnet end-caps for the ATLAS experiment being transported from the construction hall to the experimental area. The end-cap will be lowered into the ATLAS cavern and attached to an end of the detector.

  4. Regulating Telecommunications : Lessons from U.S. Price Cap Experience

    OpenAIRE

    Jeffrey H. Rohlfs

    1996-01-01

    Price cap regulation uses a formula, set in advance, to determine the price increases for a firm's services for a period of several years. During this period, the firm may keep all the benefits of its incremental productivity gains. Customers can also benefit because the price cap formula may cause prices to rise less rapidly during the period. The sharpened incentives created may encourag...

  5. Temperature Distribution within a Cold Cap during Nuclear Waste Vitrification

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, Derek R.; Schweiger, Michael J.; Riley, Brian J.; Pokorny, Richard; Hrma, Pavel R.

    2015-07-21

    The kinetics of the feed-to-glass conversion affects the waste vitrification rate in an electric melter. The primary area of interest in this conversion process is the cold cap, a layer of reacting feed on top of molten glass. Knowing the temperature profile within a cold cap will help determine its characteristics and relate them to the rate of glass production. The work presented here provides an experimental determination of the temperature distribution within the cold cap. Since a direct measurement of the temperature field within the cold cap is impracticable, an indirect method was developed where the textural features in a laboratory-made cold cap with a high-level waste feed were mapped as a function of position using optical microscopy, scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. To correlate the temperature distribution to microstructures within the cold cap, microstructures were identified of individual feed samples that were heat treated to set temperatures between 400°C and 1200°C and quenched. The temperature distribution within the cold cap was then established by correlating cold-cap regions with the feed samples of nearly identical structures and was compared with the temperature profile from a mathematical model.

  6. IN SITU REMEDIATION OF CONTAMINATED SEDIMENTS - ACTIVE CAPPING TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    Knox, A.; Roberts, J.; Paller, M.; Reible, D.

    2010-09-02

    Active capping is a relatively new approach for treating contaminated sediments. It involves applying chemically reactive amendments to the sediment surface. The main role of active caps is to stabilize contaminants in contaminated sediments, lower the bioavailable pool of contaminants, and reduce the release of contaminants to the water column. Metals are common contaminants in many marine and fresh water environments as a result of industrial and military activities. The mobile, soluble forms of metals are generally considered toxic. Induced chemical precipitation of these metals can shift toxic metals from the aqueous phase to a solid, precipitated phase which is often less bioavailable. This approach can be achieved through application of sequestering agents such as rock phosphates, organoclays, zeolites, clay minerals, and biopolymers (e.g., chitosan) in active capping technology. Active capping holds great potential for a more permanent solution that avoids residual risks resulting from contaminant migration through the cap or breaching of the cap. In addition to identifying superior active capping agents, research is needed to optimize application techniques, application rates, and amendment combinations that maximize sequestration of contaminants. A selected set of active capping treatment technologies has been demonstrated at a few sites, including a field demonstration at the Savannah River Site, Aiken, SC. This demonstration has provided useful information on the effects of sequestering agents on metal immobilization, bioavailability, toxicity, and resistance to mechanical disturbance.

  7. Mobile Platforms and Development Environments

    CERN Document Server

    Helal, Sumi; Li, Wengdong

    2012-01-01

    Mobile platform development has lately become a technological war zone with extremely dynamic and fluid movement, especially in the smart phone and tablet market space. This Synthesis lecture is a guide to the latest developments of the key mobile platforms that are shaping the mobile platform industry. The book covers the three currently dominant native platforms -- iOS, Android and Windows Phone -- along with the device-agnostic HTML5 mobile web platform. The lecture also covers location-based services (LBS) which can be considered as a platform in its own right. The lecture utilizes a sampl

  8. Progress in LAr EndCap Calorimetry: News from the Hadronic EndCap Group.

    CERN Multimedia

    Oram, C.J.

    With module production and testing completed for the Hadronic EndCap calorimeter, the attention of the HEC group is heavily directed towards wheel assembly in building 180. Three of the four HEC wheels are now assembled and rotated, and work is progressing on assembling the final wheel. This year has been a busy year for the installation of components in the EndCap C cryostat: the signal feedthrough installation was completed April 22nd, the pre-sampler shortly thereafter and the Electro-Magnetic EndCap August 13th. This allowed the HEC group to start transferring the HEC wheels from the T6A storage cradle into the cryostat. The operation started in mid-September and has progressed, on or ahead of schedule, since then with the major milestones being: Insertion of 67 ton front HEC wheel October 3rd Insertion of 90 ton rear HEC wheel October 22nd. The wheel alignment has proved to be excellent, with the position of the centre of the front(rear) wheel with respect to the nominal position being displaced b...

  9. APPLICATION OF BP NEURAL NETWORK TO ASSESS THE POLLUTION LEVEL OF OIL SPILL ON THE OFFSHORE PLATFORM%BP网络海上石油平台溢油污染等级评估方法

    Institute of Scientific and Technical Information of China (English)

    郎印海; 刘洁; 贾永刚; 崔文林

    2011-01-01

    Assessment index system of oil spill for the offshore oil platform was established for the first time by analyzing the influenced factors related to the degree of oil pollution. To solve the problem of non-samples, every assessment index was divided into several grades and the Rand function was used to generate enough training samples and test samples. A more reasonable network structure was established and a BP neural network model of the degree of oil pollution was finally set up. The results showed that the model had good generalization, and it not only could be used to evaluate unknown samples but also had a strong practical value.%通过分析与溢油污染程度有关的影响因素,首次构建了海上石油平台溢油污染程度评价指标体系.针对模型无样本的难题,对评价指标进行分级,利用Rand函数在各分级标准内随机生成足够数量的训练和测试样本,建立了较合理的网络结构,构建了石油平台溢油污染等级BP网络模型.研究结果表明BP网络模型具有很强的泛化能力,能够用于评判未知样本,具有较强的实用性.

  10. 关于中医药临床研究伦理审查平台建设评估的思考%Enlightenment and Thinking on Platform Construction Assessment of Ethics Review of Clinical Trail of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    凌丽; 吕祥; 夏英; 朱凌云

    2013-01-01

    By assessment of platform construction assessment of ethics review of Traditional Chinese Medicine (TCM) research,the current problems in construction and development of hospital ethics committee were disclosed,including:lack of independency of ethics committee,lack systematical ethics training for researchers,the deficiency of unified standards in multi-center review,less supervison in subsequent research and the lack of management regulation of quality control and interest conflict.Measures include regulating medical ethics training,setting up a joint ethics committee,formulating local standards,clarificating the management principles of quality control and interest conflict and exploring recognition of ethics committee were proposed.%通过中医药临床研究伦理审查平台建设评估,发现目前医院伦理委员会在建设和发展中存在以下问题:工作缺乏较高的独立性、缺乏针对研究者的系统化伦理培训、多中心审查缺乏统一标准、临床研究后续监管力度不够、缺乏质量管理和利益冲突管理机制等.提出了规范医学伦理学培训、建立联合伦理委员会、制定地方标准、明确质量管理原则和利益冲突防范原则、探索实行伦理委员会认证等对策.

  11. The CAP Theorem Versus Databases with Relaxed ACID properties

    DEFF Research Database (Denmark)

    Frank, Lars; Ulslev Pedersen, Rasmus; Frank, Christian Havnø;

    2014-01-01

    the traditional ACID properties and all the CAP properties were implemented. This optimizing is especially important in mobile integrated databases, where disconnections are normal and frequent. It is also important in distributed databases like EHR (electronic Health Records) where many different hospital...... data from different locations can have at most two of the three desirable CAP properties [5]. The NoSQL movement has applied the CAP theorem as an argument against traditional ACID (atomicity, consistency, isolation, and durability) databases, which prioritize consistency and partition...... availability and sufficient data consistency, despite the presence of network partitions. The overall objective of this paper is to improve the CAP optimization methods by using optimization techniques outside of those preferred in CAP optimization literature. The main contribution is to use relaxed ACID...

  12. Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery.

    Science.gov (United States)

    Chen, Ganchao; Xie, Yusheng; Peltier, Raoul; Lei, Haipeng; Wang, Ping; Chen, Jun; Hu, Yi; Wang, Feng; Yao, Xi; Sun, Hongyan

    2016-05-11

    A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) with functional peptide-coated gold nanoparticles (GNPs). MSNs are first functionalized with acid-labile α-amide-β-carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo-lysine-containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to αvβ3 integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides.

  13. Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery.

    Science.gov (United States)

    Chen, Ganchao; Xie, Yusheng; Peltier, Raoul; Lei, Haipeng; Wang, Ping; Chen, Jun; Hu, Yi; Wang, Feng; Yao, Xi; Sun, Hongyan

    2016-05-11

    A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) with functional peptide-coated gold nanoparticles (GNPs). MSNs are first functionalized with acid-labile α-amide-β-carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo-lysine-containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to αvβ3 integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides. PMID:27102225

  14. Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release

    CERN Document Server

    Datz, Stefan; Gattner, Michael; Weiss, Veronika; Brunner, Korbinian; Bretzler, Johanna; von Schirnding, Constantin; Spada, Fabio; Engelke, Hanna; Vrabel, Milan; Bräuchle, Christoph; Carell, Thomas; Bein, Thomas

    2015-01-01

    Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica nanoparticles (MSNs) that is directly combined with a targeting ligand via bio-orthogonal click chemistry. The capping system is based on the pH-responsive binding of an aryl-sulfonamide-functionalized MSN and the enzyme carbonic anhydrase (CA). An unnatural amino acid (UAA) containing a norbornene moiety was genetically incorporated into CA. This UAA allowed for the site-specific bio-orthogonal attachment of even very sensitive targeting ligands such as folic acid and anandamide. This leads to specific receptor-mediated cell and stem cell uptake. We demonstrate the successful delivery and release of the chemotherapeutic agent Actinomycin D to KB cells. This novel nanocarrier concept provides a promising platform for the development of precisely controllable and highly modular theranos...

  15. Nano-sized calcium phosphate (CaP) carriers for non-viral gene deilvery

    International Nuclear Information System (INIS)

    Highlights: ► Nanostructured calcium phosphates (NanoCaPs): comprehensive review. ► Non viral gene delivery mechanisms: detailed mechanisms are outlined. ► Barriers to non-viral gene delivery: detailed barriers are discussed. - Abstract: Gene therapy has garnered much interest due to the potential for curing multiple inherited and/or increases in the acquired diseases. As a result, there has been intense activity from multiple research groups for developing effective delivery methods and carriers, which is a critical step in advancing gene delivery technologies. In order for the carriers to effectively deliver the genetic payloads, multiple extracellular and intracellular barriers need to be overcome. Although overcoming these challenges to improve the effectiveness is critical, the development of safe gene delivery agents is even more vital to assure its use in clinical applications. The development of safe and effective strategies has therefore been a major challenge impeding gene therapy progress. In this regard, calcium phosphate (CaP) based nano-particles has been considered as one of the candidate non-viral gene delivery vehicles, but has been plagued by inconsistent and low transfection efficiencies limiting its progress. There has been major research effort to improve the consistency and effectiveness of CaP based vectors. Currently, it is therefore thought that by controlling the various synthesis factors such as Ca/P ratio, mode of mixing, and type of calcium phosphate phase, such variability and inefficiency could be modulated. This review attempts to provide a comprehensive analysis of the current research activity in the development of CaP based ceramic and polymer-ceramic hybrid systems for non-viral gene delivery. Preliminary transfection results of hydroxyapatite (HA or NanoCaPs), amorphous calcium phosphate (ACP) and brushite phases are also compared to assess the effect of various CaP phases, and correspondingly, changes in the dissolution

  16. Upgrading platform using alkali metals

    Science.gov (United States)

    Gordon, John Howard

    2014-09-09

    A process for removing sulfur, nitrogen or metals from an oil feedstock (such as heavy oil, bitumen, shale oil, etc.) The method involves reacting the oil feedstock with an alkali metal and a radical capping substance. The alkali metal reacts with the metal, sulfur or nitrogen content to form one or more inorganic products and the radical capping substance reacts with the carbon and hydrogen content to form a hydrocarbon phase. The inorganic products may then be separated out from the hydrocarbon phase.

  17. OGC Collaborative Platform undercover

    Science.gov (United States)

    Buehler, G.; Arctur, D. K.; Bermudez, L. E.

    2012-12-01

    The mission of the Open Geospatial Consortium (OGC) is to serve as a global forum for the collaboration of developers and users of spatial data products and services, and to advance the development of international standards for geospatial interoperability. The OGC coordinates with over 400 institutions in the development of geospatial standards. OGC has a dedicated staff supported by a Collaborative Web Platform to enable sophisticated and successful coordination among its members. Since its origins in the early 1990s, the OGC Collaborative Web Platform has evolved organically to be the collaboration hub for standards development in the exchange of geospatial and related types of information, among a global network of thousands of technical, scientific and management professionals spanning numerous disparate application domains. This presentation describes the structure of this collaboration hub, the relationships enabled (both among and beyond OGC members), and how this network fits in a broader ecosystem of technology development and information standards organizations.

  18. Online stock trading platform

    Directory of Open Access Journals (Sweden)

    Ion LUNGU

    2006-01-01

    Full Text Available The Internet is the perfect tool that can assure the market’s transparency for any user who wants to trade on the stock market. The investor can have access to the market news, financial calendar or the press releases of the issuers. A good online trading platform also provides real-time intraday quotes, trading history and technical analysis giving the investor a clearer view of the supply and demand in the market. All this information provides the investor a good image of the market and encourages him to trade. This paper wishes to draft the pieces of an online trading platform and to analyze the impact of developing and implementing one in a brokerage firm.

