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Sample records for assessment part iii

  1. Ultrasound assessment of selected peripheral nerve pathologies. Part III: Injuries and postoperative evaluation

    Directory of Open Access Journals (Sweden)

    Berta Kowalska

    2013-03-01

    Full Text Available The previous articles of the series devoted to ultrasound diagnostics of peripheral nerves concerned the most common nerve pathologies, i.e. entrapment neuropathies. The aim of the last part of the series is to present ultrasound possibilities in the postoperative control of the peripheral nerves as well as in the diagnostics of the second most common neuropathies of peripheral nerves, i.e. posttraumatic lesions. Early diagnostics of posttraumatic changes is of fundamental importance for the course of treatment and its long-term effects. It aids surgeons in making treatment decisions (whether surgical or conservative. When surgical treatment is necessary, the surgeon, based on US findings, is able to plan a given type of operative method. In certain cases, may even abandon the corrective or reconstructive surgery of the nerve trunk (when there are extensive defects of the nerve trunks and instead, proceed with muscle transfers. Medical literature proposes a range of divisions of the kinds of peripheral nerve injuries depending on, among others, the mechanism or degree of damage. However, the most important issue in the surgeon-diagnostician communication is a detailed description of stumps of the nerve trunks, their distance and location. In the postoperative period, ultrasound is used for monitoring the operative or conservative treatment effects including the determination of the causes of a persistent or recurrent neuropathy. It facilitates decision-making concerning a repeated surgical procedure or assuming a wait-and-see attitude. It is a difficult task for a diagnostician and it requires experience, close cooperation with a clinician and knowledge concerning surgical techniques. Apart from a static assessment, a dynamic assessment of possible adhesions constitutes a crucial element of postoperative examination. This feature distinguishes ultrasound scanning from other methods used in the diagnostics of peripheral neuropathies.

  2. Google vs. the Library (Part III): Assessing the Quality of Sources Found by Undergraduates

    Science.gov (United States)

    Georgas, Helen

    2015-01-01

    This study assesses and compares the quality of sources found by undergraduate students when doing research using both Google and a library (federated) search tool. Thirty undergraduates were asked to find four sources (one book, two articles, and one additional source of their choosing) related to a selected research topic. Students used both…

  3. Drilling miniature holes, Part III

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, L.K.

    1978-07-01

    Miniature components for precision electromechanical mechanisms such as switches, timers, and actuators typically require a number of small holes. Because of the precision required, the workpiece materials, and the geometry of the parts, most of these holes must be produced by conventional drilling techniques. The use of such techniques is tedious and often requires considerable trial and error to prevent drill breakage, minimize hole mislocation and variations in hole diameter. This study of eight commercial drill designs revealed that printed circuit board drills produced better locational and size repeatability than did other drills when centerdrilling was not used. Boring holes 1 mm in dia, or less, as a general rule did not improve hole location in brass or stainless steel. Hole locations of patterns of 0.66-mm holes can be maintained within 25.4-..mu..m diametral positional tolerance if setup misalignments can be eliminated. Size tolerances of +- 3.8 ..mu..m can be maintained under some conditions when drilling flat plates. While these levels of precision are possible with existing off-the-shelf drills, they may not be practical in many cases.

  4. Neuroscience in Nazi Europe Part III

    DEFF Research Database (Denmark)

    Zeidman, Lawrence A; Kondziella, Daniel

    2012-01-01

    In Part I, neuroscience collaborators with the Nazis were discussed, and in Part II, neuroscience resistors were discussed. In Part III, we discuss the tragedy regarding european neuroscientists who became victims of the Nazi onslaught on “non-Aryan” doctors. Some of these unfortunate...... of neuroscience, we pay homage and do not allow humanity to forget, lest this dark period in history ever repeat itself....

  5. Nuclear emergency plan, Part III: Bruce

    Energy Technology Data Exchange (ETDEWEB)

    1989-01-01

    The Province of Ontario nuclear emergency plan parts I through VIII were developed pursuant to Section 8 of the Emergency Plans Act, 1983. This part III prescribes measures to be taken to deal with a nuclear emergency caused by the Bruce Nuclear Power Development. This plan deals mainly with actions at the provincial level and should be supplemented by the appropriate municipal plan from the Townships of Bruce and Kincardine and the Village of Tiverton. This document gives details on the plan data and organization and measures to be taken for internal and external notification, operations in general and for liquid emissions, and the provision of emergency information and public direction. Appendices detail response sector boundaries, alerting and lead times, outline plan and times for evacuation, the location of emergency facilities, and communications through television, radio and telephone.

  6. Nuclear Energy Center: upper St. Lawrence region. Part I. Siting. Part II. Fort Drum surrogate site, description and impact assessment. Part III. Dispersed sites impact assessment and comparison with the NEC

    Energy Technology Data Exchange (ETDEWEB)

    Merry, P.A.; Luner, C.; Hong, S.W.; Canham, H.O.; Boggs, J.F.; McCool, T.P.

    1976-12-01

    This report is one of many supporting documents used by the Nuclear Regulatory commission in the preparation of the Nuclear Energy Center Site Survey (NECSS) mandated by Congress. While the overall study focuses on the feasibility and practicability of nuclear energy centers (NECs), this report is directed towards choosing a suitable surrogate site in the upper St. Lawrence region of New York State, assessing the probable impacts associated with construction and operation of the NEC, and comparing these impacts with those associated with small dispersed nuclear power stations. The upper St. Lawrence region is surveyed to identify a specific site that might be suitable for a surrogate NEC. Several assumptions about the basic design of an NEC are delineated, and a general overview of the characteristics of the region is given. The Fort Drum Military Reservation is chosen as a suitable surrogate site. Fort Drum and the surrounding area are described in terms of land use and population patterns, terrestrial and aquatic ecology, water use and quality, meteorology, institutional framework, and socioeconomic structure. The impacts associated with NEC development are assessed. Then the impacts associated with smaller dispersed nuclear power stations located throughout New York State are assessed and compared with the impacts associated with the NEC. Finally, the impacts due to development of the transmission line networks associated with the NEC and with the dispersed power stations are assessed and compared.

  7. Introduction to Part III: Application of LCA in Practice

    DEFF Research Database (Denmark)

    Rosenbaum, Ralph K.

    2018-01-01

    While Part II of this book presents the theoretical foundation and methodology of LCA, Part III is dedicated to a comprehensive discussion of how this methodology has been adapted and applied in practice. The chapters of Part III provide an easily readable and accessible introduction to different...... fields of LCA application with their specific decision situations, user competences and stakeholder needs, and associated methodological challenges and adaptations....

  8. Searching Lexis and Westlaw: Part III.

    Science.gov (United States)

    Franklin, Carl

    1986-01-01

    This last installment in a three-part series covers several important areas in the searching of legal information: online (group) training and customer service, documentation (search manuals and other aids), account representatives, microcomputer software, and pricing. Advantages and drawbacks of both the LEXIS and WESTLAW databases are noted.…

  9. Ayurvedic literature in Urdu part-III.

    Science.gov (United States)

    Husain, S A; Bhatnagar, Vinod Kumar

    2002-01-01

    The present article is the continuation of the second part of the previous work published with the same title in the Bulletin of Indian Institute of History of medicine, Vol. XXIX. No. 2 in 1999. This work has ben initiated to introduce the books written in recent past, the period in which Urdu language had a prominent role in preserving the knowledge of old arts and sciences.

  10. Factsheets for the (eco)toxicological risk assessment strategy of the National Institute for Public Health and the Environment (RIVM), Part III

    NARCIS (Netherlands)

    Luttik R; Raaij MTM van; SEC; SIR

    2003-01-01

    Four factsheets describing risk assessment methods used at the Expert Centre for Substances (SEC) and the Centre for Substances and Integral Risk Assessment (SIR) of the National Institute for Public Health and the Environment (RIVM) are presented here with the main aim of promoting greater

  11. BETTY FREUND: A NURSE IN FRANCE - PART III

    African Journals Online (AJOL)

    BETTY FREUND: A NURSE IN FRANCE - PART III. Compiled and edited by Betty Hugo. From this date onwards most of Betty's letters were written from Cannes and since the focal point of her 'story' is her experiences as a nurse during the Great War the letters that follow will be presented as excerpts. One of the wards at ...

  12. The Universal Arrow of Time III-IV:(Part III) Nonquantum gravitation theory (Part IV) Quantum gravitation theory

    OpenAIRE

    Kupervasser, Oleg

    2011-01-01

    The paper consists of the two independent papers - the first one about Nonquantum Gravitation theory, the second one about Quantum Gravitation theory (Part III: Nonquantum Gravitation theory) The first paper is dealing with the analysis of general relativity theory (theory of gravitation) from the point of view of thermodynamic time arrow. Within this framework "informational paradox" for black holes and "paradox with the grandfather" for time travel "wormholes" are resolved. (Part IV: Quantu...

  13. Performing arts medicine - instrumentalist musicians: part III - case histories.

    Science.gov (United States)

    Dommerholt, Jan

    2010-04-01

    In parts I and II of this article series, the basic principles of examining musicians in a healthcare setting were reviewed [Dommerholt, J. Performing arts medicine - instrumentalist musicians: part I: general considerations. J. Bodyw. Mov. Ther., in press-a; Dommerholt, J. Performing arts medicine - instrumentalist musicians: part II: the examination. J. Bodyw. Mov. Ther., in press-b]. Part III describes three case reports of musicians with hand pain, interfering with their ability to play their instruments. The musicians consulted with a performing arts physiotherapist. Neither musician had a correct medical diagnosis if at all, when they first contacted the physiotherapist. Each musician required an individualized approach not only to establish the correct diagnosis, but also to develop a specific treatment program. The treatment programs included ergonomic interventions, manual therapy, trigger point therapy, and patient education. All musicians returned to playing their instruments without any residual pain or dysfunction. Copyright 2009 Elsevier Ltd. All rights reserved.

  14. An appraisal of the literature on centric relation. Part III.

    Science.gov (United States)

    Keshvad, A; Winstanley, R B

    2001-01-01

    The literature directly and indirectly related to centric relation (CR) has been reviewed chronologically. More than 300 papers and quoted sections of books have been divided into three sections. The first two parts are related to CR. Studies in this group mainly compared, either the position of the mandibular condyle or the mandible itself in different CR recordings. Various tools were discussed for this purpose. The third part of the paper is about CR-centric occlusion (CO) discrepancy. CR still remains one of the controversial issues in prosthodontics and orthodontics. Debates such as mounting casts on the articulator by reproducible records for orthodontic treatment planning and end results, and whether or not orthodontic treatment based on CO causes TMJ dysfunction, remain unsolved. The references are listed at the end of Part III.

  15. Tanzania 1895-1920 : Part III: 1914-1920s

    NARCIS (Netherlands)

    Dietz, A.J.

    2016-01-01

    An earlier version of this African Postal Heritage Paper was published as African Studies Centre Leiden Working Paper 119 / 2015: "A postal history of the First World War in Africa and its aftermath - German colonies; III Deutsch Ostafrika / German East Africa", written by Ton Dietz.

  16. Inteligencia Artificial y Neurología. (III Parte

    Directory of Open Access Journals (Sweden)

    Mario Camacho Pinto

    1987-04-01

    Full Text Available

    De acuerdo con mi anuncio esta III Parte estaría constituida por los mecanismos cerebrales susceptibles de extrapolación tal como fueron enumerados por mí: control de input-output para realizar conductas, y de inteligencia y aprendizaje, de los cuales por razón de espacio sólo se publica la mitad en esta edición de Medicina. Se trata de una presentación esquemática, auncuando ahora encuentro quizás más atractivo el enfoque de J’urgen Ruech expuesto en el Capítulo Comunicación y Psiquiatría de la obra extensa de Freedman (1 así: Input = percepción; análisis de datos = reconocimiento; procesamiento de datos = pensamiento; almacenamiento de datos = memoria; output = expresión y acción. A mi modo de ver se completaría este encuadre funcional con el tópico aprendizaje, proceso contiguo al de la memoria. Antes de entrar en materia hago unas consideraciones preliminares. En la primera me refiero a otro enfoque del concepto de LA. no incluido anteriormente. Se trata de Schank Roger y Hunter Larry (2 para quienes las indagaciones a que conduce el trasegar acerca de lA son las más atrevidas de nuestra existencia: ¿cuál es la naturaleza de la mente, qué pasa cuando estamos pensando, sintiendo, viendo o entendiendo? ¿Es posible comprender cómo trabaja nuestra mente realmente? Preguntas milenarias en cuyas respuestas no se ha registrado progreso. La lA ofrece una nueva herramienta para avanzar en este sentido: el computador.

    Las teorías sobre la mente han consistido en procesos descriptivos. Y los planteamientos iníciales hechos sobre lA por los investigadores han sido enfocados hacia lo que ellos mismos consideraron como manifestaciones de alta inteligencia: problemas matemáticos, ajedrez, rompecabezas complejos, etc.; gran cantidad de energía fue dedicada y se encontraron técnicas computacionales exitosas. Pero se comprendió que las técnicas desarrolladas no eran las mismas que emplea el cerebro, por lo cual se

  17. 46 CFR Appendix III to Part 150 - Testing Procedures for Determining Exceptions to the Chart

    Science.gov (United States)

    2010-10-01

    ... Chart III Appendix III to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Procedures for Determining Exceptions to the Chart experimental procedure for evaluating binary chemical... is joined, while the other wire of each is connected to a strip-chart recorder. The thermocouple...

  18. 40 CFR Appendix III to Part 600 - Sample Fuel Economy Label Calculation

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Sample Fuel Economy Label Calculation...) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. III Appendix III to Part 600—Sample Fuel Economy Label Calculation Suppose that a manufacturer called Mizer...

  19. PROBABILITY BASED CORROSION CONTROL FOR LIQUID WASTE TANKS - PART III

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, E.; Edwards, T.

    2010-12-09

    The liquid waste chemistry control program is designed to reduce the pitting corrosion occurrence on tank walls. The chemistry control program has been implemented, in part, by applying engineering judgment safety factors to experimental data. However, the simple application of a general safety factor can result in use of excessive corrosion inhibiting agents. The required use of excess corrosion inhibitors can be costly for tank maintenance, waste processing, and in future tank closure. It is proposed that a probability-based approach can be used to quantify the risk associated with the chemistry control program. This approach can lead to the application of tank-specific chemistry control programs reducing overall costs associated with overly conservative use of inhibitor. Furthermore, when using nitrite as an inhibitor, the current chemistry control program is based on a linear model of increased aggressive species requiring increased protective species. This linear model was primarily supported by experimental data obtained from dilute solutions with nitrate concentrations less than 0.6 M, but is used to produce the current chemistry control program up to 1.0 M nitrate. Therefore, in the nitrate space between 0.6 and 1.0 M, the current control limit is based on assumptions that the linear model developed from data in the <0.6 M region is applicable in the 0.6-1.0 M region. Due to this assumption, further investigation of the nitrate region of 0.6 M to 1.0 M has potential for significant inhibitor reduction, while maintaining the same level of corrosion risk associated with the current chemistry control program. Ongoing studies have been conducted in FY07, FY08, FY09 and FY10 to evaluate the corrosion controls at the SRS tank farm and to assess the minimum nitrite concentrations to inhibit pitting in ASTM A537 carbon steel below 1.0 molar nitrate. The experimentation from FY08 suggested a non-linear model known as the mixture/amount model could be used to predict

  20. Prerequisites for Affective Signal Processing (ASP) - Part III

    NARCIS (Netherlands)

    van den Broek, Egon; Janssen, Joris H.; van der Zwaag, Marjolein D.; Healey, Jennifer A.; Fred, A.; Filipe, J.; Gamboa, H.

    2010-01-01

    This is the third part in a series on prerequisites for affective signal processing (ASP). So far, six prerequisites were identified: validation (e.g., mapping of constructs on signals), triangulation, a physiology-driven approach, and contributions of the signal processing community (van den Broek

  1. Toward a Model of Vocational Persistence Among Seminarians: Part III

    Science.gov (United States)

    Lee, James L.

    1970-01-01

    Assumptions underlying model rely on Cartwright and Harary's (1960) definition of Heider's cognitive balance theory and Festinger's (1957) cognitive dissonance theory. Diagrams illustrate degree of balance between personal and reference group (curch authorities, classmates, family) attitudes. Parts I and II in earlier issues. (CJ)

  2. Antipsychotics and Sexual Dysfunction: Sexual Dysfunction - Part III

    Directory of Open Access Journals (Sweden)

    Anil Kumar Mysore Nagaraj

    2009-11-01

    Full Text Available Satisfying sexual experience is an essential part of a healthy and enjoyable life for most people. Antipsychotic drugs are among the various factors that affect optimal sexual functioning. Both conventional and novel antipsychotics are associated with significant sexual side effects. This review has presented various studies comparing different antipsychotic drugs. Dopamine antagonism, increased serum prolactin, serotonergic, adrenergic and cholinergic mechanisms are all proposed to be the mechanisms for sexual dysfunction. Drug treatment for this has not given satisfactory long-term results. Knowledge of the receptor pharmacology of an individual antipsychotic will help to determine whether it is more or less likely to cause sexual side effects and its management.

  3. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Science.gov (United States)

    2010-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware River...

  4. Scary gas: intravascular, intracranial, and intraspinal ectopic gas (part III).

    Science.gov (United States)

    Sandstrom, Claire K; Osman, Sherif F; Linnau, Ken F

    2017-08-01

    While ectopic gas can be a sign of dangerous disease requiring immediate medical or surgical intervention, it can also be an incidental and benign finding. Intravenous gas and spinal vacuum gas are common and almost always benign. Intravascular gas is most often related to instrumentation and, if intraarticular, can cause end-organ ischemia; however, treatment is usually supportive. Pneumocephalus arises from a communication with paranasal sinuses or mastoids more often than from meningeal infection and can usually be managed nonoperatively. In part 3 of this series, the different causes of ectopic gas in the vessels, skull, and spine are reviewed, as are the imaging features that can help to narrow the differential diagnosis.

  5. 40 CFR Table 2 to Subpart III of... - Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart III

    Science.gov (United States)

    2010-07-01

    ... Flexible Polyurethane Foam Production Pt. 63, Subpt. III, Table 2 Table 2 to Subpart III of Part 63... malfunction plan. § 63.6 (f)-(g) YES § 63.6(h) NO Subpart III does not require opacity and visible emission...

  6. Assessment of Fe(III) and Eu(III) complexation by silicate in aqueous solutions

    Science.gov (United States)

    Patten, James T.; Byrne, Robert H.

    2017-04-01

    Prior investigations of Eu3+ complexation by silicate have led to predictions that rare earth silicate complexes (REESiO(OH)32+) are the dominant species of REEs in deep waters of the Atlantic and Pacific Oceans. The proposed importance of REE-silicate complexes has been used as a foundation to explain oceanic REE profiles. In the present work, we examine the significance of rare earth element complexation by silicate ions. As one fundamental means of assessing prior depictions of REE-silicate formation constant behavior, our work examines the comparative stability constant behavior of Eu(III) and Fe(III). Plots of Eu(III) complexation constants against Fe(III) formation constants, in conjunction with experimental determinations of FeSiO(OH)32+ formation constants, indicate that previously published EuSiO(OH)32+ formation constants are substantially overestimated. Assessment of prior EuSiO(OH)32+ formation constant determinations reveals that results obtained in the presence and absence of silicic acid polymerization are inconsistent. Much larger EuSiO(OH)32+ formation constants are obtained in the presence of polymeric silica. Reanalysis of complexation results obtained under conditions of minimal silicate polymerization leads to a EuSiO(OH)32+ formation constant that is smaller than previously published estimates by as much as a factor of ∼25. The dramatically reduced magnitude of Siβ1(Eu) relative to previously published results indicates that the role of silicate complexation in oceanic REE cycling is much less significant than previously proposed. The spectrophotometric investigations of FeSiO(OH)32+ formation in the present study yield the first characterization of FeSiO(OH)32+ formation constant behavior as a function of ionic strength:

  7. Physiotherapy and low back pain - part iii: outcomes research utilising the biosychosocial model: psychosocial outcomes

    Directory of Open Access Journals (Sweden)

    L. D. Bardin

    2003-02-01

    Full Text Available A comprehensive understanding of low back pain (LBPhas evolved that necessitates the use of a biopsychosocial model, focusing on illness rather than disease and incorporating the biological, psychological and social aspects that are important to understand and to study LBP in its chronic form. Traditional outcome measures that measure elements within the biological component are limited to assess the spectrum of impacts caused by chronic low back pain (CLBP and the validity, reliability and sensitivity of some of these measures has been questioned.Few physiologic tests of spine function are clinically meaningful to patients, objective physical findings can be absent, and in CLBP disability and activity intolerance are often disproportional to the original injury. Biological outcomes should be complemented by outcomes of the psychosocial aspects of back pain that measure the considerable functional and emotional impact on the quality of life of patients experiencing low back dysfunction. Outcomes research is an analysis of clinical practice as it actually occurs and can  make a valuable contribution to understanding the multidimensional impact of LBP. Psychosocial aspects of the biopsychosocial model for outcomes research are discussed in part III: functional status/disability, psychological impairment, patient satisfaction, health related quality of life

  8. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  9. Clinical biomechanic correlates for cervical function: Part III. Intermittent secondary movements.

    Science.gov (United States)

    Vorro, J; Johnston, W L; Hubbard, R P

    1991-02-01

    Parts I and II of this study compared kinematic and myoelectric data for two groups of asymptomatic subjects classified as having symmetric or asymmetric motor response to a palpatory test for cervical sidebending. Kinematic data revealed that asymmetric subjects had limited mobility for primary and secondary motions. Myoelectric activity was slow to be initiated in the asymmetric subjects, and reduced in time and strength of contraction. Part III addresses additional specific kinematic data concerning three-dimensional orientations of the head; however, these data were accumulated throughout the paths of movement, not just at their end points as in our previous work. Although asymmetric subjects had demonstrated significantly reduced range of motion, paths of the more minor secondary axes did not differ significantly between groups. As with previous data (Part I and II), active and passive movements were undifferentiated; this degree of likeness in even minor aspects of the motor performance continues to indicate the remarkable similarities that can exist between primary movements directed and guided by trained physicians and those actively controlled by patients themselves. Part III completes a study of cervical motor behavior in which a passive gross motion test distinguished an asymmetric group with subclinical motor behavior that has measurable kinematic and myoelectric correlates.

  10. Neuroscience in Nazi Europe Part III: victims of the Third Reich.

    Science.gov (United States)

    Zeidman, Lawrence A; Kondziella, Daniel

    2012-11-01

    In Part I, neuroscience collaborators with the Nazis were discussed, and in Part II, neuroscience resistors were discussed. In Part III, we discuss the tragedy regarding european neuroscientists who became victims of the Nazi onslaught on “non-Aryan” doctors. Some of these unfortunate neuroscientists survived Nazi concentration camps, but most were murdered. We discuss the circumstances and environment which stripped these neuroscientists of their profession, then of their personal rights and freedom, and then of their lives. We include a background analysis of anti-Semitism and Nazism in their various countries, then discuss in depth seven exemplary neuroscientist Holocaust victims; including Germans Ludwig Pick, Arthur Simons, and Raphael Weichbrodt, Austrians Alexander Spitzer and Viktor Frankl, and Poles Lucja Frey and Wladyslaw Sterling. by recognizing and remembering these victims of neuroscience, we pay homage and do not allow humanity to forget, lest this dark period in history ever repeat itself.

  11. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part III - Abdominal Treatment Procedures (Long Version)

    DEFF Research Database (Denmark)

    Dietrich, Christoph F; Lorentzen, T.; Appelbaum, L.

    2016-01-01

    The third part of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Guidelines on Interventional Ultrasound (INVUS) assesses the evidence for ultrasound-guided and assisted interventions in abdominal treatment procedures. Recommendations for clinical practice...

  12. Assessing Old Order Amish outpatients with the MCMI-III.

    Science.gov (United States)

    Knabb, Joshua J; Vogt, Ronald G

    2011-05-01

    In this study, we examined Millon Clinical Multiaxial Inventory-III (MCMI-III; Millon, 2009) characteristics in an Old Order Amish outpatient sample (n = 166), with a comparison group of Old Order Amish who were not receiving mental health treatment at the time of testing (n = 80). We also graphically compared the 2 Amish groups to a non-Amish psychiatric sample in the literature. Consistent with our hypotheses, the Old Order Amish outpatients scored significantly higher than the Old Order Amish comparison group on the majority of MCMI-III scales, with mostly medium effect sizes, suggesting that the MCMI-III is a useful personality instrument in discriminating between Old Order Amish clinical and nonclinical groups. In addition, the Amish outpatients scored similar to a non-Amish psychiatric sample in the literature on most personality scales. Future MCMI-III studies with the Amish are needed to replicate and generalize our findings.

  13. Premios Nobel de Quimica y Filatelia. Parte III: polimeros, coloides, quimica aplicada, quimica inorganica y premios siglo XXI

    National Research Council Canada - National Science Library

    Martinez-Reina, Marlon; Amado-Gonzalez, Eliseo

    2014-01-01

    En Premios Nobel de Quimica y Filatelia, Parte III, se hace una revision de los sellos postales emitidos en diferentes paises para conmemorar los Premios Nobel en polimeros, coloides, quimica aplicada...

  14. A benefit-risk assessment of class III antiarrhythmic agents

    DEFF Research Database (Denmark)

    Elming, Hanne; Brendorp, Bente; Pehrson, Steen

    2004-01-01

    relief. Since many patients experience a decrease in physical performance as well as a diminished quality of life during arrhythmia there is still a need for antiarrhythmic drug therapy. The development of new antiarrhythmic agents has changed the focus from class I to class III agents since it became...... evident that with class I drug therapy the prevalence of mortality is considerably higher. This review focuses on the benefits and risks of known and newer class III antiarrhythmic agents. The benefits discussed include the ability to maintain sinus rhythm in persistent atrial fibrillation patients......, and reducing the need for implantable cardioverter defibrillator shock/antitachycardia therapy, since no class III antiarrhythmic agents have proven survival benefit. The risks discussed mainly focus on pro-arrhythmia as torsade de pointes ventricular tachycardia....

  15. Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production.

    Directory of Open Access Journals (Sweden)

    Shin Hashimoto

    Full Text Available Stress granules (SGs are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during viral infection is not fully understood. Here, we showed that mumps virus (MuV induced SGs depending on activation of protein kinase R (PKR. MuV infection strongly induced interferon (IFN-λ1, 2 and 3, and IFN-β through activation of IFN regulatory factor 3 (IRF3 via retinoic acid inducible gene-I (RIG-I and the mitochondrial antiviral signaling (MAVS pathway. MuV-induced IFNs were strongly upregulated in PKR-knockdown cells. MuV-induced SG formation was suppressed by knockdown of PKR and SG marker proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and T-cell-restricted intracellular antigen-1, and significantly increased the levels of MuV-induced IFN-λ1. However, viral titer was not altered by suppression of SG formation. PKR was required for induction of SGs by MuV infection and regulated type III IFN (IFN-λ1 mRNA stability. MuV-induced SGs partly suppressed type III IFN production by MuV; however, the limited suppression was not sufficient to inhibit MuV replication in cell culture. Our results provide insight into the relationship between SGs and IFN production induced by MuV infection.

  16. DECOVALEX III PROJECT. Thermal-Hydro-Mechanical Coupled Processes in Safety Assessments. Report of Task 4

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2005-02-15

    A part (Task 4) of the International DECOVALEX III project on coupled thermo-hydro-mechanical (T-H-M) processes focuses on T-H-M modelling applications in safety and performance assessment of deep geological nuclear waste repositories. A previous phase, DECOVALEX II, saw a need to improve such modelling. In order to address this need Task 4 of DECOVALEX III has: Analysed two major T-H-M experiments (Task 1 and Task 2) and three different Bench Mark Tests (Task 3) set-up to explore the significance of T-H-M in some potentially important safety assessment applications. Compiled and evaluated the use of T-H-M modelling in safety assessments at the time of the year 2000. Organised a forum a forum of interchange between PA-analysts and THM modelers at each DECOVALEX III workshop. Based on this information the current report discusses the findings and strives for reaching recommendations as regards good practices in addressing coupled T-H-M issues in safety assessments. The full development of T-H-M modelling is still at an early stage and it is not evident whether current codes provide the information that is required. However, although the geosphere is a system of fully coupled processes, this does not directly imply that all existing coupled mechanisms must be represented numerically. Modelling is conducted for specific purposes and the required confidence level should be considered. It is necessary to match the confidence level with the modelling objective. Coupled THM modelling has to incorporate uncertainties. These uncertainties mainly concern uncertainties in the conceptual model and uncertainty in data. Assessing data uncertainty is important when judging the need to model coupled processes. Often data uncertainty is more significant than the coupled effects. The emphasis on the need for THM modelling differs among disciplines. For geological radioactive waste disposal in crystalline and other similar hard rock formations DECOVALEX III shows it is essential to

  17. A Modified Hybrid III 6-Year-Old Dummy Head Model for Lateral Impact Assessment

    Directory of Open Access Journals (Sweden)

    I. A. Rafukka

    2016-01-01

    Full Text Available Hybrid III six-year-old (6YO child dummy head model was developed and validated for frontal impact assessment according to the specifications contained in Code of Federal Regulations, Title 49, Part 572.122, Subpart N by Livermore Software Technology Corporation (LSTC. This work is aimed at improving biofidelity of the head for frontal impact and also extending its application to lateral impact assessment by modifying the head skin viscoelastic properties and validating the head response using the scaled nine-year-old (9YO child cadaver head response recently published in the literature. The modified head model was validated for two drop heights for frontal, right, and left parietal impact locations. Peak resultant acceleration of the modified head model appeared to have good correlation with scaled 9YO child cadaver head response for frontal impact on dropping from 302 mm height and fair correlation with 12.3% difference for 151 mm drop height. Right parietal peak resultant acceleration values correlate well with scaled 9YO head experimental data for 153 mm drop height, while fair correlation with 16.4% difference was noticed for 302 mm drop height. Left parietal, however, shows low biofidelity for the two drop heights as the difference in head acceleration response was within 30%. The modified head model could therefore be used to estimate injuries in vehicle crash for head parietal impact locations which cannot be measured by the current hybrid III dummy head model.

  18. WISC-III e WAIS-III na avaliação da inteligência de cegos WISC-III/WAIS-III en ciegos WISC-III and WAIS-III in intellectual assessment of blind people

    Directory of Open Access Journals (Sweden)

    Elizabeth do Nascimento

    2007-12-01

    Full Text Available Diante da escassez de pesquisas nacionais e de testes psicológicos destinados a avaliar pessoas cegas, desenvolveu-se um estudo psicométrico com as escalas verbais dos testes WISC-III e WAIS-III. Após as adaptações de alguns estímulos e das instruções, os testes foram aplicados em crianças (N = 120 e adultos (N = 52 residentes em Belo Horizonte. Os resultados indicaram que as escalas verbais modificadas apresentam uma boa consistência interna (alfa> 0,80. Além disso, a investigação da validade fatorial identifica a presença clara de apenas um componente. Este componente explica 81% e 64% para o WISC-III e WAIS-III, respectivamente. Conclui-se que as adaptações a que se procedeu não afetaram a estrutura fatorial das escalas. Deste modo, os profissionais poderão utilizar as escalas modificadas para avaliar a inteligência de pessoas cegas.Frente a la escasez de investigaciones nacionales asi como la ausencia de tests psicológicos que evaluen personas ciegas, se ha desarrollado un estudio psicometrico com la escalas verbales del WISC-III y WAIS-III. Posteriormente a las adaptaciones de algunos estímulos y de las instrucciones, las escalas fueron aplicadas a una muestra de niños (n=120 y de adultos (n=52 residentes en la ciudad de Belo Horizonte-Brasil. Los resultados indican que las escalas verbales modificadas presentan una alta fiabilidad (alpha >0,80 asi como la presencia clara de un unico componente responsable por 81% y 64% de la variancia del WIC-III e WAIS-III respectivamente. Se ha concluido que las modificaciones efectuadas no han comprometido la estructura factorial de las escalas verbales. Por tanto, los profesionales psicólogos pueden utilizar las escalas modificadas para la evaluación de la inteligencia de personas portadoras de ceguera.Owing to the almost lack of a national research on psychological testing for the evaluation of blind people, a psychometric study has been developed with the WISC-III and WAIS-III

  19. Mid-Term Assessment of the activties of Fadama III development ...

    African Journals Online (AJOL)

    This paper assessed the activities of Fadama III project in Cross River State. It viewed the aim, objectives, achievements, perceptions of beneficiaries and challenges of the project in the state. It was discovered that Fadama III is aimed at increasing the income of rural land and water resource users, reduce rural poverty, ...

  20. A Study of Low-Wage Workers and Their Response to High Intensity Training. Volume III, Part 1 and Part 2: Appendices B 1-5.

    Science.gov (United States)

    Davis, Earl E.

    This document is the last of a three-volume study designed to examine low-wage, low-skilled workers, within the context of their work environment, and to develop ways of measuring the effects of skill advancement training upon the program participants. Volume III, Parts I and II, contains modified employee pre- and post-test interview schedules…

  1. A benefit-risk assessment of class III antiarrhythmic agents

    DEFF Research Database (Denmark)

    Brendorp, Bente; Pedersen, Oledyg; Torp-Pedersen, Christian

    2002-01-01

    With beta-blockers as the exception, increasing doubt is emerging on the value of antiarrhythmic drug therapy following a series of trials that have either shown no mortality benefit or even an excess mortality. Vaughan Williams class I drugs are generally avoided in patients with structural heart...... prevention of ventricular arrhythmias and in treatment of atrial fibrillation or flutter. Based on existing evidence there is no routine indication for antiarrhythmic drug therapy other than beta-blockers in patients at high risk of sudden death. Subgroup analyses of trials with amiodarone and dofetilide......-intervals or - in the future - from genetic testing. Class III drugs are effective in converting atrial fibrillation to sinus rhythm and for the maintenance of sinus rhythm after conversion. This is currently by far the most important indication for this class of drugs. As defined by recent guidelines, amiodarone...

  2. Socioeconomic Impact Assessment: Communications Industry. Phase III. Technology Forecast.

    Science.gov (United States)

    1979-02-02

    attempt to label each part as a phoneme or at least with selected features (such as whether it is a vowel or consonant). The machine then proceeds to a...of speech sounds (the easiest to reproduce), variability in pronunciations , stress and intonation4 patterns, sound patterns of words, grammatical

  3. Assessing the success probability of a Phase III clinical trial based on Phase II data.

    Science.gov (United States)

    Su, Zheng

    2010-11-01

    Assessing the probability that a Phase III clinical trial will demonstrate clinically relevant efficacy based on Phase II data is an important topic in clinical drug development. An accurate estimate of how likely a Phase III trial will succeed based on available data will inform the decision on whether to move an experimental medicine forward to Phase III testing. Bayesian and likelihood methodologies have been developed in the literature to assess the probability of reproducibility in clinical trials for parametric models. A class of approaches that combines the Bayesian and likelihood approaches is proposed to evaluate the success probability of a Phase III trial based on Phase II data, which applies to the parametric, semi-parametric, and non-parametric settings and includes the Bayesian and likelihood approaches as special cases. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. MORTALITY RISK ASSESSMENT IN PICU USING PRISM-III-24 SCORE

    OpenAIRE

    Harilal Naik; Shrikant; Sharanagouda; Sharan

    2014-01-01

    OBJECTIVE: Assessment of risk of mortality using PRISM III-24 score in children admitted to PICU of Basaweshwara Teaching and General Hospital, attached to Mahadevappa Rampure Medical College, Gulbarga. DESIGN: Prospective cohort study. Setting: PICU of BTGH, Gulbarga. METHODS: 404 patients who had been admitted consecutively to the PICU during a period of 12 months (July 2011 to June 2012) were studied. PRISM III-24 score was calculated. Hospital outcome was recorded as s...

  5. 78 FR 78349 - Andrew Peklo III; Notice of Availability of Draft Environmental Assessment

    Science.gov (United States)

    2013-12-26

    ... Energy Regulatory Commission Andrew Peklo III; Notice of Availability of Draft Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and ] the Federal Energy Regulatory... a draft Environmental Assessment (EA). The draft EA contains the staff's analysis of the potential...

  6. Collisions of Small Drops in a Turbulent Flow. Part III: Relative Droplet Fluxes and Swept Volumes.

    Science.gov (United States)

    Pinsky, M. B.; Khain, A. P.; Grits, B.; Shapiro, M.

    2006-08-01

    Swept volumes of cloud droplets with radii below 20 μm are calculated under conditions typical of atmospheric cloud turbulence characterized by enormous values of Reynolds numbers, high turbulent intermittency, and characteristic values of the dissipation rate. To perform the calculations, the motion equation for small droplets proposed by Maxey is generalized for Stokes numbers St > 0.1, which allows one to simulate relative droplet motion even for very high turbulence intensities typical of deep cumulus clouds. Analytical considerations show that droplet motion is fully determined by turbulent shears and the Lagrangian accelerations.A new statistical representation of a turbulent flow has been proposed based on the results of the scale analysis of turbulence characteristics and those related to the droplet motion. According to the method proposed, statistical properties of turbulent flow are represented by a set of noncorrelated samples of turbulent shears and Lagrangian accelerations. Each sample can be assigned to a certain point of the turbulent flow. Each such point can be surrounded by a small “elementary” volume with linear length scales of the Kolmogorov length scale, in which the Lagrangian acceleration and turbulent shears can be considered as uniform in space and invariable in time.This present study (Part III) investigates the droplet collisions in a turbulent flow when hydrodynamic droplet interaction (HDI) is disregarded. Using a statistical model, long series of turbulent shears and accelerations were generated, reproducing probability distribution functions (PDF) at high Reynolds numbers, as they were obtained in recent laboratory and theoretical studies. Swept volumes of droplets are calculated for each sample of an acceleration shear pair, and the PDF of swept volumes is calculated for turbulent parameters typical of cloud turbulence. The effect of turbulent flow intermittency manifests itself in two aspects: 1) an increase of swept volume

  7. Model assessment of protective barriers: Part 3

    Energy Technology Data Exchange (ETDEWEB)

    Fayer, M.J.; Rockhold, M.L.; Holford, D.J.

    1992-02-01

    Radioactive waste exists at the US Department of Energy's (DOE's) Hanford Site in a variety of locations, including subsurface grout and tank farms, solid waste burial grounds, and contaminated soil sites. Some of these waste sites may need to be isolated from percolating water to minimize the potential for transport of the waste to the ground water, which eventually discharges to the Columbia River. Multilayer protective barriers have been proposed as a means of limiting the flow of water through the waste sites (DOE 1987). A multiyear research program (managed jointly by Pacific Northwest Laboratory (PNL) and Westinghouse Hanford Company for the DOE) is aimed at assessing the performance of these barriers. One aspect of this program involves the use of computer models to predict barrier performance. Three modeling studies have already been conducted and a test plan was produced. The simulation work reported here was conducted by PNL and extends the previous modeling work. The purpose of this report are to understand phenomena that have been observed in the field and to provide information that can be used to improve hydrologic modeling of the protective barrier. An improved modeling capability results in better estimates of barrier performance. Better estimates can be used to improve the design of barriers and the assessment of their long-term performance.

  8. [Magnetic resonance imaging assessment of the lateral pterygoid muscle in Class III malocclusion subjects].

    Science.gov (United States)

    Liu, Yue-hua; Yang, Xiao-jiang; Gao, Xiao-hui; Li, Yuan

    2012-01-01

    To analyze the relationship between Class III malocclusion and pathological changes in temporomandibular joint (TMJ) structures using magnetic resenonce imaging (MRI). Twenty-four Class III malocclusion adult patients and 10 normal control cases were included in the study. The characteristics of lateral pertygoid muscle (LPM) in the sample group and the control group were assessed. More pathological changes of LPM were found in Class III malocclusion adult patients (36 TMJ). The changes included hypertrophy, atrophy and contracture. And there was no relation between the pathological changes of LPM and the symptom of temporomandibular disorders (TMD). The frequency of pathological changes of LPM was greater in patients with Class III malocclusion than in the control group.

  9. Introduction to economic assessment - part 2.

    Science.gov (United States)

    McMahon, Ann; Sin, Chih Hoong

    2014-07-01

    This is the second in a series of four continuing professional development articles that explain some of the principles of economic assessment (EA) and describe how they may be applied in practice by front line practitioners leading service innovations. It introduces a methodology, with associated tools and templates, that has been used by practising nurses to conduct EAs. Our purpose is to equip readers with the knowledge to develop a technically competent, pragmatic EA that will contribute towards evidence-informed decision making and assure the best use of limited resources. If you have not already read the first article in this series ( McMahon and Sin 2013), we strongly advise you to do so as each article purposefully draws and builds on those that have gone before. The time out exercises in the first article required you to access source material located on the RCN website and identify a service innovation in your workplace. The time out exercises in this article draw in these same sources. We begin this article by recapping on the points covered in the first article before exploring the implications of the principles of EA and how to apply them in practice. In this article, we refer to and draw on a companion article published in this edition of Nursing Management ( pages 38-41) that sets out the most commonly cited approaches to EA in health and social care. We aim to enable readers, along with those they seek to influence, to make an informed decision as to what may be an appropriate EA approach in any specific context.

  10. Providing for energy efficiency in homes and small buildings. Part III. Determining which practices are most effective and installing materials

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-06-01

    The training program is designed to educate students and individuals in the importance of conserving energy and to provide for developing skills needed in the application of energy-saving techniques that result in energy-efficient buildings. A teacher guide and student workbook are available to supplement the basic manual. Subjects covered in Part III are: determining which practices are most efficient and economical; installing energy-saving materials; and improving efficiency of equipment.

  11. Characteristics of Limited English Proficient Hispanic Students Served in Programs for the Speech and Language Handicapped: Implications for Policy, Practice and Research. Part III.

    Science.gov (United States)

    Ortiz, Alba A.; And Others

    This document is Part III of a research study examining special education service delivery for limited English proficient (LEP) Hispanic students who have been placed in programs for the learning-disabled, speech handicapped, and mentally retarded. The objectives of Part III of this study were: (1) identify the characteristics of Hispanic students…

  12. Field Surveys, IOC Valleys. Volume III, Part I. Cultural Resources Survey, Dry Lake Valley, Nevada.

    Science.gov (United States)

    1981-08-01

    Delmues (or Swiss Bob) Well where there was a station, then west across Dry Lake Valley toward Coyote Spring to another station (Lloyd, 1980). The line...in the recorded surface assemblages of the temporary camps. Further investigations may $ Etag E-TR-48-III-I 120 clarify the specific nature of the

  13. Water Ingestion into Axial Flow Compressors. Part III. Experimental Results and Discussion

    Science.gov (United States)

    1981-10-01

    specifications, or other data, is not to be re- garded by implication or otherwise as in any manner licensing the holder or any other person or corporation , or...arises a large change In gas phase and liquid phase (a) mass flow and (b) temperatura and also a change in gas phase composition. In regime (iii) one

  14. A systematic review of the Indo-Australian Zosteropidae (Part III)

    NARCIS (Netherlands)

    Mees, G.F.

    1969-01-01

    CONTENTS Introduction .................. 4 Acknowledgements................. 5 Systematic part.................. 7 Zosterops (concluded)................ 7 Tephrozosterops................. 167 Madanga................... 169 Lophozosterops................. 171 Oculocincta.................. 204

  15. Intraosseous carcinoma of the jaws: A clinicopathologic review. Part III: Primary intraosseous squamous cell carcinoma

    NARCIS (Netherlands)

    Woolgar, J.A.; Triantafyllou, A.; Ferlito, A.; Devaney, K.O.; Lewis Jr., J.S.; Rinaldo, A.; Slootweg, P.J.; Barnes, L.

    2013-01-01

    This is the third part of a review of the clinicopathologic features of intraosseous carcinoma of the jaws (IOCJ). In parts 1 and 2, we discussed metastatic and salivary-type and odontogenic carcinomas, respectively. This part deals with primary intraosseous squamous cell carcinoma. Again, based on

  16. A Review & Assessment of Current Operating Conditions Allowable Stresses in ASME Section III Subsection NH

    Energy Technology Data Exchange (ETDEWEB)

    R. W. Swindeman

    2009-12-14

    The current operating condition allowable stresses provided in ASME Section III, Subsection NH were reviewed for consistency with the criteria used to establish the stress allowables and with the allowable stresses provided in ASME Section II, Part D. It was found that the S{sub o} values in ASME III-NH were consistent with the S values in ASME IID for the five materials of interest. However, it was found that 0.80 S{sub r} was less than S{sub o} for some temperatures for four of the materials. Only values for alloy 800H appeared to be consistent with the criteria on which S{sub o} values are established. With the intent of undertaking a more detailed evaluation of issues related to the allowable stresses in ASME III-NH, the availabilities of databases for the five materials were reviewed and augmented databases were assembled.

  17. Validating the Conceptions of Assessment-III Scale in Canadian Preservice Teachers

    Science.gov (United States)

    Daniels, Lia M.; Poth, Cheryl; Papile, Chiara; Hutchison, Marnie

    2014-01-01

    The purpose of this study was to test the validity of the Teachers' Conceptions of Assessment Scale III-Abridged Version (CoA-IIIA; Brown, 2006), a measure created, validated, and applied outside of North America, in a sample of Canadian preservice teachers (n = 436). This work is important because although we have long known that teachers'…

  18. Applicability of WaveWatch-III wave model to fatigue assessment of offshore floating structures

    NARCIS (Netherlands)

    Zou, T.; Kaminski, M.L.

    2016-01-01

    In design and operation of floating offshore structures, one has to avoid fatigue failures caused by action of ocean waves. The aim of this paper is to investigate the applicability of WaveWatch-III wave model to fatigue assessment of offshore floating structures. The applicability was investigated

  19. AICRG, Part III: The influence of antibiotic use on the survival of a new implant design.

    Science.gov (United States)

    Morris, Harold F; Ochi, Shigeru; Plezia, Richard; Gilbert, Harry; Dent, C Daniel; Pikulski, James; Lambert, Paul M

    2004-01-01

    The American College of Surgeons guidelines suggest that complex oral surgery may benefit from prophylactic antibiotic coverage. The use of preoperative antibiotics, postoperative antibiotics, or both during implant placement is a widely accepted practice in the United States, whereas dentists in other countries rarely use antibiotics. The purpose of this study was to determine if antibiotic coverage at the time of implant placement improves the survival of the Ankylos implant. As part of a comprehensive, multicentered, multidisciplinary, prospective, independent, international clinical study, designed and coordinated in the United States by the Ankylos Implant Clinical Research Group (AICRG), the use of preoperative (several regimens) and postoperative antibiotics (yes/no) were carefully documented to assess their influence on improving survival. A total of 1500 Ankylos implants were placed and followed for a period of 3 to 5 years. The decision to use antibiotics and the regimen to be employed was made by the treating surgeon. Failure was defined as removal of the implant for any reason. All data were entered into a computerized database for analysis. The use of preoperative antibiotics produced no significant improvement (P = .21, Fisher's exact test) in survival compared with those placed without antibiotic coverage. There was no significant difference between the regimens defined as AHA-1990, AHA-1997, and Peterson's recommendations. The results of this study suggest that there was little or no advantage to providing antibiotic coverage when placing this implant. These findings also suggest that the use of antibiotics for implant placement may not be as beneficial as once believed. If validated by other studies, the elimination of this practice for routine implant placement would represent a small but significant step forward in the reduction of unnecessary antibiotic use.

  20. A micromachined capacitive incremental position sensor: part 2. experimental assessment

    NARCIS (Netherlands)

    Kuijpers, A.A.; Krijnen, Gijsbertus J.M.; Wiegerink, Remco J.; Lammerink, Theodorus S.J.; Elwenspoek, Michael Curt

    2006-01-01

    Part 2 of this two-part paper presents the experimental assessment of a micromachined capacitive incremental position sensor for nanopositioning of microactuator systems with a displacement range of 100 μm or more. Incremental sensing in combination with quadrature detection reduces the requirements

  1. Assessing DSM-5 section III personality traits and disorders with the MMPI-2-RF.

    Science.gov (United States)

    Sellbom, Martin; Anderson, Jaime L; Bagby, R Michael

    2013-12-01

    An alternative model for diagnosing personality disorders (PDs) appears in DSM-5 Section III. This model includes a set of dimensional personality traits, which along with impairment in personality functioning can be configured to represent one of six PDs. Although specific assessment instruments for these personality traits have already been developed (e.g., the Personality Inventory for DSM-5 [PID-5]), clinicians will likely continue to use omnibus measures of psychopathology that are familiar to them to inform diagnostic decision making. One such measure, the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), will likely remain in the test armamentarium of many practitioners and be employed to assess the DSM-5 dimensional traits. In the current investigation, we examined the associations between MMPI-2-RF scale scores and the PID-5 trait scores and DSM-5 Section III PDs in a combined sample of university students (n = 668) from the United States and Canada. Our results indicated that the MMPI-2-RF scale scores mostly converge with PID-5 dimensional traits as well as the Section III PDs in a conceptually expected manner. As such, we conclude that the MMPI-2-RF is a potentially useful instrument in assessing personality psychopathology as conceptualized in DSM-5 Section III.

  2. Assessment of Euroscore and SAPS III as hospital mortality predicted in cardiac surgery.

    Science.gov (United States)

    Mateos-Pañero, B; Sánchez-Casado, M; Castaño-Moreira, B; Paredes-Astillero, I; López-Almodóvar, L F; Bustos-Molina, F

    2017-05-01

    To perform an external validation of Euroscore I, Euroscore II and SAPS III. Retrospective cohort study over three years on all adult patients who underwent cardiac surgery. We reviewed the clinical data, following the patient until outcome or discharge from hospital (dead, alive). We computed the predicted mortality by Euroscore I (EI), II (EII) and SAPS III. The model validation was assessed by discrimination: area under curve ROC; and calibration (Hosmer-Lemeshow test). 866 patients were included. 62.5% of them male, with a median age of 69 years, 6.1% died during hospitalization. Predicted mortality: E I 7.94%, E II 3.54, SAPS III 12.1%. Area under curve (95% IC): E I 0.862 (0.812-0.912); E II 0.861 (0.806-0.915); SAPS III 0.692 (0.601-0.784). Hosmer-Lemeshow test: E I 14.0046 (P=.08164); E II 33.67 (P=.00004660); SAPS III 11.57 (P=.171). EII had good discrimination, but the calibration was not good with predicted mortality lower than the real mortality. E I showed the best discrimination with good calibration and a tendency to overestimate the mortality. SAPS III showed poor discrimination with good calibration and a tendency to greatly overestimate the predicted mortality. We saw no improvement in the predictive performance of EII over I and we reject the use of SAPS III in this kind of patient. Copyright © 2017 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  3. Assessment of Upper and Lower Pharyngeal Airway Width in Skeletal Class I, II and III Malocclusions

    Directory of Open Access Journals (Sweden)

    Shalu Jain

    2014-01-01

    Full Text Available Introduction: There is a close relationship between the dimensions of airway and the sagittal skeletal malocclusion which makes it reasonable to expect that width of airway is a reflection of determining patency of airway in different skeletal malocclusion groups. So, aim of this study was to assess the upper and lower pharyngeal airway width in skeletal Class I, II and III malocclusion groups and also to evaluate sexual dimorphism in western Uttar Pradesh population. Materials and methods: A sample of 150 subjects in the age group of 18 to 25 years, from Western Uttar Pradesh adult population was selected on the basis of skeletal Class I, II and III malocclusion. Digital lateral cephalograms were taken in natural head position. Nine variables were selected which included four upper and five lower pharyngeal airway variables. Results: Upper and lower pharynx showed statistical significant difference among the skeletal Class I, II and III malocclusion and also between males and females. Conclusion: Wider upper and lower pharyngeal airway width was seen in males than in females in both skeletal Class I as well as Class III malocclusion groups respectively. Skeletal Class III malocclusion subjects had the widest airway width as compared to skeletal Class I malocclusion group. Skeletal Class II malocclusion, airway width was found to be narrowest.

  4. PIO I-II tendencies. Part 2. Improving the pilot modeling

    Directory of Open Access Journals (Sweden)

    Ioan URSU

    2011-03-01

    Full Text Available The study is conceived in two parts and aims to get some contributions to the problem ofPIO aircraft susceptibility analysis. Part I, previously published in this journal, highlighted the mainsteps of deriving a complex model of human pilot. The current Part II of the paper considers a properprocedure of the human pilot mathematical model synthesis in order to analyze PIO II typesusceptibility of a VTOL-type aircraft, related to the presence of position and rate-limited actuator.The mathematical tools are those of semi global stability theory developed in recent works.

  5. Taxonomic classification of phytoplankton with multivariate optical computing, part III: demonstration.

    Science.gov (United States)

    Pearl, Megan R; Swanstrom, Joseph A; Bruckman, Laura S; Richardson, Tammi L; Shaw, Timothy J; Sosik, Heidi M; Myrick, Michael L

    2013-06-01

    We describe the automatic analysis of fluorescence tracks of phytoplankton recorded with a fluorescence imaging photometer. The optical components and construction of the photometer were described in Part I and Part II of this series in this issue. An algorithm first isolates tracks corresponding to a single phytoplankter transit in the nominal focal plane of a flow cell. Then, the fluorescence streaks in the track that correspond to individual optical elements on the filter wheel are identified. The fluorescence intensity of each streak is integrated and used to calculate ratios. This approach was tested using 853 fluorescence measurements of the coccolithophore Emiliania huxleyi and the diatom Thalassiosira pseudonana. Average intensity ratios for the two classes closely follow those predicted in Part I of this series, with a distribution of ratios in each class that is consistent with the signal-to-noise ratio calculations in Part II for single cells. No overlap of the two class ratios was observed, yielding perfect classification.

  6. The Marine Mollusca of Suriname (Dutch Guiana) Holocene and recent Part III. Gastropoda and Cephalopoda

    NARCIS (Netherlands)

    Regteren Altena, van C.O.

    1975-01-01

    CONTENTS 1. Introduction, systematic survey and page references....... 3 2. Gastropoda and Cephalopoda............. 8 3. List of corrections of and additions to Part II......... 89 4. References.................. 92 5. Plates ................... 100 1. INTRODUCTION, SYSTEMATIC SURVEY AND PAGE

  7. Imaging assessment of isolated lesions affecting cranial nerve III; Avaliacao por imagem das lesoes isoladas do III par craniano

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, Marcelo de Mattos [Colegio Brasileiro de Radiologia e Diagnostico por Imagem (CBR), Sao Paulo, SP (Brazil)]. E-mail: cidbh@cidbh.com.br; Martins, Jose Carlos Tadeu [Sociedade Brasileira de Neuroradiologia, Sao Paulo, SP (Brazil)

    2005-05-15

    The aim of this study is to review the anatomy and main pathologic conditions affecting cranial nerve III using imaging studies, particularly magnetic resonance imaging. Imaging methods are essential in the evaluation of patients with suspected lesions of the oculomotor nerve once signs and symptoms are unspecific and a large number of diseases can affect cranial nerve III. A brief review of the literature is also presented. (author)

  8. Improving Hybrid III injury assessment in steering wheel rim to chest impacts using responses from finite element Hybrid III and human body model.

    Science.gov (United States)

    Holmqvist, Kristian; Davidsson, Johan; Mendoza-Vazquez, Manuel; Rundberget, Peter; Svensson, Mats Y; Thorn, Stefan; Törnvall, Fredrik

    2014-01-01

    The main aim of this study was to improve the quality of injury risk assessments in steering wheel rim to chest impacts when using the Hybrid III crash test dummy in frontal heavy goods vehicle (HGV) collision tests. Correction factors for chest injury criteria were calculated as the model chest injury parameter ratios between finite element (FE) Hybrid III, evaluated in relevant load cases, and the Total Human Model for Safety (THUMS). This is proposed to be used to compensate Hybrid III measurements in crash tests where steering wheel rim to chest impacts occur. The study was conducted in an FE environment using an FE-Hybrid III model and the THUMS. Two impactor shapes were used, a circular hub and a long, thin horizontal bar. Chest impacts at velocities ranging from 3.0 to 6.0 m/s were simulated at 3 impact height levels. A ratio between FE-Hybrid III and THUMS chest injury parameters, maximum chest compression C max, and maximum viscous criterion VC max, were calculated for the different chest impact conditions to form a set of correction factors. The definition of the correction factor is based on the assumption that the response from a circular hub impact to the middle of the chest is well characterized and that injury risk measures are independent of impact height. The current limits for these chest injury criteria were used as a basis to develop correction factors that compensate for the limitations in biofidelity of the Hybrid III in steering wheel rim to chest impacts. The hub and bar impactors produced considerably higher C max and VC max responses in the THUMS compared to the FE-Hybrid III. The correction factor for the responses of the FE-Hybrid III showed that the criteria responses for the bar impactor were consistently overestimated. Ratios based on Hybrid III and THUMS responses provided correction factors for the Hybrid III responses ranging from 0.84 to 0.93. These factors can be used to estimate C max and VC max values when the Hybrid III is

  9. Electre III method in assessment of variants of integrated urban public transport system in Cracow

    Directory of Open Access Journals (Sweden)

    Katarzyna SOLECKA

    2014-12-01

    Full Text Available There is a lot of methods which are currently used for assessment of urban public transport system development and operation e.g. economic analysis, mostly Cost-Benefit Analysis – CBA, Cost-Effectiveness Analysis - CEA, hybrid methods, measurement methods (survey e.g. among passengers and measurement of traffic volume, vehicles capacity etc., and multicriteria decision aiding methods (multicriteria analysis. The main aim of multicriteria analysis is the choice of the most desirable solution from among alternative variants according to different criteria which are difficult to compare against one another. There are several multicriteria methods for assessment of urban public transport system development and operation, e.g. AHP, ANP, Electre, Promethee, Oreste. The paper presents an application of one of the most popular variant ranking methods – Electre III method. The algorithm of Electre III method usage is presented in detail and then its application for assessment of variants of urban public transport system integration in Cracow is shown. The final ranking of eight variants of integration of urban public transport system in Cracow (from the best to the worst variant was drawn up with the application of the Electre III method. For assessment purposes 10 criteria were adopted: economical, technical, environmental, and social; they form a consistent criteria family. The problem was analyzed with taking into account different points of view: city authorities, public transport operators, city units responsible for transport management, passengers and others users. Separate models of preferences for all stakeholders were created.

  10. Essentials of WJ III[TM] Tests of Achievement Assessment. Essentials of Psychological Assessment Series.

    Science.gov (United States)

    Mather, Nancy; Wendling, Barbara J.; Woodcock, Richard W.

    The widely used Woodcock Johnson (WJ) Test of Achievement has been separated into two distinct tests, Achievement and Cognitive Abilities. This book is designed to help busy mental health professionals acquire the knowledge and skills they need to use the third revision of the WJ Tests of Achievement (WJ III ACH) , including administration,…

  11. Antibacterianos de acción sistémica: Parte III. Sulfonamidas y tetraciclinas

    Directory of Open Access Journals (Sweden)

    Manuel Cué Brugueras

    1999-04-01

    Full Text Available Resumen: Se presenta la tercera parte de una revisión bibliográfica sobre los antibacterianos de elección, en la cual se abordan los grupos sulfonamidas y tetraciclinas; además, se incluye un cuadro resumen con los antibióticos tratados en las tres partes, así como sus vías de administración y nombres comerciales que se utilizan en Cuba. Se hacen algunas consideraciones sobre la manera de enfrentar la gran variedad de antibióticos y el costo de la antibióticoterapia por parte de los países en vías de desarrollo, tomando como referencia algunas recomendaciones hechas por la OPS/OMSSummary: The third part of a bibliographic review on the elective antibacterials in which the groups of sulfonamides and tetracyclines are approached is presented. It is also included a summary picture with the antibiotics dealt with in the three parts, the routes of administration, and the trade names used in Cuba. Some considerations are made on the way to face the wide range of antibiotics and the cost of antibiotic therapy in the developing countries, taking into account some recommendations made by the PAHO/WHO

  12. Collision Avoidance "Short Course" Part III: CA Role in Changing Space Flight Environment

    Science.gov (United States)

    Newman, Lauri

    2017-01-01

    Satellite conjunction assessment is perhaps the fastest-growing area in space situational awareness and protection, with military, civil, and commercial satellite owner operators embracing more and more sophisticated processes to avoid the avoidable namely collisions between high-value space assets and orbital debris. NASA and CNES have collaborated to offer an introductory short course on all the major aspects of the conjunction assessment problem. This half-day course will cover satellite conjunction dynamics and theory, JSpOC conjunction data products, major risk assessment parameters and plots, conjunction remediation decision support, and present and future challenges. This briefing represents the NASA portion of the course.

  13. LEXICOGRAPHY. HISTORY OF ENGLISH, PART ONE. LANGUAGE CURRICULUM III, STUDENT VERSION.

    Science.gov (United States)

    KITZHABER, ALBERT R.

    AN OUTLINE OF THE NEED FOR AND USES OF LEXICOGRAPHY AND A HISTORY OF THE ENGLISH LANGUAGE, PART 1, WERE COMBINED IN THIS CURRICULUM GUIDE FOR NINTH-GRADE STUDENTS. THE FIRST SECTION, THE OUTLINE ON LEXICOGRAPHY, GAVE A BRIEF HISTORY OF DICTIONARY COMPILATION AND DESCRIBED THE NEED FOR DICTIONARIES AND THEIR USES. WAYS WERE SUGGESTED FOR STUDENTS…

  14. The energy balance experiment EBEX-2000. Part III: Behaviour and quality of the radiation measurements

    NARCIS (Netherlands)

    Kohsiek, W.; Liebethal, C.; Foken, T.; Vogt, R.; Oncley, S.P.; Bernhofer, C.; Debruin, H.A.R.

    2007-01-01

    An important part of the Energy Balance Experiment (EBEX-2000) was the measurement of the net radiation and its components. Since the terrain, an irrigated cotton field, could not be considered homogeneous, radiation measurements were made at nine sites using a variety of radiation instruments,

  15. French RSE-M and RCC-MR code appendices for flaw analysis: Presentation of the fracture parameters calculation-Part III: Cracked pipes

    Energy Technology Data Exchange (ETDEWEB)

    Marie, S. [CEA Saclay, DEN/DM2S/SEMT/LISN, 91191 Gif sur Yvette Cedex (France)], E-mail: stephane.marie@cea.fr; Chapuliot, S.; Kayser, Y. [CEA Saclay, DEN/DM2S/SEMT/LISN, 91191 Gif sur Yvette Cedex (France); Lacire, M.H. [CEA Saclay, DEN/DDIN, 91191 Gif sur Yvette Cedex (France); Drubay, B. [CEA Saclay, DEN/DM2S/SEMT/LISN, 91191 Gif sur Yvette Cedex (France); Barthelet, B. [EDF/EPN, Site Cap Ampere, 1 place Pleyel 93207, Saint Denis Cedex 1 (France); Le Delliou, P. [EDF Pole Industrie-Division R and D, Site des Renardieres, Route de Sens, Ecuelles, 77250 Moret sur Loing Cedex (France); Rougier, V. [EDF/UTO SIS/GAM, 6, avenue Montaigne, 93192 Noisy le Grand (France); Naudin, C. [EDF/SEPTEN, 12-14, Avenue Dutrievoz, 69628 Villeurbanne Cedex (France); Gilles, P.; Triay, M. [AREVA ANP, Tour AREVA, 92084 Paris La Defense Cedex 16 (France)

    2007-10-15

    French nuclear codes include flaw assessment procedures: the RSE-M Code 'Rules for In-service Inspection of Nuclear Power Plant Components' and the RCC-MR code 'Design and Construction rules for mechanical components of FBR nuclear islands and high-temperature applications'. An important effort of development of these analytical methods has been made for the last 10 years in the frame of collaboration between CEA, EDF and AREVA-NP, and in the frame of R and D actions involving CEA and IRSN. These activities have led to a unification of the common methods of the two codes. The calculation of fracture mechanics parameters, and in particular the stress-intensity factor K{sub I} and the J integral, has been widely developed for industrial configurations. All the developments have been integrated in the 2005 edition of the RSE-M and in the 2007 edition of the RCC-MR. This series of articles is composed of 5 parts: the first part presents an overview of the methods proposed in the RCC-MR and RSE-M codes. Parts II-IV provide compendia for specific components. The geometries are plates (part II), pipes (part III) and elbows (part IV). Part V presents validation, with details on the accuracy of the proposed analytical method. This third part in the series presents details of the stress intensity factor and J calculations for cracked pipes. General data applicable for all defect geometries are first presented, and then, compendia for K{sub I} and {sigma}{sub ref} calculations are provided for specific cases.

  16. CBIOS Science Sessions - 2016 - Part I and III National Symposium on Nanoscience and Biomedical Nanotechnology - Proceedings

    Directory of Open Access Journals (Sweden)

    L. Monteiro Rodrigues, et al.

    2016-05-01

    Full Text Available CBiOS Science Sessions - 2016 – Part 1 New methods to explore efficacy and safety of natural origin products; Stefânia Duz Delsin Effectiveness of Hypopressive Exercises in women with pelvic floor dysfunctions; Beatriz Navarro Brazález Indoor air quality in baby rooms: a study about VOC levels; Raquel Rodrigues dos Santos, Ana Sofia Fernandes e Liliana Mendes A medicinal chemistry approach for the development of novel anti-tumor agentes; Maria M. M. Santos Isolation, modelling and phytosome forms of antibacterial and anti-proliferative compounds from Plectranthus spp; Diogo Matias Intellectual Property – Patenting Propriedade Intelectual – Patenteamento Rui Gomes Biomarkers in wastewater; Álvaro Lopes A Contribution for a Better Comprehension of Donkey Dentistry: the Importance of Dental Care; João Brandão Rodrigues Characterization of Lusitano’s Pure Blood Pressure Centers using two pressure plates; Pequito M.; Gomes-Costa M.; Prazeres J.; Bragança M.; Roupa I.; Fonseca R.G.; Abrantes J. Application of photoplethysmography to monitor heart rate in dogs; Rui Assunção, Henrique Silva, João Requicha, Luis Lobo, Luis Monteiro Rodrigues Looking into the oscillatory properties of the laser Doppler flowmetry signal in human microcirculation; Henrique Silva, Hugo Ferreira, Marie-Ange Renault, Alain-Pierre Gadeau, Julia Buján, LM Rodrigues III Symposium of Nanoscience and Biomedical Nanotechnology – Proceedings April 15/04/2016 Lisboa - Universidade Lusófona Honor Commitee /Comissão de Honra Magnífico Reitor da Universidade Lusófona, Mário Moutinho Presidente do Conselho de Administração da Universidade Lusófona, Manuel de Almeida Damásio Sr. Bastonário da Ordem dos Engenheiros, Carlos Matias Ramos Sr. Bastonário da Ordem dos Médicos, José Silva Vice-presidente do Conselho de Enfermagem, Maria José Costa Dias Presidente da Associação Nacional de Farmácias, Paulo Cleto Duarte Presidente da Sociedade Portuguesa de Ci

  17. LHC Beam Dump Design Study - Part III : Off-normal operating conditions

    CERN Document Server

    Bruno, L; Ross, M; Sala, P

    2000-01-01

    The LHC beam dump design study has been preliminarily substantiated by energy deposition simulations (Part I) and heat transfer analyses (Part II). The present report is devoted to the abnormal operating conditions induced by a malfunction of the beam diluters. A general approach to the analysis of off-normal operation is presented, which is derived from standard design norms adopted in the nuclear industry. Attention is focused mainly on the carbon core, which is longitudinally split into segments of different density in order to better distribute the deposited energy. The maximum energy density it absorbs decreases by at least 33%, compared to a uniform standard density carbon core. This structure may sustain any partial sweep failure without major damage, up to the ultimate beam intensity and energy. To minimise the risks inherent in a fully unswept beam, a sacrificial graphite mandrel will be placed on the core axis, surrounded by a thick high strength carbon-carbon composite tube. With this arrangement, ...

  18. CBIOS Science Sessions - 2016 - Part I and III National Symposium on Nanoscience and Biomedical Nanotechnology - Proceedings

    OpenAIRE

    L. Monteiro Rodrigues, et al.

    2016-01-01

    CBiOS Science Sessions - 2016 – Part 1 New methods to explore efficacy and safety of natural origin products; Stefânia Duz Delsin Effectiveness of Hypopressive Exercises in women with pelvic floor dysfunctions; Beatriz Navarro Brazález Indoor air quality in baby rooms: a study about VOC levels; Raquel Rodrigues dos Santos, Ana Sofia Fernandes e Liliana Mendes A medicinal chemistry approach for the development of novel anti-tumor agentes; Maria M. M. Santos Isolation, modelling ...

  19. PIO I-II tendencies case study. Part 1. Mathematical modeling

    Directory of Open Access Journals (Sweden)

    Adrian TOADER

    2010-03-01

    Full Text Available In the paper, a study is performed from the perspective of giving a method to reduce the conservatism of the well known PIO (Pilot-Induced Oscillation criteria in predicting the susceptibility of an aircraft to this very harmful phenomenon. There are three interacting components of a PIO – the pilot, the vehicle, and the trigger (in fact, the hazard. The study, conceived in two parts, aims to underline the importance of human pilot model involved in analysis. In this first part, it is shown, following classical sources, how the LQG theory of control and estimation is used to obtain a complex model of human pilot. The approach is based on the argument, experimentally proved, that the human behaves “optimally” in some sense, subject to his inherent psychophysical limitations. The validation of such model is accomplished based on the experimental model of a VTOL-type aircraft. Then, the procedure of inserting typical saturation nonlinearities in the open loop transfer function is presented. A second part of the paper will illustrate PIO tendencies evaluation by means of a grapho-analytic method.

