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Sample records for assessment guidelines quantification

  1. EPA`s program for risk assessment guidelines: Quantification issues

    Energy Technology Data Exchange (ETDEWEB)

    Dourson, M.L. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    The quantitative procedures associated with noncancer risk assessment include reference dose (RfD), benchmark dose, and severity modeling. The RfD, which is part of the EPA risk assessment guidelines, is an estimation of a level that is likely to be without any health risk to sensitive individuals. The RfD requires two major judgments: the first is choice of a critical effect(s) and its No Observed Adverse Effect Level (NOAEL); the second judgment is choice of an uncertainty factor. This paper discusses major assumptions and limitations of the RfD model.

  2. Small Wind Site Assessment Guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, Tim [Advanced Energy Systems LLC, Eugene, OR (United States); Preus, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    Site assessment for small wind energy systems is one of the key factors in the successful installation, operation, and performance of a small wind turbine. A proper site assessment is a difficult process that includes wind resource assessment and the evaluation of site characteristics. These guidelines address many of the relevant parts of a site assessment with an emphasis on wind resource assessment, using methods other than on-site data collection and creating a small wind site assessment report.

  3. [Guideline for integrated geriatric assessment].

    Science.gov (United States)

    Reyes-Morales, Hortensia; Doubova, Svetlana Vladislavovna; García-González, José Juan; Espinosa-Aguilar, Amilcar; Jiménez-Uribe, Rodrigo; Peña-Valdovinos, Abel; Mendoza-Núñez, Víctor Manuel

    2009-01-01

    A clinical practice guideline was developed as a response to the increasing of elderly in Mexican population due to the epidemiological transition; this instrument allows the assessment of health conditions for people from 60 years of age and older, and it can be a tool for helping family physicians and nurses in providing care for the main health problems of this group of age. The guideline for gerontologic assessment includes six principal health priorities in older people (loss of vision, difficulty to hear, falls or problems walking, nutritional disorders, memory difficulties, and sleep disorders); additionally, another four components for assessment are revised (medication use, physical functionality, quality of life, and social support). Simple recommendations for detection, diagnosis and management of these problems in primary care settings are presented. PMID:20141660

  4. 2011 Nutritional Assessment Guidelines : information

    Directory of Open Access Journals (Sweden)

    Lisa Freeman

    2011-05-01

    Full Text Available Careful assessment of nutritional needs of dogs and cats must be taken into consideration in order to maintain optimum health, be part of a treatment regimen for a diseased state, or to maximise the quality of life in all animals. Therefore, the goal of these WSAVA Guidelines is that a nutritional assessment and specific nutritional recommendation be made on every patient on every visit. This will become known as the 5th Vital Assessment (5VA, following the four vital assessments of temperature, pulse, respiration and pain that are already addressed on each patient interaction. Routinely doing a brief screening evaluation of the nutritional status during history taking and the physical examination can be seamlessly performed as part of every patient exam. Nutrition-related risk factors that can be easily identified from the history and physical examination include age (growing or old, suboptimal body condition score (overweight or thin, muscle loss, atypical or homemade diet, medical conditions, or changes in appetite. An extended evaluation would follow, if one or more risk factors is identified on screening. These guidelines provide criteria to evaluate the animal and the diet, as well as key feeding and environmental factors. In addition, recommendations for interpretation, analysis, and action are included so that a plan for optimising the animal's nutritional status can be instituted. Client compliance with nutritional recommendations requires input from the veterinarian, veterinary technicians/nurses, and the hospital staff. A team approach to continuous nutritional education, implementation of appropriate protocols, and focused client communication, utilising these WSAVA Nutritional Guidelines, are key components to reach this 5VA goal.

  5. Guidelines for Camouflage Assessment Using Observers

    NARCIS (Netherlands)

    Ronconi, P.; Jacobs, P.A.M.; Mauer, E.; Huebner, G.; Dotoli, P.; Peak, J.E.; Hepfinger, L.; Balma, R.; Christopher, G.; Fleuriet, J.; Honke, T.

    2007-01-01

    The objective of SCI-095 was to advance alternative techniques for determining the camouflage effectiveness of military systems reliably at reduced cost. SCI-095 produced “Guidelines for Camouflage Assessment Using Observers” which is a standardized methodology for observerbased tests and statistica

  6. Assessment of the cortisol awakening response: Expert consensus guidelines.

    Science.gov (United States)

    Stalder, Tobias; Kirschbaum, Clemens; Kudielka, Brigitte M; Adam, Emma K; Pruessner, Jens C; Wüst, Stefan; Dockray, Samantha; Smyth, Nina; Evans, Phil; Hellhammer, Dirk H; Miller, Robert; Wetherell, Mark A; Lupien, Sonia J; Clow, Angela

    2016-01-01

    The cortisol awakening response (CAR), the marked increase in cortisol secretion over the first 30-45 min after morning awakening, has been related to a wide range of psychosocial, physical and mental health parameters, making it a key variable for psychoneuroendocrinological research. The CAR is typically assessed from self-collection of saliva samples within the domestic setting. While this confers ecological validity, it lacks direct researcher oversight which can be problematic as the validity of CAR measurement critically relies on participants closely following a timed sampling schedule, beginning with the moment of awakening. Researchers assessing the CAR thus need to take important steps to maximize and monitor saliva sampling accuracy as well as consider a range of other relevant methodological factors. To promote best practice of future research in this field, the International Society of Psychoneuroendocrinology initiated an expert panel charged with (i) summarizing relevant evidence and collective experience on methodological factors affecting CAR assessment and (ii) formulating clear consensus guidelines for future research. The present report summarizes the results of this undertaking. Consensus guidelines are presented on central aspects of CAR assessment, including objective control of sampling accuracy/adherence, participant instructions, covariate accounting, sampling protocols, quantification strategies as well as reporting and interpreting of CAR data. Meeting these methodological standards in future research will create more powerful research designs, thus yielding more reliable and reproducible results and helping to further advance understanding in this evolving field of research. PMID:26563991

  7. Guidelines and Ethical Considerations for Assessment Center Operations: International Task Force on Assessment Center Guidelines.

    Science.gov (United States)

    Public Personnel Management, 2000

    2000-01-01

    This update of the International Personnel Management Association's guidelines for organizational psychologists, human resource management specialists, and others addresses elements of assessment centers, policy statements, assessor training, informed participation, and participants' rights. (SK)

  8. Guidelines for Camouflage Assessment Using Observers

    OpenAIRE

    Ronconi, P.; Jacobs, P.A.M.; Mauer, E.; Huebner, G.; Dotoli, P.; Peak, J.E.; Hepfinger, L.; Balma, R.; Christopher, G.; Fleuriet, J.; Honke, T.

    2007-01-01

    The objective of SCI-095 was to advance alternative techniques for determining the camouflage effectiveness of military systems reliably at reduced cost. SCI-095 produced “Guidelines for Camouflage Assessment Using Observers” which is a standardized methodology for observerbased tests and statistical analysis. A comparative trial concluded that following the recommended procedures as described in this standardized methodology and with careful attention to experimental setup, produces consiste...

  9. 15 CFR 990.52 - Injury assessment-quantification.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Injury assessment-quantification. 990... REGULATIONS NATURAL RESOURCE DAMAGE ASSESSMENTS Restoration Planning Phase § 990.52 Injury assessment... extent of injury to a natural resource, with subsequent translation of that adverse change to a...

  10. Guidelines for Assessment of and Intervention With Persons With Disabilities

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    The goal of these "Guidelines for Assessment of and Intervention With Persons With Disabilities" is to help psychologists conceptualize and implement more effective, fair, and ethical psychological assessments and interventions with persons with disabilities. The guidelines provide suggestions on ways psychologists can make their practices more…

  11. Guidelines for rating Global Assessment of Functioning (GAF

    Directory of Open Access Journals (Sweden)

    Aas IH Monrad

    2011-01-01

    Full Text Available Abstract Background Global Assessment of Functioning (GAF is a scoring system for the severity of illness in psychiatry. It is used clinically in many countries, as well as in research, but studies have shown several problems with GAF, for example concerning its validity and reliability. Guidelines for rating are important. The present study aimed to identify the current status of guidelines for rating GAF, and relevant factors and gaps in knowledge for the development of improved guidelines. Methods A thorough literature search was conducted. Results Few studies of existing guidelines have been conducted; existing guidelines are short; and rating has a subjective element. Seven main categories were identified as being important in relation to further development of guidelines: (1 general points about guidelines for rating GAF; (2 introduction to guidelines, with ground rules; (3 starting scoring at the top, middle or bottom level of the scale; (4 scoring for different time periods and of different values (highest, lowest or average; (5 the finer grading of the scale; (6 different guidelines for different conditions; and (7 different languages and cultures. Little information is available about how rules for rating are understood by different raters: the final score may be affected by whether the rater starts at the top, middle or bottom of the scale; there is little data on which value/combination of GAF values to record; guidelines for scoring within 10-point intervals are limited; there is little empirical information concerning the suitability of existing guidelines for different conditions and patient characteristics; and little is known about the effects of translation into different languages or of different cultural understanding. Conclusions Few studies have dealt specifically with guidelines for rating GAF. Current guidelines for rating GAF are not comprehensive, and relevant points for new guidelines are presented. Theoretical and

  12. Life Cycle Assessment Guideline for Protection Relay : 615 series

    OpenAIRE

    Liimatainen, Viivi

    2012-01-01

    This thesis is made for ABB Oy, Medium Voltage Products in Vaasa. The main goal of the thesis is to make Life Cycle Assessment (LCA) guideline for protection and control relay product families because the earlier made LCA studies are not valid anymore and the guideline, LCA tool and database are not up-to-date. During the new LCA guideline process product family 615 series LCA study is carried out as an example. The LCA study is based on ISO 14040 standard series and the guideline so call...

  13. Collaborative framework for PIV uncertainty quantification: comparative assessment of methods

    International Nuclear Information System (INIS)

    A posteriori uncertainty quantification of particle image velocimetry (PIV) data is essential to obtain accurate estimates of the uncertainty associated with a given experiment. This is particularly relevant when measurements are used to validate computational models or in design and decision processes. In spite of the importance of the subject, the first PIV uncertainty quantification (PIV-UQ) methods have been developed only in the last three years. The present work is a comparative assessment of four approaches recently proposed in the literature: the uncertainty surface method (Timmins et al 2012), the particle disparity approach (Sciacchitano et al 2013), the peak ratio criterion (Charonko and Vlachos 2013) and the correlation statistics method (Wieneke 2015). The analysis is based upon experiments conducted for this specific purpose, where several measurement techniques are employed simultaneously. The performances of the above approaches are surveyed across different measurement conditions and flow regimes. (paper)

  14. Peak load arrangements : Assessment of Nordel guidelines

    Energy Technology Data Exchange (ETDEWEB)

    2009-07-01

    Two Nordic countries, Sweden and Finland, have legislation that empowers the TSO to acquire designated peak load resources to mitigate the risk for shortage situations during the winter. In Denmark, the system operator procures resources to maintain a satisfactory level of security of supply. In Norway the TSO has set up a Regulation Power Option Market (RKOM) to secure a satisfactory level of operational reserves at all times, also in winter with high load demand. Only the arrangements in Finland and Sweden fall under the heading of Peak Load Arrangements defined in Nordel Guidelines. NordREG has been invited by the Electricity Market Group (EMG) to evaluate Nordel's proposal for 'Guidelines for transitional Peak Load Arrangements'. The EMG has also financed a study made by EC Group to support NordREG in the evaluation of the proposal. The study has been taken into account in NordREG's evaluation. In parallel to the EMG task, the Swedish regulator, the Energy Markets Inspectorate, has been given the task by the Swedish government to investigate a long term solution of the peak load issue. The Swedish and Finnish TSOs have together with Nord Pool Spot worked on finding a harmonized solution for activation of the peak load reserves in the market. An agreement accepted by the relevant authorities was reached in early January 2009, and the arrangement has been implemented since 19th January 2009. NordREG views that the proposed Nordel guidelines have served as a starting point for the presently agreed procedure. However, NordREG does not see any need to further develop the Nordel guidelines for peak load arrangements. NordREG agrees with Nordel that the market should be designed to solve peak load problems through proper incentives to market players. NordREG presumes that the relevant authorities in each country will take decisions on the need for any peak load arrangement to ensure security of supply. NordREG proposes that such decisions should be

  15. Personality Assessment with Adolescents: Challenges and Guidelines

    Science.gov (United States)

    Crespi, Tony D.; Politikos, Natalie N.

    2008-01-01

    Approximately 4.5 to 6.3 million youth experience serious emotional disturbances. Unfortunately, many of them have unmet mental health needs. Tools used in personality assessment can offer unparalleled assistance in diagnosis, and assist in designing appropriate interventions. Unfortunately, not all psychologists embrace personality assessment as…

  16. Evaluation process of global environmental impact: assessment guidelines

    International Nuclear Information System (INIS)

    In developed and developing countries, the EIA (Environmental Impact Assessment) is becoming mandatory for the approval of Industrial projects and projects of Environmental hazards. The approving authority of each country has its own guidelines to get projects approved and make project proponents responsible to submit Environmental Impact Statement for the its detailed assessment. In this paper authors have studied an existing EIA Global guidelines and its evaluation process of altogether 40 countries from four continents, Asia, Pacific/Middle East, Europe, Australia and America/Canada. This evaluation process is recorded in the tabulation form and it has been formulated stage wise in which stage one highlights the inception of EIA guidelines of each country and stage two and three gives implementation process. The inception stage of guidelines gives an idea that when EIA was started and an implementation stages provide all information that when EIA become a part of legislation that provide an opportunity to the reader to understand the decision making process for project approvals. The main objective of writing EIA guidelines is to monitor the sustain ability of various types of the projects under different sectoral guidelines, therefore Projects related with different Sectors have been chosen and a detailed record in tabulation form gives an idea to understand the interaction of these guidelines. To make this paper more comprehensive, authors have gone thorough the sectoral guidelines of altogether 64 countries and studied 21 sector oriented project fields. These are of Agriculture/Irrigation, Biodiversity, Coastal/Marine, Community Participation, Extractive industries, Fisheries, Forestry, Hazard Risk, Health, Human settlement, Industry, Multi sectorial, Ports and Harbors, Power, refugees/resettlement, Social, Strategies/Planning, Tourism/Recreational, transportation, Waste Pollution and Wetlands/Water resources. (author)

  17. A critical assessment of indentation-based ductile damage quantification

    International Nuclear Information System (INIS)

    This paper scrutinizes the reliability of indentation-based damage quantification, frequently used by many industrial and academic researchers. In this methodology, damage evolution parameters for continuum damage models are experimentally measured by probing the deformation-induced degradation of either hardness or indentation modulus. In this critical assessment the damage evolution in different sheet metals was investigated using this indentation approach, whereby the obtained results were verified by other experimental techniques (scanning electron microscopy, X-ray microtomography and highly sensitive density measurements), and by finite element simulations. This extensive experimental-numerical assessment reveals that the damage-induced degradation of both hardness and modulus is at least partially, but most likely completely, masked by other deformation-induced microstructural mechanisms (e.g. grain shape change, strain hardening, texture development, residual stresses and indentation pile-up). It is therefore concluded that hardness-based or modulus-based damage quantification methods are intrinsically flawed and should not be used for the determination of a damage parameter.

  18. Quantification of Human Movement for Assessment in Automated Exercise Coaching

    CERN Document Server

    Hagler, Stuart; Bajczy, Ruzena; Pavel, Misha

    2016-01-01

    Quantification of human movement is a challenge in many areas, ranging from physical therapy to robotics. We quantify of human movement for the purpose of providing automated exercise coaching in the home. We developed a model-based assessment and inference process that combines biomechanical constraints with movement assessment based on the Microsoft Kinect camera. To illustrate the approach, we quantify the performance of a simple squatting exercise using two model-based metrics that are related to strength and endurance, and provide an estimate of the strength and energy-expenditure of each exercise session. We look at data for 5 subjects, and show that for some subjects the metrics indicate a trend consistent with improved exercise performance.

  19. Guidelines for assessment of work disability: An international survey

    NARCIS (Netherlands)

    Boer, W.E.L. de; Rijkenberg, A.M.; Donceel, P.

    2011-01-01

    Background: Assessments of long-term work disability are carried out by social insurance physicians (SIPs) and are little supported with evidence or instruments. Guidelines are hardly ever used in social insurance medicine. Developments in social insurance medicine might be slow as insurance is diff

  20. Salt contamination assessment and remediation guidelines

    International Nuclear Information System (INIS)

    Environmental impacts associated with excess salt in oil and surface water or groundwater (a frequent occurrence in oil and gas production) may be manifested as degradation of soil chemical or physical properties, impaired vegetable growth and degraded surface or groundwater quality. Spill prevention is by far the most effective and most efficient way of avoiding these adverse effects and the attendant remediation costs. However, when spills do occur effective response, based on a comprehensive understanding of impacts, salt movements and remediation procedures can mitigate the adverse environmental effects. This guide is designed to assist those involved in the prevention, assessment, remediation and management of salt-contaminated sites. It summarizes the regulatory requirements in Alberta, including salt remediation objectives, and provides an overview of salt spill problems and effective site assessment and remediation procedures. Background information on the sources of salt, the movement of salt in soil and groundwater, and the adverse effects of salt on soil, vegetation and groundwater is provided in an appendix attached to the Guide. A selected bibliography and a glossary of terms are also included. 42 refs., tabs., figs

  1. Assessment of cumulative evidence on genetic associations: Interim guidelines

    OpenAIRE

    Ioannidis, John; Boffetta, Paolo; Little, Julian; O'Brien, Thomas; Uitterlinden, André; Vineis, Paolo; Balding, David; Chokkalingam, Anand; Dolan, Siobhan; Flanders, Dana; Higgins, Julian; McCarthy, Mark; McDermott, David; Page, Grier; Rebbeck, Timothy

    2008-01-01

    textabstractEstablished guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility...

  2. 77 FR 45350 - Notice of Availability of Microbial Risk Assessment Guideline: Pathogenic Microorganisms With...

    Science.gov (United States)

    2012-07-31

    ... document for public comment in July, 2011(76 FR 44586). EPA received two public comments--one from a member... AGENCY Notice of Availability of Microbial Risk Assessment Guideline: Pathogenic Microorganisms With... Assessment Guideline: Pathogenic Microorganisms with Focus on Food and Water (MRA Guideline). The...

  3. Expert validation of fit-for-purpose guidelines for designing programmes of assessment.

    NARCIS (Netherlands)

    Dijkstra, J.; Galbraith, R.; Hodges, B.D.; McAvoy, P.A.; McCrorie, P.; Southgate, L.J.; Vleuten, C.P.M. van der; Wass, V.; Schuwirth, L.W.

    2012-01-01

    ABSTRACT: BACKGROUND: An assessment programme, a purposeful mix of assessment activities, is necessary to achieve a complete picture of assessee competence. High quality assessment programmes exist, however, design requirements for such programmes are still unclear. We developed guidelines for desig

  4. Assessment methods for angiogenesis and current approaches for its quantification.

    Science.gov (United States)

    AlMalki, Waleed Hassan; Shahid, Imran; Mehdi, Abeer Yousaf; Hafeez, Muhammad Hassan

    2014-01-01

    Angiogenesis is a physiological process which describes the development of new blood vessels from the existing vessels. It is a common and the most important process in the formation and development of blood vessels, so it is supportive in the healing of wounds and granulation of tissues. The different assays for the evaluation of angiogenesis have been described with distinct advantages and some limitations. In order to develop angiogenic and antiangiogenic techniques, continuous efforts have been resulted to give animal models for more quantitative analysis of angiogenesis. Most of the studies on angiogenic inducers and inhibitors rely on various models, both in vitro, in vivo and in ova, as indicators of efficacy. The angiogenesis assays are very much helpful to test efficacy of both pro- and anti- angiogenic agents. The development of non-invasive procedures for quantification of angiogenesis will facilitate this process significantly. The main objective of this review article is to focus on the novel and existing methods of angiogenesis and their quantification techniques. These findings will be helpful to establish the most convenient methods for the detection, quantification of angiogenesis and to develop a novel, well tolerated and cost effective anti-angiogenic treatment in the near future. PMID:24987169

  5. Spatial differentiation in life cycle impact assessment - the EDIP-2003 methodology. Guidelines from the Danish EPA

    DEFF Research Database (Denmark)

    Hauschild, Michael Zwicky; Potting, José

    Guideline on the accordance between the environmental impact predicted in the life cycle assessment and the expected occurrence of actual impact.......Guideline on the accordance between the environmental impact predicted in the life cycle assessment and the expected occurrence of actual impact....

  6. Guidelines for assessing the knowledge management maturity of organizations

    Directory of Open Access Journals (Sweden)

    C. J. Kruger

    2007-11-01

    Full Text Available In a recent article Kruger and Snyman hypothesized that progressions in knowledge management maturity (from a strategic perspective are directly related to an increased ability to speed up the strategic cycle of imitation, consolidation and innovation. The arguments proposed, however, neglected to supply the reader with a practical toolkit or even a roadmap (a time-related matrix, or questionnaire to successfully measure succession in knowledge management maturity. This article builds on the previous one and proposes a questionnaire consisting of six sections, containing 101 descriptive questions, to enable organizations to test and assess their knowledge management maturity empirically. The development of an instrument to measure knowledge management maturity required adhering to a research design that combined theoretical propositions with practical experimentation. As a point of departure, a knowledge management maturity matrix consisting of seven maturity levels was formulated. All questions contained within the matrix were benchmarked against a survey questionnaire developed by the public management service of the OECD (PUMA and were also pre-tested and validated. This process of refinement led to the formulation of the Knowledge Management Maturity Questionnaire. To avoid any taint of this research being based only on theoretical propositions, the questionnaire was tested by 178 master students of the University of Pretoria, South Africa, in nine different industries. The proposed questionnaire provides a bridge between theoretical propositions and practical usability, not only enabling knowledge management practitioners to assess the level of knowledge management maturity reached successfully but, more importantly, also serving as a guideline to institutionalize further and future knowledge management endeavours.

  7. Comparative assessment of bioanalytical method validation guidelines for pharmaceutical industry.

    Science.gov (United States)

    Kadian, Naveen; Raju, Kanumuri Siva Rama; Rashid, Mamunur; Malik, Mohd Yaseen; Taneja, Isha; Wahajuddin, Muhammad

    2016-07-15

    The concepts, importance, and application of bioanalytical method validation have been discussed for a long time and validation of bioanalytical methods is widely accepted as pivotal before they are taken into routine use. United States Food and Drug Administration (USFDA) guidelines issued in 2001 have been referred for every guideline released ever since; may it be European Medical Agency (EMA) Europe, National Health Surveillance Agency (ANVISA) Brazil, Ministry of Health and Labour Welfare (MHLW) Japan or any other guideline in reference to bioanalytical method validation. After 12 years, USFDA released its new draft guideline for comments in 2013, which covers the latest parameters or topics encountered in bioanalytical method validation and approached towards the harmonization of bioanalytical method validation across the globe. Even though the regulatory agencies have general agreement, significant variations exist in acceptance criteria and methodology. The present review highlights the variations, similarities and comparison between bioanalytical method validation guidelines issued by major regulatory authorities worldwide. Additionally, other evaluation parameters such as matrix effect, incurred sample reanalysis including other stability aspects have been discussed to provide an ease of access for designing a bioanalytical method and its validation complying with the majority of drug authority guidelines. PMID:27179186

  8. Health impact assessment: A comparison of 45 local, national, and international guidelines

    International Nuclear Information System (INIS)

    This article provides a comparison of health impact assessment (HIA) guidelines from around the world and for multiple geographic scales. We identify commonalities and differences within HIA guides to discuss the plausibility of consensus guidelines and to inform guideline development. The practice of HIA has grown over the last two decades with a concurrent growth of HIA guides. This study expands on earlier review work and includes guides published since 2007 (Mindell, Boltong and Forde, 2008). From April 2010 to October 2011, 45 HIA guides were identified through an internet search and review of previous research. Common characteristics, key features, and the HIA process were analyzed. The 45 documents recommended similar but not identical processes for conducting HIAs. These analyses suggest that guidelines for HIAs are similar in many areas of the world and that new HIA practitioners can use these findings to inform their approach. Further discussion is needed to determine if the approaches established in these guidelines are followed and if one set of common guidelines could be written for use in numerous countries and regions. - Highlights: ► We analyze 45 health impact assessment (HIA) guidelines worldwide. ► We examine similarities and unique attributes of each guideline. ► We discuss the advantages and disadvantages of developing consensus guidelines. ► Identifying additional guidelines aides in future HIA work and evaluation.

  9. A Bayesian belief nets based quantification method of qualitative software reliability assessment for PSA

    International Nuclear Information System (INIS)

    Current reliability assessments of safety critical software embedded in the digital systems in nuclear power plants are based on the rule-based qualtitative assessment methods. But practical needs require the quantitative features of software reliability for Probabilistic Safety Assessment (PSA) that is one of important methods being used in assessing the whole safety of nuclear power plant. This paper discusses a Bayesian Belief Nets(BBN) based quantification method that models current qualitative software assessment in formal way and produces quantitative results required for PSA. Commercial Off-The-Shelf(COTS) software dedication process was applied to the discussed BBN based method for evaluating the plausibility of the method in PSA

  10. Optical coherence tomography assessment and quantification of intracoronary thrombus: Status and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Porto, Italo, E-mail: italo.porto@gmail.com [Interventional Cardiology Unit, San Donato Hospital, Arezzo (Italy); Mattesini, Alessio; Valente, Serafina [Interventional Cardiology Unit, Careggi Hospital, Florence (Italy); Prati, Francesco [Interventional Cardiology San Giovanni Hospital, Rome (Italy); CLI foundation (Italy); Crea, Filippo [Department of Cardiovascular Sciences, Catholic University of the Sacred Heart, Rome (Italy); Bolognese, Leonardo [Interventional Cardiology Unit, San Donato Hospital, Arezzo (Italy)

    2015-04-15

    Coronary angiography is the “golden standard” imaging technique in interventional cardiology and it is still widely used to guide interventions. A major drawback of this technique, however, is that it is inaccurate in the evaluation and quantification of intracoronary thrombus burden, a critical prognosticator and predictor of intraprocedural complications in acute coronary syndromes. The introduction of optical coherence tomography (OCT) holds the promise of overcoming this important limitation, as near-infrared light is uniquely sensitive to hemoglobin, the pigment of red blood cells trapped in the thrombus. This narrative review will focus on the use of OCT for the assessment, evaluation and quantification of intracoronary thrombosis. - Highlights: • Thrombotic burden in acute coronary syndromes Is not adequately evaluated by standard coronary angiography, whereas Optical Coherence Tomography is exquisitely sensitive to the hemoglobin contained in red blood cells and can be used to precisely quantify thrombus. • Both research and clinical applications have been developed using the OCT-based evaluation of thrombus. In particular, whereas precise quantification scores are useful for comparing antithrombotic therapies in randomized trials, both pharmacological and mechanical, the most important practical applications for OCT-based assessment of thrombus are the individuation of culprit lesions in the context of diffuse atheromata in acute coronary syndromes, and the so-called “delayed stenting” strategies. • Improvements in 3D rendering techniques are on the verge of revolutionizing OCT-based thrombus assessment, allowing extremely precise quantification of the thrombotic burden.

  11. Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality.

    Directory of Open Access Journals (Sweden)

    Carmel Jacobs

    Full Text Available BACKGROUND: Consensus statements and clinical practice guidelines are widely available for enhancing the care of cancer patients. Despite subtle differences in their definition and purpose, these terms are often used interchangeably. We systematically assessed the methodological quality of consensus statements and clinical practice guidelines published in three commonly read, geographically diverse, cancer-specific journals. Methods Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal of Clinical Oncology were evaluated. Each publication was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II rigour of development and editorial independence domains. For assessment of transparency of document development, 7 additional items were taken from the Institute of Medicine's standards for practice guidelines and the Journal of Clinical Oncology guidelines for authors of guidance documents. METHODS: Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal of Clinical Oncology were evaluated. Each publication was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II rigour of development and editorial independence domains. For assessment of transparency of document development, 7 additional items were taken from the Institute of Medicine's standards for practice guidelines and the Journal of Clinical Oncology guidelines for authors of guidance documents. FINDINGS: Thirty-four consensus statements and 67 clinical practice guidelines were evaluated. The rigour of development score for consensus statements over the three journals was 32% lower than that of clinical practice guidelines. The editorial independence score was 15% lower for consensus statements than clinical practice

  12. Human DNA quantification and sample quality assessment: Developmental validation of the PowerQuant(®) system.

    Science.gov (United States)

    Ewing, Margaret M; Thompson, Jonelle M; McLaren, Robert S; Purpero, Vincent M; Thomas, Kelli J; Dobrowski, Patricia A; DeGroot, Gretchen A; Romsos, Erica L; Storts, Douglas R

    2016-07-01

    Quantification of the total amount of human DNA isolated from a forensic evidence item is crucial for DNA normalization prior to short tandem repeat (STR) DNA analysis and a federal quality assurance standard requirement. Previous commercial quantification methods determine the total human DNA and total human male DNA concentrations, but provide limited information about the condition of the DNA sample. The PowerQuant(®) System includes targets for quantification of total human and total human male DNA as well as targets for evaluating whether the human DNA is degraded and/or PCR inhibitors are present in the sample. A developmental validation of the PowerQuant(®) System was completed, following SWGDAM Validation Guidelines, to evaluate the assay's specificity, sensitivity, precision and accuracy, as well as the ability to detect degraded DNA or PCR inhibitors. In addition to the total human DNA and total human male DNA concentrations in a sample, data from the degradation target and internal PCR control (IPC) provide a forensic DNA analyst meaningful information about the quality of the isolated human DNA and the presence of PCR inhibitors in the sample that can be used to determine the most effective workflow and assist downstream interpretation. PMID:27206225

  13. Approach to fever assessment in ambulatory cancer patients receiving chemotherapy: a clinical practice guideline

    Science.gov (United States)

    Krzyzanowska, M.K.; Walker-Dilks, C.; Atzema, C.; Morris, A.; Gupta, R.; Halligan, R.; Kouroukis, T.; McCann, K.

    2016-01-01

    Background This guideline was prepared by the Fever Assessment Guideline Development Group, a group organized by the Program in Evidence-Based Care at the request of the Cancer Care Ontario Systemic Treatment Program. The mandate was to develop a standardized approach (in terms of definitions, information, and education) for the assessment of fever in cancer patients receiving chemotherapy. Methods The guideline development methods included a search for existing guidelines, literature searches in medline and embase for systematic reviews and primary studies, internal review by content and methodology experts, and external review by targeted experts and intended users. Results The search identified eight guidelines that had partial relevance to the topic of the present guideline and thirty-eight primary studies. The studies were mostly noncomparative prospective or retrospective studies. Few studies directly addressed the topic of fever except as one among many symptoms or adverse effects associated with chemotherapy. The recommendations concerning fever definition are supported mainly by other existing guidelines. No evidence was found that directly pertained to the assessment of fever before a diagnosis of febrile neutropenia was made. However, some studies evaluated approaches to symptom management that included fever among the symptoms. Few studies directly addressed information needs and resources for managing fever in cancer patients. Conclusions Fever in patients with cancer who are receiving systemic therapy is a common and potentially serious symptom that requires prompt assessment, but currently, evidence to inform best practices concerning when, where, and by whom that assessment is done is very limited.

  14. Playing Around: Benefits, Assessments, and Guidelines for Adolescents' Educational Games.

    Science.gov (United States)

    Clark, Linda Nielsen

    1978-01-01

    Underachieving high school students participated in an English program, in which they could select games or other activities as rewards for academic or social skills mastery specified in a weekly contract. Students' game preferences and teacher guidelines on game use were identified. (SJL)

  15. European clinical guidelines for Tourette syndrome and other tic disorders. Part I: assessment

    DEFF Research Database (Denmark)

    Cath, Danielle C; Hedderly, Tammy; Ludolph, Andrea G;

    2011-01-01

    members. Detailed clinical assessment guidelines of tic disorders and their comorbidities in both children and adults are presented. Screening methods that might be helpful and necessary for specialists' differential diagnosis process are suggested in order to further analyse cognitive abilities...

  16. Sustainability Monitoring and Assessment Routine: Results from pilot applications of the FAO SAFA Guidelines

    OpenAIRE

    Jawtusch, Julia; Schader, Christian; Stolze, Matthias; Baumgart, Lukas; Niggli, Urs

    2013-01-01

    There is currently no common understanding of how to measure sustainability in the food sector. To close this gap, the FAO has developed Guidelines for Sustainability Assessments of Food and Agriculture Systems (SAFA), which were published as a test version in June 2012. The Guidelines describe about 60 sustainability objectives, which are classified into 20 themes and four dimensions: Good governance, Environmental integrity, Economic resilience, Social well-being, as well as assessment proc...

  17. ASCOT guidelines revised 1996 edition. Guidelines for organizational self-assessment of safety culture and for reviews by the assessment of safety culture in organizations team

    International Nuclear Information System (INIS)

    In order to properly assess safety culture, it is necessary to consider the contribution of all organizations which have an impact on it. Therefore, while assessing the safety culture in an operating organization it is necessary to address at least its interfaces with the local regulatory agency, utility corporate headquarters and supporting organizations. These guidelines are primarily intended for use by any organization wishing to conduct a self-assessment of safety culture. They should also serve as a basis for conducting an international peer review of the organization's self-assessment carried out by an ASCOT (Assessment of Safety Culture in Organizations Team) mission

  18. Assessment of Cancer-Related Fatigue: Role of the Oncology Nurse in Translating NCCN Assessment Guidelines into Practice

    OpenAIRE

    Piper, Barbara F.; Borneman, Tami; Sun, Virginia Chih-Yi; Koczywas, Marianna; Uman, Gwen; Ferrell, Betty; James, Raysenia L.

    2008-01-01

    Despite the availability of the National Comprehensive Cancer Network’s (NCCN) evidence-based practice guidelines for the assessment and management of Cancer-Related Fatigue (CRF), assessment of CRF still is not routinely performed at many institutions and oncology practice settings. Numerous patient-, provider-, and system-related barriers exist that hinder the translation of these guidelines into practice by oncology nurses and other health care providers. Oncology nurses can play vital rol...

  19. Qualitative assessment of agritourism safety guidelines: a demonstration project.

    Science.gov (United States)

    Tutor-Marcom, Robin; Greer, Annette; Clay, Maria; Ellis, Tammy; Thompson, Tami; Adam-Samura, Esther Seisay

    2013-01-01

    In 2007, the National Children's Center for Rural and Agricultural Health and Safety (NCCRAHS) published Agritourism Health and Safety Guidelines for Children to provide helpful recommendations for protecting the health and safety of children visiting agritourism farms. Supplement A: Policies and Procedures Guide and Supplement B: Worksite Guide were subsequently published in 2009 and provided agritourism farms with checklists to use in reviewing, planning, and implementing their own health and safety practices. In order to better understand what would be required of a farm wishing to implement the guidelines using Supplements A and B, the North Carolina Agromedicine Institute conducted a single-family farm demonstration project with support from the NCCRAHS. The aims of the project were to (1) determine child health and safety risks associated with an existing agritourism farm; (2) determine the cost of making improvements necessary to reduce risks; and (3) use project findings to motivate other agritourism farms, Cooperative Extension agents, and agritourism insurers to adopt or recommend Agritourism Health and Safety Guidelines for Children for their own farms or farms with which they work. At the conclusion of the study, the target farm was in compliance with an average of 86.9% of items in Supplements A and B. Furthermore, 89% of individuals self-identifying as farmers or farm workers and 100% of Cooperative Extension agents and agritourism insurers attending an end-of-project workshop indicated their intent to adopt or recommend Agritourism Health and Safety Guidelines for Children for their own farms or farms with which they work. PMID:23540301

  20. Assessing Pulmonary Perfusion in Emphysema Automated Quantification of Perfused Blood Volume in Dual-Energy CTPA

    OpenAIRE

    Meinel, Felix G.; Graef, Anita; Thieme, Sven F.; Bamberg, Fabian; Schwarz, Florian; Sommer, Wieland; Helck, Andreas D.; Neurohr, Claus; Reiser, Maximilian F.; Johnson, Thorsten R. C.

    2013-01-01

    Objectives: The objective of this study was to determine whether automated quantification of lung perfused blood volume (PBV) in dual-energy computed tomographic pulmonary angiography (DE-CTPA) can be used to assess the severity and regional distribution of pulmonary hypoperfusion in emphysema. Materials and Methods: We retrospectively analyzed 40 consecutive patients (mean age, 67 13] years) with pulmonary emphysema, who have no cardiopulmonary comorbidities, and a DE-CTPA negative for pulmo...

  1. Assessment of Probiotic Viability during Cheddar Cheese Manufacture and Ripening Using Propidium Monoazide-PCR Quantification

    OpenAIRE

    Desfossés-Foucault, Émilie; Dussault-Lepage, Véronique; Le Boucher, Clémentine; Savard, Patricia; LaPointe, Gisèle; Roy, Denis

    2012-01-01

    The use of a suitable food carrier such as cheese could significantly enhance probiotic viability during storage. The main goal of this study was to assess viability of commercial probiotic strains during Cheddar cheesemaking and ripening (4–6 months) by comparing the efficiency of microbiological and molecular approaches. Molecular methods such as quantitative PCR (qPCR) allow bacterial quantification, and DNA-blocking molecules such as propidium monoazide (PMA) select only the living cells’...

  2. ASCOT guidelines. Guidelines for organizational self-assessment of safety culture and for reviews by the Assessment of Safety Culture in Organizations Team

    International Nuclear Information System (INIS)

    These guidelines describe an approach used in conducting an Assessment of Safety Culture in Organizations Team (ASCOT) review. They are intended to assist the team members in conducting their reviews and at the same time provide guidance to hosts preparing to receive an ASCOT review. They may also be used by any organization wishing to conduct their own self-assessment of safety culture, independent of an ASCOT review

  3. Application of quantification theory in risk assessment of mine flooding

    Institute of Scientific and Technical Information of China (English)

    WANG Lian-guo; MIAO Xie-xing; DONG Xu; WU Yu

    2008-01-01

    Hundreds of mine flooding accidents have occurred in China since the 1950s. These flooding accidents result in sub-merged working faces, even entire coal mines, leading to tremendous economic losses. It is reported that among 601 state-owned mines in China, 285 mines are exposed to water-inrush risks. The water pressure is becoming larger and larger with the increase of mining depth, leading to an increase of water-inrush hazards. Only when the risk of mine flooding is predicted in a reasonable manner, can we take timely and effective measures to prevent mine flooding from taking place. In our investigation quantifica-tion(II) theory is used to study the risk prediction problem about mine flooding. By investigating the main factors which affect mine flooding, eight risk assessment items have been identified. The extent of risk is classified into 4 grades. Given the data from differ-ent periods in the Feicheng mining area, a prediction model for the risk of mine flooding is established. The test analysis indicates a model correlation coefficient of 0.97 and the incidence of discrimination is as high as 97.37%, which implies that the effect of the model is quite satisfactory. With the help of computers, this method can be widely applied.

  4. Assessment of methods for organic and inorganic carbon quantification in carbonate-containing Mediterranean soils

    Science.gov (United States)

    Apesteguia, Marcos; Virto, Iñigo; Plante, Alain

    2014-05-01

    Quantification of soil organic matter (SOM) stocks and fluxes continues to be an important endeavor in assessments of soil quality, and more broadly in assessments of ecosystem functioning. The quantification of SOM in alkaline, carbonate-containing soils, such as those found in Mediterranean areas, is complicated by the need to differentiate between organic carbon (OC) and inorganic carbon (IC), which continues to present methodological challenges. Acidification is frequently used to eliminate carbonates prior to soil OC quantification, but when performed in the liquid phase, can promote the dissolution and loss of a portion of the OC. Acid fumigation (AF) is increasingly preferred for carbonate removal, but its effectiveness is difficult to assess using conventional elemental and isotopic analyses. In addition, the potential effects of AF on SOM are not well characterized. The objective of the current study was to apply a multi-method approach to determine the efficacy of carbonate removal by AF and its effects on the residual SOM. We selected a set of 24 surface agricultural soils representing a large range of textures, SOM contents and presumed carbonate contents. For each soil, OC was determined using wet combustion (Walkley-Black) and IC was determined using the calcimeter method. Samples were then subjected to elemental (total C) and isotopic (δ13C) analyses by dry combustion using a Costech autoanalyzer coupled to a Thermo Finnigan Delta Plus isotope ratio mass spectrometer (IRMS) before and after AF. IC was equated to total C determined after fumigation, and OC was estimated as the different in total C before and after AF. Samples were also subjected to ramped oxidation using a Netzsch STA109 PC Luxx thermal analyzer coupled to a LICOR 820A infrared gas analyzer (IRGA). Quantification of OC was performed using evolved gas analysis of CO2 (CO2-EGA) in the exothermic region 200-500° C associated with organic matter combustion. IC was quantified by CO2-EGA

  5. Preliminary Guideline for the High Temperature Structure Integrity Assessment Procedure Part II. High Temperature Structural Integrity Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Han; Kim, J. B.; Lee, H. Y.; Park, C. G.; Joo, Y. S.; Koo, G. H.; Kim, S. H

    2007-02-15

    A high temperature structural integrity assessment belongs to the Part II of a whole preliminary guideline for the high temperature structure. The main contents of this guideline are the evaluation procedures of the creep-fatigue crack initiation and growth in high temperature condition, the high temperature LBB evaluation procedure, and the inelastic evaluations of the welded joints in SFR structures. The methodologies for the proper inelastic analysis of an SFR structures in high temperatures are explained and the guidelines of inelastic analysis options using ANSYS and ABAQUS are suggested. In addition, user guidelines for the developed NONSTA code are included. This guidelines need to be continuously revised to improve the applicability to the design and analysis of the SFR structures.

  6. H2S release rate assessment guidelines and audit forms

    International Nuclear Information System (INIS)

    Development of a process to evaluate and calculate potential hydrogen sulfide release has been recommended by the Canadian Association of Petroleum Producers' Drilling and Completion Committee, and the Alberta Energy and Utilities Board. To facilitate the process, CAPP has released guidelines describing a methodology and standard for the industry to calculate the potential hydrogen sulfide release rates of a well, and a standardized format for the documentation and retention of data. The Guidelines describe a four-step process, with each step having an increasing degree of complexity. Step One describes the zone hydrogen sulfide exclusion area maps, defining when reporting is to be used (based on well location and distance from inhabited areas). Step Two provides details of the recommended method for determining hydrogen sulfide release through a data search process. Step Three consists of a series of instructions in the use of geologic analogs, data editing and wellbore design to further refine the cumulative hydrogen sulfide release rate. Step Four contains information designed to assist in detailed geological and reservoir modeling. It is not necessary to use all four steps in all cases. The user, however, is advised to use sound engineering judgement and due diligence in the calculation decisions. Sample calculations are provided for a variety of different situations. Measurement techniques are described in an appendix. A completed example of an audit form is attached. 10 + 6 refs., tabs

  7. EPRG Tier 2 guidelines for the assessment of defects in transmission pipeline girth welds

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, Robert Bob [BMT Flett Technolohy, Loughborough, (United Kingdom); Denys, Rudi [Labo Soete, Universiteit Gent, Gent, (Belgium); Knauf, Gerhard [Salzgitter Mannesmann Forschung, Duisburg, (Germany); Zarea, Mures [GDF SUEZ, Saint-Denis la Plaine, (France)

    2010-07-01

    The guidelines governing the development of pipeline technology need to be updated with the increasing use of automated ultrasonic inspection and higher strength pipeline. This paper described proposed revisions to Tier 2 of the European Pipeline Research Group (EPRG) weld defect guidelines. Three particular aspects were studied: the extension of the guidelines to include grade L555 (X80) material, the assessment of surface-breaking defects with height up to 5 mm and the assessment of multiple co-planar defects. Experimental studies were carried out to define the required levels of weld metal yield strength for the safe application of the guidelines. The results of 560 curved wide plate tests showed that the Tier 2 limits prevent failure at remote strain below 0.5% and require higher weld quality. Following these results, the defect interaction criteria have been made less restrictive.

  8. The development of assessment and remediation guidelines for contaminated soils, a review of the science

    International Nuclear Information System (INIS)

    Soil contamination is no longer restricted to isolated incidents and locations; it is a general and contentious problem. However, the problem is complex, starting with the very definition of what level and type of contamination is unacceptable. A myriad of regulatory and de facto guidelines have emerged, and they are extremely fragmented, inconsistent and incomplete. This review attempts to summarize the historical development of assessment and remediation guidelines, to highlight the unique difficulties of the problem, and then to discuss the scientific information that exists and that is needed to improve guidelines. This is an unlimited scope for research on this subject. (author)

  9. British Association for Sexual Health and HIV: framework for guideline development and assessment.

    Science.gov (United States)

    Kingston, Margaret; Radcliffe, Keith; Cousins, Darren; Fifer, Helen; FitzGerald, Mark; Grover, Deepa; Hardman, Sarah; Higgins, Stephen; Rayment, Michael; Sullivan, Ann

    2016-03-01

    SummaryThe Clinical Effectiveness Group of the British Association for Sexual Health has updated their methodology for the production of national guidelines for the management of sexually transmitted infections and related conditions. The main changes are the adoption of the GRADE system for assessing evidence and making recommendations and the introduction of a specific Conflict of Interests policy for Clinical Effectiveness Group members and guideline authors. This new methodology has been piloted during the production of the 2015 British Association for Sexual Health & HIV guideline on the management of syphilis. PMID:26464503

  10. Assessment of the real-time PCR and different digital PCR platforms for DNA quantification.

    Science.gov (United States)

    Pavšič, Jernej; Žel, Jana; Milavec, Mojca

    2016-01-01

    Digital PCR (dPCR) is beginning to supersede real-time PCR (qPCR) for quantification of nucleic acids in many different applications. Several analytical properties of the two most commonly used dPCR platforms, namely the QX100 system (Bio-Rad) and the 12.765 array of the Biomark system (Fluidigm), have already been evaluated and compared with those of qPCR. However, to the best of our knowledge, direct comparison between the three of these platforms using the same DNA material has not been done, and the 37 K array on the Biomark system has also not been evaluated in terms of linearity, analytical sensitivity and limit of quantification. Here, a first assessment of qPCR, the QX100 system and both arrays of the Biomark system was performed with plasmid and genomic DNA from human cytomegalovirus. With use of PCR components that alter the efficiency of qPCR, each dPCR platform demonstrated consistent copy-number estimations, which indicates the high resilience of dPCR. Two approaches, one considering the total reaction volume and the other considering the effective reaction size, were used to assess linearity, analytical sensitivity and variability. When the total reaction volume was considered, the best performance was observed with qPCR, followed by the QX100 system and the Biomark system. In contrast, when the effective reaction size was considered, all three platforms showed almost equal limits of detection and variability. Although dPCR might not always be more appropriate than qPCR for quantification of low copy numbers, dPCR is a suitable method for robust and reproducible quantification of viral DNA, and a promising technology for the higher-order reference measurement method. PMID:26521179

  11. Motion corrected LV quantification based on 3D modelling for improved functional assessment in cardiac MRI

    Science.gov (United States)

    Liew, Y. M.; McLaughlin, R. A.; Chan, B. T.; Aziz, Y. F. Abdul; Chee, K. H.; Ung, N. M.; Tan, L. K.; Lai, K. W.; Ng, S.; Lim, E.

    2015-04-01

    Cine MRI is a clinical reference standard for the quantitative assessment of cardiac function, but reproducibility is confounded by motion artefacts. We explore the feasibility of a motion corrected 3D left ventricle (LV) quantification method, incorporating multislice image registration into the 3D model reconstruction, to improve reproducibility of 3D LV functional quantification. Multi-breath-hold short-axis and radial long-axis images were acquired from 10 patients and 10 healthy subjects. The proposed framework reduced misalignment between slices to subpixel accuracy (2.88 to 1.21 mm), and improved interstudy reproducibility for 5 important clinical functional measures, i.e. end-diastolic volume, end-systolic volume, ejection fraction, myocardial mass and 3D-sphericity index, as reflected in a reduction in the sample size required to detect statistically significant cardiac changes: a reduction of 21-66%. Our investigation on the optimum registration parameters, including both cardiac time frames and number of long-axis (LA) slices, suggested that a single time frame is adequate for motion correction whereas integrating more LA slices can improve registration and model reconstruction accuracy for improved functional quantification especially on datasets with severe motion artefacts.

  12. Assessment of current mass spectrometric workflows for the quantification of low abundant proteins and phosphorylation sites

    Directory of Open Access Journals (Sweden)

    Manuel Bauer

    2015-12-01

    Full Text Available The data described here provide a systematic performance evaluation of popular data-dependent (DDA and independent (DIA mass spectrometric (MS workflows currently used in quantitative proteomics. We assessed the limits of identification, quantification and detection for each method by analyzing a dilution series of 20 unmodified and 10 phosphorylated synthetic heavy labeled reference peptides, respectively, covering six orders of magnitude in peptide concentration with and without a complex human cell digest background. We found that all methods performed very similarly in the absence of background proteins, however, when analyzing whole cell lysates, targeted methods were at least 5–10 times more sensitive than directed or DDA methods. In particular, higher stage fragmentation (MS3 of the neutral loss peak using a linear ion trap increased dynamic quantification range of some phosphopeptides up to 100-fold. We illustrate the power of this targeted MS3 approach for phosphopeptide monitoring by successfully quantifying 9 phosphorylation sites of the kinetochore and spindle assembly checkpoint component Mad1 over different cell cycle states from non-enriched pull-down samples. The data are associated to the research article ‘Evaluation of data-dependent and data-independent mass spectrometric workflows for sensitive quantification of proteins and phosphorylation sites׳ (Bauer et al., 2014 [1]. The mass spectrometry and the analysis dataset have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org via the PRIDE partner repository with the dataset identifier PXD000964.

  13. Is biofilm removal properly assessed? Comparison of different quantification methods in a 96-well plate system.

    Science.gov (United States)

    Stiefel, Philipp; Rosenberg, Urs; Schneider, Jana; Mauerhofer, Stefan; Maniura-Weber, Katharina; Ren, Qun

    2016-05-01

    Various methods have been reported to quantify total biofilm or different components of biofilm; however, these methods are often confusedly used, leading to discrepancies and misleading results. In this study, different methods for quantification of biofilm, including those for total biomass, total amount of bacterial cells, viable cell number, and amount of extracellular polymeric substances, were systematically compared in microtiter plates. To evaluate which method is suitable for assessment of biofilm removal and for bacterial killing, biofilm samples were treated with various cleaners possessing removing and/or killing capacities. It was found that most of the methods tested in this study in general exhibited high reproducibility and repeatability. Crystal Violet staining was a simple but reliable method for total biomass quantification. Total bacteria cell numbers could be reliably quantified by the fluorescent DNA-binding dye Acridine Orange. Viable cells could be quantified by either an ATP-based assay or a proliferation assay. Both of these viability methods showed a broad detection range and led to precise measurement. For quantification of proteins in the biofilm, staining with fluorescein isothiocyanate was most suitable. Furthermore, it was revealed that a combination of different methods is required to determine if a cleaner kills or removes biofilm. PMID:26923144

  14. Quality Assessment of Clinical Practice Guidelines Developed by Professional Societies in Turkey

    Science.gov (United States)

    Yaşar, Ilknur; Kahveci, Rabia; Baydar Artantaş, Aylin; Ayhan Başer, Duygu; Gökşin Cihan, Fatma; Şencan, Irfan; Koç, Esra Meltem; Özkara, Adem

    2016-01-01

    Background Clinical practice guidelines (CPGs) are systematically developed statements to assist practitioner and patient decisions about appropriate healthcare for specific clinical circumstances. There is a limited number of studies on guidelines in Turkey. The quality of Ministry of Health guidelines have formerly been assessed whereas there is no information on the other guidelines developed in the country. Aim This study aims to assess the quality of CPGs that are developed by professional societies that work for the health sector in Turkey, and compare the findings with international guidelines. Methodology Professional societies that work for the health sector were determined by using the data obtained from the Ministry of Internal Affairs. Inclusion and exclusion criteria were defined for selecting the CPGs. Guidelines containing recommendations about disease management to the doctors, accessible online, developed within the past 5 years, citing references for recommendations, about the diseases over 1% prevalence according to the “Statistical Yearbook of Turkey 2012” were included in the study. The quality of CPGs were assessed with the AGREE II instrument, which is an internationally recognized tool for this purpose. Four independent reviewers, who did not participate in the development of the selected guidelines and were trained in CPG appraisal, used the AGREE instrument for assessment of the selected guidelines. Findings 47 professional societies were defined which provided access to CPGs in their websites; 3 of them were only open to members so these could not be reached. 8 CPGs from 7 societies were selected from a total of 401 CPGs from 44 societies. The mean scores of the domains of the guidelines which were assessed by the AGREE II tool were; Scope and purpose: 64%, stakeholder involvement: 37.9%, rigour of development: 35.3%, clarity and presentation: 77.9%, applicability: 49.0% and editorial independence: 46.0%. Conclusion This is the first

  15. Quantification of biofilm in microtiter plates: overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci.

    Science.gov (United States)

    Stepanović, Srdjan; Vuković, Dragana; Hola, Veronika; Di Bonaventura, Giovanni; Djukić, Slobodanka; Cirković, Ivana; Ruzicka, Filip

    2007-08-01

    The details of all steps involved in the quantification of biofilm formation in microtiter plates are described. The presented protocol incorporates information on assessment of biofilm production by staphylococci, gained both by direct experience as well as by analysis of methods for assaying biofilm production. The obtained results should simplify quantification of biofilm formation in microtiter plates, and make it more reliable and comparable among different laboratories. PMID:17696944

  16. Guidelines and procedures for the International Code Assessment and Applications Program

    International Nuclear Information System (INIS)

    This document presents the guidelines and procedures by which the International Code Assessment and Applications Program (ICAP) will be conducted. The document summarizes the management structure of the program and the relationships between and responsibilities of the United States Nuclear Regulatory Commission (USNRC) and the international participants. The procedures for code maintenance and necessary documentation are described. Guidelines for the performance and documentation of code assessment studies are presented. An overview of an effort to quantify code uncertainty, which the ICAP supports, is included

  17. PROSPER guidelines: Guidelines for peer review and for plant self-assessment of operational experience feedback process

    International Nuclear Information System (INIS)

    Effective use of operational performance information is an important element in any plant operator's arrangements for enhancing the operational safety of a nuclear power plant (NPP). This has been recognized in the IAEA Safety Fundamental, The Safety of Nuclear Installations (Safety Series No. 110). Under the technical aspects of safety, one of the principles of operation and maintenance is that the operating organization and the regulatory body shall establish complementary programmes to analyse operating experience to ensure that lessons are learned and acted upon. Such experience shall be shared with relevant national and international bodies. The Convention on Nuclear Safety, which entered into force in July 1996, also recognized the importance of operational experience feedback as a tool of high importance for the safety of nuclear plant operation and its further enhancement. It follows that the arrangements and results achieved under the operation experience feedback process in Member States will be covered by the national report under the Convention and will be subject to periodical review. These principles are further expanded in the IAEA Safety Standards Safety of Nuclear Power Plants: Operation (Safety Standard Series No. NS-R-2, year 2000) under the Feedback of The IAEA-led Peer Review of the effectiveness of the Operational Safety Performance Experience Review process (PROSPER) and associated guidelines have been developed to provide advice and assistance to utilities or individual power plants to strengthen and enhance the effectiveness of operational experience programmes in achieving these fundamental objectives. The objectives of the former IAEA Assessment of Significant Safety Events Team (ASSET) service have been expanded to include an evaluation of the effective use of all operating performance information available to the plant (e.g. external operating experience, internal low-level and near miss event reports and other relevant operating

  18. EPa`s program for risk assessment guidelines: Exposure issues

    Energy Technology Data Exchange (ETDEWEB)

    Callahan, M.A. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    Three major issues to be dealt with over the next ten years in the exposure assessment field are: consistency in terminology, the impact of computer technology on the choice of data and modeling, and conceptual issues such as the use of time-weighted averages.

  19. ARN Training Course on Advance Methods for Internal Dose Assessment: Application of Ideas Guidelines

    International Nuclear Information System (INIS)

    Dose assessment in case of internal exposure involves the estimation of committed effective dose based on the interpretation of bioassay measurement, and the assumptions of hypotheses on the characteristics of the radioactive material and the time pattern and the pathway of intake. The IDEAS Guidelines provide a method to harmonize dose evaluations using criteria and flow chart procedures to be followed step by step. The EURADOS Working Group 7 'Internal Dosimetry', in collaboration with IAEA and Czech Technical University (CTU) in Prague, promoted the 'EURADOS/IAEA Regional Training Course on Advanced Methods for Internal Dose Assessment: Application of IDEAS Guidelines' to broaden and encourage the use of IDEAS Guidelines, which took place in Prague (Czech Republic) from 2-6 February 2009. The ARN identified the relevance of this training and asked for a place for participating on this activity. After that, the first training course in Argentina took place from 24-28 August for training local internal dosimetry experts. (authors)

  20. Uncertainty Quantification in the Reliability and Risk Assessment of Generation IV Reactors: Final Scientific/Technical Report

    International Nuclear Information System (INIS)

    The project entitled, 'Uncertainty Quantification in the Reliability and Risk Assessment of Generation IV Reactors', was conducted as a DOE NERI project collaboration between Texas A and M University and The Ohio State University between March 2006 and June 2009. The overall goal of the proposed project was to develop practical approaches and tools by which dynamic reliability and risk assessment techniques can be used to augment the uncertainty quantification process in probabilistic risk assessment (PRA) methods and PRA applications for Generation IV reactors. This report is the Final Scientific/Technical Report summarizing the project.

  1. Uncertainty Quantification in the Reliability and Risk Assessment of Generation IV Reactors: Final Scientific/Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Vierow, Karen; Aldemir, Tunc

    2009-09-10

    The project entitled, “Uncertainty Quantification in the Reliability and Risk Assessment of Generation IV Reactors”, was conducted as a DOE NERI project collaboration between Texas A&M University and The Ohio State University between March 2006 and June 2009. The overall goal of the proposed project was to develop practical approaches and tools by which dynamic reliability and risk assessment techniques can be used to augment the uncertainty quantification process in probabilistic risk assessment (PRA) methods and PRA applications for Generation IV reactors. This report is the Final Scientific/Technical Report summarizing the project.

  2. Baltic Climate Vulnerability Assessment Framework : Introduction and Guidelines

    OpenAIRE

    Hjerpe, Mattias; Wilk, Julie

    2010-01-01

    This Vulnerability Assessment Framework was put together within the project Baltic Challenges and Chances for local and regional development generated by Climate Change financed by the European Regional Development Fund and the Baltic Sea Region Programme 2007-2013. The purpose of the framework is to guide and assist the Target Areas (TA) within the project in mapping and analysing the challenges and chances created by climate change. The Vulnerability exercises have originally been developed...

  3. Quantification of micronuclei in blood lymphocytes of patients exposed to gamma radiation for dose absorbed assessment

    International Nuclear Information System (INIS)

    Dose assessment in an important step to evaluate biological effects as a result of individual exposure to ionizing radiation. The use of cytogenetic dosimetry based on the quantification of micronuclei in lymphocytes is very important to complement physical dosimetry, since the measurement of absorbed dose cannot be always performed. In this research, the quantification of micronuclei was carried out in order to evaluate absorbed dose as a result of radiotherapy with 60Co, using peripheral blood samples from 5 patients with cervical uterine cancer. For this purpose, an aliquot of whole blood from the individual patients was added in culture medium RPMI 1640 supplemented with fetal calf serum and phytohaemagglutinin. The culture was incubated for 44 hours. Henceforth, cytochalasin B was added to block the dividing lymphocytes in cytokinesis. The culture was returned to the incubator for further of 28 hours. Thus, cells were harvested, processed and analyzed. Values obtained considering micronuclei frequency after pelvis irradiation with absorption of 0,08 Gy and 1,8 Gy were, respectively, 0,0021 and 0,052. These results are in agreement with some recent researches that provided some standard values related to micronuclei frequency induced by gamma radiation exposure in different exposed areas for the human body. The results presented in this report emphasizes biological dosimetry as an important tool for dose assessment of either total or partial-body exposure to ionizing radiation, mainly in retrospective dose investigation. (author)

  4. Portfolio Assessment in High School Chemsitry: One Teacher's Guidelines

    Science.gov (United States)

    Phelps, Amy J.; Laporte, Mark M.; Mahood, Aileen

    1997-05-01

    It is standard practice in many chemistry classes to accept a correct numerical calculation as evidence of understanding. This happens for a variety of reasons like efficiency of grading and the presumption that evaluation done in this way is truly objective. As teachers of chemistry become more concerned with helping students develop better conceptual understandings and process skills, in addition to the development of algorithmic skills, this type of one dimensional testing is becoming increasingly less appropriate as the sole form of assessment. This paper describes the implementation of portfolio assessment in high school chemistry classrooms by one teacher in an effort to hold students accountable for more than factual recall and to involve students with an opportunity to reflect on their work throughout the year and to tell the story of their experience in high school chemistry through presentation of their best work. The portfolio was not the only assessment used in the classroom, but was a culminating experience for the students and the teacher. Early in the year the teacher established three main categories which were sub-divided into nine distinct portfolio elements. Students had to include five of the nine elements in their final portfolio project. The nine elements by category were: Category I: solve a problem, design an experiment, analyze a result, group effort in problem solving; Category II: Identify a misconception, evolution of a concept, shows growth or improvement; and Category III: defend a position and critique a current event. The portfolio elements were due at specific times throughout the second semester and there was a review process established so the students could refine their assignments. Completing the portfolio allowed students to develop a better understanding of the topics involved in the five portfolio elements through the revision process and it provided the students with the opportunity to think about what they had learned in

  5. General guidelines for the assessment of internal dose from monitoring data: Progress of the IDEAS project

    International Nuclear Information System (INIS)

    In recent major international intercomparison exercises on intake and internal dose assessments from monitoring data, the results calculated by different participants varied significantly. Based on this experience the need for harmonisation of the procedures has been formulated within an EU 5. Framework Programme research project. The aim of the project, IDEAS, is to develop general guidelines for standardising assessments of intakes and internal doses. The IDEAS project started in October 2001 and ended in June 2005. The project is closely related to some goals of the work of Committee 2 of the ICRP and since 2003 there has been close cooperation between the two groups. To ensure that the guidelines are applicable to a wide range of practical situations, the first step was to compile a database of well-documented cases of internal contamination. In parallel, an improved version of an existing software package was developed and distributed to the partners for further use. A large number of cases from the database was evaluated independently by the partners and the results reviewed. Based on these evaluations, guidelines were drafted and discussed with dosimetry professionals from around the world by means of a virtual workshop on the Internet early in 2004. The guidelines have been revised and refined on the basis of the experiences and discussions in this virtual workshop. The general philosophy of the Guidelines is presented here, focusing on the principles of harmonisation, optimisation and proportionality. Finally, the proposed Levels of Task to structure the approach of internal dose evaluation are reported. (authors)

  6. 77 FR 45329 - Availability of Microbial Risk Assessment Guideline: Pathogenic Microorganisms With Focus on Food...