  19. Available: motorised platform

    CERN Multimedia

    The COMPASS collaboration

    2014-01-01

    The COMPASS collaboration would like to offer to a new owner the following useful and fully operational piece of equipment, which is due to be replaced with better adapted equipment.   Please contact Erwin Bielert (erwin.bielert@cern.ch or 160539) for further information.  Motorized platform (FOR FREE):   Fabricated by ACL (Alfredo Cardoso & Cia Ltd) in Portugal. The model number is MeXs 5-­‐30.  Specifications: 5 m wide, 1 m deep, adjustable height (1.5 m if folded). Maximum working floor height: 4 m. conforms to CERN regulations, number LV158. Type LD500, capacity 500 kg and weight 2000 kg.  If no interested party is found before December 2014, the platform will be thrown away.

  20. Common tester platform concept.

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, Michael James

    2008-05-01

    This report summarizes the results of a case study on the doctrine of a common tester platform, a concept of a standardized platform that can be applicable across the broad spectrum of testing requirements throughout the various stages of a weapons program, as well as across the various weapons programs. The common tester concept strives to define an affordable, next-generation design that will meet testing requirements with the flexibility to grow and expand; supporting the initial development stages of a weapons program through to the final production and surveillance stages. This report discusses a concept investing key leveraging technologies and operational concepts combined with prototype tester-development experiences and practical lessons learned gleaned from past weapons programs.

  1. Manifold: a Custom Analytics Platform to Visualize Research Impact

    OpenAIRE

    Steven Braun

    2015-01-01

    The use of research impact metrics and analytics has become an integral component to many aspects of institutional assessment. Many platforms currently exist to provide such analytics, both proprietary and open source; however, the functionality of these systems may not always overlap to serve uniquely specific needs. In this paper, I describe a novel web-based platform, named Manifold, that I built to serve custom research impact assessment needs in the University of Minnesota Medical School...

  2. Cloud Robotics Platforms

    Directory of Open Access Journals (Sweden)

    Busra Koken

    2015-01-01

    Full Text Available Cloud robotics is a rapidly evolving field that allows robots to offload computation-intensive and storage-intensive jobs into the cloud. Robots are limited in terms of computational capacity, memory and storage. Cloud provides unlimited computation power, memory, storage and especially collaboration opportunity. Cloud-enabled robots are divided into two categories as standalone and networked robots. This article surveys cloud robotic platforms, standalone and networked robotic works such as grasping, simultaneous localization and mapping (SLAM and monitoring.

  3. Geology of spermonde platform

    OpenAIRE

    A. M. Imran; M.S., Kaharuddin; Suriamihardja, D.A.; Sirajuddin, H.

    2013-01-01

    ABSTRACT: The spermonde islands are a reef complex trending north ??? south in the western coastline of South Sulawesi. The development of the reef is controlled by geological processes forming Makassar Strait. The strait arises since rifting between Kalimantan and Sulawesi in Paleocene Era and followed by spreading to form Makassar Strait. The geological process allows the reef complex developed along the Spermonde platform in the west coast of South Sulawesi. Beside the geological factor (s...

  4. HPC - Platforms Penta Chart

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo, Angelina Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-08

    Strategy, Planning, Acquiring- very large scale computing platforms come and go and planning for immensely scalable machines often precedes actual procurement by 3 years. Procurement can be another year or more. Integration- After Acquisition, machines must be integrated into the computing environments at LANL. Connection to scalable storage via large scale storage networking, assuring correct and secure operations. Management and Utilization – Ongoing operations, maintenance, and trouble shooting of the hardware and systems software at massive scale is required.

  5. Aging Assessment and Reliability Aware Computing Platforms

    NARCIS (Netherlands)

    Wang, Y.

    2013-01-01

    Aggressive CMOS technology feature size scaling has been going on for the past decades, while the supply voltage is not proportionally scaled. Due to the increasing power density and electric field in the gate dielectric, the accelerating factors of failure mechanisms in nanoscale Integrated Circui

  6. The economics of crowdfunding platforms

    OpenAIRE

    Belleflamme, Paul; Omrani, Nessrine; Peitz, Martin

    2015-01-01

    This paper provides a description of the crowdfunding sector, considering investment-based crowdfunding platforms as well as platforms in which funders do not obtain monetary payments. It lays out key features of this quickly developing sector and explores the economic forces at play that can explain the design of these platforms. In particular, it elaborates on cross-group and within-group external effects and asymmetric information on crowdfunding platforms.

  7. The Prodiguer Messaging Platform

    Science.gov (United States)

    Denvil, S.; Greenslade, M. A.; Carenton, N.; Levavasseur, G.; Raciazek, J.

    2015-12-01

    CONVERGENCE is a French multi-partner national project designed to gather HPC and informatics expertise to innovate in the context of running French global climate models with differing grids and at differing resolutions. Efficient and reliable execution of these models and the management and dissemination of model output are some of the complexities that CONVERGENCE aims to resolve.At any one moment in time, researchers affiliated with the Institut Pierre Simon Laplace (IPSL) climate modeling group, are running hundreds of global climate simulations. These simulations execute upon a heterogeneous set of French High Performance Computing (HPC) environments. The IPSL's simulation execution runtime libIGCM (library for IPSL Global Climate Modeling group) has recently been enhanced so as to support hitherto impossible realtime use cases such as simulation monitoring, data publication, metrics collection, simulation control, visualizations … etc. At the core of this enhancement is Prodiguer: an AMQP (Advanced Message Queue Protocol) based event driven asynchronous distributed messaging platform. libIGCM now dispatches copious amounts of information, in the form of messages, to the platform for remote processing by Prodiguer software agents at IPSL servers in Paris. Such processing takes several forms: Persisting message content to database(s); Launching rollback jobs upon simulation failure; Notifying downstream applications; Automation of visualization pipelines; We will describe and/or demonstrate the platform's: Technical implementation; Inherent ease of scalability; Inherent adaptiveness in respect to supervising simulations; Web portal receiving simulation notifications in realtime.

  8. Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ.

    Science.gov (United States)

    Lin, Ying-Hsi; Warren, Chad M; Li, Jieli; McKinsey, Timothy A; Russell, Brenda

    2016-08-01

    The mechanotransduction signaling pathways initiated in heart muscle by increased mechanical loading are known to lead to long-term transcriptional changes and hypertrophy, but the rapid events for adaptation at the sarcomeric level are not fully understood. The goal of this study was to test the hypothesis that actin filament assembly during cardiomyocyte growth is regulated by post-translational modifications (PTMs) of CapZβ1. In rapidly hypertrophying neonatal rat ventricular myocytes (NRVMs) stimulated by phenylephrine (PE), two-dimensional gel electrophoresis (2DGE) of CapZβ1 revealed a shift toward more negative charge. Consistent with this, mass spectrometry identified CapZβ1 phosphorylation on serine-204 and acetylation on lysine-199, two residues which are near the actin binding surface of CapZβ1. Ectopic expression of dominant negative PKCɛ (dnPKCɛ) in NRVMs blunted the PE-induced increase in CapZ dynamics, as evidenced by the kinetic constant (Kfrap) of fluorescence recovery after photobleaching (FRAP), and concomitantly reduced phosphorylation and acetylation of CapZβ1. Furthermore, inhibition of class I histone deacetylases (HDACs) increased lysine-199 acetylation on CapZβ1, which increased Kfrap of CapZ and stimulated actin dynamics. Finally, we show that PE treatment of NRVMs results in decreased binding of HDAC3 to myofibrils, suggesting a signal-dependent mechanism for the regulation of sarcomere-associated CapZβ1 acetylation. Taken together, this dual regulation through phosphorylation and acetylation of CapZβ1 provides a novel model for the regulation of myofibril growth during cardiac hypertrophy. PMID:27185186

  9. Contemporary Internet of Things platforms

    OpenAIRE

    Mineraud, Julien; Mazhelis, Oleksiy; Su, Xiang; Tarkoma, Sasu

    2015-01-01

    This document regroups a representative, but non-exhaustive, list of contemporary IoT platforms. The platforms are ordered alphabetically. The aim of this document is to provide the a quick review of current IoT platforms, as well as relevant information.

  10. Product Platform Screening at LEGO

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Steen Jensen, Thomas; Nielsen, Ole Fiil

    2012-01-01

    Product platforms offer great benefits to companies developing new products in highly competitive markets. Literature describes how a single platform can be designed from a technical point of view, but rarely mentions how the process begins. How do companies identify possible platform candidates...

  11. Trafficking of. cap alpha. -L-fucosidase in lymphoid cells

    Energy Technology Data Exchange (ETDEWEB)

    DiCioccio, R.A.; Brown, K.S.

    1987-05-01

    The quantity of ..cap alpha..-L-fucosidase in human serum is determined by heredity. The mechanism controlling levels of the enzyme in serum is unknown. To investigate this, lymphoid cell lines derived from individuals with either low, intermediate or high ..cap alpha..-L-fucosidase in serum were established. Steady state levels of extracellular ..cap alpha..-L-fucosidase protein and activity overlapped among the cell lines. Thus, in vivo serum phenotypes of ..cap alpha..-L-fucosidase are not adequately expressed in this system. ..cap alpha..-L-Fucosidase was also metabolically labelled with /sup 35/S-methionine, immunoprecipitated, and examined by SDS-PAGE. Cells pulse-labelled from 0.25-2 h had a major intracellular form of enzyme (Mr = 58,000). Cells pulsed for 1.5 h and chased for 21 h with unlabeled methionine had an intracellular form of Mr = 60,000 and an extracellular form of Mr = 62,000. Cells treated with chloroquine had only the 58,000-form both intra- and extra-cellularly. Moreover, chloroquine did not effect the quantitative distribution of ..cap alpha..-L-fucosidase between cells and medium. In fibroblasts, chloroquine enhanced the secretion of newly made lysosomal enzymes and blocked the processing of intercellular enzyme forms from a higher to a lower molecular mass. Thus, there are trafficking differences between ..cap alpha..-L-fucosidase in lymphoid cells and lysosomal enzymes in fibroblasts. This suggests that alternative targeting mechanisms for lysosomal enzymes exist in these cells.

  12. Authentic Assessment in California.

    Science.gov (United States)

    Educational Leadership, 1989

    1989-01-01

    Describes the teacher-developed California Assessment Program (CAP) writing measure, designed to support California's reform curriculum and based on matrix sampling techniques. This program will be supplemented by literature and mathematics assessments. The greatest challenge is designing an assessment to match the state's new history and social…

  13. Thick methacrylate sections devoid of lost caps simplify stereological quantifications based on the optical fractionator design

    DEFF Research Database (Denmark)

    Andersen, Stine Hasselholt; Lykkesfeldt, Jens; Larsen, Jytte Overgaard

    2015-01-01

    and/or optical limitations. Restricting the disector within the section thickness potentially introduces bias in two ways. Firstly, the need to measure section thickness in order to obtain the disector height/section thickness fraction is challenging since both microcator measurements, microtome block...... advance, and measurements on re-embedded sections are potentially biased. Secondly, disector placement is not uniform random within the section thickness resulting in a bias in most sections with inhomogeneous cell distribution along the z-axis. Re-embedded 2-hydroxyethylmethacrylate (hereafter...... methacrylate) sections were inspected for lost caps to evaluate the possibility of whole section thickness counting with the optical fractionator technique and hippocampal granular cell nucleoli density differences along the z-axis were assessed with a z-axis analysis. No lost caps were found in the examined...

  14. The CAMEO barium release - E/parallel/ fields over the polar cap

    Science.gov (United States)

    Heppner, J. P.; Miller, M. L.; Pongratz, M. B.; Smith, G. M.; Smith, L. L.; Mende, S. B.; Nath, N. R.

    1981-01-01

    Four successive thermite barium releases at an altitude of 965 km over polar cap invariant latitudes 84 to 76 deg near magnetic midnight were conducted from the orbiting second stage of the vehicle that launched Nimbus 7; the releases were made as part of the CAMEO (Chemically Active Material Ejected in Orbit) program. This was the first opportunity to observe the behavior of conventional barium release when conducted at orbital velocity in the near-earth magnetic field. The principal unexpected characteristic in the release dynamics was the high, 1.4 to 2.6 km/s, initial Ba(+) expansion velocity relative to an expected velocity of 0.9 km/s. Attention is also given to neutral cloud expansion, initial ion cloud expansion, convective motion, and the characteristics of field-aligned motion. The possibility of measuring parallel electric fields over the polar cap by observing perturbations in the motion of the visible ions is assessed.

  15. Marine mammal specimen and marine animal sighting data from the USCGC POLAR STAR and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 25 February 1981 to 04 December 1981 (NODC Accession 8300129)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine mammal specimen and marine animal sighting data were collected from the USCGC POLAR STAR and other platforms from 25 February 1981 to 04 December 1981. Data...

  16. Temperature profiles from XBT casts from the SANTA CRUZ and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 01 September 1972 to 05 November 1972 (NODC Accession 7201439)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the SANTA CRUZ and other platforms from 01 September 1972 to 05 November 1972. Data were collected by the...

  17. Temperature profiles from XBT casts from the ENDEAVOR and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 14 January 1979 to 11 July 1979 (NODC Accession 7900211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the ENDEAVOR and other platforms from 14 January 1979 to 11 July 1979. Data were collected by the National...

  18. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 11 May 1982 to 14 August 1982 (NODC Accession 8400075)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 11 May 1982 to 14 August 1982. Data were collected by Envirosphere Co....

  19. Temperature profile and other data from surface sensors and CTD casts from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 04 September 1981 to 14 March 1982 (NODC Accession 8500086)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and other data were collected from surface sensors and CTD casts from aircraft and other platforms from 04 September 1981 to 14 March 1982. Data...

  20. Temperature profile data from surface sensors and CTD casts from the NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 22 October 1981 to 13 October 1982 (NODC Accession 8400037)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected from surface sensors and CTD casts from the NOAA Ship DISCOVERER and other platforms from 22 October 1981 to 13 October...

  1. Physical, meteorological, and other data from surface sensors and CTD casts from the MILLER FREEMAN and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 02 April 1976 to 18 June 1976 (NODC Accession 7601544)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical, meteorological, and other data were collected from surface sensors and CTD casts from the MILLER FREEMAN and other platforms from 02 April 1976 to 18 June...