  20. Cognitive orientation to daily occupational performance (CO-OP): part III--the protocol in brief.

    Science.gov (United States)

    Polatajko, H J; Mandich, A D; Missiuna, C; Miller, L T; Macnab, J J; Malloy-Miller, T; Kinsella, E A

    2001-01-01

    Parts I and II of this series introduced the Cognitive Orientation to daily Occupational Performance (CO-OP), a new approach to intervention that is based on the premise that cognition plays an important role in the acquisition of occupational skills and the development of occupational competency. Developed for use with children who have occupational performance deficits, CO-OP is an individualized, client-centred approach focused on strategy-based skill acquisition. This third paper in this series presents a brief description of the actual CO-OP protocol including its objectives, prerequisites and key features.

  1. Slag-metal reactions during welding: Part III. Verification of the Theory

    Science.gov (United States)

    Mitra, U.; Eagar, T. W.

    1991-02-01

    A previously developed kinetic model of alloy transfer (Part II)[1] is tested experimentally for transfer of Mn, Si, Cr, P, S, Ni, Cu, and Mo. The results show very good agreement between theory and experiment. The transfer of carbon and oxygen is also discussed. It is shown that the transfer of oxygen into the weld metal occurs in the zone of droplet reactions, whereas oxygen is lost by formation and separation of inclusions in the solidifying weld pool. Methods of applying this analysis to multipass welds and active fluxes containing ferroalloy additions are also described.

  2. Applicability of WaveWatch-III wave model to fatigue assessment of offshore floating structures

    Science.gov (United States)

    Zou, Tao; Kaminski, Miroslaw Lech

    2016-09-01

    In design and operation of floating offshore structures, one has to avoid fatigue failures caused by action of ocean waves. The aim of this paper is to investigate the applicability of WaveWatch-III wave model to fatigue assessment of offshore floating structures. The applicability was investigated for Bluewaters' FPSO (Floating Production, Storage and Offloading) which had been turret moored at Sable field for half a decade. The waves were predicted as sea-state time series consisting of one wind sea and one swell. The predicted waves were compared with wave data obtained from ERA-interim and buoy measurements. Furthermore, the fatigue calculations were also carried out for main deck and side shell locations. It has been concluded that predicted fatigue damages of main deck using WaveWatch-III are in a very good agreement regardless of differences in predicted wind waves and swells caused by differences in wave system partitioning. When compared to buoy measurements, the model underestimates fatigue damages of side shell by approximately 30 %. The reason for that has been found in wider directional spreading of actual waves. The WaveWatch-III wave model has been found suitable for the fatigue assessment. However, more attention should be paid on relative wave directionality, wave system partitioning and uncertainty analysis in further development.

  3. Models for Quarks and Elementary Particles. Part III: What is the Nature of the Gravitational Field?

    Directory of Open Access Journals (Sweden)

    Neumann U. K. W.

    2008-07-01

    Full Text Available The first two parts of this article series dealt with the questions: What is a quark? and What is mass? While the present models lead to a physical idea of the mass, the geometrical theory of the general relativity only shows the effect of mass. From the physical idea of mass, from the idea of the resultant vector (EV as electric flux and from the ideas relating to the magnetic monopole (MMP it follows that the gravitational field is an electrical field. The share of the electrical gravitational flux on the entire electrical flux of a quark is determined from Newton’s empirical gravitational constant G . The superposition of the < fluxes of two quark collectives produces the gravitational force effect between two quark collectives. Gravitational fields reach infinitely far according to our current ideas. Connected with the quark oscillations hinted in the Parts I and II this results in the idea of the < - < flux spreading with infinite speed, having enormous consequences.

  4. Managing the multicultural laboratory, Part III: Putting the cross-cultural tools to work.

    Science.gov (United States)

    Ketchum, S M

    1993-01-01

    This third article provides two case studies that enable laboratory managers to see how the cross-cultural model postulated by Dr. Geert Hofstede can be practically applied to two important issues--staff training and conflict resolution between employees. In addition, the opinions of several managers from a variety of industries are presented to add realism and perspective. This encourages laboratory managers to step outside the laboratory environment and learn from other managers who have years of experience supervising culturally diverse groups of employees. Part I of this series explained what is meant by "culture" and featured the research-based model set forth by Dutch social psychologist and management consultant, Dr. Geert Hofstede. His four dimensions of culture (Power Distance, Masculinity/Femininity, Individualism/Collectivism, and Uncertainty Avoidance) provide a useful framework for understanding the different values, attitudes, and behaviors exhibited by those of different cultural backgrounds. Part II presented advice in the form of 13 anecdotes from experienced cross-cultural managers. Issues of performance management, interpersonal skills, and language and safety were explored in light of the four dimensions. In this third article, abbreviated reference tables adapted from Hofstede's research are presented that make these cross-cultural data more useful for management decision making. Laboratory managers will receive practical, "real world" advice that will help them to positively resolve conflicts and to take full advantage of staff training opportunities.

  5. 49 CFR Appendix B to Part 236 - Risk Assessment Criteria

    Science.gov (United States)

    2010-10-01

    ... upper bound, as estimated with a sensitivity analysis, and the risk value selected must be demonstrated... paths to a mishap as predicted by the safety analysis methodology. The documentation shall be in such a... 49 Transportation 4 2010-10-01 2010-10-01 false Risk Assessment Criteria B Appendix B to Part 236...

  6. Groundwater resources assessment of part of Ilesa, Southwestern ...

    African Journals Online (AJOL)

    An integrated geophysical survey involving the electromagnetic (EM) and direct current resistivity methods was carried out in part of Ilesha, Osun State, underlain by schists, quartzite and quartz schist complex, with a view to assessing the groundwater potential. The EM survey was conducted along eighteen (18) EM profiles ...

  7. Two-loop renormalization in the standard model, part III. Renormalization equations and their solutions

    Energy Technology Data Exchange (ETDEWEB)

    Actis, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Passarino, G. [Torino Univ. (Italy). Dipt. di Fisica Teorica; INFN, Sezione di Torino (Italy)

    2006-12-15

    In part I and II of this series of papers all elements have been introduced to extend, to two loops, the set of renormalization procedures which are needed in describing the properties of a spontaneously broken gauge theory. In this paper, the final step is undertaken and finite renormalization is discussed. Two-loop renormalization equations are introduced and their solutions discussed within the context of the minimal standard model of fundamental interactions. These equations relate renormalized Lagrangian parameters (couplings and masses) to some input parameter set containing physical (pseudo-)observables. Complex poles for unstable gauge and Higgs bosons are used and a consistent setup is constructed for extending the predictivity of the theory from the Lep1 Z-boson scale (or the Lep2 WW scale) to regions of interest for LHC and ILC physics. (orig.)

  8. Dental caries: A complete changeover, PART III: Changeover in the treatment decisions and treatments.

    Science.gov (United States)

    Carounanidy, Usha; Sathyanarayanan, R

    2010-10-01

    Comprehensive management of dental caries should involve the management of disease as well as the lesion. Current decision making process in cariology is influenced by numerous factors such as the size/ depth/ activity of the carious lesion and age/ the caries risk status of the patient. Treatment decisions should involve planning the non-operative/ preventive treatment for non-cavitated or early cavitated lesions and also formulating operative treatment for cavitated lesions. Apart from these two responsibilities, a clinician should also be knowledgeable enough to decide when not to interfere in the caries dynamics and how frequently to recall the patient for follow-ups. The non-operative treatment prescriptions vary in dose, intensity and mode of delivery according to the caries risk status. Minimal invasion and maximal conservation of tooth structure has become the essence of current operative treatments. This part of the series elaborates on the paradigm shift in the management of dental caries.

  9. Dental caries: A complete changeover, PART III: Changeover in the treatment decisions and treatments

    Science.gov (United States)

    Carounanidy, Usha; Sathyanarayanan, R

    2010-01-01

    Comprehensive management of dental caries should involve the management of disease as well as the lesion. Current decision making process in cariology is influenced by numerous factors such as the size/ depth/ activity of the carious lesion and age/ the caries risk status of the patient. Treatment decisions should involve planning the non-operative/ preventive treatment for non-cavitated or early cavitated lesions and also formulating operative treatment for cavitated lesions. Apart from these two responsibilities, a clinician should also be knowledgeable enough to decide when not to interfere in the caries dynamics and how frequently to recall the patient for follow-ups. The non-operative treatment prescriptions vary in dose, intensity and mode of delivery according to the caries risk status. Minimal invasion and maximal conservation of tooth structure has become the essence of current operative treatments. This part of the series elaborates on the paradigm shift in the management of dental caries. PMID:21217948

  10. A review of biomass burning emissions part III: intensive optical properties of biomass burning particles

    Directory of Open Access Journals (Sweden)

    J. S. Reid

    2005-01-01

    Full Text Available Because of its wide coverage over much of the globe, biomass burning has been widely studied in the context of direct radiative forcing. Such study is warranted as smoke particles scatter and at times absorb solar radiation efficiently. Further, as much of what is known about smoke transport and impacts is based on remote sensing measurements, the optical properties of smoke particles have far reaching effects into numerous aspects of biomass burning studies. Global estimates of direct forcing have been widely varying, ranging from near zero to −1 W m-2. A significant part of this difference can be traced to varying assumptions on the optical properties of smoke. This manuscript is the third part of four examining biomass-burning emissions. Here we review and discuss the literature concerning measurement and modeling of optical properties of biomass-burning particles. These include available data from published sensitivity studies, field campaigns, and inversions from the Aerosol Robotic Network (AERONET of Sun photometer sites. As a whole, optical properties reported in the literature are varied, reflecting both the dynamic nature of fires, variations in smoke aging processes and differences in measurement technique. We find that forward modeling or ''internal closure'' studies ultimately are of little help in resolving outstanding measurement issues due to the high degree of degeneracy in solutions when using ''reasonable'' input parameters. This is particularly notable with respect to index of refraction and the treatment of black carbon. Consequently, previous claims of column closure may in fact be more ambiguous. Differences between in situ and retrieved ωo values have implications for estimates of mass scattering and mass absorption efficiencies. In this manuscript we review and discuss this community dataset. Strengths and lapses are pointed out, future research topics are prioritized, and best estimates and uncertainties of key

  11. Assessment of Preterm Infants Using the Bayley-III Scales in Korea.

    Science.gov (United States)

    Ahn, Sung Ho; Kim, Soo A

    2017-10-01

    To assess the well-being of preterm newborns using the Bayley-III scales in a Korean-based population, and to evaluate the perinatal risk factors influencing developmental outcome. Using the Bayley-III scales, we assessed 120 preterm infants who were referred for evaluation of neurodevelopmental performance. We subdivided them into an extremely preterm group (n=18) and a very/moderate to late preterm group (n=102). Bayley-III mean scores and the rate of infants showing a delay were compared for both groups. The relationship between perinatal risk factors and Bayley-III scores was analyzed. The risk factors were considered as very low birth weight, history of neonatal medical problems, and abnormal radiologic findings in brain magnetic resonance images (MRIs). Although no significant differences in mean scores were observed between the extremely preterm group and the very/moderate to late preterm group, the rate of babies showing developmental delay in motor composite scores was significantly higher in the extremely preterm group. The proportions of preterm infants with cognitive, language, and motor delays were 38.3%, 26.7%, and 35.0%, respectively. Very low birth weight was a significant risk factor for low cognitive, language, and motor composite scores. Also, abnormal radiologic findings on brain MRI were significant indicators of lower motor composite scores. Cognitive development was the most frequently delayed domain in preterm infants and motor development was more frequently delayed in the extremely preterm group. The very low birth weight and abnormal radiologic findings in brain MRI were predictive factors for neurodevelopmental outcome.

  12. Model assessment of protective barriers: Part 4, Status of FY 1992 work

    Energy Technology Data Exchange (ETDEWEB)

    Fayer, M.J.

    1993-03-01

    Protective barriers are being considered for use at the Hanford Site to enhance the isolation of radioactive wastes from water, plant, and animal intrusion. This study is part of an ongoing effort to assess the effectiveness of protective barriers for isolation of wastes from water. Part I of this study was the original modeling assessment by Pacific Northwest Laboratory of various protective barrier designs (e.g., soil type, vegetation). In Part 11 of this study, additional barrier designs were reviewed and several barrier modeling assumptions were tested. A test plan was then produced that detailed the requirement for hydrologic modeling of protective barriers. Part III of this study summarized the status of work in FY 1990 dealing with two-dimensional flow beneath the barrier and with validation testing using lysimeter data. This report (Part IV) addresses the application of a calibrated model to a much longer data set, the application of the calibrated model to a lysimeter that received a different treatment, and the effect of hysteresis on the behavior of water in the protective barrier.

  13. The Systemic Theory of Living Systems and Relevance to CAM: the Theory (Part III)

    Science.gov (United States)

    2005-01-01

    Western medical science lacks a solid philosophical and theoretical approach to disease cognition and therapeutics. My first two articles provided a framework for a humane medicine based on Modern Biophysics. Its precepts encompass modern therapeutics and CAM. Modern Biophysics and its concepts are presently missing in medicine, whether orthodox or CAM, albeit they probably provide the long sought explanation that bridges the abyss between East and West. Key points that differentiate Systemic from other systems' approaches are ‘Intelligence’, ‘Energy’ and the objective ‘to survive’. The General System Theory (GST) took a forward step by proposing a departure from the mechanistic biological concept—of analyzing parts and processes in isolation—and brought us towards an organismic model. GST examines the system's components and results of their interaction. However, GST still does not go far enough. GST assumes ‘Self-Organization’ as a spontaneous phenomenon, ignoring a causative entity or central controller to all systems: Intelligence. It also neglects ‘Survive’ as the directional motivation common to any living system, and scarcely assigns ‘Energy’ its true inherent value. These three parameters, Intelligence, Energy and Survive, are vital variables to be considered, in our human quest, if we are to achieve a unified theory of life. PMID:16136205

  14. The Systemic Theory of Living Systems and Relevance to CAM: the Theory (Part III

    Directory of Open Access Journals (Sweden)

    José A. Olalde Rangel

    2005-01-01

    Full Text Available Western medical science lacks a solid philosophical and theoretical approach to disease cognition and therapeutics. My first two articles provided a framework for a humane medicine based on Modern Biophysics. Its precepts encompass modern therapeutics and CAM. Modern Biophysics and its concepts are presently missing in medicine, whether orthodox or CAM, albeit they probably provide the long sought explanation that bridges the abyss between East and West. Key points that differentiate Systemic from other systems' approaches are ‘Intelligence’, ‘Energy’ and the objective ‘to survive’. The General System Theory (GST took a forward step by proposing a departure from the mechanistic biological concept—of analyzing parts and processes in isolation—and brought us towards an organismic model. GST examines the system's components and results of their interaction. However, GST still does not go far enough. GST assumes ‘Self-Organization’ as a spontaneous phenomenon, ignoring a causative entity or central controller to all systems: Intelligence. It also neglects ‘Survive’ as the directional motivation common to any living system, and scarcely assigns ‘Energy’ its true inherent value. These three parameters, Intelligence, Energy and Survive, are vital variables to be considered, in our human quest, if we are to achieve a unified theory of life.

  15. History of clubfoot treatment; part III (twentieth century): back to the future.

    Science.gov (United States)

    Hernigou, Philippe

    2017-11-01

    Clubfoot is one of the most common congenital orthopaedic anomalies and was described by Hippocrates in the year 400 BC. From manipulation in antiquity to splint and plaster in the Renaissance the treatment had improved before tenotomy. Many surgical treatments were tested during the nineteenth and twentieth centuries and will be explained in this manuscript; however, the pathology still continues to challenge the paediatric orthopedic surgeon as it has a notorious tendency to relapse, irrespective of whether the foot is treated with conservative or operative means. Part of the reason that the foot relapses is the surgeon's failure to recognize the underlying pathoanatomy. Clubfoot is often automatically assumed to be an equinovarus deformity, however, other permutations and combinations, such as calcaneovalgus, equinovalgus and calcaneovarus, are possible. Out of these combinations, calcaneovalgus occurs most frequently, followed by equinovarus deformity. In more than 90% of the cases, calcaneovalgus responds to conservative treatment, which involves passive manipulation and usually does not require casting or operative intervention as has been demonstrated by Ponseti.

  16. Capsicum--production, technology, chemistry, and quality. Part III. Chemistry of the color, aroma, and pungency stimuli.

    Science.gov (United States)

    Govindarajan, V S

    1986-01-01

    The spice capsicum, the fruits of the genus Capsicum (Family Solanaceae), is a very popular food additive in many parts of the world, valued for the important sensory attributes of color, pungency, and aroma. A large number of varieties are widely cultivated and traded. The characteristic carotenoids of the bright red paprika and cayenne-type chillies, the high character impact aroma stimuli, the methoxy pyrazine of green bell capsicum, the esters of ripe tabasco and the highly potent pungency stimuli, and the capsaicinoids of African and other Asian varieties of chillies, have been of great interest to chemists and biochemists. Research workers in other disciplines such as genetics and breeding, agriculture, and technology have been interested in this spice to develop new varieties with combinations of different optimal levels of the stimuli for the sensory attributes and to maximize production of storable products for specific end uses. Physiologists have been intensely studying the action of the highly potent pungency stimuli and social psychologists the curious aspect of growing acceptance and preference for the initially unacceptable pungency sensation. In the sequential review of all these aspects of the fruit spice Capsicum, the earlier two parts covered history, botany, cultivation and primary processing, and processed products, standards, world production, and trade. In Part III, the chemistry, the compositional variations, synthesis and biosynthesis of the functional components, the carotenoids, the volatiles, and the capsaicinoids are comprehensively reviewed.

  17. Part III: a case study at the Virginia-Maryland Regional College of Veterinary Medicine.

    Science.gov (United States)

    Turnwald, Grant H; Meldrum, J Blair; Sponenberg, D Phillip

    2008-01-01

    This article presents a history of curriculum revision. Internal and external factors prompting the initial curriculum review included the Pew Report, a vision in the college for reform, and faculty retreats focusing on curriculum. The reformed curriculum was designed around a "core plus elective" strategy and was implemented following development by faculty representatives and approval by college and university levels of review. The curriculum was reviewed after being revised and after new courses were first offered, with further review of a few courses with specific challenges. Outcomes assessment was performed and curricular adjustments made. Challenges that arose during the process included organizing and documenting content as well as communicating the content and philosophy of the new curriculum to the various affected constituencies. A summary of factors considered essential to the successful design, implementation, and review of the new curriculum is presented; the majority of these factors would be applicable to reforms at other institutions.

  18. Dispersion of a Passive Scalar Fluctuating Plume in a Turbulent Boundary Layer. Part III: Stochastic Modelling

    Science.gov (United States)

    Marro, Massimo; Salizzoni, Pietro; Soulhac, Lionel; Cassiani, Massimo

    2018-01-01

    We analyze the reliability of the Lagrangian stochastic micromixing method in predicting higher-order statistics of the passive scalar concentration induced by an elevated source (of varying diameter) placed in a turbulent boundary layer. To that purpose we analyze two different modelling approaches by testing their results against the wind-tunnel measurements discussed in Part I (Nironi et al., Boundary-Layer Meteorology, 2015, Vol. 156, 415-446). The first is a probability density function (PDF) micromixing model that simulates the effects of the molecular diffusivity on the concentration fluctuations by taking into account the background particles. The second is a new model, named VPΓ, conceived in order to minimize the computational costs. This is based on the volumetric particle approach providing estimates of the first two concentration moments with no need for the simulation of the background particles. In this second approach, higher-order moments are computed based on the estimates of these two moments and under the assumption that the concentration PDF is a Gamma distribution. The comparisons concern the spatial distribution of the first four moments of the concentration and the evolution of the PDF along the plume centreline. The novelty of this work is twofold: (i) we perform a systematic comparison of the results of micro-mixing Lagrangian models against experiments providing profiles of the first four moments of the concentration within an inhomogeneous and anisotropic turbulent flow, and (ii) we show the reliability of the VPΓ model as an operational tool for the prediction of the PDF of the concentration.

  19. Color stability and colorant effect on maxillofacial elastomers. Part III: weathering effect on color.

    Science.gov (United States)

    Haug, S P; Andres, C J; Moore, B K

    1999-04-01

    Maxillofacial prostheses are serviceable for approximately 6 months, after which they need to be refabricated because of the deterioration of color and physical properties. This third article in a 3-part series evaluated the color stability of commonly used colorant-elastomer combinations as a result of exposure to weathering. Fifteen specimens were fabricated for each of the 3 elastomers (Silastic medical adhesive type A, Silastic 4-4210, and Silicone A-2186) and 6 colorants (dry earth pigments, rayon fiber flocking, artist's oil paints, kaolin, liquid cosmetics, and no colorant) for a total of 270 specimens (18 groups of 15 specimens). The 15 specimens of each elastomer-colorant combination were separated into 3 test condition groups (control, time passage, and natural weathering) of 5 specimens per test condition group. Control specimens were evaluated within 1 month of fabrication. The time passage group was sealed in glass containers and kept in the dark for 6 months before testing. The natural weathering groups were placed on the roof of the dental school for 6 months and exposed to sunlight and weathering. Color and optical density data for each elastomer-colorant combination were subjected to a 1-way analysis of variance to examine effects among test conditions (control, time passage, and weathering). When significant differences were observed, the Student-Newman-Keuls multiple range test was performed to identify differences in elastomer-colorant combinations among each test condition at a significance level of .05. Changes in color, as a result of weathering, were noted in many of the colorant-elastomer combinations. Also, color change occurred not only to the colored, but also to uncolored materials over time without exposure to weathering. Clinically, the addition of colorants could have a stabilizing effect on the elastomer color when it is exposed to weathering.

  20. A Study of Future Communications Concepts and Technologies for the National Airspace System-Part III

    Science.gov (United States)

    Ponchak, Denise S.; Apaza, Rafael D.; Wichgersm Joel M.; Haynes, Brian; Roy, Aloke

    2014-01-01

    The National Aeronautics and Space Administration (NASA) Glenn Research Center (GRC) is investigating current and anticipated wireless communications concepts and technologies that the National Airspace System (NAS) may need in the next 50 years. NASA has awarded three NASA Research Announcements (NAR) studies with the objective to determine the most promising candidate technologies for air-to-air and air-to-ground data exchange and analyze their suitability in a post-NextGen NAS environment. This paper will present progress made in the studies and describe the communications challenges and opportunities that have been identified as part of the study. NASA's NextGen Concepts and Technology Development (CTD) Project integrates solutions for a safe, efficient and high-capacity airspace system through joint research efforts and partnerships with other government agencies. The CTD Project is one of two within NASA's Airspace Systems Program and is managed by the NASA Ames Research Center. Research within the CTD Project is in support the 2011 NASA Strategic Plan Sub-Goal 4.1: Develop innovative solutions and advanced technologies, through a balanced research portfolio, to improve current and future air transportation. The focus of CTD is on developing capabilities in traffic flow management, dynamic airspace configuration, separation assurance, super density operations and airport surface operations. Important to its research is the development of human/automation information requirements and decisionmaking guidelines for human-human and human-machine airportal decision-making. Airborne separation, oceanic intrail climb/descent and interval management applications depend on location and intent information of surrounding aircraft. ADS-B has been proposed to provide the information exchange, but other candidates such as satellite-based receivers, broadband or airborne internet, and cellular communications are possible candidate's.

  1. Proprioception in musculoskeletal rehabilitation. Part 2: Clinical assessment and intervention.

    Science.gov (United States)

    Clark, Nicholas C; Röijezon, Ulrik; Treleaven, Julia

    2015-06-01

    Proprioception can be impaired in gradual-onset musculoskeletal pain disorders and following trauma. Understanding of the role of proprioception in sensorimotor dysfunction and methods for assessment and interventions is of vital importance in musculoskeletal rehabilitation. In Part 1 of this two-part Masterclass we presented a theory-based overview of the role of proprioception in sensorimotor control, causes and findings of altered proprioception in musculoskeletal conditions, and general principles of assessment and interventions. The aim of this second part is to present specific methods for clinical assessment and interventions to improve proprioception in the spine and extremities. Clinical assessment of proprioception can be performed using goniometers, inclinometers, laser-pointers, and pressure sensors. Manual therapy, taping, and bracing can immediately enhance proprioception and should be used to prepare for exercise interventions. Various types of exercise (active joint repositioning, force sense, co-ordination, muscle performance, balance/unstable surface, plyometric, and vibration training) should be employed for long-term enhancement of proprioception. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Standing on shaky ground- US patent-eligibility of isolated DNA and genetic diagnostics after AMP v. USPTO - Part III (unsolved questions & subsequent case law)

    DEFF Research Database (Denmark)

    Minssen, Timo; Nilsson, David

    2012-01-01

    review (5). Why a potential Supreme Court review of AMP v. USPTO would indeed be a much welcomed and necessary development is now analyzed in Part III. This part will elaborate on the myriad of unsolved questions raised by both AMP v. USPTO and a bulk of subsequent case law addressing the patent...

  3. Screening for Voice Disorders in Older Adults (RAVI)-Part III: Cutoff Score and Clinical Consistency.

    Science.gov (United States)

    Pernambuco, Leandro; Espelt, Albert; Costa de Lima, Kenio

    2017-01-01

    The aim of the study was to determine the cutoff score and clinical consistency of "Screening for Voice Disorders in Older Adults" (RAVI-Rastreamento de Alterações Vocais em Idosos). This is a prospective, nonrandomized, cross-sectional diagnostic study. A sample of 301 subjects, including both sexes, aged 60 and more, and all of whom were living in either a community or an institution, was studied. To determine which subjects had or did not have voice problems, we used a composite reference standard (auditory-perceptual analysis of sustained vowel phonation, auditory-perceptual analysis of connected speech, and vocal self-assessment). The best cutoff score was identified using the receiver operating characteristic (ROC) curve analysis. The clinical consistency indicators were co-positivity, co-negativity, positive and negative predictive values, positive and negative likelihood ratio, and test efficiency. The significance level was 5%. The area under the ROC curve was 0.763 (95% confidence interval: 0.706-0.821), and the best cutoff score for determining which older adults had or did not have a voice disorder was 2. All clinical consistency indicators were satisfactory: co-positivity (79%), co-negativity (60%), predictive positive value (51%), negative predictive value (84%), positive likelihood ratio (2.01), negative likelihood ratio (0.34), and test efficiency (69%). RAVI has satisfactory indicators of clinical consistency and is able to determine which older adults have voice disorders by a cutoff score of 2. The use of RAVI as a screening tool is recommended to help determine the prevalence of voice disorders in older adults. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  4. Electronics and telecommunications in Poland, issues and perspectives: Part III. Innovativeness, applications, economy, development scenarios, politics

    Science.gov (United States)

    Modelski, Józef; Romaniuk, Ryszard

    2010-09-01

    important role of ET is combined with the existence in the society of an adequate infrastructure which recreates the full development cycle of high technology embracing: people, institutions, finances and logistics, in this also science, higher education, education, continuous training, dissemination and outreach, professional social environment, legal basis, political support and lobbying, innovation structures, applications, industry and economy. The digest of chosen development tendencies in ET was made here from the academic perspective, in a wider scale and on this background the national one, trying to situate this branch in the society, determine its changing role to build a new technical infrastructure of a society based on knowledge, a role of builder of many practical gadgets facilitating life, a role of a big future integrator of today's single bricks into certain more useful unity. This digest does not have a character of a systematic analysis of ET. It is a kind of an arbitrary utterance of the authors inside their field of competence. The aim of this paper is to take an active part in the discussion of the academic community in this country on the development strategy of ET, choice of priorities for cyclically rebuilding economy, in competitive environments. The review paper was initiated by the Committee of Electronics and Telecommunications of Polish Academy of Sciences and was published in Polish as introductory chapter of a dedicated expertise, printed in a book format. This version makes the included opinions available for a wider community.

  5. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08.

    Science.gov (United States)

    Allegra, Carmen J; Yothers, Greg; O'Connell, Michael J; Sharif, Saima; Petrelli, Nicholas J; Colangelo, Linda H; Atkins, James N; Seay, Thomas E; Fehrenbacher, Louis; Goldberg, Richard M; O'Reilly, Seamus; Chu, Luis; Azar, Catherine A; Lopa, Samia; Wolmark, Norman

    2011-01-01

    The National Surgical Adjuvant Breast and Bowel Project C-08 trial was designed to investigate the safety and efficacy of adding bevacizumab to modified FOLFOX6 (mFOLFOX6; ie, infusional/bolus fluorouracil, leucovorin, and oxaliplatin) for the adjuvant treatment of patients with stages II to III colon cancer. Patients received mFOLFOX6 every 2 weeks for 26 weeks alone or modified as FOLFOX6 + bevacizumab (5 mg/kg every 2 weeks for 52 weeks [ie, experimental group]). The primary end point was disease-free survival (DFS). Among 2,672 analyzed patients, demographic factors were well balanced by treatment. With a median follow-up of 35.6 months, the addition of bevacizumab to mFOLFOX6 did not result in an overall significant increase in DFS (hazard ratio [HR], 0.89; 95% CI, 0.76 to 1.04; P = .15). The point estimates for 3-year DFS for the overall population were 77.4% and 75.5% for the experimental and control arms, respectively. For patients with stages II and III diseases, these same estimates were 87.4% and 84.7%, respectively, for stage II and 74.2% and 72.4%, respectively, for stage III. Exploratory analyses found that the effect of bevacizumab on DFS was different before and after a 15-month landmark (time-by-treatment interaction P value < .0001). Bevacizumab had a strong effect before the landmark (HR, 0.61; 95% CI, 0.48 to 0.78; P < .001) but no significant effect after (HR, 1.22; 95% CI, 0.98 to 1.52; P = .076). Bevacizumab for 1 year with mFOLFOX6 does not significantly prolong DFS in stages II and III colon cancer. However, a significant but transient effect during bevacizumab exposure was observed in the experimental arm. We postulate that this observation reflects a biologic effect during bevacizumab exposure. Given the lack of improvement in DFS, the use of bevacizumab cannot be recommended for use in the adjuvant treatment of patients with colon cancer.

  6. Dental compensation for skeletal Class III malocclusion by isolated extraction of mandibular teeth. Part 1: Occlusal situation 12 years after completion of active treatment.

    Science.gov (United States)

    Zimmer, Bernd; Schenk-Kazan, Sarah

    2015-05-01

    The purpose of this work was to statistically evaluate the outcomes achieved by isolated extraction of mandibular teeth (second premolars or first molars) for Class III compensation. Part A of the study dealt with the quality of outcomes at the end of active treatment, using weighted Peer Assessment Rating (PAR) scores determined on the basis of casts for 25 (14 female and 11 male) consecutive patients aged 16 ± 1.7 years at the time of debonding. These results were compared to the scores in a randomly selected control group of 25 (14 female and 11 male) patients who were 14.7 ± 1.9 years old at debonding. Part B evaluated the long-term stability of the outcomes based on 12 (all of them female) patients available for examination after a mean of 11.8 years. The mean weighted PAR scores obtained in both study parts were analyzed for statistical differences using a two-tailed paired Student's t-test at a significance level of p ≤ 0.05. Mean weighted PAR scores of 4.76 ± 3.94 and 3.92 ± 3.44 were obtained in the Class III extraction group and the control group, respectively, at the end of active treatment. This difference was not significant (p = 0.49). Among the 12 longitudinal patients, the mean score increased from 4 ± 3.46 at debonding to 6.25 ± 3.67 by the end of the 11.8-year follow-up period. This difference was significant (p = 0.0008). Treatment of Class III anomalies by isolated extraction of lower premolars or molars can yield PAR scores similar to those achieved by standard therapies. These scores, while increasing significantly, remained at a clinically acceptable level over 11.8 years. Hence this treatment modality--intended for cases that border on requiring orthognathic surgery--may also be recommended from a long-term point of view.

  7. Compensation of skeletal Class III malocclusion by isolated extraction of mandibular teeth: Part 2: Skeletal, dentoalveolar and soft tissue parameters in comparison with nonextraction Class III therapies.

    Science.gov (United States)

    Zimmer, Bernd; Gaida, Sarah; Dathe, Henning

    2016-03-01

    To retrospectively compare two compensatory approaches taken in skeletal Class III patients during the main treatment stage, including a study group of multiband treatment plus isolated extraction of mandibular teeth and a control group of multiband treatment without extraction of teeth. The extraction group included 22 (12 female, 10 male) patients receiving compensatory multiband treatment for a mean of 3.47 ± 1.14 years and 16.22 ± 1.92 years old at debonding. The nonextraction group included 24 (14 female, 10 male) patients undergoing multiband treatment for 2.76 ± 1.28 years and 15.38 ± 1.46 years old at debonding. Lateral cephalograms obtained at baseline and upon completion of active treatment were traced for skeletal, dentoalveolar, and soft tissue parameters. Welch and Wilcoxon tests were used to analyze intergroup differences (initial values, final values, initial-to-final changes) and within-group differences (p < 0.05). Upon completion of active treatment, the only significant intergroup differences were noted for U1NA and L1ML. Significant within-group changes over the courses of treatment were seen for SNB, MLNL, U1NA, U1NL, L1NB, L1ML, H-angle, ULipEL, and LLipEL (extraction group) or for SNB, ANB, individual ANB, Wits appraisal, U1NA, U1NL, H-angle, Naslab-a, ULipEL, and LLipEL (nonextraction group). Parameters that changed by significantly different amounts in both groups included Wits appraisal, L1NB, L1ML, and LLipEL. The added value of isolated extraction therapy basically lies in increasing the potential for retruding the lower incisor inclinations, so that compensatory treatment becomes an option even in selected patients presenting with adverse occlusal situations that would otherwise require orthognathic surgery. Given the successful outcomes in both groups, which had been established by Peer Assessment Rating (PAR) scores, it was possible to define the skeletal, dentoalveolar, and soft tissue characteristics of successful treatment more

  8. Estudo longitudinal das habilidades intelectuais de idosos avaliados com a WAIS-III Longitudinal study of intellectual abilities of elderly people assessed by WAIS-III

    Directory of Open Access Journals (Sweden)

    Ana Carolina Zeferino Menezes

    2011-01-01

    Full Text Available Dados indicam que o envelhecimento, ainda que saudável, acarreta um declínio normal no desempenho intelectual. O presente estudo teve por objetivo investigar o desenvolvimento intelectual de idosos em diferentes domínios avaliados pela WAIS-III. A partir de um delineamento longitudinal, 47 participantes foram divididos em duas faixas etárias: idosos-jovens (até 74 anos e idosos-idosos (acima de 75 anos e seus desempenhos foram comparados após oito anos de intervalo. Resultados mostraram que idosos-jovens apresentaram ganhos nas habilidades avaliadas, embora em apenas dois índices estes tenham sido estatisticamente significativos. Com relação às capacidades de compreensão verbal e linguagem, os ganhos eram esperados. Já Memória, Organização Perceptual, Velocidade de Processamento, QI de Execução e Total não se comportaram como grande parte dos estudos reporta. Resultados para os idosos-idosos estão de acordo com a literatura: habilidades vulneráveis (organização perceptual, aprendizagem, memória, resolução de problemas e velocidade de processamento tiveram decréscimos após os oito anos entre as avaliações. Embora nem todos os resultados tenham sido significativos, corroboram dados de pesquisas que definem a idade de declínios significativos após os 75 anos. Concluindo, os resultados indicaram que os idosos não apresentaram declínio nas habilidades intelectuais avaliadas até a idade de 74 anos, a partir de quando alguma perda foi encontrada. A velocidade de processamento foi a única habilidade que apresentou declínio significativo. Portanto, as variações nos desempenhos não caracterizam um padrão de declínio generalizado, ou seja, não ocorrem em todas as habilidades e variam conforme a idade.Data have indicated that aging, even if in a healthy process, lead to a normal decrease in cognitive performance. The current study aims at investigating the intellectual development of elderly people in different

  9. Summary for Policymakers IPCC Fourth Assessment Report, WorkingGroup III

    Energy Technology Data Exchange (ETDEWEB)

    Barker, Terry; Bashmakov, Igor; Bernstein, Lenny; Bogner,Jean; Bosch, Peter; Dave, Rutu; Davidson, Ogunlade; Fisher, Brian; Grubb,Michael; Gupta, Sujata; Halsnaes, Kirsten; Heij, Bertjan; Kahn Ribeiro,Suzana; Kobayashi, Shigeki; Levine, Mark; Martino, Daniel; MaseraCerutti, Omar; Metz, Bert; Meyer, Leo; Nabuurs, Gert-Jan; Najam, Adil; Nakicenovic, Nebojsa; Rogner, Hans Holger; Roy, Joyashree; Sathaye,Jayant; Schock, Robert; Shukla, Priyaradshi; Sims, Ralph; Smith, Pete; Swart, Rob; Tirpak, Dennis; Urge-Vorsatz, Diana; Zhou, Dadi

    2007-04-30

    A. Introduction 1. The Working Group III contribution to theIPCC Fourth Assessment Report (AR4) focuses on new literature on thescientific, technological, environmental, economic and social aspects ofmitigation of climate change, published since the IPCC Third AssessmentReport (TAR) and the Special Reports on COB2B Capture and Storage (SRCCS)and on Safeguarding the Ozone Layer and the Global Climate System (SROC).The following summary is organised into six sections after thisintroduction: - Greenhouse gas (GHG) emission trends, - Mitigation in theshort and medium term, across different economic sectors (until 2030), -Mitigation in the long-term (beyond 2030), - Policies, measures andinstruments to mitigate climate change, - Sustainable development andclimate change mitigation, - Gaps in knowledge. References to thecorresponding chapter sections are indicated at each paragraph in squarebrackets. An explanation of terms, acronyms and chemical symbols used inthis SPM can be found in the glossary to the main report.

  10. Metabolism. Part III: Lipids.

    Science.gov (United States)

    Bodner, George M.

    1986-01-01

    Describes the metabolic processes of complex lipids, including saponification, activation and transport, and the beta-oxidation spiral. Discusses fatty acid degradation in regard to biochemical energy and ketone bodies. (TW)

  11. Management strategies to effect change in intensive care units: lessons from the world of business. Part III. Effectively effecting and sustaining change.

    Science.gov (United States)

    Gershengorn, Hayley B; Kocher, Robert; Factor, Phillip

    2014-03-01

    Reaping the optimal rewards from any quality improvement project mandates sustainability after the initial implementation. In Part III of this three-part ATS Seminars series, we discuss strategies to create a culture for change, improve cooperation and interaction between multidisciplinary teams of clinicians, and position the intensive care unit (ICU) optimally within the hospital environment. Coaches are used throughout other industries to help professionals assess and continually improve upon their practice; use of this strategy is as of yet infrequent in health care, but would be easily transferable and potentially beneficial to ICU managers and clinicians alike. Similarly, activities focused on improving teamwork are commonplace outside of health care. Simulation training and classroom education about key components of successful team functioning are known to result in improvements. In addition to creating an ICU environment in which individuals and teams of clinicians perform well, ICU managers must position the ICU to function well within the hospital system. It is important to move away from the notion of a standalone ("siloed") ICU to one that is well integrated into the rest of the institution. Creating a "pull-system" (in which participants are active in searching out needed resources and admitting patients) can help ICU managers both provide better care for the critically ill and strengthen relationships with non-ICU staff. Although not necessary, there is potential upside to creating a unified critical care service to assist with achieving these ends.

  12. Assessment of the Postoperative Stability of Mandibular Orthognathic Surgery for Correction of Class III Skeletal Malocclusion.

    Science.gov (United States)

    Luchi, Giuliano Henrique Mião; Conci, Ricardo Augusto; Tomazi, Flavio Henrique Silveira; Berticelli, Rosana da Silva; Guarenti, Michel Martins; Fritscher, Guilherme Genehr; Heitz, Cláiton

    2017-01-01

    To assess the stability of mandible position after orthognathic surgery for correction of class III skeletal malocclusion. Twenty adult males, aged 18 to 40 years, with Angle class III skeletal malocclusion underwent preoperative orthodontic treatment for elimination of dental compensations followed by combined maxillomandibular surgery with rigid internal fixation. Lateral cephalograms from each patient, obtained in the natural head position before surgery, immediately after surgery, and at 6-month follow-up, were retrieved from the files of the Pontifical Catholic University of Rio Grande do Sul outpatient Oral and Maxillofacial Surgery clinic and compared. Comparison of craniometric landmark measurements showed that the precision of mandibular setback was compromised in the horizontal plane, with a mean mandibular relapse of 37.75% at point B and 45.85% at point Pg. Improved intercuspation and adaptation of the musculature to the new position of the jaws after orthognathic surgery lead to counterclockwise rotation of the mandible, ultimately displacing the mandible more anteriorly than desired.

  13. Assessment of temporomandibular disorder and occlusion in treated class III malocclusion patients

    Directory of Open Access Journals (Sweden)

    Karyna Valle-Corotti

    2007-04-01

    Full Text Available OBJECTIVE: The aims of this study were to compare the prevalence of temporomandibular disorders (TMD in individuals submitted to either orthodontic or ortho-surgical Class III malocclusion treatment and to assess the influence of occlusal aspects on TMD severity. MATERIAL AND METHODS: The sample consisted of 50 individuals divided into two groups, according to the type of treatment (orthodontic or orthodontic with orthognathic surgery. The presence of signs and symptoms of TMD was evaluated by an anamnestic questionnaire and a clinical examination, including TMJ and muscle palpation, active mandibular range of motion, joint noises and occlusal examination. RESULTS: Based on the anamnestic questionnaire, 48% had no TMD, 42% had mild TMD and 10% had moderate TMD. The presence and severity of TMD did not show any relationship with the type of orthodontic treatment (p>0.05. The chi-square test showed a positive association (p<0.05 between TMD and non-working side occlusal interferences. CONCLUSION: Based on the methodology used and the results obtained, it may be concluded that Class III orthodontic treatment was not associated with the presence of TMD signs and symptoms and the non-working side contacts can be occlusal factors of risk. There was no significant difference in TMD prevalence between the studied groups (orthodontically treated patients and patients treated with orthodontics followed by orthognathic surgery.

  14. RF thermal and new cold part design studies on TTF-III input coupler for Project-X

    Energy Technology Data Exchange (ETDEWEB)

    Pei, Shilun [Chinese Academy of Sciences (CAS), Beijing (China); Adolphsen, Chris E. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Li, Zenghai [SLAC National Accelerator Lab., Menlo Park, CA (United States); Solyak, Nikolay A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Gonin, Ivan V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2015-05-15

    An RF power coupler is one of the key components in a superconducting (SC) linac. It provides RF power to the SC cavity and interconnects different temperature layers (1.8 K, 4.2 K, 70 K and 300 K). The TTF-III coupler is one of the most promising candidates for the High Energy (HE) linac of Project X, but it cannot meet the average power requirements because of the relatively high temperature rise on the warm inner conductor, so some design modifications will be required. In this paper, we describe our simulation studies on the copper coating thickness on the warm inner conductor with RRR values of 10 and 100. Our purpose is to rebalance the dynamic and static loads, and finally lower the temperature rise along the warm inner conductor. Additionally, to get stronger coupling, better power handling and less multipacting probability, one new cold part design was proposed using a 60 mm coaxial line; the corresponding multipacting simulation studies have also been investigated.

  15. Probability calculations for three-part mineral resource assessments

    Science.gov (United States)

    Ellefsen, Karl J.

    2017-06-27

    Three-part mineral resource assessment is a methodology for predicting, in a specified geographic region, both the number of undiscovered mineral deposits and the amount of mineral resources in those deposits. These predictions are based on probability calculations that are performed with computer software that is newly implemented. Compared to the previous implementation, the new implementation includes new features for the probability calculations themselves and for checks of those calculations. The development of the new implementation lead to a new understanding of the probability calculations, namely the assumptions inherent in the probability calculations. Several assumptions strongly affect the mineral resource predictions, so it is crucial that they are checked during an assessment. The evaluation of the new implementation leads to new findings about the probability calculations,namely findings regarding the precision of the computations,the computation time, and the sensitivity of the calculation results to the input.

  16. An Independent Scientific Assessment of Well Stimulation in California Volume III

    Energy Technology Data Exchange (ETDEWEB)

    Long, Jane C.S. [California Council on Science and Technology, Sacramento, CA (United States); Feinstein, Laura C. [California Council on Science and Technology, Sacramento, CA (United States); Birkholzer, Jens [California Council on Science and Technology, Sacramento, CA (United States); Foxall, William [California Council on Science and Technology, Sacramento, CA (United States); Houseworth, James [California Council on Science and Technology, Sacramento, CA (United States); Jordan, Preston [California Council on Science and Technology, Sacramento, CA (United States); Lindsey, Nathaniel [California Council on Science and Technology, Sacramento, CA (United States); Maddalena, Randy [California Council on Science and Technology, Sacramento, CA (United States); McKone, Thomas [California Council on Science and Technology, Sacramento, CA (United States); Stringfellow, William [California Council on Science and Technology, Sacramento, CA (United States); Ulrich, Craig [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Heberger, Matthew [Pacific Inst., Oakland, CA (United States); Shonkoff, Seth [PSE Healthy Energy, Berkeley, CA (United States); Brandt, Adam [Stanford Univ., CA (United States); Ferrar, Kyle [The FracTracker Alliance, Oakland, CA (United States); Gautier, Donald [DonGautier LLC., Palo Alto, CA (United States); Phillips, Scott [California State Univ. Stanislaus, Turlock, CA (United States); Greenfield, Ben [Univ. of California, Berkeley, CA (United States); Jerrett, Michael L.B. [Univ. of California, Los Angeles, CA (United States)

    2015-07-01

    This study is issued in three volumes. Volume I, issued in January 2015, describes how well stimulation technologies work, how and where operators deploy these technologies for oil and gas production in California, and where they might enable production in the future. Volume II, issued in July 2015, discusses how well stimulation could affect water, atmosphere, seismic activity, wildlife and vegetation, and human health. Volume II reviews available data, and identifies knowledge gaps and alternative practices that could avoid or mitigate these possible impacts. Volume III, this volume, presents case studies that assess environmental issues and qualitative risks for specific geographic regions. The Summary Report summarizes key findings, conclusions and recommendations of all three volumes.

  17. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (83rd, Phoenix, Arizona, August 9-12, 2000). Miscellaneous, Part III.

    Science.gov (United States)

    Association for Education in Journalism and Mass Communication.

    The Miscellaneous, part III section of the proceedings contains the following 11 papers: "The Relationship between Health and Fitness Magazine Reading and Eating-Disordered Weight-Loss Methods among High School Girls" (Steven R. Thomsen, Michelle M. Weber, and Lora Beth Brown); "A Practical Exercise for Teaching Ethical Decision…

  18. Helping General Physical Educators and Adapted Physical Educators Address the Office of Civil Rights Dear Colleague Guidance Letter: Part III--Practitioners and Programs

    Science.gov (United States)

    Poulin, David; Martinez, David; Aenchbacher, Amy; Aiello, Rocco; Doyle, Mike; Hilgenbrinck, Linda; Busse, Sean; Cappuccio, Jim

    2013-01-01

    In Part III of the feature, physical educators and adapted physical educators offer current best practices as models of implementation for readers. Contributions included are: (1) Answer to the Dear Colleague Letter from the Anchorage School District's Adapted Sport Program (David Poulin); (2) Georgia's Adapted Physical Educators Response to the…

  19. The Feasibility of Administering a Practical Clinical Examination in Podiatry at a College of Podiatric Medicine: Results of a Field Trial Under Simulated Part III Test Conditions.

    Science.gov (United States)

    And Others; Valletta, Michael

    1978-01-01

    The results of a practical clinical examination in podiatric medicine administered to fourth-year students are presented. The examination could become the prototype of a Part III practical clinical examination under the auspices of the National Board of Podiatry Examiners. Its feasibility is established and problems and issues are discussed.…

  20. Long maximal incremental tests accurately assess aerobic fitness in class II and III obese men.

    Directory of Open Access Journals (Sweden)

    Stefano Lanzi

    Full Text Available This study aimed to compare two different maximal incremental tests with different time durations [a maximal incremental ramp test with a short time duration (8-12 min (STest and a maximal incremental test with a longer time duration (20-25 min (LTest] to investigate whether an LTest accurately assesses aerobic fitness in class II and III obese men. Twenty obese men (BMI≥35 kg.m-2 without secondary pathologies (mean±SE; 36.7±1.9 yr; 41.8±0.7 kg*m-2 completed an STest (warm-up: 40 W; increment: 20 W*min-1 and an LTest [warm-up: 20% of the peak power output (PPO reached during the STest; increment: 10% PPO every 5 min until 70% PPO was reached or until the respiratory exchange ratio reached 1.0, followed by 15 W.min-1 until exhaustion] on a cycle-ergometer to assess the peak oxygen uptake [Formula: see text] and peak heart rate (HRpeak of each test. There were no significant differences in [Formula: see text] (STest: 3.1±0.1 L*min-1; LTest: 3.0±0.1 L*min-1 and HRpeak (STest: 174±4 bpm; LTest: 173±4 bpm between the two tests. Bland-Altman plot analyses showed good agreement and Pearson product-moment and intra-class correlation coefficients showed a strong correlation between [Formula: see text] (r=0.81 for both; p≤0.001 and HRpeak (r=0.95 for both; p≤0.001 during both tests. [Formula: see text] and HRpeak assessments were not compromised by test duration in class II and III obese men. Therefore, we suggest that the LTest is a feasible test that accurately assesses aerobic fitness and may allow for the exercise intensity prescription and individualization that will lead to improved therapeutic approaches in treating obesity and severe obesity.

  1. Information technology in chemistry research and education: Part I. Ab initio studies on the hydrolysis of aromatic diazonium ions. Part II. Theoretical study and molecular modeling of non-covalent interactions. Part III. Applying information technology in chemistry education

    Science.gov (United States)

    Wu, Zhengyu

    Part I of this dissertation studies the bonding in chemical reactions, while Part II studies the bonding related to inter- and intra-molecular interactions. Part III studies the application of IT technology in chemistry education. Part I of this dissertation (chapter 1 and chapter 2) focuses on the theoretical studies on the mechanism of the hydrolysis reactions of benzenediazonium ion and guaninediazonium ion. The major conclusion is that in hydrolysis reactions the "unimolecular mechanism" actually has to involve the reacting solvent molecule. Therefore, the unimolecular pathway can only serve as a conceptual model but will not happen in the reality. Chapter I concludes that the hydrolysis reaction of benzenediazonium ion takes the direct SN2Ar mechanism via a transition state but without going through a pre-coordination complex. Chapter 2 concludes that the formation of xanthine from the dediazoniation reaction of guaninediazonium ion in water takes the SN2Ar pathway without a transition state. And oxanine might come from an intermediate formed by the bimolecular deprotonation of the H atom on N3 of guaninediazonium ion synchronized with the pyrimidine ring opening reaction. Part II of this dissertation includes chapters 3, 4, and 5. Chapter 3 studies the quadrupole moment of benzene and quadrupole-quadrupole interactions. We concluded that the quadrupole-quadrupole interaction is important in the arene-arene interactions. Our study shows the most stable structure of benzene dimer is the point-to-face T-shaped structure. Chapter 4 studies the intermolecular interactions that result in the disorder of the crystal of 4-Chloroacetophenone-(4-methoxyphenylethylidene). We analyzed all the nearest neighbor interactions within that crystal and found that the crystal structure is determined by its thermo-dynamical properties. Our calculation perfectly reproduced the percentage of parallel-alignment of the crystal. Part III of this dissertation is focused on the

  2. Psychometric assessment of DSM-III personality disorders: another facet of the problem.

    Science.gov (United States)

    Titscher, E; Opgenoorth, E; Ruhs, A; Schuster, P

    1990-01-01

    An empirical study with the Personality Diagnostic Questionnaire, which in substance follows exactly the criteria of personality disorders described in the DSM-III, is used to highlight a number of problems connected with the DSM-III. Criticisms of the DSM-III previously expressed by other authors, e.g. concerning multiple choice between characteristics and equal weighting of different symptoms, are supported by this empirical study.

  3. German design approaches for activated sludge process with regard to nitrogen removal : part three: sensibility design analyses; Approcci tedeschi al dimensionamento dei sistemi a fanghi attivi per la rimozione dell`azoto : parte III: analisi di sensibilita` progettuale

    Energy Technology Data Exchange (ETDEWEB)

    Tatano, F. [Milan Politecnico (Italy). Sez. Ambientale

    1996-04-01

    The paper describes and analyzes the most recent German static or steady state design criteria of the sludge process with regard to nitrogen removal. Design sensibility analyses of the HSG criterion and the Kayser criterion are developed in this Part III.

  4. Systematic review of guidelines for the assessment and management of high-grade anal intraepithelial neoplasia (AIN II/III).

    Science.gov (United States)

    Alam, N N; White, D A; Narang, S K; Daniels, I R; Smart, N J

    2016-02-01

    There is ambiguity with regard to the optimal management of anal intraepithelial neoplasia (AIN) III. The aim of this review was to assess and compare international/national society guidelines currently available in the literature on the management, treatment and surveillance of AIN III. We also aimed to assess the quality of the studies used to compile the guidelines and to clarify the terminology used in histological assessment. An electronic search of PubMed and Embase was performed using the search terms 'anal intraepithelial neoplasia', 'AIN', 'anal cancer', 'guidelines', 'surveillance' and 'management'. Literature reviews and guidelines or practice guidelines in peer reviewed journals from 1 January 2000 to 31 December 2014 assessing the treatment, surveillance or management of patients with AIN related to human papilloma virus were included. The guidelines identified by the search were assessed for the quality of evidence behind them using the Oxford Centre for Evidence-based Medicine 2011 Levels of Evidence. The database search identified 5159 articles and two further guidelines were sourced from official body guidelines. After inclusion criteria were applied, 28 full-text papers were reviewed. Twenty-five of these were excluded, leaving three guidelines for inclusion in the systematic review: those published by the Association of Coloproctology of Great Britain and Ireland, the American Society of Colon and Rectal Surgeons and the Italian Society of Colorectal Surgery. No guidelines were identified on the management of AIN III from human papilloma virus associations and societies. All three guidelines agree that a high index of clinical suspicion is essential for diagnosing AIN with a disease-specific history, physical examination, digital rectal examination and anal cytology. There is interchange of terminology from high-grade AIN (HGAIN) (which incorporates AIN II/III) and AIN III in the literature leading to confusion in therapy use. Treatment varies

  5. Statistical assessment – as a part of security assessment applied to a block cipher

    Directory of Open Access Journals (Sweden)

    Ioana Roxana Dragomir

    2016-09-01

    Full Text Available The security provided by the block cipher algorithms is a top modern approached issue within the specific researches. The security assessment of a block algorithm involves the assessing and testing of components, the statistical testing of algorithm and last, but not least, the cryptanalysis. This paper intends to approach a part of this issue by presenting one of the security assessment stages, namely the component analysis, together with the statistical testing of the block cipher. The statistical testing may be considered as a first step in the security assessing of a block algorithm. The statistical testing of randomness of the block cipher represents an essential phase, both, for the research-development process, and for the assessment process applied to the cryptographic primitives, taking into account that the block algorithms are used on a large scale in cryptographic applications. Assessing them, from a cryptographic point of view, is a highly complex task, which cannot be efficiently accomplished by formal methods. This paper presents several statistical methods of carrying out a security assessment on a block algorithm.

  6. Modeling and experimental assessment of a buried Leu–Ile mutation in dengue envelope domain III

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, Manjiri R. [Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Nakamachi, Koganei-shi, Tokyo, 184-8588 (Japan); Numoto, Nobutaka; Ito, Nobutoshi [Department of Structural Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima Bunkyo-ku, Tokyo, 113-8510 (Japan); Kuroda, Yutaka, E-mail: ykuroda@cc.tuat.ac.jp [Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Nakamachi, Koganei-shi, Tokyo, 184-8588 (Japan)

    2016-02-26

    Envelope protein domain III (ED3) of the dengue virus is important for both antibody binding and host cell interaction. Here, we focused on how a L387I mutation in the protein core could take place in DEN4 ED3, but cannot be accommodated in DEN3 ED3 without destabilizing its structure. To this end, we modeled a DEN4-L387I structure using the Penultimate Rotamer Library and taking the DEN4 ED3 main-chain as a fixed template. We found that three out of seven Ile{sup 387} conformers fit in DEN4 ED3 without introducing the severe atomic clashes that are observed when DEN3 serotype’s ED3 is used as a template. A more extensive search using 273 side-chain rotamers of the residues surrounding Ile{sup 387} confirmed this prediction. In order to assess the prediction, we determined the crystal structure of DEN4-L387I at 2 Å resolution. Ile{sup 387} indeed adopted one of the three predicted rotamers. Altogether, this study demonstrates that the effects of single mutations are to a large extent successfully predicted by systematically modeling the side-chain structures of the mutated as well as those of its surrounding residues using fixed main-chain structures and assessing inter-atomic steric clashes. More accurate and reliable predictions require considering sub-angstrom main-chain deformation, which remains a challenging task. - Highlights: • We mutated L387I of DEN4 ED3 and examined its effects on structure and stability. • We modeled the side-chain of Ile{sup 387} using DEN4 ED3's structure as a template. • We determined the crystal structure of DEN4-L387I and confirmed the modeling. • Side-chain repacking occurring around Ile{sup 387} involved >3 inter-connected residues. • These results explained why L387I mutation in DEN4 ED3 conserves thermostability.

  7. Field Surveys, IOC Valleys. Volume III, Part II. Cultural Resources Survey, Pine and Wah Wah Valleys, Utah.

    Science.gov (United States)

    1981-08-01

    including horse, camel, mammoth, Ertm E-TR-48-III-II 20 musk ox, and certain species of bison, goat, and bear, which had previously inhabited the marsh and...34 - - -9,$.. 𔄃 Im I I I Si to * Location lype/Contents Affiliation 42B@644 rid e over cr ek - P/J depression, cleared areas, Fr elon (f4-5-18-92) ground

  8. Identification of d-Galactan-III As Part of the Lipopolysaccharide of Klebsiella pneumoniae Serotype O1.

    Science.gov (United States)

    Stojkovic, Katarina; Szijártó, Valéria; Kaszowska, Marta; Niedziela, Tomasz; Hartl, Katharina; Nagy, Gábor; Lukasiewicz, Jolanta

    2017-01-01

    Klebsiella pneumoniae is a Gram-negative, ubiquitous bacterium capable of causing severe nosocomial infections in individuals with impaired immune system. Emerging multi-drug resistant strains of this species and particularly carbapenem-resistant strains pose an urgent threat to public health. The lipopolysaccharide (LPS) O-antigen is the main surface antigen. It contributes to the virulence of this species and determines the O-serotype of K. pneumoniae isolates. Among the nine main O-serotypes of K. pneumoniae, O1-and O2-type pathogens are causative agents of over 50% of all infections. Serotype O1, the most common O-serotype, expresses complex LPS consisting of d-galactan-I (a polymer built of → 3)-β-d-Galf-(1 → 3)-α-d-Galp-(1 → repeating units) capped by d-galactan-II (built of [ → 3)-α-d-Galp-(1 → 3)-β-d-Galp-(1 →] repeating units). Galactan-I is present as the sole polymer in O2 serotype. Recently, in case of serotype O2, conversion of galactan-I to galactan-III (→ 3)-β-d-Galf-(1 → 3)-[α-d-Galp-(1 → 4)]-α-d-Galp-(1 →) was reported. Substitution of → 3)-α-d-Galp by a branching terminal α-d-Galp was dependent on the presence of the gmlABC operon and had a major impact on the antigenicity of the galactan polymer. Genetic analysis indicated that 40% of the O1 clinical isolates also carry the gmlABC locus; therefore we aimed to characterize the corresponding phenotype of LPS O-antigens. The presence of galactan-III among O1 strains was proven using galactan-III-specific monoclonal antibodies and confirmed by structural analyses performed using sugar and methylation analysis as well as classical and high-resolution magic angle spinning NMR spectroscopy. By using an isogenic mutant pair, we demonstrated that galactan-III expression was dependent on the presence of glycosyltransferases encoded by gmlABC, as was shown previously for the O2 serotype. Furthermore, the galactan-II structures in O1gml+ strains remained unaffected

  9. Identification of d-Galactan-III As Part of the Lipopolysaccharide of Klebsiella pneumoniae Serotype O1

    Directory of Open Access Journals (Sweden)

    Jolanta Lukasiewicz

    2017-04-01

    Full Text Available Klebsiella pneumoniae is a Gram-negative, ubiquitous bacterium capable of causing severe nosocomial infections in individuals with impaired immune system. Emerging multi-drug resistant strains of this species and particularly carbapenem-resistant strains pose an urgent threat to public health. The lipopolysaccharide (LPS O-antigen is the main surface antigen. It contributes to the virulence of this species and determines the O-serotype of K. pneumoniae isolates. Among the nine main O-serotypes of K. pneumoniae, O1-and O2-type pathogens are causative agents of over 50% of all infections. Serotype O1, the most common O-serotype, expresses complex LPS consisting of d-galactan-I (a polymer built of → 3-β-d-Galf-(1 → 3-α-d-Galp-(1 → repeating units capped by d-galactan-II (built of [ → 3-α-d-Galp-(1 → 3-β-d-Galp-(1 →] repeating units. Galactan-I is present as the sole polymer in O2 serotype. Recently, in case of serotype O2, conversion of galactan-I to galactan-III (→ 3-β-d-Galf-(1 → 3-[α-d-Galp-(1 → 4]-α-d-Galp-(1 → was reported. Substitution of → 3-α-d-Galp by a branching terminal α-d-Galp was dependent on the presence of the gmlABC operon and had a major impact on the antigenicity of the galactan polymer. Genetic analysis indicated that 40% of the O1 clinical isolates also carry the gmlABC locus; therefore we aimed to characterize the corresponding phenotype of LPS O-antigens. The presence of galactan-III among O1 strains was proven using galactan-III-specific monoclonal antibodies and confirmed by structural analyses performed using sugar and methylation analysis as well as classical and high-resolution magic angle spinning NMR spectroscopy. By using an isogenic mutant pair, we demonstrated that galactan-III expression was dependent on the presence of glycosyltransferases encoded by gmlABC, as was shown previously for the O2 serotype. Furthermore, the galactan-II structures in O1gml+ strains remained unaffected

  10. Cephalometric assessment of maxillary length in Serbian children with skeletal class III.

    Science.gov (United States)

    Stojanović, Zdenka; Nikolić, Predrag; Nikodijević, Angelina; Milić, Jasmina; Stojanović, Branislav

    2013-07-01

    Malocclusion of skeletal class III is a complex irregularity of sagittal inter-jaw relationship, which is due to irregularities of sagittal position of one or both of the jaw bones, which is often associated with disproportionate ratio of their length. The aim of this study was to determine whether the length of the jaw of children with skeletal class III in the period of mixed dentition was changed. Fifty children with skeletal class III and the same number of those with skeletal class I, of both sexes, have been selected on the basis of cephalometric analysis of profile tele-x-ray of the head. All the children aged 6-12 had mixed dentition, and were divided according to sex and age into three subgroups within each group. The length of maxilla, mandible and cranial base were measured. Proportions among the lengths measured within each group were found and difference significance in the measured lengths and their proportions among groups and subgroups were evaluated. The children with skeletal class III, compared with the findings in the control group, had significantly lower values of maxillary length, total maxillary length, as well as lower values of their lengths in proportion to lengths of the front or the total length of cranial base and in proportion to mandibular lengths (p children with skeletal class III have significantly shorter maxilla than those with skeletal class I.

  11. Charleso Dickenso kūrybos recepcija lietuvių literatūros kritikoje (III dalis | The Reception of Charles Dickens in Lithuanian Literary Criticism (Part III

    Directory of Open Access Journals (Sweden)

    Regina Rudaitytė

    2012-01-01

    Full Text Available Although traditionally Dickens has always been regarded by Lithuanian critics and literary scholars as an emblematic English writer, one of the great­est representatives of the Victorian realist novel in England, his writing, however, has been given only cursory treatment in Lithuania, almost never until recently crossing the boundaries of biographical ar­ticles, reviews and notices with a biographical slant scattered in the press, particularly, but not only, dur­ing the early stages of reception. There is no book specifically dedicated to Dickens’s art by Lithuanian literary scholars, no comprehensive, fundamental and completely scholarly investigation of his writing. The critical assessment of Dickens’s writing has generally been coming in the form of reviews and articles dedicated to Dickens, in the form of prefaces and afterwords accompanying the translations of his books. In the inter-war years, Dickens was perceived as the great humanist, romanticist, and critic of the social evils of the Victorian England; he was glori­fied for his Christian ethics and his ‘Christmas phi­losophy’ with the focus on goodness and ‘religion of the heart’, with his cult of fireside tranquility. In the Soviet period, it is important to stress the tremen­dous influence of Marxist and communist ideology on the reception of Dickens who was favoured by the Marxist critics. In his writing they found the suit­able object to dissect using the tools, whatever blunt, of the Marxist approach, which was the only possi­ble method of literary analysis in Soviet times.Thus, during the period of Soviet occupation, Dickens was perceived as a typical representative of the social novel and of critical realism in English literature. His novels were popular because of political and social implications; he was the most translated and celebrated of English authors as providing a critique of capitalist society. This communist and Marxist bias was a crucial factor

  12. ANA as part of a comprehensive reading literacy school assessment ...

    African Journals Online (AJOL)

    The purpose of this article is to report on the results of an exploratory action research study that indicate that the Annual National Assessment is overstepping its boundaries in terms of supporting the development of a systematic, dynamic and effective reading literacy assessment system to address the early literacy skills of ...

  13. Assessing the ability of Salmonella enterica to translocate Type III effectors into plant cells

    Science.gov (United States)

    Salmonella enterica, a human enteric pathogen, has the ability to multiply and survive endophytically in plants, and mutations in genes encoding the type III secretion system (T3SS) or its effectors (T3Es) may contribute to this colonization. Two reporter plasmids for T3E translocation into plant ce...

  14. Enhanced FAA-Hybrid III dummy for aircraft occupant safety assessment

    NARCIS (Netherlands)

    Waagmeester, C.D.; Ratingen, M.R. van; Giavotto, V.; Notarnicola, L.; Goldner, S.

    2002-01-01

    Following an integral approach unique in aircraft safety, the European HeliSafe project aims to improve the survivability of helicopter crashes and to reduce the risk at injuries for occupants in cockpit and cabin. In the project, a modified FAA-Hybrid III is used for the baseline-, design- and

  15. Enhanced FAA-hybrid III numerical dummy model in Madymo for aircraft occupant safety assessment

    NARCIS (Netherlands)

    Boucher, H.; Waagmeester, C.D.

    2003-01-01

    To improve survivability and to minimize the risk of injury to occupants in helicopter crash events, a complete Cabin Safety System concept including safety features and an enhanced FAA-Hybrid III dummy were developed within the HeliSafe project. A numerical tool was also created and validated to

  16. Dynamic assessment with the Bayley-III among young children with developmental disabilities

    NARCIS (Netherlands)

    Visser, Linda; Ruiter, Selma A.J>; van der Meulen, Bieuwe F.; Ruijssenaars, Wied A.J.J.M.; Timmerman, Marieke E.

    2015-01-01

    This article describes the results of a pilot study into the newly developed dynamic version of the Bayley-III Cognition scale. We explored the responses of children to the dynamic version (n 5 57) and the companion task behavior questionnaire (n 5 93) using administrations among children with

  17. Cephalometric assessment of maxillary length in Serbian children with skeletal class III

    Directory of Open Access Journals (Sweden)

    Stojanović Zdenka

    2013-01-01

    Full Text Available Background/Aim. Malocclusion of skeletal class III is a complex irregularity of sagittal inter-jaw relationship, which is due to irregularities of sagittal position of one or both of the jaw bones, which is often associated with disproportionate ratio of their length. The aim of this study was to determine whether the length of the jaw of children with skeletal class III in the period of mixed dentition was changed. Methods. Fifty children with skeletal class III and the same number of those with skeletal class I, of both sexes, have been selected on the basis of cephalometric analysis of profile tele-x-ray of the head. All the children aged 6-12 had mixed dentition, and were divided according to sex and age into three subgroups within each group. The length of maxilla, mandible and cranial base were measured. Proportions among the lengths measured within each group were found and difference significance in the measured lengths and their proportions among groups and subgroups were evaluated. Results. The children with skeletal class III, compared with the findings in the control group, had significantly lower values of maxillary length, total maxillary length, as well as lower values of their lengths in proportion to lengths of the front or the total length of cranial base and in proportion to mandibular lengths (p < 0.05. Among the patients of different sexes, both in the test and the control group, a significant difference in the values of the measured lengths was found. Conclusion. The children with skeletal class III have significantly shorter maxilla than those with skeletal class I.