    Science.gov (United States)

    2012-07-31

    ... Listserv, a free electronic mail subscription service for industry, trade groups, consumer interest groups... Food Safety and Inspection Service Availability of Microbial Risk Assessment Guideline: Pathogenic Microorganisms With Focus on Food and in Water AGENCY: Food Safety and Inspection Service, USDA. ACTION:...

  7. Best Practices for Mental Health in Child Welfare: Screening, Assessment, and Treatment Guidelines

    Science.gov (United States)

    Romanelli, Lisa Hunter; Landsverk, John; Levitt, Jessica Mass; Leslie, Laurel K.; Hurley, Maia M.; Bellonci, Christopher; Gries, Leonard T.; Pecora, Peter J.; Jensen, Peter S.

    2009-01-01

    The Best Practices for Mental Health in Child Welfare Consensus Conference focused on developing guidelines in five key areas (screening and assessment, psychosocial interventions, psychopharmacologic treatment, parent engagement, and youth empowerment) related to children's mental health. This paper provides an overview of issues related to the…

  8. Guidelines for Assessing the Need for Adaptive Devices for Visually Impaired Pedestrians at Signalized Intersections.

    Science.gov (United States)

    Gallagher, Brian R.; de Oca, Patricia Montes

    1998-01-01

    Presents guidelines for orientation and mobility instructors and traffic engineers to assess the need for adaptive devices to make crosswalks at signalized intersections accessible to pedestrians with visual impairments. The discussions of audible and tactile pedestrian devices, along with case examples, distinguish when each device should be…

  9. 76 FR 67439 - External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic...

    Science.gov (United States)

    2011-11-01

    ... AGENCY External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic... guidance for a 60 day comment period (76 FR 44586-44587). The public comment period ended on September 26... attend this peer review meeting as observers. Time will be set aside at the meeting for observers to...

  10. Clinical assessment of chest pain and guidelines for imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gruettner, J., E-mail: joachim.gruettner@umm.de [1st Department of Medicine (Cardiology), University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim (Germany); Henzler, T. [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim (Germany); Sueselbeck, T. [1st Department of Medicine (Cardiology), University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim (Germany); Fink, C. [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim (Germany); Borggrefe, M.; Walter, T. [1st Department of Medicine (Cardiology), University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim (Germany)

    2012-12-15

    For many emergency facilities, risk assessment of patients with diffuse chest pain still poses a major challenge. In their currently valid recommendations, the international cardiological societies have defined a standardized assessment of the prognostically relevant cardiac risk criteria. Here the classic sequence of basic cardiac diagnostics including case history (cardiac risk factors), physical examination (haemodynamic and respiratory vital parameters), ECG (ST segment analysis) and laboratory risk markers (troponin levels) is paramount. The focus is, on the one hand, on timely indication for percutaneous catheterization, especially in patients at high cardiac risk with or without ST-segment elevation in the ECG, and, on the other hand, on the possibility of safely discharging patients with intermediate or low cardiac risk after non-invasive exclusion of a coronary syndrome. For patients in the intermediate or low risk group, physical or pharmacological stress testing in combination with scintigraphy, echocardiography or magnetic resonance imaging is recommended in addition to basic diagnostics. Moreover, the importance of non-invasive coronary imaging, primarily cardiac CT angiography (CCTA), is increasing. Current data show that in intermediate or low risk patients this method is suitable to reliably rule out coronary heart disease. In addition, attention is paid to the major differential diagnoses of acute coronary syndrome, particularly pulmonary embolism and aortic dissection. Here the diagnostic method of choice is thoracic CT, possibly also in combination with CCTA aiming at a triple rule-out.

  11. Clinical assessment of chest pain and guidelines for imaging

    International Nuclear Information System (INIS)

    For many emergency facilities, risk assessment of patients with diffuse chest pain still poses a major challenge. In their currently valid recommendations, the international cardiological societies have defined a standardized assessment of the prognostically relevant cardiac risk criteria. Here the classic sequence of basic cardiac diagnostics including case history (cardiac risk factors), physical examination (haemodynamic and respiratory vital parameters), ECG (ST segment analysis) and laboratory risk markers (troponin levels) is paramount. The focus is, on the one hand, on timely indication for percutaneous catheterization, especially in patients at high cardiac risk with or without ST-segment elevation in the ECG, and, on the other hand, on the possibility of safely discharging patients with intermediate or low cardiac risk after non-invasive exclusion of a coronary syndrome. For patients in the intermediate or low risk group, physical or pharmacological stress testing in combination with scintigraphy, echocardiography or magnetic resonance imaging is recommended in addition to basic diagnostics. Moreover, the importance of non-invasive coronary imaging, primarily cardiac CT angiography (CCTA), is increasing. Current data show that in intermediate or low risk patients this method is suitable to reliably rule out coronary heart disease. In addition, attention is paid to the major differential diagnoses of acute coronary syndrome, particularly pulmonary embolism and aortic dissection. Here the diagnostic method of choice is thoracic CT, possibly also in combination with CCTA aiming at a triple rule-out.

  12. Portfolio assessment and evaluation: Implications and guidelines for clinical nursing education

    Directory of Open Access Journals (Sweden)

    M.M. Chabeli

    2002-09-01

    Full Text Available With the advent of Outcomes-Based Education in South Africa, the quality of nursing education is debatable, especially with regard to the assessment and evaluation of clinical nursing education, which is complex and renders the validity and reliability of the methods used questionable. This paper seeks to explore and describe the use of portfolio assessment and evaluation, its implications and guidelines for its effective use in nursing education. Firstly, the concepts of assessment, evaluation, portfolio and alternative methods of evaluation are defined. Secondly, a comparison of the characteristics of the old (traditional methods and the new alternative methods of evaluation is made. Thirdly, through deductive analysis, synthesis and inference, implications and guidelines for the effective use of portfolio assessment and evaluation are described.

  13. Optimal Pain Assessment in Pediatric Rehabilitation: Implementation of a Nursing Guideline.

    Science.gov (United States)

    Kingsnorth, Shauna; Joachimides, Nick; Krog, Kim; Davies, Barbara; Higuchi, Kathryn Smith

    2015-12-01

    In Ontario, Canada, the Registered Nurses' Association promotes a Best Practice Spotlight Organization initiative to enhance evidence-based practice. Qualifying organizations are required to implement strategies, evaluate outcomes, and sustain practices aligned with nursing clinical practice guidelines. This study reports on the development and evaluation of a multifaceted implementation strategy to support adoption of a nursing clinical practice guideline on the assessment and management of acute pain in a pediatric rehabilitation and complex continuing care hospital. Multiple approaches were employed to influence behavior, attitudes, and awareness around optimal pain practice (e.g., instructional resources, electronic reminders, audits, and feedback). Four measures were introduced to assess pain in communicating and noncommunicating children as part of a campaign to treat pain as the fifth vital sign. A prospective repeated measures design examined survey and audit data to assess practice aligned with the guideline. The Knowledge and Attitudes Survey (KNAS) was adapted to ensure relevance to the local practice setting and was assessed before and after nurses' participation in three education modules. Audit data included client demographics and pain scores assessed annually over a 3-year window. A final sample of 69 nurses (78% response rate) provided pre-/post-survey data. A total of 108 pediatric surgical clients (younger than 19 years) contributed audit data across the three collection cycles. Significant improvements in nurses' knowledge, attitudes, and behaviors related to optimal pain care for children with disabilities were noted following adoption of the pain clinical practice guideline. Targeted guideline implementation strategies are central to supporting optimal pain practice. PMID:26395294

  14. Toxicity guidelines for waste assessment of nuclear power scenarios

    International Nuclear Information System (INIS)

    Under the provisions of the 1991 French radioactive waste management law, various fuel cycle scenarios will be assessed and compared in terms of feasibility, flexibility, cost, and ultimate waste radio-toxic inventory. The latter criterion may be further broken down into 'potential radio-toxic inventory' (the radio-toxic inventory of all the radionuclides produced) and 'residual radio-toxic inventory' (the radionuclide fraction reaching the biosphere alter migration from the repository). The innovative scientific contribution of this study is to consider a third type of radio-toxic inventory: the potential radio-toxic inventory alter conditioning, i.e. taking into account the containment capacity of the radionuclide conditioning matrices. The matrix fraction subjected to alteration over time determines the potential for radionuclide release, hence the notion of the potential radio-toxic inventory alter conditioning. An initial comparison of possible scenarios is proposed by considering orders of magnitude for the radionuclide containment capacity of the disposal matrices and for their mobilization potential. All the scenarios investigated are normalized to the same annual electric power production so that a legitimate comparison can be established for the ultimate wasteform produced per year of operation. This approach reveals significant differences among the scenarios considered that do not appear when only the raw potential radio-toxic inventory is taken into account. The matrix containment performance has a decisive effect on the final impact of a given scenario or type of scenario. Pu recycling scenarios thus reduce the potential radio-toxicity by roughly a factor of 50 compared with an open cycle; the gain rises to a factor of about 300 for scenarios in which Pu and the minor actinides are recycled. Interestingly, the results obtained by the use of a dedicated containment matrix for the minor actinides in a scenario limited to Pu recycling were comparable to

  15. Bothrops lanceolatus bites: guidelines for severity assessment and emergent management.

    Science.gov (United States)

    Resiere, Dabor; Mégarbane, Bruno; Valentino, Ruddy; Mehdaoui, Hossein; Thomas, Laurent

    2010-01-01

    Approximately 20-30 declared snakebite cases occurin Martinique each year. Bothrops lanceolatus, a member of the Crotalidae family, is considered to be the only involved snake. B. lanceolatus, commonly named "Fer-de-Lance", is endemic and only found on this Caribbean island. Envenomation local features include the presence of fang marks, swelling, pain, bleeding from punctures, and ecchymosis. Severe envenomation is associated with multiple systemic thromboses appearing within 48 h of the bite and resulting in cerebral, myocardial or pulmonary infarctions. Diagnosis requires first of all identification of the snake. Coagulation tests are helpful to identify thrombocytopenia or disseminated intravascular coagulation. A clinical score based on 4 grades is helpful to assess envonimation severity. A specific monovalent equine anti-venom (Bothrofav(®), Sanofi-Pasteur, France) to neutralize B. lanceolatus venom is available. Its early administration within 6h from the biting in case of progressive local injures, general signs or coagulation disturbances is effective to prevent severe thrombosis and coagulopathy. Its tolerance is considered to be good. Despite an increasing incidence of bites, no deaths have been recently attributed to B. lanceolatus in Martinique, probably due to the currently recommended strategy of early antivenom administration when required. PMID:22069552

  16. Assessment of EPRI water chemistry guidelines for new nuclear power plants

    International Nuclear Information System (INIS)

    Water chemistry control technologies for nuclear power plants have been significantly enhanced over the past few decades to improve material and equipment reliability and fuel performance, and to minimize radionuclide production and transport. Chemistry Guidelines have been developed by the Electric Power Research Institute (EPRI) for current operating plants and have been intermittently revised over the past twenty-five years for the protection of systems and components and for radiation management. As new plants are being designed for improved safety and increased power production, it is important to ensure that the designs consider implementation of industry approved water chemistry controls. In parallel, the industry will need to consider and develop updated water chemistry guidelines as well as plant startup and operational strategies based on the advanced plant designs. In 2010, EPRI began to assess chemistry control strategies at advanced plants, based on the Design Control Documents (DCDs), Combined Construction and Operating License Applications (COLA), and operating experiences (where they exist) against current Water Chemistry Guidelines. Based on this assessment, differences between planned chemistry operations at new plants and the current Guidelines will be identified. This assessment will form the basis of future activities to address these differences. The project will also assess and provide, as feasible, water chemistry guidance for startup and hot functional testing of the new plants. EPRI will initially assess the GE-Hitachi/Toshiba ABWR and the Westinghouse AP1000 designs. EPRI subsequently plans to assess other plant designs such as the AREVA U.S. EPR, Mitsubishi Heavy Industries (MHI) U.S. APWR, and GE-Hitachi (GE-H) ESBWR. This paper discusses the 2010 assessments of the ABWR and AP1000. (author)

  17. Guideline for assessing the performance of electric power systems in natural hazard and human threat events

    Science.gov (United States)

    Savage, W.U.; Nishenko, S.P.; Honegger, D.G.; Kempner, L., Jr.

    2006-01-01

    Electric power utilities are familiar with and skilled in preparing for and responding to almost-routine natural hazard events such as strong wind and ice storms and seasonal floods, as well as intentional human acts such as vandalism. Recent extreme weather (hurricanes Katrina and Rita), extremely destructive international earthquakes (in Sumatra and Pakistan), and nation-wide concerns regarding future terrorist attacks have increased the pressure on utilities to take appropriate steps to avoid being overwhelmed by such infrequent and exceedingly severe events. Determining what constitutes the appropriate steps to take requires various levels of understanding of the specific hazards and the risks faced by the utility. The American Lifelines Alliance (www. americanlifelinesalliance.org) has prepared a Guideline that provides clear, concise, and nationally-applicable guidance on determining the scope and level of effort necessary to assess power system performance in the wide range of natural hazard or human threat events. Included in this Guideline are specific procedures to follow and information to consider in performing standardized assessments. With the results of such assessments, utility owners can effectively establish and carry out risk management programs that will lead to achieving appropriate levels of performance in future events. The Guideline incorporates an inquiry-driven process with a two-phase performance assessment that can be applied to power systems of any size. The screening phase enables systems or components that are clearly not at risk to be screened out early. The subsequent analysis phase uses results from the screening phase to prioritize and allocate resources for more detailed assessments of hazard, vulnerability, and system performance. This process helps assure that the scope of the assessment meets the specific performance objectives of the inquiry. A case history is presented to illustrate the type of experience with an inquiry

  18. Assessment of external costs for transport project evaluation: Guidelines in some European countries

    Energy Technology Data Exchange (ETDEWEB)

    Petruccelli, Umberto, E-mail: umberto.petruccelli@unibas.it

    2015-09-15

    Many studies about the external costs generated by the transport system have been developed in the last twenty years. To standardize methodologies and assessment procedures to be used in the evaluation of the projects, some European countries recently have adopted specific guidelines that differ from each other in some aspects even sensibly. This paper presents a critical analysis of the British, Italian and German guidelines and is aimed at cataloguing the external cost types regarded and the assessment methods indicated as well as to highlight the differences of the results, in terms of applicability and reliability. The goal is to contribute to a European standardization process that would lead to the drafting of guidelines suited for all EU countries. - Highlights: • The analyzed guidelines agree on the methods to evaluate costs from air pollution, greenhouse gases and accidents. • They recommend respectively: dose-resp. approach; costs to reduce/permit emissions; whole direct, indirect and social costs. • For noise, DE guide indicates defensive expenditure or SP methods; IT guide, SP method; UK guide, the hedonic prices one. • For on territory impact, DE guide regards only the barrier effect; the IT one, also the soil consumption and system effects. • British guide proposes a qualitative methodology to estimate the impact on various landscapes and environments.

  19. Assessment of external costs for transport project evaluation: Guidelines in some European countries

    International Nuclear Information System (INIS)

    Many studies about the external costs generated by the transport system have been developed in the last twenty years. To standardize methodologies and assessment procedures to be used in the evaluation of the projects, some European countries recently have adopted specific guidelines that differ from each other in some aspects even sensibly. This paper presents a critical analysis of the British, Italian and German guidelines and is aimed at cataloguing the external cost types regarded and the assessment methods indicated as well as to highlight the differences of the results, in terms of applicability and reliability. The goal is to contribute to a European standardization process that would lead to the drafting of guidelines suited for all EU countries. - Highlights: • The analyzed guidelines agree on the methods to evaluate costs from air pollution, greenhouse gases and accidents. • They recommend respectively: dose-resp. approach; costs to reduce/permit emissions; whole direct, indirect and social costs. • For noise, DE guide indicates defensive expenditure or SP methods; IT guide, SP method; UK guide, the hedonic prices one. • For on territory impact, DE guide regards only the barrier effect; the IT one, also the soil consumption and system effects. • British guide proposes a qualitative methodology to estimate the impact on various landscapes and environments

  20. Guidelines for the Assessment of Dredge Material for Disposal in Irish Waters

    OpenAIRE

    Cronin, M.; McGovern, E.; McMahon, T.; Boelens, R

    2006-01-01

    Prior to the present guidelines the assessment, by the Marine Institute on behalf of the Department of Communication, Marine and Natural Resources, of the suitability of dredged materials for disposal at sea had employed provisional action levels as an aid to evaluation. These provisional action levels were based entirely on sediment chemistry. The responsible agencies have decided that these levels now need to be updated and formalised. The approach proposed in this document aims to provi...

  1. Adoption of practice guidelines and assessment tools in substance abuse treatment

    OpenAIRE

    McCarty Dennis; Saedi Goal; Fuller Bret E; Rieckmann Traci

    2010-01-01

    Abstract Background The gap between research and practice limits utilization of relevant, progressive and empirically validated strategies in substance abuse treatment. Methods Participants included substance abuse treatment programs from the Northeastern United States. Structural equation models were constructed with agency level data to explore two outcome variables: adoption of practice guidelines and assessment tools at two points in time; models also included organizational, staffing and...

  2. Venous thromboembolism (VTE) risk assessment and prophylaxis in acute orthopaedic admissions: improving compliance with national guidelines

    OpenAIRE

    Watts, Laura; Grant, David

    2013-01-01

    “Each year over 25,000 people die from Venous Thromboembolism (VTE) contracted in hospital. This is more than the combined total of deaths from breast cancer, AIDS and traffic accidents”. (1) Orthopaedic patients are at particular risk of VTE. In 2011, the project team carried out an audit into compliance with national VTE assessment guidelines on all acute trauma and orthopaedic admissions during a two week period at a District General Hospital. The study demonstrated that compliance was ini...

  3. Development and Assessment of a Multiplex Real-Time PCR Assay for Quantification of Human Immunodeficiency Virus Type 1 DNA▿

    OpenAIRE

    Beloukas, A.; Paraskevis, D.; Haida, C.; Sypsa, V.; Hatzakis, A

    2009-01-01

    Previous studies showed that high levels of human immunodeficiency virus type 1 (HIV-1) DNA are associated with a faster progression to AIDS, an increased risk of death, and a higher risk of HIV RNA rebound in patients on highly active antiretroviral therapy. Our objective was to develop and assess a highly sensitive real-time multiplex PCR assay for the quantification of HIV-1 DNA (RTMP-HIV) based on molecular beacons. HIV-1 DNA quantification was carried out by RTMP in a LightCycler 2.0 app...

  4. Operational safety review programmes for nuclear power plants. Guidelines for assessment

    International Nuclear Information System (INIS)

    The IAEA has been offering the Operational Safety Review Team (OSART) programme to provide advice and assistance to Member States in enhancing the operational safety of nuclear power plants (NPPs). Simultaneously, the IAEA has encouraged self-assessment and review by Member States of their own nuclear power plants to continuously improve nuclear safety. Currently, some utilities have been implementing safety review programmes to independently review their own plants. Corporate or national operational safety review programmes may be compliance or performance based. Successful utilities have found that both techniques are necessary to provide assurance that (i) as a minimum the NPP meets specific corporate and legal requirements and (ii) management at the NPP is encouraged to pursue continuous improvement principles. These programmes can bring nuclear safety benefits to the plants and utilities. The IAEA has conducted two pilot missions to assess the effectiveness of the operational review programme. Based on these missions and on the experience gained during OSART missions, this document has been developed to provide guidance on and broaden national/corporate safety review programmes in Member States, and to assist in maximizing their benefits. These guidelines are intended primarily for the IAEA team to conduct assessment of a national/corporate safety review programme. However, this report may also be used by a country or utility to establish its own national/corporate safety review programme. The guidelines may likewise be used for self-assessment or for establishing a baseline when benchmarking other safety review programmes. This report consists of four parts. Section 2 addresses the planning and preparation of an IAEA assessment mission and Sections 3 and 4 deal with specific guidelines for conducting the assessment mission itself

  5. General guidelines for the assessment of internal dose from monitoring data (project Ideas)

    International Nuclear Information System (INIS)

    In recent major international intercomparison exercises on intake and internal dose assessments from monitoring data, the results calculated by different participants varied significantly. This was mainly due to the broad variety of methods and assumptions applied in the assessment procedure. Based on these experiences the need for harmonization of the procedures has been formulated within an EC research project under the 5. Framework Programme. The aim of the project, IDEAS, is to develop general guidelines for standardizing assessments of intakes and internal doses. The IDEAS project started in October 2001 and will end in March 2005. Eight institutions from seven European countries are participating. Inputs from internal dosimetry professionals from across Europe are also being used to ensure a broad consensus in the outcome of the project. The IDEAS project is closely related to some goals of the work of committee 2 of the ICRP and since 2003 there has been close cooperation between the two groups. To ensure that the guidelines are applicable to a wide range of practical situations, the first step has been to compile a database of well-documented cases of internal contamination. In parallel, an improved version of an existing software package has been developed and distributed to the partners for further use. A large number of cases from the database have been evaluated independently by partners in the project using the same software and the results have been reviewed. Based on these evaluations, guidelines are being drafted and will be discussed with dosimetry professionals from around the world by means of a virtual workshop on the Internet early in 2004. The guidelines will be revised and refined on the basis of the experiences and discussions of this virtual workshop and the outcome of an intercomparison exercise organised as part of the project. This will be open to all internal dosimetry professionals. (author)

  6. Guideline for assessing risks arising from adoption of a cloud service

    OpenAIRE

    Tomčová, Zuzana

    2014-01-01

    This thesis focuses on assessment of IT risks related to company's adoption of a cloud ser-vice. The goal of the thesis is to identify generally applicable set of IT risks, which will serve as a basis for the proposed risk assessment guideline. The work is organized as follows: Introduction and literature review is presented in the first chapter. The author provides theoretical background supporting better understand-ing of the topic in the Chapter two, where concept of the cloud computing an...

  7. APPLICATION OF SEDIMENT QUALITY GUIDELINES IN THE ASSESSMENT OF MANGROVE SURFACE SEDIMENT IN MENGKABONG LAGOON, SABAH, MALAYSIA

    Directory of Open Access Journals (Sweden)

    S. M. Praveena, M. Radojevic, M. H. Abdullah, A. Z. Aris

    2008-01-01

    Full Text Available There have been numerous sediment quality guidelines developed to monitor the sediments. Sediment quality guidelines are very useful to screen sediment contamination by comparing sediment contaminant concentration with the corresponding quality guideline, provide useful tools for screening sediment chemical data to identify pollutants of concern and prioritise problem sites and relatively good predictors of contaminations. However, these guidelines are chemical specific and do not include biological parameters. Aquatic ecosystems, including sediments, must be assessed in multiple components (biological data, toxicity, physicochemistry by using intregrated approaches in order to establish a complete and comprehensive set of sediment quality guidelines. Numerous sediment quality guidelines Washington Department of Ecology Sediment Quality Guideline, Australian and New Zealand Environment and Conservation Council, Swedish Environmental Sediment Quality, Screening Quick Reference Table, Portuguese Legislation on the Classification of Dredged Materials in Coastal Zones and Interim Sediment Quality Guideline for Hong Kong have been applied to the Mengkabong lagoon mangrove sediment and discussed. The most appropriate guideline that meets the prioritization criteria consistent with international initiatives and regulations is interim sediment quality values for Hong Kong. The guideline verifies that all the metals are below the Interim Sediment Quality Value-low. However, site-specific, biological testing and ecological analysis of exisiting benthics community structure related to sediment contamination are needed for final decision making in the case of Mengkabong lagoon.

  8. Preliminary Guideline for the High Temperature Structure Integrity Assessment Procedure Part I. High Temperature Structure Design Guide

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Han; Kim, J. B.; Lee, H. Y.; Park, C. G.; Joo, Y. S.; Koo, G. H.; Kim, S. H

    2007-02-15

    A preliminary guideline for the design and evaluation of LMR high temperature structure is presented based upon ASME B and PV Code, Section III, Subsection NH. The main contents of this guideline are the materials, general design, vessel, piping, core support structure, pumps, valves, fabrication, examination, and testing for the class 1 components. The ratcheting evaluation, enhanced creep assessment, welds design and evaluation, inelastic analysis approach, piping design alternatives, and bellows design method are described in appendices. A user of this guideline should follow the essential procedures and may refer to other pertinent codes, standards, laws, regulations, or other pertinent documents when this guideline does not lead to proper design of the structure. While this guideline adopts major procedures of Subsection NH, it refers to the RCC-MR and/or DDS in some amount for the items where these codes have excellency to improve this guideline.

  9. Modeling and Quantification of Team Performance in Human Reliability Analysis for Probabilistic Risk Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey C. JOe; Ronald L. Boring

    2014-06-01

    Probabilistic Risk Assessment (PRA) and Human Reliability Assessment (HRA) are important technical contributors to the United States (U.S.) Nuclear Regulatory Commission’s (NRC) risk-informed and performance based approach to regulating U.S. commercial nuclear activities. Furthermore, all currently operating commercial NPPs in the U.S. are required by federal regulation to be staffed with crews of operators. Yet, aspects of team performance are underspecified in most HRA methods that are widely used in the nuclear industry. There are a variety of "emergent" team cognition and teamwork errors (e.g., communication errors) that are 1) distinct from individual human errors, and 2) important to understand from a PRA perspective. The lack of robust models or quantification of team performance is an issue that affects the accuracy and validity of HRA methods and models, leading to significant uncertainty in estimating HEPs. This paper describes research that has the objective to model and quantify team dynamics and teamwork within NPP control room crews for risk informed applications, thereby improving the technical basis of HRA, which improves the risk-informed approach the NRC uses to regulate the U.S. commercial nuclear industry.

  10. ARN Training on Advance Methods for Internal Dose Assessment: Application of Ideas Guidelines

    International Nuclear Information System (INIS)

    Dose assessment in case of internal exposure involves the estimation of committed effective dose based on the interpretation of bioassay measurement, and the assumptions of hypotheses on the characteristics of the radioactive material and the time pattern and the pathway of intake. The IDEAS Guidelines provide a method to harmonize dose evaluations using criteria and flow chart procedures to be followed step by step. The EURADOS Working Group 7 'Internal Dosimetry', in collaboration with IAEA and Czech Technical University (CTU) in Prague, promoted the 'EURADOS/IAEA Regional Training Course on Advanced Methods for Internal Dose Assessment: Application of IDEAS Guidelines' to broaden and encourage the use of IDEAS Guidelines, which took place in Prague (Czech Republic) from 2-6 February 2009. The ARN identified the relevance of this training and asked for a place for participating on this activity. After that, the first training course in Argentina took place from 24-28 August for training local internal dosimetry experts. This paper resumes the main characteristics of this activity. (authors)

  11. High Temperature Structure Leak Before Break Assessment Guideline(V1.0)

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chang-Gyu; Kim, Jong-Bum; Lee, Hyeong-Yeon; Joo, Young-Sang; Lee, Jae-Han

    2007-03-15

    This study describes the Leak Before Break(LBB) procedure applicable to the reactor structure of Liquid Metal Reactor(LMR) which is operated at a high temperature. The purpose of LBB in LMR is to assure the defence in depth safety. The technically advanced countries of LMR development, such as Japan, UK and France, have their own LBB evaluation code. Their procedures are investigated thoroughly and the draft edition of LBB assessment guideline for the high temperature LMR structures is proposed. The key issues are the defect initiation, the defect propagation and the fast rupture of structures under the fatigue loading or the creep-fatigue loading condition. Additionlly, the detectable defect length and crack opening evaluation for the leakage detection method are analyzed and included in this guideline. Additionally, the detectable defect length and the creep-fatigue defect growth with a circumferential through wall defect for a KALIMER-600 IHTS hot leg piping based on this high temperature LBB assessment guideline were evaluated.

  12. Assessment of EPRI water chemistry guidelines for new nuclear power plants

    International Nuclear Information System (INIS)

    Water chemistry control technologies for nuclear power plants have been significantly enhanced over the past few decades to improve material and equipment reliability and fuel performance, and to minimize radionuclide production and transport. Chemistry Guidelines have been developed by the Electric Power Research Institute (EPRI) for currently operating plants and have been intermittently revised over the past twenty-five years for the protection of systems and components and for radiation management. As new plants are being designed for improved safety and increased power production, it is important to ensure that the designs consider implementation of state-of-the-art, industry developed water chemistry controls. In parallel, the industry will need to consider and update water chemistry guidelines as well as plant startup and operational strategies based on the advanced plant designs. EPRI has performed assessments of water chemistry control guidance or assumptions provided in design and licensing documents for several advanced plant designs. These designs include: Westinghouse AP1000 Pressurized Water Reactor AREVA US-EPR Pressurized Water Reactor Mitsubishi Nuclear Energy Systems/Mitsubishi Heavy Industries Advanced Pressurized Water Reactor Korea Hydro and Nuclear Power APR1400 Pressurized Water Reactor Toshiba Advanced Boiling Water Reactor (ABWR) General Electric-Hitachi Economic Simplified Boiling Water Reactor (ESBWR) The intent of these assessments was to identify key design differences in each of the new plant designs relative to the current operating fleet and to identify differences in water chemistry specifications or design assumptions provided in design and licensing documents for the plants in comparison to current EPRI Water Chemistry Guidelines. This paper provides a summary of the key results of these assessments. The fundamental design and operation of the advanced plants is similar to the currently operating fleet. As such, the new plants are

  13. Application of IDEAS guidelines: the IDEAS/IAEA intercomparison exercise on internal dose assessment

    International Nuclear Information System (INIS)

    As part of the EU Fifth Framework Programme IDEAS project 'General Guidelines for the Evaluation of Incorporation Monitoring Data', and in collaboration with the International Atomic Energy Agency, a new intercomparison exercise for the assessment of doses from intakes of radionuclides was organised. Several cases were selected, to cover a wide range of practices in the nuclear fuel cycle and medical applications. The cases were: (1) acute intake of HTO, (2) acute inhalation of the fission products 137Cs and 90Sr, (3) acute inhalation of 60Co, (4) repeated intakes of 131I, (5) intake of enriched uranium and (6) single intake of Pu isotopes and 241Am. This intercomparison exercise especially focused on the effect of the Guidelines proposed by the IDEAS project for harmonization of internal dosimetry. (authors)

  14. Trend of glycated hemoglobin testing in diabetic patients: to assess compliance with clinical practice guidelines

    International Nuclear Information System (INIS)

    Objective: To determine appropriate use of glycated hemoglobin (HbA1c) testing in accordance with current recommended guidelines. Study Design: Descriptive study. Place and Duration of Study: Chemical Pathology Department Shifa International Hospital, Islamabad from Oct 2011 to Oct 2012. Material and Methods: We randomly selected 170 known diabetic patients' data from our Laboratory Information System (LIS) who were retrospective analyzed for HbA1c to check for intervals and test frequency for each patient in one year. Patients with follow-up for at least one year at Shifa International Hospital, Islamabad and having their routine investigations in our chemical pathology laboratory were included. The concentrations of HbA1c for all the specimens were measured immunoturbidimetrically using a microparticle agglutination inhibition method. Four guidelines namely World Health Organization (WHO), American Diabetic Association (ADA), Canadian Diabetic Association (CDA) and National Institute for Health and Clinical Excellence (NICE) about HbA1c testing were utilized for data interpretation. All tests ordered within a 2 months period or more than 6 months following the previous order were labeled as inappropriate. Results: Only 35.8% of the patients were being properly monitored as per guidelines. Out of 64% patients who were inappropriately monitored, 12.9% had repeat orders within 2 months while 51.1% of patients were being monitored at longer interval against recommended guidelines. Conclusions: Glycated hemoglobin is a useful tool to objectively assess the prior glycemic control of patients with type 1 and type 2 diabetes. The study highlights that in large proportion of diabetic patients, HbA1c is not utilized properly as a tool to assess the risk of diabetic complications but in a small proportion is also tested unnecessarily which adds to avoidable health expenditure. (author)

  15. A framework for evidence-adaptive quality assessment that unifies guideline-based and performance-indicator approaches.

    OpenAIRE

    Advani, Aneel; Goldstein, Mary; Musen, Mark A.

    2002-01-01

    Automated quality assessment of clinician actions and patient outcomes is a central problem in guideline- or standards-based medical care. In this paper we describe a unified model representation and algorithm for evidence-adaptive quality assessment scoring that can: (1) use both complex case-specific guidelines and single-step population-wide performance-indicators as quality measures; (2) score adherence consistently with quantitative population-based medical utilities of the quality measu...

  16. Assessment of morphological changes and DNA quantification: An in vitro study on acid-immersed teeth

    Directory of Open Access Journals (Sweden)

    K Sowmya

    2013-01-01

    Full Text Available Context: Acid immersion of victim′s body is one of the methods employed to subvert identification of the victim, and hence of the perpetrator. Being hardest and chemically the most stable tissue in the body, teeth can be an important forensic investigative medium in both living and nonliving populations. Teeth are also good reservoirs of both cellular and mitochondrial DNA; however, the quality and quantity of DNA obtained varies according to the environment the tooth has been subjected to. DNA extraction from acid-treated teeth has seldom been reported. Aims: The objectives of the present study were to assess the morphological changes along with DNA recovery from acid-immersed teeth. Materials and Methods: Concentrated hydrochloric acid, nitric acid, and sulfuric acid were employed for tooth decalcification. DNA was extracted on an hourly basis using phenol-chloroform method. Quantification of extracted DNA was done using a spectrophotometer. Results: Results showed that hydrochloric acid had more destructive capacity compared to other acids. Conclusion: Sufficient quantity of DNA was obtainable till the first 2 hours of acid immersion and there was an inverse proportional relation between mean absorbance ratio and quantity of obtained DNA on an hourly basis.

  17. Assessment and quantification of plastics waste generation in major 60 cities of India.

    Science.gov (United States)

    Nalini, R; Srinivasulu, B; Shit, Subhas C; Nigam, Suneel Kumar; Akolkar, A B; Dwivedfi, R K

    2013-04-01

    Polymers or plastics materials registered rapid growth in 1970s, 1980s and 1990s at the rate of 2-2.5 times the GDP growth in India. The demand for plastic raw material got more than doubled from 3.3 Million Metric Ton to 6.8 Million Metric Tons in 2010 attributed mainly to rapid urbanization, spread of retail chains, plastics based packaging from grocery to food and vegetable products to cosmetics and consumer items. Plastics packages have its merits over many of conventional materials in the related sector but unless they are collected back effectively after their use to go into recycling process, they become an eyesore in the stream of Municipal Solid Waste (MSW) due to high visibility. As the synthetic and conventional plastics are non-biodegradable in nature, these remain in the dump yards/ landfills for several years, if not collected properly. Due to non- biodegradability, plastics waste remains in the environment for several years, if not collected and disposing plastics wastes at landfills are unsafe since toxic chemicals leach out into the soil and as they contaminate soil and underground water quality. The municipal solid waste also increasing day-by-day due to the inefficient source collection, segregation and transmission of plastics waste for recycling and reusing. In order to find out the realistic plastics waste generation, a study on assessment and quantification of plastics waste has been carried out by CPCB in collaboration with CIPET on selected 60 major cities of India. PMID:25508322

  18. Reliability and accuracy assessment of radiation therapy oncology group-endorsed guidelines for brachial plexus contouring

    International Nuclear Information System (INIS)

    The goal of this work was to validate the Radiation Therapy Oncology Group (RTOG)-endorsed guidelines for brachial plexus (BP) contouring by determining the intra- and interobserver agreement. Accuracy of the delineation process was determined using anatomically validated imaging datasets as a gold standard. Five observers delineated the right BP on three cadaver computed tomography (CT) datasets. To assess intraobserver variation, every observer repeated each delineation three times with a time interval of 2 weeks. The BP contours were divided into four regions for detailed analysis. Inter- and intraobserver variation was verified using the Computerized Environment for Radiation Research (CERR) software. Accuracy was measured using anatomically validated fused CT-magnetic resonance imaging (MRI) datasets by measuring the BP inclusion of the delineations. The overall kappa (κ) values were rather low (mean interobserver overall κ: 0.29, mean intraobserver overall κ: 0.45), indicating poor inter- and intraobserver reliability. In general, the κ coefficient decreased gradually from the medial to lateral BP regions. The total agreement volume (TAV) was much smaller than the union volume (UV) for all delineations, resulting in a low Jaccard index (JI; interobserver agreement 0-0.124; intraobserver agreement 0.004-0.636). The overall accuracy was poor, with an average total BP inclusion of 38 %. Inclusions were insufficient for the most lateral regions (region 3: 21.5 %; region 4: 12.6 %). The inter- and intraobserver reliability of the RTOG-endorsed BP contouring guidelines was poor. BP inclusion worsened from the medial to lateral regions. Accuracy assessment of the contours showed an average BP inclusion of 38 %. For the first time, this was assessed using the original anatomically validated BP volume. The RTOG-endorsed BP guidelines have insufficient accuracy and reliability, especially for the lateral head-and-neck regions. (orig.)

  19. Adherence to guidelines of pain assessment and intervention in internal medicine wards.

    Science.gov (United States)

    Kerner, Yehudit; Plakht, Ygal; Shiyovich, Arthur; Schlaeffer, Pnina

    2013-12-01

    Proper management of pain reduces morbidity, assists in recovery, and increases patient satisfaction. The role of a nurse in an accurate pain evaluation is pivotal. It seems that pain evaluation guidelines are not fully adhered to by nurses. The aim of this study was to assess the performance of pain evaluation and management by nurses in patients admitted in internal medicine wards and to identify groups of patients in which pain evaluation was insufficient. In this cross-sectional study medical records of 59 randomly chosen patients were reviewed: age 64.5 ± 18.5 years, 55% women, and hopitalization length 3.9 ± 1.6 days. Data relating to pain evaluation and management were obtained for every patient-hospitalization day (total 213 patient-days) and compared with the guidelines. Pain was evaluated in 176 out of 213 encounters (66.2%): 84.3% upon admission and 72.7% daily routine evaluation in accordance with guidelines. In 23.7% of evaluations, pain level warranted alleviating treatment (visual analog scale ≥3). However, such treatment was administered in only 29.3% of these cases. Reevaluation after treatment and additional evaluations thereafter were performed in 33.3% and 22% of encounters, respectively. The independent factors associated with the reduced performance of pain evaluation were: widower (odds ratio [OR] 0.88, 95% confidence interval [CI] 0.78-0.98; p = .024), reduced level of consicousnness (OR 0.77, 95% CI 0.63-0.95; p = .013), mental disorders as a cause of hospitalization (OR 0.81, 95% CI 0.71-0.94; p = .004), and isolation (OR 0.87, 95% CI 0.76-0.99; p = .03). Pain assessment and management in internal medicine wards is insufficient, especially in the above subgroups. Specific education programs targeted to the latter subgroups and to the unique pain assessment tools are warranted. PMID:23178103

  20. 246 Assessment of the Quality of Methodological Rigour and Reporting of Clinical Practice Guidelines for the Management of Allergic Rhinitis—Qugar Study

    OpenAIRE

    Padjas, Agnieszka; Schünemann, Holger,; Bousquet, Jean; Brozek, Jan

    2012-01-01

    Background To assess the methodological rigour and transparency of reporting in clinical practice guidelines for the management of allergic rhinitis (AR). Methods We systematically searched MEDLINE, TRIP database (including the National Guidelines Clearinghouse) and professional society websites for guidelines about the management of AR published after the year 2000. We assumed that older guidelines would no longer influence current clinical practice. If the guideline was updated after 2000 w...

  1. European project for developing general guidelines for harmonising internal dose assessment procedures (IDEAS)

    International Nuclear Information System (INIS)

    Several international intercomparison exercises on intake and internal dose assessments from monitoring data led to the conclusion that the results calculated by different participants varied significantly mainly because of the wide variety of methods and assumptions applied in the assessment procedure. Based on these experiences the need for harmonisation of the procedures has been formulated as an EU research project under the 5th Framework Programme (2001-2005), with the aim of developing general guidelines for standardising assessments of intakes and internal doses. In the IDEAS project eight institutions from seven European countries are participating using inputs also from internal dosimetry professionals from across Europe to ensure broad consensus in the outcome of the project. The IDEAS project is explained

  2. AMAT guidelines. Reference document for the IAEA Ageing Management Assessment Teams (AMATs)

    International Nuclear Information System (INIS)

    Effective ageing management is an important element for ensuring the safety of nuclear power plant. The IAEA Ageing Management Assessment Team (AMAT) programme provides advice and assistance to utilities or individual NPPs to strengthen and enhance the effectiveness of ageing management programs (AMPs). Such AMPs are required by an increasing number of safety utilities and implemented by an increasing number of utilities, often as a part of NPP life or life cycle management programs that involve the integration of ageing management and economic planning. The guidelines in this report are primarily intended for IAEA-led AMAT team members as a basic structure and common reference for peer reviews of AMPs

  3. Summary report on new regulatory codes and criteria and guidelines: IAEA guidelines for WWER reactor coolant system integrity assessment

    International Nuclear Information System (INIS)

    In the frame of the nuclear safety programme to assist the countries of Central and Eastern Europe, the IAEA identified and ranked in total 263 safety issues for WWER-440/230, WWER-440/213 and WWER-1000/320 nuclear power plants, related to both design and operation. In the area of reactor coolant system integrity, 24 safety issues were identified and 15 of them ranked as of high safety significance. These include: reactor pressure-vessel integrity and related aspects, primary and secondary high-energy piping integrity, steam generator integrity and reliability of the non-destructive testing for in-service inspection. In addition to obtaining international consensus on possible solutions to address the safety issues identified and to reviewing completeness of proposed safety improvements, the IAEA initiated development of guidelines to address the issues of highest safety concern. In the area of the reactor coolant system integrity, guidelines for the leak before break concept application, for the pressurized thermal shock analysis and for the in-service inspection systems qualification were developed. Further activities of the IAEA were focused on the implementation of guidelines developed in the Member States concerned. With this objective, a co-ordinated research programme 'round-robin exercise on WWER-440 reactor pressure vessel embrittlement, annealing and re-embrittlement', a 'WWER-440/213 pressurized thermal shock analysis benchmark exercise' and a pilot study to implement the qualification approach to a real power plant component have been initiated by the IAEA and are well under way at present. In this paper, an overview of these IAEA activities related to reactor coolant system integrity is provided and the main principles and elements of guidelines developed discussed. (orig.)

  4. The application of national and international guidelines in the assessment of the radiological quality of drinking water

    International Nuclear Information System (INIS)

    Full text: The World Health Organisation has developed international guidelines for drinking water quality which define acceptable levels of contaminants including radionuclides. These guidelines were the basis for the recent Australian water quality guidelines developed by the National Health and Medical Research Council in conjunction with the Agriculture and Resource Management Council of Australia and New Zealand. This paper highlights some of the practical problems in applying the guidelines in the assessment of groundwater supplies in Australia where the radium content of the water may be significant and the presence of other dissolved minerals can create difficulties in the analytical procedures. Generally, screening methods are based on the determination of gross alpha and beta radioactivity and the limitations of these techniques are discussed. The issue is also addressed as to the appropriate actions in the event of guideline values for specific radionuclides being exceeded

  5. Risk quantification in deterministic procedures: outage key safety functions evaluation using probabilistic risk assessment

    International Nuclear Information System (INIS)

    In 2007 a collaboration agreement between the Nuclear Industry and the Nuclear Engineering Research Group of the Technical University of Catalonia (NERG-UPC) began on the Risk-Informed Operation Decision Management field. A Manual has been created; it provides a guidance of the systematic of using Probabilistic Risk Assessment for the evaluation of guides or procedures which ensure the compliment of Outage Key Safety Functions (OKSF) in nuclear power plants. The evaluation base is probabilistic; the core damage frequencies (CDF) values determine the acceptance of the analyzed guides and encourage suggestions for improvements in the contained procedures. Acceptance criteria from Plants Supervision System are used throw out quantifications. The developed methodology pretends to evaluate the risk associated to the availability system configurations during the outage. The documents used in the development have been: PRA, OKSF procedure and Performance Technical Specifications (PTS) from a 3 loops Westinghouse PWR. As a pilot experience, the methodology has been applied to the 3. and 13. Operational Plant State (OPS), always within the operational mode 4. Some conclusions of the analysis: The analyzed procedure requires the operability of just one charge pump as boric acid supply source. PRA gives a CDF increase (ΔCDF) of 1,19.10-6 year-1 for the pump in standby, consequently, an exposure time T= 53,6 hours. Given an average time for the OPS of 40 hours, it is concluded the correct treatment of the procedure. However, it could be improved with the inclusion of an additional inventory replacement function. This would limit the charge pump unavailability. On the other hand, the availability of the external electrical sources is ratified. The procedure requires the operability of both supplies during the OPS. The unavailability of one of them (transformer fail) involves a ΔCDF equal to 1,64.10-5 year-1 and a T= 3,89 hours. Then, it is considered appropriate the treatment

  6. Geoethical and socio-political aspects of seismic and tsunami hazard assessment, quantification and mapping

    Science.gov (United States)

    Tinti, Stefano; Armigliato, Alberto

    2016-04-01

    Seismic hazard and, more recently, tsunami hazard assessments have been undertaken in several countries of the world and globally for the whole Earth planet with the aim of providing a scientifically sound basis to the engineers, technicians, urban and industrial planners, politicians, civil protection operators and in general to the authorities for devising rational risk mitigation strategies and corresponding adequate policies. The main point of this presentation is that the chief-value of all seismic and tsunami hazard studies (including theory, concept, quantification and mapping) resides in the social and political values of the provided products, which is a standpoint entailing a number of relevant geoethical implications. The most relevant implication regards geoscientists who are the subjects mainly involved in carrying out hazard evaluations. Viewed from the classical perspective, the main ethical obligations of geoscientists are restricted to performing hazard estimations in the best possible way from a scientific point of view, which means selecting the "best" available data, adopting sound theoretical models, making use of rigorous methods… What is outlined here, is that this is an insufficient minimalistic position, since it overlooks the basic socio-political and therefore practical value of the hazard-analysis final products. In other words, if one views hazard assessment as a production process leading from data and theories (raw data and production means) to hazard maps (products), the criterion to judge whether it is good or bad needs also to include the usability factor. Seismic and tsunami hazard reports and maps are products that should be usable, which means that they should meet user needs and requirements, and therefore they should be evaluated according to how much they are clearly understandable to, and appropriate for, making-decision users. In the traditional view of a science serving the society, one could represent the interaction

  7. UPSAT guidelines. 1996 edition. Reference document for IAEA Uranium Productions Safety Assessment Teams (UPSATs)

    International Nuclear Information System (INIS)

    The IAEA Uranium Production Safety Assessment Team (UPSAT) programme provides advice and assistance to Member States to enhance the safety and environmental performance of uranium production facilities during construction, commissioning and operation. Sound design and construction are prerequisite for the safe and environmentally responsible operation of uranium mines and mills. However, the safety of the facility depends ultimately on sound policies, procedures and practices; on the capability and reliability of the construction, commissioning and operating personnel; on comprehensive instructions; and on adequate resources. A positive attitude and conscientiousness on the part of the management and staff in discharging their responsibilities is important to safety. The UPSAT guidelines have been developed in the following areas: (1) management, organization and administration; (2) training and qualification; (3) operation (4) maintenance; (5) safety, fire protection, emergency planning, and preparedness; (6) radiation protection; (7) environmental monitoring programme; (8) construction management; (9) commissioning and decommissioning

  8. Critical assessment of three high performance liquid chromatography analytical methods for food carotenoid quantification

    NARCIS (Netherlands)

    Dias, M.G.; Oliveira, L.; Camoes, M.F.G.F.C.; Nunes, B.; Versloot, P.; Hulshof, P.J.M.

    2010-01-01

    Three sets of extraction/saponification/HPLC conditions for food carotenoid quantification were technically and economically compared. Samples were analysed for carotenoids a-carotene, ß-carotene, ß-cryptoxanthin, lutein, lycopene, and zeaxanthin. All methods demonstrated good performance in the ana

  9. The guidelines project of the IOBC global WG and risk assessment of transgenic arthropods

    International Nuclear Information System (INIS)

    The guidelines project 'Development of International Scientific Biosafety Testing Guidelines for Transgenic Plants' is an international initiative of public sector scientists organized within a global Working Group on 'Transgenic Organisms in Integrated Pest Management and Biological Control' under the umbrella of the International Organization of Biological Control (IOBC). The project aims to: - develop comprehensive, transparent scientific guidelines for pre-release biosafety testing of transgenic plants, which could serve as an international standard; - extend the guidelines for possible use in post-release monitoring; - facilitate the development of the scientific capacity in developing and developed countries to implement the guidelines. - test the application the guidelines in real policy contexts to assist in the evaluation of particular transgenic crops. - publish the guidelines and periodically revise them in response to new developments thereby providing for their up-to-date, long-time use. (author)

  10. Summary guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Halsnaes, K.; Painuly, J.P.; Turkson, J.; Meyer, H.J.; Markandya, A.

    1999-09-01

    This document is a summary version of the methodological guidelines for climate change mitigation assessment developed as part of the Global Environment Facility (GEF) project Economics of Greenhouse Gas Limitations; Methodological Guidelines. The objectives of this project have been to develop a methodology, an implementing framework and a reporting system which countries can use in the construction of national climate change mitigation policies and in meeting their future reporting obligations under the FCCC. The methodological framework developed in the Methodological Guidelines covers key economic concepts, scenario building, modelling tools and common assumptions. It was used by several country studies included in the project. (au) 13 refs.

  11. Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea

    Science.gov (United States)

    Memtsoudis, Stavros G.; Ramachandran, Satya Krishna; Nagappa, Mahesh; Opperer, Mathias; Cozowicz, Crispiana; Patrawala, Sara; Lam, David; Kumar, Anjana; Joshi, Girish P.; Fleetham, John; Ayas, Najib; Collop, Nancy; Doufas, Anthony G.; Eikermann, Matthias; Englesakis, Marina; Gali, Bhargavi; Gay, Peter; Hernandez, Adrian V.; Kaw, Roop; Kezirian, Eric J.; Malhotra, Atul; Mokhlesi, Babak; Parthasarathy, Sairam; Stierer, Tracey; Wappler, Frank; Hillman, David R.; Auckley, Dennis

    2016-01-01

    The purpose of the Society of Anesthesia and Sleep Medicine guideline on preoperative screening and assessment of adult patients with obstructive sleep apnea (OSA) is to present recommendations based on the available clinical evidence on the topic where possible. As very few well-performed randomized studies in this field of perioperative care are available, most of the recommendations were developed by experts in the field through consensus processes involving utilization of evidence grading to indicate the level of evidence upon which recommendations were based. This guideline may not be appropriate for all clinical situations and all patients. The decision whether to follow these recommendations must be made by a responsible physician on an individual basis. Protocols should be developed by individual institutions taking into account the patients’ conditions, extent of interventions and available resources. This practice guideline is not intended to define standards of care or represent absolute requirements for patient care. The adherence to these guidelines cannot in any way guarantee successful outcomes and is rather meant to help individuals and institutions formulate plans to better deal with the challenges posed by perioperative patients with OSA. These recommendations reflect the current state of knowledge and its interpretation by a group of experts in the field at the time of publication. While these guidelines will be periodically updated, new information that becomes available between updates should be taken into account. Deviations in practice from guidelines may be justifiable and such deviations should not be interpreted as a basis for claims of negligence. PMID:27442772

  12. Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea.

    Science.gov (United States)

    Chung, Frances; Memtsoudis, Stavros G; Ramachandran, Satya Krishna; Nagappa, Mahesh; Opperer, Mathias; Cozowicz, Crispiana; Patrawala, Sara; Lam, David; Kumar, Anjana; Joshi, Girish P; Fleetham, John; Ayas, Najib; Collop, Nancy; Doufas, Anthony G; Eikermann, Matthias; Englesakis, Marina; Gali, Bhargavi; Gay, Peter; Hernandez, Adrian V; Kaw, Roop; Kezirian, Eric J; Malhotra, Atul; Mokhlesi, Babak; Parthasarathy, Sairam; Stierer, Tracey; Wappler, Frank; Hillman, David R; Auckley, Dennis

    2016-08-01

    The purpose of the Society of Anesthesia and Sleep Medicine guideline on preoperative screening and assessment of adult patients with obstructive sleep apnea (OSA) is to present recommendations based on the available clinical evidence on the topic where possible. As very few well-performed randomized studies in this field of perioperative care are available, most of the recommendations were developed by experts in the field through consensus processes involving utilization of evidence grading to indicate the level of evidence upon which recommendations were based. This guideline may not be appropriate for all clinical situations and all patients. The decision whether to follow these recommendations must be made by a responsible physician on an individual basis. Protocols should be developed by individual institutions taking into account the patients' conditions, extent of interventions and available resources. This practice guideline is not intended to define standards of care or represent absolute requirements for patient care. The adherence to these guidelines cannot in any way guarantee successful outcomes and is rather meant to help individuals and institutions formulate plans to better deal with the challenges posed by perioperative patients with OSA. These recommendations reflect the current state of knowledge and its interpretation by a group of experts in the field at the time of publication. While these guidelines will be periodically updated, new information that becomes available between updates should be taken into account. Deviations in practice from guidelines may be justifiable and such deviations should not be interpreted as a basis for claims of negligence. PMID:27442772

  13. Xinhe Mine water inrush risk assessment based on quantification theoretical models

    Institute of Scientific and Technical Information of China (English)

    LI Hui; JING Guo-xun; CAI Zheng-long; OU Jian-chun

    2010-01-01

    Taking the Xinhe mine's structure, mine pressure, structural fissure, fault and fault displacement, the distance between fault and water inrush point, thickness of block,water pressure those geological factors which influenced the water inrush as the independent variable, based on these data of water inrush point and water uninrush point, using the method of quantification theory( Ⅰ, Ⅱ ), it would quantitatively disposes the qualitative variable, applied to calculation to evaluate the risk of Xinhe's water inrush.

  14. Is biofilm removal properly assessed? Comparison of different quantification methods in a 96-well plate system

    OpenAIRE

    Stiefel, Philipp; Rosenberg, Urs; Schneider, Jana; Mauerhofer, Stefan; Maniura-Weber, Katharina; Ren, Qun

    2016-01-01

    Various methods have been reported to quantify total biofilm or different components of biofilm; however, these methods are often confusedly used, leading to discrepancies and misleading results. In this study, different methods for quantification of biofilm, including those for total biomass, total amount of bacterial cells, viable cell number, and amount of extracellular polymeric substances, were systematically compared in microtiter plates. To evaluate which method is suitable for assessm...

  15. Guideline development and impact assessment for registration of medical, dental and veterinary x-ray apparatus

    International Nuclear Information System (INIS)

    Under the NSW Radiation Control Act 1990, radiation apparatus used for diagnostic medical, dental and veterinary purposes will be required to become registered. The inspection required prior to registration will be conducted by a Consulting Radiation Expert who has been accredited by the Environment Protection Authority (EPA) as being competent in the field of quality assurance assessment of radiation apparatus used for diagnostic medical, dental and veterinary purposes. When regulating any activity in NSW, there is a requirement to undertake a regulatory impact statement of the proposed regulation. In addition, the introduction of any accompanying guideline requires a cost-benefit analysis. Costs may include enforcement, administrative and compliance activities. The calculation of benefit relies heavily on the improvement in apparatus performance (and hence dose reduction) that can be obtained with the introduction of a mandatory practice such as apparatus registration. This paper discusses the development of the registration guideline for NSW, including a summary of the public comments received. It further discusses the methodology and data used for the accompanying cost-benefit analysis. Information in this paper is presented in three parts: EPA field survey, cost analysis, and benefit analysis. For NSW it was estimated that the introduction of registration of these apparatus, over a two year period, would result in early replacement and repair costs (present values) to the medical industry of between $5.7 and $11.0 million, with an additional $2.5 million in EPA enforcement costs. The introduction of the proposed system of registration is expected to result in an estimated savings in quantifiable health detriment costs to NSW of between $11.8 and $17.7 million, and reduce the risk of radiation induced mortality. (authors)

  16. Infant Mental Health Assessment and Intervention Guidance for Service Providers and Families of Young Children. Service Guideline 4.

    Science.gov (United States)

    Connecticut Birth to Three System, Hartford.

    This guide offers assessment and intervention guidelines for the Connecticut Birth to Three system concerning the emotional and psychological well-being of infants and toddlers in the system. Emphasis is on infants and toddlers who exhibit symptoms of traumatic stress disorder, depression or other affective disorders, regulatory disorders, sleep…

  17. Spanish guideline for the definition and assessment of risk-informed inservice inspection programs for piping

    International Nuclear Information System (INIS)

    The recent emphasis on risk-informed in-service inspection has been taken on by the Spanish Utilities and the Spanish Regulatory Body in their proposal for a co-operation project for defining a Risk-Informed In-Service Inspection Guideline for Piping. This paper describes first the main features of this Spanish guideline and then the results of the pilot applications developed in order to check the consistency of the guideline. (authors)

  18. Reliability and accuracy assessment of radiation therapy oncology group-endorsed guidelines for brachial plexus contouring

    Energy Technology Data Exchange (ETDEWEB)

    Velde, Joris van de [Ghent University, Department of Anatomy, Ghent (Belgium); Ghent University, Department of Radiotherapy, Ghent (Belgium); Vercauteren, Tom; Gersem, Werner de; Vandecasteele, Katrien; Vuye, Philippe; Vanpachtenbeke, Frank; Neve, Wilfried de [Ghent University, Department of Radiotherapy, Ghent (Belgium); Wouters, Johan; Herde, Katharina d' ; Kerckaert, Ingrid; Hoof, Tom van [Ghent University, Department of Anatomy, Ghent (Belgium)

    2014-07-15

    The goal of this work was to validate the Radiation Therapy Oncology Group (RTOG)-endorsed guidelines for brachial plexus (BP) contouring by determining the intra- and interobserver agreement. Accuracy of the delineation process was determined using anatomically validated imaging datasets as a gold standard. Five observers delineated the right BP on three cadaver computed tomography (CT) datasets. To assess intraobserver variation, every observer repeated each delineation three times with a time interval of 2 weeks. The BP contours were divided into four regions for detailed analysis. Inter- and intraobserver variation was verified using the Computerized Environment for Radiation Research (CERR) software. Accuracy was measured using anatomically validated fused CT-magnetic resonance imaging (MRI) datasets by measuring the BP inclusion of the delineations. The overall kappa (κ) values were rather low (mean interobserver overall κ: 0.29, mean intraobserver overall κ: 0.45), indicating poor inter- and intraobserver reliability. In general, the κ coefficient decreased gradually from the medial to lateral BP regions. The total agreement volume (TAV) was much smaller than the union volume (UV) for all delineations, resulting in a low Jaccard index (JI; interobserver agreement 0-0.124; intraobserver agreement 0.004-0.636). The overall accuracy was poor, with an average total BP inclusion of 38 %. Inclusions were insufficient for the most lateral regions (region 3: 21.5 %; region 4: 12.6 %). The inter- and intraobserver reliability of the RTOG-endorsed BP contouring guidelines was poor. BP inclusion worsened from the medial to lateral regions. Accuracy assessment of the contours showed an average BP inclusion of 38 %. For the first time, this was assessed using the original anatomically validated BP volume. The RTOG-endorsed BP guidelines have insufficient accuracy and reliability, especially for the lateral head-and-neck regions. (orig.) [German] Ziel der Studie war

  19. Disease quantification in dermatology: in vivo near-infrared spectroscopy measures correlate strongly with the clinical assessment of psoriasis severity

    Science.gov (United States)

    Greve, Tanja Maria; Kamp, Søren; Jemec, Gregor B. E.

    2013-03-01

    Accurate documentation of disease severity is a prerequisite for clinical research and the practice of evidence-based medicine. The quantification of skin diseases such as psoriasis currently relies heavily on clinical scores. Although these clinical scoring methods are well established and very useful in quantifying disease severity, they require an extensive clinical experience and carry a risk of subjectivity. We explore the opportunity to use in vivo near-infrared (NIR) spectra as an objective and noninvasive method for local disease severity assessment in 31 psoriasis patients in whom selected plaques were scored clinically. A partial least squares (PLS) regression model was used to analyze and predict the severity scores on the NIR spectra of psoriatic and uninvolved skin. The correlation between predicted and clinically assigned scores was R=0.94 (RMSE=0.96), suggesting that in vivo NIR provides accurate clinical quantification of psoriatic plaques. Hence, NIR may be a practical solution to clinical severity assessment of psoriasis, providing a continuous, linear, numerical value of severity.

  20. Assessment of the real-time PCR and different digital PCR platforms for DNA quantification

    OpenAIRE

    Pavšič, Jernej; Žel, Jana; Milavec, Mojca

    2015-01-01

    Digital PCR (dPCR) is beginning to supersede real-time PCR (qPCR) for quantification of nucleic acids in many different applications. Several analytical properties of the two most commonly used dPCR platforms, namely the QX100 system (Bio-Rad) and the 12.765 array of the Biomark system (Fluidigm), have already been evaluated and compared with those of qPCR. However, to the best of our knowledge, direct comparison between the three of these platforms using the same DNA material has not been do...

  1. Radon Quantification and epidemiological assessment in room environments, according to construction material

    International Nuclear Information System (INIS)

    This work deals with the quantification of radon concentrations en the Ecuadorian region called 'Sierra', the contribution of building materials to the radioactive contamination and the rooms with greatest contents of radon and his daughters. The most representative zones are: Cuenca, Riobamba, San Gabriel and Puyango, this means that per m3 of air 429.14 radon atoms decay in a second to Po-218, the analyzed materials were: cement, black stone, bricks the rooms: bedroom, hall, dining room and bethroom. Knowing the biological damage that occurs by interaction of a particles with lung tissues. We suggest the follow research in order to get the average concentration for every province

  2. ICF linked Dutch physiotherapy guidelines concerning initial assessment, treatment and evaluation in hip and knee osteoarthritis.

