WorldWideScience

Sample records for assessment platform cap

  1. 高度重视临床研究伦理平台建设,大力推进我国CAP评估%Attach Great Importance to Clinical Research Ethics Platform Construction, and Vigorously Promote China CAP Assessment

    Institute of Scientific and Technical Information of China (English)

    白桦; 王思成; 熊宁宁; 张金钟; 张忠元; 徐春波

    2013-01-01

    2012年9月国家中医药管理局正式委托世界中医药学会联合会组织开展“中医药临床研究伦理审查平台评估”(CAP)。通过对已完成评估的20家医疗卫生机构的伦理审查平台情况进行综合分析,结合当前美国的伦理监管体系,论述我国自主评估品牌CAP的重要特点,“以评促建”和“持续改进”的实践与受益,以及大力推进CAP评估的重要意义。%In September 2012, the "Assessment for Ethics Review of Traditional Chinese Medicine (TCM) Re-search with Human Participants" (named CAP, Chinese medicine assessment human research protection system) was officially commissioned to the World Federation of Chinese Medicine Societies to organize by the State Ad-ministration of TCM. Through the assessment of 20 medical institutions, a comprehensive analysis on ethical re-view platform was conducted. Combined with current regulatory system of ethics in the U.S., this article discussed independent assessment on important CAP features of local brands, the practice and benefit of "construction pro-motion based on assessment" and "continuous improvement," as well as the importance of vigorously promote CAP assessment .

  2. Assessing the value of price caps and floors

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This publication assesses the long-term economic and climatic effects of introducing price caps and price floors in hypothetical global climate change mitigation policy. Based on emission trends, abatement costs and equilibrium climate sensitivity from IPCC and IEA reports, this quantitative analysis confirms that price caps could significantly reduce economic uncertainty. This uncertainty stems primarily from unpredictable economic growth and energy prices, and ultimately unabated emission trends. In addition, the development of abatement technologies is uncertain. Furthermore,this analysis shows that rigid targets may entail greater economic risks with little or no comparative advantage for the climate. More ambitious emission objectives, combined with price caps and price floors, could still entail significantly lower expected costs while driving similar, or even slightly better, climatic outcomes in probabilistic terms.

  3. A tailless timing belt climbing platform utilizing dry adhesives with mushroom caps

    Science.gov (United States)

    Krahn, J.; Liu, Y.; Sadeghi, A.; Menon, C.

    2011-11-01

    In many instances, a climbing robot that utilizes dry adhesives as an attachment method may be found to be very useful due to the inherent nature of biomimetic fibrillar dry adhesives in the applications of space, security, surveillance and nuclear reactor cleaning and maintenance. In this paper, a novel tank-like modular robot is developed that does not require a tail to provide a preload to the front of the robot while climbing. Biomimetic fibrillar dry adhesives with mushroom caps manufactured into belts are used as an attachment method. The manufacturing of the dry adhesive belts is discussed and the adhesion properties are examined. The timing belt based climbing platform (TBCP-II) utilizes two tank-like modules connected with an active joint with continual surface-robot distance measuring providing feedback for active adhesive preloading. The mechanical, electronic and software design is discussed. Reliable vertical surface climbing is achieved and the preloading strategy and response is examined. TBCP-II is shown to be capable of both horizontal to vertical and vertical to horizontal surface transfers over both inside and outside corners.

  4. Magnetic susceptibility variations of the Ediacaran cap carbonates in the Yangtze platform and their implications for paleoclimate

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Magnetic susceptibility (MS) data were obtained from 11 sections of the Doushantuo (Ediacaran) cap carbonate that directly overlies the Nantuo glacial diamictite in the southeastern margin of the Yangtze platform. The MS data revealed two regionally correlatable peaks at the bottom and top of the cap carbonate, separated by an interval of low values. The lower MS peak coincides with high percentage of insoluble siliciclastic residues that are compositionally identical to the matrix of the underlying diamictite, suggesting its origin controlled mainly by detrital components during the first phase of cap carbonate deposition at the end of the glaciation. The upper MS peak is associated with high clay content and iron sulfides, and can be interpreted as either derived from enhanced greenhouse weathering that could have brought more terrigenous components into the ocean, or the result of ocean anoxia at the late stage of cap carbonate deposition that could led to formation of abundant iron sulfides. The regionally consistent MS curves from the cap carbonates provided the first geophysical record for the rapid climate change from icehouse to greenhouse conditions in the aftermath of the Neoproterozoic "snowball Earth" event.

  5. Early Experiences with Node-Level Power Capping on the Cray XC40 Platform

    Energy Technology Data Exchange (ETDEWEB)

    Pedretti, Kevin; Olivier, Stephen Lecler; Ferreira, Kurt Brian; Shipman, Galen; Shu, Wei

    2015-10-01

    Power consumption of extreme-scale supercomputers has become a key performance bottleneck. Yet current practices do not leverage power management opportunities, instead running at ''maximum power''. This is not sustainable. Future systems will need to manage power as a critical resource, directing where it has greatest benefit. Power capping is one mechanism for managing power budgets, however its behavior is not well understood. This paper presents an empirical evaluation of several key HPC workloads running under a power cap on a Cray XC40 system, and provides a comparison of this technique with p-state control, demonstrating the performance differences of each. These results show: 1. Maximum performance requires ensuring the cap is not reached; 2. Performance slowdown under a cap can be attributed to cascading delays which result in unsynchronized performance variability across nodes; and, 3. Due to lag in reaction time, considerable time is spent operating above the set cap. This work provides a timely and much needed comparison of HPC application performance under a power cap and attempts to enable users and system administrators to understand how to best optimize application performance on power-constrained HPC systems.

  6. Component Reliability Assessment of Offshore Jacket Platforms

    Directory of Open Access Journals (Sweden)

    V.J. Kurian

    2015-01-01

    Full Text Available Oil and gas industry is one of the most important industries contributing to the Malaysian economy. To extract hydrocarbons, various types of production platforms have been developed. Fixed jacket platform is the earliest type of production structure, widely installed in Malaysia’s shallow and intermediate waters. To date, more than 60% of these jacket platforms have operated exceeding their initial design life, thus making the re-evaluation and reassessment necessary for these platforms to continue to be put in service. In normal engineering practice, system reliability of a structure is evaluated as its safety parameter. This method is however, much complicated and time consuming. Assessing component's reliability can be an alternative approach to provide assurance about a structure’s condition in an early stage. Design codes such as the Working Stress Design (WSD and the Load and Resistance Factor Design (LRFD are well established for the component-level assessment. In reliability analysis, failure function, which consists of strength and load, is used to define the failure event. If the load acting exceeds the capacity of a structure, the structure will fail. Calculation of stress utilization ratio as given in the design codes is able to predict the reliability of a member and to estimate the extent to which a member is being utilised. The basic idea of this ratio is that if it is more than one, the member has failed and vice versa. Stress utilization ratio is a ratio of applied stress, which is the output reaction of environmental loadings acting on the structural member, to the design strength that comes from the member’s geometric and material properties. Adopting this ratio as the failure event, the reliability of each component is found. This study reviews and discusses the reliability for selected members of three Malaysian offshore jacket platforms. First Order Reliability Method (FORM was used to generate reliability index and

  7. Cross-platform digital assessment forms for evaluating surgical skills

    Directory of Open Access Journals (Sweden)

    Steven Arild Wuyts Andersen

    2015-04-01

    Full Text Available A variety of structured assessment tools for use in surgical training have been reported, but extant assessment tools often employ paper-based rating forms. Digital assessment forms for evaluating surgical skills could potentially offer advantages over paper-based forms, especially in complex assessment situations. In this paper, we report on the development of cross-platform digital assessment forms for use with multiple raters in order to facilitate the automatic processing of surgical skills assessments that include structured ratings. The FileMaker 13 platform was used to create a database containing the digital assessment forms, because this software has cross-platform functionality on both desktop computers and handheld devices. The database is hosted online, and the rating forms can therefore also be accessed through most modern web browsers. Cross-platform digital assessment forms were developed for the rating of surgical skills. The database platform used in this study was reasonably priced, intuitive for the user, and flexible. The forms have been provided online as free downloads that may serve as the basis for further development or as inspiration for future efforts. In conclusion, digital assessment forms can be used for the structured rating of surgical skills and have the potential to be especially useful in complex assessment situations with multiple raters, repeated assessments in various times and locations, and situations requiring substantial subsequent data processing or complex score calculations.

  8. Cross-platform digital assessment forms for evaluating surgical skills.

    Science.gov (United States)

    Andersen, Steven Arild Wuyts

    2015-01-01

    A variety of structured assessment tools for use in surgical training have been reported, but extant assessment tools often employ paper-based rating forms. Digital assessment forms for evaluating surgical skills could potentially offer advantages over paper-based forms, especially in complex assessment situations. In this paper, we report on the development of cross-platform digital assessment forms for use with multiple raters in order to facilitate the automatic processing of surgical skills assessments that include structured ratings. The FileMaker 13 platform was used to create a database containing the digital assessment forms, because this software has cross-platform functionality on both desktop computers and handheld devices. The database is hosted online, and the rating forms can therefore also be accessed through most modern web browsers. Cross-platform digital assessment forms were developed for the rating of surgical skills. The database platform used in this study was reasonably priced, intuitive for the user, and flexible. The forms have been provided online as free downloads that may serve as the basis for further development or as inspiration for future efforts. In conclusion, digital assessment forms can be used for the structured rating of surgical skills and have the potential to be especially useful in complex assessment situations with multiple raters, repeated assessments in various times and locations, and situations requiring substantial subsequent data processing or complex score calculations.

  9. Atherosclerotic plaque fibrous cap assessment under an oblique scan plane orientation in carotid MRI

    NARCIS (Netherlands)

    Nieuwstadt, H.A.; Van der Lugt, A.; Kassar, Z.A.M.; Breeuwer, M.; Van der Steen, A.F.W.; Gijsen, F.J.H.

    2014-01-01

    Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e.

  10. Cross-platform digital assessment forms for evaluating surgical skills

    DEFF Research Database (Denmark)

    Andersen, Steven Arild Wuyts

    2015-01-01

    A variety of structured assessment tools for use in surgical training have been reported, but extant assessment tools often employ paper-based rating forms. Digital assessment forms for evaluating surgical skills could potentially offer advantages over paper-based forms, especially in complex...... assessment situations. In this paper, we report on the development of cross-platform digital assessment forms for use with multiple raters in order to facilitate the automatic processing of surgical skills assessments that include structured ratings. The FileMaker 13 platform was used to create a database......, digital assessment forms can be used for the structured rating of surgical skills and have the potential to be especially useful in complex assessment situations with multiple raters, repeated assessments in various times and locations, and situations requiring substantial subsequent data processing...

  11. After the Cap: Risk Assessment, Citizen Science and Disaster Recovery

    Directory of Open Access Journals (Sweden)

    Sabrina McCormick

    2012-12-01

    Full Text Available I used the 2010 Deepwater Horizon oil spill to examine how crowdsourcing is used as a new form of citizen science that provides real time assessments of health-related exposures. Assessing risks of an oil spill, or disasters more generally, is a challenge complicated by the situated nature of knowledge-generation that results in differential perceptions and responses. These processes are critical in the case of the British Petroleum spill in the Gulf Coast since the identification of risks promises to have ramifications for multiple social actors, as well as the health status and long-term resilience of communities in the area. Qualitative interviews, ethnographic observations, and video data were collected with local social movement organizations, grassroots groups, spill workers, fisherman, local residents, scientists, and government representatives within five months of the spill. Findings suggest that crowdsourcing is a new form of citizen science reflecting a transition from lay mapping to an online data gathering system that allows a broader range of participation and the detection of a broader range of impacts. Outcomes of this research promise to help demonstrate and theorize how citizen science relates to risk assessment processes and affects disaster recovery and long-term response.

  12. Price caps and price floors in climate policy: a quantitative assessment

    Energy Technology Data Exchange (ETDEWEB)

    Philibert, Cedric

    2008-12-15

    This study assesses the long-term economic and environmental effects of introducing price caps and price floors in hypothetical climate change mitigation architecture, which aims to reduce global energy-related CO2 emissions by 50% by 2050. Based on abatement costs in IPCC and IEA reports, this quantitative analysis confirms what qualitative analyses have already suggested: introducing price caps could significantly reduce economic uncertainty. This uncertainty stems primarily from unpredictable economic growth and energy prices, and ultimately unabated emission trends. In addition, the development of abatement technologies is uncertain. With price caps, the expected costs could be reduced by about 50% and the uncertainty on economic costs could be one order of magnitude lower. Reducing economic uncertainties may spur the adoption of more ambitious policies by helping to alleviate policy makers' concerns of economic risks. Meanwhile, price floors would reduce the level of emissions beyond the objective if the abatement costs ended up lower than forecasted. If caps and floors are commensurate with the ambition of the policy pursued and combined with slightly tightened emission objectives, climatic results could be on average similar to those achieved with 'straight' objectives (i.e. with no cost-containment mechanism). (auth)

  13. Deliverable 3.3.1 - Assessment Methodology on ISISEMD platform

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth

    2009-01-01

    The overall goal of the ISISEMD project is to offer innovative ICT services to improve the quality of life of elderly persons with cognitive problems or mild dementia and their informal and formal caregivers who provide every day care for them. This will be done via the ISISEMD platform – a platf......The overall goal of the ISISEMD project is to offer innovative ICT services to improve the quality of life of elderly persons with cognitive problems or mild dementia and their informal and formal caregivers who provide every day care for them. This will be done via the ISISEMD platform...... by the project partners. This document is devoted to describing the assessment methodology for the ISISEMD platform in terms of key aspects of the assessment, indicators for evaluation, expected benefits, etc....

  14. Offshore Platform Hydrocarbon Risk Assessment – OPHRA: Feasibility

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan; Kozine, Igor; Markert, Frank

    This report describes the feasibility demonstration of a new method to perform risk assessments for offshore platforms. This method simulates the following phenomena as concurrent sequences of events using the Arena® Discrete Event Simulation (DES) software (version 14.50.00): • Release, ignition...

  15. Safety assessment of platform loadout procedures based on unascertained measures

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Safety assessment of offshore platforms is an urgent task. Such assessments are now focusing on the structure,maintenance, and retirement of a platform. Some methods employed have many shortcomings. For example, they cannot make the reliability adequately explicable. Therefore, a mathematical tool, the unascertained measure, was introduced. First, the basic knowledge of the unascertained sets was introduced briefly. Second, the unascertained measure was defined and credible identification was set up. The method has been introduced into the fields for safety assessment of a jacket loadout procedure.Engineering practices showed that it can complete the safety assessment systematically and scientifically without any assumption. The work should have significance in theory and practice for offshore engineering.

  16. Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery

    KAUST Repository

    Patil, Sachin

    2016-06-29

    Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light responsive nanostructures.Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible light irradiation leading up to 90% of gene silencing in live cells.

  17. Short implants with a nanometer-sized CaP surface provided with either a platform-switched or platform-matched abutment connection in the posterior region : a randomized clinical trial

    NARCIS (Netherlands)

    Telleman, G.; Meijer, H. J. A.; Vissink, A.; Raghoebar, G. M.

    2013-01-01

    ObjectiveTo assess the performance of short nanorough implants (8.5mm in length) provided with either a platform-matched or a platform-switched implant-abutment connection, placed in the resorbed posterior region of partially dentate patients. Materials and MethodsA total of 149 implants with a dual

  18. Platform for Assessing Strategic Alignment Using Enterprise Architecture: Application to E-Government Process Assessment

    CERN Document Server

    Elhari, Kaoutar

    2011-01-01

    This paper presents an overview of S2AEA (v2) (Strategic Alignment Assessment based on Enterprise Architecture (version2)), a platform for modelling enterprise architecture and for assessing strategic alignment based on internal enterprise architecture metrics. The idea of the platform is based on the fact that enterprise architecture provides a structure for business processes and information systems that supports them. This structure can be used to measure the degree of consistency between business strategies and information systems. In that sense, this paper presents a platform illustrating the role of enterprise architecture in the strategic alignment assessment. This assessment can be used in auditing information systems. The platform is applied to assess an e-government process.

  19. Platform for Assessing Strategic Alignment Using Enterprise Architecture: Application to E-Government Process Assessment

    Directory of Open Access Journals (Sweden)

    Kaoutar Elhari

    2011-01-01

    Full Text Available This paper presents an overview of S2AEA (v2 (Strategic Alignment Assessment based on Enterprise Architecture (version2, a platform for modelling enterprise architecture and for assessing strategic alignment based on internal enterprise architecture metrics. The idea of the platform is based on the fact that enterprise architecture provides a structure for business processes and information systems that supports them. This structure can be used to measure the degree of consistency between business strategies and information systems. In that sense, this paper presents a platform illustrating the role of enterprise architecture in the strategic alignment assessment. This assessment can be used in auditing information systems. The platform is applied to assess an e-government process.

  20. System Reliability Assessment of Existing Jacket Platforms in Malaysian Waters

    Directory of Open Access Journals (Sweden)

    V.J. Kurian

    2014-12-01

    Full Text Available Reliability of offshore platforms has become a very important issue in the Malaysian Oil and Gas Industry as, majority of the jacket platforms in Malaysian waters to date, have exceeded their design life. Reliability of a jacket platform can be assessed through reliability index and probability of failure. Conventional metocean consideration uses 100 year return period wave height associated with 100 year return period current velocity and wind speed. However, recent study shows that for Malaysian waters, the proposed metocean consideration should be 100 year return period wave height associated with 10 year return period current velocity and wind speed. Hence, this research investigated the effect of different metocean consideration, to system-based reliability of jacket platforms in Malaysian waters. Prior to that, the effect of different metocean consideration to the pushover analysis has also been studied. Besides, the significance of Pile Soil Interaction (PSI, wave direction and platform geometry were analyzed in a sensitivity study. Pushover analysis was performed on three jacket platforms representing three water regions in Malaysia to obtain Reserve Strength Ratio (RSR as an indicator of the reliability of the jackets. Utilizing sensitivity study parameters mentioned above, seven different case studies were undertaken to study their significance on RSR. The RSR values of each case study were compared and incorporated as resistance model of reliability analysis. Besides, platform specific response model of each jacket has been generated using response surface technique which was later incorporated into the limit state function for reliability analysis. Reliability analysis using First Order Reliability Method (FORM has been conducted in MATLAB to obtain the reliability index and probability of failure. Results from the reliability analysis were compared to analyze the effect of different metocean consideration. In this study, an updated

  1. Platform for Assessing Strategic Alignment Using Enterprise Architecture: Application to E-Government Process Assessment

    OpenAIRE

    Kaoutar Elhari; Bouchaib Bounabat

    2011-01-01

    This paper presents an overview of S2AEA (v2) (Strategic Alignment Assessment based on Enterprise Architecture (version2)), a platform for modelling enterprise architecture and for assessing strategic alignment based on internal enterprise architecture metrics. The idea of the platform is based on the fact that enterprise architecture provides a structure for business processes and information systems that supports them. This structure can be used to measure the degree of consistency between ...

  2. Assessing UAV platform types and optical sensor specifications

    Science.gov (United States)

    Altena, B.; Goedemé, T.

    2014-05-01

    Photogrammetric acquisition with unmanned aerial vehicles (UAV) has grown extensively over the last couple of years. Such mobile platforms and their processing software have matured, resulting in a market which offers off-the-shelf mapping solutions to surveying companies and geospatial enterprises. Different approaches in platform type and optical instruments exist, though its resulting products have similar specifications. To demonstrate differences in acquisitioning practice, a case study over an open mine was flown with two different off-the-shelf UAVs (a fixed-wing and a multi-rotor). The resulting imagery is analyzed to clarify the differences in collection quality. We look at image settings, and stress the fact of photographic experience if manual setting are applied. For mapping production it might be safest to set the camera on automatic. Furthermore, we try to estimate if blur is present due to image motion. A subtle trend seems to be present, for the fast flying platform though its extent is of similar order to the slow moving one. It shows both systems operate at their limits. Finally, the lens distortion is assessed with special attention to chromatic aberration. Here we see that through calibration such aberrations could be present, however detecting this phenomena directly on imagery is not straightforward. For such effects a normal lens is sufficient, though a better lens and collimator does give significant improvement.

  3. Policy assessment of an EU wide flat area CAP payments system

    NARCIS (Netherlands)

    Leeuwen, van M.G.A.; Erjavec, E.; Chantreuil, F.; Hanrahan, K.; Donnellan, T.; Salputra, G.; Kozar, M.

    2011-01-01

    While the evolution of the Common Agricultural previous termPolicynext term (CAP) until 2013 is clear, European Union (EU) budgetary pressures and the perceived unfairness of the distribution of CAP support across Member States has lead to uncertainty over the design of the CAP post 2013. One compre

  4. Graphene Quantum Dots-Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy.

    Science.gov (United States)

    Yao, Xianxian; Niu, Xingxing; Ma, Kexin; Huang, Ping; Grothe, Julia; Kaskel, Stefan; Zhu, Yufang

    2017-01-01

    A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.

  5. Clinical and Radiographic Assessment of the Efficacy of Calcium Silicate Indirect Pulp Capping

    Science.gov (United States)

    Hashem, D.; Mannocci, F.; Patel, S.; Manoharan, A.; Brown, J.E.; Watson, T.F.

    2015-01-01

    The aims of this study were to assess the effectiveness of calcium silicate cement (Biodentine) versus glass ionomer cement (GIC; control group) as indirect pulp capping materials in patients with reversible pulpitis and to compare the effectiveness of cone beam computed tomography (CBCT) versus periapical (PA) radiographs in detecting PA changes at baseline (T0) and at 12 mo (T12) postoperatively. Seventy-two restorations (36 Biodentine, 36 Fuji IX) were placed randomly in 53 patients. CBCT/PA radiographs were taken at T0 and T12. Two calibrated examiners assessed the presence/absence and increase/decrease in the size of existing PA radiolucencies under standardized conditions. The Kappa coefficient evaluated statistically the effectiveness of CBCT versus PA radiographs in detecting PA changes. Chi-square/Mann-Whitney tests were used to evaluate the association between PA changes in CBCT with various clinical measures. Significance was predetermined at α = 0.05. Clinical success rates for Biodentine and Fuji IX GIC were 83.3%. CBCT was significantly more effective in detecting PA radiolucencies compared with radiographs (P = 0.0069). Of the teeth, 65.4% and 90.4% were deemed healthy using CBCT and PA radiographs, respectively, at T12. Healing/healed rates were 17.3%/0%, while new/progressed radiolucency were 30.8%/9.6% with CBCT/PA radiographs, respectively. Seventy-one percent of healed lesions had received Biodentine; 88% of new/progressed lesions received Fuji IX GIC. Teeth presenting with an initial CBCT PA lesion had a failure rate of 63%, whereas teeth with no initial lesion had a failure rate of 16%. Although no statistically significant difference was detected in the clinical efficacy of Biodentine/Fuji IX when used as indirect pulp capping materials in patients with reversible pulpitis, CBCT showed a significant difference in that most healed CBCT lesions had received Biodentine while most that did not heal received Fuji IX. Longer-term follow-up is

  6. Status of Net Metering: Assessing the Potential to Reach Program Caps

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.; Gelman, R.; Bird, L.

    2014-09-01

    Several states are addressing the issue of net metering program caps, which limit the total amount of net metered generating capacity that can be installed in a state or utility service territory. In this analysis, we examine net metering caps to gain perspective on how long net metering will be available in various jurisdictions under current policies. We also surveyed state practices and experience to understand important policy design considerations.

  7. Status of Net Metering: Assessing the Potential to Reach Program Caps (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.; Bird, L.; Gelman, R.

    2014-10-01

    Several states are addressing the issue of net metering program caps, which limit the total amount of net metered generating capacity that can be installed in a state or utility service territory. In this analysis, we examine net metering caps to gain perspective on how long net metering will be available in various jurisdictions under current policies. We also surveyed state practices and experience to understand important policy design considerations.

  8. Assessment of potential anaerobic biotransformation of organic pollutants in sediment caps.

    Science.gov (United States)

    Smith, Anthony M; Kirisits, Mary Jo; Reible, Danny D

    2012-11-15

    In situ capping is a remedial approach for reducing the risk of biota exposure to sediment contaminants. Biotransformation of contaminants in sand-based sediment caps, rarely considered in sediment cap design, could further reduce the exposure risk. The anaerobic biotransformation of benzene, toluene, ethylbenzene, xylenes (BTEX), monochlorobenzene, dichlorobenzenes and naphthalene was evaluated with sediments from Onondaga Lake in dilute sediment slurries and in sand-capped sediment laboratory-scale columns. The percentage of sediment samples demonstrating biotransformation under anaerobic conditions in slurries incubated at 12°C was greatest for BTEX, followed by monochlorobenzene, 1,4-dichlorobenzene, 1,2-dichlorobenzene and 1,3-dichlorobenzene. Only toluene biotransformation was observed in sand cap columns. The rate of toluene biotransformation diminished over time, which might be due to inhibition caused by hydrogen from the experimental setup. Results suggest potential for the biotransformation of toluene, and possibly other pollutants, in sand-based sediment caps under anaerobic conditions at low temperatures.

  9. ASSESSMENT OF RADIONUCLIDES DATABASES IN CAP88 MAINFRAME VERSION 1.0 AND WINDOWS-BASED VERSION 3.0

    Energy Technology Data Exchange (ETDEWEB)

    Farfan, E.; Lee, P.; Jannik, T.; Donnelly, E.

    2008-09-16

    In this study the radionuclide databases for two versions of the Clean Air Act Assessment Package-1988 (CAP88) computer model were assessed in detail. CAP88 estimates radiation dose and the risk of health effects to human populations from radionuclide emissions to air. This program is used by several Department of Energy (DOE) facilities to comply with National Emission Standards for Hazardous Air Pollutants (NESHAP) regulations. CAP88 Mainframe, referred to as Version 1.0 on the Environmental Protection Agency (EPA) website (http://www.epa.gov/radiation/assessment/CAP88/), was the very first CAP88 version released in 1988. Some DOE facilities including the Savannah River Site still employ this version (1.0) while others use the more user-friendly personal computer Windows-based Version 3.0 released in December 2007. Version 1.0 uses the program RADRISK based on International Commission on Radiological Protection (ICRP) Publication 30 as its radionuclide database. Version 3.0 uses half-life, dose and risk factor values based on Federal Guidance Report 13. Differences in these values could cause different results for the same input exposure data (same scenario), depending on which version of CAP88 is used. Consequently, the differences between the two versions are being assessed in detail at Savannah River National Laboratory. The version 1.0 and 3.0 database files contain 496 and 838 radionuclides, respectively, and though one would expect the newer version to include all the 496 radionuclides, thirty-five radionuclides are listed in version 1.0 that are not included in version 3.0. The majority of these has either extremely short or long half-lives or is no longer in production; however, some of the short-lived radionuclides might produce progeny of great interest at DOE sites. In addition, one hundred and twenty-two radionuclides were found to have different half-lives in the two versions, with 21 over 3 percent different and 12 over 10 percent different.

  10. Assessing the measurement of aerosol single scattering albedo by Cavity Attenuated Phase-Shift Single Scattering Monitor (CAPS PMssa)

    Science.gov (United States)

    Perim de Faria, Julia; Bundke, Ulrich; Onasch, Timothy B.; Freedman, Andrew; Petzold, Andreas

    2016-04-01

    The necessity to quantify the direct impact of aerosol particles on climate forcing is already well known; assessing this impact requires continuous and systematic measurements of the aerosol optical properties. Two of the main parameters that need to be accurately measured are the aerosol optical depth and single scattering albedo (SSA, defined as the ratio of particulate scattering to extinction). The measurement of single scattering albedo commonly involves the measurement of two optical parameters, the scattering and the absorption coefficients. Although there are well established technologies to measure both of these parameters, the use of two separate instruments with different principles and uncertainties represents potential sources of significant errors and biases. Based on the recently developed cavity attenuated phase shift particle extinction monitor (CAPS PM_{ex) instrument, the CAPS PM_{ssa instrument combines the CAPS technology to measure particle extinction with an integrating sphere capable of simultaneously measuring the scattering coefficient of the same sample. The scattering channel is calibrated to the extinction channel, such that the accuracy of the single scattering albedo measurement is only a function of the accuracy of the extinction measurement and the nephelometer truncation losses. This gives the instrument an accurate and direct measurement of the single scattering albedo. In this study, we assess the measurements of both the extinction and scattering channels of the CAPS PM_{ssa through intercomparisons with Mie theory, as a fundamental comparison, and with proven technologies, such as integrating nephelometers and filter-based absorption monitors. For comparison, we use two nephelometers, a TSI 3563 and an Aurora 4000, and two measurements of the absorption coefficient, using a Particulate Soot Absorption Photometer (PSAP) and a Multi Angle Absorption Photometer (MAAP). We also assess the indirect absorption coefficient

  11. Care planning needs of palliative home care clients: Development of the interRAI palliative care assessment clinical assessment protocols (CAPs)

    OpenAIRE

    Freeman, Shannon; Hirdes, John P; Stolee, Paul; Garcia, John; Smith, Trevor Frise; Steel, Knight; Morris, John N.

    2014-01-01

    Background The interRAI Palliative Care (interRAI PC) assessment instrument provides a standardized, comprehensive means to identify person-specific need and supports clinicians to address important factors such as aspects of function, health, and social support. The interRAI Clinical Assessment Protocols (CAPs) inform clinicians of priority issues requiring further investigation where specific intervention may be warranted and equip clinicians with evidence to better inform development of a ...

  12. Assessment of heat sources on the control of fast flow of Vestfonna Ice Cap, Svalbard

    Directory of Open Access Journals (Sweden)

    M. Schäfer

    2013-10-01

    Full Text Available The dynamic regime of Svalbard's Nordaustlandet ice caps is dominated by fast flowing outlet glaciers, making assessment of their response to climate change challenging. A key element of the challenge lies in the fact that the motion of fast outlet glaciers occurs largely through basal sliding, and is governed by physical processes at the glacier bed, processes that are difficult both to observe and to simulate. Up to now, most of the sliding laws used in ice flow models were based on uniform parameters with a condition on temperature to identify regions of basal sliding. However these models are usually not able to reproduce observed velocities with sufficient accuracy. With the development of inverse methods, it is now common to infer a spatially varying field of sliding parameters from surface ice-velocity observations. These parameter distributions usually reflect a high spatial variability and represent valuable information to understand and test various hypotheses on physical processes involved in sliding. However, in these models, basal sliding is uncoupled from the thermal regime of basal ice and the evolution of the sliding parameters in prognostic simulations remains problematic. Here we explore the role of different heat sources (friction heating, strain heating and latent heat through percolation of melt water on the development of sliding and fast flow through thermomechanical coupling on Nordaustlandet outlet glaciers. We focus on Vestfonna with a special emphasis on Franklinbreen, a fast flowing outlet glacier which has been observed to accelerate between 1995 and 2008 and possibly already prior to 1995. We try to reconcile the impacts of temperature and heat sources on basal friction coefficients inferred from observed surface velocities during these two periods. Our simulations reproduce a temperature profile from borehole measurements, allowing an interpretation of the vertical temperature structure in terms of temporal

  13. Thermo-economic assessment of the integration of steam cycles on offshore platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter

    2014-01-01

    The integration of steam bottoming cycles on oil platforms is often seen as a possible route to mitigate the CO2-emissions offshore. In this paper, a North Sea platform and its energy requirements are systematically analysed. The site-scale integration of steam networks is assessed by using therm...

  14. Liver Steatosis Assessed by Controlled Attenuation Parameter (CAP) Measured with the XL Probe of the FibroScan: A Pilot Study Assessing Diagnostic Accuracy.

    Science.gov (United States)

    Sasso, Magali; Audière, Stéphane; Kemgang, Astrid; Gaouar, Farid; Corpechot, Christophe; Chazouillères, Olivier; Fournier, Céline; Golsztejn, Olivier; Prince, Stéphane; Menu, Yves; Sandrin, Laurent; Miette, Véronique

    2016-01-01

    To assess liver steatosis, the controlled attenuation parameter (CAP; giving an estimate of ultrasound attenuation ∼3.5 MHz) is available with the M probe of the FibroScan. We report on the adaptation of the CAP for the FibroScan XL probe (center frequency 2.5 MHz) without modifying the range of values (100-400 dB/m). CAP validation was successfully performed on Field II simulations and on tissue-mimicking phantoms. In vivo performance was assessed in a cohort of 59 patients spanning the range of steatosis. In vivo reproducibility was good and similar with both probes. The area under receiver operative characteristic curve was equal to 0.83/0.84 and 0.92/0.91 for the M/XL probes to detect >2% and >16% liver fat, respectively, as assessed by magnetic resonance imaging. Patients can now be assessed simultaneously for steatosis and fibrosis using the FibroScan, regardless of their morphology.

  15. WCDMA Uplink Interference Assessment from Multiple High Altitude Platform Configurations

    Directory of Open Access Journals (Sweden)

    A. Mohammed

    2008-06-01

    Full Text Available We investigate the possibility of multiple high altitude platform (HAP coverage of a common cell area using a wideband code division multiple access (WCDMA system. In particular, we study the uplink system performance of the system. The results show that depending on the traffic demand and the type of service used, there is a possibility of deploying 3–6 HAPs covering the same cell area. The results also show the effect of cell radius on performance and the position of the multiple HAP base stations which give the worst performance.

  16. The clubfoot assessment protocol (CAP; description and reliability of a structured multi-level instrument for follow-up

    Directory of Open Access Journals (Sweden)

    Jarnlo Gun-Britt

    2005-07-01

    Full Text Available Abstract Background In most clubfoot studies, the outcome instruments used are designed to evaluate classification or long-term cross-sectional results. Variables deal mainly with factors on body function/structure level. Wide scorings intervals and total sum scores increase the risk that important changes and information are not detected. Studies of the reliability, validity and responsiveness of these instruments are sparse. The lack of an instrument for longitudinal follow-up led the investigators to develop the Clubfoot Assessment Protocol (CAP. The aim of this article is to introduce and describe the CAP and evaluate the items inter- and intra reliability in relation to patient age. Methods The CAP was created from 22 items divided between body function/structure (three subgroups and activity (one subgroup levels according to the International Classification of Function, Disability and Health (ICF. The focus is on item and subgroup development. Two experienced examiners assessed 69 clubfeet in 48 children who had a median age of 2.1 years (range, 0 to 6.7 years. Both treated and untreated feet with different grades of severity were included. Three age groups were constructed for studying the influence of age on reliability. The intra- rater study included 32 feet in 20 children who had a median age of 2.5 years (range, 4 months to 6.8 years. The Unweighted Kappa statistics, percentage observer agreement, and amount of categories defined how reliability was to be interpreted. Results The inter-rater reliability was assessed as moderate to good for all but one item. Eighteen items had kappa values > 0.40. Three items varied from 0.35 to 0.38. The mean percentage observed agreement was 82% (range, 62 to 95%. Different age groups showed sufficient agreement. Intra- rater; all items had kappa values > 0.40 [range, 0.54 to 1.00] and a mean percentage agreement of 89.5%. Categories varied from 3 to 5. Conclusion The CAP contains more detailed

  17. Assessment of heat sources on the control of fast flow of Vestfonna ice cap, Svalbard

    Science.gov (United States)

    Schäfer, M.; Gillet-Chaulet, F.; Gladstone, R.; Pettersson, R.; Pohjola, V. A.; Strozzi, T.; Zwinger, T.

    2014-10-01

    Understanding the response of fast flowing ice streams or outlet glaciers to changing climate is crucial in order to make reliable projections of sea level change over the coming decades. Motion of fast outlet glaciers occurs largely through basal motion governed by physical processes at the glacier bed, which are not yet fully understood. Various subglacial mechanisms have been suggested for fast flow but common to most of the suggested processes is the requirement of presence of liquid water, and thus temperate conditions. We use a combination of modelling, field, and remote observations in order to study links between different heat sources, the thermal regime and basal sliding in fast flowing areas on Vestfonna ice cap. A special emphasis lies on Franklinbreen, a fast flowing outlet glacier which has been observed to accelerate recently. We use the ice flow model Elmer/Ice including a Weertman type sliding law and a Robin inverse method to infer basal friction parameters from observed surface velocities. Firn heating, i.e. latent heat release through percolation of melt water, is included in our model; its parameterisation is calibrated with the temperature record of a deep borehole. We found that strain heating is negligible, whereas friction heating is identified as one possible trigger for the onset of fast flow. Firn heating is a significant heat source in the central thick and slow flowing area of the ice cap and the essential driver behind the ongoing fast flow in all outlets. Our findings suggest a possible scenario of the onset and maintenance of fast flow on the Vestfonna ice cap based on thermal processes and emphasise the role of latent heat released through refreezing of percolating melt water for fast flow. However, these processes cannot yet be captured in a temporally evolving sliding law. In order to simulate correctly fast flowing outlet glaciers, ice flow models not only need to account fully for all heat sources, but also need to incorporate

  18. Composition in the Context of the CAP: A Case Study of the Interplay between Assessment and School Life. Technical Report No. 58.

    Science.gov (United States)

    Loofbourrow, Peggy Trump

    A study was designed to evaluate the interplay between the California Assessment Program (CAP), the broadest assessment California's students undergo, and one junior high school. The study was conducted at a racially and socioeconomically heterogeneous school in the San Francisco Bay area. Observations were made on the school, department, and…

  19. An integrated platform for assessing biologics (Conference Presentation)

    Science.gov (United States)

    Schein, Perry; O'Dell, Dakota; Erickson, David

    2016-04-01

    Protein therapeutics are a rapidly growing portion of the pharmaceuticals market and have many significant advantages over traditional small molecule drugs. As this market expands, however, critical regulatory and quality control issues remain, most notably the problem of protein aggregation. Individual target proteins often aggregate into larger masses which trigger an immune response in the body, which can reduce the efficacy of the drug for its intended purpose, or cause serious anaphylactic side-effects. Although detecting and minimizing aggregate formation is critical to ensure an effective product, aggregation dynamics are often highly complicated and there is little hope of reliable prediction and prevention from first principles. This problem is compounded for aggregates in the subvisible range of 100 nm to 10 micrometers where traditional techniques for detecting aggregates have significant limitations. Here, we present an integrated optofluidic platform for detecting nanoscale protein aggregates and characterizing interactions between these aggregates and a reference surface. By delivering light to a solution of proteins with an optical waveguide, scattered light from individual protein aggregates can be detected and analyzed to determine the force profile between each particle and the waveguide surface. Unlike existing methods which only determine size or charge, our label-free screening technique can directly measure the surface interaction forces between single aggregates and the glass substrate. This direct measurement capability may allow for better empirical predictions of the stability of protein aggregates during drug manufacturing and storage.

  20. Cell Viability Assessment: Toward Content-Rich Platforms

    Science.gov (United States)

    Ramirez, Christina Nicole; Antczak, Christophe; Djaballah, Hakim

    2013-01-01

    Importance of the field Monitoring cell viability in vitro is critical in many areas of biomedical research, and the ultimate goal in drug discovery is the ability to predict the in vivo toxicology of drug candidates based on their toxicity profile in vitro. Over the last decade, the contribution of high-throughput screening (HTS) toward this goal has been tremendous, providing the ability to screen compounds in parallel against multiple cell types. However, the toxic effects of drug candidates uncovered during clinical trials are by far the main reason for their failure. Over the same period, our understanding of programmed cell death has evolved dramatically with the identification of critical control points in the cell death pathways. As a result, cell viability should no longer be characterized solely on the basis of discrete endpoint measurements such as membrane permeability. Areas covered in this review/What the reader will gain This review summarizes the traditional viability assays currently commercially available, focusing on methods amenable to high density format. Assays categorized into the following classes are discussed: dye exclusion assays, DNA condensation-based assays and assays monitoring a metabolic function. We describe each approach, and using case studies, we emphasize their limitations. Take home message Current low-content methods based on single parameter readouts are prone to error due to the heterogeneity of cell populations and the multi-faceted nature of cell death. High-content approaches based on continuous, multiplexed readouts are becoming increasingly important for monitoring multiple markers of cell death induction simultaneously, on a cell by cell basis. The use of such content-rich platforms is a necessity to predict the toxicology of drug candidates accurately. PMID:22823019

  1. Container-based sanitation: assessing costs and effectiveness of excreta management in Cap Haitien, Haiti.

    Science.gov (United States)

    Tilmans, Sebastien; Russel, Kory; Sklar, Rachel; Page, Leah; Kramer, Sasha; Davis, Jennifer

    2015-04-01

    Container-based sanitation (CBS) - in which wastes are captured in sealable containers that are then transported to treatment facilities - is an alternative sanitation option in urban areas where on-site sanitation and sewerage are infeasible. This paper presents the results of a pilot household CBS service in Cap Haitien, Haiti. We quantify the excreta generated weekly in a dense urban slum,((1)) the proportion safely removed via container-based public and household toilets, and the costs associated with these systems. The CBS service yielded an approximately 3.5-fold decrease in the unmanaged share of faeces produced, and nearly eliminated the reported use of open defecation and "flying toilets" among service recipients. The costs of this pilot small-scale service were higher than those of large-scale waterborne sewerage, but economies of scale have the potential to reduce CBS costs over time. The paper concludes with a discussion of planning and policy implications of incorporating CBS into the menu of sanitation options for rapidly growing cities.

  2. Accuracy assessment of the integration of GNSS and a MEMS IMU in a terrestrial platform.

    Science.gov (United States)

    Madeira, Sergio; Yan, Wenlin; Bastos, Luísa; Gonçalves, José A

    2014-11-04

    MEMS Inertial Measurement Units are available at low cost and can replace expensive units in mobile mapping platforms which need direct georeferencing. This is done through the integration with GNSS measurements in order to achieve a continuous positioning solution and to obtain orientation angles. This paper presents the results of the assessment of the accuracy of a system that integrates GNSS and a MEMS IMU in a terrestrial platform. We describe the methodology used and the tests realized where the accuracy of the positions and orientation parameters were assessed using an independent photogrammetric technique employing cameras that integrate the mobile mapping system developed by the authors. Results for the accuracy of attitude angles and coordinates show that accuracies better than a decimeter in positions, and under a degree in angles, can be achieved even considering that the terrestrial platform is operating in less than favorable environments.

  3. Construction of life cycle assessment software system platform

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ya-ping; ZUO Yu-hui

    2007-01-01

    There has not been life cycle assessment (LCA) software applicable to China's products. To faciliate the develop-ment of LCA software system in China, we built an object-oriented LCA software system plantform based on LCA international standards ISO 14040 to ISO 14043 and the commonness of diverse products. The system includes six modules: disassembly module, data collection module, arithmetic module, drawing module, database module and control module. It evaluates all economic and environmental impacts during the whole life cycle of a product. The integrated life cycle inventory database system allows dynamic expansion, which makes the effort required for data collection reduce with the increase of the system's application. With the improvement of human environmental-awareness, the demand of environment-friendly products is increasing, and ecological design of products has become a critical part in products development. Consummation of the LCA software system will provide a powerful tool for designing and developing Chinese ecological products.

  4. Factors affecting the accuracy of controlled attenuation parameter (CAP in assessing hepatic steatosis in patients with chronic liver disease.

    Directory of Open Access Journals (Sweden)

    Kyu Sik Jung

    Full Text Available BACKGROUND & AIMS: Controlled attenuation parameter (CAP can measure hepatic steatosis. However, factors affecting its accuracy have not been described yet. This study investigated predictors of discordance between liver biopsy (LB and CAP. METHODS: A total of 161 consecutive patients with chronic liver disease who underwent LB and CAP were enrolled prospectively. Histological steatosis was graded as S0 (66% of hepatocytes. Cutoff CAP values were calculated from our cohort (250, 301, and 325 dB/m for ≥ S1, ≥ S2, and S3. Discordance was defined as a discrepancy of at least two steatosis stages between LB and CAP. RESULTS: The median age (102 males and 59 females was 49 years. Repartition of histological steatosis was as follows; S0 26.1% (n = 42, S1 49.7% (n = 80, S2 20.5% (n = 33, and S3 3.7% (n = 6. In multivariate linear regression analysis, CAP value was independently associated with steatosis grade along with body mass index (BMI and interquartile range/median of CAP value (IQR/MCAP (all P<0.05. Discordance was identified in 13 (8.1% patients. In multivariate analysis, histological S3 (odd ratio [OR], 9.573; 95% confidence interval [CI], 1.207-75.931; P = 0.033 and CAP value (OR, 1.020; 95% CI, 1.006-1.034; P = 0.006 were significantly associated with discordance, when adjusting for BMI, IQR/MCAP, and necroinflammation, reflected by histological activity or ALT level. CONCLUSIONS: Patients with high grade steatosis or high CAP values have a higher risk of discordance between LB and CAP. Further studies are needed to improve the accuracy of CAP interpretation, especially in patients with higher CAP values.

  5. A Global Refiability Assessment Method on Aging Offshore Platforms with Corrosion and Cracks

    Institute of Scientific and Technical Information of China (English)

    JI Chun-yan; LI Shan-shan; CHEN Ming-lu

    2009-01-01

    Corrosion and fatigue cracks are major threats to the structural integrity of aging offshore platforms.For the rational estimation of the safety levels of aging platforms,a global reliability assessment approach for aging offshore platforms with corrosion and fatigue cracks is presented in this paper.The base shear capacity is taken as the global ultimate strength of the offshore plaffoms,it is modeled as a random process that decreases with time in the presence of corrosion and fatigue crack propagation.And the corrosion and fatigue crack growth rates in the main members and key joints are modeled as random variables.A simulation method of the extreme wave loads which are applied to the structures of offshore platforms is proposed too.Furthermore,the statistics of global base shear capacity and extreme wave loads are obtained by Monte Carlo simulation method.On the basis of the limit state equation of global failure mode,the instantaneous reliability and time dependent reliability assessment methods are both presented in this paper.Finally the instantaueous reliability index and time dependent failure probability of a jacket platform are estimated with different ages in the demonstration example.

  6. Roadmap for the European Platform on Life Cycle Assessment: facilitating data collection and sustainability assessments for policy and business

    OpenAIRE

    2013-01-01

    After its debut in the European Commission‟s Integrated Product Policy (COM (2003)302) as the “best framework for assessing the potential environmental impacts of products”, Life Cycle Assessment (LCA) has become increasingly essential in support of community policies and business. Focus has been primarily on establishing agreed methods, both within Europe and internationally. The EC‟s European Platform on LCA has continued to address the equally essential issue of data availability, coherenc...

  7. A Geospatial Web Platform for Natural Hazard Exposure Assessment in the Insurance Sector

    Science.gov (United States)

    Iris, Julien; Chemitte, Jérôme; Napoli, Aldo

    The work of natural hazard exposure assessment involves various geographic data sets (referential, hazard, assets) and various disciplines intended for insurance professionals (catastrophe modeling, prevention engineering). The emergence of Geospatial Web technology induces the emergence of new sets of online services. Mission Risques Naturels (MRN) is a French actor in the mutualization and diffusion of information on natural hazards knowledge and prevention for the general interest of insurance professionals. The MRN Web-GIS platform has been built to address these requirements. This chapter starts by presenting the role of MRN in the network of natural hazard assessment. It then presents Geospatial Web tools for natural hazard exposure assessment as well as the system architecture of the MRN Web-GIS platform, including all its services.

  8. The ORNL Indoor Air Quality Study: Re-cap, Context, and Assessment on Radon

    Energy Technology Data Exchange (ETDEWEB)

    Tonn, Bruce Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rose, Erin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ternes, Mark P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    As part of the retrospective evaluation of the U.S. Department of Energy s low-income Weatherization Assistance Program that was led by Oak Ridge National Laboratory (ORNL), an assessment of the impacts of weatherization on indoor air quality (IAQ) was conducted. This assessment included nearly 500 treatment and control homes across the country. Homes were monitored for carbon monoxide, radon, formaldehyde, temperature and humidity pre- and post-weatherization. This report focuses on the topic of radon and addresses issues not thoroughly discussed in the original IAQ report. The size, scope and rigor of the radon component of the IAQ study are compared to previous studies that assessed the impacts of weatherization on indoor radon levels. It is found that the ORNL study is by far the most extensive study conducted to date, though the ORNL results are consistent with the findings of the other studies. However, the study does have limitations related to its reliance on short-term measurements of radon and inability to attribute changes in radon levels in homes post-weatherization to specific weatherization measures individually or in combination.

  9. A virtual reality platform for assessment and rehabilitation of neglect using a kinect.

    Science.gov (United States)

    Cipresso, Pietro; Serino, Silvia; Pedroli, Elisa; Gaggioli, Andrea; Riva, Giuseppe

    2014-01-01

    Unilateral Spatial Neglect (USN) is normally assessed with paper-and-pencil tests. Virtual reality can be an effective neuropsychological tool for a more ecological and functional assessment and rehabilitation of neglect. We developed a 3D Virtual Reality platform - NeuroVirtual 3D - for the assessment and rehabilitation of cognitive deficits, in particular for USN. Within the virtual environments it is possible to interact with virtual objects and execute specific exercises using a Microsoft Kinect. Through the analysis of different grasping tasks it is possible to evaluate in an ecological way the patients' ability to find and handle objects in both sides of the virtual space.

  10. Death cap

    DEFF Research Database (Denmark)

    Rudbæk, Torsten R; Kofoed, Pernille Bouteloup; Bove, Jeppe

    2014-01-01

    Death cap (Amanita phalloides) is commonly found and is one of the five most toxic fungi in Denmark. Toxicity is due to amatoxin, and poisoning is a serious medical condition, causing organ failure with potential fatal outcome. Acknowledgement and clarification of exposure, symptomatic and focused...

  11. USGS National Assessment of Oil and Gas Project - Cherokee Platform Province Assessment Units

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Assessment Unit is the fundamental unit used in the National Assessment Project for the assessment of undiscovered oil and gas resources. The Assessment Unit is...

  12. Modeling platform for integrated assessment of intervention propolsals in localities : case study, Medellin Metropolitan Area (Colombia)

    OpenAIRE

    2011-01-01

    This dissertation proposes a comprehensive framework for conceptual, methodological and instrumental contribution to urban intervention planning and public policy design. For a Latin American case study, a prospective multi-methodology modeling platform was developed to support the novel proposed approaches for intervention assessment, as well as to establish a knowledge building dynamic for planners using multidisciplinary discussion and, most importantly, paradigm confrontation and change. ...

  13. Silver-capped silicon nanopillar platforms for adsorption studies of folic acid using surface enhanced Raman spectroscopy and density functional theory

    DEFF Research Database (Denmark)

    Castillo, Jaime; Rindzevicius, Tomas; Wu, Kaiyu

    2015-01-01

    The study of the interactions of folic acid (FA) with surface enhanced Raman scattering substrates is relevant for understanding its adsorption mechanismand for fabricating analytical devices for detection ofmalignant cells over-expressing folate receptors. This paper presents a study of the adso......The study of the interactions of folic acid (FA) with surface enhanced Raman scattering substrates is relevant for understanding its adsorption mechanismand for fabricating analytical devices for detection ofmalignant cells over-expressing folate receptors. This paper presents a study...... of the adsorption of FA on silver-capped silicon nanopillar substrates employing surface enhanced Raman scattering spectroscopy and density functional theory calculations. The experimentally observed vibrations from free FA and FA bound to the Ag surface display different vibrational spectra indicating chemical...... interaction of the molecule with the metal surface. Density functional theory calculations show that the Ag–FA interaction is primarily through the nitrogen from the pteridine ring anchoring to the Ag metal surface. To investigate the Ag–FA binding behavior further, the adsorption isotherm of FA on the silver...

  14. Apical cap

    Energy Technology Data Exchange (ETDEWEB)

    McLoud, T.C.; Isler, R.J.; Novelline, R.A.; Putman, C.E.; Simeone, J.; Stark, P.

    1981-08-01

    Apical caps, either unilateral or bilateral, are a common feature of advancing age and are usually the result of subpleural scarring unassociated with other diseases. Pancoast (superior sulcus) tumors are a well recognized cause of unilateral asymmetric apical density. Other lesions arising in the lung, pleura, or extrapleural space may produce unilateral or bilateral apical caps. These include: (1) inflammatory: tuberculosis and extrapleural abscesses extending from the neck; (2) post radiation fibrosis after mantle therapy for Hodgkin disease or supraclavicular radiation in the treatment of breast carcinoma; (3) neoplasm: lymphoma extending from the neck or mediastinum, superior sulcus bronchogenic carcinoma, and metastases; (4) traumatic: extrapleural dissection of blood from a ruptured aorta, fractures of the ribs or spine, or hemorrhage due to subclavian line placement; (5) vascular: coarctation of the aorta with dilated collaterals over the apex, fistula between the subclavian artery and vein; and (6) miscellaneous: mediastinal lipomatosis with subcostal fat extending over the apices.

  15. Elementary Writing Assessment Platforms: A Quantitative Examination of Online versus Offline Writing Performance of Fifth-Grade Students

    Science.gov (United States)

    Heath, Vickie L.

    2013-01-01

    This quantitative study explored if significant differences exist between how fifth-grade students produce a written response to a narrative prompt using online versus offline writing platforms. The cultural and social trend of instructional and assessment writing paradigms in education is shifting to online writing platforms (National Assessment…

  16. A Kinect-Based Physiotherapy and Assessment Platform for Parkinson’s Disease Patients

    Directory of Open Access Journals (Sweden)

    Ioannis Pachoulakis

    2016-01-01

    Full Text Available We report on a Kinect-based, augmented reality, real-time physiotherapy platform tailored to Parkinson’s disease (PD patients. The platform employs a Kinect sensor to extract real-time 3D skeletal data (joint information from a patient facing the sensor (at 30 frames per second. In addition, a small collection of exercises practiced in traditional physiotherapy for PD patients has been implemented in the Unity 3D game engine. Each exercise employs linear or circular movement patterns and poses very light-weight processing demands on real-time computations. During an exercise, trainer instruction demonstrates correct execution and Kinect-provided 3D joint data are fed to the game engine and compared to exercise-specific control routines to assess proper posture and body control in real time. When an exercise is complete, performance metrics appropriate for that exercise are computed and displayed on screen to enable the attending physiotherapist to fine-tune the exercise to the abilities/needs of an individual patient as well as to provide performance feedback to the patient. The platform can operate in a physiotherapist’s office and, following appropriate validation, in a home environment. Finally, exercises can be parameterized meaningfully, depending on the intended purpose (motor assessment versus plain exercise at home.