  18. Balancing Optimal Assessment with Part-Time Faculty Participation: A Discipline's Dilemma

    Science.gov (United States)

    Danley-Scott, Jennifer; Tompsett-Makin, Deborah

    2013-01-01

    Part-time faculty need to be brought into the student learning outcomes assessment loop not only to help accreditation, but because they, like full-time faculty, can benefit from assessment. When part-time faculty are not participating in assessment, a sizable percentage of courses are being less effectively taught than they could be. In an…

  19. Bonding interactions and stability assessment of biopolymer material prepared using type III collagen of avian intestine and anionic polysaccharides.

    Science.gov (United States)

    Sailakshmi, G; Mitra, Tapas; Gnanamani, A; Kumara Raja, S Thirupathy; Thiruselvi, T; Selvaraj, Naga Vignesh; Ramesh, Gopal; Mandal, A B

    2011-06-01

    The present study demonstrate bonding interactions between anionic polysaccharides, alginic acid (AA) and type III collagen extracted from avian intestine used for the preparation of thermally stable and biodegradable biopolymer material. Further the study describes, optimum conditions (pH, temperature and NaCl concentration) required for the formation of fibrils in type III collagen, assessment on degree of cross-linking, nature of bonding patterns, biocompatibility and biodegradability of the cross-linked biomaterial. Results revealed, the resultant biopolymer material exhibit high thermal stability with 5-6 fold increase in tensile strength compared to the plain AA and collagen materials. The degree of cross-linking was calculated as 75%. No cytotoxicity was observed for the cross-linked biopolymer material when tested with skin fibroblast cells and the material was biodegradable when treated with enzyme collagenase. With reference to bonding pattern analysis we found, AA cross-linked with type III collagen via (i) formation of covalent amide linkage between -COOH group of AA and ε-NH₂ group of type-III collagen as well as (ii) intermolecular multiple hydrogen bonding between alginic acid -OH group with various amino acid functional group of type-III collagen. Comparisons were made with other cross-linking agents also. For better understanding of bonding pattern, bioinformatics analysis was carried out and discussed in detail. The results of the study emphasize, AA acts as a suitable natural cross-linker for the preparation of wound dressing biopolymer material using collagen. The tensile strength and the thermal stability further added value to the resultant biopolymer.

  20. Pipeline external corrosion direct assessment methodology: lessons learned - part 1

    Energy Technology Data Exchange (ETDEWEB)

    Kowalski, Angel R. [DNV Columbus, Inc., OH (United States)

    2009-07-01

    DNV Columbus (Former CC Technologies) played a key role in the development of Direct Assessment (DA) methodologies, providing leadership in the NACE technical committees charged with development of DA standards. Since the first publication of NACE Standard RP-0502-2002, External Corrosion Direct Assessment (ECDA) has been successfully applied over a great number of pipelines to evaluate the impact of external corrosion on the pipeline integrity. This paper summarizes the results of applying ECDA over a selected number of underground pipelines and presents interesting facts about the methodology. (author)

  1. Feasibility of Using Microsoft Kinect to Assess Upper Limb Movement in Type III Spinal Muscular Atrophy Patients.

    Directory of Open Access Journals (Sweden)

    Xing Chen

    Full Text Available Although functional rating scales are being used increasingly as primary outcome measures in spinal muscular atrophy (SMA, sensitive and objective assessment of early-stage disease progression and drug efficacy remains challenging. We have developed a game based on the Microsoft Kinect sensor, specifically designed to measure active upper limb movement. An explorative study was conducted to determine the feasibility of this new tool in 18 ambulant SMA type III patients and 19 age- and gender-matched healthy controls. Upper limb movement was analysed elaborately through derived features such as elbow flexion and extension angles, arm lifting angle, velocity and acceleration. No significant differences were found in the active range of motion between ambulant SMA type III patients and controls. Hand velocity was found to be different but further validation is necessary. This study presents an important step in the process of designing and handling digital biomarkers as complementary outcome measures for clinical trials.

  2. Complex Moving Parts: Assessment Systems and Electronic Portfolios

    Science.gov (United States)

    Larkin, Martha J.; Robertson, Royce L.

    2013-01-01

    The largest college within an online university of over 50,000 students invested significant resources in translating a complex assessment system focused on continuous improvement and national accreditation into an effective and efficient electronic portfolio (ePortfolio). The team building the system needed a model to address problems met…

  3. River Pollution: Part II. Biological Methods for Assessing Water Quality.

    Science.gov (United States)

    Openshaw, Peter

    1984-01-01

    Discusses methods used in the biological assessment of river quality and such indicators of clean and polluted waters as the Trent Biotic Index, Chandler Score System, and species diversity indexes. Includes a summary of a river classification scheme based on quality criteria related to water use. (JN)

  4. Assessment of Slat Noise Predictions for 30P30N High-Lift Configuration From BANC-III Workshop

    Science.gov (United States)

    Choudhari, Meelan; Lockard, David P.

    2015-01-01

    This paper presents a summary of the computational predictions and measurement data contributed to Category 7 of the 3rd AIAA Workshop on Benchmark Problems for Airframe Noise Computations (BANC-III), which was held in Atlanta, GA, on June 14-15, 2014. Category 7 represents the first slat-noise configuration to be investigated under the BANC series of workshops, namely, the 30P30N two-dimensional high-lift model (with a slat contour that was slightly modified to enable unsteady pressure measurements) at an angle of attack that is relevant to approach conditions. Originally developed for a CFD challenge workshop to assess computational fluid dynamics techniques for steady high-lift predictions, the 30P30N configurations has provided a valuable opportunity for the airframe noise community to collectively assess and advance the computational and experimental techniques for slat noise. The contributed solutions are compared with each other as well as with the initial measurements that became available just prior to the BANC-III Workshop. Specific features of a number of computational solutions on the finer grids compare reasonably well with the initial measurements from FSU and JAXA facilities and/or with each other. However, no single solution (or a subset of solutions) could be identified as clearly superior to the remaining solutions. Grid sensitivity studies presented by multiple BANC-III participants demonstrated a relatively consistent trend of reduced surface pressure fluctuations, higher levels of turbulent kinetic energy in the flow, and lower levels of both narrow band peaks and the broadband component of unsteady pressure spectra in the nearfield and farfield. The lessons learned from the BANC-III contributions have been used to identify improvements to the problem statement for future Category-7 investigations.

  5. Is extreme learning machine feasible? A theoretical assessment (part I).

    Science.gov (United States)

    Liu, Xia; Lin, Shaobo; Fang, Jian; Xu, Zongben

    2015-01-01

    An extreme learning machine (ELM) is a feedforward neural network (FNN) like learning system whose connections with output neurons are adjustable, while the connections with and within hidden neurons are randomly fixed. Numerous applications have demonstrated the feasibility and high efficiency of ELM-like systems. It has, however, been open if this is true for any general applications. In this two-part paper, we conduct a comprehensive feasibility analysis of ELM. In Part I, we provide an answer to the question by theoretically justifying the following: 1) for some suitable activation functions, such as polynomials, Nadaraya-Watson and sigmoid functions, the ELM-like systems can attain the theoretical generalization bound of the FNNs with all connections adjusted, i.e., they do not degrade the generalization capability of the FNNs even when the connections with and within hidden neurons are randomly fixed; 2) the number of hidden neurons needed for an ELM-like system to achieve the theoretical bound can be estimated; and 3) whenever the activation function is taken as polynomial, the deduced hidden layer output matrix is of full column-rank, therefore the generalized inverse technique can be efficiently applied to yield the solution of an ELM-like system, and, furthermore, for the nonpolynomial case, the Tikhonov regularization can be applied to guarantee the weak regularity while not sacrificing the generalization capability. In Part II, however, we reveal a different aspect of the feasibility of ELM: there also exists some activation functions, which makes the corresponding ELM degrade the generalization capability. The obtained results underlie the feasibility and efficiency of ELM-like systems, and yield various generalizations and improvements of the systems as well.

  6. Probabilistic seismic hazard assessment in Greece – Part 3: Deaggregation

    Directory of Open Access Journals (Sweden)

    G-A. Tselentis

    2010-01-01

    Full Text Available The present third part of the study, concerning the evaluation of earthquake hazard in Greece in terms of various ground motion parameters, deals with the deaggregation of the obtained results The seismic hazard maps presented for peak ground acceleration and spectral acceleration at 0.2 s and 1.0 s, with 10% probability of exceedance in 50 years, were deaggregated in order to quantify the dominant scenario. There are three basic components of each dominant scenario: earthquake magnitude (M, source-to-site distance (R and epsilon (ε. We present deaggregation maps of mean and mode values of M-R-ε triplet showing the contribution to hazard over a dense grid.

  7. Schinus terebinthifolius countercurrent chromatography (Part III): Method transfer from small countercurrent chromatography column to preparative centrifugal partition chromatography ones as a part of method development.

    Science.gov (United States)

    das Neves Costa, Fernanda; Hubert, Jane; Borie, Nicolas; Kotland, Alexis; Hewitson, Peter; Ignatova, Svetlana; Renault, Jean-Hugues

    2017-03-03

    Countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC) are support free liquid-liquid chromatography techniques sharing the same basic principles and features. Method transfer has previously been demonstrated for both techniques but never from one to another. This study aimed to show such a feasibility using fractionation of Schinus terebinthifolius berries dichloromethane extract as a case study. Heptane - ethyl acetate - methanol -water (6:1:6:1, v/v/v/v) was used as solvent system with masticadienonic and 3β-masticadienolic acids as target compounds. The optimized separation methodology previously described in Part I and II, was scaled up from an analytical hydrodynamic CCC column (17.4mL) to preparative hydrostatic CPC instruments (250mL and 303mL) as a part of method development. Flow-rate and sample loading were further optimized on CPC. Mobile phase linear velocity is suggested as a transfer invariant parameter if the CPC column contains sufficient number of partition cells. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Normal and sonographic anatomy of selected peripheral nerves. Part III: Peripheral nerves of the lower limb

    Directory of Open Access Journals (Sweden)

    Berta Kowalska

    2012-06-01

    Full Text Available The ultrasonographic examination is currently increasingly used in imaging peripheral nerves, serving to supplement the physical examination, electromyography and magnetic resonance imaging. As in the case of other USG imaging studies, the examination of peripheral nerves is non-invasive and well-tolerated by patients. The typical ultrasonographic picture of peripheral nerves as well as the examination technique have been discussed in part I of this article series, following the example of the median nerve. Part II of the series presented the normal anatomy and the technique for examining the peripheral nerves of the upper limb. This part of the article series focuses on the anatomy and technique for examining twelve normal peripheral nerves of the lower extremity: the iliohypogastric and ilioinguinal nerves, the lateral cutaneous nerve of the thigh, the pudendal, sciatic, tibial, sural, medial plantar, lateral plantar, common peroneal, deep peroneal and superficial peroneal nerves. It includes diagrams showing the proper positioning of the sonographic probe, plus USG images of the successively discussed nerves and their surrounding structures. The ultrasonographic appearance of the peripheral nerves in the lower limb is identical to the nerves in the upper limb. However, when imaging the lower extremity, convex probes are more often utilized, to capture deeply-seated nerves. The examination technique, similarly to that used in visualizing the nerves of upper extremity, consists of locating the nerve at a characteristic anatomic reference point and tracking it using the “elevator technique”. All 3 parts of the article series should serve as an introduction to a discussion of peripheral nerve pathologies, which will be presented in subsequent issues of the “Journal of Ultrasonography”.

  9. From University to Work III Part 1 : Sociological Mechanisms of Determinants of Job Opportunities for Non-Selective College Students

    OpenAIRE

    苅谷, 剛彦; 平沢, 和司; 本田, 由紀; 中村, 高康; 小山, 治

    2007-01-01

    During 1990s, job markets for university graduates faced drastic changes. On the one hand, the number of appropriate jobs for college graduates reduced greatly. Part time or temporal jobs increased and the number of graduates who had no jobs upon graduation increased. On the other hand, the supply side of new school graduates'job market changed. The main source of supply became college and university graduates because the number of work-bound high school graduates reduced and college-bound st...

  10. Protocol Outlines for Parts 1 and 2 of the Prospective Endoscopy III Study for the Early Detection of Colorectal Cancer

    DEFF Research Database (Denmark)

    Rasmussen, Louise; Wilhelmsen, Michael; Christensen, Ib Jarle

    2016-01-01

    concepts, particularly when combinations of the various components appear to lead to significant improvements. OBJECTIVES: The protocol described in this paper focuses on the validation of concepts based on biomarkers in blood in a major population screened by FIT. METHODS: In Part 1, participants...... sensitivity for detection of participants with non-symptomatic CRC. Therefore, research approaches have been initiated to develop screening concepts based on biomarkers in blood. Preliminary results show that protein, genetic, epigenetic, and metabolomic components may be valuable in blood-based screening...

  11. Taxonomy of 'Euconnus complex'. Part III. Morphology of Euconnus subgenus Napochus and revision of the Australian species (Coleoptera, Staphylinidae, Scydmaeninae).

    Science.gov (United States)

    Jałoszyński, Paweł

    2015-02-26

    Morphological structures of the type species of Euconnus (Napochus) are described and illustrated, and compared with those of Euconnus s. str. Napochus is maintained as a subgenus of Euconnus, and its revised diagnosis is given. Australian species of Napochus are revised: E. palmwoodianus Franz and E. pisoniae Franz are redescribed, and E. setiphallus sp. n., E. yadhaigana sp. n., E. microlaminatus sp. n, E. feeneyi sp. n. (with a subspecies E. feeneyi parallelilaminatus ssp. n.) are described. An unusual variability in body size and proportions of body parts found in E. feeneyi is analyzed and discussed.

  12. Is extreme learning machine feasible? A theoretical assessment (part II).

    Science.gov (United States)

    Lin, Shaobo; Liu, Xia; Fang, Jian; Xu, Zongben

    2015-01-01

    An extreme learning machine (ELM) can be regarded as a two-stage feed-forward neural network (FNN) learning system that randomly assigns the connections with and within hidden neurons in the first stage and tunes the connections with output neurons in the second stage. Therefore, ELM training is essentially a linear learning problem, which significantly reduces the computational burden. Numerous applications show that such a computation burden reduction does not degrade the generalization capability. It has, however, been open that whether this is true in theory. The aim of this paper is to study the theoretical feasibility of ELM by analyzing the pros and cons of ELM. In the previous part of this topic, we pointed out that via appropriately selected activation functions, ELM does not degrade the generalization capability in the sense of expectation. In this paper, we launch the study in a different direction and show that the randomness of ELM also leads to certain negative consequences. On one hand, we find that the randomness causes an additional uncertainty problem of ELM, both in approximation and learning. On the other hand, we theoretically justify that there also exist activation functions such that the corresponding ELM degrades the generalization capability. In particular, we prove that the generalization capability of ELM with Gaussian kernel is essentially worse than that of FNN with Gaussian kernel. To facilitate the use of ELM, we also provide a remedy to such a degradation. We find that the well-developed coefficient regularization technique can essentially improve the generalization capability. The obtained results reveal the essential characteristic of ELM in a certain sense and give theoretical guidance concerning how to use ELM.

  13. Macro-mechanical modeling of blast-wave mitigation in foams. Part III: verification of the models

    Science.gov (United States)

    Britan, A.; Shapiro, H.; Liverts, M.; Ben-Dor, G.

    2014-05-01

    Three different approaches to macro-mechanical modeling of blast-wave mitigation in foam namely: the single-phase effective gas flow model, the two-phase mixture model and the single bubble/shock wave interaction model are critically reviewed. The nature and extent of the approximations inherent in the formulation of the first two models were examined in Part I of this study. In this part, the applicability of the aforementioned approaches is verified based on a comparison of experimental pressure records obtained in shock tube tests with the results of numerical predictions that used the models under consideration. Deficiencies and inconsistencies that are found during this comparison are clarified and possible improvements are suggested. It is emphasized that both the single-phase and the two-phase approaches predict well the refraction of the incident shock at the air/foam interface while they do not uniquely determine the relaxation process and the shape of the transmitted shock wave front. Various flexibilities that are exploited to better describe the inter-phase interactions do not improve the results significantly. The single bubble model is examined with particular attention paid to the manner in which it predicts the shape of the shock wave front. Connections between the flow viscosity and the transient dynamics of the bubble compression that occur at scales of the shock wave front thickness are explored.

  14. Metal-ligand interaction of lanthanides with coumarin derivatives. Part I. Complexation of 3-(1-aminoethylidene)-2H-chromene-2,4(3H)-dione with La(III), Ce(III), Nd(III) and Ho(III).

    Science.gov (United States)

    Swiatek, Mirosława; Kufelnicki, Aleksander

    2012-01-01

    Solutions of lanthanum(III), cerium(III), neodymium(III) and holmium(III) nitrates with 3-(1-aminoethylidene)-2H-chromene-2,4(3H)-dione (1) in 10% v/v dioxane-water medium were used. Coordination modes of 1 with the selected lanthanides have been examined. Hydroxo-complexes with deprotonated water molecules from the inner coordination sphere have been stated in basic medium. Stability constants of the forming complex species were determined by potentiometric titrations using Superquad and Hyperquad2003 programs. The most stable complexes are formed with La(III). The UV-Vis spectra of the Nd(III)-1 system confirmed the L:M = 1:1 stoichiometry evaluated potentiometrically.

  15. Psychometric evaluation of the Brachial Assessment Tool Part 1: Reproducibility.

    Science.gov (United States)

    Grad, Bridget Hill; Williams, Gavin; Olver, John; Ferris, Scott; Bialocerkowski, Andrea

    2017-11-06

    To evaluate reproducibility (reliability and agreement) of the Brachial Assessment Tool (BrAT) a new patient-reported outcome measure for adults with traumatic Brachial Plexus Injury (BPI) DESIGN: Prospective repeated measure design SETTING: Outpatient clinics PARTICIPANTS: Adults with confirmed traumatic BPI INTERVENTION: 43 people (age range 19-82) with BPI completed the 31-item 4-response BrAT twice, 2 weeks apart. Results for the 3 subscales and summed score were compared at time 1 and time 2 to determine reliability including systematic differences using paired t tests; test retest using Intraclass Correlation Coefficient (ICC 1,1) and internal consistency using Cronbach alpha. Agreement parameters included standard error of measurement, minimal detectable change and limits of agreement. The BrAT RESULTS: Test retest reliability was excellent (ICC [1,1] = 0.90 - 0.97). Internal consistency was high (Cronbach alpha 0.90 - 0.98). Measurement error was relatively low (SEM range 3.1 - 8.8). A change of >4 for subscale 1, >6 for subscale 2, >4 for subscale 3 and >10 for the summed score is indicative of change over and above measurement error. Limits of agreement ranged from ± 4.4 (subscale 3) to 11.61 (summed score). These findings support the use of the BrAT as a reproducible patient reported outcome measure for adults with traumatic BPI with evidence of appropriate reliability and agreement for both individual and group comparisons. Further psychometric testing is required to establish the construct validity and responsiveness of the BrAT. Copyright © 2017. Published by Elsevier Inc.

  16. Illustrated Imaging Essay on Congenital Heart Diseases: Multimodality Approach Part III: Cyanotic Heart Diseases and Complex Congenital Anomalies.

    Science.gov (United States)

    Bhat, Venkatraman; Belaval, Vinay; Gadabanahalli, Karthik; Raj, Vimal; Shah, Sejal

    2016-07-01

    From the stand point of radiographic analysis most of the complex cyanotic congenital heart diseases (CHD), can be divided into those associated with decreased or increased pulmonary vascularity. Combination of a specific cardiac configuration and status of lung vasculature in a clinical context allows plain film diagnosis to be predicted in some CHD. Correlation of the position of the cardiac apex in relation to the visceral situs is an important information that can be obtained from the plain film. This information helps in gathering information about the atrio-ventricular, ventricular arterial concordance or discordance. Categorization of the cyanotic heart disease based on vascularity is presented below. Thorough understanding of cardiac anatomy by different imaging methods is essential in understanding and interpreting complex cardiac disease. Basic anatomical details and background for interpretation are provided in the previous parts of this presentation.

  17. Study of irradiated bone: Part III. /sup 99m/Tc pyrophosphate autoradiographic changes. [X rays; rabbits

    Energy Technology Data Exchange (ETDEWEB)

    King, M.A.; Corriveau, O.; Casarett, G.W.; Weber, D.A.

    1978-01-01

    The macroautoradiographic and microautoradiographic localization of /sup 99m/Tc-pyrophosphate (/sup 99m/TcPPi) was studied in x-irradiated bone of rabbits up to one year post-irradiation. In cortical bone, /sup 99m/TcPPi was concentrated on bone surfaces near vasculature. Both forming and resorbing bone surfaces were comparably labeled at 2 hrs post-injection. Uptake on the surface of sites of haversian bone remodeling was observed to be at least part of the increased /sup 99m/TcPPi observed in irradiated bone in camera images. In irradiated trabecular bone 12 months following irradiation, a patchy decrease in /sup 99m/TcPPi uptake was correlated with localized decreases in vasculature.

  18. Associations and communities of cereal crops of the Łuków Plain. Part III. Intermediate and impoverished communities

    Directory of Open Access Journals (Sweden)

    Zofia Rzymowska

    2015-01-01

    Full Text Available This paper is the third and final part of a study attempting to analyse associations and communities in cereal crops of the Łuków Plain. It contains a description of intermediate and impoverished communities established in cereal crops of the Łuków Plain. Patches with phytocenoses without the combination of species characteristic of cereal associations were frequently observed. Impoverished communities of the alliance Aperion spicae-venti established in winter cereal crops. In turn, in spring cereal crops phytocenoses including species characteristic of tuber and root crops were found; they represented either a community with species characteristic of Panico-Setarion or an intermediate community with species characteristic of Aperion spicae-venti and Polygono-Chenopodion. Such communities are established, among others, because of production intensification which changes habitat conditions. Some patches found in the study area were intermediate between the two most frequently observed associations Arnoserido-Scleranthetum and Vicietum tetraspermae.

  19. Pantoea agglomerans: a mysterious bacterium of evil and good. Part III. Deleterious effects: infections of humans, animals and plants

    Directory of Open Access Journals (Sweden)

    Jacek Dutkiewicz

    2016-06-01

    plant called Chinese taro ([i]Alocasia cucullata[/i], and a grass called onion couch ([i]Arrhenatherum elatius[/i]. Some plant-pathogenic strains of [i]P. agglomerans[/i] are tumourigenic, inducing gall formation on table beet, an ornamental plant gypsophila ([i]Gypsophila paniculata[/i], wisteria, Douglas-fir and cranberry. Recently, a [i]Pantoea[/i] species closely related to [i]P. agglomerans[/i] has been identified as a cause of bacterial blight disease in the edible mushroom [i]Pleurotus eryngii[/i] cultivated in China. The genetically governed determinants of plant pathogenicity in [i]Pantoea agglomerans[/i] include such mechanisms as the hypersensitive response and pathogenicity (hrp system, phytohormones, the quorum-sensing (QS feedback system and type III secretion system (T3SS injecting the effector proteins into the cytosol of a plant cell.

  20. Orthodontic decompensation in skeletal Class III malocclusion: redefining the amount of movement assessed by Cone-Beam Computed Tomography

    Directory of Open Access Journals (Sweden)

    José Antonio Zuega Cappellozza

    2015-10-01

    Full Text Available Introduction:Cone-Beam Computed Tomography (CBCT is essential for tridimensional planning of orthognathic surgery, as it allows visualization and evaluation of bone structures and mineralized tissues. Tomographic slices allow evaluation of tooth inclination and individualization of movement performed during preoperative decompensation. The aim of this paper was to assess maxillary and mandibular incisors inclination pre and post orthodontic decompensation in skeletal Class III malocclusion.Methods:The study was conducted on six individuals with skeletal Class III malocclusion, surgically treated, who had Cone-Beam Computed Tomographic scans obtained before and after orthodontic decompensation. On multiplanar reconstruction view, tomographic slices (axial, coronal and sagittal were obtained on the long axis of each incisor. The sagittal slice was used for measurement taking, whereas the references used to assess tooth inclination were the long axis of maxillary teeth in relation to the palatal plane and the long axis of mandibular teeth in relation to the mandibular plane.Results:There was significant variation in the inclination of incisors before and after orthodontic decompensation. This change was of greater magnitude in the mandibular arch, evidencing that natural compensation is more effective in this arch, thereby requiring more intensive decompensation.Conclusion:When routinely performed, the protocols of decompensation treatment in surgical individuals often result in intensive movements, which should be reevaluated, since the extent of movement predisposes to reduction in bone attachment levels and root length.

  1. Use of rumination and activity monitoring for the identification of dairy cows with health disorders: Part III. Metritis.

    Science.gov (United States)

    Stangaferro, M L; Wijma, R; Caixeta, L S; Al-Abri, M A; Giordano, J O

    2016-09-01

    The objectives of this study were to evaluate (1) the performance of an automated health-monitoring system (AHMS) to identify cows with metritis based on an alert system (health index score, HIS) that combines rumination time and physical activity; (2) the number of days between the first HIS alert and clinical diagnosis (CD) of metritis by farm personnel; and (3) the daily rumination time, physical activity, and HIS patterns around CD. In this manuscript, the overall performance of HIS to detect cows with all disorders of interest in this study [ketosis, displaced abomasum, indigestion (companion paper, part I), mastitis (companion paper, part II), and metritis] is also reported. Holstein cattle (n=1,121; 451 nulliparous and 670 multiparous) were fitted with a neck-mounted electronic rumination and activity monitoring tag (HR Tags, SCR Dairy, Netanya, Israel) from at least -21 to 80 d in milk (DIM). Raw data collected in 2-h periods were summarized per 24 h as daily rumination and activity. An HIS (0 to 100 arbitrary units) was calculated daily for individual cows with an algorithm that used rumination and activity. A positive HIS outcome was defined as an HIS of cows (n=459) at -11±3, -4±3, 0, 3±1, 7±1, 14±1, and 28±1 DIM. The overall sensitivity of HIS was 55% for all cases of metritis (n=349), but it was greater for cows with metritis and another disorder (78%) than for cows with metritis only (53%). Cows diagnosed with metritis and flagged based on HIS had substantial alterations in their rumination, activity, and HIS patterns around CD, alterations of blood markers of metabolic and health status around calving, reduced milk production, and were more likely to exit the herd than cows not flagged based on the HIS and cows without disease, suggesting that cows flagged based on the HIS had a more severe episode of metritis. Including all disorders of interest for this study, the overall sensitivity was 59%, specificity was 98%, positive predictive value was

  2. Controlled production of camembert-type cheeses: part III role of the ripening microflora on free fatty acid concentrations.

    Science.gov (United States)

    Leclercq-Perlat, Marie-Noëlle; Corrieu, Georges; Spinnler, Henry-Eric

    2007-05-01

    Phenomena generating FFAs, important flavour precursors, are significant in cheese ripening. In Camembert-like cheeses, it was intended to establish the relationships between the dynamics of FFA concentrations changes and the succession of ripening microflora during ripening. Experimental Camembert-type cheeses were prepared in duplicate from pasteurised milk inoculated with Kluyveromyces lactis, Geotrichum candidum, Penicillium camemberti, and Brevibacterium aurantiacum under aseptic conditions. For each cheese and each cheesy medium, concentrations of FFAs with odd-numbered carbons, except for 9:0 and 13:0, did not change over time. For long-chain FFAs, concentrations varied with the given cheese part (rind or core). K. lactis produced only short or medium-chain FFAs during its growth and had a minor influence on caproic, caprylic, capric, and lauric acids in comparison with G. candidum, the most lipolytic of the strains used here. It generated all short or medium-chain FFAs (4:0-12:0) during its exponential and slowdown growth periods and only long-chain ones (14:0-18:0) during its stationary phase. Pen. camemberti produced more long-chain FFAs (14:0-18:0) during its sporulation. Brev. aurantiacum did not generate any FFAs. The evidence of links between specific FFAs and the growth of a given microorganism is shown.

  3. Prevention of infection in patients with chronic kidney disease part III: surveillance and auditing in a renal care environment.

    Science.gov (United States)

    Donlon, Sheila; Redmond, Avril; McCann, Margaret; Einarsdottir, Hildur

    2011-09-01

    This third paper, in a three-part CE series on the preventions of infection in patients with chronic kidney disease, focuses on surveillance and auditing of healthcare-associated infections within the renal care environment. The last decade has seen an increased awareness of the threat to patient safety from healthcare-associated infection (HCAI) and the emergence of multi-drug resistance organisms. Effective HCAI prevention strategies include adequate governance structures, access to expert advice, adherence to standard and transmission-based precautions, minimising the use of invasive medical devices, and surveillance. Surveillance data can be collected using outcome (e.g. infection) and/or process (e.g. hand hygiene compliance audit) measures. Establishing a surveillance programme requires: commitment from senior management and the multidisciplinary team, prompt feedback of the data to clinical managers resulting in action been taken if necessary, to address specific areas of concern. While many renal units have access to infection prevention and control expertise to assist in the development of such a programme, units without such expertise should also have a surveillance programme in place. © 2011 European Dialysis and Transplant Nurses Association/European Renal Care Association.

  4. Australian Assassins, Part III: A review of the Assassin Spiders (Araneae, Archaeidae) of tropical north-eastern Queensland.

    Science.gov (United States)

    Rix, Michael G; Harvey, Mark S

    2012-01-01

    The assassin spiders of the family Archaeidae from tropical north-eastern Queensland are revised, with eight new species described from rainforest habitats of the Wet Tropics bioregion and Mackay-Whitsundays Hinterland: Austrarchaea griswoldisp. n., Austrarchaea hoskinisp. n., Austrarchaea karenaesp. n., Austrarchaea tealeisp. n., Austrarchaea thompsonisp. n., Austrarchaea wallaceisp. n., Austrarchaea westisp. n. and Austrarchaea woodaesp. n. Specimens of the only previously described species, Austrarchaea daviesae Forster & Platnick, 1984, are redescribed from the southern Atherton Tableland. The rainforests of tropical eastern Queensland are found to be a potential hotspot of archaeid diversity and endemism, with the region likely to be home to numerous additional short-range endemic taxa. A key to species complements the taxonomy, with maps, natural history information and conservation assessments provided for all species.

  5. Australian Assassins, Part III: A review of the Assassin Spiders (Araneae, Archaeidae of tropical north-eastern Queensland

    Directory of Open Access Journals (Sweden)

    Michael Rix

    2012-08-01

    Full Text Available The assassin spiders of the family Archaeidae from tropical north-eastern Queensland are revised, with eight new species described from rainforest habitats of the Wet Tropics bioregion and Mackay-Whitsundays Hinterland: A. griswoldi sp. n., A. hoskini sp. n., A. karenae sp. n., A. tealei sp. n., A. thompsoni sp.n., A. wallacei sp. n., A. westi sp. n. and A. woodae sp. n. Specimens of the only previously described species, A. daviesae Forster & Platnick, 1984, are redescribed from the southern Atherton Tableland. The rainforests of tropical eastern Queensland are found to be a potential hotspot of archaeid diversity and endemism, with the region likely to be home to numerous additional short-range endemic taxa. A key to species complements the taxonomy, with maps, natural history information and conservation assessments provided for all species.

  6. Coastal circulation and sediment dynamics in Hanalei Bay, Kaua'i, Hawaii, part III, studies of sediment toxicity

    Science.gov (United States)

    Carr, Robert S.; Nipper, Marion; Field, Michael; Biedenbach, James M.

    2006-01-01

    Toxicity tests are commonly conducted as a measure of the bioavailability of toxic chemicals to biota in an environment. Chemical analyses alone are insufficient to determine whether contaminants pose a threat to biota. Porewater toxicity tests are extremely sensitive to a broad range of contaminants in marine environments and provide ecologically relevant data on sensitive life stages. The inclusion of porewater toxicity testing as an additional indicator of sediment quality provides a more comprehensive picture of contaminant effects in these sensitive habitats. In this study purple-spined sea urchin (Arbacia punctulata) fertilization and embryological development porewater toxicity tests were used to evaluate the sediments collected from the coastal environment around Hanalei Bay, Kaua’i, Hawaii. These tests have been used previously to assess the bioavailability of contaminants associated with sediments in the vicinity of coral reefs.

  7. 38 CFR Appendix B to Part 200 - The Action Requiring an Environmental Assessment

    Science.gov (United States)

    2010-07-01

    ... Environmental Assessment B Appendix B to Part 200 Pensions, Bonuses, and Veterans' Relief ARMED FORCES...—The Action Requiring an Environmental Assessment The following actions are not considered to be major... and would require the preparation of an Environmental Assessment (EA): B.1Construction on previously...

  8. An assessment of the response of Military lower extremity and Hybrid III leg during typical blast impact using the Hybrid III and EUROSID-2 ATD.

    CSIR Research Space (South Africa)

    Pandelani, T

    2014-09-01

    Full Text Available This paper presents the evaluation of the injury measurement response of the Hybrid III and ES2re ATD’s using both the HIII and MiL-Lx instrumented lower legs as loaded by the Modified Lower Limb Impactor (MLLI)....

  9. "Why Not Stoichiometry" versus "Stoichiometry—Why Not?" Part III: Extension of GATES/GEB on Complex Dynamic Redox Systems.

    Science.gov (United States)

    Michałowska-Kaczmarczyk, Anna M; Michałowski, Tadeusz; Toporek, Marcin; Asuero, Agustin G

    2015-01-01

    In the third part of a series of articles issued under a common title, some examples of complex dynamic redox systems are presented and considered from analytical and physico-chemical viewpoints; the analysis is a leitmotiv for detailed, physico-chemical considerations. All attainable physico-chemical knowledge is involved in algorithms applied for resolution of the systems, realized with use of iterative computer programs. The first redox system (System I) is related to titration of FeSO4 + H2C2O4 with KMnO4 solution in acidic (H2SO4) medium, where simultaneous determination of both analytes from a single curve of potentiometric titration is possible. The possibility of the formation of precipitates (FeC2O4 and/or MnC2O4) in this system is taken into considerations. The second system (System II) relates to the complete analytical procedure involved in the iodometric determination of Cu; four consecutive steps of this analysis are considered. As a reasonable tool for explanation of processes occurring during simulated redox titration, speciation diagrams are suggested. This explanation is based on graphical presentation of results obtained from the calculations. The calculations made for this purpose are performed in accordance with principles of the generalized approach to electrolytic systems (GATES) with generalized electron balance (GEB) or GATES/GEB and realized with use of iterative computer programs offered by MATLAB. The reactions proceeding in this system can be formulated, together with their efficiencies, at any stage of the titration. Stoichiometry is considered as the derivative concept when put in context with GATES/GEB. The article illustrates the enormous possibilities and advantages offered by GATES/GEB.

  10. Synthesis and antiproliferative activity of 3-aryl-2-(1H-benzotriazol-1-yl)acrylonitriles. Part III.

    Science.gov (United States)

    Carta, Antonio; Sanna, Paolo; Palomba, Michele; Vargiu, Laura; La Colla, Massimiliano; Loddo, Roberta

    2002-11-01

    A new series of 30 3-aryl-2-(1H-benzotriazol-1-yl)acrylonitriles were synthesized and tested for biological activity as part of our research in the antimicrobial and antitumor fields. In particular, title compounds were evaluated in vitro against representative strains of Gram-positive and Gram-negative bacteria (S. aureus, Salmonella spp), mycobacteria (M. fortuitum, M. smegmatis ATCC 19420 and M. tuberculosis ATCC 27294), yeast and mould (C. albicans ATCC 10231 and A. fumigatus). Furthermore, their antiretroviral activity against HIV-1 was determined in MT-4 cells together with cytotoxicity. In these assays title compounds and 47 additional derivatives described previously (P. Sanna, A. Carta, M.E. Rahbar Nikookar, Eur. J. Med. Chem. 35 (2000) 535-543; P. Sanna, A. Carta, L. Gherardini, M.E. Rahbar Nikookar, Farmaco 57 (2002) 79-87) were tested for their capability to prevent MT-4 cell growth. All compounds resulted devoid of antibacterial, antifungal and anti-HIV-1 activity. In anti-mycobacterial assays several compounds resulted active (MIC(50)=6.0-70 microM) against M. tuberculosis. However, since they showed cytotoxicity against MT-4 cells at lower concentrations (CC(50)=0.05-25 microM), their anti-mycobacterial activity was not selective. For this reason, the most cytotoxic compounds were also evaluated for antiproliferative activity against a panel of human cell lines derived from both hematological and solid tumors. Compound 34 resulted the most potent compound against the above human tumor-derived cell lines.

  11. Oral health assessment and mouth care for children and young people receiving palliative care. Part two.

    Science.gov (United States)

    Sargeant, S; Chamley, C

    2013-04-01

    This is the second part of a two-part article on oral health assessment and mouth care for children and young people receiving palliative care. This article covers basic oral hygiene and management of oral health problems: oral candidiasis, coated tongue/dirty mouth, dry mouth, hypersalivation, ulceration, painful mouth, stomatitis and mucositis. The article also covers treating patients who are immunocompromised and the need to educate families and carers in the basic principles of oral care, including the importance of preventing cross-infection. Part one outlined oral assessment and discussed the adaptation of the Nottingham Oral Health Assessment Tool (Freer 2000).

  12. Developing a spinal cord injury research strategy using a structured process of evidence review and stakeholder dialogue. Part III: outcomes.

    Science.gov (United States)

    Middleton, J W; Piccenna, L; Lindsay Gruen, R; Williams, S; Creasey, G; Dunlop, S; Brown, D; Batchelor, P E; Berlowitz, D J; Coates, S; Dunn, J A; Furness, J B; Galea, M P; Geraghty, T; Kwon, B K; Urquhart, S; Yates, D; Bragge, P

    2015-10-01

    Focus Group. To develop a unified, regional spinal cord injury (SCI) research strategy for Australia and New Zealand. Australia. A 1-day structured stakeholder dialogue was convened in 2013 in Melbourne, Australia, by the National Trauma Research Institute in collaboration with the SCI Network of Australia and New Zealand. Twenty-three experts participated, representing local and international research, clinical, consumer, advocacy, government policy and funding perspectives. Preparatory work synthesised evidence and articulated draft principles and options as a starting point for discussion. A regional SCI research strategy was proposed, whose objectives can be summarised under four themes. (1) Collaborative networks and strategic partnerships to increase efficiency, reduce duplication, build capacity and optimise research funding. (2) Research priority setting and coordination to manage competing studies. (3) Mechanisms for greater consumer engagement in research. (4) Resources and infrastructure to further develop SCI data registries, evaluate research translation and assess alignment of research strategy with stakeholder interests. These are consistent with contemporary international SCI research strategy development activities. This first step in a regional SCI research strategy has articulated objectives for further development by the wider SCI research community. The initiative has also reinforced the importance of coordinated, collective action in optimising outcomes following SCI.

  13. III: Use of biomarkers as Risk Indicators in Environmental Risk Assessment of oil based discharges offshore.

    Science.gov (United States)

    Sanni, Steinar; Lyng, Emily; Pampanin, Daniela M

    2017-06-01

    Offshore oil and gas activities are required not to cause adverse environmental effects, and risk based management has been established to meet environmental standards. In some risk assessment schemes, Risk Indicators (RIs) are parameters to monitor the development of risk affecting factors. RIs have not yet been established in the Environmental Risk Assessment procedures for management of oil based discharges offshore. This paper evaluates the usefulness of biomarkers as RIs, based on their properties, existing laboratory biomarker data and assessment methods. Data shows several correlations between oil concentrations and biomarker responses, and assessment principles exist that qualify biomarkers for integration into risk procedures. Different ways that these existing biomarkers and methods can be applied as RIs in a probabilistic risk assessment system when linked with whole organism responses are discussed. This can be a useful approach to integrate biomarkers into probabilistic risk assessment related to oil based discharges, representing a potential supplement to information that biomarkers already provide about environmental impact and risk related to these kind of discharges. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Culling of dairy cows. Part III. Effects of diseases, pregnancy status and milk yield on culling in Finnish Ayrshire cows.

    Science.gov (United States)

    Rajala-Schultz, P J; Gröhn, Y T

    1999-08-23

    The effects of 15 diseases, pregnancy status and milk yield on culling were studied in 39727 Finnish Ayrshire cows that calved in 1993 and were followed until culling or next calving. Survival analysis, using the Cox proportional hazards model, was performed with diseases, pregnancy status and milk yield as time-dependent covariates. Effects of parity, calving season and herd were also accounted for. Pregnancy status was the single most influential factor affecting culling decisions, followed by milk yield. Several diseases also had a significant effect on culling, the most influential ones being mastitis, lameness, teat injuries, and milk fever. The effects of all of these factors varied according to the stage of lactation. Milk yield had a significant effect on culling decisions, depending on the stage of lactation. At the beginning of lactation, milk production did not have any effect on culling decisions, but later on, the highest producers were at the lowest risk of being culled and the lowest producers had the highest risk. Adjusting for milk yield modified the effects of parity, most diseases and also pregnancy status on culling. Effects of parity increased after including milk yield in the model, indicating that milk yield and parity are interrelated in their effects on culling. The effects of pregnancy status also increased towards the end of lactation when milk yield was accounted for in the model. The effects of mastitis, teat injuries and lameness decreased after adjusting for milk production. These diseases lower milk yield and thus, part of their effect on culling was mediated through milk production. The effects of anestrus and ovarian cysts were mainly modified by pregnancy status, but not by milk yield. The effects of milk fever on culling increased at the beginning of lactation after including milk yield in the model. This suggests that even though cows with milk fever tend to be higher producers, it is the disease as such that triggers the

  15. Acute mental health care according to recent mental health legislation. Part III. Structuring space for acute mental health care.

    Science.gov (United States)

    Janse van Rensburg, A; Janse van Rensburg, A B R

    2011-05-01

    This is the third of three reports on the follow-up review of mental health care at Helen Joseph Hospital (HJH). The study reviewed existing South African standards for mental health care facilities. Architectural principles and implications for the use of space were deducted from recent legislation. Objectives were to evaluate the use of space in the existing physical facilities, to identify appropriate architectural solutions considering identified human rights requirements and to provide provisional cost estimates to align the unit towards its designated functions. Personal interviews were conducted. An on-site assessment and survey was made of existing and potential new spaces. Spatial requirements for implementing the Mental Health Act, No. 17 of 2002 (MHCA) were explored. Principles for spatial design of acute facilities include that: - spaces should communicate clear individual identity; - space should be segregated into zones according to user functionality and privacy; - communal leisure spaces should open into safe contained outdoor spaces; - circulation routes should preferably be circular; - sufficient visual connection should exist between circulation space and group activities; and - open lines of sight should be provided to all access points. The potential options for extension included: - an extensive unused single storey structural shell for a potential office wing on the same floor; - a huge vacant double volume space which could be accessed across the existing flat roof for potential occupational therapy activities; and - the existing roof area could be altered and secured to become an adequate outside leisure and garden area. A proposed concept design in two phases - based on these principles - was submitted to hospital and provincial management. To implement the MHCA without violating the human rights of mental health care users at HJH will require specific adjustment and extension of the current use of space at HJH.

  16. [Legal issues of physician-assisted euthanasia. Part III--Passive euthanasia, comparison of international legislation, conclusions for medical practice].

    Science.gov (United States)

    Laux, Johannes; Röbel, Andreas; Parzeller, Markus

    2013-01-01

    The generic term "passive euthanasia" includes different issues dealing with the omission, discontinuation or termination of life-sustaining or life-prolonging medical treatments. The debate around passive euthanasia focuses on the constitutional right of self-determination of every human being on the one hand and the constitutional mandate of the State to protect human life on the other. Issues of passive euthanasia always require a differentiated approach. Essentially, it comes down to the following: In Germany, the human right of self-determination includes the right to prohibit the performance of life-sustaining treatments, even if this leads to the death of the patient. A physician who does not take life-sustaining treatment measures because this is the free will expressed by the patient is not subject to prosecution. On the other hand, if the physician treats the patient against his will, this can be deemed a punishable act of bodily injury. The patient's will is decisive even if his concrete state of health does no longer allow him to freely express his will. In the Patient's Living Will Act of 2009, the German legislator clarified the juridical assessment of such constellations being of particular relevance in practice. A written living will of a person in which he requests to take or not to take certain medical treatment measures in case that he is no longer able to make the decision himself shall be binding for the people involved in the process of medical treatment. If there is no living will, the supposed will of the patient shall be relevant. In its judgment in the "Putz case", the German Federal Court of Justice ruled in 2010 that actions terminating a life-sustaining treatment that does not correspond to the patient's will must be limited to letting an already ongoing disease process run its course. In this context it is not important, however, whether treatment is discontinued by an active act or by omission. Under certain circumstances, the

  17. Short term administration of glucocorticoids in patients with protracted and chronic gout arthritis. Part III – frequency of adverse events

    Directory of Open Access Journals (Sweden)

    A A Fedorova

    2009-01-01

    Full Text Available Objective. To assess frequency of adverse events during short term administration of gluco- corticoid (GC in protracted and chronic gout arthritis. Material and methods. 59 pts with tophaceous gout (crystal-verified diagnosis and arthritis of three and more joints lasting more than a months in spite of treatment with sufficient doses of nonsteroidal anti-inflammatory drugs were included. Median age of pts was 56 [48;63], median disease duration – 15,2 years [7,4;20], median swollen joint count at the examination – 8 [5;11]. The patients were randomized into 2 groups. Methylprednisolone (MP 500 mg/day iv during 2 days and placebo im once was administered in one of them, betamethasone (BM 7 mg im once and placebo iv twice – in the other. Clinical evaluation of inflamed joints was performed every day. Standard laboratory examination and ECG were done before drug administration, at 3rd, 7th, and 14th day of follow up. Immunoreactive insulin level was evaluated before drug administration and at day 14. Blood pressure (BP was measured every day. Results. After first GC administration BP elevated in 28 (47% pts. In pts not having appropriate BP values BP elevated in 73% of cases. Pts with appropriate BP values showed less frequent BP elevation – 38% (p=0,02. In 8 (13% pts at day 3 after GC administration ECG signs of myocardial blood supply deterioration were revealed. Glucose level elevated in 10 (17% pts and after the second BM administration – in 5 (8% pts. Cholesterol level did not significantly change after 14 days of follow up but in 28 (47% pts it increased in comparison with baseline. Trigliceride level significantly decreased at day 14 from 149 [106; 187] to 108 [66,5; 172] mg/dl (p=0,02. 26 (44% pts had face hyperemia, 4 (7% –42 palpitation and 2 (3,4% – bitter taste. Conclusion. Administration of short course of GC in pts with gout requires monitoring of possible adverse events. Antihypertensive therapy providing appropriate BP

  18. An Assessment of the Quality of Life of Patients With Class III Deformities Treated With Orthognathic Surgery.

    Science.gov (United States)

    Kilinc, Adnan; Ertas, Umit

    2015-07-01

    To evaluate quality of life (QoL) from a broad perspective by a comparison of Turkish patients undergoing orthognathic surgery to correct Angle Class III skeletal deformity with a control group composed of participants without dentofacial deformity using general health, generic oral health, and condition-specific QoL approaches. Thirty patients who underwent orthognathic surgery to correct Class III relations (monomaxillary and bimaxillary groups) and 30 participants with Class I skeletal structure and good dentofacial harmony (control group) were evaluated. Condition-specific QoL through a 22-item Orthognathic Quality of Life Questionnaire (OQLQ), generic oral health-related QoL through a 14-item Short-Form Oral Health Impact Profile (OHIP-14), and generic health-related QoL through a 36-item Short-Form Health Survey (SF-36) were assessed. When the groups were compared, OQLQ scores showed a significant difference in the oral function domain only in the bimaxillary group (P orthognathic surgical patients appeared to be similar to that of participants without dentofacial deformities. Oral health-related QoL of orthognathic surgical patients seemed moderately similar to that of participants without dentofacial deformities. The combined use of these methods is helpful for evaluating QoL from a larger perspective. Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Breckinridge Project, initial effort. Report VII, Volume III. Cultural resource assessment socioeconomic background data

    Energy Technology Data Exchange (ETDEWEB)

    Macfarlane, Heather; Janzen, Donald E.

    1980-11-26

    This report has been prepared in conjunction with an environmental baseline study for a commercial coal conversion facility being conducted by Ashland Synthetic Fuels, Inc. (ASFI) and Airco Energy Company (AECO). This report represents a cultural resource assessment for the proposed plant site and two potential solid waste disposal areas. This assessment presents data collected by Dames and Moore during a recent archaeological reconnaissance of the unsurveyed southeastern portion of the proposed plant site and two potential solid waste disposal areas. Also, results of two previous surveys on the northern and southwestern portion of the plant site for American Smelting and Refining Company (ASARCO) and Kentucky Utilities are included. The Dames and Moore survey of the southeastern portion of the plant site identified one archaeological site, three standing structures and one historic cemetery. In addition 47 archaeological sites and six standing structures are known from two previous surveys of the remainder of the plant site (Cowan 1975 and Turnbow et al 1980). Eleven of the previously recorded archaeological sites were recommended for further assessment to evaluate their potential for inclusion within the Holt Bottoms Archaeological District currently listed on the National Register of Historic Places. None of the archaeological sites or standing structures located within the plant site during the Dames and Moore survey were recommended for further assessment. A total of eight archaeological sites were located during the Dames and Moore survey of the two potential solid waste disposal areas. Of this total only two sites were recommended for further assessment. Also, one previously unknown historic cemetry was located in the southernmost potential waste disposal area.

  20. Assessment of Long-Term Research Needs for Shale-Oil Recovery (FERWG-III)

    Energy Technology Data Exchange (ETDEWEB)

    Penner, S.S.

    1981-03-01

    The Fossil Energy Research Working Group (FERWG), at the request of E. Frieman (Director, Office of Energy Research) and G. Fumich, Jr. (Assistant Secretary for Fossil Fuels), has reviewed and evaluated the U.S. programs on shale-oil recovery. These studies were performed in order to provide an independent assessment of critical research areas that affect the long-term prospects for shale-oil availability. This report summarizes the findings and research recommendations of FERWG.

  1. Teaching and Assessing Racquet Games Using "Play Practice"--Part 2: Integrating Assessment into Teaching

    Science.gov (United States)

    van der Mars, Hans; Harvey, Stephen

    2010-01-01

    One of the central functions of teaching is formal assessment. However, formal assessment in school physical education often consists of attributing final grades to students at the conclusion of a unit (i.e., summative assessment). Moreover, grades have often been based on effort, attendance, and dress. Practical and authentic assessment…

  2. Assessment of quality of life in advanced, metastatic prostate cancer: an overview of randomized phase III trials.

    Science.gov (United States)

    Adamowicz, Krzysztof

    2017-04-01

    The chief therapeutic goal in metastatic prostate cancer is prolongation of survival with good quality of life . Quality of life (health-related) is often used as an endpoint parameter in phase III trials in metastatic prostate cancer, but the value of using HRQOL in this context has not been assessed to date. In order to evaluate the role of HRQOL assessment in contemporary phase III trials in prostate cancer, we searched the PubMed database to identify publications presenting the results of these trials on systemic therapies for prostate cancer published between January 2000 and December 2015. The analysis was separately presented in ten leading journals. We searched for companion papers reporting on QOL separately. We identified 84 studies which included a total of 57,193 patients in ten leading journals and 27 studies (7270 patients) in other journals. HRQOL parameters were described or mentioned in the main publication in 25 publications and four companions in total. There was no obvious trend in quality of life reported over two 8-year periods . The explicit statistical comparisons were reported in 22/25 cases (88 %), with significant difference in only 10/25 (40 %) studies and in eight cases (80 %) was conducive to the examined arm. There was no significant association between improvements in HRQOL and improvements in overall survival (OS) or any other primary endpoint in the analyzed studies. Only one study was found which presented the difference in quality of life with no difference in the primary endpoint. HRQOL is an indicator of benefit during treatment of patients with metastatic prostate cancer, but it is unlikely that HRQOL results can help clinicians choose between treatments given that they are not correlated with changes in OS or at other primary endpoints.

  3. Quality assessment in in vivo NMR spectroscopy: III. Clinical test objects: design, construction, and solutions

    DEFF Research Database (Denmark)

    Leach, M.O.; Collins, D.J.; Keevil, S

    1995-01-01

    Based on the requirements of test protocols developed to evaluate clinical MRS single slice and volume localisation sequences, two clinical test objects, STO1 and STO2 have been developed. The properties of a range of potential construction materials have been assessed, demonstrating that the water....../Perspex interface produced minimum susceptibility effects. The design of the objects has been evaluated in trials on different magnetic resonance instruments, with size and loading being adjusted to allow use on currently available equipment. Appropriate test solutions for 31P and 1H measurements have been...

  4. ASIST 2003: Part III: Posters.

    Science.gov (United States)

    Proceedings of the ASIST Annual Meeting, 2003

    2003-01-01

    Twenty-three posters address topics including access to information; metadata; personal information management; scholarly information communication; online resources; content analysis; interfaces; Web queries; information evaluation; informatics; information needs; search effectiveness; digital libraries; diversity; automated indexing; e-commerce;…

  5. MicroVent (part III)

    DEFF Research Database (Denmark)

    Dreau, Jerome Le; Heiselberg, Per Kvols; Jensen, Rasmus Lund

    This study aims at using the InVentilate unit in the cooling case, without heat recovery. It results in a relatively low inlet air temperature. Different solutions have been tested to decrease the risk of draught in the occupied zone: ‐ Using a mixer (2 designs) ‐ Using an inlet grille ‐ Using...

  6. Designing screened enclosures: Part III.

    Science.gov (United States)

    Bearpark, Jon

    2006-04-01

    The engineer will be able to design a successful screened enclosure using careful selection of materials, gaskets and, if necessary, screened optical windows. Many of the techniques covered in this series of articles can be employed during the research and development stage to arrive at a cost-effective solution that offers the required mechanical, aesthetical, environmental and electrical properties.

  7. EPHECT III: Health risk assessment of exposure to household consumer products.

    Science.gov (United States)

    Trantallidi, M; Dimitroulopoulou, C; Wolkoff, P; Kephalopoulos, S; Carrer, P

    2015-12-01

    In the framework of the EU EPHECT project (Emissions, Exposure Patterns and Health Effects of Consumer Products in the EU), irritative and respiratory effects were assessed in relation to acute (30-min) and long-term (24-h) inhalation exposure to key and emerging indoor air pollutants emitted during household use of selected consumer products. A detailed Health Risk Assessment (HRA) was performed for five selected pollutants of respiratory health relevance, namely acrolein, formaldehyde, naphthalene, d-limonene and α-pinene. For each pollutant, the Critical Exposure Limit (CEL) was compared to indoor air concentrations and exposure estimates for the use of 15 selected consumer products by two population groups (housekeepers and retired people) in the four geographical regions of Europe (North, West, South, East), which were derived previously based on microenvironmental modelling. For the present HRA, health-based CELs were derived for certain compounds in case indoor air quality guidelines were not available by the World Health Organization for end-points relevant to the current study. For each pollutant, the highest indoor air concentrations in each microenvironment and exposure estimates across home microenvironments during the day were lower than the corresponding acute and long-term CELs. However, considerable contributions, especially to acute exposures, were obtained in some cases, such as formaldehyde emissions resulting from single product use of a floor cleaning agent (82% CEL), a candle (10% CEL) and an electric air freshener (17% CEL). Regarding multiple product use, the case of 30-min formaldehyde exposure reaching 34% CEL when eight product classes were used across home microenvironments, i.e. all-purpose/kitchen/floor cleaning agents, furniture/floor polish, combustible/electric air fresheners, and perfume, needs to be highlighted. Such estimated values should be evaluated with caution, as these may be attributed to the exposure scenarios

  8. Priority assessment of toxic substances in life cycle assessment. III: Export of potential impact over time and space.

    Science.gov (United States)

    Huijbregts, M A; Guinée, J B; Reijnders, L

    2001-07-01

    Toxicity potentials are scaling factors used in life cycle assessment (LCA) indicating their relative importance in terms of potential toxic impacts. This paper presents the results of an uncertainty assessment of toxicity potentials for 181 substances that were calculated with the global nested multi-media fate, exposure and effects model USES-LCA. The variance in toxicity potentials resulting from choices in the modelling procedure was quantified by means of scenario analysis. A first scenario analysis showed to what extent potential impacts in the relatively short term are obscured by the inclusion of impacts on the very long term. Toxicity potentials representing potential impacts over time horizons of 20, 100 and 500 years were compared with toxicity potentials representing potential impacts over an infinite time horizon. Time horizon dependent differences up to 6.5 orders of magnitude were found for metal toxicity potentials, while for toxicity potentials of organic substances under study, differences remain within 0.5 orders of magnitude. The second scenario analysis addressed to what extent potential impacts on the continental scale are obscured by the inclusion of impacts on the global scale. Exclusion of potential impacts on the global scale changed the toxicity potentials of metals and volatile persistent halogenated organics up to 2.3 orders of magnitude. These scenario analyses also provide the basis for determining exports to future generations and outside the emission area.

  9. Translation and validation of the Danish version of the brief family assessment measure III in a sample of acutely admitted elderly medical patients

    DEFF Research Database (Denmark)

    Shamali, Mahdi; Konradsen, Hanne; Lauridsen, Jørgen T

    2018-01-01

    that measures family functioning. However, no Danish translation or measure of its psychometric properties in a Danish population is available. The purpose of this study was to translate the Brief FAM-III into Danish and then evaluate its psychometric properties in elderly patients. METHODS: The Brief FAM......RATIONALE AND OBJECTIVE: Family functioning plays a pivotal role in the adaptation to illness of both individuals and families, especially among elderly patients. The Brief Family Assessment Measure Third Edition (Brief FAM-III) is among the most frequently used self-report instruments...... analysis was used to examine the construct validity of the Brief FAM-III. RESULTS: Evaluation of the Danish version of the Brief FAM-III confirmed the three-factor structure (General Scale, Self-Rating Scale and Dyadic Relationships Scale) identified in the original instrument. However, goodness...

  10. Uptake of iron (III)-ethylenediamine-N, N, N', N'-tetraacetic acid complex by phosphatidylcholine lipid film. Part II. Effect of film curvature.

    Science.gov (United States)

    Villeneuve, Masumi; Tanaka, Mihoko; Saito, Natsumi; Sakamoto, Hiroyasu; Hayami, Yoshiteru

    2018-01-01

    Mixed micelles formed in a ternary-solute aqueous solution of NaOH, iron (III)-ethylenediamine-N, N, N', N'-tetraacetic acid complex (Fe-EDTA) and 1,2-diheptanoyl-sn-glycero-3-phosphatidyl choline (DHPC) were studied and compared with the mixed adsorbed film reported in Part I of this series to clarify the effect of the curvature of molecular assemblies on the interactions between their Fe-EDTA and DHPC constituents. The critical micelle concentrations (CMCs), surface tension at the CMC, and solution pH were measured as functions of the mole fractions of NaOH and DHPC. Rigorous thermodynamic equations were derived, in which the overall proton dissociation equilibria of Fe-EDTA and DHPC were taken into consideration, and applied to experimental data to obtain phase diagrams of micelle formation and the micelle-adsorbed film equilibrium. It was found that when the bulk solution was strongly acidic, Fe-EDTA was incorporated in the micelles. However, the adsorbed film was more Fe-EDTA-enriched than the micelle. These findings imply that a flat cell membrane is more permeable to an iron complex than a cell membrane with positive curvature. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Effects of environmental factors on larval development of marine invertebrates: Annual progress report. Part III. Regeneration as an indicator of environmental stress

    Energy Technology Data Exchange (ETDEWEB)

    Costlow, J.D.

    1988-08-26

    Megalopae of the mud crab, Rithropanopeus harriii, within the control series were maintained with both chelae intact, as well as with one chela autotomized, in 20 parts per thousand seawater and in the ''acetone control.'' Percent survival to crab III for larvae of the control series, and larvae maintained in four concentrations of the herbicide, Alachlor is presented. As the concentration of Alachlor increases, the percent survival decreases. A comparison of these same levels of concentration of Alachlor as they relate to the time of ecdysis is shown. There is no statistically significant impact on molting. The interval between crab I and crab II was also unaffected by the levels of Alachlor used. Normal regeneration of the autotomized claw of the megalopa in the control series occurred in 100% of the larvae. As the larvae were exposed to Alachlor of different concentrtions, the percent normal regenertion decreased and the percent abnormal regeneration increased. The process of regeneration can be used as an extremely sensitive indicator of sublethal levels for a varity of contaminants. A second aspect of the research as originally planned was to determine the effect of carbamates on regeneration of chelae in megalopa and early juveniles of the mud crab Rhithropanopeus harrisii.

  12. Design of a Phase III cluster randomized trial to assess the efficacy and safety of a malaria transmission blocking vaccine.

    Science.gov (United States)

    Delrieu, Isabelle; Leboulleux, Didier; Ivinson, Karen; Gessner, Bradford D

    2015-03-24

    Vaccines interrupting Plasmodium falciparum malaria transmission targeting sexual, sporogonic, or mosquito-stage antigens (SSM-VIMT) are currently under development to reduce malaria transmission. An international group of malaria experts was established to evaluate the feasibility and optimal design of a Phase III cluster randomized trial (CRT) that could support regulatory review and approval of an SSM-VIMT. The consensus design is a CRT with a sentinel population randomly selected from defined inner and buffer zones in each cluster, a cluster size sufficient to assess true vaccine efficacy in the inner zone, and inclusion of ongoing assessment of vaccine impact stratified by distance of residence from the cluster edge. Trials should be conducted first in areas of moderate transmission, where SSM-VIMT impact should be greatest. Sample size estimates suggest that such a trial is feasible, and within the range of previously supported trials of malaria interventions, although substantial issues to implementation exist. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Reflecting Equity and Diversity. Part I: Guidelines and Procedure for Evaluating Bias in Instructional Materials. Part II: Bias Awareness Training Worksheets. Part III: Bias Awareness and Procedure Training Course.

    Science.gov (United States)

    Bebermeyer, Jim; Edmond, Mary, Ed.

    Reflecting a need to prepare students for working in diverse organizations, this document was developed to increase school officials' awareness of bias in instructional materials and help them select bias-free materials. A number of the examples illustrate situations dealing with diversity in the workplace. The guide is divided into three parts:…

  14. Toxicological assessment of kretek cigarettes: Part 1: background, assessment approach, and summary of findings.

    Science.gov (United States)

    Roemer, E; Dempsey, R; Schorp, M K

    2014-12-01

    This publication introduces a series of six other publications describing the toxicological assessment of kretek cigarettes, i.e., cigarettes characterized primarily by the use of a significant amount of cloves as an ingredient added to the tobacco. This paper presents background information on kretek cigarettes, describes the general approach of the in vitro and in vivo toxicological assessment of mainstream smoke from kretek cigarettes, presents the methodology used, and summarizes the results of the assessment program. In summary, the smoke from kretek cigarettes gives rise to the typical cigarette smoke-related effects known from American-blended cigarettes, does not reveal any novel toxicity, and exhibits an unexpected distinct attenuation of pulmonary inflammation. Based on equal amounts of smoke total particulate matter (TPM), kretek cigarettes deliver less toxicants when compared to American-blended cigarettes; when assessed in vitro, the smoke from kretek cigarettes is less cytotoxic (gas/vapor phase) and less mutagenic (TPM). When assessed in vivo, kretek cigarette smoke shows lower toxicity in the respiratory tract. When based on an equal nicotine basis, several of the toxicity endpoints in kretek cigarettes become equivalent to American-blended cigarettes. The data do not indicate an increased hazard potential of kreteks compared to American-blended cigarettes. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Presentation of safety after closure of the repository for spent nuclear fuel. Main report of the project SR-Site. Part III; Redovisning av saekerhet efter foerslutning av slutfoervaret foer anvaent kaernbraensle. Huvudrapport fraan projekt SR-Site. Del III

    Energy Technology Data Exchange (ETDEWEB)

    2011-07-01

    The purpose of the safety assessment SR-Site is to investigate whether a safe repository for spent nuclear fuel by KBS-3 type can be constructed at Forsmark in Oesthammar in Sweden. The location of the Forsmark has been selected based on results of several surveys from surface conditions at depth in Forsmark and in Laxemar in Oskarshamn. The choice of location is not justified in SR-Site Report, but in other attachments to SKB's permit applications. SR-Site Report is an important part of SKB's permit applications to construct and operate a repository for spent nuclear fuel at Forsmark in Oesthammar. The purpose of the report in the applications is to show that a repository at Forsmark is safe after closure

  16. Regional risk assessment for contaminated sites part 1: vulnerability assessment by multicriteria decision analysis.

    Science.gov (United States)

    Zabeo, A; Pizzol, L; Agostini, P; Critto, A; Giove, S; Marcomini, A

    2011-11-01

    As highlighted in the EU Soil Communication, local contamination is one of the main soil threats and it is often related to present and past industrial activities which left a legacy of a high number of contaminated sites in Europe. These contaminated sites can be harmful to many different receptors according to their sensitivity/susceptibility to contamination, and specific vulnerability evaluations are needed in order to manage this widely spread environmental issue. In this paper a novel comprehensive vulnerability assessment framework to assess regional receptor susceptibility to contaminated site is presented. The developed methodology, which combines multi criteria decision analysis (MCDA) techniques and spatial analysis, can be applied to different receptors recognized as relevant for regional assessment. In order to characterize each receptor, picked parameters significant for the estimation of the vulnerability to contaminated sites have been selected, normalized and aggregated by means of multi criteria decision analysis (MCDA) techniques. The developed MCDA methodology, based on the Choquet integral, allows to include expert judgments for the elicitation of synergic and conflicting effects between involved criteria and is applied to all the geographical objects representing the identified receptors. To test the potential of the vulnerability methodology, it has been applied to a specific case study area in the upper Silesia region of Poland where it proved to be reliable and consistent with the environmental experts' expected results. The vulnerability assessment results indicate that groundwater is the most vulnerable receptor characterized by a wide area with vulnerability scores belonging to the highest vulnerability class. As far as the other receptors are concerned, human health and surface water are characterized by quite homogeneous vulnerability scores falling in the medium-high vulnerability classes, while protected areas resulted to be the less

  17. Proprioception in musculoskeletal rehabilitation. Part 1: Basic science and principles of assessment and clinical interventions.

    Science.gov (United States)

    Röijezon, Ulrik; Clark, Nicholas C; Treleaven, Julia

    2015-06-01

    Impaired proprioception has been reported as a feature in a number of musculoskeletal disorders of various body parts, from the cervical spine to the ankle. Proprioception deficits can occur as a result of traumatic damage, e.g., to ligaments and muscles, but can also occur in association with painful disorders of a gradual-onset nature. Muscle fatigue can also adversely affect proprioception and this has implications for both symptomatic and asymptomatic individuals. Due to the importance of proprioception for sensorimotor control, specific methods for assessment and training of proprioception have been developed for both the spine and the extremities. The aim of this first part of a two part series on proprioception in musculoskeletal rehabilitation is to present a theory based overview of the role of proprioception in sensorimotor control, assessment, causes and findings of altered proprioception in musculoskeletal disorders and general principles of interventions targeting proprioception. An understanding of the basic science of proprioception, consequences of disturbances and theories behind assessment and interventions is vital for the clinical management of musculoskeletal disorders. Part one of this series supplies a theoretical base for part two which is more practically and clinically orientated, covering specific examples of methods for clinical assessment and interventions to improve proprioception in the spine and the extremities. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Oral health assessment and mouth care for children and young people receiving palliative care. Part one.

    Science.gov (United States)

    Sargeant, Stephanie; Chamley, Carol

    2013-03-01

    This is the first part of two articles exploring oral health problems and treatments for children receiving palliative care, successful management of which can improve considerably the quality of life for this group of children and young people. Part one includes an adapted oral health assessment tool for use in children and young people with complex and palliative healthcare needs that has the potential to help nurses identify and monitor oral health problems and prevent or minimise oral problems from developing. Part two--to be published next month--focuses on basic oral hygiene and the management of specific oral health problems.

  19. Regional risk assessment as a part of the long-term receiving water study.

    Science.gov (United States)

    Landis, Wayne G; Thomas, Jill F

    2009-04-01

    A regional-scale watershed assessment using the relative risk model has now been performed on each of the watersheds that are part of the Long-Term Receiving Waters Study (LTRWS) to generate patterns of risk at each study site. The watersheds assessed included the lower McKenzie and mid-Willamette rivers in Oregon, USA; Codorus Creek in Pennsylvania, USA; and the Leaf River in Mississippi, USA. In each case, the goal was to put the LTRWS into a watershed and regional context, including multiple sources, stressors, habitats, and assessment endpoints. In each instance, the relative risk model provided measures of relative risk and testable hypotheses about patterns within the watersheds. There were similarities among the 3 risk studies. First, land use within the watershed was the most important driver of risk in each instance, even compared with point sources. Second, the list of endpoints was similar for each risk assessment. Water quality was held as important, along with populations critical to recreation or commercial use. At each site, data from the LTRWS and other sources could be used to support the risk patterns predicted from the risk assessment process. However, the sampling design of the LTRWS prevented the confirmation of specific cause-effect relationships. A fundamental conclusion is that risk assessment, using an adaptation of the relative risk model, should be performed as an integral part of any watershed assessment and management effort. These initial watershed risk assessments have led to similar assessments across the world.