    NARCIS (Netherlands)

    Peter, W.; Jansen, M.J.; Hurkmans, E.J.; Bloo, H.; Dekker-Bakker, L.M.M.C.J.; Dilling, R.G.; Hilberdink, W.K.H.A.; Kersten-Smit, C.; Rooij, M. de; Veenhof, C.; Vermeulen, E.M.; Vos, I. de; Schoones, J.W.; Vliet Vlieland, T.P.

    2011-01-01

    Purpose: In 2001 the Royal Dutch Society for Physical Therapy (KNGF) Guideline for hip and knee osteoarthritis (HKOA) was developed. Since then, many scientific papers on physical therapy interventions as well as national and international guidelines were published. Relevance: An update of the physi

  3. Application of OECD Guideline 423 in assessing the acute oral toxicity of moniliformin.

    Science.gov (United States)

    Jonsson, Martina; Jestoi, Marika; Nathanail, Alexis V; Kokkonen, Ulla-Maija; Anttila, Marjukka; Koivisto, Pertti; Karhunen, Pirkko; Peltonen, Kimmo

    2013-03-01

    Moniliformin is a Fusarium mycotoxin highly prevalent in grains and grain-based products worldwide. In this study, the acute oral toxicity of moniliformin was assessed in Sprague-Dawley male rats according to OECD Guideline 423 with a single-dose exposure. Clinical observations and histopathological changes were recorded together with the excretion of moniliformin via urine and feces, utilizing a novel liquid chromatography-mass spectrometry method. According to our study, moniliformin is acutely toxic to rats with a rather narrow range of toxicity. Moniliformin can be classified into category 2 (LD(50) cut-off value 25 mg/kg b.w.), according to the Globally Harmonized System for the classification of chemicals. The clinical observations included muscular weakness, respiratory distress and heart muscle damage. Pathological findings confirmed that heart is the main target tissue of acute moniliformin toxicity. A significant proportion (about 38%) of the administered moniliformin was rapidly excreted in urine in less than 6 h. However, the toxicokinetics of the majority of the administered dose still requires clarification, as the total excretion was only close to 42%. Considering the worldwide occurrence of moniliformin together with its high acute toxicity, research into the subchronic toxicity is of vital importance to identify the possible risk in human/animal health. PMID:23201451

  4. Dose assessment by quantification of chromosome aberrations and micronuclei in peripheral blood lymphocytes from patients exposed to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Silva-Barbosa, Isvania; Pereira-MagnataI, Simey; Amaral, Ademir [Pernambuco Univ., Recife, PE (Brazil). Dept. de Energia Nuclear. Grupo de Estudos em Radioprotecao e Radioecologia - GERAR; Sotero, Graca [Fundacao de Hematologia e Hemoterapia, Recife, PE (Brazil); Melo, Homero Cavalcanti [Hospital do Cancer, Recife, PE (Brazil). Centro de Radioterapia de Pernambuco]. E-mail: isvania@uol.com.br

    2005-07-15

    Scoring of unstable chromosome aberrations (dicentrics, rings and fragments) and micronuclei in circulating lymphocytes are the most extensively studied biological means for estimating individual exposure to ionizing radiation (IR), which can be used as complementary methods to physical dosimetry or when the latter cannot be performed. In this work, the quantification of the frequencies of chromosome aberrations and micronuclei were carried out based on cytogenetic analyses of peripheral blood samples from 5 patients with cervical uterine cancer following radiotherapy in order to evaluate the absorbed dose as a result of partial-body exposure to 60Co source. Blood samples were collected from each patient in three phases of the treatment: before irradiation, 24 h after receiving 0.08 Gy and 1.8 Gy, respectively. The results presented in this report emphasize biological dosimetry, employing the quantification of chromosome aberrations and micronuclei in lymphocytes from peripheral blood, as an important methodology of dose assessment for either whole or partial-body exposure to IR.

  5. SCART guidelines. Reference report for IAEA Safety Culture Assessment Review Team (SCART)

    International Nuclear Information System (INIS)

    The IAEA Director General stressed the role of safety culture in his concluding remarks at the Meeting of the Contracting Parties to the Convention on Nuclear Safety in 2002: 'As we have learned in other areas, it is not enough simply to have a structure; it is not enough to say that we have the necessary laws and the appropriate regulatory bodies. All these are important, but equally important is that we have in place a safety culture that gives effect to the structure that we have developed. To me, effectiveness and transparency are keys. So, it is an issue which I am pleased to see, you are giving the attention it deserves and we will continue to work with you in clarifying, developing and applying safety culture through our programmes and through our technical cooperation activities.' The concept of safety culture was initially developed by the International Nuclear Safety Advisory Group (INSAG) after the Chernobyl accident in 1986. Since then the IAEA's perspective of safety culture has expanded with time as its recognition of the complexities of the concept developed. Safety culture is considered to be specific organizational culture in all types of organizations with activities that give rise to radiation risks. The aim is to make safety culture strong and sustainable, so that safety becomes a primary focus for all activities in such organizations, even for those, which might not look safety-related at first. SCART (Safety Culture Assessment Review Team) is a safety review service, which reflects the expressed interest of Members States for methods and tools for safety culture assessment. It is a replacement for the earlier service ASCOT (Assessment of Safety Culture in Organizations Team). The IAEA Safety Fundamentals, Requirements and Guides (Safety Standards) are the basis for the SCART Safety Review Service. The reports of INSAG, identifying important current nuclear safety issues, serve also as references during a SCART mission. SCART missions are based

  6. GEOTHERMAL ENVIRONMENTAL IMPACT ASSESSMENT: GROUND WATER MONITORING GUIDELINES FOR GEOTHERMAL DEVELOPMENT

    Science.gov (United States)

    This report discusses potential ground water pollution from geothermal resource development, conversion, and waste disposal, and proposes guidelines for developing a ground water monitoring plan for any such development. Geothermal processes, borehole logging, and injection well ...

  7. Molecular and Serological Assessment of Chronic HBV Carriers and Additional Burden of Applying Updated Guidelines in Pakistan

    International Nuclear Information System (INIS)

    Objective: To assess the additional burden of the patients eligible for treatment, based on recommendations on viral load, in the light of 2009 version of AASLD guidelines, as compared to 2004 guidelines and to determine the frequency of HBeAg in chronic HBV carriers. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Virology Department, Armed Forces Institute of Pathology, Rawalpindi, from November 2010 to January 2012. Methodology: Persons with chronic HBV infection, reporting for HBV DNA PCR test, were included in the study and blood samples were collected. HBV DNA load was determined by Real Time PCR. HBsAg and HBeAg were tested by ELISA. Results: Out of the 801 subjects positive for HBsAg, 74 (9.24%) were positive for HBeAg. Out of them, 113 (14.1%) had HBV DNA load > 100,000 copies/ml and were eligible for treatment according to AASLD 2004 guidelines. Forty one (5.1%) had HBV load between 10,000 and 100,000 copies/ml, and were additionally eligible for treatment as per AASLD 2009 guidelines. The 5.1% of 4.5 million estimated HBV carries in Pakistan comes to 229500. Conclusion: There was a low HBeAg positivity and HBV DNA positivity in our chronic HBV infected persons. Moreover, there is an increase of 229500 potential candidates for HBV treatment in Pakistan based on viral load testing, according to the AASLD 2009 guidelines when compared with 2004 guidelines. The increase in the number of candidates for treatment may require an additional expenditure of tens of billions of rupees. (author)

  8. An assessment of clinical guidelines for the management of acute pancreatitis.

    OpenAIRE

    S. A. Norton; Cheruvu, C. V.; Collins, J.; Dix, F. P.; Eyre-Brook, I. A.

    2001-01-01

    BACKGROUND: Recent guidelines have been issued for the management of acute pancreatitis. The aim of this study was to audit the management of acute pancreatitis in one district general hospital, to determine the problems and benefits associated with the implementation of such guidelines. METHODS: Data were collected over the period 1991-1995 for all patients diagnosed as having acute pancreatitis who were admitted to one district general hospital. Data regarding severity grading, determinatio...

  9. Caries risk assessment in young adults using Public Dental Service guidelines and the Cariogram-a comparative study

    DEFF Research Database (Denmark)

    Hänsel Petersson, Gunnel; Ericson, Ewa; Isberg, Per-Erik; Twetman, Svante

    2012-01-01

    Abstract Objectives. To investigate the caries risk profiles in young adults and to compare the risk classification using the Public Dental Service (PDS) guidelines with a risk assessment program, the Cariogram. Materials and methods. All 19-year-old patients registered at eight public dental...... to the PDS guidelines. A research team collected whole saliva samples and information from a questionnaire and a structured interview in order to calculate risk according to the Cariogram model. Results. The mean DFS value was 4.9 and 23% of the patients were registered as caries-free (DFS = 0). The...... PDS risk classification was predominantly based on past caries and/or present caries activity. The majority was classified as 'some risk', while 16.7% were assessed as being of 'high' or 'very high risk'. The corresponding value for the two highest risk groups in the Cariogram model was 17.4%. The...

  10. Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea.

    OpenAIRE

    Chung, F; Memtsoudis, SG; Ramachandran, SK; Nagappa, M; Opperer, M; Cozowicz, C; Patrawala, S; Lam, D.; Kumar, A; Joshi, GP; Fleetham, J; Ayas, N; Collop, N; Doufas, AG; Eikermann, M

    2016-01-01

    The purpose of the Society of Anesthesia and Sleep Medicine guideline on preoperative screening and assessment of adult patients with obstructive sleep apnea (OSA) is to present recommendations based on the available clinical evidence on the topic where possible. As very few well-performed randomized studies in this field of perioperative care are available, most of the recommendations were developed by experts in the field through consensus processes involving utilization of evidence grading...

  11. ASCOT guidelines

    International Nuclear Information System (INIS)

    These guidelines describe an approach used in conducting an Assessment of Safety Culture in Organizations Team (ASCOT) review. They are intended to assist the team members in conducting their reviews and at the same time provide guidance to hosts preparing to receive an ASCOT review. They may also be used by any organization wishing to conduct their own self-assessment of safety culture, independent of an ASCOT review

  12. Prevailing Practice Versus Clinical Guideline: The In-Patient Assessment And Management Of Childhood Bronchopneumonia In A Malaysian District Hospital

    Directory of Open Access Journals (Sweden)

    Jacynta Jayaram

    2008-12-01

    Full Text Available Introduction: Pneumonia is the most commondiagnosis made in hospitalised children. The MalaysianClinical Practice Guidelines on pneumonia andrespiratory tract infections provides a comprehensiveguidance in the local context. We evaluated thedocumented assessment and management of childrendiagnosed with pneumonia admitted to the children’sward, Hospital Batu Pahat against this guideline.Methods: We performed a retrospective analysis ofhospital case notes for children admitted from Januaryto May 2004.Results: Ninety six case notes were analysed. Mostpatients (84% had at least four positive clinical featuresleading to the diagnosis of pneumonia. 92% met theguideline criteria for admission. Sp02 was performed for58% on admission, and 58% with reading below 95%received supplemental oxygen. Throughout hospitalstay, each patient had an average of four investigations(range: 1 – 12. Among 23 patients who hadfurther investigations, justifications were only recordedin seven patients (30.4%, and changes inmanagement resulted in 23%. The most commonantibiotic prescribed was intravenous Penicillin (97 %.In 17 patients who met the guideline classification forsevere pneumonia, none received the recommendedantibiotic combination. The median time to feverresolution was 22 hours (range 2 – 268, and medianhospital stay was 3 days (range 1 – 12.Conclusions: Although the quality of clinicalassessment and antibiotic choices were acceptable,there was a failure to critically evaluate patientsaccording to disease severity and initiate correspondinginvestigations and managements. Future efforts need tobe directed at promoting further guideline adherenceand the exercise of critical judgment in patientevaluation.

  13. Availability, content and quality of local guidelines for the assessment of suicide attempters in university and general hospitals in the Netherlands.

    NARCIS (Netherlands)

    Verwey, B.; Waarde, J.A. van; Rooij, I.A.L.M. van; Gerritsen, G.; Zitman, F.G.

    2006-01-01

    OBJECTIVE: This study was performed to investigate the availability, content and quality of local guidelines for the assessment of suicide attempters in the Netherlands. METHOD: All university and general hospitals in the Netherlands were asked to provide their local guidelines. Published national g

  14. Development of the Stroke-unit Discharge Guideline: choice of assessment instruments for prediction in the subacute phase post-stroke

    NARCIS (Netherlands)

    R. Meijer; J. van Limbeek; R. de Haan

    2006-01-01

    The purpose of this paper is to present the design of an evidence-based dataset of assessment instruments for the prognostic factors of the Stroke-unit Discharge Guideline (SDG), a consensus based guideline for the decision of the discharge destination from the hospital stroke unit. In our systemati

  15. Development of the Stroke-unit Discharge Guideline: choice of assessment instruments for prediction in the subacute phase post-stroke.

    NARCIS (Netherlands)

    Meijer, R.; Limbeek, J. van; Haan, R. de

    2006-01-01

    The purpose of this paper is to present the design of an evidence-based dataset of assessment instruments for the prognostic factors of the Stroke-unit Discharge Guideline (SDG), a consensus based guideline for the decision of the discharge destination from the hospital stroke unit. In our systemati

  16. Reliable Assessment and Quantification of the Fluorescence-Labeled Antisense Oligonucleotides In Vivo

    Directory of Open Access Journals (Sweden)

    Maria Chiara Munisso

    2014-01-01

    Full Text Available The availability of fluorescent dyes and the advances in the optical systems for in vivo imaging have stimulated an increasing interest in developing new methodologies to study and quantify the biodistribution of labeled agents. However, despite these great achievements, we are facing significant challenges in determining if the observed fluorescence does correspond to the quantity of the dye in the tissues. In fact, although the far-red and near-infrared lights can propagate through several centimetres of tissue, they diffuse within a few millimetres as consequence of the elastic scattering of photons. In addition, when dye-labeled oligonucleotides form stable complex with cationic carriers, a large change in the fluorescence intensity of the dye is observed. Therefore, the measured fluorescence intensity is altered by the tissue heterogeneity and by the fluctuation of dye intensity. Hence, in this study a quantification strategy for fluorescence-labeled oligonucleotides was developed to solve these disadvantageous effects. Our results proved that upon efficient homogenization and dilution with chaotropic agents, such as guanidinium thiocyanate, it is possible to achieve a complete fluorescence intensity recovery. Furthermore, we demonstrated that this method has the advantage of good sensitivity and reproducibility, as well as easy handling of the tissue samples.

  17. DCE-MRI and DWI Integration for Breast Lesions Assessment and Heterogeneity Quantification

    Directory of Open Access Journals (Sweden)

    C. Andrés Méndez

    2012-01-01

    Full Text Available In order to better predict and follow treatment responses in cancer patients, there is growing interest in noninvasively characterizing tumor heterogeneity based on MR images possessing different contrast and quantitative information. This requires mechanisms for integrating such data and reducing the data dimensionality to levels amenable to interpretation by human readers. Here we propose a two-step pipeline for integrating diffusion and perfusion MRI that we demonstrate in the quantification of breast lesion heterogeneity. First, the images acquired with the two modalities are aligned using an intermodal registration. Dissimilarity-based clustering is then performed exploiting the information coming from both modalities. To this end an ad hoc distance metric is developed and tested for tuning the weighting for the two modalities. The distributions of the diffusion parameter values in subregions identified by the algorithm are extracted and compared through nonparametric testing for posterior evaluation of the tissue heterogeneity. Results show that the joint exploitation of the information brought by DCE and DWI leads to consistent results accounting for both perfusion and microstructural information yielding a greater refinement of the segmentation than the separate processing of the two modalities, consistent with that drawn manually by a radiologist with access to the same data.

  18. Sugar Variation in Soybean Seed Assessed with a Rapid Extraction and Quantification Method

    Directory of Open Access Journals (Sweden)

    A. Hou

    2009-01-01

    Full Text Available Sugar content in soybean [Glycine max (L Merr.] seed is an important quality attribute for soyfood and feed. Rapid extraction and quantification of soluble sugars in soybean seed are essential for large-scale breeding selections. In this study, using water as extractant combined with a high-performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD system, variability and repeatability of sugar content were tested in 20 diverse soybean genotypes. Individual sugars were clearly resolved and identified, including sucrose, stachyose, raffinose, glucose, fructose, and verbascose. Analysis of variance (ANOVA revealed a highly reproducible estimation of sucrose, stachyose, and raffinose. PI 243545 was confirmed as a unique germplasm with the highest sucrose (105.48 mg/g and total sugar (148.76 mg/g content. Two low-oligosaccharide accessions, PI 200508 and 03CB-14, were confirmed with extremely low concentrations of raffinose and stachyose. PI 417559 was identified as a high glucose and fructose germplasm. The identified germplasm with unique sugar profiles will be valuable in breeding specialty soybeans for improved sugar content. The sugar testing method will facilitate the screening of seed sugar profiles in a large-scale soybean breeding program.

  19. Assessment of radiological referral practice and effect of computer-based guidelines on radiological requests in two emergency departments

    International Nuclear Information System (INIS)

    AIM: To assess medical emergency radiology referral practice compared with a set of French guidelines and to measure the efficiency of computer-based guidelines on unnecessary medical imaging. MATERIALS AND METHODS: All radiological requests were computerized in the medical emergency departments of two French teaching hospitals. During control periods, radiological requests were recorded but no action was taken. During intervention periods, reminder displays on screen indicated the appropriate recommendations. Three control and three intervention periods of 1 month each were conducted. The percentage of requests that did not conform to the guidelines and variation related to periods of control and intervention were measured. RESULTS: The proportion of requests that did not conform to the guidelines was 33·2% when the guidelines were inactive and decreased to 26·9% when the recommendations were active (P < 0·0001). The three imaging examinations (chest radiographs, abdominal plain radiographs and CT of the brain) accounted for more than 80% of all requests; more than 50% of abdominal plain radiographs requests did not conform with recommendations while this percentage was respectively 24·9% and 15·8% for chest radiographs and computed tomography (CT) of the brain. Seven situations accounted for 70% of non-conforming radiological referrals; in these situations, junior practitioners' knowledge was inadequate. CONCLUSION: While the computer provided advice that was tailored to the needs of individual patients, concurrent with care, the effect of our intervention was weak. However, our study identified the few situations that were responsible for the majority of unnecessary radiological requests; we expect that this result could help clinicians and radiologists to develop more specific actions for these situations. Carton, M. et al. (2002). Clinical Radiology (2002)

  20. Microfacies quantification: Assessing component diversity among circumalpine Paleogene and Neogene carbonates

    Science.gov (United States)

    Nebelsick, James; Bassi, Davide; Florian, Nitsch; Tobias, Grun

    2015-04-01

    Quantification of highly cemented shallow-water marine carbonates allows for the analysis of component and facies distributions along environmental and paleogeographic gradients as well as between time slices. The analyzed data is gained by point counting of numerous thin sections from a wide spectrum of stratigraphical profiles. The limitations of such analysis lie in the wide range of taxonomic ranks that can be distinguished in thin section ranging from species to phylum level. Identification to taxonomic rank depends on the presence diagnostic morphological features, preservation potentials as distinguished by microtaphofacies analysis as well as diagenetic trajectories of differential shell mineralogies. It is also explored how taxonomic resolution is affected by factors affecting facies distribution patterns such as terrigenous input or exposure gradients on the carbonate ramps. Bivariate analysis including component relationships can be discerned with correlations suggesting similar or divergent ecological requirements or direct dependencies such as substrate relationships. These analyses also allow the ecology of subordinate components to be explored. Multivariate analyses distinguish microfacies types based on component distributions with facies characterized by the respective dominant component or components. The quantified data of thin sections originate from detailed studies of carbonates from three time slices (Early Oligocene, Late Oligocene and Early Miocene) carbonates from the circumalpine area including localities south (Northern Italy, Slovenia) and north (Southern Germany, Austria) of the Alps. These time periods are of interest due to variations in local environmental variations including terrigenous influx, regional paleogeographic developments within the Mediterranean Tethys and Paratethys as well as global climatic change. Lower Oligocene sediments show mud rich deposits dominated by coralline algae, larger foraminifera including Nummulites

  1. Virtual Touch tissue quantification cannot assess breast cancer lesions except for ductal carcinomas in situ and small invasive cancers: a retrospective study

    OpenAIRE

    Tada, Keiichiro; Nishioka, Kotoe; Kikuchi, Yasuko; Niwa, Takayoshi; Seto, Yasuyuki

    2015-01-01

    Background Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue. However, the clinical impact of this device on the assessment of breast cancer is unclear. Methods This study aimed to review the ultrasound records of patients with breast lesions where VTTQ was used to assess 123 normal breast tissues, 18 benign tumors, and 117 histopathologically confirmed breast cancers in a total of 129 patients. To determine the VTT...

  2. Best practice guidelines for the use of the assessment centre method in South Africa (5th edition

    Directory of Open Access Journals (Sweden)

    Deon Meiring

    2016-04-01

    Full Text Available Orientation: Assessment Centres (ACs have a long and successful track record in South Africa when used for selection and development purposes. The popularity of the approach is mainly attributable to the ACs’ numerous strengths, which include the perceived fairness, practical utility and strong associations with on-the-job performance. To maintain the integrity of the AC, it is important for practitioners and decision makers to apply the method in a consistent and standardised manner.Research purpose: The purpose of the report is to provide practitioners and decision makers with practical guidelines and concrete procedures when using ACs as part of the organisation’s human resource management strategy. Motivation for the study: The past decade has seen significant advances in the science and practice of ACs. Now in its fifth edition, the revised Guidelines seek to provide important information to practitioners and decision makers on a number of factors when used in conjunction with the AC method, namely, technology, validation, legislation, ethics and culture.Main findings: The Guidelines provide specific suggestions and recommendations for using technology as part of the manner of delivery. Issues of culture, diversity and representation are also discussed. New features of the Guidelines include more concrete guidance on how to conduct a validation study as well as unpacking several ethical dilemmas that practitioners may encounter. Of critical importance is a position statement on the use of ACs in relation to new legislation (Employment Equity Amendment Act, Section 8, clause d pertaining to psychometric testing.Practical/managerial implications: The Guidelines serve as a benchmark of best practice for practitioners and decision makers who intend on, or are currently, using ACs in their organisations.Contribution/value-add: In the absence of formal standards governing the use of ACs in South Africa, the Guidelines provide an important

  3. Updated Guidelines for the Medical Assessment and Care of Children Who May Have Been Sexually Abused.

    Science.gov (United States)

    Adams, Joyce A; Kellogg, Nancy D; Farst, Karen J; Harper, Nancy S; Palusci, Vincent J; Frasier, Lori D; Levitt, Carolyn J; Shapiro, Robert A; Moles, Rebecca L; Starling, Suzanne P

    2016-04-01

    The medical evaluation is an important part of the clinical and legal process when child sexual abuse is suspected. Practitioners who examine children need to be up to date on current recommendations regarding when, how, and by whom these evaluations should be conducted, as well as how the medical findings should be interpreted. A previously published article on guidelines for medical care for sexually abused children has been widely used by physicians, nurses, and nurse practitioners to inform practice guidelines in this field. Since 2007, when the article was published, new research has suggested changes in some of the guidelines and in the table that lists medical and laboratory findings in children evaluated for suspected sexual abuse and suggests how these findings should be interpreted with respect to sexual abuse. A group of specialists in child abuse pediatrics met in person and via online communication from 2011 through 2014 to review published research as well as recommendations from the Centers for Disease Control and Prevention and the American Academy of Pediatrics and to reach consensus on if and how the guidelines and approach to interpretation table should be updated. The revisions are based, when possible, on data from well-designed, unbiased studies published in high-ranking, peer-reviewed, scientific journals that were reviewed and vetted by the authors. When such studies were not available, recommendations were based on expert consensus. PMID:26220352

  4. New guidelines for diagnosis of gestational diabetes: Pathology-based impact assessment

    Directory of Open Access Journals (Sweden)

    Ezekiel Uba Nwose

    2013-01-01

    Full Text Available Background: A recent study indicated an average of 19.5% abnormal oral glucose tolerance in antenatal clients per year. Aim: The purpose of this study was to determine the impact on gestational diabetes cases due to new guidelines for diagnosis and classification of hyperglycaemia in pregnancy. Materials and Methods: This study reviewed the archived clinical pathology data on oral glucose tolerance tests performed between January 1999 and December 2008 on antenatal clients ( N = 615. The cases were reviewed to determine changes if any in percentage of gestational diabetes due to new guidelines. Results: Over the 10 years period, a yearly average of additional 10.8% antenatal cases suggestive of gestational diabetes was observed due to the new recommended thresholds. Further, the average yearly incidence would have increased from 8.8 cases to 16.2 cases, which translates to almost 46% increase in the prospective numbers of gestational diabetes. Conclusions: This report presents the extent of how the new recommended guidelines for diagnosis and classification of hyperglycaemia in pregnancy could increase the prevalence of gestational diabetes. It also provides pathology-based evidence for the epidemiology of gestational diabetes mellitus and allows for planning the costs that would be attendant to the full implementation of the new guidelines.

  5. Quantification of urban metabolism through coupling with the life cycle assessment framework: concept development and case study

    International Nuclear Information System (INIS)

    Cities now consume resources and produce waste in amounts that are incommensurate with the populations they contain. Quantifying and benchmarking the environmental impacts of cities is essential if urbanization of the world’s growing population is to occur sustainably. Urban metabolism (UM) is a promising assessment form in that it provides the annual sum material and energy inputs, and the resultant emissions of the emergent infrastructural needs of a city’s sociotechnical subsystems. By fusing UM and life cycle assessment (UM–LCA) this study advances the ability to quantify environmental impacts of cities by modeling pressures embedded in the flows upstream (entering) and downstream (leaving) of the actual urban systems studied, and by introducing an advanced suite of indicators. Applied to five global cities, the developed UM–LCA model provided enhanced quantification of mass and energy flows through cities over earlier UM methods. The hybrid model approach also enabled the dominant sources of a city’s different environmental footprints to be identified, making UM–LCA a novel and potentially powerful tool for policy makers in developing and monitoring urban development policies. Combining outputs with socioeconomic data hinted at how these forces influenced the footprints of the case cities, with wealthier ones more associated with personal consumption related impacts and poorer ones more affected by local burdens from archaic infrastructure. (letter)

  6. Assessment of local deformation using EBSD: Quantification of accuracy of measurement and definition of local gradient

    International Nuclear Information System (INIS)

    Electron backscatter diffraction (EBSD) in conjunction with scanning electron microscopy was used to assess the magnitude of microstructural scale deformation (local deformation) for deformed Type 316 stainless steel. Local misorientation, which is an averaged misorientation between neighboring measurement points, is often used for assessment of local deformation. However, the local misorientation is unsuitable for a quantitative evaluation because it depends not only on the local deformation but also on various factors such as measurement accuracy and the distance between points used in the misorientation calculation (step size). In this study, first, the measurement accuracy was quantified by a parameter called background noise. The factors which affect the measurement accuracy were then discussed from measurements under various conditions. Secondly, in order to reduce the influence of measurement conditions and exclude the dependency of step size in the local deformation assessment, a parameter called the local gradient GL was proposed. The local gradient clearly showed the spatial distribution of local deformation regardless of the measurement accuracy, and it had hardly any effect from grid pattern and step size. Finally, the local gradient was correlated with the plastic strain from which it was revealed that the strain gradient near a notch root could be estimated by the EBSD measurement. -- Research highlights: → The accuracy of EBSD measurement was quantified for representing quality of measurement. → A parameter called the local gradient was proposed for assessment of crystal lattice curvature. → The local gradient was correlated with plastic strain and used for quantifying localized strain.

  7. [Clinical practice guidelines for assessment and treatment of transsexualism. SEEN Identity and Sexual Differentiation Group (GIDSEEN)].

    Science.gov (United States)

    Moreno-Pérez, Oscar; Esteva De Antonio, Isabel

    2012-01-01

    Transsexual patients can only be diagnosed and treated at functional gender identity Units with provision of high quality care, development of clinical practice guidelines, and interdisciplinary working groups. The therapeutic process has three mainstays: initial psychological diagnostic evaluation and psychotherapy, endocrinological evaluation and hormone therapy, and sex reassignment surgery. Cross-sex hormone therapy is essential for the anatomical and psychological transition process in duly selected patients. Hormones help optimize real-life sex identity, improve quality of life, and limit psychiatric co-morbidities often associated to lack of treatment. Development of this clinical practice guideline addresses the need for implementing a coordinated action protocol for comprehensive health care for transgender people in the National Health System. PMID:22542505

  8. Analyzing the "CareGap": assessing gaps in adherence to clinical guidelines in adult soft tissue sarcoma.

    Science.gov (United States)

    Waks, Zeev; Goldbraich, Esther; Farkash, Ariel; Torresani, Michele; Bertulli, Rossella; Restifo, Nicola; Locatelli, Paolo; Casali, Paolo; Carmeli, Boaz

    2013-01-01

    Clinical decision support systems (CDSSs) are gaining popularity as tools that assist physicians in optimizing medical care. These systems typically comply with evidence-based medicine and are designed with input from domain experts. Nonetheless, deviations from CDSS recommendations are abundant across a broad spectrum of disorders, raising the question as to why this phenomenon exists. Here, we analyze this gap in adherence to a clinical guidelines-based CDSS by examining the physician treatment decisions for 1329 adult soft tissue sarcoma patients in northern Italy using patient-specific parameters. Dubbing this analysis "CareGap", we find that deviations correlate strongly with certain disease features such as local versus metastatic clinical presentation. We also notice that deviations from the guideline-based CDSS suggestions occur more frequently for patients with shorter survival time. Such observations can direct physicians' attention to distinct patient cohorts that are prone to higher deviation levels from clinical practice guidelines. This illustrates the value of CareGap analysis in assessing quality of care for subsets of patients within a larger pathology. PMID:23542965

  9. Assessment of cardiovascular reactivity by fractal and recurrence quantification analysis of heart rate and pulse transit time.

    Science.gov (United States)

    Naschitz, J E; Rosner, I; Shaviv, N; Khorshidi, I; Sundick, S; Isseroff, H; Fields, M; Priselac, R M; Yeshurun, D; Sabo, E; Itzhak, R

    2003-02-01

    Methods used for the assessment of cardiovascular reactivity are flawed by nonlinear dynamics of the cardiovascular responses to stimuli. In an attempt to address this issue, we utilized a short postural challenge, recorded beat-to-beat heart rate (HR) and pulse transit time (PTT), assessed the data by fractal and recurrence quantification analysis, and processed the obtained variables by multivariate statistics. A 10-min supine phase of the head-up tilt test was followed by recording 600 cardiac cycles on tilt, that is, 5-10 min. Three groups of patients were studied, each including 20 subjects matched for age and gender--healthy subjects, patients with essential hypertension (HT), and patients with chronic fatigue syndrome (CFS). The latter group was studied on account of the well-known dysautonomia of CFS patients, which served as contrast against the cardiovascular reactivity of the healthy population. A total of 52 variables of the HR and PTT were determined in each subject. The multivariate model identified the best predictors for the assessment of reactivity of healthy subjects vs CFS. Based on these predictors, the "Fractal & Recurrence Analysis-based Score" (FRAS) was calculated: FRAS=76.2+0.04*HR-supine-DET -12.9*HR-tilt-R/L -0.31*HR-tilt-s.d. -19.27*PTT-tilt-R/L -9.42*PTT-tilt-WAVE. The median values and IQR of FRAS in the groups were: healthy=-1.85 (IQR 1.89), hypertensives=+0.52 (IQR 5.78), and CFS=-24.2 (5.34) (HT vs healthy subjects: P=0.0036; HT vs CFS: P<0.0001). Since the FRAS differed significantly between the three groups, it appears likely that the FRAS may recognize phenotypes of cardiovascular reactivity. PMID:12574789

  10. Validation of a guideline-based composite outcome assessment tool for asthma control

    Directory of Open Access Journals (Sweden)

    Bendall Kate L

    2007-03-01

    Full Text Available Abstract Background A global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC asthma and well controlled (WC asthma. Methods We used data from 3416 patients randomised and treated in the multi-centre Gaining Optimal Asthma controL (GOAL study. The criteria comprising the asthma control measures were based on Global Initiative for Asthma/National Institutes of Health guidelines. This validation study examined the measurement properties of the asthma control measures using data from run-in, baseline, 12 and 52 weeks. Forced expiratory volume in 1 second (FEV1 and the Asthma Quality of Life Questionnaire (AQLQ were used as the reference criteria in the validation analysis. Results Both measures had good discriminative ability showing significant differences in FEV1 and AQLQ scores between control classification both cross-sectionally and longitudinally (p 1 after 52 weeks than the individual components of each asthma control measure. Both of the reference criteria were independently related to each asthma control measure (p 1 and AQLQ scores at 52 weeks by control classification at 12 weeks (p Conclusion The guideline-based composite asthma control measures of WC asthma and TC asthma have good psychometric properties and are both valid functional indices of disease control in asthma.

  11. Assessing the diagnostic accuracy of the identification of hyperkinetic disorders following the introduction of government guidelines in England

    Directory of Open Access Journals (Sweden)

    Ford Tamsin

    2008-11-01

    Full Text Available Abstract Background Previous studies have suggested that both underdiagnosis and overdiagnosis routinely occur in ADHD and hyperkinesis (hyperkinetic disorders. England has introduced governmental guidelines for these disorders' detection and treatment, but there has been no study on clinical diagnostic accuracy under such a regime. Methods All open cases in three Child and Adolescent Mental Health Services (CAMHS in the South East of England were assessed for accuracy in the detection of hyperkinetic disorders, using a two-stage process employing the Strengths and Difficulties Questionnaire (SDQ for screening, with the cut-off between "unlikely" and "possible" as the threshold for identification, and the Development And Well-Being Assessment (DAWBA as a valid and reliable standard. Results 502 cases were collected. Their mean age 11 years (std dev 3 y; 59% were clinically diagnosed as having a hyperkinetic disorder including ADHD. Clinicians had missed two diagnoses of hyperkinesis and six of ADHD. The only 'false positive' case was one that had become asymptomatic on appropriate treatment. Conclusion The identification of children with hyperkinetic disorders by three ordinary English CAMHS teams appears now to be generally consistent with that of a validated, standardised assessment. It seems likely that this reflects the impact of Governmental guidelines, which could therefore be an appropriate tool to ensure consistent accurate diagnosis internationally.

  12. Developing Guidelines on the Assessment and Treatment of Delirium in Older Adults at the End of Life

    OpenAIRE

    Brajtman, Susan; Wright, David; Hogan, David B.; Allard, Pierre; Bruto, Venera; Burne, Deborah; Gage, Laura; Pierre R Gagnon; Sadowski, Cheryl A; Helsdingen, Sherri; Wilson, Kimberley

    2011-01-01

    Background and Purpose Delirium at the end of life is common and can have serious consequences on an older person’s quality of life and death. In spite of the importance of detecting, diagnosing, and managing delirium at the end of life, comprehensive clinical practice guidelines (CPG) are lacking. Our objective was to develop CPG for the assessment and treatment of delirium that would be applicable to seniors receiving end-of-life care in diverse settings. Methods Using as a starting point t...

  13. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis.

    Science.gov (United States)

    Eichenfield, Lawrence F; Tom, Wynnis L; Chamlin, Sarah L; Feldman, Steven R; Hanifin, Jon M; Simpson, Eric L; Berger, Timothy G; Bergman, James N; Cohen, David E; Cooper, Kevin D; Cordoro, Kelly M; Davis, Dawn M; Krol, Alfons; Margolis, David J; Paller, Amy S; Schwarzenberger, Kathryn; Silverman, Robert A; Williams, Hywel C; Elmets, Craig A; Block, Julie; Harrod, Christopher G; Smith Begolka, Wendy; Sidbury, Robert

    2014-02-01

    Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in the management and care of AD, providing updated and expanded recommendations based on the available evidence. In this first of 4 sections, methods for the diagnosis and monitoring of disease, outcomes measures for assessment, and common clinical associations that affect patients with AD are discussed. Known risk factors for the development of disease are also reviewed. PMID:24290431

  14. Assessment of methods for quantification of exhaust emissions from marine dieselengines

    OpenAIRE

    Tveitaskog, Kari Anne

    2010-01-01

    The focus on exhaust emissions has increased the last decades. In the coming years emission restrictions on nitrogen oxides (NOx) will be intensified while restrictions on PM are still pending consensus. With this, it becomes increasingly important that the emission measurements achieved during engine certification reflects the emissions formed during real engine operation. This study presents results of an assessment of measurement procedures for quantifying NOx and PM emissions from marine ...

  15. The external water footprint of the Netherlands: quantification and impact assessment

    OpenAIRE

    Oel, van, P.R.; M. M. Mekonnen; A. Y. Hoekstra

    2008-01-01

    This study quantifies the external water footprint of the Netherlands by partner country and import product and assesses the impact of this footprint by contrasting the geographically explicit water footprint with water scarcity in the different parts of the world. Hotspots are identified as the places where the external water footprint of Dutch consumers is significant on the one hand and where water scarcity is serious on the other hand. The study shows that Dutch consumption implies the us...

  16. Clinical risk of stigma and discrimination of mental illnesses: Need for objective assessment and quantification

    OpenAIRE

    Shrivastava, Amresh; Bureau, Yves; Rewari, Nitika; Johnston, Megan

    2013-01-01

    Stigma and discrimination continue to be a reality in the lives of people suffering from mental illness, particularly schizophrenia, and prove to be one of the greatest barriers to regaining a normal lifestyle and health. Research advances have defined stigma and assessed its implications and have even examined intervention strategies for dealing with stigma. We are of the opinion that stigma is a potential clinical risk factor. It delays treatment seeking, worsens course and outcome, reduces...

  17. A comparative assessment of tools for ecosystem services quantification and valuation

    Science.gov (United States)

    Bagstad, Kenneth J.; Semmens, Darius; Waage, Sissel; Winthrop, Robert

    2013-01-01

    To enter widespread use, ecosystem service assessments need to be quantifiable, replicable, credible, flexible, and affordable. With recent growth in the field of ecosystem services, a variety of decision-support tools has emerged to support more systematic ecosystem services assessment. Despite the growing complexity of the tool landscape, thorough reviews of tools for identifying, assessing, modeling and in some cases monetarily valuing ecosystem services have generally been lacking. In this study, we describe 17 ecosystem services tools and rate their performance against eight evaluative criteria that gauge their readiness for widespread application in public- and private-sector decision making. We describe each of the tools′ intended uses, services modeled, analytical approaches, data requirements, and outputs, as well time requirements to run seven tools in a first comparative concurrent application of multiple tools to a common location – the San Pedro River watershed in southeast Arizona, USA, and northern Sonora, Mexico. Based on this work, we offer conclusions about these tools′ current ‘readiness’ for widespread application within both public- and private-sector decision making processes. Finally, we describe potential pathways forward to reduce the resource requirements for running ecosystem services models, which are essential to facilitate their more widespread use in environmental decision making.

  18. 99mTc-GSA dynamic SPECT for regional hepatic functional reserve estimation. Assessment of quantification

    International Nuclear Information System (INIS)

    The aim of this study is the assessment of the physiological implication of estimated parameters and the clinical value of this analyzing method for hepatic functional reserve estimation. After venous injection of 185 MBq of GSA, fifteen sequential sets of SPECT data were acquired for 15 minutes. First 5 sets SPECT images were analyzed by Patlak plot and hepatic GSA clearance was obtained in each matrix. The sum of hepatic GSA clearance in each matrix (total hepatic GSA clearance) was calculated as an index of whole liver functional reserve. Total hepatic GSA clearance was compared with receptor index or effective blood flow (EHBF) of whole liver which were analyzed by Direct Integral Linear Least Square Regression (DILS) method for the assessment of the physiological implications of hepatic GSA clearance. The clinical value of total hepatic GSA clearance was assessed in comparisons with the conventional hepatic function test. A very good correlations were observed between total hepatic GSA clearance and receptor index, whereas the correlations between total hepatic GSA clearance and EHBF were not significant. Significant correlations were also observed between total hepatic GSA clearance and the conventional hepatic function tests, such as choline esterase, albumin, hepaplastin test, ICG R15. (K.H.)

  19. Probabilistic safety assessment of WWER440 reactors prediction, quantification and management of the risk

    CERN Document Server

    Kovacs, Zoltan

    2014-01-01

    The aim of this book is to summarize probabilistic safety assessment (PSA) of nuclear power plants with WWER440 reactors and  demonstrate that the plants are safe enough for producing energy even in light of the Fukushima accident. The book examines level 1 and 2 full power, low power and shutdown PSA, and summarizes the author's experience gained during the last 35 years in this area. It provides useful examples taken from PSA training courses the author has lectured and organized by the International Atomic Energy Agency. Such training courses were organised in Argonne National Laboratory (

  20. The quantification of environmental indicators for sustainability assessment of future electricity supply options

    International Nuclear Information System (INIS)

    Within the project NEEDS (New Energy Externalities Development for Sustainability) a range of criteria and indicators were defined according to the widely recognised 'three pillar' interpretation of sustainable development in order to assess future electricity generating technologies including their associated fuel cycles. The basic characteristics of the 26 technologies were defined as being appropriate in 2050 according to 'realistic/optimistic' development scenarios. The potential environmental impacts of each technology were assessed by initially determining the various criteria necessary to describe the range of significant impact areas. These criteria were then expressed and measured by one or more quantifiable indicators which were calculated using Life Cycle Inventories established earlier in the project. This report contributed to Research Stream RS2b of the project by quantifying and comparing the results of these indicators for each of the four countries used in the assessment: France, Germany, Switzerland and Italy. The environmental assessment showed that the nuclear technologies cause relatively very low impacts according to most of the indicators. The Generation IV, European Fast Reactor, has significant advantages over the European Pressurised Reactor but the availabilities of the two reactors will be quite different. Whereas the first examples of the EPR are already under construction, the design finalisation of the EFR is not yet complete meaning that the first plant is not expected to be constructed before 2040. An overarching and clear distinction between the fossil fueled technologies was less possible and the application of carbon capture and storage, whilst showing large reductions in greenhouse gas emissions, was shown to be counteracted in a number of other indicators. The integration of solid fuel gasification prior to combustion also showed both benefits and disadvantages. For most indicators, the natural gas combined cycle options

  1. Valvular heart disease: assessment of valve morphology and quantification using MR

    International Nuclear Information System (INIS)

    For clinical evaluation and decision-making in patients with valvular heart disease, the diagnostic armamentarium expands steadily. This evolution makes it difficult to choose the most appropriate approach for a specific valvular lesion. It may also reflect our uncertainty of what are the findings that best predict clinical outcome of patients, e. g. after surgery. Accordingly, for each type of valvular lesion, some pathophysiological considerations are stated in order to derive the most important measures that would allow optimal guidance of patients. Based on these considerations the value of an MR study is discussed for each valvular lesion. Newest advances in MR technology allow for highly accurate measurements of regurgitant volumes and hence, MR may be the method of choice for a quantitative evaluation of regurgitant valves. For assessment of stenosis severity, measurement of transvalvular pressure gradient is an appropriate measure and MR may not confer benefits over echocardiography, provided the ultrasound window is adequate (and stroke volume is in the normal range). With respect to surgical treatment, valvular morphology is of pivotal importance, particularly for the mitral valve, and echocardiography still appears to be the first line method. Little data relate lesion severity and/or morphology to clinical outcome. Conversely, the extent of cardiac adaptation to pressure- and/or volume-overload, i. e. ventricular remodeling, is a strong predictor of outcome, and is therefore most important for final judgement of the patient. For assessment of left and right ventricular remodeling, echocardiography typically provides all the necessary information. However, in special cases with discrepant findings, with inadequate ultrasound window, or in the preoperative work-up, MR may provide important information regarding cardiac adaptation to valvular lesion. (orig.)

  2. Evaluation of Chemical Warfare Agent Percutaneous Vapor Toxicity: Derivation of Toxicity Guidelines for Assessing Chemical Protective Ensembles.

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.P.

    2003-07-24

    Percutaneous vapor toxicity guidelines are provided for assessment and selection of chemical protective ensembles (CPEs) to be used by civilian and military first responders operating in a chemical warfare agent vapor environment. The agents evaluated include the G-series and VX nerve agents, the vesicant sulfur mustard (agent HD) and, to a lesser extent, the vesicant Lewisite (agent L). The focus of this evaluation is percutaneous vapor permeation of CPEs and the resulting skin absorption, as inhalation and ocular exposures are assumed to be largely eliminated through use of SCBA and full-face protective masks. Selection of appropriately protective CPE designs and materials incorporates a variety of test parameters to ensure operability, practicality, and adequacy. One aspect of adequacy assessment should be based on systems tests, which focus on effective protection of the most vulnerable body regions (e.g., the groin area), as identified in this analysis. The toxicity range of agent-specific cumulative exposures (Cts) derived in this analysis can be used as decision guidelines for CPE acceptance, in conjunction with weighting consideration towards more susceptible body regions. This toxicity range is bounded by the percutaneous vapor estimated minimal effect (EME{sub pv}) Ct (as the lower end) and the 1% population threshold effect (ECt{sub 01}) estimate. Assumptions of exposure duration used in CPE certification should consider that each agent-specific percutaneous vapor cumulative exposure Ct for a given endpoint is a constant for exposure durations between 30 min and 2 hours.

  3. General guidelines for safe and expeditious international transport of samples subjected to biological dosimetry assessment

    International Nuclear Information System (INIS)

    It has been observed that victims of accidental overexposures show better chance of survival if they receive medical treatment early. The increased risk of scenarios involving mass casualties has stimulated the scientific community to develop tools that would help the medical doctors to treat victims. The biological dosimetry has become a routine test to estimate the dose, supplementing physical and clinical dosimetry. In case of radiation emergencies, in order to provide timely and effectively biological dosimetry assistance it is essential to guarantee an adequate transport of blood samples in principal, for providing support to countries that do not have bio-dosimetry laboratories. The objective of the present paper is to provide general guidelines, summarised in 10 points, for timely and proper receiving and sending of blood samples under National and International regulations, for safe and expeditious international transport. These guidelines cover the classification, packaging, marking, labelling, refrigeration and documentation requirements for the international shipping of blood samples and pellets, to provide assistance missions with a tool that would contribute with the preparedness for an effective bio-dosimetric response in cases of radiological or nuclear emergencies. (authors)

  4. Guidelines for youth sports clubs to develop, implement, and assess health promotion within its activities.

    Science.gov (United States)

    Kokko, Sami

    2014-05-01

    The settings approach to health promotion is a world-known concept concerning settings like city, hospital, school, and workplace. The concept has also been used in some regionally specific settings, such as island, prison, or university. However, there are still many, often noninstitutional, settings that have a lot of potential but have not yet been recognized. One of the newcomers is the youth sports club, which has the potential to reach a lot of children and adolescents and is effective, via its casual educational nature based on voluntary participation. According to research, health is an important aim for most youth sports clubs, but it has not been converted into practical actions. Indeed, the clubs often recognize the importance of healthy lifestyles, but there is a lack of understanding of what to do to reinforce it within one's activities. That is why, on the basis of the results of the Health Promoting Sports Club survey in Finland, guidelines for clubs to enhance health promotion as a part of their activities were created. The aim of this article is to present the guidelines, theirs rationale, and practical examples. PMID:24357861

  5. Patient safety in external beam radiotherapy – Guidelines on risk assessment and analysis of adverse error-events and near misses: Introducing the ACCIRAD project

    International Nuclear Information System (INIS)

    In 2011 the European Commission launched a tender to develop guidelines for risk analysis of accidental and unintended exposures in external beam radiotherapy. This tender was awarded to a consortium of 6 institutions, including the ESTRO, in late 2011. The project, denominated “ACCIRAD”, recently finished the data collection phase. Data were collected by surveys administered in 38 European countries. Results indicate non-uniform implementation of event registration and classification, as well as incomplete or zero implementation of risk assessment and events analysis. Based on the survey results and analysis thereof, project leaders are currently drafting proposed guidelines entitled “Guidelines for patient safety in external beam radiotherapy – Guidelines on risk assessment and analysis of adverse-error events and near misses”. The present article describes the aims and current status of the project, including results of the surveys

  6. Methodological guidelines

    International Nuclear Information System (INIS)

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs

  7. Methodological guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-04-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs.

  8. Quantification of cerivastatin toxicity supports organismal performance assays as an effective tool during pharmaceutical safety assessment.

    Science.gov (United States)

    Gaukler, Shannon M; Ruff, James S; Galland, Tessa; Underwood, Tristan K; Kandaris, Kirstie A; Liu, Nicole M; Morrison, Linda C; Veranth, John M; Potts, Wayne K

    2016-06-01

    A major problem in pharmaceutical development is that adverse effects remain undetected during preclinical and clinical trials, but are later revealed after market release when prescribed to many patients. We have developed a fitness assay known as the organismal performance assay (OPA), which evaluates individual performance by utilizing outbred wild mice (Mus musculus) that are assigned to an exposed or control group, which compete against each other for resources within semi-natural enclosures. Performance measurements included reproductive success, survival, and male competitive ability. Our aim was to utilize cerivastatin (Baycol(®), Bayer), a pharmaceutical with known adverse effects, as a positive control to assess OPAs as a potential tool for evaluating the safety of compounds during preclinical trials. Mice were exposed to cerivastatin (~4.5 mg/kg/day) into early adulthood. Exposure ceased and animals were released into semi-natural enclosures. Within enclosures, cerivastatin-exposed females had 25% fewer offspring and cerivastatin-exposed males had 10% less body mass, occupied 63% fewer territories, sired 41% fewer offspring, and experienced a threefold increase in mortality when compared to controls. OPAs detected several cerivastatin-induced adverse effects indicating that fitness assays, commonly used in ecology and evolutionary biology, could be useful as an additional tool in safety testing during pharmaceutical development. PMID:27247619

  9. Quantification of radionuclide transfer in terrestrial and freshwater environments for radiological assessments

    International Nuclear Information System (INIS)

    For more than thirty years, the IAEA has published a set of documents aimed at the limitation of the radiation exposure of the population from various nuclear activities. In particular, in 1994 the IAEA published Technical Reports Series No. 364, Handbook of Parameter Values for the Prediction of Radionuclide Transfer in Temperate Environments. Over the years, it has proved to be a valuable reference for radioecologists, modellers and authorities in Member States, and has been quoted in numerous impact assessments. Technical Reports Series No. 364 was based on a review of available data up to the end of 1992. However, a number of high quality critical reviews have been produced in recent years for some of the transfer parameter values which merit consideration. Thus, it was assumed that there is sufficient new information available to warrant reconsideration of a significant proportion of the values given in Technical Reports Series No. 364 and to initiate an updating of Technical Reports Series No. 364 in the framework of the IAEA EMRAS (Environmental Modelling for RAdiation Safety) project. It is expected that the revision of Technical Reports Series No. 364 will initiate further updating of related IAEA publications, and international and national radiological models. The present IAEA-TECDOC is intended to be a support to the update of Technical Reports Series No. 364, overcoming the limitations of the former, and comprises both revised transfer parameter values, as well as missing data, key transfer processes, concepts and models that were found to be important for radiation safety

  10. Guidelines and workbook for assessment of organization and administration of utilities seeking operating license for a nuclear power plant. Guidelines for utility organization and administration plan. Volume 1

    International Nuclear Information System (INIS)

    The Guidelines are intended to provide guidance to the user in preparing a written plan for a proposed nuclear organization and administration. The Guidelines allow for individual approaches to organizational structures to account for differences in plant size, number of operating units, number of plant sites, and the individual utility approach to providing technical support. These unique approaches, however, should meet the criteria of a reasoned, fully developed, and logically consistent focus on the user's organization in terms of organization of work, policies and procedures, staffing, and external relationships

  11. Quantification of tsunami hazard on Canada's Pacific Coast; implications for risk assessment

    Science.gov (United States)

    Evans, Stephen G.; Delaney, Keith B.

    2015-04-01

    Our assessment of tsunami hazard on Canada's Pacific Coast (i.e., the coast of British Columbia) begins with a review of the 1964 tsunami generated by The Great Alaska Earthquake (M9.2) that resulted in significant damage to coastal communities and infrastructure. In particular, the tsunami waves swept up inlets on the west coast of Vancouver Island and damaged several communities; Port Alberni suffered upwards of 5M worth of damage. At Port Alberni, the maximum tsunami wave height was estimated at 8.2 m above mean sea level and was recorded on the stream gauge on the Somass River located at about 7 m a.s.l, 6 km upstream from its mouth. The highest wave (9.75 m above tidal datum) was reported from Shields Bay, Graham Island, Queen Charlotte Islands (Haida Gwaii). In addition, the 1964 tsunami was recorded on tide gauges at a number of locations on the BC coast. The 1964 signal and the magnitude and frequency of traces of other historical Pacific tsunamis (both far-field and local) are analysed in the Tofino tide gauge records and compared to tsunami traces in other tide gauges in the Pacific Basin (e.g., Miyako, Japan). Together with a review of the geological evidence for tsunami occurrence along Vancouver Island's west coast, we use this tide gauge data to develop a quantitative framework for tsunami hazard on Canada's Pacific coast. In larger time scales, tsunamis are a major component of the hazard from Cascadia megathrust events. From sedimentological evidence and seismological considerations, the recurrence interval of megathrust events on the Cascadia Subduction Zone has been estimated by others at roughly 500 years. We assume that the hazard associated with a high-magnitude destructive tsunami thus has an annual frequency of roughly 1/500. Compared to other major natural hazards in western Canada this represents a very high annual probability of potentially destructive hazard that, in some coastal communities, translates into high levels of local risk

  12. School-Based Mental Health Professionals' Bullying Assessment Practices: A Call for Evidence-Based Bullying Assessment Guidelines

    Science.gov (United States)

    Blake, Jamilia; Banks, Courtney S.; Patience, Brenda A.; Lund, Emily M.

    2014-01-01

    A sample of 483 school-based mental health professionals completed a survey about the training they have received related to conducting bullying assessments in schools, competence in conducting an assessment of bullying, and the bullying assessment methods they used. Results indicate that school counselors were usually informed about incidents of…

  13. Deliverable 4.3 Decision support guideline based on LCA and cost/efficiency assessment

    OpenAIRE

    Larsen, Henrik Fred; Hansen, Peter Augusto; Boyer-Souchet, Florence

    2010-01-01

    The environmental sustainability assessments described in this report is based on life cycle assessments (LCA) of selected waste water treatment technology (WWTT) cases included in NEPTUNE. The basic approach in these assessments (avoided against induced impacts) is described in Deliverable 4.1 (Larsen et al. 2007) and other methodological issues (e.g. normalization and weighting) in Deliverable 4.2 (Larsen et al. 2009). The basic approach is illustrated in a simplified way for the case ozona...

  14. Rapid Quantification of Viable Campylobacter Bacteria on Chicken Carcasses, Using Real-Time PCR and Propidium Monoazide Treatment, as a Tool for Quantitative Risk Assessment

    DEFF Research Database (Denmark)

    Josefsen, Mathilde Hartmann; Löfström, Charlotta; Hansen, Tina Beck;

    2010-01-01

    correlated with Ct-values (R(2) = 0.993), with a quantification range from 1x10(2)-1x10(7) CFU/ml. The correlation between the Campylobacter counts obtained by PMA-PCR and culture on naturally contaminated chickens was high (R(2) = 0.844). The amplification efficiency of the Q-PCR method was not affected by....... The proposed method does not detect DNA from dead Campylobacter, but recognises the infectious potential of the VBNC state, and is thereby able to assess the effect of control strategies, and provide trustworthy data for risk assessment....

  15. Rapid quantification of viable Campylobacter on chicken carcasses by real-time PCR and propidium monoazide as a tool for quantitative risk assessment

    DEFF Research Database (Denmark)

    Josefsen, Mathilde Hartmann; Löfström, Charlotta; Hansen, Tina Beck;

    2010-01-01

    correlated with Ct-values (R2 = 0.993), with a quantification range from 1×1021×107 CFU/ml. The correlation between the Campylobacter counts obtained by PMA-PCR and culture on naturally contaminated chickens was high (R2 = 0.844). The amplification efficiency of the Q-PCR method was not affected by chicken...... proposed method does not detect DNA from dead Campylobacter, but recognises the infectious potential of the VBNC state, and is thereby able to assess the effect of control strategies, and provide trustworthy data for risk assessment....

  16. International guidelines for the in vivo assessment of skin properties in non-clinical settings

    DEFF Research Database (Denmark)

    du Plessis, Johan; Stefaniak, Aleksandr; Eloff, Fritz;

    2013-01-01

    There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, repre...

  17. EPA`s program for risk assessment guidelines: Cancer classification issues

    Energy Technology Data Exchange (ETDEWEB)

    Wiltse, J. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    Issues presented are related to classification of weight of evidence in cancer risk assessments. The focus in this paper is on lines of evidence used in constructing a conclusion about potential human carcinogenicity. The paper also discusses issues that are mistakenly addressed as classification issues but are really part of the risk assessment process. 2 figs.

  18. Consensus clinical guidelines for the assessment of cognitive and behavioural problems in Tuberous Sclerosis.

    Science.gov (United States)

    de Vries, Petrus; Humphrey, Ayla; McCartney, Deborah; Prather, Penny; Bolton, Patrick; Hunt, Ann

    2005-07-01

    Tuberous Sclerosis (TSC) is a genetic disorder characterised by abnormal growths in a wide range of organs. In the brain, abnormalities of differentiation, proliferation and migration can produce a range of neuropsychiatric features such as mental retardation, autism and ADHD. Although these manifestations are not diagnostic of the disorder, cognitive and behavioural features are often of greatest concern to families yet limited clinical assessment and interventions are currently offered. A consensus panel at a TSC Brain/Behaviour workshop recommended that the cognitive and behavioural profiles of individuals with TSC should be assessed at regular intervals in a planned fashion in accordance with the difficulties associated with the disorder. Evaluations should include the use of standardised neuropsychological and behavioural tools as appropriate to the age and developmental level of the individual assessed. These cognitive and behavioural profiles should be incorporated in the overall formulation of the needs of the person with TSC to plan educational, social and clinical management strategies. Assessments should be documented so that individual longitudinal progress can be monitored. The paper outlines the problems associated with TSC, the purpose of recommended assessments, developmentally appropriate stages for assessment, and identifies specific areas that should be targeted for assessment. PMID:15981129

  19. Review of achievements of the OECD Working Party on Manufactured Nanomaterials' Testing and Assessment Programme. From exploratory testing to test guidelines.

    Science.gov (United States)

    Rasmussen, Kirsten; González, Mar; Kearns, Peter; Sintes, Juan Riego; Rossi, François; Sayre, Phil

    2016-02-01

    This paper charts the almost ten years of history of OECD's work on nanosafety, during which the programme of the OECD on the Testing and Assessment of Manufactured Nanomaterials covered the testing of eleven nanomaterials for about 59 end-points addressing physical-chemical properties, mammalian and environmental toxicity, environmental fate and material safety. An overview of the materials tested, the test methods applied and the discussions regarding the applicability of the OECD test guidelines, which are recognised methods for regulatory testing of chemicals, are given. The results indicate that many existing OECD test guidelines are suitable for nanomaterials and consequently, hazard data collected using such guidelines will fall under OECD's system of Mutual Acceptance of Data (MAD) which is a legally binding instrument to facilitate the international acceptance of information for the regulatory safety assessment of chemicals. At the same time, some OECD test guidelines and guidance documents need to be adapted to address nanomaterials while new test guidelines and guidance documents may be needed to address endpoints that are more relevant to nanomaterials. This paper presents examples of areas where test guidelines or guidance for nanomaterials are under development. PMID:26603783

  20. APPLICATION OF SEDIMENT QUALITY GUIDELINES IN THE ASSESSMENT OF MANGROVE SURFACE SEDIMENT IN MENGKABONG LAGOON, SABAH, MALAYSIA

    OpenAIRE

    S. M. Praveena, M. Radojevic, M. H. Abdullah, A. Z. Aris

    2008-01-01

    There have been numerous sediment quality guidelines developed to monitor the sediments. Sediment quality guidelines are very useful to screen sediment contamination by comparing sediment contaminant concentration with the corresponding quality guideline, provide useful tools for screening sediment chemical data to identify pollutants of concern and prioritise problem sites and relatively good predictors of contaminations. However, these guidelines are chemical specific and do not include bio...

  1. Physiotherapy in hip and knee osteoarthritis: development of a practice guideline concerning initial assessment, treatment and evaluation.

    NARCIS (Netherlands)

    Peter, W.F.H.; Jansen, M.J.; Hurkmans, E.J.; Bloo, H.; Dekker-Bakker, L.M.M.C.J.; Dilling, R.G.; Hilberdink, W.K.H.A.; Kersten-Smit, C.; Rooij, M. de; Veenhof, C.; Vermeulen, H.M.; Vos, R.J. de; Schoones, J.W.; Vliet Vlieland, T.P.M.

    2011-01-01

    BACKGROUND: An update of a Dutch physiotherapy practice guideline in Hip and Knee Osteoarthritis (HKOA) was made, based on current evidence and best practice. METHODS: A guideline steering committee, comprising 10 expert physiotherapists, selected topics concerning the guideline chapters: initial as

  2. Identification of the most influential factors in the Norwegian guidelines for risk assessment of dispersion of contaminants from sediments.

    Science.gov (United States)

    Saloranta, Tuomo M; Ruus, Anders; Borgå, Katrine

    2011-10-01

    The Norwegian guidelines for risk assessment of contaminated sediments are used to identify areas of concern where remediation may be needed to meet the governmental long-term goal of clean fjords and harbors along the Norwegian coastline. By a thorough sensitivity analysis, this study identifies the most influential factors and parameters for the Tier 2A model in this risk guideline, which are used to estimate fluxes of contaminants from sediments due to diffusion and bioturbation (F(diff)), resuspension caused by ship traffic (F(skipnorm)), and uptake and predation of benthic biota (F(org)). The sensitivity analysis is run for 36 different scenarios combining 3 different sizes of contaminated area, 3 harbor types, and 3 persistent organic pollutants, namely lindane (γ-hexachlorocyclohexane), benzo[a]pyrene, and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), as well as the metal mercury (Hg). The most influential parameters vary from scenario to scenario, but generally 5 parameters appear to be particularly influential for the fluxes and transport estimated by the Tier 2A model: flux of organic carbon to sediment (OC(sed)), factor for increased diffusion due to bioturbation (a), sediment-water partitioning coefficient (K(d)), benthic biota-water bioconcentration factor (BCF(fisk)), and mass of resuspended fine sediment during arrival or departure of a ship (m(sed)). We also quantify which of the 3 fluxes (F(diff), F(skipnorm), and F(org)) dominate in the different scenarios. Our sensitivity analysis results can be used by authorities, problem owners, consultants, and environmental managers involved in contaminated sediment management to gain insight on the key processes and parameters and to focus their site-specific or laboratory-based measurement efforts on the key parameters and thus increase efficiency and reliability in the contaminated sediment risk assessment. PMID:21384542

  3. Guidelines for the environmental impact assessment in procedure for mining projects

    Energy Technology Data Exchange (ETDEWEB)

    Salminen, R.; Heikkinen, P.; Nikkarinen, M.; Parkkinen, J.; Sipilae, P.; Suomela, P.; Wennerstroem, M.