  2. Pressure gauge and CTD data from ICE ISLANDS and other platforms from the Beaufort and Chukchi Seas in support of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 25 July 1982 to 08 March 1984 (NODC Accession 8500129)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Pressure gauge and CTD data were collected from the ICE ISLANDS and other platforms in the Beaufort and Chukchi Seas from 25 July 1982 to 08 March 1984. Data were...

  3. Feeding flock and other data from ACONA and other platforms from the Bering Sea and other locations as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 04 August 1975 to 16 September 1976 (NODC Accession 7700775)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Feeding flock and other data were collected from the ACONA and other platforms in the Bering Sea and other locations. Data were collected by Oregon State University...

  4. Oceanographic station, meteorological and other data from bottle casts from the MILLER FREEMAN and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 17 September 1969 to 24 August 1972 (NODC Accession 7300185)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic station, meteorological, and other data were collected from bottle casts from the MILLER FREEMAN and other platforms from 17 September 1969 to 24...

  5. Temperature profiles from XBT casts from the DELTA ECUADOR and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 30 September 1978 to 05 October 1978 (NODC Accession 7800858)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the DELTA ECUADOR and other platforms from 30 September 1978 to 05 October 1978. Data were collected by the...

  6. Phytoplankton and other data from net and bottle casts from the NORTHWIND and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 10 September 1970 to 20 May 1979 (NODC Accession 7900338)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Phytoplankton and other data were collected from net and bottle casts from the NORTHWIND and other platforms from 10 September 1970 to 20 May 1979. Data were...

  7. Fish survey, fishing duration, and other data from net trawls from the MILLER FREEMAN and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 03 May 1975 to 04 August 1976 (NODC Accession 7800029)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish survey, fishing duration, and other data were collected from net trawls from the MILLER FREEMAN and other platforms from 03 May 1975 to 04 August 1976. Data...

  8. Marine mammal specimen and other data from the SURVEYOR and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 20 March 1977 to 02 November 1977 (NODC Accession 7900319)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine mammal specimen and other data were collected from the SURVEYOR and other platforms from 20 March 1977 to 02 November 1977. Data were collected by the Alaska...

  9. Temperature profiles from XBT casts from the VALIANT and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 04 March 1979 to 08 April 1979 (NODC Accession 7900186)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the VALIANT and other platforms from 04 March 1979 to 08 April 1979. Data were collected by the National...

  10. Temperature profiles from XBT casts from the VALIANT and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 23 August 1979 to 17 September 1979 (NODC Accession 7900292)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the VALIANT and other platforms from 23 August 1979 to 17 September 1979. Data were collected by the...

  11. Temperature profiles from XBT casts from the VALIANT and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 16 June 1979 to 19 August 1979 (NODC Accession 7900283)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the VALIANT and other platforms from 16 June 1979 to 19 August 1979. Data were collected by the National...

  12. Marine bird sighting and other data from platform as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 04 June 1976 to 24 August 1976 (NODC Accession 7700707)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform from 04 June 1976 to 24 August 1976. Data were collected by the University of Alaska; Institute...

  13. Marine bird sighting and other data from platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 06 June 1977 to 23 September 1977 (NODC Accession 7900213)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms from 06 June 1977 to 23 September 1977. Data were collected by LGL LTD. as part of the Outer...

  14. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 06 March 1975 to 21 March 1976 (NODC Accession 7900039)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms. Data were collected by the Fish and Wildlife Service (FWS) as part of the...

  15. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 09 January 1975 to 09 December 1975 (NODC Accession 7800865)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms. Data were collected by the Fish and Wildlife Service (FWS) as part of the...

  16. Marine bird sighting and other data from platform in the Bering Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 06 May 1976 to 19 August 1976 (NODC Accession 7700132)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform in the Bering Sea from 06 May 1976 to 19 August 1976. Data were collected by the University of...

  17. Marine bird sighting and other data from the DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 05 June 1975 to 20 August 1976 (NODC Accession 7800486)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the DISCOVERER and other platforms. Data were collected as part of the Outer Continental Shelf Environmental...

  18. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 18 June 1975 to 04 April 1976 (NODC Accession 7800721)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms from 18 June 1975 to 04 April 1976. Data were collected by the Fish and...

  19. Marine bird sighting and other data from the BURTON ISLAND and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 30 July 1975 to 12 August 1978 (NODC Accession 7800157)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the BURTON ISLAND and other platforms from 30 July 1975 to 12 August 1978. Data were collected by the Point...

  20. Marine bird sighting and other data from the MILLER FREEMAN and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 08 August 1975 to 23 June 1976 (NODC Accession 7601875)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the MILLER FREEMAN and other platforms from 08 August 1975 to 23 June 1976. Data were collected by Oregon...

  1. Marine bird colony and other data from platforms in the Bering Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 15 June 1975 to 15 October 1976 (NODC Accession 7700654)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird colony and other data were collected from platforms in the Bering Sea from 15 June 1975 to 15 October 1976. Data were collected by the College of the...

  2. Marine bird sighting and other data from the BARGE and other platforms from Beaufort Sea and other locations as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 07 May 1976 to 15 October 1976 (NODC Accession 7800031)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the BARGE and other platforms from the Beaufort Sea and other locations from 07 May 1976 to 15 October 1976....

  3. Marine bird sighting and other data from the DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 12 August 1975 to 06 November 1976 (NODC Accession 7800516)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the DISCOVERER and other platforms from 12 August 1975 to 06 November 1976. Data were collected by Oregon...

  4. Marine bird sighting and other data from the COMMANDO and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 16 May 1978 to 09 September 1978 (NODC Accession 8100584)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the COMMANDO and other platforms from 6 May 1978 to 09 September 1978. Data were collected by the Fish and...

  5. Marine bird sighting and other data from the DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 12 May 1976 to 02 September 1976 (NODC Accession 7601745)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the DISCOVERER and other platforms from 12 May 1976 to 02 September 1976. Data were collected by Oregon...

  6. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 25 April 1978 to 27 September 1978 (NODC Accession 7900210)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms from 25 April 1978 to 27 September 1978. Data were collected by the University...

  7. Marine bird land sighting and other data from platforms from Pribilof Island as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 23 June 1975 to 11 August 1975 (NODC Accession 7601386)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird land sighting and other data were collected from platforms from Pribilof Island from 23 June 1975 to 11 August 1975. Data were collected by the...

  8. Marine bird sighting and other data from the NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 07 July 1977 to 05 June 1981 (NODC Accession 8100693)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the NOAA Ship DISCOVERER and other platforms from 07 July 1977 to 05 June 1981. Data were collected by the...

  9. Marine bird sighting and other data from platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 28 May 1978 to 09 September 1978 (NODC Accession 8100312)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms from 28 May 1978 to 09 September 1978. Data were collected by the University of California (UC) as...

  10. Marine bird sighting and other data from platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 June 1977 to 09 September 1977 (NODC Accession 7900255)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms from 01 June 1977 to 09 September 1977. Data were collected by the University of California (UC)...

  11. Marine bird sighting and other data from the DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 15 April 1976 to 19 August 1976 (NODC Accession 7601827)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the DISCOVERER and other platforms from 15 April 1976 to 19 August 1976. Data were collected by Oregon State...

  12. Marine bird sighting and other data from platform from Kotzebue Sound as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 10 July 1976 to 10 September 1977 (NODC Accession 7900079)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform in the Kotzebue Sound from 10 July 1976 to 10 September 1977. Data were collected by the...

  13. Marine bird sighting and other data from platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 17 June 1976 to 31 August 1976 (NODC Accession 7800255)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms from 17 June 1976 to 31 August 1976. Data were collected by the Alaska State Department of Fish...

  14. Marine bird sighting and other data from the GLACIER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 02 August 1977 to 06 September 1977 (NODC Accession 8100583)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the GLACIER and other platforms from 02 August 1977 to 06 September 1977. Data were collected by the Point...

  15. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 07 March 1977 to 19 September 1977 (NODC Accession 7800158)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms from 07 March 1977 to 19 September 1977. Data were collected by the Alaska...

  16. Marine bird sighting, wind, and other data from the DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 02 July 1975 to 01 September 1978 (NODC Accession 7800821)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting, wind, and other data were collected from the DISCOVERER and other platforms from 02 July 1975 to 01 September 1978. Data were collected by the...

  17. Marine bird sighting and other data from platform as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 08 May 1977 to 18 September 1977 (NODC Accession 7700778)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform from 08 May 1977 to 18 September 1977. Data were collected by the University of Alaska; Institute...

  18. Marine bird sighting and other data from aircraft and other platforms from the Bering Sea and North Pacific as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 09 February 1976 to 01 October 1976 (NODC Accession 7800904)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms in the Bering Sea and North Pacific. Data were collected by the Fish and...

  19. Temperature profiles from XBT casts from the MARINE EVANGELINE and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1981-06-03 to 1981-11-20 (NODC Accession 8100721)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the MARINE EVANGELINE and other platforms from 03 June 1981 to 20 November 1981. Data were collected by the...

  20. Marine bird sighting and other data from platforms in the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 08 June 1976 to 17 September 1976 (NODC Accession 7700308)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms in the Beaufort Sea from 08 June 1976 to 17 September 1976. Data were collected by the University...

  1. Marine bird sighting and other data from platforms in the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 11 June 1975 to 05 September 1975 (NODC Accession 7601518)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms in the Beaufort Sea from 11 June 1975 to 05 September 1975. Data were collected by the University...

  2. Temperature profiles from XBT casts from the DECATUR and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 30 August 1969 to 31 March 1983 (NODC Accession 8300047)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the DECATUR and other platforms from 30 August 1969 to 31 March 1983. Data were collected by the National...

  3. Current and other data from meters attached to fixed platforms in the Gulf of Alaska as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 13 May 1979 to 29 July 1979 (NODC Accession 8000542)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current and other data were collected from meters attached to fixed platforms in the Gulf of Alaska by the University of Alaska - Fairbanks; Institute of Marine...

  4. Zooplankton and other data from net casts from the ACONA and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 02 July 1974 to 15 May 1975 (NODC Accession 7601458)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Zooplankton and other data were collected from net casts from the ACONA and other platforms from 02 July 1974 to 15 May 1975. Data were collected by the University...

  5. Oceanographic station, meteorological and other data from bottle casts from the ALBATROSS IV and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 17 June 1979 to 09 April 1981 (NODC Accession 8100661)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic station, meteorological, and other data were collected from bottle casts from the ALBATROSS IV and other platforms from 17 June 1979 to 09 April 1981....

  6. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 June 1972 to 07 September 1976 (NODC Accession 7700541)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 01 June 1972 to 07 September 1976. Data were collected by the U.S. Fish...

  7. Wind direction and other data from fixed platforms from Point Lay and other locations as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 August 1981 to 30 September 1981 (NODC Accession 8200172)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Wind direction and other data were collected from fixed platforms from Point Lay and other locations from 01 August 1981 to 30 September 1981. Data were collected...

  8. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 21 April 1975 to 05 October 1977 (NODC Accession 7800812)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms from 21 April 1975 to 05 October 1977.. Data were collected by the Fish and...

  9. Physical, meteorological, and other data from surface sensors and CTD casts from the SURVEYOR and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 23 February 1981 to 30 April 1983 (NODC Accession 8300167)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical, meteorological, and other data were collected from surface sensors and CTD casts from the SURVEYOR and other platforms from 23 February 1981 to 30 April...

  10. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 12 May 1975 to 22 August 1975 (NODC Accession 7601354)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 12 May 1975 to 22 August 1975. Data were collected by the Institute of...

  11. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 22 November 1977 to 21 August 1979 (NODC Accession 8000047)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 22 November 1977 to 21 August 1979. Data were collected by the Alaska...

  12. Marine animal sighting and census data from the RESOLUTE and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 15 June 1971 to 29 September 1977 (NCEI Accession 7800682)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from the RESOLUTE and other platforms from 15 June 1971 to 29 September 1977. Data were collected by the...

  13. Temperature profiles from XBT casts from the SANTA CRUZ and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1975-06-22 to 1975-09-17 (NODC Accession 7500932)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the SANTA CRUZ and other platforms from 22 June 1975 to 17 September 1975. Data were collected by Grace...

  14. Drifting buoy and other data from drifting platforms in the Bering Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 17 January 1981 to 20 June 1981 (NODC Accession 8200120)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Drifting buoy data was collected from drifting platforms in the Bering Sea by the Flow Research Company as part of the Outer Continental Shelf Environmental...

  15. Marine toxic substance and other data from bottle casts from NOAA Ship DISCOVERER and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1977-03-22 to 1978-08-18 (NODC Accession 8000246)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from bottle casts from NOAA Ship DISCOVERER and other platforms from 22 March 1977 to 18 August 1978. Data were...

  16. Marine toxic substance and other data from grab casts from the ACONA and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 July 1974 to 31 August 1978 (NODC Accession 8100533)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from grab casts from the ACONA and other platforms from 01 July 1974 to 31 August 1978. Data were collected by...

  17. Marine toxic substance and other data from bottle casts from NOAA Ship DISCOVERER and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1977-11-11 to 1978-08-01 (NODC Accession 7900267)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from bottle casts from NOAA Ship DISCOVERER and other platforms from 11 November 1977 to 01 August 1978. Data...

  18. Marine bird sighting, marine toxic substance, and other data from NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1976-03-25 to 1978-05-02 (NODC Accession 7900171)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting, marine toxic substance, and other data were collected from NOAA Ship DISCOVERER and other platforms from 25 March 1976 to 02 May 1978. Data...

  19. Marine toxic substance and other data from bottle casts from the USCGC GLACIER and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 03 August 1977 to 03 September 1977 (NODC Accession 8000247)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from bottle casts from the USCGC GLACIER and other platforms from 03 August 1977 to 03 September 1977. Data...