  20. Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ratio: a quantitative assessment

    NARCIS (Netherlands)

    Marijianowski, M. M.; Teeling, P.; Mann, J.; Becker, A. E.

    1995-01-01

    The aim of this study was to quantify total collagen and the type I/type III collagen ratio and their localization in hearts with dilated cardiomyopathy. Patients with dilated cardiomyopathy have an increase in intramyocardial fibrillar collagen. Types I and III are the main constituents and have

  1. Analysis of Item-Level Bias in the Bayley-III Language Subscales: The Validity and Utility of Standardized Language Assessment in a Multilingual Setting

    Science.gov (United States)

    Goh, Shaun K. Y.; Tham, Elaine K. H.; Magiati, Iliana; Sim, Litwee; Sanmugam, Shamini; Qiu, Anqi; Daniel, Mary L.; Broekman, Birit F. P.; Rifkin-Graboi, Anne

    2017-01-01

    Purpose: The purpose of this study was to improve standardized language assessments among bilingual toddlers by investigating and removing the effects of bias due to unfamiliarity with cultural norms or a distributed language system. Method: The Expressive and Receptive Bayley-III language scales were adapted for use in a multilingual country…

  2. An integrated model for the assessment of global water resources – Part 2: Applications and assessments

    Directory of Open Access Journals (Sweden)

    N. Hanasaki

    2008-07-01

    Full Text Available To assess global water resources from the perspective of subannual variation in water availability and water use, an integrated water resources model was developed. In a companion report, we presented the global meteorological forcing input used to drive the model and six modules, namely, the land surface hydrology module, the river routing module, the crop growth module, the reservoir operation module, the environmental flow requirement module, and the anthropogenic withdrawal module. Here, we present the results of the model application and global water resources assessments. First, the timing and volume of simulated agriculture water use were examined because agricultural use composes approximately 85% of total consumptive water withdrawal in the world. The estimated crop calendar showed good agreement with earlier reports for wheat, maize, and rice in major countries of production. In major countries, the error in the planting date was ±1 mo, but there were some exceptional cases. The estimated irrigation water withdrawal also showed fair agreement with country statistics, but tended to be underestimated in countries in the Asian monsoon region. The results indicate the validity of the model and the input meteorological forcing because site-specific parameter tuning was not used in the series of simulations. Finally, global water resources were assessed on a subannual basis using a newly devised index. This index located water-stressed regions that were undetected in earlier studies. These regions, which are indicated by a gap in the subannual distribution of water availability and water use, include the Sahel, the Asian monsoon region, and southern Africa. The simulation results show that the reservoir operations of major reservoirs (>1 km3 and the allocation of environmental flow requirements can alter the population under high water stress by approximately −11% to +5% globally. The integrated model is applicable to

  3. Indoor Air Quality Assessment Based on Human Physiology - Part 3. Applications

    Directory of Open Access Journals (Sweden)

    M. V. Jokl

    2003-01-01

    Full Text Available The proposed evaluation system allows something quite new: a the assessment of the effect of each environmental component (constituent on the total environment level, b accurate estimation of air volume for various locations, human occupations and sources of harmful gases. Additional benefits are listed at the conclusion of this part.

  4. Porosity testing methods for the quality assessment of selective laser melted parts

    NARCIS (Netherlands)

    Wits, Wessel W.; Carmignato, Simone; Zanini, Filippo; Vaneker, Thomas H.J.

    2016-01-01

    This study focuses on the comparison of porosity testing methods for the quality assessment of selective laser melted parts. Porosity is regarded as important quality indicator in metal additive manufacturing. Various destructive and non-destructive testing methods are compared, ranging from global

  5. IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials)

    Science.gov (United States)

    In August 2014, EPA released the second part of draft literature searches and associated search strategies, evidence tables, and exposure response arrays for Cr(VI) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA w...

  6. MATLAB-based Applications for Image Processing and Image Quality AssessmentPart II: Experimental Results

    Directory of Open Access Journals (Sweden)

    L. Krasula

    2012-04-01

    Full Text Available The paper provides an overview of some possible usage of the software described in the Part I. It contains the real examples of image quality improvement, distortion simulations, objective and subjective quality assessment and other ways of image processing that can be obtained by the individual applications.

  7. 49 CFR Appendix B to Part 209 - Federal Railroad Administration Guidelines for Initial Hazardous Materials Assessments

    Science.gov (United States)

    2010-10-01

    ... were International Maritime Dangerous Goods (IMDG) labels instead of 10″ placards. (Unit of violation... 49 Transportation 4 2010-10-01 2010-10-01 false Federal Railroad Administration Guidelines for Initial Hazardous Materials Assessments B Appendix B to Part 209 Transportation Other Regulations Relating...

  8. Mycological Assessment of Suya Sold in Some Parts of Minna, Niger ...

    African Journals Online (AJOL)

    Mycological assessments of Suya sold in some part of Minna were conducted. A total of 20 samples were collected from 10 randomly selected suya spots from ten (10) locations in Minna namely- Tunga, Ungwan Daji , Dutsen Kuran Hausa, Chanchaga, Bosso, Maikunkele, Maitumbi, Kwangila, Barikin Sale and Sayeko.

  9. Mycological Assessment of Suya Sold in Some Parts of Minna, Niger ...

    African Journals Online (AJOL)

    Admin

    Abstract. Mycological assessments of Suya sold in some part of Minna were conducted. A total of 20 samples were collected from 10 randomly selected suya spots from ten (10) locations in. Minna namely- Tunga, Ungwan Daji , Dutsen Kuran Hausa, Chanchaga, Bosso, Maikunkele,. Maitumbi, Kwangila, Barikin Sale and ...

  10. Tavaborole in Difficult-to-Treat Onychomycosis Cases: A Post-hoc Assessment of Phase III Subjects.

    Science.gov (United States)

    Aly, Raza; Gupta, Aditya K; Winter, Tate; Zane, Lee T; Vlahovic, Tracey

    2017-10-01

    Toenail onychomycosis is a chronic fungal infection that often requires prolonged treatment in order to effectively manage pathogenic organisms and obtain a clear nail. Traditionally, certain clinical features of onychomycosis, including the presence of substantial lateral disease, focal fungal masses, yellow/brown streaks, and extensive nail involvement (ie, >50%), indicate a poor treatment prognosis and have proven difficult-to-treat with oral or traditional topical therapies. Owing to the novel features of topical tavaborole, we sought to understand the potential utility of tavaborole in difficult-to-treat onychomycosis. A blinded, post-hoc assessment of Phase III trials was conducted, focusing on initial presentation, midpoint assessment (24 weeks), and final outcomes (52 weeks) in subjects identified as having difficult-to-treat onychomycosis and treated for 48 weeks with once-daily application of either tavaborole 5% solution or vehicle. Our post-hoc analysis identified 84 difficult-to-treat cases (tavaborole 5%; n=60; vehicle, n=24) in subjects with toenail onychomycosis due to Trichophyton rubrum or Trichophyton mentagrophytes. No subjects identified as difficult-to-treat and treated with vehicle achieved a complete cure, while 6 subjects treated with tavaborole 5% attained a completely clear nail and negative mycology. Similarly, 7 subjects treated with tavaborole 5% solution achieved an almost complete cure (≤10% involvement and negative mycology) while 1 subject on vehicle achieved an almost complete cure. We present a case series of 4 patients, of varying age and difficult-to-treat clinical features, which responded positively to tavaborole 5% solution. Three of the subjects achieved complete cure after being treated with tavaborole 5%, with one additional subject (an 88-year-old female) achieving an almost complete clear nail by treatment end. The outcomes presented here may not be reflective of patients that may present with these clinical

  11. Assessment Of Various Activities Indicators Made Available To Farmers For Participation Through Fadama Iii Agricultural Project Delivery Agency In Bayelsa State Nigeria

    Directory of Open Access Journals (Sweden)

    Ominikari

    2017-09-01

    Full Text Available The study assessed the activities made available to farmers for participation through Fadama III Project in Bayelsa State. Objective of the study was activities made available to farmers through National Fadama III Agricultural project delivery agency. Purposive sampling technique was used to select One-Hundred and fifty 150 farmers that participated and 150 staff from the delivery agency. Data were collected with a structured questionnaire. The data collected was analyzed using frequency count percentage mean X amp773 standard deviation STD while z-test was used to test the null hypotheses at 0.05 level of significance. Farmers in the state truly believe in the existence of various activities in Fadama III project in the state as being made available to them through the delivery agency. The result of the z-test showed that the mean response of the farmers in Fadama III projects was 2.986 while the mean response of the delivery agency was 3.793 there was significant difference z -20.245 in the mean score response of the delivery agency and participants of National Fadama III Agricultural Project on the various activities that were made available to the farmers at P amp8804 0.05. The study therefore recommended that National Fadama III Project activities should be reorganized to be of great benefit to the farmers proper training in all the activities should be made available for effective participation empower the participants to improve their income level and to move them away from poverty by improving their standard of living by reorganizing the Fadama III Project.

  12. Confirmatory factor analysis of an integrated model of psycopathology assessed with MMPI-2-RF and the MCMI-III

    OpenAIRE

    Ruiz Rodríguez, José; Fusté Escolano, Adela; Ferrando, P.J.; García Grau, Eugeni

    2013-01-01

    We presented an integrated hierarchical model of psychopathology that more accurately captures empirical patterns of comorbidity between clinical syndromes and personality disorders. In order to verify the structural validity of the model proposed, this study aimed to analyze the convergence between the Restructured Clinical (RC) scales and Personality scales (PSY-5) of the MMPI-2-RF and the Clinical Syndrome and Personality Disorder scales of the MCMI-III. The MMPI-2-RF and MCMI-III we...

  13. A consistent and conservative scheme for incompressible MHD flows at a low magnetic Reynolds number. Part III: On a staggered mesh

    Science.gov (United States)

    Ni, Ming-Jiu; Li, Jun-Feng

    2012-01-01

    The consistent and conservative scheme developed on a rectangular collocated mesh [M.-J. Ni, R. Munipalli, N.B. Morley, P. Huang, M.A. Abdou, A current density conservative scheme for incompressible MHD flows at a low magnetic Reynolds number. Part I: on a rectangular collocated grid system, Journal of Computational Physics 227 (2007) 174-204] and on an arbitrary collocated mesh [M.-J. Ni, R. Munipalli, P. Huang, N.B. Morley, M.A. Abdou, A current density conservative scheme for incompressible MHD flows at a low magnetic Reynolds number. Part II: on an arbitrary collocated mesh, Journal of Computational Physics 227 (2007) 205-228] has been extended and specially designed for calculation of the Lorentz force on a staggered grid system (Part III) by solving the electrical potential equation for magnetohydrodynamics (MHD) at a low magnetic Reynolds number. In a staggered mesh, pressure ( p) and electrical potential ( φ) are located in the cell center, while velocities and current fluxes are located on the cell faces of a main control volume. The scheme numerically meets the physical conservation laws, charge conservation law and momentum conservation law. Physically, the Lorentz force conserves the momentum when the magnetic field is constant or spatial coordinate independent. The calculation of current density fluxes on cell faces is conducted using a scheme consistent with the discretization for solution of the electrical potential Poisson equation, which can ensure the calculated current density conserves the charge. A divergence formula of the Lorentz force is used to calculate the Lorentz force at the cell center of a main control volume, which can numerically conserve the momentum at constant or spatial coordinate independent magnetic field. The calculated cell-center Lorentz forces are then interpolated to the cell faces, which are used to obtain the corresponding velocity fluxes by solving the momentum equations. The "conservative" is an important property of

  14. Portable Diagnostics Technology Assessment for Space Missions. Part 2; Market Survey

    Science.gov (United States)

    Nelson, Emily S.; Chait, Arnon

    2010-01-01

    A mission to Mars of several years duration requires more demanding standards for all onboard instruments than a 6-month mission to the Moon or the International Space Station. In Part 1, we evaluated generic technologies and suitability to NASA needs. This prior work considered crew safety, device maturity and flightworthiness, resource consumption, and medical value. In Part 2, we continue the study by assessing the current marketplace for reliable Point-of-Care diagnostics. The ultimate goal of this project is to provide a set of objective analytical tools to suggest efficient strategies for reaching specific medical targets for any given space mission as program needs, technological development, and scientific understanding evolve.

  15. Pain management: screening and assessment of pain as part of a comprehensive case management process.

    Science.gov (United States)

    Carter, Jolynne Jo; Watson, Annette C; Sminkey, Patrice V

    2014-01-01

    Pain management, episodic and chronic, is a major issue in health care today, affecting more than 76 million people across care-delivery settings from acute care to rehabilitation, workers' compensation to primary care. As a result, professional case managers occupy an important role within an interdisciplinary care team to address pain as part of a comprehensive case management process, from intake and assessment through care delivery and transitions of care. Pain management, as part of the comprehensive case management process, is applicable across the case management spectrum, including hospitals, accountable care organizations, patient-centered medical homes, physician practices, clinics, occupational health clinics, workers' compensation, and other settings in which case managers work with clients and their support systems. The prevalence of pain across the care continuum, affecting individuals at various stages of an individual's lifecycle, raises the importance of acute and chronic pain assessments as part of the overall case assessment. In addition to screening for pain, case management assessments must look for signs of depression, as well as the potential for abuse/misuse of opioid medications, which is an alarming public health threat. Given their clinical expertise, their roles as advocates, their ability to conduct a comprehensive client/patient assessment, and their expertise in using tools such as motivational interviewing, professional case managers-and particularly those who are board certified-occupy a central role in pain management as part of a patient-centered approach. Case managers must understand the impact of both pain and pain medications on the client's daily functions, from a health and safety perspective. Pain management should be examined through the lens of professional case management, and what a competent case manager can do to advocate for clients who are experiencing pain, whether acute or chronic, while facilitating the sharing

  16. Neurodevelopmental outcome of Italian preterm children at 1year of corrected age by Bayley-III scales: An assessment using local norms.

    Science.gov (United States)

    Gasparini, Corinna; Caravale, Barbara; Rea, Monica; Coletti, Maria Franca; Tonchei, Valentina; Bucci, Silvia; Dotta, Andrea; De Curtis, Mario; Gentile, Simonetta; Ferri, Rosa

    2017-10-01

    Premature birth is often associated with neurodevelopmental difficulties throughout childhood. In the first three years of life, the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III) constitute one of the most used tools for assessing child development. Since Bayley-III original norms are based on United States (US) population, it remains uncertain whether their use in other countries (e.g., European) is appropriate. This research aimed to examine neurodevelopment of preterm infants and full-term infants, using Bayley-III US norms in comparison to Italian (IT) norms. Patterns of developmental outcomes for both infant groups were also explored. 104 preterm and 58 full-term infants were included in the study. Bayley-III was used for neurodevelopmental assessment at 1year of corrected age, considering both IT and US norms for scores computation. Comparing scores obtained with IT vs US norms, differences in means were all significant across five subscales (pdevelopment compared to IT norms. These findings emphasize the need to early detect children at risk for developmental delay and to plan early intervention. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Q-SEA – a tool for quality assessment of ethics analyses conducted as part of health technology assessments

    Directory of Open Access Journals (Sweden)

    Scott, Anna Mae

    2017-03-01

    Full Text Available Introduction: Assessment of ethics issues is an important part of health technology assessments (HTA. However, in terms of existence of quality assessment tools, ethics for HTA is methodologically underdeveloped in comparison to other areas of HTA, such as clinical or cost effectiveness. Objective: To methodologically advance ethics for HTA by: (1 proposing and elaborating Q-SEA, the first instrument for quality assessment of ethics analyses, and (2 applying Q-SEA to a sample systematic review of ethics for HTA, in order to illustrate and facilitate its use.Methods: To develop a list of items for the Q-SEA instrument, we systematically reviewed the literature on methodology in ethics for HTA, reviewed HTA organizations’ websites, and solicited views from 32 experts in the field of ethics for HTA at two 2-day workshops. We subsequently refined Q-SEA through its application to an ethics analysis conducted for HTA. Results: Q-SEA instrument consists of two domains – the process domain and the output domain. The process domain consists of 5 elements: research question, literature search, inclusion/exclusion criteria, perspective, and ethics framework. The output domain consists of completeness, bias, implications, conceptual clarification, and conflicting values. Conclusion: Q-SEA is the first instrument for quality assessment of ethics analyses in HTA. Further refinements to the instrument to enhance its usability continue.

  18. Q-SEA – a tool for quality assessment of ethics analyses conducted as part of health technology assessments

    Science.gov (United States)

    Scott, Anna Mae; Hofmann, Björn; Gutiérrez-Ibarluzea, Iñaki; Bakke Lysdahl, Kristin; Sandman, Lars; Bombard, Yvonne

    2017-01-01

    Introduction: Assessment of ethics issues is an important part of health technology assessments (HTA). However, in terms of existence of quality assessment tools, ethics for HTA is methodologically underdeveloped in comparison to other areas of HTA, such as clinical or cost effectiveness. Objective: To methodologically advance ethics for HTA by: (1) proposing and elaborating Q-SEA, the first instrument for quality assessment of ethics analyses, and (2) applying Q-SEA to a sample systematic review of ethics for HTA, in order to illustrate and facilitate its use. Methods: To develop a list of items for the Q-SEA instrument, we systematically reviewed the literature on methodology in ethics for HTA, reviewed HTA organizations’ websites, and solicited views from 32 experts in the field of ethics for HTA at two 2-day workshops. We subsequently refined Q-SEA through its application to an ethics analysis conducted for HTA. Results: Q-SEA instrument consists of two domains – the process domain and the output domain. The process domain consists of 5 elements: research question, literature search, inclusion/exclusion criteria, perspective, and ethics framework. The output domain consists of 5 elements: completeness, bias, implications, conceptual clarification, and conflicting values. Conclusion: Q-SEA is the first instrument for quality assessment of ethics analyses in HTA. Further refinements to the instrument to enhance its usability continue. PMID:28326147

  19. Proceedings of the Mongolian Biodiversity Databank Workshop: Assessing the Conservation Status of Mongolian Mammals and Fishes: III – Fishes: Assessment Results and Threats

    Directory of Open Access Journals (Sweden)

    Joanne F. Ocock

    2005-12-01

    Full Text Available The Mongolian Biodiversity Databank Workshop was held at the National University of Mongolia and Hustai National Park from 1 st October to 4 th November, 2005. As part of the workshop, a working group of fish experts assessed the conservation status of all Mongolian fishes using the IUCN Catego - ries and Criteria. Of the 64 fish species found in Mongolia, 48 were assessed, with 16 considered Not Applicable (NA by the working group. Only one species, the Siberian sturgeon ( Acipenser baerii was assessed as Critically Endangered (CR in Mongolia, however six species were assigned Endangered (EN status. Four were found to be Vulnerable (VU and three were assessed to be Near Threatened (NT. Forty-eight percent of Mongolian fishes were Data Deficient (DD and 25% were Least Concern (LC. The north-east of Mongolia was most species rich, particularly the Onon River basin and Buir Lake. There was no trend for where the most threatened species occurred as they were found throughout the north of Mongolia. Hunting/fishing was the greatest threat to Mongolian fishes, followed by resource extraction and pollution.

  20. Further Characterization of a Type III Secretion System (T3SS) and of a New Effector Protein from a Clinical Isolate of Aeromonas Hydrophila - Part I

    Science.gov (United States)

    A type III secretion system (T3SS)-associated cytotoxin, AexT, with ADP-ribosyltransferase activity and homology to Pseudomonas aeruginosa bifuncational toxins ExoT/S, was recently identified from a fish pathogen Aeromonas salmonicida. In this study, we reported the molecular cha...

  1. Assessment of land degradation hazards, Jamui district India using IRS P6 LISS-III multi-temporal satellite data

    Science.gov (United States)

    Londhe, S.; Talukdar, G.; Deshmukh, B.; Srivastava, S.

    2009-04-01

    Asian region is under high pressure to supply required food for rapidly increasing population. This, together with harsh climatic conditions and changes in land use accelerates land degradation process, which eventually leads to yield reduction. Soil erosion is one of the mode of land degradation and serious problem in granitic terrains of Semi-arid regions. This accounts the loss of fertile soil through detachment and transportation from one place and deposition to another place resulting in decreased soil fertility and reduced crop yields as well as sedimentation of rivers and reservoirs. IRSP6 LISS-III satellite data of three different season viz. Khrif, rabi and summer data in conjunction of with Survey of India toposheets and subsequent ground truth has been used for assessment of land degradation using onscreen visual interpretation. Based on severity of degradation the area is mapped into sheet erosion, rill erosion, gully erosion, ravenous erosion, seasonal waterlogging and rock out crops. The complex degradation problems having more than one degradation processes were appropriately represented in the mapping unit as combination. In order to understand the associated land use and feasibility of reclamination of degraded lands different landforms are identified along with land use level 1 classification. It was observed that 23.2 % of the total area (3044.5 km2) of the district is under sheet erosion followed by rill erosion 33.5 %, gully erosion 13.3% and ravenous erosion 0.4%. Highly degraded area, rock out crops is associated with higher elements of slope and barren areas accounts for 2.0%. The seasonal waterlogging is associated with lower elements of slope in depression where there is no facility for water to drain out through surface or sub-surface drainage and affecting agricultural activities which occupy 0.90% area in the district. Around 26.8 % area of the Jamui district is depicted as not affected due to degradation process due to its lower slopes

  2. West Texas geothermal resource assessment. Part II. Preliminary utilization assessment of the Trans-Pecos geothermal resource. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gilliland, M.W.; Fenner, L.B.

    1980-01-01

    The utilization potential of geothermal resources in Trans-Pecos, Texas was assessed. The potential for both direct use and electric power generation were examined. As with the resource assessment work, the focus was on the Hueco Tanks area in northeastern El Paso County and the Presidio Bolson area in Presidio County. Suitable users of the Hueco Tanks and Presidio Bolson resource areas were identified by matching postulated temperature characteristics of the geothermal resource to the need characteristics of existing users in each resource area. The amount of geothermal energy required and the amount of fossil fuel that geothermal energy would replace were calculated for each of the users identified as suitable. Current data indicate that temperatures in the Hueco Tanks resource area are not high enough for electric power generation, but in at least part of the Presidio Bolson resource area, they may be high enough for electric power generation.

  3. Health Impact Assessment of Air Pollution in Shiraz, Iran: a two-part study

    Directory of Open Access Journals (Sweden)

    Ehsan Gharehchahi

    2013-06-01

    Full Text Available We aimed to assess health-impacts of short-term exposure to the air pollutants including PM10, SO2, and NO2 in Shiraz, Iran in a two-part study from 2008 to 2010. In part I, local relative risks (RRs and baseline incidences (BIs were calculate using generalized additive models. In part II, we estimated the number of excess hospitalizations (NEHs due to cardiovascular diseases (CDs, respiratory diseases (RDs, respiratory diseases in elderly group (RDsE—people older than 65 years old, and chronic obstructive pulmonary diseases (COPDs as a result of exposure to air pollutants using AirQ model, which is proposed approach for air pollution health impact assessment by World Health Organization. In part I, exposure to increase in daily mean concentration of PM10 was associated with hospitalizations due to RDs with a RR of 1.0049 [95% confidence interval (CI, 1.0004 to 1.0110]. In addition, exposure to increase in daily mean concentration of SO2 and NO2 were associated with hospitalizations due to RDsE and COPDs with RRs of 1.0540 [95% CI, 1.0050 to 1.1200], 1.0950 [95% CI, 1.0700 to 1.1100], 1.0280 [95% CI, 1.0110 to 1.0450] and 1.0360 [95% CI, 1.0210 to 1.0510] per 10 μg/m3 rise of these pollutants, respectively. In part II, the maximum NEHs due to CDs because of exposure to PM10 were in 2009—1489 excess cases (ECs. The maximum NEHs due to RDs because of exposure to PM10 were in 2009—1163 ECs. Meanwhile, the maximum NEHs due to RDsE and COPDs because of exposure to SO2 were in 2008, which are 520 and 900 ECs, respectively. In conclusion, elevated morbidity risks were found from acute exposure to air pollutants.

  4. In situ lung perfusion is a valuable tool to assess lungs from donation after circulatory death donors category III

    NARCIS (Netherlands)

    Van de Wauwer, Caroline; Munneke, Anita J.; Engels, Gerwin E.; Berga, Foke M.; Rakhorst, Gerhard; Nijsten, Maarten W.; Mariani, Massimo A.; Erasmus, Michiel E.

    Donations after circulatory death (DCD) lung grafts are an alternative to extend the donor pool in lung transplantation. This study investigates the use of an in situ lung perfusion system (ISLP) in the donor to evaluate category III lungs. Pigs were sacrificed by ventricular fibrillation. All

  5. Optimizing protection for rear seat occupants : assessing booster performance with realistic belt geometry using the hybrid III 6YO ATD.

    Science.gov (United States)

    2011-11-01

    A series of sled tests was conducted to examine the performance of booster seats under belt geometries representing the range found in the rear seats of current vehicles. Twelve tests were performed with the standard 6YO Hybrid III ATD and 29 tests w...

  6. Geology of quadrangles H-12, H-13, and parts of I-12 and I-13, (zone III) in northeastern Santander Department, Colombia

    Science.gov (United States)

    Ward, Dwight Edward; Goldsmith, Richard; Cruz, Jaime B.; Restrepo, Hernan A.

    1974-01-01

    A program of geologic mapping and mineral investigation in Colombia was undertaken cooperatively by the Colombian Instituto Nacional de Investigaciones Geologico-Mineras (formerly known as the Inventario Minero Nacional), and the U. S. Geological Survey; by the Government of Colombia and the Agency for International Development, U. S. Department of State. The purpose was to study, and evaluate mineral resources (excluding of petroleum, coal, emeralds, and alluvial gold) of four selected areas, designated Zones I to IV, that total about 70,000 km2. The work in Zone III, in the Cordillera Oriental, was done from 1965 to 1968. The northeast trend of the Cordillera Oriental of Colombia swings abruptly to north-northwest in the area of this report, and divides around the southern end of the Maracaibo Basin. This section of the Cordillera Oriental is referred to as the Santander Massif. Radiometric age determinations indicate that the oldest rocks of the Santander massif are Precambrian and include high-grade gneiss, schist, and migmatite of the Bucaramanga Formation. These rocks were probably part of the Precambrian Guayana Shield. Low- to medium-grade metamorphic rocks of late Precambrian to Ordovician age .include phyllite, schist, metasiltstone, metasandstone, and marble of the Silgara Formation, a geosynclinal series of considerable extent in the Cordillera Oriental and possibly the Cordillera de Merida of Venezuela. Orthogneiss ranging from granite to tonalite is widely distributed in the high- and medium-grade metamorphic rocks of the central core of the massif and probably represents rocks of two ages, Precambrian and Ordovician to Early Devonian. Younger orthogneiss and the Silgara are overlain by Middle Devonian beds of the Floresta Formation which show a generally low but varying degree of metamorphism. Phyllite and argillite are common, and infrequent marble and other calcareous beds are fossiliferous. Except for recrystallization in limestones of !the

  7. Crescimento da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III: parte 1 Cranial base growth in different facial types in Class I, II and III orthopedic maxillomandibular relationship: part 1

    Directory of Open Access Journals (Sweden)

    Lucelma Vilela Pieri

    2007-02-01

    Full Text Available OBJETIVO: este estudo retrospectivo avaliou o crescimento médio anual da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III. METODOLOGIA: uma amostra aleatória de 300 pacientes brasileiros leucodermas (131 do gênero masculino, 169 do gênero feminino, com idade média inicial de 10 anos e 2 meses (dentadura mista e final de 14 anos e 8 meses (segundos molares em oclusão e tempo médio de observação de 4 anos e 5 meses, foi selecionada em uma clínica particular, em São Paulo, Brasil. Havia 118 Classe I, 151 Classe II e 31 Classe III. Todas as 600 radiografias cefalométricas laterais foram obtidas no mesmo aparelho de raios-x. As análises de Ricketts e Schwarz modificadas por Faltin foram usadas. As medidas lineares (Ba-Na, CC-Na, CC-Ba e CF-Po foram feitas pelo mesmo examinadora em T1 e T2. Os tipos faciais e de relacionamentos foram estudados juntos com a amostragem total e subdividida por gêneros. Os testes de Levene e t de Student foram aplicados. RESULTADOS E CONCLUSÕES: os resultados confirmaram os valores de Langlade, porém mostraram dimorfismo sexual, com o gênero masculino crescendo significativamente mais que o feminino. Este estudo será de grande aplicação para a previsão de crescimento, prognóstico e o plano de tratamento de pacientes em crescimento.AIM: to assess the cranial base annual mean growth in different facial types in Class I, II and III orthopedic maxillomandibular relationship. METHODS: a random sample of 300 Brazilian Caucasian patients (131 males, 169 females, with 10 years and 2 months (mixed dentition initial mean age, 14 years and 8 months (second molar occlusion final mean age and 4 years and 5 months mean observation time was selected at a private clinic in São Paulo - Brazil. There were 118 Class I, 151 Class II and 31 Class III. All 600 lateral cephalometric radiographs were taken using the same x-rays equipment. Ricketts and

  8. The functional architecture of the human body: assessing body representation by sorting body parts and activities.

    Science.gov (United States)

    Bläsing, Bettina; Schack, Thomas; Brugger, Peter

    2010-05-01

    We investigated mental representations of body parts and body-related activities in two subjects with congenitally absent limbs (one with, the other without phantom sensations), a wheelchair sports group of paraplegic participants, and two groups of participants with intact limbs. To analyse mental representation structures, we applied Structure Dimensional Analysis. Verbal labels indicating body parts and related activities were presented in randomized lists that had to be sorted according to a hierarchical splitting paradigm. Participants were required to group the items according to whether or not they were considered related, based on their own body perception. Results of the groups of physically intact and paraplegic participants revealed separate clusters for the lower body, upper body, fingers and head. The participant with congenital phantom limbs also showed a clear separation between upper and lower body (but not between fingers and hands). In the participant without phantom sensations of the absent arms, no such modularity emerged, but the specific practice of his right foot in communication and daily routines was reflected. Sorting verbal labels of body parts and activities appears a useful method to assess body representation in individuals with special body anatomy or function and leads to conclusions largely compatible with other assessment procedures.

  9. Three-dimensional assessment of mandibular and glenoid fossa changes after bone-anchored Class III intermaxillary traction.

    Science.gov (United States)

    De Clerck, Hugo; Nguyen, Tung; de Paula, Leonardo Koerich; Cevidanes, Lucia

    2012-07-01

    Conventional treatment for young Class III patients involves extraoral devices designed to either protract the maxilla or restrain mandibular growth. The use of skeletal anchorage offers a promising alternative to obtain orthopedic results with fewer dental compensations. Our aim was to evaluate 3-dimensional changes in the mandibles and the glenoid fossae of Class III patients treated with bone-anchored maxillary protraction. Twenty-five consecutive skeletal Class III patients between the ages of 9 and 13 years (mean age, 11.10 ± 1.1 year) were treated with Class III intermaxillary elastics and bilateral miniplates (2 in the infrazygomatic crests of the maxilla and 2 in the anterior mandible). The patients had cone-beam computed tomography images taken before initial loading and at the end of active treatment. Three-dimensional models were generated from these images, registered on the anterior cranial base, and analyzed by using color maps. Posterior displacement of the mandible at the end of treatment was observed in all subjects (posterior ramus: mean, 2.74 ± 1.36 mm; condyles: mean, 2.07 ± 1.16 mm; chin: mean, -0.13 ± 2.89 mm). Remodeling of the glenoid fossa at the anterior eminence (mean, 1.38 ± 1.03 mm) and bone resorption at the posterior wall (mean, -1.34 ± 0.6 mm) were observed in most patients. This new treatment approach offers a promising alternative to restrain mandibular growth for Class III patients with a component of mandibular prognathism or to compensate for maxillary deficiency in patients with hypoplasia of the midface. Future studies with long-term follow-up and comparisons with facemask and chincup therapies are needed to better understand the treatment effects. Copyright © 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  10. Proposed changes in personality and personality disorder assessment and diagnosis for DSM-5 part II: clinical application

    NARCIS (Netherlands)

    Skodol, A.E.; Bender, D.S.; Oldham, J.M.; Clark, L.A.; Morey, L.C.; Verheul, R.; Krueger, R.F.; Siever, L.J.

    2011-01-01

    The four-part assessment of personality psychopathology proposed for DSM-5 focuses attention on identifying personality psychopathology with increasing degrees of specificity, based on a clinician's available time, information, and expertise. In Part I of this two-part article, we described the

  11. Assessment of the Physicochemical Quality of Drinking Water Resources in the Central Part of Iran.

    Science.gov (United States)

    Nikaeen, Mahnaz; Shahryari, Ali; Hajiannejad, Mehdi; Saffari, Hossein; Kachuei, Zahra Moosavian; Hassanzadeh, Akbar

    2016-01-01

    The aim of the study described in this article was to assess the physicochemical quality of water resources in Isfahan province, located in the central part of Iran, from June to November 2012. Comparison of the results with the acceptable limits recommended by the World Health Organization (WHO) for drinking water showed that nitrate, chloride, iron, and fluoride concentrations exceeded the maximum acceptable level in 12.3%, 9.2%, 6.8%, and 1.5% of samples, respectively. Total dissolved solids (TDS) and turbidity values also exceeded the maximum acceptable level in 9.2% and 3.1% of samples, respectively. In general, the quality of drinking water resources in the central part of Iran at present is mostly acceptable and satisfactory. It may be deteriorated in the future, however, because water quantity and quality in arid and semiarid areas are highly variable over time. Therefore, continued monitoring of the water resources quality is extremely important to environmental safety.

  12. The Design of Research Laboratories. Part I: A General Assessment. Part II: Air Conditioning and Conditioned Rooms.

    Science.gov (United States)

    Legget, R. F.; Hutcheon, N. B.

    Design factors in the planning of research laboratories are described which include--(1) location, (2) future expansion, (3) internal flexibility, (4) provision of services, (5) laboratory furnishing, (6) internal traffic, (7) space requirements, and (8) building costs. A second part discusses air-conditioning and conditioned rooms--(1)…

  13. Economic Assessment of Supercritical CO2 Extraction of Waxes as Part of a Maize Stover Biorefinery

    OpenAIRE

    Attard, Thomas M.; Con Robert McElroy; Hunt, Andrew J.

    2015-01-01

    To date limited work has focused on assessing the economic viability of scCO2 extraction to obtain waxes as part of a biorefinery. This work estimates the economic costs for wax extraction from maize stover. The cost of manufacture (COM) for maize stover wax extraction was found to be €88.89 per kg of wax, with the fixed capital investment (FCI) and utility costs (CUT) contributing significantly to the COM. However, this value is based solely on scCO2 extraction of waxes and does not take int...

  14. Radiographic cephalometry assessment of the linear and angular parameters on cranial base in children with skeletal class III

    Directory of Open Access Journals (Sweden)

    Stojanović Zdenka M.

    2007-01-01

    Full Text Available Background/Aim. In malocclusion of skeletal class III, mandible is located in front of maxilla in sagital plain, which is manifested by a lower value of the sagital inter-jaw angle than in skeletal class I, where the jaw sagital relation is normal. Apart from the deformities on mandible and/or maxilla, in skeletal class III deformities are also frequent on the cranial base. The aim of this research was to find the differences in the parameter values on the cranial base among the children with skeletal class III and the children with skeletal class I in the period of mixed dentition. Methods. After clinical examination and orthopan-tomography, profile radiography of the head was analyzed in 60 examinees, aged from 6−12 years. The examinees were divided into two groups: group 1 - the children with skeletal class III; group 2 - the children with skeletal class I. Both linear and angular parameters on the cranial base were measured, as well as the angles of maxillary and mandible prognatism and the angle of sagital inter-jaw relation. The level of difference in the parameter values between the groups was estimated and the degree of correlation of the main angle of the cranial base with the angles of sagital position of the jaws in each of the two groups was established. Results. A significant difference between the groups was found only in the average values of the angles of maxillary prognatism and sagital interjaw relation. In the group 1, the main angle of the cranial base was in a significant correlation with the angles of sagital positions of the jaws, while in the group 2, such significance was not found. Conclusion. There were no significant differences in the parameter values on the cranial base between the groups. There was a significant correlation of the main angle of the cranial base with the angles of sagital position of the jaws in the group 1 only. .

  15. Assessing the potential hydrological impact of the Gibe III Dam on Lake Turkana water level using multi-source satellite data

    Science.gov (United States)

    Velpuri, N. M.; Senay, G. B.

    2012-10-01

    along the Lake Turkana shoreline that are vulnerable to fluctuations in lake levels due to the Gibe III dam were also identified. This study demonstrates the effectiveness of using existing multi-source satellite data in a basic modeling framework to assess the potential hydrological impact of an upstream dam on a terminal downstream lake. The results obtained from this study could also be used to evaluate alternative dam-filling scenarios and assess the potential impact of the dam on Lake Turkana under different operational strategies.

  16. Assessing the potential hydrological impact of the Gibe III Dam on Lake Turkana water level using multi-source satellite data

    Directory of Open Access Journals (Sweden)

    N. M. Velpuri

    2012-10-01

    dam commencement. Areas along the Lake Turkana shoreline that are vulnerable to fluctuations in lake levels due to the Gibe III dam were also identified. This study demonstrates the effectiveness of using existing multi-source satellite data in a basic modeling framework to assess the potential hydrological impact of an upstream dam on a terminal downstream lake. The results obtained from this study could also be used to evaluate alternative dam-filling scenarios and assess the potential impact of the dam on Lake Turkana under different operational strategies.

  17. ARFI ultrasound for in vivo hemostasis assessment postcardiac catheterization, part I: preclinical studies.

    Science.gov (United States)

    Behler, Russell H; Scola, Mallory R; Nichols, Timothy C; Bellinger, Dwight A; Gallippi, Caterina M

    2009-07-01

    The world wide prevalence of cardiovascular disease leads to over seven million annual percutaneous coronary catheterization procedures, the majority of which exploit femoral artery access. Femoral puncture sites ('arteriotomies') can be associated with severe vessel complications after sheath removal if hemostasis is not properly achieved. Hemostasis onset is routinely determined by examination for bleeding at the skin puncture; however, clotting along the puncture path can obscure subcutaneous bleeding, and therefore hemostasis is blindly assessed. We hypothesize that hemostasis assessment can be un-blinded by Acoustic Radiation Force Impulse (ARFI) ultrasound. In this first of a two-part series, we present in vivo ARFI hemostasis imaging data obtained in relevant canine models of femoral artery puncture. Above arteriotomies, ARFI-induced displacements were large (3.5 to >5.0 microm) relative to surrounding soft tissue soon after needle removal, which was consistent with our expectation for pooled extravasated blood. ARFI-induced displacements above arteriotomies decreased in magnitude (to approximately 2 microm) some time after needle removal and suggested the onset of hemostasis. This preclinical investigation served as proof of concept and justification for a pilot human study, which is presented in part two of this series.

  18. Parts-based stereoscopic image assessment by learning binocular manifold color visual properties

    Science.gov (United States)

    Xu, Haiyong; Yu, Mei; Luo, Ting; Zhang, Yun; Jiang, Gangyi

    2016-11-01

    Existing stereoscopic image quality assessment (SIQA) methods are mostly based on the luminance information, in which color information is not sufficiently considered. Actually, color is part of the important factors that affect human visual perception, and nonnegative matrix factorization (NMF) and manifold learning are in line with human visual perception. We propose an SIQA method based on learning binocular manifold color visual properties. To be more specific, in the training phase, a feature detector is created based on NMF with manifold regularization by considering color information, which not only allows parts-based manifold representation of an image, but also manifests localized color visual properties. In the quality estimation phase, visually important regions are selected by considering different human visual attention, and feature vectors are extracted by using the feature detector. Then the feature similarity index is calculated and the parts-based manifold color feature energy (PMCFE) for each view is defined based on the color feature vectors. The final quality score is obtained by considering a binocular combination based on PMCFE. The experimental results on LIVE I and LIVE Π 3-D IQA databases demonstrate that the proposed method can achieve much higher consistency with subjective evaluations than the state-of-the-art SIQA methods.

  19. Thermoanalytical study of linkage isomerism in coordination compounds. Part III: A DSC study on the effect of counterion on the solid state isomerization of nitro and nitrito linkage isomers of pentaamminecobalt(III) complexes

    Energy Technology Data Exchange (ETDEWEB)

    Eslami, Abbas, E-mail: eslami@umz.ac.ir; Hasani, Nahid

    2014-01-10

    Graphical abstract: - Highlights: • The effect of counterion on solid state thermal isomerization of nitro and nitrito linkage isomers of pentaamminecobalt(III) complexes studied by DSC. • The different prepared salts of both isomers are in metastable state at room temperature which convert to an equilibrium stale state upon heating. • Change of the counterion affects thermodynamic parameters of the isomerization reaction, but the nitro isomer is always more stable than the nitrito one. • The kinetic parameters of the linkage isomerization depend significantly on the nature of the counterion. - Abstract: Solid state thermal interconversion of [Co(NH{sub 3}){sub 5}NO{sub 2}]X{sub 2} (nitro isomer) and [Co(NH{sub 3}){sub 5}ONO]X{sub 2} (nitrito isomer) complexes (X = Cl{sup −}, Br{sup −}, I{sup −}, PF{sub 6}{sup −}) was studied by DSC at several heating rates. The isomerization of pure sample of both isomers leads to an equilibrium stable state in which nitro and nitrito isomers are major and minor components, respectively. Change of the counterion affects thermodynamic parameters of the isomerization reaction, but the nitro isomer is always more stable than the nitrito one. The equilibrium constant (nitro to nitrito molar ratio) increases in the series Cl{sup −} ≈ Br{sup −} < PF{sub 6}{sup −} < I{sup −}. The kinetic parameters of isomerization of both isomers were determined by Kissinger method. It was founded that the rate of interconversion of different salts of both isomers decreases in the series Cl{sup −} > Br{sup −} > PF{sub 6}{sup −} > I{sup −}. The negative activation entropy supports an associative mechanism with a seven coordinate transition state in solid state.

  20. The Effect of early physiotherapy on the recovery of mandibular function after orthognathic surgery for Class III correction: part I--jaw-motion analysis.

    Science.gov (United States)

    Teng, Terry Te-Yi; Ko, Ellen Wen-Ching; Huang, Chiung Shing; Chen, Yu-Ray

    2015-01-01

    The aim of this prospective study was to compare the mandibular range of motion in Class III patients with and without early physiotherapy after orthognathic surgery (OGS). This study consisted of 63 Class III patients who underwent 2-jaw OGS. The experimental group comprised 31 patients who received early systematic physical rehabilitation. The control group consisted of 32 patients who did not have physical rehabilitation. Twelve variables of 3-dimensional (3D) jaw-motion analysis (JMA) were recorded before surgery (T1) and 6 weeks (T2) and 6 months (T3) after surgery. A 2-sample t test was conducted to compare the JMA results between the two groups at different time points. At T2, the JMA data were measured to be 77.5%-145.7% of presurgical values in the experimental group, and 60.3%-90.6% in the control group. At T3, the measurements were 112.2%-179.2% of presurgical values in the experimental group, and 77.6%-157.2% in the control group. The patients in the experimental group exhibited more favorable recovery than did those in the control group, from T1 to T2 and T1 to T3. However, after termination of physiotherapy, no significant difference in the extent of recovery was observed between groups up to 6 months after OGS. Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  1. Comparative assessment of predictions in ungauged basins – Part 3: Runoff signatures in Austria

    Directory of Open Access Journals (Sweden)

    A. Viglione

    2013-06-01

    Full Text Available This is the third of a three-part paper series through which we assess the performance of runoff predictions in ungauged basins in a comparative way. Whereas the two previous papers by Parajka et al. (2013 and Salinas et al. (2013 assess the regionalisation performance of hydrographs and hydrological extremes on the basis of a comprehensive literature review of thousands of case studies around the world, in this paper we jointly assess prediction performance of a range of runoff signatures for a consistent and rich dataset. Daily runoff time series are predicted for 213 catchments in Austria by a regionalised rainfall–runoff model and by Top-kriging, a geostatistical estimation method that accounts for the river network hierarchy. From the runoff time-series, six runoff signatures are extracted: annual runoff, seasonal runoff, flow duration curves, low flows, high flows and runoff hydrographs. The predictive performance is assessed in terms of the bias, error spread and proportion of unexplained spatial variance of statistical measures of these signatures in cross-validation (blind testing mode. Results of the comparative assessment show that, in Austria, the predictive performance increases with catchment area for both methods and for most signatures, it tends to increase with elevation for the regionalised rainfall–runoff model, while the dependence on climate characteristics is weaker. Annual and seasonal runoff can be predicted more accurately than all other signatures. The spatial variability of high flows in ungauged basins is the most difficult to estimate followed by the low flows. It also turns out that in this data-rich study in Austria, the geostatistical approach (Top-kriging generally outperforms the regionalised rainfall–runoff model.

  2. Highly Sensitive Luminescence Assessment of Bile Acid Using a Balofloxacin-Europium(III) Probe in Micellar Medium

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Huan; Zhao, Fang; Si, Hailin; Zhang, Shuaishuai; Wang, Chunchun; Qi, Peirong [Shihezi Univ., Shihezi (China)

    2012-12-15

    A novel and simple method of luminescence enhancement effect for the determination of trace amounts of bile acid was proposed. The procedure was based on the luminescence intensity of the balofloxacin-europium(III) complex that could be strongly enhanced by bile acid in the presence of sodium dodecyl benzene sulfonate (SDBS). Under the optimum conditions, the enhanced luminescence intensity of the system exhibited a good linear relationship with the bile acid concentration in the range 5.0 Χ 10{sup -9} - 7.0 Χ 10{sup -7} mol L{sup -1} with a detection limit of 1.3 Χ 10{sup -9} mol L.1 (3σ). The relative standard deviation (RSD) was 1.7% (n = 11) for 5.0 Χ 10{sup -8} mol L{sup -1} bile acid. The applicability of the method to the determination of bile acid was demonstrated by investigating the effect of potential interferences and by analyzing human serum and urine samples. The possible enhancement mechanism of luminescence intensity in balofloxacin-europium(III)-bile acid-SDBS system was also discussed briefly.

  3. DECOVALEX III III/BENCHPAR PROJECTS. Approaches to Upscaling Thermal-Hydro-Mechanical Processes in a Fractured Rock. Mass and its Significance for Large-Scale Repository Performance Assessment. Summary of Findings. Report of BMT2/WP3

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan (comp.) [JA Streamflow AB, Aelvsjoe (Sweden); Staub, Isabelle (comp.) [Golder Associates AB, Stockholm (Sweden); Knight, Les (comp.) [Nirex UK Ltd, Oxon (United Kingdom)

    2005-02-15

    The Benchmark Test 2 of DECOVALEX III and Work Package 3 of BENCHPAR concerns the upscaling Thermal (T), Hydrological (H) and Mechanical (M) processes in a fractured rock mass and its significance for large-scale repository performance assessment. The work is primarily concerned with the extent to which various thermo-hydro-mechanical couplings in a fractured rock mass adjacent to a repository are significant in terms of solute transport typically calculated in large-scale repository performance assessments. Since the presence of even quite small fractures may control the hydraulic, mechanical and coupled hydromechanical behaviour of the rock mass, a key of the work has been to explore the extent to which these can be upscaled and represented by 'equivalent' continuum properties appropriate PA calculations. From these general aims the BMT was set-up as a numerical study of a large scale reference problem. Analysing this reference problem should: help explore how different means of simplifying the geometrical detail of a site, with its implications on model parameters, ('upscaling') impacts model predictions of relevance to repository performance, explore to what extent the THM-coupling needs to be considered in relation to PA-measures, compare the uncertainties in upscaling (both to uncertainty on how to upscale or uncertainty that arises due to the upscaling processes) and consideration of THM couplings with the inherent uncertainty and spatial variability of the site specific data. Furthermore, it has been an essential component of the work that individual teams not only produce numerical results but are forced to make their own judgements and to provide the proper justification for their conclusions based on their analysis. It should also be understood that conclusions drawn will partly be specific to the problem analysed, in particular as it mainly concerns a 2D application. This means that specific conclusions may have limited applicability

  4. Norm comparisons of the Spanish-language and English-language WAIS-III: Implications for clinical assessment and test adaptation.

    Science.gov (United States)

    Funes, Cynthia M; Rodriguez, Juventino Hernandez; Lopez, Steven Regeser

    2016-12-01

    This study provides a systematic comparison of the norms of 3 Spanish-language Wechsler Adult Intelligence Scales (WAIS-III) batteries from Mexico, Spain, and Puerto Rico, and the U.S. English-language WAIS-III battery. Specifically, we examined the performance of the 4 normative samples on 2 identical subtests (Digit Span and Digit Symbol-Coding) and 1 nearly identical subtest (Block Design). We found that across most age groups the means associated with the Spanish-language versions of the 3 subtests were lower than the means of the U.S. English-language version. In addition, we found that for most age ranges the Mexican subsamples scored lower than the Spanish subsamples. Lower educational levels of Mexicans and Spaniards compared to U.S. residents are consistent with the general pattern of findings. These results suggest that because of the different norms, applying any of the 3 Spanish-language versions of the WAIS-III generally risks underestimating deficits, and that applying the English-language WAIS-III norms risks overestimating deficits of Spanish-speaking adults. There were a few exceptions to these general patterns. For example, the Mexican subsample ages 70 years and above performed significantly better on the Digit Symbol and Block Design than did the U.S. and Spanish subsamples. Implications for the clinical assessment of U.S. Spanish-speaking Latinos and test adaptation are discussed with an eye toward improving the clinical care for this community. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  5. Noninvasive Assessment ofIDHMutational Status in World Health Organization Grade II and III Astrocytomas Using DWI and DSC-PWI Combined with Conventional MR Imaging.

    Science.gov (United States)

    Xing, Z; Yang, X; She, D; Lin, Y; Zhang, Y; Cao, D

    2017-06-01

    Isocitrate dehydrogenase ( IDH ) has been shown to have both diagnostic and prognostic implications in gliomas. The purpose of this study was to examine whether DWI and DSC-PWI combined with conventional MR imaging could noninvasively predict IDH mutational status in World Health Organization grade II and III astrocytomas. We retrospectively reviewed DWI, DSC-PWI, and conventional MR imaging in 42 patients with World Health Organization grade II and III astrocytomas. Minimum ADC, relative ADC, and relative maximum CBV values were compared between IDH -mutant and wild-type tumors by using the Mann-Whitney U test. Receiver operating characteristic curve and logistic regression were used to assess their diagnostic performances. Minimum ADC and relative ADC were significantly higher in IDH -mutated grade II and III astrocytomas than in IDH wild-type tumors ( P IDH mutation provided a sensitivity, specificity, positive predictive value, and negative predictive value of 100.0%, 60.9%, 85.6%, and 100.0%, respectively. A combination of DWI, DSC-PWI, and conventional MR imaging for the identification of IDH mutations resulted in a sensitivity, specificity, positive predictive value, and negative predictive value of 92.3%, 91.3%, 96.1%, and 83.6%. A combination of conventional MR imaging, DWI, and DSC-PWI techniques produces a high sensitivity, specificity, positive predictive value, and negative predictive value for predicting IDH mutations in grade II and III astrocytomas. The strategy of using advanced, semiquantitative MR imaging techniques may provide an important, noninvasive, surrogate marker that should be studied further in larger, prospective trials. © 2017 by American Journal of Neuroradiology.

  6. Petroleum resources assessment on the western part of the Kunsan Basin

    Energy Technology Data Exchange (ETDEWEB)

    Park, K.S.; Park, K.P.; Sunwoo, D.; Yoo, D.G.; Cheong, T.J.; Oh, J.H.; Bong, P.Y.; Son, J.D.; Lee, H.Y.; Ryu, B.J.; Son, B.K.; Hwang, I.G.; Kwon, Y.I.; Lee, Y.J.; Kim, H.J. [Korea Institute of Geology Mining and Materials, Taejon (Korea, Republic of)

    1997-12-01

    Palynomorphs including spores, pollen and organic-walled microfossils and calcareous microfossils such as ostracods, charophytes and gastropods were studied for the biostratigraphic work of Kachi-1 and IIH-1Xa wells. All the microfossils yielded from two wells indicate nonmarine environment ranging from shallow lacustrine to fluvial one. The paleoclimates have been fluctuated between subtropical and cool temperate with arid/humid alternating conditions. The fluvial sandstone of the interval between 2017 m and 2021 m could be a potential reservoir rock in the well Kachi-1. The sandstone from 1587 m to 1592 could be also a potential reservoir rock even if further study is necessary for the cap rock. Content of organic matter is very low and the type is compared to III in the section penetrated by the above two wells. Thermal maturity might reach top of oil window at depth about 1200 m by Tmax and about 1300 m by biomarker analysis in the Kachi-1 well. On the basis of illite crystallinity, the top of oil generation zone could be located at the depth 1600 m. The thermal maturity could not be determined in the IIH-1Xa well, because of the extremely low organic matter content or bad state of samples. Hydrocarbon genetic potential is almost null in the both well except for a few sample in the thermally immature interval. Analysis of approximately 3,300 Line-km of multichannel seismic data integrated with 3 well data provides an insight of structural evolution of the western part of the Yellow Sea Basin. Tectonics of the rifting phase have been established on the basis of structural and stratigraphic analyses of depositional sequences and their seismic expressions. Based on available well data, the rifting probably began in the Cretaceous time had continued until Paleocene. It is considered that compressional force immediately after rifting event deformed sedimentary sections. During the period of Paleocene to middle Miocene, the sediments were deposited in stable

  7. Assessing EEG sleep spindle propagation. Part 1: theory and proposed methodology.

    Science.gov (United States)

    O'Reilly, Christian; Nielsen, Tore

    2014-01-15

    A convergence of studies has revealed sleep spindles to be associated with sleep-related cognitive processing and even with fundamental waking state capacities such as intelligence. However, some spindle characteristics, such as propagation direction and delay, may play a decisive role but are only infrequently investigated because of technical complexities. A new methodology for assessing sleep spindle propagation over the human scalp using noninvasive electroencephalography (EEG) is described. This approach is based on the alignment of time-frequency representations of spindle activity across recording channels. This first of a two-part series concentrates on framing theoretical considerations related to EEG spindle propagation and on detailing the methodology. A short example application is provided that illustrates the repeatability of results obtained with the new propagation measure in a sample of 32 night recordings. A more comprehensive experimental investigation is presented in part two of the series. Compared to existing methods, this approach is particularly well adapted for studying the propagation of sleep spindles because it estimates time delays rather than phase synchrony and it computes propagation properties for every individual spindle with windows adjusted to the specific spindle duration. The proposed methodology is effective in tracking the propagation of spindles across the scalp and may thus help in elucidating the temporal aspects of sleep spindle dynamics, as well as other transient EEG and MEG events. A software implementation (the Spyndle Python package) is provided as open source software. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Richard III

    DEFF Research Database (Denmark)

    Lauridsen, Palle Schantz

    2017-01-01

    Kort analyse af Shakespeares Richard III med fokus på, hvordan denne skurk fremstilles, så tilskuere (og læsere) langt henad vejen kan føle sympati med ham. Med paralleller til Netflix-serien "House of Cards"......Kort analyse af Shakespeares Richard III med fokus på, hvordan denne skurk fremstilles, så tilskuere (og læsere) langt henad vejen kan føle sympati med ham. Med paralleller til Netflix-serien "House of Cards"...

  9. Technical reliability of geological disposal for high-level radioactive wastes in Japan. The second progress report. Part 3. Safety assessment for geological disposal systems

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    Based on the Advisory Committee Report on Nuclear Fuel Cycle Backend Policy submitted to the Japanese Government in 1997, JNC documents the progress of research and development program in the form of the second progress report (the first one published in 1992). It summarizes an evaluation of the technical reliability and safety of the geological disposal concept for high-level radioactive wastes (HLW) in Japan. The present document, the part 3 of the progress report, concerns safety assessment for geological disposal systems definitely introduced in part 1 and 2 of this series and consists of 9 chapters. Chapter I concerns the methodology for safety assessment while Chapter II deals with diversity and uncertainty about the scenario, the adequate model and the required data of the systems above. Chapter III summarizes the components of the geological disposal system. Chapter IV refers to the relationship between radioactive wastes and human life through groundwater, i.e. nuclide migration. In Chapter V is made a reference case which characterizes the geological environmental data using artificial barrier specifications. (Ohno. S.)

  10. Human Body Parts Tracking and Kinematic Features Assessment Based on RSSI and Inertial Sensor Measurements

    Directory of Open Access Journals (Sweden)

    Gaddi Blumrosen

    2013-08-01

    Full Text Available Acquisition of patient kinematics in different environments plays an important role in the detection of risk situations such as fall detection in elderly patients, in rehabilitation of patients with injuries, and in the design of treatment plans for patients with neurological diseases. Received Signal Strength Indicator (RSSI measurements in a Body Area Network (BAN, capture the signal power on a radio link. The main aim of this paper is to demonstrate the potential of utilizing RSSI measurements in assessment of human kinematic features, and to give methods to determine these features. RSSI measurements can be used for tracking different body parts’ displacements on scales of a few centimeters, for classifying motion and gait patterns instead of inertial sensors, and to serve as an additional reference to other sensors, in particular inertial sensors. Criteria and analytical methods for body part tracking, kinematic motion feature extraction, and a Kalman filter model for aggregation of RSSI and inertial sensor were derived. The methods were verified by a set of experiments performed in an indoor environment. In the future, the use of RSSI measurements can help in continuous assessment of various kinematic features of patients during their daily life activities and enhance medical diagnosis accuracy with lower costs.

  11. Methods for collecting algal samples as part of the National Water-Quality Assessment Program

    Science.gov (United States)

    Porter, Stephen D.; Cuffney, Thomas F.; Gurtz, Martin E.; Meador, Michael R.

    1993-01-01

    Benthic algae (periphyton) and phytoplankton communities are characterized in the U.S. Geological Survey's National Water-Quality Assessment Program as part of an integrated physical, chemical, and biological assessment of the Nation's water quality. This multidisciplinary approach provides multiple lines of evidence for evaluating water-quality status and trends, and for refining an understanding of the factors that affect water-quality conditions locally, regionally, and nationally. Water quality can be characterized by evaluating the results of qualitative and quantitative measurements of the algal community. Qualitative periphyton samples are collected to develop of list of taxa present in the sampling reach. Quantitative periphyton samples are collected to measure algal community structure within selected habitats. These samples of benthic algal communities are collected from natural substrates, using the sampling methods that are most appropriate for the habitat conditions. Phytoplankton samples may be collected in large nonwadeable streams and rivers to meet specific program objectives. Estimates of algal biomass (chlorophyll content and ash-free dry mass) also are optional measures that may be useful for interpreting water-quality conditions. A nationally consistent approach provides guidance on site, reach, and habitat selection, as well as information on methods and equipment for qualitative and quantitative sampling. Appropriate quality-assurance and quality-control guidelines are used to maximize the ability to analyze data locally, regionally, and nationally.

  12. Evaluation of triclosan in Minnesota lakes and rivers: Part I - ecological risk assessment.

    Science.gov (United States)

    Lyndall, Jennifer; Barber, Timothy; Mahaney, Wendy; Bock, Michael; Capdevielle, Marie

    2017-08-01

    Triclosan, an antimicrobial compound found in consumer products, may be introduced into the aquatic environment via residual concentrations in municipal wastewater treatment effluent. We conducted an aquatic risk assessment that incorporated the available measured triclosan data from Minnesota lakes and rivers. Although only data reported from Minnesota were considered in the risk assessment, the developed toxicity benchmarks can be applied to other environments. The data were evaluated using a series of environmental fate models to ensure the data were internally consistent and to fill any data gaps. Triclosan was not detected in over 75% of the 567 surface water and sediment samples. Measured environmental data were used to model the predicted environmental exposures to triclosan in surface water, surface sediment, and biota tissues. Toxicity benchmarks based on fatty acid synthesis inhibition and narcosis were determined for aquatic organisms based, in part, on a species sensitivity distribution of chronic toxicity thresholds from the available literature. Predicted and measured environmental concentrations for surface water, sediment, and tissue were below the effects benchmarks, indicating that exposure to triclosan in Minnesota lakes and rivers would not pose an unacceptable risk to aquatic organisms. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. AMEE Guide 32: e-Learning in medical education Part 1: Learning, teaching and assessment.

    Science.gov (United States)

    Ellaway, Rachel; Masters, Ken

    2008-06-01

    In just a few years, e-learning has become part of the mainstream in medical education. While e-learning means many things to many people, at its heart it is concerned with the educational uses of technology. For the purposes of this guide, we consider the many ways that the information revolution has affected and remediated the practice of healthcare teaching and learning. Deploying new technologies usually introduces tensions, and e-learning is no exception. Some wish to use it merely to perform pre-existing activities more efficiently or faster. Others pursue new ways of thinking and working that the use of such technology affords them. Simultaneously, while education, not technology, is the prime goal (and for healthcare, better patient outcomes), we are also aware that we cannot always predict outcomes. Sometimes, we have to take risks, and 'see what happens.' Serendipity often adds to the excitement of teaching. It certainly adds to the excitement of learning. The use of technology in support of education is not, therefore, a causal or engineered set of practices; rather, it requires creativity and adaptability in response to the specific and changing contexts in which it is used. Medical Education, as with most fields, is grappling with these tensions; the AMEE Guide to e-Learning in Medical Education hopes to help the reader, whether novice or expert, navigate them. This Guide is presented both as an introduction to the novice, and as a resource to more experienced practitioners. It covers a wide range of topics, some in broad outline, and others in more detail. Each section is concluded with a brief 'Take Home Message' which serves as a short summary of the section. The Guide is divided into two parts. The first part introduces the basic concepts of e-learning, e-teaching, and e-assessment, and then focuses on the day-to-day issues of e-learning, looking both at theoretical concepts and practical implementation issues. The second part examines technical

  14. Orthopedic treatment of Class III malocclusion with rapid maxillary expansion combined with a face mask: a cephalometric assessment of craniofacial growth patterns

    Directory of Open Access Journals (Sweden)

    Daniella Torres Tagawa

    2012-06-01

    Full Text Available OBJECTIVE: The aim of this prospective study was to assess potential changes in the cephalometric craniofacial growth pattern of 17 children presenting Angle Class III malocclusion treated with a Haas-type expander combined with a face mask. METHODS: Lateral cephalometric radiographs were taken at beginning (T1 and immediately after removal of the appliances (T2, average of 11 months of treatment. Linear and angular measurements were used to evaluate the cranial base, dentoskeletal changes and facial growth pattern. RESULTS: The length of the anterior cranial base experienced a reduction while the posterior cranial base assumed a more vertical position at T1. Some maxillary movement occurred, there was no rotation of the palatal plane, there was a slight clockwise rotation of the mandible, although not significant. The ANB angle increased, thereby improving the relationship between the jaws; dentoalveolar compensation was more evident in the lower incisors. Five out of 12 cases (29.41% showed the following changes: In one case the pattern became more horizontal and in four cases more vertical. CONCLUSIONS: It was concluded after a short-term assessment that treatment with rapid maxillary expansion (RME associated with a face mask was effective in the correction of Class III malocclusion despite the changes in facial growth pattern observed in a few cases.

  15. Comparison of in-person and digital photograph assessment of stage III and IV pressure ulcers among veterans with spinal cord injuries.

    Science.gov (United States)

    Terris, Darcey D; Woo, Christine; Jarczok, Marc N; Ho, Chester H

    2011-01-01

    Digital photographs are often used in treatment monitoring for home care of less advanced pressure ulcers. We investigated assessment agreement when stage III and IV pressure ulcers in individuals with spinal cord injury were evaluated in person and with the use of digital photographs. Two wound-care nurses assessed 31 wounds among 15 participants. One nurse assessed all wounds in person, while the other used digital photographs. Twenty-four wound description categories were applied in the nurses' assessments. Kappa statistics were calculated to investigate agreement beyond chance (p < or = 0.05). For 10 randomly selected "double-rated wounds," both nurses applied both assessment methods. Fewer categories were evaluated for the double-rated wounds, because some categories were chosen infrequently and agreement could not be measured. Interrater agreement with the two methods was observed for 12 of the 24 categories (50.0%). However, of the 12 categories with agreement beyond chance, agreement was only "slight" (kappa = 0-0.20) or "fair" (kappa = 0.21-0.40) for 6 categories. The highest agreement was found for the presence of undermining (kappa = 0.853, p < 0.001). Interrater agreement was similar to intramethod agreement (41.2% of the categories demonstrated agreement beyond chance) for the nurses' in-person assessment of the double-rated wounds. The moderate agreement observed may be attributed to variation in subjective perception of qualitative wound characteristics.

  16. Safety studies on Korean fusion DEMO plant using Integrated Safety Assessment Methodology: Part 2

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Kyemin; Kang, Myoung-suk [Kyung Hee University, Yongin-si, Gyeonggi-do 446-701 (Korea, Republic of); Heo, Gyunyoung, E-mail: gheo@khu.ac.kr [Kyung Hee University, Yongin-si, Gyeonggi-do 446-701 (Korea, Republic of); Kim, Hyoung-chan [National Fusion Research Institute, Daejeon-si 305-333 (Korea, Republic of)

    2015-10-15

    Highlights: • The purpose of this paper is to suggest methodology that can investigate safety issues and provides a case study for Korean fusion DEMO plant. • The concepts of Integrated Safety Assessment Methodology (ISAM) that can be applied in addressing regulatory requirements and recognizing safety issues for K-DEMO were emphasized. • Phenomena Identification Ranking Table (PIRT) and Objective Provision Tree (OPT) were performed and updated. • This work is expected to contribute on the conceptual design of safety features for K-DEMO to design engineers and the guidance for regulatory requirements to licensers. - Abstract: The purpose of this paper is to investigate safety issues using Integrated Safety Assessment Methodology (ISAM) proposed by Generation IV Forum Risk and Safety Working Group (RSWG) for Korean fusion DEMO plant (K-DEMO). In ongoing nuclear energy research such as Generation IV fission power plant (GEN-IV), new methodology based on Technology-Neutral Framework (TNF) has been applied for safety assessment. In this methodology, design and regulatory requirements for safety of nuclear power plants are considered simultaneously. The design based on regulatory requirements can save resource, time, and manpower while maintaining high level safety. ISAM is one of the options to apply TNF in K-DEMO. We have performed safety studies for K-DEMO using Phenomena Identification and Ranking Table (PIRT) and Objective Provision Tree (OPT) which are constitutive part of ISAM. Considering the design phase of K-DEMO, the current study focused on PIRT and OPT for K-DEMO. Results have been reviewed and updated by Korean fusion advisory group after considering the views of specialists from domestic universities, industries, and national institutes in South Korea.

  17. Howard Gardner: Aportes de la investigación psicológica a la educación actual : Parte III

    OpenAIRE

    Gómez, María Florencia

    2016-01-01

    Como afirmamos en las publicaciones previas del tema de este mes, Howard Gardner es hoy un especialista citado en distintos posts, comentarios, presentaciones e infografías sobre el uso de recursos tecnológicos en educación. En esta parte presentaremos su estudio sobre la App Generation.

  18. Support of the Ukrainean Supervisory Authority during the extension of the improved operational NCP monitoring. Final report part III; Unterstuetzung der ukrainischen Aufsichtsbehoerde beim Ausbau der verbesserten betrieblichen KKW-Ueberwachung. Abschlussbericht Teil III

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, M.; Carl, H.

    2005-05-01

    Technical systems to improve the operational monitoring for the three units of the South Ukraine NPP and for the 1{sup st} unit of the Chmelnitzky NPP were put up by analogy with the systems for the Zaporoshye NPP and the Rovno NPP. For that up to 51 safety-relevant technological and 16 radiological parameters from every unit are available to the supervisory authority on-site and in the crisis centre in Kiev for collection and assessment. These parameters are transferred on-line by modern technical equipment once a minute. The developed evaluation software enables the visualisation of the monitoring results in form of diagrams, charts and graphs. By means of an archive modus the trends of all parameters can be analysed. With the integration of the technical equipment delivered for the sheltered room of the Zaporoshye NPP into the on-site existing remote monitoring system is it now possible to record and to evaluate essential safety-relevant parameters of the whole NPP also during severe accidents by means of modern technical equipment. (orig.)

  19. Uptake of iron (III)-ethylenediamine-N,N,N',N'-tetraacetic acid complex by phosphatidylcholine lipid film: Part I. Effect of bulk pH.

    Science.gov (United States)

    Villeneuve, Masumi; Tanaka, Mihoko; Saito, Natsumi; Sakamoto, Hiroyasu; Hayami, Yoshiteru

    2017-12-06

    We studied a ternary solutes aqueous solution of NaOH, iron (III)-ethylenediamine-N,N,N',N'-tetraacetic acid complex (Fe-edta), and 1,2-diheptanoyl-sn-glycero-3-phosphatidylcholine (DHPC)/air interface system to clarify the interactions between iron complexes and lipids with a phosphatidylcholine head group. The solution surface tension and pH were measured as functions of the total molality of NaOH, Fe-edta and DHPC, and the mole fractions of NaOH and DHPC. Rigorous thermodynamic equations were derived, in which the overall proton dissociation equilibria of Fe-edta and DHPC were taken into consideration, and applied to experimental data to obtain phase diagram of adsorption. It was found that (1) adsorption of Fe-edta at the solution/air interface with a DHPC monolayer was about 50-130 times higher than that without a DHPC monolayer and (2) when the bulk mole fraction of NaOH was high, Fe-edta tended to be expelled from the adsorbed film. The last finding suggests that the ambient pH significantly affects passive transport of the iron complex through a phospholipid-containing membrane into the cell interior. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Simulación de la fluencia en caliente de un acero microaleado con un contenido medio de carbono. III parte. Ecuaciones constitutivas

    Directory of Open Access Journals (Sweden)

    Cabrera, J. M.