    2000-01-01

    The procedure for environmental impact assessment (EIA) in connection with mining covers extraction, preparation and processing of metallic minerals or other extractable minerals when the total amount of ore to be extracted is at least 550 000 tonnes per year or when the surface area of the open-cast mine exceeds 25 hectares. In addition, the Ministry of the Environment can decide that the assessment procedure shall be applied to an individual project (The EIA Act paragraph 1, section 4.) The EIA procedure is two-stage. The first stage comprises drawing up of an assessment programme. The second stage includes collecting assessment reports on the basis of which an assessment of the environmental impact will be made. The authority concerned shall then disseminate information on the project and arrange hearing of the parties. Hearing is followed by submission of an executive summary of the assessment programme and the environmental impact assessment, which together with the environmental impact statement will be used by the licensing authority when taking decision on the matter. The environmental impact assessment procedure in connection with mining will coincide either with the application for mining concession or the submission of the environmental impact statement to the Safety Technology Authority together with a general plan. The aim of the environmental impact assessment is to study what indirect and direct, both positive and negative, effects the project will have on the surrounding nature, man, society and industry. A further aim is to present a proposal for actions in order to prevent and limit the detrimental effects of the project on the environment as well as to present a proposal for a follow-up programme. The dialogue between the operator and the contact authority is of great importance during the entire process of the environmental impact assessment. It is in the interest of all parties that the environmental impact assessment will be made with care. In

  4. Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines

    Directory of Open Access Journals (Sweden)

    C. Dirk Keene

    2016-06-01

    Full Text Available Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD, have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy of drugs for treating AD patients. Therefore, development of more translationally relevant AD mouse models remains a critical unmet need in the field. A concept not previously implemented in AD preclinical drug testing is the use of mouse lines that have been validated for neuropathological features of human AD. Current thinking suggests that amyloid plaque and neurofibrillary tangle deposition is an essential component for accurate modeling of AD. Therefore, the AD translational paradigm would require pathologic Aβ and tau deposition, a disease-relevant distribution of plaques and tangles, and a pattern of disease progression of Aβ and tau isoforms similar to the neuropathological features found in the brains of AD patients. Additional parameters useful to evaluate parallels between AD and animal models would include 1 cerebrospinal fluid (CSF AD biomarker changes with reduced Aβ and increased phospho-tau/tau; 2 structural and functional neuroimaging patterns including MRI hippocampal atrophy, fluorodeoxyglucose (FDG, and amyloid/tau PET alterations in activity and/or patterns of pathologic peptide deposition and distribution; and 3 cognitive impairment with emphasis on spatial learning and memory to distinguish presymptomatic and symptomatic mice at specific ages. A validated AD mouse model for drug testing would likely show tau-related neurofibrillary degeneration following Aβ deposition and demonstrate changes in pathology, CSF analysis, and neuroimaging that mirror human AD. Development of the ideal model would revolutionize the ability to establish the translational value of AD mouse models and serve as a platform for discussions about national phenotyping guidelines

  5. Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines.

    Science.gov (United States)

    Keene, C Dirk; Darvas, Martin; Kraemer, Brian; Liggitt, Denny; Sigurdson, Christina; Ladiges, Warren

    2016-01-01

    Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD), have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy of drugs for treating AD patients. Therefore, development of more translationally relevant AD mouse models remains a critical unmet need in the field. A concept not previously implemented in AD preclinical drug testing is the use of mouse lines that have been validated for neuropathological features of human AD. Current thinking suggests that amyloid plaque and neurofibrillary tangle deposition is an essential component for accurate modeling of AD. Therefore, the AD translational paradigm would require pathologic Aβ and tau deposition, a disease-relevant distribution of plaques and tangles, and a pattern of disease progression of Aβ and tau isoforms similar to the neuropathological features found in the brains of AD patients. Additional parameters useful to evaluate parallels between AD and animal models would include 1) cerebrospinal fluid (CSF) AD biomarker changes with reduced Aβ and increased phospho-tau/tau; 2) structural and functional neuroimaging patterns including MRI hippocampal atrophy, fluorodeoxyglucose (FDG), and amyloid/tau PET alterations in activity and/or patterns of pathologic peptide deposition and distribution; and 3) cognitive impairment with emphasis on spatial learning and memory to distinguish presymptomatic and symptomatic mice at specific ages. A validated AD mouse model for drug testing would likely show tau-related neurofibrillary degeneration following Aβ deposition and demonstrate changes in pathology, CSF analysis, and neuroimaging that mirror human AD. Development of the ideal model would revolutionize the ability to establish the translational value of AD mouse models and serve as a platform for discussions about national phenotyping guidelines and standards

  6. Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis

    Energy Technology Data Exchange (ETDEWEB)

    Kukuk, Guido M.; Block, Wolfgang; Willinek, Winfried A.; Schild, Hans H.; Traeber, Frank [University of Bonn, Department of Radiology, Bonn (Germany); Hittatiya, Kanishka; Fischer, Hans-Peter [University of Bonn, Department of Pathology, Bonn (Germany); Sprinkart, Alois M. [University of Bonn, Department of Radiology, Bonn (Germany); Ruhr-University, Institute of Medical Engineering, Bochum (Germany); Eggers, Holger [Philips Research Europe, Hamburg (Germany); Gieseke, Juergen [University of Bonn, Department of Radiology, Bonn (Germany); Philips Healthcare, Best (Netherlands); Moeller, Philipp; Spengler, Ulrich; Trebicka, Jonel [University of Bonn, Department of Internal Medicine I, Bonn (Germany)

    2015-10-15

    To compare systematically quantitative MRI, MR spectroscopy (MRS), and different histological methods for liver fat quantification in order to identify possible incongruities. Fifty-nine consecutive patients with liver disorders were examined on a 3 T MRI system. Quantitative MRI was performed using a dual- and a six-echo variant of the modified Dixon (mDixon) sequence, calculating proton density fat fraction (PDFF) maps, in addition to single-voxel MRS. Histological fat quantification included estimation of the percentage of hepatocytes containing fat vesicles as well as semi-automatic quantification (qHisto) using tissue quantification software. In 33 of 59 patients, the hepatic fat fraction was >5 % as determined by MRS (maximum 45 %, mean 17 %). Dual-echo mDixon yielded systematically lower PDFF values than six-echo mDixon (mean difference 1.0 %; P < 0.001). Six-echo mDixon correlated excellently with MRS, qHisto, and the estimated percentage of hepatocytes containing fat vesicles (R = 0.984, 0.967, 0.941, respectively, all P < 0.001). Mean values obtained by the estimated percentage of hepatocytes containing fat were higher by a factor of 2.5 in comparison to qHisto. Six-echo mDixon and MRS showed the best agreement with values obtained by qHisto. Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results and are therefore most appropriate for reliable quantification of liver fat. (orig.)

  7. Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis

    International Nuclear Information System (INIS)

    To compare systematically quantitative MRI, MR spectroscopy (MRS), and different histological methods for liver fat quantification in order to identify possible incongruities. Fifty-nine consecutive patients with liver disorders were examined on a 3 T MRI system. Quantitative MRI was performed using a dual- and a six-echo variant of the modified Dixon (mDixon) sequence, calculating proton density fat fraction (PDFF) maps, in addition to single-voxel MRS. Histological fat quantification included estimation of the percentage of hepatocytes containing fat vesicles as well as semi-automatic quantification (qHisto) using tissue quantification software. In 33 of 59 patients, the hepatic fat fraction was >5 % as determined by MRS (maximum 45 %, mean 17 %). Dual-echo mDixon yielded systematically lower PDFF values than six-echo mDixon (mean difference 1.0 %; P < 0.001). Six-echo mDixon correlated excellently with MRS, qHisto, and the estimated percentage of hepatocytes containing fat vesicles (R = 0.984, 0.967, 0.941, respectively, all P < 0.001). Mean values obtained by the estimated percentage of hepatocytes containing fat were higher by a factor of 2.5 in comparison to qHisto. Six-echo mDixon and MRS showed the best agreement with values obtained by qHisto. Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results and are therefore most appropriate for reliable quantification of liver fat. (orig.)

  8. The Role of Measurement Quality on Practical Guidelines for Assessing Measurement and Structural Invariance

    Science.gov (United States)

    Kang, Yoonjeong; McNeish, Daniel M.; Hancock, Gregory R.

    2016-01-01

    Although differences in goodness-of-fit indices (?GOFs) have been advocated for assessing measurement invariance, studies that advanced recommended differential cutoffs for adjudicating invariance actually utilized a very limited range of values representing the quality of indicator variables (i.e., magnitude of loadings). Because quality of…

  9. Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test.

    Science.gov (United States)

    Rodriguez-Miguelez, Paula; Seigler, Nichole; Harris, Ryan A

    2016-01-01

    Cardiovascular disease is the primary cause of mortality and a major cause of disability worldwide. The dysfunction of the vascular endothelium is a pathological condition characterized mainly by a disruption in the balance between vasodilator and vasoconstrictor substances and is proposed to play an important role in the development of atherosclerotic cardiovascular disease. Therefore, a precise evaluation of endothelial function in humans represents an important tool that could help better understand the etiology of multiple cardio-centric pathologies. Over the past twenty-five years, many methodological approaches have been developed to provide an assessment of endothelial function in humans. Introduced in 1989, the FMD test incorporates a forearm occlusion and subsequent reactive hyperemia that promotes nitric oxide production and vasodilation of the brachial artery. The FMD test is now the most widely utilized, non-invasive, ultrasonic assessment of endothelial function in humans and has been associated with future cardiovascular events. Although the FMD test could have clinical utility, it is a physiological assessment that has inherited several confounding factors that need to be considered. This article describes a standardized protocol for determining FMD including the recommended methodology to help minimize the physiological and technical issues and improve the precision and reproducibility of the assessment. PMID:27167596

  10. Guidelines for the design of digital closed questions for assessment and learning in higher education

    NARCIS (Netherlands)

    Draaijer, S.; Hartog, R.J.M.

    2007-01-01

    Systems for computer based assessment as well as learning management systems offer a number of innovative closed question types, which are used more and more in higher education. These closed questions are used in computer based summative exams, in diagnostic tests, and in computer based activating

  11. [Operative guidelines for the shoe industry: risk assessment and environmental hygiene].

    Science.gov (United States)

    Paraluppi, Paolo

    2012-01-01

    Considering the most relevant factors for occupational safety and health, the Safety Check application in the footwear industry makes little and medium size factories employers able to carry out risk assessment. However, in specific cases, it is necessary to achieve an in-depth evaluation. PMID:22697034

  12. ECCC-guidelines for generation and assessment of weld creep data

    International Nuclear Information System (INIS)

    In the framework of the European Projects ''Weld Creep'' and ''Advanced Creep'', working group WG1 of the European Collaborative Creep Committee'' elaborated recommendations for Data Generation and Data Evaluation of creep rupture data of welded joints and the application in design and analysis. The recommendations are based on extensive investigations and round robin assessments of the members of working group 1. In this paper an overview on these activities and recommendations and some more detailed descriptions of development and application is given. In the recommendations for Data Generation test specimen design, test procedures and documentation as well as specific hints on the preparation of microstructures by thermal simulation to characterize the properties of heat affected zones in ferritic materials are addressed. The recommendations for Data Assessment include Data Evaluation and extrapolation, derivation of creep rupture curves and weld reduction factors. In order to develop these recommendations creep rupture data assessments were performed and compared by members of the working group on a number of typical working datasets. The results are included in a new issue of the Weld Data Assessment Volume of the ECCC recommendations. Finally, recommendations and experience obtained will be evaluated with respect to their application on components. (orig.)

  13. ECCC-guidelines for generation and assessment of weld creep data

    Energy Technology Data Exchange (ETDEWEB)

    Holdsworth, S.R. [EMPA, Swiss Federal Labs. for Materials Testing and Research (Switzerland); Klenk, A. [MPA, Univ. Stuttgart (Germany)

    2007-07-01

    In the framework of the European Projects ''Weld Creep'' and ''Advanced Creep'', working group WG1 of the European Collaborative Creep Committee'' elaborated recommendations for Data Generation and Data Evaluation of creep rupture data of welded joints and the application in design and analysis. The recommendations are based on extensive investigations and round robin assessments of the members of working group 1. In this paper an overview on these activities and recommendations and some more detailed descriptions of development and application is given. In the recommendations for Data Generation test specimen design, test procedures and documentation as well as specific hints on the preparation of microstructures by thermal simulation to characterize the properties of heat affected zones in ferritic materials are addressed. The recommendations for Data Assessment include Data Evaluation and extrapolation, derivation of creep rupture curves and weld reduction factors. In order to develop these recommendations creep rupture data assessments were performed and compared by members of the working group on a number of typical working datasets. The results are included in a new issue of the Weld Data Assessment Volume of the ECCC recommendations. Finally, recommendations and experience obtained will be evaluated with respect to their application on components. (orig.)

  14. 76 FR 21256 - Proposed Assessment Rate Adjustment Guidelines for Large and Highly Complex Institutions

    Science.gov (United States)

    2011-04-15

    ... (76 FR 10672 (Feb. 25, 2011)), the FDIC Board amended its assessment regulations (the Amended... FR 10672 (February 25, 2011) (to be codified at 12 CFR 327.9). \\2\\ A large institution is defined as...' non-lending interest income, fiduciary revenues, and investment banking fees, combined, exceed...

  15. Guidelines for Exposure Assessment in Health Risk Studies Following a Nuclear Reactor Accident

    OpenAIRE

    Bouville, André; Linet, Martha S.; Hatch, Maureen; Mabuchi, Kiyohiko; Simon, Steven L.

    2013-01-01

    Background: Worldwide concerns regarding health effects after the Chernobyl and Fukushima nuclear power plant accidents indicate a clear need to identify short- and long-term health impacts that might result from accidents in the future. Fundamental to addressing this problem are reliable and accurate radiation dose estimates for the affected populations. The available guidance for activities following nuclear accidents is limited with regard to strategies for dose assessment in health risk s...

  16. Assessing Educational Needs in Medical Practice: Guidelines for the CME Planning Committee Member

    OpenAIRE

    Jennett, P. A.; Laxdal, O. E.

    1984-01-01

    The most relevant and effective continuing medical education activities are those which address carefully identified and prioritized learning needs. As a consequence, discussions and activities of CME planning committees frequently focus upon the identification and assessment of physicians' educational needs. The physicians who serve as representatives of learners on such committees are often new to the planning, educational terms, approaches, and techniques. The basic ideas, definitions and ...

  17. JPN Guidelines for the management of acute pancreatitis: severity assessment of acute pancreatitis

    OpenAIRE

    Hirota, Masahiko; Takada, Tadahiro; Kawarada, Yoshifumi; Hirata, Koichi; Mayumi, Toshihiko; Yoshida, Masahiro; Sekimoto, Miho; Kimura, Yasutoshi; Takeda, Kazunori; ISAJI, Shuji; Koizumi, Masaru; Otsuki, Makoto; Matsuno, Seiki

    2006-01-01

    This article addresses the criteria for severity assessment and the severity scoring system of the Ministry of Health and Welfare of Japan; now the Japanese Ministry of Health, Labour, and Welfare (the JPN score). It also presents data comparing the JPN score with the Acute Physiology and Chronic Health Evaluation (APACHE) II score and the Ranson score, which are the major measuring scales used in the United States and Europe. The goal of investigating these scoring systems is the achievement...

  18. Ethically sound technology? Guidelines for interactive ethical assessment of personal health monitoring.

    Science.gov (United States)

    Palm, Elin; Nordgren, Anders; Verweij, Marcel; Collste, Göran

    2013-01-01

    Novel care-technologies possess a transformational potential. Future care and support may be provided via monitoring technologies such as smart devices, sensors, actors (robots) and Information and Communication Technologies. Such technologies enable care provision outside traditional care institutions, for instance in the homes of patients. Health monitoring may become "personalized" i.e. tailored to the needs of individual care recipients' but may also alter relations between care providers and care recipents, shape and form the care environment and influence values central to health-care. Starting out from a social constructivist theory of technology, an interactive ethical assessment-model is offered. The suggested model supplements a traditional analysis based on normative ethical theory (top-down approach) with interviews including relevant stakeholders (a bottom-up approach). This method has been piloted by small-scale interviews encircling stakeholder perspectives on three emerging technologies: (1) Careousel, a smart medicine-management device, (2) Robot Giraff, an interactive and mobile communication-device and (3) I-Care, a care-software that combines alarm and register system. By incorporating stakeholder perspectives into the analysis, the interactive ethical assessment model provides a richer understanding of the impact of PHM-technologies on ethical values than a traditional top-down model. If the assessment is conducted before the technology has reached the market - preferably in close interaction with developers and users - ethically sound technologies may be obtained. PMID:23920461

  19. Toward Guidelines for Population-level Ecological Risk Assessment: Results of a U.S. EPA Risk Assessment Forum Workshop

    Science.gov (United States)

    The choice of levels of biological organization reflected in ecological risk assessment (ERA) is receiving increasing attention. Most ERAs conducted for chemicals by the U.S. EPA, and indeed by most organizations worldwide, focus on organism-level attributes (e.g., survival, gro...

  20. Deliverable 4.3 Decision support guideline based on LCA and cost/efficiency assessment

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Hansen, Peter Augusto; Boyer-Souchet, Florence

    2010-01-01

    four clusters related to the main purpose of the treatment, e.g. nutrient removal or micropollutant removal. All are assessed within the cluster by comparing with the reference or by looking at induced versus avoided environmental impacts potentials originated from the various emissions and flows...... inventory of cluster 1 on micropollutant removal, tracks 22 organic micropollutants (pharmaceuticals) that have been sampled in different WWTTs by NEPTUNE partners. The resulting inventory is then modelled according to the EDIP97 methodology on the GaBi LCA modelling software, i.e. GaBi 4 (PE 2008), with...

  1. Critical features of peer assessment of clinical performance to enhance adherence to a low back pain guideline for physical therapists: a mixed methods design

    NARCIS (Netherlands)

    Maas, M.J.M.; Dulmen, S.A. van; Sagasser, M.H.; Heerkens, Y.F.; Vleuten, C.P.M. van der; Nijhuis, M.W.; Wees, P.J. van der

    2015-01-01

    BACKGROUND: Clinical practice guidelines are intended to improve the process and outcomes of patient care. However, their implementation remains a challenge. We designed an implementation strategy, based on peer assessment (PA) focusing on barriers to change in physical therapy care. A previously pu

  2. Assessment of Adaptive Reuse of Heritage Shop Houses for Sleep Lodging in Malaysia: Fulfilment of Conservation Guidelines

    OpenAIRE

    Othuman Mydin M.A.; Keling N.A.; Sani N. Md.; Abas N.F.

    2014-01-01

    This study focuses on the compliance of adaptive reuse of historic shop houses for sleep lodging with reference to the Guidelines for Conservation Areas and Heritage Buildings by Majlis Perbandaran Pulau Pinang (MPPP). Through this research, awareness towards the compliance of building conservation guidelines for heritage shop houses will be clarified accordingly. The goal of this study is to determine and extract vital clauses and components of Guidelines for Conservation Areas and Heritage ...

  3. Quantification of Fusarium graminearum and Fusarium culmorum by real-time PCR system and zearalenone assessment in maize

    International Nuclear Information System (INIS)

    Zearalenone (ZEA) is a mycotoxin produced by some species of Fusarium, especially by Fusarium grami- nearum and F. culmorum. ZEA induces hyperoestrogenic responses in mammals and can result in reproductive disorders in farm animals. In the present study, a real-time PCR (qPCR) assay has been successfully developed for the detection and quantification of Fusarium graminearum based on primers targeting the gene PKS13 involved in ZEA biosynthesis. A standard curve was developed by plotting the logarithm of known concentrations of F. graminearum DNA against the cycle threshold (Ct) value. The developed real time PCR system was also used to analyze the occurrence of zearalenone producing F. graminearum strains on maize. In this context, DNA extractions were performed from thirty-two maize samples, and subjected to real time PCR. Maize samples also were analyzed for zearalenone content by HPLC. F. graminearum DNA content (pg DNA/ mg of maize) was then plotted against ZEA content (ppb) in maize samples. The regression curve showed a positive and good correlation (R2 = 0.760) allowing for the estimation of the potential risk from ZEA contamination. Consequently, this work offers a quick alternative to conventional methods of ZEA quantification and mycological detection and quantification of F. graminearum in maize. (author)

  4. Targeting a polyketide synthase gene for Aspergillus carbonarius quantification and ochratoxin A assessment in grapes using real-time PCR

    International Nuclear Information System (INIS)

    Aspergillus carbonarius is an ochratoxin producing fungus that has been considered to be responsible of the ochratoxin A (OTA) contamination in grapes and wine. In order to monitor and quantify A. carbonarius, a specific primer pair Ac12RLOTAF/Ac12RLOTAR has been designed from the acyltransferase (AT) domain of the polyketide synthase sequence Ac12RL3 to amplify 141 bp PCR product. Among the mycotoxigenic fungi tested, only A. carbonarius gave a positive result. This specific primer pair was also successfully employed in real-time PCR conjugated with SYBR Green I dye for the direct quantification of this fungus in grape samples. A positive correlation (R2 = 0.81) was found between A. carbonarius DNA content and OTA concentration in 72 grape samples, allowing for the estimation of the potential risk from OTA contamination. Consequently, this work offers a quick alternative to conventional methods of OTA quantification and mycological detection and quantification of A. carbonarius in grapes. (author)

  5. General guidelines for the harmonisation of internal dose assessment: the Ideas Project

    International Nuclear Information System (INIS)

    The determination of internal doses is an essential component of individual monitoring programmes for workers. Assessment of internal doses can be divided into two phases: 1. determination of the amount of radioactive material in the human body by direct measurements and/or by indirect methods and 2. the interpretation of monitoring data in terms of intake and/or internal dose taking into account many influencing factors and assumptions, such as the physical and chemical characteristics of the radioactive substances, the mode of intake, the biokinetic and energy absorption processes, the individual parameters, etc. This second phase is particularly important because of the number of variables and uncertainties involved. Although the International Commission on Radiological Protection (ICRP) and International Atomic Energy Agency (IAEA) have published extensive tables of dose per unit intake (dose coefficients), these are default values based on assumptions about the intake parameters that may not be valid in specific situations

  6. Practice Guidelines for the Assessment of Clinically Significant Treatment Outcomes in the Children's Mental Health System.

    Science.gov (United States)

    Chomycz, Suzanne; Schmidt, Fred

    2016-01-01

    The use of program evaluation to monitor client change and improve intervention effectiveness is gaining increasing importance in the mental health field. However, there is a lack of literature available in community-based clinics for those who desire to evaluate the effectiveness of services. Through this article the authors review the literature on the best methods to assess clinically significant treatment outcomes in community-based children's mental health services. The strengths and weaknesses of commonly recommended methods of evaluating change are discussed (i.e., reliable change index, percentage of improvement, normative comparisons, and effect size) using a dataset from a community-based parenting program (N = 308). PMID:26086975

  7. Guidelines for Using Fallout Radionuclides to Assess Erosion and Effectiveness of Soil Conservation Strategies

    International Nuclear Information System (INIS)

    Soil degradation currently affects 1.9 billion hectares of agricultural land worldwide, and the area of degraded land is increasing rapidly at a rate of 5 to 7 million hectares each year. Most of this degradation is caused by inappropriate and poor land management practices in agriculture and livestock production. Among all degradation processes, including soil acidification, salinization and nutrient mining, soil erosion is by far the most common type of land degradation, accounting for 84% of affected areas, with more than three quarters of the affected surface land area located in developing countries. Current concerns about the impacts of soil erosion on crop productivity and the environment, as well as the deployment of effective soil conservation measures, have generated an urgent need to obtain reliable quantitative data on the extent and actual rates of soil erosion to underpin sustainable soil conservation strategies. The quest for new approaches for assessing soil erosion to complement conventional methods has led to the development of methodologies based on the use of fallout radionuclides (FRNs) as soil erosion tracers. With increasing attention being paid to land degradation worldwide, this publication explains and demonstrates FRN based methods to trace soil movement and to assess soil erosion at different spatial and temporal scales, and to evaluate the effectiveness of soil conservation strategies to ensure sustainable land management in agricultural systems. This publication summarizes the experiences and knowledge gained since the end of the 1990s in the use of FRNs by the IAEA and by scientists from both developed and developing countries involved in IAEA research networks. This publication provides guidance in the application of FRNs to stakeholders involved in sustainable agricultural development

  8. Validation of the MEDFICTS dietary questionnaire: A clinical tool to assess adherence to American Heart Association dietary fat intake guidelines

    Directory of Open Access Journals (Sweden)

    Bindeman Jody

    2003-06-01

    Full Text Available Abstract Background Dietary assessment tools are often too long, difficult to quantify, expensive to process, and largely used for research purposes. A rapid and accurate assessment of dietary fat intake is critically important in clinical decision-making regarding dietary advice for coronary risk reduction. We assessed the validity of the MEDFICTS (MF questionnaire, a brief instrument developed to assess fat intake according to the American Heart Association (AHA dietary "steps". Methods We surveyed 164 active-duty US Army personnel without known coronary artery disease at their intake interview for a primary prevention cardiac intervention trial using the Block food frequency (FFQ and MF questionnaires. Both surveys were completed on the same intake visit and independently scored. Correlations between each tools' assessment of fat intake, the agreement in AHA step categorization of dietary quality with each tool, and the test characteristics of the MF using the FFQ as the gold standard were assessed. Results Subjects consumed a mean of 36.0 ± 13.0% of their total calories as fat, which included saturated fat consumption of 13.0 ± 0.4%. The majority of subjects (125/164; 76.2% had a high fat (worse than AHA Step 1 diet. There were significant correlations between the MF and the FFQ for the intake of total fat (r = 0.52, P 70 [high fat diet] was negligible (kappa statistic = 0.036. The MF was accurate at the extremes of fat intake, but could not reliably identify the 3 AHA dietary classifications. Alternative MF cutpoints of 50 (high fat diet were highly sensitive (96%, but had low specificity (46% for a high fat diet. ROC curve analysis identified that a MF score cutoff of 38 provided optimal sensitivity 75% and specificity 72%, and had modest agreement (kappa = 0.39, P Conclusions The MEDFICTS questionnaire is most suitable as a tool to identify high fat diets, rather than discriminate AHA Step 1 and Step 2 diets. Currently recommended

  9. A dataset to assess providers׳ knowledge and attitudes towards the 2013 American College of Cardiology/American Heart Association Cholesterol Management Guideline.

    Science.gov (United States)

    Pokharel, Yashashwi; Steinberg, Lynne; Chan, Winston; Akeroyd, Julia M; Jones, Peter H; Nambi, Vijay; Nasir, Khurram; Petersen, Laura; Ballantyne, Christie M; Virani, Salim S

    2016-06-01

    We previously examined provider׳s understanding of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol management guideline (DOI: http://dx.doi.org/10.1016/j.jacl.2015.11.002)(Virani et al., 2013) [1], and also assessed whether a case-based educational intervention could improve providers׳ knowledge gaps and attitudes towards the guideline (DOI: 10.1016/j.atherosclerosis.2015.12.044) (Pokharel, et al., 2016) [2]. Here we describe the dataset that we used to examine our objectives. PMID:27054163

  10. PET optimization for improved assessment and accurate quantification of {sup 90}Y-microsphere biodistribution after radioembolization

    Energy Technology Data Exchange (ETDEWEB)

    Martí-Climent, Josep M., E-mail: jmmartic@unav.es; Prieto, Elena; Elosúa, César; Rodríguez-Fraile, Macarena; Domínguez-Prado, Inés; Vigil, Carmen; García-Velloso, María J.; Arbizu, Javier; Peñuelas, Iván; Richter, José A. [Nuclear Medicine Department, Clínica Universidad de Navarra, 36, Pío XII Avenue, 31008 Pamplona (Spain)

    2014-09-15

    Purpose: {sup 90}Y-microspheres are widely used for the radioembolization of metastatic liver cancer or hepatocellular carcinoma and there is a growing interest for imaging {sup 90}Y-microspheres with PET. The aim of this study is to evaluate the performance of a current generation PET/CT scanner for {sup 90}Y imaging and to optimize the PET protocol to improve the assessment and the quantification of {sup 90}Y-microsphere biodistribution after radioembolization. Methods: Data were acquired on a Biograph mCT-TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling. Spatial resolution was measured with a{sup 90}Y point source. Sensitivity was evaluated using the NEMA 70 cm line source filled with {sup 90}Y. To evaluate the count rate performance, {sup 90}Y vials with activity ranging from 3.64 to 0.035 GBq were measured in the center of the field of view (CFOV). The energy spectrum was evaluated. Image quality with different reconstructions was studied using the Jaszczak phantom containing six hollow spheres (diameters: 31.3, 28.1, 21.8, 16.1, 13.3, and 10.5 mm), filled with a 207 kBq/ml {sup 90}Y concentration and a 5:1 sphere-to-background ratio. Acquisition time was adjusted to simulate the quality of a realistic clinical PET acquisition of a patient treated with SIR-Spheres{sup ®}. The developed methodology was applied to ten patients after SIR-Spheres{sup ®} treatment acquiring a 10 min per bed PET. Results: The energy spectrum showed the{sup 90}Y bremsstrahlung radiation. The {sup 90}Y transverse resolution, with filtered backprojection reconstruction, was 4.5 mm in the CFOV and degraded to 5.0 mm at 10 cm off-axis. {sup 90}Y absolute sensitivity was 0.40 kcps/MBq in the center of the field of view. Tendency of true and random rates as a function of the {sup 90}Y activity could be accurately described using linear and quadratic models, respectively. Phantom studies demonstrated that, due to low count statistics in {sup 90}Y PET

  11. Inconsistencies in clinical guidelines for obstetric anaesthesia for Caesarean section

    DEFF Research Database (Denmark)

    Winther, Lars; Mitchell, A U; Møller, Ann

    2013-01-01

    Anaesthetists need evidence-based clinical guidelines, also in obstetric anaesthesia. We compared the Danish, English, American, and German national guidelines for anaesthesia for Caesarean section. We focused on assessing the quality of guideline development and evaluation of the guidelines...

  12. A French guideline for defect assessment at elevated temperature and leak before break analysis

    Energy Technology Data Exchange (ETDEWEB)

    Drubay, B.; Chapuliot, St.; Lacire, M.H.; Marie, St. [CEA Saclay, Lab. d' Ingegrite des Structures et Normalisation, LISN, 91 - Gif sur Yvette (France); Deschanels, H. [FRAMATOME/Novatome, 69 - Lyon (France); Cambefort, P. [Electricite de France (EDF/SEPTEN), 69 - Lyon (France)

    2001-07-01

    A large program is performed in France in order to develop, for the design and operating FBR (fast breeder reactor) plants, defect assessment procedures and Leak-Before-Break methods (L.B.B.). The main objective of this A16 guide is to propose analytical solutions at elevated temperature coherent with those proposed at low temperature by the RSE-M. The main items developed in this A16 guide for laboratory specimen, plates, pipes and elbows are the following: evaluation of ductile crack initiation and crack propagation based on the J parameter and material characteristics as J{sub R}-{delta}a curve or J{sub i}/G{sub fr}. Algorithms to evaluate the maximum endurable load under increasing load for through wall cracks or surface cracks are also proposed; determination of fatigue or creep-fatigue crack initiation based on the {sigma} approach calculating stress and strain at a characteristic distance d from the crack tip; evaluation of fatigue crack growth based on da/dN-{delta}K{sub eff} relationship with a {delta}K{sub eff} derived from a simplified estimation of {delta}J for the cyclic load; evaluation of creep-fatigue crack growth adding the fatigue crack growth and the creep crack growth during the hold time derived from a simplified evaluation of C{sup *}; Leak-Before-Break procedure. The fracture mechanic parameters determined in the A16 guide (K{sub 1}, J, C{sup *}) are derived from handbooks and formula in accordance with those proposed in the RSE-M document for in service inspection. Those are: the K{sub I} handbook for a large panel of surface and through-wall defect in plates, pipes and elbows; elastic stress and reference stress formula; analytical Js and Cs{sup *} formulations for mechanical and through thickness thermal load. The main part of the formula and assessment methodologies proposed in the A16 guide are included in a software, called MJSAM, developed under the MS Windows environment in support of the document. This allows a simple application of

  13. A French guideline for defect assessment at elevated temperature and leak before break analysis

    International Nuclear Information System (INIS)

    A large program is performed in France in order to develop, for the design and operating FBR (fast breeder reactor) plants, defect assessment procedures and Leak-Before-Break methods (L.B.B.). The main objective of this A16 guide is to propose analytical solutions at elevated temperature coherent with those proposed at low temperature by the RSE-M. The main items developed in this A16 guide for laboratory specimen, plates, pipes and elbows are the following: evaluation of ductile crack initiation and crack propagation based on the J parameter and material characteristics as JR-Δa curve or Ji/Gfr. Algorithms to evaluate the maximum endurable load under increasing load for through wall cracks or surface cracks are also proposed; determination of fatigue or creep-fatigue crack initiation based on the σ approach calculating stress and strain at a characteristic distance d from the crack tip; evaluation of fatigue crack growth based on da/dN-ΔKeff relationship with a ΔKeff derived from a simplified estimation of ΔJ for the cyclic load; evaluation of creep-fatigue crack growth adding the fatigue crack growth and the creep crack growth during the hold time derived from a simplified evaluation of C*; Leak-Before-Break procedure. The fracture mechanic parameters determined in the A16 guide (K1, J, C*) are derived from handbooks and formula in accordance with those proposed in the RSE-M document for in service inspection. Those are: the KI handbook for a large panel of surface and through-wall defect in plates, pipes and elbows; elastic stress and reference stress formula; analytical Js and Cs* formulations for mechanical and through thickness thermal load. The main part of the formula and assessment methodologies proposed in the A16 guide are included in a software, called MJSAM, developed under the MS Windows environment in support of the document. This allows a simple application of the analysis proposed in the document. (authors)

  14. Quality Guidelines

    Science.gov (United States)

    ... www.nlm.nih.gov/medlineplus/criteria.html MedlinePlus Quality Guidelines To use the sharing features on this ... materials must also meet our existing quality guidelines. Quality, authority and accuracy of health content The organization's ...

  15. Wind generation systems for remote communities: market assessment and guidelines for wind turbines selection

    International Nuclear Information System (INIS)

    Wind technology and its market potential in remote communities of the Canadian North were discussed. These communities, unserviced by the main utility electricity grid, generate their own electricity using high quality, expensive diesel fuel to power diesel driven generators. The logistics of delivering fuel to these remote communities is an expensive operation. Wind resource in many of these communities is substantial and wind energy is seen as a prime candidate for supplying electricity to many potential sites in the Arctic and also areas in Quebec and Newfoundland. However, the severe service (i.e., cold climate, remote locations with limited facilities) requires special considerations to ensure that equipment installed performs reliably. This report described some demonstration projects in northern Canada over the last ten years, where an understanding of the special needs of wind turbines in remote areas has been developed. A guide which assessed the suitability of wind turbines for Arctic applications was included to assist organisations in preparing requirements to be used in acquiring wind turbines for use in cold regions. Refs., tabs., figs

  16. Multimedia Environmental Pollutant Assessment System (MEPAS) application guidance. Guidelines for evaluating MEPAS input parameters for Version 3.1

    International Nuclear Information System (INIS)

    The Multimedia Environmental Pollutant Assessment System (MEPAS) was developed by Pacific Northwest Laboratory (PNL) for the U.S. Department of Energy (DOE) Office of Environment, Safety and Health and Office of Environmental Management and Environmental Restoration. MEPAS is a set of computer codes developed to provide decision makers with risk information integrated for hazardous, radioactive, and mixed-waste sites based on their potential hazard to public health. It is applicable to a wide range of environmental management and regulatory conditions, including inactive sites covered under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and active air and water releases covered under the Clean Air Act, the Clean Water Act, and the Resource Conservation and Recovery Act. MEPAS integrates contaminant release, transport, and exposure models into a single system. An interactive user interface assists the investigator in defining problems, assembling data and entering input, and developing reports. PNL has compiled two documents that explain the methodology behind the MEPAS model and instruct the user in how to input, retrieve, and evaluate data. This report contains detailed guidelines for defining the input data required to conduct an analysis with MEPAS. Entries for each variable have a short definition, units, and text explaining what a variable is and how it can be quantified. As appropriate, ranges and typical values are given. This report also contains listings of the input screens (worksheets) that are used in the MEPAS user interface for these variables

  17. Guidelines and workbook for assessment of organization and administration of utilities seeking operating license for a nuclear power plant. Guidelines for utility organization and administration plan. Volume 1, Revision 1

    International Nuclear Information System (INIS)

    Volumes 1 and 2 of this report are a partial response to the requirements of Item I.B.1.1 of the ''NRC Action Plan Developed as a Result of the TMI-2 Accident,'' NUREG-0660, and are designed to serve as a basis for replacing the earlier NUREG-0731, ''Guidelines for Utility Management Structure and Technical Resources.'' These Guidelines are intended to provide guidance to the user in preparing a written plan for a proposed nuclear organization and administration. The purpose of the Workbook (Vol. 2) is to guide the NRC reviewer through a systematic review and assessment of a proposed organization and administration. It is the NRC's intention to incorporate these Guidelines and Workbook into a future revision of the Standard Review Plan (SRP), NUREG-0800. However, at this time the report is being published so that the material may be used on a voluntary basis by industry to systematically prepare or evaluate their organization or administration plans. Use of the report by the NRC would not occur until after it has been incorpoarted in the SRP

  18. Quantification of urban metabolism through coupling with the life cycle assessment framework: concept development and case study

    DEFF Research Database (Denmark)

    Goldstein, Benjamin Paul; Birkved, Morten; Quitzau, Maj-Britt;

    2013-01-01

    of cities by modeling pressures embedded in the flows upstream (entering) and downstream (leaving) of the actual urban systems studied, and by introducing an advanced suite of indicators. Applied to five global cities, the developed UM–LCA model provided enhanced quantification of mass and energy...... flows through cities over earlier UM methods. The hybrid model approach also enabled the dominant sources of a city’s different environmental footprints to be identified, making UM–LCA a novel and potentially powerful tool for policy makers in developing and monitoring urban development policies...

  19. Overview of resulting tools, guidelines, and instruments. IN-SAFETY Workpackage 3: New models, tools and guidelines for road safety assessment, Deliverable 3.4.

    OpenAIRE

    Dijkstra, A. Bald, S. Benz, T. & Gaitanidou, E. (eds.)

    2009-01-01

    Road safety will most probably be influenced by introducing Advanced Driver Assistance Systems (ADAS) or Intelligent Vehicle Safety Systems (IVSS). The effects of these systems on road safety can be assessed in different ways. This document gives a short overview of methodologies which allow for assessing road safety effects (Chapter 2), This Deliverable gives an overview of the outcome of work package 3 of IN-SAFETY. Two methodologies have basically been applied: • simulation model • risk an...

  20. Overview of resulting tools, guidelines, and instruments. IN-SAFETY Workpackage 3: New models, tools and guidelines for road safety assessment, Deliverable 3.4.

    NARCIS (Netherlands)

    Dijkstra, A. Bald, S. Benz, T. & Gaitanidou, E. (eds.)

    2009-01-01

    Road safety will most probably be influenced by introducing Advanced Driver Assistance Systems (ADAS) or Intelligent Vehicle Safety Systems (IVSS). The effects of these systems on road safety can be assessed in different ways. This document gives a short overview of methodologies which allow for ass

  1. Utility of routine data sources for feedback on the quality of cancer care: an assessment based on clinical practice guidelines

    Directory of Open Access Journals (Sweden)

    Baade Peter

    2009-05-01

    Full Text Available Abstract Background Not all cancer patients receive state-of-the-art care and providing regular feedback to clinicians might reduce this problem. The purpose of this study was to assess the utility of various data sources in providing feedback on the quality of cancer care. Methods Published clinical practice guidelines were used to obtain a list of processes-of-care of interest to clinicians. These were assigned to one of four data categories according to their availability and the marginal cost of using them for feedback. Results Only 8 (3% of 243 processes-of-care could be measured using population-based registry or administrative inpatient data (lowest cost. A further 119 (49% could be measured using a core clinical registry, which contains information on important prognostic factors (e.g., clinical stage, physiological reserve, hormone-receptor status. Another 88 (36% required an expanded clinical registry or medical record review; mainly because they concerned long-term management of disease progression (recurrences and metastases and 28 (11.5% required patient interview or audio-taping of consultations because they involved information sharing between clinician and patient. Conclusion The advantages of population-based cancer registries and administrative inpatient data are wide coverage and low cost. The disadvantage is that they currently contain information on only a few processes-of-care. In most jurisdictions, clinical cancer registries, which can be used to report on many more processes-of-care, do not cover smaller hospitals. If we are to provide feedback about all patients, not just those in larger academic hospitals with the most developed data systems, then we need to develop sustainable population-based data systems that capture information on prognostic factors at the time of initial diagnosis and information on management of disease progression.

  2. Quantification of source uncertainties in Seismic Probabilistic Tsunami Hazard Analysis (SPTHA): towards PTHA assessment for the coasts of Italy

    Science.gov (United States)

    Selva, Jacopo; Tonini, Roberto; Molinari, Irene; Tiberti, Mara M.; Romano, Fabrizio; Grezio, Anita; Melini, Daniele; Piatanesi, Alessio; Basili, Roberto; Lorito, Stefano

    2016-04-01

    We propose a procedure for uncertainty quantification in Probabilistic Tsunami Hazard Analysis (PTHA), with a special emphasis on the uncertainty related to statistical modelling of the earthquake source in Seismic PTHA (SPTHA), and on the separate treatment of subduction and crustal earthquakes. Differently from classical approaches that commonly adopt the hazard integral and logic tree, we use an event tree approach and ensemble modelling. The procedure was developed in the framework of the EC projects ASTARTE and STREST, of the Italian National Flagship project RITMARE, and of the agreement between Italian Civil Protection and INGV. A total of about 2 × 107 different potential seismic sources covering the entire Mediterranean Sea, and more than 1 × 105 alternative model implementations have been considered to quantify both the aleatory variability and the epistemic uncertainty. A set of hazard curves is obtained along the coasts of the entire Italian territory. They are the prototype of the first homogeneous Italian national SPTHA map.

  3. ECONOMIC ANALYSIS OF ENVIRONMENTAL REGULATIONS: APPLICATION OF THE RANDOM UTILITY MODEL TO RECREATIONAL BENEFIT ASSESSMENT FOR THE MP&M EFFLUENT GUIDELINE

    OpenAIRE

    Tudor, Lynne G.; Besedin, Elena Y.; Fisher, Michael; Smith, Stuart

    1999-01-01

    The present study focuses on a state-wide case study to evaluate recreational benefits from forthcoming effluent limitation guidelines for the Metal Products and Machinery Industry. The study combines water quality modeling and a random utility model to assess how changes in water quality from the regulation will affect consumer valuation of water resources. Based on preliminary results, the MP&M regulation has the potential to generate substantial recreational benefits in Ohio.

  4. The fish sexual development test: an OECD test guideline proposal with possible relevance for environmental risk assessment. Results from the validation programme

    DEFF Research Database (Denmark)

    Holbech, Henrik; Brande-Lavridsen, Nanna; Kinnberg, Karin Lund;

    2010-01-01

    The Fish Sexual Development Test (FSDT) has gone through two validations as an OECD test guideline for the detection of endocrine active chemicals with different modes of action. The validation has been finalized on four species: Zebrafish (Danio rerio), Japanese medaka (Oryzias latipes), three s...... as a population relevant endpoint and the results of the two validation rounds will be discussed in relation to environmental risk assessment and species selection....

  5. Development of a diet quality index assessing adherence to the Swedish nutrition recommendations and dietary guidelines in the Malmö Diet and Cancer cohort.

    OpenAIRE

    Drake, Isabel; Gullberg, Bo; Ericson, Ulrika; Sonestedt, Emily; Nilsson, Jan; Wallström, Peter; Hedblad, Bo; Wirfält, Elisabet

    2011-01-01

    OBJECTIVE: To develop a diet quality index (DQI) that assesses adherence to the Swedish nutrition recommendations (SNR) and the Swedish dietary guidelines (SDG). DESIGN: A cross-sectional study within the Malmö Diet and Cancer (MDC) cohort. A diet history method collected dietary data, a structured questionnaire lifestyle and socio-economic information, and anthropometric data were collected by direct measurements. The index (DQI-SNR) included six components: SFA, PUFA, fish and shellfish, di...

  6. Developing a national food defense guideline based on a vulnerability assessment of intentional food contamination in Japanese food factories using the CARVER+Shock vulnerability assessment tool.

    Science.gov (United States)

    Kanagawa, Yoshiyuki; Akahane, Manabu; Hasegawa, Atsushi; Yamaguchi, Kentaro; Onitake, Kazuo; Takaya, Satoshi; Yamamoto, Shigeki; Imamura, Tomoaki

    2014-12-01

    The awareness of food terrorism has increased following the September 11, 2001 terrorist attacks in New York City, United States, and many measures and policies dealing with this issue have been established worldwide. Suspected deliberate food-poisoning crimes have occurred in Japan, although they are not regarded as acts of food terrorism. One area of concern is that the small- to medium-sized companies that dominate Japan's food industry are extremely vulnerable to deliberate food poisoning. We conducted a literature research on food defense measures undertaken by the World Health Organization and in the United States and Europe. Using the Carver+Shock vulnerability assessment tool, eight food factories and related facilities in Japan were evaluated and we found the level of awareness of food defense to be low and the measures inappropriate. On the basis of this evaluation, we developed a set of guidelines that Japanese food companies can use to help develop their food defense strategies and to serve as a reference in considering specific measures. PMID:25496071

  7. Novel phase-based noise reduction strategy for quantification of left ventricular function and mass assessment by cardiac CT: Comparison with cardiac magnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Wai, Bryan, E-mail: bwai@partners.org [Cardiac MR PET CT Program, Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Thai, Wai-ee [Cardiac MR PET CT Program, Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Brown, Heather [Qi Imaging, Redwood City, California (United States); Truong, Quynh A. [Cardiac MR PET CT Program, Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)

    2013-08-15

    Background: Tube current modulation in retrospective ECG gated cardiac computed tomography (CT) results in increased image noise and may reduce the accuracy of left ventricular (LV) ejection fraction (EF) and mass assessment. Objective: To examine the effects of a novel CT phase-based noise reduction (NR) algorithm on LV EF and mass quantification as compared to cardiac magnetic resonance (CMR). Methods: In 40 subjects, we compared the LV EF and mass between CT and CMR. In a subset of 24 subjects with tube current modulated CT, the effect of phase-based noise reduction strategies on contrast-to-noise ratio (CNR) and the assessment of LV EF and mass was compared to CMR. Results: There was excellent correlation between CT and CMR for EF (r = 0.94) and mass (r = 0.97). As compared to CMR, the limits of agreement improved with increasing strength of NR strategy. There was a systematic underestimation of LV mass by CT compared to CMR with no NR (−10.3 ± 10.1 g) and low NR (−10.3 ± 12.5 g), but was attenuated with high NR (−0.5 ± 8.3 g). Studies without NR had lower CNR compared to low and high NR at both the ES phase and ED phase (all p < 0.01). Conclusions: A high NR strategy on tube current modulated functional cardiac CT improves correlation of EF compared to CMR and reduces variability of EF and mass evaluation by increasing the CNR. In an effort to reduce radiation dose with tube current modulation, this strategy provides better image quality when LV function and mass quantification is needed.

  8. Novel phase-based noise reduction strategy for quantification of left ventricular function and mass assessment by cardiac CT: Comparison with cardiac magnetic resonance

    International Nuclear Information System (INIS)

    Background: Tube current modulation in retrospective ECG gated cardiac computed tomography (CT) results in increased image noise and may reduce the accuracy of left ventricular (LV) ejection fraction (EF) and mass assessment. Objective: To examine the effects of a novel CT phase-based noise reduction (NR) algorithm on LV EF and mass quantification as compared to cardiac magnetic resonance (CMR). Methods: In 40 subjects, we compared the LV EF and mass between CT and CMR. In a subset of 24 subjects with tube current modulated CT, the effect of phase-based noise reduction strategies on contrast-to-noise ratio (CNR) and the assessment of LV EF and mass was compared to CMR. Results: There was excellent correlation between CT and CMR for EF (r = 0.94) and mass (r = 0.97). As compared to CMR, the limits of agreement improved with increasing strength of NR strategy. There was a systematic underestimation of LV mass by CT compared to CMR with no NR (−10.3 ± 10.1 g) and low NR (−10.3 ± 12.5 g), but was attenuated with high NR (−0.5 ± 8.3 g). Studies without NR had lower CNR compared to low and high NR at both the ES phase and ED phase (all p < 0.01). Conclusions: A high NR strategy on tube current modulated functional cardiac CT improves correlation of EF compared to CMR and reduces variability of EF and mass evaluation by increasing the CNR. In an effort to reduce radiation dose with tube current modulation, this strategy provides better image quality when LV function and mass quantification is needed

  9. Guidelines on the scope, content, and use of comprehensive risk assessment in the management of high-level nuclear waste transportation

    International Nuclear Information System (INIS)

    This report discusses the scope of risk assessment strategies in the management of the transport of high-level radioactive wastes. In spite of the shortcomings of probabilistic risk assessment(PRA), the Transportation Needs Assessment recommended this as the preferred methodology to assess the risks of high level nuclear waste (HLNW) transportation. A PRA also will need to heed the lessons learned from the development and application of PRA elsewhere, such as in the nuclear power industry. A set of guidelines will aid this endeavor by outlining the appropriate scope, content, and use of a risk assessment which is more responsive to the uncertainties, human-technical interactions, social forces, and iterative relationship with risk management strategies, than traditional PRAS. This more expansive definition, which encompasses but is not totally reliant on rigorous data requirements and quantitative probability estimates, we term Comprehensive Risk Assessment (CRA) Guidelines will be developed in three areas: the limitations of existing methodologies and suggested modifications; CRA as part of a flexible, effective, adaptive risk management system for HLNW transportation; and, the use of CRA in risk communication

  10. Assessing the impact of the U.S. Endangered Species Act recovery planning guidelines on managing threats for listed species.

    Science.gov (United States)

    Troyer, Caitlin M; Gerber, Leah R

    2015-10-01

    The Endangered Species Act (ESA) of the United States was enacted in 1973 to prevent the extinction of species. Recovery plans, required by 1988 amendments to the ESA, play an important role in organizing these efforts to protect and recover species. To improve the use of science in the recovery planning process, the Society for Conservation Biology (SCB) commissioned an independent review of endangered species recovery planning in 1999. From these findings, the SCB made key recommendations for how management agencies could improve the recovery planning process, after which the U.S. Fish and Wildlife Service and the National Marine Fisheries Service redrafted their recovery planning guidelines. One important recommendation called for recovery plans to make threats a primary focus, including organizing and prioritizing recovery tasks for threat abatement. We sought to determine the extent to which results from the SCB study were incorporated into these new guidelines and whether the SCB recommendations regarding threats manifested in recovery plans written under the new guidelines. Recovery planning guidelines generally incorporated the SCB recommendations, including those for managing threats. However, although recent recovery plans have improved in their treatment of threats, many fail to adequately incorporate threat monitoring. This failure suggests that developing clear guidelines for monitoring should be an important priority in improving ESA recovery planning. PMID:26108948

  11. Towards the production of reliable quantitative microbiological data for risk assessment: Direct quantification of Campylobacter in naturally infected chicken fecal samples using selective culture and real-time PCR

    DEFF Research Database (Denmark)

    Garcia Clavero, Ana Belén; Vigre, Håkan; Josefsen, Mathilde Hasseldam

    2015-01-01

    Poultry has been identified as a significant source for human campylobacteriosis which constitutes an important zoonosis and public health problem in many areas of the world. Rapid, direct and accurate quantification of Campylobacter in poultry is essential for the assessment of public health risks...

  12. Clinical guidelines.

    Science.gov (United States)

    Uppal, Elaine

    2016-01-01

    This article is part of the Advancing practice series which is aimed at exploring practice issues in more depth, considering topics that are frequently encountered and facilitating the development of new insights. Elaine Uppal focuses on the importance of all midwives developing guideline writing skills to ensure that local, national and international midwifery/maternity guidelines are up to date, relevant and reflect midwifery knowledge alongside 'gold' standard evidence. The article aims to consider the development, use and critical appraisal of clinical guidelines. It will define and explain guidelines; discuss their development and dissemination; and consider issues relating to their use in practice. Techniques to critique and develop guidelines using the AGREE tool will be outlined in the form of practice challenges to be undertaken by the individual or in a group. PMID:26975126

  13. ASSET guidelines

    International Nuclear Information System (INIS)

    The IAEA Assessment of Safety Significant Events Team (ASSET) Service provides advice and assistance to Member States to enhance the overall level of plant safety while dealing with the policy of prevention of incidents at nuclear power plants. The ASSET programme, initiated in 1986, is not restricted to any particular group of Member States, whether developing or industrialized, but is available to all countries with nuclear power plants in operation or approaching commercial operation. The IAEA Safety Series publications form common basis for the ASSET reviews, including the Nuclear Safety Standards (NUSS) and the Basic Safety Principles (Recommendations of Safety Series No. 75-INSAG-3). The ASSET Guidelines provide overall guidance for the experts to ensure the consistency and comprehensiveness of their review of incident investigations. Additional guidance and reference material is provided by the IAEA to complement the expertise of the ASSET members. ASSET reviews accept different approaches that contribute to ensuring an effective prevention of incidents at plants. Suggestions are offered to enhance plant safety performance. Commendable good practices are identified and generic lessons are communicated to other plants, where relevant, for long term improvement

  14. Assessment of automatic quantification of myocardial perfusion and left ventricular function derived from ECG gated myocardial SPECT with {sup 99m}Tc-tetrofosmin in ischemic heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Mitsunori; Habara, Hirokazu; Tatsuno, Hironari; Fukuda, Hiroshi; Hamada, Noriko; Kazatani, Yukio [Ehime Prefectural Central Hospital (Japan)

    1999-09-01

    Non-invasive assessment of ischemic heart disease (IHD) requires information of both myocardial perfusion and left ventricular (LV) function. Recently, automatic quantification of ECG-gated myocardial scintigraphy with {sup 99m}Tc-tetrofosmin (QGS) can provide both of them. QGS, coronary angiograms (CAG) and left venticulograms (LVG) were performed in 83 patients with severe IHD in same period. Significant stenosis of coronary artery in CAG were assessed by QGS. The sensitivity, specificity and accuracy of significant stenosis by QGS was excellent (85%, 93% and 88%). The LV end-distolic and end-systolic volumes (EDV and ESV), LV ejection fraction (EF) and regional LV wall motion determined by QGS were compared to LVG. There was a good correlation between the values obtained from QGS and LVG (EDV: r=0.86, ESV: r=0.94, EF: r=0.84, p<0.0001), but QGS tended to underestimate EDV and EF. High complete agreement of regional LV wall motion was gained with 427 (74.0%) out of total 581 segments. In conclusion, QGS data was considered to be useful for assessment of determine significant stenosis and LV function in severe IHD. (author)

  15. Assessing metal toxicity in sediments using the equilibrium partitioning model and empirical sediment quality guidelines: A case study in the nearshore zone of the Bohai Sea, China

    International Nuclear Information System (INIS)

    Highlights: • Based on the EqP model, 35% samples had potential metal toxicity in sediments. • The empirical SQGs are not suitable for assessing sediment toxicity in Bohai Sea. • The EqP model is a much needed tool for metal toxicity assessment in coastal China. - Abstract: Surface sediments were collected from five nearshore (wastewater discharges, aquaculture facilities and a seaport) sites in Bohai Bay and Laizhou Bay, China. The equilibrium partitioning (EqP) model and empirical sediment quality guidelines (SQGs) were applied to assess the potential metal toxicity in the collected sediments. The results show that, based on the EqP model, 35% of stations exhibited potential metal toxicity. Several metals (Cu, Ni and Cr) exceeded the empirical SQGs (9–93% of the time), however these guidelines may not be suitable for use in the Bohai Sea owing to the background concentrations. The EqP model is a more useful method for assessing potential metal toxicity in Bohai Sea sediment than the empirical SQGs. Additionally, we have provided new understanding about methods for assessing sediment metal toxicity in the Bohai Sea that may be useful in other coastal areas in China

  16. Assessing racial/ethnic disparities in chemotherapy treatment among breast cancer patients in context of changing treatment guidelines

    OpenAIRE

    Silva, Abigail; Rauscher, Garth H.; Hoskins, Kent; Rao, Ruta; Ferrans, Carol Estwing

    2013-01-01

    Conflicting study results with regards to racial/ethnic disparities in chemotherapy use among breast cancer patients may be due to the different sample populations, treatment data sources, and treatment eligibility definitions used. This study examined chemotherapy disparity in the context of changing treatment guidelines and explored factors that may help explain treatment differences observed.

  17. Examining guidelines for the site selection for geological disposal. Research activities principle for future risk assessment and quality assurance

    International Nuclear Information System (INIS)

    A draft for the committee in charge of nuclear safety regulations regarding geological disposal of high-level radioactive wastes from nuclear facilities is presented. The report particularly concerns with a line of policy or principle at the stage of investigation activities for the site selection and site characterization. IAEA guidelines are consulted. (S. Ohno)

  18. Risk management guidelines

    International Nuclear Information System (INIS)

    Northeast Utilities (NU) has developed and implemented a comprehensive probabilistic safety assessment (PSA) program in support of nuclear power plant engineering and operations. Included in this program is a formal policy statement on nuclear safety goals; formalized procedures for review of all plant design changes; a formal procedure for prioritizing new projects; and at least level 1 probabilistic safety studies on all four NU-operated nuclear units. A procedure on risk communication to senior management has also been implemented. This procedure was recently amended to provide quantitative guidelines for determining the acceptability of issues affecting risk. The guidelines described are believed to be unique to the utility industry. The guidelines provide consistency and delineation of authority in making risk management decisions. They are also intended to complement, rather than substitute for, other means of determining the acceptability of plant changes and conditions. Implementation of these guidelines illustrates the strong support that NU senior management has for PRA methods

  19. Proceedings: MAAP thermal-hydraulic qualifications and guidelines for plant application workshop

    International Nuclear Information System (INIS)

    This workshop was held in Houston, November 15--16, 1990. It was organized as a technology-transfer activity, intended to provide utilities and others in the industry with the results of much-needed plan applications. The workshop focused on the MAAP thermal-hydraulic qualification program, selection of risk-dominant scenarios and thermal-hydraulic phenomena, PWR and BWR assessments, plant-specific applications, quantification of success criteria and probabilistic risk assessment (PRA) applications, and use of results for IPEs and application guidelines. Individual papers have been cataloged separately

  20. Metadata Guidelines

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document provides guidelines on metadata and metadata requirements for ServCat documents. Information on metadata is followed by an instructional flowchart and...

  1. Author Guidelines

    OpenAIRE

    Chief Editor

    2015-01-01

    Author GuidelinesIJCH strictly adheres on the recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals as per the standard universal guidelines given by International Committee of Medical Journal Editors (ICMJE - Recommendations for Uniform Requirements for Manuscripts). Authors are requested to visit http://www.icmje.org/index.html before making online submission of their manuscript(s).SectionsEditorial:On issues of current public health needA...

  2. OSART guidelines

    International Nuclear Information System (INIS)

    The IAEA Operational Safety Review Team (OSART) programme provides advice and assistance to Member States to enhance the operational safety of nuclear power plants. These OSART Guidelines provide overall guidance for the experts to ensure the consistency and comprehensiveness of the operational safety review. Specific guidelines are provided as guide for the systematic review in the following areas important to operational safety: management, organization and administration, training and qualification, operations, maintenance, technical support, radiation protection, chemistry, emergency planning and preparedness

  3. Advancing agricultural greenhouse gas quantification*

    Science.gov (United States)

    Olander, Lydia; Wollenberg, Eva; Tubiello, Francesco; Herold, Martin

    2013-03-01

    , multiple development goals can be reinforced by specific climate funding granted on the basis of multiple benefits and synergies, for instance through currently negotiated mechanisms such as Nationally Appropriate Mitigation Actions (NAMAs) (REDD+, Kissinger et al 2012). 3. Challenges to quantifying GHG information for the agricultural sector The quantification of GHG emissions from agriculture is fundamental to identifying mitigation solutions that are consistent with the goals of achieving greater resilience in production systems, food security, and rural welfare. GHG emissions data are already needed for such varied purposes as guiding national planning for low-emissions development, generating and trading carbon credits, certifying sustainable agriculture practices, informing consumers' choices with regard to reducing their carbon footprints, assessing product supply chains, and supporting farmers in adopting less carbon-intensive farming practices. Demonstrating the robustness, feasibility, and cost effectiveness of agricultural GHG inventories and monitoring is a necessary technical foundation for including agriculture in the international negotiations under the United Nations Framework Convention on Climate Change (UNFCCC), and is needed to provide robust data and methodology platforms for global corporate supply-chain initiatives (e.g., SAFA, FAO 2012). Given such varied drivers for GHG reductions, there are a number of uses for agricultural GHG information, including (1) reporting and accounting at the national or company level, (2) land-use planning and management to achieve specific objectives, (3) monitoring and evaluating impact of management, (4) developing a credible and thus tradable offset credit, and (5) research and capacity development. The information needs for these uses is likely to differ in the required level of certainty, scale of analysis, and need for comparability across systems or repeatability over time, and they may depend on whether

  4. Environmental risk assessment for new human pharmaceuticals in the European Union according to the draft guideline/discussion paper of January 2001.