  20. Temperature and salinity profiles from CTD casts from the ACONA and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 03 August 1976 to 14 September 1976 (NODC Accession 7601779)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profiles were collected from CTD casts from the ACONA and other platforms from 03 August 1976 to 14 September 1976. Data were collected by...

  1. Temperature profiles from XBT casts from the ALBATROSS IV and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) and WARM CORE RINGS projects from 23 September 1981 to 29 November 1982 (NODC Accession 8200241)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the ALBATROSS IV and other platforms from 23 September 1981 to 29 November 1982. Data were collected by the...

  2. Fish survey, fishing duration, and other data from net trawls from the BARGE and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 30 May 1977 to 13 October 1977 (NODC Accession 7800268)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish survey, fishing duration, and other data were collected from net trawls from the BARGE and other platforms from 30 May 1977 to 13 October 1977. Data were...

  3. Fish survey, fishing duration, and other data from net trawls from the BARGE and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 16 June 1976 to 30 March 1977 (NODC Accession 7800030)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish survey, fishing duration, and other data were collected from net trawls from the BARGE and other platforms from 16 June 1976 to 30 March 1977. Data were...

  4. Fish pathology and other data from NOAA Ship MILLER FREEMAN and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1976-09-02 to 1978-08-27 (NODC Accession 8000026)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish Pathology and other data were collected from NOAA Ship MILLER FREEMAN and other platforms from 02 September 1976 to 27 August 1978. Data were collected by the...

  5. Oceanographic station, meteorological, and other data from bottle casts from the DAN BRAMAN and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 07 May 1971 to 25 August 1971 (NODC Accession 7201264)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic station, meteorological, and other data were collected from bottle casts from the DAN BRAMAN and other platforms from 07 May 1971 to 25 August 1971....

  6. Shelf life of pie caps with biodegradable films as spacers

    OpenAIRE

    Daniela Verónica Escobar Gianni; Angelina Sala; Carlos Silvera; Rodrigo Harispe; Rosa Marquez Romero

    2013-01-01

    Commonly pie caps at market use polyethylene films as spacers between them. This paper studies the conventional spacers replacement with edible and biodegradable films made with whey protein isolate (WPI) and potassium sorbate as a preservative. Besides facilitating the separation of pie caps, with this application is intended to increase their shelf life. The films made by the compression molding method were used as spacers in pie caps without preservative in their formula (A) and with prese...

  7. The catheter hub disinfection cap as esophageal foreign body.

    Science.gov (United States)

    Tawfik, Kareem O; Myer, Charles M; Shikary, Tasneem; Goldschneider, Kenneth R

    2015-12-01

    Disinfection caps are increasingly being used to prevent catheter-associated bloodstream infections. These devices, designed for continuous passive disinfection of catheter hubs, are typically small and often brightly colored. As such, they have the potential to become pediatric airway and esophageal foreign bodies. We report two patients who developed esophageal foreign body following ingestion of disinfection caps. Given the increasing use of these devices, it is imperative that health care providers be aware of this potential iatrogenic problem. We propose that the use of disinfection caps may not be appropriate in pediatric patients with risk factors for foreign body ingestion.

  8. Download - RGP caps | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us RGP caps Download... First of all, please read the license of this database. Data names and data descriptions are about the download...ase. Click the links on Data Name for descriptions of the data. # Data name File Simple search and downloa..._main.zip (18.5 KB) Simple search and download 3 Images of gel electrophoresis rgp_caps_electrophoresis_imag...atabase Description Download License Update History of This Database Site Policy | Contact Us Download - RGP caps | LSDB Archive ...

  9. Biomolecularly capped uniformly sized nanocrystalline materials: glutathione-capped ZnS nanocrystals

    Science.gov (United States)

    Torres-Martínez, Claudia L.; Nguyen, Liem; Kho, Richard; Bae, Weon; Bozhilov, Krassimir; Klimov, Victor; Mehra, Rajesh K.

    1999-09-01

    Micro-organisms such as bacteria and yeasts form CdS to detoxify toxic cadmium ions. Frequently, CdS particles formed in yeasts and bacteria were found to be associated with specific biomolecules. It was later determined that these biomolecules were present at the surface of CdS. This coating caused a restriction in the growth of CdS particles and resulted in the formation of nanometre-sized semiconductors (NCs) that exhibited typical quantum confinement properties. Glutathione and related phytochelatin peptides were shown to be the biomolecules that capped CdS nanocrystallites synthesized by yeasts Candida glabrata and Schizosaccharomyces pombe. Although early studies showed the existence of specific biochemical pathways for the synthesis of biomolecularly capped CdS NCs, these NCs could be formed in vitro under appropriate conditions. We have recently shown that cysteine and cysteine-containing peptides such as glutathione and phytochelatins can be used in vitro to dictate the formation of discrete sizes of CdS and ZnS nanocrystals. We have evolved protocols for the synthesis of ZnS or CdS nanocrystals within a narrow size distribution range. These procedures involve three steps: (1) formation of metallo-complexes of cysteine or cysteine-containing peptides, (2) introduction of stoichiometric amounts of inorganic sulfide into the metallo-complexes to initiate the formation of nanocrystallites and finally (3) size-selective precipitation of NCs with ethanol in the presence of Na+. The resulting NCs were characterized by optical spectroscopy, high-resolution transmission electron microscopy (HRTEM), x-ray diffraction and electron diffraction. HRTEM showed that the diameter of the ZnS-glutathione nanocrystals was 3.45+/-0.5 nm. X-ray diffraction and electron diffraction analyses indicated ZnS-glutathione to be hexagonal. Photocatalytic studies suggest that glutathione-capped ZnS nanocrystals prepared by our procedure are highly efficient in degrading a test model

  10. The evolution of office notes and the electronic medical record: The CAPS note.

    Science.gov (United States)

    Styron, Joseph F; Evans, Peter J

    2016-07-01

    The advent of the electronic medical record (EMR) combined with an expansion of information required by medicolegal and billing departments has transformed the progress note from a succinct note into an often unwieldy data-dump unable to concisely convey the physician's medical reasoning. We describe a new note format--CAPS, which stands for concern, assessment, plan, and supporting data--to streamline the communication of the patient's problem, the practitioner's assessment and plan, and the medical reasoning to support the plan. PMID:27399867

  11. Capítulo I: Contabilidad de costos - Capítulo II : Costos estimados

    OpenAIRE

    Rojas Medina, Ricardo Alfredo

    2014-01-01

    Me permito poner a su consideración los capítulos I y II del libro titulado: Costos un enfoque administrativo y de gerencia, contenido que fue realizado para mejorar y reestructurar el libro titulado Sistemas de costos un proceso para su implementación, que tuvo gran acogida dado el volumen de consulta y descarga del repositorio de la UN. En la primera unidad se trabaja lo referente a costos para la toma de decisiones, presentado un marco teórico y los fundamentos básicos del costeo direct...

  12. PR-PR: Cross-Platform Laboratory Automation System

    Energy Technology Data Exchange (ETDEWEB)

    Linshiz, G; Stawski, N; Goyal, G; Bi, CH; Poust, S; Sharma, M; Mutalik, V; Keasling, JD; Hillson, NJ

    2014-08-01

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  13. PR-PR: cross-platform laboratory automation system.

    Science.gov (United States)

    Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

    2014-08-15

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  14. Identification of Cytoplasmic Capping Targets Reveals a Role for Cap Homeostasis in Translation and mRNA Stability

    Directory of Open Access Journals (Sweden)

    Chandrama Mukherjee

    2012-09-01

    Full Text Available The notion that decapping leads irreversibly to messenger RNA (mRNA decay was contradicted by the identification of capped transcripts missing portions of their 5′ ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study, we used accumulation of uncapped transcripts in cells inhibited for cytoplasmic capping to identify the targets of this pathway. Inhibition of cytoplasmic capping results in the destabilization of some transcripts and the redistribution of others from polysomes to nontranslating messenger ribonucleoproteins, where they accumulate in an uncapped state. Only a portion of the mRNA transcriptome is affected by cytoplasmic capping, and its targets encode proteins involved in nucleotide binding, RNA and protein localization, and the mitotic cell cycle. The 3′ untranslated regions of recapping targets are enriched for AU-rich elements and microRNA binding sites, both of which function in cap-dependent mRNA silencing. These findings identify a cyclical process of decapping and recapping that we term cap homeostasis.

  15. The Geohazards Exploitation Platform

    Science.gov (United States)

    Laur, Henri; Casu, Francesco; Bally, Philippe; Caumont, Hervé; Pinto, Salvatore

    2016-04-01

    The Geohazards Exploitation Platform, or Geohazards TEP (GEP), is an ESA originated R&D activity of the EO ground segment to demonstrate the benefit of new technologies for large scale processing of EO data. This encompasses on-demand processing for specific user needs, systematic processing to address common information needs of the geohazards community, and integration of newly developed processors for scientists and other expert users. The platform supports the geohazards community's objectives as defined in the context of the International Forum on Satellite EO and Geohazards organised by ESA and GEO in Santorini in 2012. The GEP is a follow on to the Supersites Exploitation Platform (SSEP) an ESA initiative to support the Geohazards Supersites & Natural Laboratories initiative (GSNL). Today the GEP allows to exploit 70+ Terabyte of ERS and ENVISAT archive and the Copernicus Sentinel-1 data available on line. The platform has already engaged 22 European early adopters in a validation activity initiated in March 2015. Since September, this validation has reached 29 single user projects. Each project is concerned with either integrating an application, running on demand processing or systematically generating a product collection using an application available in the platform. The users primarily include 15 geoscience centres and universities based in Europe: British Geological Survey (UK), University of Leeds (UK), University College London (UK), ETH University of Zurich (CH), INGV (IT), CNR-IREA and CNR-IRPI (IT), University of L'Aquila (IT), NOA (GR), Univ. Blaise Pascal & CNRS (FR), Ecole Normale Supérieure (FR), ISTERRE / University of Grenoble-Alpes (FR). In addition, there are users from Africa and North America with the University of Rabat (MA) and the University of Miami (US). Furthermore two space agencies and four private companies are involved: the German Space Research Centre DLR (DE), the European Space Agency (ESA), Altamira Information (ES

  16. p-Fitting子群的CAP-嵌入子群%On CAP-Embedded Subgroups of p-Fitting Subgroups

    Institute of Scientific and Technical Information of China (English)

    郭鹏飞; 郭秀云

    2010-01-01

    群G的子群H称为G的CAP-嵌入子群,如果对于|H|的每个素因子p,存在G的某个CAP-子群K,使得H的某个Sylow p-子群也是K的一个Sylowp-子群.本文通过假定G的p-Fitting子群Fp(G)的某个Sylow p-子群的每个极大子群是G的CAP-嵌入子群,得到一些新的结果.

  17. Promoting Assessment Efficacy through an Integrated System for Online Clinical Assessment of Practical Skills

    Science.gov (United States)

    Hay, Peter J.; Engstrom, Craig; Green, Anita; Friis, Peter; Dickens, Sue; Macdonald, Doune

    2013-01-01

    This paper presents evaluation outcomes from an externally funded research project involving the online clinical assessment of practical skills (eCAPS) using web-based video technologies within a university medical programme. eCAPS was implemented to trial this web-based approach for promoting the efficacy of "practical" skills assessment in knee…

  18. NON AUTOMATICALLY EXERCISED (NAE EUROPEAN CAPPED CALL PRICING THEORY

    Directory of Open Access Journals (Sweden)

    Subanar .

    2012-07-01

    Full Text Available The objective of this paper is to present a methodology for deriving Black Scholes formulae via a simple lognormal distribution approach and introduce European capped non automatically exercise (NAE call option pricing theory.

  19. C-CAP Land Cover, Territory of Guam 2005

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  20. ATLAS - End-Cap calorimeter lowered in to the cavern

    CERN Multimedia

    2006-01-01

    The End-cap calorimeter was lowered into the ATLAS cavern at POINT1. This calorimeter will measure the energy of particles close to the beam axis when protons collide. Cooling is important for maximum detector efficiency.

  1. C-CAP Land Cover, Big Island, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  2. C-CAP Land Cover, Territory of Guam 2011

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  3. 2011 C-CAP Land Cover of Oahu, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  4. Rationale and design of the Baptist Employee Healthy Heart Study: a randomized trial assessing the efficacy of the addition of an interactive, personalized, web-based, lifestyle intervention tool to an existing health information web platform in a high-risk employee population

    OpenAIRE

    Post, Janisse M.; Ali, Shozab S.; Roberson, Lara L.; Ehimen C Aneni; Shaharyar, Sameer; Younus, Adnan; Jamal, Omar; Ahmad, Rameez; Aziz, Muhammad A.; Malik, Rehan; Spatz, Erica S.; Feldman, Theodore; Fialkow, Jonathan; Veledar, Emir; Ricardo C Cury

    2016-01-01

    Background Metabolic syndrome (MetS) and diabetes confer a high risk for developing subsequent cardiovascular disease (CVD). Persons with MetS constitute 24–34 % of the employee population at Baptist Health South Florida (BHSF), a self-insured healthcare organization. The Baptist Employee Healthy Heart Study (BEHHS) aims to assess the addition of a personalized, interactive, web-based, nutrition-management and lifestyle-management program to the existing health-expertise web platform availabl...

  5. Rat as a model for direct pulp capping research

    OpenAIRE

    Orhan, Ekim Onur

    2013-01-01

    The aim of this review is to evaluate the suitability of rat teeth in preclinical evaluation of medical materials for direct pulp capping. The international standard states clearly that only non-rodent mammals are suitable species for animal research in dentistry. However, in the past halve of the century many research have been published using rat teeth in order to evaluate direct pulp capping, pulpotomies and tissue reactions after pulp exposure. Numerous studies showed that the healing of ...