    1997-08-01

    Full Text Available According to the part 1 of this work the constitutive equations of the hot flow behaviour of a commercial microalloyed steel have been obtained. For this purpose, the uniaxial hot compression tests described in the part 2 were employed. Tests were carried out over a range of 5 orders of magnitude in strain rate and 300 °C of temperature. Experimental results are compared with the theoretical model introduced in the first part of this study. It is concluded that deviations between experimental and theoretical curves are lower than 10 %. It is shown that the classical hiperbolic sine constitutive equation described accurately the experimental behaviour provided that stresses are normalized by the Young's modulus and strain rates by the self-diffusion coefficient. An internal stress must also be introduced in the latter equation when the initial grain size is fine enough.

    Siguiendo el planteamiento teórico efectuado en la I parte de este trabajo, se determinaron las ecuaciones constitutivas del comportamiento a la deformación en caliente de un acero comercial microaleado con un contenido medio de carbono. Para este objetivo se emplearon los ensayos de compresión uniaxial en caliente ya descritos en la II parte, los cuales se efectuaron en un rango de cinco órdenes de magnitud en velocidad de deformación y 300 °C de temperatura. Se comparan los resultados experimentales con el modelo teórico introducido en la I parte y se verifica que el error es inferior al 10 %. Se comprobó que la clásica ecuación del seno hiperbólico podía describir con precisión el comportamiento observado siempre y cuando las tensiones se normalicen por el módulo de Young, las velocidades de deformación por el coeficiente de autodifusión de la austenita, y se considere un efecto adicional sobre la tensión cuando el tamaño de grano inicial sea suficientemente fino.

  1. The KULTURisk Regional Risk Assessment methodology for water-related natural hazards - Part 1: Physical-environmental assessment

    Science.gov (United States)

    Ronco, P.; Gallina, V.; Torresan, S.; Zabeo, A.; Semenzin, E.; Critto, A.; Marcomini, A.

    2014-12-01

    , exposure and vulnerability. It integrates the outputs of various hydrodynamic models with site-specific bio-geophysical and socio-economic indicators (e.g. slope, land cover, population density, economic activities etc.) to develop tailored risk indexes and GIS-based maps for each of the selected receptors (i.e. people, buildings, infrastructure, agriculture, natural and semi-natural systems, cultural heritage) in the considered region. It further compares the baseline scenario with alternative scenarios, where different structural and/or non-structural mitigation measures are planned and eventually implemented. As demonstrated in the companion paper (Part 2, Ronco et al., 2014), risk maps, along with related statistics, allow one to identify and classify, on a relative scale, areas at risk which are more likely to be affected by floods and support the development of strategic adaptation and prevention measures to minimizing flood impacts. In addition, the outcomes of the RRA can be eventually used for a further socio-economic assessment, considering the tangible and intangible costs as well as the human dimension of vulnerability.

  2. A chronic plant test for the assessment of contaminated soils. Part 2. Testing of contaminated soils

    Energy Technology Data Exchange (ETDEWEB)

    Junker, T.; Roembke, J. [ECT Oekotoxikologie GmbH, Floersheim (Germany); Kalsch, W.

    2006-06-15

    Background and scope. A new chronic plant test system which is based on experiences with various acute plant tests (e.g. published by OECD or ISO) and existing north American plant-life-cycle bioassays was standardised in a project sponsored by the German government. Characteristic properties of the test system, which can be performed either with Brassica rapa (turnip rape) or Avena sativa (oat), are described in part 1 of this mini-series. Methods. This new test was used to assess the effects of natural soil samples contaminated with TNT (2,4,6-Trinitrotoluene) or PAHs (poly-aromatic hydrocarbons). The soils were tested after taken from the field as well as after being remediated. Different control and reference soils were used to evaluate the test results. In addition, they were compared with the results of tests in which either TNT or Pyrene were spiked to field and standard soils (see part 1 of this mini-series). Results. All contaminated soils showed clear effects in the chronic plant test (usually B. rapa was more sensitive than A. sativa). LUFA 2.2 standard soil and OECD artificial soil are well-suited as control and mixture substrates, while reference soils collected at uncontaminated sites were several times as phytotoxic. In most of the latter cases, soil properties could be identified as the main cause of these effects (e.g. the pH value). While the sensitivity of the reproduction and biomass endpoints did not differ much in general, it is recommended to measure different endpoints (i.e. biomass and reproduction) due to the different mode-of-action of contaminants. In the case of TNT, a good agreement between the results of single chemical tests and tests with TNT-contaminated soils was found (due to the minimal effects of Pyrene, the same statement is not possible for PAHs). (orig.)

  3. Good practice criteria and improving infrastructure for leisure-time physical activity in the local arena - the Impala project, part iii.

    Directory of Open Access Journals (Sweden)

    Jana Vašíčková

    2013-03-01

    Full Text Available BACKGROUND: This project is aimed at unifying information about local infrastructure for leisure-time physical activity (LTPA in twelve European countries. This is due to the exchange of information about national strategies, policies, and mechanism at working meetings. This also includes their improvement with regard to social inequalities, inter-sectoral cooperation and participation. AIM: The aim of the third part of the IMPALA project is to summarize the results of the project into certain fundamental criteria that can be used by regional and local policy and stakeholders who can participate in planning, financing, building or managing of infrastructure for LTPA. METHODS: Based on identification of national strategies and policies (1st part of the project as well as mechanisms (2nd part of the project, we identified examples of positive practice in each of the participating countries in the sphere of LTPA infrastructures. To find out this information we used qualitative methods, namely structured interviews, focus group method, and brainstorming among relevant people who were involved into the project on national levels. RESULTS: The main outcome of the project are the guidelines that are drawn up as a list of criteria for evaluation of contemporary situations within the sphere of policy, planning, financing, building and managing of LTPA infrastructures. Another integral part that follows evaluation criteria are proposals for improving the mentioned spheres regarding to equality of approaches, inter-sectoral cooperation and participation of concerned parties. The appendix contains examples of practice that were chosen within the project from all of the participating countries and represent a certain sphere such as planning, building, financing or management. CONCLUSION: The main results of the project are: relevance of infrastructure and public physical activity connectivity; searching for the possibility to widely use the existing

  4. Scientific and regulatory policy committee (SRPC) paper: Assessment of Circulating Hormones in Nonclinical Toxicity Studies. III Female Reproductive Hormones

    Science.gov (United States)

    Hormonally mediated effects on the female reproductive system may manifest in pathologic changes of endocrine-responsive organs and altered reproductive function. Identification of these effects requires proper assessment, which may include investigative studies of female reprod...

  5. The effect of early physiotherapy on the recovery of mandibular function after orthognathic surgery for class III correction. Part II: electromyographic activity of masticatory muscles.

    Science.gov (United States)

    Ko, Ellen Wen-Ching; Teng, Terry Te-Yi; Huang, Chiung Shing; Chen, Yu-Ray

    2015-01-01

    The study was conducted to evaluate the effect of early physical rehabilitation by comparing the differences of surface electromyographic (sEMG) activity in the masseter and anterior temporalis muscles after surgical correction of skeletal class III malocclusion. The prospective study included 63 patients; the experimental groups contained 31 patients who received early systematic physical rehabilitation; the control group (32 patients) did not receive physiotherapy. The amplitude of sEMG in the masticatory muscles reached 72.6-121.3% and 37.5-64.6% of pre-surgical values in the experimental and control groups respectively at 6 weeks after orthognathic surgery (OGS). At 6 months after OGS, the sEMG reached 135.1-233.4% and 89.6-122.5% of pre-surgical values in the experimental and control groups respectively. Most variables in the sEMG examination indicated that recovery of the masticatory muscles in the experimental group was better than the control group as estimated in the early phase (T1 to T2) and the total phase (T1 to T3); there were no significant differences between the mean recovery percentages in the later phase (T2 to T3). Early physical rehabilitative therapy is helpful for early recovery of muscle activity in masticatory muscles after OGS. After termination of physical therapy, no significant difference in recovery was indicated in patients with or without early physiotherapy. Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  6. Protocol Outlines for Parts 1 and 2 of the Prospective Endoscopy III Study for the Early Detection of Colorectal Cancer: Validation of a Concept Based on Blood Biomarkers.

    Science.gov (United States)

    Rasmussen, Louise; Wilhelmsen, Michael; Christensen, Ib Jarle; Andersen, Jens; Jørgensen, Lars Nannestad; Rasmussen, Morten; Hendel, Jakob W; Madsen, Mogens R; Vilandt, Jesper; Hillig, Thore; Klærke, Michael; Münster, Anna-Marie Bloch; Andersen, Lars M; Andersen, Berit; Hornung, Nete; Erlandsen, Erland J; Khalid, Ali; Nielsen, Hans Jørgen

    2016-09-13

    Programs for population screening of colorectal cancer (CRC) have been implemented in several countries with fecal immunochemical testing (FIT) as the preferred platform. However, the major obstacle for a feces-based testing method is the limited compliance that reduces the clinical sensitivity for detection of participants with non-symptomatic CRC. Therefore, research approaches have been initiated to develop screening concepts based on biomarkers in blood. Preliminary results show that protein, genetic, epigenetic, and metabolomic components may be valuable in blood-based screening concepts, particularly when combinations of the various components appear to lead to significant improvements. The protocol described in this paper focuses on the validation of concepts based on biomarkers in blood in a major population screened by FIT. In Part 1, participants will be identified and included through the Danish CRC Screening Program comprising initial FIT and subsequent colonoscopy to those with a positive result. Blood samples will be collected from 8000 FIT-positive participants, who are offered subsequent colonoscopy. Findings and interventions at colonoscopy together with personal data including co-morbidity will be recorded. Blood samples and data will also be collected from 6000 arbitrarily chosen participants with negative FIT. In Part 2, blood samples and data will be collected from 30,000 FIT-negative participants three times within 4 years. The blood samples will be analyzed using various in-house and commercially available manual and automated analysis platforms. We anticipate Part 1 to terminate late August 2016 and Part 2 to terminate late September 2022. The results from Parts 1 and 2 will be presented within 12 to 18 months from termination. The purpose of this study is to improve the efficacy of identifying participants with neoplastic bowel lesions, to identify false negative participants, to identify participants at risk of interval neoplastic lesions

  7. The removal of toxic metals from liquid effluents by ion exchange resins. Part IV: Chromium(III)/H+ /Lewatit SP112; La eliminación de metales tóxicos presentes en efluentes líquidos mediante resinas de cambio iónico. Parte IV: cromo(III)/H+/Lewatit SP112

    Energy Technology Data Exchange (ETDEWEB)

    Alguacil, F.J.

    2017-09-01

    This investigation presented results on the removal of chromium(III), from aqueous solution in the 0-5 pH range, using Lewatit SP112 cationic exchange resin. Several aspects affecting the ion exchange process were evaluated, including: the influence of the stirring speed, temperature, pH of the solution, resin dosage and aqueous ionic strength. The selectivity of the system was tested against the presence of other metals in the aqueous solution, whereas the removal of chromium(III) from solutions was compared with results obtained using multiwalled carbon nanotubes as adsorbents. From the batch experimental data, best fit of the results is obtained with the Langmuir model, whereas the ion exchange process is best explained by the pseudo-second order model, moreover, experimental data responded well to the film-diffusion controlled model. Elution of the chromium(III) loaded into the resin is well accomplished by the use of sodium hydroxide solutions. [Spanish] En este trabajo se presentan los resultados obtenidos en la eliminación de cromo(III) de disoluciones acuosas (pH 0-5) mediante la resina de intercambio catiónico Lewatit SP112. Se han investigado algunas variables que pueden afectar al sistema: influencia de la agitación, temperatura, pH y fuerza iónica del medio acuoso y cantidad de resina; también se ha investigado acerca de la selectividad del sistema cuando otros metales están presentes en el medio acuoso, comparándose los resultados de la eliminación del cromo(III) usando la resina con los resultados obtenidos cuando se emplea otro adsorbente como son los nanotubos de carbono de pared múltiple. Los resultados experimentales indican que la carga del cromo(III) en la resina responde mejor al modelo de Langmuir, mientras que los modelos cinéticos indican que la carga del metal en la resina responde al modelo de pseudo-segundo orden y difusión en la capa límite. La elución del cromo(III) se realiza con disoluciones de hidróxid.

  8. Cone-Beam Computed Tomography Assessment of Lower Facial Asymmetry in Unilateral Cleft Lip and Palate and Non-Cleft Patients with Class III Skeletal Relationship.

    Directory of Open Access Journals (Sweden)

    Yifan Lin

    Full Text Available To evaluate, using cone-beam computed tomography (CBCT, both the condylar-fossa relationships and the mandibular and condylar asymmetries between unilateral cleft lip and palate (UCLP patients and non-cleft patients with class III skeletal relationship, and to investigate the factors of asymmetry contributing to chin deviation.The UCLP and non-cleft groups consisted of 30 and 40 subjects, respectively, in mixed dentition with class III skeletal relationships. Condylar-fossa relationships and the dimensional and positional asymmetries of the condyles and mandibles were examined using CBCT. Intra-group differences were compared between two sides in both groups using a paired t-test. Furthermore, correlations between each measurement and chin deviation were assessed.It was observed that 90% of UCLP and 67.5% of non-cleft subjects had both condyles centered, and no significant asymmetry was found. The axial angle and the condylar center distances to the midsagittal plane were significantly greater on the cleft side than on the non-cleft side (P=0.001 and P=0.028, respectively and were positively correlated with chin deviation in the UCLP group. Except for a larger gonial angle on the cleft side, the two groups presented with consistent asymmetries showing shorter mandibular bodies and total mandibular lengths on the cleft (deviated side. The average chin deviation was 1.63 mm to the cleft side, and the average absolute chin deviation was significantly greater in the UCLP group than in the non-cleft group (P=0.037.Compared with non-cleft subjects with similar class III skeletal relationships, the subjects with UCLP showed more severe lower facial asymmetry. The subjects with UCLP presented with more asymmetrical positions and rotations of the condyles on axial slices, which were positively correlated with chin deviation.

  9. Children's exposure to indoor air in urban nurseries--Part II: Gaseous pollutants' assessment.

    Science.gov (United States)

    Branco, P T B S; Nunes, R A O; Alvim-Ferraz, M C M; Martins, F G; Sousa, S I V

    2015-10-01

    This study, Part II of the larger study "Children's exposure to indoor air in urban nurseries", aimed to: (i) evaluate nursery schools' indoor concentrations of several air pollutants in class and lunch rooms; and (ii) analyse them according to guidelines and references. Indoor continuous measurements were performed, and outdoor concentrations were obtained to determine indoor/outdoor ratios. The influence of outdoor air seemed to be determinant on carbon monoxide (CO), nitrogen dioxide (NO2) and ozone (O3) indoor concentrations. The peak concentrations of formaldehyde and volatile organic compounds (VOC) registered (highest concentrations of 204 and 2320 µg m(-3) respectively), indicated the presence of specific indoor sources of these pollutants, namely materials emitting formaldehyde and products emitting VOC associated to cleaning and children's specific activities (like paints and glues). For formaldehyde, baseline constant concentrations along the day were also found in some of the studied rooms, which enhances the importance of detailing the study of children's short and long-term exposure to this indoor air pollutant. While CO, NO2 and O3 never exceeded the national and international reference values for IAQ and health protection, exceedances were found for formaldehyde and VOC. For this reason, a health risk assessment approach could be interesting for future research to assess children's health risks of exposure to formaldehyde and to VOC concentrations in nursery schools. Changing cleaning schedules and materials emitting formaldehyde, and more efficient ventilation while using products emitting VOC, with the correct amount and distribution of fresh air, would decrease children's exposure. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Environmental impact of pyrolysis of mixed WEEE plastics part 2: Life cycle assessment.

    Science.gov (United States)

    Alston, Sue M; Arnold, J Cris

    2011-11-01

    Waste electrical and electronic equipment (WEEE) contains up to 25% plastics. Extraction of higher quality fractions for recycling leaves a mix of plastic types contaminated with other materials, requiring the least environmentally harmful disposal route. Data from trials of pyrolysis, described in part 1 of this paper set, were used in a life cycle assessment of the treatment of WEEE plastics. Various levels of recycling of the sorted fraction were considered, and pyrolysis was compared with incineration (with energy recovery) and landfill for disposal of the remainder. Increased recycling gave reduced environmental impact in almost all categories considered, although inefficient recycling decreased that benefit. Significant differences between pyrolysis, incineration and landfill were seen in climate change impacts, carbon sent to landfill, resources saved, and radiation. There was no overall "best" option. Landfill had the least short-term impact on climate change so could be a temporary means of sequestering carbon. Incineration left almost no carbon to landfill, but produced the most greenhouse gases. Pyrolysis or incineration saved most resources, with the balance depending on the source of electricity replaced by incineration. Pyrolysis emerged as a strong compromise candidate since the gases and oils produced could be used as fuels and so provided significant resource saving without high impact on climate change or landfill space.

  11. DETERMINING UNDISTURBED GROUND TEMPERATURE AS PART OF SHALLOW GEOTHERMAL RESOURCES ASSESSMENT

    Directory of Open Access Journals (Sweden)

    Tomislav Kurevija

    2010-12-01

    Full Text Available The undisturbed ground temperature is one of the key thermogeological parameters for the assessment and utilization of shallow geothermal resources. Geothermal energy is the type of energy which is stored in the ground where solar radiation has no effect. The depth at which the undisturbed ground temperature occurs, independent of seasonal changes in the surface air temperature, is functionally determined by climate parameters and thermogeological properties. In deeper layers, the increase of ground temperature depends solely on geothermal gradient. Determining accurate values of undisturbed ground temperature and depth of occurrence is crucial for the correct sizing of a borehole heat exchanger as part of the ground-source heat pump system, which is considered the most efficient technology for utilising shallow geothermal resources. The purpose of this paper is to define three specific temperature regions, based on the measured ground temperature data collected from the main meteorological stations in Croatia. The three regions are: Northern Croatia, Adriatic region, and the regions of Lika and Gorski Kotar.

  12. Phytochemical analysis, antibacterial, and antifungal assessment of aerial parts of Polygonatum verticillatum.

    Science.gov (United States)

    Khan, Haroon; Saeed, Muhammad; Muhammad, Naveed; Perviz, Samreen

    2016-05-01

    The current study was designed to assess the phytochemical profile, antibacterial, and antifungal activities of the crude methanol extract of the aerial parts of Polygonatum verticillatum (PA) and its various subsequent solvent fractions using agar well diffusion, agar tube dilution, and microdilution methods. Phytochemical analysis showed positive for different chemical groups and also contained marked quantity of saponin and flavonoid contents. Significant antibacterial activity was observed against various tested pathogenic bacteria. The only susceptible Gram-positive bacterium was Bacillus subtilis and their minimum inhibitory concentrations (MICs) measured ranged from 11-50 µg/ml. The sensitive Gram-negative bacteria were Salmonella typhi and Shigella flexeneri The estimated MICs were in the range of 2-7 µg/ml and 8-50 µg/ml for S. typhi and S. flexeneri, respectively. However, the antifungal activity of the plant was limited to Microsporum canis and their MICs ranged from 60 to 250 µg/ml. Our study confirmed significant antibacterial potential of the plant and substantiated its folk use in dysentery and pyrexia of multiple origins. © The Author(s) 2013.

  13. Economic Assessment of Supercritical CO2 Extraction of Waxes as Part of a Maize Stover Biorefinery

    Directory of Open Access Journals (Sweden)

    Thomas M. Attard

    2015-07-01

    Full Text Available To date limited work has focused on assessing the economic viability of scCO2 extraction to obtain waxes as part of a biorefinery. This work estimates the economic costs for wax extraction from maize stover. The cost of manufacture (COM for maize stover wax extraction was found to be €88.89 per kg of wax, with the fixed capital investment (FCI and utility costs (CUT contributing significantly to the COM. However, this value is based solely on scCO2 extraction of waxes and does not take into account the downstream processing of the biomass following extraction. The cost of extracting wax from maize stover can be reduced by utilizing pelletized leaves and combusting the residual biomass to generate electricity. This would lead to an overall cost of €10.87 per kg of wax (based on 27% combustion efficiency for electricity generation and €4.56 per kg of wax (based on 43% combustion efficiency for electricity generation. A sensitivity analysis study showed that utility costs (cost of electricity had the greatest effect on the COM.

  14. Economic Assessment of Supercritical CO2 Extraction of Waxes as Part of a Maize Stover Biorefinery.

    Science.gov (United States)

    Attard, Thomas M; McElroy, Con Robert; Hunt, Andrew J

    2015-07-31

    To date limited work has focused on assessing the economic viability of scCO2 extraction to obtain waxes as part of a biorefinery. This work estimates the economic costs for wax extraction from maize stover. The cost of manufacture (COM) for maize stover wax extraction was found to be € 88.89 per kg of wax, with the fixed capital investment (FCI) and utility costs (CUT) contributing significantly to the COM. However, this value is based solely on scCO2 extraction of waxes and does not take into account the downstream processing of the biomass following extraction. The cost of extracting wax from maize stover can be reduced by utilizing pelletized leaves and combusting the residual biomass to generate electricity. This would lead to an overall cost of € 10.87 per kg of wax (based on 27% combustion efficiency for electricity generation) and €4.56 per kg of wax (based on 43% combustion efficiency for electricity generation). A sensitivity analysis study showed that utility costs (cost of electricity) had the greatest effect on the COM.

  15. Survey and Assessment of Models or Decision Rules Determining Spare Part Levels for Navy Electronics Equipments.

    Science.gov (United States)

    1979-09-07

    application to parts with no usage history Literature Source: Naval Research Logistics Quarterly, Vol. 17, Dec. 1970, S. E. Haber and R. Sitgreaves...Estimating S. E. Haber and Expected Usage of Repair Parts R. Sitgreaves with Application to Parts with no History 15 The Allowance Parts List 18 Reliability...Cost Guy Black and Frank Proschan 30 Spares and System Availability J. Vanden Bosch A-i Title No. Literature Source Author 31 A Monte Carlo Aoproach to

  16. Ultrasound assessment on selected peripheral nerve pathologies. Part I: Entrapment neuropathies of the upper limb – excluding carpal tunnel syndrome

    Directory of Open Access Journals (Sweden)

    Berta Kowalska

    2012-09-01

    Full Text Available Ultrasound (US is one of the methods for imaging entrapment neuropathies, post-trau‑ matic changes to nerves, nerve tumors and postoperative complications to nerves. This type of examination is becoming more and more popular, not only for economic reasons, but also due to its value in making accurate diagnosis. It provides a very precise assess‑ ment of peripheral nerve trunk pathology – both in terms of morphology and localization. During examination there are several options available to the specialist: the making of a dynamic assessment, observation of pain radiation through the application of precise palpation and the comparison of resultant images with the contra lateral limb. Entrap‑ ment neuropathies of the upper limb are discussed in this study, with the omission of median nerve neuropathy at the level of the carpal canal, as extensive literature on this subject exists. The following pathologies are presented: pronator teres muscle syndrome, anterior interosseus nerve neuropathy, ulnar nerve groove syndrome and cubital tun‑ nel syndrome, Guyon’s canal syndrome, radial nerve neuropathy, posterior interosseous nerve neuropathy, Wartenberg’s disease, suprascapular nerve neuropathy and thoracic outlet syndrome. Peripheral nerve examination technique has been presented in previous articles presenting information about peripheral nerve anatomy [Journal of Ultrasonog‑ raphy 2012; 12 (49: 120–163 – Normal and sonographic anatomy of selected peripheral nerves. Part I: Sonohistology and general principles of examination, following the exam‑ ple of the median nerve; Part II: Peripheral nerves of the upper limb; Part III: Peripheral nerves of the lower limb]. In this article potential compression sites of particular nerves are discussed, taking into account pathomechanisms of damage, including predisposing anatomical variants (accessory muscles. The parameters of ultrasound assessment have been established – echogenicity and

  17. Assessing End-Of-Supply Risk of Spare Parts Using the Proportional Hazard Model

    NARCIS (Netherlands)

    X. Li (Xishu); R. Dekker (Rommert); C. Heij (Christiaan); M. Hekimoğlu (Mustafa)

    2016-01-01

    textabstractOperators of long field-life systems like airplanes are faced with hazards in the supply of spare parts. If the original manufacturers or suppliers of parts end their supply, this may have large impacts on operating costs of firms needing these parts. Existing end-of-supply evaluation

  18. HPLC fingerprinting approach for raw material assessment and unit operation tracking for IVIG production from Cohn I+II+III fraction.

    Science.gov (United States)

    Peljhan, Sebastijan; Jakop, Tina; Šček, Dunja; Skvarča, Vid; Goričar, Blaž; Žabar, Romina; Mencin, Nina

    2017-11-01

    The plasma-derived IgG used either for diagnostic purpose or intravenous application (in form of IVIG) in various medical therapies is certainly gaining more and more attention on annual basis. Different manufacturing processes are used to isolate immunoglobulins from human plasma. However, a quest for alternative paths in IgG isolation not only requires development of the most efficient isolation process, but also a rapid and reliable analytics to track the purification. Fast and reliable fingerprint-based method for characterization of IgG prepared from Cohn I+II+III paste is presented in this paper. The fingerprint method bases on partial separation of proteins in linear gradient on CIMac™ quaternary amine, strong anion exchange group (QA) 0.1 mL column. Partial separation of proteins does not allow simple quantitative analysis of the samples during the IgG isolation from Cohn I+II+III fraction paste, but very accurate qualitative information about the composition of the sample can be obtained in less than 5 min. From the differences in the chromatograms of various samples, the ratio between IgG and impurities in each sample can be easily assessed. The method is suitable for input material control, in-line monitoring of the downstream processing, final control of the products, as well as in stability studies and enables taking fast and accurate decisions during fractionation process. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Shaping the breast in aesthetic and reconstructive breast surgery: an easy three-step principle. Part III--reconstruction following breast conservative treatment.

    Science.gov (United States)

    Blondeel, Phillip N; Hijjawi, John; Depypere, Herman; Roche, Nathalie; Van Landuyt, Koenraad

    2009-07-01

    Of the relatively few studies that exist regarding the cosmetic satisfaction of patients following breast conservation therapy, several indicate significant dissatisfaction in many patients. Breast conservation often results in some of the most challenging and complex reconstructive problems. Indeed, even defining the problem or analyzing the defect can be difficult for the junior surgeon. For the more seasoned reconstructive surgeon, analyzing the problem and applying solutions may be less difficult, but clearly communicating the defects typically seen after an aggressive lumpectomy and radiotherapy can be difficult, especially with trainees or junior surgeons. The goal of this article, the third in a four-part series, is to provide a template for the analysis and surgical reconstruction of defects resulting from breast conservation therapy utilizing a systematic three-step method. Part I of this series described the three main anatomical features of the breast--the footprint, the conus of the breast, and the skin envelope--and how they interact. By systematically analyzing the breast with this three-step method, a "problem list" based in specific anatomic traits of the breast can be generated, allowing the surgeon to then generate an appropriate surgical plan for reconstruction. Surgical approaches based on the percentage of breast parenchyma resected are suggested, with a focus on glandular rearrangement, breast reduction techniques, and locoregional flaps. The three-step method of breast analysis, evaluating the anatomical deformation of the breast footprint, conus, and skin envelope, remains the fundamental "fall-back" principle of this approach.

  20. A Fully Nonmetallic Gas Turbine Engine Enabled by Additive Manufacturing of Ceramic Composites. Part III; Additive Manufacturing and Characterization of Ceramic Composites

    Science.gov (United States)

    Halbig, Michael C.; Grady, Joseph E.; Singh, Mrityunjay; Ramsey, Jack; Patterson, Clark; Santelle, Tom

    2015-01-01

    This publication is the third part of a three part report of the project entitled "A Fully Nonmetallic Gas Turbine Engine Enabled by Additive Manufacturing" funded by NASA Aeronautics Research Institute (NARI). The objective of this project was to conduct additive manufacturing to produce ceramic matrix composite materials and aircraft engine components by the binder jet process. Different SiC powders with median sizes ranging from 9.3 to 53.0 microns were investigated solely and in powder blends in order to maximize powder packing. Various infiltration approaches were investigated to include polycarbosilane (SMP-10), phenolic, and liquid silicon. Single infiltrations of SMP-10 and phenolic only slightly filled in the interior. When the SMP-10 was loaded with sub-micron sized SiC powders, the infiltrant gave a much better result of filling in the interior. Silicon carbide fibers were added to the powder bed to make ceramic matrix composite materials. Microscopy showed that the fibers were well distributed with no preferred orientation on the horizontal plane and fibers in the vertical plane were at angles as much as 45deg. Secondary infiltration steps were necessary to further densify the material. Two to three extra infiltration steps of SMP-10 increased the density by 0.20 to 0.55 g/cc. However, the highest densities achieved were 2.10 to 2.15 g/cc. Mechanical tests consisting of 4 point bend tests were conducted. Samples from the two CMC panels had higher strengths and strains to failure than the samples from the two nonfiber reinforced panels. The highest strengths were from Set N with 65 vol% fiber loading which had an average strength of 66 MPa. Analysis of the fracture surfaces did not reveal pullout of the reinforcing fibers. Blunt fiber failure suggested that there was not composite behavior. The binder jet additive manufacturing method was used to also demonstrate the fabrication of turbine engine vane components of two different designs and sizes. The

  1. Assessing compliance of cardiologists with the national cholesterol education program (NCEP III guidelines in an ambulatory care setting

    Directory of Open Access Journals (Sweden)

    Salihu Hamisu M

    2004-05-01

    Full Text Available Abstract Introduction The NCEP III -ATP guidelines provide clear clinical directives for lipid management especially statins therapy in appropriate patient groups. Compliance of primary care physicians with these guidelines especially in ambulatory care settings has been shown to be poor. The compliance of cardiologist to these guidelines is less documented. Methods A retrospective chart review of 386 patients managed in a large urban cardiology practice was undertaken. Patients with documented contraindications to use of statins were excluded from the study. Only patients with two or more years of follow-up in the practice were included. Demographic variables and medical history including CAD or its equivalent and its major risk factors were identified. The proportion of patients on statins and adequacy of statins therapy were recorded. The lipid profiles of all patients were also analyzed. Results Fifteen patients with documented contraindications to statins therapy including persistent/severe LFT abnormalities, allergies, and gastrointestinal intolerance were excluded. A total of 371 patients were included in the analysis. The mean age for patients in the study was 65 years (range: 42–84. 236 (64% were males while 141 (36% were females. 161 (43% patients were on statins while 210 (57% weren't. 88 (62% of females were on stain compared to 116 (49% of males (p = 0.001. 68% of patients below the age of 50 yrs were not on statins compared with 55% of those greater than 50 yrs (p = 0.01. 38% of patients on statins therapy had sub-optimal lipid profile despite greater than two years of therapy. No statistically significant differences in race and use of satins were noted. Conclusion This study demonstrates a higher than expected prevalence of sub-optimal management of dyslipidemia among patients with established coronary heart disease without contraindications to statins managed by cardiologists. Cardiology and primary care practices require

  2. The model SIRANE for atmospheric urban pollutant dispersion. PART III: Validation against NO2 yearly concentration measurements in a large urban agglomeration

    Science.gov (United States)

    Soulhac, L.; Nguyen, C. V.; Volta, P.; Salizzoni, P.

    2017-10-01

    We present a validation study of an updated version of the SIRANE model, whose results have been systematically compared to concentrations of nitrogen dioxide collected over the whole urban agglomeration of Lyon. We model atmospheric dispersion of nitrogen oxides emitted by road traffic, industries and domestic heating. The meteorological wind field is computed by a pre-processor using data collected at a ground level monitoring station. Model results are compared with hourly concentrations measured at 15 monitoring stations over the whole year (2008). Further 75 passive diffusion samplers were used during 3 periods of 2 weeks to get a detailed spatial distribution over the west part of the city. An analysis of the model results depending on the variability of the meteorological input allows us to identify the causes for peculiar bad performances of the model and to identify possible improvements of the parameterisations implemented in it.

  3. Semiconducting III-V compounds

    CERN Document Server

    Hilsum, C; Henisch, Heinz R

    1961-01-01

    Semiconducting III-V Compounds deals with the properties of III-V compounds as a family of semiconducting crystals and relates these compounds to the monatomic semiconductors silicon and germanium. Emphasis is placed on physical processes that are peculiar to III-V compounds, particularly those that combine boron, aluminum, gallium, and indium with phosphorus, arsenic, and antimony (for example, indium antimonide, indium arsenide, gallium antimonide, and gallium arsenide).Comprised of eight chapters, this book begins with an assessment of the crystal structure and binding of III-V compounds, f

  4. Image quality assessment in digital mammography: part I. Technical characterization of the systems

    Science.gov (United States)

    Marshall, N. W.; Monnin, P.; Bosmans, H.; Bochud, F. O.; Verdun, F. R.

    2011-07-01

    In many European countries, image quality for digital x-ray systems used in screening mammography is currently specified using a threshold-detail detectability method. This is a two-part study that proposes an alternative method based on calculated detectability for a model observer: the first part of the work presents a characterization of the systems. Eleven digital mammography systems were included in the study; four computed radiography (CR) systems, and a group of seven digital radiography (DR) detectors, composed of three amorphous selenium-based detectors, three caesium iodide scintillator systems and a silicon wafer-based photon counting system. The technical parameters assessed included the system response curve, detector uniformity error, pre-sampling modulation transfer function (MTF), normalized noise power spectrum (NNPS) and detective quantum efficiency (DQE). Approximate quantum noise limited exposure range was examined using a separation of noise sources based upon standard deviation. Noise separation showed that electronic noise was the dominant noise at low detector air kerma for three systems; the remaining systems showed quantum noise limited behaviour between 12.5 and 380 µGy. Greater variation in detector MTF was found for the DR group compared to the CR systems; MTF at 5 mm-1 varied from 0.08 to 0.23 for the CR detectors against a range of 0.16-0.64 for the DR units. The needle CR detector had a higher MTF, lower NNPS and higher DQE at 5 mm-1 than the powder CR phosphors. DQE at 5 mm-1 ranged from 0.02 to 0.20 for the CR systems, while DQE at 5 mm-1 for the DR group ranged from 0.04 to 0.41, indicating higher DQE for the DR detectors and needle CR system than for the powder CR phosphor systems. The technical evaluation section of the study showed that the digital mammography systems were well set up and exhibiting typical performance for the detector technology employed in the respective systems.

  5. Microelectronic Status Analysis and Secondary Part Procureability Assessment of the THAAD Weapon System

    National Research Council Canada - National Science Library

    Maddux, Gary

    1999-01-01

    AMCOM required engineering support in performing microelectronic technology and availability assessments for several hundred items and in assessing the impact of nonavailability on the THAAD weapon system...

  6. Stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit in Jaworzno III Power Plant - Power Plant II

    Science.gov (United States)

    Karpiński, Marcin; Kmiecik, Ewa

    2017-11-01

    In Poland, electricity is still produced mainly in conventional power plants where fuel and water are materials necessary to generate the electricity. Even in modern power plants operating according to the principles of the sustainable development, this involves a high intake of water and considerable production of wastewater. This, in turn, necessi-tates the application of some technological solutions aimed at limiting the negative impact on the environment. The Jaworzno III Power Plant - Power Plant II is located in Jaworzno, Silesian Province, Poland. In order to minimise the negative impact on the surface water, the plant replenishes the cooling circuit with the mining water obtained from the closed-down Jan Kanty mine. The paper presents a stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit based on the data from 2007-2017.

  7. Stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit in Jaworzno III Power Plant – Power Plant II

    Directory of Open Access Journals (Sweden)

    Karpiński Marcin

    2017-01-01

    Full Text Available In Poland, electricity is still produced mainly in conventional power plants where fuel and water are materials necessary to generate the electricity. Even in modern power plants operating according to the principles of the sustainable development, this involves a high intake of water and considerable production of wastewater. This, in turn, necessi-tates the application of some technological solutions aimed at limiting the negative impact on the environment. The Jaworzno III Power Plant – Power Plant II is located in Jaworzno, Silesian Province, Poland. In order to minimise the negative impact on the surface water, the plant replenishes the cooling circuit with the mining water obtained from the closed-down Jan Kanty mine. The paper presents a stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit based on the data from 2007–2017.

  8. Soil burdens of persistent organic pollutants--their levels, fate and risks Part III. Quantification of the soil burdens and related health risks in the Czech Republic.

    Science.gov (United States)

    Cupr, Pavel; Bartos, Tomás; Sánka, Milan; Klánová, Jana; Mikes, Ondrej; Holoubek, Ivan

    2010-01-01

    A total number of 471 soil samples collected during the period of 1996-2006 from the agricultural and forest areas of the Czech Republic were analyzed for their content of persistent organic pollutants (POPs). Spatial variability of the POP concentrations was assessed using an IDW spatial GIS model analysis. For every grid of the network, resulting modeled levels of contamination allowed for estimation of the total burden of POPs in soils. Potential risks associated with contaminated soils were assessed as well. Database of the old ecological burdens counting 3061 sampling sites was used to adjust the model and incorporate the risks of heavily contaminated sites. The high levels of health risks were only found at less than 1% of the area of interest. The IDW modeling proved to be a useful tool for screening of the health risks in the large areas with scarce monitoring data. Presented approach can be applied in the risk management, to support an efficient targeting of the risk reduction measures, or to improve a design of the national monitoring.

  9. The Impact of Massage Therapy on Function in Pain Populations—A Systematic Review and Meta-Analysis of Randomized Controlled Trials: Part III, Surgical Pain Populations

    Science.gov (United States)

    Crawford, Cindy; Paat, Charmagne F.; Price, Ashley; Xenakis, Lea; Zhang, Weimin

    2016-01-01

    Objective. Pain is multi-dimensional and may be better addressed through a holistic, biopsychosocial approach. Massage therapy is commonly practiced among patients seeking pain management; however, its efficacy is unclear. This systematic review and meta-analysis is the first to rigorously assess the quality of the evidence for massage therapy’s efficacy in treating pain, function-related, and health-related quality of life outcomes in surgical pain populations. Methods. Key databases were searched from inception through February 2014. Eligible randomized controlled trials were assessed for methodological quality using SIGN 50 Checklist. Meta-analysis was applied at the outcome level. A professionally diverse steering committee interpreted the results to develop recommendations. Results. Twelve high quality and four low quality studies were included in the review. Results indicate massage therapy is effective for treating pain [standardized mean difference (SMD) = −0.79] and anxiety (SMD = −0.57) compared to active comparators. Conclusion. Based on the available evidence, weak recommendations are suggested for massage therapy, compared to active comparators for reducing pain intensity/severity and anxiety in patients undergoing surgical procedures. This review also discusses massage therapy safety, challenges within this research field, how to address identified research gaps, and next steps for future research. PMID:27165970

  10. Investigation into the Noise Associated with Airbag Deployment: Part III – Sound Pressure Level and Auditory Risk as a Function of Inflatable Device

    Science.gov (United States)

    Banglmaier, R.F.; Rouhana, S.W.

    2003-01-01

    Several criteria for assessing noise-induced hearing loss from automotive inflatable devices, such as airbags, were proposed in the past. However, their development was based on epidemiological studies of steady state noise and not impulsive noise. More recently, the US Army Research Laboratory (ARL) developed and validated a mathematical model of the ear, which may be used to assess noise induced hearing loss from impulsive noise sources. Previous studies have contributed to understanding the effects of impulse noise on occupants, but were performed on first generation frontal airbags and did not provide information on airbag and occupant safety systems in today’s fleet of vehicles. This study presents the results of a parametric investigation of current inflatable devices across a variety of vehicles and considers the size and seating location of the occupant in vehicles of varying volume. In addition, the study considers advanced airbag technologies such as dual stage frontal airbags, side airbags, inflatable curtains, and seat belt pretensioners. PMID:12941213

  11. Benefits of Cervical Cancer Screening by Liquid-Based Cytology as Part of Routine Antenatal Assessment.

    Science.gov (United States)

    Parkpinyo, Nichamon; Inthasorn, Perapong; Laiwejpithaya, Somsak; Punnarat, Tippawan

    2016-01-01

    To determine the prevalence of abnormal cervical cytology, as diagnosed using a liquid-based cytology technique, in pregnant women attending the Antenatal Care (ANC) clinic at Siriraj Hospital. This cross-sectional study included 655 first-visit pregnant women who attended ANC clinic at Siriraj Hospital during June to November 2015 study period. After receiving routine antenatal care, cervical cytology screening was performed with the Siriraj liquid-based cytology technique. All specimens were reviewed by a certi ed cytopathologist using Bethesda System 2001 criteria. Patients with abnormal PAP results characterized as epithelial cell abnormalities were referred to a gynecologic oncologist for further management according to ASCCP Guidelines 2012. Mean age of participants was 28.9±6.2 years. Prevalence of abnormal cervical cytology was 3.4% (95% CI: 2.0-4.7). Among this group, there were ASC-US, ASC-H, LSIL, HSIL for 12(1.8%), 2(0.3%), 7(1.1%) and 1(0.2%), respectively. In 633 specimens of the normal group, infection was identified in 158 specimens (24.1%) which were caused by Candida spp. and Trichomonas vaginalis. Regarding patient perception about the importance of cervical cancer screening, although most women perceived screening to be important, 54% of participants had never been screened for cervical cancer. Rate of loss to follow-up in the postpartum period was as high as 41.8%. Prevalence of abnormal cervical cytology in pregnant women attending the ANC clinic at Siriraj Hospital was 3.4%. Inclusion of cervical cancer screening as part of antenatal assessment can help to identify precancerous lesions or cervical cancers in patients who might otherwise not be screened, thereby facilitating early treatment and improved patient outcomes.

  12. Assessing the Relevancy of "Citation Classics" in Neurosurgery. Part II: Foundational Papers in Neurosurgery.

    Science.gov (United States)

    Bohl, Michael A; Turner, Jay D; Little, Andrew S; Nakaji, Peter; Ponce, Francisco A

    2017-08-01

    The second part of this study reanalyzes Ponce and Lozano's (2010) list of classics to create a new list of "foundational" articles in neurosurgery. Ponce and Lozano (2010) previously published a list of 106 neurosurgery classics, as defined by Garfield and his 400 citation criterion. We used the Web of Science citation reports to create graphs for each study showing the total citations it received as a function of time. Each graph was subjectively analyzed independently and scored as "foundational" or "classic only," based on whether the trend of citations received per year was uptrending, neutral, or downtrending. Of the 101 evaluated classics, 53 qualified as foundational. Over half of these studies were published in Journal of Neurosurgery (13), New England Journal of Medicine (12), or Lancet (5). Grading systems, randomized trials, and prospective studies were most likely to achieve foundational status. Only 30% of functional and 17% of endovascular classics qualified as foundational (compared with 100% of spine classics), suggesting that these fields are rapidly changing or less mature subspecialties still developing a foundational literature base. By assessing citation counts as a function of time, we are able to differentiate classic neurosurgical studies that are critical to modern-day practice from those that are primarily of historic interest. Given the exponential growth of literature in our field, analyses such as these will become increasingly important to both trainees and senior neurosurgeons who strive to educate themselves on the data that drive modern-day clinical decision making. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. TLC-MS versus TLC-LC-MS fingerprints of herbal extracts. Part III. Application of the reversed-phase liquid chromatography systems with C18 stationary phase.

    Science.gov (United States)

    Sajewicz, Mieczysław; Staszek, Dorota; Natic, Maja; Waksmundzka-Hajnos, Monika; Kowalska, Teresa

    2011-08-01

    In the previous paper from this series, we proposed mass spectrometric fingerprinting of complex botanical samples upon the examples of the pharmacologically important phenolic acids and flavonoids selectively extracted from Salvia lavandulifolia. In this study, we explore fingerprinting efficiency with a novel two-dimensional analytical system composed of the reversed-phase thin-layer chromatography and the reversed-phase high performance liquid chromatography with mass spectrometric detection (2D RP-TLC-RP-LC-MS). We also compare its efficiency with that of the one-dimensional analytical system (the reversed-phase thin-layer chromatography with mass spectrometric detection; 1D RP-TLC-MS). As our present study is basically focused on the method development, we considered it as justified to carry out our comparison with the phenolic acid extracts selectively derived from the Salvia lavandulifolia species, similar as it was done in Part II from this series. Upon the results obtained, it was established that the 1D RP-TLC-MS mode and the 2D RP-TLC-RP-LC-MS mode can be applied to fingerprinting of herbal extracts, and that the 2D RP-TLC-RP-LC mode can provide a more abundant information than that originating from the 1D RP-TLC mode.

  14. Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical phase I/II study

    Directory of Open Access Journals (Sweden)

    Freihorst Joachim

    2007-08-01

    Full Text Available Abstract Background Vaccination against Pseudomonas aeruginosa is a desirable albeit challenging strategy for prevention of airway infection in patients with cystic fibrosis. We assessed the immunogenicity of a nasal vaccine based on the outer membrane proteins F and I from Pseudomonas aeruginosa in the lower airways in a phase I/II clinical trial. Methods N = 12 healthy volunteers received 2 nasal vaccinations with an OprF-OprI gel as a primary and a systemic (n = 6 or a nasal booster vaccination (n = 6. Antibodies were assessed in induced sputum (IS, bronchoalveolar lavage (BAL, and in serum. Results OprF-OprI-specific IgG and IgA antibodies were found in both BAL and IS at comparable rates, but differed in the predominant isotype. IgA antibodies in IS did not correlate to the respective serum levels. Pulmonary antibodies were detectable in all vaccinees even 1 year after the vaccination. The systemic booster group had higher IgG levels in serum. However, the nasal booster group had the better long-term response with bronchial antibodies of both isotypes. Conclusion The nasal OprF-OprI-vaccine induces a lasting antibody response at both, systemic and airway mucosal site. IS is a feasible method to non-invasively assess bronchial antibodies. A further optimization of the vaccination schedule is warranted.

  15. Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a Phase III randomized controlled trial.

    Science.gov (United States)

    Nichols, Kelly K; Holland, Edward; Toyos, Melissa M; Peace, James H; Majmudar, Parag; Raychaudhuri, Aparna; Hamdani, Mohamed; Roy, Monica; Shojaei, Amir

    2018-01-01

    To evaluate ocular comfort of lifitegrast ophthalmic solution 5.0% among patients with dry eye disease (DED) in the OPUS-3 trial. OPUS-3 was a multicenter, randomized, double-masked, placebo-controlled study. Adults with DED and recent artificial tear use were randomized 1:1 (lifitegrast:placebo) to ophthalmic drops twice daily for 84 days. On days 0 (baseline), 14, 42, and 84, drop comfort score (scale, 0-10; 0 = very comfortable, 10 = very uncomfortable) was measured at 0, 1, 2, and 3 minutes postinstillation. If the score was >3 at 3 minutes, assessment was repeated at 5, 10, and 15 minutes until score ≤3. Ocular treatment-emergent adverse events (TEAEs) were assessed. Overall, 711 participants were randomized (n=357 received lifitegrast; n=354 received placebo). Drop comfort scores for lifitegrast-treated participants improved within 3 minutes of instillation (mean scores on day 84 for both study and fellow eyes: instillation: lifitegrast, 3.4, placebo, 1.0; 3 minutes: lifitegrast, 1.5, placebo, 0.7). The majority (64%-66%) of participants had scores 3 at 3 minutes, the mean score in the lifitegrast group was similar to or better than that in the placebo group at 5, 10, or 15 minutes postinstillation. Lifitegrast appeared to be well tolerated, with ocular TEAEs rarely leading to discontinuation. In OPUS-3, lifitegrast appeared to be well tolerated and drop comfort scores approached placebo levels by 3 minutes postinstillation.

  16. A lean methane premixed laminar flame doped with components of diesel fuel part III: Indane and comparison between n-butylbenzene, n-propylcyclohexane and indane

    Energy Technology Data Exchange (ETDEWEB)

    Pousse, E.; Tian, Z.Y.; Glaude, P.A.; Fournet, R.; Battin-Leclerc, F. [Laboratoire des Reactions et de Genie des Procedes, CNRS, Nancy Universite, 1 rue Grandville, BP 20451, 54001 NANCY Cedex (France)

    2010-07-15

    To better understand the chemistry of the combustion of components of diesel fuel, the structure of a laminar lean premixed methane flame doped with indane has been investigated. The inlet gases contained 7.1% (molar) of methane, 36.8% of oxygen and 0.9% of indane corresponding to an equivalence ratio of 0.67 and a ratio C{sub 10}H{sub 14}/CH{sub 4} of 12.8%. The flame has been stabilized on a burner at a pressure of 6.7 kPa (50 Torr) using argon as diluent, with a gas velocity at the burner of 49.1 cm s{sup -1} at 333 K. Quantified species included the usual methane C{sub 0}-C{sub 2} combustion products, but also 16 C{sub 3}-C{sub 5} non-aromatic hydrocarbons, 6 C{sub 1}-C{sub 3} non-aromatic oxygenated compounds, as well as 22 aromatic products, namely benzene, toluene, xylenes, phenylacetylene, ethylbenzene, styrene, propenylbenzene, allylbenzene, n-propylbenzene, methylstyrenes, ethyltoluenes, trimethylbenzenes, n-butylbenzene, dimethylethylbenzene, indene, methylindenes, methylindane, benzocyclobutene, naphthalene, phenol, benzaldehyde, and benzofuran. A new mechanism for the oxidation of indane was proposed whose predictions were in satisfactory agreement with measured species profiles in both flames and jet-stirred reactor experiments. The main reaction pathways of consumption of indane have been derived from flow rate analyses in the two types of reactors. A comparison of the effect of the addition of three components of diesel fuel, namely indane, n-butylbenzene and n-propylcyclohexane (parts I and II of this series of paper), on the structure of a laminar lean premixed methane flame is also presented. (author)

  17. Quality control and process capability assessment for injection-moulded micro mechanical parts

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard

    2013-01-01

    Quality control of micro components is an increasing challenge. Smaller mechanical parts are characterized by smaller tolerance to be verified. This paper focuses on the dimensional verification of micro injection-moulded components selected from an industrial application. These parts are measure...

  18. [Evidence based medicine (EBM) in health care system and treatment of individual patient. Part iii. Teaching of epidemiological methodology and statistics].

    Science.gov (United States)

    Borkowski, Włodzimierz

    2009-01-01

    The question arises--what role the doctor will meet in the web society. Is it going to be a creative person in the assessment of knowledge and application at the bedside of the patient, disciplined executor of he clinical guidelines, or a loyal client of pharmaceutical companies. Medical theories are usually at the high degree of complexity, so the evaluation of the validity of the research questions, the adequacy ot models, appraisal of clinical trials, and the use of statistical analysis requires new teaching. Teaching epidemiology and statistics for EBM is designed to prepare doctors for applyinig scientific advances in clinical practice, skills in appraisal and use of the publicated results. Effects of teaching on courses organised by CMKP shows that the barrier in learning of statistical concepts are caused by defective curricula and their faulty implementation, and not by narrow perception of physicians. According to the author, such teaching should also be applied during graduated medical studies, as optional. After co-ordination with the physiology, genetics, biochemistry, informatics EBM oriented teaching would be particularly attractive for students who have a view on the work of research and research careers. Bearing in mind the time needed for implementation, it is urgent need to start this work as soon as possible.

  19. Sleep improvement for restless legs syndrome patients. Part III: effect of treatment assignment belief on sleep improvement in restless legs syndrome patients. A mediation analysis

    Directory of Open Access Journals (Sweden)

    Burbank F

    2013-04-01

    Full Text Available Fred Burbank Director, Salt Creek International Women's Health Foundation, San Clemente, CA, USA Purpose: Two parallel-design, randomized, sham-controlled clinical trials were conducted to study the safety and efficacy of vibratory stimulation (VS on restless legs syndrome (RLS patients (Part I of this series of articles. Pooled data from the two studies was retroactively analyzed to compare the relative effects of actual pad assignment with therapeutic pad assignment belief on sleep improvement for patients with RLS. Patients and methods: One hundred fifty-eight patients with at least moderately severe RLS, as measured by a score of 15 points or greater on the International Restless Legs Syndrome Study Group rating scale (IRLS, were enrolled in the study. Patients were randomly assigned to treatment (patient-controlled vibration or sham (patient-controlled sound or light-emitting pads. Patients and clinicians were blinded to pad assignment. The pad was placed under the patient's legs while in bed at night and activated during an RLS episode. Improvements in Medical Outcomes Study Sleep Problems Index II (MOS-II scores from baseline to week 4 were examined as a function of pad assignment (independent variable and therapeutic pad assignment belief held by each patient (mediator variable through mediation analysis. Results: Therapeutic pad assignment belief influenced change in MOS-II scores more than actual pad assignment. Patients who believed they had been assigned a therapeutic pad had substantially greater sleep improvement than those who concluded the opposite. When a patient believed that a therapeutic pad had been assigned, sleep improvement was comparable in magnitude, independent of the type of pad assigned (vibrating or sham. Patients assigned vibrating pads believed that they had been assigned a therapeutic pad 2.6 times more frequently than patients assigned sham pads. Consequently, vibrating pads were more efficient at improving

  20. AMEE Guide No. 14. Outcome-Based Education: Part 3--Assessment in Outcome-Based Education.

    Science.gov (United States)

    Ben-David, Miriam Friedman

    1999-01-01

    Discusses the role of performance assessment in outcome-based education. Compares the relationship and interplay between the two related paradigms and presents guidelines of assessment programs in outcome-based education. (Author/CCM)

  1. Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a Phase III randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Nichols KK

    2018-01-01

    Full Text Available Kelly K Nichols,1 Edward Holland,2 Melissa M Toyos,3 James H Peace,4 Parag Majmudar,5 Aparna Raychaudhuri,6 Mohamed Hamdani,6 Monica Roy,6 Amir Shojaei6 1School of Optometry, University of Alabama at Birmingham, Birmingham, AL, 2Cincinnati Eye Institute, Edgewood, KY, 3Toyos Clinic, Nashville, TN, 4United Medical Research Institute, Inglewood, CA, 5Chicago Cornea Consultants, Ltd., Hoffman Estates, IL, 6Shire, Lexington, MA, USA Purpose: To evaluate ocular comfort of lifitegrast ophthalmic solution 5.0% among patients with dry eye disease (DED in the OPUS-3 trial. Methods: OPUS-3 was a multicenter, randomized, double-masked, placebo-controlled study. Adults with DED and recent artificial tear use were randomized 1:1 (lifitegrast:placebo to ophthalmic drops twice daily for 84 days. On days 0 (baseline, 14, 42, and 84, drop comfort score (scale, 0–10; 0 = very comfortable, 10 = very uncomfortable was measured at 0, 1, 2, and 3 minutes postinstillation. If the score was >3 at 3 minutes, assessment was repeated at 5, 10, and 15 minutes until score ≤3. Ocular treatment-emergent adverse events (TEAEs were assessed. Results: Overall, 711 participants were randomized (n=357 received lifitegrast; n=354 received placebo. Drop comfort scores for lifitegrast-treated participants improved within 3 minutes of instillation (mean scores on day 84 for both study and fellow eyes: instillation: lifitegrast, 3.4, placebo, 1.0; 3 minutes: lifitegrast, 1.5, placebo, 0.7. The majority (64%–66% of participants had scores <3 within 3 minutes postinstillation on days 14, 42, and 84. In participants with scores >3 at 3 minutes, the mean score in the lifitegrast group was similar to or better than that in the placebo group at 5, 10, or 15 minutes postinstillation. Lifitegrast appeared to be well tolerated, with ocular TEAEs rarely leading to discontinuation. Conclusion: In OPUS-3, lifitegrast appeared to be well tolerated and drop comfort scores approached placebo

  2. Music Education for Life: Music Assessment, Part 1--What and Why

    Science.gov (United States)

    Shuler, Scott C.

    2011-01-01

    Assessment is both essential and a potentially powerful positive force. Music teachers need to provide assessment evidence to survive in today's data-driven school environment. However, the more important reasons they must assess are to improve their professional effectiveness as teachers, to improve student learning, and to help them advocate for…

  3. Nutritional Status Assessment During the Phase IIA and Phase III Lunar/Mars Life Support Test Project

    Science.gov (United States)

    Smith, Scott M.; Block, Gladys; Davis-Street, Janis E.; DeKerlegand, Diane E.; Fanselow, Stephanie A.; Fesperman, J. Vernell; Gillman, Patricia L.; Nillen, Jeannie I.; Rice, Barbara L.; Smith, Myra D.

    2000-01-01

    Nutrition is a critical concern for extended-duration space missions (Smith and Lane, 1999). Loss of body weight is a primary consequence of altered nutrition, and is frequently observed during space flight (Smith and Lane; 1999). Other existing dietary concerns for space flight include excessive intakes of sodium and iron, and insufficient intakes of water and vitamin D (Smith and Lane, 1999). Furthermore, dependence on closed or semi-closed food systems increases the likelihood of inadequate intakes of key nutrients. This is a significant concern for extended-duration space missions. Space nutrition research often necessitates detailed recording of all food consumption. While this yields extremely accurate data, it requires considerable time and effort, and thus is not suitable for routine medical monitoring during space flight. To alleviate this problem, a food frequency questionnaire (FFQ) was designed to provide a quick and easy, yet reasonably accurate, method for crewmembers to provide dietary intake information to the ground. We report here a study which was designed to assess nutritional status before, during, and after the 60-d and 91-d chamber stays. An additional goal of the study was to validate a food frequency questionnaire designed specifically for use with space flight food systems.

  4. Effectiveness of water infrastructure for river flood management – Part 1: Flood hazard assessment using hydrological models in Bangladesh

    Directory of Open Access Journals (Sweden)

    M. A. Gusyev

    2015-06-01

    Full Text Available This study introduces a flood hazard assessment part of the global flood risk assessment (Part 2 conducted with a distributed hydrological Block-wise TOP (BTOP model and a GIS-based Flood Inundation Depth (FID model. In this study, the 20 km grid BTOP model was developed with globally available data on and applied for the Ganges, Brahmaputra and Meghna (GBM river basin. The BTOP model was calibrated with observed river discharges in Bangladesh and was applied for climate change impact assessment to produce flood discharges at each BTOP cell under present and future climates. For Bangladesh, the cumulative flood inundation maps were produced using the FID model with the BTOP simulated flood discharges and allowed us to consider levee effectiveness for reduction of flood inundation. For the climate change impacts, the flood hazard increased both in flood discharge and inundation area for the 50- and 100-year floods. From these preliminary results, the proposed methodology can partly overcome the limitation of the data unavailability and produces flood~maps that can be used for the nationwide flood risk assessment, which is presented in Part 2 of this study.

  5. Repair Types, Procedures - Part 1

    Science.gov (United States)

    2010-05-01

    New Jersey, USA. Repair Types, Procedures – Part I RTO-EN-AVT-156 9 - 19 [5] Drieker R, Botello C, MacBeth S, and Grody J, “Aircraft Battle... MacBeth S, and Grody J, “Aircraft Battle Damage Assessment and Repair (ABDAR), Vol. III: Field Test Report,” AFRL-HE-WP-TR-2002-0039, July 2000. [8

  6. Safety assessment in plant layout design using indexing approach: implementing inherent safety perspective. Part 1 - guideword applicability and method description.

    Science.gov (United States)

    Tugnoli, Alessandro; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio

    2008-12-15

    Layout planning plays a key role in the inherent safety performance of process plants since this design feature controls the possibility of accidental chain-events and the magnitude of possible consequences. A lack of suitable methods to promote the effective implementation of inherent safety in layout design calls for the development of new techniques and methods. In the present paper, a safety assessment approach suitable for layout design in the critical early phase is proposed. The concept of inherent safety is implemented within this safety assessment; the approach is based on an integrated assessment of inherent safety guideword applicability within the constraints typically present in layout design. Application of these guidewords is evaluated along with unit hazards and control devices to quantitatively map the safety performance of different layout options. Moreover, the economic aspects related to safety and inherent safety are evaluated by the method. Specific sub-indices are developed within the integrated safety assessment system to analyze and quantify the hazard related to domino effects. The proposed approach is quick in application, auditable and shares a common framework applicable in other phases of the design lifecycle (e.g. process design). The present work is divided in two parts: Part 1 (current paper) presents the application of inherent safety guidelines in layout design and the index method for safety assessment; Part 2 (accompanying paper) describes the domino hazard sub-index and demonstrates the proposed approach with a case study, thus evidencing the introduction of inherent safety features in layout design.

  7. Microelectronic Status Analysis and Secondary Part Procureability Assessment of the THAAD Weapon System

    National Research Council Canada - National Science Library

    Maddux, Gary

    1999-01-01

    The Industrial Operations Division (IOD), SEPD, RDEC, AMCOM has the mission and function of providing microelectronic technology assessments, and producibility and supportability analyses for the THAAD weapon system...

  8. Preliminary Guideline for the High Temperature Structure Integrity Assessment Procedure Part I. High Temperature Structure Design Guide

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Han; Kim, J. B.; Lee, H. Y.; Park, C. G.; Joo, Y. S.; Koo, G. H.; Kim, S. H

    2007-02-15

    A preliminary guideline for the design and evaluation of LMR high temperature structure is presented based upon ASME B and PV Code, Section III, Subsection NH. The main contents of this guideline are the materials, general design, vessel, piping, core support structure, pumps, valves, fabrication, examination, and testing for the class 1 components. The ratcheting evaluation, enhanced creep assessment, welds design and evaluation, inelastic analysis approach, piping design alternatives, and bellows design method are described in appendices. A user of this guideline should follow the essential procedures and may refer to other pertinent codes, standards, laws, regulations, or other pertinent documents when this guideline does not lead to proper design of the structure. While this guideline adopts major procedures of Subsection NH, it refers to the RCC-MR and/or DDS in some amount for the items where these codes have excellency to improve this guideline.

  9. Environmental assessment of three egg production systems--Part I: Monitoring system and indoor air quality.

    Science.gov (United States)

    Zhao, Y; Shepherd, T A; Li, H; Xin, H

    2015-03-01

    To comprehensively assess conventional vs. some alternative laying-hen housing systems under U.S. production conditions, a multi-institute and multi-disciplinary project, known as the Coalition for Sustainable Egg Supply (CSES) study, was carried out at a commercial egg production farm in the Midwestern United States over two single-cycle production flocks. The housing systems studied include a conventional cage house (200,000 hen capacity), an aviary house (50,000 hen capacity), and an enriched colony house (50,000 hen capacity). As an integral part of the CSES project, continual environmental monitoring over a 27-month period described in this paper quantifies indoor gaseous and particulate matter concentrations, thermal environment, and building ventilation rate of each house. Results showed that similar indoor thermal environments in all three houses were maintained through ventilation management and environmental control. Gaseous and particulate matter concentrations of the enriched colony house were comparable with those of the conventional cage house. In comparison, the aviary house had poorer indoor air quality, especially in wintertime, resulting from the presence of floor litter (higher ammonia levels) and hens' activities (higher particulate matter levels) in it. Specifically, daily mean indoor ammonia concentrations had the 95% confidence interval values of 3.8 to 4.2 (overall mean of 4.0) ppm for the conventional cage house; 6.2 to 7.2 (overall mean of 6.7) ppm for the aviary house; and 2.7 to 3.0 (overall mean of 2.8) ppm for the enriched colony house. The 95% confidence interval (overall mean) values of daily mean indoor carbon dioxide concentrations were 1997 to 2170 (2083) ppm for the conventional cage house, 2367 to 2582 (2475) ppm for the aviary house, and 2124 to 2309 (2216) ppm for the enriched colony house. Daily mean indoor methane concentrations were similar for all three houses, with 95% confidence interval values of 11.1 to 11.9 (overall

  10. Risk Assessment of Bioaccumulation Substances. Part II: Description of a Model Framework

    NARCIS (Netherlands)

    Tamis, J.E.; Vries, de P.; Karman, C.C.

    2009-01-01

    This report provides a proposal for a framework for risk assessment of bioaccumulative substances, either from produced water discharges or present as background contamination. The proposed framework is such that it is compatible to the current EIF risk assessment models that are used in the

  11. Rapid Assessment of Loiasis in parts of the Niger Delta, in Imo State ...

    African Journals Online (AJOL)

    The prevalence of loiasis was rapidly assessed based on the World Health Organisation RAPLOA technique in 24 rural communities of the Niger Delta Area of Imo State, Nigeria using 78-82 adults per community. The rapid assessment was based on history of eye worm and Calabar swellings from individual, as well as ...

  12. Volume-based assessment by {sup 18}F-FDG PET/CT predicts survival in patients with stage III non-small-cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hyun, Seung Hyup; Choi, Joon Young [Sungkyunkwan University School of Medicine, Department of Nuclear Medicine, Samsung Medical Center, Seoul (Korea, Republic of); Ahn, Hee Kyung [Gachon University Gil Hospital, Division of Hematology-Oncology, Department of Internal Medicine, Incheon (Korea, Republic of); Kim, Hojoong [Sungkyunkwan University School of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Seoul (Korea, Republic of); Ahn, Myung-Ju; Park, Keunchil [Sungkyunkwan University School of Medicine, Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Seoul (Korea, Republic of); Ahn, Yong Chan [Sungkyunkwan University School of Medicine, Department of Radiation Oncology, Samsung Medical Center, Seoul (Korea, Republic of); Kim, Jhingook; Shim, Young Mog [Sungkyunkwan University School of Medicine, Department of Thoracic Surgery, Samsung Medical Center, Seoul (Korea, Republic of)

    2014-01-15

    We evaluated the prognostic impact of volume-based assessment by {sup 18}F-FDG PET/CT in patients with stage III non-small-cell lung cancer (NSCLC). We reviewed 194 consecutive patients with stage IIIA NSCLC treated with surgical resection (surgical group) and 115 patients treated with nonsurgical therapy (nonsurgical group: 50 stage IIIA, 65 stage IIIB). Metabolic tumour volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) of primary tumours were measured using pretreatment {sup 18}F-FDG PET/CT. Overall survival was assessed using the Kaplan-Meier method. The prognostic significance of PET parameters and other clinical variables was assessed using Cox proportional hazards regression analyses. To evaluate and compare the predictive performance of PET parameters, time-dependent receiver operating characteristic (ROC) curve analysis was used. In the Cox proportional hazards models, MTV (HR = 1.27 for a doubling of MTV, P = 0.008) and TLG (HR = 1.22 for a doubling of TLG, P = 0.035) were significantly associated with an increased risk of death after adjusting for age, gender, histological cell type, T stage, N stage, and treatment variables in the surgical group. SUVmax was not a significant prognostic factor in either the surgical or nonsurgical group. In the time-dependent ROC curve analysis, volume-based PET parameters predicted survival better than SUVmax. The volume-based PET parameters (MTV and TLG) are significant prognostic factors for survival independent of tumour stage and better prognostic imaging biomarkers than SUVmax in patients with stage IIIA NSCLC after surgical resection. (orig.)

  13. Fourier Transform Infrared Spectroscopy Part III. Applications.

    Science.gov (United States)

    Perkins, W. D.

    1987-01-01

    Discusses the use of the FT-IR spectrometer in analyses that were previously avoided. Examines some of the applications of this spectroscopy with aqueous solutions, circular internal reflection, samples with low transmission, diffuse reflectance, infrared emission, and the infrared microscope. (TW)

  14. [Medicine in notafilia--Part III].

    Science.gov (United States)

    Babić, Rade R; Babić, Gordana Stanković

    2013-01-01

    Notafilia is the study of paper money. Only a few countries in the world have issued banknotes with portraits of well-known scientists who brought international fame to their own people and medicine. PORTRAITS OF SCIENTISTS ON THE BANKNOTES OF YUGOSLAVIA, SERBIA AND MONTENEGRO AND SERBIA. Nikola Tesla and Mihailo Pupin Idvorski were the ingenious inventors and scientists of our time who made special contributions to radiology. Nikola Tesla (1856-1943) pioneered the use of X-rays for medical purposes, thus effectively laying the foundations of radiology and radiography, and revealed the existence of harmful effects of X-rays on the human body. Mihailo Pupin Idvorski (1854-1935) was worldwide famous for applying physics in practice, as well as in the basis of telephone and telegraph transmissions. He also studied the nature of X-rays and contributed to establishing of radiology. PORTRAITS OF SCIENTISTS ON THE BANKNOTES OF THE WORLD: Maria Sklodowska Curie (1867-1934) was the first woman to gain the academic title of the Academy of Medicine, Paris. Together with her husband Pierre Curie (1859-1906) she gave an outstanding contribution to science and medicine. The discovery of the radioactive elements introduced the concept of "radioactivity" into physics and "radiotherapy" as a new discipline in medicine, thus creating the conditions for the development of nuclear medicine, oncology, and mobile diagnostic radiology. This paper presents the banknotes featuring the portraits of Nikola Tesla, Mihailo Pupin Idvorski, Maria Sklodowska Curie and Pierre Curie, the world renowned scientists, who made enormous contributions to medicine and laid the foundation for radiology.

