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Sample records for assessment capability rev

  1. User Instructions for the Systems Assessment Capability, Rev. 1, Computer Codes Volume 3: Utility Codes

    Energy Technology Data Exchange (ETDEWEB)

    Eslinger, Paul W.; Aaberg, Rosanne L.; Lopresti, Charles A.; Miley, Terri B.; Nichols, William E.; Strenge, Dennis L.

    2004-09-14

    This document contains detailed user instructions for a suite of utility codes developed for Rev. 1 of the Systems Assessment Capability. The suite of computer codes for Rev. 1 of Systems Assessment Capability performs many functions.

  2. A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project

    Energy Technology Data Exchange (ETDEWEB)

    Eslinger, Paul W.; Kincaid, Charles T.; Nichols, William E.; Wurstner, Signe K.

    2006-11-06

    The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a

  3. A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project

    International Nuclear Information System (INIS)

    The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a

  4. Tamavidin 2-REV: an engineered tamavidin with reversible biotin-binding capability.

    Science.gov (United States)

    Takakura, Yoshimitsu; Sofuku, Kozue; Tsunashima, Masako

    2013-03-10

    A biotin-binding protein with reversible biotin-binding capability is of great technical value in the affinity purification of biotinylated biomolecules. Although several proteins, chemically or genetically modified from avidin or streptavidin, with reversible biotin-binding have been reported, they have been problematic in one way or another. Tamavidin 2 is a fungal protein similar to avidin and streptavidin in biotin-binding. Here, a mutein, tamavidin 2-REV, was engineered from tamavidin 2 by replacing the serine at position 36 (S36) with alanine. S36 is thought to form a hydrogen bond with biotin in tamavidin 2/biotin complexes and two hydrogen bonds with V38 within the protein. Tamavidin 2-REV bound to biotin-agarose and was eluted with excess free biotin at a neutral pH. In addition, the model substrate biotinylated bovine serum albumin was efficiently purified from a crude extract from Escherichia coli by means of single-step affinity chromatography with tamavidin 2-REV-immobilized resin. Tamavidin 2-REV thus demonstrated reversible biotin-binding capability. The Kd value of tamavidin 2-REV to biotin was 2.8-4.4×10(-7)M.Tamavidin 2-REV retained other convenient characteristics of tamavidin 2, such as high-level expression in E. coli, resistance to proteases, and a neutral isoelectric point, demonstrating that tamavidin 2-REV is a powerful tool for the purification of biotinylated biomolecules. PMID:23333918

  5. Facility Interface Capability Assessment (FICA) project report

    International Nuclear Information System (INIS)

    The US Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is responsible for developing the Civilian Radioactive Waste Management System (CRWMS) to accept spent nuclear fuel from commercial facilities. The objective of the Facility Interface Capability Assessment (FICA) project was to assess the capability of each commercial spent nuclear fuel (SNF) storage facility, at which SNF is stored, to handle various SNF shipping casks. The purpose of this report is to present and analyze the results of the facility assessments completed within the FICA project. During Phase 1, the data items required to complete the facility assessments were identified and the database for the project was created. During Phase 2, visits were made to 122 facilities on 76 sites to collect data and information, the database was updated, and assessments of the cask-handling capabilities at each facility were performed. Each assessment of cask-handling capability contains three parts: the current capability of the facility (planning base); the potential enhanced capability if revisions were made to the facility licensing and/or administrative controls; and the potential enhanced capability if limited physical modifications were made to the facility. The main conclusion derived from the planning base assessments is that the current facility capabilities will not allow handling of any of the FICA Casks at 49 of the 122 facilities evaluated. However, consideration of potential revisions and/or modifications showed that all but one of the 49 facilities could be adapted to handle at least one of the FICA Casks. For this to be possible, facility licensing, administrative controls, and/or physical aspects of the facility would need to be modified

  6. Effects on birds of an offshore wind park at Horns Rev: Environmental impact assessment

    Energy Technology Data Exchange (ETDEWEB)

    Noer, H.; Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [DMU, Dept. of Coastal Zone Ecology (Denmark)

    2000-07-01

    This report presents the technical background to the ornithological environmental impact assessment for the construction of an offshore windpark at Horns Rev, 14 km west-south-west of Blaevandshuk, Denmark. Construction of the park is planned to commence in 2001. The park will consist of c. 80 wind turbines, each of at least 1.8 MW, and cover an area of 27.5 km{sup 2} (including the 200 m exclusion zone around the park). (au)