  6. A regional analysis of CAP expenditure in Austria

    OpenAIRE

    Strahl, Wibke; Dax, Thomas; Hovorka, Gerhard

    2011-01-01

    This paper reflects the demand for taking account of the territorial dimension in the application of Common Agricultural Policy (CAP) more comprehensively. While this has been addressed in rural development discourse to a wide extent over the last two decades and consensus for regionalized strategies is emerging, programme evaluation is in general still limited to the analysis of policy interventions at the national level. This implies that conclusions on the territorial effects of CAP are la...

  7. Viral Agents Causing Brown Cap Mushroom Disease of Agaricus bisporus

    OpenAIRE

    Eastwood, Daniel; Green, Julian; Grogan, Helen; Burton, Kerry

    2015-01-01

    The symptoms of viral infections of fungi range from cryptic to severe, but there is little knowledge of the factors involved in this transition of fungal/viral interactions. Brown cap mushroom disease of the cultivated Agaricus bisporus is economically important and represents a model system to describe this transition. Differentially expressed transcript fragments between mushrooms showing the symptoms of brown cap mushroom disease and control white noninfected mushrooms have been identifie...

  8. Effect of Swim Cap Surface Roughness on Passive Drag.

    Science.gov (United States)

    Gatta, Giorgio; Cortesi, Matteo; Zamparo, Paola

    2015-11-01

    In the last decade, great attention has been given to the improvements in swimming performance that can be obtained by wearing "technical swimsuits"; the technological evolution of these materials only marginally involved swim caps production, even if several studies have pointed out the important role of the head (as main impact point with the fluid) on hydrodynamics. The aim of this study was to compare the effects on passive drag (Dp) of 3 swim cap models: a smooth silicon helmet cap (usually used during swimming competitions), a silicon helmet cap with "dimples," and a silicon helmet cap with "wrinkles." Experiments were performed on 10 swimmers who were towed underwater (at a depth of 60 cm) at 3 speeds (1.5, 1.7, and 1.9 m·s) and in 2 body positions: LA (arms above the swimmer's head) and SA (arms alongside the body). The Dp values obtained in each trial were divided by the square of the corresponding speed to obtain the speed-specific drag (the k coefficient = Dp/v). No differences in k were observed among swim caps in the LA position. No differences in k were observed between the smooth and dimpled helmets also in the SA position; however, the wrinkled swim cap helmet showed a significant larger k (4.4%) in comparison with the model with dimples, when the swimmers kept their arms alongside the body (in the SA position). These data suggest that wearing a wrinkled swim cap helmet can be detrimental to performance at least in this specific position.

  9. Mid-small Cap Vs. Heavy-weight Share

    Institute of Scientific and Technical Information of China (English)

    Liu Xinwen

    2008-01-01

    @@ In light of the current investment trends,mid and small cap stocks are the stocks of choice for institutional capital.Currently,101 listed companies have released their performance reports.Repots show that increased stocks from 55 companies are held by institutions,some heavy-weight blue-chip stocks were sold with large margins,while some mid and small cap stocks were widely welcomed by investors.

  10. Density functional study of condensation in capped capillaries

    Science.gov (United States)

    Yatsyshin, P.; Savva, N.; Kalliadasis, S.

    2015-07-01

    We study liquid adsorption in narrow rectangular capped capillaries formed by capping two parallel planar walls (a slit pore) with a third wall orthogonal to the two planar walls. The most important transition in confined fluids is arguably condensation, where the pore becomes filled with the liquid phase which is metastable in the bulk. Depending on the temperature T, the condensation in capped capillaries can be first-order (at T≤slant {{T}\\text{cw}} ) or continuous (at T\\gt {{T}\\text{cw}} ), where {{T}\\text{cw}} is the capillary wetting temperature. At T \\gt {{T}\\text{cw}} , the capping wall can adsorb mesoscopic amounts of metastable under-condensed liquid. The onset of condensation is then manifested by the continuous unbinding of the interface between the liquid adsorbed on the capping wall and the gas filling the rest of the capillary volume. In wide capped capillaries there may be a remnant of wedge filling transition, which is manifested by the adsorption of liquid drops in the corners. Our classical statistical mechanical treatment predicts a possibility of three-phase coexistence between gas, corner drops and liquid slabs adsorbed on the capping wall. In sufficiently wide capillaries we find that thick prewetting films of finite length may be nucleated at the capping wall below the boundary of the prewetting transition. Prewetting then proceeds in a continuous manner manifested by the unbinding interface between the thick and thin films adsorbed on the side walls. Our analysis is based on a detailed numerical investigation of the density functional theory for the fluid equilibria for a number of illustrative case studies.

  11. Novel Multipin Electrode Cap System for Dry Electroencephalography.

    Science.gov (United States)

    Fiedler, P; Pedrosa, P; Griebel, S; Fonseca, C; Vaz, F; Supriyanto, E; Zanow, F; Haueisen, J

    2015-09-01

    Current usage of electroencephalography (EEG) is limited to laboratory environments. Self-application of a multichannel wet EEG caps is practically impossible, since the application of state-of-the-art wet EEG sensors requires trained laboratory staff. We propose a novel EEG cap system with multipin dry electrodes overcoming this problem. We describe the design of a novel 24-pin dry electrode made from polyurethane and coated with Ag/AgCl. A textile cap system holds 97 of these dry electrodes. An EEG study with 20 volunteers compares the 97-channel dry EEG cap with a conventional 128-channel wet EEG cap for resting state EEG, alpha activity, eye blink artifacts and checkerboard pattern reversal visual evoked potentials. All volunteers report a good cap fit and good wearing comfort. Average impedances are below 150 kΩ for 92 out of 97 dry electrodes, enabling recording with standard EEG amplifiers. No significant differences are observed between wet and dry power spectral densities for all EEG bands. No significant differences are observed between the wet and dry global field power time courses of visual evoked potentials. The 2D interpolated topographic maps show significant differences of 3.52 and 0.44% of the map areas for the N75 and N145 VEP components, respectively. For the P100 component, no significant differences are observed. Dry multipin electrodes integrated in a textile EEG cap overcome the principle limitations of wet electrodes, allow rapid application of EEG multichannel caps by non-trained persons, and thus enable new fields of application for multichannel EEG acquisition.

  12. ASM LabCap's contributions to disease surveillance and the International Health Regulations (2005).

    Science.gov (United States)

    Specter, Steven; Schuermann, Lily; Hakiruwizera, Celestin; Sow, Mah-Séré Keita

    2010-01-01

    The revised International Health Regulations [IHR(2005)], which requires the Member States of the World Health Organization (WHO) to develop core capacities to detect, assess, report, and respond to public health threats, is bringing new challenges for national and international surveillance systems. As more countries move toward implementation and/or strengthening of their infectious disease surveillance programs, the strengthening of clinical microbiology laboratories becomes increasingly important because they serve as the first line responders to detect new and emerging microbial threats, re-emerging infectious diseases, the spread of antibiotic resistance, and the possibility of bioterrorism. In fact, IHR(2005) Core Capacity #8, "Laboratory", requires that laboratory services be a part of every phase of alert and response.Public health laboratories in many resource-constrained countries require financial and technical assistance to build their capacity. In recognition of this, in 2006, the American Society for Microbiology (ASM) established an International Laboratory Capacity Building Program, LabCap, housed under the ASM International Board. ASM LabCap utilizes ASM's vast resources and its membership's expertise-40,000 microbiologists worldwide-to strengthen clinical and public health laboratory systems in low and low-middle income countries. ASM LabCap's program activities align with HR(2005) by building the capability of resource-constrained countries to develop quality-assured, laboratory-based information which is critical to disease surveillance and the rapid detection of disease outbreaks, whether they stem from natural, deliberate or accidental causes.ASM LabCap helps build laboratory capacity under a cooperative agreement with the U.S. Centers for Disease Control and Prevention (CDC) and under a sub-contract with the Program for Appropriate Technology in Health (PATH) funded by the United States Agency for International Development (USAID

  13. A decision tool for selecting trench cap designs

    Energy Technology Data Exchange (ETDEWEB)

    Paige, G.B.; Stone, J.J.; Lane, L.J. [USDA-ARS, Tucson, AZ (United States)] [and others

    1995-12-31

    A computer based prototype decision support system (PDSS) is being developed to assist the risk manager in selecting an appropriate trench cap design for waste disposal sites. The selection of the {open_quote}best{close_quote} design among feasible alternatives requires consideration of multiple and often conflicting objectives. The methodology used in the selection process consists of: selecting and parameterizing decision variables using data, simulation models, or expert opinion; selecting feasible trench cap design alternatives; ordering the decision variables and ranking the design alternatives. The decision model is based on multi-objective decision theory and uses a unique approach to order the decision variables and rank the design alternatives. Trench cap designs are evaluated based on federal regulations, hydrologic performance, cover stability and cost. Four trench cap designs, which were monitored for a four year period at Hill Air Force Base in Utah, are used to demonstrate the application of the PDSS and evaluate the results of the decision model. The results of the PDSS, using both data and simulations, illustrate the relative advantages of each of the cap designs and which cap is the {open_quotes}best{close_quotes} alternative for a given set of criteria and a particular importance order of those decision criteria.

  14. Response of northern winter polar cap to auroral substorms

    Science.gov (United States)

    Liou, Kan; Sotirelis, Thomas

    2016-05-01

    The three-phase substorm sequence has been generally accepted and is often tied to the Dungey cycle. Although previous studies have mostly agreed on the increase and decrease in the polar cap area during an episode of substorm, there are disparate views on when the polar cap starts to contract relative to substorm onset. Here we address this conflict using high-resolution (~1-3 min) snapshot global auroral images from the ultraviolet imager on board the Polar spacecraft. On the basis of 28 auroral substorm events, all observed in the Northern Hemispheric winter, it is found that the polar cap inflated prior to onset in all events and it attained the largest area ~6 min prior to the substorm expansion phase onset, while the dayside polar cap area remained steady around the onset. The onset of nightside polar cap deflation is found to be attributed to intensifications of aurora on the poleward edge of the nightside oval, mostly in the midnight sector. Although this result supports the loading-unloading and reconnection substorm models, it is not clear if the initial polar cap deflation and the substorm expansion are parts of the same process.

  15. Myc Regulation of mRNA Cap Methylation

    Science.gov (United States)

    Cowling, Victoria H.; Cole, Michael D.

    2010-01-01

    The c-myc proto-oncogene regulates the expression of 15% to 20% of all genes, depending on the cell type, and the regulation is usually modest (1.5- to 2.0-fold). The authors discovered that in addition to regulating mRNA abundance, c-Myc regulates the formation of the 7-methylguanosine cap on many mRNAs, including transcriptional target genes and others not transcriptionally activated. Because the 7-methylguanosine cap is required for effective translation, enhanced methyl cap formation leads to increased protein production from Myc-responsive genes that exceeds the transcriptional induction. Increased cap methylation is linked to Myc-dependent enhanced activity of 2 critical kinases, TFIIH and p-TEFb, which phosphorylate the RNA polymerase II carboxy-terminal domain (CTD). Phosphorylation of the CTD recruits RNGTT and RNMT, the enzymes involved in mRNA capping, to the nascent transcript. Evidence is accumulating that enhanced cap methylation makes a significant contribution to Myc-dependent gene regulation and protein production. PMID:21170289

  16. ALICE Connex : Mobile Volunteer Computing and Edutainment Platform

    CERN Document Server

    Chalumporn, Gantaphon

    2016-01-01

    Mobile devices are very powerful and trend to be developed. They have functions that are used in everyday life. One of their main tasks is to be an entertainment devices or gaming platform. A lot of technologies are now accepted and adopted to improve the potential of education. Edutainment is a combination of entertainment and education media together to make use of both benefits. In this work, we introduce a design of edutainment platform which is a part of mobile volunteer computing and edutainment platform called ‘ALICE Connex’ for ALICE at CERN. The edutainment platform focuses to deliver enjoyment and education, while promotes ALICE and Volunteer Computing platform to general public. The design in this work describes the functionality to build an effective edutainment with real-time multiplayer interaction on round-based gameplay, while integrates seamless edutainment with basic particle physic content though game mechanism and items design. For the assessment method we will observe the enjoyment o...

  17. Vertical Wave Impacts on Offshore Wind Turbine Inspection Platforms

    DEFF Research Database (Denmark)

    Bredmose, Henrik; Jacobsen, Niels Gjøl

    2011-01-01

    on a horizontal inspection platform is computed for five different platform levels. The computational results show details of monopile impact such as slamming pressures from the overturning wave front and the formation of run-up flow. The results show that vertical platform impacts can occur at 20 m water depth......Breaking wave impacts on a monopile at 20 m depth are computed with a VOF (Volume Of Fluid) method. The impacting waves are generated by the second-order focused wave group technique, to obtain waves that break at the position of the monopile. The subsequent impact from the vertical run-up flow....... The dependence of the vertical platform load to the platform level is discussed. Attention is given to the significant downward force that occur after the upward force associated with the vertical impact. The effect of the numerical resolution on the results is assessed. The position of wave overturning is found...

  18. INTERACTION OF A LONG PILE OF FINITE STIFFNESS WITH SURROUNDING SOIL AND FOUNDATION CAP

    Directory of Open Access Journals (Sweden)

    Ter-Martirosyan Zaven Grigor’evich

    2015-09-01

    Full Text Available The article presents the formulation and analytical solution to a quantification of stress strain state of a two-layer soil cylinder enclosing a long pile, interacting with the cap. The solution of the problem is considered for two cases: with and without account for the settlement of the heel and the underlying soil. In the first case, the article is offering equations for determining the stresses of pile’s body and the surrounding soil according to their hardness and the ratio of radiuses of the pile and the surrounding soil cylinder, as well as formulating for determining equivalent deformation modulus of the system “cap-pile-surrounding soil” (the system. Assessing the carrying capacity of the soil under pile’s heel is of great necessity. In the second case, the article is solving a second-order differential equation. We gave the formulas for determining the stresses of the pile at its top and heel, as well as the variation of stresses along the pile’s body. The article is also formulating for determining the settlement of the foundation cap and equivalent deformation modulus of the system. It is shown that, pushing the pile into underlying layer results in the reducing of equivalent modulus of the system.