  15. Part III. Ultrasound in rheumatology practice

    Directory of Open Access Journals (Sweden)

    Anastasia Borisovna Demina

    2013-12-01

    Full Text Available On 23–25 May 2013, the Karolinska Institute (Stockholm, Sweden with the support of MSD company held a meeting on a Clinical Observational Program for rheumatologists, which was attended by the well-known rheumatologists and leading specialists of the Institute Prof. R. van Vollenhoven, Prof. L. Klareskog, Dr. E. af Klint, and Dr. C. Carlens. The reports and interactive sessions discussed the problems of rheumatoid arthritis (RA, including early RA (pathology, pathogenesis, and treatment, registers of with rheumatic diseases; ultrasound diagnosis of inflammatory locomotor diseases; biological therapy for rheumatic diseases; organization of work in the research immunological laboratory, outpatient/day hospital units of a rheumatology clinic. The Program was also attended by physicians from different European countries (Sweden, Germany, Russia, Spain, Greece, etc.. Below is given an overview of the proceedings of the Clinical Observational Program.

  16. Topics in Finance Part III--Leverage

    Science.gov (United States)

    Laux, Judy

    2010-01-01

    This article investigates operating and financial leverage from the perspective of the financial manager, accenting the relationships to stockholder wealth maximization (SWM), risk and return, and potential agency problems. It also covers some of the pertinent literature related specifically to the implications of operating and financial risk and…

  17. Acardiac twin pregnancies part III : Model simulations

    NARCIS (Netherlands)

    van Gemert, Martin J C; Ross, Michael G.; Nikkels, Peter G J|info:eu-repo/dai/nl/074234692; Wijngaard, Jeroen P H M van den

    2016-01-01

    Background: Acardiac monochorionic twins lack cardiac function but grow by passive perfusion of the pump twin's deoxygenated arterial blood through placental arterioarterial (AA) and venovenous (VV) anastomoses and by hypoxia-mediated neovascularization. Pump twins therefore must continuously

  18. Projekt Kitae Part I-III

    DEFF Research Database (Denmark)

    Mitchell, William Dr.

    Fokuserer på udfordringerne omkring nuværende militære C2 organisation med henblik på at maksimere kamppladsens "smidighed" (Agility). Dette ord er i studiet defineret ved "C2 strukturens evne til at facilitere transformationen af indhentet kendskab fra den komplekse kampplads i en rettidig tidsr...

  19. MATLAB-Based Applications for Image Processing and Image Quality AssessmentPart I: Software Description

    Directory of Open Access Journals (Sweden)

    L. Krasula

    2011-12-01

    Full Text Available This paper describes several MATLAB-based applications useful for image processing and image quality assessment. The Image Processing Application helps user to easily modify images, the Image Quality Adjustment Application enables to create series of pictures with different quality. The Image Quality Assessment Application contains objective full reference quality metrics that can be used for image quality assessment. The Image Quality Evaluation Applications represent an easy way to compare subjectively the quality of distorted images with reference image. Results of these subjective tests can be processed by using the Results Processing Application. All applications provide Graphical User Interface (GUI for the intuitive usage.

  20. A model to assess water tariffs as part of water demand management

    African Journals Online (AJOL)

    Water Conservation and Water Demand Management (WC/WDM) forms part of integrated water resource management and can be used as an economically viable alternative to the upgrade of infrastructure to balance supply and demand. In order to enable effective decision-making, a model was developed in this study to ...

  1. Assessment of two different diagnostic guidelines criteria (National Cholesterol Education Adult Treatment Panel III [ATP III] and International Diabetes Federation [IDF]) for the evaluation of metabolic syndrome remission in a longitudinal cohort of patients undergoing Roux-en-Y gastric bypass.

    Science.gov (United States)

    Rodríguez-Ortiz, Donají; Reyes-Pérez, Azucena; León, Pablo; Sánchez, Hugo; Mosti, Maureen; Aguilar-Salinas, Carlos A; Velázquez-Fernández, David; Herrera, Miguel F

    2016-04-01

    Bariatric surgery has proven to provide durable weight loss and control of comorbid conditions, including the metabolic syndrome (MS). Existing definitions of MS have caused substantial confusion regarding their concordance for identifying the same individuals. The aim of this study was to assess the value of 2 different diagnostic guidelines criteria (National Cholesterol Education Adult Treatment Panel III [ATP III] and International Diabetes Federation [IDF]) for the evaluation of remission of MS after Roux-en-Y gastric bypass (RYGB). A cohort of 381 patients who underwent a primary RYGB, satisfied the criteria for MS, and had at least o1 postoperative visit were selected. Weight loss and MS remission were analyzed 6 and 12 months after surgery by ATP III and IDF criteria. Before surgery, 381 (48.9%) and 354 (45.4%) patients fulfilled the criteria for MS according to the ATP III and IDF, respectively. According to the ATP III definition, remission of MS after bariatric surgery occurred in 209 of 239 (87.4%) and 98/102 (96.1%) patients at 6 and 12 months, respectively. According to the IDF definition, this occurred in 180 of 232 (77.6%) and 54 of 64 (84.4%) at the same time periods. On the basis of different percentage of excess body weight loss cut-off values, the area under the curve in receiver operating characteristic analysis at 12 months was slightly better for ATP III (0.77) than IDF criteria (0.68) for remission of MS. With the use of the IDF definition, the remission rate of MS was 10% more rigorous than with use of the ATP-III criteria. This feature is attributable to a greater discrimination of patients with high blood pressure, glycemia, and dyslipidemia. The IDF criteria seem more accurate to evaluate MS remission. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. European clinical guidelines for Tourette syndrome and other tic disorders. Part I: assessment

    DEFF Research Database (Denmark)

    Cath, Danielle C; Hedderly, Tammy; Ludolph, Andrea G

    2011-01-01

    members. Detailed clinical assessment guidelines of tic disorders and their comorbidities in both children and adults are presented. Screening methods that might be helpful and necessary for specialists' differential diagnosis process are suggested in order to further analyse cognitive abilities...

  3. Expanding the neurological examination using functional neurologic assessment: part II neurologic basis of applied kinesiology.

    Science.gov (United States)

    Schmitt, W H; Yanuck, S F

    1999-03-01

    Functional Neurologic Assessment and treatment methods common to the practice of applied kinesiology are presented. These methods are proposed to enhance neurological examination and treatment procedures toward more effective assessment and care of functional impairment. A neurologic model for these procedures is proposed. Manual assessment of muscular function is used to identify changes associated with facilitation and inhibition, in response to the introduction of sensory receptor-based stimuli. Muscle testing responses to sensory stimulation of known value are compared with usually predictable patterns based on known neuroanatomy and neurophysiology, guiding the clinician to an understanding of the functional status of the patient's nervous system. These assessment procedures are used in addition to other standard diagnostic measures to augment rather than replace the existing diagnostic armamentarium. The proper understanding of the neurophysiologic basis of muscle testing procedures will assist in the design of further investigations into applied kinesiology. Accordingly, the neurophysiologic basis and proposed mechanisms of these methods are reviewed.

  4. Microelectronics Status Analysis and Secondary Part Procureability Assessment of the THAAD Weapon System

    National Research Council Canada - National Science Library

    Maddux, Gary

    1999-01-01

    The Manufacturing Science and Technology Division (MS&TD), AMCOM has the mission and function of providing microelectronic technology assessments, and producibility and supportability analyses for the THAAD weapon system...

  5. Serum antithrombin III level is well correlated with multiple indicators for assessment of liver function and diagnostic accuracy for predicting postoperative liver failure in hepatocellular carcinoma patients.

    Science.gov (United States)

    Mizuguchi, Toru; Kawamoto, Masaki; Meguro, Makoto; Son, Seiichi; Nakamura, Yukio; Harada, Kohei; Shibata, Toshihito; Ota, Shigenori; Hirata, Koichi

    2012-01-01

    Evaluation of preoperative hepatic reserve is critical to avoid a fatal clinical course such as liver failure. We retrospectively evaluated 158 consecutive hepatocellular carcinoma (HCC) patients who underwent initial hepatectomy. The aim of this study was to determine the correlations of multiple indicators for assessment of liver function before hepatectomy. Furthermore, diagnostic probability for the pathological background and prediction of postoperative liver failure/dysfunction was compared between the antithrombin (AT) III level and indocyanine green retention rate at 15 minutes (ICGR15). Between January 2001 and March 2008, 158 HCC patients who underwent initial hepatectomy were enrolled in this study. Spearman's correlation coefficients (r values) were obtained for 15 clinical laboratory tests including ATIII and ICGR15. Receiver operating characteristic (ROC) curve analysis was used for calculating the probability and predictive ability of the tests. All 158 consecutive HCC patients were eligible for hepatectomy based on the Japanese guideline. ATIII is correlated with 13 of 14 other clinical tests, including albumin, bilirubin, prothrombin time, rapid turnover proteins, HGF, ICGR15 and others. The diagnostic probabilities to distinguish between normal liver and other pathological backgrounds of ATIII and ICGR15 were significantly different. The specificity of ATIII to predict postoperative liver failure/dysfunction was higher than that of ICGR15. The serum ATIII level before hepatectomy is valuable to estimate the pathological background and predict postoperative liver failure/ dysfunction. It should be possible to use ATIII as an additional indicator for liver function and substitute for ICGR15 in the future.

  6. DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer

    DEFF Research Database (Denmark)

    Nygård, Sune Boris; Vainer, Ben; Nielsen, Signe L

    2016-01-01

    PURPOSE: Prospective-retrospective assessment of the TOP1 gene copy number and TOP1 mRNA expression as predictive biomarkers for adjuvant irinotecan in stage II/III colon cancer (CC). EXPERIMENTAL DESIGN: Formalin-fixed, paraffin-embedded tissue microarrays were obtained from an adjuvant CC trial...... (PETACC3) where patients were randomized to 5-fluorouracil/folinic acid with or without additional irinotecan. TOP1 copy number status was analyzed by fluorescence in situ hybridization (FISH) using a TOP1/CEN20 dual-probe combination. TOP1 mRNA data were available from previous analyses. RESULTS: TOP1...... FISH and follow-up data were obtained from 534 patients. TOP1 gain was identified in 27 % using a single-probe enumeration strategy (≥ 4 TOP1 signals per cell), and in 31 % when defined by a TOP1/CEN20 ratio ≥ 1.5. The effect of additional irinotecan was not dependent on TOP1 FISH status. TOP1 m...

  7. Climate change impact assessment in Veneto and Friuli Plain groundwater. Part II: a spatially resolved regional risk assessment.

    Science.gov (United States)

    Pasini, S; Torresan, S; Rizzi, J; Zabeo, A; Critto, A; Marcomini, A

    2012-12-01

    Climate change impact assessment on water resources has received high international attention over the last two decades, due to the observed global warming and its consequences at the global to local scale. In particular, climate-related risks for groundwater and related ecosystems pose a great concern to scientists and water authorities involved in the protection of these valuable resources. The close link of global warming with water cycle alterations encourages research to deepen current knowledge on relationships between climate trends and status of water systems, and to develop predictive tools for their sustainable management, copying with key principles of EU water policy. Within the European project Life+ TRUST (Tool for Regional-scale assessment of groundwater Storage improvement in adaptation to climaTe change), a Regional Risk Assessment (RRA) methodology was developed in order to identify impacts from climate change on groundwater and associated ecosystems (e.g. surface waters, agricultural areas, natural environments) and to rank areas and receptors at risk in the high and middle Veneto and Friuli Plain (Italy). Based on an integrated analysis of impacts, vulnerability and risks linked to climate change at the regional scale, a RRA framework complying with the Sources-Pathway-Receptor-Consequence (SPRC) approach was defined. Relevant impacts on groundwater and surface waters (i.e. groundwater level variations, changes in nitrate infiltration processes, changes in water availability for irrigation) were selected and analyzed through hazard scenario, exposure, susceptibility and risk assessment. The RRA methodology used hazard scenarios constructed through global and high resolution model simulations for the 2071-2100 period, according to IPCC A1B emission scenario in order to produce useful indications for future risk prioritization and to support the addressing of adaptation measures, primarily Managed Artificial Recharge (MAR) techniques. Relevant

  8. Battlefield Damage Assessment and Repair: Is Improvised Maintenance the Battlefield Solution to the Repair Parts Dilemma

    Science.gov (United States)

    1993-12-14

    decade, under Secretary of Defense Robert S. McNamara, operations research (specifically, cost-benefit 8 analysis) became a primary tool for military...be preferable: Equating A. and CA., using x to represent the break-even BDAR capability may be represented by the equation: Ao=40%= (10 houzs - I hour...commanders to overcome the problems of non-availability of repair parts through "[scrounging] and cannibalization." 38. McFarlin, Robert P., Memorandum

  9. Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial.

    Science.gov (United States)

    Collett, Laura; Howard, Dena R; Munir, Talha; McParland, Lucy; Oughton, Jamie B; Rawstron, Andy C; Hockaday, Anna; Dimbleby, Claire; Phillips, David; McMahon, Kathryn; Hulme, Claire; Allsup, David; Bloor, Adrian; Hillmen, Peter

    2017-08-22

    Treatment of chronic lymphocytic leukaemia (CLL) has seen a substantial improvement over the last few years. Combination immunochemotherapy, such as fludarabine, cyclophosphamide and rituximab (FCR), is now standard first-line therapy. However, the majority of patients relapse and require further therapy, and so new, effective, targeted therapies that improve remission rates, reduce relapses, and have fewer side effects, are required. The FLAIR trial will assess whether ibrutinib plus rituximab (IR) is superior to FCR in terms of progression-free survival (PFS). FLAIR is a phase III, multicentre, randomised, controlled, open, parallel-group trial in patients with previously untreated CLL. A total of 754 participants will be randomised on a 1:1 basis to receive standard therapy with FCR or IR. Participants randomised to FCR will receive a maximum of six 28-day treatment cycles. Participants randomised to IR will receive six 28-day cycles of rituximab, and ibrutinib taken daily for 6 years until minimal residual disease (MRD) negativity has been recorded for the same amount of time as it took to become MRD negative, or until disease progression. The primary endpoint is PFS according to the International Workshop on CLL (IWCLL) criteria. Secondary endpoints include: overall survival; proportion of participants with undetectable MRD; response to therapy by IWCLL criteria; safety and toxicity; health-related quality of life (QoL); and cost-effectiveness. The trial aims to provide evidence for the future first-line treatment of CLL patients by assessing whether IR is superior to FCR in terms of PFS, and whether toxicity rates are favourable. ISRCTN01844152 . Registered on 8 August 2014, EudraCT number 2013-001944-76 . Registered on 26 April 2013.

  10. European consumer exposure to cosmetic products, a framework for conducting population exposure assessments Part 2.

    Science.gov (United States)

    Hall, B; Steiling, W; Safford, B; Coroama, M; Tozer, S; Firmani, C; McNamara, C; Gibney, M

    2011-02-01

    Access to reliable exposure data is essential for the evaluation of the toxicological safety of ingredients in cosmetic products. This study complements the data set obtained previously (Part 1) and published in 2007 by the European cosmetic industry acting within COLIPA. It provides, in distribution form, exposure data on daily quantities of five cosmetic product types: hair styling, hand cream, liquid foundation, mouthwash and shower gel. In total 80,000 households and 14,413 individual consumers in five European countries provided information using their own products. The raw data were analysed using Monte Carlo simulation and a European Statistical Population Model of exposure was constructed. A significant finding was an inverse correlation between the frequency of product use and the quantity used per application recorded for mouthwash and shower gel. The combined results of Part 1 (7 product types) and Part 2 (5 products) reported here, bring up to date and largely confirm the current exposure parameters concerning some 95% of the estimated daily exposure to cosmetics use in the EU. The design of this study, with its relation to demographic and individual diversity, could serve as a model for studies of populations' exposure to other consumer products. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. Structured functional assessments in general practice increased the use of part-time sick leave: a cluster randomised controlled trial.

    Science.gov (United States)

    Osterås, Nina; Gulbrandsen, Pål; Kann, Inger Cathrine; Brage, Søren

    2010-03-01

    A method for structured functional assessments of persons with long-term sick leave was implemented in a cluster randomised controlled trial in general practice. The aim was to analyse intervention effects on general practitioner (GP) sick-listing practice and patient sick leave. 57 GPs were randomly assigned to an intervention or a control group. The intervention group GPs learned the method at a 1-day workshop including teamwork and role-playing. The control group GPs were requested to assess functional ability as usual during the 8 months intervention period in 2005. Outcome measures included duration of patient sick leave episodes, GP prescription of part-time sick leave, active sick leave, and vocational rehabilitation. This data was extracted from a national register. The GPs in the intervention group prescribed part-time sick leave more often (p part-time and less active sick leave compared to the control group GPs. As a result, more intervention GP patients returned to part-time work compared to control GP patients. No intervention effect was seen on duration of patient sick leave episodes or on prescription of vocational rehabilitation.

  12. Inventory of LCIA selection methods for assessing toxic releases. Methods and typology report part B

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Birkved, Morten; Hauschild, Michael Zwicky

    This report describes an inventory of Life Cycle Impact Assessment (LCIA) selection methods for assessing toxic releases. It consists of an inventory of current selection methods and other Chemical Ranking and Scoring (CRS) methods assessed to be relevant for the development of (a) new selection...... method(s) in Work package 8 (WP8) of the OMNIITOX project. The selection methods and the other CRS methods are described in detail, a set of evaluation criteria are developed and the methods are evaluated against these criteria. This report (Deliverable 11B (D11B)) gives the results from task 7.1d, 7.1e...... by a characterisation method for the impact categories covering ecotoxicity and human toxicity. A selection method is therefore not a characterisation method like the “simple base method” and the “base method” that are going to be developed within WP8 but the purpose of a selection method is to focus the effort within...

  13. Collision Avoidance Short Course: Conjunction Assessment Risk Analysis - NASA Robotic CARA. Part I: ; Theory

    Science.gov (United States)

    Hejduk, M. D.; Frigm, Ryan C.

    2015-01-01

    Satellite conjunction assessment is perhaps the fastest growing area in space situational awareness and protection with military, civil and commercial satellite owner-operators embracing more and more sophisticated processes to avoid the avoidable - namely collisions between high value space assets and orbital debris. NASA and Centre National d'Etudes Spatiales (CNES) have collaborated to offer an introductory short course on all the major aspects of the conjunctions assessment problem. This half-day course will cover satellite conjunction dynamics and theory. Joint Space Operations Center (JsPOC) conjunction data products, major risk assessment parameters and plots, conjunction remediation decision support, and present and future challenges. This briefing represents the NASA portion of the course.

  14. Optimizing physician skill development for medical students: The four-part assessment.

    Science.gov (United States)

    Watson, Justin J J; Bohan, Phillip M Kemp; Ramsey, Katrina; Yonge, John D; Connelly, Christopher R; Mullins, Richard J; Watters, Jennifer M; Schreiber, Martin A; Kiraly, Laszlo N

    2017-05-01

    Medical student performance has been poorly correlated with residency performance and warrants further investigation. We propose a novel surgical assessment tool to determine correlations with clinical aptitude. Retrospective review of medical student assessments from 2013 to 2015. Faculty rating of student performance was evaluated by: 1) case presentation, 2) problem definition, 3) question response and 4) use of literature and correlated to final exam assessment. A Likert scale interrater reliability was evaluated. Sixty student presentations were scored (4.8 assessors/presentation). A student's case presentation, problem definition, and question response was correlated with performance (r = 0.49 to 0.61, p ≤ 0.003). Moderate correlations for either question response or use of literature was demonstrated (0.3 and 0.26, p grades for medical students. As surgical education evolves, validated performance and reliable testing measures are required. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Pre-admission nursing assessment in a Welsh Medium Secure Unit (1991-2000): Part 2--comparison of traditional nursing assessment with the HCR-20 risk assessment tool.

    Science.gov (United States)

    Watt, Andrew; Topping-Morris, Barry; Rogers, Paul; Doyle, Mike; Mason, Tom

    2003-08-01

    Pre-admission forensic nursing assessment is a tradition that has no research evidence base, little documentary support and is an expensive drain on nursing resources from clinical environments. Such an expensive practice warrants some evaluation of the quality of these nursing assessments. This study assessed the quality of nursing risk assessments through comparison with the HCR-20, a well-established and widely validated violence risk assessment instrument. There was a high degree of correspondence between nurse assessments and the contents of the HCR-20. The results offer support for forensic nurses' abilities to develop effective measures and practices based upon nursing knowledge and experience where no formal evidence base previously existed.

  16. A comparative assessment of non-laboratory-based versus commonly used laboratory-based cardiovascular disease risk scores in the NHANES III population.

    Directory of Open Access Journals (Sweden)

    Ankur Pandya

    Full Text Available National and international primary CVD risk screening guidelines focus on using total CVD risk scores. Recently, we developed a non-laboratory-based CVD risk score (inputs: age, sex, smoking, diabetes, systolic blood pressure, treatment of hypertension, body-mass index, which can assess risk faster and at lower costs compared to laboratory-based scores (inputs include cholesterol values. We aimed to assess the exchangeability of the non-laboratory-based risk score to four commonly used laboratory-based scores (Framingham CVD [2008, 1991 versions], and Systematic COronary Risk Evaluation [SCORE] for low and high risk settings in an external validation population.Analyses were based on individual-level, score-specific rankings of risk for adults in the Third National Health and Nutrition Examination Survey (NHANES III aged 25-74 years, without history of CVD or cancer (n = 5,999. Risk characterization agreement was based on overlap in dichotomous risk characterization (thresholds of 10-year risk >10-20% and Spearman rank correlation. Risk discrimination was assessed using receiver operator characteristic curve analysis (10-year CVD death outcome. Risk characterization agreement ranged from 91.9-95.7% and 94.2-95.1% with Spearman correlation ranges of 0.957-0.980 and 0.946-0.970 for men and women, respectively. In men, c-statistics for the non-laboratory-based, Framingham (2008, 1991, and SCORE (high, low functions were 0.782, 0.776, 0.781, 0.785, and 0.785, with p-values for differences relative to the non-laboratory-based score of 0.44, 0.89, 0.68 and 0.65, respectively. In women, the corresponding c-statistics were 0.809, 0.834, 0.821, 0.792, and 0.792, with corresponding p-values of 0.04, 0.34, 0.11 and 0.09, respectively.Every score discriminated risk of CVD death well, and there was high agreement in risk characterization between non-laboratory-based and laboratory-based risk scores, which suggests that the non-laboratory-based score can

  17. The two-stroke poppet valve engine. Part 1: Intake and exhaust ports flow experimental assessments

    Science.gov (United States)

    Kamili Zahidi, M.; Razali Hanipah, M.; Ramasamy, D.; Noor, M. M.; Kadirgama, K.; Rahman, M. M.

    2017-10-01

    A two-stroke poppet valve engine is developed to overcome the common problems in conventional two-stroke engine designs. However, replacing piston control port with poppet valve will resulted different flow behaviour. This paper is looking at experimental assessment on a two-stroke poppet valve engine configuration to investigate the port flow performance. The aims are to evaluate the intake and exhaust coefficient of discharge and assess the twostroke capability of the cylinder head. The results has shown comparable coefficient of discharge values as production engine for the intake while the exhaust has higher values which is favourable for the two-stroke cycle operation.

  18. Direct and indirect drift assessment means. Part 4: a comparative study.

    Science.gov (United States)

    Nuyttens, D; Baetens, K; De Schampheleire, M; Sonck, B

    2008-01-01

    Three contrasting drift risk assessment means were evaluated when predicting absolute losses of sedimenting pesticide drift from field crop sprayers namely PDPA laser measurements, wind tunnel measurements (both indirect drift risk assessment means) and field drift experiments (direct drift risk assessment means). In total, 90 PDPA laser measurements, 45 wind tunnel experiments and 61 field drift experiments were performed with 10 different spray nozzles at a pressure of 3.0 bar. The effect of nozzle size (ISO 02, 03 04 and 06) and nozzle type (standard flat fan, low-drift flat fan, air inclusion) on the amount of near-field sedimenting spray drift was studied. The reference spray application was defined as a Hardi ISO F 110 03 standard flat fan nozzle at a pressure of 3.0 bar with a nozzle or boom height of 0.50 m and a driving speed of 8 km.h(-1) for the field measurements; conditions that were always used for the comparative assessment of the different investigated nozzle-pressure combinations. A comparison is made between the results obtained with the indirect drift assessment means and the direct drift assessment method to evaluate the potential of these three different drift assessment means. Droplet size as well as droplet velocity characteristics are related with DRPt (field experiments) and DPRP (wind tunnel experiments). Because of the strong intercorrelation between droplet size and velocity characteristics for the nozzle-pressure combinations investigated in this study, simple first-order linear regressions with one of the droplet characteristics as a predictor variable, were the best choice to predict DRPt and DPRP. Results showed that with the indirect risk assessment means (wind tunnel and PDPA laser measurement), driftability experiments can be made with different spraying systems under directly comparable and repeatable conditions and both methods are suited to permit relative studies of drift risk. Moreover, based on these indirect drift

  19. Conscious worst case definition for risk assessment, part II: a methodological case study for pesticide risk assessment.

    Science.gov (United States)

    Sørensen, Peter B; Giralt, Francesc; Rallo, Robert; Espinosa, Gabriela; Münier, Bernd; Gyldenkaerne, Steen; Thomsen, Marianne

    2010-08-15

    This paper illustrates, by a case study, how to apply the conceptual Worst-Case Definition (WCD) model, developed in the methodological paper in the current journal, by Sørensen et al. (2010-this issue). The case is about eco-toxicological risk assessment of pesticides under Danish conditions. Cumulative aspects are included on a conceptual basis as elements of the worst-case conditions. This defines factors that govern the risk assessment, including location in time and space of risk "hotspots". Two pillars of concern drive the conceptual modelling: (1) What to protect (denoted Protected Units (PUs)) and (2) the reason for increased risk level (denoted Causes of Risks (CRs)). Both PUs and CRs are analysed using hierarchical procedures that facilitate a complete listing of concrete factors governing increased risk for adverse effect due to agricultural usage of pesticide. The factors governing pesticide risk are combined in a context that combines the protection of relevant groupings of organisms with the factors for increased risk level for each of these. Identification of the most important relations between defined types of PUs and CRs is illustrated using expert knowledge. Existing databases are used to form spatial distributed risk indicators as estimators for a selection of important relations between PUs and CRs. This paper illustrates how the WCD model can break down the complex issue of uncertainty into fractions that are more open for evaluations. Finally, it shows application of risk indicators in a multi-criterion analysis using respectively self organizing mapping and partial order technique in a comparative analysis that highlights critical aspects of uncertainty, due to the ambiguity between single risk indicator rankings. Copyright 2009 Elsevier B.V. All rights reserved.

  20. O tratamento da Classe III: revisão sistemática - Parte I. Magnitude, direção e duração das forças na protração maxilar The treatment of Class III: systematic review - Part I. Magnitude, direction and duration of the forces in the maxillary protraction

    Directory of Open Access Journals (Sweden)

    Anna Paula Rocha Perrone

    2009-10-01

    Full Text Available INTRODUÇÃO: para o tratamento da Classe III durante o crescimento, a protração maxilar é a terapia mais relatada na literatura. Durante o tratamento, é requerida especial atenção à mecânica utilizada para a correção do problema. OBJETIVO: sintetizar as informações relativas à magnitude, direção e tempo diário da aplicação das forças, por meio de uma revisão sistemática. MÉTODOS: estudos foram identificados a partir de uma pesquisa eletrônica no Medline database - Entrez PubMed (178 artigos e Bireme (550 artigos, no período de janeiro de 1983 a dezembro de 2008. Após um criterioso processo de inclusão e exclusão, 56 estudos primários foram selecionados e submetidos a um segundo processo de seleção, restando 39 artigos. Foram calculados a média e o desvio-padrão, bem como os valores mínimos e máximos para a magnitude, a direção e a quantidade de horas de uso das forças de protração maxilar. RESULTADOS E CONCLUSÃO: as médias de magnitude, direção e duração das forças de protração maxilar foram de, respectivamente, 447,8 gramas, 27,5 graus de inclinação em relação ao Plano Oclusal, e 15,2 horas por dia.INTRODUCTION: For the treatment of Class III during growth, maxillary protraction therapy is the most reported in the literature. During the treatment is required special attention to the mechanics used to fix the problem. AIM: To synthesize informations about the magnitude, direction and time of daily application of forces, through a systematic review. METHODS: Studies were identified from an electronic search on Medline database - Entrez PubMed (178 articles and Bireme (550 articles, from January 1983 until December 2008. After rigorous process of inclusion and exclusion 56 primary studies were selected and subjected to a second selection process, remaining 39 articles. It was calculated the average and standard deviation, and the minimum and maximum values for magnitude, direction and usage

  1. Performance Assessment Design Principles Gleaned from Constructivist Learning Theory (Part 2)

    Science.gov (United States)

    Zane, Thomas W.

    2009-01-01

    Just as objectivist theories have provided foundations for traditional tests, constructivist theories can offer foundations for performance assessment design and development methods. The tenets and principles embedded in various learning theories provide a solid foundation that can be combined with psychometric principles to help assessment…

  2. The release of genetically modified crops into the environment - Part II. Overview of ecological risk assessment

    NARCIS (Netherlands)

    Conner, A.J.; Glare, T.R.; Nap, J.P.H.

    2003-01-01

    Despite numerous future promises, there is a multitude of concerns about the impact of GM crops on the environment. Key issues in the environmental assessment of GM crops are putative invasiveness, vertical or horizontal gene flow, other ecological impacts, effects on biodiversity and the impact of

  3. ILLUMINATION RESEARCH AS PART OF A VISUAL ASSESSMENT OF VISUALLY-IMPAIRED INDIVIDUALS

    NARCIS (Netherlands)

    CORNELISSEN, FW; KOOIJMAN, AC; DUMBAR, G; VANDERWILDT, G

    1991-01-01

    In this paper we describe a method for the preliminary assessment of the illumination needs of partially sighted individuals. The method is based on determining the smallest readable lettersize under different levels of illumination. Half of the partially sighted in our population had a performance

  4. System for assessing Aviation's Global Emissions (SAGE), part 1 : model description and inventory results

    Science.gov (United States)

    2007-07-01

    In early 2001, the US Federal Aviation Administration embarked on a multi-year effort to develop a new computer model, the System for assessing Aviation's Global Emissions (SAGE). Currently at Version 1.5, the basic use of the model has centered on t...

  5. Outcome Assessments in Children with Cerebral Palsy, Part II: Discriminatory Ability of Outcome Tools

    Science.gov (United States)

    Bagley, Anita M; Gorton, George; Oeffinger, Donna; Barnes, Douglas; Calmes, Janine; Nicholson, Diane; Damiano, Diane; Abel, Mark; Kryscio, Richard; Rogers, Sarah; Tylkowski, Chester

    2007-01-01

    Discriminatory ability of several pediatric outcome tools was assessed relative to Gross Motor Function Classification System (GMFCS) level in patients with cerebral palsy. Five hundred and sixty-two patients (400 with diplegia, 162 with hemiplegia; 339 males, 223 females; age range 4-18y, mean 11y 1mo [SD 3y 7mo]), classified as GMFCS Levels I to…

  6. European clinical guidelines for Tourette Syndrome and other tic disorders. Part I : assessment

    NARCIS (Netherlands)

    Cath, Danielle C.; Hedderly, Tammy; Ludolph, Andrea G.; Stern, Jeremy S.; Murphy, Tara; Hartmann, Andreas; Czernecki, Virginie; Robertson, Mary May; Martino, Davide; Munchau, A.; Rizzo, R.

    A working group of the European Society for the Study of Tourette Syndrome (ESSTS) has developed the first European assessment guidelines of Tourette Syndrome (TS). The available literature including national guidelines was thoroughly screened and extensively discussed in the expert group of ESSTS

  7. IRIS Toxicological Review of Hexavalent Chromium Part 1: Experimental Animal Studies (Preliminary Assessment Materials)

    Science.gov (United States)

    In April 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for Cr(VI) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in...

  8. Assessment of Practical Skills. Part 2. Context Dependency and Construct Validity.

    Science.gov (United States)

    Lock, Roger

    1990-01-01

    Investigated are the context dependency and construct validity of practical skill assessment in science which may include the skills of observing, manipulating, planning, interpreting, reporting, and self-reliance. Pupil performance on a variety of practical tasks were compared with external examination grades in biology and chemistry. (CW)

  9. Non-destructive Assessment of Relief Marking Parameters of Heat Shrinkable Installation Parts for Aviation Technology

    Directory of Open Access Journals (Sweden)

    Kondratov Aleksandr P.

    2017-01-01

    Full Text Available The article explains a new method of relief marking of heat-shrinkable tubing and sleeves made of polymer materials with “shape memory effect.” Method of instrument evaluation of relief marking stereometry of installation parts for aviation equipment, made of polyvinyl chloride, polyethyleneterephthalate and polystyrene was developed and the results were explained. Parameters of pin-point relief marking and compliance of point forms to the Braille font standard were determined with the use of the non-destructive method based on the color of interference pattern with precision of 0.02 mm.

  10. The european flood alert system EFAS – Part 2: Statistical skill assessment of probabilistic and deterministic operational forecasts

    Directory of Open Access Journals (Sweden)

    J. C. Bartholmes

    2009-02-01

    Full Text Available Since 2005 the European Flood Alert System (EFAS has been producing probabilistic hydrological forecasts in pre-operational mode at the Joint Research Centre (JRC of the European Commission. EFAS aims at increasing preparedness for floods in trans-national European river basins by providing medium-range deterministic and probabilistic flood forecasting information, from 3 to 10 days in advance, to national hydro-meteorological services.

    This paper is Part 2 of a study presenting the development and skill assessment of EFAS. In Part 1, the scientific approach adopted in the development of the system has been presented, as well as its basic principles and forecast products. In the present article, two years of existing operational EFAS forecasts are statistically assessed and the skill of EFAS forecasts is analysed with several skill scores. The analysis is based on the comparison of threshold exceedances between proxy-observed and forecasted discharges. Skill is assessed both with and without taking into account the persistence of the forecasted signal during consecutive forecasts.

    Skill assessment approaches are mostly adopted from meteorology and the analysis also compares probabilistic and deterministic aspects of EFAS. Furthermore, the utility of different skill scores is discussed and their strengths and shortcomings illustrated. The analysis shows the benefit of incorporating past forecasts in the probability analysis, for medium-range forecasts, which effectively increases the skill of the forecasts.

  11. Methodologies of health impact assessment as part of an integrated approach to reduce effects of air pollution

    Energy Technology Data Exchange (ETDEWEB)

    Aunan, K.; Seip, H.M.

    1995-12-01

    Quantification of average frequencies of health effects on a population level is an essential part of an integrated assessment of pollution effects. Epidemiological studies seem to provide the best basis for such estimates. This paper gives an introduction to a methodology for health impact assessment and also the results from selected parts of a case study in Hungary. This case study is aimed at testing and improving the methodology for integrated assessment and focuses on energy production and consumption and implications for air pollution. Using monitoring data from Budapest, the paper gives estimates of excess frequencies of respiratory illness, mortality and other health end-points. For a number of health end-points, particles probably may serve as a good indicator component. Stochastic simulation is used to illustrate the uncertainties imbedded in the exposure-response function applied. The paper uses the ``bottom up approach`` to find cost-effective abatement strategies against pollution damages, where specific abatement measures such as emission standards for vehicles are explored in detail. It is concluded that in spite of large uncertainties in every step of the analysis, an integrated assessment of costs and benefits of different abatement measures is valuable as it clarifies the main objectives of an abatement policy and explicitly describes the adverse impacts of different activities and their relative importance. 46 refs., 11 figs., 2 tabs.

  12. Minimal intervention dentistry and older patients. Part 1: Risk assessment and caries prevention.

    Science.gov (United States)

    Hayes, Martina; Allen, Edith; da Mata, Cristiane; McKenna, Gerald; Burke, Francis

    2014-06-01

    Ten million people in the UK today are aged over 65. The latest projections estimate that there will be 5 1/2 million more people aged 65 and older in the next 20 years. This projected pattern of population ageing will have profound consequences for dentistry. Minimal intervention dentistry (MID) is a modern evidence-based approach to caries management in dentate patients that uses the 'medical model' whereby disease is controlled by the 'oral physician'. This approach offers considerable benefits over conventional dentistry for older patients. It encourages patients to be responsible for their oral health through the provision of both knowledge and motivation. MID encompasses risk assessment for dental disease, early detection and control of disease processes, and minimally invasive treatment. Clinical Relevance: Risk assessment tools can aid the general dental practitioner and the patient to develop a suitable caries prevention programme for that individual and reduce the need for future operative intervention.

  13. Checking Equity: Why Differential Item Functioning Analysis Should Be a Routine Part of Developing Conceptual Assessments

    Czech Academy of Sciences Publication Activity Database

    Martinková, Patrícia; Drabinová, Adéla; Liaw, Y.L.; Sanders, E.A.; McFarland, J.L.; Price, R.M.

    2017-01-01

    Roč. 16, June 1 (2017), č. článku rm2. ISSN 1931-7913 R&D Projects: GA ČR GJ15-15856Y Grant - others:NSF(US) DUE-1043443 Institutional support: RVO:67985807 Keywords : differential item functioning * fairness * conceptual assessments * concept inventory * undergraduate education * bias Subject RIV: AM - Education Impact factor: 3.930, year: 2016

  14. Ex Ante Impact Assessment of Policies Affecting Land Use, Part B: Application of the Analytical Framework

    Directory of Open Access Journals (Sweden)

    Katharina Helming

    2011-03-01

    Full Text Available The use of science-based tools for impact assessment has increasingly gained focus in addressing the complexity of interactions between environment, society, and economy. For integrated assessment of policies affecting land use, an analytical framework was developed. The aim of our work was to apply the analytical framework for specific scenario cases and in combination with quantitative and qualitative application methods. The analytical framework was tested for two cases involving the ex ante impact assessment of: (1 a European Common Agricultural Policy (CAP financial reform scenario employing a modeling approach and combined with a comprehensive indicator analysis and valuation; and (2 a regional bioenergy policy scenario, employing a fully participatory approach. The results showed that European land use in general is less sensitive to changes in the Common Agricultural Policy, but in the context of regions there can be significant impacts on the functions of land use. In general, the implementation of the analytical framework for impact assessment proved to be doable with both methods, i.e., with the quantitative modeling and with the qualitative participatory approach. A key advantage of using the system of linked quantitative models is that it makes possible the simultaneous consideration of all relevant sectors of the economy without abstaining from a great level of detail for sectors of particular interest. Other advantages lie in the incontestable character of the results. Based on neutral, existing data with a fixed set of settings and regions, an absolute comparability and reproducibility throughout Europe can be maintained. Analyzing the pros and cons of both approaches showed that they could be used complementarily rather than be seen as competing alternatives.

  15. [Portfolios: a tool for the training and assessment of residents in dermatology, part 2].

    Science.gov (United States)

    Casanova, J M; Soria, X; Borrego, L; De Argila, D; Ribera, M; Pujol, R M

    2011-06-01

    A portfolio is a collection of material documenting reflection about practice. It contains documents (eg, case histories and questionnaires the resident has used), images, and video recordings that reveal that an individual has acquired the competencies needed for professional practice. This assessment tool simultaneously supports learning and provides evidence for certifying competence. The adoption of portfolio use by a dermatology department requires the support of both the training supervisor and the chief of department. The learning objectives defined by the National Board for Medical-Surgical Dermatology and Venereology must be taken into consideration so that ways to assess each objective can be included; this approach supports holistic ongoing education as well as the certification of competencies the resident finally achieves. Use of portfolios in medical residency training can improve on current assessment methods, which we believe lack precision. We propose that portfolios gradually begin to replace the resident's training log. We are currently developing an online software application that will facilitate the use of portfolios. 2010 Elsevier España, S.L. and AEDV. All rights reserved.

  16. Climate Change Impacts for the Conterminous USA. An Integrated Assessment. Part 5. Irrigated Agriculture and National Grain Crop Production

    Energy Technology Data Exchange (ETDEWEB)

    Thomson, A.M.; Rosenberg, N.J.; Izaurralde, R.C. [Joint Global Change Research Institute, 8400 Baltimore Avenue, Suite 201, College Park, MD, 20740 (United States); Brown, R.A. [Independent Project Analysis, 11150 Sunset Hills Road, Suite 300, Reston, VA, 20190 (United States)

    2005-03-01

    During this century global warming will lead to changes in global weather and climate, affecting many aspects of our environment. Agriculture is the sector of the United States economy most likely to be directly impacted by climatic changes. We have examined potential changes in dryland agriculture (Part 3) and in water resources necessary for crop production (Part 4) in response to a set of climate change scenarios. In this paper we assess to what extent, under these same scenarios, water supplies will be sufficient to meet the irrigation requirement of major grain crops in the US. In addition, we assess the overall impacts of changes in water supply on national grain production. We apply the 12 climate change scenarios described in Part 1 to the water resources and crop growth simulation models described in Part 2 for the conterminous United States. Drawing on data from Parts 3 and 4 we calculate what the aggregate national production would be in those regions in which grain crops are currently produced by applying irrigation where needed and water supplies allow. The total amount of irrigation water applied to crops declines under all climate change scenarios employed in this study. Under certain of the scenarios and in particular regions, precipitation decreases so much that water supplies are too limited; in other regions precipitation becomes so plentiful that little value is derived from irrigation. Nationwide grain crop production is greater when irrigation is applied as needed. Under irrigation, less corn and soybeans are produced under most of the climate change scenarios than is produced under baseline climate conditions. Winter wheat production under irrigation responds significantly to elevated atmospheric carbon dioxide concentrations [CO2] and appears likely to increase under climate change.

  17. Plants and parts of plants used in food supplements: an approach to their safety assessment

    Directory of Open Access Journals (Sweden)

    Brunella Carratù

    2010-12-01

    Full Text Available In Italy most herbal products are sold as food supplements and are subject only to food law. A list of about 1200 plants authorised for use in food supplements has been compiled by the Italian ministry of Health. In order to review and possibly improve the ministry's list an ad hoc working group of Istituto Superiore di Sanità was requested to provide a technical and scientific opinion on plant safety. The listed plants were evaluated on the basis of their use in food, therapeutic activity, human toxicity and in no-alimentary fields. Toxicity was also assessed and plant limitations to use in food supplements were defined.

  18. Probabilistic evidential assessment of gunshot residue particle evidence (Part II): Bayesian parameter estimation for experimental count data.

    Science.gov (United States)

    Biedermann, A; Bozza, S; Taroni, F

    2011-03-20

    Part I of this series of articles focused on the construction of graphical probabilistic inference procedures, at various levels of detail, for assessing the evidential value of gunshot residue (GSR) particle evidence. The proposed models--in the form of Bayesian networks--address the issues of background presence of GSR particles, analytical performance (i.e., the efficiency of evidence searching and analysis procedures) and contamination. The use and practical implementation of Bayesian networks for case pre-assessment is also discussed. This paper, Part II, concentrates on Bayesian parameter estimation. This topic complements Part I in that it offers means for producing estimates usable for the numerical specification of the proposed probabilistic graphical models. Bayesian estimation procedures are given a primary focus of attention because they allow the scientist to combine (his/her) prior knowledge about the problem of interest with newly acquired experimental data. The present paper also considers further topics such as the sensitivity of the likelihood ratio due to uncertainty in parameters and the study of likelihood ratio values obtained for members of particular populations (e.g., individuals with or without exposure to GSR). Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  19. [Chemical speciation and risk assessment of heavy metals in the middle part of Yarlung Zangbo surface sediments].

    Science.gov (United States)

    Bai, Jian-kunt; Li, Chao-liu; Kang, Shi-chang; Chen, Peng-fei; Wang, Jian-li

    2014-09-01

    Nine heavy metals (Cd, Co, Ni, Cu, Zn, Pb, Cs, As, Cr) of surface sediments collected from the Middle Part of the Yarlung Zangbo River were analyzed by BCR sequential extraction procedure. Based on speciation distributions of these metals, ecological risk of heavy metals was assessed with methods of risk assessment code (RAC) and sediment quality guideline quotient (SQG-Q). The results show that: (1) Large part of Cr and As belong to residual fraction(87%-96%). Ni, Cu, Co and Cs have similar distribution characteristics (non-residual part accounts for approximate 20%). Correspondingly, mass fraction of Cd exists mainly in acid soluble and reducible faction (65% ) , indicating high ecological risk level. (2) Based on calculation of RAC method, Cd is of high risk to the environment (37. 38%). Accordingly, Co, Ni, Cu and Zn are of low risk, and Pb, Cs, As and Cr pose extreme low risk to the environment. According to evaluation of heavy metal speciation distributions, the potential ecological risk of heavy metals is in the descending order of Cd > Co > Ni > Cu > Zn > Pb > Cs > As > Cr. (3) The SQG index of sediments is 0. 804, indicating that studied river sediment has a moderate potential biological toxicity effect. Given most of heavy metals exists in residual fraction, the sediments of this region pose a low ecological risk to the environment.

  20. Aspectos da Reologia e da Estabilidade de Suspensões Cerâmicas. Parte III: Mecanismo de Estabilização Eletroestérica de Suspensões com Alumina Aspects of Rheology and Stability of Ceramic Suspensions. Part III: Electrosteric Stabilization Mechanism of Alumina Suspensions

    Directory of Open Access Journals (Sweden)

    F. S. Ortega

    1997-08-01

    Full Text Available Esta terceira e última parte da revisão sobre os aspectos reológicos e de estabilização de suspensões com pós cerâmicos vem reunir a aplicação dos conhecimentos adquiridos nas primeiras duas partes publicadas anteriormente. Aqui, os fenômenos eletrostático devido à dupla camada elétrica, e estérico, relacionado à adsorção de moléculas poliméricas, são combinados para explicar o mecanismo eletroestérico de estabilização de suspensões cerâmicas. Os defloculantes que atuam através desse mecanismo abrangem uma classe específica de polímero denominada polieletrólitos, a qual é constituída por macromoléculas ionizáveis quando em solução. O estudo da forma com que os polieletrólitos atuam justifica-se devido à larga utilização desta classe de polímeros na indústria cerâmica. Os ácidos poliacrílico (PAA e polimetacrílico (PMAA são exemplos de polieletrólitos amplamente utilizados no processo de materiais à base de alumina. Dá-se destaque à influência do pH do meio e da presença de íons, sendo novamente aqui importante o conceito de força iônica da suspensão. Como aplicação prática, apresenta-se a estabilidade do sistema alumina-PMAA, reportando-se sobre o comportamento da viscosidade e da efetiva defloculação da suspensão. Este estudo é concluído apresentando resultados do efeito do peso molecular sobre a viscosidade, chamando atenção para o fato de que não basta definir apenas a classe de polímero a ser usada, sendo também fundamental especificar o peso molecular médio do polímero selecionado.The third and last part of this review about stabilization and rheological aspects of ceramic suspension gathers the knowledge in the two parts previously published. Here, the electrostatic and steric phenomena, related to the electrical double layer and polymeric molecules adsorption, respectively, are combined to explain the electrosteric stabilization mechanism of ceramic suspensions. The

  1. Improving the Clinical Pharmacologic Assessment of Abuse Potential: Part 1: Regulatory Context and Risk Management.

    Science.gov (United States)

    Sellers, Edward M

    2018-02-01

    This article brings to the attention of drug developers the Food and Drug Administration's (FDA's) recent final Guidance to Industry on Assessment of Abuse Potential and provides practical suggestions about compliance with the Guidance. The Guidance areas are reviewed, analyzed, and placed in the context of current scientific knowledge and best practices to mitigate regulatory risk. The Guidance provides substantial new detail on what needs to be done at all stages of drug development for central nervous system-active drugs. However, because many psychopharmacologic agents have unique preclinical and clinical features, the plan for each agent needs to be not only carefully prepared but also reviewed and approved by the FDA. Examples are provided where assumptions about interpretation of the Guidance can delay development. If the expertise and experience needed for assessing abuse potential during drug development do not exist within a company, external preclinical and clinical expert should be involved. Consultation with the FDA is encouraged and important because the specific requirements for each drug will vary.

  2. Evaluation of triclosan in Minnesota lakes and rivers: Part II - human health risk assessment.

    Science.gov (United States)

    Yost, Lisa J; Barber, Timothy R; Gentry, P Robinan; Bock, Michael J; Lyndall, Jennifer L; Capdevielle, Marie C; Slezak, Brian P

    2017-08-01

    Triclosan, an antimicrobial compound found in consumer products, has been detected in low concentrations in Minnesota municipal wastewater treatment plant (WWTP) effluent. This assessment evaluates potential health risks for exposure of adults and children to triclosan in Minnesota surface water, sediments, and fish. Potential exposures via fish consumption are considered for recreational or subsistence-level consumers. This assessment uses two chronic oral toxicity benchmarks, which bracket other available toxicity values. The first benchmark is a lower bound on a benchmark dose associated with a 10% risk (BMDL10) of 47mg per kilogram per day (mg/kg-day) for kidney effects in hamsters. This value was identified as the most sensitive endpoint and species in a review by Rodricks et al. (2010) and is used herein to derive an estimated reference dose (RfD(Rodricks)) of 0.47mg/kg-day. The second benchmark is a reference dose (RfD) of 0.047mg/kg-day derived from a no observed adverse effect level (NOAEL) of 10mg/kg-day for hepatic and hematopoietic effects in mice (Minnesota Department of Health [MDH] 2014). Based on conservative assumptions regarding human exposures to triclosan, calculated risk estimates are far below levels of concern. These estimates are likely to overestimate risks for potential receptors, particularly because sample locations were generally biased towards known discharges (i.e., WWTP effluent). Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Model assessment of protective barriers: Part 3. Status of FY 1990 work

    Energy Technology Data Exchange (ETDEWEB)

    Fayer, M.J.; Rockhold, M.L.; Holford, D.J.

    1992-02-01

    Radioactive waste exists at the US Department of Energy`s (DOE`s) Hanford Site in a variety of locations, including subsurface grout and tank farms, solid waste burial grounds, and contaminated soil sites. Some of these waste sites may need to be isolated from percolating water to minimize the potential for transport of the waste to the ground water, which eventually discharges to the Columbia River. Multilayer protective barriers have been proposed as a means of limiting the flow of water through the waste sites (DOE 1987). A multiyear research program [managed jointly by Pacific Northwest Laboratory (PNL) and Westinghouse Hanford Company for the DOE] is aimed at assessing the performance of these barriers. One aspect of this program involves the use of computer models to predict barrier performance. Three modeling studies have already been conducted and a test plan was produced. The simulation work reported here was conducted by PNL and extends the previous modeling work. The purpose of this report are to understand phenomena that have been observed in the field and to provide information that can be used to improve hydrologic modeling of the protective barrier. An improved modeling capability results in better estimates of barrier performance. Better estimates can be used to improve the design of barriers and the assessment of their long-term performance.

  4. Accounting for ecosystem services in life cycle assessment, Part I: a critical review.

    Science.gov (United States)

    Zhang, Yi; Singh, Shweta; Bakshi, Bhavik R

    2010-04-01

    If life cycle oriented methods are to encourage sustainable development, they must account for the role of ecosystem goods and services, since these form the basis of planetary activities and human well-being. This article reviews methods that are relevant to accounting for the role of nature and that could be integrated into life cycle oriented approaches. These include methods developed by ecologists for quantifying ecosystem services, by ecological economists for monetary valuation, and life cycle methods such as conventional life cycle assessment, thermodynamic methods for resource accounting such as exergy and emergy analysis, variations of the ecological footprint approach, and human appropriation of net primary productivity. Each approach has its strengths: economic methods are able to quantify the value of cultural services; LCA considers emissions and assesses their impact; emergy accounts for supporting services in terms of cumulative exergy; and ecological footprint is intuitively appealing and considers biocapacity. However, no method is able to consider all the ecosystem services, often due to the desire to aggregate all resources in terms of a single unit. This review shows that comprehensive accounting for ecosystem services in LCA requires greater integration among existing methods, hierarchical schemes for interpreting results via multiple levels of aggregation, and greater understanding of the role of ecosystems in supporting human activities. These present many research opportunities that must be addressed to meet the challenges of sustainability.

  5. Bibliographical database of radiation biological dosimetry and risk assessment: Part 1, through June 1988

    Energy Technology Data Exchange (ETDEWEB)

    Straume, T.; Ricker, Y.; Thut, M.

    1988-08-29

    This database was constructed to support research in radiation biological dosimetry and risk assessment. Relevant publications were identified through detailed searches of national and international electronic databases and through our personal knowledge of the subject. Publications were numbered and key worded, and referenced in an electronic data-retrieval system that permits quick access through computerized searches on publication number, authors, key words, title, year, and journal name. Photocopies of all publications contained in the database are maintained in a file that is numerically arranged by citation number. This report of the database is provided as a useful reference and overview. It should be emphasized that the database will grow as new citations are added to it. With that in mind, we arranged this report in order of ascending citation number so that follow-up reports will simply extend this document. The database cite 1212 publications. Publications are from 119 different scientific journals, 27 of these journals are cited at least 5 times. It also contains reference to 42 books and published symposia, and 129 reports. Information relevant to radiation biological dosimetry and risk assessment is widely distributed among the scientific literature, although a few journals clearly dominate. The four journals publishing the largest number of relevant papers are Health Physics, Mutation Research, Radiation Research, and International Journal of Radiation Biology. Publications in Health Physics make up almost 10% of the current database.

  6. Assessment of possible airborne impact from nuclear risk sites - Part I: methodology for probabilistic atmospheric studies

    Science.gov (United States)

    Baklanov, A. A.; Mahura, A. G.

    2003-10-01

    The main purpose of this study is to develop a methodology for a multidisciplinary nuclear risk and vulnerability assessment, and to test this methodology through estimation of a nuclear risk to population in the Northern European countries in case of a severe accident at the nuclear risk sites. For assessment of the probabilistic risk and vulnerability, a combination of social-geophysical factors and probabilities are considered. The main focus of this paper is the description of methodology for evaluation of the atmospheric transport of radioactive releases from the risk site regions. The suggested methodology is given from the probabilistic point of view. The main questions stated are: What are probabilities and times for radionuclide atmospheric transport to different neighbouring countries and territories in case of the hypothetical accidental release at the nuclear risk site? Which geographical territories or countries are at the highest risk from the hypothetical accidental releases? To answer this question we suggest applying the following research tools for probabilistic atmospheric studies. First, it is atmospheric modelling to calculate multiyear forward trajectories originated over the sites. Second, it is statistical analysis tools to explore temporal and spatial structure of calculated trajectories in order to evaluate different probabilistic impact indicators: atmospheric transport pathways, airflow, fast transport, typical transport time, maximum possible impact zone, maximum reaching distance, etc. These indicators are applicable for further GIS-analysis and integration to estimate regional risk and vulnerability in case of accidental releases at the risk sites and for planning the emergency response and preparedness systems.

  7. Crustal Models Assessment in Western Part of Romania Employing Active Seismic and Seismologic Methods

    Science.gov (United States)

    Bala, Andrei; Toma-Danila, Dragos; Tataru, Dragos; Grecu, Bogdan

    2017-12-01

    In the years 1999 - 2000 two regional seismic refraction lines were performed within a close cooperation with German partners from University of Karlsruhe. One of these lines is Vrancea 2001, with 420 km in length, almost half of them recorded in Transylvanian Basin. The structure of the crust along the seismic line revealed a very complicated crustal structure beginning with Eastern Carpathians and continuing in the Transylvanian Basin until Medias. As a result of the development of the National Seismic Network in the last ten years, more than 100 permanent broadband stations are now continuously operating in Romania. Complementary to this national dataset, maintained and developed in the National Institute for Earth Physics, new data emerged from the temporary seismologic networks established during the joint projects with European partners in the last decades. The data gathered so far is valuable both for seismology purposes and crustal structure studies, especially for the western part of the country, where this kind of data were sparse until now. Between 2009 and 2011, a new reference model for the Earth’s crust and mantle of the European Plate was defined through the NERIES project from existing data and models. The database gathered from different kind of measurements in Transylvanian Basin and eastern Pannonian Basin were included in this NERIES model and an improved and upgraded model of the Earth crust emerged for western part of Romania. Although the dataset has its origins in several periods over the last 50 years, the results are homogeneous and they improve and strengthen our image about the depth of the principal boundaries in the crust. In the last chapter two maps regarding these boundaries are constructed, one for mid-crustal boundary and one for Moho. They were build considering all the punctual information available from different sources in active seismic and seismology which are introduced in the general maps from the NERIES project for

  8. ARFI ultrasound for in vivo hemostasis assessment postcardiac catheterization, part II: pilot clinical results.

    Science.gov (United States)

    Behler, Russell H; Scola, Mallory R; Nichols, Timothy C; Caughey, Melissa C; Fisher, Melrose W; Zhu, Hongtu; Gallippi, Caterina M

    2009-07-01

    In this second of a two part series, we present pilot clinical data demonstrating Acoustic Radiation Force Impulse (ARFI) ultrasound for monitoring the onset of subcutaneous hemostasis at femoral artery puncture sites (arteriotomies), in vivo. We conducted a randomized, reader-blinded investigation of 20 patient volunteers who underwent diagnostic percutaneous coronary catheterization. After sheath removal (6 French), patients were randomized to treatment with either standard of care manual compression alone or, to expedite hemostasis, manual compression augmented with a p-GlcNAc fiber-based hemostatic dressing (Marine Polymer Technologies, Danvers MA). Concurrent with manual compression, serial ARFI imaging began at the time of sheath removal and continued every minute for 15 min. Serial data sets were processed with custom software to (1) estimate the time of hemostasis onset, and (2) render hybrid ARFI/B-Mode images to highlight displacements considered to correspond to extravasted blood. Images were read by an observer blinded to the treatment groups. Average estimated times to hemostasis in patient volunteers treated with manual compression alone (n = 10) and manual compression augmented by hemostatic dressing (n = 9) were, respectively, 13.00 +/- 1.56 and 9.44 +/- 3.09 min, which are statistically significantly different (p = 0.0065, Wilcoxon two-sample test). Example images are shown for three selected patient volunteers. These pilot data suggest that ARFI ultrasound is relevant to monitoring subcutaneous bleeding from femoral arteriotomies clinically and that time to hemostasis was significantly reduced by use of the hemostatic dressing.

  9. Drifting buoy and other data as part of the Outer Continental Drifting buoy and other data as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 04 June 1976 to 01 October 1976 (NODC Accession 7700020)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Drifting buoy and other data was collected by the University of Washington (UW) as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP)....

  10. A national survey of medical risk assessment instruction in general practice residency programs (Part I).

    Science.gov (United States)

    Napholz, L; Kelly, W H

    1992-01-01

    Formal and structured training in medical risk assessment (MRA) has been a requirement in general practice residency (GPR) programs since their inception in 1972. Institutions offering GPR programs frequently differ in the levels and types of available resources necessary to implement this training. Program directors have expressed significant concerns that this training is difficult to provide, especially in the area of physical examination. The literature has not yet established how or if programs have organized their curricula to conform to accreditation standards in MRA established by the American Dental Association's Commission on Dental Accreditation. The purpose of this study was to conduct a nationwide survey of all GPR programs to identify program characteristics and resources, didactic and clinical educational methods, and perceived achievement of ADA Standard Fourteen for MRA training. Recommendations for further research are also given. Results will be reported in this paper, the paper following in this issue, and an additional paper to be published in a forthcoming issue.

  11. Core stabilization exercise prescription, part I: current concepts in assessment and intervention.

    Science.gov (United States)

    Brumitt, Jason; Matheson, J W; Meira, Erik P

    2013-11-01

    Injury to the low back can cause significant pain and dysfunction, which can affect an athlete's performance and result in time lost from sport. A common conservative treatment is therapeutic core stabilization exercises, which can address pain and musculoskeletal dysfunction in patients with low back pathology. MEDLINE and CINAHL were searched (from 1966 to March 2013) to identify relevant research. Keywords and keyword combinations searched included motor control exercise, segmental stabilization, core stabilization, transversus abdominis, multifidi, and low back pain. There are 2 popular rehabilitation strategies to assess core function and promote core stabilization. Each has been developed based on biomechanical models of lumbar segmental stability and observed motor control dysfunction in patients with low back pain. Controversy exists among clinical and research groups as to the optimal strategy for an athlete with low back pain.

  12. Why patients take part in the Royal College of Physicians Practical Assessment of Clinical Examination Skills (MRCP PACES).

    Science.gov (United States)

    McFarland, Lorraine; Barlow, Julie; Nwokolo, Chuka

    2012-02-01

    The aim of this study was to examine patients' motivation to participate in the Royal College of Physicians Practical Assessment of Clinical Examination Skills (PACES). An exploratory cross-sectional study was performed with data collected via telephone interviews. All patients aged 18+ who participated in PACES at University Hospitals Coventry and Warwickshire in the last two years were invited to take part; 28 patients were interviewed. Data were analysed using thematic content analysis. Motivational factors identified included the opportunity to give something back for the care received, contributing to doctors' learning processes, altruism and being able to learn more about one's own condition. Patients believed that they offered real-life experiences that cannot be provided by actors. The social environment during PACES played a large part in volunteer retention. Recruitment of patient volunteers needs to emphasise the altruistic nature of the role in assisting the learning process for doctors and the subsequent benefit for future patients.

  13. Assessment of mental health in adults of the northern part of the city of Kosovska Mitrovica

    Directory of Open Access Journals (Sweden)

    Mirković Momčilo

    2012-01-01

    Full Text Available Background/Aim. Mental health disorders lead to disorder of effective functioning of people and deterioration of quality of life. Early detection of individuals at risk of mental health disorders is extremely important from the aspect of mental health disorders prevention. The aim of the research was to determine the frequency of mental health problems among adult residents of northern Kosovska Mitrovica and to examine the association between frequency of mental health problems and socio-demographic and other characteristics of the population obtained by the questionnaire. Methods. The cross-sectional study on the representative sample of adult residents of northern Kosovska Mitrovica was performed in October 2009. To obtain information about the characteristics of mental health the Goldberg’s General Health Questionnaire (GHQ-28 was used. For performing survey at site the method of rapid epidemiological assessment was chosen. Statistical analysis included the methods of descriptive statistics, multivariate regression analysis and calculation of the Cronbach’s alpha coefficient of internal consistency of the questionnaire. Results. Mental health problems (total score were present in almost half of the respondents (49.2%. Psychosomatic problems were present in more than half of the respondents (55.4%, while anxiety and insomnia were present in almost half of the respondents (49.2%. Social dysfunction had more than three fifths of the respondents (63.1% and depression more than a quarter of the respondents (28.5%. More positive responses in the questionnaire were statistically significantly associated with older age, poor financial situation, abuse and assessing of the current political-security situation as high risk. The value of Cronbach’s alpha coefficient was 0.705. Conclusions. Almost half of the respondents (49.2% of North Kosovska Mitrovica had mental health problems. Mental health problems were associated with older age, poor

  14. Life-Cycle Assessment of Energy and Environmental Impacts of LED Lighting Products, Part 3: LED Environmental Testing

    Energy Technology Data Exchange (ETDEWEB)

    Tuenge, Jason R.; Hollomon, Brad; Dillon, Heather E.; Snowden-Swan, Lesley J.

    2013-03-01

    This report covers the third part of a larger U.S. Department of Energy (DOE) project to assess the life-cycle environmental and resource impacts in the manufacturing, transport, use, and disposal of light-emitting diode (LED) lighting products in relation to incumbent lighting technologies. All three reports are available on the DOE website (www.ssl.energy.gov/tech_reports.html). • Part 1: Review of the Life-Cycle Energy Consumption of Incandescent, Compact Fluorescent and LED Lamps; • Part 2: LED Manufacturing and Performance; • Part 3: LED Environmental Testing. Parts 1 and 2 were published in February and June 2012, respectively. The Part 1 report included a summary of the life-cycle assessment (LCA) process and methodology, provided a literature review of more than 25 existing LCA studies of various lamp types, and performed a meta-analysis comparing LED lamps with incandescent and compact fluorescent lamps (CFLs). Drawing from the Part 1 findings, Part 2 performed a more detailed assessment of the LED manufacturing process and used these findings to provide a comparative LCA taking into consideration a wider range of environmental impacts. Both reports concluded that the life-cycle environmental impact of a given lamp is dominated by the energy used during lamp operation—the upstream generation of electricity drives the total environmental footprint of the product. However, a more detailed understanding of end-of-life disposal considerations for LED products has become increasingly important as their installation base has grown. The Part 3 study (reported herein) was undertaken to augment the LCA findings with chemical analysis of a variety of LED, CFL, and incandescent lamps using standard testing procedures. A total of 22 samples, representing 11 different models, were tested to determine whether any of 17 elements were present at levels exceeding California or Federal regulatory thresholds for hazardous waste. Key findings include: • The selected

  15. 78 FR 62417 - Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy...

    Science.gov (United States)

    2013-10-22

    ... Part 324 RIN 3064-AD95 Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III... Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy, Transition Provisions...

  16. Assessing edge cracking resistance in AHSS automotive parts by the Essential Work of Fracture methodology

    Science.gov (United States)

    Frómeta, D.; Tedesco, M.; Calvo, J.; Lara, A.; Molas, S.; Casellas, D.

    2017-09-01

    Lightweight designs and demanding safety requirements in automotive industry are increasingly promoting the use of Advanced High Strength Steel (AHSS) sheets. Such steels present higher strength (above 800 MPa) but lower ductility than conventional steels. Their great properties allow the reduction of the thickness of automobile structural components without compromising the safety, but also introduce new challenges to parts manufacturers. The fabrication of most cold formed components starts from shear cut blanks and, due to the lower ductility of AHSS, edge cracking problems can appear during forming operations, forcing the stop of the production and slowing down the industrial process. Forming Limit Diagrams (FLD) and FEM simulations are very useful tools to predict fracture problems in zones with high localized strain, but they are not able to predict edge cracking. It has been observed that the fracture toughness, measured through the Essential Work of Fracture (EWF) methodology, is a good indicator of the stretch flangeability in AHSS and can help to foresee this type of fractures. In this work, a serial production automotive component has been studied. The component showed cracks in some flanged edges when using a dual phase steel. It is shown that the conventional approach to explain formability, based on tensile tests and FLD, fails in the prediction of edge cracking. A new approach, based on fracture mechanics, help to solve the problem by selecting steel grades with higher fracture toughness, measured by means of EWF. Results confirmed that fracture toughness, in terms of EWF, can be readily used as a material parameter to rationalize cracking related problems and select AHSS with improved edge cracking resistance.

  17. Direct and indirect drift assessment means. Part 1: PDPA laser based droplet characterisation.

    Science.gov (United States)

    Nuyttens, D; Baetens, K; De Schampheleire, M; Dekeyser, D; Sonck, B

    2008-01-01

    The spray quality generated by agricultural nozzles is important considering the efficiency of the pesticide application process because it affects spray deposits, biological efficacy and driftability. That is why a measuring set-up for the characterisation of spray nozzles was developed. This set-up is composed of a controlled climate room, a spray unit, a three-dimensional automated positioning system and an Aerometrics PDPA laser system which measures droplet size and velocity characteristics based on light scattering principles. Using this set-up and a well defined measuring protocol, droplet size and velocity characteristics of 15 different nozzle-pressure combinations were measured. It was found that at a nozzle distance of 0.50 m, droplet sizes vary from a few up to some hundreds of micrometres and droplet velocities from about 0 m.s(-1) up to 16 m.s(-1). From the results, the importance of the nozzle type and size on the droplet size and velocity spectra is clear. Standard flat fan nozzles produced the finest droplet size spectrum followed by low-drift and the air injection nozzles which results in significant differences in the proportion of small droplets. The larger the ISO nozzle size, the coarser is the droplet size spectrum and the lower is the proportion of small droplets. This effect is most pronounced for the standard flat fan followed by the low-drift nozzles and is less important for the air inclusion nozzles. Comparing the PDPA measuring results with other studies confirmed the need for reference nozzles to classify sprays because of the considerable variation of absolute results depending on variations in reference sprays, measuring protocol, measuring equipment and settings. As described in part 4, these results will be linked with the drift potential of different nozzle-pressure combinations.

  18. Portugal and United States cooperative energy assessment. Volume 3. Reference reports, Part 1

    Energy Technology Data Exchange (ETDEWEB)

    1981-09-01

    Statistical data on energy production and consumption and supporting information were obtained from US Bureau of Mines records supplemented by additional data obtained in Portugal. Geologic descriptions and analysis of known areas and of areas having possible future potential have been prepared by the US Geological Survey. Portugal lacks sufficient indigenous supplies of organic fuels to meet its energy demands, and so must import large quantities of petroleum and coal. Approximately 80% of Portugal's electric energy is produced by hydroelectric stations; thermal stations produce the other 20%. Portugal has produced no crude oil, natural gas, or condensate; no resources or reserves in these categories are listed for Portugal in the 1976 World Energy Conference report. Until the last year or so (1980), no significant onshore petroleum exploration had been done in Portugal since 1963. Production of coal in Portugal has declined steadily to the present annual yield of about 200,000 metric tons. On the basis of estimates in only three coal fields, resources of coal of all ranks in Portugal total at least 76 million (10/sup 6/) metric tons. Uranium is mined near Viseu and Guarda in the northern part of Portugal; the Nisa mine in east-central Portugal will begin producing uranium ore in 1985 after installation of a processing plant. Portugal produced 95 metric tons of uranium oxide (U/sub 3/O/sub 8/) from ore stocks in each year from 1972 through 1974; production is assumed to have continued at the same rate since then. Geothermal energy has not been developed in mainland Portugal; however, hot springs that may have geothermal energy potential are known in the Minho district in the northwest. Geothermal energy resources exist in the Azores and a program of evaluation and exploration with technical assistance from the USGS is presently in progress there.