  17. A Kinect-Based Physiotherapy and Assessment Platform for Parkinson's Disease Patients.

    Science.gov (United States)

    Pachoulakis, Ioannis; Xilourgos, Nikolaos; Papadopoulos, Nikolaos; Analyti, Anastasia

    2016-01-01

    We report on a Kinect-based, augmented reality, real-time physiotherapy platform tailored to Parkinson's disease (PD) patients. The platform employs a Kinect sensor to extract real-time 3D skeletal data (joint information) from a patient facing the sensor (at 30 frames per second). In addition, a small collection of exercises practiced in traditional physiotherapy for PD patients has been implemented in the Unity 3D game engine. Each exercise employs linear or circular movement patterns and poses very light-weight processing demands on real-time computations. During an exercise, trainer instruction demonstrates correct execution and Kinect-provided 3D joint data are fed to the game engine and compared to exercise-specific control routines to assess proper posture and body control in real time. When an exercise is complete, performance metrics appropriate for that exercise are computed and displayed on screen to enable the attending physiotherapist to fine-tune the exercise to the abilities/needs of an individual patient as well as to provide performance feedback to the patient. The platform can operate in a physiotherapist's office and, following appropriate validation, in a home environment. Finally, exercises can be parameterized meaningfully, depending on the intended purpose (motor assessment versus plain exercise at home).

  18. Assessment of Sentinel-3/OLCI Sub-Pixel Variability and Platform Impact Using Landsat-8/OLI

    Science.gov (United States)

    Vanhellemont, Quinten; Ruddick, Kevin

    2015-12-01

    Validation and calibration of ocean colour sensors with in situ data is key for successful exploitation of their data. Ship campaigns are expensive and provide a low number of good matchups, whereas autonomous systems can typically provide a matchup for each cloud-free scene. With the distribution of free and high quality imagery from Landsat-8, the amount of natural spatial variability in the coastal zone becomes quantifiable, and the possible impact of measurement platforms (ships, moorings, structures) on the signal measured by the satellite becomes clear. Here we present the use of Landsat-8/OLI imagery (30m) to assess the spatial variability within a Sentinel-3/OLCI pixel (300m) at validation sites, as well as an illustration of the impacts of the measurement platforms on the satellite measurement.

  19. Mammalian CAP interacts with CAP, CAP2, and actin.

    Science.gov (United States)

    Hubberstey, A; Yu, G; Loewith, R; Lakusta, C; Young, D

    1996-06-01

    We previously identified human CAP, a homolog of the yeast adenylyl cyclase-associated protein. Previous studies suggest that the N-terminal and C-terminal domains of CAP have distinct functions. We have explored the interactions of human CAP with various proteins. First, by performing yeast two-hybrid screens, we have identified peptides from several proteins that interact with the C-terminal and/or the N-terminal domains of human CAP. These peptides include regions derived from CAP and BAT3, a protein with unknown function. We have further shown that MBP fusions with these peptides can associate in vitro with the N-terminal or C-terminal domains of CAP fused to GST. Our observations indicate that CAP contains regions in both the N-terminal and C-terminal domains that are capable of interacting with each other or with themselves. Furthermore, we found that myc-epitope-tagged CAP coimmunoprecipitates with HA-epitope-tagged CAP from either yeast or mammalian cell extracts. Similar results demonstrate that human CAP can also interact with human CAP2. We also show that human CAP interacts with actin, both by the yeast two-hybrid test and by coimmunoprecipitation of epitope-tagged CAP from yeast or mammalian cell extracts. This interaction requires the C-terminal domain of CAP, but not the N-terminal domain. Thus CAP appears to be capable of interacting in vivo with other CAP molecules, CAP2, and actin. We also show that actin co-immunoprecipitates with HA-CAP2 from mammalian cell extracts.

  20. An implementation and test platform for wide area stability assessment methods

    DEFF Research Database (Denmark)

    Wittrock, Martin Lindholm; Jóhannsson, Hjörtur

    2013-01-01

    scenario and automatically generating synthetic PMU snapshots of the system conditions. To demonstrate the platform’s potential for supporting research and development of wide area algorithms, a method to detect voltage instability is implemented and tested, giving results consistent with results from......This paper presents a software platform developed in MatLab with the purpose of supporting research, Development and testing of wide area algorithms for stability assessment and control. The development and testing process of algorithms exploiting real time wide area data from Phasor Measurement...

  1. Exergetic assessment of energy systems on North Sea oil and gas platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Pierobon, Leonardo; Elmegaard, Brian

    2013-01-01

    offshore system is described: its thermodynamic performance is assessed by performing an exergy accounting and rules of thumb for oil and gas platforms are derived. Simulations are built and conducted with the tools Aspen Plus_, Dynamic Network Analysis and Aspen HYSYS_. 62e65% of the total exergy......-temperature gases from the utility and flaring systems is the major contributor to the exergy losses. These findings suggest to focus efforts on a better use of the waste heat contained in the exhaust gases and on the ways in which the gas compression performance can be improved. © 2013 Elsevier Ltd. All rights...

  2. Assessing the role of the ASP56/CAP homologue of Dictyostelium discoideum and the requirements for subcellular localization.

    Science.gov (United States)

    Noegel, A A; Rivero, F; Albrecht, R; Janssen, K P; Köhler, J; Parent, C A; Schleicher, M

    1999-10-01

    The CAP (cyclase-associated protein) homologue of Dictyostelium discoideum is a phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulated G-actin sequestering protein which is present in the cytosol and shows enrichment at plasma membrane regions. It is composed of two domains separated by a proline rich stretch. The sequestering activity has been localized to the C-terminal domain of the protein, whereas the presence of the N-terminal domain seems to be required for PIP(2)-regulation of the sequestering activity. Here we have constructed GFP-fusions of N- and C-domain and found that the N-terminal domain showed CAP-specific enrichment at the anterior and posterior ends of cells like endogenous CAP irrespective of the presence of the proline rich region. Mutant cells expressing strongly reduced levels of CAP were generated by homologous recombination. They had an altered cell morphology with very heterogeneous cell sizes and exhibited a cytokinesis defect. Growth on bacteria was normal both in suspension and on agar plates as was phagocytosis of yeast and bacteria. In suspension in axenic medium mutant cells grew more slowly and did not reach saturation densities observed for wild-type cells. This was paralleled by a reduction in fluid phase endocytosis. Development was delayed by several hours under all conditions assayed, furthermore, motile behaviour was affected.

  3. Radioactive airborne effluents and the environmental impact assessment of CAP1400 nuclear power plant under normal operation

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Qiong; Guo, RuiPing; Zhang, ChunMing; Chen, XiaoQiu; Wang, Bo, E-mail: wangbo@chinansc.cn

    2014-12-15

    Highlights: • Typical radionuclides dispersion from CAP1400 under normal operation was simulated. • Modified Gaussian model considered radioactive decay, dry and wet deposition and so on. • The radioactive impact pathways on the public through atmosphere were compared. • The maximum individual effective dose was lower than the public irradiation limit. - Abstract: China Advanced Passive nuclear power plant with installed capacity reaching to 1400 MW (CAP1400) is independently designed as the China's state-of-the-art third generation nuclear power brand based on AP1000 technology digestion and absorption. The concentration of typical radionuclides dispersed from CAP1400 under normal operation was calculated with modified Gaussian model, considering mixed layer height, dry deposition, wet deposition, radioactive decay and so on. The atmospheric dispersion factors, ground deposition rate, individual dose and public dose were also investigated to estimate the radioactive effects of CAP1400 under normal operation on surrounding environment and human beings. The radioactive impact pathways on the public through atmosphere, such as immersion irradiation in the smoke plume, internal irradiation from ingestion and inhalation and external irradiation from surface deposition were briefly introduced with focus on the comparison of the maximum individual effective dose to different group from atmospheric dispersion. All computation results show that the maximum individual irradiation dose happened to children with total effective irradiation dose of 4.52E−03 mSv/y, which was lower than the public irradiation limit of 0.25 mSv/y.

  4. Glaciers and small ice caps in the macro-scale hydrological cycle - an assessment of present conditions and future changes

    Science.gov (United States)

    Lammers, Richard; Hock, Regine; Prusevich, Alexander; Bliss, Andrew; Radic, Valentina; Glidden, Stanley; Grogan, Danielle; Frolking, Steve

    2014-05-01

    Glacier and small ice cap melt water contributions to the global hydrologic cycle are an important component of human water supply and for sea level rise. This melt water is used in many arid and semi-arid parts of the world for direct human consumption as well as indirect consumption by irrigation for crops, serving as frozen reservoirs of water that supplement runoff during warm and dry periods of summer when it is needed the most. Additionally, this melt water reaching the oceans represents a direct input to sea level rise and therefore accurate estimates of this contribution have profound economic and geopolitical implications. It has been demonstrated that, on the scale of glacierized river catchments, land surface hydrological models can successfully simulate glacier contribution to streamflow. However, at global scales, the implementation of glacier melt in hydrological models has been rudimentary or non-existent. In this study, a global glacier mass balance model is coupled with the University of New Hampshire Water Balance/Transport Model (WBM) to assess recent and projected future glacier contributions to the hydrological cycle over the global land surface (excluding the ice sheets of Greenland and Antarctica). For instance, results of WBM simulations indicate that seasonal glacier melt water in many arid climate watersheds comprises 40 % or more of their discharge. Implicitly coupled glacier and WBM models compute monthly glacier mass changes and resulting runoff at the glacier terminus for each individual glacier from the globally complete Randolph Glacier Inventory including over 200 000 glaciers. The time series of glacier runoff is aggregated over each hydrological modeling unit and delivered to the hydrological model for routing downstream and mixing with non-glacial contribution of runoff to each drainage basin outlet. WBM tracks and uses glacial and non-glacial components of the in-stream water for filling reservoirs, transfers of water between

  5. Microchip Screening Platform for Single Cell Assessment of NK Cell Cytotoxicity

    Science.gov (United States)

    Guldevall, Karolin; Brandt, Ludwig; Forslund, Elin; Olofsson, Karl; Frisk, Thomas W.; Olofsson, Per E.; Gustafsson, Karin; Manneberg, Otto; Vanherberghen, Bruno; Brismar, Hjalmar; Kärre, Klas; Uhlin, Michael; Önfelt, Björn

    2016-01-01

    Here, we report a screening platform for assessment of the cytotoxic potential of individual natural killer (NK) cells within larger populations. Human primary NK cells were distributed across a silicon–glass microchip containing 32,400 individual microwells loaded with target cells. Through fluorescence screening and automated image analysis, the numbers of NK and live or dead target cells in each well could be assessed at different time points after initial mixing. Cytotoxicity was also studied by time-lapse live-cell imaging in microwells quantifying the killing potential of individual NK cells. Although most resting NK cells (≈75%) were non-cytotoxic against the leukemia cell line K562, some NK cells were able to kill several (≥3) target cells within the 12-h long experiment. In addition, the screening approach was adapted to increase the chance to find and evaluate serial killing NK cells. Even if the cytotoxic potential varied between donors, it was evident that a small fraction of highly cytotoxic NK cells were responsible for a substantial portion of the killing. We demonstrate multiple assays where our platform can be used to enumerate and characterize cytotoxic cells, such as NK or T cells. This approach could find use in clinical applications, e.g., in the selection of donors for stem cell transplantation or generation of highly specific and cytotoxic cells for adoptive immunotherapy. PMID:27092139

  6. Microchip screening platform for single cell assessment of NK cell cytotoxicity

    Directory of Open Access Journals (Sweden)

    Karolin eGuldevall

    2016-04-01

    Full Text Available Here we report a screening platform for assessment of the cytotoxic potential of individual natural killer (NK cells within larger populations. Human primary NK cells were distributed across a silicon-glass microchip containing 32 400 individual microwells loaded with target cells. Through fluorescence screening and automated image analysis the numbers of NK and live or dead target cells in each well could be assessed at different time points after initial mixing. Cytotoxicity was also studied by time-lapse live-cell imaging in microwells quantifying the killing potential of individual NK cells. Although most resting NK cells (≈75% were non-cytotoxic against the leukemia cell line K562, some NK cells were able to kill several (≥3 target cells within the 12 hours long experiment. In addition, the screening approach was adapted to increase the chance to find and evaluate serial killing NK cells. Even if the cytotoxic potential varied between donors it was evident that a small fraction of highly cytotoxic NK cells were responsible for a substantial portion of the killing. We demonstrate multiple assays where our platform can be used to enumerate and characterize cytotoxic cells, such as NK or T cells. This approach could find use in clinical applications, e.g. in the selection of donors for stem cell transplantation or generation of highly specific and cytotoxic cells for adoptive immunotherapy.

  7. Comparison of Unmanned Aerial Vehicle Platforms for Assessing Vegetation Cover in Sagebrush Steppe Ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Breckenridge; Maxine Dakins; Stephen Bunting; Jerry Harbour; Sera White

    2011-09-01

    In this study, the use of unmanned aerial vehicles (UAVs) as a quick and safe method for monitoring biotic resources was evaluated. Vegetation cover and the amount of bare ground are important factors in understanding the sustainability of many ecosystems and assessment of rangeland health. Methods that improve speed and cost efficiency could greatly improve how biotic resources are monitored on western lands. Sagebrush steppe ecosystems provide important habitat for a variety of species (including sage grouse and pygmy rabbit). Improved methods are needed to support monitoring these habitats because there are not enough resource specialists or funds available for comprehensive ground evaluations. In this project, two UAV platforms, fixed wing and helicopter, were used to collect still-frame imagery to assess vegetation cover in sagebrush steppe ecosystems. This paper discusses the process for collecting and analyzing imagery from the UAVs to (1) estimate percent cover for six different vegetation types (shrub, dead shrub, grass, forb, litter, and bare ground) and (2) locate sage grouse using representative decoys. The field plots were located on the Idaho National Engineering (INL) site west of Idaho Falls, Idaho, in areas with varying amounts and types of vegetation cover. A software program called SamplePoint was used along with visual inspection to evaluate percent cover for the six cover types. Results were compared against standard field measurements to assess accuracy. The comparison of fixed-wing and helicopter UAV technology against field estimates shows good agreement for the measurement of bare ground. This study shows that if a high degree of detail and data accuracy is desired, then a helicopter UAV may be a good platform to use. If the data collection objective is to assess broad-scale landscape level changes, then the collection of imagery with a fixed-wing system is probably more appropriate.

  8. I want what you've got: Cross platform portabiity and human-robot interaction assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Julie L. Marble, Ph.D.*.; Douglas A. Few; David J. Bruemmer

    2005-08-01

    Human-robot interaction is a subtle, yet critical aspect of design that must be assessed during the development of both the human-robot interface and robot behaviors if the human-robot team is to effectively meet the complexities of the task environment. Testing not only ensures that the system can successfully achieve the tasks for which it was designed, but more importantly, usability testing allows the designers to understand how humans and robots can, will, and should work together to optimize workload distribution. A lack of human-centered robot interface design, the rigidity of sensor configuration, and the platform-specific nature of research robot development environments are a few factors preventing robotic solutions from reaching functional utility in real word environments. Often the difficult engineering challenge of implementing adroit reactive behavior, reliable communication, trustworthy autonomy that combines with system transparency and usable interfaces is overlooked in favor of other research aims. The result is that many robotic systems never reach a level of functional utility necessary even to evaluate the efficacy of the basic system, much less result in a system that can be used in a critical, real-world environment. Further, because control architectures and interfaces are often platform specific, it is difficult or even impossible to make usability comparisons between them. This paper discusses the challenges inherent to the conduct of human factors testing of variable autonomy control architectures and across platforms within a complex, real-world environment. It discusses the need to compare behaviors, architectures, and interfaces within a structured environment that contains challenging real-world tasks, and the implications for system acceptance and trust of autonomous robotic systems for how humans and robots interact in true interactive teams.

  9. Assessing lahars from ice-capped volcanoes using ASTER satellite data, the SRTM DTM and two different flow models: case study on Iztaccíhuatl (Central Mexico)

    OpenAIRE

    2008-01-01

    Lahars frequently affect the slopes of ice-capped volcanoes. They can be triggered by volcano-ice interactions during eruptions but also by processes such as intense precipitation or by outbursts of glacial water bodies not directly related to eruptive activity. We use remote sensing, GIS and lahar models in combination with ground observations for an initial lahar hazard assessment on Iztaccíhuatl volcano (5230 m a.s.l.), considering also possible future developments of the glaciers on the v...

  10. Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials

    Directory of Open Access Journals (Sweden)

    Donald C. Aduba

    2017-01-01

    Full Text Available Wound dressings are critical for wound care because they provide a physical barrier between the injury site and outside environment, preventing further damage or infection. Wound dressings also manage and even encourage the wound healing process for proper recovery. Polysaccharide biopolymers are slowly becoming popular as modern wound dressings materials because they are naturally derived, highly abundant, inexpensive, absorbent, non-toxic and non-immunogenic. Polysaccharide biopolymers have also been processed into biomimetic platforms that offer a bioactive component in wound dressings that aid the healing process. This review primarily focuses on the fabrication and biocompatibility assessment of polysaccharide materials. Specifically, fabrication platforms such as electrospun fibers and hydrogels, their fabrication considerations and popular polysaccharides such as chitosan, alginate, and hyaluronic acid among emerging options such as arabinoxylan are discussed. A survey of biocompatibility and bioactive molecule release studies, leveraging polysaccharide’s naturally derived properties, is highlighted in the text, while challenges and future directions for wound dressing development using emerging fabrication techniques such as 3D bioprinting are outlined in the conclusion. This paper aims to encourage further investigation and open up new, disruptive avenues for polysaccharides in wound dressing material development.

  11. The SAMCO Web-platform for resilience assessment in mountainous valleys impacted by landslide risks.

    Science.gov (United States)

    Grandjean, Gilles; Thomas, Loic; Bernardie, Severine

    2016-04-01

    The ANR-SAMCO project aims to develop a proactive resilience framework enhancing the overall resilience of societies on the impacts of mountain risks. The project aims to elaborate methodological tools to characterize and measure ecosystem and societal resilience from an operative perspective on three mountain representative case studies. To achieve this objective, the methodology is split in several points: (1) the definition of the potential impacts of global environmental changes (climate system, ecosystem e.g. land use, socio-economic system) on landslide hazards, (2) the analysis of these consequences in terms of vulnerability (e.g. changes in the location and characteristics of the impacted areas and level of their perturbation) and (3) the implementation of a methodology for quantitatively investigating and mapping indicators of mountain slope vulnerability exposed to several hazard types, and the development of a GIS-based demonstration platform available on the web. The strength and originality of the SAMCO project lies in the combination of different techniques, methodologies and models (multi-hazard assessment, risk evolution in time, vulnerability functional analysis, and governance strategies) that are implemented in a user-oriented web-platform, currently in development. We present the first results of this development task, architecture and functions of the web-tools, the case studies database showing the multi-hazard maps and the stakes at risks. Risk assessment over several area of interest in Alpine or Pyrenean valleys are still in progress, but the first analyses are presented for current and future periods for which climate change and land-use (economical, geographical and social aspects) scenarios are taken into account. This tool, dedicated to stakeholders, should be finally used to evaluate resilience of mountainous regions since multiple scenarios can be tested and compared.

  12. Analysis of snow-cap pollution for air quality assessment in the vicinity of an oil refinery.

    Science.gov (United States)

    Krastinyte, Viktorija; Baltrenaite, Edita; Lietuvninkas, Arvydas

    2013-01-01

    Snow-cap can be used as a simple and effective indicator of industrial air pollution. In this study snow-cap samples were collected from 11 sites located in the vicinity of an oil refinery in Mazeikiai, a region in the north-west of Lithuania, in the winter of 2011. Analysis of snowmelt water and snow-dust was used to determine anthropogenic pollutants such as: sulphates and chlorides, nitrites, nitrates, ammonium nitrogen, total carbon, total nitrogen; heavy metals: lead (Pb), copper (Cu), chromium (Cr), cadmium (Cd). Concentrations of heavy metals in snow-dust were detected thousands of times higher than those in the snowmelt water. In this study, analysis of heavy metal concentration was conducted considering different distances and the wind direction within the impact zone of the oil refinery. The sequence of heavy metals according to their mean concentrations in the snow-dust samples was the following: Pb > Cr > Cu > Cd. Heavy metals highly correlated among each other. The load of snow-dust was evaluated to determine the pollution level in the study area. The highest daily load of snow-dust was 45.81 +/- 12.35 mg/m2 in the north-western direction from the oil refinery. According to classification of the daily load of snow-dust a lower than medium-risk level of pollution was determined in the vicinity of the oil refinery.

  13. Seismic hazard and risk assessment for large Romanian dams situated in the Moldavian Platform

    Science.gov (United States)

    Moldovan, Iren-Adelina; Popescu, Emilia; Otilia Placinta, Anica; Petruta Constantin, Angela; Toma Danila, Dragos; Borleanu, Felix; Emilian Toader, Victorin; Moldoveanu, Traian

    2016-04-01

    Besides periodical technical inspections, the monitoring and the surveillance of dams' related structures and infrastructures, there are some more seismic specific requirements towards dams' safety. The most important one is the seismic risk assessment that can be accomplished by rating the dams into seismic risk classes using the theory of Bureau and Ballentine (2002), and Bureau (2003), taking into account the maximum expected peak ground motions at the dams site - values obtained using probabilistic hazard assessment approaches (Moldovan et al., 2008), the structures vulnerability and the downstream risk characteristics (human, economical, historic and cultural heritage, etc) in the areas that might be flooded in the case of a dam failure. Probabilistic seismic hazard (PSH), vulnerability and risk studies for dams situated in the Moldavian Platform, starting from Izvorul Muntelui Dam, down on Bistrita and following on Siret River and theirs affluent will be realized. The most vulnerable dams will be studied in detail and flooding maps will be drawn to find the most exposed downstream localities both for risk assessment studies and warnings. GIS maps that clearly indicate areas that are potentially flooded are enough for these studies, thus giving information on the number of inhabitants and goods that may be destroyed. Geospatial servers included topography is sufficient to achieve them, all other further studies are not necessary for downstream risk assessment. The results will consist of local and regional seismic information, dams specific characteristics and locations, seismic hazard maps and risk classes, for all dams sites (for more than 30 dams), inundation maps (for the most vulnerable dams from the region) and possible affected localities. The studies realized in this paper have as final goal to provide the local emergency services with warnings of a potential dam failure and ensuing flood as a result of an large earthquake occurrence, allowing further

  14. Accuracy Assessment of Direct Georeferencing for Photogrammetric Applications on Small Unmanned Aerial Platforms

    Science.gov (United States)

    Mian, O.; Lutes, J.; Lipa, G.; Hutton, J. J.; Gavelle, E.; Borghini, S.

    2016-03-01

    Microdrones md4-1000 quad-rotor VTOL UAV. The Sony A7R and each lens combination were focused and calibrated terrestrially using the Applanix camera calibration facility, and then integrated with the APX-15 GNSS-Inertial system using a custom mount specifically designed for UAV applications. The mount is constructed in such a way as to maintain the stability of both the interior orientation and IMU boresight calibration over shock and vibration, thus turning the Sony A7R into a metric imaging solution. In July and August 2015, Applanix and Avyon carried out a series of test flights of this system. The goal of these test flights was to assess the performance of DMS APX-15 direct georeferencing system under various scenarios. Furthermore, an examination of how DMS APX-15 can be used to produce accurate map products without the use of ground control points and with reduced sidelap was also carried out. Reducing the side lap for survey missions performed by small UAVs can significantly increase the mapping productivity of these platforms. The area mapped during the first flight campaign was a 250m x 300m block and a 775m long railway corridor in a rural setting in Ontario, Canada. The second area mapped was a 450m long corridor over a dam known as Fryer Dam (over Richelieu River in Quebec, Canada). Several ground control points were distributed within both test areas. The flight over the block area included 8 North-South lines and 1 cross strip flown at 80m AGL, resulting in a ~1cm GSD. The flight over the railway corridor included 2 North-South lines also flown at 80m AGL. Similarly, the flight over the dam corridor included 2 North-South lines flown at 50m AGL. The focus of this paper was to analyse the results obtained from the two corridors. Test results from both areas were processed using Direct Georeferencing techniques, and then compared for accuracy against the known positions of ground control points in each test area. The GNSS-Inertial data collected by the APX-15 was

  15. A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

    Science.gov (United States)

    Koopman, Mandy; Michels, Helen; Dancy, Beverley M; Kamble, Rashmi; Mouchiroud, Laurent; Auwerx, Johan; Nollen, Ellen A A; Houtkooper, Riekelt H

    2016-10-01

    Mitochondrial dysfunction is at the core of many diseases ranging from inherited metabolic diseases to common conditions that are associated with aging. Although associations between aging and mitochondrial function have been identified using mammalian models, much of the mechanistic insight has emerged from Caenorhabditis elegans. Mitochondrial respiration is recognized as an indicator of mitochondrial health. The Seahorse XF96 respirometer represents the state-of-the-art platform for assessing respiration in cells, and we adapted the technique for applications involving C. elegans. Here we provide a detailed protocol to optimize and measure respiration in C. elegans with the XF96 respirometer, including the interpretation of parameters and results. The protocol takes ∼2 d to complete, excluding the time spent culturing C. elegans, and it includes (i) the preparation of C. elegans samples, (ii) selection and loading of compounds to be injected, (iii) preparation and execution of a run with the XF96 respirometer and (iv) postexperimental data analysis, including normalization. In addition, we compare our XF96 application with other existing techniques, including the eight-well Seahorse XFp. The main benefits of the XF96 include the limited number of worms required and the high throughput capacity due to the 96-well format.

  16. An integrated telemedicine platform for the assessment of affective physiological states.

    Science.gov (United States)

    Katsis, Christos D; Ganiatsas, George; Fotiadis, Dimitrios I

    2006-08-01

    AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a) a multisensorial wearable, (b) a data acquisition and wireless communication module, (c) a feature extraction module, (d) a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model; whereas the end-user will be able to view the facial expression of the subject in real time, (e) an intelligent emotion recognition module, and (f) the AUBADE databases where the acquired signals along with the subject's animation videos are saved. The system is designed to be applied to human subjects operating under extreme stress conditions, in particular car racing drivers, and also to patients suffering from neurological and psychological disorders. AUBADE's classification accuracy into five predefined emotional classes (high stress, low stress, disappointment, euphoria and neutral face) is 86.0%. The pilot system applications and components are being tested and evaluated on Maserati's car racing drivers.

  17. An integrated telemedicine platform for the assessment of affective physiological states

    Directory of Open Access Journals (Sweden)

    Ganiatsas George

    2006-08-01

    Full Text Available Abstract AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a a multisensorial wearable, (b a data acquisition and wireless communication module, (c a feature extraction module, (d a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model; whereas the end-user will be able to view the facial expression of the subject in real time, (e an intelligent emotion recognition module, and (f the AUBADE databases where the acquired signals along with the subject's animation videos are saved. The system is designed to be applied to human subjects operating under extreme stress conditions, in particular car racing drivers, and also to patients suffering from neurological and psychological disorders. AUBADE's classification accuracy into five predefined emotional classes (high stress, low stress, disappointment, euphoria and neutral face is 86.0%. The pilot system applications and components are being tested and evaluated on Maserati's car. racing drivers.

  18. Development of a Micro-UAV Hyperspectral Imaging Platform for Assessing Hydrogeological Hazards

    Science.gov (United States)

    Chen, Z.; Alabsi, M.

    2015-12-01

    The exacerbating global weather changes have cast significant impacts upon the proportion of water supplied to agriculture. Therefore, one of the 21stCentury Grant Challenges faced by global population is securing water for food. However, the soil-water behavior in an agricultural environment is complex; among others, one of the key properties we recognize is water repellence or hydrophobicity, which affects many hydrogeological and hazardous conditions such as excessive water infiltration, runoff, and soil erosion. Under a US-Israel research program funded by USDA and BARD at Israel, we have proposed the development of a novel micro-unmanned aerial vehicle (micro-UAV or drone) based hyperspectral imaging platform for identifying and assessing soil repellence at low altitudes with enhanced flexibility, much reduced cost, and ultimately easy use. This aerial imaging system consists of a generic micro-UAV, hyperspectral sensor aided by GPS/IMU, on-board computing units, and a ground station. The target benefits of this system include: (1) programmable waypoint navigation and robotic control for multi-view imaging; (2) ability of two- or three-dimensional scene reconstruction for complex terrains; and (3) fusion with other sensors to realize real-time diagnosis (e.g., humidity and solar irradiation that may affect soil-water sensing). In this talk we present our methodology and processes in integration of hyperspectral imaging, on-board sensing and computing, hyperspectral data modeling, and preliminary field demonstration and verification of the developed prototype.

  19. Flow cytometric scoring of micronucleated erythrocytes: an efficient platform for assessing in vivo cytogenetic damage.

    Science.gov (United States)

    Dertinger, Stephen D; Torous, Dorothea K; Hayashi, Makoto; MacGregor, James T

    2011-01-01

    The relative simplicity of the micronucleated erythrocyte endpoint has made it amenable to automated scoring approaches. Flow cytometry is one such scoring platform that has been employed successfully. This review describes the evolution and properties of flow cytometry-based scoring of micronucleated erythrocytes. The methodology has become widely applied to rodent blood specimens and the high throughput nature of the technology provides a number of advantages over manual microscopic scoring. For instance, the ability to efficiently survey many dose levels and many more cells per specimen relative to microscopy benefits studies that are designed to identify no observable effect levels or lowest observable effect levels. Furthermore, flow cytometry makes it practical to study species with low spontaneous reticulocyte (RET) counts and micronucleus (MN) frequencies, thereby facilitating integration of blood-based micronucleated reticulocyte (MN-RET) frequency measurements into experiments conducted across species of toxicological interest. This capability enhances genotoxicity assessments that have historically been made in dedicated MN tests performed in one species. Importantly, the feasibility of using MN-RET frequencies in blood from humans as an index of genetic damage in bone marrow opens a critical area of application that had not been practical previously. We conclude with recommendations for additional work that is needed to more fully realise the potential of flow cytometric in vivo MN scoring.

  20. A systematic assessment of normalization approaches for the Infinium 450K methylation platform.

    Science.gov (United States)

    Wu, Michael C; Joubert, Bonnie R; Kuan, Pei-fen; Håberg, Siri E; Nystad, Wenche; Peddada, Shyamal D; London, Stephanie J

    2014-02-01

    The Illumina Infinium HumanMethylation450 BeadChip has emerged as one of the most popular platforms for genome wide profiling of DNA methylation. While the technology is wide-spread, systematic technical biases are believed to be present in the data. For example, this array incorporates two different chemical assays, i.e., Type I and Type II probes, which exhibit different technical characteristics and potentially complicate the computational and statistical analysis. Several normalization methods have been introduced recently to adjust for possible biases. However, there is considerable debate within the field on which normalization procedure should be used and indeed whether normalization is even necessary. Yet despite the importance of the question, there has been little comprehensive comparison of normalization methods. We sought to systematically compare several popular normalization approaches using the Norwegian Mother and Child Cohort Study (MoBa) methylation data set and the technical replicates analyzed with it as a case study. We assessed both the reproducibility between technical replicates following normalization and the effect of normalization on association analysis. Results indicate that the raw data are already highly reproducible, some normalization approaches can slightly improve reproducibility, but other normalization approaches may introduce more variability into the data. Results also suggest that differences in association analysis after applying different normalizations are not large when the signal is strong, but when the signal is more modest, different normalizations can yield very different numbers of findings that meet a weaker statistical significance threshold. Overall, our work provides useful, objective assessment of the effectiveness of key normalization methods.

  1. GeoProMT: A Collaborative Platform Supporting Natural Hazards Project Management From Assessment to Resilience

    Science.gov (United States)

    Renschler, C.; Sheridan, M. F.; Patra, A. K.

    2008-05-01

    The impact and consequences of extreme geophysical events (hurricanes, floods, wildfires, volcanic flows, mudflows, etc.) on properties and processes should be continuously assessed by a well-coordinated interdisciplinary research and outreach approach addressing risk assessment and resilience. Communication between various involved disciplines and stakeholders is the key to a successful implementation of an integrated risk management plan. These issues become apparent at the level of decision support tools for extreme events/disaster management in natural and managed environments. The Geospatial Project Management Tool (GeoProMT) is a collaborative platform for research and training to document and communicate the fundamental steps in transforming information for extreme events at various scales for analysis and management. GeoProMT is an internet-based interface for the management of shared geo-spatial and multi-temporal information such as measurements, remotely sensed images, and other GIS data. This tool enhances collaborative research activities and the ability to assimilate data from diverse sources by integrating information management. This facilitates a better understanding of natural processes and enhances the integrated assessment of resilience against both the slow and fast onset of hazard risks. Fundamental to understanding and communicating complex natural processes are: (a) representation of spatiotemporal variability, extremes, and uncertainty of environmental properties and processes in the digital domain, (b) transformation of their spatiotemporal representation across scales (e.g. interpolation, aggregation, disaggregation.) during data processing and modeling in the digital domain, and designing and developing tools for (c) geo-spatial data management, and (d) geo-spatial process modeling and effective implementation, and (e) supporting decision- and policy-making in natural resources and hazard management at various spatial and temporal scales

  2. Assessment of USDA-NRCS rangeland conservation programs: recommendation for an evidence-based conservation platform.

    Science.gov (United States)

    Briske, D D; Bestelmeyer, B T; Brown, J R; Brunson, M W; Thurow, T L; Tanaka, J A

    2017-01-01

    The Conservation Effects Assessment Project (CEAP) was created in response to a request from the Office of Management and Budget that the U.S. Department of Agriculture, Natural Resource Conservation Service (USDA-NRCS) document the societal benefits anticipated to accrue from a major increase in conservation funding authorized by the 2002 Farm Bill. A comprehensive evaluation of the efficacy of rangeland conservation practices cost-shared with private landowners was unable to evaluate conservation benefits because outcomes were seldom documented. Four interrelated suppositions are presented to examine the causes underlying minimal documentation of conservations outcomes. These suppositions are (1) the benefits of conservation practices are considered a certainty so that documentation in not required, (2) there is minimal knowledge exchange between the USDA-NRCS and research organizations, (3) and a paucity of conservation-relevant science, as well as (4) inadequate technical support for land owners following implementation of conservation practices. We then follow with recommendations to overcome potential barriers to documentation of conservation outcomes identified for each supposition. Collectively, this assessment indicates that the existing conservation practice standards are insufficient to effectively administer large conservation investments on rangelands and that modification of these standards alone will not achieve the goals explicitly stated by CEAP. We recommend that USDA-NRCS modify its conservation programs around a more comprehensive and integrative platform that is capable of implementing evidence-based conservation. Collaborative monitoring organized around landowner-agency-scientist partnerships would represent the focal point of a Conservation Program Assessment Network (CPAN). The primary network objective would be to establish missing information feedback loops between conservation practices and their agricultural and environmental outcomes

  3. Towards Supporting Climate Scientists and Impact Assessment Analysts with the Big Data Europe Platform

    Science.gov (United States)

    Klampanos, Iraklis; Vlachogiannis, Diamando; Andronopoulos, Spyros; Cofiño, Antonio; Charalambidis, Angelos; Lokers, Rob; Konstantopoulos, Stasinos; Karkaletsis, Vangelis

    2016-04-01

    The EU, Horizon 2020, project Big Data Europe (BDE) aims to support European companies and institutions in effectively managing and making use of big data in activities critical to their progress and success. BDE focuses on seven areas of societal impact: Health, Food and Agriculture, Energy, Transport, Climate, Social Sciences and Security. By reaching out to partners and stakeholders, BDE aims to elicit data-intensive requirements for, and deliver an ICT platform to cover aspects of publishing and consuming semantically interoperable, large-scale, multi-lingual data assets and knowledge. In this presentation we will describe the first BDE pilot for Climate, focusing on SemaGrow, its core component, which provides data querying and management based on data semantics. Over the last few decades, extended scientific effort in understanding climate change has resulted in a huge volume of model and observational data. Large international global and regional model inter-comparison projects have focused on creating a framework in support of climate model diagnosis, validation, documentation and data access. The application of climate model ensembles, a system consisting of different possible realisations of a climate model, has further significantly increased the amount of climate and weather data generated. The provision of such models satisfies the crucial objective of assessing potential impacts of climate change on well-being for adaptation, prevention and mitigation. One of the methodologies applied by the climate research and impact assessment communities is that of dynamical downscaling. This calculates values of atmospheric variables in smaller spatial and temporal scales, given a global model. On the company or institution level, this process can be greatly improved in terms of querying, data ingestion from various sources and formats, automatic data mapping, etc. The first Climate BDE pilot will facilitate the process of dynamical downscaling by providing a

  4. Polar Cap Patch Dynamics

    Science.gov (United States)

    2013-04-25

    cap arcs Citation: Hosokawa, K., J. I. Moen, K. Shiokawa, and Y. Otsuka ( 2011 ), Motion of polar cap arcs , J. Geophys. Res. , 116 , A01305, doi...K., J. I. Moen, K. Shiokawa, and Y. Otsuka , (2011), Decay of polar cap patch, J. Geophys. Res., 116, A05308, doi:10.1029/2010JA016287, Abstract. We

  5. The North Zealand CAP Monitor

    DEFF Research Database (Denmark)

    Nielsen, Minna; Ravn, Pernille; Notander Clausen, Lise

    Contect We describe how we developed a monitoring system for community acquired pneumonia (CAP) at North Zealand Regional hospital. We serve 310.000 inhabitants and annually around 3200 patients with CAP are admitted. As part of a program of clinical pathways for common conditions, a pathway...... for pneumonia was designed and implemented in 2010. Problem In spite of our clinical pathway for CAP we found delays in start of treatment, overuse of antibiotics and long length of stay (LOS). Mortality was nearly 20 %. Assessment of problem and analysis of its causes We established an audit group of two...... nurses and two senior doctors. Direct observations of the clinical processes revealed problems of coordination, complex disease trajectories that did not fit with the pneumonia pathway, unclear guidelines and variation in their interpretation. Intervention We designed a measurement system to monitor...

  6. Evaporites on Ice: Experimental Assessment of Evaporites Formation on Antarctica (and on Martian North Polar Residual Cap)

    Science.gov (United States)

    Losiak, Anna; Derkowski, Arkadiusz; Skala, Aleksander; Trzcinski, Jerzy

    2016-04-01

    Evaporites are highly water soluble minerals, formed as a result of the evaporation or freezing of bodies of water. They are common weathering minerals found on rocks (including meteorites) on Antarctic ice sheet [1,2,3,4]. The water necessary for the reaction is produced by melting of ice below the dark-colored meteorites which can heat up to a few degrees above 0 °C due to insolation heating during wind-free summer days [5,6]. The Martian North Polar Residual Cap is surrounded by a young [7] dune field that is rich in evaporitic mineral: gypsum [8]. Its existence implies that relatively recently in the Martian history (in late Amazonian, when surface conditions were comparable to the current ones) there was a significant amount of liquid water present on the Mars surface. One of the proposed solutions to this problem is that gypsum is formed by weathering on/in ice [9,10,11,12,13], similarly to the process occurring on the Antarctic ice sheet. Recently, Losiak et al. 2015 showed that that during the warmest days of the Martian summer, solar irradiation may be sufficient to melt pure water ice located below a layer of dark dust particles lying on the steepest sections of the equator-facing slopes of the spiral troughs within Martian NPRC. Under the current irradiation conditions, melting is possible in very restricted areas of the NPRC and it lasts for up to couple of hours, but during the times of high irradiance at the north pole [15] this process could have been much more pronounced. Liquid water can be metastable at the NPRC because the pressure during the summer season is ~760-650 Pa [16] which is above the triple point of water. The rate of free-surface "clean" liquid water evaporation under average Martian conditions determined experimentally by [17] is comparable to the rate of melting determined by [21] (if there is no wind at the surface). In the current study we attempt to determine experimentally how many melting-freezing cycles are required to form

  7. Application of a Dot Blot Hybridization Platform to Assess Streptococcus uberis Population Structure in Dairy Herds

    Science.gov (United States)

    Albuquerque, Pedro; Ribeiro, Niza; Almeida, Alexandre; Panschin, Irena; Porfirio, Afonso; Vales, Marta; Diniz, Francisca; Madeira, Helena; Tavares, Fernando

    2017-01-01

    Streptococcus uberis is considered one of the most important pathogens associated with bovine mastitis. While traditionally acknowledged as an environmental pathogen, S. uberis has been shown to adopt a contagious epidemiological pattern in several dairy herds. Since different control strategies are employed depending on the mode of transmission, in-depth studies of S. uberis populations are essential to determine the best practices to control this pathogen. In this work, we optimized and validated a dot blot platform, combined with automatic image analysis, to rapidly assess the population structure of infective S. uberis, and evaluated its efficiency when compared to multilocus sequence analysis (MLSA) genotyping. Two dairy herds with prevalent S. uberis infections were followed in a 6 month period, in order to collect and characterize isolates from cows with persistent infections. These herds, located in Portugal (Barcelos and Maia regions), had similar management practices, with the herd from Barcelos being smaller and having a better milking parlor management, since infected cow segregation was immediate. A total of 54 S. uberis isolates were obtained from 24 different cows from the two herds. To overcome operator-dependent analysis of the dot blots and increase the technique's consistency and reliability, the hybridization signals were converted into probability values, with average probabilities higher than 0.5 being considered positive results. These data allowed to confirm the isolates' identity as S. uberis using taxa-specific markers and to determine the presence of virulence- and antibiotic resistance-related genes. In addition, MLSA allowed to disclose the most prevalent S. uberis clonal lineages in both herds. Seven different clusters were identified, with Barcelos showing a high clonal diversity and Maia a dominant lineage infecting most cows, suggesting distinct epidemiological patterns, with S. uberis displaying an environmental or contagious

  8. Whole-body isometric force/torque measurements for functional assessment in neuro-rehabilitation: platform design, development and verification

    Directory of Open Access Journals (Sweden)

    Cavallo Giuseppe

    2009-10-01

    Full Text Available Abstract Background One of the main scientific and technological challenges of rehabilitation bioengineering is the development of innovative methodologies, based on the use of appropriate technological devices, for an objective assessment of patients undergoing a rehabilitation treatment. Such tools should be as fast and cheap to use as clinical scales, which are currently the daily instruments most widely used in the routine clinical practice. Methods A human-centered approach was used in the design and development of a mechanical structure equipped with eight force/torque sensors that record quantitative data during the initiation of a predefined set of Activities of Daily Living (ADL tasks, in isometric conditions. Results Preliminary results validated the appropriateness, acceptability and functionality of the proposed platform, that has become now a tool used for clinical research in three clinical centres. Conclusion This paper presented the design and development of an innovative platform for whole-body force and torque measurements on human subjects. The platform has been designed to perform accurate quantitative measurements in isometric conditions with the specific aim to address the needs for functional assessment tests of patients undergoing a rehabilitation treatment as a consequence of a stroke. The versatility of the system also enlightens several other interesting possible areas of application for therapy in neurorehabilitation, for research in basic neuroscience, and more.

  9. Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment

    NARCIS (Netherlands)

    Percy, Andrew J.; Tamura-Wells, Jessica; Albar, Juan Pablo; Aloria, Kerman; Amirkhani, Ardeshir; Araujo, Gabriel D T; Arizmendi, Jesus M.; Blanco, Francisco J.; Canals, Francesc; Cho, Jin Young; Colomé-Calls, Núria; Corrales, Fernando J.; Domont, Gilberto; Espadas, Guadalupe; Fernandez-Puente, Patricia; Gil, Concha; Haynes, Paul A.; Hernáez, Maria Luisa; Kim, Jin Young; Kopylov, Arthur; Marcilla, Miguel; McKay, Mathew J.; Mirzaei, Mehdi; Molloy, Mark P.; Ohlund, Leanne B.; Paik, Young Ki; Paradela, Alberto; Raftery, Mark; Sabidó, Eduard; Sleno, Lekha; Wilffert, Daniel; Wolters, Justina C.; Yoo, Jong Shin; Zgoda, Victor; Parker, Carol E.; Borchers, Christoph H.

    2015-01-01

    The reproducibility of plasma protein quantitation between laboratories and between instrument types was examined in a large-scale international study involving 16 laboratories and 19 LC-MS/MS platforms, using two kits designed to evaluate instrument performance and one kit designed to evaluate the

  10. Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases

    Institute of Scientific and Technical Information of China (English)

    Tan Jiping; Li Nan; Gao Jing; Guo Yuhe; Hu Wei; Yang Jinsheng; Yu Baocheng

    2014-01-01

    Background Based on the excellent medical care and management system for Chinese veterans,as well as the detailed medical documentation available,we aim to construct a Chinese Veteran Clinical Research (CVCR) platform on noncommunicable diseases (NCDs) and carry out studies of the primary disabling NCDs.Methods The Geriatric Neurology Department of Chinese People's Liberation Army General Hospital and veterans' hospitals serve as the leading and participating units in the platform construction.The fundamental constituents of the platform are veteran communities.Stratified typical cluster sampling is adopted to recruit veteran communities.A cross-sectional study of mental,neurological,and substance use (MNS) disorders are performed in two stages using screening scale such as the Mini-Mental State Examination and Montreal cognitive assessment,followed by systematic neuropsychological assessments to make clinical diagnoses,evaluated disease awareness and care situation.Results A total of 9 676 among 277 veteran communities from 18 cities are recruited into this platform,yielding a response rate of 83.86%.8 812 subjects complete the MNS subproject screening and total response rate is 91.70%.The average participant age is (82.01±4.61) years,69.47% of veterans are 80 years or older.Most participants are male (94.01%),83.36% of subjects have at least a junior high school degree.The overall health status of veterans is good and stable.The most common NCD are cardiovascular disorders (86.44%),urinary and genital diseases (73.14%),eye and ear problems (66.25%),endocrine (56.56%) and neuro-psychiatric disturbances (50.78%).Conclusion We first construct a veterans' comprehensive clinical research platform for the study of NCDs that is primarily composed of highly educated Chinese males of advanced age and utilize this platform to complete a cross-sectional national investigation of MNS disorders among veterans.The good and stable health condition of the

  11. GPS/CAPS dual-mode software receiver

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The positioning of the GPS or Chinese Area Positioning System (CAPS) software receiver was developed on a software receiver platform. The structure of the GPS/CAPS dual-mode software receiver was put forward after analyzing the differences in the satellite identification, ranging code, spread spectrum, coordinate system, time system, carrier band, and navigation data between GPS and CAPS. Based on Matlab software on a personal computer, baseband signal processing and positioning procedures were completed using real GPS and CAPS radio frequency signals received by two antennas. Three kinds of experiments including GPS positioning, CAPS positioning, and GPS/CAPS positioning were carried out. Stability and precision of the results were analyzed and compared. The experimental results show that the precision of CAPS is similar to that of GPS, while the positioning precision of the GPS/CAPS dual-mode software receiver is 1-2 m higher than that of CAPS or GPS. The smallest average variance of the positioning can be obtained by using the GPS/CAPS dual-mode software receiver.

  12. GPS/CAPS dual-mode software receiver

    Institute of Scientific and Technical Information of China (English)

    NING ChunLin; SHI HuLi; HU Chao

    2009-01-01

    The positioning of the GPS or Chinese Area Positioning System (CAPS) software receiver was developed on a software receiver platform.The structure of the GPSlCAPS dual-mode software receiver was put forward after analyzing the differences in the satellite identification,ranging code,spread spectrum,coordinate system,time system,carrier band,and navigation data between GPS and CAPS.Based on Matlab software on a personal computer,baseband signal processing and positioning procedures were completed using real GPS and CAPS radio frequency signals received by two antennas.Three kinds of experiments including GPS positioning,CAPS positioning,and GPS/CAPS positioning were carried out.Stability and precision of the results were analyzed and compared.The experimental results show that the precision of CAPS is similar to that of GPS,while the positioning precision of the GPS/CAPS dual-mode software receiver is 1-2 m higher than that of CAPS or GPS.The smallest average variance of the positioning can be obtained by using the GPS/CAPS dual-mode software receiver.

  13. Platform Li-Ion Battery Risk Assessment Tool: Cooperative Research and Development Final Report, CRADA Number CRD-10-407

    Energy Technology Data Exchange (ETDEWEB)

    Smith, K.

    2012-01-01

    Creare was awarded a Phase 1 STTR contract from the US Office of Naval Research, with a seven month period of performance from 6/28/2010 to 1/28/2011. The objectives of the STTR were to determine the feasibility of developing a software package for estimating reliability of battery packs, and develop a user interface to allow the designer to assess the overall impact on battery packs and host platforms for cell-level faults. NREL served as sub-tier partner to Creare, providing battery modeling and battery thermal safety expertise.

  14. Microtubule's conformational cap

    DEFF Research Database (Denmark)

    Chretien, D.; Janosi, I.; Taveau, J.C.

    1999-01-01

    The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called "GTP-cap". Here, we point-out that the elastic properties...

  15. Blu-Ray-based micromechanical characterization platform for biopolymer degradation assessment

    DEFF Research Database (Denmark)

    Casci Ceccacci, Andrea; Chen, Ching-Hsiu; Hwu, En-Te

    2017-01-01

    Degradable biopolymers are used as carrier materials in drug delivery devices. A complete understanding of their degradation behaviour is thus crucial in the design of new delivery systems. Here we combine a reliable method, based on spray coated micromechanical resonators and a disposable...... microfluidic chip, to characterize biopolymer degradation under the action of enzymes in controlled flow condition. The sensing platform is based on the mechanics and optics from a Blu-Ray player, which automatically localize individual sensors within the array, and sequentially measure and record...

  16. Web-Based Portfolio Assessment: Validation of an Open Source Platform

    Science.gov (United States)

    Collins, Regina; Elliot, Norbert; Klobucar, Andrew; Deek, Fadi P.

    2013-01-01

    Assessment of educational outcomes through purchased tests is commonplace in the evaluation of individual student ability and of educational programs. Focusing on the assessment of writing performance in a longitudinal study of first-time, full-time students (n = 598), this research describes the design, use, and assessment of an open-source…

  17. Wearable Textile Platform for Assessing Stroke Patient Treatment in Daily Life Conditions.

    Science.gov (United States)

    Lorussi, Federico; Carbonaro, Nicola; De Rossi, Danilo; Paradiso, Rita; Veltink, Peter; Tognetti, Alessandro

    2016-01-01

    Monitoring physical activities during post-stroke rehabilitation in daily life may help physicians to optimize and tailor the training program for patients. The European research project INTERACTION (FP7-ICT-2011-7-287351) evaluated motor capabilities in stroke patients during the recovery treatment period. We developed wearable sensing platform based on the sensor fusion among inertial, knitted piezoresistive sensors and textile EMG electrodes. The device was conceived in modular form and consists of a separate shirt, trousers, glove, and shoe. Thanks to the novel fusion approach it has been possible to develop a model for the shoulder taking into account the scapulo-thoracic joint of the scapular girdle, considerably improving the estimation of the hand position in reaching activities. In order to minimize the sensor set used to monitor gait, a single inertial sensor fused with a textile goniometer proved to reconstruct the orientation of all the body segments of the leg. Finally, the sensing glove, endowed with three textile goniometers and three force sensors showed good capabilities in the reconstruction of grasping activities and evaluating the interaction of the hand with the environment, according to the project specifications. This paper reports on the design and the technical evaluation of the performance of the sensing platform, tested on healthy subjects.

  18. Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis

    Directory of Open Access Journals (Sweden)

    Iraola Susana

    2011-06-01

    Full Text Available Abstract Background Epidermal Growth Factor (EGF is a key regulatory growth factor activating many processes relevant to normal development and disease, affecting cell proliferation and survival. Here we use a combined approach to study the EGF dependent transcriptome of HeLa cells by using multiple long oligonucleotide based microarray platforms (from Agilent, Operon, and Illumina in combination with digital gene expression profiling (DGE with the Illumina Genome Analyzer. Results By applying a procedure for cross-platform data meta-analysis based on RankProd and GlobalAncova tests, we establish a well validated gene set with transcript levels altered after EGF treatment. We use this robust gene list to build higher order networks of gene interaction by interconnecting associated networks, supporting and extending the important role of the EGF signaling pathway in cancer. In addition, we find an entirely new set of genes previously unrelated to the currently accepted EGF associated cellular functions. Conclusions We propose that the use of global genomic cross-validation derived from high content technologies (microarrays or deep sequencing can be used to generate more reliable datasets. This approach should help to improve the confidence of downstream in silico functional inference analyses based on high content data.

  19. Wearable textile platform for assessing stroke patient treatment in daily life conditions

    Directory of Open Access Journals (Sweden)

    Federico eLorussi

    2016-03-01

    Full Text Available Monitoring physical activities during post-stroke rehabilitation in daily life may help physicians to optimize and tailor the training program for patients. The European research project INTERACTION (FP7-ICT-2011-7-287351 evaluated motor capabilities in stroke patients during the recovery treatment period. We developed wearable sensing platform based on the sensor fusion among inertial, knitted piezoresistive sensors and textile EMG electrodes . The device was conceived in modular form and consists of a separate shirt, trousers, glove and shoe. Thanks to the novel fusion approach it has been possible to develop a model for the shoulder taking into account the scapulo-thoracic joint of the scapular girdle, considerably improving the estimation of the hand position in reaching activities. In order to minimize the sensor set used to monitor gait, a single inertial sensor fused with a textile goniometer proved to reconstruct the orientation of all the body segments of the leg. Finally, the sensing glove, endowed with three textile goniometers and three force sensors showed good capabilities in the reconstruction of grasping activities and evaluating the interaction of the hand with the environment, according to the project specifications. This paper reports on the design and the technical evaluation of the performance of the sensing platform, tested on healthy subjects.