  19. Rhapsody on small processor platforms

    OpenAIRE

    Andersson, Per-Oskar

    2008-01-01

    Rhapsody is a Model-Driven Development (MDD) tool for embedded and real-time system design. The purpose of this thesis is to determine if Rhapsody can be used for software development on small processor platforms such as the Atmel AVR. Rhapsody is normally used on platforms running an operating system. Therefore certain adaptations are needed in order to use it on platforms without an operating system. These adaptations and their affect on the usability of the tool, advantages and disadvantag...

  20. Utilizing platforms in industrialized construction

    DEFF Research Database (Denmark)

    Bonev, Martin; Wörösch, Michael; Hvam, Lars

    2015-01-01

    construction companies. A promising approach adapted by operations management and design theory regards individual building projects as the adjustment and recombination of components and processes from a set of predefined platforms, while configuration systems assure feasible building solutions. Design...... methods map structural platform characteristics so as to balance commonality and distinctiveness. Originality/value – This paper proposes a general theory of platform-based development and execution in the industrialised construction sector, which goes beyond concurrent approaches of standardising...

  1. Communications payloads for geostationary platforms

    Science.gov (United States)

    Fordyce, S. W.

    1978-01-01

    Trends in communication satellites show increasing reuse of the frequency spectrum through multiple spot beams and orthogonal polarization, as well as consortia operation. Current reliance on orbital arc separation for frequency reuse may be inadequate for the projected traffic growth and the orbital slotting proposals before the ITU. This paper notes that cost advantages can accrue through common use of spacecraft subsystems and multiple users' platforms aboard a common geostationary platform. The rationale for such platforms is described and potential payloads are suggested.

  2. Web Platform Application

    Energy Technology Data Exchange (ETDEWEB)

    Paulsworth, Ashley [Sunvestment Group, Frederick, MD (United States); Kurtz, Jim [Sunvestment Group, Frederick, MD (United States); Brun de Pontet, Stephanie [Sunvestment Group, Frederick, MD (United States)

    2016-06-15

    Sunvestment Energy Group (previously called Sunvestment Group) was established to create a web application that brings together site hosts, those who will obtain the energy from the solar array, with project developers and funders, including affinity investors. Sunvestment Energy Group (SEG) uses a community-based model that engages with investors who have some affinity with the site host organization. In addition to a financial return, these investors receive non-financial value from their investments and are therefore willing to offer lower cost capital. This enables the site host to enjoy more savings from solar through these less expensive Community Power Purchase Agreements (CPPAs). The purpose of this award was to develop an online platform to bring site hosts and investors together virtually.

  3. Energy Tracking Software Platform

    Energy Technology Data Exchange (ETDEWEB)

    Ryan Davis; Nathan Bird; Rebecca Birx; Hal Knowles

    2011-04-04

    Acceleration has created an interactive energy tracking and visualization platform that supports decreasing electric, water, and gas usage. Homeowners have access to tools that allow them to gauge their use and track progress toward a smaller energy footprint. Real estate agents have access to consumption data, allowing for sharing a comparison with potential home buyers. Home builders have the opportunity to compare their neighborhood's energy efficiency with competitors. Home energy raters have a tool for gauging the progress of their clients after efficiency changes. And, social groups are able to help encourage members to reduce their energy bills and help their environment. EnergyIT.com is the business umbrella for all energy tracking solutions and is designed to provide information about our energy tracking software and promote sales. CompareAndConserve.com (Gainesville-Green.com) helps homeowners conserve energy through education and competition. ToolsForTenants.com helps renters factor energy usage into their housing decisions.

  4. Reproducible Experiment Platform

    CERN Document Server

    Likhomanenko, Tatiana; Baranov, Alexander; Khairullin, Egor; Ustyuzhanin, Andrey

    2015-01-01

    Data analysis in fundamental sciences nowadays is an essential process that pushes frontiers of our knowledge and leads to new discoveries. At the same time we can see that complexity of those analyses increases fast due to a)~enormous volumes of datasets being analyzed, b)~variety of techniques and algorithms one have to check inside a single analysis, c)~distributed nature of research teams that requires special communication media for knowledge and information exchange between individual researchers. There is a lot of resemblance between techniques and problems arising in the areas of industrial information retrieval and particle physics. To address those problems we propose Reproducible Experiment Platform (REP), a software infrastructure to support collaborative ecosystem for computational science. It is a Python based solution for research teams that allows running computational experiments on shared datasets, obtaining repeatable results, and consistent comparisons of the obtained results. We present s...

  5. An add-on cap for ATR-IR spectroscopy studies

    DEFF Research Database (Denmark)

    2014-01-01

    The invention relates to a cap (300B) for an attenuated total reflectance infrared (ATR-IR) spectrometer, the ATR-IR spectrometer comprising an ATR-IR plate (200). The cap (300B) comprises an ATR- IR plate facing cap surface. When the ATR-IR plate facing cap surface is placed on the sample surfac...

  6. 22 CFR 121.11 - Military demolition blocks and blasting caps.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Military demolition blocks and blasting caps... blasting caps. Military demolition blocks and blasting caps referred to in Category IV(a) do not include the following articles: (a) Electric squibs. (b) No. 6 and No. 8 blasting caps, including...

  7. Power Quality Indices Estimation Platform

    Directory of Open Access Journals (Sweden)

    Eliana I. Arango-Zuluaga

    2013-11-01

    Full Text Available An interactive platform for estimating the quality indices in single phase electric power systems is presented. It meets the IEEE 1459-2010 standard recommendations. The platform was developed in order to support teaching and research activities in electric power quality. The platform estimates the power quality indices from voltage and current signals using three different algorithms based on fast Fourier transform (FFT, wavelet packet transform (WPT and least squares method. The results show that the algorithms implemented are efficient for estimating the quality indices of the power and the platform can be used according to the objectives established. 

  8. Platform decisions supported by gaming

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    be described as being a configuration problem with a high number of variables. These variables are different in nature; they have contradictory influence on the total performance, and, their importance change over time. Consequently, the specific platform decisions become highly complex and the consequences...... support to the platform decision making.......Platform is an ambiguous multidisciplinary concept. The philosophy behind it is easy to communicate and makes intuitively sense. However, the ease in communication does overshadow the high complexity when the concept is implemented. The practical industrial platform implementation challenge can...

  9. ICP (ITER Collaborative Platform)

    International Nuclear Information System (INIS)

    The ITER organization has the necessity to manage a massive amount of data and processes. Each team requires different process and databases often interconnected with those of others teams. ICP (ITER Collaborative Platform) is the current central ITER repository of structured and unstructured data. All data in ICP is served and managed via a web interface that provides global accessibility with a common user friendly interface. This paper will explain the model used by ICP and how it serves the ITER project by providing a robust and agile platform. ICP is developed in ASP.NET using MSSQL Server for data storage. It currently houses 15 data driven applications, 150 different types of record, 500 k objects and 2.5 M references. During European working hours the system averages 150 concurrent users and 20 requests per second. ICP connects to external database applications to provide a single entry point to ITER data and a safe shared storage place to maintain this data long-term. The Core model provides an easy to extend framework to meet the future needs of the Organization. ICP follows a multi-tier architecture, providing logical separation of process. The standard three-tier architecture is expanded, with the data layer separated into data storage, data structure, and data access components. The business or applications logic layer is broken up into a common business functionality layer, a type specific logic layer, and a detached work-flow layer. Finally the presentation tier comprises a presentation adapter layer and an interface layer. Each layer is built up from small blocks which can be combined to create a wide range of more complex functionality. Each new object type developed gains access to a wealth of existing code functionality, while also free to adapt and extend this. The hardware structure is designed to provide complete redundancy, high availability and to handle high load. This document is made of the slides of the presentation. (authors)

  10. Clayey cap-rocks reactivity in presence of CO2 in deep geological storage conditions: experimentation/modeling integrated approach

    International Nuclear Information System (INIS)

    CO2 capture, transport and geological storage is one of the main solutions considered in the short and medium term to reduce CO2 and others greenhouse gases emissions towards the atmosphere, by storing CO2 in deeper geological reservoirs during 100 to 10 000 years. This Ph-D study offers a multi-scale vision of complex clayey cap-rocks reactivity and evolution. These formations are identified for the CO2 containment and sealing into the reservoir. From the experimental scale on purified clay minerals to integrative modeling at high space and time scales, the strategy developed allowed identifying the main geochemical processes, to check the good agreement between experiment and modeling, and to lay emphasis the operational impacts on long-term cap-rocks integrity. Carbonated cements alteration is likely to open cap-rock porosity and to create preferential reactive pathway for reactive fluid flow. Besides, this could alter the cap-rock structure and the global geo-mechanic properties. Clay minerals alteration, including the illitization process, reduces the clay fraction volume but considerably limits the porosity increase. The illitization process in acidic conditions determined experimentally and by modeling at low and high scale, is coupled with silica precipitation. The final porosity increase control results of these two reactive processes balance. By a fundamental side, this study reveals new kinetic parameters of clay minerals and highlights new structural transformations. By an operational side, this study contributes to the acquisition of qualitative data (long-term reactive pathways of clayey cap-rocks, coupled reactivity carbonates/clays) and quantitative data (CO2 penetration distance into the cap-rock) to partly answer to the performance and safety assessment CO2 capture and geological storage. (author)

  11. CAPS-POEIRA: um modo de intervenção no CAPS-ad

    Directory of Open Access Journals (Sweden)

    Natália Galdiano Vieira de Matos

    2011-01-01

    Full Text Available Este trabajo versa sobre el reducto de las experiencias de la investigadora conforme la voluntaria de "Capoeira Angola" en una unidad CAPS-ad. Transitando por la posición de voluntaria y psicóloga se buscó comprender la dinámica de los sujetos usuarios del servicio, además de nombrar los sentidos proporcionados por el encuentro entre el Psicoanálisis y la Capoeira Angola en los grupos operativos del CAPS-ad, siendo éste el objetivo general delineado en el trabajo. En aquel escenario, en que muchos sujetos usuarios del servicio estaban absortos a la droga, había aquellos que se interesaban por los talleres y demostraban atención a los propios tratamientos. La propuesta era comprender la dinámica observada en el grupo de sujetos drogadictos y provocar inquietudes posibles. Para eso, se intensificaba el entrelazamiento entre el Psicoanálisis, la Capoeira Angola y los grupos operativos, recursos que proporcionaban una mayor aproximación a la psique humana, el reconocimiento de la potencialidad humana de creación y de transformación de la realidad, y la comprensión de que en los grupos podría haber una re-significación de las vivencias personales y grupales. Fueron desarrollados once encuentros cuya propuesta era la articulación de los grupos con los recursos de la Capoeira Angola-musica, narrativa y movimiento. La conclusión presenta la complejidad de la problemática droga y el posible movimiento provocado en aquel grupo por medio de la Capoeira Angola, arte ancestral marcada por la resistencia en la sociedad contemporánea.

  12. The capping domain in RalF regulates effector functions.

    Directory of Open Access Journals (Sweden)

    Eric Alix

    Full Text Available The Legionella pneumophila effector protein RalF functions as a guanine nucleotide exchange factor (GEF that activates the host small GTPase protein ADP-ribosylation factor (Arf, and recruits this host protein to the vacuoles in which this pathogen resides. GEF activity is conferred by the Sec7 domain located in the N-terminal region of RalF. Structural studies indicate that the C-terminal region of RalF makes contacts with residues in the Sec7 domain important for Arf interactions. Theoretically, the C-terminal region of RalF could prevent nucleotide exchange activity by blocking the ability of Arf to interact with the Sec7 domain. For this reason, the C-terminal region of RalF has been termed a capping domain. Here, the role of the RalF capping domain was investigated by comparing biochemical and effector activities mediated by this domain in both the Legionella RalF protein (LpRalF and in a RalF ortholog isolated from the unrelated intracellular pathogen Rickettsia prowazekii (RpRalF. These data indicate that both RalF proteins contain a functional Sec7 domain and that the capping domain regulates RalF GEF activity. The capping domain has intrinsic determinants that mediate localization of the RalF protein inside of host cells and confer distinct effector activities. Localization mediated by the capping domain of LpRalF enables the GEF to modulate membrane transport in the secretory pathway, whereas, the capping domain of RpRalF enables this bacterial GEF to modulate actin dynamics occurring near the plasma membrane. Thus, these data reveal that divergence in the function of the C-terminal capping domain alters the in vivo functions of the RalF proteins.

  13. The transmission link of CAPS navigation and communication system

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The Chinese Area Positioning System (CAPS) is based on communication satellites with integrated capability, which is different from the Global Positioning System (GPS), the International Maritime Satellite Organization (Inmarsat) and so on. CAPS works at C-band, and its navigation information is not directly generated from the satellite, but from the master control station on the ground and transmitted to users via the satellite. The slightly inclined geostationary-satellite orbit (SIGSO) satellites are adopted in CAPS. All of these increase the difficulty in the design of the system and terminals. In this paper, the authors study the CAPS configuration parameters of the navigation master control station, information transmission capability, and the selection of the antenna aperture of the communication center station, as well as the impact of satellite parameters on the whole communication system from the perspective of the transmission link budget. The conclusion of availability of the CAPS navigation system is achieved. The results show that the CAPS inbound communication system forms a new low-data-rate satellite communication system, which can accommodate mass communication terminals with the transmission rate of no more than 1 kbps for every terminal. The communication center station should be configured with a large-aperture antenna (about 10-15 m); spread spectrum com- munication technology should be used with the spreading gain as high as about 40 dB; reduction of the satellite transponder gain attenuation is beneficial to improving the signal-to-noise ratio of the system, with the attenuation value of 0 or 2 dB as the best choice. The fact that the CAPS navigation system has been checked and accepted by the experts and the operation is stable till now clarifies the rationality of the analysis results. The fact that a variety of experiments and applications of the satellite communication system designed according to the findings in this paper have been

  14. Identifying Influential Scholars in Academic Social Media Platforms

    OpenAIRE

    Li N; Gillet D.