    Science.gov (United States)

    Straub, Jürg Oliver

    2002-10-01

    Since 1993, an environmental risk assessment (ERA) for a new drug application has been stipulated by EU Directive 93/39/EEC amending Directive 65/65/EEC. In early 2001, after several unpublished draft versions for an ERA guideline, a draft guideline/discussion paper for an ERA for non-GMO-containing drugs was published by the European Medicines Evaluation Agency (EMEA). The draft guideline describes a step-wise, tiered procedure for the ERA. The first tier consists of deriving a crude predicted environmental concentration (PEC) in the aquatic compartment for the active pharmaceutical ingredient (API) or its major metabolites, based on predicted amounts used and specific removal rates in sewage treatment or surface waters. If this crude PEC is labelling (i.e. package leaflets for the patients regarding returning and proper disposal of unused medicines), restricted use through in-hospital or in-surgery administration under supervision only, or the recommendation of environmental analytical monitoring up to ecological field studies. PMID:12270681

  5. The assessment of sediment screening risk in Venice Lagoon and other coastal areas using international sediment quality guidelines

    International Nuclear Information System (INIS)

    A number of studies carried out in recent years have shown the presence of a wide range of contaminants in the Venice Lagoon. It is important to have a good understanding of the ecological quality of Venice Lagoon sediments, in order to: i) define and locate areas where a threat to the environment is present and therefore an intervention is needed (i.e. in situ assessment and management); and ii) define sustainable and environmentally correct ways of managing sediments which are to be dredged for navigational purposes or in relation to other interventions (i.e., ex situ management). Materials and Methods: To examine how various regional and international SQGs 'classed' screening risk in Venice Lagoon sediments, data on median contaminant levels in surface sediments in Venice Lagoon resulting from a literature review were compared to a range of local and international sediment quality guidelines (SQGs). Then data on sediment contaminant levels in various areas and sub-basins of Venice Lagoon (main Lagoon, Porto Marghera and Venice City Canals) and in other regional and international transitional and coastal ecosystems with various levels of human impact (urbanization and industrialization) were evaluated based upon a selected consensus-based SQG. Finally, screening sediment quality for all of Venice Lagoon was mapped and contoured, relative to this consensus-based SQG and briefly compared with direct toxicity measurement through a battery of bioassays. Results: SQGs allow the sediment areas to be put in terms of potential, or screening, risk. Although there were some differences depending upon which specific SQGs were applied, the Venice SQGs and other international SQGs provided the same general picture of screening risk in Venice Lagoon despite geographic differences. Venice Lagoon South has the lowest screening risk levels, Venice Lagoon Central/North has the highest (and is nearest to the Porto Marghera and Venice City Canals sites). Discussion: The Venice

  6. Assessment of Adaptive Reuse of Heritage Shop Houses for Sleep Lodging in Malaysia: Fulfilment of Conservation Guidelines

    Directory of Open Access Journals (Sweden)

    Othuman Mydin M.A.

    2014-01-01

    Full Text Available This study focuses on the compliance of adaptive reuse of historic shop houses for sleep lodging with reference to the Guidelines for Conservation Areas and Heritage Buildings by Majlis Perbandaran Pulau Pinang (MPPP. Through this research, awareness towards the compliance of building conservation guidelines for heritage shop houses will be clarified accordingly. The goal of this study is to determine and extract vital clauses and components of Guidelines for Conservation Areas and Heritage Buildings (GCAHB towards adaptive reuse of heritage shop houses so that revitalization of these buildings can be ensured when changing the original function of the property. The aim is also to evaluate the compliance of the adaptive reuse of heritage shop houses with the GCAHB, and, lastly, to provide recommendations for adaptive reuse of heritage shop houses, also in compliance with the GCAHB. Additionally, heritage building owners can use this dissertation as a reference whenever they intend to adaptively reuse their buildings. Furthermore, recommendations in this research could be used for future reference.

  7. Linear quantification of lymphoid infiltration of the tumor margin: a reproducible method, developed with colorectal cancer tissues, for assessing a highly variable prognostic factor

    Directory of Open Access Journals (Sweden)

    Allard Marc-Antoine

    2012-11-01

    Full Text Available Abstract Background Lymphoid infiltration is a prognostic marker in solid tumors, such as colorectal, breast and lung carcinomas. However, lymphoid infiltration is heterogeneous and the reproducibility of quantification based on single counts within a tumor is very low. We aimed to develop a reproducible method for evaluating lymphoid infiltration in tumors. Methods Virtual slides were obtained from tissue sections from the localized colorectal carcinomas of 117 patients, stained for CD3 and CD45R0. We assessed the variation of lymphoid cell density by automatic counts in 1 mm-wide, 5 μm-long segments of the invasive front, along an axis 4 mm in length running perpendicular to the invasive front of the tumor. Results We plotted curves of the variation of lymphocyte density across the tumor front. Three distinct patterns emerged from this linear quantification of lymphocyte (LQLI. In pattern 1, there was a high density of lymphocytes within the tumor. In pattern 2, lymphocyte density peaked close to the invasive margin. In pattern 3, lymphocytes were diffusely distributed, at low density. It was possible to classify all the tumors studied, and interobserver reproducibility was excellent (kappa =0.9. By contrast, single counts of CD3+ cells on tissue microarrays were highly variable for a given LQLI pattern, confirming the heterogeneity of lymphoid infiltration within individual tumors. In univariate analysis, all pathologic features (stage, metastatic lymph node ratio (LNR, vascular embolism, perineural invasion, CD3+ cell density, LQLI patterns for CD3+ and CD45R0+ cells were found to have a significant effect on disease-free survival (DFS. In multivariate analysis, only the LQLI pattern for CD3+ cells (HR: 6.02; 95% CI: 2.74-13.18 and metastatic lymph node ratio (HR: 6.14; 95% CI: 2.32-16.2 were associated with DFS. Conclusion LQLI is an automated, reproducible method for the assessment of lymphoid infiltration. However, validation of its

  8. Clinical Practice Guidelines for Subarachnoid Haemorrhage Treatment

    OpenAIRE

    José Ramón Tejera del Valle; Danny Barrueta Reyes; Joaquín Aguilar Trujillo; José Gómez Cruz; Líder Tejera Sánchez

    2009-01-01

    Clinical Practice Guidelines for Subarachnoid Haemorrhage Treatment. The concept, diagnosis, classification and treatment are reviewed in its different stages, including aspects of the neurosurgical treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  9. Clinical Practice Guidelines for Intracranial Tumours Treatment

    OpenAIRE

    Danny Barrueta Reyes; Juan Guillermo Trigo Naranjo

    2009-01-01

    Clinical Practice Guidelines for Intracranial Tumours Treatment. We review the physiopathology, diagnosis (stressing screening studies) and treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  10. Dissolution test of herbal medicines containing Paullinia cupana: validation of methods for quantification and assessment of dissolution

    Directory of Open Access Journals (Sweden)

    Sandra Alves de Sousa

    2011-06-01

    Full Text Available "Guaraná" (Paullinia cupana is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three markers (caffeine, catechin and epicatechin, while 40% had only caffeine at tested dosage forms. In addition, after 30 minutes, only capsule A showed at least 80% of the dissolved markers. In other capsules, marker dissolution did not exceed 60% whereas 60% of the samples had some characteristic pharmacotechnical problems. These results evidence the need for rigorous quality control to help ensure the therapeutic action of these drugs. To this end, dissolution studies are an essential tool for quality assurance of herbal medicines.Guaraná (Paullinia cupana é utilizado como revigorante e estimulante devido à presença de metilxantinas e taninos condensados. Este trabalho visou avaliar o comportamento de dissolução de cinco fitoterápicos, na forma de cápsulas e comprimidos, contendo guaraná. O método de quantificação e de dissolução foram validados e os resultados obtidos permitiram a quantificação dos marcadores simultaneamente, com precisão, exatidão, seletividade e robustez. Foi verificado que 100% dos fitoterápicos analisados encontravam em desacordo quanto à presença dos quatro marcadores, sendo que 60% apresentaram três marcadores (cafeína, catequina e epicatequina e 40% apresentaram somente a cafeína. Além disso, após o tempo de 30 minutos de ensaio foi possível observar que somente a cápsula A apresentou pelo menos 80% dos

  11. Dual-phase dual-energy CT in patients with lung cancer: assessment of the additional value of iodine quantification in lymph node therapy response

    International Nuclear Information System (INIS)

    To investigate the potential contribution of iodine uptake calculation from dual-phase dual-energy CT (DE-CT) for lymph node staging and therapy response monitoring in lung cancer patients. Retrospective analysis of 27 patients with non-small cell lung carcinoma (NSCLC), who underwent dual-phase DE-CT before and after chemotherapy, was performed. Iodine uptake (mg/mL) and total iodine uptake (mg) were calculated using prototype software in the early (arterial) and late (venous) post-contrast circulatory phase in 110 mediastinal lymph nodes. The arterial enhancement fraction (AEF) was calculated and compared with lymph node size and response to chemotherapy. A significant difference of AEF was observed between enlarged (90.4 %; 32.3-238.5 %) and non-enlarged (72.7 %; -37.5-237.5 %) lymph nodes (p = 0.044) before treatment onset. A significantly different change of AEF in responding (decrease of 26.3 %; p = 0.022) and non-responding (increase of 43.0 %; p = 0.031) lymph nodes was demonstrated. A higher value of AEF before treatment was observed in lymph nodes with subsequent favourable response (88.6 % vs. 77.7 %; p = 0.122), but this difference did not reach statistical significance. The dual-phase DE-CT examination with quantification of ratio of early and late post-contrast iodine uptake is a feasible and promising method for the functional evaluation of mediastinal lymph nodes including therapy response assessment. (orig.)

  12. Dual-phase dual-energy CT in patients with lung cancer: assessment of the additional value of iodine quantification in lymph node therapy response

    Energy Technology Data Exchange (ETDEWEB)

    Baxa, Jan; Vondrakova, Alena; Matouskova, Tana; Ferda, Jiri [Charles University Teaching Hospital Plzen, Department of Imaging Methods, Plzen (Czech Republic); Ruzickova, Olga [Charles University Teaching Hospital Plzen, Department of Pulmonary Diseases, Plzen (Czech Republic); Schmidt, Bernhard; Flohr, Thomas; Sedlmair, Martin [Siemens Healthcare, CT Physics and Applications Development, Forchheim (Germany)

    2014-08-15

    To investigate the potential contribution of iodine uptake calculation from dual-phase dual-energy CT (DE-CT) for lymph node staging and therapy response monitoring in lung cancer patients. Retrospective analysis of 27 patients with non-small cell lung carcinoma (NSCLC), who underwent dual-phase DE-CT before and after chemotherapy, was performed. Iodine uptake (mg/mL) and total iodine uptake (mg) were calculated using prototype software in the early (arterial) and late (venous) post-contrast circulatory phase in 110 mediastinal lymph nodes. The arterial enhancement fraction (AEF) was calculated and compared with lymph node size and response to chemotherapy. A significant difference of AEF was observed between enlarged (90.4 %; 32.3-238.5 %) and non-enlarged (72.7 %; -37.5-237.5 %) lymph nodes (p = 0.044) before treatment onset. A significantly different change of AEF in responding (decrease of 26.3 %; p = 0.022) and non-responding (increase of 43.0 %; p = 0.031) lymph nodes was demonstrated. A higher value of AEF before treatment was observed in lymph nodes with subsequent favourable response (88.6 % vs. 77.7 %; p = 0.122), but this difference did not reach statistical significance. The dual-phase DE-CT examination with quantification of ratio of early and late post-contrast iodine uptake is a feasible and promising method for the functional evaluation of mediastinal lymph nodes including therapy response assessment. (orig.)

  13. Assessment and quantification of sources of variability in breast apparent diffusion coefficient (ADC) measurements at diffusion weighted imaging

    Energy Technology Data Exchange (ETDEWEB)

    Giannotti, E., E-mail: ytteb84@hotmail.com [Breast Imaging Department, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Waugh, S., E-mail: shelley.waugh@nhs.net [Department of Medical Physics, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Department of Clinical Radiology, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Priba, L., E-mail: lpriba@nhs.net [Department of Medical Physics, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Davis, Z., E-mail: zoedavis@doctors.org.uk [Breast Imaging Department, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Crowe, E., E-mail: e.crowe@nhs.net [Department of Clinical Radiology, Ninewells Hospital and Medical School, Dundee DD1 9SY (United Kingdom); Vinnicombe, S., E-mail: s.vinnicombe@dundee.ac.uk [Division of Imaging and Technology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY (United Kingdom)

    2015-09-15

    Highlights: • Inter-scan errors have minimal contribution to ADC measurement variability. • Intra-observer measures of ADC values in breast cancer are excellent. • ADC measures in whole tumour are more reproducible than minimum ADC measures. • ADC measurement error is most influenced by multiple readers. - Abstract: Purpose: Apparent Diffusion Coefficient (ADC) measurements are increasingly used for assessing breast cancer response to neoadjuvant chemotherapy although little data exists on ADC measurement reproducibility. The purpose of this work was to investigate and characterise the magnitude of errors in ADC measures that may be encountered in such follow-up studies- namely scanner stability, scan–scan reproducibility, inter- and intra- observer measures and the most reproducible measurement of ADC. Methods: Institutional Review Board approval was obtained for the prospective study of healthy volunteers and written consent acquired for the retrospective study of patient images. All scanning was performed on a 3.0-T MRI scanner. Scanner stability was assessed using an ice-water phantom weekly for 12 weeks. Inter-scan repeatability was assessed across two scans of 10 healthy volunteers (26–61 years; mean: 44.7 years). Inter- and intra-reader analysis repeatability was measured in 52 carcinomas from clinical patients (29–70 years; mean: 50.0 years) by measuring the whole tumor ADC value on a single slice with maximum tumor diameter (ADC{sub S}) and the ADC value of a small region of interest (ROI) on the same slice (ADC{sub min}). Repeatability was assessed using intraclass correlation coefficients (ICC) and coefficients of repeatability (CoR). Results: Scanner stability contributed 6% error to phantom ADC measurements (0.071 × 10{sup −3} mm{sup 2}/s; mean ADC = 1.089 × 10{sup −3} mm{sup 2}/s). The measured scan-scan CoR in the volunteers was 0.122 × 10{sup −3} mm{sup 2}/s, contributing an error of 8% to the mean measured values (ADC

  14. Assessment and quantification of sources of variability in breast apparent diffusion coefficient (ADC) measurements at diffusion weighted imaging

    International Nuclear Information System (INIS)

    Highlights: • Inter-scan errors have minimal contribution to ADC measurement variability. • Intra-observer measures of ADC values in breast cancer are excellent. • ADC measures in whole tumour are more reproducible than minimum ADC measures. • ADC measurement error is most influenced by multiple readers. - Abstract: Purpose: Apparent Diffusion Coefficient (ADC) measurements are increasingly used for assessing breast cancer response to neoadjuvant chemotherapy although little data exists on ADC measurement reproducibility. The purpose of this work was to investigate and characterise the magnitude of errors in ADC measures that may be encountered in such follow-up studies- namely scanner stability, scan–scan reproducibility, inter- and intra- observer measures and the most reproducible measurement of ADC. Methods: Institutional Review Board approval was obtained for the prospective study of healthy volunteers and written consent acquired for the retrospective study of patient images. All scanning was performed on a 3.0-T MRI scanner. Scanner stability was assessed using an ice-water phantom weekly for 12 weeks. Inter-scan repeatability was assessed across two scans of 10 healthy volunteers (26–61 years; mean: 44.7 years). Inter- and intra-reader analysis repeatability was measured in 52 carcinomas from clinical patients (29–70 years; mean: 50.0 years) by measuring the whole tumor ADC value on a single slice with maximum tumor diameter (ADCS) and the ADC value of a small region of interest (ROI) on the same slice (ADCmin). Repeatability was assessed using intraclass correlation coefficients (ICC) and coefficients of repeatability (CoR). Results: Scanner stability contributed 6% error to phantom ADC measurements (0.071 × 10−3 mm2/s; mean ADC = 1.089 × 10−3 mm2/s). The measured scan-scan CoR in the volunteers was 0.122 × 10−3 mm2/s, contributing an error of 8% to the mean measured values (ADCscan1 = 1.529 × 10−3 mm2/s; ADCscan2 = 1.507 × 10

  15. The Qiagen Investigator® Quantiplex HYres as an alternative kit for DNA quantification.

    Science.gov (United States)

    Frégeau, Chantal J; Laurin, Nancy

    2015-05-01

    The Investigator® Quantiplex HYres kit was evaluated as a potential replacement for dual DNA quantification of casework samples. This kit was determined to be highly sensitive with a limit of quantification and limit of detection of 0.0049ng/μL and 0.0003ng/μL, respectively, for both human and male DNA, using full or half reaction volumes. It was also accurate in assessing the amount of male DNA present in 96 mock and actual casework male:female mixtures (various ratios) processed in this exercise. The close correlation between the male/human DNA ratios expressed in percentages derived from the Investigator® Quantiplex HYres quantification results and the male DNA proportion calculated in mixed AmpFlSTR® Profiler® Plus or AmpFlSTR® Identifiler® Plus profiles, using the Amelogenin Y peak and STR loci, allowed guidelines to be developed to facilitate decisions regarding when to submit samples to Y-STR rather than autosomal STR profiling. The internal control (IC) target was shown to be more sensitive to inhibitors compared to the human and male DNA targets included in the Investigator® Quantiplex HYres kit serving as a good quality assessor of DNA extracts. The new kit met our criteria of enhanced sensitivity, accuracy, consistency, reliability and robustness for casework DNA quantification. PMID:25603128

  16. Baseline ecological risk assessment of the Calcasieu Estuary, Louisiana: 2. An evaluation of the predictive ability of effects-based sediment quality guidelines

    Science.gov (United States)

    MacDonald, Donald D.; Ingersoll, Christopher G.; Smorong, Dawn E.; Sinclair, Jesse A.; Lindskoog, Rebekka; Wang, Ning; Severn, Corrine; Gouguet, Ron; Meyer, John; Field, Jay

    2011-01-01

    Three sets of effects-based sediment-quality guidelines (SQGs) were evaluated to support the selection of sediment-quality benchmarks for assessing risks to benthic invertebrates in the Calcasieu Estuary, Louisiana. These SQGs included probable effect concentrations (PECs), effects range median values (ERMs), and logistic regression model (LRMs)-based T50 values. The results of this investigation indicate that all three sets of SQGs tend to underestimate sediment toxicity in the Calcasieu Estuary (i.e., relative to the national data sets), as evaluated using the results of 10-day toxicity tests with the amphipod, Hyalella azteca, or Ampelisca abdita, and 28-day whole-sediment toxicity tests with the H. azteca. These results emphasize the importance of deriving site-specific toxicity thresholds for assessing risks to benthic invertebrates.

  17. A practical approach for linearity assessment of calibration curves under the International Union of Pure and Applied Chemistry (IUPAC) guidelines for an in-house validation of method of analysis.

    Science.gov (United States)

    Sanagi, M Marsin; Nasir, Zalilah; Ling, Susie Lu; Hermawan, Dadan; Ibrahim, Wan Aini Wan; Naim, Ahmedy Abu

    2010-01-01

    Linearity assessment as required in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by a laboratory chemist in assessing linearity. Thus, this work proposes a simple method for linearity assessment in method validation by a regression analysis that covers experimental design, estimation of the parameters, outlier treatment, and evaluation of the assumptions according to the International Union of Pure and Applied Chemistry guidelines. The suitability of this procedure was demonstrated by its application to an in-house validation for the determination of plasticizers in plastic food packaging by GC. PMID:20922968

  18. A GIS-based vulnerability assessment tool for the quantification of natural risk in mountain and coastal areas

    Science.gov (United States)

    Puissant, A.; Schlosser, A.; Gazo, A.; -P., Malet J.; Lissak, C.; Goutiere, M.; Peltier, A.; Houet, T.

    2015-04-01

    Decision-makers need friendly tools for estimating natural risk for different future scenarios and for designing risk reduction strategies. In this work, a flexible GIS-based tool is presented in order to estimate vulnerability indicators (physical, economical, social) over territories of different size and at different scales. The tool has been designed in order to meet the requests of several categories of users (e.g. risk managers, decision planners, scientists). The tool is dedicated to the assessment of the vulnerability from several natural hazards (rock fall, landslide, flood, coastal erosion). On the basis of a database on the elements at risk, the user first selects the analysis scale (micro at the scale of the element at risk; meso at the scale of the municipality; macro at the scale of the catchment). Then, the calculation of vulnerability indicators is performed from this selection. The functionalities of the tool will be presented, and example of vulnerability indicators for some communities exposed will be discussed. The tool is developed within the ANR Project SAMCO.

  19. Quality assessment of raw and processed Arctium lappa L. through multicomponent quantification, chromatographic fingerprint, and related chemometric analysis.

    Science.gov (United States)

    Qin, Kunming; Wang, Bin; Li, Weidong; Cai, Hao; Chen, Danni; Liu, Xiao; Yin, Fangzhou; Cai, Baochang

    2015-05-01

    In traditional Chinese medicine, raw and processed herbs are used to treat different diseases. Suitable quality assessment methods are crucial for the discrimination between raw and processed herbs. The dried fruit of Arctium lappa L. and their processed products are widely used in traditional Chinese medicine, yet their therapeutic effects are different. In this study, a novel strategy using high-performance liquid chromatography and diode array detection coupled with multivariate statistical analysis to rapidly explore raw and processed Arctium lappa L. was proposed and validated. Four main components in a total of 30 batches of raw and processed Fructus Arctii samples were analyzed, and ten characteristic peaks were identified in the fingerprint common pattern. Furthermore, similarity evaluation, principal component analysis, and hierachical cluster analysis were applied to demonstrate the distinction. The results suggested that the relative amounts of the chemical components of raw and processed Fructus Arctii samples are different. This new method has been successfully applied to detect the raw and processed Fructus Arctii in marketed herbal medicinal products. PMID:25678337

  20. The role of skin conductivity in a low frequency exposure assessment for peripheral nerve tissue according to the ICNIRP 2010 guidelines

    Science.gov (United States)

    Schmid, Gernot; Cecil, Stefan; Überbacher, Richard

    2013-07-01

    Based on numerical computations using commercially available finite difference time domain code and a state-of-the art anatomical model of a 5-year old child, the influence of skin conductivity on the induced electric field strength inside the tissue for homogeneous front-to-back magnetic field exposure and homogeneous vertical electric field exposure was computed. Both ungrounded as well as grounded conditions of the body model were considered. For electric field strengths induced inside CNS tissue the impact of skin conductivity was found to be less than 15%. However, the results demonstrated that the use of skin conductivity values as obtainable from the most widely used data base of dielectric tissue properties and recommended by safety standards are not suitable for exposure assessment with respect to peripheral nerve tissue according to the ICNIRP 2010 guidelines in which the use of the induced electric field strengths inside the skin is suggested as a conservative surrogate for peripheral nerve exposure. This is due to the fact that the skin conductivity values derived from these data bases refer to the stratum corneum, the uppermost layer of the skin, which does not contain any nerve or receptor cells to be protected from stimulation effects. Using these skin conductivity values which are approximately a factor 250-500 lower than skin conductivity values used in studies on which the ICNIRP 2010 guidelines are based on, may lead to overestimations of the induced electric field strengths inside the skin by substantially more than a factor of 10. However, reliable conductivity data of deeper skin layers where nerve and preceptor cells are located is very limited. It is therefore recommended to include appropriate background information in the ICNIRP guidelines and the dielectric tissue property databases, and to put some emphasis on a detailed layer-specific characterization of skin conductivity in near future.

  1. The role of skin conductivity in a low frequency exposure assessment for peripheral nerve tissue according to the ICNIRP 2010 guidelines

    International Nuclear Information System (INIS)

    Based on numerical computations using commercially available finite difference time domain code and a state-of-the art anatomical model of a 5-year old child, the influence of skin conductivity on the induced electric field strength inside the tissue for homogeneous front-to-back magnetic field exposure and homogeneous vertical electric field exposure was computed. Both ungrounded as well as grounded conditions of the body model were considered. For electric field strengths induced inside CNS tissue the impact of skin conductivity was found to be less than 15%. However, the results demonstrated that the use of skin conductivity values as obtainable from the most widely used data base of dielectric tissue properties and recommended by safety standards are not suitable for exposure assessment with respect to peripheral nerve tissue according to the ICNIRP 2010 guidelines in which the use of the induced electric field strengths inside the skin is suggested as a conservative surrogate for peripheral nerve exposure. This is due to the fact that the skin conductivity values derived from these data bases refer to the stratum corneum, the uppermost layer of the skin, which does not contain any nerve or receptor cells to be protected from stimulation effects. Using these skin conductivity values which are approximately a factor 250–500 lower than skin conductivity values used in studies on which the ICNIRP 2010 guidelines are based on, may lead to overestimations of the induced electric field strengths inside the skin by substantially more than a factor of 10. However, reliable conductivity data of deeper skin layers where nerve and preceptor cells are located is very limited. It is therefore recommended to include appropriate background information in the ICNIRP guidelines and the dielectric tissue property databases, and to put some emphasis on a detailed layer-specific characterization of skin conductivity in near future. (paper)

  2. Assessment of coastal erosion and quantification of land loss on Western Pacific atolls during the last 50 years

    Science.gov (United States)

    Taborosi, Danko; Zega, Mojca; Jenson, John W.

    2010-05-01

    The majority of islands in the tropical western Pacific are coral atolls. Most are inhabited by indigenous Micronesian populations. Local people have over the millennia developed coping strategies and response mechanisms to difficult natural conditions, including typhoons, erosion, giant swells, and flooding, as well as ensuing famines and epidemics. However, since 1990s residents of atolls in the region have been appealing for help. They indicate that their islands are being rapidly eroded along coastlines, land areas are becoming smaller, and taro patches and other vegetation are being damaged. Such concerns were corroborated by one sweeping assessment by South Pacific Applied Geoscience Commission in 1998, as well as various isolated field observations since. Evidence of recent coastal erosion is found locally on many islands, both on windward and leeward sides and ocean and lagoon facing shores. Examples include retreating modern beaches, exhumed beachrock, scouring and undercutting of vegetation, overhanging scarps, etc. In addition, a considerable number of uninhabited islets have been completely obliterated by storms in the recent past; unusually high tides and swells have swept over large populated islands, destroying homes and harming agriculture; and at least one atoll has been abandoned due to irrecoverable typhoon damage. Those problems have received much worldwide media coverage, in which they are generally presented as "sinking" of islands due to global climate change and accompanying sea level rise. In reality, modern atolls are now known to be artifacts of the Pacific mid-Holocene High-Stand, and no first-hand data are available from Pacific islands to discern what proportion of observed erosional phenomena are 1) due to local natural and anthropogenic coastal processes as opposed to global and regional changes, and 2) caused by continuous natural dynamics as opposed to episodic extreme events. It is clear that some islands are faring better than

  3. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2016-06-01

    Full Text Available AUTHOR GUIDELINES Indian Journal of Community Health (IJCH accepts only online submission of manuscript(s by using Open Journal software (OJS at http://www.iapsmupuk.org/journal/index.php/IJCH/login Online SubmissionsAlready have a Username/Password for Indian Journal of Community Health (IJCH? GO TO LOGINNeed a Username/Password?GO TO REGISTRATIONNote: Registration and login are required to submit items online and to track the status of current submissions.Author GuidelinesIJCH strictly adheres on the recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals as per the standard universal guidelines given by International Committee of Medical Journal Editors (ICMJE - Recommendations for Uniform Requirements for Manuscripts. Authors are requested to visit http://www.icmje.org/index.html before making online submission of their manuscript(s. http://www.icmje.org/recommendations/browse/manuscript-preparation/preparing-for-submission.html Preparing for SubmissionGeneral PrinciplesReporting GuidelinesManuscript SectionsTitle PageAbstractIntroductionMethodsResultsDiscussionReferencesTablesIllustrations (FiguresUnits of MeasurementAbbreviations and Symbols 1. General PrinciplesThe text of articles reporting original research is usually divided into Introduction, Methods, Results, and Discussion sections. This so-called “IMRAD” structure is not an arbitrary publication format but a reflection of the process of scientific discovery. Articles often need subheadings within these sections to further organize their content. Other types of articles, such as meta-analyses, may require different formats, while case reports, narrative reviews, and editorials may have less structured or unstructured formats.Electronic formats have created opportunities for adding details or sections, layering information, cross-linking, or extracting portions of articles in electronic versions. Supplementary electronic

  4. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2015-12-01

    Full Text Available Author GuidelinesIJCH strictly adheres on the recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals as per the standard universal guidelines given by International Committee of Medical Journal Editors (ICMJE - Recommendations for Uniform Requirements for Manuscripts. Authors are requested to visit http://www.icmje.org/index.html before making online submission of their manuscript(s.  http://www.icmje.org/recommendations/browse/manuscript-preparation/preparing-for-submission.html Preparing for SubmissionPAGE CONTENTSGeneral PrinciplesReporting GuidelinesManuscript SectionsTitle PageAbstractIntroductionMethodsResultsDiscussionReferencesTablesIllustrations (FiguresUnits of MeasurementAbbreviations and Symbols1. General PrinciplesThe text of articles reporting original research is usually divided into Introduction, Methods, Results, and Discussion sections. This so-called “IMRAD” structure is not an arbitrary publication format but a reflection of the process of scientific discovery. Articles often need subheadings within these sections to further organize their content. Other types of articles, such as meta-analyses, may require different formats, while case reports, narrative reviews, and editorials may have less structured or unstructured formats.Electronic formats have created opportunities for adding details or sections, layering information, cross-linking, or extracting portions of articles in electronic versions. Supplementary electronic-only material should be submitted and sent for peer review simultaneously with the primary manuscript.2. Reporting GuidelinesReporting guidelines have been developed for different study designs; examples include CONSORT for randomized trials, STROBE for observational studies, PRISMA for systematic reviews and meta-analyses, and STARD for studies of diagnostic accuracy. Journals are encouraged to ask authors to follow these guidelines because

  5. Implementation of World Health Organization Integrated Management of Childhood Illnesses (IMCI Guidelines for the Assessment of Pneumonia in the Under 5s in Rural Malawi.

    Directory of Open Access Journals (Sweden)

    Ngozi Kalu

    Full Text Available The Cooking and Pneumonia Study (CAPS is a pragmatic cluster-level randomized controlled trial of the effect of an advanced cookstove intervention on pneumonia in children under the age of 5 years (under 5s in Malawi (www.capstudy.org. The primary outcome of the trial is the incidence of pneumonia during a two-year follow-up period, as diagnosed by healthcare providers who are using the World Health Organization (WHO integrated management of childhood illnesses (IMCI pneumonia assessment protocol and who are blinded to the trial arms. We evaluated the quality of pneumonia assessment in under 5s in this setting via a cross-sectional study of provider-patient encounters at nine outpatient clinics located within the catchment area of 150 village-level clusters enrolled in the trial across the two study locations of Chikhwawa and Karonga, Malawi, between May and June 2015 using the IMCI guidelines as a benchmark. Data were collected using a key equipment checklist, an IMCI pneumonia knowledge test, and a clinical evaluation checklist. The median number of key equipment items available was 6 (range 4 to 7 out of a possible 7. The median score on the IMCI pneumonia knowledge test among 23 clinicians was 75% (range 60% to 89%. Among a total of 176 consultations performed by 15 clinicians, a median of 9 (range 3 to 13 out of 13 clinical evaluation tasks were performed. Overall, the clinicians were adequately equipped for the assessment of sick children, had good knowledge of the IMCI guidelines, and conducted largely thorough clinical evaluations. We recommend the simple pragmatic approach to quality assurance described herein for similar studies conducted in challenging research settings.

  6. Implementation of World Health Organization Integrated Management of Childhood Illnesses (IMCI) Guidelines for the Assessment of Pneumonia in the Under 5s in Rural Malawi.

    Science.gov (United States)

    Kalu, Ngozi; Lufesi, Norman; Havens, Deborah; Mortimer, Kevin

    2016-01-01

    The Cooking and Pneumonia Study (CAPS) is a pragmatic cluster-level randomized controlled trial of the effect of an advanced cookstove intervention on pneumonia in children under the age of 5 years (under 5s) in Malawi (www.capstudy.org). The primary outcome of the trial is the incidence of pneumonia during a two-year follow-up period, as diagnosed by healthcare providers who are using the World Health Organization (WHO) integrated management of childhood illnesses (IMCI) pneumonia assessment protocol and who are blinded to the trial arms. We evaluated the quality of pneumonia assessment in under 5s in this setting via a cross-sectional study of provider-patient encounters at nine outpatient clinics located within the catchment area of 150 village-level clusters enrolled in the trial across the two study locations of Chikhwawa and Karonga, Malawi, between May and June 2015 using the IMCI guidelines as a benchmark. Data were collected using a key equipment checklist, an IMCI pneumonia knowledge test, and a clinical evaluation checklist. The median number of key equipment items available was 6 (range 4 to 7) out of a possible 7. The median score on the IMCI pneumonia knowledge test among 23 clinicians was 75% (range 60% to 89%). Among a total of 176 consultations performed by 15 clinicians, a median of 9 (range 3 to 13) out of 13 clinical evaluation tasks were performed. Overall, the clinicians were adequately equipped for the assessment of sick children, had good knowledge of the IMCI guidelines, and conducted largely thorough clinical evaluations. We recommend the simple pragmatic approach to quality assurance described herein for similar studies conducted in challenging research settings. PMID:27187773

  7. Quantification of myocardial perfusion SPECT for the assessment of coronary artery disease: should we apply scatter correction?

    International Nuclear Information System (INIS)

    Compared to other non invasive testings for CAD diagnosis, myocardial perfusion imaging (MPI) is considered as a very sensitive method which accuracy is however often dimmed by a certain lack of specificity, especially in patients with a small heart. With gated SPECT MPI, use of end-diastolic instead of summed images has been presented as an interesting approach for increasing specificity. Since scatter correction is reported to improve image contrast, it might potentially constitute another way to ameliorate MPI accuracy. We aimed at comparing the value of both approaches, either separate or combined, for CAD diagnosis. Methods. Hundred patients addressed for gated 99m-Tc sestamibi SPECT MPI were prospectively included (Group A). Thirty-five had an end-systolic volume <30ml by QGS-analysis (Group B). All had a coronary angiogram within 3 months of the MPI. Four polar maps (non-corrected and scatter-corrected summed, and non-corrected and scatter-corrected end-diastolic) were created to quantify the extent (EXT) and severity (TDS) of the perfusion defects if any. ROC-curve analysis was applied to define the optimal thresholds of EXT and TDS separating non-CAD from CAD-patients, using a 50%-stenosis on coronary angiogram as cutoff for disease positivity. Results. Significant CAD was present in 86 patients (25 in Group B). In Group A, assessment of EXT and TDS of perfusion defects on scatter-corrected summed images demonstrated the highest accuracy (76% for EXT; sens: 77%; spec: 71%, and 74% for TDS, sens: 73%, spec: 79%). Accuracy of EXT and TDS calculated from the other data sets was slightly but not significantly lower, especially because of a lower sensitivity. As a comparison, visual analysis was 90% accurate for the diagnosis of CAD (sens: 94%, spec: 64%). In group B, overall results were worse mainly due to a decreased sensitivity, with accuracies ranging between 51 and 63%. Again scatter-corrected summed data were the most accurate (EXT: 60%, TDS: 63%, visual

  8. Dietary guidelines

    DEFF Research Database (Denmark)

    Jelsøe, Erling

    2015-01-01

    in a number of countries have addressed the issue of making dietary guidelines that integrate health and sustainability, but in all cases they have been met with different kinds of resistance. This article reviews the development towards an integrated understanding of health and sustainability in...... relation to food and eating and the emergence of proposals for integrated guidelines. It explores the conflicts and controversies that have arisen in the wake of the various proposals and identifies a number of different types of conflicts. These relate to conflicts of interests between the various actors...... involved and political resistance against initiatives that are perceived as being in conflict with the values of a market economy and free trade. Furthermore, there are controversies that can be broadly characterised as relating to the politics of knowledge and have to do with the differentiation of...

  9. Guidelines for the Review of Research Reactor Safety: Revised Edition. Reference Document for IAEA Integrated Safety Assessment of Research Reactors (INSARR)

    International Nuclear Information System (INIS)

    The Integrated Safety Assessment of Research Reactors (INSARR) is an IAEA safety review service available to Member States with the objective of supporting them in ensuring and enhancing the safety of their research reactors. This service consists of performing a comprehensive peer review and an assessment of the safety of the respective research reactor. The reviews are based on IAEA safety standards and on the provisions of the Code of Conduct on the Safety of Research Reactors. The INSARR can benefit both the operating organizations and the regulatory bodies of the requesting Member States, and can include new research reactors under design or operating research reactors, including those which are under a Project and Supply Agreement with the IAEA. The first IAEA safety evaluation of a research reactor operated by a Member State was completed in October 1959 and involved the Swiss 20 MW DIORIT research reactor. Since then, and in accordance with its programme on research reactor safety, the IAEA has conducted safety review missions in its Member States to enhance the safety of their research reactor facilities through the application of the Code of Conduct on the Safety of Research Reactors and the relevant IAEA safety standards. About 320 missions in 51 Member States were undertaken between 1972 and 2012. The INSARR missions and other limited scope safety review missions are conducted following the guidelines presented in this publication, which is a revision of Guidelines for the Review of Research Reactor Safety (IAEA Services Series No. 1), published in December 1997. This publication details those IAEA safety standards and guidance publications relevant to the safety of research reactors that have been revised or published since 1997. The purpose of this publication is to give guidance on the preparation, implementation, reporting and follow-up of safety review missions. It is also intended to be of assistance to operators and regulators in conducting

  10. Author guidelines

    OpenAIRE

    Chief Editor

    2014-01-01

    AUTHOR GUIDELINESIndian Journal of Community Health (IJCH) accepts only online submission of manuscript(s) by using Open Journal software (OJS) at http://www.iapsmupuk.org/journal/index.php/IJCH/loginOnline SubmissionsAlready have a Username/Password for Indian Journal of Community Health (IJCH)? GO TO LOGINNeed a Username/Password?GO TO REGISTRATIONNote: Registration and login are required to submit items online and to track the status of current submissions.Author GuidelinesIJCH strictly ad...

  11. Assessment of real-time PCR based methods for quantification of pollen-mediated gene flow from GM to conventional maize in a field study.

    Science.gov (United States)

    Pla, Maria; La Paz, José-Luis; Peñas, Gisela; García, Nora; Palaudelmàs, Montserrat; Esteve, Teresa; Messeguer, Joaquima; Melé, Enric

    2006-04-01

    Maize is one of the main crops worldwide and an increasing number of genetically modified (GM) maize varieties are cultivated and commercialized in many countries in parallel to conventional crops. Given the labeling rules established e.g. in the European Union and the necessary coexistence between GM and non-GM crops, it is important to determine the extent of pollen dissemination from transgenic maize to other cultivars under field conditions. The most widely used methods for quantitative detection of GMO are based on real-time PCR, which implies the results are expressed in genome percentages (in contrast to seed or grain percentages). Our objective was to assess the accuracy of real-time PCR based assays to accurately quantify the contents of transgenic grains in non-GM fields in comparison with the real cross-fertilization rate as determined by phenotypical analysis. We performed this study in a region where both GM and conventional maize are normally cultivated and used the predominant transgenic maize Mon810 in combination with a conventional maize variety which displays the characteristic of white grains (therefore allowing cross-pollination quantification as percentage of yellow grains). Our results indicated an excellent correlation between real-time PCR results and number of cross-fertilized grains at Mon810 levels of 0.1-10%. In contrast, Mon810 percentage estimated by weight of grains produced less accurate results. Finally, we present and discuss the pattern of pollen-mediated gene flow from GM to conventional maize in an example case under field conditions. PMID:16604462

  12. Quantification of emissions from domestic heating in residential areas of İzmir, Turkey and assessment of the impact on local/regional air-quality

    International Nuclear Information System (INIS)

    Air pollution in cities is a major environmental problem principally in the developing countries. The quantification of emissions is a basic requirement to assess the human influence to the atmosphere. The air quality generally shows decreases with the major contribution residential emissions and meteorology in the winter season in the big cities. Poor meteorological conditions especially inversion events for the efficient mixing of air pollutants occurred during the winter months in İzmir. With this work we quantify the amount of domestic heating emissions for particulate matter (PM10), sulfur dioxides (SO2), nitrogen dioxides (NO2), volatile organic compounds (VOC) and carbon monoxide (CO) together with greenhouse gases which are carbon dioxide (CO2), nitrous oxide (N2O) and methane (CH4) in İzmir for 2008–2009 winter season. The results showed that the most affected residential areas were central districts in the city center from domestic heating emissions due to meteorological condition and demographic reasons. Air quality modeling is a great tool for assisting policy makers how to decrease emissions and improve air quality. At the second part of the study, calculated emissions were modeled by using CALMET/CALPUFF dispersion modeling system and plotted in the form of air pollution maps by using geographical information system to determine the locations and estimate the effects of the new residential areas that will be established in the future in İzmir. - Highlights: • The air pollution in cities especially shows raises with the opening of winter season. • Air pollution has become a problem due to rapid urbanization in İzmir, Turkey. • The air quality shows decreases with the residential emissions in İzmir's winter. • With this work we quantify the amount of domestic heating emissions for pollutants. • The impact of emissions on local air-quality is determined by using dispersion model

  13. Improving the application of a practice guideline for the assessment and treatment of suicidal behavior by training the full staff of psychiatric departments via an e-learning supported Train-the-Trainer program : study protocol for a randomized controlled trial

    NARCIS (Netherlands)

    de Beurs, Derek P.; de Groot, Marieke H.; de Keijser, Jos; Verwey, Bastiaan; Mokkenstorm, Jan; Twisk, Jos W. R.; van Duijn, Erik; van Hemert, Albert M.; Verlinde, Lia; Spijker, Jan; van Luijn, Bert; Vink, Jan; Kerkhof, Ad J. F. M.

    2013-01-01

    Background: In 2012, in The Netherlands a multidisciplinary practice guideline for the assessment and treatment of suicidal behavior was issued. The release of guidelines often fails to change professional behavior due to multiple barriers. Structured implementation may improve adherence to guidelin

  14. Improving the application of a practice guideline for the assessment and treatment of suicidal behavior by training the full staff of psychiatric departments via an e-learning supported Train-the-Trainer program: study protocol for a randomized controlled trial

    NARCIS (Netherlands)

    Beurs, D.P. de; Groot, M.H. de; Keijser, J. de; Verwey, B.; Mokkenstorm, J.; Twisk, J.W.R.; Duijn, E. van; Hemert, A.M. van; Verlinde, L.; Spijker, J.; Luijn, B. van; Vink, J.; Kerkhof, A.J.

    2013-01-01

    BACKGROUND: In 2012, in The Netherlands a multidisciplinary practice guideline for the assessment and treatment of suicidal behavior was issued. The release of guidelines often fails to change professional behavior due to multiple barriers. Structured implementation may improve adherence to guidelin

  15. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: Update. Consensus SEMICYUC-SENPE: Nutritional assessment

    Directory of Open Access Journals (Sweden)

    S. Ruiz-Santana

    2011-11-01

    Full Text Available Current parameters to assess nutritional status in critically-ill patients are useful to evaluate nutritional status prior to admission to the intensive care unit. However, these parameters are of little utility once the patient's nutritional status has been altered by the acute process and its treatment. Changes in water distribution affect anthropometric variables and biochemical biomarkers, which in turn are affected by synthesis and degradation processes. Increased plasma levels of prealbumin and retinol -proteins with a short half-life- can indicate adequate response to nutritional support, while reduced levels of these proteins indicate further metabolic stress. The parameters used in functional assessment, such as those employed to assess muscular or immune function, are often altered by drugs or the presence of infection or polyneuropathy. However, some parameters can be used to monitor metabolic response and refeeding or can aid prognostic evaluation.

  16. Systematic review on tuberculosis transmission on aircraft and update of the European Centre for Disease Prevention and Control risk assessment guidelines for tuberculosis transmitted on aircraft (RAGIDA-TB).

    Science.gov (United States)

    Kotila, Saara M; Payne Hallström, Lara; Jansen, Niesje; Helbling, Peter; Abubakar, Ibrahim

    2016-01-01

    As a setting for potential tuberculosis (TB) transmission and contact tracing, aircraft pose specific challenges. Evidence-based guidelines are needed to support the related-risk assessment and contact-tracing efforts. In this study evidence of TB transmission on aircraft was identified to update the Risk Assessment Guidelines for TB Transmitted on Aircraft (RAGIDA-TB) of the European Centre for Disease Prevention and Control (ECDC). Electronic searches were undertaken from Medline (Pubmed), Embase and Cochrane Library until 19 July 2013. Eligible records were identified by a two-stage screening process and data on flight and index case characteristics as well as contact tracing strategies extracted. The systematic literature review retrieved 21 records. Ten of these records were available only after the previous version of the RAGIDA guidelines (2009) and World Health Organization guidelines on TB and air travel (2008) were published. Seven of the 21 records presented some evidence of possible in-flight transmission, but only one record provided substantial evidence of TB transmission on an aircraft. The data indicate that overall risk of TB transmission on aircraft is very low. The updated ECDC guidelines for TB transmission on aircraft have global implications due to inevitable need for international collaboration in contract tracing and risk assessment. PMID:26848520

  17. Interview: European collaboration in relative effectiveness assessment: the use of patient registries and development of common guidelines.

    Science.gov (United States)

    Goettsch, Wim

    2013-07-01

    Wim Goettsch is currently the Project Leader of Work Package 5 of the European Network of Health Technology Assessment (EUnetHTA) Joint Action 2 (2012-2015). EUnetHTA is a network of the health technology assessment organizations in Europe responsible for advising or deciding on the national reimbursement of pharmaceuticals and other health technologies. In this work package, rapid joint assessments of the relative effectiveness of pharmaceuticals are piloted between more than 25 health technology assessment organizations around Europe. These pilots are based on the methodology that was developed in a similar work package in EUnetHTA JA1 (2010-2012), of which Dr Goettsch was also the Project Leader. Until the beginning of 2013, Dr Goettsch was the Deputy Secretary of the Medicinal Products Reimbursement Committee at Dutch Healthcare Insurance Board (CVZ). The Dutch Medicinal Products Reimbursement Committee advises the Dutch Minister of Health on whether new drugs need to be included in the basic insurance package. Before joining CVZ, he worked as a research manager for the PHARMO Institute (Utrecht, The Netherlands) and was responsible for the coordination of numerous pharmacoepidemiological and outcomes studies for international offices of pharmaceutical companies, such as AstraZeneca, Novartis, Pfizer and GlaxoSmithKline. Dr Goettsch has approximately 50 publications in peer-reviewed international journals. PMID:24236677

  18. ASSET guidelines. Revised 1991 Edition

    International Nuclear Information System (INIS)

    The present publication is an updated version of the IAEA Assessment of Safety Significant Events Team (ASSET) Guidelines, IAEA-TECDOC-573, published in 1990. Sections 5 and 6 include revised definitions and investigation guidelines for identification of both direct and root causes. These revisions were recommended by a Consultants Meeting held in Vienna on 3-7 December 1990. This guidance is not intended to infringe an expert's prerogative to investigate additional items. Its main purpose is to provide a basic structure and ensure consistency in the assessments. Use of the ASSET guidelines should also facilitate comparison between the observations made in different nuclear power plants and harmonize the reporting of generic ASSET results. The guidelines should always be used with a critical attitude and a view to possible improvements

  19. The development and assessment of high-throughput mass spectrometry-based methods for the quantification of a nanoparticle drug delivery agent in cellular lysate.

    Science.gov (United States)

    Buse, Joshua; Purves, Randy W; Verrall, Ronald E; Badea, Ildiko; Zhang, Haixia; Mulligan, Christopher C; Peru, Kerry M; Bailey, Jonathan; Headley, John V; El-Aneed, Anas

    2014-11-01

    The safe use of lipid-based drug delivery agents requires fast and sensitive qualitative and quantitative assessment of their cellular interactions. Many mass spectrometry (MS) based analytical platforms can achieve such task with varying capabilities. Therefore, four novel high-throughput MS-based quantitative methods were evaluated for the analysis of a small organic gene delivery agent: N,N-bis(dimethylhexadecyl)-1,3-propane-diammonium dibromide (G16-3). Analysis utilized MS instruments that detect analytes using low-resolution tandem MS (MS/MS) analysis (i.e. QTRAP or linear ion trap in this work) or high-resolution MS analysis (i.e. time of flight (ToF) or Orbitrap). Our results indicate that the validated fast chromatography (FC)-QTRAP-MS/MS, FC- LTQ-Orbitrap-MS, desorption electrospray ionization-collision-induced dissociation (CID)-MS/MS and matrix assisted laser desorption ionization-ToF/ToF-MS MS methods were superior in the area of method development and sample analysis time to a previously developed liquid chromatography (LC)-CID-MS/MS. To our knowledge, this is the first evaluation of the abilities of five MS-based quantitative methods that target a single pharmaceutical analyte. Our findings indicate that, in comparison to conventional LC-CID-MS/MS, the new MS-based methods resulted in a (1) substantial reduction in the analysis time, (2) reduction in the time required for method development and (3) production of either superior or comparable quantitative data. The four new high-throughput MS methods, therefore, were faster, more efficient and less expensive than a conventional LC-CID-MS/MS for the quantification of the G16-3 analyte within tissue culture. When applied to cellular lysate, no significant change in the concentration of G16-3 gemini surfactant within PAM212 cells was observed between 5 and 53 h, suggesting the absence of any metabolism/excretion from PAM212 cells. PMID:25395133

  20. Lung involvement quantification in chest radiographs

    International Nuclear Information System (INIS)

    Tuberculosis (TB) caused by Mycobacterium tuberculosis, is an infectious disease which remains a global health problem. The chest radiography is the commonly method employed to assess the TB's evolution. The methods for quantification of abnormalities of chest are usually performed on CT scans (CT). This quantification is important to assess the TB evolution and treatment and comparing different treatments. However, precise quantification is not feasible for the amount of CT scans required. The purpose of this work is to develop a methodology for quantification of lung damage caused by TB through chest radiographs. It was developed an algorithm for computational processing of exams in Matlab, which creates a lungs' 3D representation, with compromised dilated regions inside. The quantification of lung lesions was also made for the same patients through CT scans. The measurements from the two methods were compared and resulting in strong correlation. Applying statistical Bland and Altman, all samples were within the limits of agreement, with a confidence interval of 95%. The results showed an average variation of around 13% between the two quantification methods. The results suggest the effectiveness and applicability of the method developed, providing better risk-benefit to the patient and cost-benefit ratio for the institution. (author)

  1. Buckling-driven delamination growth in composite laminates: Guidelines for assessing the threat posed by interlaminar matrix delamination

    DEFF Research Database (Denmark)

    Bhushan, Karihaloo; Stang, Henrik

    2008-01-01

    This paper is concerned with development of a simple procedure to assess the threat posed by interlaminar matrix delaminations to the integrity of composite laminates when they are situated in a compressive stress field. Depending upon the size of the delamination, its location below the surface...... and on the level of the applied stress, it may or may not buckle away from the rest of the laminate. If it buckles, the post-buckling response will depend upon the applied compressive stress level, the thickness of the delaminated ply and the interlaminar critical energy release rate of the composite...

  2. Reducing patients' suicide ideation through training mental health teams in the application of the Dutch multidisciplinary practice guideline on assessment and treatment of suicidal behavior : study protocol of a randomized controlled trial

    NARCIS (Netherlands)

    de Beurs, Derek P.; de Groot, Marieke H.; Bosmans, Judith E.; de Keijser, Jos; Mokkenstorm, Jan; Verwey, Bas; van Duijn, Erik; de Winter, Remco F. P.; Kerkhof, Ad J. F. M.

    2013-01-01

    Background: To strengthen suicide prevention skills in mental health care in The Netherlands, multidisciplinary teams throughout the country are trained in the application of the new Dutch guideline on the assessment and treatment of suicidal behavior. Previous studies have shown beneficial effects

  3. Guidelines for the review research reactor safety. Reference document for IAEA Integrated Safety Assessment of Research Reactors (INSARR)

    International Nuclear Information System (INIS)

    In 1992, the IAEA published new safety standards for research reactors as part of the set of publications considered by its Research Reactor Safety Programme (RRSP). This set also includes publications giving guidance for all safety aspects related to the lifetime of a research reactor. In addition, the IAEA has also revised the Safety Standards for radiation protection. Consequently, it was considered advisable to revise the Integrated Safety Assessment of Research Reactors (INSARR) procedures to incorporate the new requirements and guidance as well as to extend the scope of the safety reviews to currently operating research reactors. The present report is the result of this revision. The purpose of this report is to give guidance on the preparation, execution, reporting and follow-up of safety review mission to research reactors as conducted by the IAEA under its INSARR missions safety service. However, it will also be of assistance to operators and regulators in conducting: (a) ad hoc safety assessments of research reactors to address individual issues such as ageing or safety culture; and (b) other types of safety reviews such as internal and peer reviews and regulatory inspections

  4. Clinical Practice Guidelines for Critical Patients’ Nutrition.

    OpenAIRE

    Marta Patricia Casanova González; Roberto Travieso Peña; Félix Molina Díaz

    2009-01-01

    Clinical Practice Guidelines for Critical Patients’ Nutrition. This document includes a review and update of aspects related with nutritional assessment of patients in critical condition; indications, contraindications and procedures for enteral and parenteral nutrition and its follow up. It includes assessment guidelines focused on the most important aspects to be accomplished.

  5. D4.2 Guideline for Load and Resistance Assessment of Existing European Railway Bridges - Sustainable Bridges - Assessment for future traffic demands and longer lives

    OpenAIRE

    EUROPEAN COMMISSION

    2007-01-01

    The bridge assessment in many aspects is very similar to the bridge design. The same basic principles lie at the heart of the process. Nevertheless, an important difference lies in the fact when a bridge is being designed, an element of conservatism is generally a good thing that can be achieved with very little additional costs. When a bridge is being assessed, it is important to avoid unnecessarily conservative measures because of the financial implications that may follow the decision of r...

  6. IPERS guidelines for the international peer review service. Second edition. Procedures for conducting independent peer reviews of probabilistic safety assessments

    International Nuclear Information System (INIS)

    This publication describes the purposes and the objectives of an International Peer Review Service (IPERS) review. The main objective is first to assess whether important technological and methodological issues in the PSA are treated in an adequate manner and, second, whether specific conclusions and applications of the PSA are supported by the underlying technical analysis in an appropriate way. An important aspect for an IPERS review is the communication and exchange of views between the international experts carrying out the review and the members of the PSA team. This TECDOC is intended to give guidance on how an IPERS review is organized and conducted, it describes the steps needed to prepare the review and it highlights the PSA aspects which should be covered in detail. 30 refs, 1 fig., 2 tabs

  7. IRIS guidelines. 2014 ed. Integrated Review of Infrastructure for Safety (IRIS) for self-assessment when establishing the safety infrastructure for a nuclear power programme

    International Nuclear Information System (INIS)

    The IAEA safety standards reflect an international consensus on what constitutes a high level of safety for protecting people and the environment, and therefore represent what all Member States should achieve, whilst recognizing the ultimate responsibility of each State to ensure safety when implementing a nuclear power programme. IAEA Safety Standards Series No. SSG-16, entitled Establishing the Safety Infrastructure for a Nuclear Power Programme was published in order to provide recommendations, presented in the form of sequential actions, on meeting safety requirements progressively during the initial three phases of the development of safety, as described in INSAG-22, Nuclear Safety Infrastructure for a National Nuclear Power Programme Supported by the IAEA Fundamental Safety Principles. To that end, the 200 safety related actions, which are proposed by SSG-16, constitute a roadmap to establish a foundation for promoting a high level of safety over the entire lifetime of the nuclear power plant. These actions reflect international consensus on good practice in order to achieve full implementation of IAEA safety standards. The IAEA has developed a methodology and tool, the Integrated Review of Infrastructure for Safety (IRIS), to assist States in undertaking self-assessment with respect to SSG-16 recommendations when establishing the safety infrastructure for a nuclear power programme, and to develop an action plan for improvement. The IRIS methodology and the associated tool are fully compatible with the IAEA safety standards and are also used, when appropriate, in the preparation of review missions, such as the Integrated Regulatory Review Service and advisory missions. The present guidelines describe the IRIS methodology for self-assessment against SSG-16 recommendations. Through IRIS implementation, every organization concerned with nuclear safety may gain proper awareness and engage in a continuous progressive process to develop the effective national

  8. Real-time polymerase chain reaction-based approach for quantification of the pat gene in the T25 Zea mays event.

    Science.gov (United States)

    Weighardt, Florian; Barbati, Cristina; Paoletti, Claudia; Querci, Maddalena; Kay, Simon; De Beuckeleer, Marc; Van den Eede, Guy

    2004-01-01

    In Europe, a growing interest for reliable techniques for the quantification of genetically modified component(s) of food matrixes is arising from the need to comply with the European legislative framework on novel food products. Real-time polymerase chain reaction (PCR) is currently the most powerful technique for the quantification of specific nucleic acid sequences. Several real-time PCR methodologies based on different molecular principles have been developed for this purpose. The most frequently used approach in the field of genetically modified organism (GMO) quantification in food or feed samples is based on the 5'-3'-exonuclease activity of Taq DNA polymerase on specific degradation probes (TaqMan principle). A novel approach was developed for the establishment of a TaqMan quantification system assessing GMO contents around the 1% threshold stipulated under European Union (EU) legislation for the labeling of food products. The Zea mays T25 elite event was chosen as a model for the development of the novel GMO quantification approach. The most innovative aspect of the system is represented by the use of sequences cloned in plasmids as reference standards. In the field of GMO quantification, plasmids are an easy to use, cheap, and reliable alternative to Certified Reference Materials (CRMs), which are only available for a few of the GMOs authorized in Europe, have a relatively high production cost, and require further processing to be suitable for analysis. Strengths and weaknesses of the use of novel plasmid-based standards are addressed in detail. In addition, the quantification system was designed to avoid the use of a reference gene (e.g., a single copy, species-specific gene) as normalizer, i.e., to perform a GMO quantification based on an absolute instead of a relative measurement. In fact, experimental evidences show that the use of reference genes adds variability to the measurement system because a second independent real-time PCR-based measurement

  9. Guidelines for comparative assessment of the environmental impacts of wastes from electricity generation systems. A framework for the assessment and comparison of environmental impacts

    International Nuclear Information System (INIS)

    The report describes the initial phase of a project intended to provide guidance to those concerned with environmental aspects of solid and hazardous waste management in electrical energy production systems. The focus is on describing a methodology for assessing and comparing the environmental impact arising from these wastes, and thereby to provide an input to overall electrical generation comparison projects, such as DECADES. The structure of the report is as follows: after considering a range of electrical energy production systems with an outline discussion of the waste streams produced in each case, the relevant treatment technologies and disposal options are reviewed. Then the elements of the framework for comparative assessment proposed in this report are described. The types of environmental impact, environmental protection criteria and indicators or end-points to measure the impact, the way in which such impacts can be quantitatively assessed and compared are discussed. 59 refs, figs and tabs

  10. SARIS Guidelines. 2014 Ed

    International Nuclear Information System (INIS)

    The IAEA fundamental safety principles provide the basis for IAEA safety standards and IAEA related programmes. IAEA safety standards reflect an international consensus on what constitutes a high level of safety for protecting people and the environment, and therefore represent what all regulators should achieve. These standards, in particular IAEA Safety Standards Series No. GSR Part 1, Governmental, Legal and Regulatory Framework for Safety, provide the basics for establishing, maintaining and continuously improving the governmental, legal and regulatory framework for safety. Additional IAEA requirements and guidance, such as the IAEA Safety Standards Series No. GSR Part 3 (Interim), Radiation Protection and Safety of Radiation Sources: International Basic Safety Standards, and IAEA Safety Standards Series No. GS-R-3, The Management System for Facilities and Activities, are also used to establish and develop the national infrastructure for safety and for establishing and implementing a management system. Assessment of the regulatory framework for safety with respect to the IAEA safety standards can be made either through an external review or through internal self-assessment. Self-assessment offers a mechanism by which an organization can assess its performance against established standards and models and thereby identify areas for improvement. The IAEA has developed a methodology and tool for Self-assessment of the Regulatory Infrastructure for Safety (SARIS), to assist States in undertaking self-assessment of their national safety framework in accordance with the requirements and recommendations of the IAEA safety standards, and to develop an action plan for improvement. The IAEA self-assessment methodology and the associated tools are fully compatible with the IAEA safety standards and are also used in the preparation for regulatory review missions, such as the Integrated Regulatory Review Service and advisory missions. These guidelines have been developed to

  11. European Society of Cardiology 2009 guidelines for preoperative cardiac risk assessment and perioperative cardiac management in noncardiac surgery. Key messages for clinical practice

    Directory of Open Access Journals (Sweden)

    Sanne E. Hoeks

    2010-07-01

    Full Text Available Patients undergoing noncardiac surgery are at risk of adverse perioperative and long-term outcome. When considering a patient for noncardiac surgery, a careful preoperative clinical risk evaluation and subsequent risk-reduction strategies are essential to reduce postoperative complications. To assist physicians with decision making, clinical guidelines are developed. The aim of clinical guidelines is to improve patient care by providing recommendations about appropriate healthcare in specific circumstances. Development of clinical guidelines is an important component in improving the quality of care. By translating the best available scientific evidence into specific recommendations, guidelines can serve as a useful tool to achieve effective and efficient patient care. In 2009, the first European Society of Cardiology guidelines on perioperative care were developed. This decisionmaking process integrates clinical markers, early coronary evaluation, functional capacity, and the type of surgery involved.