  20. Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment

    Directory of Open Access Journals (Sweden)

    Andrew J. Percy

    2015-09-01

    Full Text Available The reproducibility of plasma protein quantitation between laboratories and between instrument types was examined in a large-scale international study involving 16 laboratories and 19 LC–MS/MS platforms, using two kits designed to evaluate instrument performance and one kit designed to evaluate the entire bottom-up workflow. There was little effect of instrument type on the quality of the results, demonstrating the robustness of LC/MRM-MS with isotopically labeled standards. Technician skill was a factor, as errors in sample preparation and sub-optimal LC–MS performance were evident. This highlights the importance of proper training and routine quality control before quantitation is done on patient samples.

  1. The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

    Science.gov (United States)

    Attene-Ramos, Matias S; Miller, Nicole; Huang, Ruili; Michael, Sam; Itkin, Misha; Kavlock, Robert J; Austin, Christopher P; Shinn, Paul; Simeonov, Anton; Tice, Raymond R; Xia, Menghang

    2013-08-01

    Since its establishment in 2008, the US Tox21 inter-agency collaboration has made great progress in developing and evaluating cellular models for the evaluation of environmental chemicals as a proof of principle. Currently, the program has entered its production phase (Tox21 Phase II) focusing initially on the areas of modulation of nuclear receptors and stress response pathways. During Tox21 Phase II, the set of chemicals to be tested has been expanded to nearly 10,000 (10K) compounds and a fully automated screening platform has been implemented. The Tox21 robotic system combined with informatics efforts is capable of screening and profiling the collection of 10K environmental chemicals in triplicate in a week. In this article, we describe the Tox21 screening process, compound library preparation, data processing, and robotic system validation.

  2. Cradle Cap (For Parents)

    Science.gov (United States)

    ... is the common term for seborrheic dermatitis , or seborrhea, which is called dandruff in older kids and ... another factor in the development of cradle cap. Seborrhea happens most often in babies and teenagers. In ...

  3. Novel data visualizations of X-ray data for aviation security applications using the Open Threat Assessment Platform (OTAP)

    Science.gov (United States)

    Gittinger, Jaxon M.; Jimenez, Edward S.; Holswade, Erica A.; Nunna, Rahul S.

    2017-02-01

    This work will demonstrate the implementation of a traditional and non-traditional visualization of x-ray images for aviation security applications that will be feasible with open system architecture initiatives such as the Open Threat Assessment Platform (OTAP). Anomalies of interest to aviation security are fluid, where characteristic signals of anomalies of interest can evolve rapidly. OTAP is a limited scope open architecture baggage screening prototype that intends to allow 3rd-party vendors to develop and easily implement, integrate, and deploy detection algorithms and specialized hardware on a field deployable screening technology [13]. In this study, stereoscopic images were created using an unmodified, field-deployed system and rendered on the Oculus Rift, a commercial virtual reality video gaming headset. The example described in this work is not dependent on the Oculus Rift, and is possible using any comparable hardware configuration capable of rendering stereoscopic images. The depth information provided from viewing the images will aid in the detection of characteristic signals from anomalies of interest. If successful, OTAP has the potential to allow for aviation security to become more fluid in its adaptation to the evolution of anomalies of interest. This work demonstrates one example that is easily implemented using the OTAP platform, that could lead to the future generation of ATR algorithms and data visualization approaches.

  4. Fish survey, fishing duration, shellfish resource assessment, and other data from the COMMANDO and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 21 May 1976 to 16 September 1976 (NODC Accession 7700432)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish survey, fishing duration, shellfish resource assessment, and other data were collected from the COMMANDO and other platforms from 21 May 1976 to 16 September...

  5. Adsorption kinetics of pesticide in soil assessed by optofluidics-based biosensing platform.

    Science.gov (United States)

    Long, Feng; Zhu, Anna; Shi, Hanchang; Sheng, Jianwu; Zhao, Zhen

    2015-02-01

    The adsorption of pesticides in soil is a key process that affects transport, degradation, mobility, and bioaccumulation of these substances. To obtain extensive knowledge regarding the adsorption processes of pesticides in the environment, the new green assay technologies for the rapid, sensitive, field-deployable, and accurate quantification of pesticides are required. In the present study, an evanescent wave-based optofluidics biosensing platform (EWOB) was developed by combining advanced photonics and microfluidics technology for the rapid sensitive immunodetection and adsorption kinetics assay of pesticides. The robustness, reusability, and accuracy of the EWOB allow an enhanced prediction of pesticide adsorption kinetics in soil. Using atrazine (ATZ) as the target model, we found that the adsorption kinetics in soil followed a pseudo-second-order kinetic model. EWOB was compared with liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method and yielded a good correlation coefficient (r(2)=0.9968). The underestimated results of LC-MS/MS resulted in a higher adsorption constant of ATZ in soil derived from LC-MS/MS than that of a biosensor. The proposed EWOB system provides a simple, green, and powerful tool to investigate the transport mechanism and fate of pesticide residues.

  6. Assessing lahars from ice-capped volcanoes using ASTER satellite data, the SRTM DTM and two different flow models: case study on Iztaccíhuatl (Central Mexico)

    Science.gov (United States)

    Schneider, D.; Delgado Granados, H.; Huggel, C.; Kääb, A.

    2008-06-01

    Lahars frequently affect the slopes of ice-capped volcanoes. They can be triggered by volcano-ice interactions during eruptions but also by processes such as intense precipitation or by outbursts of glacial water bodies not directly related to eruptive activity. We use remote sensing, GIS and lahar models in combination with ground observations for an initial lahar hazard assessment on Iztaccíhuatl volcano (5230 m a.s.l.), considering also possible future developments of the glaciers on the volcano. Observations of the glacial extent are important for estimations of future hazard scenarios, especially in a rapidly changing tropical glacial environment. In this study, analysis of the glaciers on Iztaccíhuatl shows a dramatic retreat during the last 150 years: the glaciated area in 2007 corresponds to only 4% of the one in 1850 AD and the glaciers are expected to survive no later than the year 2020. Most of the glacial retreat is considered to be related to climate change but in-situ observations suggest also that geo- and hydrothermal heat flow at the summit-crater area can not be ruled out, as emphasized by fumarolic activity documented in a former study. However, development of crater lakes and englacial water reservoirs are supposed to be a more realistic scenario for lahar generation than sudden ice melting by rigorous volcano-ice interaction. Model calculations show that possible outburst floods have to be larger than ~5×105 m3 or to achieve an H/L ratio (Height/runout Length) of 0.2 and lower in order to reach the populated lower flanks. This threshold volume equals 2.4% melted ice of Iztaccíhuatl's total ice volume in 2007, assuming 40% water and 60% volumetric debris content of a potential lahar. The model sensitivity analysis reveals important effects of the generic type of the Digital Terrain Model (DTM) used on the results. As a consequence, the predicted affected areas can vary significantly. For such hazard zonation, we therefore suggest the use of

  7. Assessing lahars from ice-capped volcanoes using ASTER satellite data, the SRTM DTM and two different flow models: case study on Iztaccíhuatl (Central Mexico

    Directory of Open Access Journals (Sweden)

    D. Schneider

    2008-06-01

    Full Text Available Lahars frequently affect the slopes of ice-capped volcanoes. They can be triggered by volcano-ice interactions during eruptions but also by processes such as intense precipitation or by outbursts of glacial water bodies not directly related to eruptive activity. We use remote sensing, GIS and lahar models in combination with ground observations for an initial lahar hazard assessment on Iztaccíhuatl volcano (5230 m a.s.l., considering also possible future developments of the glaciers on the volcano. Observations of the glacial extent are important for estimations of future hazard scenarios, especially in a rapidly changing tropical glacial environment. In this study, analysis of the glaciers on Iztaccíhuatl shows a dramatic retreat during the last 150 years: the glaciated area in 2007 corresponds to only 4% of the one in 1850 AD and the glaciers are expected to survive no later than the year 2020. Most of the glacial retreat is considered to be related to climate change but in-situ observations suggest also that geo- and hydrothermal heat flow at the summit-crater area can not be ruled out, as emphasized by fumarolic activity documented in a former study. However, development of crater lakes and englacial water reservoirs are supposed to be a more realistic scenario for lahar generation than sudden ice melting by rigorous volcano-ice interaction. Model calculations show that possible outburst floods have to be larger than ~5×105 m3 or to achieve an H/L ratio (Height/runout Length of 0.2 and lower in order to reach the populated lower flanks. This threshold volume equals 2.4% melted ice of Iztaccíhuatl's total ice volume in 2007, assuming 40% water and 60% volumetric debris content of a potential lahar. The model sensitivity analysis reveals important effects of the generic type of the Digital Terrain Model (DTM used on the results. As a consequence, the predicted affected areas can vary significantly. For such

  8. Human health impacts for renewable energy scenarios from the EnerGEO Platform of Integrated Assessment (PIA)

    Energy Technology Data Exchange (ETDEWEB)

    Lefevre, Mireille; Gschwind, Benoit; Blanc, Isabelle; Ranchin, Thierry [MINES ParisTech, Sophia Antipolis (France). Observation, Impacts, Energy Center; Wyrwa, Artur; Drebszok, Kamila [AGH Univ. of Science and Technology, Krakow (Poland); Cofala, Janusz; Fuss, Sabine [International Institute for Applied Systems Analysis (IIASA), Laxenburg (Austria)

    2013-07-01

    This article reports impact results from running the EnerGEO Platform of Integrated Assessment (PIA) related to human health for different scenarios in Europe. The scenarios were prepared within the EnerGEO project. The idea of this European project is to determine how low carbon scenarios, and in particular scenarios with a high share of renewable energy, affect concentrations of air pollutants and as a consequence affect human health. PM{sub 2.5} concentrations were estimated with the IIASA Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS) model on a time horizon up to the year 2050 for different scenarios. We analyse here the estimation of the Loss of Life Expectancy due to PM{sub 2.5} concentrations for the Baseline scenario taken as a reference and the Maximum renewable power scenario. (orig.)

  9. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis

    2003-05-01

    The present report summarizes the accomplishments of the project during its second three-month period (from January 2003 through March 2003). The project was initiated with delay in February 2003 due to contractual issues that emerged between the NGA and Foster-Miller, Inc. The two organizations are working diligently to maintain the program's pace so that it is completed in time. The efforts of the project focused during this period in the assessment of the tether technology that is intended to be used as the means of communication between robot and operator. Preliminary results indicate that tether is a viable option under certain pipeline operating conditions but not all. The exact range of operating conditions that are viable for tether use are being determined as the study progresses. Work was also initiated regarding the design of the robotic platform.

  10. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yafei [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Brott, David [Patient Safety, AstraZeneca R and D Wilmington, DE 19850 (United States); Luo, Wenli [Discovery Statistics, AstraZeneca R and D Waltham, MA 02451 (United States); Gangl, Eric [DMPK, AstraZeneca R and D Waltham, MA 02451 (United States); Kamendi, Harriet; Barthlow, Herbert; Lengel, David; Fikes, James; Kinter, Lewis [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Valentin, Jean-Pierre [Global Safety Assessment, AstraZeneca R and D Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Bialecki, Russell, E-mail: russell.bialecki@astrazeneca.com [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States)

    2013-05-01

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development.

  11. Assessment of USDA-NRCS Rangeland Conservation Programs: Recommendation for an Evidence-based Conservation Platform

    Science.gov (United States)

    The Conservation Effects Assessment Project (CEAP) was created in response to a request from the Office of Management and Budget that the U.S. Department of Agriculture - Natural Resource Conservation Service (USDA – NRCS) document the societal benefits anticipated to accrue from a major increase in...

  12. The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps

    Directory of Open Access Journals (Sweden)

    Ryffel Gerhart U

    2011-01-01

    Full Text Available Abstract Background The three distinct types of kidneys, pronephros, mesonephros and metanephros, develop consecutively in vertebrates. The earliest form of embryonic kidney, the pronephros, is derived from intermediate mesoderm and the first expressed genes localized in the pronephros anlage are the transcription factors osr1, osr2, hnf1b, lhx1 and pax8, here referred to as the early nephrogenic transcription factors. However, the pathway inducing nephrogenesis and the network of theses factors are poorly understood. Treatment of the undifferentiated animal pole explant (animal cap of Xenopus with activin A and retinoic acid induces pronephros formation providing a powerful tool to analyze key molecular events in nephrogenesis. Results We have investigated the expression kinetics of the early nephrogenic transcription factors in activin A and retinoic acid treated animal caps and their potential to induce pronephric differentiation. In treated animal caps, expression of osr1, osr2, hnf1b and lhx1 are induced early, whereas pax8 expression occurs later implying an indirect activation. Activin A alone is able to induce osr2 and lhx1 after three hours treatment in animal caps while retinoic acid fails to induce any of these nephrogenic transcription factors. The early expression of the five transcription factors and their interference with pronephros development when overexpressed in embryos suggest that these factors potentially induce nephrogenesis upon expression in animal caps. But no pronephros development is achieved by either overexpression of OSR1, by HNF1B injection with activin A treatment, or the combined application of LHX1 and PAX8, although they influenced the expression of several early nephrogenic transcription factors in some cases. In an additional approach we could show that HNF1B induces several genes important in nephrogenesis and regulates lhx1 expression by an HNF1 binding site in the lhx1 promoter. Conclusions The early

  13. Effects of subchronic exposures to concentrated ambient particles in mice. IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs.

    Science.gov (United States)

    Lippmann, Morton; Gordon, Terry; Chen, Lung Chi

    2005-04-01

    In order to examine the biologic plausibility of adverse chronic cardiopulmonary effects in humans associated with ambient particulate matter (PM) exposure, we exposed groups of normal mice (C57) and knockout mice that develop atherosclerotic plaque (ApoE-/- and ApoE-/- LDLr-/-) for 6 h/day, 5 days/wk for 5 or 6 mo during the spring/summer of 2003 to either filtered air or 10-fold concentrated ambient particles (CAPs) in Tuxedo, NY (average PM2.5 concentration during exposure = 110 microg/m3). Some of the mice had implanted electrocardiographic monitors. We demonstrated that: (1) this complex interdisciplinary study was technically feasible in terms of daily exposure, collection of air quality monitoring data, the collection, analysis, and interpretation of continuous data on cardiac function, and the collection and analyses of tissues of the animals sacrificed at the end of the study; (2) the daily variations in CAPs were significantly associated, in ApoE-/- mice, with daily variations in cardiac functions; (3) there were significant differences between CAPs and sham-exposed ApoE-/- mice in terms of cardiac function after the end of exposure period, as well as small differences in atherosclerotic plaque density, coronary artery disease, and cell density in the substantia nigra in the brain in the ApoE-/- mice; (4) there are suggestive indications of gene expression changes for genes associated with the control of circadian rhythm in the ApoE-/- LDLr-/- double knockout (DK) mice. These various CAPs-related effects on cardiac function and the development of histological evidence of increased risk of clinically significant disease at the end of exposures in animal models of atherosclerosis provide biological plausibility for the premature mortality associated with PM2.5 exposure in human subjects and provide suggestive evidence for neurogenic disease as well.

  14. Positional Quality Assessment of Orthophotos Obtained from Sensors Onboard Multi-Rotor UAV Platforms

    Science.gov (United States)

    Mesas-Carrascosa, Francisco Javier; Rumbao, Inmaculada Clavero; Berrocal, Juan Alberto Barrera; Porras, Alfonso García-Ferrer

    2014-01-01

    In this study we explored the positional quality of orthophotos obtained by an unmanned aerial vehicle (UAV). A multi-rotor UAV was used to obtain images using a vertically mounted digital camera. The flight was processed taking into account the photogrammetry workflow: perform the aerial triangulation, generate a digital surface model, orthorectify individual images and finally obtain a mosaic image or final orthophoto. The UAV orthophotos were assessed with various spatial quality tests used by national mapping agencies (NMAs). Results showed that the orthophotos satisfactorily passed the spatial quality tests and are therefore a useful tool for NMAs in their production flowchart. PMID:25587877

  15. Positional quality assessment of orthophotos obtained from sensors onboard multi-rotor UAV platforms.

    Science.gov (United States)

    Mesas-Carrascosa, Francisco Javier; Rumbao, Inmaculada Clavero; Berrocal, Juan Alberto Barrera; Porras, Alfonso García-Ferrer

    2014-11-26

    In this study we explored the positional quality of orthophotos obtained by an unmanned aerial vehicle (UAV). A multi-rotor UAV was used to obtain images using a vertically mounted digital camera. The flight was processed taking into account the photogrammetry workflow: perform the aerial triangulation, generate a digital surface model, orthorectify individual images and finally obtain a mosaic image or final orthophoto. The UAV orthophotos were assessed with various spatial quality tests used by national mapping agencies (NMAs). Results showed that the orthophotos satisfactorily passed the spatial quality tests and are therefore a useful tool for NMAs in their production flowchart.

  16. Implications for platform re-assessment based on in-service damage resulting from accidental loadings

    Energy Technology Data Exchange (ETDEWEB)

    Sharp, J.V.; Stacey, A. [Health and Safety Executive, London (United Kingdom); Frieze, P.A.; Nichols, N.W.

    1996-12-01

    Current offshore design codes enable the capacity of structural components to be determined, but the equations apply only to the undamaged state. The ability to assess the performance of such components containing damage has only recently been developed and is important in the re-assessment of structures. In particular knowledge of the performance of members which are dented or bowed as a result of accidental damage is important in establishing the capacity of structures in-service, when for example using pushover analyses. Much research has been taken on the capacity of dented and bowed members. This paper reviews this data and establishes a database using screening criteria. This data is then compared with theoretical predictions from recently developed draft ISO equations. These show that dents and bows can significantly reduce the performance of members. A survey of offshore damage resulting in repairs has shown that 30% of this damage is the result of accidental events such as ship impact and dropped objects. Most damage found to members was in the form of dents, bows and cracks, with member severance in a few cases. The implications of this information for reassessment and offshore inspections are considered.

  17. A pilot study evaluating use of a computer-assisted neurorehabilitation platform for upper-extremity stroke assessment

    Directory of Open Access Journals (Sweden)

    Feng Xin

    2009-05-01

    Full Text Available Abstract Background There is a need to develop cost-effective, sensitive stroke assessment instruments. One approach is examining kinematic measures derived from goal-directed tasks, which can potentially be sensitive to the subtle changes in the stroke rehabilitation process. This paper presents the findings from a pilot study that uses a computer-assisted neurorehabilitation platform, interfaced with a conventional force-reflecting joystick, to examine the assessment capability of the system by various types of goal-directed tasks. Methods Both stroke subjects with hemiparesis and able-bodied subjects used the force-reflecting joystick to complete a suite of goal-directed tasks under various task settings. Kinematic metrics, developed for specific types of goal-directed tasks, were used to assess various aspects of upper-extremity motor performance across subjects. Results A number of metrics based on kinematic performance were able to differentiate subjects with different impairment levels, with metrics associated with accuracy, steadiness and speed consistency showing the best capability. Significant differences were also shown on these metrics between various force field settings. Conclusion The results support the potential of using UniTherapy software with a conventional joystick system as an upper-extremity assessment instrument. We demonstrated the ability of using various types of goal-directed tasks to distinguish between subjects with different impairment levels. In addition, we were able to show that different force fields have a significant effect on the performance across subjects with different impairment levels in the trajectory tracking task. These results provide motivation for studies with a larger sample size that can more completely span the impairment space, and can use insights presented here to refine considerations of various task settings so as to generalize and extend our conclusions.

  18. Quality Assessment of Roof Planes Extracted from Height Data for Solar Energy Systems by the EAGLE Platform

    Directory of Open Access Journals (Sweden)

    Simon Schuffert

    2015-12-01

    Full Text Available Due to the increasing scarcity of fossil fuels and the upwards trend in energy costs over time, many countries—especially in Europe—have begun to modify their energy policies aiming to increase that percentage obtained from renewable energies. The EAGLE (FP7 program, European Commission has developed a web-based platform to promote renewable energy systems (RES in the public and private sectors, and to deliver a comprehensive information source for all interested users. In this paper, a comprehensive quality assessment of extracted roof planes suitable for solar energy installations (photovoltaic, solar thermal from height data derived automatically from both LiDAR (Light Detection and Ranging and aerial images will be presented. A shadow analysis is performed regarding the daily path of the sun including the shading effects of nearby objects (chimneys, dormers, vegetation, buildings, topography, etc.. A quality assessment was carried out for both LiDAR and aerial images of the same test sites in UK and Germany concerning building outline accuracy, extraction rate of roof planes and the accuracy of their geometric parameters (inclination and aspect angle, size. The benefit is an optimized system to extract roof planes for RES with a high level of detail, accuracy and flexibility (concerning different commonly available data sources including an estimation of quality of the results which is important for individual house owners as well as for regional applications by governments or solar energy companies to judge their usefulness.

  19. Assessing the Quality, Feasibility, and Efficacy of Electronic Patient Platforms Designed to Support Adolescents and Young Adults With Cancer: A Systematic Review Protocol

    Science.gov (United States)

    McCann, Lisa

    2017-01-01

    Background A range of innovative websites, mobile technologies, eHealth and mHealth platforms have emerged to support adolescents and young adults (AYAs) with cancer. Previous reviews have identified these various applications and solutions, but no review has summarized the quality, feasibility, and efficacy of existing patient platforms (inclusive of websites, mobile technologies, mHealth and eHealth platforms) developed specifically for young people with cancer. Objective This paper describes the design of a protocol to conduct a review of published studies or reports which describe or report on an existing platform designed specifically for AYAs who have had a cancer diagnosis. Methods A search string was developed using a variety of key words and Medical Subject Heading and applied to bibliographic databases. General data (sample characteristics, patient platform development, design and, if applicable, pilot testing outcomes) will be extracted from reports and studies. Drawing on a previously developed coding schematic, the identified patient platforms will be coded for mode of delivery into (1) automated functions, (2) communicative functions, and (3) use of supplementary modes. An adapted version of the Mobile App Rating Scale (MARS) will be used to assess the of quality of each identified patient platform. The methodological quality of included studies will be assessed using the Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields (QualSyst). Both authors will independently screen eligible studies for final inclusion and will both be responsible for data extraction and appraisal. Data will be synthesized narratively to provide an overview of identified patient platforms. Results The review began in October 2016 and is currently in progress. The review paper will be submitted for peer-review and publication in the summer of 2017. Conclusions This review will be unique in its focus on assessing, where possible, the

  20. North Polar Cap

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] This week we will be looking at five examples of laminar wind flow on the north polar cap. On Earth, gravity-driven south polar cap winds are termed 'catabatic' winds. Catabatic winds begin over the smooth expanse of the cap interior due to temperature differences between the atmosphere and the surface. Once begun, the winds sweep outward along the surface of the polar cap toward the sea. As the polar surface slopes down toward sealevel, the wind speeds increase. Catabatic wind speeds in the Antartic can reach several hundreds of miles per hour. In the images of the Martian north polar cap we can see these same type of winds. Notice the streamers of dust moving downslope over the darker trough sides, these streamers show the laminar flow regime coming off the cap. Within the trough we see turbulent clouds of dust, kicked up at the trough base as the winds slow down and enter a chaotic flow regime. The horizontal lines in these images are due to framelet overlap and lighting conditions over the bright polar cap. Image information: VIS instrument. Latitude 86.5, Longitude 64.5 East (295.5 West). 40 meter/pixel resolution. Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time. NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen

  1. [Engine-driven preparation of curved root canals: a platform to assess physical parameters].

    Science.gov (United States)

    Peters, O A; Kappeler, S; Bucher, W; Barbakow, F

    2001-01-01

    The number of engine-driven rotary instruments available on the market is steadily increasing. These instruments enable clinicians to prepare better shaped root canals, however, rotary instruments have a higher risk for fracture than hand instruments. Unfortunately, the stresses placed on engine-driven rotary instruments in curved canals are insufficiently studied. The aim of this study was to develop a device which could measure more accurately the physical parameters influencing rotary instruments in curved canals. For this purpose, a specially designed machine was constructed to measure the torque which develops between the rotary instrument and the motor. Apical forces and penetration depths could also be directly measured in real time. A variety of other measurements was also possible because of other special set-ups integrated into the device. In the current study torque was assessed for GT-Files, size 35 with a .12 and sizes 20 with a .12 to .06 taper. In additions to preparations in simulated canals in plastic blocks, the "ISO 3630-1 specification for fracture moment" and "number of cycles till fatigue fracture" was measured. The findings indicated that when instruments were used for preparations, torques up to 40 Nmm were present. This exceeded the static fracture load, which was less than than 13 Nmm for the size 20 with .12 taper. In contrast, the number of rotations were more than 10 times lower when shaping canals in plastic blocks with a 5 mm radius of curvature than the number of rotations to fracture in the "cyclic fatigue test". This suggests that a GT-instrument could be used in ten canals. The apical force was always greater than 1 N and occasionally, 8 N or more was recorded. Further studies on natural teeth with varying canal geometries are required using the specially developed torsional machine to reduce the incidence of instrument fracture. In this way an efficient clinical potential can be confirmed for engine-driven rotary instruments in

  2. Dendrimer, liposomes, carbon nanotubes and PLGA nanoparticles: one platform assessment of drug delivery potential.

    Science.gov (United States)

    Mody, Nishi; Tekade, Rakesh Kumar; Mehra, Neelesh Kumar; Chopdey, Prashant; Jain, Narendra Kumar

    2014-04-01

    Liposomes (LIP), nanoparticles (NP), dendrimers (DEN), and carbon nanotubes (CNTs), represent eminent classes of drug delivery devices. A study was carried out herewith by employing docetaxel (DTX) as model drug to assess their comparative drug delivery potentials. Under optimized conditions, highest entrapment of DTX was observed in CNT-based formulation (DTX-CNTs, 74.70 ± 4.9%) followed by nanoparticles (DTX-NP, 62.34 ± 1.5%), liposome (49.2 ± 1.51%), and dendrimers (28.26 ± 1.74%). All the formulations were found to be of nanometric size. In vitro release studies were carried out in PBS (pH 7.0 and 4.0), wherein all the formulations showed biphasic release pattern. Cytotoxicity assay in human cervical cancer SiHa cells inferred lowest IC50 value of 1,235.09 ± 41.93 nM with DTX-CNTs, followed by DTX-DEN, DTX-LIP, DTX-NP with IC50 values of 1,571.22 ± 151.27, 1,653.98 ± 72.89, 1,922.75 ± 75.15 nM, respectively. Plain DTX showed higher hemolytic toxicity of 22.48 ± 0.94%, however loading of DTX inside nanocarriers drastically reduced its hemolytic toxicity (DTX-DEN, 17.22 ± 0.48%; DTX-LIP, 4.13 ± 0.19%; DTX-NP, 6.43 ± 0.44%; DTX-CNTs, 14.87 ± 1.69%).

  3. Air Force Genomics, Proteomics, Bioinformatics System, DataCap-Data Collection Module. Phase 1: Development

    Science.gov (United States)

    2004-07-01

    exist as a series of isolated computational silos, providing a depth of data in a narrow field of research. The Acero Genomics Knowledge Platform (GKP...on top of the Acero Platform. The purpose of the DataCap is to provide the individual researcher with the ability to collect experimental data in a...integrated format compatible with the Acero GKP. This technical report covers the architecture, the design and the operation of the DataCap in its

  4. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis

    2003-07-01

    This development program is a joint effort among the Northeast Gas Association (formerly New York Gas Group), Foster-Miller, Inc., and the US Department of Energy (DOE) through the National Energy Technology Laboratory (NETL). The DOE's contribution to this project is $572,525 out of a total of $772,525. The present report summarizes the accomplishments of the project during its third three-month period (from April 2003 through June 2003). The project was initiated with delay in February 2003 due to contractual issues that emerged between NGA and Foster-Miller, Inc. The two organizations are working diligently to maintain the program's pace and expect to complete it in time. The efforts of the project focused during this period in finalizing the assessment of the tether technology, which is intended to be used as the means of communication between robot and operator. Results indicate that the tether is a viable option under certain pipeline operating conditions, but not all. Concerns also exist regarding the abrasion resistance of the tether, this issue being the last studied. Substantial work was also conducted on the design of the robotic platform, which has progressed very well. Finally, work on the MFL sensor, able to negotiate all pipeline obstacles (including plug valves), was initiated by PII following the successful completion of the subcontract negotiations between Foster-Miller and PII. The sensor design is at this point the critical path in the project's timetable.

  5. Assessment of the Effectiveness of Internet-Based Distance Learning through the VClass e-Education Platform

    Directory of Open Access Journals (Sweden)

    Chadchadaporn Pukkaew

    2013-09-01

    Full Text Available This study assesses the effectiveness of internet-based distance learning (IBDL through the VClass live e-education platform. The research examines (1 the effectiveness of IBDL for regular and distance students and (2 the distance students’ experience of VClass in the IBDL course entitled Computer Programming 1. The study employed the common definitions of evaluation to attain useful statistical results. The measurement instruments used were test scores and questionnaires. The sample consisted of 59 first-year undergraduate students, most of whom were studying computer information systems at Rajamangala University of Technology Lanna Chiang Mai in Thailand. The results revealed that distance students engaged in learning behavior only occasionally but that the effectiveness of learning was the same for distance and regular students. Moreover, the provided computer-mediated communications (CMC (e.g., live chat, email, and discussion board were sparingly used, primarily by male distance students. Distance students, regular students, the instructor, and the tutor agreed to use a social networking site, Facebook, rather than the provided CMC during the course. The evaluation results produce useful information that is applicable for developing and improving IBDL practices.

  6. Increased 5. cap alpha. -reductase activity in idiopathic hirsutism

    Energy Technology Data Exchange (ETDEWEB)

    Serafini, P.; Lobo, R.A.

    1985-01-01

    In vitro, genital skin 5..cap alpha..-reductase activity (5..cap alpha..-RA) was measured in ten hirsute women with normal androgen levels (idiopathic hirsutism (IH)) and in ten hirsute women with elevated androgen levels (polycystic ovary syndrome (PCO)) in order to determine the influence of secreted androgens on 5..cap alpha..-RA. In vitro 5..cap alpha..-RA was assessed by incubations of skin with /sup 14/C-testosterone (T) for 2 hours, after which steroids were separated and the radioactivity of dihydrotestosterone (DHT) and 5..cap alpha..-androstane 3..cap alpha..-17..beta..-estradiol (3..cap alpha..-diol) in specific eluates were determined. All androgens were normal in IH with the exception of higher levels of 3..cap alpha..-diol glucuronide which were similar to the levels of PCO. The conversion ratio (CR) of T to DHT in IH and PCO were similar, yet significantly greater than the CR of control subjects. The CR of T to 3..cap alpha..-diol in IH and PCO were similar, yet higher than in control subjects. Serum androgens showed no correlation with 5..cap alpha..-RA, while the CR of T to DHT showed a significant positive correlation with the Ferriman and Gallwey score. The increased 5..cap alpha..-RA in IH appears to be independent of serum androgen levels and is, therefore, an inherent abnormality. The term idiopathic is a misnomer, because hirsutism in these patients may be explained on the basis of increased skin 5..cap alpha..-RA.

  7. Saltstone Clean Cap Formulation

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C

    2005-04-22

    The current operation strategy for using Saltstone Vault 4 to receive 0.2 Ci/gallon salt solution waste involves pouring a clean grout layer over the radioactive grout prior to initiating pour into another cell. This will minimize the radiating surface area and reduce the dose rate at the vault and surrounding area. The Clean Cap will be used to shield about four feet of Saltstone poured into a Z-Area vault cell prior to moving to another cell. The minimum thickness of the Clean Cap layer will be determined by the cesium concentration and resulting dose levels and it is expected to be about one foot thick based on current calculations for 0.1 Ci Saltstone that is produced in the Saltstone process by stabilization of 0.2 Ci salt solution. This report documents experiments performed to identify a formulation for the Clean Cap. Thermal transient calculations, adiabatic temperature rise measurements, pour height, time between pour calculations and shielding calculations were beyond the scope and time limitations of this study. However, data required for shielding calculations (composition and specific gravity) are provided for shielding calculations. The approach used to design a Clean Cap formulation was to produce a slurry from the reference premix (10/45/45 weight percent cement/slag/fly ash) and domestic water that resembled as closely as possible the properties of the Saltstone slurry. In addition, options were investigated that may offer advantages such as less bleed water and less heat generation. The options with less bleed water required addition of dispersants. The options with lower heat contained more fly ash and less slag. A mix containing 10/45/45 weight percent cement/slag/fly ash with a water to premix ratio of 0.60 is recommended for the Clean Cap. Although this mix may generate more than 3 volume percent standing water (bleed water), it has rheological, mixing and flow properties that are similar to previously processed Saltstone. The recommended

  8. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis; Bill Leary

    2004-01-14

    This development program is a joint effort among the Northeast Gas Association (formerly New York Gas Group), Foster-Miller, Inc., and the US Department of Energy (DOE) through the National Energy Technology Laboratory (NETL). The total cost of the project is $772,525, with the National Energy Technology Laboratory of the US Department of Energy contributing $572,525, and the Northeast Gas Association contributing $200,000. The present report summarizes the accomplishments of the project during its fourth three-month period (from July 2003 through September 2003). The efforts of the project focused during this period in completing the assessment of the tether technology, which is intended to be used as the means of communication between robot and operator, in designing the MFL sensor module, in completing the kinematic studies, and in initiating tractor design. In addition, work on the ovality sensor progressed significantly, while work on system integration was initiated focusing at this point in time on module coupling. Results to date indicate that the robotic system under design will be able to meet most of the design specifications initially specified. Earlier concerns regarding the portability of the system are shown to be a non-issue, with new more detailed analysis showing that from a locomotor point of view an inspection of a 16 inch-24 inch pipe size range with a single platform is most likely possible However, the limitations imposed by the sensor are more restrictive, preliminary results indicating an inspection range of 16 inch-20 inch pipe sizes. In addition, tether use will most likely have to be limited to medium and low flow conditions in order to preserve tether integrity.

  9. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OR SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis

    2004-02-01

    This development program is a joint effort among the Northeast Gas Association (formerly New York Gas Group), Foster-Miller, Inc., GE Oil & Gas (PII), and the US Department of Energy (DOE) through the National Energy Technology Laboratory (NETL). The total cost of the project is $772,525, with the National Energy Technology Laboratory of the US Department of Energy contributing $572,525, and the Northeast Gas Association contributing $200,000. The present report summarizes the accomplishments of the project during its fifth three-month period (from October 2003 through December 2003). The efforts of the project focused during this period in completing the assessment of the tether technology, which is intended to be used as the means of communication between robot and operator, in completing the design of the MFL sensor modules, and in completing the kinematic studies and tractor design. In addition, work on the ovality sensor has been completed, while work on system integration is nearly complete. Results to date indicate that the robotic system under design will be able to meet most of the design specifications initially prescribed. The kinematic analysis shows that from a locomotor point of view an inspection of a 16 inch-24 inch pipe size range with a single platform is most likely possible. However, the limitations imposed by the sensor are more restrictive, final preliminary design results showing that in order to cover this pipe range, two different sensor systems will be needed; one for the 16 inch-20 inch pipe size range and one for the 20 inch-24 inch range. Finally, the analysis has shown that tether operation will be limited to flows of less than 30 ft/sec; these results will have to be confirmed experimentally during the next phase of work.

  10. Polar Cap Retreat

    Science.gov (United States)

    2004-01-01

    13 August 2004 This red wide angle Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a view of the retreating seasonal south polar cap in the most recent spring in late 2003. Bright areas are covered with frost, dark areas are those from which the solid carbon dioxide has sublimed away. The center of this image is located near 76.5oS, 28.2oW. The scene is large; it covers an area about 250 km (155 mi) across. The scene is illuminated by sunlight from the upper left.

  11. In-situ subaqueous capping of mercury-contaminated sediments in a fresh-water aquatic system, Part I—Bench-scale microcosm study to assess methylmercury production

    Energy Technology Data Exchange (ETDEWEB)

    Randall, Paul M., E-mail: randall.paul@epa.gov [U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 26 W. Martin Luther King Drive, Cincinnati, OH 45268 (United States); Fimmen, Ryan [Geosyntec Consultants, 150 E. Wilson Bridge Road, Suite 232, Worthington, OH 43085 (United States); Lal, Vivek; Darlington, Ramona [Battelle, 505 King Ave., Columbus, OH 43201 (United States)

    2013-08-15

    Bench-scale microcosm experiments were designed to provide a better understanding of the potential for Hg methylation in sediments from an aquatic environment. Experiments were conducted to examine the function of sulfate concentration, lactate concentration, the presence/absence of an aqueous inorganic Hg spike, and the presence/absence of inoculums of Desulfovibrio desulfuricans, a strain of sulfate-reducing bacteria (SRB) commonly found in the natural sediments of aquatic environments. Incubations were analyzed for both the rate and extent of (methylmercury) MeHg production. Methylation rates were estimated by analyzing MeHg and Hg after 2, 7, 14, 28, and 42 days. The production of metabolic byproducts, including dissolved gases as a proxy for metabolic utilization of carbon substrate, was also monitored. In all treatments amended with lactate, sulfate, Hg, and SRB, MeHg was produced (37 ng/g-sediment dry weight) after only 48 h of incubation and reached a maximum sediment concentration of 127 ng/g-sediment dry weight after the 42 day incubation period. Aqueous phase production of MeHg was observed to be 10 ng/L after 2 day, reaching a maximum observed concentration of 32.8 ng/L after 14 days, and declining to 10.8 ng/L at the end of the incubation period (42 day). The results of this study further demonstrates that, in the presence of an organic carbon substrate, sulfate, and the appropriate consortia of microorganisms, sedimentary Hg will be transformed into MeHg through bacterial metabolism. Further, this study provided the basis for evaluation of an in-situ subaqueous capping strategy that may limit (or potentially enhance) MeHg production. -- Highlights: • Hg methylation by SRB is limited by the depletion of sulfate and carbon. • Hg methylation is sensitive to competition by methanogens for carbon substrate. • In high lactate environment, all lactate was utilized in the microcosms within seven days. • In the absence of adequate metabolic fuel, Me

  12. Impact Response Study on Covering Cap of Aircraft Big-Size Integral Fuel Tank

    Science.gov (United States)

    Wang, Fusheng; Jia, Senqing; Wang, Yi; Yue, Zhufeng

    2016-10-01

    In order to assess various design concepts and choose a kind of covering cap design scheme which can meet the requirements of airworthiness standard and ensure the safety of fuel tank. Using finite element software ANSYS/LS- DYNA, the impact process of covering cap of aircraft fuel tank by projectile were simulated, in which dynamical characteristics of simple single covering cap and gland double-layer covering cap impacted by titanium alloy projectile and rubber projectile were studied, as well as factor effects on simple single covering cap and gland double-layer covering cap under impact region, impact angle and impact energy were also studied. Though the comparison of critical damage velocity and element deleted number of the covering caps, it shows that the external covering cap has a good protection effect on internal covering cap. The regions close to boundary are vulnerable to appear impact damage with titanium alloy projectile while the regions close to center is vulnerable to occur damage with rubber projectile. Equivalent strain in covering cap is very little when impact angle is less than 15°. Element deleted number in covering cap reaches the maximum when impact angle is between 60°and 65°by titanium alloy projectile. While the bigger the impact angle and the more serious damage of the covering cap will be when rubber projectile impact composite covering cap. The energy needed for occurring damage on external covering cap and internal covering cap is less than and higher than that when single covering cap occur damage, respectively. The energy needed for complete breakdown of double-layer covering cap is much higher than that of single covering cap.

  13. A combined approach to assessing the conservation status of Cap des Trois Fourches as a potential MPA: is there a shortage of MPAs in the southern Mediterranean?

    Directory of Open Access Journals (Sweden)

    F. ESPINOSA

    2014-09-01

    Full Text Available The Mediterranean basin is recognized as one of the most diverse regions on the planet, but is being threatened by overexploitation and habitat loss. Furthermore, the Strait of Gibraltar and adjacent Alboran Sea have been identified as representing an important habitat for many threatened or endangered species. In this context, one vehicle for marine conservation is the creation of marine protected sites, although Mediterranean Marine Protected Areas (MPAs are neither large nor representative enough to form an effective network of protection. An inventory of the benthic communities and habitats of conservation interest has been carried out in Cap des Trois Fourches, an ecological and biogeographical site of interest. Univariate and multivariate analyses showed differences for marine communities among habitats and localities, indicating a great diversity in marine assemblages but an absence of a spatial gradient in marine α-diversity. The Trois Fourches area showed a high environmental quality and hosted several endangered species. Habitats of conservation concern, such as marine caves, seagrass meadows and coralligenous assemblages, were detected and studied. The scientific data recorded provide sound support for the establishment of a new MPA in Trois Fourches, taking into account that the findings match the scientific criteria required for declaration as a protected area. The benefits for connectivity at the Mediterranean scale and the local economy are discussed.

  14. A simplified method in comparison with comprehensive interaction incremental dynamic analysis to assess seismic performance of jacket-type offshore platforms

    Science.gov (United States)

    Zolfaghari, M. R.; Ajamy, A.; Asgarian, B.

    2015-12-01

    The primary goal of seismic reassessment procedures in oil platform codes is to determine the reliability of a platform under extreme earthquake loading. Therefore, in this paper, a simplified method is proposed to assess seismic performance of existing jacket-type offshore platforms (JTOP) in regions ranging from near-elastic to global collapse. The simplified method curve exploits well agreement between static pushover (SPO) curve and the entire summarized interaction incremental dynamic analysis (CI-IDA) curve of the platform. Although the CI-IDA method offers better understanding and better modelling of the phenomenon, it is a time-consuming and challenging task. To overcome the challenges, the simplified procedure, a fast and accurate approach, is introduced based on SPO analysis. Then, an existing JTOP in the Persian Gulf is presented to illustrate the procedure, and finally a comparison is made between the simplified method and CI-IDA results. The simplified method is very informative and practical for current engineering purposes. It is able to predict seismic performance elasticity to global dynamic instability with reasonable accuracy and little computational effort.

  15. Recent advances and design considerations in capping systems

    Energy Technology Data Exchange (ETDEWEB)

    DiPippo, G.J.; Monteleone, M.J. [Eckenfelder Inc., Mahwah, NJ (United States)

    1996-12-31

    Capping systems for solid and hazardous waste management facilities and remedial applications have changed significantly over the years. Early designs were virtually monolithic, with little specification of functional properties. The evolution of capping systems has continued and was hastened by the application of geosynthetics and the diligence of those working in the industry in understanding the design considerations for and performance of various capping materials. Capping systems continue to evolve particularly with respect to the application and understanding of the geosynthetic components. Today the design of an effective cap with a total thickness of two feet, or even less as is discussed further below, is possible. Yet much more work remains in various areas such as more precise means of assessing stability, the effects of strain softening, design using seismic considerations, and the like. This paper describes various recent advances in cap design. Three of these advances are covered in some detail; namely, geosynthetic clay layers, subdrainage design using high capacity geonets, and a thin cap section using direct asphalt overlay of geosynthetics for industrial site applications. Several other advances and design considerations are more briefly addressed to illustrate the breadth of the evolution of capping systems.

  16. Short-term sea ice forecasting: An assessment of ice concentration and ice drift forecasts using the U.S. Navy's Arctic Cap Nowcast/Forecast System

    Science.gov (United States)

    Hebert, David A.; Allard, Richard A.; Metzger, E. Joseph; Posey, Pamela G.; Preller, Ruth H.; Wallcraft, Alan J.; Phelps, Michael W.; Smedstad, Ole Martin

    2015-12-01

    In this study the forecast skill of the U.S. Navy operational Arctic sea ice forecast system, the Arctic Cap Nowcast/Forecast System (ACNFS), is presented for the period February 2014 to June 2015. ACNFS is designed to provide short term, 1-7 day forecasts of Arctic sea ice and ocean conditions. Many quantities are forecast by ACNFS; the most commonly used include ice concentration, ice thickness, ice velocity, sea surface temperature, sea surface salinity, and sea surface velocities. Ice concentration forecast skill is compared to a persistent ice state and historical sea ice climatology. Skill scores are focused on areas where ice concentration changes by ±5% or more, and are therefore limited to primarily the marginal ice zone. We demonstrate that ACNFS forecasts are skilful compared to assuming a persistent ice state, especially beyond 24 h. ACNFS is also shown to be particularly skilful compared to a climatologic state for forecasts up to 102 h. Modeled ice drift velocity is compared to observed buoy data from the International Arctic Buoy Programme. A seasonal bias is shown where ACNFS is slower than IABP velocity in the summer months and faster in the winter months. In February 2015, ACNFS began to assimilate a blended ice concentration derived from Advanced Microwave Scanning Radiometer 2 (AMSR2) and the Interactive Multisensor Snow and Ice Mapping System (IMS). Preliminary results show that assimilating AMSR2 blended with IMS improves the short-term forecast skill and ice edge location compared to the independently derived National Ice Center Ice Edge product.

  17. Development of Gasless Pyrotechnic Cap

    Science.gov (United States)

    1980-05-01

    beam cathode ray oscillo- scope. The caps were ignited by removing the safety pin . This also triggered the oscilloscope. The change in pressure inside...sensitivity. STRIKER SAFETY PIN PERCUSSION CAP FIXED VOLUME / ;PRESSURE TRANSDUCER TO C.R.O. FIG. 8 - Device used to determine pressure time

  18. A Prospective Clinical and Radiographic Assessment of Platform-Switched Laser-Microchannel Implants Placed in Limited Interimplant Spaces.

    Science.gov (United States)

    Nevins, Myron; Leziy, Sonia; Kerr, Eric; Janke, Ulrich; Rasperini, Giulio; Hanratty, James; Pasquinelli, Kirk; Testori, Tiziano; Shapoff, Cary A; Kim, David M

    This multicenter clinical trial of platform-switched laser-microchannel implants supports findings from a previous preclinical trial. Previous information indicated that an interimplant distance narrower than 3 mm would result in decrease in the crestal bone level, but the results of this investigation suggest that a more optimistic clinical result can be anticipated for implants and abutments with a laser-microchannel surface.

  19. Palmer Quest: A Feasible Nuclear Fission "Vision Mission" to the Mars Polar Caps

    Science.gov (United States)

    Carsey, F. D.; Beegle, L. W.; Nakagawa, R.; Elliott, J. O.; Matthews, J. B.; Coleman, M. L.; Hecht, M. H.; Ivaniov, A. B.; Head, J. W.; Milkovich, S.

    2005-01-01

    We are engaged in a NASA Vision Mission study, called Palmer Quest after the American Antarctic explorer Nathaniel Palmer, to assess the presence of life and evaluate the habitability of the basal domain of the Mars polar caps. We address this goal through four objectives: 1. Determine the presence of amino acids, nutrients, and geochemical heterogeneity in the ice sheet. 2. Quantify and characterize the provenance of the amino acids in Mars ice. 3. Assess the stratification of outcropped units for indications of habitable zones. 4. Determine the accumulation of ice, mineralogic material, and amino acids in Mars ice caps over the present epoch. Because of the defined scientific goal for the vision mission, the Palmer Quest focus is astrobiological; however, the results of the study make us optimistic that aggressive multi-platform in-situ missions that address a wide range of objectives, such as climate change, can be supported by variations of the approach used on this mission. Mission Overview: The Palmer Quest baseline

  20. A Multi-Peer Assessment Platform for Programming Language Learning: Considering Group Non-Consensus and Personal Radicalness

    Science.gov (United States)

    Wang, Yanqing; Liang, Yaowen; Liu, Luning; Liu, Ying

    2016-01-01

    Multi-peer assessment has often been used by teachers to reduce personal bias and make the assessment more reliable. This study reviews the design and development of multi-peer assessment systems that detect and solve two common issues in such systems: non-consensus among group members and personal radicalness in some assessments. A multi-peer…

  1. Temperature Distribution within a Cold Cap during Nuclear Waste Vitrification.

    Science.gov (United States)

    Dixon, Derek R; Schweiger, Michael J; Riley, Brian J; Pokorny, Richard; Hrma, Pavel

    2015-07-21

    The kinetics of the feed-to-glass conversion affects the waste vitrification rate in an electric glass melter. The primary area of interest in this conversion process is the cold cap, a layer of reacting feed on top of the molten glass. The work presented here provides an experimental determination of the temperature distribution within the cold cap. Because direct measurement of the temperature field within the cold cap is impracticable, an indirect method was developed in which the textural features in a laboratory-made cold cap with a simulated high-level waste feed were mapped as a function of position using optical microscopy, scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. The temperature distribution within the cold cap was established by correlating microstructures of cold-cap regions with heat-treated feed samples of nearly identical structures at known temperatures. This temperature profile was compared with a mathematically simulated profile generated by a cold-cap model that has been developed to assess the rate of glass production in a melter.

  2. A Multichannel Bioluminescence Determination Platform for Bioassays.

    Science.gov (United States)

    Kim, Sung-Bae; Naganawa, Ryuichi

    2016-01-01

    The present protocol introduces a multichannel bioluminescence determination platform allowing a high sample throughput determination of weak bioluminescence with reduced standard deviations. The platform is designed to carry a multichannel conveyer, an optical filter, and a mirror cap. The platform enables us to near-simultaneously determine ligands in multiple samples without the replacement of the sample tubes. Furthermore, the optical filters beneath the multichannel conveyer are designed to easily discriminate colors during assays. This optical system provides excellent time- and labor-efficiency to users during bioassays.

  3. Platform contents

    OpenAIRE

    Renault, Régis

    2014-01-01

    A monopoly platform hosts advertisers who compete on a market for horizontally differentiated products. These products may be either mass market products that appeal broadly to the entire consumer population or niche products that are tailored to the tastes of some particular group. Consumers search sequentially through ads incurring a surfing cost of moving to the next ad. They may click on an ad at some cost, which provides all relevant information and the opportunity to buy. The platform c...

  4. [Lens platform].

    Science.gov (United States)

    Łukaszewska-Smyk, Agnieszka; Kałuzny, Józef

    2010-01-01

    The lens platform defines lens structure and lens material. Evolution of lens comprises change in their shape, angulation of haptens and transition of three-piece lens into one-piece lens. The lens fall into two categories: rigid (PMMA) and soft (siliconic, acrylic, colameric). The main lens maaterials are polymers (hydrophilic and hydrophobic). The lens platform has an effect on biocompatibility, bioadhesion, stability of lens in capsule, degree of PCO evolution and sensitiveness to laser damages.

  5. ATLAS - End-Cap calorimeter

    CERN Multimedia

    2006-01-01

    The End-cap calorimeter was moved with the help of the rails and this calorimeter will measure the energy of particles close to the beam axis when protons collide. Cooling is important for maximum detector efficiency.

  6. Interfacial and Wall Transport Models for SPACE-CAP Code

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Soon Joon; Choo, Yeon Joon; Han, Tae Young; Hwang, Su Hyun; Lee, Byung Chul [FNC Tech., Seoul (Korea, Republic of); Choi, Hoon; Ha, Sang Jun [Korea Electric Power Research Institute, Daejeon (Korea, Republic of)

    2009-10-15

    The development project for the domestic design code was launched to be used for the safety and performance analysis of pressurized light water reactors. And CAP (Containment Analysis Package) code has been also developed for the containment safety and performance analysis side by side with SPACE. The CAP code treats three fields (gas, continuous liquid, and dispersed drop) for the assessment of containment specific phenomena, and is featured by its multidimensional assessment capabilities. Thermal hydraulics solver was already developed and now under testing of its stability and soundness. As a next step, interfacial and wall transport models was setup. In order to develop the best model and correlation package for the CAP code, various models currently used in major containment analysis codes, which are GOTHIC, CONTAIN2.0, and CONTEMPT-LT, have been reviewed. The origins of the selected models used in these codes have also been examined to find out if the models have not conflict with a proprietary right. In addition, a literature survey of the recent studies has been performed in order to incorporate the better models for the CAP code. The models and correlations of SPACE were also reviewed. CAP models and correlations are composed of interfacial heat/mass, and momentum transport models, and wall heat/mass, and momentum transport models. This paper discusses on those transport models in the CAP code.

  7. Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins.

    Science.gov (United States)

    Yu, G; Swiston, J; Young, D

    1994-06-01

    We previously reported the identification of human CAP, a protein that is related to the Saccharomyces cerevisiae and Schizosaccharomyces pombe adenylyl cyclase-associated CAP proteins. The two yeast CAP proteins have similar functions: the N-terminal domains are required for the normal function of adenylyl cyclase, while loss of the C-terminal domains result in morphological and nutritional defects that are unrelated to the cAMP pathways. We have amplified and cloned cDNAs from a human glioblastoma library that encode a second CAP-related protein, CAP2. The human CAP and CAP2 proteins are 64% identical. Expression of either human CAP or CAP2 in S. cerevisiae cap- strains suppresses phenotypes associated with deletion of the C-terminal domain of CAP, but does not restore hyper-activation of adenylyl cyclase by RAS2val19. Similarly, expression of either human CAP or CAP2 in S. pombe cap- strains suppresses the morphological and temperature-sensitive phenotypes associated with deletion of the C-terminal domain of CAP in this yeast. In addition, expression of human CAP, but not CAP2, suppresses the propensity to sporulate due to deletion of the N-terminal domain of CAP in S. pombe. This latter observation suggests that human CAP restores normal adenylyl cyclase activity in S. pombe cap- cells. Thus, functional properties of both N-terminal and C-terminal domains are conserved between the human and S. pombe CAP proteins.