    2013-01-01

    The emergence of social media has created new ways to publish scientific work, foster collaboration, and build professional connections in the research community. The rich data collected in social media platforms has provided new opportunities for assessing scholars' impact other than the traditional citation-based approach. In this paper, we investigate the measures of scholars' influence in academic social media platforms, taking both academic and social impact into account. A real-life dat...

  15. The "demand side" effect of price caps: uncertainty, imperfect competition, and ration

    OpenAIRE

    Léautier, Thomas-Olivier

    2014-01-01

    Price caps are often used by policy makers to "regulate markets". Previous analyses have focussed on the "supply side" impact of these caps, and derived the optimal price cap, which maximizes investment and welfare. This article expands the analysis to include the "demand side" impact of price caps: when prices can no longer rise, customers must be rationed to adjust demand to available supply. This yields two new findings, that contradict previous analyses. First, the welfare-maximizing cap ...

  16. A Typology of Multi-sided Platforms

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2015-01-01

    In this paper we address how the composition of a platform impacts the platform’s business model. By platform’s business model we mean platform features, platform architecture and platform governance. To this end, we construct the Platform Business Model Framework. We apply the framework to three...... in several configurations. The particular platform architecture can explain the difficulties in designing a viable business models for platforms....

  17. Solid state synthesis of starch-capped silver nanoparticles.

    Science.gov (United States)

    Hebeish, A; Shaheen, Th I; El-Naggar, Mehrez E

    2016-06-01

    The present research addresses the establishment of a technique which is solely devoted to environmentally friendly one-pot green synthesis of dry highly stable powdered silver nanoparticles (AgNPs) using starch as both reductant and stabilizing agent in the presence of sodium hydroxide. It is believed that the sodium hydroxide can improve the reduction potential of starch. Thus when the alkali treated starch is submitted to addition of silver nitrate (AgNO3), the alkali treated starch induces the well-established dual role of starch; reduction of silver ions (Ag(+)) to AgNPs and capping the as-formed AgNPs to prevent them from further growth and agglomeration. Beside assessment of AgNPs formation, structural and morphological characteristics of AgNPs are investigated by making use of UV-vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, FT-IR and X-ray diffraction (XRD) analysis. Research outputs signify (a) the absorbance around 410-420nm in the UV-vis spectra of AgNPs appears most, probably owing to the presence of nanosized silver particles and the intensity of this peak increases by increasing AgNO3 concentration; (b) that highly stable AgNPs with well-dispersed particle are successfully prepared using the present research-based innovation; (c) that the size of AgNPs does not exceed 30nm with sphere-like morphology even at the highest Ag(+) concentration employed during synthesis operation; (d) that the XRD and FT-IR confirm the successful preparation of pure AgNPs without noticeable impurities; (d) and that the one-pot synthesis of powdered AgNPs in large scale is clean and easily operated and easily transportation which may be applied as per demands of industries such as textile and painting industry. PMID:26902893

  18. Hen's teeth with enamel cap: from dream to impossibility

    Directory of Open Access Journals (Sweden)

    Girondot Marc

    2008-09-01

    Full Text Available Abstract Background The ability to form teeth was lost in an ancestor of all modern birds, approximately 100-80 million years ago. However, experiments in chicken have revealed that the oral epithelium can respond to inductive signals from mouse mesenchyme, leading to reactivation of the odontogenic pathway. Recently, tooth germs similar to crocodile rudimentary teeth were found in a chicken mutant. These "chicken teeth" did not develop further, but the question remains whether functional teeth with enamel cap would have been obtained if the experiments had been carried out over a longer time period or if the chicken mutants had survived. The next odontogenetic step would have been tooth differentiation, involving deposition of dental proteins. Results Using bioinformatics, we assessed the fate of the four dental proteins thought to be specific to enamel (amelogenin, AMEL; ameloblastin, AMBN; enamelin, ENAM and to dentin (dentin sialophosphoprotein, DSPP in the chicken genome. Conservation of gene synteny in amniotes allowed definition of target DNA regions in which we searched for sequence similarity. We found the full-length chicken AMEL and the only N-terminal region of DSPP, and both are invalidated genes. AMBN and ENAM disappeared after chromosomal rearrangements occurred in the candidate region in a bird ancestor. Conclusion These findings not only imply that functional teeth with enamel covering, as present in ancestral Aves, will never be obtained in birds, but they also indicate that these four protein genes were dental specific, at least in the last toothed ancestor of modern birds, a specificity which has been questioned in recent years.

  19. Parametric study of propeller boss cap fins for container ships

    Directory of Open Access Journals (Sweden)

    Lim Sang-Seop

    2014-06-01

    Full Text Available The global price of oil, which is both finite and limited in quantity, has been rising steadily because of the increasing requirements for energy in both developing and developed countries. Furthermore, regulations have been strengthened across all industries to address global warming. Many studies of hull resistance, propulsion and operation of ships have been performed to reduce fuel consumption and emissions. This study examined the design parameters of the propeller boss cap fin (PBCF and hub cap for 6,000TEU container ships to improve the propulsion efficiency. The design parameters of PBCF have been selected based on the geometrical shape. Computational fluid dynamics (CFD analysis with a propeller open water (POW test was performed to check the validity of CFD analysis. The design of experiment (DOE case was selected as a full factorial design, and the experiment was analyzed by POW and CFD analysis. Analysis of variance (ANOVA was performed to determine the correlation among design parameters. Four design alternatives of PBCF were selected from the DOE. The shape of a propeller hub cap was selected as a divergent shape, and the divergent angle was determined by the DOE. Four design alternatives of PBCF were attached to the divergent hub cap, and the POW was estimated by CFD. As a result, the divergent hub cap with PBCF has a negative effect on the POW, which is induced by an increase in torque coefficient. A POW test and cavitation test were performed with a divergent hub cap with PBCF to verify the CFD result. The POW test result showed that the open water efficiency was increased approximately 2% with a divergent hub cap compared to a normal cap. The POW test result was similar to the CFD result, and the divergent hub cap with the PBCF models showed lower open water efficiency. This was attributed to an increase in the torque coefficient just like the CFD results. A cavitation test was performed using the 2 models selected. The test

  20. Assessment

    Institute of Scientific and Technical Information of China (English)

    Geoff Brindley

    2005-01-01

    @@ Introduction TERMINOLOGY AND KEY CONCEPTS The term assessment refers to a variety of ways of collecting information on a learner's language ability or achievement. Although testing and assessment are often used interchangeably, the latter is an umbrella term encompassing measurement instruments administered on a ‘one-off’ basis such as tests, as well as qualitative methods of monitoring and recording student learning such as observation, simulations of project work. Assessment is also distinguished from evaluation which is concerned with the overall language programme and not just with what individual students have learnt. Proficiency assessment refers to the assessment of general language abilities acquired by the learner independent of a course of study.This kind of assessment is often done through the administration of standardised commercial language-proficency tests. On the other hand, assessment of achievement aims to establish what a student had learned in relation to a particular course or curriculum (thus frequently carried out by the teacher) .Achievement assesssment may be based either on the specific content of the course or on the course objectives (Hughes 1989).

  1. Climatic and environmental records in Guliya Ice Cap

    Institute of Scientific and Technical Information of China (English)

    姚檀栋; 焦克勤; 田力德; 李忠勤; 李月芳; 刘景寿; 皇翠兰; 谢超; L.G.Thompson; E.M.Thompson

    1995-01-01

    The Guliya Ice Cap is the largest (with a total area of 376.1 m2 and an area cf 131 2 m2 at the flat top), highest (6 700 m a. s.l.) and coldest (with an ice temperature of -19℃ at 10 m depth) ice cap found in Central Asia so far. From 1990 to 1992, the oxygen isotope ratios, microparticle concentrations, anions, cations of a large number of samples from snow pits and ice cores were analysed to study the climatic and environmental characteristics of the Guliya Ice Cap. Being frozen to bedrock and with extremely low ice temperature, the ideal climatic and environmental informarion was recorded in Guliya Ice Cap. The distinct annual and seasonal cycle characteristics of the oxygen isotope ratio, microparticle concentration, anion and cation provide bases to date precisely the high-resolution time series in the ice cap. Oxygen isotope ratios decreased, microparticle concentrations and various chemical elements increased in the colder periods, while oxygen isotope values increased, microparticle concentrat

  2. Canadian ice caps as sources of environmental data

    International Nuclear Information System (INIS)

    Seven surface-to-bedrock ice cores, varying from 129 to 337 m in length, have been recovered from Canadian high Arctic ice caps since 1964. While one (Meighen Island) consists entirely of Holocene ice, the others (Devon and Agassiz ice caps) cover time spans of 100,000 years, similar to those from Greenland. The authors relatively thin ice caps provide simple drilling conditions but give records of various parameters from several holes down a flow line. Comparison of these records continues to provide information on signal-to-noise ratios and ice cap rheology. The major disadvantage of thin ice caps is poor resolution in ice more than 5,000 to 10,000 years old. This is offset, however, by the relative ease of retrieval of significant numbers of pollen grains from all levels in the ice. Thus the authors have been able to use pollen as a paleoenvironmental tool leading, for example, to identification of basal ice layers as Sangamonian in age. Similarly, although annual melting of snow at the surface precludes the possibility of using ice cores for gas analysis, the persistence of variable melt layer concentrations through the Holocene ice has given a continuous melt layer record showing gradual deterioration of summer climate from a warm peak 8,000 to 9,000 years ago, to a cold minimum 200 years ago

  3. Is Vitamin C Beneficial to Patients with CAP?

    Science.gov (United States)

    Li, Yin; Li, Guoping

    2016-08-01

    Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality in elderly and children. Vitamin C is known as a physiological antioxidant, regulating innate immune system in the lung. Vitamin C has been used to prevent and treat CAP. However, the use of vitamin C for preventing and treating CAP has been a subject of controversy. We aim to review the most significant findings about vitamin C supplementation in patients with pneumonia based on literature from the PubMed. First, we reviewed recent advances about the role of oxidative stress in CAP. Oxidative stress is a crucial component of the host defense system and inflammatory response. However, excessive oxidative stress can cause a systemic inflammatory response leading to tissue damage. The degree of oxidative stress has been associated with the severity of CAP. Vitamin C is beneficial to the host defense system by regulating the innate immunity in the lungs. We also discuss the prophylactic use of vitamin C for pneumonia. Vitamin C supplementation decreased the pneumonia risk in patients with vitamin C deficiency. However, it is not beneficial for prophylactic use of vitamin C to prevent pneumonia in the well-nourished population. Finally, we summarize the effect of vitamin C on mechanical ventilation used during respiratory failure. Administration of vitamin C decreases the duration of mechanical ventilation by decreasing oxidative stress. PMID:27363830

  4. Hurricane damaged fixed platforms and wellhead structures

    Energy Technology Data Exchange (ETDEWEB)

    Shuttleworth, E.P.; Frieze, P.A.

    1998-03-01

    The objective of this study was to review data on damages to offshore platforms with a view to determining their suitability for further exploitation and analysis through a preliminary assessment of trends in the data when viewed from a risk standpoint. To realise this objective, a database on hurricane and other storm related damages was generated and past design practice, particularly concerning environmental load levels, was established. Information was gathered on extreme wave heights, damages, platform details, pushover analyses and structural frame load tests. The information was obtained through: a literature survey of journals, conference proceedings, design codes and guidelines; approaches to organisations in the offshore industry with significant experience of hurricanes, storm-damaged structures and pushover analyses; and interrogation of three major databases on offshore storm and other damages - PMB, MMS and WOAD. (author)

  5. RAT DENTAL PULP RESPONSE TO PROPOLIS AS A DIRECT PULP CAPPING AGENT

    OpenAIRE

    Sabir Ardo

    2006-01-01

    The aim of the present study was to assess the response of rat dental pulp to direct pulp capping with ethanol extracts of propolis (EEP). An occlusal cavity was prepared on the right maxillary first molar of Spraque-Dawley rats. The dental pulp was exposed and the lined with a zinc-oxide based filler as a control (group I), or with EEP (group II). Then, each cavity was filled with glass ionomer cement. The animals were sacrificed at week 1, 2, or 4. Biopsy samples were obtained, and these we...

  6. ADAPTABLE ALTERNATE REALITY GAMES PLATFORM

    Directory of Open Access Journals (Sweden)

    Liviu-Adrian Cotfas

    2013-12-01

    Full Text Available In this paper, we present an alternate reality games platform that facilitates the creation of ARG projects with different themes and sizes. The platform is well integrated with the most important social media networks, thus facilitating both the involvement of the public and the creation of a more engaging interaction for the participants. A cloud-based architecture was used in order to allow the platform to easily accommodate projects of various sizes and to provide a good level of scalability. The platform is fully localizable in any language and multiple languages can be used at once to create projects that target users from different countries. An initial project that uses gamification to create an immersive learning environment has been created around the developed platform. The project combines professional and public feedback in order to provide an enhanced learning experience.

  7. Tension leg platform project execution

    Institute of Scientific and Technical Information of China (English)

    Zhang Dagang; Wang Chunsheng; Zhang Tianyu

    2013-01-01

    The first floating platform concept design work for South China Sea is undergoing in DMAR' s office now.This tension leg platform has potential to become the first advanced floating production platform project.Project execution is always a challenge for floating system.This paper focuses on the critical elements of project execution for tension leg platform,and studies potential implications to future oil and gas exploration in South China Sea.There are many factors affecting successful execution of floating system project,including technical issues,engineering management,interface management,etc.There are also failure examples of project execution in the industry.The author has participated 28 large detailed projects and has gained extensive experience on floating projects,with ample hands-on project experiences.A detailed tension leg platform project study example and discussions in depth are presented for future project execution in China deepwater development.