  7. Assessment of cold neutron radiography capability

    International Nuclear Information System (INIS)

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The authors goals were to demonstrate and assess cold neutron radiography techniques at the Los Alamos Neutron Science Center (LANSCE), Manual Lujan Neutron Scattering Center (Lujan Center), and to investigate potential applications of the capability. The authors have obtained images using film and an amorphous silicon detector. In addition, a new technique they have developed allows neutron radiographs to be made using only a narrow range of neutron energies. Employing this approach and the Bragg cut-off phenomena in certain materials, they have demonstrated material discrimination in radiography. They also demonstrated the imaging of cracks in a sample of a fire-set case that was supplied by Sandia National Laboratory, and they investigated whether the capability could be used to determine the extent of coking in jet engine nozzles. The LANSCE neutron radiography capability appears to have applications in the DOE stockpile maintenance and science-based stockpile stewardship (SBSS) programs, and in industry

  8. Attitude Assessment Using Pleiades-Hr Capabilities

    Science.gov (United States)

    Delevit, J. M.; Greslou, D.; Amberg, V.; Dechoz, C.; de Lussy, F.; Lebegue, L.; Latry, C.; Artigues, S.; Bernard, L.

    2012-07-01

    Since SPOT1, the French national space centre (CNES) has worked on improving the geometry of Earth observation spacecrafts. The accuracy of sensor calibration is one of the main key points for any Earth observation application such as orthorectification, DEM generation or surface change detection. For the last twenty years CNES has developed two families of methods: absolute methods and relative methods. These methods are used to characterize a pushbroom acquisition along the detector line and the time line. By this way, the viewing directions are measured and the residual of the spacecraft's attitude angles (not restituted by the Attitude and Orbit Control System) is estimated. This information can complete the geometric model of all the scenes acquired by the instrument and is used in all geometric applications. This paper presents new attitude assessment methods taking advantage of the capabilities of Pléiades-HR in terms of agility and focal plane arrangement - panchromatic band and multispectral (MS) bands.

  9. Facility Interface Capability Assessment (FICA) user manual

    Energy Technology Data Exchange (ETDEWEB)

    Pope, R.B. [ed.] [Oak Ridge National Lab., TN (United States); MacDonald, R.R. [ed.] [Civilian Radioactive Waste Management System, Vienna, VA (United States); Massaglia, J.L.; Williamson, D.A. [Civilian Radioactive Waste Management System, Vienna, VA (United States); Viebrock, J.M.; Mote, N. [Nuclear Assurance Corp., Norcross, GA (United States)

    1995-09-01

    The US Department of Energy`s (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is responsible for developing the Civilian Radioactive Waste Management System (CRWMS) to accept spent nuclear fuel from commercial facilities. The objective of the Facility Interface Capability Assessment (FICA) project was to assess the capability of each commercial spent nuclear fuel (SNF) storage facility, at which SNF is stored, to handle various SNF shipping casks. The purpose of this report is describe the FICA computer software and to provide the FICA user with a guide on how to use the FICA system. The FICA computer software consists of two executable programs: the FICA Reactor Report program and the FICA Summary Report program (written in the Ca-Clipper version 5.2 development system). The complete FICA software system is contained on either a 3.5 in. (double density) or a 5.25 in. (high density) diskette and consists of the two FICA programs and all the database files (generated using dBASE III). The FICA programs are provided as ``stand alone`` systems and neither the Ca-Clipper compiler nor dBASE III is required to run the FICA programs. The steps for installing the FICA software system and executing the FICA programs are described in this report. Instructions are given on how to install the FICA software system onto the hard drive of the PC and how to execute the FICA programs from the FICA subdirectory on the hard drive. Both FICA programs are menu driven with the up-arrow and down-arrow keys used to move the cursor to the desired selection.

  10. Facility Interface Capability Assessment (FICA) user manual

    International Nuclear Information System (INIS)

    The US Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is responsible for developing the Civilian Radioactive Waste Management System (CRWMS) to accept spent nuclear fuel from commercial facilities. The objective of the Facility Interface Capability Assessment (FICA) project was to assess the capability of each commercial spent nuclear fuel (SNF) storage facility, at which SNF is stored, to handle various SNF shipping casks. The purpose of this report is describe the FICA computer software and to provide the FICA user with a guide on how to use the FICA system. The FICA computer software consists of two executable programs: the FICA Reactor Report program and the FICA Summary Report program (written in the Ca-Clipper version 5.2 development system). The complete FICA software system is contained on either a 3.5 in. (double density) or a 5.25 in. (high density) diskette and consists of the two FICA programs and all the database files (generated using dBASE III). The FICA programs are provided as ''stand alone'' systems and neither the Ca-Clipper compiler nor dBASE III is required to run the FICA programs. The steps for installing the FICA software system and executing the FICA programs are described in this report. Instructions are given on how to install the FICA software system onto the hard drive of the PC and how to execute the FICA programs from the FICA subdirectory on the hard drive. Both FICA programs are menu driven with the up-arrow and down-arrow keys used to move the cursor to the desired selection