  8. Cr isotope stratigraphy of Ediacaran cap dolostones, Doushantuo Formation, South China

    Science.gov (United States)

    Rodler, Alexandra; Hohl, Simon V.; Guo, Qingjun; Frei, Robert

    2016-04-01

    The Yangtze Platform in South China is considered a key site for studying Neoproterozoic ocean oxygenation. The chromium isotope composition (δ53Cr) of marine carbonates has shown to be a sensitive tracer of changing (paleo)redox conditions and was previously linked to photosynthetic activity (1). We applied this emerging proxy to cap dolostones of a deep water and a shallow marine carbonate section pertaining to the Doushantuo Formation that have previously been used to constrain the redox evolution of Ediacaran seawater (2,3). Postglacial detrital contamination and diagenetic alteration appear to have influenced the δ53Cr values of Doushantuo cap dolostones as evidenced by systematic changes in δ53Cr and Cr concentrations coupled with several geochemical tracers. We use Al concentrations as indicator of detrital contamination and to calculate the authigenic Cr isotope composition. Further, we hypothesis that post-depositional remobilization of Cr might have resulted in the loss of heavy Cr isotopes and the retention of light Cr isotopes during precipitation of secondary carbonates. This scenario is supported by a decrease in δ53Cr values that is correlated with a loss of Sr and increasingly light δ18Ocarb signals, which would indicate meteoric fluid/rock interaction and diagenetic alteration by continental basin fluids. However, some cap dolostones may still show pristine Ediacaran seawater signals with positively fractionated δ53Cr (relative to bulk silicate Earth; 4), 87Sr/86Sr close to Ediacaran seawater values and a pronounced negative Ce anomaly. These tracers reveal light pulses of enhanced postglacial oxidative weathering during cap dolostone deposition. The Cr isotope composition of Ediacaran cap dolostones pertaining to the Doushantuo Formation trace changes in past redox conditions, where fine-scale δ53Cr fluctuations are perhaps a result of detrital contamination and diagenetic alteration balanced against a signal of oxidative weathering

  9. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden ...... not have to be very intelligent. This is gradually taken over by applications on smart phones. The ITS Platform with 425 test drivers is now completely developed and can be used for technological testing of e.g. payment systems.......Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden...

  10. DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

    Energy Technology Data Exchange (ETDEWEB)

    George C. Vradis; William Leary

    2004-03-01

    The National Energy Technology Laboratory of the US Department of Energy (under Award DE-FC26-02NT41645) and the NYSEARCH Committee of the Northeast Gas Association (previous the New York Gas Group), have sponsored research to develop a robotic pipeline inspection system capable of navigation through the typical physical and operational obstacles that make transmission and distribution pipelines unpiggable. The research contractors, Foster-Miller and GE Oil & Gas (PII North America) have performed an engineering study and developed a conceptual design that meets all the requirements for navigating and inspecting unpiggable transmission pipelines. Based on Foster-Miller's previous efforts developing the Pipe Mouse robot, the RoboScan inspection robot (Figure ES-1) meets the navigational and physical challenges of unpiggable pipelines through an innovative modular platform design, segmented MFL inspection modules and improvements to the inter-module coupling design.

  11. Platform computing

    CERN Multimedia

    2002-01-01

    "Platform Computing releases first grid-enabled workload management solution for IBM eServer Intel and UNIX high performance computing clusters. This Out-of-the-box solution maximizes the performance and capability of applications on IBM HPC clusters" (1/2 page) .

  12. Payment Platform

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Damsgaard, Jan

    2012-01-01

    Payment transactions through the use of physical coins, bank notes or credit cards have for centuries been the standard formats of exchanging money. Recently online and mobile digital payment platforms has entered the stage as contenders to this position and possibly could penetrate societies tho...

  13. Assessment of the Ionospheric and Tropospheric Effects in Location Errors of Data Collection Platforms in Equatorial Region during High and Low Solar Activity Periods

    Directory of Open Access Journals (Sweden)

    Áurea Aparecida da Silva

    2012-01-01

    Full Text Available The geographical locations of data collection platforms (DCP in the Brazilian Environmental Data Collection System are obtained by processing Doppler shift measurements between satellites and DCP. When the signals travel from a DCP to a satellite crossing the terrestrial atmosphere, they are affected by the atmosphere layers, which generate a delay in the signal propagation, and cause errors in its final location coordinates computation. The signal propagation delay due to the atmospheric effects consists, essentially, of the ionospheric and tropospheric effects. This work provides an assessment of ionospheric effects using IRI and IONEX models and tropospheric delay compensation using climatic data provided by National Climatic Data Center. Two selected DCPs were used in this study in conjunction with SCD-2 satellite during high and low solar activity periods. Results show that the ionospheric effects on transmission delays are significant (about hundreds of meters in equatorial region and should be considered to reduce DCP location errors, mainly in high solar activity periods, while in those due to tropospheric effects the zenith errors are about threemeters. Therefore it is shown that the platform location errors can be reduced when the ionospheric and tropospheric effects are properly considered.

  14. A comprehensive approach to assess Arabidopsis survival phenotype in water-limited condition using a non-invasive high-throughput phenomics platform

    Directory of Open Access Journals (Sweden)

    Emilio eVello

    2015-12-01

    Full Text Available With the rapid rise in global population and the challenges caused by climate changes, the maximization of plant productivity and the development of sustainable agriculture strategies are vital for food security. One of the resources more affected in this new environment will be the limitation of water.In this study, we describe the use of non-invasive technologies exploiting sensors for visible, fluorescent and near-infrared lights to accurately screen survival phenotypes in Arabidopsis thaliana exposed to water-limited conditions. We implemented two drought protocols and a robust analysis methodology that enabled us to clearly assess the wilting or dryness status of the plants at different time points using a phenomics platform. In conclusion, our approach has shown to be very accurate and suitable for experiments where hundred of samples have to be screened making a manual evaluation unthinkable. This approach can be used not only in functional genomics studies but also in agricultural applications.

  15. Pilot study: Assessing repeatability of the EcoWalk platform resistive pressure sensors to measure plantar pressure during barefoot standing

    Science.gov (United States)

    Zequera, Martha; Perdomo, Oscar; Wilches, Carlos; Vizcaya, Pedro

    2013-06-01

    Plantar pressure provides useful information to assess the feet's condition. These systems have emerged as popular tools in clinical environment. These systems present errors and no compensation information is presented by the manufacturer, leading to uncertainty in the measurements. Ten healthy subjects, 5 females and 5 males, were recruited. Lateral load distribution, antero-posterior load distribution, average pressure, contact area, and force were recorded. The aims of this study were to assess repeatability of the EcoWalk system and identify the range of pressure values observed in the normal foot. The coefficient of repeatability was less than 4% for all parameters considered.

  16. Nano-CeO2 decorated graphene based chitosan nanocomposites as enzymatic biosensing platform: fabrication and cellular biocompatibility assessment.

    Science.gov (United States)

    De, Sriparna; Mohanty, Smita; Nayak, Sanjay Kumar

    2015-09-01

    The present study summarizes the designing of a green transducer phase based on nano-cerium oxide (CeO2) decorated reduced graphene oxide (RGO) reinforced chitosan nanocomposites as an effective enzyme immobilizer and bio-sensing matrix for glucose analyte. Also, it scrutinizes the biocompatibility and cell viability of the synthesized nanohybrid with human fibroblastic macrophage cell line. CeO2 nanoparticles (NPs) were successfully grown on graphene nanosheet in the presence of cationic surfactant followed by facile hydrothermal treatment. The eventual growth of synthesized CeO2 nanocrystals on the graphene layer was confirmed from X-ray diffraction (XRD), transmission electron microscopy (TEM) and Raman analysis. The biocompatibility of the synthesized nanohybrid was also evident from the MTT assay. Glucose oxidase (GOx) was employed on the green polymer nanocomposites modified FTO electrode to fabricate an enzymatic bioelectrode. The electroanalytical response of the GOx/nano-CeO2/RGO/CS/FTO bioelectrode towards electrooxidation of glucose analyte was investigated by electrochemical impedance (EIS) and cyclic voltammetry (CV) study. The resulting biosensor exhibited a good electrochemical response to glucose within the linear detection range of 0.05-6.5 mM with a low detection limit of 2 μM and a sensitivity of 7.198 μA mM(-1) cm(-2). The bioelectrode also showed good shelf life (~10 weeks) and negligible interfering ability under controlled environment. The obtained results indicate that nano-CeO2/RGO nanohybrid based chitosan nanocomposites achieve a biocompatible biosensing platform for effective enzyme immobilization due to the excellent synergistic effects between the CeO2 nanoparticles and graphene sheet.

  17. Platform Constellations

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2016-01-01

    messaging apps KakaoTalk and LINE, we are able to gain valuable insights about the nature of these new constructions and to capture and synthesize their main characteristics in a framework. Our results show that platform constellations possess unique innovative capabilities, which can improve users......’ acquisition and users’ engagement rates as well as unlock new sources of value creation and diversify revenue streams....

  18. Field assessment of reproduction-related traits of chironomids using a newly developed emergence platform (E-Board).

    Science.gov (United States)

    Ferrari, Benoît J D; Faburé, Juliette

    2017-03-01

    Further progress in the development of reliable biomonitoring strategies requires to better link effects in aquatic ecological systems to ambient concentrations of chemical contaminants. Among existing tools, in situ bioassays using caging method represent an interesting way to achieve this challenge. However, elaboration of adapted exposure chambers and suitable operating procedures is still required, particularly to assess ecological relevant traits such as those related to the reproduction. In such context, we developed a new device (Emergence board - E-Board) which allows assessing in rivers the development of the Chironomus riparius species from the early fourth instar larvae to the adult stage. The system acts as a suspended matter trap floating in the subsurface of the water equipped of an emergence trap for catching adults. The system was tested in actual field conditions. Its easy handling allowed obtaining data which demonstrated its applicability for assessing the development of the chironomids. Moreover, by adapting energy-based models (DEB) specifically developed in the laboratory for the species C. riparius, we were able to predict the growth pattern and the emergence of chironomids in real environmental conditions. The E-Board represents thus a promising new in situ tool in perspective of evaluation of the quality of the ecosystems.

  19. From Blogs to Bottle Caps

    Science.gov (United States)

    Edinger, Ted

    2012-01-01

    There is a wonderful community of art educators connecting a once-isolated profession through blogging. Art educators around the world are sharing ideas and communicating with their peers through this amazing resource. In this article, the author describes the bottle cap mural at Tulip Grove Elementary School which was inspired by this exchange of…

  20. Synsedimentary deformation and the paleoseismic record in Marinoan cap carbonate of the southern Amazon Craton, Brazil

    Science.gov (United States)

    Soares, Joelson Lima; Nogueira, Afonso César Rodrigues; Domingos, Fábio; Riccomini, Claudio

    2013-12-01

    Event Layers in Neoproterozoic cap carbonates of Brazil's southwestern Amazon Craton record post-Marinoan synsedimentary seismicity. The 35 m-thick cap carbonates overlie glaciogenic sediments related to the Marinoan glaciation (635 Ma) and are comprised of two units: the lower cap consists of dolomite (˜15 m thick) and the upper cap is limestone (˜25 m thick). The cap dolomite includes pinkish crystalline dolostone with even parallel lamination, stratiform stromatolites, eventual tube structures and megaripple bedded peloidal dolostone interpreted as shallow (euphotic) platform deposits. The cap limestone onlaps the cap dolomite and consists of red marl, gray to black bituminous lime mudstone, bituminous shale with abundant calcite crystal fans (pseudomorphs after aragonite) and even parallel lamination interpreted as moderately deep to deep platform deposits. Five successive events of synsedimentary deformation were recognized in the cap carbonates exposed at Mirassol d'Oeste and Tangará da Serra, in Central Brazil: Event 1 - large to small-scale load cast structures in the contact between dolostones and glaciogenic sediments; Event 2 - stromatolitic lamination truncated by tube structures; Event 3 - vertical to subvertical fractures and faults, and large-scale synclines and anticlines with chevron folds; Event 4 - conglomerate and breccia filling neptunian dykes limited by undeformed beds; and Event 5 - slump and sliding deposits found only in the upper part of the cap limestone. Event 1 was produced by hydroplastic dynamics likely induced by isostatic rebound during ice cap melting in the final stages of the Marinoan glaciation. Events 2 and 5 are autocyclic in nature, and related to depositional processes. Event 2 is linked to fluid and methane escape from organic degradation of microbial mats and domes that formed tubestones; Event 5 is associated to collapse and sliding/slumping in the platform and slope. The reliable orientations of synsedimentary faults

  1. Assessment of Registration Information on Methodological Design of Acupuncture RCTs: A Review of 453 Registration Records Retrieved from WHO International Clinical Trials Registry Platform.

    Science.gov (United States)

    Gu, Jing; Wang, Qi; Wang, Xiaogang; Li, Hailong; Gu, Mei; Ming, Haixia; Dong, Xiaoli; Yang, Kehu; Wu, Hongyan

    2014-01-01

    Background. This review provides the first methodological information assessment of protocol of acupuncture RCTs registered in WHO International Clinical Trials Registry Platform (ICTRP). Methods. All records of acupuncture RCTs registered in the ICTRP have been collected. The methodological design assessment involved whether the randomization methods, allocation concealment, and blinding were adequate or not based on the information of registration records (protocols of acupuncture RCTs). Results. A total of 453 records, found in 11 registries, were examined. Methodological details were insufficient in registration records; there were 76.4%, 89.0%, and 21.4% records that did not provide information on randomization methods, allocation concealment, and blinding respectively. The proportions of adequate randomization methods, allocation concealment, and blinding were only 107 (23.6%), 48 (10.6%), and 210 (46.4%), respectively. The methodological design improved year by year, especially after 2007. Additionally, methodology of RCTs with ethics approval was clearly superior to those without ethics approval and different among registries. Conclusions. The overall methodological design based on registration records of acupuncture RCTs is not very well but improved year by year. The insufficient information on randomization methods, allocation concealment, and blinding maybe due to the relevant description is not taken seriously in acupuncture RCTs' registration.

  2. Federal mandatory spending caps vital for health care reform.

    Science.gov (United States)

    Domenici, P V

    1992-01-01

    Rising health spending creates an increasing burden on families, businesses, and government. Federal health spending--chiefly on Medicare and Medicaid--is a major contributor to a budget deficit that threatens to exceed $400 billion. In order to control that deficit, the President and the Congress must cap mandatory spending, excluding Social Security. In turn, policymakers should adopt health reforms to fit spending within the cap including enrolling more consumers in managed care plans, resolving medical liability disputes in arbitration instead of courts, and increasing assessment of research into cost-effective new technology.

  3. Exploring probabilistic tools for the development of a platform for Quantitative Risk Assessment (QRA) of hydro-meteorological hazards in Europe

    Science.gov (United States)

    Zumpano, V.; Hussin, H. Y.; Breinl, K.

    2012-04-01

    Mass-movements and floods are hydro-meteorological hazards that can have catastrophic effects on communities living in mountainous areas prone to these disastrous events. Environmental, climate and socio-economic changes are expected to affect the tempo-spatial patterns of hydro-meteorological hazards and associated risks in Europe. These changes and their effects on the occurrence of future hazards need to be analyzed and modeled using probabilistic hazard and risk assessment methods in order to assist stakeholders in disaster management strategies and policy making. Quantitative Risk Assessment (QRA) using probabilistic methods can further calculate damage and losses to multi-hazards and determine the uncertainties related to all the probabilistic components of the hazard and the vulnerability of the elements at risk. Therefore, in order to develop an effective platform that can quantitatively calculate the risk of mass-movements and floods in several European test sites, an extensive inventory and analysis has been carried out of the available tools and software related to the probabilistic risk assessment of single and multi-hazards. The tools have been reviewed based on whether they are open source and freely available, their required input data, the availability and type of hazard and vulnerability modules, transparency of methods used, their validation and calibration techniques, the inclusion of uncertainties and their state of the art. The analysis also specially focused on the applicability of the tools to European study areas. The findings showed that assumptions and simplifications are made when assessing and quantifying the hazards. The interaction between multiple hazards, like cascading effects are not assessed in most tools and some consider the hazard and vulnerability as qualitative components, rather than quantitative ones. This analysis of hazard and risk assessment tools and software will give future developers and experts a better overview of

  4. The Development of a Mobile Health Platform and Naturalistic Game Applications for Health Assessment, Intervention, and Evaluation

    Science.gov (United States)

    2015-12-01

    GUI   Mockup  (SketchFlow)  for   Sys  Admin  WS,  Professional  WS,  Testing  app   160   DONE   2.2   Create  NCA  game  design   30   DONE   2.3...Select   cognitive   assessment   methods,   design   NCA  tests   100   DONE   3.2   Development  of  NCA   software  modules,  testing   250   DONE   4... software ;;   PARTICIPANTS  &  OTHER  COLLABORATING  ORGANIZATIONS   What  individuals  have  worked  on  the  project?   Name:   Carmen  Russoniello

  5. Highly stable aluminum-based metal-organic frameworks as biosensing platforms for assessment of food safety.

    Science.gov (United States)

    Liu, Chun-Sen; Sun, Chun-Xiao; Tian, Jia-Yue; Wang, Zhuo-Wei; Ji, Hong-Fei; Song, Ying-Pan; Zhang, Shuai; Zhang, Zhi-Hong; He, Ling-Hao; Du, Miao

    2017-05-15

    Two unique immunosensors made of aluminum-based metal-organic frameworks (MOFs), namely, 515- and 516-MOFs, with 4,4',4''-nitrilotribenzoic acid (H3NTB) were successfully obtained to efficiently assess food safety. The as-prepared 515- and 516-MOFs exhibited superior thermal and physicochemical stability, high electrochemical activity, and good biocompatibility. Among these immunosensors, 516-MOF showed a preferable biosensing ability toward analytes determined by electrochemical techniques. The developed 516-MOF-based electrochemical biosensor not only demonstrated high sensitivity with low detection limits of 0.70 and 0.40pgmL(-1) toward vomitoxin and salbutamol, respectively, but also showed good selectivity in the presence of other interferences. Therefore, with the advantages of high sensitivity, good selectivity, and simple operation, this new strategy is believed to exhibit great potential for simple and convenient detection of poisonous and harmful residues in food.

  6. ATLAS End Cap toroid in upstanding position

    CERN Multimedia

    2005-01-01

    End Cap toroid The ATLAS End Cap toroid weights 240-ton and is 12-m diameter high. The parts of this vacuum vessel had to be integrated and tested so that End Cap Toroid has no leaks. After that it could be cooled down to 80 K.

  7. Analyses of hydraulic performance of velocity caps

    DEFF Research Database (Denmark)

    Christensen, Erik Damgaard; Degn Eskesen, Mark Chr.; Buhrkall, Jeppe;

    2014-01-01

    The hydraulic performance of a velocity cap has been investigated. Velocity caps are often used in connection with offshore intakes. CFD (computational fluid dynamics) examined the flow through the cap openings and further down into the intake pipes. This was combined with dimension analyses...

  8. Motion of polar cap arcs

    Science.gov (United States)

    Hosokawa, K.; Moen, J. I.; Shiokawa, K.; Otsuka, Y.

    2011-01-01

    A statistics of motion of polar cap arcs is conducted by using 5 years of optical data from an all-sky imager at Resolute Bay, Canada (74.73°N, 265.07°E). We identified 743 arcs by using an automated arc detection algorithm and statistically examined their moving velocities as estimated by the method of Hosokawa et al. (2006). The number of the arcs studied is about 5 times larger than that in the previous statistics of polar cap arcs by Valladares et al. (1994); thus, we could expect to obtain more statistically significant results. Polar cap arcs are found to fall into two distinct categories: the By-dependent and By-independent arcs. The motion of the former arcs follows the rule reported by Valladares et al. (1994), who showed that stable polar cap arcs move in the direction of the interplanetary magnetic field (IMF) By. About two thirds of the arcs during northward IMF conditions belong to this category. The latter arcs always move poleward irrespective of the sign of the IMF By, which possibly correspond to the poleward moving arcs in the morning side reported by Shiokawa et al. (1997). At least one third of the arcs belong to this category. The By-dependent arcs tend to move faster when the magnitude of the IMF By is larger, suggesting that the transport of open flux by lobe reconnection from one polar cap compartment to the other controls their motion. In contrast, the speed of the By-independent arcs does not correlate with the magnitude of the By. The motions of both the By-dependent and By-independent arcs are most probably caused by the magnetospheric convection. Convection in the region of By-dependent arcs is affected by the IMF By, which indicates that their sources may be on open field lines or in the closed magnetosphere adjacent to the open-closed boundary, whereas By-independent arcs seem to be well on closed field lines. Hence, the magnetospheric source of the two types of arc may be different. This implies that the mechanisms causing the

  9. Economic evaluation of closure cap barrier materials study

    Energy Technology Data Exchange (ETDEWEB)

    Serrato, M.G.; Bhutani, J.S.; Mead, S.M.

    1993-09-01

    Volume II of the Economic Evaluation of the Closure Cap Barrier Materials, Revision I contains detailed cost estimates for closure cap barrier materials. The cost estimates incorporate the life cycle costs for a generic hazardous waste seepage basin closure cap under the RCRA Post Closure Period of thirty years. The economic evaluation assessed six barrier material categories. Each of these categories consists of several composite cover system configurations, which were used to develop individual cost estimates. The information contained in this report is not intended to be used as a cost estimating manual. This information provides the decision makers with the ability to screen barrier materials, cover system configurations, and identify cost-effective materials for further consideration.

  10. Assessing the impact of common forensic presumptive tests on the ability to obtain results using a novel rapid DNA platform.

    Science.gov (United States)

    Donachie, Gillian E; Dawnay, Nick; Ahmed, Romana; Naif, Sarah; Duxbury, Nicola J; Tribble, Nicholas D

    2015-07-01

    The rise of DNA evidence to the forefront of forensic science has led to high sample numbers being submitted for profiling by investigators to casework laboratories: bottleneck effects are often seen resulting in slow turnaround times and sample backlog. The ParaDNA(®) Screening and Intelligence Tests have been designed to guide investigators on the viability of potential sources of DNA allowing them to determine which samples should be sent for full DNA analysis. Both tests are designed to augment the arsenal of available forensic tests for end users and be used concurrently to those commonly available. Therefore, assessing the impact that common forensic tests have on such novel technology is important to measure. The systems were tested against various potential inhibitors to which samples may be exposed as part of the investigative process. Presumptive test agents for biological materials (blood, semen and saliva) and those used as fingerprint enhancement agents were both used. The Screening Test showed a drop in performance following application of aluminium powder and cyanoacrylate (CNA) on fingerprints samples; however this drop in performance was not replicated with high template DNA. No significant effect was observed for any agent using the Intelligence Test. Therefore, both tests stand up well to the chemical agents applied and can be used by investigators with confidence that system performance will be maintained.

  11. Platforms for Building and Deploying Applications for Cloud Computing

    CERN Document Server

    Buyya, Rajkumar

    2011-01-01

    Cloud computing is rapidly emerging as a new paradigm for delivering IT services as utlity-oriented services on subscription-basis. The rapid development of applications and their deployment in Cloud computing environments in efficient manner is a complex task. In this article, we give a brief introduction to Cloud computing technology and Platform as a Service, we examine the offerings in this category, and provide the basis for helping readers to understand basic application platform opportunities in Cloud by technologies such as Microsoft Azure, Sales Force, Google App, and Aneka for Cloud computing. We demonstrate that Manjrasoft Aneka is a Cloud Application Platform (CAP) leveraging these concepts and allowing an easy development of Cloud ready applications on a Private/Public/Hybrid Cloud. Aneka CAP offers facilities for quickly developing Cloud applications and a modular platform where additional services can be easily integrated to extend the system capabilities, thus being at pace with the rapidly ev...

  12. Benzonorbornadiene end caps for PMR resins

    Science.gov (United States)

    Panigot, Michael J.; Waters, John F.; Varde, Uday; Sutter, James K.; Sukenik, Chaim N.

    1992-01-01

    Several ortho-disubstituted benzonorbornadiene derivatives are described. These molecules contain acid, ester, or anhydride functionality permitting their use as end caps in PMR (polymerization of monomer reactants) polyimide systems. The replacement of the currently used norbornenyl end caps with benzonorbornadienyl end caps affords resins of increased aromatic content. It also allows evaluation of some mechanistic aspects of PMR cross-linking. Initial testing of N-phenylimide model compounds and of actual resin formulations using the benzonorbornadienyl end cap reveals that they undergo efficient thermal crosslinking to give oligomers with physical properties and thermal stability comparable to commercial norbornene-end-capped PMR systems.

  13. Studies of the Noise Risk Assessment and Management of Offshore Platform%海洋平台噪声风险评估与管理研究

    Institute of Scientific and Technical Information of China (English)

    孙刚; 余建星; 景海泳

    2013-01-01

    Studies concerning the analysis and control of the noise risk of offshore platform in our country are still at an initial stage.To study the impact on the offshore worker brought by the noise risks,a specific noise risk assessment system are of great significance should be established.Firstly,the sources of the noise of offshore platform should be classified and a noise function mechanism model was developed.On the basis of the model, the analytic hierarchy process and fuzzy comprehensive evaluation method were applied to the analysis of noise risk,which made the combinations of qualitative analysis and quantitative analysis, fuzzy mathematics and survey, workers' and experts' opinions,thus the noise management strategy were determined.According to the analysis result,the management recommendations were given which can minimize the noise risk and make sure that offshore oil is produced efficiently.%海洋平台噪声风险分析与管理研究在我国尚处于起步阶段,研究噪声风险对工作人员的影响并建立噪声风险评估体系具有重要意义.对海洋平台噪声风险源进行分类,提出噪声作用机制模型,在此基础上将层次分析法和模糊综合评判法引入噪声风险分析中,将定量分析和定性分析、模糊数学和调查统计、员工意见和专家意见相结合,从而制定海洋平台噪声风险管理策略.针对噪声风险分析结果,给出噪声管理建议,从而使海洋平台噪声风险降到最低,保证海洋石油生产活动高效进行.

  14. Robustness assessment of jacket platforms for progressive collapse under extreme environmental loading%极端环境下导管架平台连续倒塌鲁棒性评估

    Institute of Scientific and Technical Information of China (English)

    朱本瑞; 陈国明; 林红; 刘红兵; 胡春友

    2015-01-01

    The ultimate limit state and residual strength reserve ratio of jacket platforms were analyzed based on alternate path ( AP) and Pushover methods, and the influence of component types on platforms' anti-collapse capacity was investigated. The certainty indexes of WDSR , WRIF and WSRF were used to assess the robustness of jacket platforms as well as the importance of components. Considering the impact of environmental loading on the ultimate bearing capacity of jacket platforms, random plat-form reliability assessment method under random loading was established based on multi strips analysis ( MSA) and load se-quence incremental analysis (LSIA). Combining MSA and LSIA, a novel safety assessment figure (SAF) was proposed to e-valuate the safety of jacket platforms under full scale environmental loading. Further, probabilistic robustness of the platform was assessed utilizing probabilistic redundancy index. The results show that the resistance of the platform is not sensitive to the failure of horizontal bracings, which can be regarded as the redundant components because their deterministic robustness index is more significant. Diagonal bracings play an important role in ensuring the robustness of platform structures. The failure of this kind of components will affect the capacity of the platform. Therefore, it should be ensured that the strength and toughness are sufficient in the design of jacket platforms. The SAF introduced in this paper can improve the calculation precision of proba-bilistic robustness evaluation.%基于Pushover和AP法分析平台结构极限状态及剩余强度储备比,探讨不同类别承载模式的构件对平台结构抗倒塌能力的影响规律;采用WDSR、WRIF和WSRF确定性指标,评估平台结构鲁棒性和构件重要度.考虑平台抗力受环境载荷变化的影响,基于MSA和LSIA建立随机平台在随机载荷下的可靠度评估方法,提出导管架平台"安全评定图"概念,对服役平台全尺度载荷下的

  15. SERS sensors for DVD platform

    DEFF Research Database (Denmark)

    Brøgger, Anna Line

    This Ph.D. thesis explores the engineering of a portable sensor system for detection of rare and small molecules. The Ph.D. project is part of the research project 'Multi-Sensor DVD platform' (MUSE), aiming to integrate different sensors on a rotating disc. The sensors are chosen to complement each...... other, creating more reliable and stable results for the end user. The rotating disc comprises microfluidic channels, which can be utilized for handling and manipulating liquid samples such as blood or water. The focus of this Ph.D. thesis, is on the integration of one specific sensor on a rotating disc....... The sensor is based upon surface enhanced Raman spectroscopy (SERS), which detects molecular vibrations. The aim of this thesis is to cover the different aspects of the sensor system. SERS substrates, consisting of nanopillars with gold or silver caps on top, have been fabricated by standard micro and nano...

  16. Introduction of the human pro. cap alpha. 1(I) collagen gene into pro. cap alpha. 1(I)-deficient Mov-13 mouse cells leads to formation of functional mouse-human hybrid type I collagen

    Energy Technology Data Exchange (ETDEWEB)

    Schnieke, A.; Dziadek, M.; Bateman, J.; Mascara, T.; Harbers, K.; Gelinas, R.; Jaenisch, R.

    1987-02-01

    The Mov-13 mouse strain carries a retroviral insertion in the pro..cap alpha..1(I) collagen gene that prevents transcription of the gene. Cell lines derived from homozygous embryos do not express type I collagen although normal amounts of pro..cap alpha..2 mRNA are synthesized. The authors have introduced genomic clones of either the human or mouse pro..cap alpha..1(I) collagen gene into homozygous cell lines to assess whether the human or mouse pro..cap alpha..1(I) chains can associate with the endogenous mouse pro..cap alpha..2(I) chain to form stable type I collagen. The human gene under control of the simian virus 40 promoter was efficiently transcribed in the transfected cells. Protein analyses revealed that stable heterotrimers consisting of two human ..cap alpha..1 chains and one mouse ..cap alpha..2 chain were formed and that type I collagen was secreted by the transfected cells at normal rates. However, the electrophoretic migration of both ..cap alpha..1(I) and ..cap alpha..2(I) chains in the human-mouse hybrid molecules were retarded, compared to the ..cap alpha..(I) chains in control mouse cells. Inhibition of the posttranslational hydroxylation of lysine and proline resulted in comigration of human and mouse ..cap alpha..1 and ..cap alpha..2 chains, suggesting that increased posttranslational modification caused the altered electrophoretic migration in the human-mouse hybrid molecules. Amino acid sequence differences between the mouse and human ..cap alpha.. chains may interfere with the normal rate of helix formation and increase the degree of posttranslational modifications similar to those observed in patients with lethal perinatal osteogenesis imperfecta. The Mov-13 mouse system should allow the authors to study the effect specific mutations introduced in transfected pro..cap alpha..1(I) genes have on the synthesis, assembly, and function of collagen I.

  17. Photoluminescence quenching effect by Si cap in n+ Ge on Si

    Science.gov (United States)

    Pan, H.; Takahashi, R.; Takinai, K.; Wada, K.

    2015-02-01

    Monolithically integrated Ge lasers on Si have long been one of the biggest challenges for electronic and photonic integration on Si Complementary Metal Oxide Semiconductor (CMOS) platform. The "last one mile" is to reduce the threshold current of the electrically pumped Ge-on-Si laser. We have studied the growth of heavily doped n type (n+) Ge and analyzed its photoluminescence (PL) characteristics of Ge with a Si cap and thermal oxide layers. It is found that the PL intensity of n+ Ge was significantly reduced by the cap and etching off the cap showed a ~100% recovery to the intensity of n+ Ge without the cap. Thermally oxidized n+ Ge, on the other hand, showed a ~50% increase in the PL intensity of uncapped n+ Ge. These finding indicated that capping of n+ Ge introduces non-radiative recombination centers due to defects (dislocations) to reduce the PL intensity, while oxidation passivates surface defects remained even on uncapped n+ Ge. Considering these, we have designed and fabricated an electrically pumped n+ Ge light emitting diode with no Si cap layer but oxidation. A broad luminescence of Ge at 1500-1700 nm has been demonstrated but yet lasing not observed.

  18. ATLAS electromagnetic end-cap detector

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    After the insertion of the first end-cap into this cryostat, the team proceed to the wiring operations. Millions of wires are connected to the electromagnetic calorimeter on this end-cap, whch must be carefully fed out from the detector so that data can be read out. The energy of photons, electrons and positrons will be measured as they pass through the end-cap having been created along the line of the beams in the proton-proton collisions.

  19. Analysis of the function of the 70-kilodalton cyclase-associated protein (CAP) by using mutants of yeast adenylyl cyclase defective in CAP binding.

    Science.gov (United States)

    Wang, J; Suzuki, N; Nishida, Y; Kataoka, T

    1993-07-01

    In Saccharomyces cerevisiae, adenylyl cyclase forms a complex with the 70-kDa cyclase-associated protein (CAP). By in vitro mutagenesis, we assigned a CAP-binding site of adenylyl cyclase to a small segment near its C terminus and created mutants which lost the ability to bind CAP. CAP binding was assessed first by observing the ability of the overproduced C-terminal 150 residues of adenylyl cyclase to sequester CAP, thereby suppressing the heat shock sensitivity of yeast cells bearing the activated RAS2 gene (RAS2Val-19), and then by immunoprecipitability of adenylyl cyclase activity with anti-CAP antibody and by direct measurement of the amount of CAP bound. Yeast cells whose chromosomal adenylyl cyclase genes were replaced by the CAP-nonbinding mutants possessed adenylyl cyclase activity fully responsive to RAS2 protein in vitro. However, they did not exhibit sensitivity to heat shock in the RAS2Val-19 background. When glucose-induced accumulation of cyclic AMP (cAMP) was measured in these mutants carrying RAS2Val-19, a rapid transient rise indistinguishable from that of wild-type cells was observed and a high peak level and following persistent elevation of the cAMP concentration characteristic of RAS2Val-19 were abolished. In contrast, in the wild-type RAS2 background, similar cyclase gene replacement did not affect the glucose-induced cAMP response. These results suggest that the association with CAP, although not involved in the in vivo response to the wild-type RAS2 protein, is somehow required for the exaggerated response of adenylyl cyclase to activated RAS2.

  20. Collapse mechanisms and strength prediction of reinforced concrete pile caps

    DEFF Research Database (Denmark)

    Jensen, Uffe G.; Hoang, Linh Cao

    2012-01-01

    This paper describes an upper bound plasticity approach for strength prediction of reinforced concrete pile caps. A number of collapse mechanisms are identified and analysed. The procedure leads to an estimate of the load-carrying capacity and an identification of the critical collapse mechanism....... It is argued that the upper bound approach may be a useful complement to the widely used lower bound strut-and-tie method. Especially when dealing with strength assessment of existing structures....

  1. Thick methacrylate sections devoid of lost caps simplify stereological quantifications based on the optical fractionator design

    DEFF Research Database (Denmark)

    Andersen, Stine Hasselholt; Lykkesfeldt, Jens; Larsen, Jytte Overgaard

    2015-01-01

    Abstract In neuroscience, the optical fractionator technique is frequently used for unbiased cell number estimations. Although unbiased in theory, the practical application of the technique is often biased by the necessity of introducing a guard zone at one side of the disector to counter lost caps...... methacrylate) sections were inspected for lost caps to evaluate the possibility of whole section thickness counting with the optical fractionator technique and hippocampal granular cell nucleoli density differences along the z-axis were assessed with a z-axis analysis. No lost caps were found in the examined...

  2. Nature mangement, landscape and the CAP

    NARCIS (Netherlands)

    Brouwer, F.M.; Godeschalk, F.E.

    2004-01-01

    The integration of nature management, landscape and environmental concerns into the Common Agricultural Policy (CAP) has gained momentum with the CAP reforms adopted in June 2003. The report explores instruments and approaches that contribute to the inte-gration of nature conservation and landscape

  3. ALEPH end-cap and barrel

    CERN Multimedia

    Patrice Loiez

    1993-01-01

    The end-cap is pulled away from the barrel on the ALEPH detector so that the hadronic calorimeter and muon chambers are revealed. The end-cap maximises the data available from particles produced along the direction of the beam. The workers on the inner part of the detector give a sense of scale.

  4. Carbonate platform facies development of the Turonian Wata Formation in central and eastern Sinai, Egypt

    Science.gov (United States)

    Khalifa, M. A.; Farouk, S.; Hassan, A. M.

    2016-12-01

    The Wata carbonate platform in central and eastern Sinai show a clear pattern of evolutionary development during sedimentation. Three facies are recognized in the carbonate platform. Inner-platform in the south, inter-platform basin in the middle, and outer-platform in the northwest. Such classification was probably performed by the effect of Syrian Arc System that culminated during Turonian in Sinai. Inner-platform includes fining-upward cycles, each begins with packstone, followed by wackestone and capped by lime-mudstone or claystone or molluscan bioclastic wackestone at the base capped by sandy oolitic packstone or dolostone. The dominant faunal associations are molluscs, and echinoids. Inter-platform basin occurs north of inner-platform and extends northwest-southeast direction and comprises fining-upward cycles, each of which begins with bioclastic ostracodal packstone, calcisphere packstone, bioclastic packstone, capped by wackestone and lime-mudstone The faunal association includes, sponge spines, ostracodes, molluscan debris and calcispheres. They were deposited in shoal marine and barrier. The outer-platform occurs at Gebel Giddi and extended northwestwards. The lithofacies are entirely represented by calcisphere wackestone/packstone, with a reduced thickness of 20 m.

  5. Product Platform Screening at LEGO

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Steen Jensen, Thomas; Nielsen, Ole Fiil

    2012-01-01

    , and how do they assess if these candidates have enough potential to be worth implementing? Danish toy manufacturer LEGO has systematically gone through this process twice. The first time the results were poor; almost all platform candidates failed. The second time, though, has been largely successful...

  6. SW-platform for R&D in Applications of Synchrophasor Measurements for Wide-Area Assessment, Control and Visualization in Real-Time

    DEFF Research Database (Denmark)

    Jóhannsson, Hjörtur; Morais, Hugo; Pedersen, Allan Henning Birger

    2014-01-01

    realistic conditions, the future system scenarios are represented in a real time grid simulator that is an integrated part of the platform. The SW - platform provides structured access to any model parameter as well as access to real - time phasor measurement unit (PMU) and remote terminal unit (RTU......, training and demonstration of technologies within electric power and energy. More specifically, the SW - platform exploits the Intelligent Control Lab facilities in PowerLabDK, which provides access to a powerful Real - Time Digital Simulator, a SCAD A system, a full scale experimental power system control......The Danish research project “Secure Operation of Sustainable Power Systems (SOSPO)” is currently being conducted in a collaboration by a group of partners from academia and industry. The focus of the project is on how to achieve secure operation of the power grid as large scale thermal power plants...

  7. Ferromagnetism of polythiophene-capped Au nanoparticles

    Science.gov (United States)

    Suzuki, K.; Zhang, H.; Saito, K.; Garitaonandia, J. S.; Goikolea, E.; Insausti, M.

    2011-04-01

    The magnetic and electrical transport properties of regioregular poly(3-hexylthiophene)-capped Au nanoparticles (NPs) doped with iodine have been investigated to clarify the effectiveness of conductive polymer capping on the induction of ferromagnetism in Au. The room-temperature magnetization curve of the undoped polythiophene-capped Au NPs exhibits a clear hysteresis behavior with a coercive force of 160 Oe. The spontaneous magnetization normalized by the mass of Au is 2.0 × 10-2 emu/g. The spontaneous magnetization was found virtually unaffected by iodine doping, whereas the electrical conductivity is enhanced dramatically to ˜10 S/cm. Our results show that polythiophene capping could lead to spontaneous magnetic polarization in Au NPs, and the conductivity of the polymer capping does not affect the ferromagnetism of the Au nanoparticles, opening a possibility for further investigation into the magnetotransport behavior of ferromagnetic Au NPs.

  8. Reflection on Foreign Languages Network Teaching Platform

    Institute of Scientific and Technical Information of China (English)

    LIANG Yuan

    2014-01-01

    This paper aims to build awareness in applying foreign languages network teaching platform to higher education. Teachers rationally use foreign languages network teaching platform to hold an initiative concept, establish a cooperative and in-teractive learning atmosphere, and a prompt and dynamic assessment system.

  9. Google Search and the Law on Dominance in the EU : An Assessment of the Compatibility of Current Methodology with Multi-Sided Platforms in Online Search

    NARCIS (Netherlands)

    Herz, Martin

    2014-01-01

    Business platforms that utilise, or are based upon, internet technology are omnipresent in consumers daily lives. Since the dawn of the World Wide Web, the amount of web content has increased greatly. Simultaneously, business interests have sparked, meeting the arisen demand for particular online se

  10. Succinic acid production derived from carbohydrates: An energy and greenhouse gas assessment of a platform chemical toward a bio-based economy

    NARCIS (Netherlands)

    Cok, B.; Tsiropoulos, I.; Roes, A.L.; Patel, M.K.

    2014-01-01

    Bio-based succinic acid has the potential to become a platform chemical, i.e. a key building block for deriving both commodity and high-value chemicals, which makes it an attractive compound in a bio-based economy. A few companies and industrial consortia have begun to develop its industrial product

  11. Population Files for use with CAP88 at Los Alamos

    Energy Technology Data Exchange (ETDEWEB)

    McNaughton, Michael W [Los Alamos National Laboratory; Brock, Burgandy R [Los Alamos National Laboratory

    2012-07-10

    CAP88 (Clean Air Act Assessment Package 1988) is a computer model developed for the US Environmental Protection Agency to assess the potential dose from radionuclide emissions to air and to demonstrate compliance with the Clean Air Act. It has options to calculate either individual doses, in units of mrem, or a collective dose, also called population dose, in units of person-rem. To calculate the collective dose, CAP88 uses a population file such as LANL.pop, that lists the number of people in each sector (N, NNE, NE, etc.) as a function of distance (1 to 2 km, etc.) out to a maximum radius of 80 km. Early population files are described in the Los Alamos National Laboratory (LANL) Environmental Reports for 1985 (page 14) and subsequent years. LA-13469-MS describes a population file based on the 1990 census. These files have been updated several times, most recently in 2006 for CAP88 version 3. The 2006 version used the US census for 2000. The present paper describes the 2012 updates, using the 2010 census.

  12. Product Platform Modeling

    DEFF Research Database (Denmark)

    Pedersen, Rasmus

    on the notion that reuse and encapsulation of platform elements are fundamental characteristics of a product platform. Reuse covers the desire to reuse and share certain assets across a family of products and/or across generations of products. Product design solutions and principles are often regarded...... as important assets in a product platform, yet activities, working patterns, processes and knowledge can also be reused in a platform approach. Encapsulation is seen as a process in which the different elements of a platform are grouped into well defined and self-contained units which are decoupled from each......This PhD thesis has the title Product Platform Modelling. The thesis is about product platforms and visual product platform modelling. Product platforms have gained an increasing attention in industry and academia in the past decade. The reasons are many, yet the increasing globalisation...

  13. Use of a Novel Artificial Intelligence Platform on Mobile Devices to Assess Dosing Compliance in a Phase 2 Clinical Trial in Subjects With Schizophrenia

    Science.gov (United States)

    2017-01-01

    Background Accurately monitoring and collecting drug adherence data can allow for better understanding and interpretation of the outcomes of clinical trials. Most clinical trials use a combination of pill counts and self-reported data to measure drug adherence, despite the drawbacks of relying on these types of indirect measures. It is assumed that doses are taken, but the exact timing of these events is often incomplete and imprecise. Objective The objective of this pilot study was to evaluate the use of a novel artificial intelligence (AI) platform (AiCure) on mobile devices for measuring medication adherence, compared with modified directly observed therapy (mDOT) in a substudy of a Phase 2 trial of the α7 nicotinic receptor agonist (ABT-126) in subjects with schizophrenia. Methods AI platform generated adherence measures were compared with adherence inferred from drug concentration measurements. Results The mean cumulative pharmacokinetic adherence over 24 weeks was 89.7% (standard deviation [SD] 24.92) for subjects receiving ABT-126 who were monitored using the AI platform, compared with 71.9% (SD 39.81) for subjects receiving ABT-126 who were monitored by mDOT. The difference was 17.9% (95% CI -2 to 37.7; P=.08). Conclusions Using drug levels, this substudy demonstrates the potential of AI platforms to increase adherence, rapidly detect nonadherence, and predict future nonadherence. Subjects monitored using the AI platform demonstrated a percentage change in adherence of 25% over the mDOT group. Subjects were able to use the technology successfully for up to 6 months in an ambulatory setting with early termination rates that are comparable to subjects outside of the substudy. Trial Registration ClinicalTrials.gov NCT01655680 https://clinicaltrials.gov/ct2/show/NCT01655680?term=NCT01655680 PMID:28223265

  14. The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests.

    Science.gov (United States)

    Mathaes, Roman; Mahler, Hanns-Christian; Buettiker, Jean-Pierre; Roehl, Holger; Lam, Philippe; Brown, Helen; Luemkemann, Joerg; Adler, Michael; Huwyler, Joerg; Streubel, Alexander; Mohl, Silke

    2016-02-01

    Parenteral drug products are protected by appropriate primary packaging to protect against environmental factors, including potential microbial contamination during shelf life duration. The most commonly used CCS configuration for parenteral drug products is the glass vial, sealed with a rubber stopper and an aluminum crimp cap. In combination with an adequately designed and controlled aseptic fill/finish processes, a well-designed and characterized capping process is indispensable to ensure product quality and integrity and to minimize rejections during the manufacturing process. In this review, the health authority requirements and expectations related to container closure system quality and container closure integrity are summarized. The pharmaceutical vial, the rubber stopper, and the crimp cap are described. Different capping techniques are critically compared: The most common capping equipment with a rotating capping plate produces the lowest amount of particle. The strength and challenges of methods to control the capping process are discussed. The residual seal force method can characterize the capping process independent of the used capping equipment or CCS. We analyze the root causes of several cosmetic defects associated with the vial capping process.

  15. Capping stack: An industry in the making

    Institute of Scientific and Technical Information of China (English)

    Jack Chen; Li Xunke; Xie Wenhui; Kang Yongtian

    2013-01-01

    This paper gives an overview of recent development of the marine well containment system (MWCS)after BP Macondo subsea well blowout occurred on April 20,2010 in the Gulf of Mexico.Capping stack,a hardware utilized to contain blowout well at or near the wellhead is the center piece of MWCS.Accessibility to the dedicated capping stacks is gradually becoming a pre-requirement to obtain the permit for offshore drilling/workover,and the industry for manufacturing,maintenance,transportation and operation of the capping stack is in the making.

  16. Disc-Capped ZnO Nanocombs

    Institute of Scientific and Technical Information of China (English)

    LI Xin; XU chun-xiang; ZHU Guang-Ping; YANG Yi; LIU Jin-Ping; SUN Xiao-Wei; CUI Yi-Ping

    2007-01-01

    Nanocombs with a disc cap structure of ZnO have been synthesized on si substrates by using pure Zinc powders as the source materials based on a vapour-phase transport process.The morphology and the microstructure are investigated by a scanning electron microscopy and x-ray diffraction.Based on the transmission electron microscopy and selected area electron diffraction analysis,the growth directions of three representative parts,nanoribbon stem,nanorod branch and nanodisc cap of the nanocomb are revealed.The growth mechanism of the disc-capped nanocombs is discussed based on the self-catalyzed vapour-liquid-solid process.

  17. Continuous Platform Development

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil

    low risks and investments but also with relatively fuzzy results. When looking for new platform projects, it is important to make sure that the company and market is ready for the introduction of platforms, and to make sure that people from marketing and sales, product development, and downstream......, but continuous product family evolution challenges this strategy. The concept of continuous platform development is based on the fact that platform development should not be a one-time experience but rather an ongoing process of developing new platforms and updating existing ones, so that product family...... evolution does not make the platforms irrelevant. This research is based on case studies and applications in the two Danish companies, LEGO and Grundfos, where several platform development projects have been followed. LEGO is exceptional for their long experience with platform development and maintenance...

  18. Mechanisms of nerve capping technique in prevention of painful neuroma formation.

    Directory of Open Access Journals (Sweden)

    Hede Yan

    Full Text Available Nerve capping techniques have been introduced as a promising treatment modality for the treatment of painful neuroma with varied outcomes; however, its exact mechanism is still unknown. RhoA is one of the members of the RAS superfamily of GTPases that operate as molecular switches and plays an important role in peripheral nerve regeneration. Our aim was to investigate the structural and morphologic mechanisms by which the nerve capping technique prevents the formation of painful neuromas after neuroectomy. We also hoped to provide a theoretical basis for this treatment approach. An aligned nanofiber conduit was used for the capping procedure and the sciatic nerve of Sprague-Dawley rats was selected as the animal model. Behavioral analysis, extent of neuroma formation, histological assessment, expressions of pain markers of substance P and c-fos, molecular biological changes as well as ultrastructural features were investigated and compared with the findings in a no-capping control group. The formation of traumatic neuromas was significantly inhibited in the capping group with relatively "normal" structural and morphological features and no occurrence of autotomy and significantly lower expression of pain markers compared to the no-capping group. The gene expression of RhoA was consistently in a higher level in the capping group within 8 weeks after surgery. This study shows that capping technique will alter the regeneration state of transected nerves and reduce painful neuroma formation, indicating a promising approach for the treatment of painful neuroma. The initiation of the "regenerative brake" induced by structural as well as morphological improvements in the severed nerve is theorized to be most likely a key mechanism for the capping technique in the prevention of painful neuroma formation.

  19. An accuracy assessment of the CALIOP/CALIPSO version 2 aerosol extinction product based on a detailed multi-sensor, multi-platform case study

    OpenAIRE

    Kacenelenbogen, M.; VAUGHAN, M.A.; Redemann, J.; Hoff, R. M.; R. R. Rogers; Ferrare, R. A.; P. B. Russell; Hostetler, C. A.; J. W. Hair; Holben, B.N.

    2010-01-01

    The Cloud Aerosol LIdar with Orthogonal Polarization (CALIOP), on board the CALIPSO platform, has measured profiles of total attenuated backscatter coefficient (level 1 products) since June 2006. CALIOP's level 2 products, such as the aerosol backscatter and extinction coefficient profiles, are retrieved using a complex succession of automated algorithms. The goal of this study is to help identify potential shortcomings in the CALIOP version 2 level 2 aerosol extinction product and to il...

  20. C-CAP Land Cover, Kauai, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  1. C-CAP Land Cover, Maui, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  2. C-CAP Land Cover, Molokai, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  3. C-CAP Land Cover, Lanai, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  4. Circumpolar Active-Layer Permafrost System (CAPS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Circumpolar Active-Layer Permafrost System (CAPS) contains over 100 data sets pertaining to permafrost and frozen ground topics. It also contains detailed...

  5. C-CAP Hawaii 2005 Land Cover

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  6. Cryopyrin-Associated Autoinflammatory Syndromes (CAPS) - Juvenile

    Science.gov (United States)

    ... of the nervous system, including headaches and deafness. CAPS are not contagious. Treatments that block interleukin-1, an important molecule involved in the inflammatory process, are very effective. To prevent permanent damage, treatment ...

  7. C-CAP Land Cover, Niihau, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  8. C-CAP Niihau 2005 Land Cover

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land cover derived from high resolution imagery according to the Coastal Change Analysis Program (C-CAP) protocol. This data set utilized 1...

  9. Mobile platform security

    CERN Document Server

    Asokan, N; Dmitrienko, Alexandra

    2013-01-01

    Recently, mobile security has garnered considerable interest in both the research community and industry due to the popularity of smartphones. The current smartphone platforms are open systems that allow application development, also for malicious parties. To protect the mobile device, its user, and other mobile ecosystem stakeholders such as network operators, application execution is controlled by a platform security architecture. This book explores how such mobile platform security architectures work. We present a generic model for mobile platform security architectures: the model illustrat

  10. Platform development supportedby gaming

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan; Hansen, Poul H. Kyvsgård

    2007-01-01

    The challenge of implementing industrial platforms in practice can be described as a configuration problem caused by high number of variables, which often have contradictory influences on the total performance of the firm. Consequently, the specific platform decisions become extremely complex......, based on the portfolio management thinking, to measure the degree of modularity embedded in a given platform and to what extent it is aligned with other platforms....

  11. Atmospheric metallic and arsenic pollution at an offshore drilling platform in the Bo Sea: A health risk assessment for the workers.

    Science.gov (United States)

    Xu, Hong; Han, Suqin; Bi, Xiaohui; Zhao, Zhijing; Zhang, Lei; Yang, Wenjie; Zhang, Min; Chen, Jing; Wu, Jianhui; Zhang, Yufen; Feng, Yinchang

    2016-03-05

    To investigate the ambient metal pollution at the offshore drilling platform in the Bo Sea, which few studies have focused on, PM2.5 samples were collected and ten heavy metals, as well as As, were analyzed. High concentration levels of metals were observed, and the heavy metal pollution was quite serious compared to air quality standards and other marine areas. Back trajectories and wind dependent and PCA analyses showed that the marine sources included ship traffic emissions and corrosive stainless steels from the equipment at the platform as well as industrial emissions from stainless steel production and coal combustion sources, which were transported from the surrounding mainland. Both contributed greatly to the ambient metallic particles at the offshore platform. The Hazard Index values of the metals, which were much less than 1, the Carcinogenic Risk data, which were lower than the EPA's acceptable range, and the fact that the metal concentrations did not the exceed the permissible exposure limits of OSHA, indicated that the health risks from the ambient metallic particles for the oil-drilling workers were not significant.

  12. Righting an ATLAS end-cap

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Each component of the giant ATLAS detector must be moved and transported with great caution so that delicate components are not damaged. Therefore, tests are performed, like the one shown. The end-cap weighs 160 tonnes, making the delicate moving process a non-trivial feat. A special crane and supports have been designed so that the end-cap can be raised using a pivot.

  13. Design and implementation of the CAPS receiver

    Science.gov (United States)

    Hu, Yonghui; Hua, Yu; Hou, Lei; Wei, Jingfa; Wu, Jianfeng

    2009-03-01

    In this paper, based on analyses of the Chinese Area Positioning System (CAPS) satellite (GEO satellite) resources and signal properties, the signal power at the port of the receiver antenna is estimated, and the implementation projects are presented for a switching band C to band L CAPS C/A code receiver integrated with GPS receiver suite and for a CAPS dual frequency P code receiver. A microstrip receiving antenna is designed with high sensitivity and wide beam orientation, the RF front end of the C/A code and P code receivers, and a processor is designed for the navigation baseband. A single frequency CAPS C/A code receiver and a CAPS dual frequency P code receiver are built at the same time. A software process flow is provided, and research on relatively key techniques is also conducted, such as signal searching, code loop and carrier loop algorithms, a height assistant algorithm, a dual frequency difference speed measurement technique, a speed measurement technique using a single frequency source with frequency assistance, and a CAPS time correcting algorithm, according to the design frame of the receiver hardware. Research results show that the static plane positioning accuracy of the CAPS C/A code receiver is 20.5-24.6 m, height accuracy is 1.2-12.8 m, speed measurement accuracy is 0.13-0.3 m/s, dynamic plane positioning accuracy is 24.4 m, height accuracy is 3.0 m, and speed measurement accuracy is 0.24 m/s. In the case of C/A code, the timing accuracy is 200 ns, and it is also shown that the positioning accuracy of the CAPS precise code receiver (1 σ) is 5 m from south to north, and 0.8 m from east to west. Finally, research on positioning accuracy is also conducted.