  19. Toxicological assessment of kretek cigarettes Part 4: mechanistic investigations, smoke chemistry and in vitro toxicity.

    Science.gov (United States)

    Roemer, E; Dempsey, R; Lawless-Pyne, J; Lukman, S; Evans, A Deger; Trelles-Sticken, E; Wittke, S; Schorp, M K

    2014-12-01

    The smoke chemistry and in vitro toxicity of mainstream smoke (MS) was investigated in American-blended cigarettes with or without the addition of 2.5%, 5% or 10% eugenol to the tobacco and in Indonesian-blended cigarettes with and without the addition of cloves, cloves extracted with hot ethanol, and extracted cloves replenished with eugenol or clove oil. The addition of eugenol reduced the concentration of nearly all toxicants measured in MS as well as the in vitro cytotoxicity of the gas/vapor phase. Reductions were also seen in bacterial mutagenicity of the total particulate matter (TPM) assessed by the Ames Assay. The addition of extracted cloves led to increases and decreases of toxicant concentrations in MS. Replenishment with eugenol or clove oil decreased the toxicant concentrations; with most smoke constituent concentrations reduced below the concentration found in tobacco-only cigarettes. Cytotoxicity of the TPM was not affected by the clove preparations. However, GVP cytotoxicity was reduced (untreated cloves showing the highest reductions). Mutagenicity of TPM was decreased by the clove preparations. Mechanisms for the reductions, (up to 40%), are most likely due to dilution effects by eugenol, changed burning characteristics of the tobacco, and free radical scavenging by eugenol. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Portable Diagnostics Technology Assessment for Space Missions. Part 1; General Technology Capabilities for NASA Exploration Missions

    Science.gov (United States)

    Nelson, Emily S.; Chait, Arnon

    2010-01-01

    The changes in the scope of NASA s mission in the coming decade are profound and demand nimble, yet insightful, responses. On-board clinical and environmental diagnostics must be available for both mid-term lunar and long-term Mars exploration missions in an environment marked by scarce resources. Miniaturization has become an obvious focus. Despite solid achievements in lab-based devices, broad-based, robust tools for application in the field are not yet on the market. The confluence of rapid, wide-ranging technology evolution and internal planning needs are the impetus behind this work. This report presents an analytical tool for the ongoing evaluation of promising technology platforms based on mission- and application-specific attributes. It is not meant to assess specific devices, but rather to provide objective guidelines for a rational down-select of general categories of technology platforms. In this study, we have employed our expertise in the microgravity operation of fluidic devices, laboratory diagnostics for space applications, and terrestrial research in biochip development. A rating of the current state of technology development is presented using the present tool. Two mission scenarios are also investigated: a 30-day lunar mission using proven, tested technology in 5 years; and a 2- to 3-year mission to Mars in 10 to 15 years.

  1. Assessment of case-based integrated learning as a part of dental curriculum reform

    Science.gov (United States)

    Nadershahi, Nader A.

    There has been a growing call for change in the management of dental education programs, and, in response to this call, the faculty and staff at the University of the Pacific Arthur A. Dugoni School of Dentistry developed the Pacific Dental Helix Curriculum management model. The first major component of this curriculum was the development of the Integrated Clinical Science Strand of the Helix focused on multidisciplinary and case-based andragogies. The mixed method research design was used to identify common aspects of Case-Based Learning and multi-disciplinary teaching through a qualitative analysis of curricular materials and to analyze their impact on selected student outcomes of pre and post-change through statistical analysis. The outcomes chosen for the quantitative portion were surrogate measures of National Board Scores and grade point averages to represent knowledge and skills. The overall analysis of the quantitative data shows negligible impact on the outcomes being measured. We know from the literature that active learning models motivate and engage students at a higher level in their learning and better prepare them to solve problems creatively versus a traditional educational model, so it is significant to see that there were no decreases in performance with a move to a more engaging curriculum. This study offers foundational information for future curriculum design, pedagogy, and assessment.

  2. Drinking Water Quality Assessment Studies for an Urbanized Part of the Nagpur District, Central India.

    Science.gov (United States)

    Varade, Abhay M; Yenkie, Rajshree; Shende, Rahul; Kodate, Jaya

    2014-01-01

    The water quality of Hingna area of Nagpur district, Central India was assessed for its suitability as drinking water. 22 water samples, representing both the surface and groundwater sources, were collected and analysed for different inorganic constituents by using the standard procedures. The result depicted abundance of major ions; Ca2+ > Mg2+ > Na+ > K+ = HCO3- > Cl- > SO4(2-) > NO3-. The concentrations of different elements in water were compared with the drinking water standards defined by World Health Organization (WHO). The hydro-chemical results reveal that most of the samples were within the desirable limits of the drinking water quality. However, few samples of the area, showed higher values of total dissolved solids (TDS), total hardness (TH), and magnesium (Mg) indicating their 'hard water type' nature and found to be unfit for the drinking purpose. Such poor water quality of these samples is found due to the combined effect of urbanization and industrial activities. The potential health risks associated with various water parameters have also been documented in this paper.

  3. Assessing and helping challenging students: Part One, Why do some students have difficulty learning?

    Science.gov (United States)

    Hendricson, William D; Kleffner, John H

    2002-01-01

    When students struggle with routine assignments and fall behind classmates, a busy teacher may pigeonhole them as slow, give up on them, or become frustrated from failed efforts to bring them up to speed. Well-intentioned efforts to help struggling students by providing repetitions of the same experiences may fail because the specific cause of the sub-par performance was not identified. Six potential causes of inadequate student performance can serve as a diagnostic framework to help teachers pinpoint why a student is struggling academically: 1) cognitive factors, including poorly integrated, compartmentalized information, poor metacognition that hinders the student's ability to monitor and self-correct performance, bona fide learning disabilities that require professional assessment and treatment, and sensory-perceptual difficulties that may hinder performance in certain health care disciplines; 2) ineffective study habits, which are more common among professional students than faculty realize; 3) an inadequate educational experience (unclear objectives, poorly organized instruction, absence of coaching and timely feedback) or a punitive environment in which students avoid approaching instructors for assistance; 4) distraction due to nonacademic issues such as social relationships, health of a spouse, or employment; 5) dysfunctional levels of defensiveness that hinder student-teacher communication; and 6) underlying medical conditions that may affect student attentiveness, motivation, energy, and emotional balance. The objective of this article is to help faculty recognize potential underlying causes of a student's learning problems. Strategies for helping the academically struggling student are also introduced for several of these etiologies.

  4. Assessing contaminant sensitivity of endangered and threatened aquatic species: Part I. Acute toxicity of five chemicals

    Science.gov (United States)

    Dwyer, F.J.; Mayer, F.L.; Sappington, L.C.; Buckler, D.R.; Bridges, C.M.; Greer, I.E.; Hardesty, D.K.; Henke, C.E.; Ingersoll, C.G.; Kunz, J.L.; Whites, D.W.; Augspurger, T.; Mount, D.R.; Hattala, K.; Neuderfer, G.N.

    2005-01-01

    Assessment of contaminant impacts to federally identified endangered, threatened and candidate, and state-identified endangered species (collectively referred to as "listed" species) requires understanding of a species' sensitivities to particular chemicals. The most direct approach would be to determine the sensitivity of a listed species to a particular contaminant or perturbation. An indirect approach for aquatic species would be application of toxicity data obtained from standard test procedures and species commonly used in laboratory toxicity tests. Common test species (fathead minnow, Pimephales promelas; sheepshead minnow, Cyprinodon variegatus; and rainbow trout, Oncorhynchus mykiss) and 17 listed or closely related species were tested in acute 96-hour water exposures with five chemicals (carbaryl, copper, 4-nonylphenol, pentachlorophenol, and permethrin) representing a broad range of toxic modes of action. No single species was the most sensitive to all chemicals. For the three standard test species evaluated, the rainbow trout was more sensitive than either the fathead minnow or sheepshead minnow and was equal to or more sensitive than listed and related species 81% of the time. To estimate an LC50 for a listed species, a factor of 0.63 can be applied to the geometric mean LC50 of rainbow trout toxicity data, and more conservative factors can be determined using variance estimates (0.46 based on 1 SD of the mean and 0.33 based on 2 SD of the mean). Additionally, a low- or no-acute effect concentration can be estimated by multiplying the respective LC50 by a factor of approximately 0.56, which supports the United States Environmental Protection Agency approach of multiplying the final acute value by 0.5 (division by 2). When captive or locally abundant populations of listed fish are available, consideration should be given to direct testing. When direct toxicity testing cannot be performed, approaches for developing protective measures using common test

  5. DISASTER RISK AND CAPACITIES ASSESSMENT IN THE NORTH-WEST PARTS OF RWANDA

    Directory of Open Access Journals (Sweden)

    J.ean Baptiste Nsengiyumva

    2014-01-01

    Full Text Available The Republic of Rwanda is located in the Great lakes region of the central Africa. This landlocked country has historically suffered from periodic natural and manmade disasters, mainly in the form of droughts, floods and landslides impacting the agrarian economy and the country’s efforts towards sustainable development and poverty reduction. Vulnerability to Periodic natural disasters is a long term concern. The study therefore aims at conducting an assessment of disaster risks, vulnerabilities and coping capacities in Burera, Nyabihu and Musanze Districts affected floods and landslides in order to put in place mitigation strategies for disaster risks. Different methods and techniques were used to conduct this study including interviews, questionnaires, focus group discussions, field visits and observations, GIS and remote sensing among others. The analysis comprised the disaggregation of the hazards’ characteristics including description of the hazard, Triggering factors, Frequency, seasonality, Duration, sectors affected, impacts, time of recovery, intensity of the hazard and others. In terms of vulnerability. The analysis comprised physical, environmental, social, institutional, economic, profile of the most vulnerable populations, differentiation of impacts, and level of vulnerabilities. The study results showed that the Disaster Risk reduction is very possible through a comprehensive risk management. There is also a big need to expand capacity building in terms of disaster management, risk mapping to reach cell and village levels, put in place and operationalize early warning systems or hydro-meteorological hazards and many others in order to minimize the disaster risks and where possible to transform them into opportunities. All disasters are not preventable but mitigation is always possible.

  6. Accounting for ecosystem services in Life Cycle Assessment, Part II: toward an ecologically based LCA.

    Science.gov (United States)

    Zhang, Yi; Baral, Anil; Bakshi, Bhavik R

    2010-04-01

    Despite the essential role of ecosystem goods and services in sustaining all human activities, they are often ignored in engineering decision making, even in methods that are meant to encourage sustainability. For example, conventional Life Cycle Assessment focuses on the impact of emissions and consumption of some resources. While aggregation and interpretation methods are quite advanced for emissions, similar methods for resources have been lagging, and most ignore the role of nature. Such oversight may even result in perverse decisions that encourage reliance on deteriorating ecosystem services. This article presents a step toward including the direct and indirect role of ecosystems in LCA, and a hierarchical scheme to interpret their contribution. The resulting Ecologically Based LCA (Eco-LCA) includes a large number of provisioning, regulating, and supporting ecosystem services as inputs to a life cycle model at the process or economy scale. These resources are represented in diverse physical units and may be compared via their mass, fuel value, industrial cumulative exergy consumption, or ecological cumulative exergy consumption or by normalization with total consumption of each resource or their availability. Such results at a fine scale provide insight about relative resource use and the risk and vulnerability to the loss of specific resources. Aggregate indicators are also defined to obtain indices such as renewability, efficiency, and return on investment. An Eco-LCA model of the 1997 economy is developed and made available via the web (www.resilience.osu.edu/ecolca). An illustrative example comparing paper and plastic cups provides insight into the features of the proposed approach. The need for further work in bridging the gap between knowledge about ecosystem services and their direct and indirect role in supporting human activities is discussed as an important area for future work.

  7. The assessment of EUMETSAT HSAF Snow Products for mountainuos areas in the eastern part of Turkey

    Science.gov (United States)

    Akyurek, Z.; Surer, S.; Beser, O.; Bolat, K.; Erturk, A. G.

    2012-04-01

    Monitoring the snow parameters (e.g. snow cover area, snow water equivalent) is a challenging work. Because of its natural physical properties, snow highly affects the evolution of weather from daily basis to climate on a longer time scale. The derivation of snow products over mountainous regions has been considered very challenging. This can be done by periodic and precise mapping of the snow cover. However inaccessibility and scarcity of the ground observations limit the snow cover mapping in the mountainous areas. Today, it is carried out operationally by means of optical satellite imagery and microwave radiometry. In retrieving the snow cover area from satellite images bring the problem of topographical variations within the footprint of satellite sensors and spatial and temporal variation of snow characteristics in the mountainous areas. Most of the global and regional operational snow products use generic algorithms for flat and mountainous areas. However the non-uniformity of the snow characteristics can only be modeled with different algorithms for mountain and flat areas. In this study the early findings of Satellite Application Facilities on Hydrology (H-SAF) project, which is financially supported by EUMETSAT, will be presented. Turkey is a part of the H-SAF project, both in product generation (eg. snow recognition, fractional snow cover and snow water equivalent) for mountainous regions for whole Europe, cal/val of satellite-derived snow products with ground observations and cal/val studies with hydrological modeling in the mountainous terrain of Europe. All the snow products are operational on a daily basis. For the snow recognition product (H10) for mountainous areas, spectral thresholding methods were applied on sub pixel scale of MSG-SEVIRI images. The different spectral characteristics of cloud, snow and land determined the structure of the algorithm and these characteristics were obtained from subjective classification of known snow cover features

  8. Mortality probability model III and simplified acute physiology score II: assessing their value in predicting length of stay and comparison to APACHE IV.

    Science.gov (United States)

    Vasilevskis, Eduard E; Kuzniewicz, Michael W; Cason, Brian A; Lane, Rondall K; Dean, Mitzi L; Clay, Ted; Rennie, Deborah J; Vittinghoff, Eric; Dudley, R Adams

    2009-07-01

    To develop and compare ICU length-of-stay (LOS) risk-adjustment models using three commonly used mortality or LOS prediction models. Between 2001 and 2004, we performed a retrospective, observational study of 11,295 ICU patients from 35 hospitals in the California Intensive Care Outcomes Project. We compared the accuracy of the following three LOS models: a recalibrated acute physiology and chronic health evaluation (APACHE) IV-LOS model; and models developed using risk factors in the mortality probability model III at zero hours (MPM(0)) and the simplified acute physiology score (SAPS) II mortality prediction model. We evaluated models by calculating the following: (1) grouped coefficients of determination; (2) differences between observed and predicted LOS across subgroups; and (3) intraclass correlations of observed/expected LOS ratios between models. The grouped coefficients of determination were APACHE IV with coefficients recalibrated to the LOS values of the study cohort (APACHE IVrecal) [R(2) = 0.422], mortality probability model III at zero hours (MPM(0) III) [R(2) = 0.279], and simplified acute physiology score (SAPS II) [R(2) = 0.008]. For each decile of predicted ICU LOS, the mean predicted LOS vs the observed LOS was significantly different (p APACHE IVrecal, MPM(0) III, and SAPS II, respectively. Plots of the predicted vs the observed LOS ratios of the hospitals revealed a threefold variation in LOS among hospitals with high model correlations. APACHE IV and MPM(0) III were more accurate than SAPS II for the prediction of ICU LOS. APACHE IV is the most accurate and best calibrated model. Although it is less accurate, MPM(0) III may be a reasonable option if the data collection burden or the treatment effect bias is a consideration.

  9. Factsheets for the (eco)toxicological risk assessment strategy of the National Institute for Public Health and the Environment (RIVM), Part III

    NARCIS (Netherlands)

    Luttik R; van Raaij MTM; SEC; SIR

    2003-01-01

    In het rapport worden 4 factsheets gepresenteerd voor de risicoschattingsmethoden van het Stoffen Expertise Centrum (SEC) en het Centrum voor Stoffen en Integrale Risicoschatting (SIR) van het Rijksinstituut voor Volksgezondheid en Milieu (RIVM). 2 Factsheets hebben betrekking op de

  10. Viability testing of material derived from Mycobacterium tuberculosis prior to removal from a Containment Level-III Laboratory as part of a Laboratory Risk Assessment Program

    Directory of Open Access Journals (Sweden)

    Kabani Amin M

    2005-01-01

    Full Text Available Abstract Background In the field of clinical mycobacteriology, Mycobacterium tuberculosis (MTB can be a difficult organism to manipulate due to the restrictive environment of a containment level 3 (CL3 laboratory. Tests for rapid diagnostic work involving smears and molecular methods do not require CL3 practices after the organism has been rendered non-viable. While it has been assumed that after organism deactivation these techniques can be performed outside of a CL3, no conclusive study has consistently confirmed that the organisms are noninfectious after the theoretical 'deactivation' steps. Previous studies have shown that initial steps (such as heating /chemical fixation may not consistently kill MTB organisms. Methods An inclusive viability study (n = 226 was undertaken to determine at which point handling of culture extraction materials does not necessitate a CL3 environment. Four different laboratory protocols tested for viability included: standard DNA extractions for IS6110 fingerprinting, crude DNA preparations for PCR by boiling and mechanical lysis, protein extractions, and smear preparations. For each protocol, laboratory staff planted a proportion of the resulting material to Bactec 12B medium that was observed for growth for 8 weeks. Results Of the 208 isolates initially tested, 21 samples grew within the 8-week period. Sixteen (7.7% of these yielded positive results for MTB that included samples of: deactivated culture resuspensions exposed to 80°C for 20 minutes, smear preparations and protein extractions. Test procedures were consequently modified and tested again (n = 18, resulting in 0% viability. Conclusions This study demonstrates that it cannot be assumed that conventional practices (i.e. smear preparation or extraction techniques render the organism non-viable. All methodologies, new and existing, should be examined by individual laboratories to validate the safe removal of material derived from MTB to the outside of a CL3 laboratory. This process is vital to establish in house biosafety-validated practices with the aim of protecting laboratory workers conducting these procedures.

  11. Optical noncontact roughness measurements for the assessment of stress and deformation in tubular metallic parts of auto seats

    Science.gov (United States)

    Costa, Manuel F. M.; Quierós de Melo, Francisco J.; Carneiro, Joaquim A. O.

    2009-06-01

    The structural and material behaviour of parts of automobile seats must be known as extensively as possible. In order to assess deformation and failure in lightweight metallic tubular structural parts of auto seats a pseudo-dynamic procedure, to be briefly described herein, was devised. The deformation of circular section tubes subjected to centred transversal force can be assessed by measuring strain or the bending of the tubes. Most frequently contact gauges are used in this process. The authors employed optical noncontact microtopographic inspection using the MICROTOP.06.MFC microtopographer developed at the Microtopography' laboratory of the Physics Department of the University of the Minho. The system will be briefly described as well as the inspection methodology used. Bending radius can me directly measured. For stronger deformations however bending radius measures becomes unreliable and full topographic inspection must be performed. Roughness statistical parameters can also be calculated. If the surface of the tubes in the area where maximum deformation is expected to occur (located by finite elements simulation models) is textured to a certain level of roughness, changes in the roughness values after deformation were expected to be measurable. A direct correlation between the deformation state/tension, strain and stress, and surface' roughness, in particular the average roughness, was found. Results will be presented and discussed.

  12. Assessing the status of glaciers in part of the Chandra basin, Himachal Himalaya: A multiparametric approach

    Science.gov (United States)

    Garg, Purushottam Kumar; Shukla, Aparna; Tiwari, Reet Kamal; Jasrotia, Avtar Singh

    2017-05-01

    This study investigates the change in multiple glacier parameters of three valley-type glaciers (Sakchum (SC), Chhota Shigri (CS), and Bara Shigri (BS)) located in Chandra basin, Himachal Himalaya, sharing the same climatic regime, and assesses the control of nonclimatic factors on wholesome glacier response. Multitemporal satellite remote sensing data from Landsat-TM/ETM/OLI (1993-2014), and Terra-ASTER (2002-2014) along with an SRTM digital elevation model were used for extraction of the glacier parameters. Results show that while SC and BS retreated (SC: 10.65 ± 2.52 m/y; BS: 15.51 ± 2.52 m/y) and lost area (SC: 0.49 ± 0.0032 km2, BS: 1.18 ± 0.0032 km2), the CS remained relatively stable (retreat rate: 4.06 ± 2.52 m/y, area loss: 0.19 ± 0.0032 km2) during 1993-2014. However, results of surface ice velocities (SIV) change (SC: 24.41%, CS: 21.60%, and BS: 28.49%) and surface elevation change (SC: - 1.22 m/y, CS: - 0.91 m/y and BS: - 1.21 m/y) suggest a comparable slowing down and surface lowering from 2002 to 2014. Debris cover also varied substantially (SC: 30.25%, CS: 11.96%, BS: 19.61%) on these glaciers. Results reveal that higher retreat/deglaciation of glaciers was associated with higher altitudinal range, slow SIV in lower ablation zones (LAZ), and glacier hypsometry. Debris cover on glaciers was found to be controlled by slope, higher deglaciation rates, higher SIV in the upper ablation zone (UAZ) coupled with lower SIV in LAZ and surface lowering. Glacier SIV was primarily governed by slope gradient, differential surface lowering, and size of accumulation zone (ACZ). The SIV results confirm the presence of stagnant zones in the lower ablations of SC (Glacier surface lowering seemed to be influenced by ice-flux, changing spatial distribution of debris cover, presence of supraglacial lakes, and ice cliffs bordering them. Melting around supraglacial lakes and backwasting of ice cliffs may be the prime reasons behind intense mass loss observed in the

  13. Whole effluent assessment of industrial wastewater for determination of bat compliance: Part 1: Paper manufacturing industry.

    Science.gov (United States)

    Gartiser, Stefan; Hafner, Christoph; Hercher, Christoph; Kronenberger-Schäfer, Kerstin; Paschke, Albrecht

    2010-05-01

    The applicability of the Whole Effluent Assessment concept for the proof of compliance with the "best available techniques" has been analysed with paper mill wastewater from Germany by considering its persistency (P), potentially bio-accumulative substances (B) and toxicity (T). Twenty wastewater samples from 13 paper mills using different types of cellulose fibres as raw materials have been tested in DIN or ISO standardised bioassays: the algae, daphnia, luminescent bacteria, duckweed (Lemna), fish-egg and umu tests with lowest ineffective dilution (LID) as test result. The potentially bio-accumulative substances (PBS) were determined by solid-phase microextraction and referred to the reference compound 2,3-dimethylnaphthalene. Usually, a primary chemical-physical treatment of the wastewater was followed by a single or multi-stage biological treatment. One indirectly discharged wastewater sample was pre-treated biologically in the Zahn-Wellens test before determining its ecotoxicity. No toxicity or genotoxicity at all was detected in the acute daphnia and fish egg as well as the umu assay. In the luminescent bacteria test, moderate toxicity (up to LIDlb=6) was observed. Wastewater of four paper mills demonstrated elevated or high algae toxicity (up to LIDA=128), which was in line with the results of the Lemna test, which mostly was less sensitive than the algae test (up to LIDDW=8). One indirectly discharged wastewater sample was biodegraded in the Zahn-Wellens test by 96% and was not toxic after this treatment. Low levels of PBS have been detected (median 3.27 mmol L(-1)). The colouration of the wastewater samples in the visible band did not correlate with algae toxicity and thus is not considered as its primary origin. Further analysis with a partial wastewater stream from thermomechanically produced groundwood pulp (TMP) revealed no algae or luminescent bacteria toxicity after pre-treatment of the sample in the Zahn-Wellens test (chemical oxygen demand

  14. A prática clínica baseada em evidências: parte III - avaliação crítica das informações de pesquisas clínicas Evidence based clinical practice: part III - critical appraisal of clinical research

    Directory of Open Access Journals (Sweden)

    Moacyr Roberto Cuce Nobre

    2004-12-01

    consistente quanto à adequação do desenho de estudo e ao controle dos vícios. Concluímos que se deve oferecer atualização metodológica aos profissionais interessados, e colocar a informação já avaliada à disposição de todos, elaborando e divulgando diretrizes baseadas em evidências.Evidence based health care begins with a clinical question and the search on data bases to retrieve the relevant information, that was the issue of two preceding articles of this series. At present it will be discussed how to critically appraise the medical literature using the clinical epidemiological methodology. Clinical research aims to develop diagnostic and therapeutic procedures measuring association and causality between the exposure and outcome. In this case the exposures are signs, symptoms, laboratorial or image exam, and therapy intervention. It is a mistake to take surrogate end-points instead of clinical outcomes. The main types of clinical study design are diagnostic, prognostic, therapeutic and harm/etiology. Experimental, physiologic and animal studies are useful for the medical undergraduate education, but do not contribute with clinical decisions. The study designs are classified according with the presence of a control group, patient's follow-up, and therapy interventions. The evidence hierarchy was done by the previous characteristics and the presence of systematic bias. Systematic reviews are stronger than the primary observational studies and are on the top when they revised randomized clinical trial. Since 1998 the proportion of evidence based practice guidelines was increasing compared with systematic reviews or other types of practice guidelines, although the former still are in a few numbers. The article critical appraisal must answer the clinical question, and need to have consistent study design and bias under control. In conclusion we ought to offer methodological actualization to interested physicians and put the information already critically assessed

  15. Applying Best Practices to Military Commercial-Derivative Aircraft Engine Sustainment: Assessment of Using Parts Manufacturer Approval (PMA) Parts and Designated Engineering Representative (DER) Repairs

    Science.gov (United States)

    2016-01-01

    Processes for PMA Parts and DER Repairs 71 as possible. Representatives from all companies reported strong man - agement support for their efforts and...and Designated Engineering Representative (DER) Repairs Mary E. Chenoweth, Michael Boito, Shawn McKay, Rianne Laureijs C O R P O R A T I O N Limited...representative (DER) repairs to decrease the cost of their aircraft engine maintenance. These parts and repairs are provided by third-party companies and

  16. Unmanned Aerial Systems as Part of a Multi-Component Assessment Strategy to Address Climate Change and Atmospheric Processes

    Science.gov (United States)

    Lange, Manfred; Vrekoussis, Mihalis; Sciare, Jean; Argyrides, Marios; Ioannou, Stelios; Keleshis, Christos

    2015-04-01

    Unmanned Aerial Systems (UAS) have been established as versatile tools for different applications, providing data and observations for atmospheric and Earth-Systems research. They offer an urgently needed link between in-situ ground based measurements and satellite remote sensing observations and are distinguished by significant versatility, flexibility and moderate operational costs. UAS have the proven potential to contribute to a multi-component assessment strategy that combines remote-sensing, numerical modelling and surface measurements in order to elucidate important atmospheric processes. This includes physical and chemical transformations related to ongoing climate change as well as issues linked to aerosol-cloud interactions and air quality. The distinct advantages offered by UAS comprise, to name but a few: (i) their ability to operate from altitudes of a few meters to up to a few kilometers; (ii) their capability to perform autonomously controlled missions, which provides for repeat-measurements to be carried out at precisely defined locations; (iii) their relative ease of operation, which enables flexible employment at short-term notice and (iv) the employment of more than one platform in stacked formation, which allows for unique, quasi-3D-observations of atmospheric properties and processes. These advantages are brought to bear in combining in-situ ground based observations and numerical modeling with UAS-based remote sensing in elucidating specific research questions that require both horizontally and vertically resolved measurements at high spatial and temporal resolutions. Employing numerical atmospheric modelling, UAS can provide survey information over spatially and temporally localized, focused areas of evolving atmospheric phenomena, as they become identified by the numerical models. Conversely, UAS observations offer urgently needed data for model verification and provide boundary conditions for numerical models. In this presentation, we will

  17. Back to the Future - Part 2. Post-mortem assessment and evolutionary role of the bio-medicolegal sciences.

    Science.gov (United States)

    Ferrara, Santo Davide; Cecchetto, Giovanni; Cecchi, Rossana; Favretto, Donata; Grabherr, Silke; Ishikawa, Takaki; Kondo, Toshikazu; Montisci, Massimo; Pfeiffer, Heidi; Bonati, Maurizio Rippa; Shokry, Dina; Vennemann, Marielle; Bajanowski, Thomas

    2017-07-01

    Part 2 of the review "Back to the Future" is dedicated to the evolutionary role of the bio-medicolegal sciences, reporting the historical profiles, the state of the art, and prospects for future development of the main related techniques and methods of the ancillary disciplines that have risen to the role of "autonomous" sciences, namely, Genetics and Genomics, Toxicology, Radiology, and Imaging, involved in historic synergy in the "post-mortem assessment," together with the mother discipline Legal Medicine, by way of its primary fundament, universally denominated as Forensic Pathology. The evolution of the scientific research and the increased accuracy of the various disciplines will be oriented towards the elaboration of an "algorithm," able to weigh the value of "evidence" placed at the disposal of the "justice system" as real truth and proof.

  18. Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation

    Directory of Open Access Journals (Sweden)

    E. N. Lipets

    2015-01-01

    Full Text Available Thrombosis is a fatal hemostatic disorders occurring in various conditions ranging from pregnancy and surgery to cancer, sepsis and heart attack. Despite the availability of different anticoagulants and accumulated clinical experience, proving their effectiveness, thrombosis remains a major cause of morbidity and mortality. This is largely due to the fact that conventional laboratory coagulation tests are not sufficiently sensitive to the hypercoagulable state, and they are difficult to use for assessing the risk of thrombosis. Specific molecular markers (D-dimers, fibrinopeptide, thrombin-antithrombin complex are more effective, but also have a large number of disadvantages. A possible solution is the use of integrated test, which simulate in vitro the majority of the physiological coagulation processes. In the first part of this paper the biochemical processes that cause the risk of thrombosis were discussed.

  19. A Hybrid Multi-Criteria Decision Model for Technological Innovation Capability Assessment: Research on Thai Automotive Parts Firms

    Directory of Open Access Journals (Sweden)

    Sumrit Detcharat

    2013-01-01

    Full Text Available The efficient appraisal of technological innovation capabilities (TICs of enterprises is an important factor to enhance competitiveness. This study aims to evaluate and rank TICs evaluation criteria in order to provide a practical insight of systematic analysis by gathering the qualified experts’ opinions combined with three methods of multi-criteria decision making approach. Firstly, Fuzzy Delphi method is used to screen TICs evaluation criteria from the recent published researches. Secondly, the Analytic Hierarchy Process is utilized to compute the relative important weights. Lastly, the VIKOR method is used to rank the enterprises based on TICs evaluation criteria. An empirical study is applied for Thai automotive parts firms to illustrate the proposed methods. This study found that the interaction between criteria is essential and influences TICs; furthermore, this ranking development of TICs assessment is also one of key management tools to simply facilitate and offer a new mindset for managements of other related industries.

  20. Balloon Borne Soundings of Water Vapor, Ozone and Temperature in the Upper Tropospheric and Lower Stratosphere as Part of the Second SAGE III Ozone Loss and Validation Experiment (SOLVE-2)

    Science.gov (United States)

    Voemel, Holger

    2004-01-01

    The main goal of our work was to provide in situ water vapor and ozone profiles in the upper troposphere and lower stratosphere as reference measurements for the validation of SAGE III water vapor and ozone retrievals. We used the NOAA/CMDL frost point hygrometer and ECC ozone sondes on small research balloons to provide continuous profiles between the surface and the mid stratosphere. The NOAA/CMDL frost point hygrometer is currently the only lightweight balloon borne instrument capable of measuring water vapor between the lower troposphere and middle stratosphere. The validation measurements were based in the arctic region of Scandinavia for northern hemisphere observations and in New Zealand for southern hemisphere observations and timed to coincide with overpasses of the SAGE III instrument. In addition to SAGE III validation we also tried to coordinate launches with other instruments and studied dehydration and transport processes in the Arctic stratospheric vortex.

  1. Life-Cycle Assessment of Energy and Environmental Impacts of LED Lighting Products Part 2: LED Manufacturing and Performance

    Energy Technology Data Exchange (ETDEWEB)

    Scholand, Michael; Dillon, Heather E.

    2012-05-01

    Part 2 of the project (this report) uses the conclusions from Part 1 as a point of departure to focus on two objectives: producing a more detailed and conservative assessment of the manufacturing process and providing a comparative LCA with other lighting products based on the improved manufacturing analysis and taking into consideration a wider range of environmental impacts. In this study, we first analyzed the manufacturing process for a white-light LED (based on a sapphire-substrate, blue-light, gallium-nitride LED pumping a yellow phosphor), to understand the impacts of the manufacturing process. We then conducted a comparative LCA, looking at the impacts associated with the Philips Master LEDbulb and comparing those to a CFL and an incandescent lamp. The comparison took into account the Philips Master LEDbulb as it is now in 2012 and then projected forward what it might be in 2017, accounting for some of the anticipated improvements in LED manufacturing, performance and driver electronics.

  2. Integrated assessment modeling of atmospheric pollutants in the Southern Appalachian Mountains. Part I: hourly and seasonal ozone.

    Science.gov (United States)

    Boylan, James W; Odman, Mehmet T; Wilkinson, James G; Russell, Armistead G; Doty, Kevin G; Norris, William B; McNider, Richard T

    2005-07-01

    Recently, a comprehensive air quality modeling system was developed as part of the Southern Appalachians Mountains Initiative (SAMI) with the ability to simulate meteorology, emissions, ozone, size- and composition-resolved particulate matter, and pollutant deposition fluxes. As part of SAMI, the RAMS/EMS-95/URM-1ATM modeling system was used to evaluate potential emission control strategies to reduce atmospheric pollutant levels at Class I areas located in the Southern Appalachians Mountains. This article discusses the details of the ozone model performance and the methodology that was used to scale discrete episodic pollutant levels to seasonal and annual averages. The daily mean normalized bias and error for 1-hr and 8-hr ozone were within U.S. Environment Protection Agency guidance criteria for urban-scale modeling. The model typically showed a systematic overestimation for low ozone levels and an underestimation for high levels. Because SAMI was primarily interested in simulating the growing season ozone levels in Class I areas, daily and seasonal cumulative ozone exposure, as characterized by the W126 index, were also evaluated. The daily ozone W126 performance was not as good as the hourly ozone performance; however, the seasonal ozone W126 scaled up from daily values was within 17% of the observations at two typical Class I areas of the SAMI region. The overall ozone performance of the model was deemed acceptable for the purposes of SAMI's assessment.

  3. Intertidal organism and habitat data as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 05 August 1975 to 07 September 1975 (NODC Accession 7700087)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Intertidal organism and habitat data were collected as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP). Data were collected by Western...

  4. Drifting buoy and other data as part of the Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 17 May 1976 to 23 December 1976 (NODC Accession 7800105)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Drifting buoy data was collected by the Atlantic Oceanographic and Meteorological Laboratory (AOML) as part of the Outer Continental Shelf Environmental Assessment...

  5. Intertidal organism and habitat data as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP) from 05 August 1975 to 07 September 1975 (NODC Accession 7700086)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Intertidal organism and habitat data were collected as part of Outer Continental Shelf Environmental Assessment Program (OCSEAP). Data were collected by Western...

  6. Workshop: Improving the Assessment and Valuation of Climate Change Impacts for Policy and Regulatory Analysis: Research on Climate Change Impacts and Associated Economic Damages (part 2)

    Science.gov (United States)

    This is a workshop titled Improving the Assessment and Valuation of Climate Change Impacts for Policy and Regulatory Analysis: Research on Climate Change Impacts and Associated Economic Damages (part 2)

  7. Antithrombin III blood test

    Science.gov (United States)

    ... medlineplus.gov/ency/article/003661.htm Antithrombin III blood test To use the sharing features on this page, ... a protein that helps control blood clotting. A blood test can determine the amount of AT III present ...

  8. ISPD Cardiovascular and Metabolic Guidelines in Adult Peritoneal Dialysis Patients Part I - Assessment and Management of Various Cardiovascular Risk Factors.

    Science.gov (United States)

    Wang, Angela Yee Moon; Brimble, K Scott; Brunier, Gillian; Holt, Stephen G; Jha, Vivekanand; Johnson, David W; Kang, Shin-Wook; Kooman, Jeroen P; Lambie, Mark; McIntyre, Chris; Mehrotra, Rajnish; Pecoits-Filho, Roberto

    2015-01-01

    Cardiovascular disease contributes significantly to the adverse clinical outcomes of peritoneal dialysis (PD) patients. Numerous cardiovascular risk factors play important roles in the development of various cardiovascular complications. Of these, loss of residual renal function is regarded as one of the key cardiovascular risk factors and is associated with an increased mortality and cardiovascular death. It is also recognized that PD solutions may incur significant adverse metabolic effects in PD patients. The International Society for Peritoneal Dialysis (ISPD) commissioned a global workgroup in 2012 to formulate a series of recommendations regarding lifestyle modification, assessment and management of various cardiovascular risk factors, as well as management of the various cardiovascular complications including coronary artery disease, heart failure, arrhythmia (specifically atrial fibrillation), cerebrovascular disease, peripheral arterial disease and sudden cardiac death, to be published in 2 guideline documents. This publication forms the first part of the guideline documents and includes recommendations on assessment and management of various cardiovascular risk factors. The documents are intended to serve as a global clinical practice guideline for clinicians who look after PD patients. The ISPD workgroup also identifies areas where evidence is lacking and further research is needed. Copyright © 2015 International Society for Peritoneal Dialysis.

  9. 17 CFR Table III to Subpart E of... - Civil Monetary Penalty Inflation Adjustments

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Civil Monetary Penalty Inflation Adjustments III Table III to Subpart E of Part 201 Commodity and Securities Exchanges SECURITIES..., Table III Table III to Subpart E of Part 201—Civil Monetary Penalty Inflation Adjustments U.S. Code...

  10. A critical evaluation of subtalar joint arthrosis associated with middle facet talocalcaneal coalition in 21 surgically managed patients: a retrospective computed tomography review. Investigations involving middle facet coalitions-part III.

    Science.gov (United States)

    Kernbach, Klaus J; Barkan, Howard; Blitz, Neal M

    2010-01-01

    Symptomatic middle facet talocalcaneal coalition is frequently associated with rearfoot arthrosis that is often managed surgically with rearfoot fusion. However, no objective method for classifying the extent of subtalar joint arthrosis exists. No study has clearly identified the extent of posterior facet arthrosis present in a large cohort treated surgically for talocalcaneal coalition through preoperative computerized axial tomography. The authors conducted a retrospective review of 21 patients (35 feet) with coalition who were surgically treated over a 12-year period for coalition on at least 1 foot. Using a predefined original staging system, the extent of the arthrosis was categorized into normal or mild (Stage I), moderate (Stage II), and severe (Stage III) arthrosis. The association of stage and age is statistically significant. All of the feet with Stage III arthrosis had fibrous coalitions. No foot with osseous coalition had Stage III arthrosis. The distribution of arthrosis staging differs between fibrous and osseous coalitions. Only fibrous coalitions had the most advanced arthrosis (Stage III), whereas osseous coalitions did not. This suggests that osseous coalitions may have a protective effect in the prevention of severe degeneration of the subtalar joint. Concomitant subtalar joint arthrosis severity progresses with age; surgeons may want to consider earlier surgical intervention to prevent arthrosis progression in patients with symptomatic middle facet talocalcaneal coalition.

  11. Site specific risk assessment of an energy-from-waste thermal treatment facility in Durham Region, Ontario, Canada. Part A: Human health risk assessment.

    Science.gov (United States)

    Ollson, Christopher A; Knopper, Loren D; Whitfield Aslund, Melissa L; Jayasinghe, Ruwan

    2014-01-01

    The regions of Durham and York in Ontario, Canada have partnered to construct an energy-from-waste thermal treatment facility as part of a long term strategy for the management of their municipal solid waste. This paper presents the results of a comprehensive human health risk assessment for this facility. This assessment was based on extensive sampling of baseline environmental conditions (e.g., collection and analysis of air, soil, water, and biota samples) as well as detailed site specific modeling to predict facility-related emissions of 87 identified contaminants of potential concern. Emissions were estimated for both the approved initial operating design capacity of the facility (140,000 tonnes per year) and for the maximum design capacity (400,000 tonnes per year). For the 140,000 tonnes per year scenario, this assessment indicated that facility-related emissions are unlikely to cause adverse health risks to local residents, farmers, or other receptors (e.g., recreational users). For the 400,000 tonnes per year scenarios, slightly elevated risks were noted with respect to inhalation (hydrogen chloride) and infant consumption of breast milk (dioxins and furans), but only during predicted 'upset conditions' (i.e. facility start-up, shutdown, and loss of air pollution control) that represent unusual and/or transient occurrences. However, current provincial regulations require that additional environmental screening would be mandatory prior to expansion of the facility beyond the initial approved capacity (140,000 tonnes per year). Therefore, the potential risks due to upset conditions for the 400,000 tonnes per year scenario should be more closely investigated if future expansion is pursued. © 2013.

  12. Columnar modelling of nucleation burst evolution in the convective boundary layer – first results from a feasibility study Part III: Preliminary results on physicochemical model performance using two "clean air mass" reference scenarios

    Directory of Open Access Journals (Sweden)

    O. Hellmuth

    2006-01-01

    Full Text Available In Paper I of four papers, a revised columnar high-order model to investigate gas-aerosol-turbulence interactions in the convective boundary layer (CBL was proposed. In Paper II, the model capability to predict first-, second- and third-order moments of meteorological variables in the CBL was demonstrated using available observational data. In the present Paper III, the high-order modelling concept is extended to sulphur and ammonia chemistry as well as to aerosol dynamics. Based on the previous CBL simulation, a feasibility study is performed using two "clean air mass" scenarios with an emission source at the ground but low aerosol background concentration. Such scenarios synoptically correspond to the advection of fresh post-frontal air in an anthropogenically influenced region. The aim is to evaluate the time-height evolution of ultrafine condensation nuclei (UCNs and to elucidate the interactions between meteorological and physicochemical variables in a CBL column. The scenarios differ in the treatment of new particle formation (NPF, whereas homogeneous nucleation according to the classical nucleation theory (CNT is considered. The first scenario considers nucleation of a binary system consisting of water vapour and sulphuric acid (H2SO4 vapour, the second one nucleation of a ternary system additionally involving ammonia (NH3. Here, the two synthetic scenarios are discussed in detail, whereas special attention is payed to the role of turbulence in the formation of the typical UCN burst behaviour, that can often be observed in the surface layer. The intercomparison of the two scenarios reveals large differences in the evolution of the UCN number concentration in the surface layer as well as in the time-height cross-sections of first-order moments and double correlation terms. Although in both cases the occurrence of NPF bursts could be simulated, the burst characteristics and genesis of the bursts are completely different. It is demonstrated

  13. Columnar modelling of nucleation burst evolution in the convective boundary layer - first results from a feasibility study Part III: Preliminary results on physicochemical model performance using two "clean air mass" reference scenarios

    Science.gov (United States)

    Hellmuth, O.

    2006-09-01

    In Paper I of four papers, a revised columnar high-order model to investigate gas-aerosol-turbulence interactions in the convective boundary layer (CBL) was proposed. In Paper II, the model capability to predict first-, second- and third-order moments of meteorological variables in the CBL was demonstrated using available observational data. In the present Paper III, the high-order modelling concept is extended to sulphur and ammonia chemistry as well as to aerosol dynamics. Based on the previous CBL simulation, a feasibility study is performed using two "clean air mass" scenarios with an emission source at the ground but low aerosol background concentration. Such scenarios synoptically correspond to the advection of fresh post-frontal air in an anthropogenically influenced region. The aim is to evaluate the time-height evolution of ultrafine condensation nuclei (UCNs) and to elucidate the interactions between meteorological and physicochemical variables in a CBL column. The scenarios differ in the treatment of new particle formation (NPF), whereas homogeneous nucleation according to the classical nucleation theory (CNT) is considered. The first scenario considers nucleation of a binary system consisting of water vapour and sulphuric acid (H2SO4) vapour, the second one nucleation of a ternary system additionally involving ammonia (NH3). Here, the two synthetic scenarios are discussed in detail, whereas special attention is payed to the role of turbulence in the formation of the typical UCN burst behaviour, that can often be observed in the surface layer. The intercomparison of the two scenarios reveals large differences in the evolution of the UCN number concentration in the surface layer as well as in the time-height cross-sections of first-order moments and double correlation terms. Although in both cases the occurrence of NPF bursts could be simulated, the burst characteristics and genesis of the bursts are completely different. It is demonstrated, that

  14. Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy

    DEFF Research Database (Denmark)

    Karsdal, Morten A; Henriksen, Kim; Nielsen, Mette Juul

    2016-01-01

    trial of the glitazone farglitazar in patients with advanced hepatitis C, with matched follow-up liver biopsies, and from a phase III study of balaglitazone in patients with late-stage Type 2 diabetes (BALLET study) were analyzed for serological Pro-C3 levels in conjunction with other disease parameters....... In the farglitazar study, a predefined cutoff value for Pro-C3 as a selection criterion led to the identification of subjects who 1) progressed by histological scores and 2) responded to therapy, as documented by attenuated fibrosis in liver biopsies. In the BALLET trial, subjects with the highest tertile of Pro-C3...

  15. Sintassi e Tassonomia: Teoria della valenza e lessico-grammatica in tedesco e in italiano (III) (Syntax and Taxonomy: Theory of Valence and Lexical Grammar in German and Italian, Part 3).

    Science.gov (United States)

    Bianco, Maria Teresa

    1987-01-01

    In this article, the author concludes a three-part series in which she analyzes verb complements in German and Italian. Parts 1 and 2 of the series appear in volume 18, numbers 2 and 3, respectively. (CFM)

  16. Immunohistochemical assessment of collagen types I, III, IV and VI in biopsy samples of the bovine uterine wall collected during the oestrous cycle.

    Science.gov (United States)

    Boos, A

    2000-01-01

    Uterine biopsies were collected at cycle days 1 (oestrous), 8, 15 and 19 in six cows. Unfixed cryostat sections were used to immunolocalise collagen types I, III, IV and VI by an indirect FITC method. Collagen I was sparsely found in the endometrium where it formed a fine meshwork of thin fibres directly below the surface epithelium, clearly visible only at cycle days 8 and 15. Collagen III formed the bulk of connective tissue fibres and was arranged in fine aggregates within the superficial endometrial stroma, while in the deeper areas it consisted of many thick fibre bundles. Collagen IV was found in basement membranes underlying all endometrial epithelia. Furthermore, it surrounded smooth muscle cells of blood vessels. A few single fibrils also stained positively within the endometrial stroma, more numerous at cycle days 1 and 19 as compared to days 8 and 15. Collagen VI formed a mesh of fine and pericellularly situated fibrils within the endometrial stroma. The contribution of the collagen types studied to the connective tissue of caruncles, blood vessels, lymph follicles, and myometrium is also reported. The results of the present study indicate that the connective tissue of the bovine uterine wall is composed of different collagen types, which exhibit a characteristic distribution pattern each. The day of cycle may influence amounts and organisation of collagen types I and IV as demonstrated here at the light-microscopical level. Copyright 2000 S. Karger AG, Basel

  17. Assessing customs performance in the Mediterranean ports. KPI selection and Best practices identification as part of the MEDNET project

    Energy Technology Data Exchange (ETDEWEB)

    Morales Fusco, P.; Sauri Marchan, S.; Lekka, A.M.; Karousos, I.

    2016-07-01

    The seamless flow of goods, people and investments across the Mediterranean necessitates a well-functioning port and transport system. More efficient port operations enhance seamless logistics and promote safety, efficiency, interoperability and interconnectivity of transport networks in the Mediterranean area.To promote the exchange of knowledge and expertise relevant to port and customs procedures and simplification of clearance for vessels and cargoes in the Mediterranean, the MEDNET project was launched. As part of the project a common evaluation framework for the performance of ports in the form of a set of Key Performance Indicators (KPIs) together with a list of the best practices in terms of operations and customs procedures was developed.In total, 50 ports were analyzed and given a KPI regarding traffic, financial, operational and human resources, sustainability and customs procedures. The values were latter crossed with the current good practices on operation in terms of customs procedures. And a small correlation between KPIs performance and implantation degree of good practices in customs procedures was found. This presentation exposes the methodology to assess the ports’ performance and the best. (Author)

  18. A global water scarcity assessment under Shared Socio-economic Pathways – Part 2: Water availability and scarcity

    Directory of Open Access Journals (Sweden)

    N. Hanasaki

    2013-07-01

    Full Text Available A global water scarcity assessment for the 21st century was conducted under the latest socio-economic scenario for global change studies, namely Shared Socio-economic Pathways (SSPs. SSPs depict five global situations with substantially different socio-economic conditions. In the accompanying paper, a water use scenario compatible with the SSPs was developed. This scenario considers not only quantitative socio-economic factors such as population and electricity production but also qualitative ones such as the degree of technological change and overall environmental consciousness. In this paper, water availability and water scarcity were assessed using a global hydrological model called H08. H08 simulates both the natural water cycle and major human activities such as water abstraction and reservoir operation. It simulates water availability and use at daily time intervals at a spatial resolution of 0.5° × 0.5°. A series of global hydrological simulations were conducted under the SSPs, taking into account different climate policy options and the results of climate models. Water scarcity was assessed using an index termed the Cumulative Abstraction to Demand ratio, which is expressed as the accumulation of daily water abstraction from a river divided by the daily consumption-based potential water demand. This index can be used to express whether renewable water resources are available from rivers when required. The results suggested that by 2071–2100 the population living under severely water-stressed conditions for SSP1-5 will reach 2588–2793 × 106 (39–42% of total population, 3966–4298 × 106 (46–50%, 5334–5643 × 106 (52–55%, 3427–3786 × 106 (40–45%, 3164–3379 × 106 (46–49% respectively, if climate policies are not adopted. Even in SSP1 (the scenario with least change in water use and climate global water scarcity increases considerably, as compared to the present-day. This is mainly due to the growth in population

  19. A global water scarcity assessment under Shared Socio-economic Pathways - Part 2: Water availability and scarcity

    Science.gov (United States)

    Hanasaki, N.; Fujimori, S.; Yamamoto, T.; Yoshikawa, S.; Masaki, Y.; Hijioka, Y.; Kainuma, M.; Kanamori, Y.; Masui, T.; Takahashi, K.; Kanae, S.

    2013-07-01

    A global water scarcity assessment for the 21st century was conducted under the latest socio-economic scenario for global change studies, namely Shared Socio-economic Pathways (SSPs). SSPs depict five global situations with substantially different socio-economic conditions. In the accompanying paper, a water use scenario compatible with the SSPs was developed. This scenario considers not only quantitative socio-economic factors such as population and electricity production but also qualitative ones such as the degree of technological change and overall environmental consciousness. In this paper, water availability and water scarcity were assessed using a global hydrological model called H08. H08 simulates both the natural water cycle and major human activities such as water abstraction and reservoir operation. It simulates water availability and use at daily time intervals at a spatial resolution of 0.5° × 0.5°. A series of global hydrological simulations were conducted under the SSPs, taking into account different climate policy options and the results of climate models. Water scarcity was assessed using an index termed the Cumulative Abstraction to Demand ratio, which is expressed as the accumulation of daily water abstraction from a river divided by the daily consumption-based potential water demand. This index can be used to express whether renewable water resources are available from rivers when required. The results suggested that by 2071-2100 the population living under severely water-stressed conditions for SSP1-5 will reach 2588-2793 × 106 (39-42% of total population), 3966-4298 × 106 (46-50%), 5334-5643 × 106 (52-55%), 3427-3786 × 106 (40-45%), 3164-3379 × 106 (46-49%) respectively, if climate policies are not adopted. Even in SSP1 (the scenario with least change in water use and climate) global water scarcity increases considerably, as compared to the present-day. This is mainly due to the growth in population and economic activity in developing

  20. Assessment of the English literacy level of patients in primary health care services in Tshwane, Gauteng province: Part 2

    Directory of Open Access Journals (Sweden)

    Todd M. Maja

    2010-03-01

    ,naamlik die Learning Ability Battery (LAB en die aangepasde Rapid Estimate of Adult Literacy, Revised(REALM-R te assesseer. Daar is voorts ook bepaal hoe die resultate van die aangepaste REALM-R met die LAB korreleer. Data is deur self-rapportering ingesamel, waar die deelnemers vrae uit die LAB-instrument moes beantwoord en spesifieke woorde vir die aangepaste REALM-R hardop te lees. Die data is ontleed deur gebruik te maak van beskrywende en inferensiële statistiek, met inbegrip van ’n chikwadraat-toets en Spearman se rho. Die resultate dui daarop dat die skoolgraad bereik en die leesgeletterdheid van die deelnemers in Suid-Afrika met vier grade verskil. Die korrelasie tussen die resultate van die LAB en die aangepaste REALM-R was r = 0.43 (p < 0.001.Na gelang van die afsnypunt wat vir die aangepaste REALM-R gebruik word, dui die resultate daarop dat 67% van die deelnemers lae geletterdheidsvlakke het. Die studie toon die belang van ’n geldige, vinnige instrument vir geletterdheidsifting. Die doeltreffende assessering van pasiënte se geletterdheidsvlakke kan geregistreerde verpleegkundiges help om gesondheidsonderrig op ’n toepaslike vlak aan te bied ten einde pasiënte se gesondheidsgeletterdheid te verbeter.

    How to cite this article: Wasserman,Z.,Wright,S.C.D. & Maja,T.M.,2010, ‘Assessment of the English literacy level of patients in primary health care services in Tshwane,Gauteng Province: Part 2’,Health SA Gesondheid 15(1,Art. #469, 6 pages. DOI:10.4102/hsag.v15i1.469

  1. Perfis cognitivos de crianças e adolescentes com dislexia na WISC-III

    Directory of Open Access Journals (Sweden)

    Camila Cruz-Rodrigues

    2014-08-01

    Full Text Available Cognitive assessment in Development Dyslexia is of paramount important because it is a part of the diagnostic criteria and it can assist in the planning of effective interventions allowing to identify a profile of difficulties and facilities on the specific tasks. This aim of this study was to investigate the profile on the WISC-III. For such, 123 participants with developmental dyslexia were assessment. The age ranges from 8 to 14 years old, with 83 (67,5% boys and 40 (52,5% girls, belonging to private (52,8% and public (47,% schools. Clusters analysis showed 3 profiles according to WISC-III measures. ANOVA showed differences between all groups in the IQ measures and in majority of the subtests. No differences were found between groups in age and grade. Furthermore, there was a higher number of subjects in public schools in the group with lower performance in the WISC-III subtests.

  2. Perfis cognitivos de crianças e adolescentes com dislexia na WISC-III

    Directory of Open Access Journals (Sweden)

    Camila Cruz-Rodrigues

    2014-01-01

    Full Text Available Cognitive assessment in Development Dyslexia is of paramount important because it is a part of the diagnostic criteria and it can assist in the planning of effective inter - ventions allowing to identify a profile of difficulties and facilities on the specific tasks.This aim of this study was to investigate the profile on the WISC-III. For such, 123 participants with developmental dyslexia were assessment. The age ranges from 8 to 14 years old, with 83 (67,5% boys and 40 (52,5% girls, belonging to private (52,8% and public (47,% schools. Clusters analysis showed 3 profiles according to WISC-III measures. ANOVA showed differences between all groups in the IQ mea - sures and in majority of the subtests. No differences were found between groups in age and grade. Furthermore, there was a higher number of subjects in public schools in the group with lower performance in the WISC-III subtests.

  3. Assessment of metabolic syndrome in Kashmiri population with type 2 diabetes employing the standard criteria's given by WHO, NCEPATP III and IDF.

    Science.gov (United States)

    Lone, Shafat; Lone, Kouser; Khan, Saika; Pampori, Rafiq Ahmed

    2017-12-01

    Around 20-25 percent of the world's adult populations have the metabolic syndrome and they are twice as likely to die from heart attack or stroke compared with people without the syndrome. The World Health Organization proposed a definition for the metabolic syndrome in 1998 and later on NCEP ATPIII and IDF provided new definitions of this syndrome in 2001 and 2003 respectively. Very few studies have compared the different definitions to diagnose the metabolic syndrome in type two diabetics in India while as for Kashmir valley no such documented study has been carried out till date. To study the prevalence of metabolic syndrome in type 2 Kashmir diabetics and to find out the degree of agreement between three different criteria given by WHO, NCEPATPIII and IDF for diagnosis of metabolic syndrome. A cross sectional study was conducted in one of the two tertiary care hospitals of Kashmir, India. About 1000 patients were selected and their demographic, clinical and biochemical parameters were studied after obtaining informed consent from each patient. Prevalance of metabolic syndrome was found to be highest(84.5%) while using WHO definition.Kappa statistic between WHO, ATP III and WHO, IDF definitions was 0.697 (95% CI 0.637-0.754) and 0.775 (95%CI 0.72-0.82) respectively while the degree of agreement between IDF and ATP III definitions was highest with kappa of 0.851 (95%CI 0.810-0.889). Our study warrants for interventions to prevent the progression towards this syndrome among type 2 diabetics as early as the diagnosis of diabetes is made. Copyright © 2017 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

  4. Crescimento da base craniana nos diferentes tipos faciais nos relacionamentos maxilomandibulares ortopédicos de Classe I, II e III: Parte 2 (Crescimento médio de Ba-Na, CC-Na e CC-Ba Cranial base growth in different facial types in Class I, II and III orthopedic maxillomandibular relationship: Part 2 (Mean growth of Ba-Na, CC-Na and CC-Ba

    Directory of Open Access Journals (Sweden)

    Lucelma Vilela Pieri

    2007-04-01

    Full Text Available OBJETIVO: este estudo retrospectivo avaliou o crescimento médio da base craniana nos diferentes tipos faciais e de relacionamentos maxilomandibulares ortopédicos.METODOLOGIA: uma amostra aleatória de 300 pacientes brasileiros leucodermas (131 do gênero masculino, 169 do gênero feminino, com idade média inicial de 10 anos e 2 meses (dentadura mista e final de 14 anos e 8 meses (segundos molares em oclusão e tempo médio de observação de 4 anos e 5 meses, foi selecionada em uma clínica particular, em São Paulo, Brasil. Havia 118 Classe I, 151 Classe II e 31 Classe III. Todas as 600 radiografias cefalométricas laterais foram obtidas no mesmo aparelho de raios-x. As análises de Ricketts e Schwarz modificadas por Faltin foram usadas. As medidas lineares (Ba-Na, CC-Na e CC-Ba foram feitas manualmente pelo mesmo examinador em T1 e T2. Os relacionamentos foram estudados juntos e separadamente, considerando tipo facial e gênero. O teste t-pareado e ANOVA foram aplicados. RESULTADOS E CONCLUSÕES: o tipo facial retrovertido cresceu significantemente mais em CC-Na na Classe II, sendo a sua correção desfavorável no gênero feminino; com tendência favorável na Classe III e crescimento dentro do esperado na Classe I. O neutrovertido cresceu significantemente mais em CC-Na nas Classes I e II, sendo desfavorável na Classe II; com crescimento eqüitativo de CC-Na e CC-Ba na Classe III e levemente acima do esperado na Classe I. O provertido teve crescimento eqüitativo em todas as Classes, sendo significantemente favorável na Classe II mandibular; com tendência favorável na Classe III e crescimento médio acima do esperado na Classe I.AIM: This retrospective study evaluated the cranial base mean growth in different facial types and orthopedic maxillomandibular relationship. METHODS: A random sample of 300 Brazilian Caucasian patients (131 males, 169 females, initial and final mean age (10 years 2 months-mixed dentition; 14 years 8 months

  5. KULTURisk regional risk assessment methodology for water-related natural hazards - Part 2: Application to the Zurich case study

    Science.gov (United States)

    Ronco, P.; Bullo, M.; Torresan, S.; Critto, A.; Olschewski, R.; Zappa, M.; Marcomini, A.

    2015-03-01

    The aim of this paper is the application of the KULTURisk regional risk assessment (KR-RRA) methodology, presented in the companion paper (Part 1, Ronco et al., 2014), to the Sihl River basin, in northern Switzerland. Flood-related risks have been assessed for different receptors lying on the Sihl River valley including Zurich, which represents a typical case of river flooding in an urban area, by calibrating the methodology to the site-specific context and features. Risk maps and statistics have been developed using a 300-year return period scenario for six relevant targets exposed to flood risk: people; economic activities: buildings, infrastructure and agriculture; natural and semi-natural systems; and cultural heritage. Finally, the total risk index map has been produced to visualize the spatial pattern of flood risk within the target area and, therefore, to identify and rank areas and hotspots at risk by means of multi-criteria decision analysis (MCDA) tools. Through a tailored participatory approach, risk maps supplement the consideration of technical experts with the (essential) point of view of relevant stakeholders for the appraisal of the specific scores weighting for the different receptor-relative risks. The total risk maps obtained for the Sihl River case study are associated with the lower classes of risk. In general, higher (relative) risk scores are spatially concentrated in the deeply urbanized city centre and areas that lie just above to river course. Here, predicted injuries and potential fatalities are mainly due to high population density and to the presence of vulnerable people; flooded buildings are mainly classified as continuous and discontinuous urban fabric; flooded roads, pathways and railways, most of them in regards to the Zurich central station (Hauptbahnhof) are at high risk of inundation, causing severe indirect damage. Moreover, the risk pattern for agriculture, natural and semi-natural systems and cultural heritage is relatively

  6. The KULTURisk Regional Risk Assessment methodology for water-related natural hazards - Part 2: Application to the Zurich case study

    Science.gov (United States)

    Ronco, P.; Bullo, M.; Torresan, S.; Critto, A.; Olschewski, R.; Zappa, M.; Marcomini, A.

    2014-07-01

    The main objective of the paper is the application of the KULTURisk Regional Risk Assessment (KR-RRA) methodology, presented in the companion paper (Part 1, Ronco et al., 2014), to the Sihl River valley, in Switzerland. Through a tuning process of the methodology to the site-specific context and features, flood related risks have been assessed for different receptors lying on the Sihl River valley including the city of Zurich, which represents a typical case of river flooding in urban area. After characterizing the peculiarities of the specific case study, risk maps have been developed under a 300 years return period scenario (selected as baseline) for six identified relevant targets, exposed to flood risk in the Sihl valley, namely: people, economic activities (including buildings, infrastructures and agriculture), natural and semi-natural systems and cultural heritage. Finally, the total risk index map, which allows to identify and rank areas and hotspots at risk by means of Multi Criteria Decision Analysis tools, has been produced to visualize the spatial pattern of flood risk within the area of study. By means of a tailored participative approach, the total risk maps supplement the consideration of technical experts with the (essential) point of view of the relevant stakeholders for the appraisal of the specific scores and weights related to the receptor-relative risks. The total risk maps obtained for the Sihl River case study are associated with the lower classes of risk. In general, higher relative risks are concentrated in the deeply urbanized area within and around the Zurich city centre and areas that rely just behind to the Sihl River course. Here, forecasted injuries and potential fatalities are mainly due to high population density and high presence of old (vulnerable) people; inundated buildings are mainly classified as continuous and discontinuous urban fabric; flooded roads, pathways and railways, the majority of them referring to the Zurich main

  7. Selectivity of bis-triazinyl bipyridine ligands for americium(III) in Am/Eu separation by solvent extraction. Part 1. Quantum mechanical study on the structures of BTBP complexes and on the energy of the separation.

    Science.gov (United States)

    Narbutt, Jerzy; Oziminski, Wojciech P

    2012-12-21

    Theoretical studies were carried out on two pairs of americium and europium complexes formed by tetra-N-dentate lipophilic BTBP ligands, neutral [ML(NO(3))(3)] and cationic [ML(2)](3+) where M = Am(III) or Eu(III), and L = 6,6'-bis-(5,6-diethyl-1,2,4-triazin-3-yl)-2,2'-bipyridine (C2-BTBP). Molecular structures of the complexes have been optimized at the B3LYP/6-31G(d) level and total energies of the complexes in various media were estimated using single point calculations performed at the B3LYP/6-311G(d,p) and MP2/6-311G(d,p) levels of theory. In the calculations americium and europium ions were treated using pseudo-relativistic Stuttgart-Dresden effective core potentials and the accompanying basis sets. Selectivity in solvent extraction separation of two metal ions is a co-operative function of contributions from all extractable metal complexes, which depend on physico-chemical properties of each individual complex and on its relative amount in the system. Semi-quantitative analysis of BTBP selectivity in the Am/Eu separation process, based on the contributions from the two pairs of Am(III) and Eu(III) complexes, has been carried out. To calculate the energy of Am/Eu separation, a model of the extraction process was used, consisting of complex formation in water and transfer of the formed complex to the organic phase. Under the assumptions discussed in the paper, this simple two-step model results in reliable values of the calculated differences in the energy changes for each pair of the Am/Eu complexes in both steps of the process. The greater thermodynamic stability (in water) of the Am-BTBP complexes, as compared with the analogous Eu species, caused by greater covalency of the Am-N than Eu-N bonds, is most likely the main reason for BTBP selectivity in the separation of the two metal ions. The other potential reason, i.e. differences in lipophilic properties of the analogous complexes of Am and Eu, is less important with regard to this selectivity.

  8. Antithrombin III for critically ill patients

    DEFF Research Database (Denmark)

    Allingstrup, Mikkel; Wetterslev, Jørn; Ravn, Frederikke B

    2016-01-01

    PURPOSE: Antithrombin III (AT III) is an anticoagulant with anti-inflammatory properties. We assessed the benefits and harms of AT III in critically ill patients. METHODS: We searched from inception to 27 August 2015 in CENTRAL, MEDLINE, EMBASE, CAB, BIOSIS and CINAHL. We included randomized cont...

  9. Reactor safety study. An assessment of accident risks in U. S. commercial nuclear power plants. Appendices III and IV. [PWR and BWR

    Energy Technology Data Exchange (ETDEWEB)

    1975-10-01

    The items listed below summarize the detail sections which follow: a listing of definitions and a discussion of the general treatment of data within the random variable approach as utilized by the study; a tabulation of the assessed data base containing failure classifications, final assessed ranges utilized in quantification and reference source values considered in determining the ranges; a discussion of nuclear power plant experience that was used to validate the data assessment by testing its applicability as well as to check on the adequacy of the model to incorporate typical real incidents; an expanded presentation of the data assessment giving information on applicability considerations; a discussion of test and maintenance data including comparisons of models with experience data; and special topics, including assessments required for the initiating event probabilities and human error data and modeling.

  10. SIMONI (Smart Integrated Monitoring) as a novel bioanalytical strategy for water quality assessment: Part II-field feasibility survey.

    Science.gov (United States)

    van der Oost, Ron; Sileno, Giulia; Janse, Theo; Nguyen, Mai Thao; Besselink, Harrie; Brouwer, Abraham

    2017-09-01

    Because it is impossible to chemically analyze all relevant micropollutants, the implementation of bioanalytical tools is essential to estimate ecological risks of chemical mixtures in regular water-monitoring programs. The first tier of the Smart Integrated Monitoring (SIMONI) strategy, which was described in part I, is based on the combination of passive sampling and bioanalytical measurements. Bioassay responses are compared with effect-based trigger values (EBT), and an overall SIMONI score on all bioassay data was designed to indicate environmental risks. The present study is focused on analyzing the feasibility of the hazard identification tier by evaluating results of 45 field campaigns at sites with different pollution profiles near the city of Amsterdam. A Daphnia assay was performed in situ, while silicon rubber or polar organic chemical integrative sampler (POCIS) extracts were tested with 4 nonspecific (daphnids, algae, bacteria, and cell culture) and 10 specific (9 Chemical Activated Luciferase Gene Expression [CALUX] assays and antibiotics scan) bioassays. Sensitivity analyses demonstrated the relevance of 2 classification variables in the SIMONI score formula on all bioanalytical data. The model indicated increased risks for the ecosystem at surface waters in greenhouse areas and undiluted wastewater-treatment plant (WWTP) effluents. The choice of testing specific bioassays on either polar or nonpolar passive sampling extracts is cost-effective and still provided meaningful insights on micropollutant risks. Statistical analyses revealed that the model provides a relevant overall impact assessment based on bioassay responses. Data analyses on the chemically determined mixture toxic pressure and bioanalytical methods provided similar insights in relative risk ranking of water bodies. The SIMONI combination of passive sampling and bioanalytical testing appears to be a feasible strategy to identify chemical hazards. Environ Toxicol Chem 2017

  11. Assessing a narrated white board animation as part of the consent process for intravenous fluorescein angiography: a randomized educational study.