  12. Quantification of micronuclei in blood lymphocytes of patients exposed to gamma radiation for dose absorbed assessment; Quantificacao de micronucleos em linfocitos de pacientes expostas a radiacao gama para a avaliacao da dose absorvida

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Isvania Maria Serafim da Silva

    2003-02-15

    Dose assessment in an important step to evaluate biological effects as a result of individual exposure to ionizing radiation. The use of cytogenetic dosimetry based on the quantification of micronuclei in lymphocytes is very important to complement physical dosimetry, since the measurement of absorbed dose cannot be always performed. In this research, the quantification of micronuclei was carried out in order to evaluate absorbed dose as a result of radiotherapy with {sup 60}Co, using peripheral blood samples from 5 patients with cervical uterine cancer. For this purpose, an aliquot of whole blood from the individual patients was added in culture medium RPMI 1640 supplemented with fetal calf serum and phytohaemagglutinin. The culture was incubated for 44 hours. Henceforth, cytochalasin B was added to block the dividing lymphocytes in cytokinesis. The culture was returned to the incubator for further of 28 hours. Thus, cells were harvested, processed and analyzed. Values obtained considering micronuclei frequency after pelvis irradiation with absorption of 0,08 Gy and 1,8 Gy were, respectively, 0,0021 and 0,052. These results are in agreement with some recent researches that provided some standard values related to micronuclei frequency induced by gamma radiation exposure in different exposed areas for the human body. The results presented in this report emphasizes biological dosimetry as an important tool for dose assessment of either total or partial-body exposure to ionizing radiation, mainly in retrospective dose investigation. (author)

  13. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Yunisrina Qismullah Yusuf

    2016-03-01

    Full Text Available Guidelines for Article Submission SiELE journal accepts articles on research and development in the field of teaching and learning of English, linguistics, educational development, policy and cultural studies in education. To be considered for publication, the article should be presented in the following system: First page: include a title page with the full title of the paper (must not exceed 16 words, the author(s’ name(s, affiliation(s, phone number(s and e-mail address of the corresponding author. A brief bio-data of the author(s (maximum of 100 words is provided in this page. Second p age and subsequent page: Submissions should be between 4000-6000 (including abstract, table(s, figure(s and references in A4 size paper with margins as the following: top 3 cm, bottom 3 cm, right 2.5 cm and left 4 cm. The font is Times New Roman, size 12 and single spaced. The article should generally consist of the following sections: introduction, review of literature, method, findings, discussion and conclusion. Headings and subheadings should be presented as follows (provide a space between the headings and sub-headings. 1 INTRODUCTION 1.1 Subheading of the Content 1.1.1 Subheading of the Content For Tables, the title size is 12 and the content size is 10. Please number the tables subsequently throughout your article and the title is written above the table. For Figures, the title size is 12 and the content size (if any is 10. Please number the figures subsequently throughout your article and the title is written below the figure. The reference list should be arranged alphabetically following the guidelines of the Publication Manual of the American Psychological Association (5th ed.. See the following examples:   Book: Ellis, R. (2003. Task-based language learning and teaching. Oxford: Oxford University Press. Internet source: Andrewes, S. (2003. Group work v. whole-class activities. Retrieved October 1, 2012 from http://www.teachingenglish.org

  14. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Yunisrina Qismullah Yusuf

    2014-09-01

    Full Text Available Guidelines for Article Submission SiELE journal accepts articles on research and development in the field of teaching and learning of English, linguistics, educational development, policy and cultural studies in education.To be considered for publication, the article should be presented in the following system:First page: include a title page with the full title of the paper (must not exceed 16 words, the author(s’ name(s, affiliation(s, phone number(s and e-mail address of the corresponding author. A brief bio-data of the author(s (maximum of 100 words is provided in this page.Second page and subsequent page: Submissions should be between 4000-6000 (including abstract, table(s, figure(s and references in A4 size paper with margins as the following: top 3 cm, bottom 3 cm, right 2.5 cm and left 4 cm. The font is Times New Roman, size 12 and single spaced. The article should generally consist of the following sections: introduction, review of literature, method, findings, discussion and conclusion.Headings and subheadings should be presented as follows (provide a space between the headings and sub-headings. 1         INTRODUCTION1.1      Subheading of the content 1.1.1   Subheading of the content  For Tables, the title size is 12 and the content size is 10. Please number the tables subsequently throughout your article and the title is written above the table.For Figures, the title size is 12 and the content size (if any is 10. Please number the figures subsequently throughout your article and the title is written below the figure.The reference list should be arranged alphabetically following the guidelines of the Publication Manual of the American Psychological Association (5th ed.. See the following examples: Book: Ellis, R. (2003. Task-based language learning and teaching. Oxford: Oxford University Press.Internet source: Andrewes, S. (2003. Group work v. whole-class activities. Retrieved October 1, 2012 from http://www

  15. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Yunisrina Qismullah Yusuf

    2015-10-01

    Full Text Available Guidelines for Article Submission SiELE journal accepts articles on research and development in the field of teaching and learning of English, linguistics, educational development, policy and cultural studies in education.To be considered for publication, the article should be presented in the following system:First page: include a title page with the full title of the paper (must not exceed 16 words, the author(s’ name(s, affiliation(s, phone number(s and e-mail address of the corresponding author. A brief bio-data of the author(s (maximum of 100 words is provided in this page.Second page and subsequent page: Submissions should be between 4000-6000 (including abstract, table(s, figure(s and references in A4 size paper with margins as the following: top 3 cm, bottom 3 cm, right 2.5 cm and left 4 cm. The font is Times New Roman, size 12 and single spaced. The article should generally consist of the following sections: introduction, review of literature, method, findings, discussion and conclusion.Headings and subheadings should be presented as follows (provide a space between the headings and sub-headings. 1         INTRODUCTION1.1      Subheading of the Content 1.1.1   Subheading of the Content  For Tables, the title size is 12 and the content size is 10. Please number the tables subsequently throughout your article and the title is written above the table.For Figures, the title size is 12 and the content size (if any is 10. Please number the figures subsequently throughout your article and the title is written below the figure.The reference list should be arranged alphabetically following the guidelines of the Publication Manual of the American Psychological Association (5th ed.. See the following examples: Book: Ellis, R. (2003. Task-based language learning and teaching. Oxford: Oxford University Press.Internet source: Andrewes, S. (2003. Group work v. whole-class activities. Retrieved October 1, 2012 from http://www

  16. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Yunisrina Qismullah Yusuf

    2015-03-01

    Full Text Available Guidelines for Article Submission SiELE journal accepts articles on research and development in the field of teaching and learning of English, linguistics, educational development, policy and cultural studies in education. To be considered for publication, the article should be presented in the following system: First page: include a title page with the full title of the paper (must not exceed 16 words, the author(s’ name(s, affiliation(s, phone number(s and e-mail address of the corresponding author. A brief bio-data of the author(s (maximum of 100 words is provided in this page. Second page and subsequent page: Submissions should be between 4000-6000 (including abstract, table(s, figure(s and references in A4 size paper with margins as the following: top 3 cm, bottom 3 cm, right 2.5 cm and left 4 cm. The font is Times New Roman, size 12 and single spaced. The article should generally consist of the following sections: introduction, review of literature, method, findings, discussion and conclusion. Headings and subheadings should be presented as follows (provide a space between the headings and sub-headings. 1 INTRODUCTION 1.1 Subheading of the content 1.1.1 Subheading of the content For Tables, the title size is 12 and the content size is 10. Please number the tables subsequently throughout your article and the title is written above the table. For Figures, the title size is 12 and the content size (if any is 10. Please number the figures subsequently throughout your article and the title is written below the figure. The reference list should be arranged alphabetically following the guidelines of the Publication Manual of the American Psychological Association (5th ed.. See the following examples: Back Matter| 79 80 | STUDIES IN ENGLISH LANGUAGE AND EDUCATION, Volume 1, Number 1, March 2014 Book: Ellis, R. (2003. Task-based language learning and teaching. Oxford: Oxford University Press. Internet source: Andrewes, S. (2003. Group work v

  17. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Yunisrina Qismullah Yusuf

    2014-03-01

    Full Text Available Guidelines for Article Submission SiELE journal accepts articles on research and development in the field of teaching and learning of English, linguistics, educational development, policy and cultural studies in education.To be considered for publication, the article should be presented in the following system:First page: include a title page with the full title of the paper (must not exceed 16 words, the author(s’ name(s, affiliation(s, phone number(s and e-mail address of the corresponding author. A brief bio-data of the author(s (maximum of 100 words is provided in this page.Second page and subsequent page: Submissions should be between 4000-6000 (including abstract, table(s, figure(s and references in A4 size paper with margins as the following: top 3 cm, bottom 3 cm, right 2.5 cm and left 4 cm. The font is Times New Roman, size 12 and single spaced. The article should generally consist of the following sections: introduction, review of literature, method, findings, discussion and conclusion.Headings and subheadings should be presented as follows (provide a space between the headings and sub-headings. 1         INTRODUCTION1.1      Subheading of the content 1.1.1   Subheading of the content  For Tables, the title size is 12 and the content size is 10. Please number the tables subsequently throughout your article and the title is written above the table.For Figures, the title size is 12 and the content size (if any is 10. Please number the figures subsequently throughout your article and the title is written below the figure.The reference list should be arranged alphabetically following the guidelines of the Publication Manual of the American Psychological Association (5th ed.. See the following examples: Book: Ellis, R. (2003. Task-based language learning and teaching. Oxford: Oxford University Press.Internet source: Andrewes, S. (2003. Group work v. whole-class activities. Retrieved October 1, 2012 from http://www

  18. Field assessment of semi-aerobic condition and the methane correction factor for the semi-aerobic landfills provided by IPCC guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Sangjae [Department of Civil and Environmental Engineering, College of Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (Korea, Republic of); Nam, Anwoo [Korea Environment Corporation, 42 Hwangyeong-ro, Seo-gu, Incheon 404-170 (Korea, Republic of); Yi, Seung-Muk [Department of Environmental Health, School of Public Health, Seoul National University, Seoul 151-742 (Korea, Republic of); Kim, Jae Young, E-mail: jaeykim@snu.ac.kr [Department of Civil and Environmental Engineering, College of Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (Korea, Republic of)

    2015-02-15

    Highlights: • CH{sub 4}/CO{sub 2} and CH{sub 4} + CO{sub 2}% are proposed as indices to evaluate semi-aerobic landfills. • A landfill which CH{sub 4}/CO{sub 2} > 1.0 is difficult to be categorized as semi-aerobic landfill. • Field conditions should be carefully investigated to determine landfill types. • The MCF default value for semi-aerobic landfills underestimates the methane emissions. - Abstract: According to IPCC guidelines, a semi-aerobic landfill site produces one-half of the amount of CH{sub 4} produced by an equally-sized anaerobic landfill site. Therefore categorizing the landfill type is important on greenhouse gas inventories. In order to assess semi-aerobic condition in the sites and the MCF value for semi-aerobic landfill, landfill gas has been measured from vent pipes in five semi-aerobically designed landfills in South Korea. All of the five sites satisfied requirements of semi-aerobic landfills in 2006 IPCC guidelines. However, the ends of leachate collection pipes which are main entrance of air in the semi-aerobic landfill were closed in all five sites. The CH{sub 4}/CO{sub 2} ratio in landfill gas, indicator of aerobic and anaerobic decomposition, ranged from 1.08 to 1.46 which is higher than the values (0.3–1.0) reported for semi-aerobic landfill sites and is rather close to those (1.0–2.0) for anaerobic landfill sites. The low CH{sub 4} + CO{sub 2}% in landfill gas implied air intrusion into the landfill. However, there was no evidence that air intrusion has caused by semi-aerobic design and operation. Therefore, the landfills investigated in this study are difficult to be classified as semi-aerobic landfills. Also MCF of 0.5 may significantly underestimate methane emissions compared to other researches. According to the carbon mass balance analyses, the higher MCF needs to be proposed for semi-aerobic landfills. Consequently, methane emission estimate should be based on field evaluation for the semi-aerobically designed landfills.

  19. A scientific and animal welfare assessment of the OECD Health Effects Test Guidelines for the safety testing of chemicals under the European Union REACH system.

    Science.gov (United States)

    Combes, Robert; Gaunt, Ian; Balls, Michael

    2006-03-01

    We have assessed each of the OECD Health Effects Test Guidelines (TGs) that were included in an annex to the Internet consultation issued by the European Commission relating to the Registration, Evaluation and Authorisation of Chemicals (REACH) legislation for the testing of new and existing chemical substances. Each guideline has been analysed with respect to its design and its scientific and animal welfare implications, the extent to which it makes use of modern techniques, and its suitability to be used in the REACH system for the testing of large numbers of chemicals. The scientific basis of the test and its justification are considered, as well as the numbers of animals required, and the potential adverse effects on them. The prospects and possibilities for applying the Three Rs (reduction, refinement and replacement) to each of the TGs are also discussed. We have proposed an overall testing strategy for how these TGs and other methods could best be deployed for chemicals testing, should it be necessary to fill data gaps. Certain TGs have been omitted from the strategy, when we have considered them to be unnecessary for chemicals testing. A series of recommendations has been made for improving the TGs with regard to both their scientific content and ways in which they could be better designed in relation to optimising the use of the animals concerned, and minimising adverse welfare consequences to them. Our investigations show that there is an urgent need to update the TGs to reflect modern techniques and methods, and to use current approaches for applying refinement strategies to improve the scientific and animal welfare aspects of the procedures used. Improvements can and should be made in all aspects of toxicity testing, from sample preparation, and animal housing, care and feeding, to dose formulation, test material administration, and the histopathological and clinical analysis of tissue samples. Opportunities for streamlining individual assays are very

  20. Assessment of a 1H high-resolution magic angle spinning NMR spectroscopy procedure for free sugars quantification in intact plant tissue.

    Science.gov (United States)

    Delgado-Goñi, Teresa; Campo, Sonia; Martín-Sitjar, Juana; Cabañas, Miquel E; San Segundo, Blanca; Arús, Carles

    2013-08-01

    In most plants, sucrose is the primary product of photosynthesis, the transport form of assimilated carbon, and also one of the main factors determining sweetness in fresh fruits. Traditional methods for sugar quantification (mainly sucrose, glucose and fructose) require obtaining crude plant extracts, which sometimes involve substantial sample manipulation, making the process time-consuming and increasing the risk of sample degradation. Here, we describe and validate a fast method to determine sugar content in intact plant tissue by using high-resolution magic angle spinning nuclear magnetic resonance spectroscopy (HR-MAS NMR). The HR-MAS NMR method was used for quantifying sucrose, glucose and fructose in mesocarp tissues from melon fruits (Cucumis melo var. reticulatus and Cucumis melo var. cantalupensis). The resulting sugar content varied among individual melons, ranging from 1.4 to 7.3 g of sucrose, 0.4-2.5 g of glucose; and 0.73-2.83 g of fructose (values per 100 g fw). These values were in agreement with those described in the literature for melon fruit tissue, and no significant differences were found when comparing them with those obtained using the traditional, enzymatic procedure, on melon tissue extracts. The HR-MAS NMR method offers a fast (usually <30 min) and sensitive method for sugar quantification in intact plant tissues, it requires a small amount of tissue (typically 50 mg fw) and avoids the interferences and risks associated with obtaining plant extracts. Furthermore, this method might also allow the quantification of additional metabolites detectable in the plant tissue NMR spectrum. PMID:23824526

  1. Piston pin noise. Quantification and assessment of the influence of pin and pin bore geometry; Kolbenbolzengeraeusch. Verfahren zur Quantifizierung und Einfluss der Nabengeometrie

    Energy Technology Data Exchange (ETDEWEB)

    Werkmann, M.; Tunsch, M.; Kuenzel, R. [Mahle International GmbH, Stuttgart (Germany)

    2005-07-01

    The irregular appearance of noise which is caused by the interaction of piston pin and piston pin boss is subjectively perceived as strongly annoying. For a gasoline engine with floating pin desing the effect of shock excitation related to pin and pin boss on airborne and structure-borne noise will be shown in dependency on water temperature and engine speed. The measurement procedure for detecting piston pin noise as well as the evaluation method for quantification in the time range will be described. Using examples the influence of different parameters on piston pin noise like pin fitting clearance and various pin bore geometries will be presented.

  2. AUTHOR GUIDELINES

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2014-12-01

    Full Text Available AUTHOR GUIDELINESIndian Journal of Community Health (IJCH accepts only online submission of manuscript(s by using Open Journal software (OJS at http://www.iapsmupuk.org/journal/index.php/IJCH/loginOnline SubmissionsAlready have a Username/Password for Indian Journal of Community Health (IJCH? GO TO LOGINNeed a Username/Password?GO TO REGISTRATIONNote: Registration and login are required to submit items online and to track the status of current submissions.Author GuidelinesIJCH strictly adheres on the recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals as per the standard universal guidelines given by International Committee of Medical Journal Editors (ICMJE - Recommendations for Uniform Requirements for Manuscripts. Authors are requested to visit http://www.icmje.org/index.html before making online submission of their manuscript(s.SectionsEditorial:On issues of current public health needAbout 1000 – 1200 wordsReferences: 5 – 10 (PubMed - Citation preferredInvited Commentary:Brief, provocative, opinionated communicationsOn issues of current public health needMain Text: 750-1000 words excluding referencesReferences: 5 – 10 (PubMed - Citation preferredOriginal Article:Articles from Original ResearchStructured abstract: 250 wordsMain Text: 2500 - 3000 words, IMRD formatKey Words: 5 - 8References: 20 – 25 (PubMed - Citation preferredTables / Figures: 3 – 4*Certificate of clearance from respective Institutional Ethical Committee (IECReview Article:On subject of public health relevanceAbstract: 250 wordsMain Text: 2500 - 3000 wordsKey Words: 3 - 4References: 20 – 25 (PubMed - Citation preferredTables / Figures: 3 – 4Short Communication / Article:Short report of a research project / outbreakMain Text : 1000 – 1200 wordsReferences: 10 – 15 (PubMed - Citation preferredTable / Figure: 01*Certificate of clearance from respective Institutional Ethical Committee (IECReport from the field

  3. Implementing New Reform Guidelines in Teaching Introductory College Statistics Courses

    Science.gov (United States)

    Everson, Michelle; Zieffler, Andrew; Garfield, Joan

    2008-01-01

    This article introduces the recently adopted Guidelines for the Assessment and Instruction in Statistics Education (GAISE) and provides two examples of introductory statistics courses that have been redesigned to better align with these guidelines.

  4. Guidelines for integrated risk assessment and management in large industrial areas. Inter-Agency programme on the assessment and management of health and environmental risks from energy and other complex industrial systems

    International Nuclear Information System (INIS)

    The IAEA, the United Nations Environment Programme (UNEP) within the framework of the Awareness and Preparedness for Emergencies at Local Level (APELL), the United Nations Industrial Development Organization (UNIDO) and the World Health Organization (WHO) decided in 1986 to join forces in order to promote the use of integrated area wide approaches to risk management. An Inter-Agency Programme, which brings together expertise in health the environment, industry and energy, all vital for effective risk management, was established. The Inter-Agency Programme on the assessment and Management of Health and Environmental Risks from Energy and Other Complex Industrial Systems aims at promoting and facilitating the implementation of integrated risk assessment and management for large industrial areas. This initiative includes the compilation of procedures and methods for environmental and public health risk assessment, the transfer of knowledge and experience amongst countries in the application of these procedures and the implementation of an integrated approach to risk management. The purpose of the Inter-Agency Programme is to develop a broad approach to the identification, prioritization and minimization of industrial hazards in a given geographical area. The UN organizations sponsoring this programme have been involved for several years in activities aimed at assessment and management of environmental and health risks, prevention of major accidents and emergency preparedness. These Guidelines have been developed on the basis of experience from these activities to assist in the planning and conduct of regional risk management projects. They provide a reference framework for the undertaking of integrated health and environmental risk assessment for large industrial areas and for the formulation of appropriate risk management strategies

  5. Whole farm quantification of GHG emissions within smallholder farms in developing countries

    International Nuclear Information System (INIS)

    The IPCC has compiled the best available scientific methods into published guidelines for estimating greenhouse gas emissions and emission removals from the land-use sector. In order to evaluate existing GHG quantification tools to comprehensively quantify GHG emissions and removals in smallholder conditions, farm scale quantification was tested with farm data from Western Kenya. After conducting a cluster analysis to identify different farm typologies GHG quantification was exercised using the VCS SALM methodology complemented with IPCC livestock emission factors and the cool farm tool. The emission profiles of four farm clusters representing the baseline conditions in the year 2009 are compared with 2011 where farmers adopted sustainable land management practices (SALM). The results demonstrate the variation in both the magnitude of the estimated GHG emissions per ha between different smallholder farm typologies and the emissions estimated by applying two different accounting tools. The farm scale quantification further shows that the adoption of SALM has a significant impact on emission reduction and removals and the mitigation benefits range between 4 and 6.5 tCO2 ha−1 yr−1 with significantly different mitigation benefits depending on typologies of the crop–livestock systems, their different agricultural practices, as well as adoption rates of improved practices. However, the inherent uncertainty related to the emission factors applied by accounting tools has substantial implications for reported agricultural emissions. With regard to uncertainty related to activity data, the assessment confirms the high variability within different farm types as well as between different parameters surveyed to comprehensively quantify GHG emissions within smallholder farms. (paper)

  6. Whole farm quantification of GHG emissions within smallholder farms in developing countries

    Science.gov (United States)

    Seebauer, Matthias

    2014-03-01

    The IPCC has compiled the best available scientific methods into published guidelines for estimating greenhouse gas emissions and emission removals from the land-use sector. In order to evaluate existing GHG quantification tools to comprehensively quantify GHG emissions and removals in smallholder conditions, farm scale quantification was tested with farm data from Western Kenya. After conducting a cluster analysis to identify different farm typologies GHG quantification was exercised using the VCS SALM methodology complemented with IPCC livestock emission factors and the cool farm tool. The emission profiles of four farm clusters representing the baseline conditions in the year 2009 are compared with 2011 where farmers adopted sustainable land management practices (SALM). The results demonstrate the variation in both the magnitude of the estimated GHG emissions per ha between different smallholder farm typologies and the emissions estimated by applying two different accounting tools. The farm scale quantification further shows that the adoption of SALM has a significant impact on emission reduction and removals and the mitigation benefits range between 4 and 6.5 tCO2 ha-1 yr-1 with significantly different mitigation benefits depending on typologies of the crop-livestock systems, their different agricultural practices, as well as adoption rates of improved practices. However, the inherent uncertainty related to the emission factors applied by accounting tools has substantial implications for reported agricultural emissions. With regard to uncertainty related to activity data, the assessment confirms the high variability within different farm types as well as between different parameters surveyed to comprehensively quantify GHG emissions within smallholder farms.

  7. Development of a rapid column-switching LC-MS/MS method for the quantification of THCCOOH and THCCOOH-glucuronide in whole blood for assessing cannabis consumption frequency.

    Science.gov (United States)

    Hädener, Marianne; Weinmann, Wolfgang; Schürch, Stefan; König, Stefan

    2016-03-01

    The concentration of 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THCCOOH) in whole blood is used as a parameter for assessing the consumption behavior of cannabis consumers. The blood level of THCCOOH-glucuronide might provide additional information about the frequency of cannabis use. To verify this assumption, a column-switching liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the rapid and direct quantification of free and glucuronidated THCCOOH in human whole blood was newly developed. The method comprised protein precipitation, followed by injection of the processed sample onto a trapping column and subsequent gradient elution to an analytical column for separation and detection. The total LC run time was 4.5 min. Detection of the analytes was accomplished by electrospray ionization in positive ion mode and selected reaction monitoring using a triple-stage quadrupole mass spectrometer. The method was fully validated by evaluating the following parameters: linearity, lower limit of quantification, accuracy and imprecision, selectivity, extraction efficiency, matrix effect, carry-over, dilution integrity, analyte stability, and re-injection reproducibility. All acceptance criteria were analyzed and the predefined criteria met. Linearity ranged from 5.0 to 500 μg/L for both analytes. The method was successfully applied to whole blood samples from a large collective of cannabis consumers, demonstrating its applicability in the forensic field. PMID:26781107

  8. Development of environmental guidelines for electronic appliances

    DEFF Research Database (Denmark)

    Legarth, Jens Brøbech; Alting, Leo; Erichsen, Hanne K. Linnet; Gregersen, Johan Chr; Jørgensen, Jørgen

    This paper presents a general method for the development of environmental guidelines for complex products. The method is based on the life cycle concept. The application of life cycle assessment methods reveals the peak environmental impacts, and their source resulting in environmental guidelines...

  9. Clinical Practice Guidelines for Acute Pericarditis Treatment

    OpenAIRE

    Félix Rolando Jorrín Román; Lázaro De la Cruz Aviles; Roberto Vega Hernández; Francisco Riverón Mena

    2009-01-01

    Clinical Practice Guidelines for Acute Pericarditis Treatment. It has been defined as a syndrome caused by the inflammation of the pericardium for diverse aetiologies. The etiological agents, clinical presentation, diagnostic methods and steps that must be taken are described in this document. It includes assessment guidelines focused on the most important aspects to be accomplished.

  10. Clinical Practice Guidelines for paroxysmal supraventricular tachycardia.

    OpenAIRE

    Brandy Viera Valdés; Francisco de Jesús Valladares Carvajal; Félix Rolando Jorrín Román; Pablo Rodríguez Díaz

    2009-01-01

    Clinical Practice Guidelines for paroxysmal supraventricular tachycardia. These are arrhythmias in which structures placed above the bifurcation of the bundle of His are involved; characterized by tachycardia with abrupt starting and ending. We comment its classification, common characteristics, general treatment and specific conduct for its different variables. It includes assessment guidelines focused on the most important aspects to be accomplished.

  11. Clinical Practice Guidelines for Encephalic Death Treatment

    OpenAIRE

    José Roque Nodal Arruebarrena; José Noel Marrero Rodríguez; Argelio Santana Cano; Julio Jova Dueñas

    2009-01-01

    Clinical Practice Guidelines for Encephalic Death Treatment. It has been defined as the irreversible ceasing of all encephalic functions (cerebral hemispheres, of the encephalic stalk and cerebellum). This document includes the diagnostic criteria and its workflow and comments on the diagnostic tests and its legal aspects. It includes assessment guidelines focused on the most important aspects to be accomplished.

  12. Clinical Practice Guidelines for Acute Pancreatitis Treatment.

    OpenAIRE

    Francisco García Valdés; Jorge Luis Ulloa Capestany; Reinaldo Jiménez Prendes; Rudis Miguel Monzón Rodríguez; Carlos Jaime Geroy Gómez

    2009-01-01

    Clinical Practice Guidelines for Acute Pancreatitis Treatment. It is the acute inflammatory reaction of the pancreas, affecting a gland that was previously healthy and causes its self-digestion with variable complications of local and distal systems of organs. Its etiological agents, clinical presentation, diagnostic methods and therapy are described. It includes assessment guidelines focused on the most important aspects to be accomplished.

  13. Clinical Practice Guidelines for Ventilation Associated Pneumonia.

    OpenAIRE

    Marcos Diosdado Iraola Ferrer; Belkys Rodríguez Llerena.; Héctor Cruz de los Santos.; Eddy Pereira Valdés

    2009-01-01

    Clinical Practice Guidelines for Ventilation Associated Pneumonia. Conceptualized as the bacterial pneumonia that develops in patients receiving mechanical ventilation for more than 48 hours, which is not present at the beginning of the ventilation. We review the concept, prevention and treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  14. Clinical Practice Guidelines for Auricular Fibrillation.

    OpenAIRE

    Lázaro De la Cruz Avilés; Félix Rolando Jorrín Román; Francisco de Jesús Valladares Carvajal; Pablo Rodríguez Díaz

    2009-01-01

    Clinical Practice Guidelines for Auricular Fibrillation. This is the most common cardiac arrhythmia and can bring about deleterious consequences on the cardiac function and risk of systemic embolism. It includes important aspects as aetiology and trigger aspects, diagnosis, classification and treatment with emphasis on therapeutic emergencies. It includes assessment guidelines focused on the most important aspects to be accomplished.

  15. Clinical Practice Guidelines for Unstable Angina Treatment.

    OpenAIRE

    Juan José Navarro López; Claudio Manuel González Rodríguez

    2009-01-01

    Clinical Practice Guidelines for Unstable Angina Treatment. It has been defined as the oppressive pain or uneasiness mainly thoracic, which is caused by a transitory myocardial ischemia. This document includes important aspects as classification, diagnosis, treatment (aimed at its principal strategies) and risk stratification. It includes assessment guidelines focused on the most important aspects to be accomplished.

  16. Clinical Practice Guidelines for Exogenous Poisoning.

    OpenAIRE

    Alexis Díaz Mesa; Eddy Pereira Valdés; Alba Enseñat Álvarez; Carlos Alberto Rodríguez Armada

    2009-01-01

    Clinical Practice Guidelines for Exogenous Poisoning. Medical emergencies determined by the exposure to different substances (drugs, medicines, physical or chemical corrosive agents, etc). It includes the classification of toxic substances, clinical diagnosis (main syndromes), and description of therapeutic variations (vital support, antidotes, absorption measurements and increase of elimination and depuration of the toxic substance). It includes assessment guidelines focused on the most impo...

  17. Clinical Practice Guidelines for Peritonitis Treatment.

    OpenAIRE

    Frank Carlos Alvarez Li; Carlos Jaime Geroy Gómez; Diosdania Alfonso Falcón; Alexis Díaz Mesa

    2009-01-01

    Clinical Practice Guidelines for Peritonitis Treatment. It is a general or local inflammatory process of the peritoneal membrane after a chemical irritation, bacterial invasion (intra-abdominal infection), local necrosis or direct contusion. It includes concept, classification, diagnosis, and medical and surgical treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  18. Clinical Practice Guidelines for intestinal occlusion.

    OpenAIRE

    Rudis Miguel Monzón Rodríguez; Carlos Jaime Geroy Gómez; Francisco García Valdéz; Jorge Luis Ulloa Capestany; Maribel Misas Menéndez

    2009-01-01

    Clinical Practice Guidelines for intestinal occlusion. This document includes the main aspects related with classification, physiopathology, clinical diagnosis, complementary examinations and therapy aimed at the post-operatory treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  19. Rapid quantification of viable Campylobacter on chicken carcasses by real-time PCR and propidium monoazide as a tool for quantitative risk assessment

    DEFF Research Database (Denmark)

    Josefsen, Mathilde Hartmann; Löfström, Charlotta; Hansen, Tina Beck; Christensen, Laurids Siig; Olsen, John Elmerdahl; Hoorfar, Jeffrey

    2010-01-01

    A number of intervention strategies against Campylobacter contaminated poultry focus on post-slaughter reduction of the number of cells, emphasizing the need for rapid and reliable quantitative detection of only viable Campylobacter. We present a new and rapid quantitative approach for enumeration...... of foodborne Campylobacter, combining real-time PCR (Q-PCR) with a simple propidium monoazide (PMA) sample treatment. In less than 3 hours, this method generates a signal from only viable and viable but non-culturable (VBNC) Campylobacter with an intact membrane. The method performance was evaluated...... correlated with Ct-values (R2 = 0.993), with a quantification range from 1×1021×107 CFU/ml. The correlation between the Campylobacter counts obtained by PMA-PCR and culture on naturally contaminated chickens was high (R2 = 0.844). The amplification efficiency of the Q-PCR method was not affected by chicken...

  20. Introduction to uncertainty quantification

    CERN Document Server

    Sullivan, T J

    2015-01-01

    Uncertainty quantification is a topic of increasing practical importance at the intersection of applied mathematics, statistics, computation, and numerous application areas in science and engineering. This text provides a framework in which the main objectives of the field of uncertainty quantification are defined, and an overview of the range of mathematical methods by which they can be achieved. Complete with exercises throughout, the book will equip readers with both theoretical understanding and practical experience of the key mathematical and algorithmic tools underlying the treatment of uncertainty in modern applied mathematics. Students and readers alike are encouraged to apply the mathematical methods discussed in this book to their own favourite problems to understand their strengths and weaknesses, also making the text suitable as a self-study. This text is designed as an introduction to uncertainty quantification for senior undergraduate and graduate students with a mathematical or statistical back...

  1. Clinical Practice Guidelines for Potential Donors Management

    Directory of Open Access Journals (Sweden)

    José Roque Nodal Arruebarrena

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Potential Donors Management. It has been defined as the patient in Glasgow coma with scale higher or equal to 8 who doesn´t present contradictions for transplant (possible donor and who has been diagnosed of encephalic death. This document reviews and updates concepts, lists indications and contraindications for different organs donation, clinical assessment of the donor and its treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  2. Clinical Practice Guidelines for Potential Donors Management

    OpenAIRE

    José Roque Nodal Arruebarrena; José Noel Marrero Rodríguez; Yenisey Quintero Menéndez; Aida M. Reyes Pérez; Julio Jova Dueñas

    2009-01-01

    Clinical Practice Guidelines for Potential Donors Management. It has been defined as the patient in Glasgow coma with scale higher or equal to 8 who doesn´t present contradictions for transplant (possible donor) and who has been diagnosed of encephalic death. This document reviews and updates concepts, lists indications and contraindications for different organs donation, clinical assessment of the donor and its treatment. It includes assessment guidelines focused on the most important aspect...

  3. FineSplice, enhanced splice junction detection and quantification: a novel pipeline based on the assessment of diverse RNA-Seq alignment solutions.

    Science.gov (United States)

    Gatto, Alberto; Torroja-Fungairiño, Carlos; Mazzarotto, Francesco; Cook, Stuart A; Barton, Paul J R; Sánchez-Cabo, Fátima; Lara-Pezzi, Enrique

    2014-04-01

    Alternative splicing is the main mechanism governing protein diversity. The recent developments in RNA-Seq technology have enabled the study of the global impact and regulation of this biological process. However, the lack of standardized protocols constitutes a major bottleneck in the analysis of alternative splicing. This is particularly important for the identification of exon-exon junctions, which is a critical step in any analysis workflow. Here we performed a systematic benchmarking of alignment tools to dissect the impact of design and method on the mapping, detection and quantification of splice junctions from multi-exon reads. Accordingly, we devised a novel pipeline based on TopHat2 combined with a splice junction detection algorithm, which we have named FineSplice. FineSplice allows effective elimination of spurious junction hits arising from artefactual alignments, achieving up to 99% precision in both real and simulated data sets and yielding superior F1 scores under most tested conditions. The proposed strategy conjugates an efficient mapping solution with a semi-supervised anomaly detection scheme to filter out false positives and allows reliable estimation of expressed junctions from the alignment output. Ultimately this provides more accurate information to identify meaningful splicing patterns. FineSplice is freely available at https://sourceforge.net/p/finesplice/. PMID:24574529

  4. Disease quantification in dermatology

    DEFF Research Database (Denmark)

    Greve, Tanja Maria; Kamp, Søren; Jemec, Gregor B E

    2013-01-01

    Accurate documentation of disease severity is a prerequisite for clinical research and the practice of evidence-based medicine. The quantification of skin diseases such as psoriasis currently relies heavily on clinical scores. Although these clinical scoring methods are well established and very ...

  5. Rethinking guideline toxicity testing.

    Science.gov (United States)

    Saghir, Shakil Ahmed

    2015-07-01

    The guidelines for risk assessment of plant protection products (PPPs) and other non-pharmaceuticals were developed over three decades ago and have generally not been updated to incorporate advancements in toxicology and exposure sciences. These guidelines recommend using maximum-tolerated-dose (MTD) even when human relevance of such high doses is mostly limited due to orders of magnitude margin-of-exposure. Conducting animal studies at such high doses often requires further mode-of-action (MoA) studies elucidating human relevance. In order to improve data, ILSI/HESI-ACSA technical committee proposed a tiered approach with emphasis on determining systemic dose of parent and/or metabolite(s) in test animals as biological effects are reflective of systemic rather than administered dose. Any deviation from linearity in systemic dose (saturation of absorption or elimination) in animal studies may have profound toxic effect(s) not expected to occur in likely human exposure scenarios and should be avoided. Toxicity studies should ideally be conducted at kinetically linear doses or slightly above the point of departure from linearity or kinetically-derived maximum dose (KMD) as the systemic dose nonlinearity is a more sensitive parameter occurring much earlier than the MTD endpoints. Therefore, determining systemic dose, especially KMD, in study animals is an improvement to hazard assessment of PPPs and other non-pharmaceuticals allowing toxicologists to better understand findings in animals at systemically linear as well as nonlinear doses to likely human exposures which can easily be accomplished using core study animals as outlined below. Determining systemic dose in studies will also increase the understanding of initial potential MoA of a PPPs and other non-pharmaceuticals and reduce the use of animals by avoiding unnecessary additional MoA studies. PMID:25980640

  6. Clinical Practice Guidelines for Early Weaning from Mechanical Ventilation.

    OpenAIRE

    Eddy Pereira Valdés

    2009-01-01

    Clinical Practice Guidelines for Early Weaning from Mechanical Ventilation. Weaning is the process, gradual or rapid, that leads to the turn off of mechanical ventilation and allows restoring spontaneous ventilation. The guidelines describe the procedure for rapid weaning from mechanical ventilation and emphasizes on spontaneous ventilation test. It includes assessment guidelines focused on the most important aspects to be accomplished.

  7. How nurses seek and evaluate clinical guidelines on the Internet

    NARCIS (Netherlands)

    Verhoeven, Fenne; Steehouder, Michael F.; Hendrix, Ron M.G.; Gemert-Pijnen, van Julia E.W.C.

    2010-01-01

    Aim: This paper is a report of a study conducted to assess nurses’ information-seeking strategies and problems encountered when seeking clinical guidelines on the Internet, and to investigate the criteria they apply when evaluating the guidelines and the websites communicating the guidelines. - Back

  8. 网络安全风险评估量化模型的研究%The Quantification Model for Network Sceurity Risk Assessment

    Institute of Scientific and Technical Information of China (English)

    段小强; 陈卓; 阮鸥

    2014-01-01

    基于量化的风险评估方法以及现有的风险评估量化模型基础上,提出一种更加完善和详细的风险评估量化模型。%There are a number of methods of network security risk assessment,and the fuzzy comprehen-sive evaluation algorithm is one of typical quantitative risk value methods.The paper proposed a more complete and detailed quantitative model of risk assessment,based on quantitative risk assessment meth-ods and risk assessment of existing quantitative model.

  9. Lessons in uncertainty quantification for turbulent dynamical systems

    OpenAIRE

    Majda, A. J.; M. Branicki

    2012-01-01

    The modus operandi of modern applied mathematics in developing very recent mathematical strategies for uncertainty quantification in partially observed high-dimensional turbulent dynamical systems is emphasized here. The approach involves the synergy of rigorous mathematical guidelines with a suite of physically relevant and progressively more complex test models which are mathematically tractable while possessing such important features as the two-way coupling between the resolved dynamics a...

  10. Robust optimization of well location to enhance hysteretical trapping of CO2: Assessment of various uncertainty quantification methods and utilization of mixed response surface surrogates

    Science.gov (United States)

    Babaei, Masoud; Pan, Indranil; Alkhatib, Ali

    2015-12-01

    The paper aims to solve a robust optimization problem (optimization in presence of uncertainty) for finding the optimal locations of a number of CO2 injection wells for geological sequestration of carbon dioxide in a saline aquifer. The parametric uncertainties are the interfacial tension between CO2 and aquifer brine, the Land's trapping coefficient and the boundary aquifer's absolute permeability. The spatial uncertainties are due to the channelized permeability field which exhibits a binary channel-non-channel system. The objective function of the optimization is the amount of residually trapped CO2 due to the hysteresis of the relative permeability curves. A risk-averse value derived from the cumulative density function of the distribution of the amount of trapped gas is chosen as the objective function value. In order to ensure that the uncertainties are effectively taken into account, Monte Carlo simulation and Polynomial Chaos Expansion (PCE)-based methods are used and compared with each other. For different cases of parametric and spatial uncertainties, the most accurate uncertainty quantification (UQ) method is chosen to be integrated within the optimization algorithm. While for parametric uncertainty cases of up to two uncertain variables, PCE-based methods computationally outperform Monte Carlo simulations, it is shown that for the multimodal distributions of the function of trapped gas occurring for the spatial uncertainty case, Monte Carlo simulations are more reliable than PCE-based UQ methods. For the discrete (integer) optimization problem, various mixed response surface surrogate models are tested and the robust optimization resulted in optimal CO2 injection well locations.

  11. Assessment of flow quantification in coronary bypass grafts and coronary arteries with velocity-encoded cine MR imaging; Flussquantifizierung in Koronar- und Bypassgefaessen mit der MR-Phasenkontrasttechnik

    Energy Technology Data Exchange (ETDEWEB)

    Kreitner, K.F.; Kalden, P.; Thelen, M. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Voigtlaender, T.; Wittlinger, T.; Meyer, J. [Mainz Univ. (Germany). 2. Medizinische Klinik und Poliklinik; Dahm, M. [Mainz Univ. (Germany). Klinik fuer Herz-, Thorax-, und Gefaesschirurgie

    2000-02-01

    Materials and methods: 12 patients with 22 coronary bypass grafts underwent intraoperative flow quantification using the transit time ultrasound method. These values were compared to postoperative MR phase shift measurements. Flow measurements were performed preoperatively in 28 coronary arteries of 20 patients. For flow measurement, we used a velocity-encoded k-space segmented gradient echo sequence with a temporal resolution of 110 or 125 ms, respectively. 6-8 pase shift images could be acquired during one cardiac cycle. Results: There was a significant correlation between intraoperative and flow measurements using velocity-encoded MR imaging (r=0.76, p<0.0001, t-test). Flow volumes determined by MR imaging were systematically larger than those determined by the transit time ultrasound method. Mean flow in coronary arteries was reduced in severely stenosed vessels (>70%) compared to normal vessels. Intra- and interobserver variability were 10.5 and 15% (coronary bypass grafts), and 12.3 and 15.8% (coronary arteries), respectively. (orig.) [German] Material und Methode: Die MRT-Flussmessungen von 12 Patienten mit 22 Bypassgefaessen wurden mit intraoperativ mittels Ultraschalldurchflussmethode bestimmten Fluessen verglichen. Praeoperativ wurden zusaetzlich Flussmessungen in 28 Koronararterien von 20 Patienten durchgefuehrt. Zur MRT-Flussmessung wurde eine segmentierte 2D-Flash-Sequenz verwendet, die eine zeitliche Aufloesung von 110 bzw. 125 ms aufwies. Dies ermoeglichte die Akquisition von 6-8 Bildpaaren pro Herzzyklus. Ergebnisse: Es bestand eine signifikante Korrelation zwischen den Ergebnissen der intraoperativen und denen der postoperativen MRT-Flussmessung (r=0,76, p<0,0001, t-Test). Das mit der MRT gemessene Flussvolumen lag ueber dem bei der Ultraschallmessung ermittelten. Die Bestimmung des mittleren Flusses in den Koronararterien zeigte deutliche Unterschiede zwischen Gefaessen mit hoehergradiger Stenose (>70%) und Gefaessen ohne Stenose. Die Intra- und

  12. Guideline of guidelines: thromboprophylaxis for urological surgery.

    Science.gov (United States)

    Violette, Philippe D; Cartwright, Rufus; Briel, Matthias; Tikkinen, Kari A O; Guyatt, Gordon H

    2016-09-01

    Decisions regarding thromboprophylaxis in urologic surgery involve a trade-off between decreased risk of venous thromboembolism (VTE) and increased risk of bleeding. Both patient- and procedure-specific factors are critical in making an informed decision on the use of thromboprophylaxis. Our systematic review of the literature revealed that existing guidelines in urology are limited. Recommendations from national and international guidelines often conflict and are largely based on indirect as opposed to procedure-specific evidence. These issues have likely contributed to large variation in the use of VTE prophylaxis within and between countries. The majority of existing guidelines typically suggest prolonged thromboprophylaxis for high-risk abdominal or pelvic surgery, without clear clarification of what these procedures are, for up to 4 weeks post-discharge. Existing guidance may result in the under-treatment of procedures with low risk of bleeding and the over-treatment of oncological procedures with low risk of VTE. Guidance for patients who are already anticoagulated are not specific to urological procedures but generally involve evaluating patient and surgical risks when deciding on bridging therapy. The European Association of Urology Guidelines Office has commissioned an ad hoc guideline panel that will present a formal thromboprophylaxis guideline for specific urological procedures and patient risk factors. PMID:27037846

  13. Guidelines and workbook for of organization and administration of utilities seeking operating license for a nuclear power plant. Workbook for assessment of organization and management. Volume, 2, Revision 1

    International Nuclear Information System (INIS)

    This report is a partial response to the requirements of Item I.B.1.1 of the ''NRC Action Plan Developed as a Result of the TMI-2 Accident,'' NUREG-0660, and is designed to serve as a basis for replacing the earlier NUREG-0731, ''Guidelines for Utility Management Structure and Technical Resources.'' The Guidelines are intended to provide guidance to the user in preparing a written plan for a proposed nuclear organization and administration. The purpose of the Workbook is to guide the NRC reviewer through a systematic review and assessment of a proposed organization and administration. It is the NRC's intention to incorporate these Guidelines and Workbook into a future revision of the Standard Review Plan (SRP), NUREG-0800. However, at this time the report is being published so that the material may be used on a voluntary basis by industry to systematically prepare or evaluate their organization or administration plans. Use of the report by the NRC would not occur until after it has been incorporated in the SRP

  14. Assessment of five different guideline indication criteria for spirometry, including modified GOLD criteria, in order to detect COPD: data from 5,315 subjects in the PLATINO study

    OpenAIRE

    Luize, Ana P; Menezes, Ana Maria B.; Perez-Padilla, Rogelio; Muiño, Adriana; López, Maria Victorina; Valdivia, Gonzalo; Lisboa, Carmem; Montes de Oca, Maria; Tálamo, Carlos; Celli, Bartolomé; Oliver A Nascimento; Gazzotti, Mariana R; José R Jardim

    2014-01-01

    Background: Spirometry is the gold standard for diagnosing chronic obstructive pulmonary disease (COPD). Although there are a number of different guideline criteria for deciding who should be selected for spirometric screening, to date it is not known which criteria are the best based on sensitivity and specificity. Aims: Firstly, to evaluate the proportion of subjects in the PLATINO Study that would be recommended for spirometry testing according to Global initiative for Obstructive Lung Dis...

  15. How Severely Is DNA Quantification Hampered by RNA Co-extraction?

    Science.gov (United States)

    Sanchez, Ignacio; Remm, Matthieu; Frasquilho, Sonia; Betsou, Fay; Mathieson, William

    2015-10-01

    The optional RNase digest that is part of many DNA extraction protocols is often omitted, either because RNase is not provided in the kit or because users do not want to risk contaminating their laboratory. Consequently, co-eluting RNA can become a "contaminant" of unknown magnitude in a DNA extraction. We extracted DNA from liver, lung, kidney, and heart tissues and established that 28-52% of the "DNA" as assessed by spectrophotometry is actually RNA (depending on tissue type). Including an RNase digest in the extraction protocol reduced 260:280 purity ratios. Co-eluting RNA drives an overestimation of DNA yield when quantification is carried out using OD 260 nm spectrophotometry, or becomes an unquantified contaminant when spectrofluorometry is used for DNA quantification. This situation is potentially incompatible with the best practice guidelines for biobanks issued by organizations such as the International Society for Biological and Environmental Repositories, which state that biospecimens should be accurately characterized in terms of their identity, purity, concentration, and integrity. Consequently, we conclude that an RNase digest must be included in DNA extractions if pure DNA is required. We also discuss the implications of unquantified RNA contamination in DNA samples in the context of laboratory accreditation schemes. PMID:26418169

  16. IAEA-TECDOC ASSET Guidelines

    International Nuclear Information System (INIS)

    The ASSET programme provides an international mechanism for determining procedures to prevent incidents and accidents in nuclear facilities. The programme deals with, and critically assesses, analyses of incidents and accidents, provides instructions at a general level and gives suggestions and recommendations aimed at increasing the operating nuclear safety standard. ASSET guidelines and regulations are intended to ensure consistency in the application of the team's analytical methods. They serve systematic inspection and help gaining insight into any relevant problem. (M.D.). Diagrams

  17. Cost analysis guidelines

    International Nuclear Information System (INIS)

    The first phase of the Depleted Uranium Hexafluoride Management Program (Program)--management strategy selection--consists of several program elements: Technology Assessment, Engineering Analysis, Cost Analysis, and preparation of an Environmental Impact Statement (EIS). Cost Analysis will estimate the life-cycle costs associated with each of the long-term management strategy alternatives for depleted uranium hexafluoride (UF6). The scope of Cost Analysis will include all major expenditures, from the planning and design stages through decontamination and decommissioning. The costs will be estimated at a scoping or preconceptual design level and are intended to assist decision makers in comparing alternatives for further consideration. They will not be absolute costs or bid-document costs. The purpose of the Cost Analysis Guidelines is to establish a consistent approach to analyzing of cost alternatives for managing Department of Energy's (DOE's) stocks of depleted uranium hexafluoride (DUF6). The component modules that make up the DUF6 management program differ substantially in operational maintenance, process-options, requirements for R and D, equipment, facilities, regulatory compliance, (O and M), and operations risk. To facilitate a consistent and equitable comparison of costs, the guidelines offer common definitions, assumptions or basis, and limitations integrated with a standard approach to the analysis. Further, the goal is to evaluate total net life-cycle costs and display them in a way that gives DOE the capability to evaluate a variety of overall DUF6 management strategies, including commercial potential. The cost estimates reflect the preconceptual level of the designs. They will be appropriate for distinguishing among management strategies

  18. Volumetric motion quantification by 3D tissue phase mapped CMR

    OpenAIRE

    Lutz Anja; Paul Jan; Bornstedt Axel; Nienhaus G; Etyngier Patrick; Bernhardt Peter; Rottbauer Wolfgang; Rasche Volker

    2012-01-01

    Abstract Background The objective of this study was the quantification of myocardial motion from 3D tissue phase mapped (TPM) CMR. Recent work on myocardial motion quantification by TPM has been focussed on multi-slice 2D acquisitions thus excluding motion information from large regions of the left ventricle. Volumetric motion assessment appears an important next step towards the understanding of the volumetric myocardial motion and hence may further improve diagnosis and treatments in patien...

  19. Quantification of global myocardial oxygenation in humans: initial experience

    OpenAIRE

    Gropler Robert J; Woodard Pamela K; Lyons Matt; Lesniak Donna; O'Connor Robert; McCommis Kyle S; Zheng Jie

    2010-01-01

    Abstract Purpose To assess the feasibility of our newly developed cardiovascular magnetic resonance (CMR) methods to quantify global and/or regional myocardial oxygen consumption rate (MVO2) at rest and during pharmacologically-induced vasodilation in normal volunteers. Methods A breath-hold T2 quantification method is developed to calculate oxygen extraction fraction (OEF) and MVO2 rate at rest and/or during hyperemia, using a two-compartment model. A previously reported T2 quantification me...

  20. Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008

    DEFF Research Database (Denmark)

    Brüggemann, M; Schrauder, A; Raff, T;

    2010-01-01

    assessment was built in the context of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. The panel summarized the current state of MRD diagnostics in ALL and developed recommendations on the minimal technical requirements that should be fulfilled before...... treatment stratification. Therefore, there is an increasing need for standardization of methodologies and harmonization of terminology. For this purpose, a panel of representatives of all major European study groups on childhood and adult ALL and of international experts on PCR- and flow cytometry-based MRD...

  1. Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008

    DEFF Research Database (Denmark)

    Brüggemann, M; Schrauder, A; Raff, T; Pfeifer, H; Dworzak, M; Ottmann, O G; Asnafi, V; Baruchel, A; Bassan, R; Benoit, Y; Biondi, A; Cavé, H; Dombret, H; Fielding, A K; Foà, R; Gökbuget, N; Goldstone, A H; Goulden, N; Henze, G; Hoelzer, D; Janka-Schaub, G E; Macintyre, E A; Pieters, R; Rambaldi, A; Ribera, J-M; Schmiegelow, K; Spinelli, O; Stary, J; von Stackelberg, A; Kneba, M; Schrappe, M; van Dongen, J J M

    2010-01-01

    Assessment of minimal residual disease (MRD) has acquired a prominent position in European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the basis of its high prognostic value for predicting outcome and the possibilities for implementation of MRD diagnostics in...... treatment stratification. Therefore, there is an increasing need for standardization of methodologies and harmonization of terminology. For this purpose, a panel of representatives of all major European study groups on childhood and adult ALL and of international experts on PCR- and flow cytometry-based MRD...... assessment of response to treatment in adult and childhood ALL, and provides a sound basis for the comparison of MRD results between different treatment protocols....

  2. Agreement between Cochrane Neonatal reviews and clinical practice guidelines for newborns in Denmark a cross sectional study

    DEFF Research Database (Denmark)

    Brok, Jesper; Greisen, Gorm; Madsen, Lars P; Tilma, Karen; Faerk, Jan; Børch, Klaus; Garne, Ester; Christensen, Henrik T; Stanchev, Hristo; Jacobsen, Thorkild; Nielsen, Jens P; Henriksen, Tine Brink; Gluud, Christian

    2007-01-01

    OBJECTIVE: To assess agreement between Cochrane Neonatal Group reviews and clinical practice guidelines in Denmark. DESIGN: Retrospective analysis of clinical guidelines for newborn infants. Materials:All Cochrane neonatal reviews and Danish local clinical guidelines for newborn infants. MAIN OUT...

  3. Public informations guidelines

    Energy Technology Data Exchange (ETDEWEB)

    None

    1986-06-01

    The purpose of these Public Information Guidelines is to provide principles for the implementation of the NWPA mandate and the Mission Plan requirements for the provision of public information. These Guidelines set forth the public information policy to be followed by all Office of Civilian Radioactive Waste Management (OCRWM) performance components. The OCRWM offices should observe these Guidelines in shaping and conducting public information activities.

  4. Public informations guidelines

    International Nuclear Information System (INIS)

    The purpose of these Public Information Guidelines is to provide principles for the implementation of the NWPA mandate and the Mission Plan requirements for the provision of public information. These Guidelines set forth the public information policy to be followed by all Office of Civilian Radioactive Waste Management (OCRWM) performance components. The OCRWM offices should observe these Guidelines in shaping and conducting public information activities

  5. Are Radiation Therapy Oncology Group Para-aortic Contouring Guidelines for Pancreatic Neoplasm Applicable to Other Malignancies—Assessment of Nodal Distribution in Gynecological Malignancies

    International Nuclear Information System (INIS)

    Purpose: Intensity modulated radiation therapy is used to reduce dose to adjacent critical structures while maintaining adequate target coverage, but it requires precise target localization. We report the 3-dimensional distribution of para-aortic (PA) lymph nodes (LN) in pelvic malignancies. We propose a guideline to accurately define the PA LN by anatomic landmarks and compare our data with published guidelines for pancreatic cancer. Methods and Materials: A retrospective analysis was performed on 46 patients with pelvic malignancies and positive PA LNs. Positive LNs were defined based on size and morphology or fluorodeoxyglucose avidity. All PA LNs were characterized into 3 groups based on location: left PA (between aorta and left psoas muscle), aortocaval (between aorta and inferior vena cava), and right paracaval (between inferior vena cava and right psoas muscle). Patients with retrocrural LNs were also analyzed. Results: One hundred thirty-three positive PA LNs were evaluated. The majority of the PA LNs were in the left PA (59%) and aortocaval (35) regions, and only 8% were in the right paracaval region. All patients with positive right paracaval LNs also had involved left PA LNs, with only 1 exception. The highest PA LN involvement was at the level of the renal vessels and was seen in 28% of patients. Of these patients with disease extending to renal vessels, 38% had retrocrural LN involvement. Conclusions: The nodal contouring for the PA region should not be defined by a fixed circumferential margin around the vessels. The left PA and aortocaval spaces should be covered adequately because these are common locations of PA LNs. For microscopic disease superiorly, contouring should extend up to renal vessels rather than a fixed bony landmark. For patients who have nodal involvement at renal vessels, one can consider including retrocrural LNs. Radiation Therapy Oncology Group Para-aortic Contouring Guidelines for Pancreatic Neoplasm are not applicable to

  6. Industry guidelines for the calibration of maximum anemometers

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, B.H. [AWS Scientific, Inc., Albany, NY (United States)

    1996-12-31

    The purpose of this paper is to report on a framework of guidelines for the calibration of the Maximum Type 40 anemometer. This anemometer model is the wind speed sensor of choice in the majority of wind resource assessment programs in the U.S. These guidelines were established by the Utility Wind Resource Assessment Program. In addition to providing guidelines for anemometers, the appropriate use of non-calibrated anemometers is also discussed. 14 refs., 1 tab.

  7. Clinical Practice Guidelines for Coma Management

    OpenAIRE

    Julio Alonso Cortizo Hernández; Maribel Misas Menéndez; Zenia Lisset Hernández Millán; Diosdania Alfonso Falcón; Tania Pérez Ramos

    2009-01-01

    Clinical Practice Guidelines for Coma Management. It has been defined as acute alteration of wakefulness state, in which patients have a primitive response (or no response at all) to nociceptive stimulus without waking up and could reach the total absence of all reflex. This document includes a review and update of the main clinical aspects, concepts, aetiology and therapy for this condition. It includes assessment guidelines focused on the most important aspects to be accomplished.

  8. Clinical Practice Guidelines for Cardiogenic Shock.

    Directory of Open Access Journals (Sweden)

    Arelys Falcón Hernández

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Cardiogenic Shock. It has been defined as the persistence of tissue hypoperfusion, usually associated to blood hypotension as the result of heart pumping failure. This document includes a review of the main aspects as concepts, aetiology, diagnosis and treatment. It includes the concept, risk factors, clinical presentations, diagnosis, and therapy based on the possibilities of our environment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  9. Clinical Practice Guidelines for Pulmonary Thromboembolism.

    OpenAIRE

    Aymara Marcia Hernández Cardoso; Maribel Misas Menéndez; Carlos Jaime Geroy Gómez; Diosdania Alfonso Falcón

    2009-01-01

    Clinical Practice Guidelines for Pulmonary Thromboembolism. This condition is caused by the obstruction of pulmonary arterial circulation as a result of an embolus originated in the profound venous system of the in the lower extremities (95%). It includes the concept, risk factors, clinical presentations, diagnosis, and therapy based on the possibilities of our environment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  10. Clinical Practice Guidelines for Hypertensive Emergency Treatment

    OpenAIRE

    Carlos Garcia Gomez; Raúl Nieto Cabrera

    2009-01-01

    Clinical Practice Guidelines for Hypertensive Emergency Treatment. It has been defined as the abrupt increase of systolic and diastolic blood pressure (usually ≥ 220/140 mmHg) associated with organic damage mainly of the central nervous system, heart or kidneys. This document includes concepts, different presentations, diagnosis and treatment, stressing the function of the most frequent hypotensive medications. It includes assessment guidelines focused on the most important aspects to be acco...

  11. Clinical Practice Guidelines for Cerebral Abscess Treatment

    OpenAIRE

    Danny Barrueta Reyes; Néstor Pulido Ríos

    2009-01-01

    Clinical Practice Guidelines for Cerebral Abscess Treatment. It has been defined as a festering process caused by any germ and placed inside the cerebral parenchyma; this is a diagnostic and therapeutic challenge for surgeons and general doctors since the clinical and radiological manifestations are often imprecise. This document describes its etiological agents, clinical presentation, diagnosis and treatment. It includes assessment guidelines focused on the most important aspects to be accom...

  12. Clinical Practice Guidelines for Acute Myocardial Infarction.

    OpenAIRE

    Francisco de Jesús Valladares Carvajal; Arelys Falcón Hernández; Félix Rolando Jorrín Román; Juan Emilio García Rivas

    2009-01-01

    Clinical Practice Guidelines for Acute Myocardial Infarction. It has been defined as the clinical condition caused by the ischemic myocardial necrosis, usually caused by abrupt reduction of coronary blood irrigation affecting one or more myocardial areas. The document includes a review and update of the concept, classification, diagnosis and therapy. Risk stratification and main aspects of rehabilitation are also stressed. It includes assessment guidelines focused on the most important aspect...

  13. Clinical Practice Guidelines for Herniated Disk Treatment

    OpenAIRE

    José Ramón Tejera del Valle; Joaquín Aguilar Trujillo; Danny Barrueta Reyes; José Gómez Cruz; Líder Tejera Sánchez

    2009-01-01

    Clinical Practice Guidelines for Herniated Disk Treatment. The current concept is not only limited to the disorder caused by the rupture of the intervertebral disk, it also includes primary disk degeneration and the resulting spondylosis, and disk disorders associated with this degeneration, traumas and aseptic and granulomatous discitis. Concept, diagnosis, treatment and aetiology are defined and commented stressing the neurosurgical aspects. It includes assessment guidelines focused on the ...

  14. Clinical Practice Guidelines for Acute Renal Failure.

    OpenAIRE

    Argelio Alberto Santana Cano; Marta Patricia Casanova González; Belkys Rodríguez Llerena.; Eddy Pereira Valdés

    2009-01-01

    Clinical Practice Guidelines for Acute Renal Failure. It a syndrome characterized by the abrupt deterioration of basal renal functions (abrupt reduction of glomerular filtration) and the consequent increase of nitrogenous products in the blood as well as the homeostasis of the body. It aetiological agents, clinical presentation, therapeutic and diagnostic methods are described. It includes assessment guidelines focused on the most important aspects to be accomplished.

  15. Clinical Practice Guidelines for Cerebral Abscess Treatment

    Directory of Open Access Journals (Sweden)

    Danny Barrueta Reyes

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Cerebral Abscess Treatment. It has been defined as a festering process caused by any germ and placed inside the cerebral parenchyma; this is a diagnostic and therapeutic challenge for surgeons and general doctors since the clinical and radiological manifestations are often imprecise. This document describes its etiological agents, clinical presentation, diagnosis and treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  16. Clinical Practice Guidelines for Severe Sepsis Treatment.

    OpenAIRE

    Julio Héctor Jova Dueñas; Diosdania Alfonso Falcón; Marcos Diosdado Iraola Ferrer; Inti Santana Carballosa; José Noel Marrero.

    2009-01-01

    Clinical Practice Guidelines for Severe Sepsis Treatment. It is a syndrome of inflammatory systemic response caused by documented infection (clinical and/or microbiological), associated with organic dysfunction (respiratory, renal, hepatic, cardiovascular, haematological and neurological), hypotension or hypoperfusion. This document includes a review and update of the concept, risk factors, diagnosis and treatment. It includes assessment guidelines focused on the most important aspects to be ...

  17. Clinical Practice Guidelines for Acute Renal Failure.

    Directory of Open Access Journals (Sweden)

    Argelio Alberto Santana Cano

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Acute Renal Failure. It a syndrome characterized by the abrupt deterioration of basal renal functions (abrupt reduction of glomerular filtration and the consequent increase of nitrogenous products in the blood as well as the homeostasis of the body. It aetiological agents, clinical presentation, therapeutic and diagnostic methods are described. It includes assessment guidelines focused on the most important aspects to be accomplished.