  8. Effect of trihydroxyoctadecadienoic acids on blood levels of prostaglandins E/sub 2/ and F/sub 2. cap alpha. / and of 5-hydroxyeicosatetraenoic acid in rats with alloxan diabetes

    Energy Technology Data Exchange (ETDEWEB)

    Vartanyan, G.S.; Panosyan, A.G.; Karagezyan, K.G.; Gevorkyan, G.A.

    1986-09-01

    The effect of the trihydroxyoctadecadienoic acids (THODA) fraction on blood levels of some eicosanoids and, in particular, of prostaglandins E/sub 2/ and F/sub 2..cap alpha../(PGE/sub 2/ and PGF/sub 2..cap alpha../), and 5-hydroxyeicosatetraenoic acid (5-HETE) in rats with alloxan diabetes was studied. Concentrations of PGE/sub 2/, PGF/sub 2..cap alpha../, and 5-HETE in peripheral blood plasma were determined by radioimmunoassay. To assess the loss of substances during extraction and chromatography, /sup 3/H/sub 8/-PGE/sub 2/, /sup 3/H/sub 8/-PGF/sub 2..cap alpha.., and /sup 3/H/sub 8/-5-HETE were used. Plasma PGE/sub 2/, PGF/sub 2..cap alpha../, and 5-HETE levels in albino rats with alloxan diabetes and after injection of THODA are shown.

  9. Reproducible Experiment Platform

    Science.gov (United States)

    Likhomanenko, Tatiana; Rogozhnikov, Alex; Baranov, Alexander; Khairullin, Egor; Ustyuzhanin, Andrey

    2015-12-01

    Data analysis in fundamental sciences nowadays is an essential process that pushes frontiers of our knowledge and leads to new discoveries. At the same time we can see that complexity of those analyses increases fast due to a) enormous volumes of datasets being analyzed, b) variety of techniques and algorithms one have to check inside a single analysis, c) distributed nature of research teams that requires special communication media for knowledge and information exchange between individual researchers. There is a lot of resemblance between techniques and problems arising in the areas of industrial information retrieval and particle physics. To address those problems we propose Reproducible Experiment Platform (REP), a software infrastructure to support collaborative ecosystem for computational science. It is a Python based solution for research teams that allows running computational experiments on shared datasets, obtaining repeatable results, and consistent comparisons of the obtained results. We present some key features of REP based on case studies which include trigger optimization and physics analysis studies at the LHCb experiment.

  10. Tasseled cap transformation for HJ multispectral remote sensing data

    Science.gov (United States)

    Han, Ling; Han, Xiaoyong

    2015-12-01

    The tasseled cap transformation of remote sensing data has been widely used in environment, agriculture, forest and ecology. Tasseled cap transformation coefficients matrix of HJ multi-spectrum data has been established through Givens rotation matrix to rotate principal component transform vector to whiteness, greenness and blueness direction of ground object basing on 24 scenes year-round HJ multispectral remote sensing data. The whiteness component enhances the brightness difference of ground object, and the greenness component preserves more detailed information of vegetation change while enhances the vegetation characteristic, and the blueness component significantly enhances factory with blue plastic house roof around the town and also can enhance brightness of water. Tasseled cap transformation coefficients matrix of HJ will enhance the application effect of HJ multispectral remote sensing data in their application fields.

  11. Spatial Distribution of Pair Production over the Pulsar Polar Cap

    CERN Document Server

    Belyaev, Mikhail A

    2016-01-01

    Using an analytic, axisymmetric approach that includes general relativity, coupled to a condition for pair production deduced from simulations, we derive general results about the spatial distribution of pair-producing field lines over the pulsar polar cap. In particular, we show that pair production by curvature photons on magnetic field lines operates over only a fraction of the polar cap for an aligned rotator for general magnetic field configurations, assuming the magnetic field varies spatially on a scale that is larger than the size of the polar cap. We compare our result to force-free simulations of a pulsar with a dipole surface field and find excellent agreement. Our work has implications for first-principles simulations of pulsar magnetospheres, and for explaining observations of pulsed radio and high-energy emission.

  12. Buy badges and help finance Cap Loisirs activities!

    CERN Multimedia

    2008-01-01

    Please give a warm welcome to Cap Loisirs’ volunteers who will be manning a stand at the main entrance on Friday 8 February! In honour of St. Valentine’s Day, they will be selling a selection of 5 badges designed by artist Anna Sommer, depicting declarations of love by our friends from the animal kingdom. Price : Frs. 3.- per badge The aim of Fondation Cap Loisirs is to provide leisure activities for mentally handicapped children, adolescents and adults. The Foundation offers a wide range of activities which allow the mentally handicapped to enjoy quality leisure in areas as varied as culture, sport, tourism, travel and artistic expression. Fondation Cap Loisirs Rue de Monthoux 66 – 1201 Geneva – Tel: 022 731 86 00 – CCP Genève 12-5587-5 – caploisirs@caploisirs.ch – http://www.Caploisirs.ch

  13. Open flux merging in an expanding polar cap model

    International Nuclear Information System (INIS)

    The paper presents calculated ionospheric convection patterns that result from dayside magnetic merging when open and closed flux tubes are cut. In the model, a boundary representing the boundary between open and closed field lines expands as newly open flux enters through a gap on the dayside. The gap which represents the dayside merging region mapped to the ionosphere is extended into the polar cap to represent open field line merging. It has been suggested that it is necessary to extend the ionospheric image of the merging line into the polar cap to account for sunward flows observed there. It is shown how the length and the merging potential associated with the extended merging line affects the resulting flow patterns. The results are compared to relevant published data and it is found that an extended merging line indeed induces sunward polar cap flow, but the observed sunward flow is better explained by a day-night ionospheric conductivity gradient. 12 references

  14. CAPS and Munc13: CATCHRs that SNARE vesicles

    Directory of Open Access Journals (Sweden)

    Declan J James

    2013-12-01

    Full Text Available Abstract. CAPS (Calcium-dependent Activator Protein for Secretion, aka CADPS and Munc13 (Mammalian Unc-13 proteins function to prime vesicles for Ca2+-triggered exocytosis in neurons and neuroendocrine cells. CAPS and Munc13 proteins contain conserved C-terminal domains that promote the assembly of SNARE complexes for vesicle priming. Similarities of the C-terminal domains of CAPS/Munc13 proteins with CATCHR (Complex Associated with Tethering Containing Helical Rods domains in multi-subunit tethering complexes have been reported. Multi-subunit tethering complexes coordinate multiple interactions for SNARE complex assembly at constitutive membrane fusion steps. We review aspects of these diverse tethering and priming factors to identify common operating principles.

  15. Plat_Forms -- a contest: The web development platform comparison

    CERN Document Server

    Prechelt, Lutz

    2008-01-01

    "Plat_Forms" is a competition in which top-class teams of three programmers compete to implement the same requirements for a web-based system within 30 hours, each team using a different technology platform (Java EE, .NET, PHP, Perl, Python, or Ruby on Rails). The results will provide new insights into the real (rather than purported) pros, cons, and emergent properties of each platform. The evaluation will analyze many aspects of each solution, both external (usability, functionality, reliability, performance, etc.) and internal (structure, understandability, flexibility, etc.).

  16. CapsID: a web-based tool for developing parsimonious sets of CAPS molecular markers for genotyping

    Directory of Open Access Journals (Sweden)

    Provart Nicholas J

    2006-05-01

    Full Text Available Abstract Background Genotyping may be carried out by a number of different methods including direct sequencing and polymorphism analysis. For a number of reasons, PCR-based polymorphism analysis may be desirable, owing to the fact that only small amounts of genetic material are required, and that the costs are low. One popular and cheap method for detecting polymorphisms is by using cleaved amplified polymorphic sequence, or CAPS, molecular markers. These are also known as PCR-RFLP markers. Results We have developed a program, called CapsID, that identifies snip-SNPs (single nucleotide polymorphisms that alter restriction endonuclease cut sites within a set or sets of reference sequences, designs PCR primers around these, and then suggests the most parsimonious combination of markers for genotyping any individual who is not a member of the reference set. The output page includes biologist-friendly features, such as images of virtual gels to assist in genotyping efforts. CapsID is freely available at http://bbc.botany.utoronto.ca/capsid. Conclusion CapsID is a tool that can rapidly provide minimal sets of CAPS markers for molecular identification purposes for any biologist working in genetics, community genetics, plant and animal breeding, forensics and other fields.

  17. Stratospheric Platforms for Monitoring Purposes

    International Nuclear Information System (INIS)

    Stratospheric platforms are emerging systems based on challenging technology. Goal is to create a platform, payload, and mission design which is able to complement satellite services on a local scale. Applications are close to traditional satellite business in telecommunication, navigation, science, and earth observation and include for example mobile telecommunications, navigation augmentation, atmospheric research, or border control. Stratospheric platforms could potentially support monitoring activities related to safeguards, e.g. by imagery of surfaces, operational conditions of nuclear facilities, and search for undeclared nuclear activities. Stratospheric platforms are intended to be flown in an altitude band between 16 and 30 km, above 16-20 km to take advantage of usually lower winds facilitating station keeping, below 30 km to limit the challenges to achieve a reasonable payload at acceptable platform sizes. Stratospheric platforms could substitute satellites which are expensive and lack upgrade capabilities for new equipment. Furthermore they have practically an unlimited time over an area of interest. It is intended to keep the platforms operational and maintenance free on a 24/7 basis with an average deployment time of 3 years. Geostationary satellites lack resolution. Potential customers like Armed Forces, National Agencies and commercial customers have indicated interest in the use of stratospheric platforms. Governmental entities are looking for cheaper alternatives to communications and surveillance satellites and stratospheric platforms could offer the following potential advantages: Lower operational cost than satellite or UAV (Unmanned Aerial Vehicles) constellation (fleet required); Faster deployment than satellite constellation; Repositioning capability and ability to loiter as required; Persistent long-term real-time services over a fairly large regional spot; Surge capability: Able to extend capability (either monitoring or communications

  18. Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism.

    Directory of Open Access Journals (Sweden)

    Moheshwarnath Issur

    Full Text Available RNA cap binding proteins have evolved to specifically bind to the N7-methyl guanosine cap structure found at the 5' ends of eukaryotic mRNAs. The specificity of RNA capping enzymes towards GTP for the synthesis of this structure is therefore crucial for mRNA metabolism. The fact that ribavirin triphosphate was described as a substrate of a viral RNA capping enzyme, raised the possibility that RNAs capped with nucleotide analogues could be generated in cellulo. Owing to the fact that this prospect potentially has wide pharmacological implications, we decided to investigate whether the active site of the model Paramecium bursaria Chlorella virus-1 RNA capping enzyme was flexible enough to accommodate various purine analogues. Using this approach, we identified several key structural determinants at each step of the RNA capping reaction and generated RNAs harboring various different cap analogues. Moreover, we monitored the binding affinity of these novel capped RNAs to the eIF4E protein and evaluated their translational properties in cellulo. Overall, this study establishes a molecular rationale for the specific selection of GTP over other NTPs by RNA capping enzyme It also demonstrates that RNAs can be enzymatically capped with certain purine nucleotide analogs, and it also describes the impacts of modified RNA caps on specific steps involved in mRNA metabolism. For instance, our results indicate that the N7-methyl group of the classical N7-methyl guanosine cap is not always indispensable for binding to eIF4E and subsequently for translation when compensatory modifications are present on the capped residue. Overall, these findings have important implications for our understanding of the molecular determinants involved in both RNA capping and RNA metabolism.

  19. Base resolution methylome profiling: considerations in platform selection, data preprocessing and analysis.

    Science.gov (United States)

    Sun, Zhifu; Cunningham, Julie; Slager, Susan; Kocher, Jean-Pierre

    2015-08-01

    Bisulfite treatment-based methylation microarray (mainly Illumina 450K Infinium array) and next-generation sequencing (reduced representation bisulfite sequencing, Agilent SureSelect Human Methyl-Seq, NimbleGen SeqCap Epi CpGiant or whole-genome bisulfite sequencing) are commonly used for base resolution DNA methylome research. Although multiple tools and methods have been developed and used for the data preprocessing and analysis, confusions remains for these platforms including how and whether the 450k array should be normalized; which platform should be used to better fit researchers' needs; and which statistical models would be more appropriate for differential methylation analysis. This review presents the commonly used platforms and compares the pros and cons of each in methylome profiling. We then discuss approaches to study design, data normalization, bias correction and model selection for differentially methylated individual CpGs and regions.

  20. Equilibrium magnetic states in individual hemispherical permalloy caps

    Energy Technology Data Exchange (ETDEWEB)

    Streubel, Robert; Schmidt, Oliver G. [Institute for Integrative Nanosciences, IFW Dresden, 01069 Dresden (Germany); Material Systems for Nanoelectronics, Chemnitz University of Technology, 09107 Chemnitz (Germany); Kravchuk, Volodymyr P.; Gaididei, Yuri [Bogolyubov Institute for Theoretical Physics, 03143 Kiev (Ukraine); Sheka, Denis D. [Radiophysics Faculty, Taras Shevchenko National University of Kiev, 01601 Kiev (Ukraine); Makarov, Denys [Institute for Integrative Nanosciences, IFW Dresden, 01069 Dresden (Germany); Kronast, Florian [Helmholtz-Zentrum Berlin fuer Materialien und Energie GmbH, 12489 Berlin (Germany)

    2012-09-24

    The magnetization distributions in individual soft magnetic permalloy caps on non-magnetic spherical particles with sizes ranging from 50 to 800 nm are investigated. We experimentally visualize the magnetic structures at the resolution limit of the x-ray magnetic circular dichroism photoelectron emission microscopy (XMCD-PEEM). By analyzing the so-called tail contrast in XMCD-PEEM, the spatial resolution is significantly enhanced, which allowed us to explore magnetic vortices and their displacement on curved surfaces. Furthermore, cap nanostructures are modeled as extruded hemispheres to determine theoretically the phase diagram of equilibrium magnetic states. The calculated phase diagram agrees well with the experimental observations.