  14. Design and implementation of the CAPS receiver

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this paper, based on analyses of the Chinese Area Positioning System (CAPS) satellite (GEO satellite) resources and signal properties, the signal power at the port of the receiver antenna is estimated, and the implementation projects are presented for a switching band C to band L CAPS C/A code receiver integrated with GPS receiver suite and for a CAPS dual frequency P code receiver. A microstrip receiving antenna is designed with high sensitivity and wide beam orientation, the RF front end of the C/A code and P code receivers, and a processor is designed for the navigation baseband. A single frequency CAPS C/A code receiver and a CAPS dual frequency P code receiver are built at the same time. A software process flow is provided, and research on relatively key techniques is also conducted, such as signal searching, code loop and carrier loop algorithms, a height assistant algorithm, a dual frequency difference speed measurement technique, a speed measurement technique using a single frequency source with frequency assistance, and a CAPS time correcting algorithm, according to the design frame of the receiver hardware. Research results show that the static plane positioning accuracy of the CAPS C/A code receiver is 20.5-24.6 m, height accuracy is 1.2-12.8 m, speed measurement accuracy is 0.13-0.3 m/s, dynamic plane positioning accuracy is 24.4 m, height accuracy is 3.0 m, and speed measurement accuracy is 0.24 m/s. In the case of C/A code, the timing accuracy is 200 ns, and it is also shown that the positioning accuracy of the CAPS precise code receiver (1σ ) is 5 m from south to north, and 0.8 m from east to west. Finally, research on positioning accuracy is also conducted.

  15. ITS Platform North Denmark

    DEFF Research Database (Denmark)

    Lahrmann, Harry; Agerholm, Niels; Juhl, Jens;

    2012-01-01

    This paper presents the project entitled “ITS Platform North Denmark” which is used as a test platform for Intelligent Transportation System (ITS) solutions. The platform consists of a newly developed GNSS/GPRS On Board Unit (OBU) to be installed in 500 cars, a backend server and a specially...

  16. 42 CFR 418.309 - Hospice cap amount.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Hospice cap amount. 418.309 Section 418.309 Public...) MEDICARE PROGRAM HOSPICE CARE Payment for Hospice Care § 418.309 Hospice cap amount. The hospice cap amount... until October 31 of the following year. (b) Each hospice's cap amount is calculated by the...

  17. Towards a Market Entry Framework for Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan

    2016-01-01

    (i.e., issuing evolutionary and revolutionary payment instruments). The studied cases reveal that digital platforms leverage payment services as a mean to bridge and converge core and adjacent platform markets. In so doing, platform envelopment strengthens firms’ market position in their respective......This study presents a framework to understand and explain the design and configuration of digital payment platforms and how these platforms create conditions for market entries. By embracing the theoretical lens of platform envelopment, we employed a multiple and comparative-case study...... in a European setting by using our framework as an analytical lens to assess market-entry conditions. We found that digital payment platforms have acquired market entry capabilities, which is achieved through strategic platform design (i.e., platform development and service distribution) and technology design...

  18. Ability of combined Near-Infrared Spectroscopy-Intravascular Ultrasound (NIRS-IVUS) imaging to detect lipid core plaques and estimate cap thickness in human autopsy coronary arteries

    Science.gov (United States)

    Grainger, S. J.; Su, J. L.; Greiner, C. A.; Saybolt, M. D.; Wilensky, R. L.; Raichlen, J. S.; Madden, S. P.; Muller, J. E.

    2016-03-01

    The ability to determine plaque cap thickness during catheterization is thought to be of clinical importance for plaque vulnerability assessment. While methods to compositionally assess cap integrity are in development, a method utilizing currently available tools to measure cap thickness is highly desirable. NIRS-IVUS is a commercially available dual imaging method in current clinical use that may provide cap thickness information to the skilled reader; however, this is as yet unproven. Ten autopsy hearts (n=15 arterial segments) were scanned with the multimodality NIRS-IVUS catheter (TVC Imaging System, Infraredx, Inc.) to identify lipid core plaques (LCPs). Skilled readers made predictions of cap thickness over regions of chemogram LCP, using NIRS-IVUS. Artery segments were perfusion fixed and cut into 2 mm serial blocks. Thin sections stained with Movat's pentachrome were analyzed for cap thickness at LCP regions. Block level predictions were compared to histology, as classified by a blinded pathologist. Within 15 arterial segments, 117 chemogram blocks were found by NIRS to contain LCP. Utilizing NIRSIVUS, chemogram blocks were divided into 4 categories: thin capped fibroatheromas (TCFA), thick capped fibroatheromas (ThCFA), pathological intimal thickening (PIT)/lipid pool (no defined cap), and calcified/unable to determine cap thickness. Sensitivities/specificities for thin cap fibroatheromas, thick cap fibroatheromas, and PIT/lipid pools were 0.54/0.99, 0.68/0.88, and 0.80/0.97, respectively. The overall accuracy rate was 70.1% (including 22 blocks unable to predict, p = 0.075). In the absence of calcium, NIRS-IVUS imaging provided predictions of cap thickness over LCP with moderate accuracy. The ability of this multimodality imaging method to identify vulnerable coronary plaques requires further assessment in both larger autopsy studies, and clinical studies in patients undergoing NIRS-IVUS imaging.

  19. Methodology for development of risk indicators for offshore platforms

    Energy Technology Data Exchange (ETDEWEB)

    Oeien, K.; Sklet, S. [SINTEF Industrial Management Safety and Reliability (Norway)

    1999-09-01

    This paper presents a generic methodology for development of risk indicators for petroleum installations and a specific set of risk indicators established for one offshore platform. The risk indicators should be used to control the risk during operation of platforms. The methodology is purely risk-based and the basis for development of risk indicators is the platform specific quantitative risk analysis (QRA). In order to identify high risk contributing factors, platform personnel are asked to assess whether and how much the risk influencing factors will change. A brief comparison of probabilistic safety assessment (PSA) for nuclear power plants and quantitative risk analysis (QRA) for petroleum platforms is also given. (au)

  20. Research on informational operation application of tactical loitering platform

    Science.gov (United States)

    Wang, Huanhuan; Zhang, Jun; Li, Guoshu; Song, Jinxing; Zhang, Yunhao

    2016-11-01

    The tactical loitering platform, as a multifunctional precision guided weapon, is an important part of constitution of information warfare. Using the combined propulsion system, the flying mode of platform includes supersonic cruise and subsonic loiter. With different loads, the platform is information warfare equipments with functions of region spying, communication control, electronic jamming, target tracking, accurate attack and damage assessment. Also the ability of platform can be enforced by using data link system in the informational operation.

  1. 75 FR 49527 - Caps Visual Communications, LLC; Black Dot Group; Formerly Known as Caps Group Acquisition, LLC...

    Science.gov (United States)

    2010-08-13

    ... Employment and Training Administration Caps Visual Communications, LLC; Black Dot Group; Formerly Known as... Adjustment Assistance on June 24, 2010, applicable to workers of Caps Visual Communications, LLC, Black Dot..., Caps Visual Communications, LLC, Black Dot Group, formerly known as Caps Group Acquisition,...

  2. Platform evolution studies

    Science.gov (United States)

    Walton, Barbara A.

    1990-01-01

    The polar orbiting platform (POP), being developed by the Work Package 3 (WP3) Project at the Goddard Space Flight Center, will play a key role in the NASA Leadership Initiative, Mission to Planet Earth (MPE). It becomes, with the addition of payloads, an Earth observation satellite observatory. Mission to Planet Earth also has geostationary platforms (GEOP) as part of its global observational system. A study was begun in March 1988 to assess the applicability of the POP orbital replacement units (ORUs) for a geostationary Earth observing mission. Two test cases, representative of MPE payloads, were studied. Case A was used to emphasize the GEOP configuration and design; it used a Titan/Centaur to achieve orbit. Case B, considered to be much further in the future, included some assembly at the Space Station Freedom manned base and use of an orbital transfer vehicle to achieve orbit; requirements on the manned base to support such a mission were emphasized. The study found the POP systems more than adequate to meet GEOP requirements. Two types of changes were required for the POP ORUs: (1) modification to use only one surface for heat rejection; for the battery ORU, this meant 'opening up' the ORU to retain the radiator area with a corresponding decrease in depth; and (2) deletion of equipment not needed. The Case A configuration was shown to be within the planned capability of the Titan IV/Centaur. Assembly requirements were included for the Case B configuration, which is driven by the large microwave antennas of two of the payloads. The final review was April 19, 1989.

  3. Scenarios for a cap beyond 2013; Implications for EU27 agriculture and the cap budget

    NARCIS (Netherlands)

    Helming, J.F.M.; Terluin, I.J.

    2011-01-01

    An ex ante analysis of a set of five policy components (proposed post 2013 CAP measures) has been carried out for the 2014-2020 period, based on the EC Communication The CAP towards 2020 of 18 November 2010. The policy components are defined in such a way that they focus on the contribution of farme

  4. Storage of cellular 5' mRNA caps in P bodies for viral cap-snatching.

    Science.gov (United States)

    Mir, M A; Duran, W A; Hjelle, B L; Ye, C; Panganiban, A T

    2008-12-09

    The minus strand and ambisense segmented RNA viruses include multiple important human pathogens and are divided into three families, the Orthomyxoviridae, the Bunyaviridae, and the Arenaviridae. These viruses all initiate viral transcription through the process of "cap-snatching," which involves the acquisition of capped 5' oligonucleotides from cellular mRNA. Hantaviruses are emerging pathogenic viruses of the Bunyaviridae family that replicate in the cytoplasm of infected cells. Cellular mRNAs can be actively translated in polysomes or physically sequestered in cytoplasmic processing bodies (P bodies) where they are degraded or stored for subsequent translation. Here we show that the hantavirus nucleocapsid protein binds with high affinity to the 5' cap of cellular mRNAs, protecting the 5' cap from degradation. We also show that the hantavirus nucleocapsid protein accumulates in P bodies, where it sequesters protected 5' caps. P bodies then serve as a pool of primers during the initiation of viral mRNA synthesis by the viral polymerase. We propose that minus strand segmented viruses replicating in the cytoplasm have co-opted the normal degradation machinery of P bodies for storage of cellular caps. Our data also indicate that modification of the cap-snatching model is warranted to include a role for the nucleocapsid protein in cap acquisition and storage.

  5. Long-Term Outdoor Reliability Assessment of a Wireless Unit for Air-Quality Monitoring Based on Nanostructured Films Integrated on Micromachined Platforms

    Directory of Open Access Journals (Sweden)

    Massimiliano Decarli

    2012-06-01

    Full Text Available We have fabricated and tested in long-term field operating conditions a wireless unit for outdoor air quality monitoring. The unit is equipped with two multiparametric sensors, one miniaturized thermo-hygrometer, front-end analogical and digital electronics, and an IEEE 802.15.4 based module for wireless data transmission. Micromachined platforms were functionalized with nanoporous metal-oxides to obtain multiparametric sensors, hosting gas-sensitive, anemometric and temperature transducers. Nanoporous metal-oxide layer was directly deposited on gas sensing regions of micromachined platform batches by hard-mask patterned supersonic cluster beam deposition. An outdoor, roadside experiment was arranged in downtown Milan (Italy, where one wireless sensing unit was continuously operated side by side with standard gas chromatographic instrumentation for air quality measurements. By means of a router PC, data from sensing unit and other instrumentation were collected, merged, and sent to a remote data storage server, through an UMTS device. The whole-system robustness as well as sensor dataset characteristics were continuously characterized over a run-time period of 18 months.

  6. Chemostratigraphy and lithological characters of Neoproterozoic cap carbonates from the Kuruktag Mountain, Xinjiang, western China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The Neoproterozoic Era includes some of the most largest ice ages in the geological history.The exact number of glaciations is unknown,though there were at least two events of global glaciation.Neoproterozoic glacial deposits in the Kurukmg Mountain,Xinjiang,western China have proven that there had occurred three discrete Neoproterozoic glaciations.Diamictite units occurred in the Bassi,Tereeken,and Hankalchough formations,carbonate units were recognized among the diamictites and immediately overlied the Bayisi,Tereeken and Hankalchough diamictites.Carbonates at the top of the Bayisi Formation are characterized by the dolo-sility stones with negative δ13C values ranging from-4.10‰ to-8.17‰(PDB),comparable to the Sturtian cap carbonates that overlie the Sturtian glacial deposits from other Neoproterozoic sequences.Carbonates overlying the Tereeken Formation are characterized by the pinkish cap dolostones fca.10 m thick)with negative δ13C values railging from -2.58‰ to-4.77‰(PDB),comparable to the Marinoan cap carbonates,The cap is alao characterized by tepee-like structures,barite precipitates and pseudomorphous aragonite crystal fan limestones.Carbonates at the top of the Hankalchough Formation are characterized by subaerial exposure crust(vadose pisolite structure,calcareous crust structure)dolostones with negative δ13C values ranging from-4.56‰δto-11.45‰(PDB)and the calcareous crust dolostones,implying that the Hankalchough cap carbonates differ from either the Sturtian or Marinoan cap carbonates in sedimentary environment and carbon isotopic composition.In addition,it is suggested the Hankalchough glaciation belongs to a terrestrial glaciation and it is the third largest glaciation during the Neoproterozoic period on the Tarim platform.

  7. Martian north polar cap summer water cycle

    CERN Document Server

    Brown, Adrian J; Becerra, Patricio; Byrne, Shane

    2016-01-01

    A key outstanding question in Martian science is 'are the polar caps gaining or losing mass and what are the implications for past, current and future climate?' To address this question, we use observations from the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) of the north polar cap during late summer for multiple Martian years, to monitor the summertime water cycle in order to place quantitative limits on the amount of water ice deposited and sublimed in late summer. We establish here for the first time the summer cycle of water ice absorption band signatures on the north polar cap. We show that in a key region in the interior of the north polar cap, the absorption band depths grow until Ls=120, when they begin to shrink, until they are obscured at the end of summer by the north polar hood. This behavior is transferable over the entire north polar cap, where in late summer regions 'flip' from being net sublimating into net condensation mode. This transition or 'mode flip' happens earlier for ...

  8. Analysis on the positioning precision of CAPS

    Institute of Scientific and Technical Information of China (English)

    JI YuanFa; SUN XiYan

    2009-01-01

    As a newly developed satellite positioning system,the Chinese Area Positioning System (CAPS) Is a typical direct sequence spread spectrum ranging system like GPS.The positioning precision of such navigation signals depends on many factors,including the pseudo-code rate,the signal to noise ratio,the processing methods for tracking loops and so on.This paper describes the CAPS link budget,the solution approach for CAPS positioning,focusing on the autocorrelation function feature of C/A code signals.The CAPS signal measurement precision is studied by the software approach together with theoretical analysis of the range resolution.Because the conventional Delay Lock Loop (DLL) is vulnerable to the impact of noise,a narrow correlator and multiple correlatore as well as the corresponding discrimination methods of phases are proposed,which improves the robustness of DLL and the code-phase resolution of the measurement.The results show that the Improvement of the DLL structure and the discrimination method are the most important way to improve the ranging resolution.Theoretical analysis and experimental results show that a CAPS receiver could reach a 20-m positioning precision by using three satellites with a supported height from an altimeter.

  9. Analysis on the positioning precision of CAPS

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    As a newly developed satellite positioning system, the Chinese Area Positioning System (CAPS) is a typical direct sequence spread spectrum ranging system like GPS. The positioning precision of such navigation signals depends on many factors, including the pseudo-code rate, the signal to noise ratio, the processing methods for tracking loops and so on. This paper describes the CAPS link budget, the solution approach for CAPS positioning, focusing on the autocorrelation function feature of C/A code signals. The CAPS signal measurement precision is studied by the software approach together with theoretical analysis of the range resolution. Because the conventional Delay Lock Loop (DLL) is vul- nerable to the impact of noise, a narrow correlator and multiple correlators as well as the corresponding discrimination methods of phases are proposed, which improves the robustness of DLL and the code-phase resolution of the measurement. The results show that the improvement of the DLL structure and the discrimination method are the most important way to improve the ranging resolution. Theoretical analysis and experimental results show that a CAPS receiver could reach a 20-m positioning precision by using three satellites with a supported height from an altimeter.

  10. Platform switching and bone platform switching.

    Science.gov (United States)

    Carinci, Francesco; Brunelli, Giorgio; Danza, Matteo

    2009-01-01

    Bone platform switching involves an inward bone ring in the coronal part of the implant that is in continuity with the alveolar bone crest. Bone platform switching is obtained by using a dental fixture with a reverse conical neck. A retrospective study was performed to evaluate the effectiveness of conventional vs reverse conical neck implants. In the period between May 2004 and November 2007, 86 patients (55 females and 31 males; median age, 53 years) were operated and 234 implants were inserted: 40 and 194 were conventional vs reverse conical neck implants, respectively. Kaplan-Meier algorithm and Cox regression were used to detect those variables associated with the clinical outcome. No differences in survival and success rates were detected between conventional vs reverse conical neck implants alone or in combination with any of the studied variables. Although bone platform switching leads to several advantages, no statistical difference in alveolar crest resorption is detected in comparison with reverse conical neck implants. We suppose that the proximity of the implant abutment junction to the alveolar crestal bone gives no protection against the microflora contained in the micrograph. Additional studies on larger series and a combination of platform switching and bone platform switching could lead to improved clinical outcomes.

  11. Interconnection of Communities of Practice: A Web Platform for Knowledge Management

    CERN Document Server

    Garrot-Lavoué, Elise

    2012-01-01

    Our works aim at developing a Web platform to connect various Communities of Practice (CoPs) and to capitalise on all their knowledge. This platform addresses CoPs interested in a same general activity, for example tutoring. For that purpose, we propose a general model of Interconnection of Communities of Practice (ICP), based on the concept of Constellation of Practice (CCP) developed by Wenger (1998). The model of ICP was implemented and has been used to develop the TE-Cap 2 platform which has, as its field of application, educational tutoring activities. In particular, we propose an indexation and search tool for the ICP knowledge base. The TE-Cap 2 platform has been used in real conditions. We present the main results of this descriptive investigation to validate this work.

  12. Dynamic Interaction between Cap & Trade and Electricity Markets

    Science.gov (United States)

    Jeev, Kumar

    Greenhouse Gases (GHG), such as Carbon-Dioxide (CO2), which is released in the atmosphere due to anthropogenic activities like power production, are now accepted as the main culprits for global warming. The Regional Greenhouse Gas Initiative (RGGI), an initiative of the North East and Mid-Atlantic States of the United States (US) for limiting the emission of GHG, has developed a regional cap-and-trade program for CO2 emissions for power plants. Existing cap-and-trade programs in US and Europe for Greenhouse Gases have recently been plagued by over-allocation. Carbon prices recently collapsed in all these markets during the global recession. Since then, there have been significant policy changes, which have resulted in the adoption of aggressive emission cap targets by most major carbon emission markets. This is expected to make carbon emissions availability more restrictive, raising the prices of these credits. These emissions markets are expected to have a major impact on the wholesale electricity markets. Two models to study the interaction of these two markets are presented. These models assess the impact of the emissions market on wholesale electricity prices. The first model characterizes the competition between two types of power plants (coal and gas) in both the electricity and emissions markets as a dynamic game using the Cournot approximation. Under this approximation, we find that in the Nash equilibrium the plants increase their permit allocation to high-demand periods and the marginal value of each credit for a plant is identical in all periods under their optimal equilibrium strategy. The second numerical model allows us to explicitly evaluate the closed loop equilibrium of the dynamic interaction of two competitors in these markets. We find that plants often try to corner the market and push prices all the way to the price cap. Power plants derive most of their profits from these extreme price regimes. In the experiments where trading is allowed

  13. DFH-3 Satellite Platform

    Institute of Scientific and Technical Information of China (English)

    RenShufang

    2005-01-01

    The DFH-3 satellite platform is designed and developed by China Academy of Space Technology (CAST). It is a medium capability communications satellite platform. The platform adopts threeaxis attitude stabilization control system, having solar array output power of 1.7kW by the end of its design lifetime of 8 years. Its mass is 2100kg with payload capacity of 220kg.

  14. Product Platform Replacements

    DEFF Research Database (Denmark)

    Sköld, Martin; Karlsson, Christer

    2012-01-01

    Purpose – It is argued in this article that too little is known about product platforms and how to deal with them from a manager's point of view. Specifically, little information exists regarding when old established platforms are replaced by new generations in R&D and production environments...... originality and value is achieved by focusing on product platform replacements believed to represent a growing management challenge....

  15. Seismic explosion sources on an ice cap

    DEFF Research Database (Denmark)

    Shulgin, Alexey; Thybo, Hans

    2015-01-01

    Controlled source seismic investigation of crustal structure below ice covers is an emerging technique. We have recently conducted an explosive refraction/wide-angle reflection seismic experiment on the ice cap in east-central Greenland. The data-quality is high for all shot points and a full...... as a strong ice wave. The ice cap leads to low transmission of energy into the crust such that charges need be larger than in conventional onshore experiments to obtain reliable seismic signals. The strong reflection coefficient at the base of the ice generates strong multiples which may mask for secondary...... phases. This effect may be crucial for acquisition of reflection seismic profiles on ice caps. Our experience shows that it is essential to use optimum depth for the charges and to seal the boreholes carefully....

  16. Assessing the Influence of Climate Extremes on Ecosystems and Human Health in Southwestern Amazon Supported by the PULSE-Brazil Platform

    DEFF Research Database (Denmark)

    Aragão, Luiz E O C; Marengo, Jose; Cox, Peter

    2016-01-01

    -environmental disasters such as the impacts of droughts and consequent increases in fire detections on the incidence of respiratory diseases, and 2) evaluating the impacts of temperature increases in combination with rainfall seasonality upon the incidence of Dengue fever. Based on data available in PULSE-Brazil platform...... a conceptual pathway for promoting the interaction between science and policy during the process of producing a tool that allows the understating of climate-relate processes. Our results clearly demonstrated that ecosystems are under increased fire risk in the future that will, in turn, affect the health...... region. We expect that PULSE-Brazil will serve not only as a technical tool for supporting governance, management, mitigation and long-term adaptation plans for climate impacts and natural disasters, but also will take advantage of its graphical capabilities to be an instructive vehicle that facilitates...

  17. NeuroVR 1.5 - a free virtual reality platform for the assessment and treatment in clinical psychology and neuroscience.

    Science.gov (United States)

    Riva, Giuseppe; Carelli, Laura; Gaggioli, Andrea; Gorini, Alessandra; Vigna, Cinzia; Corsi, Riccardo; Faletti, Gianluca; Vezzadini, Luca

    2009-01-01

    At MMVR 2007 we presented NeuroVR (http://www.neurovr.org) a free virtual reality platform based on open-source software. The software allows non-expert users to adapt the content of 14 pre-designed virtual environments to the specific needs of the clinical or experimental setting. Following the feedbacks of the 700 users who downloaded the first version, we developed a new version - NeuroVR 1.5 - that improves the possibility for the therapist to enhance the patient's feeling of familiarity and intimacy with the virtual scene, by using external sounds, photos or videos. Specifically, the new version now includes full sound support and the ability of triggering external sounds and videos using the keyboard. The outcomes of different trials made using NeuroVR will be presented and discussed.

  18. Omnidirectional holonomic platforms

    Energy Technology Data Exchange (ETDEWEB)

    Pin, F.G.; Killough, S.M.

    1994-06-01

    This paper presents the concepts for a new family of wheeled platforms which feature full omnidirectionality with simultaneous and independently controlled rotational and translational motion capabilities. The authors first present the orthogonal-wheels concept and the two major wheel assemblies on which these platforms are based. They then describe how a combination of these assemblies with appropriate control can be used to generate an omnidirectional capability for mobile robot platforms. The design and control of two prototype platforms are then presented and their respective characteristics with respect to rotational and translational motion control are discussed.

  19. The Creative Platform

    DEFF Research Database (Denmark)

    Byrge, Christian; Hansen, Søren

    This book is about introducing more creativity into general educational courses and cross-disciplinary activities. It is directed toward teachers at all levels in the educational system, but the Creative Platform is a general model, and thus the creative process will fundamentally be the same...... whether you consider thirdgrade teaching, human-resource development, or radical new thinking in product development in a company. The Creative Platform was developed at Aalborg University through a series of research-and-development activities in collaboration with educational institutions and private...... you can use in your work with the Creative Platform. This book is intended as an introduction on how to use the Creative Platform....

  20. Martian north polar cap summer water cycle

    Science.gov (United States)

    Brown, Adrian J.; Calvin, Wendy M.; Becerra, Patricio; Byrne, Shane

    2016-10-01

    A key outstanding question in Martian science is "are the polar caps gaining or losing mass and what are the implications for past, current and future climate?" To address this question, we use observations from the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) of the north polar cap during late summer for multiple Martian years, to monitor the summertime water cycle in order to place quantitative limits on the amount of water ice deposited and sublimed in late summer. We establish here for the first time the summer cycle of water ice absorption band signatures on the north polar cap. We show that in a key region in the interior of the north polar cap, the absorption band depths grow until Ls = 120, when they begin to shrink, until they are obscured at the end of summer by the north polar hood. This behavior is transferable over the entire north polar cap, where in late summer regions 'flip' from being net sublimating into net condensation mode. This transition or 'mode flip' happens earlier for regions closer to the pole, and later for regions close to the periphery of the cap. The observations and calculations presented herein estimate that on average a water ice layer ∼70 microns thick is deposited during the Ls = 135-164 period. This is far larger than the results of deposition on the south pole during summer, where an average layer 0.6-6 microns deep has been estimated by Brown et al. (2014) Earth Planet. Sci. Lett., 406, 102-109.

  1. Assembling the CMS yoke end-caps

    CERN Multimedia

    Laurent Guiraud

    2001-01-01

    A crane is used to piece together one of the end-caps that will provide the path for magnetic flux return on the CMS experiment. A total of six end-cap discs will be assembled before being positioned on the barrel yoke to complete the huge 12 500 tonne cylinder yoke. The magnetic field produced will be greater than any other solenoid created to date at 4 T, 100 000 times greater than the Earth's natural magnetic field, and will store enough energy to melt 18 tonnes of gold.

  2. Pharmacy benefit caps and the chronically ill.

    Science.gov (United States)

    Joyce, Geoffrey F; Goldman, Dana P; Karaca-Mandic, Pinar; Zheng, Yuhui

    2007-01-01

    In this paper we examine medication use among retirees with employer-sponsored drug coverage both with and without annual benefit limits. We find that pharmacy benefit caps are associated with higher rates of medication discontinuation across the most common therapeutic classes and that only a minority of those who discontinue use reinitiate therapy once coverage resumes. Plan members who reach their cap are more likely than others to switch plans and increase their rate of generic use; however, in most cases, the shift is temporary. Given the similarities between these plans and Part D, we make some inferences about reforms for Medicare.

  3. Design and implementation of the CAPS receiver

    Institute of Scientific and Technical Information of China (English)

    HU YongHui; HUA Yu; HOU Lei; WEI JingFa; WU JianFeng

    2009-01-01

    In this paper,baaed on analyses of the Chinese Area Positioning System (CAPS) satellite (GEO satellite) resources and signal properties,the signal power at the port of the receiver antenna is estimated,and the implementation projects are presented for a switching band C to band L CAPS C/A code receiver integrated with GPS receiver suite and for a CAPS dual frequency P code receiver.A microstrip receiving antenna is designed with high sensitivity and wide beam orientation,the RF front end of the C/A code and P code receivers,and a processor is designed for the navigation baseband.A single frequency CAPS C/A code receiver and a CAPS dual frequency P code receiver are built at the same time.A software process flow is provided,and research on relatively key techniques is also conducted,such as signal searching,code loop and carrier loop algorithms,a height assistant algorithm,a dual frequency difference speed measurement technique,a speed measurement technique using a single frequency source with frequency assistance,and a CAPS time correcting algorithm,according to the design frame of the receiver hardware.Research results show that the static plane positioning accuracy of the CAPS C/A code receiver is 20.5-24.6 m,height accuracy is 1.2-12.8 m,speed measurement accuracy is 0.13-0.3 m/s,dynamic plane positioning accuracy is 24.4 m,height accuracy is 3.0 m,and speed measurement accuracy is 0.24 m/s.In the case of C/A code,the timing accuracy is 200 ha,and it is also shown that the positioning accuracy of the CAPS precise code receiver (1σ) is 5 m from south to north,and 0.8 m from east to west.Finally,research on positioning accuracy is also conducted.

  4. SNP2CAPS: a SNP and INDEL analysis tool for CAPS marker development

    OpenAIRE

    Thiel, Thomas; Kota, Raja; Grosse, Ivo; Stein, Nils; Graner, Andreas

    2004-01-01

    With the influx of various SNP genotyping assays in recent years, there has been a need for an assay that is robust, yet cost effective, and could be performed using standard gel-based procedures. In this context, CAPS markers have been shown to meet these criteria. However, converting SNPs to CAPS markers can be a difficult process if done manually. In order to address this problem, we describe a computer program, SNP2CAPS, that facilitates the computational conversion of SNP markers into CA...

  5. Development of an efficient amine-functionalized glass platform by additional silanization treatment with alkylsilane.

    Science.gov (United States)

    Kamisetty, Nagendra Kumar; Pack, Seung Pil; Nonogawa, Mitsuru; Devarayapalli, Kamakshaiah Charyulu; Kodaki, Tsutomu; Makino, Keisuke

    2006-11-01

    Aminosilane-treated molecular layers on glass surfaces are frequently used as functional platforms for biosensor preparation. All the amino groups present on the surface are not available in reactive forms, because surface amino groups interact with remaining unreacted surface silanol groups. Such nonspecific interactions might reduce the efficiency of chemical immobilization of biomolecules such as DNA, enzymes, antibodies, etc., in biosensor fabrication. To improve immobilization efficiency we have used additional surface silanization with alkylsilane (capping) to convert the remaining silanol groups into Si-O-Si linkages, thereby liberating the amino groups from nonspecific interaction with the silanol groups. We prepared different types of capped amine surface and evaluated the effect of capping on immobilization efficiency by investigating the fluorescence intensity of Cy3-NHS (N-hydroxysuccinimide) dye that reacted with amino groups. The results indicate that most of the capped amine surfaces resulted in enhanced efficiency of immobilization of Cy3-NHS compared with the untreated control amine surface. We found a trend that trialkoxysilanes had greater capping effects on immobilization efficiency than monoalkoxysilanes. It was also found that the aliphatic chain of alkylsilane, which does not participate in the capping of the silanol, had an important function in enhancing immobilization efficiency. These results would be useful for preparation of an amine-modified surface platform, with enhanced immobilization efficiency, which is essential for developing many kinds of biosensors on a silica matrix.

  6. Climate News Across Media Platforms

    DEFF Research Database (Denmark)

    Eskjær, Mikkel Fugl

    2015-01-01

    In a changing media landscape marked by technological, institutional and cultural convergence, comparative and cross-media content analysis represents a valuable analytical tool in mapping the diverse channels of climate change communication. This paper presents a comparative study of climate...... change news on five different media platforms: newspapers, television, radio, web-news and mobile news. It investigates the themes and actors represented in public climate change communication as well as the diverse possibilities of participating in public debates and information sharing. By combining...... quantitative and qualitative content analysis the paper documents and explores the extent and character of climate change news across different media platforms. The study aims at contributing to the on-going assessment of how news media are addressing climate change at a time when old and new media...

  7. ALTERNATE REDUCTANT COLD CAP EVALUATION FURNACE PHASE II TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F.; Stone, M.; Miller, D.

    2014-09-03

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further research and development of this flowsheet eliminated the formic acid, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric-glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP):  Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the CEF cold cap and vapor space data to the benchmark melter flammability models;  Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: o Define new cold cap reactions and global kinetic parameters in support of the melter flammability model development; o Quantify off-gas surging potential of the feed; o Characterize off-gas condensate for complete organic and inorganic carbon species. After charging the CEF with cullet from Phase I CEF testing, the melter was slurry-fed with glycolic flowsheet based SB6-Frit 418 melter feed at 36

  8. Alternate Reductant Cold Cap Evaluation Furnace Phase II Testing

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F. C. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Stone, M. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Miller, D. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2014-09-03

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further research and development of this flowsheet eliminated the formic acid, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric-glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP): Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the CEF cold cap and vapor space data to the benchmark melter flammability models; Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: Define new cold cap reactions and global kinetic parameters in support of the melter flammability model development; Quantify off-gas surging potential of the feed; Characterize off-gas condensate for complete organic and inorganic carbon species. After charging the CEF with cullet from Phase I CEF testing, the melter was slurry-fed with glycolic flowsheet based SB6-Frit 418 melter feed at 36% waste

  9. Chemostratigraphy of the Neoproterozoic Mirassol d'Oeste cap dolostones (Mato Grosso, Brazil): An alternative model for Marinoan cap dolostone formation

    Science.gov (United States)

    Font, E.; Nédélec, A.; Trindade, R. I. F.; Macouin, M.; Charrière, A.

    2006-10-01

    We have conducted a detailed study of the Neoproterozoic Mirassol d'Oeste cap dolostones that overlay the glacial diamictites of the Puga Formation (˜ 635 Ma, Amazon craton, Brazil) in order to understand the formation of these post-glacial dolostones. Petrographic features indicate that the dolostones are primary to early diagenetic in origin and precipitated in a moderately shallow-water platform corresponding to a carbonate ramp during transgressive conditions. Major and trace element contents, as well as C and O isotopic signatures, are consistent with an anoxic sediment influenced by sulphate-reducing bacteria. Such an environment is known to provide favourable conditions for the precipitation of dolomite as observed nowadays in modern hypersaline lagoons. Isotopic compositions of tube-like structures suggest local upward fluid seepage from the underlying cap dolostone. Our data concur with geochemical data from other Neoproterozoic cap dolostones to support a microbially-mediated model in specific environmental conditions for the formation of these unusual deposits worldwide.

  10. Product Platform Performance

    DEFF Research Database (Denmark)

    Munk, Lone

    of components (often around 50%) and • reduced production cost and investments (often around 25%). This verifies a significant, general improvement potential, a verification which has lacked in the literature. These findings underline the potential in platform-based product development as a way of creating......The aim of this research is to improve understanding of platform-based product development by studying platform performance in relation to internal effects in companies. Platform-based product development makes it possible to deliver product variety and at the same time reduce the needed resources......, and the subject has gained increased attention in industry and academia the past decade. Literature on platform-based product development is often based on single case studies and it is sparsely verified if expected effects are achieved. This makes it difficult to put forward realistic expectations for companies...

  11. Assessment of postpartum rehabilitation using Glazer assessment scheme with biofeedback therapy instrument as platform%以生物反馈治疗仪为平台的Glazer法评估产后康复情况

    Institute of Scientific and Technical Information of China (English)

    罗伟; 任艳蕊; 易绍媛; 刘锋

    2015-01-01

    目的:采用Glazer评估的生物反馈治疗仪诊断产妇产后盆底肌肉受损的程度,进而科学地指导医生通过电刺激和生物反馈对患者实施精准地康复治疗.方法:选取2011年6月~2013年6月该院妇产科收治的产妇897例,分为观察组(450例)和对照组(447例),对所有研究对象进行压力检测.观察组进行电刺激和生物反馈治疗,对照组给予常规盆底肌功能锻炼.采用MyoTrac infiniti公司的SA9800型生物反馈治疗仪对Ⅰ、Ⅱ型肌纤维功能进行评估.治疗3个月后比较两组产妇的盆底肌张力、阴道肌电压以及尿失禁发生率.结果:观察组产妇阴道肌电压情况显著改善、盆底肌力强度增加、产妇尿失禁发生率显著降低、尿失禁症状明显改善,与对照组比较,差异有统计学意义(P<0.05).结论:采用SA9800型生物反馈治疗仪配合Glazer评估诊断可对患者治疗起到指导作用.在Glazer评估的标准下,可以量化测定盆底肌力和盆底肌肉受损的程度.经过正确康复治疗,可以帮助产妇提高盆底肌张力,降低尿失禁发生率,有效减少产后常见疾病的发生率.%Objective:To diagnose the degree of postpartum pelvic floor muscle damage using Glazer assessment scheme with biofeedback therapy instrument as platform,scientifically guide physicians to provide precise rehabilitation therapy through electrical stimulation and biofeedback.Methods:A total of 897 postpartum women treated in Department of Gynecology and Obstetrics in the hospital from June 2011 to June 2013 were selected and divided into observation group (450 women) and control group (447 women),pressure measurement was performed among all the women.The women in observation group were treated with electrical stimulation and biofeedback therapy,while the women in control group were treated with routine pelvic floor muscle function training.SA9800 type biofeedback therapy apparatus (Myo-Trac infiniti Company) was used to

  12. Knowledge Management at Cap Gemini Nederland

    NARCIS (Netherlands)

    M.J. Vlaanderen (Marie Jose)

    1998-01-01

    textabstractThe theme of this paper is knowledge management (KM) at an organization that provides information technology (IT) services. It is based on the results of a KM-survey of the Finance Division of Cap Gemini (CG) conducted during the spring of 1997.

  13. Mapping of p140Cap phosphorylation sites

    DEFF Research Database (Denmark)

    Repetto, Daniele; Aramu, Simona; Boeri Erba, Elisabetta;

    2013-01-01

    Protein phosphorylation tightly regulates specific binding of effector proteins that control many diverse biological functions of cells (e. g. signaling, migration and proliferation). p140Cap is an adaptor protein, specifically expressed in brain, testis and epithelial cells, that undergoes phosp...

  14. The Effectiveness of Caps on Political Lobbying

    NARCIS (Netherlands)

    Matejka, M.; Onderstal, A.M.; De Waegenaere, A.M.B.

    2002-01-01

    In this paper, we analyze a lobby game, modelled as an all-pay auction in which interest groups submit bids in order to obtain a political prize.The bids are restricted to be below a cap imposed by the government.For both an incomplete and a complete information setting we show the following results

  15. CAP Reform and the Doha Development Agenda

    NARCIS (Netherlands)

    van Dijck, P.; Faber, G.

    2004-01-01

    The CAP reforms that the EU accepted in June 2003 will partially decouple direct income payments to farmers from production and make these payments conditional on cross-compliance. The reforms are driven by enlargement of EU membership, budgetary constraints, mounting pressures from diverse animal w

  16. ATLAS: End-cap Toroid assembly

    CERN Multimedia

    2006-01-01

    In building 191 and building 180- assembly of this massive piece.To reach the top of the end-cap the cranes has to be used and during the assembly you can see welding and hear many tools running background.

  17. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.

    Science.gov (United States)

    Jockusch, Wolf J; Speidel, Dina; Sigler, Albrecht; Sørensen, Jakob B; Varoqueaux, Frederique; Rhee, Jeong-Seop; Brose, Nils

    2007-11-16

    Before transmitter-filled synaptic vesicles can fuse with the plasma membrane upon stimulation they have to be primed to fusion competence. The regulation of this priming process controls the strength and plasticity of synaptic transmission between neurons, which in turn determines many complex brain functions. We show that CAPS-1 and CAPS-2 are essential components of the synaptic vesicle priming machinery. CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, which causes a selective impairment of fast phasic transmitter release. Increases in the intracellular Ca(2+) levels can transiently revert this defect. Our findings demonstrate that CAPS proteins generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2+) triggered release of transmitters.

  18. 'Cooling Caps' May Halt Chemo-Linked Hair Loss

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163580.html 'Cooling Caps' May Halt Chemo-Linked Hair Loss One ... 2017 TUESDAY, Feb. 14, 2017 (HealthDay News) -- Scalp cooling caps can help breast cancer patients save their ...

  19. Facially amphiphilic thiol capped gold and silver nanoparticles

    Indian Academy of Sciences (India)

    Shreedhar Bhata; Uday Maitra

    2008-11-01

    A series of bile acid-derived facially amphiphilic thiols have been used to cap sliver and gold nanoparticles. The self-assembling properties of these steroid-capped nanoparticles have been investigated and reported in this article.

  20. An accuracy assessment of the CALIOP/CALIPSO version 2 aerosol extinction product based on a detailed multi-sensor, multi-platform case study

    Directory of Open Access Journals (Sweden)

    M. Kacenelenbogen

    2010-11-01

    Full Text Available The Cloud Aerosol LIdar with Orthogonal Polarization (CALIOP, on board the CALIPSO platform, has measured profiles of total attenuated backscatter coefficient (level 1 products since June 2006. CALIOP's level 2 products, such as the aerosol backscatter and extinction coefficient profiles, are retrieved using a complex succession of automated algorithms. The goal of this study is to help identify potential shortcomings in the CALIOP version 2 level 2 aerosol extinction product and to illustrate some of the motivation for the changes that will be introduced in the next version of CALIOP data (version 3, currently being processed. As a first step, we compared CALIOP version 2-derived AOD with the collocated MODerate Imaging Spectroradiometer (MODIS AOD retrievals over the Continental United States. The best statistical agreement between those two quantities was found over the Eastern part of the United States with, nonetheless, a weak correlation (R ~0.4 and an apparent CALIOP version 2 underestimation (by ~66% of MODIS AOD. To help quantify the potential factors contributing to the uncertainty of the CALIOP aerosol extinction retrieval, we then focused on a one-day, multi-instrument, multiplatform comparison study during the CALIPSO and Twilight Zone (CATZ validation campaign on August 04, 2007. This case study illustrates the following potential reasons for a bias in the CALIOP AOD: (i CALIOP's low signal-to-noise ratio (SNR leading to the misclassification and/or lack of aerosol layer identification, especially close to the Earth's surface; (ii the cloud contamination of CALIOP version 2 aerosol backscatter and extinction profiles; (iii potentially erroneous assumptions of the backscatter-to-extinction ratio (Sa used in CALIOP's extinction retrievals; and (iv calibration coefficient biases in the CALIOP daytime attenuated backscatter coefficient profiles.

  1. PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment. Recommendations from a joint EPAA - EURL ECVAM ADME workshop.

    NARCIS (Netherlands)

    Bessems, Jos G.; Loizou, George; Krishnan, Kannan; Clewell, Harvey J.; Bernasconi, Camilla; Bois, Frederic; Coecke, Sandra; Collnot, Eva Maria; Diembeck, Walter; Farcal, Lucian Romeo; Geraets, Liesbeth; Gundert-Remy, Ursula; Kramer, Nynke; Küsters, Gabriele; Leite, Sofia B.; Pelkonen, Olavi R.; Schröder, Klaus; Testai, Emanuela; Wilk-Zasadna, Iwona; Zaldívar-Comenges, José Manuel

    2014-01-01

    Information on toxicokinetics is critical for animal-free human risk assessment. Human external exposure must be translated into human tissue doses and compared with in vitro actual cell exposure associated to effects (in vitro-in vivo comparison). Data on absorption, distribution, metabolism and ex

  2. Student Performance and Success Factors in Learning Business Statistics in Online vs. On-Ground Classes Using a Web-Based Assessment Platform

    Science.gov (United States)

    Shotwell, Mary; Apigian, Charles H.

    2015-01-01

    This study aimed to quantify the influence of student attributes, coursework resources, and online assessments on student learning in business statistics. Surveys were administered to students at the completion of both online and on-ground classes, covering student perception and utilization of internal and external academic resources, as well as…

  3. The Common HOL Platform

    OpenAIRE

    Adams, Mark

    2015-01-01

    The Common HOL project aims to facilitate porting source code and proofs between members of the HOL family of theorem provers. At the heart of the project is the Common HOL Platform, which defines a standard HOL theory and API that aims to be compatible with all HOL systems. So far, HOL Light and hol90 have been adapted for conformance, and HOL Zero was originally developed to conform. In this paper we provide motivation for a platform, give an overview of the Common HOL Platform's theory and...

  4. Ladder attachment platform

    Science.gov (United States)

    Swygert,; Richard, W [Springfield, SC

    2012-08-28

    A ladder attachment platform is provided that includes a base for attachment to a ladder that has first and second side rails and a plurality of rungs that extend between in a lateral direction. Also included is a user platform for having a user stand thereon that is carried by the base. The user platform may be positioned with respect to the ladder so that it is not located between a first plane that extends through the first side rail and is perpendicular to the lateral direction and a second plane that extends through the second side rail and is perpendicular to the lateral direction.

  5. CMS end-cap yoke at the detector's assembly site.

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The magnetic flux generated by the superconducting coil in the CMS detector is returned via an iron yoke comprising three end-cap discs at each end (end-cap yoke) and five concentric cylinders (barrel yoke). This picture shows the first of three end-cap discs (red) seen through the outer cylinder of the vacuum tank which will house the superconducting coil.

  6. Developing a social media platform for nurses.

    Science.gov (United States)

    Jackson, Jennifer; Kennedy, Maggie

    2015-11-18

    Social media tools provide opportunities for nurses to connect with colleagues and patients and to advance personally and professionally. This article describes the process of developing an innovative social media platform at a large, multi-centre teaching hospital, The Ottawa Hospital, Canada, and its benefits for nurses. The platform, TOH Nurses, was developed using a nursing process approach, involving assessment, planning, implementation and evaluation. The aim of this initiative was to address the barriers to communication inherent in the large number of nurses employed by the organisation, the physical size of the multi-centre hospital and the shift-work nature of nursing. The platform was used to provide educational materials for clinical nurses, and to share information about professional practice. The implications of using a social media platform in a healthcare setting were considered carefully during its development and implementation, including concerns regarding privacy and confidentiality.

  7. Platform-based production development

    DEFF Research Database (Denmark)

    Bossen, Jacob; Brunoe, Thomas Ditlev; Nielsen, Kjeld

    2015-01-01

    Platforms as a means for applying modular thinking in product development is relatively well studied, but platforms in the production system has until now not been given much attention. With the emerging concept of platform-based co-development the importance of production platforms is though...... indisputable. This paper presents state-of-the-art literature on platform research related to production platforms and investigates gaps in the literature. The paper concludes on findings by proposing future research directions....

  8. Mass changes in Arctic ice caps and glaciers: implications of regionalizing elevation changes

    DEFF Research Database (Denmark)

    Nilsson, Johan; Sørensen, Louise Sandberg; Barletta, Valentina Roberta;

    2015-01-01

    The mass balance of glaciers and ice caps is sensitive to changing climate conditions. The mass changes derived n this study are determined from elevation changes derived measured by the Ice, Cloud, and land Elevation Satellite (ICESat) for the time period 2003–2009. Four methods, based on interp......The mass balance of glaciers and ice caps is sensitive to changing climate conditions. The mass changes derived n this study are determined from elevation changes derived measured by the Ice, Cloud, and land Elevation Satellite (ICESat) for the time period 2003–2009. Four methods, based...... of the regional mass balance of Arctic ice caps and glaciers to different regionalization schemes. The sensitivity analysis is based on studying the spread of mass changes and their associated errors, and the suitability of the different regionalization techniques is assessed through cross validation.The cross...

  9. Measuring Psychological Capital: Construction and Validation of the Compound PsyCap Scale (CPC-12.

    Directory of Open Access Journals (Sweden)

    Timo Lorenz

    Full Text Available With the Psychological Capital Questionnaire (PCQ being the standard measure to assess psychological capital (PsyCap in the context of organizations, this paper aims to broaden this domain-specific approach by introducing a measure with universal claim. Two studies were conducted to create and validate a German self-report scale (CPC-12 measuring PsyCap. We performed confirmatory factor analyses and correlations with other positive psychological constructs on the data of two German samples (N1 = 321; N2 = 202. The twelve-item CPC-12 exhibits the anticipated factorial structure with a very good model fit and associations to other constructs concur with previous findings with other measures of PsyCap.

  10. Measuring Psychological Capital: Construction and Validation of the Compound PsyCap Scale (CPC-12).

    Science.gov (United States)

    Lorenz, Timo; Beer, Clemens; Pütz, Jan; Heinitz, Kathrin

    2016-01-01

    With the Psychological Capital Questionnaire (PCQ) being the standard measure to assess psychological capital (PsyCap) in the context of organizations, this paper aims to broaden this domain-specific approach by introducing a measure with universal claim. Two studies were conducted to create and validate a German self-report scale (CPC-12) measuring PsyCap. We performed confirmatory factor analyses and correlations with other positive psychological constructs on the data of two German samples (N1 = 321; N2 = 202). The twelve-item CPC-12 exhibits the anticipated factorial structure with a very good model fit and associations to other constructs concur with previous findings with other measures of PsyCap.

  11. Modeling of inactivation of surface borne microorganisms occurring on seeds by cold atmospheric plasma (CAP)

    Science.gov (United States)

    Mitra, Anindita; Li, Y.-F.; Shimizu, T.; Klämpfl, Tobias; Zimmermann, J. L.; Morfill, G. E.

    2012-10-01

    Cold Atmospheric Plasma (CAP) is a fast, low cost, simple, easy to handle technology for biological application. Our group has developed a number of different CAP devices using the microwave technology and the surface micro discharge (SMD) technology. In this study, FlatPlaSter2.0 at different time intervals (0.5 to 5 min) is used for microbial inactivation. There is a continuous demand for deactivation of microorganisms associated with raw foods/seeds without loosing their properties. This research focuses on the kinetics of CAP induced microbial inactivation of naturally growing surface microorganisms on seeds. The data were assessed for log- linear and non-log-linear models for survivor curves as a function of time. The Weibull model showed the best fitting performance of the data. No shoulder and tail was observed. The models are focused in terms of the number of log cycles reduction rather than on classical D-values with statistical measurements. The viability of seeds was not affected for CAP treatment times up to 3 min with our device. The optimum result was observed at 1 min with increased percentage of germination from 60.83% to 89.16% compared to the control. This result suggests the advantage and promising role of CAP in food industry.

  12. Quantitative correlation of the effect of process conditions on the capping tendencies of tablet formulations.

    Science.gov (United States)

    Akseli, Ilgaz; Stecuła, Adrian; He, Xiaorong; Ladyzhynsky, Nadia

    2014-06-01

    Capping is a mechanical defect in tablet formulation and manufacture. Understanding what influences tablet capping in terms of process variables and formulation properties and developing specialized techniques to correlate these variables with mechanical failures are practical interests of the pharmaceutical industry. Tablet compression emulator was used to rank order capping tendencies of a diverse sample set. The compression forces of 5-25 kN were used to compress round, beveled edge, and oval shape tablets. Compression speeds of 25, 40, and 80 rpm were chosen as representative ranges for bench-to-manufacturing-scale processing. Tablets were tested by in-house developed nondestructive ultrasonic method. The measurements revealed that elastic modulus vary with different testing orientations that indicated elastic modulus anisotropy in tablets. It was shown that altering process conditions such as tooling, compression force, and compression speed significantly impact the capping tendencies of formulations. A systematic approach has been applied to develop a predictive tool to assess capping tendencies of formulations. The developed tool is fast, material sparing, and has potential to flag the risk of manufacturability issues and provide insight into the performance of formulations during early development.

  13. A Framework for Assessing Soil Moisture Deficit and Crop Water Stress at Multiple Space and Time Scales Under Climate Change Scenarios Using Model Platform, Satellite Remote Sensing, and Decision Support System

    KAUST Repository

    Mohanty, Binayak P.

    2016-11-03

    Better understanding of water cycle at different space–time scales would be a key for sustainable water resources, agricultural production, and ecosystems health in the twenty-first century. Efficient agricultural water management is necessary for sustainability of the growing global population. This warrants better predictive tools for aridity (based on precipitation, temperature, land use, and land cover), root zone (~top 1 m) soil moisture deficit, and crop water stress at farm, county, state, region, and national level, where decisions are made to allocate and manage the water resources. It will provide useful strategies for not only efficient water use but also for reducing potential risk of crop failure due to agricultural drought. Leveraging heavily on ongoing multiscale hydrologic modeling, data assimilation, soil moisture dynamics, and inverse model development research activities, and ongoing Land Data Assimilation (LDAS) and National Climate Assessment (NCA) indexing efforts we are developing a drought assessment framework. The drought assessment platform includes: (1) developing disaggregation methods for extracting various field-scale (1-km or less) climate indicators from the (SMOS, VIIRS, SMAP, AMSR-2) satellite / LDAS-based soil moisture in conjunction with a multimodel simulation–optimization approach using ensemble of Soil Vegetation Atmosphere Transfer, SVAT (Noah, CLM, VIC, Mosaic in LIS) models; (2) predicting farm/field-scale long-term root zone soil moisture status under various land management and climate scenarios for the past decades in hindcast mode and for the next decades in forecast mode across the USA using effective land surface parameters and meteorological input from Global Circulation Model (GCM) outputs; (3) assessing the potential risk of agricultural drought at different space–time scales across the USA based on predicted root zone soil moisture; and (4) evaluating various water management and cropping practices (e

  14. An accuracy assessment of the CALIOP/CALIPSO version 2/version 3 daytime aerosol extinction product based on a detailed multi-sensor, multi-platform case study

    Directory of Open Access Journals (Sweden)

    M. Kacenelenbogen

    2011-04-01

    Full Text Available The Cloud Aerosol LIdar with Orthogonal Polarization (CALIOP, on board the CALIPSO platform, has measured profiles of total attenuated backscatter coefficient (level 1 products since June 2006. CALIOP's level 2 products, such as the aerosol backscatter and extinction coefficient profiles, are retrieved using a complex succession of automated algorithms. The goal of this study is to help identify potential shortcomings in the CALIOP version 2 level 2 aerosol extinction product and to illustrate some of the motivation for the changes that have been introduced in the next version of CALIOP data (version 3, released in June 2010. To help illustrate the potential factors contributing to the uncertainty of the CALIOP aerosol extinction retrieval, we focus on a one-day, multi-instrument, multiplatform comparison study during the CALIPSO and Twilight Zone (CATZ validation campaign on 4 August 2007. On that day, we observe a consistency in the Aerosol Optical Depth (AOD values recorded by four different instruments (i.e. space-borne MODerate Imaging Spectroradiometer, MODIS: 0.67 and POLarization and Directionality of Earth's Reflectances, POLDER: 0.58, airborne High Spectral Resolution Lidar, HSRL: 0.52 and ground-based AErosol RObotic NETwork, AERONET: 0.48 to 0.73 while CALIOP AOD is a factor of two lower (0.32 at 532 nm. This case study illustrates the following potential sources of uncertainty in the CALIOP AOD: (i CALIOP's low signal-to-noise ratio (SNR leading to the misclassification and/or lack of aerosol layer identification, especially close to the Earth's surface; (ii the cloud contamination of CALIOP version 2 aerosol backscatter and extinction profiles; (iii potentially erroneous assumptions of the aerosol extinction-to-backscatter ratio (Sa used in CALIOP's extinction retrievals; and (iv calibration coefficient biases in the CALIOP daytime attenuated backscatter coefficient profiles. The use of version 3 CALIOP extinction

  15. An accuracy assessment of the CALIOP/CALIPSO version 2/version 3 daytime aerosol extinction product based on a detailed multi-sensor, multi-platform case study

    Science.gov (United States)

    Kacenelenbogen, M.; Vaughan, M. A.; Redemann, J.; Hoff, R. M.; Rogers, R. R.; Ferrare, R. A.; Russell, P. B.; Hostetler, C. A.; Hair, J. W.; Holben, B. N.