  18. Clinical Practice Guidelines for Acute Myocardial Infarction.

    Directory of Open Access Journals (Sweden)

    Francisco De Jesús Valladares Carvajal

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Acute Myocardial Infarction. It has been defined as the clinical condition caused by the ischemic myocardial necrosis, usually caused by abrupt reduction of coronary blood irrigation affecting one or more myocardial areas. The document includes a review and update of the concept, classification, diagnosis and therapy. Risk stratification and main aspects of rehabilitation are also stressed. It includes assessment guidelines focused on the most important aspects to be accomplished.

  19. Quantification of beta-cell function during IVGTT in Type II and non-diabetic subjects: assessment of insulin secretion by mathematical methods

    DEFF Research Database (Denmark)

    Kjems, L L; Vølund, A; Madsbad, Sten

    2001-01-01

    AIMS/HYPOTHESIS: We compared four methods to assess their accuracy in measuring insulin secretion during an intravenous glucose tolerance test in patients with Type II (non-insulin-dependent) diabetes mellitus and with varying beta-cell function and matched control subjects. METHODS: Eight control...... subjects and eight Type II diabetic patients underwent an intravenous glucose tolerance test with tolbutamide and an intravenous bolus injection of C-peptide to assess C-peptide kinetics. Insulin secretion rates were determined by the Eaton deconvolution (reference method), the Insulin SECretion method...... first-phase insulin response (r = 0.78). The two-compartment combined model failed to provide reliable estimates of insulin secretion in three of the control subjects and in two patients with Type II diabetes. The four methods were accurate with respect to mean basal and first-phase secretion response...

  20. Spatial Quantification of Non-Point Source Pollution in a Meso-Scale Catchment for an Assessment of Buffer Zones Efficiency

    OpenAIRE

    Mikołaj Piniewski; Paweł Marcinkowski; Ignacy Kardel; Marek Giełczewski; Katarzyna Izydorczyk; Wojciech Frątczak

    2015-01-01

    The objective of this paper was to spatially quantify diffuse pollution sources and estimate the potential efficiency of applying riparian buffer zones as a conservation practice for mitigating chemical pollutant losses. This study was conducted using a semi-distributed Soil and Water Assessment Tool (SWAT) model that underwent extensive calibration and validation in the Sulejów Reservoir catchment (SRC), which occupies 4900 km2 in central Poland. The model was calibrated and validated agains...

  1. 12 CFR Appendix B to Part 570 - Interagency Guidelines Establishing Information Security Standards

    Science.gov (United States)

    2010-01-01

    ... customer. B. Risk Assessment and Controls 1. The Security Guidelines direct every financial institution to... See Security Guidelines, III.B. 2. Following the assessment of these risks, the Security Guidelines.... 1, 2001; FDIC FIL 68-99, Risk Assessment Tools and Practices for Information System Security, July...

  2. Canine mammary tumors: a review and consensus of standard guidelines on epithelial and myoepithelial phenotype markers, HER2, and hormone receptor assessment using immunohistochemistry.

    Science.gov (United States)

    Peña, L; Gama, A; Goldschmidt, M H; Abadie, J; Benazzi, C; Castagnaro, M; Díez, L; Gärtner, F; Hellmén, E; Kiupel, M; Millán, Y; Miller, M A; Nguyen, F; Poli, A; Sarli, G; Zappulli, V; de las Mulas, J Martín

    2014-01-01

    Although there have been several studies on the use of immunohistochemical biomarkers of canine mammary tumors (CMTs), the results are difficult to compare. This article provides guidelines on the most useful immunohistochemical markers to standardize their use and understand how outcomes are measured, thus ensuring reproducibility of results. We have reviewed the biomarkers of canine mammary epithelial and myoepithelial cells and identified those biomarkers that are most useful and those biomarkers for invasion and lymph node micrometastatic disease. A 10% threshold for positive reaction for most of these markers is recommended. Guidelines on immunolabeling for HER2, estrogen receptors (ERs), and progesterone receptors (PRs) are provided along with the specific recommendations for interpretation of the results for each of these biomarkers in CMTs. Only 3+ HER2-positive tumors should be considered positive, as found in human breast cancer. The lack of any known response to adjuvant endocrine therapy of ER- and PR-positive CMTs prevents the use of the biological positive/negative threshold used in human breast cancer. Immunohistochemistry results of ER and PR in CMTs should be reported as the sum of the percentage of positive cells and the intensity of immunolabeling (Allred score). Incorporation of these recommendations in future studies, either prospective or retrospective, will provide a mechanism for the direct comparison of studies and will help to determine whether these biomarkers have prognostic significance. Finally, these biomarkers may ascertain the most appropriate treatment(s) for canine malignant mammary neoplasms. PMID:24227007

  3. Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with 99mTc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice

    Science.gov (United States)

    Zhang, Deliang; Guo, Zhide; Zhang, Pu; Li, Yesen; Su, Xinhui; You, Linyi; Gao, Mengna; Liu, Chang; Wu, Hua; Zhang, Xianzhong

    2016-01-01

    The goal of this study is to develop a noninvasive method of SPECT imaging to quantify and stage liver fibrosis with an Asialoglycoprotein receptor (ASGP-R) targeting tracer—99mTc-p(VLA-co-VNI). ASGP-Rs are well known to specifically express in the mammalian liver. Here, we demonstrated ASGP-R expression decreased in carbon tetrachloride (CCl4)-induced mouse model. ASGP-R expression correlated with liver fibrosis progression. ASGP-R could be a useful marker in the stage of liver fibrosis. Liver uptake value (LUV) derived by SPECT imaging was used to assess liver fibrosis in the CCl4-induced mouse model. LUV = [radioactivity (liver uptake)/radioactivity (injected)] × 100/liver volume. The LUV decreased along with the disease progression. The relationships between LUV and liver hydroxyproline (i.e. collagen), as well as Sirius Red were established and verified. A strong negative linear correlation was found between LUV and hydroxyproline levels (r = −0.83) as well as LUV and Sirius Red quantification (r = −0.83). In conclusion, SPECT imaging with 99mTc-p(VLA-co-VNI) is useful in evaluating and staging liver fibrosis in vivo. PMID:27150943

  4. Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice.

    Science.gov (United States)

    Zhang, Deliang; Guo, Zhide; Zhang, Pu; Li, Yesen; Su, Xinhui; You, Linyi; Gao, Mengna; Liu, Chang; Wu, Hua; Zhang, Xianzhong

    2016-01-01

    The goal of this study is to develop a noninvasive method of SPECT imaging to quantify and stage liver fibrosis with an Asialoglycoprotein receptor (ASGP-R) targeting tracer-(99m)Tc-p(VLA-co-VNI). ASGP-Rs are well known to specifically express in the mammalian liver. Here, we demonstrated ASGP-R expression decreased in carbon tetrachloride (CCl4)-induced mouse model. ASGP-R expression correlated with liver fibrosis progression. ASGP-R could be a useful marker in the stage of liver fibrosis. Liver uptake value (LUV) derived by SPECT imaging was used to assess liver fibrosis in the CCl4-induced mouse model. LUV = [radioactivity (liver uptake)/radioactivity (injected)] × 100/liver volume. The LUV decreased along with the disease progression. The relationships between LUV and liver hydroxyproline (i.e. collagen), as well as Sirius Red were established and verified. A strong negative linear correlation was found between LUV and hydroxyproline levels (r = -0.83) as well as LUV and Sirius Red quantification (r = -0.83). In conclusion, SPECT imaging with (99m)Tc-p(VLA-co-VNI) is useful in evaluating and staging liver fibrosis in vivo. PMID:27150943

  5. A quantification of damage and assessment of economic loss due to crop raiding by Asian Elephant Elephas maximus (Mammalia: Proboscidea: Elephantidae: a case study of Manas National Park, Assam, India

    Directory of Open Access Journals (Sweden)

    Naba K. Nath

    2015-02-01

    Full Text Available A study was carried out in Manas National Park, Assam in northeastern India between 2007 and 2009 to understand the magnitude of human-elephant conflict through a quantification of damage and assessment of economic loss. A cluster of six villages adjacent to the Park was selected for this study. Five major agricultural crops were grown during the study period of which three were raided by elephants: winter paddy, autumn paddy and pulses. Paddy was the principle crop central to the farmers’ subsistence. Winter paddy was the most cultivated crop and autumn paddy was the least cultivated. The incidence rate of crop raiding was highest for autumn paddy and lowest for pulses. Overall economic loss due to crop raiding was negligible, however at the individual farmer level, it was quite high. The study revealed that human-elephant conflict is not so severe, indicating ample opportunity for human-elephant coexistence in the region. Crop fields adjacent to the Park were particularly vulnerable to crop raiding which necessitates creation of a buffer zone. The frequency of raiding and the extent of damage was found to be significantly less in crop fields which were guarded by farmers. This was due to traditional crop guarding practices being followed in the region, the strengthening of which could effectively reduce annual crop loss and thus human-elephant conflict could be minimized to a large extent.

  6. The European society of human reproduction and embryology guideline for the diagnosis and treatment of endometriosis: an electronic guideline implementability appraisal

    OpenAIRE

    De Sutter Petra; Simons Arnold HM; Nygren Karl G; Bergh Christina; Hermens Rosella PMG; Dunselman Gerard AJ; D'Hooghe Thomas M; Nelen Willianne LDM; van Dijk Lotte JEW; Marshall Catherine; Burgers Jako S; Kremer Jan AM

    2011-01-01

    Abstract Background Clinical guidelines are intended to improve healthcare. However, even if guidelines are excellent, their implementation is not assured. In subfertility care, the European Society of Human Reproduction and Embryology (ESHRE) guidelines have been inventoried, and their methodological quality has been assessed. To improve the impact of the ESHRE guidelines and to improve European subfertility care, it is important to optimise the implementability of guidelines. We therefore i...

  7. ASVCP guidelines: allowable total error guidelines for biochemistry.

    Science.gov (United States)

    Harr, Kendal E; Flatland, Bente; Nabity, Mary; Freeman, Kathleen P

    2013-12-01

    As all laboratory equipment ages and contains components that may degrade with time, initial and periodically scheduled performance assessment is required to verify accurate and precise results over the life of the instrument. As veterinary patients may present to general practitioners and then to referral hospitals (both of which may each perform in-clinic laboratory analyses using different instruments), and given that general practitioners may send samples to reference laboratories, there is a need for comparability of results across instruments and methods. Allowable total error (TEa ) is a simple comparative quality concept used to define acceptable analytical performance. These guidelines are recommendations for determination and interpretation of TEa for commonly measured biochemical analytes in cats, dogs, and horses for equipment commonly used in veterinary diagnostic medicine. TEa values recommended herein are aimed at all veterinary settings, both private in-clinic laboratories using point-of-care analyzers and larger reference laboratories using more complex equipment. They represent the largest TEa possible without generating laboratory variation that would impact clinical decision making. TEa can be used for (1) assessment of an individual instrument's analytical performance, which is of benefit if one uses this information during instrument selection or assessment of in-clinic instrument performance, (2) Quality Control validation, and (3) as a measure of agreement or comparability of results from different laboratories (eg, between the in-clinic analyzer and the reference laboratory). These guidelines define a straightforward approach to assessment of instrument analytical performance. PMID:24320779

  8. Severe accident management guidelines tool

    International Nuclear Information System (INIS)

    Severe Accident is addressed by means of a great number of documents such as guidelines, calculation aids and diagnostic trees. The response methodology often requires the use of several documents at the same time while Technical Support Centre members need to assess the appropriate set of equipment within the adequate mitigation strategies. In order to facilitate the response, TECNATOM has developed SAMG TOOL, initially named GGAS TOOL, which is an easy to use computer program that clearly improves and accelerates the severe accident management. The software is designed with powerful features that allow the users to focus on the decision-making process. Consequently, SAMG TOOL significantly improves the severe accident training, ensuring a better response under a real situation. The software is already installed in several Spanish Nuclear Power Plants and trainees claim that the methodology can be followed easier with it, especially because guidelines, calculation aids, equipment information and strategies availability can be accessed immediately (authors)

  9. Measure Guideline: Ventilation Cooling

    Energy Technology Data Exchange (ETDEWEB)

    Springer, D.; Dakin, B.; German, A.

    2012-04-01

    The purpose of this measure guideline on ventilation cooling is to provide information on a cost-effective solution for reducing cooling system energy and demand in homes located in hot-dry and cold-dry climates. This guideline provides a prescriptive approach that outlines qualification criteria, selection considerations, and design and installation procedures.

  10. Maintenance Trades Guidelines

    Science.gov (United States)

    Weidner, Theodore J.

    2008-01-01

    In 2002, APPA published "Maintenance Staffing Guidelines for Educational Facilities," the first building maintenance trades staffing guideline designed to assist educational facilities professionals with their staffing needs. addresses how facilities professionals can determine the appropriate size and mix of their organization. Contents include…

  11. D 59 Design Guidelines

    DEFF Research Database (Denmark)

    Burcharth, Hans F.; Lamberti, Alberto

    The present guidelines are specifically dedicated to Low Crested Structures on attempt to provide methodological tools both for the engineering design of structures and for prediction of performance and environmental impacts. It is anticipated that the guidelines will provide valuable inputs to c...

  12. Measure Guideline: Ventilation Cooling

    Energy Technology Data Exchange (ETDEWEB)

    Springer, D. [Alliance for Residential Building Innovation (ARBI), David, CA (United States); Dakin, B. [Alliance for Residential Building Innovation (ARBI), David, CA (United States); German, A. [Alliance for Residential Building Innovation (ARBI), David, CA (United States)

    2012-04-01

    The purpose of this measure guideline is to provide information on a cost-effective solution for reducing cooling system energy and demand in homes located in hot-dry and cold-dry climates. This guideline provides a prescriptive approach that outlines qualification criteria, selection considerations, and design and installation procedures.

  13. Primary care guidelines

    DEFF Research Database (Denmark)

    Ijäs, Jarja; Alanen, Seija; Kaila, Minna;

    2009-01-01

    OBJECTIVE: To describe the adoption of the national Hypertension Guideline in primary care and to evaluate the consistency of the views of the health centre senior executives on the guideline's impact on clinical practices in the treatment of hypertension in their health centres. DESIGN: A cross...

  14. Quantification of intracranial internal carotid artery calcification on brain unenhanced CT: evaluation of its feasibility and assessment of the reliability of visual grading scales

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Sung Soo; Lee, Seung-Koo [Yonsei University College of Medicine, Department of Radiology and the Research Institute of Radiological Science, Seoul (Korea, Republic of); Nam, Hyo Suk; Heo, Ji Hoe; Kim, Young Dae [Yonsei University College of Medicine, Department of Neurology, Seoul (Korea, Republic of); Han, Kyunghwa [Yonsei University College of Medicine, Biostatistics Collaboration Unit, Medical Research Center, Seoul (Korea, Republic of); Kim, Eung Yeop [Yonsei University College of Medicine, Department of Radiology and the Research Institute of Radiological Science, Seoul (Korea, Republic of); Yonsei University College of Medicine, Department of Radiology, Seoul (Korea, Republic of)

    2013-01-15

    Previous studies have evaluated intracranial internal carotid artery calcifications (ICACs) qualitatively using different visual grading scales, which could lead to inconsistent results. The purpose of this study was to evaluate the feasibility of ICAC volume measurement and to correlate the volume with visual grading scales. We included 49 patients (>50 years) who underwent unenhanced cranial CT. Two observers evaluated four visual grading scales and measured ICAC volumes semi-automatically, and interobserver agreements were assessed. Differences in ICAC volume between visual grades of each scale were tested. The relationship between the visual grading and volume was assessed. Interobserver agreements ranged from 0.841 to 0.901 for visual grading and 0.997 for volume measurement. Mean volumes were not significantly different between the visual grades (P > 0.05) except when comparing grade 4 with the other grades. The grades of each visual grading correlated well with ICAC volumes (Spearman's {rho} = 0.849-0.881, P < 0.001). The relationship between the visual grades and volume was described by a quadratic model (R {sup 2}, 0.31-0.50, P < 0.01). ICAC volume measurement is feasible and reproducible, whereas visual grades poorly reflect the actual volume; therefore, volume measurement may be warranted for future research. (orig.)

  15. Quantification of intracranial internal carotid artery calcification on brain unenhanced CT: evaluation of its feasibility and assessment of the reliability of visual grading scales

    International Nuclear Information System (INIS)

    Previous studies have evaluated intracranial internal carotid artery calcifications (ICACs) qualitatively using different visual grading scales, which could lead to inconsistent results. The purpose of this study was to evaluate the feasibility of ICAC volume measurement and to correlate the volume with visual grading scales. We included 49 patients (>50 years) who underwent unenhanced cranial CT. Two observers evaluated four visual grading scales and measured ICAC volumes semi-automatically, and interobserver agreements were assessed. Differences in ICAC volume between visual grades of each scale were tested. The relationship between the visual grading and volume was assessed. Interobserver agreements ranged from 0.841 to 0.901 for visual grading and 0.997 for volume measurement. Mean volumes were not significantly different between the visual grades (P > 0.05) except when comparing grade 4 with the other grades. The grades of each visual grading correlated well with ICAC volumes (Spearman's ρ = 0.849-0.881, P 2, 0.31-0.50, P < 0.01). ICAC volume measurement is feasible and reproducible, whereas visual grades poorly reflect the actual volume; therefore, volume measurement may be warranted for future research. (orig.)

  16. Dam safety operating guidelines

    International Nuclear Information System (INIS)

    As part of Ontario Hydro's dam structure assessment program, the hydraulic design review of several river systems has revealed that many existing dam sites, under current operating procedures, would not have sufficient discharge capacity to pass the Inflow Design Flood (IDF) without compromising the integrity of the associated structures. Typical mitigative measures usually considered in dealing with these dam sites include structural alterations, emergency action plans and/or special operating procedures designed for extreme floods. A pilot study was carried out for the Madawaska River system in eastern Ontario, which has seven Ontario Hydro dam sites in series, to develop and evaluate the effectiveness of the Dam Safety Operating Guidelines (DSOG). The DSOG consist of two components: the flood routing schedules and the minimum discharge schedules, the former of which would apply in the case of severe spring flood conditions when the maximum observed snowpack water content and the forecast rainfall depth exceed threshold values. The flood routing schedules would identify to the operator the optimal timing and/or extent of utilizing the discharge facilities at each dam site to minimize the potential for dam failures cased by overtopping anywhere in the system. It was found that the DSOG reduced the number of structures overtopped during probable maximum flood from thirteen to four, while the number of structures that could fail would be reduced from seven to two. 8 refs., 4 figs., 3 tabs

  17. Wind and tornado guidelines

    International Nuclear Information System (INIS)

    The objective of the Department of Energy Natural Phenomena Hazards Project is to provide guidance and criteria for design of new facilities and for evaluation of existing ones subjected to extreme winds, earthquakes, and floods. This paper describes the treatment of wind and tornado hazards. Four facility-use categories are defined which represent increasing levels of risk to personnel or the environment in the event of a high wind event. Facilities are assigned to a particular category, depending on their mission, value, or toxic material content. The assigned facility-use category determines the design and evaluation criteria. The criteria are based on probabilistic hazard assessment. Performance goals are also specified for each facility-use category. A uniform approach to design wind loads, based on the ANSI A58.1-1982 standard, allows treatment of high winds and hurricane and tornado winds in a similar manner. Based on the wind hazard models, some sites must account for the possibility of tornadoes while others do not. Atmospheric pressure changes and missiles must be taken into account when considering tornadoes. The design and evaluation guidelines are designed to establish consistent levels of risk for different natural phenomena hazards and for facilities at different geographical locations

  18. Risk assessment guidelines of automobile steering system defects and automobile recall cases%汽车转向系统缺陷风险评估准则与汽车召回案例

    Institute of Scientific and Technical Information of China (English)

    张卫亮; 肖凌云; 刘亚辉

    2013-01-01

    Automobile steering system defects affect the automobile safety, and are important causes of automobile-recal . Risk assessment guidelines were proposed for automobile steering system defects to improve the manage efifciency of automobile recal , based on risk matrix and risk level after analyzed automobile steering system failure forms and their inlfuence. Automobile recal cases caused by steering system defects were analyzed using the risk assessment guidelines. The results show that the defect risk matrix method can identify steering system defects and evaluate the risk level. Therefore, the defect risk assessment guidelines can assess the automobile steering system defects risk and automobile recal , also can be extended to other defects of automobile, and enhance the process of automobile recal .%汽车转向系统缺陷严重影响汽车的行驶安全性,是汽车召回的重要原因之一。为了提高汽车召回的管理效率,该文分析了汽车转向系统故障缺陷的形式及其影响,以风险矩阵法和风险等级为依据,提出了一种汽车转向系统缺陷风险评估准则。以此分析了汽车被召回的案例。结果表明:本文的风险矩阵法,能识别转向系统缺陷,并评估其风险。因此,本汽车转向系统缺陷风险评估准则,能指导汽车转向系统缺陷的风险评估和汽车召回,也可扩展到汽车其他缺陷的风险评估中,服务于汽车召回。

  19. Global Imaging referral guidelines

    International Nuclear Information System (INIS)

    The medical imaging specialists called for global referral guidelines which would be made available to referring doctors. These referral guidelines should be:- Applicable in different health care settings, including resource-poor settings; Inclusive in terms of the range of clinical conditions; User-friendly and accessible (format/media); Acceptable to stakeholders, in particular to the referrers as the main target audience. To conceive evidence-based medicine as an integration of best research evidence with clinical expertise and patient values. The Direct recipients of the Referral Guidelines would be:- Referrers: general practitioners / family doctors; paediatricians; emergency department doctors; other specialists and health workers. Providers (medical imaging practitioners): radiologists; nuclear medicine physicians; radiographers; other appropriately qualified practitioners providing diagnostic imaging services. For the Referral Guidelines to be effective there need to be: Credibility evidence-based Practicality end user involvement Context local resources, disease profiles Endorsement, opinion leaders Implementation- policy, education, CPOE - Monitoring of the use clinical audit, report feedback. The aim of the Referral Guidelines Project was to: Produce global referral guidelines that are evidence-based, cost effective and appropriate for the local setting, and include consideration of available equipment and expertise (RGWG; SIGs); Include supporting information about radiation doses, potential risks, protection of children and pregnant women (introductory chapter); Facilitate the implementation of the guidelines through guidance and tools (e.g. implementation guides, checklists, capacity building tools, guides on stakeholders engagement, audit support criteria); Conduct pilot testing in different clinical settings from each of the six WHO regions; Promote the inclusion of the referral guidelines in the curricula of medical schools; Develop and implement

  20. Variation in guideline adherence in intrauterine insemination care.

    Science.gov (United States)

    Haagen, Esther C; Nelen, Willianne L D M; Grol, Richard P T M; Braat, Didi D M; Hermens, Rosella P M G; Kremer, Jan A M

    2010-04-01

    Health-care delivery according to clinical practice guidelines is thought to be critical in achieving optimal outcomes. This study aimed to assess the extent to which practice performance in intrauterine insemination (IUI) care is consistent with guideline recommendations and to evaluate the association between guideline adherence and outcome of IUI care. In a retrospective cohort study, 1100 infertile couples who underwent IUI treatment at 10 Dutch hospitals were asked to grant access to their medical record for assessment of guideline adherence using 25 systematically developed guideline-based performance indicators. A total of 558 couples who started 2334 IUI cycles participated. Guideline adherence regarding 20 process and five structure aspects of IUI care was often substandard and varied considerably between hospitals. Out of 10 possible associations investigated, guideline adherence regarding sperm quality and guideline adherence regarding the total number of IUI cycles were associated with improved ongoing pregnancy rates after IUI. Thus, guideline adherence in IUI care is far from optimal and varies substantially between hospitals. As associations between guideline adherence and ongoing pregnancy after IUI were mainly non-significant, further research is needed to evaluate associations between guideline adherence and other outcomes of IUI care besides ongoing pregnancy, such as patient safety and cost effectiveness. PMID:20129823

  1. Development of a general method for detection and quantification of the P35S promoter based on assessment of existing methods.

    Science.gov (United States)

    Wu, Yuhua; Wang, Yulei; Li, Jun; Li, Wei; Zhang, Li; Li, Yunjing; Li, Xiaofei; Li, Jun; Zhu, Li; Wu, Gang

    2014-01-01

    The Cauliflower mosaic virus (CaMV) 35S promoter (P35S) is a commonly used target for detection of genetically modified organisms (GMOs). There are currently 24 reported detection methods, targeting different regions of the P35S promoter. Initial assessment revealed that due to the absence of primer binding sites in the P35S sequence, 19 of the 24 reported methods failed to detect P35S in MON88913 cotton, and the other two methods could only be applied to certain GMOs. The rest three reported methods were not suitable for measurement of P35S in some testing events, because SNPs in binding sites of the primer/probe would result in abnormal amplification plots and poor linear regression parameters. In this study, we discovered a conserved region in the P35S sequence through sequencing of P35S promoters from multiple transgenic events, and developed new qualitative and quantitative detection systems targeting this conserved region. The qualitative PCR could detect the P35S promoter in 23 unique GMO events with high specificity and sensitivity. The quantitative method was suitable for measurement of P35S promoter, exhibiting good agreement between the amount of template and Ct values for each testing event. This study provides a general P35S screening method, with greater coverage than existing methods. PMID:25483893

  2. MAAP BWR application guidelines

    International Nuclear Information System (INIS)

    The MAAP Thermal-Hydraulic Qualification and Application Project has as its objective to identify those thermal-hydraulic phenomena modeled in MAAP which are important in predicting severe accident sequences, to qualify those models and to provide guidelines for use of the code. This report provides user guidelines for use of the BWR version of MAAP. The report includes a discussion of the important features of the BWR that are modeled in MAAP, the MAAP modeling of phenomena important to predicting severe accidents and user guidelines for several accident sequences

  3. Quantification of years of life lost attributable to chronic air pollution exposure in a health impact assessment: the case of Nantes

    International Nuclear Information System (INIS)

    Background: When French regional planning for air quality first began, exposure-response functions from time-series studies were used to assess the short-term health impact of urban air pollution. The World Health Organisation also suggests that exposure-response functions from cohort studies be taken into account to evaluate the effects of chronic exposure and to quantify the prematurity of deaths related to chronic exposure to air pollution. This work characterizes the long term effects of air pollution in Nantes by considering years of life lost as well as the number of attributable deaths. methods: the study population is classified in birth cohorts. for each cohort, 2 survival curves are built based on current mortality conditions: the first is built for current exposure to air pollution and the second for exposure to a lower reference level of air pollution. The area between the 2 curves represents years of life lost attributable to urban air pollution. results: the estimated number of premature deaths due to air pollution is approximately 56, or about 2% of the deaths of those older than 30 years. The health impact on the Nantes population is estimated at 27.2 years of life lost attributable to urban air pollution in 1999 and 2388.1 years of life lost for the 1999-2008 period. This amounts to a decrease of roughly 4 months in the life expectancy of those aged 30 years. Conclusion: This study, which also identifies and discusses relevant errors and uncertainty, confirmed that air pollution in Nantes has significant health effects and that chronic exposure plays an essential role in this impact. the number of years of life lost and the reduction in life expectancy provide new reasons to reject the assumption that health effects are limited to the premature deaths of terminally-ill people. the expected health gains in Nantes associated with reduced although still moderate air pollution levels are on the same scale as, and possibly better than, those found in 9

  4. A new 2D-based method for myocardial velocity strain and strain rate quantification in a normal adult and paediatric population: assessment of reference values

    Directory of Open Access Journals (Sweden)

    Arcidiacono C

    2009-02-01

    Full Text Available Abstract Background Recent advances in technology have provided the opportunity for off-line analysis of digital video-clips of two-dimensional (2-D echocardiographic images. Commercially available software that follows the motion of cardiac structures during cardiac cycle computes both regional and global velocity, strain, and strain rate (SR. The present study aims to evaluate the clinical applicability of the software based on the tracking algorithm feature (studied for cardiology purposes and to derive the reference values for longitudinal and circumferential strain and SR of the left ventricle in a normal population of children and young adults. Methods 45 healthy volunteers (30 adults: 19 male, 11 female, mean age 37 ± 6 years; 15 children: 8 male, 7 female, mean age 8 ± 2 years underwent transthoracic echocardiographic examination; 2D cine-loops recordings of apical 4-four 4-chamber (4C and 2-chamber (2C views and short axis views were stored for off-line analysis. Computer analyses were performed using specific software relying on the algorithm of optical flow analysis, specifically designed to track the endocardial border, installed on a Windows™ based computer workstation. Inter and intra-observer variability was assessed. Results The feasibility of measurements obtained with tissue tracking system was higher in apical view (100% for systolic events; 64% for diastolic events than in short axis view (70% for systolic events; 52% for diastolic events. Longitudinal systolic velocity decreased from base to apex in all subjects (5.22 ± 1.01 vs. 1.20 ± 0.88; p Values of global systolic SR, both longitudinal and circumferential, were significantly higher in children than in adults (-1.3 ± 0.2, vs. -1.11 ± 0.2, p = 0.006; -1.9 ± 0.6 vs. -1.6 ± 0.5, p = 0.0265, respectively. No significant differences in longitudinal and circumferential systolic velocities were identified for any segment when comparing adults with children. Conclusion

  5. Curriculum Guidelines for Periodontics.

    Science.gov (United States)

    Journal of Dental Education, 1985

    1985-01-01

    Guidelines describe the interrelationships of this and other dental fields, give an overview of the curriculum and its primary educational objectives, and outline the suggested prerequisites, core content, specific behavioral objectives, sequencing, and faculty requirements. (MSE)

  6. London 2012 packaging guidelines

    OpenAIRE

    2013-01-01

    These guidelines are intended to provide supplemental advice to suppliers and licensees regarding the provisions of the LOCOG Sustainable Sourcing Code that relate to packaging design and materials selection.

  7. Electrical safety guidelines

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The Electrical Safety Guidelines prescribes the DOE safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety standards and guidance for DOE installations in order to affect a reduction or elimination of risks associated with the use of electrical energy. The objectives of these guidelines are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  8. OSART guidelines. 1992 edition

    International Nuclear Information System (INIS)

    The IAEA Operational Safety Review Team (OSART) Guidelines provide overall guidance for the experts to ensure the consistency and comprehensiveness of the operational safety review. Specific guidelines are provided as a guide for the systematic review in the following areas important to operational safety: management, organization and administration, training and qualification, operations, maintenance, technical support, radiation protection, chemistry, emergency planning and preparedness. Additional guidance and reference material has been prepared by the IAEA to complement the expertise of the OSART members

  9. Risk Quantification and Evaluation Modelling

    Directory of Open Access Journals (Sweden)

    Manmohan Singh

    2014-07-01

    Full Text Available In this paper authors have discussed risk quantification methods and evaluation of risks and decision parameter to be used for deciding on ranking of the critical items, for prioritization of condition monitoring based risk and reliability centered maintenance (CBRRCM. As time passes any equipment or any product degrades into lower effectiveness and the rate of failure or malfunctioning increases, thereby lowering the reliability. Thus with the passage of time or a number of active tests or periods of work, the reliability of the product or the system, may fall down to a low value known as a threshold value, below which the reliability should not be allowed to dip. Hence, it is necessary to fix up the normal basis for determining the appropriate points in the product life cycle where predictive preventive maintenance may be applied in the programme so that the reliability (the probability of successful functioning can be enhanced, preferably to its original value, by reducing the failure rate and increasing the mean time between failure. It is very important for defence application where reliability is a prime work. An attempt is made to develop mathematical model for risk assessment and ranking them. Based on likeliness coefficient β1 and risk coefficient β2 ranking of the sub-systems can be modelled and used for CBRRCM.Defence Science Journal, Vol. 64, No. 4, July 2014, pp. 378-384, DOI:http://dx.doi.org/10.14429/dsj.64.6366 

  10. Volumetric motion quantification by 3D tissue phase mapped CMR

    Directory of Open Access Journals (Sweden)

    Lutz Anja

    2012-10-01

    Full Text Available Abstract Background The objective of this study was the quantification of myocardial motion from 3D tissue phase mapped (TPM CMR. Recent work on myocardial motion quantification by TPM has been focussed on multi-slice 2D acquisitions thus excluding motion information from large regions of the left ventricle. Volumetric motion assessment appears an important next step towards the understanding of the volumetric myocardial motion and hence may further improve diagnosis and treatments in patients with myocardial motion abnormalities. Methods Volumetric motion quantification of the complete left ventricle was performed in 12 healthy volunteers and two patients applying a black-blood 3D TPM sequence. The resulting motion field was analysed regarding motion pattern differences between apical and basal locations as well as for asynchronous motion pattern between different myocardial segments in one or more slices. Motion quantification included velocity, torsion, rotation angle and strain derived parameters. Results All investigated motion quantification parameters could be calculated from the 3D-TPM data. Parameters quantifying hypokinetic or asynchronous motion demonstrated differences between motion impaired and healthy myocardium. Conclusions 3D-TPM enables the gapless volumetric quantification of motion abnormalities of the left ventricle, which can be applied in future application as additional information to provide a more detailed analysis of the left ventricular function.

  11. Ecologo guidelines spark disagreement

    International Nuclear Information System (INIS)

    Defining what renewable means has been a challenge, but the authors of a new set of guidelines for the Ecologo certification of renewable low-impact electrcity expect after some delay to have the new rules on the street by March 2000.. There was contention in developing the guideline, according to Terra Choice Environmental Services, the company that created and applied criteria for Ecologo certification under the federal government's Environmetal Choice Program. Interim guidleines were developed and have been in place for renewable power since 1996, and have since been used to certify wood-waste biomass, landfill gas, small hydro and wind power plants, in addition to three green power marketing programs. The first draft of the revised guidelines was issued in March. It was one of the harder guidelines to have been worked on because Canadian power producers did not readily agree on what should qualify as renewable, particularly around the whole area of hydro. While small run-of-river hydro plants will continue to fit within the Ecologo guidelines, larger projects will not. Wind power producers are relatively happy with the latest version of TerraChoice's draft guidelines, released at the end of November. A significant revision of the original rules is a limit on the amount of older generation green power marketers who want to promote the green power Ecologo electricity can sell. At least 50% of their capacity must originate from plants installed after January 1, 1991

  12. Guidelines International Network: toward international standards for clinical practice guidelines.

    NARCIS (Netherlands)

    Qaseem, A.; Forland, F.; Macbeth, F.; Ollenschlager, G.; Phillips, S.; Wees, P.J. van der

    2012-01-01

    Guideline development processes vary substantially, and many guidelines do not meet basic quality criteria. Standards for guideline development can help organizations ensure that recommendations are evidence-based and can help users identify high-quality guidelines. Such organizations as the U.S. In

  13. Acute Myocardial Infarction. An Update of the Clinical Practice Guideline

    OpenAIRE

    Yanier Coll Muñoz; Francisco de Jesús Valladares Carvajal; Claudio González Rodríguez

    2016-01-01

    Clinical practice guidelines present all relevant evidence on a particular issue in order to help physicians select the best treatment strategies. This guideline aims to optimize the diagnostic process and treatment of acute myocardial infarction, to assess adherence to issued guidelines and to propose changes based on the results obtained. It refers to patients with ischemic symptoms or their equivalents, persistent ST-segment elevation or ST-segment and T-wave changes consistent with the di...

  14. Introductional presentation of international guidelines for test-use

    Directory of Open Access Journals (Sweden)

    Staša Bučar Markič

    2000-09-01

    Full Text Available The causes for origin, the development the and main structure of the International Guidelines for test-use are presented. They were developed by Dave Bartram for the International Test Commission. The Guidelines should be considered as an aid for developing specific local standards, and to ensure consistency between different countries. The Guidelines are not relevant only for psychological testing, but also for testing in other fields (education, employment etc., as well as for other types of assessment.

  15. Verification& Validation (V&V) Guidelines and Quantitative Reliability at Confidence (QRC): Basis for an Investment Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Logan, R W; Nitta, C K

    2002-07-17

    This paper represents an attempt to summarize our thoughts regarding various methods and potential guidelines for Verification and Validation (V&V) and Uncertainty Quantification (UQ) that we have observed within the broader V&V community or generated ourselves. Our goals are to evaluate these various methods, to apply them to computational simulation analyses, and integrate them into methods for Quantitative Certification techniques for the nuclear stockpile. We describe the critical nature of high quality analyses with quantified V&V, and the essential role of V&V and UQ at specified Confidence levels in evaluating system certification status. Only after V&V has contributed to UQ at confidence can rational tradeoffs of various scenarios be made. UQ of performance and safety margins for various scenarios and issues are applied in assessments of Quantified Reliability at Confidence (QRC) and we summarize with a brief description of how these V&V generated QRC quantities fold into a Value-Engineering methodology for evaluating investment strategies. V&V contributes directly to the decision process for investment, through quantification of uncertainties at confidence for margin and reliability assessments. These contributions play an even greater role in a Comprehensive Test Ban Treaty (CTBT) environment than ever before, when reliance on simulation in the absence of the ability to perform nuclear testing is critical.

  16. Training load quantification in triathlon

    OpenAIRE

    2011-01-01

    There are different Indices of Training Stress of varying complexity, to quantification Training load. Examples include the training impulse (TRIMP), the session (RPE), Lucia’s TRIMP or Summated Zone Score. But the triathlon, a sport to be combined where there are interactions between different segments, is a complication when it comes to quantify the training. The aim of this paper is to review current methods of quantification, and to propose a scale to quantify the training load in triathl...

  17. Quantification of human responses

    Science.gov (United States)

    Steinlage, R. C.; Gantner, T. E.; Lim, P. Y. W.

    1992-01-01

    Human perception is a complex phenomenon which is difficult to quantify with instruments. For this reason, large panels of people are often used to elicit and aggregate subjective judgments. Print quality, taste, smell, sound quality of a stereo system, softness, and grading Olympic divers and skaters are some examples of situations where subjective measurements or judgments are paramount. We usually express what is in our mind through language as a medium but languages are limited in available choices of vocabularies, and as a result, our verbalizations are only approximate expressions of what we really have in mind. For lack of better methods to quantify subjective judgments, it is customary to set up a numerical scale such as 1, 2, 3, 4, 5 or 1, 2, 3, ..., 9, 10 for characterizing human responses and subjective judgments with no valid justification except that these scales are easy to understand and convenient to use. But these numerical scales are arbitrary simplifications of the complex human mind; the human mind is not restricted to such simple numerical variations. In fact, human responses and subjective judgments are psychophysical phenomena that are fuzzy entities and therefore difficult to handle by conventional mathematics and probability theory. The fuzzy mathematical approach provides a more realistic insight into understanding and quantifying human responses. This paper presents a method for quantifying human responses and subjective judgments without assuming a pattern of linear or numerical variation for human responses. In particular, quantification and evaluation of linguistic judgments was investigated.

  18. Nitrogen quantification with SNMS

    Science.gov (United States)

    Goschnick, J.; Natzeck, C.; Sommer, M.

    1999-04-01

    Plasma-based secondary neutral mass spectrometry (plasma SNMS) is a powerful analytical method for determining the elemental concentrations of almost any kind of material at low cost by using a cheap quadrupole mass filter. However, a quadrupole-based mass spectrometer is limited to nominal mass resolution. Atomic signals are sometimes superimposed by molecular signals (2 or 3 atomic clusters such as CH +, CH 2+ or metal oxide clusters) and/or intensities of double-charged species. Especially in the case of nitrogen several interferences can impede the quantification. This article reports on methods to recognize and deconvolute superpositions of N + with CH 2+, Li 2+, and Si 2+ at mass 14 D (Debye) occurring during analysis of organic and inorganic substances. The recognition is based on the signal pattern of N +, Li +, CH +, and Si +. The latter serve as indicators for a probable interference of molecular or double-charged species with N on mass 14 D. The subsequent deconvolution use different shapes of atomic and cluster kinetic energy distributions (kEDs) to determine the quantities of the intensity components by a linear fit of N + and non-atomic kEDs obtained from several organic and inorganic standards into the measured kED. The atomic intensity fraction yields a much better nitrogen concentration than the total intensity of mass 14 D after correction.

  19. Advanced control room design review guidelines: Integration of the NUREG-0700 guidelines and development of new human-system interface guidelines

    International Nuclear Information System (INIS)

    This report documents the work conducted in four tasks of the Nuclear Regulatory Commission (NRC) project entitled Review Criteria for Human Factors Aspects of Advanced Controls and Instrumentation. The purpose of the first task was to integrate the applicable sections of NUREG-0700 into the advanced control room design review (ACRDR) guidelines to ensure that all applicable guidelines are together in one document and conveniently accessible to users. The primary objective of the second task was to formulate a strategy for the development of new ACRDR guidelines that have not otherwise been identified. The main focus of the third task was to modify the individual ACRDR guidelines generated to date to ensure that they are suitable for the intended nuclear power plant (NPP) control station system application. The goal of the fourth task was to develop human factors guidelines for two human-system interface categories that are missing from the current ACRDR guidelines document. During the first task those areas in NUREG-0700 that are not addressed by the ACRDR guidelines document were identified, the areas were subsequently reviewed against six recent industry human factors engineering review guidelines, and the NUREG-0700 guidelines were updated as necessary. In the second task 13 general categories of human-system interface guidelines that are either missing from or not adequately addressed by the ACRDR document were discovered. An approach was derived for the development of new ACRDR guidelines, a preliminary assessment of the available sources that may be useful in the creation of new guidelines and their applicability to the identified human-system interface categories was performed, and an estimate was made of the amount of time and level of effort required to complete the development of needed new ACRDR guidelines. During the third task those NPP control station systems to which the NUREG-0700 and ACRDR guidelines apply were identified, matrices of such

  20. Advanced control room design review guidelines: Integration of the NUREG-0700 guidelines and development of new human-system interface guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Carter, R.J.

    1997-07-01

    This report documents the work conducted in four tasks of the Nuclear Regulatory Commission (NRC) project entitled Review Criteria for Human Factors Aspects of Advanced Controls and Instrumentation. The purpose of the first task was to integrate the applicable sections of NUREG-0700 into the advanced control room design review (ACRDR) guidelines to ensure that all applicable guidelines are together in one document and conveniently accessible to users. The primary objective of the second task was to formulate a strategy for the development of new ACRDR guidelines that have not otherwise been identified. The main focus of the third task was to modify the individual ACRDR guidelines generated to date to ensure that they are suitable for the intended nuclear power plant (NPP) control station system application. The goal of the fourth task was to develop human factors guidelines for two human-system interface categories that are missing from the current ACRDR guidelines document. During the first task those areas in NUREG-0700 that are not addressed by the ACRDR guidelines document were identified, the areas were subsequently reviewed against six recent industry human factors engineering review guidelines, and the NUREG-0700 guidelines were updated as necessary. In the second task 13 general categories of human-system interface guidelines that are either missing from or not adequately addressed by the ACRDR document were discovered. An approach was derived for the development of new ACRDR guidelines, a preliminary assessment of the available sources that may be useful in the creation of new guidelines and their applicability to the identified human-system interface categories was performed, and an estimate was made of the amount of time and level of effort required to complete the development of needed new ACRDR guidelines. During the third task those NPP control station systems to which the NUREG-0700 and ACRDR guidelines apply were identified, matrices of such

  1. An approach to measure compliance to clinical guidelines in psychiatric care

    OpenAIRE

    Brommels Mats; Wistedt Anna; Forsner Tord; Forsell Yvonne

    2008-01-01

    Abstract Background The aim of this study was to measure six months compliance to Swedish clinical guidelines in psychiatric care after an active supported implementation process, using structured measures derived from the guidelines. Methods In this observational study four psychiatric clinics each participated in active implementation of the clinical guidelines for the assessment and treatment of depression and guidelines for assessment and treatment of patients with suicidal behaviours dev...

  2. EM Health and Safety Plan Guidelines

    Energy Technology Data Exchange (ETDEWEB)

    1994-12-01

    This document contains information about the Health and Safety Plan Guidelines. Topics discussed include: Regulatory framework; key personnel; hazard assessment; training requirements; personal protective equipment; extreme temperature disorders or conditions; medical surveillance; exposure monitoring/air sampling; site control; decontamination; emergency response/contingency plan; emergency action plan; confined space entry; and spill containment.

  3. A qualitative assessment of practitioner perspectives post-introduction of the first Continuous Professional Competence (CPC) guidelines for emergency medical technicians in Ireland.

    LENUS (Irish Health Repository)

    Knox, Shane

    2015-01-01

    In November 2013, the Irish Regulator for emergency medical technicians (EMTs) introduced the first mandatory requirement for registrants to demonstrate evidence of continuous professional development (CPD)\\/continuous professional competence (CPC). This qualitative study assessed the experience of practitioners with CPC-related materials provided to them by the Regulator in addition to identifying perceived or encountered practical challenges and suggested improvements six months following introduction of the requirement.

  4. Reliability Based Calibration of Fatigue Design Guidelines for Ship Structures

    DEFF Research Database (Denmark)

    Folsø, Rasmus; Otto, S.; Parmentier, G.

    2002-01-01

    A simple reliability based framework is applied to calibrate a new set of fatigue design guidelines. This new guideline considers two different approaches for the assessment of both loads, stresses and local stress raising effects, and partial safety factors must be given for any combination of t...

  5. Clinical Practice Guidelines for Transfusion of Patients in Critical Condition.

    OpenAIRE

    Rafael Alejandro Gómez Baute; Diosdania Alfonso Falcón; Liermis Dita Salabert; Luciano Núñez Almoguea.

    2009-01-01

    Clinical Practice Guidelines for Transfusion of Patients in Critical Condition. We stress transfusion criteria (blood cells, platelets, granulocyte concentrations, plasma and cryoprecipitate), doses, diagnosis and treatment of post-transfusion reactions. It includes assessment guidelines focused on the most important aspects to be accomplished.

  6. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease.

    OpenAIRE

    Niurka Mercedes Galende Hernández; Diosdania Alfonso Falcón; Carlos Alberto Martell Alonso; Alexis Díaz Mesa; Inti Santana Carballosa

    2009-01-01

    Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most i...

  7. Variation in guideline adherence in intrauterine insemination care.

    NARCIS (Netherlands)

    Haagen, E.C.; Nelen, W.L.D.M.; Grol, R.P.T.M.; Braat, D.D.M.; Hermens, R.P.M.G.; Kremer, J.A.M.

    2010-01-01

    Health-care delivery according to clinical practice guidelines is thought to be critical in achieving optimal outcomes. This study aimed to assess the extent to which practice performance in intrauterine insemination (IUI) care is consistent with guideline recommendations and to evaluate the associa

  8. Exercise in Pregnancy: Guidelines.

    Science.gov (United States)

    Artal, Raul

    2016-09-01

    In recent years it has been recognized that in all phases of life, including pregnancy, physical activity promotes health benefits and precludes comorbidities, the scientific evidence is indisputable. Several organizations around the world have updated in recent years the guidelines and recommendations for exercise in pregnancy. The December 2015, updated guidelines of the American College of Obstetricians and Gynecologists emphasize that physical activity in pregnancy has minimal risk. Although recommending exercise in pregnancy, the anatomic/physiological changes, absolute and relative contraindications should be considered. Women who exercised regularly before pregnancy, in the absence of contraindications, can continue and engage in moderate to strenuous activities, although information on strenuous activities in pregnancy is still limited. This review summarizes the most recent published and recommended guidelines. PMID:27398880

  9. Canadian physical activity guidelines for adults: are Canadians aware?

    Science.gov (United States)

    Dale, Leila Pfaeffli; LeBlanc, Allana G; Orr, Krystn; Berry, Tanya; Deshpande, Sameer; Latimer-Cheung, Amy E; O'Reilly, Norm; Rhodes, Ryan E; Tremblay, Mark S; Faulkner, Guy

    2016-09-01

    The present study evaluated awareness of the Canadian Society for Exercise Physiology's 2011 Canadian Physical Activity Guidelines for Adults and assessed correlates. Reported awareness of the physical activity (PA) guidelines was 12.9% (204/1586) of the total sample surveyed. More than half (55%) self-reported meeting PA guidelines of ≥ 150 min of moderate to vigorous PA per week. Awareness of PA guidelines was significantly related to participants' level of PA (χ(2) (1) = 30.63, p < 0.001, φ = -0.14), but not to any demographic variables. PMID:27560541

  10. Literacy and Language Education: The Quantification of Learning

    Science.gov (United States)

    Gibb, Tara

    2015-01-01

    This chapter describes international policy contexts of adult literacy and language assessment and the shift toward standardization through measurement tools. It considers the implications the quantification of learning outcomes has for pedagogy and practice and for the social inclusion of transnational migrants.

  11. Strategy Guideline: Demonstration Home

    Energy Technology Data Exchange (ETDEWEB)

    Savage, C.; Hunt, A.

    2012-12-01

    This guideline will provide a general overview of the different kinds of demonstration home projects, a basic understanding of the different roles and responsibilities involved in the successful completion of a demonstration home, and an introduction into some of the lessons learned from actual demonstration home projects. Also, this guideline will specifically look at the communication methods employed during demonstration home projects. And lastly, we will focus on how to best create a communication plan for including an energy efficient message in a demonstration home project and carry that message to successful completion.

  12. Strategy Guideline. Demonstration Home

    Energy Technology Data Exchange (ETDEWEB)

    Hunt, A.; Savage, C.

    2012-12-01

    This guideline will provide a general overview of the different kinds of demonstration home projects, a basic understanding of the different roles and responsibilities involved in the successful completion of a demonstration home, and an introduction into some of the lessons learned from actual demonstration home projects. Also, this guideline will specifically look at the communication methods employed during demonstration home projects. And lastly, we will focus on how to best create a communication plan for including an energy efficient message in a demonstration home project and carry that message to successful completion.

  13. OSART guidelines. 1994 edition

    International Nuclear Information System (INIS)

    These guidelines have been prepared to provide a basic structure and common reference both across the various areas covered by an OSART mission and across all the missions in the programme. As such, they are addressed, principally, to the team members of OSART missions but they will also provide guidance to a host nuclear plant preparing to receive a mission. The guidelines are intended to help each expert to formulate his review in the light of this own experience. They are not all inclusive and should not limit the expert's investigations, but are better considered as illustrating the adequate requirements for his review

  14. Measure Guideline. Internal Insulation of Masonry Walls

    Energy Technology Data Exchange (ETDEWEB)

    Straube, J. F. [Building Science Corporation (BSC), Somerville, MA (United States); Ueno, K. [Building Science Corporation (BSC), Somerville, MA (United States); Schumacher, C. J. [Building Science Corporation (BSC), Somerville, MA (United States)

    2012-07-01

    This measure guideline provides recommendations for interior insulation assemblies that control interstitial condensation and durability risks; recommendations for acceptable thermal performance are also provided. An illustrated guide of high-risk exterior details (which concentrate bulk water), and recommended remediation details is provided. This is followed by a recommended methodology for risk assessment of a masonry interior insulation project: a series of steps are suggested to assess the risks associated with this retrofit, with greater certainty with added steps.

  15. Measure Guideline: Internal Insulation of Masonry Walls

    Energy Technology Data Exchange (ETDEWEB)

    Straube, J. F.; Ueno, K.; Schumacher, C. J.

    2012-07-01

    This measure guideline provides recommendations for interior insulation assemblies that control interstitial condensation and durability risks; recommendations for acceptable thermal performance are also provided. An illustrated guide of high-risk exterior details (which concentrate bulk water), and recommended remediation details is provided. This is followed by a recommended methodology for risk assessment of a masonry interior insulation project: a series of steps are suggested to assess the risks associated with this retrofit, with greater certainty with added steps.

  16. Clinical Practice Guidelines for Cerebrovascular Disease Treatment

    Directory of Open Access Journals (Sweden)

    Rubén Bembibre Taboada

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Cerebrovascular Disease Treatment. Even when this term makes reference to the whole process affecting part of cerebral vessel system and cerebral tissue, this document focuses on the cerebrovascular or acute neurological event abruptly affecting the cerebral tissue and the neurological condition of the patient. This condition is usually cause by an abrupt vessel occlusion, of thrombotic or embolic origin, or by subarachnoid or intraventricular intraparenchymatous hemorrhage, of aneurism origin, related with hypertension or with a tumour or arteriovenous defects. The main concepts, classification and conduct are reviewed, stressing the cerebrovascular accident. It includes assessment guidelines focused on the most important aspects to be accomplished.

  17. Quantification is Neither Necessary Nor Sufficient for Measurement

    International Nuclear Information System (INIS)

    Being an infrastructural, widespread activity, measurement is laden with stereotypes. Some of these concern the role of measurement in the relation between quality and quantity. In particular, it is sometimes argued or assumed that quantification is necessary for measurement; it is also sometimes argued or assumed that quantification is sufficient for or synonymous with measurement. To assess the validity of these positions the concepts of measurement and quantitative evaluation should be independently defined and their relationship analyzed. We contend that the defining characteristic of measurement should be the structure of the process, not a feature of its results. Under this perspective, quantitative evaluation is neither sufficient nor necessary for measurement

  18. Carbon dioxide laser guidelines

    Directory of Open Access Journals (Sweden)

    Krupa Shankar D

    2009-01-01

    Full Text Available The carbon dioxide (CO 2 laser is a versatile tool that has applications in ablative lasing and caters to the needs of routine dermatological practice as well as the aesthetic, cosmetic and rejuvenation segments. This article details the basics of the laser physics as applicable to the CO 2 laser and offers guidelines for use in many of the above indications.

  19. Record Keeping Guidelines

    Science.gov (United States)

    American Psychologist, 2007

    2007-01-01

    These guidelines are designed to educate psychologists and provide a framework for making decisions regarding professional record keeping. State and federal laws, as well as the American Psychological Association's "Ethical Principles of Psychologists and Code of Conduct," generally require maintenance of appropriate records of psychological…

  20. MAAP application guidelines

    International Nuclear Information System (INIS)

    The objectives of the Modular Accident Analysis Program (MAAP) Application Guidelines are to: help the user to determine whether MAAP is appropriate for the application(s) considered; identify initiating events and accident scenarios; identify the systems that may respond to postulated events and how they are simulated by MAAP; provide detailed guidance on: how to select model input parameters; sources of input data; how to set up the MAAP calculation; and how to interpret MAAP results; identify the major limitations of MAAP and the qualified range of application; and provide a road map to relevant documents. There will be two separate documents boiling water reactor and pressurized water reactor. Each Application Guideline document references other MAAP reports. Specific sections of the User's Manual will be referenced to in order to facilitate model development and deck setup. It is planned to have a loose leaf structure so information can be kept up to date. Key findings from reports documenting MAAP analyses will be cited in the specific event analysis guidelines. The findings from Electric Power Research Institute's MAAP Thermal-Hydraulic Qualification and Application project are summarized in the applicable sections. It is intended that the Application Guidelines will facilitate the use of other MAAP documents and that repetition will be minimized

  1. Children's Advertising Guidelines.

    Science.gov (United States)

    Council of Better Business Bureaus, Inc., New York, NY.

    These guidelines have been developed for the use of advertisers and advertising agencies and for the self-regulatory mechanism which these groups have established, the National Advertising Division, to help ensure that advertising directed to children is truthful, accurate, and fair to children's perceptions. Preliminary sections set forth basic…

  2. Measure Guideline: Evaporative Condensers

    Energy Technology Data Exchange (ETDEWEB)

    German, A [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Dakin, B. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Hoeschele, M. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States)

    2012-03-01

    This measure guideline on evaporative condensers provides information on properly designing, installing, and maintaining evaporative condenser systems as well as understanding the benefits, costs, and tradeoffs. This is a prescriptive approach that outlines selection criteria, design and installation procedures, and operation and maintenance best practices.

  3. Curriculum Guidelines for Pharmacology.

    Science.gov (United States)

    Shaw, David H.; And Others

    1990-01-01

    Pharmacology embraces the physical and chemical properties of drugs; the preparation of pharmaceutical agents; the absorption, fate, and excretion of drugs; and the effects of drugs on living systems. These guidelines represent a consensus on what would constitute a minimally acceptable pharmacology course for predoctoral dental students. (MLW)

  4. Formalization of Medical Guidelines

    Czech Academy of Sciences Publication Activity Database

    Peleška, Jan; Anger, Z.; Buchtela, David; Šebesta, K.; Tomečková, Marie; Veselý, Arnošt; Zvára, K.; Zvárová, Jana

    2005-01-01

    Roč. 1, - (2005), s. 133-141. ISSN 1801-5603 R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : GLIF model * formalization of guidelines * prevention of cardiovascular diseases Subject RIV: IN - Informatics, Computer Science

  5. Curricular Guidelines for Endodontics.

    Science.gov (United States)

    Journal of Dental Education, 1981

    1981-01-01

    Guidelines developed by the Section on Endodontics of the American Association of Dental Schools for use by educational institutions as curriculum development aids are provided. Endodontics is that branch of dentistry dealing with diagnosis and treatment of oral conditions that arise as a result of pathoses of dental pulp. (MLW)

  6. Instructional Guidelines. Welding.

    Science.gov (United States)

    Fordyce, H. L.; Doshier, Dale

    Using the standards of the American Welding Society and the American Society of Mechanical Engineers, this welding instructional guidelines manual presents a course of study in accordance with the current practices in industry. Intended for use in welding programs now practiced within the Federal Prison System, the phases of the program are…

  7. Field Campaign Guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, J. W. [DOE ARM Climate Research Facility, Washington, DC (United States); Chapman, L. A. [DOE ARM Climate Research Facility, Washington, DC (United States)

    2015-12-01

    This document establishes a common set of guidelines for the Atmospheric Radiation Measurement (ARM) Climate Research Facility for planning, executing, and closing out field campaigns. The steps that guide individual field campaigns are described in the Field Campaign Tracking System and are specifically tailored to meet the scope of each field campaign.

  8. Guidelines for Dual Energy X-Ray Absorptiometry Analysis of Trabecular Bone-Rich Regions in Mice: Improved Precision, Accuracy, and Sensitivity for Assessing Longitudinal Bone Changes.

    Science.gov (United States)

    Shi, Jiayu; Lee, Soonchul; Uyeda, Michael; Tanjaya, Justine; Kim, Jong Kil; Pan, Hsin Chuan; Reese, Patricia; Stodieck, Louis; Lin, Andy; Ting, Kang; Kwak, Jin Hee; Soo, Chia

    2016-05-01

    Trabecular bone is frequently studied in osteoporosis research because changes in trabecular bone are the most common cause of osteoporotic fractures. Dual energy X-ray absorptiometry (DXA) analysis specific to trabecular bone-rich regions is crucial to longitudinal osteoporosis research. The purpose of this study is to define a novel method for accurately analyzing trabecular bone-rich regions in mice via DXA. This method will be utilized to analyze scans obtained from the International Space Station in an upcoming study of microgravity-induced bone loss. Thirty 12-week-old BALB/c mice were studied. The novel method was developed by preanalyzing trabecular bone-rich sites in the distal femur, proximal tibia, and lumbar vertebrae via high-resolution X-ray imaging followed by DXA and micro-computed tomography (micro-CT) analyses. The key DXA steps described by the novel method were (1) proper mouse positioning, (2) region of interest (ROI) sizing, and (3) ROI positioning. The precision of the new method was assessed by reliability tests and a 14-week longitudinal study. The bone mineral content (BMC) data from DXA was then compared to the BMC data from micro-CT to assess accuracy. Bone mineral density (BMD) intra-class correlation coefficients of the new method ranging from 0.743 to 0.945 and Levene's test showing that there was significantly lower variances of data generated by new method both verified its consistency. By new method, a Bland-Altman plot displayed good agreement between DXA BMC and micro-CT BMC for all sites and they were strongly correlated at the distal femur and proximal tibia (r=0.846, p<0.01; r=0.879, p<0.01, respectively). The results suggest that the novel method for site-specific analysis of trabecular bone-rich regions in mice via DXA yields more precise, accurate, and repeatable BMD measurements than the conventional method. PMID:26956416

  9. Inspector qualification guidelines

    International Nuclear Information System (INIS)

    The OECD Nuclear Energy Agency Committee on Nuclear Regulatory Activities (CNRA) has a Working Group on Inspection Practices (WGIP). The WGIP provides a forum for the exchange of Information and experience on the safety Inspection practices of regulatory authorities In the CNRA member countries. A consistent qualification process and well defined level of training for all Inspectors who participate In the safety Inspections are needed to provide consistent Inspections and reliable Inspection results. The WGIP organized in 1992 a workshop on the conduct of inspections, inspector qualification and training, and shutdown inspections at the Technical Training Center of the US NRC in Chattanooga, Tennessee. In the connection of workshop the WGIP identified a need to develop guidance for inspector qualification which could be used as a model by those who are developing their qualification practices. The inspector qualification journals of US NRC provided a good basis for the work. The following inspector qualification guideline has been developed for guidance of qualification of a new inspector recruited to the regulatory body. This guideline has been developed for helping the supervisors and training officers to give the initial training and familiarization to the duties of a new inspector in a controlled manner. US NRC inspector qualification journals have been used to define the areas of attention. This guideline provides large flexibility for application in different type organizations. Large organizations can develop separate qualification journals for each inspector positions. Small regulatory bodies can develop individual training programmes by defining the necessary training topics on case by case basis. E.g. the guideline can be used to define the qualifications of contracted inspectors used in some countries. The appropriate part would apply. Annex 1 gives two examples how this guideline could be applied

  10. Automated lobar quantification of emphysema in patients with severe COPD

    International Nuclear Information System (INIS)

    Automated lobar quantification of emphysema has not yet been evaluated. Unenhanced 64-slice MDCT was performed in 47 patients evaluated before bronchoscopic lung-volume reduction. CT images reconstructed with a standard (B20) and high-frequency (B50) kernel were analyzed using a dedicated prototype software (MevisPULMO) allowing lobar quantification of emphysema extent. Lobar quantification was obtained following (a) a fully automatic delineation of the lobar limits by the software and (b) a semiautomatic delineation with manual correction of the lobar limits when necessary and was compared with the visual scoring of emphysema severity per lobe. No statistically significant difference existed between automated and semiautomated lobar quantification (p>0.05 in the five lobes), with differences ranging from 0.4 to 3.9%. The agreement between the two methods (intraclass correlation coefficient, ICC) was excellent for left upper lobe (ICC=0.94), left lower lobe (ICC=0.98), and right lower lobe (ICC=0.80). The agreement was good for right upper lobe (ICC=0.68) and moderate for middle lobe (IC=0.53). The Bland and Altman plots confirmed these results. A good agreement was observed between the software and visually assessed lobar predominance of emphysema (kappa 0.78; 95% CI 0.64-0.92). Automated and semiautomated lobar quantifications of emphysema are concordant and show good agreement with visual scoring. (orig.)