    Science.gov (United States)

    Mednick, Zale; Irrcher, Isabella; Hopman, Wilma M; Sharma, Sanjay

    2016-12-01

    To determine if a narrated white board animation (nWBA) video as part of the consent process for intravenous fluorescein angiography (IVFA) improves patient comprehension compared with a standard consent process. Prospective, randomized study. Patients undergoing an initial IVFA investigation. Three groups of 26 patients (N = 78) naïve to the IVFA procedure were included. Groups 1 and 2 consisted of patients undergoing IVFA for diagnostic purposes. Group 1 received the IVFA information via standard physician-patient interaction to obtain standard consent. Group 2 received IVFA information by watching an nWBA explaining the purpose, method, and risks of the diagnostic test to obtain informed consent. Group 3 comprised patients who were not scheduled to undergo IVFA. This group was exposed to both the standard and nWBA consent. All groups completed a 6-question knowledge quiz to assess retained information and a survey to reflect on the consent experience. Participants receiving information via standard physician-patient interaction to obtain informed consent had a lower mean knowledge score (4.38 out of 6; 73%) than participants receiving the information to obtain consent via nWBA (5.04 out of 6, 84%; P = 0.023). Of participants receiving both forms of information (group 3) to obtain informed consent, 73% preferred the nWBA to the standard consent process. Participants receiving consent information for an IVFA diagnostic test via nWBA have better knowledge retention regarding the IVFA procedure and preferred this medium compared with participants receiving the standard physician-patient interaction for obtaining consent. Incorporation of multimedia into the informed consent process should be explored for other diagnostic tests. Copyright © 2016 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  12. Sediment contamination in Lyons Creek East, a tributary of the Niagara River: part I. Assessment of benthic macroinvertebrates.

    Science.gov (United States)

    Milani, Danielle; Grapentine, Lee C; Fletcher, Rachael

    2013-01-01

    Sediments in Lyons Creek East (Welland, Ontario), a tributary of the Niagara River and part of the Niagara River Area of Concern, which exceed screening-level environmental-quality criteria for multiple contaminants, were assessed for biological impacts using information from multiple lines of evidence. An initial chemical survey indicated the primary contaminants of concern to be polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), zinc, and p,p'-DDE due to frequent exceedences of sediment guidelines. A subsequent study focused on the chemical composition of sediment, status of benthic invertebrate communities, contaminant bioaccumulation in resident benthos, and sediment toxicity to laboratory-exposed organisms. Chemical and biological conditions in the creek were compared with those in reference creeks using both multivariate (cluster analysis and ordination) and univariate (regression) techniques. Sediment PCBs (≤ 19 μg/g), PAHs (≤ 63 μg/g), and Zn (≤ 7969 μg/g) were increased above the sediment-quality guidelines along most of the creek; however, the upper 1.5 km portion of the creek was the most highly contaminated and therefore the main focus for biological study. Although severe toxicity was evident at several locations in the upper creek, resident benthic communities were minimally affected by sediment contamination. The cause of toxicity was likely related to a combination of stressors, including PCBs, PAHs, and metals. Due to its biomagnifiable nature, bioaccumulation focused on PCBs; concentrations in resident macroinvertebrates were ≤ 2 orders of magnitude greater than those found in reference creeks and were above tissue residue guidelines, indicating a potential risk for consumers of benthos. This risk was not limited to the upper 1.5 km where other effects were seen.

  13. Visible and near-infrared intense luminescence from water-soluble lanthanide [Tb(III), Eu(III), Sm(III), Dy(III), Pr(III), Ho(III), Yb(III), Nd(III), Er(III)] complexes.

    Science.gov (United States)

    Quici, Silvio; Cavazzini, Marco; Marzanni, Giovanni; Accorsi, Gianluca; Armaroli, Nicola; Ventura, Barbara; Barigelletti, Francesco

    2005-02-07

    The synthesis of a new ligand (1) containing a single phenanthroline (phen) chromophore and a flexibly connected diethylenetriamine tetracarboxylic acid unit (DTTA) as a lanthanide (Ln) coordination site is reported [1 is 4-[(9-methyl-1,10-phenantrol-2-yl)methyl]-1,4,7-triazaheptane-1,1,7,7-tetraacetic acid]. From 1, an extended series of water-soluble Ln.1 complexes was obtained, where Ln is Eu(III), Tb(III), Gd(III), Sm(III), Dy(III), Pr(III), Ho(III), Yb(III), Nd(III), and Er(III). The stoichiometry for the association was found 1:1, with an association constant K(A) > or = 10(7) s(-1) as determined by employing luminescence spectroscopy. The luminescence and photophysical properties of the series of lanthanide complexes were investigated in both H2O and D2O solutions. High efficiencies for the sensitized emission, phi(se), in air-equilibrated water were observed for the Ln.1 complexes of Eu(III) and Tb(III) in the visible region (phi(se) = 0.24 and 0.15, respectively) and of Sm(III), Dy(III), Pr(III), Ho(III), Yb(III), Nd(III), and Er(III) in the vis and/or near-infrared region [phi(se) = 2.5 x 10(-3), 5 x 10(-4), 3 x 10(-5), 2 x 10(-5), 2 x 10(-4), 4 x 10(-5), and (in D2O) 4 x 10(-5), respectively]. For Eu.1 and Tb.1, luminescence data for water and deuterated water allowed us to estimate that no solvent molecules (q) are bound to the ion centers (q = 0). Luminescence quenching by oxygen was investigated in selected cases.

  14. Nuclear Computerized Library for Assessing Reactor Reliability (NUCLARR): Data manual. Part 2: Human error probability (HEP) data; Volume 5, Revision 4

    Energy Technology Data Exchange (ETDEWEB)

    Reece, W.J.; Gilbert, B.G.; Richards, R.E. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1994-09-01

    This data manual contains a hard copy of the information in the Nuclear Computerized Library for Assessing Reactor Reliability (NUCLARR) Version 3.5 database, which is sponsored by the US Nuclear Regulatory Commission. NUCLARR was designed as a tool for risk analysis. Many of the nuclear reactors in the US and several outside the US are represented in the NUCLARR database. NUCLARR includes both human error probability estimates for workers at the plants and hardware failure data for nuclear reactor equipment. Aggregations of these data yield valuable reliability estimates for probabilistic risk assessments and human reliability analyses. The data manual is organized to permit manual searches of the information if the computerized version is not available. Originally, the manual was published in three parts. In this revision the introductory material located in the original Part 1 has been incorporated into the text of Parts 2 and 3. The user can now find introductory material either in the original Part 1, or in Parts 2 and 3 as revised. Part 2 contains the human error probability data, and Part 3, the hardware component reliability data.

  15. AND Dy(III)

    African Journals Online (AJOL)

    userpc

    SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL. ACTIVITIES OF Sm(III) AND Dy(III) COMPLEXES WITH SCHIFF BASE DERIVED FROM. 2-HYDROXY-1-NAPHTHALDEHYDE AND 2-AMINOBENZOIC ACID. 1Bashir, S.S. and Abdulhadi, A. 1Department of Chemistry, Rabi'u Musa Kwankwaso ...

  16. Transition metal complexes with thiosemicarbazide-based ligands. Part46. Synthesis and physico-chemical characterization of mixed ligand cobalt(III-complexes with salicylaldehyde semi-, thiosemi- and isothiosemicarbazone and pyridine

    Directory of Open Access Journals (Sweden)

    VUKADIN M. LEOVAC

    2003-12-01

    Full Text Available Mixed ligand octahedral cobalt(III complexes with the tridentate salicylaldehyde semi-, thiosemi- and isothiosemicarbazone and pyridine of general formula [CoIII(L11-3(py3]X (H2L1 = salicylaldehyde semicarbazone, X = [CoIICl3(py]-, ClO4- . H2O, I- . 0.5 I2; H2L2 = salicylaldehyde thiosemicarbazone, X = [CoIICl3(py]-, [CoIIBr3(py]-, ClO4- . H2O, I3-; H2L3 = salicylaldehyde S-methylisothiosemicarbazone, X = [ CoIIBr3(py ]-, ClO4- . H2O, BF4- were synthesized. The tridentate coordination of all the three dianionic forms of the ligands involves the phenol oxygen, hydrazine nitrogen and the chalcogen (O or S in case of salicylaldehyde semi-, thiosemicarbazone and the terminal nitrogen atom in the case of isothiosemicarbazone. For all the complexes, a meridial octahedral arrangement is proposed, which is a consequence of the planarity of the chelate ligand. The compounds were characterized by elemental analysis, molar conductivity, magnetic susceptibility, IR and electronic absorption spectra. The thermal decomposition of the complexes was investigated by thermogravimetry, coupled TG-MS measurements and DSC.

  17. EORTC QLQ-COMU26: a questionnaire for the assessment of communication between patients and professionals. Phase III of the module development in ten countries.

    Science.gov (United States)

    Arraras, Juan Ignacio; Wintner, Lisa M; Sztankay, Monika; Tomaszewski, Krzysztof A; Hofmeister, Dirk; Costantini, Anna; Bredart, Anne; Young, Teresa; Kuljanic, Karin; Tomaszewska, Iwona M; Kontogianni, Meropi; Chie, Wei-Chu; Kulis, Dagmara; Greimel, Eva

    2017-05-01

    Communication between patients and professionals is one major aspect of the support offered to cancer patients. The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) has developed a cancer-specific instrument for the measurement of different issues related to the communication between cancer patients and their health care professionals. Questionnaire development followed the EORTC QLG Module Development Guidelines. A provisional questionnaire was pre-tested (phase III) in a multicenter study within ten countries from five cultural areas (Northern and South Europe, UK, Poland and Taiwan). Patients from seven subgroups (before, during and after treatment, for localized and advanced disease each, plus palliative patients) were recruited. Structured interviews were conducted. Qualitative and quantitative analyses have been performed. One hundred forty patients were interviewed. Nine items were deleted and one shortened. Patients' comments had a key role in item selection. No item was deleted due to just quantitative criteria. Consistency was observed in patients' answers across cultural areas. The revised version of the module EORTC QLQ-COMU26 has 26 items, organized in 6 scales and 4 individual items. The EORTC COMU26 questionnaire can be used in daily clinical practice and research, in various patient groups from different cultures. The next step will be an international field test with a large heterogeneous group of cancer patients.

  18. Sorption of Eu(III) on granite: EPMA, LA-ICP-MS, batch and modeling studies.

    Science.gov (United States)

    Fukushi, Keisuke; Hasegawa, Yusuke; Maeda, Koushi; Aoi, Yusuke; Tamura, Akihiro; Arai, Shoji; Yamamoto, Yuhei; Aosai, Daisuke; Mizuno, Takashi

    2013-11-19

    Eu(III) sorption on granite was assessed using combined microscopic and macroscopic approaches in neutral to acidic conditions where the mobility of Eu(III) is generally considered to be high. Polished thin sections of the granite were reacted with solutions containing 10 μM of Eu(III) and were analyzed using EPMA and LA-ICP-MS. On most of the biotite grains, Eu enrichment up to 6 wt % was observed. The Eu-enriched parts of biotite commonly lose K, which is the interlayer cation of biotite, indicating that the sorption mode of Eu(III) by the biotite is cation exchange in the interlayer. The distributions of Eu appeared along the original cracks of the biotite. Those occurrences indicate that the prior water-rock interaction along the cracks engendered modification of biotite to possess affinity to the Eu(III). Batch Eu(III) sorption experiments on granite and biotite powders were conducted as functions of pH, Eu(III) loading, and ionic strength. The macroscopic sorption behavior of biotite was consistent with that of granite. At pH > 4, there was little pH dependence but strong ionic strength dependence of Eu(III) sorption. At pH 4 was reproducible reasonably by the modeling considering single-site cation exchange reactions. The decrease of Eu(III) sorption at pH < 4 was explained by the occupation of exchangeable sites by dissolved cationic species such as Al and Fe from granite and biotite in low-pH conditions. Granites are complex mineral assemblages. However, the combined microscopic and macroscopic approaches revealed that elementary reactions by a single mineral phase can be representative of the bulk sorption reaction in complex mineral assemblages.

  19. [Genetic divergence of Vipera berus and Vipera nikolskii (Reptilia: Viperidae, Vipera) populations in lower Volga and adjacent territories assessed according to the sequences of cytochrome oxidase III 12S ribosome RNA genes].

    Science.gov (United States)

    Efimov, R V; Zav'ialov, E V; Velikov, V A; Tabachishin, V G

    2008-02-01

    The nucleotide sequences of mitochondrial genome fragments containing the genes coding for cytochrome oxidase subunit III (COIII) and 12S ribosomal RNA of common European viper and Nikolsky's viper from various habitats (Saratov, Samara, and Penza oblasts; Chuvash Republic; and the Republic of Mordovia) were determined. According to the sequencing data, all samples clustered into two groups except for a number of individuals carrying single mutations in the genes in question. One group comprised V. nikolskii from Saratov oblast and the other, V. berus from the Chuvash Republic, Republic of Mordovia, and Samara and Penza oblasts. These results comply with the available data on the karyotypes of the studied vipers of this region. Further genetic studies of V. nikolskii and V. berus from various parts of this area are necessary.

  20. A Critical Challenge: The Engagement and Assessment of Contingent, Part-Time Adjunct Faculty Professors in United States Community Colleges

    Science.gov (United States)

    Jolley, Michael R.; Cross, Emily; Bryant, Miles

    2014-01-01

    In 2011, according to a National Center for Education Statistics report, part-time instructional staff in all higher education institutions exceeded full-time faculty members for the first time, accounting for 50% of all instructional staff (National Center for Education Statistics [NCES], 2012). The same report indicates part-time faculty in…

  1. Development of a guidance manual for the identification and assessment of interactions as part of Environmental Impact Assessment; Entwicklung einer Arbeitsanleitung zur Beruecksichtigung der Wechselwirkungen in der Umweltvertraeglichkeitspruefung

    Energy Technology Data Exchange (ETDEWEB)

    Rassmus, J.; Bruening, H.; Kleinschmidt, V.; Reck, H.; Dierssen, K.; Bonk, A. [Kiel Univ. (Germany). Oekologie-Zentrum

    2001-03-01

    The objective of the project was the development of a practice-oriented guidance manual for the identification and assessment of interactions as part of EIA. The guidance manual is to assist developers and their consultants in identifying the effects of a project on interactions and adequately describing them in the application dossier and to support the authorities in subsequent assessment. Based inter alia on a review of relevant literature and through the performance of workshops, relevant legal principles and scientific knowledge (notably current knowledge from ecosystem research), guidelines, procedural instructions and similar documents from Germany and elsewhere as well as the approaches applied in EIA practice were evaluated and further developed. On this basis, a definition of 'interactions' was in the project, which defines interactions within the meaning of the Eu's EIA Directive and Art. 2 of the German Environmental Impact Assessment Act as processes which occur in the environment. The analysis of effect chains and webs, as often carried out in EIA practice to date, already enables an extensive identification and characterisation of processes/interactions, since the elements of the chains and webs are interlinked by processes. Here, the guidance manual developed in the project goes one step farther in that it recommends a procedure for the systematic analysis of effect chains and webs, with defined interfaces for data delivery from one specialist to another which are situated at the points where these chains or webs meet. The effects of a project on interactions, as identified using the above procedure, are described in chapters specific to individual protected assets and subsequently evaluated using the conventional approach which involves the application of assessment standards (e.g., limit values laid down in the various specialised laws, precautionary guide and threshold values) according to current knowledge. As an additional module

  2. Woodcock-Johnson-III, Kaufman Adolescent and Adult Intelligence Test (KAIT), Kaufman Assessment Battery for Children (KABC), and Differential Ability Scales (DAS) support Carroll but not Cattell-Horn.

    Science.gov (United States)

    Cucina, Jeffrey M; Howardson, Garett N

    2017-08-01

    Recently emerging evidence suggests that the dominant structural model of mental abilities-the Cattell-Horn-Carroll (CHC) model-may not adequately account for observed scores for mental abilities batteries, leading scholars to call into question the model's validity. Establishing the robustness of these findings is important since CHC is the foundation for several contemporary mental abilities test batteries, such as the Woodcock-Johnson III (WJ-III). Using confirmatory factor analysis, we investigated CHC's robustness across 4 archival samples of mental abilities test battery data, including the WJ-III, the Kaufman Adolescent & Adult Intelligence Test (KAIT), the Kaufman Assessment Battery for Children (KABC), and the Differential Ability Scales (DAS). We computed omega hierarchical (ωH) and omega subscale (ωS) coefficients for g and the broad factors, which estimated the relationship of composite scores to g and the broad factors, respectively. Across all 4 samples, we found strong evidence for a general ability, g. We additionally found evidence for 3 to 9 residualized, orthogonal broad abilities existing independently of g, many of which also explained reliable variance in test battery scores that cannot be accounted for by g alone. The reliabilities of these broad factors, however, were less than desirable (i.e., <.80) and achieving desirable reliabilities would be practically infeasible (e.g., requiring excessively large numbers of subtests). Our results, and those of CHC critics, are wholly consistent with Carroll's model. Essentially, both g and orthogonal broad abilities are required to explain variance in mental abilities test battery scores, which is consistent with Carroll but not Cattell-Horn. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  3. Reducing fatalities and severe injuries on Florida's high-speed multi-lane arterial corridors : part III, county level and roadway level GIS safety analysis of state multilane corridors in Florida, final report, April 2009

    Science.gov (United States)

    2009-04-28

    This part of the study examines the locations of high trends of severe crashes (incapacitating and fatal crashes) on multilane corridors in the state of Florida at two levels, county level and roadway level. The Geographic Information System (GIS) to...

  4. Carlos III en el CSIC

    OpenAIRE

    Biblioteca Tomás Navarro Tomás (CCHS-CSIC)

    2017-01-01

    En 2016 se celebra el tercer centenario del nacimiento de Carlos III, un rey ilustrado de cuyas medidas se benefició la organización política y social de España, y muy especialmente la ciudad de Madrid. A lo largo del año se han realizado numerosos reconocimientos en forma de exposiciones, presentaciones de libros, etc. La biblioteca Tomás Navarro Tomás quiere unirse a estas celebraciones con un portal web que destaque una parte de su colección bibliográfica y documental relacionada con Carlo...

  5. Quartz and respirable dust in the Dutch construction industry: a baseline exposure assessment as part of a multidimensional intervention approach.

    Science.gov (United States)

    van Deurssen, Erik; Pronk, Anjoeka; Spaan, Suzanne; Goede, Henk; Tielemans, Erik; Heederik, Dick; Meijster, Tim

    2014-07-01

    Quartz exposure can cause several respiratory health effects. Although quartz exposure has been described in several observational workplace studies, well-designed intervention studies that investigate the effect of control strategies are lacking. This article describes a baseline exposure study that is part of a multidimensional intervention program aiming to reduce quartz exposure among construction workers. In this study, personal respirable dust and quartz exposure was assessed among 116 construction workers (bricklayers, carpenters, concrete drillers, demolishers, and tuck pointers). Possible determinants of exposure, like job, tasks, and work practices, use of control measures, and organizational and psychosocial factors, were explored using exposure models for respirable dust and quartz separately. Stratified analyses by job title were performed to evaluate the effect of control measures on exposure and to explore the association between control measures and psychosocial factors. Overall, 62% of all measurements exceeded the Dutch occupational exposure limit for quartz and 11% for respirable dust. Concrete drillers and tuck pointers had the highest exposures for quartz and respirable dust (0.20 and 3.43mg m(-3), respectively). Significant predictors of elevated quartz exposure were abrasive tasks and type of material worked on. Surprisingly, in a univariate model, an increased knowledge level was associated with an increase in exposure. Although control measures were used infrequently, if used they resulted in approximately 40% reduction in quartz exposure among concrete drillers and tuck pointers. Only among concrete drillers, the use of control measures was associated with a higher score for social influence (factor 1.6); knowledge showed an inverse association with use of control measures for concrete drillers, demolishers, and tuck pointers. In conclusion, the detailed information on determinants of exposure, use of control measures, and constraints to

  6. Interaction of Eu(III) and Cm(III) with mucin. A key component of the human mucosa

    Energy Technology Data Exchange (ETDEWEB)

    Wilke, Claudia; Barkleit, Astrid [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements

    2017-06-01

    To evaluate the potential health risks caused by the ingestion of lanthanides (Ln) and actinides (An), investigations into the chemical behavior of these metals in the human gastrointestinal tract are necessary. Mucin is an important part of the protective mucosa layer in the digestive system. We have recently reported that mucin interacts strongly with Eu(III) and Cm(III), representatives of Ln(III) and An(III), respectively, under in vivo conditions. In order to investigate the complexation behavior of this protein with Ln(III)/An(III), TRLFS measurements were performed on Eu(III)/Cm(III)-mucin solutions with different protein concentrations and at different pH. The results indicate the formation of at least two independent mucin species. At higher pH, the formation of hydroxide species was also observed.

  7. Evaluation bias in objective response rate and disease control rate between blinded independent central review and local assessment: a study-level pooled analysis of phase III randomized control trials in the past seven years.

    Science.gov (United States)

    Zhang, Jianrong; Zhang, Yiyin; Tang, Shiyan; Liang, Hengrui; Chen, Difei; Jiang, Long; He, Qihua; Huang, Yu; Wang, Xinyu; Deng, Kexin; Jiang, Shuhan; Zhou, Jiaqing; Xu, Jiaxuan; Chen, Xuanzuo; Liang, Wenhua; He, Jianxing

    2017-12-01

    In previous studies, complete-case implementation of blind independent central review has been considered unnecessary based on no sign of systematic bias between central and local assessments. In order to further evaluate its value, this study investigated evaluation status between both assessments in phase III trials of anti-cancer drugs for non-hematologic solid tumors. Eligible trials were searched in PubMed with the date of Jan 1, 2010 to Jun 30, 2017. We compared objective response rate (ORR) and disease control rate (DCR) between central and local assessments by study-level pooled analysis and correlation analysis. In pooled analysis, direct comparison was measured by the odds ratio (OR) of central-assessed response status to local-assessed response status; to investigate evaluation bias between central and local assessments, the above calculated OR between experimental (exp-) and control (con-) arms were compared, measured by the ratio of OR. A total of 28 included trials involving 17,466 patients were included (28 with ORR, 16 with DCR). Pooled analysis showed central assessment reported lower ORR and DCR than local assessment, especially in trials with open-label design, central-assessed primary endpoint, and positive primary endpoint outcome, respectively. However, this finding could be found in both experimental [exp-ORR: OR=0.81 (95% CI: 0.76-0.87), Pevaluation bias between two assessments was indicated through further analysis [ORR: ratio of OR=1.02 (0.97-1.07), P=0.42, I 2 =0%; DCR: ratio of OR=0.98 (0.93-1.03), P=0.37, I 2 =0%], regardless of mask (open/blind), sample size, tumor type, primary endpoint (central-assessed/local-assessed), and primary endpoint outcome (positive/negative). Correlation analysis demonstrated a high-degree concordance between central and local assessments (exp-ORR, con-ORR, exp-DCR, con-DCR: r>0.90, Passessment, but its complete-case implementation may be unnecessary.

  8. Perceptual Objective Listening Quality Assessment (POLQA), The Third Generation ITU-T Standard for End-to-End Speech Quality Measurement Part I—Temporal Alignment

    NARCIS (Netherlands)

    Beerends, J.G.; Schmidmer, C.; Berger, J.; Obermann, M.; Ullman, R.; Pomy, J.; Keyhl, M.

    2013-01-01

    In this and the companion paper Part II, the authors present the Perceptual Objective Listening Quality Assessment (POLQA), the third-generation speech quality measurement algorithm, standardized by the International Telecommunication Union in 2011 as Recommendation P.863. In contrast to the

  9. Perceptual Objective Listening Quality Assessment (POLQA), The Third Generation ITU-T Standard for End-to-End Speech Quality Measurement : Part II – Perceptual Model

    NARCIS (Netherlands)

    Beerends, J.G.; Schmidmer, C.; Berger, J.; Obermann, M.; Ullman, R.; Pomy, J.; Keyhl, M.

    2013-01-01

    In this and the companion paper Part I, the authors present the Perceptual Objective Listening Quality Assessment (POLQA), the third-generation speech quality measurement algorithm, standardized by the International Telecommunication Union in 2011 as Recommendation P.863. This paper describes the

  10. Safety assessment in plant layout design using indexing approach: implementing inherent safety perspective. Part 2-Domino Hazard Index and case study.

    Science.gov (United States)

    Tugnoli, Alessandro; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio

    2008-12-15

    The design of layout plans requires adequate assessment tools for the quantification of safety performance. The general focus of the present work is to introduce an inherent safety perspective at different points of the layout design process. In particular, index approaches for safety assessment and decision-making in the early stages of layout design are developed and discussed in this two-part contribution. Part 1 (accompanying paper) of the current work presents an integrated index approach for safety assessment of early plant layout. In the present paper (Part 2), an index for evaluation of the hazard related to the potential of domino effects is developed. The index considers the actual consequences of possible escalation scenarios and scores or ranks the subsequent accident propagation potential. The effects of inherent and passive protection measures are also assessed. The result is a rapid quantification of domino hazard potential that can provide substantial support for choices in the early stages of layout design. Additionally, a case study concerning selection among various layout options is presented and analyzed. The case study demonstrates the use and applicability of the indices developed in both parts of the current work and highlights the value of introducing inherent safety features early in layout design.

  11. Improving and standardising assessment of patients with immune-mediated neuropathies: Peripheral Neuropathy outcome measures Standardisation study (PeriNomS study – part 1)

    NARCIS (Netherlands)

    S.I. van Nes (Sonja)

    2012-01-01

    textabstractIn this thesis, the outline and the results of the fi rst part of the Peripheral Neuropathy outcome measures Standardisation (PeriNomS) study are described. The PeriNomS study aims to improve and standardise the assessment of patients with immune-mediated neuropathies. These disorders

  12. Assessing the prevalence of the Metabolic Syndrome according to NCEP ATP III in Germany: feasibility and quality aspects of a two step approach in 1550 randomly selected primary health care practices

    Directory of Open Access Journals (Sweden)

    Jöckel, Karl-Heinz

    2006-10-01

    Full Text Available Objective: Metabolic Syndrome (MetSyn describes a cluster of metabolic disorders and is considered a risk factor for development of cardiovascular disease. Although a high prevalence is commonly assumed in Germany data about the degree of its occurrence in the population and in subgroups are still missing. The aim of this study was to assess the prevalence of the MetSyn according to the NCEP ATP-III (National Cholesterol Education Program Adult Treatment Panel III criteria in persons aged ≥18 years attending a general practitioner in Germany. Here we describe in detail the methods used and the feasibility of determining the MetSyn in a primary health care setting. Research design and methods: The German-wide cross-sectional study was performed during two weeks in October 2005. Blood samples were analyzed in a central laboratory. Waist circumference and blood pressure were assessed, data on smoking, life style, fasting status, socio-demographic characteristics and core information from non-participants collected. Quality control procedures included telephone-monitoring and random on-site visits. In order to achieve a maximal number of fasting blood samples with a minimal need for follow-up appointments a stepwise approach was developed. Basic descriptive statistics were calculated, the Taylor expansion method used to estimate standard errors needed for calculation of confidence intervals for clustered observations. Results: In total, 1511 randomly selected general practices from 397 out of 438 German cities and administrative districts enrolled 35,869 patients (age range: 18-99, women 61.1%. More than 50,000 blood samples were taken. Fasting blood samples were available for 49% of the participants. Of the participating patients 99.3% returned questionnaires to the GP, only 12% were not filled out completely. The overall prevalence of the MetSyn (NCEP/ATP III 2001 was found to be 19.8%, with men showing higher prevalence rates than women (22

  13. Stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit in Jaworzno III Power Plant – Power Plant II

    National Research Council Canada - National Science Library

    Karpiński Marcin; Kmiecik Ewa

    2017-01-01

    .... In order to minimise the negative impact on the surface water, the plant replenishes the cooling circuit with the mining water obtained from the closed-down Jan Kanty mine. The paper presents a stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit based on the data from 2007–2017.

  14. Phase I/II clinical trial to assess safety and efficacy of intratumoral and subcutaneous injection of HVJ-E in castration-resistant prostate cancer patients.

    Science.gov (United States)

    Fujita, K; Nakai, Y; Kawashima, A; Ujike, T; Nagahara, A; Nakajima, T; Inoue, T; Lee, C M; Uemura, M; Miyagawa, Y; Kaneda, Y; Nonomura, N

    2017-07-01

    Inactivated Sendai virus particles (hemagglutinating virus of Japan envelope (HVJ-E)) have a novel antitumor effect: HVJ-E fused to prostate cancer cells via cell surface receptor causes apoptosis of prostate cancer cells in vitro and in vivo. HVJ-E also induces antitumor immunity by activating natural killer (NK) cells and cytotoxic T cells and suppressing regulatory T cells in vivo. We conducted an open-label, single-arm, phase I/II clinical trial in patients with castration-resistant prostate cancer (CRPC) to determine the safety and efficacy of intratumoral and subcutaneous injection of HVJ-E. Patients with CRPC who were docetaxel-resistant or could not receive docetaxel treatment were eligible. HVJ-E was injected directly into the prostate on day 1 and subcutaneously on days 5, 8 and 12 in two 28-day treatment cycles using a 3+3 dose-escalation design. The primary end points were to evaluate safety and tolerability of HVJ-E. The secondary end points were to analyze tumor immunity and antitumor effect. The study is registered at UMIN Clinical Trials Registry, number UMIN000006142. Seven patients were enrolled, and six patients received HVJ-E. Grade 2 or 3 adverse events (Common Terminology Criteria for Adverse Events Ver. 4.0) were urinary retention and lymphopenia from which the patients recovered spontaneously. No Grade 4 adverse events were observed. Radiographically, three patients had stable disease in the low-dose group, and one patient had stable disease and two had progressive disease in the high-dose group. The prostate-specific antigen (PSA) declined from 14 to 1.9 ng ml(-1) in one patient in the low-dose group after two cycles of HVJ-E treatment, and the PSA response rate was 16.6%. NK cell activity was elevated from day 12 to day 28 after HVJ-E administration, whereas serum interleukin-6, interferon (IFN)-α, IFN-β and IFN-γ levels were not affected by HVJ-E treatment. Intratumoral and subcutaneous injections of HVJ-E are feasible and PSA

  15. Whole effluent assessment of industrial wastewater for determination of BAT compliance. Part 2: metal surface treatment industry.

    Science.gov (United States)

    Gartiser, Stefan; Hafner, Christoph; Hercher, Christoph; Kronenberger-Schäfer, Kerstin; Paschke, Albrecht

    2010-06-01

    Toxicity testing has become a suitable tool for wastewater evaluation included in several reference documents on best available techniques of the Integrated Pollution Prevention and Control (IPPC) Directive. The IPPC Directive requires that for direct dischargers as well as for indirect dischargers, the same best available techniques should be applied. Within the study, the whole effluent assessment approach of OSPAR has been applied for determining persistent toxicity of indirectly discharged wastewater from the metal surface treatment industry. Twenty wastewater samples from the printed circuit board and electroplating industries which indirectly discharged their wastewater to municipal wastewater treatment plants (WWTP) have been considered in the study. In all factories, the wastewater partial flows were separated in collecting tanks and physicochemically treated in-house. For assessing the behaviour of the wastewater samples in WWTPs, all samples were biologically pretreated for 7 days in the Zahn-Wellens test before ecotoxicity testing. Thus, persistent toxicity could be discriminated from non-persistent toxicity caused, e.g. by ammonium or readily biodegradable compounds. The fish egg test with Danio rerio, the Daphnia magna acute toxicity test, the algae test with Desmodesmus subspicatus, the Vibrio fischeri assay and the plant growth test with Lemna minor have been applied. All tests have been carried out according to well-established DIN or ISO standards and the lowest ineffective dilution (LID) concept. Additionally, genotoxicity was tested in the umu assay. The potential bioaccumulating substances (PBS) were determined by solid-phase micro-extraction and referred to the reference compound 2,3-dimethylnaphthalene. The chemical oxygen demand (COD) and total organic carbon (TOC) values of the effluents were in the range of 30-2,850 mg L(-1) (COD) and 2-614 mg L(-1) (TOC). With respect to the metal concentrations, all samples were not heavily polluted. The

  16. NNDSS - Table III. Tuberculosis

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table III. Tuberculosis - 2017.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  17. Pseudo Class III malocclusion

    National Research Council Canada - National Science Library

    Al-Hummayani, Fadia M

    2016-01-01

    .... This case report represents a none traditional treatment modality to treat deep anterior crossbite in an adult pseudo class III malocclusion complicated by severely retruded, supraerupted upper and lower incisors...

  18. RELAP-7 Software Verification and Validation Plan - Requirements Traceability Matrix (RTM) Part 2: Code Assessment Strategy, Procedure, and RTM Update

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jun Soo [Idaho National Lab. (INL), Idaho Falls, ID (United States); Choi, Yong Joon [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Curtis Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    This document addresses two subjects involved with the RELAP-7 Software Verification and Validation Plan (SVVP): (i) the principles and plan to assure the independence of RELAP-7 assessment through the code development process, and (ii) the work performed to establish the RELAP-7 assessment plan, i.e., the assessment strategy, literature review, and identification of RELAP-7 requirements. Then, the Requirements Traceability Matrices (RTMs) proposed in previous document (INL-EXT-15-36684) are updated. These RTMs provide an efficient way to evaluate the RELAP-7 development status as well as the maturity of RELAP-7 assessment through the development process.

  19. HISTORY OF EMPLOYMENT AND MANPOWER POLICY IN THE UNITED STATES. PARTS III AND IV, LOOKING AHEAD TO THE POSTWAR ECONOMY AND THE CONCEPT OF FULL EMPLOYMENT IN CONGRESS. SELECTED READINGS IN EMPLOYMENT AND MANPOWER, VOLUME 6.

    Science.gov (United States)

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

    THE SELECTED READINGS WERE COMPILED TO PROVIDE SUBCOMMITTEE MEMBERS WITH A BROAD BACKGROUND OF DEVELOPMENTS LEADING TO THE EMPLOYMENT ACT OF 1946 AND ARE CONCERNED WITH THE FORMULATION OF U.S. EMPLOYMENT POLICIES FOLLOWING WORLD WAR II. PARTS I AND II (VT 004 819) PROVIDE THE HISTORICAL BACKGROUND FROM THE LATE 1920'S THROUGH THE GREAT DEPRESSION.…

  20. Free Radicals and Reactive Intermediates for the SAGE III Ozone Loss and Validation Experiment (SOLVE) Mission

    Science.gov (United States)

    Anderson, James G.

    2001-01-01

    This grant provided partial support for participation in the SAGE III Ozone Loss and Validation Experiment. The NASA-sponsored SOLVE mission was conducted Jointly with the European Commission-sponsored Third European Stratospheric Experiment on Ozone (THESEO 2000). Researchers examined processes that control ozone amounts at mid to high latitudes during the arctic winter and acquired correlative data needed to validate the Stratospheric Aerosol and Gas Experiment (SAGE) III satellite measurements that are used to quantitatively assess high-latitude ozone loss. The campaign began in September 1999 with intercomparison flights out of NASA Dryden Flight Research Center in Edwards. CA. and continued through March 2000. with midwinter deployments out of Kiruna. Sweden. SOLVE was co-sponsored by the Upper Atmosphere Research Program (UARP). Atmospheric Effects of Aviation Project (AEAP). Atmospheric Chemistry Modeling and Analysis Program (ACMAP). and Earth Observing System (EOS) of NASA's Earth Science Enterprise (ESE) as part of the validation program for the SAGE III instrument.

  1. Observational Assessment of Preschool Disruptive Behavior, Part II: Validity of the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS)

    Science.gov (United States)

    Wakschlag, Lauren S.; Briggs-Gowan, Margaret J.; Hill, Carri; Danis, Barbara; Leventhal, Bennett L.; Keenan, Kate; Egger, Helen L.; Cicchetti, Domenic; Burns, James; Carter, Alice S.

    2008-01-01

    A study is conducted to determine whether the multidomain, multicontext Disruptive Behavior Diagnostic Observation Schedule (DB-DOS) is a valid observational method for assessing disruptive behavior of preschool children. It is concluded that the DB-DOS is a valid method for a direct observational assessment of clinically significant disruptive…

  2. What Is the Functional Value of the GMAT Analytical Writing Assessment for Management Education? A Critical Analysis, Part 2.

    Science.gov (United States)

    Rogers, Priscilla S.; Rymer, Jone

    1995-01-01

    Analyzes the Analytical Writing Assessment's (AWA) contribution as a performance assessment. Critiques its potential usefulness as a diagnostic tool for management education. Concludes that the AWA does not meet the expectations of GMAT-user schools who endorsed the test as a diagnostic instrument for identifying student deficiencies. States that…

  3. What Is the Relevance of the GMAT Analytical Writing Assessment for Management Education? A Critical Analysis, Part I.

    Science.gov (United States)

    Rogers, Priscilla S.; Rymer, Jone

    1995-01-01

    Comments on the Analytical Writing Assessment (AWA), a new component of the Graduate Management Admissions Test (GMAT). Examines the AWA's historical significance and addresses questions regarding the relevance of the writing test for management education. Finds that the AWA is of limited value as a writing assessment and will meet only some of…

  4. The assessment of function. Part II: clinical perspective of a javelin thrower with low back and groin pain

    Science.gov (United States)

    Reiman, Michael P; Manske, Robert C

    2012-01-01

    Assessment of an individual’s functional ability can be complex. This assessment should also be individualized and adaptable to changes in functional status. In the first article of this series, we operationally defined function, discussed the construct of function, examined the evidence as it relates to assessment methods of various aspects of function, and explored the multi-dimensional nature of the concept of function. In this case report, we aim to demonstrate the utilization of a multi-dimensional assessment method (functional performance testing) as it relates to a high-level athlete presenting with pain in the low back and groin. It is our intent to demonstrate how the clinician should continually adapt their assessment dependent on the current functional abilities of the patients. PMID:23633887

  5. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The ability of uranium supply and the rest of the nuclear fuel cycle to meet the demand for nuclear power is an important consideration in future domestic and international planning. Accordingly, the purpose of this assessment is to evaluate the adequacy of potential supply for various nuclear resources and fuel cycle facilities in the United States and in the world outside centrally planned economy areas (WOCA). Although major emphasis was placed on uranium supply and demand, material resources (thorium and heavy water) and facility resources (separative work, spent fuel storage, and reprocessing) were also considered.

  6. PBL on Line: A Proposal for the Organization, Part-Time Monitoring and Assessment of PBL Group Activities

    Science.gov (United States)

    Marti, Enric; Gil, Debora; Gurguí, Antoni; Hernández-Sabaté, Aura; Rocarías, Jaume; Poveda, Ferran

    2015-01-01

    This report presents the organisation of PBL (Project Based Learning) for a subject included in the IT engineering degree course. It is the result of 10 years of experience of the implantation and continuous improvement of the PBL class structure. The latest innovations include the experience of part-time monitoring with PBL groups using the Open…

  7. Fe (III) complex of mefloquine hydrochloride: Synthesis ...

    African Journals Online (AJOL)

    As part of the ongoing research for more effective antimalarial drug, Fe (III) complex of mefloquine hydrochloride (antimalarial drug) was synthesized using template method. Mefloquine was tentatively found to have coordinated through the hydroxyl and the two nitrogen atoms in the quinoline and piperidine in the structure, ...

  8. Mathematics for engineers III vector calculus

    CERN Document Server

    Baumann, Gerd

    2011-01-01

    This book is part of a four-volume textbook on Engineering Mathematics for undergraduates. Volume III treats vector calculus and differential equations of higher order. The text uses Mathematica as a tool to discuss and to solve examples from mathematics. The basic use of this language is demonstrated by examples.

  9. SAGE III aerosol extinction validation in the Arctic winter: comparisons with SAGE II and POAM III

    Directory of Open Access Journals (Sweden)

    L. W. Thomason

    2007-01-01

    Full Text Available The use of SAGE III multiwavelength aerosol extinction coefficient measurements to infer PSC type is contingent on the robustness of both the extinction magnitude and its spectral variation. Past validation with SAGE II and other similar measurements has shown that the SAGE III extinction coefficient measurements are reliable though the comparisons have been greatly weighted toward measurements made at mid-latitudes. Some aerosol comparisons made in the Arctic winter as a part of SOLVE II suggested that SAGE III values, particularly at longer wavelengths, are too small with the implication that both the magnitude and the wavelength dependence are not reliable. Comparisons with POAM III have also suggested a similar discrepancy. Herein, we use SAGE II data as a common standard for comparison of SAGE III and POAM III measurements in the Arctic winters of 2002/2003 through 2004/2005. During the winter, SAGE II measurements are made infrequently at the same latitudes as these instruments. We have mitigated this problem through the use of potential vorticity as a spatial coordinate and thus greatly increased of the number of coincident events. We find that SAGE II and III extinction coefficient measurements show a high degree of compatibility at both 1020 nm and 450 nm except a 10–20% bias at both wavelengths. In addition, the 452 to 1020 nm extinction ratio shows a consistent bias of ~30% throughout the lower stratosphere. We also find that SAGE II and POAM III are on average consistent though the comparisons show a much higher variability and larger bias than SAGE II/III comparisons. In addition, we find that SAGE II and POAM III data sets are not well correlated at and below 18 km. Overall, we find both the extinction values and the spectral dependence from SAGE III are robust and we find no evidence of a significant defect within the Arctic vortex.

  10. A prospective study to assess the surgical outcome in three- and four-part proximal humerus fracture with PHILOS plate

    Directory of Open Access Journals (Sweden)

    Mahantesh Y Patil

    2012-01-01

    Full Text Available Background: Optimal surgical management of three- and four-part proximal humeral fractures in osteoporotic patients is controversial, with many advocating prosthetic replacement of the humeral head. Proximal humerus interlocking osteosyntheses that maintain angular stability under load have been proposed as an alternative to hemiarthroplasty for the treatment of three- and four-part proximal humeral fractures. Materials and Methods: The records showed 50 patients, with a mean age of 57.5 years. The Neer three-part proximal humeral fractures were 18 in number, and the four-part proximal humeral fractures were 32. All the patients were treated surgically between January 2008 and December 2010. All patients had a radiographic and clinical follow-up performed at one, three, and six months and at one year. The clinical outcomes were measured with the use of the Constant-Murley system. This study was based on level 1 of the evidence. Results: The mean Constant score (and standard deviation at the time of the final follow-up was better in the locked-plate group. The mean Constant score was 80 (range, 40 - 100. Complications with this fixation included osteonecrosis in one patient, malunion in one patient, Axillary nerve palsy in one patient, and impingement syndrome in one patient. Conclusions: The most important factor for a favorable outcome in three- and four-part fractures in the proximal end humerus gives an accurate anatomical reduction, which is achieved by locking plate osteosynthesis, with multiplanar screws. It is a safe and effective method, with minimal tissue damage, higher primary stability, and load transfer through the implant, which are important to avoid complications. The PHILOS Plate produces promising functional outcomes.

  11. International guidelines for the in vivo assessment of skin properties in non-clinical settings: part 1. pH

    Science.gov (United States)

    Stefaniak, Aleksandr B; du Plessis, Johan; John, Swen M; Eloff, Fritz; Agner, Tove; Chou, Tzu-Chieh; Nixon, Rosemary; Steiner, Markus F C; Kudla, Irena; Holness, D Linn

    2013-01-01

    Background Skin surface pH is known to influence the dissolution and partitioning of chemicals and may influence exposures that lead to skin diseases. Non-clinical environments (e.g. workplaces) are highly variable, thereby presenting unique measurement challenges that are not typically encountered in clinical settings. Hence, guidelines are needed for consistent measurement of skin surface pH in environments that are difficult to control. Methods An expert workshop was convened at the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals to review available data on factors that could influence the determination of skin surface pH in non-clinical settings with emphasis on the workplace as a worst case scenario. Results The key elements of the guidelines are: (i) minimize, to the extent feasible, the influences of relevant endogenous (anatomical position, skin health, time of day), exogenous (hand washing, barrier creams, soaps and detergents, occlusion), environmental (seasonality), and measurement (atmospheric conditions) factors; (ii) report pH measurements results as a difference or percent change (not absolute values) using a measure of central tendency and variability; and (iii) report notable deviations from these guidelines and other relevant factors that may influence measurements. Conclusion Guidelines on the measurement and reporting of skin surface pH in non-clinical settings should promote consistency in data reporting, facilitate inter-comparison of study results, and aid in understanding and preventing occupational skin diseases. PMID:23279097

  12. Quality and monitoring of structural rehabilitation measures , part 2 : review and assessment of non-destructive testing (NDT) techniques.

    Science.gov (United States)

    2002-03-01

    As CFRP composites continue to gain acceptance in structural rehabilitation of deteriorating infrastructure, the consequent need for comprehensive and rapid in-situ quality assessment has arisen. Conditioned by the inevitable presence of material-, i...

  13. Proposed changes in personality and personality disorder assessment and diagnosis for DSM-5 part I: description and rationale

    NARCIS (Netherlands)

    Skodol, A.E.; Clark, L.A.; Bender, D.S.; Krueger, R.F.; Morey, L.C.; Verheul, R.; Alarcon, R.D.; Bell, C.C.; Siever, L.J.; Oldham, J.M.

    2011-01-01

    A major reconceptualization of personality psychopathology has been proposed for DSM-5 that identifies core impairments in personality functioning, pathological personality traits, and prominent pathological personality types. A comprehensive personality assessment consists of four components:

  14. The Clinical effectiveness of sequential treatment of skeletal class III ...

    African Journals Online (AJOL)

    Aim: To assess the dentofacial changes induced by the sequential treatment in the skeletal class III malocclusion with maxillary retrognathism. Study design: Controlled clinical trial assessing the effectiveness of sequential treatment of skeletal class III malocclusion. Materials and Methods: The treated group consisted of 30 ...

  15. Complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III)

    OpenAIRE

    Ferenc, W.; Bernat, M.; Sarzyński, J.; Głuchowska, H.

    2010-01-01

    The complexes of 4-chlorophenoxyacetates of Nd(III), Gd(III) and Ho(III) have been synthesized as polycrystalline hydrated solids, and characterized by elemental analysis, spectroscopy, magnetic studies and also by X-ray diffraction and thermogravimetric measurements. The analysed complexes have the following colours: violet for Nd(III), white for Gd(III) and cream for Ho(III) compounds. The carboxylate groups bind as bidentate chelating (Ho) or bridging ligands (Nd, Gd). On heating to 1173K ...

  16. McKenzie River Subbasin Assessment, Technical Report 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Alsea Geospatial, Inc.

    2000-02-01

    This document details the findings of the McKenzie River Subbasin Assessment team. The goal of the subbasin assessment is to provide an ecological assessment of the McKenzie River Floodplain, identification of conservation and restoration opportunities, and discussion of the influence of some upstream actions and processes. This Technical Report can be viewed in conjunction with the McKenzie River Subbasin Summary or as a stand-alone document. The purpose of the technical report is to detail the methodology and findings of the consulting team that the observations and recommendations in the summary document are based on. This part, Part I, provides an introduction to the subbasin and a general overview. Part II details the specific findings of the science team. Part III provides an explanation and examples of how to use the data that has been developed through this assessment to aid in prioritizing restoration activities. Part III also includes the literature cited and appendices.

  17. Al Ain Community Survey of Psychiatric Morbidity III. The natural history of psychopathology and the utilization rate of psychiatric services in Al Ain.

    Science.gov (United States)

    Daradkeh, T K; Ghubash, R; Abou-Saleh, M T

    2000-12-01

    We evaluated the natural history of psychopathology in a stratified sample (n = 245) comprising subjects with no DSM-III-R psychiatric disorder, subthreshold disorder and threshold (DSM-III-R) psychiatric disorder, respectively, over a 12-months period, using the Structured Clinical Interview for DSM-III-R mental disorders (SCID) as an assessment tool. A representative sample categorized 1 year earlier into DSM-III-R psychiatric disorder, subthreshold disorder and no DSM-III-R psychiatric disorder were reassessed with SCID 1 year on. The incidence, recovery rates and the percentage of subthreshold disorders which become DSM-III-R disorders were calculated. The utilization rate of psychiatric services was also assessed. The incidence rate of new cases was 10.4%. The recovery (remission) rate was 41.5%, and approximately 20% of subthreshold disorders became definitive disorders (DSM-III-R) after 1 year. Anxiety disorders tend to have a higher magnitude of temporal stability in comparison with depressive disorders. Male sex and contact with psychiatric services were found to affect the recovery rate. Approximately 13% of the sample had made contact with psychiatric services with no gender differences, but men were significantly more often hospitalized than women. Our findings indicate that mental disorders are relatively common. The high incidence rate found in this study is attributed in part to the high negative rate at baseline assessment. Approximately 60% of psychiatric disorders in the community are persistent, and patients with emotional disorder under-utilize existing services.

  18. Implementation of evidence-based humanitarian programs in military-led missions: part II. The impact assessment model.

    Science.gov (United States)

    Reaves, Erik J; Schor, Kenneth W; Burkle, Frederick M

    2008-12-01

    The Department of Defense does not implement health-sector humanitarian assistance impact assessments to complement those of the international humanitarian aid community. This oversight fails to meet the recent Department of Defense Directive 3000.05 mandate calling for the application of measures of effectiveness. The decision by the Department of Defense to incorporate humanitarian assistance in stability operations should be supported by evidence-based impact assessments. This article proposes implementation of an impact assessment model in Department of Defense humanitarian assistance operations. The use of an impact assessment model will refocus previously identified information gaps from traditional military input-output management toward a greater emphasis on outcomes. This will help answer which humanitarian activities are successful, which are not, and why. Over time, the use of an impact assessment model will ensure that the Department of Defense and its operational units are learning as an organization while applying evidence-based lessons learned to future stability operations. Most important, the use of this model will both provide better understanding of the role that the Department of Defense has in humanitarian activities and help interpret and transfer these activities to the host nation and international aid community in a timely and efficient manner.

  19. Lutetium(III cyclotetraphosphate

    Directory of Open Access Journals (Sweden)

    Aïcha Mbarek

    2010-06-01

    Full Text Available Single crystals of the title compound, tetralutetium(III tris(cyclotetraphosphate, Lu4(P4O123, were obtained by solid-state reaction. The cubic structure is isotypic with its AlIII and ScIII analogues and is built up from four-membered (P4O124− phosphate ring anions (overline{4} symmetry, isolated from each other and further linked through isolated LuO6 octahedra (.3. symmetry via corner sharing. Each LuO6 octahedron is linked to six (P4O124− rings, while each (P4O124− ring is linked to eight LuO6 octahedra.

  20. The use and abuse of attachment theory in clinical practice with maltreated children, part I: diagnosis and assessment.

    Science.gov (United States)

    Allen, Brian

    2011-01-01

    Debate has ensued regarding the appropriate assessment and diagnosis for school-age children who display severe behavioral problems as a result of previous abuse and neglect within the primary attachment relationship. The current nomenclature recognizes reactive attachment disorder and some clinicians have suggested broader categories of attachment disorder. These attempts at classification are often criticized on empirical grounds; however, often lost in these criticisms is the fact that that these diagnostic approaches often misapply attachment theory and research. This article summarizes the original contributions of John Bowlby and other attachment researchers to our understanding of child development, examines misguided attempts to apply attachment theory to the diagnosis and assessment of maltreated children, and offers a diagnostic conceptualization and assessment recommendations consistent with the available attachment research.

  1. Phase III Study to Assess Long-Term (52-Week) Safety and Efficacy of Mirabegron, a β3 -Adrenoceptor Agonist, in Japanese Patients with Overactive Bladder.

    Science.gov (United States)

    Yamaguchi, Osamu; Ikeda, Yasushi; Ohkawa, Sumito

    2017-01-01

    To investigate safety, tolerability and efficacy of long-term (52 weeks) open-label treatment with mirabegron 50 mg, with an optional dose increase to 100 mg, in patients with overactive bladder (OAB). Patients received mirabegron 50 mg once daily for 52 weeks. If efficacy was insufficient at week 8, the dose could be increased to 100 mg. Safety was evaluated based on vital signs, adverse events (AEs), laboratory findings, electrocardiogram and post-void residual volume. Treatment efficacy was assessed with a 3-day micturition diary and the King's Health Questionnaire (KHQ). Two hundred and four patients were enrolled; mirabegron dose was maintained at 50 mg in 153 patients and increased to 100 mg in 50 patients. Mirabegron was well tolerated at both doses. Incidences of AEs and treatment-related AEs were 91.4% and 33.6% in patients on 50 mg, and 100% and 30.0% in patients on 100 mg, respectively. Time course changes in systolic or diastolic blood pressure and pulse rate were not considered clinically significant. At the end of treatment (EOT), patients on 50 mg and 100 mg showed improvement in frequency and urgency. Improvements from baseline to EOT in quality of life scores were observed for all KHQ domains. There were no safety or tolerability concerns associated with mirabegron 50 mg (with an optional dose increase to 100 mg) over 52 weeks. Improvement in micturition variables was maintained with mirabegron 50 mg from weeks 8 to 52. © 2015 Wiley Publishing Asia Pty Ltd.

  2. III-V microelectronics

    CERN Document Server

    Nougier, JP

    1991-01-01

    As is well known, Silicon widely dominates the market of semiconductor devices and circuits, and in particular is well suited for Ultra Large Scale Integration processes. However, a number of III-V compound semiconductor devices and circuits have recently been built, and the contributions in this volume are devoted to those types of materials, which offer a number of interesting properties. Taking into account the great variety of problems encountered and of their mutual correlations when fabricating a circuit or even a device, most of the aspects of III-V microelectronics, from fundamental p

  3. 20 CFR Appendix III to Subpart C... - Benefit Table

    Science.gov (United States)

    2010-04-01

    ... of Part 404 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts Pt. 404, Subpt. C, App. III Appendix III to... their benefit computed from this table. However, the minimum benefit provision was repealed for other...

  4. Correlation between different PBL assessment components and the ...

    African Journals Online (AJOL)

    ... significant with the TUT. Conclusion. There was good correlation between the students' performance in the majority of assessment modalities and the final mark in the different blocks of the MB ChB III examination. There may be a need to make tutorial assessment methods more objective, partly by additional tutor training.

  5. Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 1 : technical description

    NARCIS (Netherlands)

    Koppelstaetter, Christian; Jennings, Paul; Ryan, Michael P; Morin, Jean-Paul; Hartung, Thomas; Pfaller, Walter

    2004-01-01

    In vitro models for chronic toxicity, defined as a recurring exposure to compounds over a prolonged period of time, are still underrepresented in drug evaluation processes. The classical approach to cell culture is not readily suitable to long term repetitive applications. Therefore, we assessed the

  6. Assessment of novel tobacco heating product THP1.0. Part 7: Comparative in vitro toxicological evaluation.

    Science.gov (United States)

    Thorne, David; Breheny, Damien; Proctor, Christopher; Gaca, Marianna

    2018-03-01

    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study, the total particulate matter and whole aerosol from a Kentucky reference 3R4F cigarette and two commercially available tobacco heating products (THPs) were assessed using in vitro mutagenicity, cytotoxicity and tumour-promoting activity assays. The Ames assay assessed mutagenicity using Salmonella typhimurium tester strains TA98, TA100, TA1535, TA1537 and TA102 ± metabolic activation (S9). The mouse lymphoma assay was used with short 3 h and longer 24 h exposures. The Bhas 42 cell transformation assay was incorporated as an in vitro alternative for detecting tumour promoters, and the neutral red uptake cell viability assay provided an acute measure of cytotoxicity. To complement the approach, the Ames assay was also employed with S. typhimurium tester strains TA98, TA100, TA1535, TA97 and TA102 using a scaled down methodology for the assessment of aerosols. All the in vitro techniques employed produced a clear positive response with cigarette smoke and in contrast, a negative response to THPs at doses equivalent to or higher than a cigarette smoke test matrix. The data show little difference between the THPs assessed suggesting parity between products. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  7. The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease.

    Science.gov (United States)

    Rodriguez-Blazquez, Carmen; Rojo-Abuin, Jose Manuel; Alvarez-Sanchez, Mario; Arakaki, Tomoko; Bergareche-Yarza, Alberto; Chade, Anabel; Garretto, Nelida; Gershanik, Oscar; Kurtis, Monica M; Martinez-Castrillo, Juan Carlos; Mendoza-Rodriguez, Amelia; Moore, Henry P; Rodriguez-Violante, Mayela; Singer, Carlos; Tilley, Barbara C; Huang, Jing; Stebbins, Glenn T; Goetz, Christopher G; Martinez-Martin, Pablo

    2013-10-01

    To evaluate the motor experiences of daily living section of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS M-EDL) for assessing disability in PD patients; to determine the association between disability and quality of life; and to identify cut-off score ranges for no, mild, moderate and severe disability with this measure. International, observational, cross-sectional study of 435 PD patients, assessed with: MDS-UPDRS, Hoehn and Yahr staging, Rapid Assessment of Disability Scale, Clinical Impression of Severity Index for PD, Parkinson's Disease Questionnaire-8 and EQ-5D. Descriptive statistics, Spearman's rank correlation coefficients, Kruskal-Wallis test for group comparisons, ordinal logistic regression analysis for setting cut-off values and a step-wise multiple linear regression model were calculated. MDS-UPDRS M-EDL correlated 0.70-0.80 with other disability measures, and -0.46 to 0.74 with quality of life scales. Scores significantly increased with higher disease duration and severity (p MDS-UPDRS nM-EDL section as the main determinant of M-EDL, followed by the rest of MDS-UPDRS sections (explained variance: 59%). MDS-UPDRS M-EDL proved to be useful for assessing disability in PD. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II)

    DEFF Research Database (Denmark)

    Rudwaleit, M; van der Heijde, D; Landewé, R

    2009-01-01

    OBJECTIVE: To validate and refine two sets of candidate criteria for the classification/diagnosis of axial spondyloarthritis (SpA). METHODS: All Assessment of SpondyloArthritis international Society (ASAS) members were invited to include consecutively new patients with chronic (> or =3 months) ba...

  9. Aggregation of measures to produce an overall assessment of animal welfare. Part 1: a review of existing methods

    DEFF Research Database (Denmark)

    Boteau, R.; Bonde, Marianne; Butterworth, A.

    2007-01-01

    Several systems have been proposed for the overall assessment of animal welfare at the farm level for the purpose of advising farmers or assisting public decision-making. They are generally based on several measures compounded into a single evaluation, using different rules to assemble the inform...

  10. Review of methods for developing regional probabilistic risk assessments, part 2: modeling invasive plant, insect, and pathogen species

    Science.gov (United States)

    P. B. Woodbury; D. A. Weinstein

    2010-01-01

    We reviewed probabilistic regional risk assessment methodologies to identify the methods that are currently in use and are capable of estimating threats to ecosystems from fire and fuels, invasive species, and their interactions with stressors. In a companion chapter, we highlight methods useful for evaluating risks from fire. In this chapter, we highlight methods...

  11. Which part of a short, global risk assessment, the Risk Instrument for Screening in the Community, predicts adverse healthcare outcomes?

    LENUS (Irish Health Repository)

    O’Caoimh, Rónán

    2015-01-01

    The Risk Instrument for Screening in the Community (RISC) is a short, global risk assessment to identify community-dwelling older adults’ one-year risk of institutionalisation, hospitalisation, and death. We investigated the contribution that the three components of the RISC (\

  12. Environmental risk assessment for veterinary medicinal products. Part 2. The phase 1 assessment for immunological products. Report on the workshop 23-9-1998

    NARCIS (Netherlands)

    Montforts MHMM; CSR

    2000-01-01

    This report contains a proposal for a simplified Phase 1 assessment for immunological veterinary medicinal products. This scheme was constructed as it was felt that the existing guidance as given by the EMEA was too complex and laborous to reach quick decisions on the acceptability of low-risk

  13. Assessing and reporting uncertainties in dietary exposure analysis - Part II: Application of the uncertainty template to a practical example of exposure assessment.

    Science.gov (United States)

    Tennant, David; Bánáti, Diána; Kennedy, Marc; König, Jürgen; O'Mahony, Cian; Kettler, Susanne

    2017-11-01

    A previous publication described methods for assessing and reporting uncertainty in dietary exposure assessments. This follow-up publication uses a case study to develop proposals for representing and communicating uncertainty to risk managers. The food ingredient aspartame is used as the case study in a simple deterministic model (the EFSA FAIM template) and with more sophisticated probabilistic exposure assessment software (FACET). Parameter and model uncertainties are identified for each modelling approach and tabulated. The relative importance of each source of uncertainty is then evaluated using a semi-quantitative scale and the results expressed using two different forms of graphical summary. The value of this approach in expressing uncertainties in a manner that is relevant to the exposure assessment and useful to risk managers is then discussed. It was observed that the majority of uncertainties are often associated with data sources rather than the model itself. However, differences in modelling methods can have the greatest impact on uncertainties overall, particularly when the underlying data are the same. It was concluded that improved methods for communicating uncertainties for risk management is the research area where the greatest amount of effort is suggested to be placed in future. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. El Patronato «Juan de la Cierva» (1939-1960. III Parte: La investigación científica y tecnológica

    Directory of Open Access Journals (Sweden)

    López García, Santiago

    1999-01-01

    Full Text Available Not available.El presente artículo es el último de una trilogía cuyas partes precedentes han sido publicadas en los números anteriores de Arbor. Ya hemos tratado los orígenes, la organización y la financiación del Patronato. Ahora, nos fijaremos en la investigación científica y tecnológica que se llevó a cabo en el periodo de la «autarquía económica» (epígrafe 5. Al final, exponemos las conclusiones y los apéndices y bibliografía comunes a los tres escritos.

  15. Tempo, idade e cultura: uma contribuição à psicopatologia da depressão no idoso. Parte III: A depressão, o tempo e a cultura

    Directory of Open Access Journals (Sweden)

    Cláudio Lyra Bastos

    Full Text Available Procuramos aqui relacionar dois aspectos fundamentais das intuições culturais sobre a passagem do tempo - a temporalidade cíclica e a contínua - com a terapêutica médica e especialmente com a psicopatologia, numa visão crítica do constructo moderno da depressão no idoso. Inspirado em perspectivas de natureza antropológica, o texto se apoia na experiência clínica cotidiana e na atitude fenomenológica que orienta essa prática. Nas concepções culturais que tendem a perceber a passagem do tempo de forma predominantemente cíclica, o envelhecer é parte de um movimento eterno e a família se perpetua em seus descendentes, nas suas tradições, no vínculo com a terra ou no exercício do ofício familiar. As transformações culturais que têm proporcionado a passagem para enfoques mais direcionais do tempo vão destacando cada vez mais o papel individual na história social. Quanto mais difícil for a passagem de Weltanschauungen tradicionais, de tendência circular, fatalista, repetitiva e eterna para outras de tendência individualizante, burocratizante, planejadora e sucessiva, maiores as dificuldades para uma senectude satisfatória e maior a tendência à medicalização desse fracasso. Esta é a terceira parte de uma série de três artigos.

  16. Mitigation of global greenhouse gas emissions from waste: conclusions and strategies from the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report. Working Group III (Mitigation).

    Science.gov (United States)

    Bogner, Jean; Pipatti, Riitta; Hashimoto, Seiji; Diaz, Cristobal; Mareckova, Katarina; Diaz, Luis; Kjeldsen, Peter; Monni, Suvi; Faaij, Andre; Gao, Qingxian; Zhang, Tianzhu; Ahmed, Mohammed Abdelrafie; Sutamihardja, R T M; Gregory, Robert

    2008-02-01

    . Existing studies on mitigation potentials and costs for the waste sector tend to focus on landfill CH4 as the baseline. The commercial recovery of landfill CH4 as a source of renewable energy has been practised at full scale since 1975 and currently exceeds 105 Mt CO2-eq year(-1). Although landfill CH4 emissions from developed countries have been largely stabilized, emissions from developing countries are increasing as more controlled (anaerobic) landfilling practices are implemented; these emissions could be reduced by accelerating the introduction of engineered gas recovery, increasing rates of waste minimization and recycling, and implementing alternative waste management strategies provided they are affordable, effective, and sustainable. Aided by Kyoto mechanisms such as the Clean Development Mechanism (CDM) and Joint Implementation (JI), the total global economic mitigation potential for reducing waste sector emissions in 2030 is estimated to be > 1000 Mt CO2-eq (or 70% of estimated emissions) at costs below 100 US$ t(-1) CO2-eq year(-1). An estimated 20-30% of projected emissions for 2030 can be reduced at negative cost and 30-50% at costs 130 Mt waste year(-1) incinerated at more than 600 plants. Current uncertainties with respect to emissions and mitigation potentials could be reduced by more consistent national definitions, coordinated international data collection, standardized data analysis, field validation of models, and consistent application of life-cycle assessment tools inclusive of fossil fuel offsets.

  17. Assessment of aflatoxin M1 contamination in pasteurized and UHT milk marketed in central part of Iran.

    Science.gov (United States)

    Fallah, Aziz A

    2010-03-01

    This study was conducted as a screening survey to determine the occurrence of aflatoxin M1 (AFM1) in 225 commercial liquid milk samples composed of pasteurized milk (116 samples) and UHT milk (109 samples) obtained from popular markets in central part of Iran. The competitive enzyme-linked immunosorbent assay method was employed to determine level of the toxin in the samples. Aflatoxin M1 was detected in 151 (67.1%) samples, consisted of 83 (71.5%) pasteurized milk samples (mean: 52.8 ng/l; range: 5.8-528.5 ng/l) and 68 (62.3%) UHT milk samples (mean: 46.4 ng/l; range: 5.6-515.9 ng/l). Considering the US FDA and Iranian national standard limits for AFM1 in milk (500 ng/l), 2 samples (1.7%) of pasteurized and 3 samples (2.7%) of UHT milk had levels above the maximum tolerance limit. However, according to European Commission limit (50 ng/l), this figure increased to 31 (26.7%) and 19 (17.4%) samples for pasteurized and UHT milk, respectively. The results indicated that the contamination of the samples with AFM1 in such a level could be a serious public health problem at the moment. This paper represents the data of the first survey on the occurrence of AFM1 in commercial liquid milk marketed in central part of Iran. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  18. Changes in secondary prevention of coronary artery disease in the post-discharge period over the decade 1997-2007. Results of the Cracovian Program for Secondary Prevention of Ischaemic Heart Disease and Polish parts of the EUROASPIRE II and III surveys.

    Science.gov (United States)

    Pajak, Andrzej; Jankowski, Piotr; Kawecka-Jaszcz, Kalina; Surowiec, Sławomir; Wolfshaut, Renata; Loster, Magdalena; Batko, Katarzyna; Badacz, Leszek; Dubiel, Jacek S; Grodecki, Janusz; Grodzicki, Tomasz; Maciejewicz, Janusz; Mirek-Bryniarska, Ewa; Piotrowski, Wiesław; Smielak-Korombel, Wanda; Tracz, Wiesława

    2009-12-01

    Both in the European and Polish guidelines, the highest priority for preventive cardiology was given to patients with established coronary artery disease (CAD). The Cracovian Program for Secondary Prevention of Ischaemic Heart Disease was introduced in 1996 to assess and improve the quality of clinical care in secondary prevention. Departments of cardiology of five participating hospitals serving the area of the city of Kraków and surrounding districts (former Kraków Voivodship) inhabited by a population of 1 200 000 took part in the surveys. In 1999/2000 and 2006/2007 the same hospitals joined the EUROASPIRE (European Action on Secondary Prevention through Intervention to Reduce Events) II and III surveys. The goal of the EUROASPIRE surveys was to assess to what extent the recommendations of the Joint Task Force of International Scientific Societies were implemented into clinical practice. To compare the quality of secondary prevention in the post-discharge period in Kraków in 1997/1998, 1999/2000 and 2006/2007. Consecutive patients hospitalised from 1 July 1996 to 31 September 1997 (first survey), from 1 March 1998 to 30 March 1999 (second survey), and from 1 April 2005 to 31 July 2006 (third survey) due to acute myocardial infarction, unstable angina or for myocardial revascularisation procedures, below the age of 71 years were identified and then followed up, interviewed and examined 6-18 months after discharge. The number of patients who participated in the follow-up examinations was 418 (78.0%) in the first survey, 427 (82.9%) in the second and 427 (79.1%) in the third survey. The use of cardioprotective medication increased significantly: antiplatelets from 76.1% (1997/1998) to 86.9% (1999/2000) and 90.1% (2006/2007), beta-blockers from 59.1% (1997/1998) to 63.9% (1999/2000) and 87.5% (2006/2007), and ACE inhibitors/sartans from 45.9% (1997/1998) to 79.0% (2006/2007). The proportion of patients taking lipid lowering agents increased from 34.0% (1997

  19. Metallothionein (MT)-III

    DEFF Research Database (Denmark)

    Carrasco, J; Giralt, M; Molinero, A

    1999-01-01

    Metallothionein-III is a low molecular weight, heavy-metal binding protein expressed mainly in the central nervous system. First identified as a growth inhibitory factor (GIF) of rat cortical neurons in vitro, it has subsequently been shown to be a member of the metallothionein (MT) gene family a...

  20. BANANAS III (ARTIC

    African Journals Online (AJOL)

    Fr. Ikenga

    Key words: Cross-Retaliation, Justiciability, EC-Bananas III, Countermeasure. 1. Introduction. The World Trade Organisation (WTO) as an international legal personality regulates the World. Trading System to ensure smooth, free, fair and predictable flow of international trade. It is. “the only International Organisation dealing ...