    2011-04-01

    The Cloud Aerosol LIdar with Orthogonal Polarization (CALIOP), on board the CALIPSO platform, has measured profiles of total attenuated backscatter coefficient (level 1 products) since June 2006. CALIOP's level 2 products, such as the aerosol backscatter and extinction coefficient profiles, are retrieved using a complex succession of automated algorithms. The goal of this study is to help identify potential shortcomings in the CALIOP version 2 level 2 aerosol extinction product and to illustrate some of the motivation for the changes that have been introduced in the next version of CALIOP data (version 3, released in June 2010). To help illustrate the potential factors contributing to the uncertainty of the CALIOP aerosol extinction retrieval, we focus on a one-day, multi-instrument, multiplatform comparison study during the CALIPSO and Twilight Zone (CATZ) validation campaign on 4 August 2007. On that day, we observe a consistency in the Aerosol Optical Depth (AOD) values recorded by four different instruments (i.e. space-borne MODerate Imaging Spectroradiometer, MODIS: 0.67 and POLarization and Directionality of Earth's Reflectances, POLDER: 0.58, airborne High Spectral Resolution Lidar, HSRL: 0.52 and ground-based AErosol RObotic NETwork, AERONET: 0.48 to 0.73) while CALIOP AOD is a factor of two lower (0.32 at 532 nm). This case study illustrates the following potential sources of uncertainty in the CALIOP AOD: (i) CALIOP's low signal-to-noise ratio (SNR) leading to the misclassification and/or lack of aerosol layer identification, especially close to the Earth's surface; (ii) the cloud contamination of CALIOP version 2 aerosol backscatter and extinction profiles; (iii) potentially erroneous assumptions of the aerosol extinction-to-backscatter ratio (Sa) used in CALIOP's extinction retrievals; and (iv) calibration coefficient biases in the CALIOP daytime attenuated backscatter coefficient profiles. The use of version 3 CALIOP extinction retrieval for our case

  16. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  17. The Common HOL Platform

    Directory of Open Access Journals (Sweden)

    Mark Adams

    2015-07-01

    Full Text Available The Common HOL project aims to facilitate porting source code and proofs between members of the HOL family of theorem provers. At the heart of the project is the Common HOL Platform, which defines a standard HOL theory and API that aims to be compatible with all HOL systems. So far, HOL Light and hol90 have been adapted for conformance, and HOL Zero was originally developed to conform. In this paper we provide motivation for a platform, give an overview of the Common HOL Platform's theory and API components, and show how to adapt legacy systems. We also report on the platform's successful application in the hand-translation of a few thousand lines of source code from HOL Light to HOL Zero.

  18. The Creative Platform

    DEFF Research Database (Denmark)

    Byrge, Christian; Hansen, Søren

    whether you consider thirdgrade teaching, human-resource development, or radical new thinking in product development in a company. The Creative Platform was developed at Aalborg University through a series of research-and-development activities in collaboration with educational institutions and private......This book is about introducing more creativity into general educational courses and cross-disciplinary activities. It is directed toward teachers at all levels in the educational system, but the Creative Platform is a general model, and thus the creative process will fundamentally be the same...... companies. It is a project in which the goal is to make a hands-on approach to a knowledge perspective on enhancing creativity. The underlying ambition of the Creative Platform is to make it easier to promote creativity. At www.uka.aau.dk/The+Creative+Platform, you can find extra materials and instructions...

  19. CAP-D3 Promotes Bacterial Clearance in Human Intestinal Epithelial Cells by Repressing Expression of Amino Acid Transporters

    Science.gov (United States)

    Kemp, Jacqueline R.; Nickerson, Kourtney P.; Deutschman, Emily; Kim, Yeojung; West, Gail; Sadler, Tammy; Stylianou, Eleni; Krokowski, Dawid; Hatzoglou, Maria; de la Motte, Carol; Rubin, Brian P.; Fiocchi, Claudio

    2015-01-01

    BACKGROUND & AIMS Defects in colonic epithelial barrier defenses are associated with ulcerative colitis (UC). The proteins that regulate bacterial clearance in the colonic epithelium have not been completely identified. The chromosome-associated protein D3 (dCAP-D3), regulates responses to bacterial infection. We examined whether CAP-D3 promotes bacterial clearance in human colonic epithelium. METHODS Clearance of Salmonella or adherent-invasive Escherichia coli LF82 was assessed by gentamycin protection assays in HT-29 and Caco-2 cells expressing small hairpin RNAs against CAP-D3. We used immunoblot assays to measure levels of CAP-D3 in colonic epithelial cells from patients with UC and healthy individuals (controls). RNA sequencing identified genes activated by CAP-D3. We analyzed the roles of CAP-D3 target genes in bacterial clearance using gentamycin protection and immunofluorescence assays and studies with pharmacologic inhibitors. RESULTS CAP-D3 expression was reduced in colonic epithelial cells from patients with active UC. Reduced CAP-D3 expression decreased autophagy and impaired intracellular bacterial clearance by HT-29 and Caco-2 colonic epithelial cells. Lower levels of CAP-D3 increased transcription of genes encoding SLC7A5 and SLC3A2, whose products heterodimerize to form an amino acid transporter in HT-29 cells following bacterial infection; levels of SLC7A5–SLC3A2 were increased in tissues from patients with UC, compared with controls. Reduced CAP-D3 in HT-29 cells resulted in earlier recruitment of SLC7A5 to Salmonella-containing vacuoles, increased activity of mTORC1, and increased survival of bacteria. Inhibition of SLC7A5–SLC3A2 or mTORC1 activity rescued the bacterial clearance defects of CAP-D3– deficient cells. CONCLUSIONS CAP-D3 downregulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells. Levels of CAP-D3 protein are reduced in patients with

  20. The use of bottle caps as submerged aerated filter medium.

    Science.gov (United States)

    Damasceno de Oliveira, Laurence; Motlagh, Amir Mohaghegh; Goel, Ramesh; de Souza Missagia, Beatriz; Alves de Abreu Filho, Benício; Lautenschlager, Sandro Rogério

    2014-01-01

    In this study, a submerged aerated filter (SAF) using bottle caps as a support medium was evaluated. The system was fed with effluent from an upflow anaerobic sludge blanket system at ETE 2-South wastewater treatment plant, under different volumetric organic load rates (VOLRs). The population of a particular nitrifying microbial community was assessed by fluorescent in situ hybridization with specific oligonucleotide probes. The system showed an average removal of chemical oxygen demand (COD) equal to 76% for VOLRs between 2.6 and 13.6 kg COD m(-3)_media.day(-1). The process of nitrification in conjunction with the removal of organic matter was observed from applying VOLRs lower than 5.5 kg COD m(-3)_media.day(-1) resulting in 78% conversion of NH4(+)-N. As the applied organic load was reduced, an increase in the nitrifying bacteria population was observed compared with total 4'-6-diamidino-2-phenylindole (DAPI) stained cells. Generally, SAF using bottle caps as a biological aerated filter medium treating wastewater from an anaerobic system showed promising removal of chemical oxygen demand (COD) and conversion of NH4(+)-N.

  1. Should we geoengineer larger ice caps?

    CERN Document Server

    Haqq-Misra, Jacob

    2015-01-01

    The climate of Earth is susceptible to catastrophes that could threaten the longevity of human civilization. Geoengineering to reduce incoming solar radiation has been suggested as a way to mediate the warming effects of contemporary climate change, but a geoengineering program for thousands of years could also be used to enlarge the size of the polar ice caps and create a permanently cooler climate. Such a large ice cap state would make Earth less susceptible to climate threats and could allow human civilization to survive further into the future than otherwise possible. Intentionally extending Earth's glacial coverage will require uninterrupted commitment to this program for millenia but would ultimately reach a cooler equilibrium state where geoengineering is no longer needed. Whether or not this program is ever attempted, this concept illustrates the need to identify preference among potential climate states to ensure the long-term success of civilization.

  2. Status of the AlCap experiment

    CERN Document Server

    Litchfield, R Phillip

    2015-01-01

    The AlCap experiment is a joint project between the COMET and Mu2e collaborations. Both experiments intend to look for the lepton-flavour violating conversion $\\mu + A \\rightarrow e + A$, using tertiary muons from high-power pulsed proton beams. In these experiments the products of ordinary muon capture in the muon stopping target are an important concern, both in terms of hit rates in tracking detectors and radiation damage to equipment. The goal of the AlCap experiment is to provide precision measurements of the products of nuclear capture on Aluminium, which is the favoured target material for both COMET and Mu2e. The results will be used for optimising the design of both conversion experiments, and as input to their simulations. Data was taken in December 2013 and is currently being analysed.

  3. Greening CAP payments: a missed opportunity?

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Alan

    2013-01-15

    At an important point in the current reform of the Common Agricultural Policy (CAP), a new IIEA policy brief by Professor Alan Matthews, one of the EU’s foremost experts on the topic, considers proposals to green direct farm payments. Professor Matthews argues that proposed greening of direct payments – the key innovation in the current round of CAP Reform – look likely to fail. While greening may survive as a concept, the likely outcome of the negotiations between Agriculture Ministers and the European Parliament will deliver little practical environmental benefit. The paper examines the rationale underpinning greening, arguing that it exists to justify the continuation of a large agricultural budget, explores reasons for the apparent failure of the proposals, and reflects on the implications for future efforts to better integrate environmental objectives into EU agriculture policy. This is the first in a series of Environment Nexus policy briefs by leading experts in the fields of agriculture, energy, climate change and water.

  4. National Community Solar Platform

    Energy Technology Data Exchange (ETDEWEB)

    Rupert, Bart [Clean Energy Collective, Louisville, CO (United States)

    2016-06-30

    This project was created to provide a National Community Solar Platform (NCSP) portal known as Community Solar Hub, that is available to any entity or individual who wants to develop community solar. This has been done by providing a comprehensive portal to make CEC’s solutions, and other proven community solar solutions, externally available for everyone to access – making the process easy through proven platforms to protect subscribers, developers and utilities. The successful completion of this project provides these tools via a web platform and integration APIs, a wide spectrum of community solar projects included in the platform, multiple groups of customers (utilities, EPCs, and advocates) using the platform to develop community solar, and open access to anyone interested in community solar. CEC’s Incubator project includes web-based informational resources, integrated systems for project information and billing systems, and engagement with customers and users by community solar experts. The combined effort externalizes much of Clean Energy Collective’s industry-leading expertise, allowing third parties to develop community solar without duplicating expensive start-up efforts. The availability of this platform creates community solar projects that are cheaper to build and cheaper to participate in, furthering the goals of DOE’s SunShot Initiative. Final SF 425 Final SF 428 Final DOE F 2050.11 Final Report Narrative

  5. ALTERNATE REDUCTANT COLD CAP EVALUATION FURNACE PHASE I TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F.; Miller, D.; Zamecnik, J.; Lambert, D.

    2014-04-22

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further evaluation of this flowsheet eliminated the formic acid1, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP): Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the Cold Cap Evaluation Furnace (CEF) cold cap and vapor space data to the benchmark melter flammability models Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: o Define new cold cap reactions and global kinetic parameters for the melter flammability models o Quantify off-gas surging potential of the feed o Characterize off-gas condensate for complete organic and inorganic carbon species Prior to startup, a number of improvements and modifications were made to the CEF, including addition of cameras, vessel support temperature measurement, and a heating

  6. Cytocompatibility and Antibacterial Properties of Capping Materials

    OpenAIRE

    Claudio Poggio; Carla Renata Arciola; Riccardo Beltrami; Annachiara Monaco; Alberto Dagna; Marco Lombardini; Livia Visai

    2014-01-01

    The aim of this study was to evaluate and compare the antimicrobial activity and cytocompatibility of six different pulp-capping materials: Dycal (Dentsply), Calcicur (Voco), Calcimol LC (Voco), TheraCal LC (Bisco), MTA Angelus (Angelus), and Biodentine (Septodont). To evaluate antimicrobial activity, materials were challenged in vitro with Streptococcus mutans, Streptococcus salivarius, and Streptococcus sanguis in the agar disc diffusion test. Cytocompatibility of the assayed materials towa...

  7. Farmer preference for CAPS: Workshop and analysis

    OpenAIRE

    Reed, B.F.

    2012-01-01

    Analytic Hierarchy Process (AHP) is a a multi-criteria, multi-level decision-making method which breaks down complex decisions into a series of simple questions reflecting an optimal goal, objectives, and various options. This provides a structured technique for organizing and analyzing differing preferences for Conservation Agriculture Production Systems (CAPS). This presentation explains AHP and conducts a survey to collect gender-specific preference data for selected conservation agricultu...

  8. Synthetically and quantitatively assessing gas-sealing ability of volcanic cap rocks in the Xujiaweizi Sag of the Songliao Basin%松辽盆地徐家围子断陷火山岩盖层封气能力综合定量评价

    Institute of Scientific and Technical Information of China (English)

    史集建; 吕延防; 付广; 李丽丽

    2011-01-01

    对松辽盆地徐家围子断陷14个火山岩盖层气藏解剖研究表明,徐家围子断陷白垩系营城组一段顶部火山岩盖层具有高声波时差和井径扩容的特征,岩性主要为凝灰岩、火山角砾岩等,厚度为0~80m,是一套良好的局部盖层.在分析火山岩盖层封气能力的影响因素,即火山岩厚度、排替压力、断层垂向封闭性、天然气黏度和气藏压力基础上,建立了火山岩封气能力综合评价方法,并得到天然气储量丰度与其火山岩盖层封气能力综合评价参数a具有正相关关系.结合天然气储量丰度的划分标准,得到徐家围子断陷形成高储量丰度气藏所需要的a值大于或等于0.005m·Pa·s,形成中等储量丰度气藏所需要的a值为00005~0.002m·Pa·s,形成低储量车度气藏所需要的a值为0.002~0.0003m·Pa·s,形成特低储量丰度气藏所需要的a值小于0.0003m·Pa·s.由此得到火山岩盖层封气能力分布特征:封闭高储量丰度气藏的火山岩盖层主要分布在徐家围子断陷东北部地区;封闭中等储量丰度气藏的火山岩盖层全区基本均有分布;封闭低储量丰度气藏的火山岩盖层主要分布在徐家围子断陷中部和南部地区,西北部也有局部分布;封闭特低储量丰度气藏的火山岩盖层在全区零星分布,主要处于火山岩盖层的尖灭线附近.徐家围子断陷天然气的富集在一定程度上受到火山岩盖层封气能力的控制.%The present paper studied 14 gas reservoirs in the Xujiaweizi rift Sag, Songliao Basin thoroughly and the result showed that volcanic rocks in the top of the first member of Yingcheng Formation, composed mainly of tuff and volcanic breccia with a thickness between 0 and 80 cm, were characterized by high interval transit time and enlarged borehole diameter, and locally formed a suite of good cap rocks.Consequently, a method was established for synthetically assessing gas-sealing ability of these

  9. Protein synthesis in geostimulated root caps

    Science.gov (United States)

    Feldman, L. J.

    1982-01-01

    A study is presented of the processes occurring in the root cap of corn which are requisite for the formation of root cap inhibitor and which can be triggered or modulated by both light and gravity. The results of this study indicate the importance of protein synthesis for light-induced gravitropic bending in roots. Root caps in which protein synthesis is prevented are unable to induce downward bending. This suggests that light acts by stimulating proteins which are necessary for the translation of the gravitropic stimulus into a growth response (downward bending). The turnover of protein with time was also examined in order to determine whether light acts by stimulating the synthesis of unique proteins required for downward growth. It is found that auxin in combination with light allows for the translation of the gravitropic stimulus into a growth response at least in part through the modification of protein synthesis. It is concluded that unique proteins are stimulated by light and are involved in promoting the downward growth in roots which are responding to gravity.

  10. Pulp-Capping with Mineral Trioxide Aggregate

    Directory of Open Access Journals (Sweden)

    Peycheva Kalina

    2015-11-01

    Full Text Available There are two considerations for direct pulp capping - accidental mechanical pulp exposure and exposure caused by caries. Mineral trioxide aggregate (MTA was used as pulp-capping material to preserve the vitality of the pulpal tissues. Follow-up examinations revealed that treatment was successful in preserving pulpal vitality and continued development of the tooth. On the basis of available information, it appears that MTA is the material of choice for some clinical applications. Material and methods: Cases 18 - 8 teeth with grey MTA, 10 teeth with white MTA; diagnose: Pulpitis chronica ulcerosa, Electro pulpal test (EOD - 30-35 μA, pre-clinical X-ray - without changes in the structures, follow ups for 4 years. Successful treatments: without clinical symptoms and changes in the X-rays: 5 teeth with grey MTA, 8 teeth with white MTA for period of 4 years. Unsuccessful treatments: Clinical symptoms and sometimes changes in the X-ray: 3 with grey MTA, 2 with white MTA. MTA is an appropriate material for pulp-capping and follow-up examinations revealed that the treatment was successful in preserving pulpal vitality.

  11. The Platformization of the Web: Making Web Data Platform Ready

    NARCIS (Netherlands)

    A. Helmond

    2015-01-01

    In this article, I inquire into Facebook’s development as a platform by situating it within the transformation of social network sites into social media platforms. I explore this shift with a historical perspective on, what I refer to as, platformization, or the rise of the platform as the dominant

  12. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS).

    Science.gov (United States)

    Kuemmerle-Deschner, Jasmin B; Ozen, Seza; Tyrrell, Pascal N; Kone-Paut, Isabelle; Goldbach-Mansky, Raphaela; Lachmann, Helen; Blank, Norbert; Hoffman, Hal M; Weissbarth-Riedel, Elisabeth; Hugle, Boris; Kallinich, Tilmann; Gattorno, Marco; Gul, Ahmet; Ter Haar, Nienke; Oswald, Marlen; Dedeoglu, Fatma; Cantarini, Luca; Benseler, Susanne M

    2016-10-04

    Cryopyrin-associated periodic syndrome (CAPS) is a rare, heterogeneous disease entity associated with NLRP3 gene mutations and increased interleukin-1 (IL-1) secretion. Early diagnosis and rapid initiation of IL-1 inhibition prevent organ damage. The aim of the study was to develop and validate diagnostic criteria for CAPS. An innovative process was followed including interdisciplinary team building, item generation: review of CAPS registries, systematic literature review, expert surveys, consensus conferences for item refinement, item reduction and weighting using 1000Minds decision software. Resulting CAPS criteria were tested in large cohorts of CAPS cases and controls using correspondence analysis. Diagnostic models were explored using sensitivity analyses. The international team included 16 experts. Systematic literature and registry review identified 33 CAPS-typical items; the consensus conferences reduced these to 14. 1000Minds exercises ranked variables based on importance for the diagnosis. Correspondence analysis determined variables consistently associated with the diagnosis of CAPS using 284 cases and 837 controls. Seven variables were significantly associated with CAPS (pCAPS-typical symptoms: urticaria-like rash, cold-triggered episodes, sensorineural hearing loss, musculoskeletal symptoms, chronic aseptic meningitis and skeletal abnormalities. Sensitivity was 81%, specificity 94%. It performed well for all CAPS subtypes and regardless of NLRP3 mutation. The novel approach integrated traditional methods of evidence synthesis with expert consensus, web-based decision tools and innovative statistical methods and may serve as model for other rare diseases. These criteria will enable a rapid diagnosis for children and adults with CAPS.

  13. Transactional Network Platform: Applications

    Energy Technology Data Exchange (ETDEWEB)

    Katipamula, Srinivas; Lutes, Robert G.; Ngo, Hung; Underhill, Ronald M.

    2013-10-31

    In FY13, Pacific Northwest National Laboratory (PNNL) with funding from the Department of Energy’s (DOE’s) Building Technologies Office (BTO) designed, prototyped and tested a transactional network platform to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). Initially, in FY13, the concept demonstrated transactions between packaged rooftop air conditioners and heat pump units (RTUs) and the electric grid using applications or "agents" that reside on the platform, on the equipment, on a local building controller or in the Cloud. The transactional network project is a multi-lab effort with Oakridge National Laboratory (ORNL) and Lawrence Berkeley National Laboratory (LBNL) also contributing to the effort. PNNL coordinated the project and also was responsible for the development of the transactional network (TN) platform and three different applications associated with RTUs. This document describes two applications or "agents" in details, and also summarizes the platform. The TN platform details are described in another companion document.

  14. On the polar cap cascade pair multiplicity of young pulsars

    CERN Document Server

    Timokhin, A N

    2015-01-01

    We study the efficiency of pair production in polar caps of young pulsars under a variety of conditions to estimate the maximum possible multiplicity of pair plasma in pulsar magnetospheres. We develop a semi-analytic model for calculation of cascade multiplicity which allows efficient exploration of the parameter space and corroborate it with direct numerical simulations. Pair creation processes are considered separately from particle acceleration in order to assess different factors affecting cascade efficiency, with acceleration of primary particles described by recent self-consistent non-stationary model of pair cascades. We argue that the most efficient cascades operate in the curvature radiation/synchrotron regime, the maximum multiplicity of pair plasma in pulsar magnetospheres is ~few x 10^5. The multiplicity of pair plasma in magnetospheres of young energetic pulsars weakly depends on the strength of the magnetic field and the radius of curvature of magnetic field lines and has a stronger dependence ...

  15. Review suggests direct pulp capping with MTA more effective than calcium hydroxide.

    Science.gov (United States)

    Rasaratnam, Lakshmi

    2016-09-01

    Data sourcesPubMed, the Cochrane Library, Embase, and the Web of Knowledge.Study selectionRandomised controlled trials (RCTs) or retrospective non-randomised trials (RNTs) of direct pulp capping in patients comparing mineral trioxide aggregate (MTA) with calcium hydroxide (CH) were considered.Data extraction and synthesisTwo reviewers independently abstracted data. Risk of bias for the RCTs was assessed using the Cochrane risk of bias tool and RNTs were assessed according to the methodological index for non-randomised studies. Different study designs were analysed separately.ResultsThirteen studies were included, ten of which were RCTs. Meta-analysis demonstrated a significantly higher success rate for MTA compared with the CH-capped groups. For RCT studies (2 studies, 405 teeth): OR = 2.26; (95% CI, 1.33-3.85; P = .003) and for RNTs (3 studies - 526 teeth): OR = 2.88; (95% CI, 1.86-4.44; P MTA showing significantly less inflammation compared with CH samples (OR = 4.56; 95% CI, 2.65 7.83; P MTA than CH-capped groups (OR = 3.56; 95% CI, 1.89 6.70; P MTA appears to be a suitable replacement of CH used for direct pulp capping.

  16. Geostationary multipurpose platforms

    Science.gov (United States)

    Bekey, I.; Bowman, R. M.

    1981-01-01

    In addition to the advantages generally associated with orbital platforms, such as improved reliability, economies of scale, simple connectivity of elements, reduced tracking demands and the restraint of orbital object population growth, geostationary platforms yield: (1) continuous access by fixed ground antennas for communications services; (2) continuous monitoring of phenomena over chosen regions of the earth's surface; (3) a preferred location for many solar-terrestrial physics experiments. The geostationary platform also offers a low-risk and economical solution to the impending saturation of the orbital arc/frequency spectrum, maximizing the capacity of individual slots and increasing the utility of the entire arc. It also allows the use of many small, simple and inexpensive earth stations through complexity inversion and high power per beam. Block diagram and operational flowcharts are provided.

  17. Identification of platform levels

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik

    2005-01-01

    reduction, ability to launch a wider product portfolio without increasing resources and reduction of complexity within the whole company. To support the multiple product development process, platform based product development has in many companies such as Philips, VW, Ford etc. proven to be a very effective...... because the nature of developing platforms and applications are very different. In single product development reuse is often determined by individual designers, in multiple product development reuse is to a large degree a management issue. It is difficult for a company to switch from single to multiple...... development will be examined. Based on the identification of the above characteristics five platform levels are described. The research presented in this paper is a result of MSc, Ph.D projects at the Technical University of Denmark and consultancy projects within the organisation of Institute of Product...

  18. Universal visualization platform

    Science.gov (United States)

    Gee, Alexander G.; Li, Hongli; Yu, Min; Smrtic, Mary Beth; Cvek, Urska; Goodell, Howie; Gupta, Vivek; Lawrence, Christine; Zhou, Jainping; Chiang, Chih-Hung; Grinstein, Georges G.

    2005-03-01

    Although there are a number of visualization systems to choose from when analyzing data, only a few of these allow for the integration of other visualization and analysis techniques. There are even fewer visualization toolkits and frameworks from which one can develop ones own visualization applications. Even within the research community, scientists either use what they can from the available tools or start from scratch to define a program in which they are able to develop new or modified visualization techniques and analysis algorithms. Presented here is a new general-purpose platform for constructing numerous visualization and analysis applications. The focus of this system is the design and experimentation of new techniques, and where the sharing of and integration with other tools becomes second nature. Moreover, this platform supports multiple large data sets, and the recording and visualizing of user sessions. Here we introduce the Universal Visualization Platform (UVP) as a modern data visualization and analysis system.

  19. Recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap.

    Directory of Open Access Journals (Sweden)

    Yasuhiro Takeuchi

    Full Text Available Homologous recombination is a dominant force in evolution and results in genetic mosaics. To detect evidence of recombination events and assess the biological significance of genetic mosaics, genome sequences for various viral populations of reasonably large size are now available in the GenBank. We studied a multi-functional viral gene, the adeno-associated virus (AAV cap gene, which codes for three capsid proteins, VP1, VP2 and VP3. VP1-3 share a common C-terminal domain corresponding to VP3, which forms the viral core structure, while the VP1 unique N-terminal part contains an enzymatic domain with phospholipase A2 activity. Our recombinant detection program (RecI revealed five novel recombination events, four of which have their cross-over points in the N-terminal, VP1 and VP2 unique region. Comparison of phylogenetic trees for different cap gene regions confirmed discordant phylogenies for the recombinant sequences. Furthermore, differences in the phylogenetic tree structures for the VP1 unique (VP1u region and the rest of cap highlighted the mosaic nature of cap gene in the AAV population: two dominant forms of VP1u sequences were identified and these forms are linked to diverse sequences in the rest of cap gene. This observation together with the finding of frequent recombination in the VP1 and 2 unique regions suggests that this region is a recombination hot spot. Recombination events in this region preserve protein blocks of distinctive functions and contribute to convergence in VP1u and divergence of the rest of cap. Additionally the possible biological significance of two dominant VP1u forms is inferred.

  20. Role of laser irradiation in direct pulp capping procedures: a systematic review and meta-analysis.

    Science.gov (United States)

    Javed, Fawad; Kellesarian, Sergio Varela; Abduljabbar, Tariq; Gholamiazizi, Elham; Feng, Changyong; Aldosary, Khaled; Vohra, Fahim; Romanos, Georgios E

    2017-02-01

    A variety of materials are available to treat exposed dental pulp by direct pulp capping. The healing response of the pulp is crucial to form a dentin bridge and seal off the exposed pulp. Studies have used lasers to stimulate the exposed pulp to form tertiary dentin. The aim of the present systematic review and meta-analysis was to evaluate the evidence on the effects of laser irradiation as an adjunctive therapy to stimulate healing after pulp exposure. A systematic literature search was conducted up to April 2016. A structured search using the keywords "Direct pulp capping," "Lasers," "Calcium hydroxide pulp capping," and "Resin pulp capping" was performed. Initially, 34 potentially relevant articles were identified. After removal of duplicates and screening by title, abstract, and full text when necessary, nine studies were included. Studies were assessed for bias and data were synthetized using a random-effects meta-analysis model. Six studies were clinical, and three were preclinical animal trials; the follow-up period ranged from 2 weeks to 54 months. More than two thirds of the included studies showed that laser therapy used as an adjunct for direct pulp capping was more effective in maintaining pulp vitality than conventional therapy alone. Meta-analysis showed that the success rate in the laser treatment group was significantly higher than the control group (log odds ratio = 1.737; 95 % confidence interval, 1.304-2.171). Lasers treatment of exposed pulps can improve the outcome of direct pulp capping procedures; a number of confounding factors may have influenced the outcomes of the included studies.

  1. Phosphogypsum capping depth affects revegetation and hydrology in Western Canada.

    Science.gov (United States)

    Jackson, Mallory E; Naeth, M Anne; Chanasyk, David S; Nichol, Connie K

    2011-01-01

    Phosphogypsum (PG), a byproduct of phosphate fertilizer manufacturing, is commonly stacked and capped with soil at decommissioning. Shallow (0, 8, 15, and 30 cm) and thick (46 and 91 cm) sandy loam caps on a PG stack near Fort Saskatchewan, Alberta, Canada, were studied in relation to vegetation establishment and hydrologic properties. Plant response was evaluated over two growing seasons for redtop ( L.), slender wheatgrass ( (Link) Malte ex H.F. Lewis), tufted hairgrass ( (L.) P. Beauv.), and sheep fescue ( L.) and for a mix of these grasses with alsike clover ( L.). Water content below the soil-PG interface was monitored with time-domain reflectometry probes, and leachate water quantity and quality at a depth of 30 cm was measured using lysimeters. Vegetation responded positively to all cap depths relative to bare PG, with few significant differences among cap depths. Slender wheatgrass performed best, and tufted hairgrass performed poorly. Soil caps <1 m required by regulation were sufficient for early revegetation. Soil water fluctuated more in shallow than in thick caps, and water content was generally between field capacity and wilting point regardless of cap depth. Water quality was not affected by cap depths ≤30 cm. Leachate volumes at 30 cm from distinct rainfall events were independent of precipitation amount and cap depth. The study period had lower precipitation than normal, yet soil caps were hospitable for plant growth in the first 2 yr of establishment.

  2. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2010-01-01

    The Azure Services Platform is a brand-new cloud-computing technology from Microsoft. It is composed of four core components-Windows Azure, .NET Services, SQL Services, and Live Services-each with a unique role in the functioning of your cloud service. It is the goal of this book to show you how to use these components, both separately and together, to build flawless cloud services. At its heart Windows Azure Platform is a down-to-earth, code-centric book. This book aims to show you precisely how the components are employed and to demonstrate the techniques and best practices you need to know

  3. Windows Azure Platform

    CERN Document Server

    Redkar, Tejaswi

    2011-01-01

    The Windows Azure Platform has rapidly established itself as one of the most sophisticated cloud computing platforms available. With Microsoft working to continually update their product and keep it at the cutting edge, the future looks bright - if you have the skills to harness it. In particular, new features such as remote desktop access, dynamic content caching and secure content delivery using SSL make the latest version of Azure a more powerful solution than ever before. It's widely agreed that cloud computing has produced a paradigm shift in traditional architectural concepts by providin

  4. Quantifying Solar Wind-Polar Cap Interactions

    Science.gov (United States)

    Urban, K. D.; Gerrard, A. J.; Lanzerotti, L. J.; Weatherwax, A. T.; Huang, Y.

    2015-12-01

    It is well known that the solar wind is a major driver of ultra-low frequency [ULF] power at ground locations from low to high latitudes. However, due to the scarcity of deep polar cap magnetometer sites, it is not clear when, where, or if this is true deep inside the polar cap on open field lines where interplanetary magnetic field [IMF] ULF waves could possibly be directly detected. Given recent observations of very large Joule heating estimates from DMSP data, together with the large heating reported by the CHAMP satellite, it is important to understand the degree to which ULF waves in the solar wind can directly cause such heating. Using a time series of lagged correlation sequences ("dynamic correlograms") between GSM Bz ULF power (computed via data obtained from NASA's Advanced Composition Explorer [ACE] ahead of Earth in the solar wind) and the horizontal ULF power (H^2=N^2+E^2) from ground-based magnetometers in Earth's southern polar cap, we investigate the direct penetration of ULF waves from the solar wind into the polar ionosphere during a gamut of space weather conditions at a distributed network of Automated Geophysical Observatories [AGOs] in Antarctica. To infer causation, a predicted lag correlation maximum at each time step is computed by simply dividing the associated distance of ACE from Earth by the concurrent bulk solar wind speed. This technique helps parse out direct penetration of solar wind ULF waves from other sources (e.g., via leakage from closed field line resonances due to the bulk solar wind plasma viscously interacting at dawn/dusk flanks inducing Kelvin-Helmholtz instabilities [KHI] or compressional modes induced by impulses in solar wind dynamic pressure). The identified direct-penetrating ULF waves are related to the DMSP-derived Poynting fluxes by regression analysis, and conclusions are drawn for the importance of the ULF source for the measured heating.

  5. MARK II end cap calorimeter electronics

    Energy Technology Data Exchange (ETDEWEB)

    Jared, R.C.; Haggerty, J.S.; Herrup, D.A.; Kirsten, F.A.; Lee, K.L.; Olson, S.R.; Wood, D.R.

    1985-10-01

    An end cap calorimeter system has been added to the MARK II detector in preparation for its use at the SLAC Linear Collider. The calorimeter uses 8744 rectangular proportional counter tubes. This paper describes the design features of the data acquisition electronics that has been installed on the calorimeter. The design and use of computer-based test stands for the amplification and signal-shaping components is also covered. A portion of the complete system has been tested in a beam at SLAC. In these initial tests, using only the calibration provided by the test stands, a resolution of 18%/..sqrt..E was achieved.

  6. Comparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Jakub Gruszczyk

    Full Text Available A particular class of tyrosine-kinases sharing no structural similarity with eukaryotic tyrosine-kinases has been evidenced in a large array of bacterial species. These bacterial tyrosine-kinases are able to autophosphorylate on a C-terminal tyrosine-rich motif. Their autophosphorylation has been shown to play a crucial role in the biosynthesis or export of capsular polysaccharide. The analysis of the first crystal structure of the staphylococcal tyrosine kinase CapB2 associated with the activating domain of the transmembrane modulator CapA1 had brought conclusive explanation for both the autophosphorylation and activation processes. In order to explain why CapA1 activates CapB2 more efficiently than its cognate transmembrane modulator CapA2, we solved the crystal structure of CapA2B2 and compared it with the previously published structure of CapA1B2. This structural analysis did not provide the expected clues about the activation discrepancy observed between the two modulators. Staphylococcus aureus also encodes for a CapB2 homologue named CapB1 displaying more than 70% sequence similarity and being surprisingly nearly unable to autophosphorylate. We solved the crystal structure of CapA1B1 and carefully compare it with the structure of CapA1B2. The active sites of both proteins are highly conserved and the biochemical characterization of mutant proteins engineered to test the importance of small structural discrepancies identified between the two structures did not explain the inactivity of CapB1. We thus tested if CapB1 could phosphorylate other protein substrates or hydrolyze ATP. However, no activity could be detected in our in vitro assays. Taken together, these data question about the biological role of the homologous protein pairs CapA1/CapB1 and CapA2/CapB2 and we discuss about several possible interpretations.

  7. Bottom Fixed Platform Dynamics Models Assessing Surface Ice Interactions for Transitional Depth Structures in the Great Lakes: FAST8 – IceDyn

    Energy Technology Data Exchange (ETDEWEB)

    Karr, Dale G. [Univ. of Michigan, Ann Arbor, MI (United States); Yu, Bingbin [Principle Power, Inc., Emeryville, CA (United States); Sirnivas, Senu [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-04-01

    base, were compared. Ice models 1 and 6 do not significantly affect the tower fore-aft shear and moment. However, ice model 2 (dynamic analyses), model 3 (random ice loading), and model 4 (multiple ice failure zone loading) show increased effect on the tower fore-aft shear and moment with significant effect from ice model 3.1. In general ice loading creates large reaction forces and moments at the base of the IBGS foundation; the largest occurred in model 1.1 (steady creep ice indentation loading) followed by model 3.1 (random creep ice indentation loading). In general the power production from the ice loading cases had little deviation from the baseline case without ice loading. For ultimate limit state (ULS), ice model 1.1 ice and 3.1 appear to be the ice most critical models to consider at an early stage of design. Ice model 4 is an important tool for assessing structural fatigue.

  8. Macrophage Capping Protein CapG Is a Putative Oncogene Involved in Migration and Invasiveness in Ovarian Carcinoma

    Directory of Open Access Journals (Sweden)

    J. Glaser

    2014-01-01

    Full Text Available The actin binding protein CapG modulates cell motility by interacting with the cytoskeleton. CapG is associated with tumor progression in different nongynecologic tumor entities and overexpression in breast cancer cell lines correlates with a more invasive phenotype in vitro. Here, we report a significant CapG overexpression in 18/47 (38% of ovarian carcinomas (OC analyzed by qRealTime-PCR analyses. Functional analyses in OC cell lines through siRNA mediated CapG knockdown and CapG overexpression showed CapG-dependent cell migration and invasiveness. A single nucleotide polymorphism rs6886 inside the CapG gene was identified, affecting a CapG phosphorylation site and thus potentially modifying CapG function. The minor allele frequency (MAF of SNP rs6886 (c.1004A/G was higher and the homozygous (A/A, His335 genotype was significantly more prevalent in patients with fallopian tube carcinomas (50% as in controls (10%. With OC being one of the most lethal cancer diseases, the detection of novel biomarkers such as CapG could reveal new diagnostic and therapeutic targets. Moreover, in-depth analyses of SNP rs6886 related to FTC and OC will contribute to a better understanding of carcinogenesis and progression of OC.

  9. Games and Platform Decisions

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    is the application of on-line games in order to provide training for decision makers and in order to generate overview over the implications of platform decisions. However, games have to be placed in a context with other methods and we argue that a mixture of games, workshops, and simulations can provide improved...

  10. Sediment Capping and Natural Recovery, Contaminant Transport Fundamentals With Applications to Sediment Caps

    Science.gov (United States)

    2005-09-01

    source concentration through time are often represented as first-order (exponential) decay processes and can be described by the equation t ot eCC λ...meter. This coupled with the relative homo - geneity of many capping materials should in most settings cause the effects asso- ciated with

  11. Incorporating Wind Generation in Cap and Trade Programs

    Energy Technology Data Exchange (ETDEWEB)

    Bluestein, J.; Salerno, E.; Bird, L.; Vimmerstedt, L.

    2006-07-01

    Cap and trade programs are increasingly being used to reduce emissions from electricity generation in the United States. Cap and trade programs primarily target emitting generators, but programs have also included renewable generators, such as wind generators. States cite several reasons why they have considered the policy option of including renewable generators in cap and trade programs: to provide an incentive for lower-emitting generation, to achieve emissions reductions in non-capped pollutants, and to gain local economic benefits associated with renewable energy projects. The U.S. Environmental Protection Agency also notes these rationales for considering this policy alternative, and the National Association of Regulatory Commissioners (NARUC) passed a resolution supporting the inclusion of renewable energy in cap and trade programs. This report explores why states consider this policy option, what participation could mean for wind generators, and how wind generation can most effectively be included in state, federal, and regional cap and trade programs.

  12. Procalcitonin and community-acquired pneumonia (CAP) in children.

    Science.gov (United States)

    Giulia, Bivona; Luisa, Agnello; Concetta, Scazzone; Bruna, Lo Sasso; Chiara, Bellia; Marcello, Ciaccio

    2015-12-07

    The role of procalcitonin (PCT) as a biomarker for sepsis in adults is well documented, while its role in infections affecting neonatal children remains controversial. Among these infections, Community-Acquired pneumonia (CAP) has been studied extensively, because it's the second cause of death in children in developing countries, and one of the most frequent causes of hospitalization in industrialized countries. The PubMed database and the Cochrane Library were used to search for the following keywords: CAP, procalcitonin, and children. Thirteen articles were studied to determine the role of PCT in CAP management, specifically its usefulness for distinguishing pneumococcal infections from viral and unknown infections, for predicting severity and the correct antibiotic treatment. This paper focuses on the studies performed to identify the best inflammatory biomarker for CAP management. Although there is an increase in studies confirming the usefulness of PCT in CAP management in children, further studies are needed to have better understanding of its role for pediatric CAP management.

  13. Clinical outcome of direct pulp capping with MTA or calcium hydroxide: a systematic review and meta-analysis.

    Science.gov (United States)

    Zhu, Chenxi; Ju, Bin; Ni, Rong

    2015-01-01

    Direct pulp capping is one of the most common dental practices in endodontic therapy. This systematic review and meta-analysis aim to determine whether the effect of mineral trioxide aggregate (MTA) and calcium hydroxide for direct pulp capping is different, as measured by the clinical and radiographic analysis. The study list was obtained by searching PubMed, Springer Link, Scopus and Cochrane Database. Only those papers that met the inclusion criteria were analyzed. The results indicated that four studies met the inclusion criteria. Statistically significant difference was found between the success rates of MTA and calcium hydroxide treated teeth that needed direct pulp capping (P=0.002). Clinical assessments of the MTA versus calcium hydroxide for direct pulp capping suggested that MTA was superior to calcium hydroxide in direct pulp capping resulting in a lower failure rate (risk difference 0.1 [95% CI 0.04 to 0.16]). In conclusion, MTA has a higher clinical success rate for direct pulp capping comparing to calcium hydroxide, and might be a suitable replacement for calcium hydroxide.

  14. Arrays of magnetic nanoparticles capped with alkylamines

    Indian Academy of Sciences (India)

    P John Thomas; P Saravanan; G U Kulkarni; C N R Rao

    2002-02-01

    Magnetic metal and metal oxide nanoparticles capped with alkylamines have been synthesized and characterized by transmission electron microscopy, X-ray diffraction, energy dispersive X-ray analysis and magnetization measurements. Core-shell Pd–Ni particles with composition, Pd561Ni3000, (diameter ∼ 3.3 nm) are superparamagnetic at 5 K and organize themselves into two-dimensional crystalline arrays. Similar arrays are obtained with Pd561Ni3000Pd1500 nanoparticles containing an additional Pd shell. Magnetic spinel particles of -Fe2O3, Fe3O4 and CoFe2O4 of average diameters in the 4–6 nm range coated with octylamine are all supermagnetic at room temperature and yield close-packed disordered arrays. Relatively regular arrays are formed by dodecylamine-capped Fe3O4 nanoparticles (∼ 8.6 nm diameter) while well-ordered hexagonal arrays were obtained with octylamine-covered Co3O4 nanoparticles (∼ 4.2 nm diameter).

  15. Comparison of Polar Cap (PC) index calculations.

    Science.gov (United States)

    Stauning, P.

    2012-04-01

    The Polar Cap (PC) index introduced by Troshichev and Andrezen (1985) is derived from polar magnetic variations and is mainly a measure of the intensity of the transpolar ionospheric currents. These currents relate to the polar cap antisunward ionospheric plasma convection driven by the dawn-dusk electric field, which in turn is generated by the interaction of the solar wind with the Earth's magnetosphere. Coefficients to calculate PCN and PCS index values from polar magnetic variations recorded at Thule and Vostok, respectively, have been derived by several different procedures in the past. The first published set of coefficients for Thule was derived by Vennerstrøm, 1991 and is still in use for calculations of PCN index values by DTU Space. Errors in the program used to calculate index values were corrected in 1999 and again in 2001. In 2005 DMI adopted a unified procedure proposed by Troshichev for calculations of the PCN index. Thus there exists 4 different series of PCN index values. Similarly, at AARI three different sets of coefficients have been used to calculate PCS indices in the past. The presentation discusses the principal differences between the various PC index procedures and provides comparisons between index values derived from the same magnetic data sets using the different procedures. Examples from published papers are examined to illustrate the differences.

  16. Selection of satellite constellation framework of CAPS

    Institute of Scientific and Technical Information of China (English)

    HAN YanBen; MA LiHua; QIAO QiYuan; YIN ZhiQiang; AI GuoXiang

    2009-01-01

    Based on the idea of transmitting the satellite navigation and positioning system,taking the distribution and variation of the Position Dilution of Precision factor (PDOP),which is closely related with the precision of navigation and positioning,within the China area as the primary criterion,we analyze and discuss the tentative plan of constellation configuration consisting of geosynchronous orbit (GEO) communication satellites and inclined geosynchronous orbit (IGSO) satellites for the transmitting Chinese Area Positioning System (CAPS).We emphatically consider the effect on the PDOP by the three major orbit parameters including the inclination,eccentricity and right ascension of the ascending node (RAAN) of IGSO satellites,to research the strategies of the constellation configuration of CAPS through software emulation.Various constellation configurations are analyzed and compared and the results show that the constellation configuration,consisting of three IGSO communication satellites in three orbits with the same inclination as 50°,the difference in RAAN as 120°and the same "8" shaped ground track centered near 115°E and four or five GEO communication satellites within 60°E to 150°E,can satisfy the requirement that Chinese domain is availably covered end the navigation and positioning with high precision could be obtained.Three relatively excellent constellation configurations are initially suggested and some concerned issues are discussed in this work.

  17. Selection of satellite constellation framework of CAPS

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Based on the idea of transmitting the satellite navigation and positioning system, taking the distribution and variation of the Position Dilution of Precision factor (PDOP), which is closely related with the precision of navigation and positioning, within the China area as the primary criterion, we analyze and discuss the tentative plan of constellation configuration consisting of geosynchronous orbit (GEO) communication satellites and inclined geosynchronous orbit (IGSO) satellites for the transmitting Chinese Area Positioning System (CAPS). We emphatically consider the effect on the PDOP by the three major orbit parameters including the inclination, eccentricity and right ascension of the ascend- ing node (RAAN) of IGSO satellites, to research the strategies of the constellation configuration of CAPS through software emulation. Various constellation configurations are analyzed and compared and the results show that the constellation configuration, consisting of three IGSO communication satellites in three orbits with the same inclination as 50°, the difference in RAAN as 120° and the same "8" shaped ground track centered near 115°E and four or five GEO communication satellites within 60°E to 150°E, can satisfy the requirement that Chinese domain is availably covered and the navigation and positioning with high precision could be obtained. Three relatively excellent constellation configurations are initially suggested and some concerned issues are discussed in this work.

  18. Magnetically capped rolled-up nanomembranes.

    Science.gov (United States)

    Streubel, Robert; Thurmer, Dominic J; Makarov, Denys; Kronast, Florian; Kosub, Tobias; Kravchuk, Volodymyr; Sheka, Denis D; Gaididei, Yuri; Schäfer, Rudolf; Schmidt, Oliver G

    2012-08-01

    Modifying the curvature in magnetic nanostructures is a novel and elegant way toward tailoring physical phenomena at the nanoscale, allowing one to overcome limitations apparent in planar counterparts. Here, we address curvature-driven changes of static magnetic properties in cylindrically curved magnetic segments with different radii of curvature. The curved architectures are prepared by capping nonmagnetic micrometer- and nanometer-sized rolled-up membranes with a soft-magnetic 20 nm thick permalloy (Ni(80)Fe(20)) film. A quantitative comparison between the magnetization reversal processes in caps with different diameters is given. The phase diagrams of magnetic equilibrium domain patterns (diameter versus length) are generated. For this, joint experimental, including X-ray magnetic circular dichroism photoelectron emission microscopy (XMCD-PEEM), and theoretical studies are carried out. The anisotropic magnetostatic interaction in cylindrically curved architectures originating from the thickness gradient reduces substantially the magnetostatic interaction between closely packed curved nanowires. This feature is beneficial for racetrack memory devices, since a much higher areal density might be achieved than possible with planar counterparts.

  19. MFTF-. cap alpha. + T progress report

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, W.D. (ed.)

    1985-04-01

    Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; they will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.

  20. Lowering the YE+1 end-cap for CMS

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    On 9 January 2007, the massive YE+1 end-cap was lowered into the CMS cavern. This is a very precise process as the crane must lower the end-cap through minimal clearance without tilt or sway. Once in the cavern, the end-cap is then positioned over the end of the barrel to detect particles produced in collisions that travel close to the axis of the beams.

  1. 关于中医药临床研究伦理审查平台建设评估的思考%Enlightenment and Thinking on Platform Construction Assessment of Ethics Review of Clinical Trail of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    凌丽; 吕祥; 夏英; 朱凌云

    2013-01-01

    By assessment of platform construction assessment of ethics review of Traditional Chinese Medicine (TCM) research,the current problems in construction and development of hospital ethics committee were disclosed,including:lack of independency of ethics committee,lack systematical ethics training for researchers,the deficiency of unified standards in multi-center review,less supervison in subsequent research and the lack of management regulation of quality control and interest conflict.Measures include regulating medical ethics training,setting up a joint ethics committee,formulating local standards,clarificating the management principles of quality control and interest conflict and exploring recognition of ethics committee were proposed.%通过中医药临床研究伦理审查平台建设评估,发现目前医院伦理委员会在建设和发展中存在以下问题:工作缺乏较高的独立性、缺乏针对研究者的系统化伦理培训、多中心审查缺乏统一标准、临床研究后续监管力度不够、缺乏质量管理和利益冲突管理机制等.提出了规范医学伦理学培训、建立联合伦理委员会、制定地方标准、明确质量管理原则和利益冲突防范原则、探索实行伦理委员会认证等对策.

  2. Mobile Platforms and Development Environments

    CERN Document Server

    Helal, Sumi; Li, Wengdong

    2012-01-01

    Mobile platform development has lately become a technological war zone with extremely dynamic and fluid movement, especially in the smart phone and tablet market space. This Synthesis lecture is a guide to the latest developments of the key mobile platforms that are shaping the mobile platform industry. The book covers the three currently dominant native platforms -- iOS, Android and Windows Phone -- along with the device-agnostic HTML5 mobile web platform. The lecture also covers location-based services (LBS) which can be considered as a platform in its own right. The lecture utilizes a sampl

  3. Vertical Wave Impacts on Offshore Wind Turbine Inspection Platforms

    DEFF Research Database (Denmark)

    Bredmose, Henrik; Jacobsen, Niels Gjøl

    2011-01-01

    on a horizontal inspection platform is computed for five different platform levels. The computational results show details of monopile impact such as slamming pressures from the overturning wave front and the formation of run-up flow. The results show that vertical platform impacts can occur at 20 m water depth....... The dependence of the vertical platform load to the platform level is discussed. Attention is given to the significant downward force that occur after the upward force associated with the vertical impact. The effect of the numerical resolution on the results is assessed. The position of wave overturning is found...... to be influenced by the grid resolution. For the lowest platform levels, the vertical impact is found to contribute to the peak values of in-line force and overturning moment....

  4. Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP – Results from the German competence network CAPNETZ

    Directory of Open Access Journals (Sweden)

    von Baum Heike

    2009-07-01

    Full Text Available Abstract Background Aim of this study was to evaluate the correlation of inflammatory markers procalcitonin (PCT, C-reactive protein (CRP and leukocyte count (WBC with microbiological etiology of CAP. Methods We enrolled 1337 patients (62 ± 18 y, 45% f with proven CAP. Extensive microbiological workup was performed. In all patients PCT, CRP, WBC and CRB-65 score were determined. Patients were classified according to microbial diagnosis and CRB-65 score. Results In patients with typical bacterial CAP, levels of PCT, CRP and WBC were significantly higher compared to CAP of atypical or viral etiology. There were no significant differences in PCT, CRP and WBC in patients with atypical or viral etiology of CAP. In contrast to CRP and WBC, PCT markedly increased with severity of CAP as measured by CRB-65 score (p 1, AUC for PCT was 0.69 (95% CI 0.66 to 0.71, which was higher compared to CRP and WBC (p Conclusion PCT, CRP and WBC are highest in typical bacterial etiology in CAP but do not allow individual prediction of etiology. In contrast to CRP and WBC, PCT is useful in severity assessment of CAP.

  5. Design and Performance of Capping Layers for EUV Multilayer Mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Bajt, S; Chapman, H N; Nuygen, N; Alameda, J; Robinson, J C; Malinowski, M; Gullikson, E; Aquila, A; Tarrio, C; Grantham, S

    2003-03-10

    The reflectance stability of multilayer coatings for extreme ultraviolet lithography (EUVL) in a commercial tool environment is of uttermost importance to ensure continuous exposures with minimum maintenance cost. We have made substantial progress in designing the protective capping layer coatings, understanding their performance and estimating their lifetimes based on accelerated electron beam and EUV exposure studies. Our current capping layer coatings have about 40 times longer lifetimes than Si-capped multilayer optics. Nevertheless, the lifetime of current Ru-capped multilayers is too short to satisfy commercial tool requirements and further improvements are essential.

  6. Effect of swim cap model on passive drag.

    Science.gov (United States)

    Gatta, Giorgio; Zamparo, Paola; Cortesi, Matteo

    2013-10-01

    Hydrodynamics plays an important role in swimming because even small decreases in a swimmer's drag can lead to performance improvements. During the gliding phases of a race, the head of a swimmer is an important point of impact with the fluid, and the swim cap, even if it covers only a small portion of the swimmer's body, can have an influence on drag. The purpose of this study was to investigate the effects on passive drag (Dp) of wearing 3 different types of swim caps (LSC: a lycra cap; CSC: a silicone cap; HSC: a silicone helmet cap without seams). Sixteen swimmers were tested at 3 velocities (1.5, 1.7, 1.9 m·s), and the Dp measurements were repeated at each condition 5 times. A statistical analysis revealed significant differences in drag (p swim cap is the most rigid, the most adherent to the swimmer's head, and does not allow the formation of wrinkles compared with the other 2 investigated swim caps. Therefore, the following conclusions can be made: (a) swimmers should take care when selecting their swim cap if they want to improve the fluid dynamics at the "leading edge" of their body and (b) because Dp is affected by the swim cap model, care should be taken when comparing data from different studies, especially at faster investigated speeds.