  11. GMO quantification: valuable experience and insights for the future.

    Science.gov (United States)

    Milavec, Mojca; Dobnik, David; Yang, Litao; Zhang, Dabing; Gruden, Kristina; Zel, Jana

    2014-10-01

    Cultivation and marketing of genetically modified organisms (GMOs) have been unevenly adopted worldwide. To facilitate international trade and to provide information to consumers, labelling requirements have been set up in many countries. Quantitative real-time polymerase chain reaction (qPCR) is currently the method of choice for detection, identification and quantification of GMOs. This has been critically assessed and the requirements for the method performance have been set. Nevertheless, there are challenges that should still be highlighted, such as measuring the quantity and quality of DNA, and determining the qPCR efficiency, possible sequence mismatches, characteristics of taxon-specific genes and appropriate units of measurement, as these remain potential sources of measurement uncertainty. To overcome these problems and to cope with the continuous increase in the number and variety of GMOs, new approaches are needed. Statistical strategies of quantification have already been proposed and expanded with the development of digital PCR. The first attempts have been made to use new generation sequencing also for quantitative purposes, although accurate quantification of the contents of GMOs using this technology is still a challenge for the future, and especially for mixed samples. New approaches are needed also for the quantification of stacks, and for potential quantification of organisms produced by new plant breeding techniques. PMID:25182968

  12. Assessment of knowledge, attitude and practice of prescription writing as per Medical Council of India guidelines among interns in a Medical College

    Directory of Open Access Journals (Sweden)

    Sumalatha R

    2016-02-01

    Full Text Available Objective: To assess the knowledge, attitude and practice of prescription writing among interns in medical college.Materials and Methods: A cross-sectional study was conducted among the interns in a Medical College, after taking approval from the Institutional Ethics Committee. Participants were asked to write prescription for a common ailment in a given prescription blank page. A structured questionnaire was designed based on new Medical Council of India (MCI prescription writing pattern to analyse the prescription. The data was analysed using descriptive statistics.Results: Among 84 interns, most of the participants had written the drug by generic name (95.2% and have signed in the prescription sheet (98%. None of them were aware of the latest prescription writing pattern recommended by Medical Council of India (MCI. The writing of generic name in capital letter was not done by 97.6% of interns.    Conclusion: Our study concluded that interns were not aware of new Medical Council of India (MCI prescription writing pattern. Majority of interns have made errors while writing the prescription. Thus there is a need for regular formal education regarding prescription writing, before the start of internship. They can be given training under medical education unit regarding the recent updates of prescription writing.

  13. Guidelines for the verification and validation of expert system software and conventional software: Survey and assessment of conventional software verification and validation methods. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Mirsky, S.M.; Groundwater, E.H.; Hayes, J.E.; Miller, L.A. [Science Applications International Corp., McLean, VA (United States)

    1995-03-01

    By means of a literature survey, a comprehensive set of methods was identified for the verification and validation of conventional software. The 153 methods so identified were classified according to their appropriateness for various phases of a developmental life-cycle -- requirements, design, and implementation; the last category was subdivided into two, static testing and dynamic testing methods. The methods were then characterized in terms of eight rating factors, four concerning ease-of-use of the methods and four concerning the methods` power to detect defects. Based on these factors, two measurements were developed to permit quantitative comparisons among methods, a Cost-Benefit metric and an Effectiveness Metric. The Effectiveness Metric was further refined to provide three different estimates for each method, depending on three classes of needed stringency of V&V (determined by ratings of a system`s complexity and required-integrity). Methods were then rank-ordered for each of the three classes by terms of their overall cost-benefits and effectiveness. The applicability was then assessed of each for the identified components of knowledge-based and expert systems, as well as the system as a whole.

  14. Guidelines for the verification and validation of expert system software and conventional software: Survey and assessment of conventional software verification and validation methods. Volume 2

    International Nuclear Information System (INIS)

    By means of a literature survey, a comprehensive set of methods was identified for the verification and validation of conventional software. The 153 methods so identified were classified according to their appropriateness for various phases of a developmental life-cycle -- requirements, design, and implementation; the last category was subdivided into two, static testing and dynamic testing methods. The methods were then characterized in terms of eight rating factors, four concerning ease-of-use of the methods and four concerning the methods' power to detect defects. Based on these factors, two measurements were developed to permit quantitative comparisons among methods, a Cost-Benefit metric and an Effectiveness Metric. The Effectiveness Metric was further refined to provide three different estimates for each method, depending on three classes of needed stringency of V ampersand V (determined by ratings of a system's complexity and required-integrity). Methods were then rank-ordered for each of the three classes by terms of their overall cost-benefits and effectiveness. The applicability was then assessed of each for the identified components of knowledge-based and expert systems, as well as the system as a whole

  15. Guidelines for the responsible management of plutonium

    International Nuclear Information System (INIS)

    Since 1994 an informal group of representatives of States party to the NPT has been trying to develop agreed international guidelines for the responsible management of non-military plutonium. This paper gives a brief description of the outcome. Since the results are still subject to decision by Governments, the description must be in general terms only. The paper describes the background to, and genesis of, the discussions and the general approach taken, which was based on commitment to the NPT, national responsibility for the management of nuclear materials and the fuel cycle, upholding of the IAEA's safeguards system, and a focus on civil material. An indication is given of the development of the Group's thinking, especially the decisions that any guidelines must be capable of accommodating surplus military plutonium, as well as civil, and that the main focus should be on measures to increase transparency. The resulting guidelines are described. Their main features are a re-statement of commitments and standards for the management of non-military plutonium with regard to non-proliferation, safety, and other fields, a commitment to the management of such plutonium according to a consistent national strategy, and a commitment to the publication of information on that strategy, and of annual statistics for holdings of plutonium in a consistent format. Other aspects of the guidelines are also explained. Finally, an attempt is made to assess the possible practical effects of the guidelines if adopted by governments. (author)

  16. Gas chromatographic validated method for quantification of ayurvedic polyherbal formulation

    Directory of Open Access Journals (Sweden)

    Navdeep Saini

    2015-01-01

    Full Text Available A new gas chromatographic-flame ionization detector (GC-FID method was developed for quantification of ayurvedic polyherbal formulation. The GC-FID method was found highly accurate, sensitive, simple and precise. This method was validated as per international conference on harmonization (ICH guidelines. Experimental work was performed by nonpolar capillary column (Zb-5, 5%-Phenyl-95%-dimethylpolysiloxane. Film thickness of capillary column (Zb-5 was (0.25 μm and length 30 m × 0.25 mm i.d. The temperature of the oven, injector and detector were 200, 210 and 280°C respectively. Data processing system was applied to obtain data. The standards and test samples were prepared in absolute ethanol. The principle constituents t-Anethol, d-Limonene, cuminaldehyde and thymol were found in ayurvedic polyherbal formulation. The ICH validation parameters for the proposed procedure, recovery (limit 98.85-100.76%, precision (<1.00%, limits of detection, limits of quantification and linearity (r2 = 0.995 ± 0.002 were observed under acceptance limit. Validation results were statistically calculated. The result shows that method is selective and reproducible for quantification of ayurvedic polyherbal formulation. The presented GC method can be applied for the routine analysis of principle constituents as well as ayurvedic polyherbal formulation.

  17. The quantification of hazards

    International Nuclear Information System (INIS)

    The seventh chapter deals in detail with the means and methods allowing to quantify the objective dimension and scope of a hazard in concrete situations. Source and type of possible damage and exposure path determine the detection and perception of hazards. Risk assessment requires the determination of the dose-effect relationship of the hazard situation and of the dimension and the probability of the damage. Risk assessments are exemplified: influenza epidemic; accidents in a nuclear power plant; the risk for the population emanating from normal nuclear power plant operation. The author concludes that subjective elements inevitably enter into any risk assessment - though to a varying extent - and, hence, that objectivity is but relative. (HSCH)

  18. MedlinePlus: Quality Guidelines

    Science.gov (United States)

    ... this page: https://medlineplus.gov/criteria.html MedlinePlus Quality Guidelines To use the sharing features on this ... materials must also meet our existing quality guidelines. Quality, authority and accuracy of health content The organization's ...

  19. Guidelines for Home Energy Professionals

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-12-16

    The U.S. Department of Energy's (DOE's) Guidelines for Home Energy Professionals project (hereafter the Guidelines) fosters the growth of a high quality residential energy upgrade industry and a skilled and credentialed workforce.

  20. Evaluation of clinical practice guidelines.

    OpenAIRE

    Basinski, A S

    1995-01-01

    Compared with the current focus on the development of clinical practice guidelines the effort devoted to their evaluation is meagre. Yet the ultimate success of guidelines depends on routine evaluation. Three types of evaluation are identified: evaluation of guidelines under development and before dissemination and implementation, evaluation of health care programs in which guidelines play a central role, and scientific evaluation, through studies that provide the scientific knowledge base fo...

  1. MAMA Software Features: Quantification Verification Documentation-1

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, Christy E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Porter, Reid B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-05-21

    This document reviews the verification of the basic shape quantification attributes in the MAMA software against hand calculations in order to show that the calculations are implemented mathematically correctly and give the expected quantification results.

  2. Guidelines or gospels?

    Science.gov (United States)

    Sundt, Thoralf M

    2016-06-01

    In the interest of advancing evidenced-based medicine, enthusiasm for clinical practice guidelines has skyrocketed. They have a genuine impact on clinical practice and are frequently referenced in the literature. Their construction is complex and labor intensive, and has significant limitations given the necessary process as well as the data available. There has been less focus on their appropriate clinical application as dictated by these inherent limitations. It is worthwhile taking a step back and considering how we know what we think we know based on statistical analysis of biomedical data sets and the real implications of those population data for making predictions about the individual patient we encounter in the clinic. These data as used to establish guidelines for care should be the foundation and starting point for our thoughtful recommendations and decision making, not the final word. The importance of nuance in clinical judgment remains even in this "evidence-based" world. PMID:26992602

  3. Offshore waste treatment guidelines

    International Nuclear Information System (INIS)

    These guidelines were prepared to aid offshore oil and gas operators in the management of waste materials related to petroleum drilling and production operations in offshore areas regulated by the Canada-Newfoundland and Labrador Offshore Petroleum Board (CNLOPB) and the Canada-Nova Scotia Offshore Petroleum Board (CNSOPB). A description of the relevant sections of the regulatory regime applicable to Canada's offshore oil and gas operations was included. Offshore operators are expected to take all reasonable measures to minimize the volumes of waste materials generated by their operations. The guidelines included recommendations for identifying, monitoring, and reporting discharges; performance expectations for specific discharges; requirements for greenhouse gas (GHG) and other air emissions; methods of characterizing and monitoring produced water, drilling muds, and desalination brine. Operational discharges associated with the installation and maintenance of subsea systems were also reviewed, and qualifications of analytical laboratories were presented. 24 refs., 2 appendices.

  4. Adherence to dietary guidelines and cardiovascular disease risk in the EPIC-NL cohort

    NARCIS (Netherlands)

    Struijk, E.A.; May, A.M.; Wezenbeek, N.L.W.J.; Fransen, H.; Soedamah-Muthu, S.S.; Geelen, A.; Boer, J.; Schouw, van der Y.T.; Bueno de Mesquita, H.B.; Beulens, J.W.J.

    2014-01-01

    Background Global and national dietary guidelines have been created to lower chronic disease risk. The aim of this study was to assess whether greater adherence to the WHO guidelines (Healthy Diet Indicator (HDI)); the Dutch guidelines for a healthy diet (Dutch Healthy Diet-index (DHD-index)); and t

  5. Guidelines for Design, Development and Delivery of Programmes/Courses through Distance Mode.

    Science.gov (United States)

    Prasad, V. S.; Rausaria, R. R.; Lele, Nalini A.; Bhushan, Bharat

    These guidelines were developed by the Distance Education Council (India) to provide institutions with action guidelines for development and delivery of distance education programs; to provide a framework for the maintenance of standards and quality assurance; and to provide benchmarks for self assessment. The guidelines highlight three essential…

  6. Pressure Ulcers in Adults: Prediction and Prevention. Clinical Practice Guideline Number 3.

    Science.gov (United States)

    Agency for Health Care Policy and Research (DHHS/PHS), Rockville, MD.

    This package includes a clinical practice guideline, quick reference guide for clinicians, and patient's guide to predicting and preventing pressure ulcers in adults. The clinical practice guideline includes the following: overview of the incidence and prevalence of pressure ulcers; clinical practice guideline (introduction, risk assessment tools…

  7. TORIS Data Preparation Guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Guinn, H.; Remson, D.

    1999-03-11

    The objective of this manual is to present guidelines and procedures for the preparation of new data for the Tertiary Oil Recovery Information System (TORIS) data base. TORIS is an analytical system currently maintained by the Department of Energy's (DOE) Bartlesville Project Office. It uses an extensive field- and reservoir-level data base to evaluate the technical and economic recovery potential of specific crude oil reservoirs.

  8. Measure Guideline: Evaporative Condensers

    Energy Technology Data Exchange (ETDEWEB)

    German, A.; Dakin, B.; Hoeschele, M.

    2012-03-01

    The purpose of this measure guideline on evaporative condensers is to provide information on a cost-effective solution for energy and demand savings in homes with cooling loads. This is a prescriptive approach that outlines selection criteria, design and installation procedures, and operation and maintenance best practices. This document has been prepared to provide a process for properly designing, installing, and maintaining evaporative condenser systems as well as understanding the benefits, costs, and tradeoffs.

  9. Guidelines for emergency laparoscopy

    Directory of Open Access Journals (Sweden)

    Sauerland Stefan

    2006-10-01

    Full Text Available Abstract Acute abdominal pain is a leading symptom in many surgical emergency patients. Laparoscopy allows for accurate diagnosis and immediate therapy of many intraabdominal pathologies. The guidelines of the EAES (European Association for Endoscopic Surgery provides scientifically founded recommendations about the role of laparoscopy in the different situations. Generally, laparoscopy is well suited for the therapy of the majority of diseases that cause acute abdominal pain.

  10. CIMP Internet Addiction Guideline

    OpenAIRE

    Azizah Zainudin; Marina Md Din; Marini Othman

    2013-01-01

    Nowadays, Internet addiction has become a major problem to the university students. The purpose of this study is to present a guideline to helps people to overcome their Internet addiction especially for students. There were 653 university students (341 females and 312 males) from five different universities in Malaysia have completed related survey. The survey questionnaires were taken from Young?s Addiction Scale (1996) and some questions were created by the researcher. In this paper, there...

  11. Tinnitus guidelines and treatment

    DEFF Research Database (Denmark)

    Larsen, Dalia Gustaityté; Ovesen, Therese

    2014-01-01

    In this study literature search was performed on tinnitus guidelines and treatment. Tinnitus can be described as the perception of sound in the absence of external acoustic stimulation, and validated questionnaires, oto-neurological examination, audiometry tests, MRI and angiography are necessary...... as diagnostic tools. Antidepressants, melatonin and cognitive behavioural therapy have no effect on tinnitus, whereas sound generators, hearing aids and tinnitus retraining therapy show some but limited improvement. National recommendations are required to ensure a homogenous and optimum offer for...

  12. FIS accreditation guidelines

    OpenAIRE

    Ojanen, Pinja

    2010-01-01

    The International Ski Federation (FIS) was founded to support and develop the sport of skiing 100 years ago. Since then skiing has grown in importance and has become more popular. Nowadays ski companies, athletes and family members, but also fan clubs, national ski associations, sponsors and local organizers get involved for a sporting event. The aim of this project-based thesis was to create guidelines and make the FIS accreditation system as user-friendly as possible. For the groups (ser...

  13. Improving the use of research evidence in guideline development: 1. Guidelines for guidelines

    Directory of Open Access Journals (Sweden)

    Oxman Andrew D

    2006-11-01

    Full Text Available Abstract Background The World Health Organization (WHO, like many other organisations around the world, has recognised the need to use more rigorous processes to ensure that health care recommendations are informed by the best available research evidence. This is the first of a series of 16 reviews that have been prepared as background for advice from the WHO Advisory Committee on Health Research to WHO on how to achieve this. Objectives We reviewed the literature on guidelines for the development of guidelines. Methods We searched PubMed and three databases of methodological studies for existing systematic reviews and relevant methodological research. We did not conduct systematic reviews ourselves. Our conclusions are based on the available evidence, consideration of what WHO and other organisations are doing and logical arguments. Key questions and answers We found no experimental research that compared different formats of guidelines for guidelines or studies that compared different components of guidelines for guidelines. However, there are many examples, surveys and other observational studies that compared the impact of different guideline development documents on guideline quality. What have other organizations done to develop guidelines for guidelines from which WHO can learn? • Establish a credible, independent committee that evaluates existing methods for developing guidelines or that updates existing ones. • Obtain feedback and approval from various stakeholders during the development process of guidelines for guidelines. • Develop a detailed source document (manual that guideline developers can use as reference material. What should be the key components of WHO guidelines for guidelines? • Guidelines for guidelines should include information and instructions about the following components: 1 Priority setting; 2 Group composition and consultations; 3 Declaration and avoidance of conflicts of interest; 4 Group processes; 5

  14. Simple quantification of in planta fungal biomass.

    Science.gov (United States)

    Ayliffe, Michael; Periyannan, Sambasivam K; Feechan, Angela; Dry, Ian; Schumann, Ulrike; Lagudah, Evans; Pryor, Anthony

    2014-01-01

    An accurate assessment of the disease resistance status of plants to fungal pathogens is an essential requirement for the development of resistant crop plants. Many disease resistance phenotypes are partial rather than obvious immunity and are frequently scored using subjective qualitative estimates of pathogen development or plant disease symptoms. Here we report a method for the accurate comparison of total fungal biomass in plant tissues. This method, called the WAC assay, is based upon the specific binding of the plant lectin wheat germ agglutinin to fungal chitin. The assay is simple, high-throughput, and sensitive enough to discriminate between single Puccinia graminis f.sp tritici infection sites on a wheat leaf segment. It greatly lends itself to replication as large volumes of tissue can be pooled from independent experiments and assayed to provide truly representative quantification, or, alternatively, fungal growth on a single, small leaf segment can be quantified. In addition, as the assay is based upon a microscopic technique, pathogen infection sites can also be examined at high magnification prior to quantification if desired and average infection site areas are determined. Previously, we have demonstrated the application of the WAC assay for quantifying the growth of several different pathogen species in both glasshouse grown material and large-scale field plots. Details of this method are provided within. PMID:24643560

  15. Quantification of ecological debt

    International Nuclear Information System (INIS)

    The discussion about ecological debt is important keeping in mind historical foreign trade, where natural resources exploitation and primary production exported didn't assessment the ecological damage or the environmental values of the interchange. This essay shows the debate of ecological debt on greenhouse emission, enterprise environmental debit, unequal international trade, toxic waste export, and bio piracy; in order to present the necessity of a new ecological and equitable world economy

  16. 寿命期内家用空调的环境影响评价及量化方法%Life Circle Environmental Assessment on Household Air Conditioning and Its Quantification Method

    Institute of Scientific and Technical Information of China (English)

    邵晓炜; 蔡亮; 张小松

    2012-01-01

    根据生命周期评价理论,介绍了各环境影响指标的量化方法.并以家用空调为例,分析其对人类健康、生态品质和资源消耗三大类环境方面的影响,同时得到家用空调在其寿命期内CO2等温室气体以及CS2等有害气体的排放量.结果表明:一台1.5P的家用空调在其寿命期内的环境影响评价指标总值为690Pt,系统在生态品质方面的影响指标最大,为502.65Pt,在人类健康方面的影响指标次之,为98.35Pt,对资源消耗的影响指标为89.46Pt.运行阶段由于电力的使用,对环境的影响指标最大,为681Pt,因此,要降低家用空调在寿命期内对环境的冲击和危害,应重点放在节约电力以及开发新能源的使用上.最后,分析结果得出:一台电力驱动的1.5P普通家用空调在其寿命期内的CO2排放量为1.89×104kg,同时排放SO气体78.017kg,以及其他少数有害气体.评价结果向空调产业部门提供了改善空调器的环境特性所需的必要信息,同时向消费者提供了进行环境决策而需要的有价值的信息资料,促使他们在考虑技术特性和费用的同时也考虑环境影响.%According to life circle assessment theory, the environmental effect indicators and corresponding quantification method were introduced in this paper. Then a household air conditioning was taken as an example, and its environmental effect on human health, ecosystem quality and resource consumption were analyzed. Meanwhile, emission of greenhouse gases and polluted gas were carried out. The results show that its total environment indicator score is 690 Pt. Score on ecosystem quality (502,65Pt) is the highest, and score on resource consumption (89.46Pt) is the lowest. Because of electrical power consumed, the operation phase has the most influence indicator score on environment, which reaches to 681 Pt. To reduce the environmental impact, more attention should be paid on power saving and new energy utilization. Finally

  17. 12 CFR Appendix B to Part 30 - Interagency Guidelines Establishing Information Security Standards

    Science.gov (United States)

    2010-01-01

    ... security program. The frequency and nature of such tests should be determined by the bank's risk assessment... customer. B. Risk Assessment and Controls 1. The Security Guidelines direct every financial institution to... See Security Guidelines, III.B. 2. Following the assessment of these risks, the Security...

  18. Validation and reliability of a guideline appraisal mini-checklist for daily practice use

    OpenAIRE

    Siebenhofer, Andrea; Semlitsch, Thomas; Herborn, Thomas; Siering, Ulrich; Kopp, Ina; Hartig, Johannes

    2016-01-01

    Background The use of comprehensive instruments for guideline appraisal is time-consuming and requires highly qualified personnel. Since practicing physicians are generally busy, the rapid-assessment Mini-Checklist (MiChe) tool was developed to help them evaluate the quality and utility of guidelines quickly. The aim of this study was to validate the MiChe in comparison to the AGREE II instrument and to determine its reliability as a tool for guideline appraisal. Methods Ten guidelines that a...

  19. A review of clinical guidelines.

    LENUS (Irish Health Repository)

    Andrews, E J

    2012-02-03

    BACKGROUND: Clinical guidelines are increasingly used in patient management but few clinicians are familiar with their origin or appropriate application. METHODS: A Medline search using the terms \\'clinical guidelines\\' and \\'practice guidelines\\' was conducted. Additional references were sourced by manual searching from the bibliographies of articles located. RESULTS AND CONCLUSION: Clinical guidelines originated in the USA in the early 1980s, initially as a cost containment exercise. Significant improvements in the process and outcomes of care have been demonstrated following their introduction, although the extent of improvement varies considerably. The principles for the development of guidelines are well established but many published guidelines fall short of these basic quality criteria. Guidelines are only one aspect of improving quality and should be used within a wider framework of promoting clinical effectiveness. Understanding their limitations as well as their potential benefits should enable clinicians to have a clearer view of their place in everyday practice.

  20. Recommendations for kidney disease guideline updating: a report by the KDIGO Methods Committee.

    Science.gov (United States)

    Uhlig, Katrin; Berns, Jeffrey S; Carville, Serena; Chan, Wiley; Cheung, Michael; Guyatt, Gordon H; Hart, Allyson; Lewis, Sandra Zelman; Tonelli, Marcello; Webster, Angela C; Wilt, Timothy J; Kasiske, Bertram L

    2016-04-01

    Updating rather than de novo guideline development now accounts for the majority of guideline activities for many guideline development organizations, including Kidney Disease: Improving Global Outcomes (KDIGO), an international kidney disease guideline development entity that has produced guidelines on kidney diseases since 2008. Increasingly, guideline developers are moving away from updating at fixed intervals in favor of more flexible approaches that use periodic expert assessment of guideline currency (with or without an updated systematic review) to determine the need for updating. Determining the need for guideline updating in an efficient, transparent, and timely manner is challenging, and updating of systematic reviews and guidelines is labor intensive. Ideally, guidelines should be updated dynamically when new evidence indicates a need for a substantive change in the guideline based on a priori criteria. This dynamic updating (sometimes referred to as a living guideline model) can be facilitated with the use of integrated electronic platforms that allow updating of specific recommendations. This report summarizes consensus-based recommendations from a panel of guideline methodology professionals on how to keep KDIGO guidelines up to date. PMID:26994574

  1. Guidelines for the undergraduate psychology major: Version 2.0.

    Science.gov (United States)

    2016-01-01

    The APA Guidelines for the Undergraduate Psychology Major: Version 2.0 (henceforth Guidelines 2.0; APA, 2013) represents a national effort to describe and develop high-quality undergraduate programs in psychology. The task force charged with the revision of the original guidelines for the undergraduate major examined the success of the document's implementation and made changes to reflect emerging best practices and to integrate psychology's work with benchmarking scholarship in higher education. Guidelines 2.0 abandoned the original distinction drawn between psychology-focused skills and psychology skills that enhance liberal arts development. Instead, Guidelines 2.0 describes five inclusive goals for the undergraduate psychology major and two developmental levels of student learning outcomes. Suggestions for assessment planning are provided for each of the five learning goals. PMID:26866986

  2. Guidelines for psychological practice with transgender and gender nonconforming people.

    Science.gov (United States)

    2015-12-01

    In 2015, the American Psychological Association adopted Guidelines for Psychological Practice with Transgender and Gender Nonconforming Clients in order to describe affirmative psychological practice with transgender and gender nonconforming (TGNC) clients. There are 16 guidelines in this document that guide TGNC-affirmative psychological practice across the lifespan, from TGNC children to older adults. The Guidelines are organized into five clusters: (a) foundational knowledge and awareness; (b) stigma, discrimination, and barriers to care; (c) lifespan development; (d) assessment, therapy, and intervention; and (e) research, education, and training. In addition, the guidelines provide attention to TGNC people across a range of gender and racial/ethnic identities. The psychological practice guidelines also attend to issues of research and how psychologists may address the many social inequities TGNC people experience. PMID:26653312

  3. Clinical Practice Guidelines for Bacterial Meningoencephalitis.

    OpenAIRE

    Belkys Rodríguez Llerena.; Luciano Núñez Almoguea.

    2009-01-01

    Clinical Practice Guidelines for Bacterial Meningoencephalitis. It has been defined as an acute inflammatory process caused by bacteria, often purulent, which involves the meninges, subarachnoid space around the brain, spinal cord and usually includes the ventricles. It is caused in the 80% of the patients by three bacteria: Haemophilus influenzae, Neisseria meningitides and Streptococcus pneumonia. Concepts, classification, diagnosis and treatment were reviewed. It includes assessment guidel...

  4. Matching Medical Websites to Medical Guidelines

    OpenAIRE

    Dusan Rak; Vojtech Svatek

    2016-01-01

    The quality of medical texts provided to general public on the Internet is a serious issue nowadays. Unfortunately the only feasible way to approve the adequacy of the medical information content is human verification today. Best practices in medicine are systematically captured by medical guidelines (MGLs), which are provided by renowned medical societies. We propose a simple approach to exploiting MGL content as ’gold standard’ for the assessment of content quality in medical we...

  5. Climate friendly dietary guidelines

    OpenAIRE

    Trolle, Ellen; Mogensen, Lisbeth; Thorsen, Anne Vibeke; Jørgensen, Michael Søgaard

    2014-01-01

    The aim of this study was to investigate how the present Danish diet could be changed in a climate friendly direction that follows the recommendations of a healthy diet.The carbon footprint (CF) of an average Danish diet was calculated and compared to CF of a recommended healthy diet by 1) modifying the average diet according to the Danish food based dietary guidelines, 2) and adjusting to ensure an iso-energy content and a nutrient content according to the Nordic Nutrient Recommendations. Af...

  6. Guidelines for assessment and management of nonalcoholic fatty liver disease in China and Italy:differences and similarities.%中国和意大利非酒精性脂肪性肝病诊疗指南的异同解读

    Institute of Scientific and Technical Information of China (English)

    李瑜元

    2011-01-01

    非酒精性脂肪性肝病(NAFLD)是常见病,2010年中国和意大利先后更新诊疗指南,对照解读有助于对本病的全面理解.两指南观点并无原则上差异,流行病学内容基本一致,两指南一致强调病理学是诊断NAFLD分期的金标准,意大利指南偏重临床诊断流程和对诊断方法的评价;而中国指南致力于制定临床、病理学、影像学等诊断标准.目前尚无NAFLD的特效治疗方法,两指南均主张使用改善胰岛素抵抗的措施和药物,中国指南推荐较多保肝抗炎药物.%Nonalcoholic fatty liver disease(NAFLD) is a common, disorder. An overall understanding of this disease may be improved by comparative interpretation of guidelines for assessment and management of NAFLD updated 2010 in China and in Italy. The two guidelines do not differ in principle,with general agreement on epidemiology and consistent highlight on histopathology as the gold standard for diagnosis and identification of NAFLD. However,the Italian guidelines emphasize more on algorithm for clinical diagnosis and comments for different diagnostic modalities,while the Chinese guidelines focus on development of a diagnostic criteria which include clinical presentations, pathology and imaging. At present, there remains no specific treatment for NAFLD. While both guidelines recommend measures and drugs to improve insulin resistance, the use of hepatoprotective or anti- inflammatory agents is more involved in Chinese guidelines.

  7. IDEAS/IAEA intercomparison exercise on internal dose assessment. Intercomparison exercise on Internal Dose Assessment performed jointly by the International Atomic Energy Agency and the IDEAS project (''General Guidelines for the Evaluation of Incorporation Monitoring Data'', carried out within the 5th EU Framework Programme)

    International Nuclear Information System (INIS)

    There were several intercomparison exercises organized already at national and international levels for the assessment of occupational exposure due to intakes of radionuclides. These intercomparison exercises revealed significant differences in the approaches, methods and assumptions, and consequently in the results. In the frame of the IDEAS project .General Guidelines for the Evaluation of Incorporation Monitoring Data., launched in the 5th EU Framework Programme, a new intercomparison exercise was performed. Originally it was planned to organise this intercomparison exercise on a European scale. Because of the relevance of the issue for the whole community of internal dosimetrists, however, it was decided to organise the exercise on a broader scale together with the IAEA. This new intercomparison exercise especially focuses on the effect of the guidelines for harmonisation of internal dosimetry. In addition it also consider the following aspects: - to provide possibilities for the participating laboratories to check the quality of their internal dose assessment methods in applying the recent ICRP recommendations (new respiratory tract model etc.); - to compare different approaches in interpretation of internal contamination monitoring data; - to quantify the differences in internal dose assessment based on the new guidelines or on other procedures, respectively; - to provide some figures of the influence of the input parameters on the monitoring results and - to provide a broad forum for information exchange. Several cases have been selected for the exercise with the aim to cover a wide range of practices in the nuclear fuel cycle and medical applications. The case were: 1. Acute intake of HTO; 2. Acute inhalation of fission products 137Cs and 90Sr; 3. Intake of 60Co; 4. Repeated intakes of 131I; 5. Intake of enriched uranium; 6. Single intake of Pu radionuclides and 241Am. A web-based approach was being used for the presentation of the cases, collection of

  8. Uncertainty quantification in DIC with Kriging regression

    Science.gov (United States)

    Wang, Dezhi; DiazDelaO, F. A.; Wang, Weizhuo; Lin, Xiaoshan; Patterson, Eann A.; Mottershead, John E.

    2016-03-01

    A Kriging regression model is developed as a post-processing technique for the treatment of measurement uncertainty in classical subset-based Digital Image Correlation (DIC). Regression is achieved by regularising the sample-point correlation matrix using a local, subset-based, assessment of the measurement error with assumed statistical normality and based on the Sum of Squared Differences (SSD) criterion. This leads to a Kriging-regression model in the form of a Gaussian process representing uncertainty on the Kriging estimate of the measured displacement field. The method is demonstrated using numerical and experimental examples. Kriging estimates of displacement fields are shown to be in excellent agreement with 'true' values for the numerical cases and in the experimental example uncertainty quantification is carried out using the Gaussian random process that forms part of the Kriging model. The root mean square error (RMSE) on the estimated displacements is produced and standard deviations on local strain estimates are determined.

  9. Quantification practices in the nuclear industry

    International Nuclear Information System (INIS)

    In this chapter the quantification of risk practices adopted by the nuclear industries in Germany, Britain and France are examined as representative of the practices adopted throughout Europe. From this examination a number of conclusions are drawn about the common features of the practices adopted. In making this survey, the views expressed in the report of the Task Force on Safety Goals/Objectives appointed by the Commission of the European Communities, are taken into account. For each country considered, the legal requirements for presentation of quantified risk assessment as part of the licensing procedure are examined, and the way in which the requirements have been developed for practical application are then examined. (author)

  10. Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries

    DEFF Research Database (Denmark)

    Blomberg, Björn Alexander; Thomassen, Anders; de Jong, Pim A; Simonsen, Jane; Lam, Marnix; Nielsen, Anne; Mickley, Hans; Mali, Willem; Alavi, Abass; Høilund-Carlsen, Poul Flemming

    2015-01-01

    Sodium (18)F-fluoride ((18)F-NaF) PET/CT imaging is a promising imaging technique for assessment of atherosclerosis, but is hampered by a lack of validated quantification protocols. Both personal characteristics and technical factors can affect quantification of arterial (18)F-NaF uptake. This...

  11. Guideline(s) For Planning A Gaming Event - Case Warhammer

    OpenAIRE

    Chan, Siu Yung

    2016-01-01

    The purpose of this thesis was to create a series of general guidelines for organizing a Warhammer 40,000 gaming event for Warhammer store in Helsinki owned by Games Workshop. The guidelines would help the store prepare a gaming event that attracts more participants and in the long term increases sales and customers. Event participants would have fun and enhance their friendship during the game. The guidelines would also be useful for new staff of Warhammer store in future. The theoretica...

  12. Guideline on anterior cruciate ligament injury.

    Science.gov (United States)

    Meuffels, Duncan E; Poldervaart, Michelle T; Diercks, Ron L; Fievez, Alex W F M; Patt, Thomas W; Hart, Cor P van der; Hammacher, Eric R; Meer, Fred van der; Goedhart, Edwin A; Lenssen, Anton F; Muller-Ploeger, Sabrina B; Pols, Margreet A; Saris, Daniel B F

    2012-08-01

    The Dutch Orthopaedic Association has a long tradition of development of practical clinical guidelines. Here we present the recommendations from the multidisciplinary clinical guideline working group for anterior cruciate ligament injury. The following 8 clinical questions were formulated by a steering group of the Dutch Orthopaedic Association. What is the role of physical examination and additional diagnostic tools? Which patient-related outcome measures should be used? What are the relevant parameters that influence the indication for an ACL reconstruction? Which findings or complaints are predictive of a bad result of an ACL injury treatment? What is the optimal timing for surgery for an ACL injury? What is the outcome of different conservative treatment modalities? Which kind of graft gives the best result in an ACL reconstruction? What is the optimal postoperative treatment concerning rehabilitation, resumption of sports, and physiotherapy? These 8 questions were answered and recommendations were made, using the "Appraisal of Guidelines for Research and Evaluation" instrument. This instrument seeks to improve the quality and effectiveness of clinical practical guidelines by establishing a shared framework to develop, report, and assess. The steering group has also developed 7 internal indicators to aid in measuring and enhancing the quality of the treatment of patients with an ACL injury, for use in a hospital or practice. PMID:22900914

  13. Postdoctoral program guidelines.

    Energy Technology Data Exchange (ETDEWEB)

    Teich-McGoldrick, Stephanie; Miller, Andrew W.; Sava, Dorina Florentina; Liu, Yanli; Ferreira, Summer Rhodes; Biedermann, Laura Butler; Cruz-Campa, Jose Luis; Hall, Lisa Michelle; Liu, Xiaohua H.; Ekoto, Isaac

    2012-04-01

    We, the Postdoc Professional Development Program (PD2P) leadership team, wrote these postdoc guidelines to be a starting point for communication between new postdocs, their staff mentors, and their managers. These guidelines detail expectations and responsibilities of the three parties, as well as list relevant contacts. The purpose of the Postdoc Program is to bring in talented, creative people who enrich Sandia's environment by performing innovative R&D, as well as by stimulating intellectual curiosity and learning. Postdocs are temporary employees who come to Sandia for career development and advancement reasons. In general, the postdoc term is 1 year, renewable up to five times for a total of six years. However, center practices may vary; check with your manager. At term, a postdoc may apply for a staff position at Sandia or choose to move to university, industry or another lab. It is our vision that those who leave become long-term collaborators and advocates whose relationships with Sandia have a positive effect upon our national constituency.

  14. Essence of the revised guideline for the management of hyperuricemia and gout.

    Science.gov (United States)

    Yamanaka, Hisashi; Metabolism, The Guideline Revising Committee Of Japanese Society Of Gout And Nucleic Acid

    2012-07-01

    Hyperuricemia and gout are common diseases that can be treated by general and family physicians, but with the wide range of diagnosis and treatment departments that treat them, these are diseases for which guidelines are demonstrably useful. Published in 2002 by the Japanese Society of Gout and Nucleic Acid Metabolism in 2002, the Guideline for the Management of Hyperuricemia and Gout was subsequently revised, and in January 2010 the Revised Guideline for the Management of Hyperuricemia and Gout was published. While maintaining the spirit of the original guideline, the revised guideline not only fulfills the prerequisites required for formulating the current guideline but also incorporates new approaches such as the quantification of consensus levels. In addition to emphasizing that hyperuricemia has the duel aspects of being a urate deposition disease and a disease associated with lifestyle diseases, as well as the fact that all hyperuricemia patients require correction of lifestyle habits related to obesity, hypertension, and metabolic syndrome, the revised guideline covers the current evidence in detail. It is the author's sincere hope that this guideline will be utilized effectively in daily medical practice in this field. PMID:25237241

  15. Nurses' experiences of guideline implementation

    DEFF Research Database (Denmark)

    Alanen, Seija; Välimäki, Marita; Kaila, Minna;

    2009-01-01

    adapting of guidelines to local circumstances, seems to be crucial for successful implementation. CONCLUSIONS: Clinical guidelines can be promising tools in enhancing evidence-based nursing practice, as nurses see them as practical work tools in patient care and so are willing to adopt them. However......AIMS: The aim of the study was to address the following questions: What kind of experiences do primary care nurses have of guideline implementation? What do nurses think are the most important factors affecting the adoption of guidelines? BACKGROUND: The implementation of clinical guidelines seems...... to be dependent on multiple context-specific factors. This study sets out to explore the experiences of primary care nurses concerning guideline implementation. DESIGN: Qualitative interview. METHODS: Data were generated by four focus group interviews involving nurses working in out-patient services...

  16. Entanglement quantification by neutron scattering

    Energy Technology Data Exchange (ETDEWEB)

    Marty, Oliver; Plenio, Martin; Cramer, Marcus [Institut fuer Theoretische Physik, Universtitaet Ulm, Ulm (Germany); Epping, Michael; Kampermann, Hermann; Bruss, Dagmar [Institut fuer Theoretische Physik III, Heinrich-Heine Universitaet Duesseldorf, Duesseldorf (Germany)

    2013-07-01

    We present studies about the quantification of the entanglement contained in large samples of magnetic materials by structure factor measurements - a standard tool in analyzing condensed matter systems. We discuss experimentally relevant models (such as Heisenberg, Majumdar-Ghosh and XY models) in different geometries and with different spin numbers. For those, lower bounds to entanglement measures can be read off directly from the cross section obtained in neutron-scattering experiments.

  17. Risk Quantification and Evaluation Modelling

    OpenAIRE

    Manmohan Singh; M.D. Jaybhaye; S. K. Basu

    2014-01-01

    In this paper authors have discussed risk quantification methods and evaluation of risks and decision parameter to be used for deciding on ranking of the critical items, for prioritization of condition monitoring based risk and reliability centered maintenance (CBRRCM). As time passes any equipment or any product degrades into lower effectiveness and the rate of failure or malfunctioning increases, thereby lowering the reliability. Thus with the passage of time or a number of active tests or ...

  18. Computerizing guidelines: factors for success.

    OpenAIRE

    Tierney, W M; Overhage, J. M.; McDonald, C J

    1996-01-01

    Clinical practice guidelines are being touted as a cure for the tension between health care cost and quality. Rather than being just a means of controlling clinicians, guidelines also offer the chance to improve the quality of care by reducing practice variation and adherence to standards of good care. To be operationalized via computers, guidelines must be accepted by the clinicians, who must fully intend to follow them. They must be timely and use available data with minimal additional data...

  19. Toward targeted hypertension screening guidelines

    OpenAIRE

    Buuren, S. van; Boshuizen, HC; Reijneveld, SA

    2006-01-01

    Background. guidelines for screening and subsequent treatment of hypertension vary widely between countries. Part Of this variation can be attributed to systematic differences between Populations, but little is known about the way in which guidelines should be targeted to the population of interest. Optimal guidelines should have high yield and low complexity. The goal is to fit procedures for screening and subsequent treatment of hypertension optimally to a specific population. Methods. Simu...

  20. Mass spectrometry quantification of clusterin in the human brain

    Directory of Open Access Journals (Sweden)

    Chen Junjun

    2012-08-01

    Full Text Available Abstract Background The multifunctional glycoprotein clusterin has been associated with late-onset Alzheimer’s disease (AD. Further investigation to define the role of clusterin in AD phenotypes would be aided by the development of techniques to quantify level, potential post-translational modifications, and isoforms of clusterin. We have developed a quantitative technique based on multiple reaction monitoring (MRM mass spectrometry to measure clusterin in human postmortem brain tissues. Results A stable isotope-labeled concatenated peptide (QconCAT bearing selected peptides from clusterin was expressed with an in vitro translation system and purified. This clusterin QconCAT was validated for use as an internal standard for clusterin quantification using MRM mass spectrometry. Measurements were performed on the human postmortem frontal and temporal cortex from control and severe AD cases. During brain tissues processing, 1% SDS was used in the homogenization buffer to preserve potential post-translational modifications of clusterin. However, MRM quantifications in the brain did not suggest phosphorylation of Thr393, Ser394, and Ser396 residues reported for clusterin in serum. MRM quantifications in the frontal cortex demonstrated significantly higher (P  Conclusions The proposed protocol is a universal quantitative technique to assess expression level of clusterin. It is expected that application of this protocol to quantification of various clusterin isoforms and potential post-translational modifications will be helpful in addressing the role of clusterin in AD.

  1. Improving the application of a practice guideline for the assessment and treatment of suicidal behavior by training the full staff of psychiatric departments via an e-learning supported Train-the-Trainer program: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    de Beurs Derek P

    2013-01-01

    Full Text Available Abstract Background In 2012, in The Netherlands a multidisciplinary practice guideline for the assessment and treatment of suicidal behavior was issued. The release of guidelines often fails to change professional behavior due to multiple barriers. Structured implementation may improve adherence to guidelines. This article describes the design of a study measuring the effect of an e-learning supported Train-the-Trainer program aiming at the training of the full staff of departments in the application of the guideline. We hypothesize that both professionals and departments will benefit from the program. Method In a multicenter cluster randomized controlled trial, 43 psychiatric departments spread over 10 regional mental health institutions throughout The Netherlands will be clustered in pairs with respect to the most prevalent diagnostic category of patients and average duration of treatment. Pair members are randomly allocated to either the experimental or the control condition. In the experimental condition, the full staff of departments, that is, all registered nurses, psychologists, physicians and psychiatrists (n = 532, 21 departments will be trained in the application of the guideline, in a one-day small interactive group Train-the-Trainer program. The program is supported by a 60-minute e-learning module with video vignettes of suicidal patients and additional instruction. In the control condition (22 departments, 404 professionals, the guideline shall be disseminated in the traditional way: through manuals, books, conferences, internet, reviews and so on. The effectiveness of the program will be assessed at the level of both health care professionals and departments. Discussion We aim to demonstrate the effect of training of the full staff of departments with an e-learning supported Train-the-Trainer program in the application of a new clinical guideline. Strengths of the study are the natural setting, the training of full staff, the

  2. Quantification of myocardial perfusion by cardiovascular magnetic resonance

    OpenAIRE

    Jerosch-Herold Michael

    2010-01-01

    Abstract The potential of contrast-enhanced cardiovascular magnetic resonance (CMR) for a quantitative assessment of myocardial perfusion has been explored for more than a decade now, with encouraging results from comparisons with accepted "gold standards", such as microspheres used in the physiology laboratory. This has generated an increasing interest in the requirements and methodological approaches for the non-invasive quantification of myocardial blood flow by CMR. This review provides a...

  3. Reliability and discriminatory power of methods for dental plaque quantification

    OpenAIRE

    Daniela Prócida Raggio; Mariana Minatel Braga; Jonas Almeida Rodrigues; Patrícia Moreira de Freitas; José Carlos Pettorossi Imparato; Fausto Medeiros Mendes

    2010-01-01

    OBJECTIVE: This in situ study evaluated the discriminatory power and reliability of methods of dental plaque quantification and the relationship between visual indices (VI) and fluorescence camera (FC) to detect plaque. MATERIAL AND METHODS: Six volunteers used palatal appliances with six bovine enamel blocks presenting different stages of plaque accumulation. The presence of plaque with and without disclosing was assessed using VI. Images were obtained with FC and digital camera in both cond...

  4. An evidence and consensus based guideline for acute diarrhoea management

    OpenAIRE

    Armon, K; Stephenson, T; MacFaul, R; Eccleston, P; Werneke, U; Baumer, H

    2001-01-01

    OBJECTIVE—To develop an evidence and consensus based guideline for the management of the child who presents to hospital with diarrhoea (with or without vomiting), a common problem representing 16% of all paediatric medical attenders at an accident and emergency department. Clinical assessment, investigations (biochemistry and stool culture in particular), admission, and treatment are addressed. The guideline aims to aid junior doctors in recognising children who need admi...

  5. The German guidelines for incorporation monitoring - need for revision

    International Nuclear Information System (INIS)

    The procedure for monitoring and the assessment of doses due to incorporated radionuclides is laid down in three guidelines drawn up by the Federal Ministry for the Environment, Nature Conservation and Reactor Safety (BMU). The implementation of the Euratom Directive within German law requires that these guidelines be adapted. Within this process, the experience gained during the practical application of these must be taken into account. (orig.)

  6. Clinical Practice Guidelines for Pre-eclampsia and Eclampsia Treatment.

    Directory of Open Access Journals (Sweden)

    Frank Carlos Alvarez Li

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Pre-eclampsia and Eclampsia Treatment. This disease is part of a group of conditions known as hypertensive disease in pregnancy that have in common the existence of high blood pressure. This document includes a review and update of the main clinical aspects, concepts, classification and treatment stressing the use of drugs that cause hypotension and magnesium sulphate. It includes assessment guidelines focused on the most important aspects to be accomplished.

  7. Clinical Practice Guidelines for Vascular Catheter Infections Treatment.

    Directory of Open Access Journals (Sweden)

    Belkys Rodríguez Llerena

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Vascular Catheter Infections Treatment. It has been defined as the presence of local or systemic signs without other obvious infection site, plus the microbiologic evidence involving the catheter. This document includes a review and update of concepts, main clinical aspects, and treatment and stresses the importance of prophylactic treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  8. Clinical Practice Guidelines for postoperative period of thoracic surgery.

    OpenAIRE

    Frank Carlos Alvarez Li; Daniel Olivera Fajardo; Félix Molina Díaz

    2009-01-01

    Clinical Practice Guidelines for postoperative period of thoracic surgery. It is the period between the suture of the surgical wound and the total rehabilitation of the patient, which usually occurs in the Intensive Care Unit. This document includes a review and update of the main aspects such as classification, postoperative treatment, stressing the actions to face any complication. It includes assessment guidelines focused on the most important aspects to be accomplished.

  9. Clinical Practice Guidelines for Vascular Catheter Infections Treatment.

    OpenAIRE

    Belkys Rodríguez Llerena.; Marcos Diosdado Iraola Ferrer

    2009-01-01

    Clinical Practice Guidelines for Vascular Catheter Infections Treatment. It has been defined as the presence of local or systemic signs without other obvious infection site, plus the microbiologic evidence involving the catheter. This document includes a review and update of concepts, main clinical aspects, and treatment and stresses the importance of prophylactic treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  10. Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients.

    Science.gov (United States)

    Ramírez, Juan Carlos; Cura, Carolina Inés; da Cruz Moreira, Otacilio; Lages-Silva, Eliane; Juiz, Natalia; Velázquez, Elsa; Ramírez, Juan David; Alberti, Anahí; Pavia, Paula; Flores-Chávez, María Delmans; Muñoz-Calderón, Arturo; Pérez-Morales, Deyanira; Santalla, José; Marcos da Matta Guedes, Paulo; Peneau, Julie; Marcet, Paula; Padilla, Carlos; Cruz-Robles, David; Valencia, Edward; Crisante, Gladys Elena; Greif, Gonzalo; Zulantay, Inés; Costales, Jaime Alfredo; Alvarez-Martínez, Miriam; Martínez, Norma Edith; Villarroel, Rodrigo; Villarroel, Sandro; Sánchez, Zunilda; Bisio, Margarita; Parrado, Rudy; Maria da Cunha Galvão, Lúcia; Jácome da Câmara, Antonia Cláudia; Espinoza, Bertha; Alarcón de Noya, Belkisyole; Puerta, Concepción; Riarte, Adelina; Diosque, Patricio; Sosa-Estani, Sergio; Guhl, Felipe; Ribeiro, Isabela; Aznar, Christine; Britto, Constança; Yadón, Zaida Estela; Schijman, Alejandro G

    2015-09-01

    An international study was performed by 26 experienced PCR laboratories from 14 countries to assess the performance of duplex quantitative real-time PCR (qPCR) strategies on the basis of TaqMan probes for detection and quantification of parasitic loads in peripheral blood samples from Chagas disease patients. Two methods were studied: Satellite DNA (SatDNA) qPCR and kinetoplastid DNA (kDNA) qPCR. Both methods included an internal amplification control. Reportable range, analytical sensitivity, limits of detection and quantification, and precision were estimated according to international guidelines. In addition, inclusivity and exclusivity were estimated with DNA from stocks representing the different Trypanosoma cruzi discrete typing units and Trypanosoma rangeli and Leishmania spp. Both methods were challenged against 156 blood samples provided by the participant laboratories, including samples from acute and chronic patients with varied clinical findings, infected by oral route or vectorial transmission. kDNA qPCR showed better analytical sensitivity than SatDNA qPCR with limits of detection of 0.23 and 0.70 parasite equivalents/mL, respectively. Analyses of clinical samples revealed a high concordance in terms of sensitivity and parasitic loads determined by both SatDNA and kDNA qPCRs. This effort is a major step toward international validation of qPCR methods for the quantification of T. cruzi DNA in human blood samples, aiming to provide an accurate surrogate biomarker for diagnosis and treatment monitoring for patients with Chagas disease. PMID:26320872

  11. Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients

    Science.gov (United States)

    Ramírez, Juan Carlos; Cura, Carolina Inés; Moreira, Otacilio da Cruz; Lages-Silva, Eliane; Juiz, Natalia; Velázquez, Elsa; Ramírez, Juan David; Alberti, Anahí; Pavia, Paula; Flores-Chávez, María Delmans; Muñoz-Calderón, Arturo; Pérez-Morales, Deyanira; Santalla, José; Guedes, Paulo Marcos da Matta; Peneau, Julie; Marcet, Paula; Padilla, Carlos; Cruz-Robles, David; Valencia, Edward; Crisante, Gladys Elena; Greif, Gonzalo; Zulantay, Inés; Costales, Jaime Alfredo; Alvarez-Martínez, Miriam; Martínez, Norma Edith; Villarroel, Rodrigo; Villarroel, Sandro; Sánchez, Zunilda; Bisio, Margarita; Parrado, Rudy; Galvão, Lúcia Maria da Cunha; da Câmara, Antonia Cláudia Jácome; Espinoza, Bertha; de Noya, Belkisyole Alarcón; Puerta, Concepción; Riarte, Adelina; Diosque, Patricio; Sosa-Estani, Sergio; Guhl, Felipe; Ribeiro, Isabela; Aznar, Christine; Britto, Constança; Yadón, Zaida Estela; Schijman, Alejandro G.

    2015-01-01

    An international study was performed by 26 experienced PCR laboratories from 14 countries to assess the performance of duplex quantitative real-time PCR (qPCR) strategies on the basis of TaqMan probes for detection and quantification of parasitic loads in peripheral blood samples from Chagas disease patients. Two methods were studied: Satellite DNA (SatDNA) qPCR and kinetoplastid DNA (kDNA) qPCR. Both methods included an internal amplification control. Reportable range, analytical sensitivity, limits of detection and quantification, and precision were estimated according to international guidelines. In addition, inclusivity and exclusivity were estimated with DNA from stocks representing the different Trypanosoma cruzi discrete typing units and Trypanosoma rangeli and Leishmania spp. Both methods were challenged against 156 blood samples provided by the participant laboratories, including samples from acute and chronic patients with varied clinical findings, infected by oral route or vectorial transmission. kDNA qPCR showed better analytical sensitivity than SatDNA qPCR with limits of detection of 0.23 and 0.70 parasite equivalents/mL, respectively. Analyses of clinical samples revealed a high concordance in terms of sensitivity and parasitic loads determined by both SatDNA and kDNA qPCRs. This effort is a major step toward international validation of qPCR methods for the quantification of T. cruzi DNA in human blood samples, aiming to provide an accurate surrogate biomarker for diagnosis and treatment monitoring for patients with Chagas disease. PMID:26320872

  12. Climate friendly dietary guidelines

    DEFF Research Database (Denmark)

    Trolle, Ellen; Mogensen, Lisbeth; Thorsen, Anne Vibeke;

    2014-01-01

    The aim of this study was to investigate how the present Danish diet could be changed in a climate friendly direction that follows the recommendations of a healthy diet. The carbon footprint (CF) of an average Danish diet was calculated and compared to CF of a recommended healthy diet by 1......) modifying the average diet according to the Danish food based dietary guidelines, 2) and adjusting to ensure an iso-energy content and a nutrient content according to the Nordic Nutrient Recommendations. Afterwards the healthy diet were changed further to reduce CF. CF from the diet was reduced by 4......%, if the healthy diet was eaten instead of the average current diet. However, if the diet was climate optimized by choosing foods with a low CF within the food groups; meat, vegetables and fruit, CF of this diet may be reduced by 23 % compared to CF of the average diet....

  13. Improved guidelines for RELAP4/MOD6 reflood calculations

    International Nuclear Information System (INIS)

    Computer simulations were performed for an extensive selection of forced- and gravity-feed reflood experiments. This effort was a portion of the assessment procedure for the RELAP4/MOD6 thermal hydraulic computer code. A common set of guidelines, based on recommendations from the code developers, was used in determining the model and user-selected input options for each calculation. The comparison of code-calculated and experimental data was then used to assess the capability of the RELAP4/MOD6 code to model the reflood phenomena. As a result of the assessment, the guidelines for determining the user-selected input options were improved

  14. Guidelines for reliability analysis of digital systems in PSA context. Phase 3. Status report

    International Nuclear Information System (INIS)

    Digital protection and control systems appear as upgrades in older plants, and are commonplace in new nuclear power plants. To assess the risk of nuclear power plant operation and to determine the risk impact of digital systems, there is a need to quantitatively assess the reliability of the digital systems in a justifiable manner. In 2007, the OECD/NEA CSNI directed the Working Group on Risk Assessment (WGRisk) to set up a task group to coordinate an activity in this field. One of the recommendations was to develop a taxonomy of failure modes of digital components for the purposes of probabilistic safety assessment (PSA), resulting in a follow-up task group called DIGREL. The taxonomy will be the basis of future modelling and quantification efforts. It will also help define a structure for data collection and to review PSA studies. This an interim report of the project. A draft guidelines document on the failure modes taxonomy has been developed. The taxonomy is rather complete covering all levels from the system level down to module and basic component level failure modes, including hardware and software aspects. There are still open issues to be resolved by the task group, especially related to I and C unit and module level taxonomy. In a parallel Nordic activity, a comparison of Nordic experiences and a literature review on main international references has been performed. The study showed a wide range of approaches and solutions to the challenges given by digital I and C, and also indicated that no state-of-the-art currently exists. An existing simplified PSA model has been complemented with fault tree models for a four-redundant distributed protection system in order to study and demonstrate the effect of design features and modelling approaches. The model has been used to test the effect of CCF modelling, fail-safe principle and voting logic. A comparison has been made between unit-level and module-level modelling. (Author)

  15. Guidelines for reliability analysis of digital systems in PSA context. Phase 3. Status report

    Energy Technology Data Exchange (ETDEWEB)

    Authen, S. [Risk Pilot AB, Stockholm (Sweden); Holmberg, J.-E. [VTT Technical Research Centre of Finland, Espoo (Finland)

    2013-03-15

    Digital protection and control systems appear as upgrades in older plants, and are commonplace in new nuclear power plants. To assess the risk of nuclear power plant operation and to determine the risk impact of digital systems, there is a need to quantitatively assess the reliability of the digital systems in a justifiable manner. In 2007, the OECD/NEA CSNI directed the Working Group on Risk Assessment (WGRisk) to set up a task group to coordinate an activity in this field. One of the recommendations was to develop a taxonomy of failure modes of digital components for the purposes of probabilistic safety assessment (PSA), resulting in a follow-up task group called DIGREL. The taxonomy will be the basis of future modelling and quantification efforts. It will also help define a structure for data collection and to review PSA studies. This an interim report of the project. A draft guidelines document on the failure modes taxonomy has been developed. The taxonomy is rather complete covering all levels from the system level down to module and basic component level failure modes, including hardware and software aspects. There are still open issues to be resolved by the task group, especially related to I and C unit and module level taxonomy. In a parallel Nordic activity, a comparison of Nordic experiences and a literature review on main international references has been performed. The study showed a wide range of approaches and solutions to the challenges given by digital I and C, and also indicated that no state-of-the-art currently exists. An existing simplified PSA model has been complemented with fault tree models for a four-redundant distributed protection system in order to study and demonstrate the effect of design features and modelling approaches. The model has been used to test the effect of CCF modelling, fail-safe principle and voting logic. A comparison has been made between unit-level and module-level modelling. (Author)

  16. Steam generator tube fitness-for-service guidelines

    International Nuclear Information System (INIS)

    The objectives of this project were to characterize defect mechanisms which could affect the integrity of steam generator tubes, to review and critique state-of-the-art Canadian and international steam generator tube fitness-for-service criteria and guidelines, and to obtain recommendations for criteria that could be used to assess fitness-for service guidelines for steam generator tubes containing defects in Canadian power plant service. Degradation mechanisms, that could affect CANDU steam generator tubes in Canada, have been characterized. The design standards and safety criteria that apply to steam generator tubing in nuclear power plant service in Canada and in Belgium, France, Japan, Spain, Sweden, and the USA have been reviewed and described. The fitness-for-service guidelines used for a variety of specific defect types in Canada and internationally have been evaluated and described in detail in order to highlight the considerations involved in developing such defect specific guidelines. Existing procedures for defect assessment and disposition have been identified, including inspection and examination practices. The approaches used in Canada and in Belgium, France, Japan, Spain, Sweden, and the USA for fitness-for-service guidelines were compared and contrasted for a variety of defect mechanisms. The strengths and weaknesses of the various approaches have been assessed. The report presents recommendations on approaches that may be adopted in the development of fitness-for-service guidelines for use in the dispositioning of steam generator tubing defects in Canada. (author). 175 refs., 2 tabs., 28 figs

  17. Assessing the perceived quality of brachial artery Flow Mediated Dilation studies for inclusion in meta-analyses and systematic reviews: Description of data employed in the development of a scoring ;tool based on currently accepted guidelines.

    Science.gov (United States)

    Greyling, Arno; van Mil, Anke C C M; Zock, Peter L; Green, Daniel J; Ghiadoni, Lorenzo; Thijssen, Dick H

    2016-09-01

    Brachial artery Flow Mediated Dilation (FMD) is widely used as a non-invasive measure of endothelial function. Adherence to expert consensus guidelines on FMD measurement has been found to be of vital importance to obtain reproducible data. This article lists the literature data which was considered in the development of a tool to aid in the objective judgement of the extent to which published studies adhered to expert guidelines for FMD measurement. Application of this tool in a systematic review of FMD studies (http://dx.doi.org/10.1016/j.atherosclerosis.2016.03.011) (Greyling et al., 2016 [1]) indicated that adherence to expert consensus guidelines is strongly correlated to the reproducibility of FMD data. PMID:27284565

  18. APSIC Guidelines for environmental cleaning and decontamination.

    Science.gov (United States)

    Ling, Moi Lin; Apisarnthanarak, Anucha; Thu, Le Thi Anh; Villanueva, Victoria; Pandjaitan, Costy; Yusof, Mohamad Yasim

    2015-01-01

    This document is an executive summary of APSIC Guidelines for Environmental Cleaning and Decontamination. It describes best practices in routine cleaning and decontamination in healthcare facilities as well as in specific settings e.g. management of patients with isolation precautions, food preparation areas, construction and renovation, and following a flood. It recommends the implementation of environmental hygiene program to keep the environment safe for patients, staff and visitors visiting a healthcare facility. Objective assessment of cleanliness and quality is an essential component of this program as a method for identifying quality improvement opportunities. Recommendations for safe handling of linen and bedding; as well as occupational health and safety issues are included in the guidelines. A training program is vital to ensure consistent adherence to best practices. PMID:26719796

  19. The 2005 Dietary Guidelines for Americans and Risk of Metabolic Syndrome

    Science.gov (United States)

    The 2005 Dietary Guidelines for Americans Index (DGAI) was created to assess adherence to the dietary recommendations of the 2005 Dietary Guidelines for Americans (DGA) in relation to chronic disease risk. The objective of the present study was to assess the relationship between dietary patterns con...

  20. Development of a VDI guideline for passive FTIR measurements in the atmosphere

    Science.gov (United States)

    Schäfer, Klaus; Harig, Roland; Blumenstock, Thomas; Höfert, Norbert; Weber, Konradin

    2010-10-01

    A VDI/DIN guideline for passive FTIR spectrometry is under development. The topics will be: Basics of the techniques: principles for the detection of gaseous clouds and exhaust composition, radiative transfer model, radiative temperature, noise equivalent column density and detection limits; Measurement systems: Fourier transform spectroscopy, Michelson interferometers, measurement configurations, spectrometers with one detector element, scanning systems, scanning imaging systems, spectrometers with a detector array; Calibration: radiometric calibration, system calibration; Remote sensing of gases at ambient temperature: basics, identification of gases, quantifications, application examples; Remote sensing of gases at high temperatures: basics, quantification of gas temperature, quantification of composition, application examples; Remote sensing of gases by means of solar radiation: basics, measurement performance, data analyses, application examples.