  7. Influenza A virus preferentially snatches noncoding RNA caps

    OpenAIRE

    2015-01-01

    Influenza A virus (IAV) lacks the enzyme for adding 5′ caps to its RNAs and snatches the 5′ ends of host capped RNAs to prime transcription. Neither the preference of the host RNA sequences snatched nor the effect of cap-snatching on host processes is completely defined. Previous studies of influenza cap-snatching used poly(A)-selected RNAs from infected cells or relied on annotated host genes to define the snatched host RNAs, and thus lack details on many noncoding host RNAs including snRNAs...

  8. Analyses of Current And Wave Forces on Velocity Caps

    DEFF Research Database (Denmark)

    Christensen, Erik Damgaard; Buhrkall, Jeppe; Eskesen, Mark C. D.;

    2015-01-01

    Velocity caps are often used in connection with for instance offshore intake sea water for the use of for cooling water for power plants or as a source for desalinization plants. The intakes can also be used for river intakes. The velocity cap is placed on top of a vertical pipe. The vertical pipe......) this paper investigates the current and wave forces on the velocity cap and the vertical cylinder. The Morison’s force model was used in the analyses of the extracted force time series in from the CFD model. Further the distribution of the inlet velocities around the velocity cap was also analyzed in detail...

  9. Study on Alignment Technology of CAP1400 Reactor Internals%CAP1400堆内构件对中检测技术研究

    Institute of Scientific and Technical Information of China (English)

    舒华安; 童庆军; 王盛; 郝磊; 郭健

    2016-01-01

    对中检测是CAP1400堆内构件制造装配的关键检测技术,针对传统光学对中方法的检测结果易受环境和人眼观测误差影响,且作业时间受限等缺点,开发了激光垂准—CCD光靶数据采集处理的新型对中检测方法。通过专用试验平台进行对中比对试验,结果表明该方法测量精度高,成功避免了传统方法的缺点,为堆内构件制造及核电站现场安装提供了新的对中检测方法。%The alignment measurement is the key technology of CAP1400 reactor interal manufacturing and assembly. Traditional method using micrometer collimating telescope has high requirements on the operating environment, operation time. The system of Laser Vertical-CCD optical target data acquisition and processing is developed. The comparison tests made through the special test platform show that the method has high accuracy of measurement. The disadvantages of the traditional optical measurement is avoided. A new method for manufacturing and installation of reactor internal is gained.

  10. Microbial diversity on Icelandic glaciers and ice caps

    Directory of Open Access Journals (Sweden)

    Stefanie eLutz

    2015-04-01

    Full Text Available Algae are important primary colonizers of snow and glacial ice, but hitherto little is known about their ecology on Iceland’s glaciers and ice caps. Due do the close proximity of active volcanoes delivering large amounts of ash and dust, they are special ecosystems. This study provides the first investigation of the presence and diversity of microbial communities on all major Icelandic glaciers and ice caps over a three year period. Using high-throughput sequencing of the small subunit ribosomal RNA genes (16S and 18S, we assessed the snow community structure and complemented these analyses with a comprehensive suite of physical-, geo- and biochemical characterizations of the aqueous and solid components contained in snow and ice samples. Our data reveal that a limited number of snow algal taxa (Chloromonas polyptera, Raphidonema sempervirens and two uncultured Chlamydomonadaceae support a rich community comprising of other micro-eukaryotes, bacteria and archaea. Proteobacteria and Bacteroidetes were the dominant bacterial phyla. Archaea were also detected in sites where snow algae dominated and they mainly belong to the Nitrososphaerales, which are known as important ammonia oxidizers. Multivariate analyses indicated no relationships between nutrient data and microbial community structure. However, the aqueous geochemical simulations suggest that the microbial communities were not nutrient limited because of the equilibrium of snow with the nutrient-rich and fast dissolving volcanic ash. Increasing algal secondary carotenoid contents in the last stages of the melt seasons have previously been associated with a decrease in surface albedo, which in turn could potentially have an impact on the melt rates of Icelandic glaciers.

  11. Sublimation and transport of water from the north residual polar cap on Mars

    Science.gov (United States)

    Haberle, Robert M.; Jakosky, Bruce M.

    1990-01-01

    The possible role of the north residual cap in the current Martian water cycle was examined using models to assess the ability of the cap to supply water to the atmosphere and the ability of the atmospheric circulation to transport it out of the polar regions to low northern latitudes. Results indicate that rather extreme circumstances would be required for the cap to provide all of the observed increase in atmospheric water, such as a combination of high surface winds, low cap emissivities, or substantial evaporation from dark material. But even if these conditions could be met, the high-latitude circulation is too localized in scale to move much water vapor out of the polar environment. Both the present calculations and the data from the Viking's Mars Atmospheric Water Detection Experiment show that about two thirds of the water appearing in the Martian northern hemisphere during summer must be supplied by other sources. It is suggested that the additional source is water desorbing from the nonpolar regolith.

  12. A quantitative analysis of stem cell homeostasis in the Arabidopsis columella root cap.

    Science.gov (United States)

    Hong, Jing Han; Chu, Huangwei; Zhang, Chen; Ghosh, Dipanjana; Gong, Ximing; Xu, Jian

    2015-01-01

    The Lugol's staining method has been widely used to detect changes in the maintenance of stem cell fate in the columella root cap of Arabidopsis roots since the late 1990s. However, various limitations of this method demand for additional or complementary new approaches. For instance, it is unable to reveal the division rate of columella root cap stem cells. Here we report that, by labeling dividing stem cells with 5-ethynyl-2'-deoxyuridine (EdU), the number and distribution of their labeled progeny can be studied so that the division rate of stem cells can be measured quantitatively and in addition, that the progression of stem cell progeny differentiation can be assessed in combination with Lugol's staining. EdU staining takes few hours and visualization of the stain characteristics of columella root cap can be performed easily under confocal microscopes. This simple technology, when used together with Lugol's staining, provides a novel quantitative method to study the dynamics of stem cell behavior that govern homeostasis in the Arabidopsis columella root cap.

  13. A Quantitative Analysis of Stem Cell Homeostasis in the Arabidopsis Columella Root Cap

    Directory of Open Access Journals (Sweden)

    Jing Han eHong

    2015-03-01

    Full Text Available The Lugol’s staining method has been widely used to detect changes in the maintenance of stem cell fate in the columella root cap of Arabidopsis roots since the late ‘90s. However, various limitations of this method demand for additional or complementary new approaches. For instance, it is unable to reveal the division rate of columella root cap stem cells. Here we report that, by labelling dividing stem cells with 5-ethynyl-2´-deoxyuridine (EdU, the number and distribution of their labeled progeny can be studied so that the division rate of stem cells can be measured quantitatively and in addition, that the progression of stem cell progeny differentiation can be assessed in combination with Lugol’s staining. EdU staining takes few hours and visualization of the stain characteristics of columella root cap can be performed easily under confocal microscopes. This simple technology, when used together with Lugol’s staining, provides a novel quantitative method to study the dynamics of stem cell behaviour that govern homeostasis in the Arabidopsis columella root cap.

  14. Present and Future Surface Mass Budget of Small Arctic Ice Caps in a High Resolution Regional Climate Model

    Science.gov (United States)

    Mottram, Ruth; Langen, Peter; Koldtoft, Iben; Midefelt, Linnea; Hesselbjerg Christensen, Jens

    2016-04-01

    Globally, small ice caps and glaciers make a substantial contribution to sea level rise; this is also true in the Arctic. Around Greenland small ice caps are surprisingly important to the total mass balance from the island as their marginal coastal position means they receive a large amount of precipitation and also experience high surface melt rates. Since small ice caps and glaciers have had a disproportionate number of long-term monitoring and observational schemes in the Arctic, likely due to their relative accessibility, they can also be a valuable source of data. However, in climate models the surface mass balance contributions are often not distinguished from the main ice sheet and the presence of high relief topography is difficult to capture in coarse resolution climate models. At the same time, the diminutive size of marginal ice masses in comparison to the ice sheet makes modelling their ice dynamics difficult. Using observational data from the Devon Ice Cap in Arctic Canada and the Renland Ice Cap in Eastern Greenland, we assess the success of a very high resolution (~5km) regional climate model, HIRHAM5 in capturing the surface mass balance (SMB) of these small ice caps. The model is forced with ERA-Interim and we compare observed mean SMB and the interannual variability to assess model performance. The steep gradient in topography around Renland is challenging for climate models and additional statistical corrections are required to fit the calculated surface mass balance to the high relief topography. Results from a modelling experiment at Renland Ice Cap shows that this technique produces a better fit between modelled and observed surface topography. We apply this statistical relationship to modelled SMB on the Devon Ice Cap and use the long time series of observations from this glacier to evaluate the model and the smoothed SMB. Measured SMB values from a number of other small ice caps including Mittivakkat and A.P. Olsen ice cap are also compared

  15. Upgrading platform using alkali metals

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, John Howard

    2017-01-17

    A method for removing sulfur, nitrogen or metals from an oil feedstock. The method involves reacting the oil feedstock with an alkali metal and a radical capping substance. The alkali metal reacts with the metal, sulfur or nitrogen content to form one or more inorganic products and the radical capping substance reacts with the carbon and hydrogen content to form a hydrocarbon phase. The inorganic products may then be separated out from the hydrocarbon phase.

  16. Upgrading platform using alkali metals

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, John Howard

    2014-09-09

    A process for removing sulfur, nitrogen or metals from an oil feedstock (such as heavy oil, bitumen, shale oil, etc.) The method involves reacting the oil feedstock with an alkali metal and a radical capping substance. The alkali metal reacts with the metal, sulfur or nitrogen content to form one or more inorganic products and the radical capping substance reacts with the carbon and hydrogen content to form a hydrocarbon phase. The inorganic products may then be separated out from the hydrocarbon phase.

  17. Common tester platform concept.

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, Michael James

    2008-05-01

    This report summarizes the results of a case study on the doctrine of a common tester platform, a concept of a standardized platform that can be applicable across the broad spectrum of testing requirements throughout the various stages of a weapons program, as well as across the various weapons programs. The common tester concept strives to define an affordable, next-generation design that will meet testing requirements with the flexibility to grow and expand; supporting the initial development stages of a weapons program through to the final production and surveillance stages. This report discusses a concept investing key leveraging technologies and operational concepts combined with prototype tester-development experiences and practical lessons learned gleaned from past weapons programs.

  18. OGC Collaborative Platform undercover

    Science.gov (United States)

    Buehler, G.; Arctur, D. K.; Bermudez, L. E.

    2012-12-01

    The mission of the Open Geospatial Consortium (OGC) is to serve as a global forum for the collaboration of developers and users of spatial data products and services, and to advance the development of international standards for geospatial interoperability. The OGC coordinates with over 400 institutions in the development of geospatial standards. OGC has a dedicated staff supported by a Collaborative Web Platform to enable sophisticated and successful coordination among its members. Since its origins in the early 1990s, the OGC Collaborative Web Platform has evolved organically to be the collaboration hub for standards development in the exchange of geospatial and related types of information, among a global network of thousands of technical, scientific and management professionals spanning numerous disparate application domains. This presentation describes the structure of this collaboration hub, the relationships enabled (both among and beyond OGC members), and how this network fits in a broader ecosystem of technology development and information standards organizations.

  19. Available: motorised platform

    CERN Multimedia

    The COMPASS collaboration

    2014-01-01

    The COMPASS collaboration would like to offer to a new owner the following useful and fully operational piece of equipment, which is due to be replaced with better adapted equipment.   Please contact Erwin Bielert (erwin.bielert@cern.ch or 160539) for further information.  Motorized platform (FOR FREE):   Fabricated by ACL (Alfredo Cardoso & Cia Ltd) in Portugal. The model number is MeXs 5-­‐30.  Specifications: 5 m wide, 1 m deep, adjustable height (1.5 m if folded). Maximum working floor height: 4 m. conforms to CERN regulations, number LV158. Type LD500, capacity 500 kg and weight 2000 kg.  If no interested party is found before December 2014, the platform will be thrown away.

  20. Aging Assessment and Reliability Aware Computing Platforms

    NARCIS (Netherlands)

    Wang, Y.

    2013-01-01

    Aggressive CMOS technology feature size scaling has been going on for the past decades, while the supply voltage is not proportionally scaled. Due to the increasing power density and electric field in the gate dielectric, the accelerating factors of failure mechanisms in nanoscale Integrated Circui

  1. Video analysis platform

    OpenAIRE

    FLORES, Pablo; Arias, Pablo; Lecumberry, Federico; Pardo, Álvaro

    2006-01-01

    In this article we present the Video Analysis Platform (VAP) which is an open source software framework for video analysis, processing and description. The main goals of VAP are: to provide a multiplatform system which allows the easy implementation of video algorithms, provide structures and algorithms for the segmentation of video data in its different levels of abstraction: shots, frames, objects, regions, etc, permit the generation and comparison of MPEG7-like descriptors, and develop tes...

  2. HPC - Platforms Penta Chart

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo, Angelina Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-08

    Strategy, Planning, Acquiring- very large scale computing platforms come and go and planning for immensely scalable machines often precedes actual procurement by 3 years. Procurement can be another year or more. Integration- After Acquisition, machines must be integrated into the computing environments at LANL. Connection to scalable storage via large scale storage networking, assuring correct and secure operations. Management and Utilization – Ongoing operations, maintenance, and trouble shooting of the hardware and systems software at massive scale is required.

  3. Cloud Robotics Platforms

    Directory of Open Access Journals (Sweden)

    Busra Koken

    2015-01-01

    Full Text Available Cloud robotics is a rapidly evolving field that allows robots to offload computation-intensive and storage-intensive jobs into the cloud. Robots are limited in terms of computational capacity, memory and storage. Cloud provides unlimited computation power, memory, storage and especially collaboration opportunity. Cloud-enabled robots are divided into two categories as standalone and networked robots. This article surveys cloud robotic platforms, standalone and networked robotic works such as grasping, simultaneous localization and mapping (SLAM and monitoring.

  4. The Prodiguer Messaging Platform

    Science.gov (United States)

    Denvil, S.; Greenslade, M. A.; Carenton, N.; Levavasseur, G.; Raciazek, J.

    2015-12-01

    CONVERGENCE is a French multi-partner national project designed to gather HPC and informatics expertise to innovate in the context of running French global climate models with differing grids and at differing resolutions. Efficient and reliable execution of these models and the management and dissemination of model output are some of the complexities that CONVERGENCE aims to resolve.At any one moment in time, researchers affiliated with the Institut Pierre Simon Laplace (IPSL) climate modeling group, are running hundreds of global climate simulations. These simulations execute upon a heterogeneous set of French High Performance Computing (HPC) environments. The IPSL's simulation execution runtime libIGCM (library for IPSL Global Climate Modeling group) has recently been enhanced so as to support hitherto impossible realtime use cases such as simulation monitoring, data publication, metrics collection, simulation control, visualizations … etc. At the core of this enhancement is Prodiguer: an AMQP (Advanced Message Queue Protocol) based event driven asynchronous distributed messaging platform. libIGCM now dispatches copious amounts of information, in the form of messages, to the platform for remote processing by Prodiguer software agents at IPSL servers in Paris. Such processing takes several forms: Persisting message content to database(s); Launching rollback jobs upon simulation failure; Notifying downstream applications; Automation of visualization pipelines; We will describe and/or demonstrate the platform's: Technical implementation; Inherent ease of scalability; Inherent adaptiveness in respect to supervising simulations; Web portal receiving simulation notifications in realtime.

  5. "Platform switching": Serendipity

    Directory of Open Access Journals (Sweden)

    N Kalavathy

    2014-01-01

    Full Text Available Implant dentistry is the latest developing field in terms of clinical techniques, research, material science and oral rehabilitation. Extensive work is being done to improve the designing of implants in order to achieve better esthetics and function. The main drawback with respect to implant restoration is achieving good osseointegration along with satisfactory stress distribution, which in turn will improve the prognosis of implant prosthesis by reducing the crestal bone loss. Many concepts have been developed with reference to surface coating of implants, surgical techniques for implant placement, immediate and delayed loading, platform switching concept, etc. This article has made an attempt to review the concept of platform switching was in fact revealed accidentally due to the nonavailability of the abutment appropriate to the size of the implant placed. A few aspect of platform switching, an upcoming idea to reduce crestal bone loss have been covered. The various methods used for locating and preparing the data were done through textbooks, Google search and related articles.

  6. "Platform switching": serendipity.

    Science.gov (United States)

    Kalavathy, N; Sridevi, J; Gehlot, Roshni; Kumar, Santosh

    2014-01-01

    Implant dentistry is the latest developing field in terms of clinical techniques, research, material science and oral rehabilitation. Extensive work is being done to improve the designing of implants in order to achieve better esthetics and function. The main drawback with respect to implant restoration is achieving good osseointegration along with satisfactory stress distribution, which in turn will improve the prognosis of implant prosthesis by reducing the crestal bone loss. Many concepts have been developed with reference to surface coating of implants, surgical techniques for implant placement, immediate and delayed loading, platform switching concept, etc. This article has made an attempt to review the concept of platform switching was in fact revealed accidentally due to the nonavailability of the abutment appropriate to the size of the implant placed. A few aspect of platform switching, an upcoming idea to reduce crestal bone loss have been covered. The various methods used for locating and preparing the data were done through textbooks, Google search and related articles.

  7. Glaciers and ice caps outside Greenland

    Science.gov (United States)

    Sharp, Marin; Wolken, G.; Burgess, D.; Cogley, J.G.; Copland, L.; Thomson, L.; Arendt, A.; Wouters, B.; Kohler, J.; Andreassen, L.M.; O'Neel, Shad; Pelto, M.

    2015-01-01

    Mountain glaciers and ice caps cover an area of over 400 000 km2 in the Arctic, and are a major influence on global sea level (Gardner et al. 2011, 2013; Jacob et al. 2012). They gain mass by snow accumulation and lose mass by meltwater runoff. Where they terminate in water (ocean or lake), they also lose mass by iceberg calving. The climatic mass balance (Bclim, the difference between annual snow accumulation and annual meltwater runoff) is a widely used index of how glaciers respond to climate variability and change. The total mass balance (ΔM) is defined as the difference between annual snow accumulation and annual mass losses (by iceberg calving plus runoff).

  8. Cytocompatibility and Antibacterial Properties of Capping Materials

    Science.gov (United States)

    Arciola, Carla Renata; Monaco, Annachiara; Lombardini, Marco

    2014-01-01

    The aim of this study was to evaluate and compare the antimicrobial activity and cytocompatibility of six different pulp-capping materials: Dycal (Dentsply), Calcicur (Voco), Calcimol LC (Voco), TheraCal LC (Bisco), MTA Angelus (Angelus), and Biodentine (Septodont). To evaluate antimicrobial activity, materials were challenged in vitro with Streptococcus mutans, Streptococcus salivarius, and Streptococcus sanguis in the agar disc diffusion test. Cytocompatibility of the assayed materials towards rat MDPC-23 cells was evaluated at different times by both MTT and apoptosis assays. Results significantly differed among the different materials tested. Both bacterial growth inhibition halos and cytocompatibility performances were significantly different among materials with different composition. MTA-based products showed lower cytotoxicity and valuable antibacterial activity, different from calcium hydroxide-based materials, which exhibited not only higher antibacterial activity but also higher cytotoxicity. PMID:24959601

  9. Carpentier, la otra novela (cap. IV

    Directory of Open Access Journals (Sweden)

    Urbano Martínez Carmenate

    2014-06-01

    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  10. Carpentier, la otra novela (cap. IV

    Directory of Open Access Journals (Sweden)

    Urbano Martínez Carmenate

    2014-07-01

    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  11. Cytocompatibility and Antibacterial Properties of Capping Materials

    Directory of Open Access Journals (Sweden)

    Claudio Poggio

    2014-01-01

    Full Text Available The aim of this study was to evaluate and compare the antimicrobial activity and cytocompatibility of six different pulp-capping materials: Dycal (Dentsply, Calcicur (Voco, Calcimol LC (Voco, TheraCal LC (Bisco, MTA Angelus (Angelus, and Biodentine (Septodont. To evaluate antimicrobial activity, materials were challenged in vitro with Streptococcus mutans, Streptococcus salivarius, and Streptococcus sanguis in the agar disc diffusion test. Cytocompatibility of the assayed materials towards rat MDPC-23 cells was evaluated at different times by both MTT and apoptosis assays. Results significantly differed among the different materials tested. Both bacterial growth inhibition halos and cytocompatibility performances were significantly different among materials with different composition. MTA-based products showed lower cytotoxicity and valuable antibacterial activity, different from calcium hydroxide-based materials, which exhibited not only higher antibacterial activity but also higher cytotoxicity.

  12. Platform computing powers enterprise grid

    CERN Multimedia

    2002-01-01

    Platform Computing, today announced that the Stanford Linear Accelerator Center is using Platform LSF 5, to carry out groundbreaking research into the origins of the universe. Platform LSF 5 will deliver the mammoth computing power that SLAC's Linear Accelerator needs to process the data associated with intense high-energy physics research (1 page).

  13. Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release

    CERN Document Server

    Datz, Stefan; Gattner, Michael; Weiss, Veronika; Brunner, Korbinian; Bretzler, Johanna; von Schirnding, Constantin; Spada, Fabio; Engelke, Hanna; Vrabel, Milan; Bräuchle, Christoph; Carell, Thomas; Bein, Thomas

    2015-01-01

    Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica nanoparticles (MSNs) that is directly combined with a targeting ligand via bio-orthogonal click chemistry. The capping system is based on the pH-responsive binding of an aryl-sulfonamide-functionalized MSN and the enzyme carbonic anhydrase (CA). An unnatural amino acid (UAA) containing a norbornene moiety was genetically incorporated into CA. This UAA allowed for the site-specific bio-orthogonal attachment of even very sensitive targeting ligands such as folic acid and anandamide. This leads to specific receptor-mediated cell and stem cell uptake. We demonstrate the successful delivery and release of the chemotherapeutic agent Actinomycin D to KB cells. This novel nanocarrier concept provides a promising platform for the development of precisely controllable and highly modular theranos...

  14. Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery.

    Science.gov (United States)

    Chen, Ganchao; Xie, Yusheng; Peltier, Raoul; Lei, Haipeng; Wang, Ping; Chen, Jun; Hu, Yi; Wang, Feng; Yao, Xi; Sun, Hongyan

    2016-05-11

    A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) with functional peptide-coated gold nanoparticles (GNPs). MSNs are first functionalized with acid-labile α-amide-β-carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo-lysine-containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to αvβ3 integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides.

  15. Authentic Assessment in California.

    Science.gov (United States)

    Educational Leadership, 1989

    1989-01-01

    Describes the teacher-developed California Assessment Program (CAP) writing measure, designed to support California's reform curriculum and based on matrix sampling techniques. This program will be supplemented by literature and mathematics assessments. The greatest challenge is designing an assessment to match the state's new history and social…

  16. Polar cap index as a proxy for hemispheric Joule heating

    DEFF Research Database (Denmark)

    Chun, F.K.; Knipp, D.J.; McHarg, M.G.

    1999-01-01

    The polar cap (PC) index measures the level of geomagnetic activity in the polar cap based on magnetic perturbations from overhead ionospheric currents and distant field-aligned currents on the poleward edge of the nightside auroral oval. Because PC essentially measures the main sources of energy...

  17. Temperature Distribution within a Cold Cap during Nuclear Waste Vitrification

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, Derek R.; Schweiger, Michael J.; Riley, Brian J.; Pokorny, Richard; Hrma, Pavel R.

    2015-07-21

    The kinetics of the feed-to-glass conversion affects the waste vitrification rate in an electric melter. The primary area of interest in this conversion process is the cold cap, a layer of reacting feed on top of molten glass. Knowing the temperature profile within a cold cap will help determine its characteristics and relate them to the rate of glass production. The work presented here provides an experimental determination of the temperature distribution within the cold cap. Since a direct measurement of the temperature field within the cold cap is impracticable, an indirect method was developed where the textural features in a laboratory-made cold cap with a high-level waste feed were mapped as a function of position using optical microscopy, scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. To correlate the temperature distribution to microstructures within the cold cap, microstructures were identified of individual feed samples that were heat treated to set temperatures between 400°C and 1200°C and quenched. The temperature distribution within the cold cap was then established by correlating cold-cap regions with the feed samples of nearly identical structures and was compared with the temperature profile from a mathematical model.

  18. IN SITU REMEDIATION OF CONTAMINATED SEDIMENTS - ACTIVE CAPPING TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    Knox, A.; Roberts, J.; Paller, M.; Reible, D.

    2010-09-02

    Active capping is a relatively new approach for treating contaminated sediments. It involves applying chemically reactive amendments to the sediment surface. The main role of active caps is to stabilize contaminants in contaminated sediments, lower the bioavailable pool of contaminants, and reduce the release of contaminants to the water column. Metals are common contaminants in many marine and fresh water environments as a result of industrial and military activities. The mobile, soluble forms of metals are generally considered toxic. Induced chemical precipitation of these metals can shift toxic metals from the aqueous phase to a solid, precipitated phase which is often less bioavailable. This approach can be achieved through application of sequestering agents such as rock phosphates, organoclays, zeolites, clay minerals, and biopolymers (e.g., chitosan) in active capping technology. Active capping holds great potential for a more permanent solution that avoids residual risks resulting from contaminant migration through the cap or breaching of the cap. In addition to identifying superior active capping agents, research is needed to optimize application techniques, application rates, and amendment combinations that maximize sequestration of contaminants. A selected set of active capping treatment technologies has been demonstrated at a few sites, including a field demonstration at the Savannah River Site, Aiken, SC. This demonstration has provided useful information on the effects of sequestering agents on metal immobilization, bioavailability, toxicity, and resistance to mechanical disturbance.

  19. 47 CFR 61.41 - Price cap requirements generally.

    Science.gov (United States)

    2010-10-01

    ... party to a merger, acquisition, or similar transaction shall continue to be subject to price cap... no later than one year following the effective date of such merger, acquisition, or similar... subject to price cap regulation, as that term is defined in § 61.3(ee), which are involved in...

  20. ATLAS end-caps 
on the move

    CERN Multimedia

    2007-01-01

    Two delicate and spectacular transport operations have been performed for ATLAS in recent weeks: the first end-cap tracker was installed in its final position, and one of the huge end-caps of the toroid magnet was moved to the top of the experiment’s shaft.

  1. Marine bird sighting and other data from the COMMANDO and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 16 May 1978 to 09 September 1978 (NODC Accession 8100584)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the COMMANDO and other platforms from 6 May 1978 to 09 September 1978. Data were collected by the Fish and...

  2. Drifting buoy and other data from drifting platforms in the Bering Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 17 January 1981 to 20 June 1981 (NODC Accession 8200120)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Drifting buoy data was collected from drifting platforms in the Bering Sea by the Flow Research Company as part of the Outer Continental Shelf Environmental...

  3. Temperature profiles from XBT casts from the ACTIVE and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1979-02-01 to 1979-04-01 (NODC Accession 7900172)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the ACTIVE and other platforms from 01 February 1979 to 01 April 1979. Data were collected by the National...

  4. Marine bird sighting and other data from NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1975-06-05 to 1976-08-20 (NODC Accession 7800486)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from NOAA Ship DISCOVERER and other platforms. Data were collected as part of the Outer Continental Shelf...

  5. Phytoplankton and other data from net and bottle casts in the Beaufort Sea from aircraft and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 07 June 1975 to 30 September 1975 (NODC Accession 7601542)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Phytoplankton and other data were collected from net and bottle casts in the Beaufort Sea from aircraft and other platforms from 07 June 1975 to 30 September 1975....

  6. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 12 May 1975 to 22 August 1975 (NODC Accession 7601354)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 12 May 1975 to 22 August 1975. Data were collected by the Institute of...

  7. Temperature profile data from surface sensors and CTD casts from NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1981-10-22 to 1982-10-13 (NODC Accession 8400037)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected from surface sensors and CTD casts from NOAA Ship DISCOVERER and other platforms from 22 October 1981 to 13 October 1982....

  8. Fish pathology and other data from NOAA Ship MILLER FREEMAN and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1976-09-02 to 1978-08-27 (NODC Accession 8000026)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish Pathology and other data were collected from NOAA Ship MILLER FREEMAN and other platforms from 02 September 1976 to 27 August 1978. Data were collected by the...

  9. Marine bird sighting and other data from platforms in the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 11 June 1975 to 05 September 1975 (NODC Accession 7601518)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms in the Beaufort Sea from 11 June 1975 to 05 September 1975. Data were collected by the University...

  10. Marine bird sighting and other data from platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 28 May 1978 to 09 September 1978 (NODC Accession 8100312)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms from 28 May 1978 to 09 September 1978. Data were collected by the University of California (UC) as...

  11. Marine bird sighting and other data from platform as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 04 June 1976 to 24 August 1976 (NODC Accession 7700707)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform from 04 June 1976 to 24 August 1976. Data were collected by the University of Alaska; Institute of...

  12. Marine bird land sighting and other data from platforms from Pribilof Island as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 23 June 1975 to 11 August 1975 (NODC Accession 7601386)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird land sighting and other data were collected from platforms from Pribilof Island from 23 June 1975 to 11 August 1975. Data were collected by the...

  13. Marine bird sighting and other data from platform as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 08 May 1977 to 18 September 1977 (NODC Accession 7700778)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform from 08 May 1977 to 18 September 1977. Data were collected by the University of Alaska; Institute...

  14. Marine bird sighting and other data from platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 June 1977 to 09 September 1977 (NODC Accession 7900255)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms from 01 June 1977 to 09 September 1977. Data were collected by the University of California (UC) as...

  15. Marine bird colony and other data from platforms in the Bering Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 15 June 1975 to 15 October 1976 (NODC Accession 7700654)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird colony and other data were collected from platforms in the Bering Sea from 15 June 1975 to 15 October 1976. Data were collected by the College of the...

  16. Marine bird sighting and other data from platform from Kotzebue Sound as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 10 July 1976 to 10 September 1977 (NODC Accession 7900079)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform in the Kotzebue Sound from 10 July 1976 to 10 September 1977. Data were collected by the Institute...

  17. Marine bird sighting and other data from platform in the Bering Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 06 May 1976 to 19 August 1976 (NODC Accession 7700132)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from a platform in the Bering Sea from 06 May 1976 to 19 August 1976. Data were collected by the University of...

  18. Marine bird sighting and other data from platforms in the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 08 June 1976 to 17 September 1976 (NODC Accession 7700308)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from platforms in the Beaufort Sea from 08 June 1976 to 17 September 1976. Data were collected by the University...

  19. Benthic organism and other data from the USCGC GLACIER and other platforms from the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 17 May 1976 to 01 September 1976 (NODC Accession 7700242)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Benthic organism and other data were collected in the Beaufort Sea from the USCGC GLACIER and other platforms by Oregon State University (OSU). Data were collected...

  20. Benthic organism and other data from ALUMIAK and other platforms from the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 20 August 1976 to 11 November 1976 (NODC Accession 7700338)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Benthic organism and other data were collected in the Beaufort Sea from the ALUMIAK and other platforms by Oregon State University (OSU). Data were collected as part...

  1. Temperature profiles from XBT casts from the SANTA CRUZ and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1975-06-22 to 1975-09-17 (NODC Accession 7500932)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the SANTA CRUZ and other platforms from 22 June 1975 to 17 September 1975. Data were collected by Grace...

  2. Chlorophyll a and Other Data from NOAA Ship ALBATROSS IV and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1977-03-16 to 1985-06-04 (NODC Accession 9800126)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chlorophyll a and other data were collected from NOAA Ship ALBATROSS IV and other platforms from 16 March 1977 to 04 June 1985. Data were collected by the University...

  3. Temperature profiles from XBT casts from the SANTA CRUZ and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1974-10-01 to 1974-11-28 (NODC Accession 7400823)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the SANTA CRUZ and other platforms from 01 October 1974 to 28 November 1974. Data were collected by the Delta...

  4. Marine toxic substance and other data from bottle casts from the USCGC GLACIER and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 03 August 1977 to 03 September 1977 (NODC Accession 8000247)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from bottle casts from the USCGC GLACIER and other platforms from 03 August 1977 to 03 September 1977. Data were...

  5. Marine toxic substance and other data from bottle casts from NOAA Ship DISCOVERER and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1977-03-22 to 1978-08-18 (NODC Accession 8000246)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from bottle casts from NOAA Ship DISCOVERER and other platforms from 22 March 1977 to 18 August 1978. Data were...

  6. Marine toxic substance and other data from grab casts from the ACONA and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 July 1974 to 31 August 1978 (NODC Accession 8100533)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from grab casts from the ACONA and other platforms from 01 July 1974 to 31 August 1978. Data were collected by...

  7. Marine bird sighting, marine toxic substance, and other data from NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1976-03-25 to 1978-05-02 (NODC Accession 7900171)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting, marine toxic substance, and other data were collected from NOAA Ship DISCOVERER and other platforms from 25 March 1976 to 02 May 1978. Data...

  8. Marine toxic substance and other data from bottle casts from NOAA Ship DISCOVERER and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1977-11-11 to 1978-08-01 (NODC Accession 7900267)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine toxic substance and other data were collected from bottle casts from NOAA Ship DISCOVERER and other platforms from 11 November 1977 to 01 August 1978. Data...

  9. Marine animal sighting and census data from the RESOLUTE and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 15 June 1971 to 29 September 1977 (NCEI Accession 7800682)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from the RESOLUTE and other platforms from 15 June 1971 to 29 September 1977. Data were collected by the...

  10. Zooplankton and other data from net casts from the ACONA and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 02 July 1974 to 15 May 1975 (NODC Accession 7601458)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Zooplankton and other data were collected from net casts from the ACONA and other platforms from 02 July 1974 to 15 May 1975. Data were collected by the University...

  11. Marine bird sighting and other data from NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1975-08-12 to 1976-11-06 (NODC Accession 7800516)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from NOAA Ship DISCOVERER and other platforms from 12 August 1975 to 06 November 1976. Data were collected by...

  12. Temperature profiles from XBT casts from the MARINE EVANGELINE and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1981-06-03 to 1981-11-20 (NODC Accession 8100721)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the MARINE EVANGELINE and other platforms from 03 June 1981 to 20 November 1981. Data were collected by the...

  13. Oceanographic station, meteorological, and other data from bottle casts from the DAN BRAMAN and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 07 May 1971 to 25 August 1971 (NODC Accession 7201264)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic station, meteorological, and other data were collected from bottle casts from the DAN BRAMAN and other platforms from 07 May 1971 to 25 August 1971....

  14. Primary productivity and other data from bottle casts from NOAA Ship DISCOVERER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 1977-03-18 to 1977-06-09 (NCEI Accession 7800449)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Primary productivity and other data were collected from bottle casts from NOAA Ship DISCOVERER and other platforms from 18 March 1977 to 09 June 1977. Data were...

  15. Temperature profiles from XBT casts from the SANTA CRUZ and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1972-09-01 to 1972-11-05 (NODC Accession 7201439)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the SANTA CRUZ and other platforms from 01 September 1972 to 05 November 1972. Data were collected by the...

  16. Fish survey, fishing duration, and other data from net trawls from the BARGE and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 16 June 1976 to 30 March 1977 (NODC Accession 7800030)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish survey, fishing duration, and other data were collected from net trawls from the BARGE and other platforms from 16 June 1976 to 30 March 1977. Data were...

  17. Fish survey, fishing duration, and other data from net trawls from the BARGE and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 30 May 1977 to 13 October 1977 (NODC Accession 7800268)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish survey, fishing duration, and other data were collected from net trawls from the BARGE and other platforms from 30 May 1977 to 13 October 1977. Data were...

  18. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 22 November 1977 to 21 August 1979 (NODC Accession 8000047)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 22 November 1977 to 21 August 1979. Data were collected by the Alaska...

  19. Current and other data from meters attached to fixed platforms in the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 08 August 1977 to 01 September 1977 (NODC Accession 8000055)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current and other data were collected from meters attached to fixed platforms in the Beaufort Sea by the University of Alaska, Fairbanks (UAF). Data were collected...

  20. Marine bird habitat and other data from the BARGE and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 28 April 1978 to 16 August 1978 (NODC Accession 7900063)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird habitat and other data were collected from the BARGE and other platforms from 28 April 1978 to 16 August 1978. Data were collected by the Alaska State...

  1. Marine bird colony and other data from land platforms on St. George Island as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 20 June 1975 to 08 August 1975 (NODC Accession 7700108)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird colony and other data were collected from land platforms on St. George Island from 20 June 1975 to 08 August 1975. Data were collected by the University...

  2. Marine bird colony and other data from platforms on as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 15 May 1977 to 05 September 1977 (NODC Accession 7800777)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird colony and other data were collected from platforms from 15 May 1977 to 05 September 1977. Data were collected by the University of California (UC) as...

  3. Marine bird sighting and other data from the BARGE and other platforms from Beaufort Sea and other locations as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 07 May 1976 to 15 October 1976 (NODC Accession 7800031)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the BARGE and other platforms from the Beaufort Sea and other locations from 07 May 1976 to 15 October 1976....

  4. Marine bird sighting and other data from the GLACIER and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 02 August 1977 to 06 September 1977 (NODC Accession 8100583)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the GLACIER and other platforms from 02 August 1977 to 06 September 1977. Data were collected by the Point...

  5. Marine bird sighting and other data from the BURTON ISLAND and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 30 July 1975 to 12 August 1978 (NODC Accession 7800157)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from the BURTON ISLAND and other platforms from 30 July 1975 to 12 August 1978. Data were collected by the Point...

  6. Current and other data from meters on fixed platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 13 November 1980 to 03 June 1981 (NODC Accession 8400019)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current and other data were collected from meters on fixed platforms from 13 November 1980 to 03 June 1981. Data were collected by Science Applications, Inc. (SAI)...

  7. Current and other data from meters attached to fixed platforms in the Beaufort Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 16 May 1978 to 01 November 1978 (NODC Accession 8100005)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current and other data were collected from meters attached to fixed platforms in the Beaufort Sea by the University of Alaska - Fairbanks (UAF). Data were collected...

  8. Phytoplankton and other data from net and bottle casts from the ICE ISLANDS and other platforms as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 19 April 1979 to 23 June 1980 (NODC Accession 8200100)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Phytoplankton and other data were collected from net and bottle casts from the ICE ISLANDS and other platforms from 19 April 1979 to 23 June 1980. Data were...

  9. Temperature profiles from XBT casts from the DECATUR and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1969-08-30 to 1983-03-31 (NODC Accession 8300047)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the DECATUR and other platforms from 30 August 1969 to 31 March 1983. Data were collected by the National...

  10. Temperature profiles from XBT casts from NOAA Ship DELAWARE II and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1971-04-01 to 1972-10-01 (NCEI Accession 7300061)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile were collected from XBT casts from NOAA Ship DELAWARE II and other platforms from 01 April 1971 to 01 October 1972. Data were collected by the...

  11. Temperature profiles from XBT casts from the MARINE EVANGELINE and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1979-06-03 to 1979-06-28 (NODC Accession 7900220)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the MARINE EVANGELINE and other platforms from 03 June 1979 to 28 June 1979. Data were collected by the...

  12. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 07 March 1977 to 19 September 1977 (NODC Accession 7800158)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms from 07 March 1977 to 19 September 1977. Data were collected by the Alaska State...

  13. Feeding flock and other data from ACONA and other platforms from the Bering Sea and other locations as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 04 August 1975 to 16 September 1976 (NODC Accession 7700775)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Feeding flock and other data were collected from the ACONA and other platforms in the Bering Sea and other locations. Data were collected by Oregon State University...

  14. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 09 January 1975 to 09 December 1975 (NODC Accession 7800865)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms. Data were collected by the Fish and Wildlife Service (FWS) as part of the Outer...

  15. Marine bird sighting and other data from aircraft and other platforms from the Bering Sea and North Pacific as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 09 February 1976 to 01 October 1976 (NODC Accession 7800904)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms in the Bering Sea and North Pacific. Data were collected by the Fish and...

  16. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 21 April 1975 to 05 October 1977 (NODC Accession 7800812)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms from 21 April 1975 to 05 October 1977.. Data were collected by the Fish and...

  17. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 06 March 1975 to 21 March 1976 (NODC Accession 7900039)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms. Data were collected by the Fish and Wildlife Service (FWS) as part of the Outer...

  18. Marine bird sighting and other data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 18 June 1975 to 04 April 1976 (NODC Accession 7800721)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine bird sighting and other data were collected from aircraft and other platforms from 18 June 1975 to 04 April 1976. Data were collected by the Fish and Wildlife...

  19. Marine mammal specimen and other data from the SURVEYOR and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 20 March 1977 to 02 November 1977 (NODC Accession 7900319)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine mammal specimen and other data were collected from the SURVEYOR and other platforms from 20 March 1977 to 02 November 1977. Data were collected by the Alaska...

  20. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 01 June 1972 to 07 September 1976 (NODC Accession 7700541)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 01 June 1972 to 07 September 1976. Data were collected by the U.S. Fish...

  1. Marine animal sighting and census data from aircraft and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 11 May 1982 to 14 August 1982 (NODC Accession 8400075)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine animal sighting and census data were collected from aircraft and other platforms from 11 May 1982 to 14 August 1982. Data were collected by Envirosphere Co....

  2. Current, pressure gauge, and other data from instruments attached to fixed platforms in the Bering Sea as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 16 September 1977 to 20 September 1978 (NODC Accession 8000024)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current, pressure gauge, and other data were collected from instruments attached to fixed platforms in the Bering Sea from the 16 September 1977 to 20 September...

  3. Temperature profiles from XBT casts from the DELTA ECUADOR and other platforms as part of the Marine Resources Monitoring, Assessment and Prediction (MARMAP) project from 1978-09-30 to 1978-10-05 (NODC Accession 7800858)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profiles were collected from XBT casts from the DELTA ECUADOR and other platforms from 30 September 1978 to 05 October 1978. Data were collected by the...

  4. Marine mammal specimen and marine animal sighting data from the USCGC POLAR STAR and other platforms as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 25 February 1981 to 04 December 1981 (NODC Accession 8300129)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Marine mammal specimen and marine animal sighting data were collected from the USCGC POLAR STAR and other platforms from 25 February 1981 to 04 December 1981. Data...

  5. Progress in LAr EndCap Calorimetry: News from the Hadronic EndCap Group.

    CERN Multimedia

    Oram, C.J.

    With module production and testing completed for the Hadronic EndCap calorimeter, the attention of the HEC group is heavily directed towards wheel assembly in building 180. Three of the four HEC wheels are now assembled and rotated, and work is progressing on assembling the final wheel. This year has been a busy year for the installation of components in the EndCap C cryostat: the signal feedthrough installation was completed April 22nd, the pre-sampler shortly thereafter and the Electro-Magnetic EndCap August 13th. This allowed the HEC group to start transferring the HEC wheels from the T6A storage cradle into the cryostat. The operation started in mid-September and has progressed, on or ahead of schedule, since then with the major milestones being: Insertion of 67 ton front HEC wheel October 3rd Insertion of 90 ton rear HEC wheel October 22nd. The wheel alignment has proved to be excellent, with the position of the centre of the front(rear) wheel with respect to the nominal position being displaced b...

  6. PR-PR: cross-platform laboratory automation system.

    Science.gov (United States)

    Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

    2014-08-15

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  7. PR-PR: Cross-Platform Laboratory Automation System

    Energy Technology Data Exchange (ETDEWEB)

    Linshiz, G; Stawski, N; Goyal, G; Bi, CH; Poust, S; Sharma, M; Mutalik, V; Keasling, JD; Hillson, NJ

    2014-08-01

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  8. Development, genetic mapping and QTL association of cotton PHYA, PHYB, and HY5-specific CAPS and dCAPS markers

    Science.gov (United States)

    Among SNP markers that become increasingly valuable in molecular breeding of crop plants are the CAP and dCAP markers derived from the genes of interest. To date, the number of such gene-based markers is small in polyploid crop plants such as tetraploid cotton that has A and D subgenomes. The obje...

  9. The Geohazards Exploitation Platform

    Science.gov (United States)

    Laur, Henri; Casu, Francesco; Bally, Philippe; Caumont, Hervé; Pinto, Salvatore

    2016-04-01

    The Geohazards Exploitation Platform, or Geohazards TEP (GEP), is an ESA originated R&D activity of the EO ground segment to demonstrate the benefit of new technologies for large scale processing of EO data. This encompasses on-demand processing for specific user needs, systematic processing to address common information needs of the geohazards community, and integration of newly developed processors for scientists and other expert users. The platform supports the geohazards community's objectives as defined in the context of the International Forum on Satellite EO and Geohazards organised by ESA and GEO in Santorini in 2012. The GEP is a follow on to the Supersites Exploitation Platform (SSEP) an ESA initiative to support the Geohazards Supersites & Natural Laboratories initiative (GSNL). Today the GEP allows to exploit 70+ Terabyte of ERS and ENVISAT archive and the Copernicus Sentinel-1 data available on line. The platform has already engaged 22 European early adopters in a validation activity initiated in March 2015. Since September, this validation has reached 29 single user projects. Each project is concerned with either integrating an application, running on demand processing or systematically generating a product collection using an application available in the platform. The users primarily include 15 geoscience centres and universities based in Europe: British Geological Survey (UK), University of Leeds (UK), University College London (UK), ETH University of Zurich (CH), INGV (IT), CNR-IREA and CNR-IRPI (IT), University of L'Aquila (IT), NOA (GR), Univ. Blaise Pascal & CNRS (FR), Ecole Normale Supérieure (FR), ISTERRE / University of Grenoble-Alpes (FR). In addition, there are users from Africa and North America with the University of Rabat (MA) and the University of Miami (US). Furthermore two space agencies and four private companies are involved: the German Space Research Centre DLR (DE), the European Space Agency (ESA), Altamira Information (ES

  10. Rationale and design of the Baptist Employee Healthy Heart Study:A randomized trial assessing the efficacy of the addition of an interactive, personalized, web-based, lifestyle intervention tool to an existing health information web platform in a high-risk employee population

    OpenAIRE

    Post, Janisse M.; Ali, Shozab S.; Roberson, Lara L; Aneni, Ehimen C.; Shaharyar, Sameer; Younus, Adnan; Jamal, Omar; Ahmad, Rameez; Aziz, Muhammad; Malik, Rehan; Spatz, Erica S.; Feldman, Theodore; Fialkow, Jonathan; Veledar, Emir; Cury, Ricardo C.

    2016-01-01

    Background: Metabolic syndrome (MetS) and diabetes confer a high risk for developing subsequent cardiovascular disease (CVD). Persons with MetS constitute 24-34 % of the employee population at Baptist Health South Florida (BHSF), a self-insured healthcare organization. The Baptist Employee Healthy Heart Study (BEHHS) aims to assess the addition of a personalized, interactive, web-based, nutrition-management and lifestyle-management program to the existing health-expertise web platform availab...

  11. Rationale and design of the Baptist Employee Healthy Heart Study: a randomized trial assessing the efficacy of the addition of an interactive, personalized, web-based, lifestyle intervention tool to an existing health information web platform in a high-risk employee population

    OpenAIRE

    Post, Janisse M.; Ali, Shozab S.; Roberson, Lara L; Aneni, Ehimen C.; Shaharyar, Sameer; Younus, Adnan; Jamal, Omar; Ahmad, Rameez; Aziz, Muhammad A.; Malik, Rehan; Spatz, Erica S.; Feldman, Theodore; Fialkow, Jonathan; Veledar, Emir; Cury, Ricardo C.

    2016-01-01

    Background Metabolic syndrome (MetS) and diabetes confer a high risk for developing subsequent cardiovascular disease (CVD). Persons with MetS constitute 24–34 % of the employee population at Baptist Health South Florida (BHSF), a self-insured healthcare organization. The Baptist Employee Healthy Heart Study (BEHHS) aims to assess the addition of a personalized, interactive, web-based, nutrition-management and lifestyle-management program to the existing health-expertise web platform availabl...

  12. Promoting Assessment Efficacy through an Integrated System for Online Clinical Assessment of Practical Skills

    Science.gov (United States)

    Hay, Peter J.; Engstrom, Craig; Green, Anita; Friis, Peter; Dickens, Sue; Macdonald, Doune

    2013-01-01

    This paper presents evaluation outcomes from an externally funded research project involving the online clinical assessment of practical skills (eCAPS) using web-based video technologies within a university medical programme. eCAPS was implemented to trial this web-based approach for promoting the efficacy of "practical" skills assessment in knee…

  13. Cots Correlator Platform

    Science.gov (United States)

    Schaaf, Kjeld; Overeem, Ruud

    2004-06-01

    Moore’s law is best exploited by using consumer market hardware. In particular, the gaming industry pushes the limit of processor performance thus reducing the cost per raw flop even faster than Moore’s law predicts. Next to the cost benefits of Common-Of-The-Shelf (COTS) processing resources, there is a rapidly growing experience pool in cluster based processing. The typical Beowulf cluster of PC’s supercomputers are well known. Multiple examples exists of specialised cluster computers based on more advanced server nodes or even gaming stations. All these cluster machines build upon the same knowledge about cluster software management, scheduling, middleware libraries and mathematical libraries. In this study, we have integrated COTS processing resources and cluster nodes into a very high performance processing platform suitable for streaming data applications, in particular to implement a correlator. The required processing power for the correlator in modern radio telescopes is in the range of the larger supercomputers, which motivates the usage of supercomputer technology. Raw processing power is provided by graphical processors and is combined with an Infiniband host bus adapter with integrated data stream handling logic. With this processing platform a scalable correlator can be built with continuously growing processing power at consumer market prices.

  14. Tailoring capping layers to reduce stress gradients in copper metallization

    Science.gov (United States)

    Murray, Conal E.; Priyadarshini, Deepika; Nguyen, Son; Ryan, E. Todd

    2016-12-01

    Capping layers for back-end-of-line metallization, which primarily serve as diffusion barriers to prevent contamination, also play a role in mitigating electromigration in the underlying conductive material. Stress gradients can be generated in copper metallization due to the conditions associated with the capping process. To study the effects of deposition and subsequent annealing on the mechanical response of copper films with various capping schemes, we employed a combination of conventional and glancing incidence X-ray diffraction techniques to quantify the stress gradient maxima. The Cu films with dielectric caps, such as silicon nitride, can exhibit large gradients that decrease slightly with thermal cycling. However, Co and TaN-based metallic capping layers create significantly lower stress gradient maxima in copper features both before and after annealing. The different evolution of stress gradients in Cu films with dielectric and metallic caps due to thermal cycling reveals the interaction of dislocation-mediated, plastic deformation with the cap/Cu interface.

  15. Protection of Drosophila chromosome ends through minimal telomere capping.

    Science.gov (United States)

    Dubruille, Raphaëlle; Loppin, Benjamin

    2015-05-15

    In Drosophila, telomere-capping proteins have the remarkable capacity to recognize chromosome ends in a sequence-independent manner. This epigenetic protection is essential to prevent catastrophic ligations of chromosome extremities. Interestingly, capping proteins occupy a large telomere chromatin domain of several kilobases; however, the functional relevance of this to end protection is unknown. Here, we investigate the role of the large capping domain by manipulating HOAP (encoded by caravaggio) capping-protein expression in the male germ cells, where telomere protection can be challenged without compromising viability. We show that the exhaustion of HOAP results in a dramatic reduction of other capping proteins at telomeres, including K81 [encoded by ms(3)K81], which is essential for male fertility. Strikingly however, we demonstrate that, although capping complexes are barely detected in HOAP-depleted male germ cells, telomere protection and male fertility are not dramatically affected. Our study thus demonstrates that efficient protection of Drosophila telomeres can be achieved with surprisingly low amounts of capping complexes. We propose that these complexes prevent fusions by acting at the very extremity of chromosomes, reminiscent of the protection conferred by extremely short telomeric arrays in yeast or mammalian systems.

  16. Native Grasses as a Management Alternative on Vegetated Closure Caps

    Science.gov (United States)

    Kwit, Charles; Collins, Beverly

    2008-06-01

    Capped waste sites often are vegetated with commercial turf grasses to increase evapotranspiration and prevent erosion and possible exposure of the barrier. Fertilizer, frequent watering, and mowing may be required to establish the turf grass and prevent invasion by trees and shrubs. Oldfield vegetation of grasses and forbs is a possible sustainable alternative to turf grass communities. To determine if oldfield vegetation can establish on caps, we (1) compared establishment of a dominant oldfield grass and a commercial turf grass under different combinations of new closure cap management: spring or summer planting and presence or absence of amendments to alleviate drought (watering, mulch) or increase soil fertility (fertilizer, lime, a nitrogen-fixing legume); (2) surveyed existing caps to determine if oldfield species establish naturally; and (3) performed a greenhouse experiment to compare growth of two native grasses under low and amended (added water, soil nutrients) conditions. Both the commercial grass and oldfield species established under new cap conditions; fertilizer, water, and mulch improved vegetation establishment in spring or summer, but legumes decreased grass cover. In the greenhouse, both native grasses grew best with amendments; however, substantial stem and root length were obtained with no fertilizer and only once-weekly watering. Existing vegetated caps supported planted grasses and naturally established oldfield species. Overall, the results indicate native grasses can establish on new caps and oldfields can serve as a management model; further work is needed to determine the management strategy to maintain herbaceous vegetation and slow woody species invasion.

  17. Trafficking of. cap alpha. -L-fucosidase in lymphoid cells

    Energy Technology Data Exchange (ETDEWEB)

    DiCioccio, R.A.; Brown, K.S.

    1987-05-01

    The quantity of ..cap alpha..-L-fucosidase in human serum is determined by heredity. The mechanism controlling levels of the enzyme in serum is unknown. To investigate this, lymphoid cell lines derived from individuals with either low, intermediate or high ..cap alpha..-L-fucosidase in serum were established. Steady state levels of extracellular ..cap alpha..-L-fucosidase protein and activity overlapped among the cell lines. Thus, in vivo serum phenotypes of ..cap alpha..-L-fucosidase are not adequately expressed in this system. ..cap alpha..-L-Fucosidase was also metabolically labelled with /sup 35/S-methionine, immunoprecipitated, and examined by SDS-PAGE. Cells pulse-labelled from 0.25-2 h had a major intracellular form of enzyme (Mr = 58,000). Cells pulsed for 1.5 h and chased for 21 h with unlabeled methionine had an intracellular form of Mr = 60,000 and an extracellular form of Mr = 62,000. Cells treated with chloroquine had only the 58,000-form both intra- and extra-cellularly. Moreover, chloroquine did not effect the quantitative distribution of ..cap alpha..-L-fucosidase between cells and medium. In fibroblasts, chloroquine enhanced the secretion of newly made lysosomal enzymes and blocked the processing of intercellular enzyme forms from a higher to a lower molecular mass. Thus, there are trafficking differences between ..cap alpha..-L-fucosidase in lymphoid cells and lysosomal enzymes in fibroblasts. This suggests that alternative targeting mechanisms for lysosomal enzymes exist in these cells.

  18. ALICE Connex : Mobile Volunteer Computing and Edutainment Platform

    CERN Document Server

    Chalumporn, Gantaphon

    2016-01-01

    Mobile devices are very powerful and trend to be developed. They have functions that are used in everyday life. One of their main tasks is to be an entertainment devices or gaming platform. A lot of technologies are now accepted and adopted to improve the potential of education. Edutainment is a combination of entertainment and education media together to make use of both benefits. In this work, we introduce a design of edutainment platform which is a part of mobile volunteer computing and edutainment platform called ‘ALICE Connex’ for ALICE at CERN. The edutainment platform focuses to deliver enjoyment and education, while promotes ALICE and Volunteer Computing platform to general public. The design in this work describes the functionality to build an effective edutainment with real-time multiplayer interaction on round-based gameplay, while integrates seamless edutainment with basic particle physic content though game mechanism and items design. For the assessment method we will observe the enjoyment o...

  19. VALIDIFICATION OF SMART-COP IN PREDICTING THE NEED FOR IRVS IN COMMUNITY ACQUIRED PNEUMONIA (CAP PATIENTS

    Directory of Open Access Journals (Sweden)

    Uphar

    2015-12-01

    Full Text Available Pneumonia has been considered a health problem for ages. Despite being the cause of significant morbidity and mortality. Delay in ICU admission of CAP patients has been shown to be associated with increased mortality. The ‘SMART-COP’ is a simple tool that is the result of an extensive study on CAP called the Australian CAP Study (ACAPS. OBJECTIVE To assess the validity the SMART-COP severity scoring tool in patients of Community Acquired Pneumonia (CAP. MATERIALS AND METHODS Fifty patients of CAP admitted in the intensive care units of R. L. Jalappa Hospital, Kolar, above the age of 18yrs with a diagnosis of community acquired pneumonia. RESULTS We noted a progression in the need for ICU support and need for ventilatory and ionotropic support with increasing score assigned on the SMART-COP. Thirty day mortality in the patients also showed a linear pattern with increase in the score assigned to the patients. Mortality was high in the very high risk group and high risk group. CONCLUSION With 68.5% of the patients requiring invasive ventilator support and 75% of the patients requiring inotropic support in the high risk group, it can be safely concluded that SMART-COP scoring system can be used in the patients of community acquired pneumonia to predict the need for IRVS.

  20. Magnetic reversals in basal Ediacaran cap carbonates: A critical review

    Science.gov (United States)

    Raub, T. D.; Evans, D. A.

    2006-05-01

    At least one paleomagnetic reversal has been reported from each of three "Snowball Earth" postglacial cap cabonate units: Walsh cap of Kimberley, northern Australia; Mirassol d'Oeste in Amazonia; and Hadash in Oman. Our data from Nuccaleena cap dolostone of South Australia add a fourth to that list. We critically review all four studies and note that: a) Strict stratigraphic control on position of reversals is only documented for Mirassol d'Oeste and Nuccaleena caps. The Walsh cap sites are not stratigraphically constrained, and the Hadash reversal stratigraphy is only apparent after site data are combined from sections separated by 10's to 100's of km. b) Although Walsh, Hadash, and Nuccaleena remanences pass regional fold tests, the folding events could be substantially younger than cap deposition. Dual-polarity remagnetizations are well-documented in other carbonates. Despite satisfactory rock-magnetic results from Mirassol d'Oeste, critical field stability tests on the age of magnetization are lacking. c) Indirect syn-sedimentary tests of magnetization are only documented and passed for Nuccaleena dolostone. Mean Nuccaleena magnetization directions are similar to those of the paraconformably underlying glacial Elatina Formation, which passes a synsedimentary fold test; and two postglacial reversal levels are correlatable across three sections and ~50 km of nearly continuous on-strike exposure. d) Reversals from Mirassol d'Oeste and Nuccaleena cap carbonates cannot correlate directly with each other if post-Snowball paleooceanographic carbon isotope trends or values are assumed to be globally synchronous. Allowing for complex ocean chemistry, the two units could be broadly coeval, but if both paleomagnetic signals are primary then they must be diachronous on polarity-zone timescales. e) Given the pattern of observed reversal profiles established with confidence for at least the Nuccaleena cap, we contend that only magnetostratigraphic studies of high spatial

  1. Influenza A virus preferentially snatches noncoding RNA caps.

    Science.gov (United States)

    Gu, Weifeng; Gallagher, Glen R; Dai, Weiwei; Liu, Ping; Li, Ruidong; Trombly, Melanie I; Gammon, Don B; Mello, Craig C; Wang, Jennifer P; Finberg, Robert W

    2015-12-01

    Influenza A virus (IAV) lacks the enzyme for adding 5' caps to its RNAs and snatches the 5' ends of host capped RNAs to prime transcription. Neither the preference of the host RNA sequences snatched nor the effect of cap-snatching on host processes is completely defined. Previous studies of influenza cap-snatching used poly(A)-selected RNAs from infected cells or relied on annotated host genes to define the snatched host RNAs, and thus lack details on many noncoding host RNAs including snRNAs, snoRNAs, and promoter-associated capped small (cs)RNAs, which are made by "paused" Pol II during transcription initiation. In this study, we used a nonbiased technique, CapSeq, to identify host and viral-capped RNAs including nonpolyadenylated RNAs in the same samples, and investigated the substrate-product correlation between the host RNAs and the viral RNAs. We demonstrated that noncoding host RNAs, particularly U1 and U2, are the preferred cap-snatching source over mRNAs or pre-mRNAs. We also found that csRNAs are highly snatched by IAV. Because the functions of csRNAs remain mostly unknown, especially in somatic cells, our finding reveals that csRNAs at least play roles in the process of IAV infection. Our findings support a model where nascent RNAs including csRNAs are the preferred targets for cap-snatching by IAV and raise questions about how IAV might use snatching preferences to modulate host-mRNA splicing and transcription.

  2. Oxidation resistance of Ru-capped EUV multilayers

    Energy Technology Data Exchange (ETDEWEB)

    Bajt, S; Dai, Z; Nelson, E J; Wall, M A; Alameda, J; Nguyen, N; Baker, S; Robinson, J C; Taylor, J S; Clift, M; Aquila, A; Gullikson, E M; Edwards, N G

    2005-02-23

    Differently prepared Ru-capping layers, deposited on Mo/Si EUV multilayers, have been characterized using a suite of metrologies to establish their baseline structural, optical, and surface properties in as-deposited state. Same capping layer structures were tested for their thermal stability and oxidation resistance. Post-mortem characterization identified changes due to accelerated tests. The best performing Ru-capping layer structure was studied in detail with transmission electron microscopy to identify the grain microstructure and texture. This information is essential for modeling and performance optimization of EUVL multilayers.

  3. The CAP Theorem Versus Databases with Relaxed ACID properties

    DEFF Research Database (Denmark)

    Frank, Lars; Ulslev Pedersen, Rasmus; Frank, Christian Havnø

    2014-01-01

    -tolerance at the cost of a potentially low availability. Recently, Brewer [4] has modified the CAP theorem, pointing out that all the CAP properties are more or less continuous, and possible to optimize, weighing them against each other., in practice it is possible for an application area to have both relative high...... the traditional ACID properties and all the CAP properties were implemented. This optimizing is especially important in mobile integrated databases, where disconnections are normal and frequent. It is also important in distributed databases like EHR (electronic Health Records) where many different hospital...

  4. The catheter hub disinfection cap as esophageal foreign body.

    Science.gov (United States)

    Tawfik, Kareem O; Myer, Charles M; Shikary, Tasneem; Goldschneider, Kenneth R

    2015-12-01

    Disinfection caps are increasingly being used to prevent catheter-associated bloodstream infections. These devices, designed for continuous passive disinfection of catheter hubs, are typically small and often brightly colored. As such, they have the potential to become pediatric airway and esophageal foreign bodies. We report two patients who developed esophageal foreign body following ingestion of disinfection caps. Given the increasing use of these devices, it is imperative that health care providers be aware of this potential iatrogenic problem. We propose that the use of disinfection caps may not be appropriate in pediatric patients with risk factors for foreign body ingestion.

  5. Biomolecularly capped uniformly sized nanocrystalline materials: glutathione-capped ZnS nanocrystals

    Science.gov (United States)

    Torres-Martínez, Claudia L.; Nguyen, Liem; Kho, Richard; Bae, Weon; Bozhilov, Krassimir; Klimov, Victor; Mehra, Rajesh K.

    1999-09-01

    Micro-organisms such as bacteria and yeasts form CdS to detoxify toxic cadmium ions. Frequently, CdS particles formed in yeasts and bacteria were found to be associated with specific biomolecules. It was later determined that these biomolecules were present at the surface of CdS. This coating caused a restriction in the growth of CdS particles and resulted in the formation of nanometre-sized semiconductors (NCs) that exhibited typical quantum confinement properties. Glutathione and related phytochelatin peptides were shown to be the biomolecules that capped CdS nanocrystallites synthesized by yeasts Candida glabrata and Schizosaccharomyces pombe. Although early studies showed the existence of specific biochemical pathways for the synthesis of biomolecularly capped CdS NCs, these NCs could be formed in vitro under appropriate conditions. We have recently shown that cysteine and cysteine-containing peptides such as glutathione and phytochelatins can be used in vitro to dictate the formation of discrete sizes of CdS and ZnS nanocrystals. We have evolved protocols for the synthesis of ZnS or CdS nanocrystals within a narrow size distribution range. These procedures involve three steps: (1) formation of metallo-complexes of cysteine or cysteine-containing peptides, (2) introduction of stoichiometric amounts of inorganic sulfide into the metallo-complexes to initiate the formation of nanocrystallites and finally (3) size-selective precipitation of NCs with ethanol in the presence of Na+. The resulting NCs were characterized by optical spectroscopy, high-resolution transmission electron microscopy (HRTEM), x-ray diffraction and electron diffraction. HRTEM showed that the diameter of the ZnS-glutathione nanocrystals was 3.45+/-0.5 nm. X-ray diffraction and electron diffraction analyses indicated ZnS-glutathione to be hexagonal. Photocatalytic studies suggest that glutathione-capped ZnS nanocrystals prepared by our procedure are highly efficient in degrading a test model

  6. Utilizing platforms in industrialized construction

    DEFF Research Database (Denmark)

    Bonev, Martin; Wörösch, Michael; Hvam, Lars

    2015-01-01

    construction companies. A promising approach adapted by operations management and design theory regards individual building projects as the adjustment and recombination of components and processes from a set of predefined platforms, while configuration systems assure feasible building solutions. Design...... methods map structural platform characteristics so as to balance commonality and distinctiveness. Originality/value – This paper proposes a general theory of platform-based development and execution in the industrialised construction sector, which goes beyond concurrent approaches of standardising...

  7. Communications payloads for geostationary platforms

    Science.gov (United States)

    Fordyce, S. W.

    1978-01-01

    Trends in communication satellites show increasing reuse of the frequency spectrum through multiple spot beams and orthogonal polarization, as well as consortia operation. Current reliance on orbital arc separation for frequency reuse may be inadequate for the projected traffic growth and the orbital slotting proposals before the ITU. This paper notes that cost advantages can accrue through common use of spacecraft subsystems and multiple users' platforms aboard a common geostationary platform. The rationale for such platforms is described and potential payloads are suggested.

  8. Capítulo I: Contabilidad de costos - Capítulo II : Costos estimados

    OpenAIRE

    Rojas Medina, Ricardo Alfredo

    2014-01-01

    Me permito poner a su consideración los capítulos I y II del libro titulado: Costos un enfoque administrativo y de gerencia, contenido que fue realizado para mejorar y reestructurar el libro titulado Sistemas de costos un proceso para su implementación, que tuvo gran acogida dado el volumen de consulta y descarga del repositorio de la UN. En la primera unidad se trabaja lo referente a costos para la toma de decisiones, presentado un marco teórico y los fundamentos básicos del costeo direct...

  9. Web Platform Application

    Energy Technology Data Exchange (ETDEWEB)

    Paulsworth, Ashley [Sunvestment Group, Frederick, MD (United States); Kurtz, Jim [Sunvestment Group, Frederick, MD (United States); Brun de Pontet, Stephanie [Sunvestment Group, Frederick, MD (United States)

    2016-06-15

    Sunvestment Energy Group (previously called Sunvestment Group) was established to create a web application that brings together site hosts, those who will obtain the energy from the solar array, with project developers and funders, including affinity investors. Sunvestment Energy Group (SEG) uses a community-based model that engages with investors who have some affinity with the site host organization. In addition to a financial return, these investors receive non-financial value from their investments and are therefore willing to offer lower cost capital. This enables the site host to enjoy more savings from solar through these less expensive Community Power Purchase Agreements (CPPAs). The purpose of this award was to develop an online platform to bring site hosts and investors together virtually.

  10. Energy Tracking Software Platform

    Energy Technology Data Exchange (ETDEWEB)

    Ryan Davis; Nathan Bird; Rebecca Birx; Hal Knowles

    2011-04-04

    Acceleration has created an interactive energy tracking and visualization platform that supports decreasing electric, water, and gas usage. Homeowners have access to tools that allow them to gauge their use and track progress toward a smaller energy footprint. Real estate agents have access to consumption data, allowing for sharing a comparison with potential home buyers. Home builders have the opportunity to compare their neighborhood's energy efficiency with competitors. Home energy raters have a tool for gauging the progress of their clients after efficiency changes. And, social groups are able to help encourage members to reduce their energy bills and help their environment. EnergyIT.com is the business umbrella for all energy tracking solutions and is designed to provide information about our energy tracking software and promote sales. CompareAndConserve.com (Gainesville-Green.com) helps homeowners conserve energy through education and competition. ToolsForTenants.com helps renters factor energy usage into their housing decisions.

  11. Reproducible Experiment Platform

    CERN Document Server

    Likhomanenko, Tatiana; Baranov, Alexander; Khairullin, Egor; Ustyuzhanin, Andrey

    2015-01-01

    Data analysis in fundamental sciences nowadays is an essential process that pushes frontiers of our knowledge and leads to new discoveries. At the same time we can see that complexity of those analyses increases fast due to a)~enormous volumes of datasets being analyzed, b)~variety of techniques and algorithms one have to check inside a single analysis, c)~distributed nature of research teams that requires special communication media for knowledge and information exchange between individual researchers. There is a lot of resemblance between techniques and problems arising in the areas of industrial information retrieval and particle physics. To address those problems we propose Reproducible Experiment Platform (REP), a software infrastructure to support collaborative ecosystem for computational science. It is a Python based solution for research teams that allows running computational experiments on shared datasets, obtaining repeatable results, and consistent comparisons of the obtained results. We present s...

  12. The Creative Soccer Platform

    DEFF Research Database (Denmark)

    Johan Torp Rasmussen, Ludvig; Østergaard, Lars Domino

    2016-01-01

    ' creativity, The Creative Soccer Platform (TCSP), and to demonstrate the implications of applying it in youth soccer practice, by means of soccer-specific creativity exercises. TCSP encompasses four theoretically based didactic principles (task focus, parallel thinking, horizontal thinking, and no experienced......Creativity is essential in soccer due to the unpredictable and complex situations occurring in the game, where stereotypical play gradually loses its efficiency. Further, creativity is an important psychological factor for the development of soccer expertise, and valuing creativity increases...... satisfaction and well-being. Although creative players are highly desired by coaches, the subject of cultivating creativity is mostly ignored and traditional training settings may even hamper the players' creativity. The purpose of this article is to introduce a novel approach for enhancing soccer players...

  13. Flexible experimental FPGA based platform

    DEFF Research Database (Denmark)

    Andersen, Karsten Holm; Nymand, Morten

    2016-01-01

    This paper presents an experimental flexible Field Programmable Gate Array (FPGA) based platform for testing and verifying digital controlled dc-dc converters. The platform supports different types of control strategies, dc-dc converter topologies and switching frequencies. The controller platform...... interface supporting configuration and reading of setup parameters, controller status and the acquisition memory in a simple way. The FPGA based platform, provides an easy way within education or research to use different digital control strategies and different converter topologies controlled by an FPGA...

  14. Power Quality Indices Estimation Platform

    Directory of Open Access Journals (Sweden)

    Eliana I. Arango-Zuluaga

    2013-11-01

    Full Text Available An interactive platform for estimating the quality indices in single phase electric power systems is presented. It meets the IEEE 1459-2010 standard recommendations. The platform was developed in order to support teaching and research activities in electric power quality. The platform estimates the power quality indices from voltage and current signals using three different algorithms based on fast Fourier transform (FFT, wavelet packet transform (WPT and least squares method. The results show that the algorithms implemented are efficient for estimating the quality indices of the power and the platform can be used according to the objectives established. 

  15. A survey on platforms for big data analytics.

    Science.gov (United States)

    Singh, Dilpreet; Reddy, Chandan K

    The primary purpose of this paper is to provide an in-depth analysis of different platforms available for performing big data analytics. This paper surveys different hardware platforms available for big data analytics and assesses the advantages and drawbacks of each of these platforms based on various metrics such as scalability, data I/O rate, fault tolerance, real-time processing, data size supported and iterative task support. In addition to the hardware, a detailed description of the software frameworks used within each of these platforms is also discussed along with their strengths and drawbacks. Some of the critical characteristics described here can potentially aid the readers in making an informed decision about the right choice of platforms depending on their computational needs. Using a star ratings table, a rigorous qualitative comparison between different platforms is also discussed for each of the six characteristics that are critical for the algorithms of big data analytics. In order to provide more insights into the effectiveness of each of the platform in the context of big data analytics, specific implementation level details of the widely used k-means clustering algorithm on various platforms are also described in the form pseudocode.

  16. p-Fitting子群的CAP-嵌入子群%On CAP-Embedded Subgroups of p-Fitting Subgroups

    Institute of Scientific and Technical Information of China (English)

    郭鹏飞; 郭秀云

    2010-01-01

    群G的子群H称为G的CAP-嵌入子群,如果对于|H|的每个素因子p,存在G的某个CAP-子群K,使得H的某个Sylow p-子群也是K的一个Sylowp-子群.本文通过假定G的p-Fitting子群Fp(G)的某个Sylow p-子群的每个极大子群是G的CAP-嵌入子群,得到一些新的结果.

  17. Platform Performance and Challenges - using Platforms in Lego Company

    DEFF Research Database (Denmark)

    Munk, Lone; Mortensen, Niels Henrik

    2009-01-01

    This article studies the performance and challenges of using nine implemented product platforms in LEGO Company. Most of these do produce results, but do not meet their goals due to challenges in their usage in the daily product. The main challenges are that the platforms are not being used...

  18. Actin cytoskeleton: putting a CAP on actin polymerization.

    Science.gov (United States)

    Stevenson, V A; Theurkauf, W E

    2000-10-05

    Two recent studies have identified a Drosophila homolog of cyclase-associated protein (CAP) as a developmentally important negative regulator of actin polymerization that may also directly mediate signal transduction.

  19. C-CAP Land Cover, Territory of Guam 2011

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  20. 2011 C-CAP Land Cover of Oahu, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  1. C-CAP Land Cover, Big Island, Hawaii

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  2. Wind blade spar cap and method of making

    Science.gov (United States)

    Mohamed, Mansour H.

    2008-05-27

    A wind blade spar cap for strengthening a wind blade including an integral, unitary three-dimensional woven material having a first end and a second end, corresponding to a root end of the blade and a tip end of the blade, wherein the material tapers in width from the first to the second end while maintaining a constant thickness and decreasing weight therebetween, the cap being capable of being affixed to the blade for providing increased strength with controlled variation in weight from the root end to the tip end based upon the tapered width of the material thereof. The present inventions also include the method of making the wind blade spar cap and a wind blade including the wind blade spar cap.

  3. Interleukine-1-remming in cryopyrinegeassocieerd periodiek syndroom (CAPS) en schnitzlersyndroom

    NARCIS (Netherlands)

    Koning, H.D. de; Schalkwijk, J.; Meer, J.W. van der; Simon, A.

    2012-01-01

    Cryopyrin-associated periodic syndrome (CAPS) is a hereditary autoinflammatory disorder. Patients suffer from chronic systemic inflammation involving the skin (urticaria), joints arthritis) and in some cases also peritoneum (peritonitis) and meninges (meningitis). Recently, a causative mutation was

  4. The General Design and Technology Innovations of CAP1400

    Directory of Open Access Journals (Sweden)

    Mingguang Zheng

    2016-03-01

    Full Text Available The pressurized water reactor CAP1400 is one of the sixteen National Science and Technology Major Projects. Developed from China's nuclear R&D system and manufacturing capability, as well as AP1000 technology introduction and assimilation, CAP1400 is an advanced large passive nuclear power plant with independent intellectual property rights. By discussing the top design principle, main performance objectives, general parameters, safety design, and important improvements in safety, economy, and other advanced features, this paper reveals the technology innovation and competitiveness of CAP1400 as an internationally promising Gen-III PWR model. Moreover, the R&D of CAP1400 has greatly promoted China's domestic nuclear power industry from the Gen-II to the Gen-III level.

  5. C-CAP Land Cover, Kauai, Hawaii 2005

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  6. C-CAP Land Cover, Territory of Guam 2005

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of land derived from high resolution imagery and was analyzed according to the Coastal Change Analysis Program (C-CAP) protocol to determine...

  7. ATLAS - End-Cap calorimeter lowered in to the cavern

    CERN Multimedia

    2006-01-01

    The End-cap calorimeter was lowered into the ATLAS cavern at POINT1. This calorimeter will measure the energy of particles close to the beam axis when protons collide. Cooling is important for maximum detector efficiency.

  8. Download - RGP caps | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us ...atabase Description Download License Update History of This Database Site Policy | Contact Us Download - RGP caps | LSDB Archive ...

  9. Anacostia Park Data Landcover Product - NOAA C-CAP Source

    Data.gov (United States)

    National Park Service, Department of the Interior — NPScape CCAP landcover (CCAP_LAC - 1996, 2001 and 2006) and landcover change (CCAP_LCC) products. Landcover change is produced from the 1996-2001 NOAA C-CAP and...

  10. ASM LabCap's contributions to disease surveillance and the International Health Regulations (2005).

    Science.gov (United States)

    Specter, Steven; Schuermann, Lily; Hakiruwizera, Celestin; Sow, Mah-Séré Keita

    2010-12-03

    The revised International Health Regulations [IHR(2005)], which requires the Member States of the World Health Organization (WHO) to develop core capacities to detect, assess, report, and respond to public health threats, is bringing new challenges for national and international surveillance systems. As more countries move toward implementation and/or strengthening of their infectious disease surveillance programs, the strengthening of clinical microbiology laboratories becomes increasingly important because they serve as the first line responders to detect new and emerging microbial threats, re-emerging infectious diseases, the spread of antibiotic resistance, and the possibility of bioterrorism. In fact, IHR(2005) Core Capacity #8, "Laboratory", requires that laboratory services be a part of every phase of alert and response.Public health laboratories in many resource-constrained countries require financial and technical assistance to build their capacity. In recognition of this, in 2006, the American Society for Microbiology (ASM) established an International Laboratory Capacity Building Program, LabCap, housed under the ASM International Board. ASM LabCap utilizes ASM's vast resources and its membership's expertise-40,000 microbiologists worldwide-to strengthen clinical and public health laboratory systems in low and low-middle income countries. ASM LabCap's program activities align with HR(2005) by building the capability of resource-constrained countries to develop quality-assured, laboratory-based information which is critical to disease surveillance and the rapid detection of disease outbreaks, whether they stem from natural, deliberate or accidental causes.ASM LabCap helps build laboratory capacity under a cooperative agreement with the U.S. Centers for Disease Control and Prevention (CDC) and under a sub-contract with the Program for Appropriate Technology in Health (PATH) funded by the United States Agency for International Development (USAID

  11. Effect of Swim Cap Surface Roughness on Passive Drag.

    Science.gov (United States)

    Gatta, Giorgio; Cortesi, Matteo; Zamparo, Paola

    2015-11-01

    In the last decade, great attention has been given to the improvements in swimming performance that can be obtained by wearing "technical swimsuits"; the technological evolution of these materials only marginally involved swim caps production, even if several studies have pointed out the important role of the head (as main impact point with the fluid) on hydrodynamics. The aim of this study was to compare the effects on passive drag (Dp) of 3 swim cap models: a smooth silicon helmet cap (usually used during swimming competitions), a silicon helmet cap with "dimples," and a silicon helmet cap with "wrinkles." Experiments were performed on 10 swimmers who were towed underwater (at a depth of 60 cm) at 3 speeds (1.5, 1.7, and 1.9 m·s) and in 2 body positions: LA (arms above the swimmer's head) and SA (arms alongside the body). The Dp values obtained in each trial were divided by the square of the corresponding speed to obtain the speed-specific drag (the k coefficient = Dp/v). No differences in k were observed among swim caps in the LA position. No differences in k were observed between the smooth and dimpled helmets also in the SA position; however, the wrinkled swim cap helmet showed a significant larger k (4.4%) in comparison with the model with dimples, when the swimmers kept their arms alongside the body (in the SA position). These data suggest that wearing a wrinkled swim cap helmet can be detrimental to performance at least in this specific position.

  12. CARMIL is a bona fide capping protein interactant.

    Science.gov (United States)

    Remmert, Kirsten; Olszewski, Thomas E; Bowers, M Blair; Dimitrova, Mariana; Ginsburg, Ann; Hammer, John A

    2004-01-23

    CARMIL, also known as Acan 125, is a multidomain protein that was originally identified on the basis of its interaction with the Src homology 3 (SH3) domain of type I myosins from Acanthamoeba. In a subsequent study of CARMIL from Dictyostelium, pull-down assays indicated that the protein also bound capping protein and the Arp2/3 complex. Here we present biochemical evidence that Acanthamoeba CARMIL interacts tightly with capping protein. In biochemical preparations, CARMIL copurified extensively with two polypeptides that were shown by microsequencing to be the alpha- and beta-subunits of Acanthamoeba capping protein. The complex between CARMIL and capping protein, which is readily demonstratable by chemical cross-linking, can be completely dissociated by size exclusion chromatography at pH 5.4. Analytical ultracentrifugation, surface plasmon resonance and SH3 domain pull-down assays indicate that the dissociation constant of capping protein for CARMIL is approximately 0.4 microm or lower. Using CARMIL fusion proteins, the binding site for capping protein was shown to reside within the carboxyl-terminal, approximately 200 residue, proline-rich domain of CARMIL. Finally, chemical cross-linking, analytical ultracentrifugation, and rotary shadowed electron microscopy revealed that CARMIL is asymmetric and that it exists in a monomer dimer equilibrium with an association constant of 1.0 x 10(6) m(-1). Together, these results indicate that CARMIL self-associates and interacts with capping protein with affinities that, given the cellular concentrations of the proteins ( approximately 1 and 2 microm for capping protein and CARMIL, respectively), indicate that both activities should be physiologically relevant.

  13. Protein and carotenoid synthesis and turnover in gravistimulated root caps

    Science.gov (United States)

    Feldman, L. J.

    1984-01-01

    In certain cultivars of corn gravitropic bending occurs only after the root cap, the site of gravity perception, is exposed to light. Light appears to trigger or to remove some block in the gravity translation process. Using light sensitive cultivars of corn, it was shown that light affects various processes in the cap. The roles of these light-induced processes in gravitropic bending in roots were studied.

  14. Mid-small Cap Vs. Heavy-weight Share

    Institute of Scientific and Technical Information of China (English)

    Liu Xinwen

    2008-01-01

    @@ In light of the current investment trends,mid and small cap stocks are the stocks of choice for institutional capital.Currently,101 listed companies have released their performance reports.Repots show that increased stocks from 55 companies are held by institutions,some heavy-weight blue-chip stocks were sold with large margins,while some mid and small cap stocks were widely welcomed by investors.

  15. In vitro antibacterial activity of different pulp capping materials

    OpenAIRE

    Poggio, Claudio; Beltrami, Riccardo; Colombo, Marco; Ceci, Matteo; Dagna, Alberto; Chiesa, Marco

    2015-01-01

    Background Direct pulp capping involves the application of a dental material to seal communications between the exposed pulp and the oral cavity (mechanical and carious pulp exposures) in an attempt to act as a barrier, protect the dental pulp complex and preserve its vitality. The aim of this study was to evaluate and compare, by the agar disc diffusion test, the antimicrobial activity of six different pulp-capping materials: Dycal (Dentsply), Calcicur (Voco), Calcimol LC (Voco), TheraCal LC...

  16. Novel Multipin Electrode Cap System for Dry Electroencephalography.

    Science.gov (United States)

    Fiedler, P; Pedrosa, P; Griebel, S; Fonseca, C; Vaz, F; Supriyanto, E; Zanow, F; Haueisen, J

    2015-09-01

    Current usage of electroencephalography (EEG) is limited to laboratory environments. Self-application of a multichannel wet EEG caps is practically impossible, since the application of state-of-the-art wet EEG sensors requires trained laboratory staff. We propose a novel EEG cap system with multipin dry electrodes overcoming this problem. We describe the design of a novel 24-pin dry electrode made from polyurethane and coated with Ag/AgCl. A textile cap system holds 97 of these dry electrodes. An EEG study with 20 volunteers compares the 97-channel dry EEG cap with a conventional 128-channel wet EEG cap for resting state EEG, alpha activity, eye blink artifacts and checkerboard pattern reversal visual evoked potentials. All volunteers report a good cap fit and good wearing comfort. Average impedances are below 150 kΩ for 92 out of 97 dry electrodes, enabling recording with standard EEG amplifiers. No significant differences are observed between wet and dry power spectral densities for all EEG bands. No significant differences are observed between the wet and dry global field power time courses of visual evoked potentials. The 2D interpolated topographic maps show significant differences of 3.52 and 0.44% of the map areas for the N75 and N145 VEP components, respectively. For the P100 component, no significant differences are observed. Dry multipin electrodes integrated in a textile EEG cap overcome the principle limitations of wet electrodes, allow rapid application of EEG multichannel caps by non-trained persons, and thus enable new fields of application for multichannel EEG acquisition.

  17. Assessment

    Institute of Scientific and Technical Information of China (English)

    Geoff Brindley

    2005-01-01

    @@ Introduction TERMINOLOGY AND KEY CONCEPTS The term assessment refers to a variety of ways of collecting information on a learner's language ability or achievement. Although testing and assessment are often used interchangeably, the latter is an umbrella term encompassing measurement instruments administered on a ‘one-off’ basis such as tests, as well as qualitative methods of monitoring and recording student learning such as observation, simulations of project work. Assessment is also distinguished from evaluation which is concerned with the overall language programme and not just with what individual students have learnt. Proficiency assessment refers to the assessment of general language abilities acquired by the learner independent of a course of study.This kind of assessment is often done through the administration of standardised commercial language-proficency tests. On the other hand, assessment of achievement aims to establish what a student had learned in relation to a particular course or curriculum (thus frequently carried out by the teacher) .Achievement assesssment may be based either on the specific content of the course or on the course objectives (Hughes 1989).

  18. Online platforms for practising mathematics in German and English speaking countries – a systematic comparison

    OpenAIRE

    Stein, Martin

    2015-01-01

    International audience; During the last years, a multitude of web-based computer assisted systems for learning mathematics were developed. Eva-CBTM (Evaluation of Computer Based Platforms for Training in Mathematics) makes a complete survey of all such platforms (German or English as language). To do so, an evaluation scheme has been developed which assesses the help system, system structure and other features. A significant number of learning platforms will be compared using this assessment ...

  19. CARMIL is a potent capping protein antagonist: identification of a conserved CARMIL domain that inhibits the activity of capping protein and uncaps capped actin filaments.

    Science.gov (United States)

    Uruno, Takehito; Remmert, Kirsten; Hammer, John A

    2006-04-14

    Acanthamoeba CARMIL was previously shown to co-purify with capping protein (CP) and to bind pure CP. Here we show that this interaction inhibits the barbed end-capping activity of CP. Even more strikingly, this interaction drives the uncapping of actin filaments previously capped with CP. These activities are CP-specific; CARMIL does not inhibit the capping activities of either gelsolin or CapG and does not uncap gelsolin-capped filaments. Although full-length (FL) CARMIL (residues 1-1121) possesses both anti-CP activities, C-terminal fragments like glutathione S-transferase (GST)-P (940-1121) that contain the CARMIL CP binding site are at least 10 times more active. We localized the full activities of GST-P to its C-terminal 51 residues (1071-1121). This sequence contains a stretch of 25 residues that is highly conserved in CARMIL proteins from protozoa, flies, worms, and vertebrates (CARMIL Homology domain 3; CAH3). Point mutations showed that the majority of the most highly conserved residues within CAH3 are critical for the anti-CP activity of GST-AP (862-1121). Finally, we found that GST-AP binds CP approximately 20-fold more tightly than does FL-CARMIL. This observation together with the elevated activities of C-terminal fragments relative to FL-CARMIL suggests that FL-CARMIL might exist primarily in an autoinhibited state. Consistent with this idea, proteolytic cleavage of FL-CARMIL with thrombin generated an approximately 14-kDa C-terminal fragment that expresses full anti-CP activities. We propose that, after some type of physiological activation event, FL-CARMIL could function in vivo as a potent CP antagonist. Given the pivotal role that CP plays in determining the global actin phenotype of cells, our results suggest that CARMIL may play an important role in the physiological regulation of actin assembly.

  20. Response of northern winter polar cap to auroral substorms

    Science.gov (United States)

    Liou, Kan; Sotirelis, Thomas

    2016-05-01

    The three-phase substorm sequence has been generally accepted and is often tied to the Dungey cycle. Although previous studies have mostly agreed on the increase and decrease in the polar cap area during an episode of substorm, there are disparate views on when the polar cap starts to contract relative to substorm onset. Here we address this conflict using high-resolution (~1-3 min) snapshot global auroral images from the ultraviolet imager on board the Polar spacecraft. On the basis of 28 auroral substorm events, all observed in the Northern Hemispheric winter, it is found that the polar cap inflated prior to onset in all events and it attained the largest area ~6 min prior to the substorm expansion phase onset, while the dayside polar cap area remained steady around the onset. The onset of nightside polar cap deflation is found to be attributed to intensifications of aurora on the poleward edge of the nightside oval, mostly in the midnight sector. Although this result supports the loading-unloading and reconnection substorm models, it is not clear if the initial polar cap deflation and the substorm expansion are parts of the same process.

  1. Myc Regulation of mRNA Cap Methylation

    Science.gov (United States)

    Cowling, Victoria H.; Cole, Michael D.

    2010-01-01

    The c-myc proto-oncogene regulates the expression of 15% to 20% of all genes, depending on the cell type, and the regulation is usually modest (1.5- to 2.0-fold). The authors discovered that in addition to regulating mRNA abundance, c-Myc regulates the formation of the 7-methylguanosine cap on many mRNAs, including transcriptional target genes and others not transcriptionally activated. Because the 7-methylguanosine cap is required for effective translation, enhanced methyl cap formation leads to increased protein production from Myc-responsive genes that exceeds the transcriptional induction. Increased cap methylation is linked to Myc-dependent enhanced activity of 2 critical kinases, TFIIH and p-TEFb, which phosphorylate the RNA polymerase II carboxy-terminal domain (CTD). Phosphorylation of the CTD recruits RNGTT and RNMT, the enzymes involved in mRNA capping, to the nascent transcript. Evidence is accumulating that enhanced cap methylation makes a significant contribution to Myc-dependent gene regulation and protein production. PMID:21170289

  2. A decision tool for selecting trench cap designs

    Energy Technology Data Exchange (ETDEWEB)

    Paige, G.B.; Stone, J.J.; Lane, L.J. [USDA-ARS, Tucson, AZ (United States)] [and others

    1995-12-31

    A computer based prototype decision support system (PDSS) is being developed to assist the risk manager in selecting an appropriate trench cap design for waste disposal sites. The selection of the {open_quote}best{close_quote} design among feasible alternatives requires consideration of multiple and often conflicting objectives. The methodology used in the selection process consists of: selecting and parameterizing decision variables using data, simulation models, or expert opinion; selecting feasible trench cap design alternatives; ordering the decision variables and ranking the design alternatives. The decision model is based on multi-objective decision theory and uses a unique approach to order the decision variables and rank the design alternatives. Trench cap designs are evaluated based on federal regulations, hydrologic performance, cover stability and cost. Four trench cap designs, which were monitored for a four year period at Hill Air Force Base in Utah, are used to demonstrate the application of the PDSS and evaluate the results of the decision model. The results of the PDSS, using both data and simulations, illustrate the relative advantages of each of the cap designs and which cap is the {open_quotes}best{close_quotes} alternative for a given set of criteria and a particular importance order of those decision criteria.

  3. [CAP quality management system in clinical laboratory and its issue].

    Science.gov (United States)

    Tazawa, Hiromitsu

    2004-03-01

    The CAP (College of American Pathologists) was established in 1962 and, at present, CAP-accredited laboratories include about 6000 institutions all over the world, mainly in the U.S. The essential purpose of CAP accreditation is high quality reservation and improvement of clinical laboratory services for patient care, and is based on seven points, listed below. (1) Establishment of a laboratory management program and laboratory techniques to assure accuracy and improve overall quality of laboratory services. (2) Maintenance and improvement of accuracy objectively by centering on a CAP survey. (3) Thoroughness in safety and health administration. (4) Reservation of the performance of laboratory services by personnel and proficiency management. (5) Provision of appropriate information to physicians, and contribution to improved quality of patient care by close communication with physicians (improvement in patient care). (6) Reduction of running costs and personnel costs based on evidence by employing the above-mentioned criteria. (7) Reduction of laboratory error. In the future, accreditation and/or certification by organizations such as CAP, ISO, etc., may become a requirement for providing any clinical laboratory services in Japan. Taking the essence of the CAP and the characteristics of the new international standard, ISO151589, into consideration, it is important to choose the best suited accreditation and/or certification depending of the purpose of clinical laboratory.

  4. Hurricane damaged fixed platforms and wellhead structures

    Energy Technology Data Exchange (ETDEWEB)

    Shuttleworth, E.P.; Frieze, P.A.

    1998-03-01

    The objective of this study was to review data on damages to offshore platforms with a view to determining their suitability for further exploitation and analysis through a preliminary assessment of trends in the data when viewed from a risk standpoint. To realise this objective, a database on hurricane and other storm related damages was generated and past design practice, particularly concerning environmental load levels, was established. Information was gathered on extreme wave heights, damages, platform details, pushover analyses and structural frame load tests. The information was obtained through: a literature survey of journals, conference proceedings, design codes and guidelines; approaches to organisations in the offshore industry with significant experience of hurricanes, storm-damaged structures and pushover analyses; and interrogation of three major databases on offshore storm and other damages - PMB, MMS and WOAD. (author)

  5. Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay

    Directory of Open Access Journals (Sweden)

    Muhammad Nisar

    2016-03-01

    Full Text Available The fluoroquinolone antibacterial drug ciprofloxacin (cip has been used to cap metallic (silver and gold nanoparticles by a robust one pot synthetic method under optimized conditions, using NaBH4 as a mild reducing agent. Metallic nanoparticles (MNPs showed constancy against variations in pH, table salt (NaCl solution, and heat. Capping with metal ions (Ag/Au-cip has significant implications for the solubility, pharmacokinetics and bioavailability of fluoroquinolone molecules. The metallic nanoparticles were characterized by several techniques such as ultraviolet visible spectroscopy (UV, atomic force microscopy (AFM, Fourier transform infrared spectroscopy (FTIR, scanning electron microscopy (SEM and energy dispersive X-ray (EDX methods. The nanoparticles synthesized using silver and gold were subjected to energy dispersive X-ray tests in order to show their metallic composition. The NH moiety of the piperazine group capped the Ag/Au surfaces, as revealed by spectroscopic studies. The synthesized nanoparticles were also assessed for urease inhibition potential. Fascinatingly, both Ag-cip and Au-cip NPs exhibited significant urease enzyme inhibitory potential, with IC50 = 1.181 ± 0.02 µg/mL and 52.55 ± 2.3 µg/mL, compared to ciprofloxacin (IC50 = 82.95 ± 1.62 µg/mL. MNPs also exhibited significant antibacterial activity against selected bacterial strains.

  6. Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay.

    Science.gov (United States)

    Nisar, Muhammad; Khan, Shujaat Ali; Qayum, Mughal; Khan, Ajmal; Farooq, Umar; Jaafar, Hawa Z E; Zia-Ul-Haq, Muhammad; Ali, Rashid

    2016-03-25

    The fluoroquinolone antibacterial drug ciprofloxacin (cip) has been used to cap metallic (silver and gold) nanoparticles by a robust one pot synthetic method under optimized conditions, using NaBH₄ as a mild reducing agent. Metallic nanoparticles (MNPs) showed constancy against variations in pH, table salt (NaCl) solution, and heat. Capping with metal ions (Ag/Au-cip) has significant implications for the solubility, pharmacokinetics and bioavailability of fluoroquinolone molecules. The metallic nanoparticles were characterized by several techniques such as ultraviolet visible spectroscopy (UV), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) methods. The nanoparticles synthesized using silver and gold were subjected to energy dispersive X-ray tests in order to show their metallic composition. The NH moiety of the piperazine group capped the Ag/Au surfaces, as revealed by spectroscopic studies. The synthesized nanoparticles were also assessed for urease inhibition potential. Fascinatingly, both Ag-cip and Au-cip NPs exhibited significant urease enzyme inhibitory potential, with IC50 = 1.181 ± 0.02 µg/mL and 52.55 ± 2.3 µg/mL, compared to ciprofloxacin (IC50 = 82.95 ± 1.62 µg/mL). MNPs also exhibited significant antibacterial activity against selected bacterial strains.

  7. Simulating the uncertain effect of active carbon capping of a dioxin-polluted Norwegian fjord.

    Science.gov (United States)

    Starrfelt, Jostein; Saloranta, Tuomo M

    2015-07-01

    Process-based multimedia models are frequently used to simulate the long-term impacts of pollutants and to evaluate potential remediation actions that can be put in place to improve or manage polluted marine environments. Many such models are detailed enough to encapsulate the different scales and processes relevant for various contaminants, yet still are tractable enough for analysis through established methods for uncertainty assessment. Inclusion and quantification of the uncertainty associated with local efficacy of remediation actions is of importance when the desired outcome in terms of human health concerns or environmental classification shows a nonlinear relationship with remediation effort. We present an updated fugacity-based environmental fate model set up to simulate the historical fate of polychlorinated dibenzo-p-dioxins and dibenzo-furans (PCDD/Fs) in the Grenland fjords, in Norway. The model is parameterized using Bayesian inference and is then used to simulate the effect of capping parts of the polluted sediments with active carbon. Great care is taken in quantifying the uncertainty regarding the efficacy of the activated carbon cap to reduce the leaching of contaminants from the sediments. The model predicts that by capping selected parts of the fjord, biota will be classified as moderately polluted approximately a decade earlier than a natural remediation scenario. Our approach also illustrates the importance of incorporating uncertainty in local remediation efforts, as the biotic concentrations scale nonlinearly with remediation effort.

  8. Platform decisions supported by gaming

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Mikkola, Juliana Hsuan

    2007-01-01

    of these decisions can cause a high strategic risk. This paper describes and discusses the complexity of the platform decisions. We argue that new methods have to be introduced in order to create a comprehensive picture of the consequences of the platform decisions. One of the promising new methods...

  9. Preparing for a Product Platform

    DEFF Research Database (Denmark)

    Fiil-Nielsen, Ole; Munk, Lone; Mortensen, Niels Henrik

    2005-01-01

    Experience in the industry as well as recent related scientific publications show the benefits of product development platforms. Companies use platforms to develop not a single but multiple products (i.e. a product family) simultaneously. When these product development projects are coordinated...... on commonalities and similarities in the product family, and variance should be based on customer demands. To relate these terms and to improve the basis on which decisions are made, we need a way of visualizing the hierarchy of the product family as well as the commonality and variance. This visualization method...... could then be used as a tool for creating the product families, which product development platforms depend upon. Experience also tells us that one of the primary negative aspects of product developments platforms is the risk factor. When creating product development platforms companies invest a lot...

  10. ADAPTABLE ALTERNATE REALITY GAMES PLATFORM

    Directory of Open Access Journals (Sweden)

    Liviu-Adrian Cotfas

    2013-12-01

    Full Text Available In this paper, we present an alternate reality games platform that facilitates the creation of ARG projects with different themes and sizes. The platform is well integrated with the most important social media networks, thus facilitating both the involvement of the public and the creation of a more engaging interaction for the participants. A cloud-based architecture was used in order to allow the platform to easily accommodate projects of various sizes and to provide a good level of scalability. The platform is fully localizable in any language and multiple languages can be used at once to create projects that target users from different countries. An initial project that uses gamification to create an immersive learning environment has been created around the developed platform. The project combines professional and public feedback in order to provide an enhanced learning experience.

  11. 22 CFR 121.11 - Military demolition blocks and blasting caps.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Military demolition blocks and blasting caps... blasting caps. Military demolition blocks and blasting caps referred to in Category IV(a) do not include the following articles: (a) Electric squibs. (b) No. 6 and No. 8 blasting caps, including...

  12. Update History of This Database - RGP caps | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available ened. 2013/04/01 The URL of RGP caps is changed to ... http://rgp.dna.affrc.go.jp/E/publicdata/caps/index.html .... 2002/02/10 RGP caps (http://rgp.dna.affrc.go.jp/publicdata/caps/index.html) is

  13. Landscape Evolution and the Reincarnation of the Southern Residual Ice Cap

    Science.gov (United States)

    Byrne, S.; Zuber, M. T.

    2006-10-01

    Given the present rate of erosion on the southern residual ice cap, it is unlikely that any part of the cap is older than a few centuries. Unless we're lucky, why is there a residual cap present today for us to observe? We propose a solution involving constant destruction and renewal of the cap.

  14. Plat_Forms -- a contest: The web development platform comparison

    CERN Document Server

    Prechelt, Lutz

    2008-01-01

    "Plat_Forms" is a competition in which top-class teams of three programmers compete to implement the same requirements for a web-based system within 30 hours, each team using a different technology platform (Java EE, .NET, PHP, Perl, Python, or Ruby on Rails). The results will provide new insights into the real (rather than purported) pros, cons, and emergent properties of each platform. The evaluation will analyze many aspects of each solution, both external (usability, functionality, reliability, performance, etc.) and internal (structure, understandability, flexibility, etc.).

  15. Design, synthesis and biological evaluation of dinucleotide mRNA cap analog containing propargyl moiety.

    Science.gov (United States)

    Shanmugasundaram, Muthian; Charles, Irudaya; Kore, Anilkumar R

    2016-03-15

    The first example of the synthesis of new dinucleotide cap analog containing propargyl group such as m(7,3'-O-propargyl)G[5']ppp[5']G is reported. The effect of propargyl cap analog with standard cap was evaluated with respect to their capping efficiency, in vitro T7 RNA polymerase transcription efficiency, and translation activity using cultured HeLa cells. It is noteworthy that propargyl cap analog outperforms standard cap by 3.1 fold in terms of translational properties. The propargyl cap analog forms a more stable complex with translation initiation factor eIF4E based on the molecular modeling studies.

  16. Purification of capping protein using the capping protein binding site of CARMIL as an affinity matrix.

    Science.gov (United States)

    Remmert, Kirsten; Uruno, Takehito; Hammer, John A

    2009-10-01

    Capping protein (CP) is a ubiquitously expressed, heterodimeric actin binding protein that is essential for normal actin dynamics in cells. The existing methods for purifying native CP from tissues and recombinant CP from bacteria are time-consuming processes that involve numerous conventional chromatographic steps and functional assays to achieve a homogeneous preparation of the protein. Here, we report the rapid purification of Acanthamoeba CP from amoeba extracts and recombinant mouse CP from E. coli extracts using as an affinity matrix GST-fusion proteins containing the CP binding site from Acanthamoeba CARMIL and mouse CARMIL-1, respectively. This improved method for CP purification should facilitate the in vitro analysis of CP structure, function, and regulation.

  17. The transmission link of CAPS navigation and communication system

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The Chinese Area Positioning System (CAPS) is based on communication satellites with integrated capability, which is different from the Global Positioning System (GPS), the International Maritime Satellite Organization (Inmarsat) and so on. CAPS works at C-band, and its navigation information is not directly generated from the satellite, but from the master control station on the ground and transmitted to users via the satellite. The slightly inclined geostationary-satellite orbit (SIGSO) satellites are adopted in CAPS. All of these increase the difficulty in the design of the system and terminals. In this paper, the authors study the CAPS configuration parameters of the navigation master control station, information transmission capability, and the selection of the antenna aperture of the communication center station, as well as the impact of satellite parameters on the whole communication system from the perspective of the transmission link budget. The conclusion of availability of the CAPS navigation system is achieved. The results show that the CAPS inbound communication system forms a new low-data-rate satellite communication system, which can accommodate mass communication terminals with the transmission rate of no more than 1 kbps for every terminal. The communication center station should be configured with a large-aperture antenna (about 10-15 m); spread spectrum com- munication technology should be used with the spreading gain as high as about 40 dB; reduction of the satellite transponder gain attenuation is beneficial to improving the signal-to-noise ratio of the system, with the attenuation value of 0 or 2 dB as the best choice. The fact that the CAPS navigation system has been checked and accepted by the experts and the operation is stable till now clarifies the rationality of the analysis results. The fact that a variety of experiments and applications of the satellite communication system designed according to the findings in this paper have been

  18. Base resolution methylome profiling: considerations in platform selection, data preprocessing and analysis.

    Science.gov (United States)

    Sun, Zhifu; Cunningham, Julie; Slager, Susan; Kocher, Jean-Pierre

    2015-08-01

    Bisulfite treatment-based methylation microarray (mainly Illumina 450K Infinium array) and next-generation sequencing (reduced representation bisulfite sequencing, Agilent SureSelect Human Methyl-Seq, NimbleGen SeqCap Epi CpGiant or whole-genome bisulfite sequencing) are commonly used for base resolution DNA methylome research. Although multiple tools and methods have been developed and used for the data preprocessing and analysis, confusions remains for these platforms including how and whether the 450k array should be normalized; which platform should be used to better fit researchers' needs; and which statistical models would be more appropriate for differential methylation analysis. This review presents the commonly used platforms and compares the pros and cons of each in methylome profiling. We then discuss approaches to study design, data normalization, bias correction and model selection for differentially methylated individual CpGs and regions.

  19. Reliability assessment of offshore platforms exposed to wave-in-deck loading. Appendix F: Reliability analysis of offshore jacket structures with wave load on deck using the model correction factor method

    Energy Technology Data Exchange (ETDEWEB)

    Dalsgaard Soerensen, J. [Aalborg Univ., Aalborg (Denmark); Friis-Hansen, P. [Technical Univ. Denmark, Lyngby (Denmark); Bloch, A.; Svejgaard Nielsen, J. [Ramboell, Esbjerg (Denmark)

    2004-08-01

    Different simple stochastic models for failure related to pushover collapse are investigated. Next, a method is proposed to estimate the reliability of real offshore jacket structures. The method is based on the Model Correction Factor Method and can be used to very efficiently to estimate the reliability for total failure/collapse of jacket type platforms with wave in deck loads. A realistic example is evaluated and it is seen that it is possible to perform probabilistic reliability analysis for collapse of a jacket type platform using the model correction factor method. The total number of deterministic, complicated, non-linear (RONJA) analysis is typically as low as 10. Such reliability analyses are recommended to be used in practical applications, especially for cases with wave in deck load, where the traditional RSR analyses give poor measures of the structural reliability. (au)

  20. CAPS-POEIRA: um modo de intervenção no CAPS-ad

    Directory of Open Access Journals (Sweden)

    Natália Galdiano Vieira de Matos

    2011-01-01

    Full Text Available Este trabajo versa sobre el reducto de las experiencias de la investigadora conforme la voluntaria de "Capoeira Angola" en una unidad CAPS-ad. Transitando por la posición de voluntaria y psicóloga se buscó comprender la dinámica de los sujetos usuarios del servicio, además de nombrar los sentidos proporcionados por el encuentro entre el Psicoanálisis y la Capoeira Angola en los grupos operativos del CAPS-ad, siendo éste el objetivo general delineado en el trabajo. En aquel escenario, en que muchos sujetos usuarios del servicio estaban absortos a la droga, había aquellos que se interesaban por los talleres y demostraban atención a los propios tratamientos. La propuesta era comprender la dinámica observada en el grupo de sujetos drogadictos y provocar inquietudes posibles. Para eso, se intensificaba el entrelazamiento entre el Psicoanálisis, la Capoeira Angola y los grupos operativos, recursos que proporcionaban una mayor aproximación a la psique humana, el reconocimiento de la potencialidad humana de creación y de transformación de la realidad, y la comprensión de que en los grupos podría haber una re-significación de las vivencias personales y grupales. Fueron desarrollados once encuentros cuya propuesta era la articulación de los grupos con los recursos de la Capoeira Angola-musica, narrativa y movimiento. La conclusión presenta la complejidad de la problemática droga y el posible movimiento provocado en aquel grupo por medio de la Capoeira Angola, arte ancestral marcada por la resistencia en la sociedad contemporánea.