  11. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  12. Analytical Chemistry Core Capability Assessment - Preliminary Report

    Energy Technology Data Exchange (ETDEWEB)

    Barr, Mary E. [Los Alamos National Laboratory; Farish, Thomas J. [Los Alamos National Laboratory

    2012-05-16

    The concept of 'core capability' can be nebulous one. Even at a fairly specific level, where core capability equals maintaining essential services, it is highly dependent upon the perspective of the requestor. Samples are submitted to analytical services because the requesters do not have the capability to conduct adequate analyses themselves. Some requests are for general chemical information in support of R and D, process control, or process improvement. Many analyses, however, are part of a product certification package and must comply with higher-level customer quality assurance requirements. So which services are essential to that customer - just those for product certification? Does the customer also (indirectly) need services that support process control and improvement? And what is the timeframe? Capability is often expressed in terms of the currently utilized procedures, and most programmatic customers can only plan a few years out, at best. But should core capability consider the long term where new technologies, aging facilities, and personnel replacements must be considered? These questions, and a multitude of others, explain why attempts to gain long-term consensus on the definition of core capability have consistently failed. This preliminary report will not try to define core capability for any specific program or set of programs. Instead, it will try to address the underlying concerns that drive the desire to determine core capability. Essentially, programmatic customers want to be able to call upon analytical chemistry services to provide all the assays they need, and they don't want to pay for analytical chemistry services they don't currently use (or use infrequently). This report will focus on explaining how the current analytical capabilities and methods evolved to serve a variety of needs with a focus on why some analytes have multiple analytical techniques, and what determines the infrastructure for these analyses. This

  13. Analytical Chemistry Core Capability Assessment - Preliminary Report

    International Nuclear Information System (INIS)

    The concept of 'core capability' can be nebulous one. Even at a fairly specific level, where core capability equals maintaining essential services, it is highly dependent upon the perspective of the requestor. Samples are submitted to analytical services because the requesters do not have the capability to conduct adequate analyses themselves. Some requests are for general chemical information in support of R and D, process control, or process improvement. Many analyses, however, are part of a product certification package and must comply with higher-level customer quality assurance requirements. So which services are essential to that customer - just those for product certification? Does the customer also (indirectly) need services that support process control and improvement? And what is the timeframe? Capability is often expressed in terms of the currently utilized procedures, and most programmatic customers can only plan a few years out, at best. But should core capability consider the long term where new technologies, aging facilities, and personnel replacements must be considered? These questions, and a multitude of others, explain why attempts to gain long-term consensus on the definition of core capability have consistently failed. This preliminary report will not try to define core capability for any specific program or set of programs. Instead, it will try to address the underlying concerns that drive the desire to determine core capability. Essentially, programmatic customers want to be able to call upon analytical chemistry services to provide all the assays they need, and they don't want to pay for analytical chemistry services they don't currently use (or use infrequently). This report will focus on explaining how the current analytical capabilities and methods evolved to serve a variety of needs with a focus on why some analytes have multiple analytical techniques, and what determines the infrastructure for these analyses. This information will be

  14. Emergency Response Capability Baseline Needs Assessment Compliance Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Sharry, John A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2013-09-16

    This document is the second of a two-part analysis of Emergency Response Capabilities of Lawrence Livermore National Laboratory. The first part, 2013 Baseline Needs Assessment Requirements Document established the minimum performance criteria necessary to meet mandatory requirements. This second part analyses the performance of Lawrence Livermore Laboratory Emergency Management Department to the contents of the Requirements Document. The document was prepared based on an extensive review of information contained in the 2009 BNA, the 2012 BNA document, a review of Emergency Planning Hazards Assessments, a review of building construction, occupancy, fire protection features, dispatch records, LLNL alarm system records, fire department training records, and fire department policies and procedures.

  15. RHIC Critical Point Search: Assessing STAR's Capabilities

    OpenAIRE

    Sorensen, Paul

    2007-01-01

    In this report we discuss the capabilities and limitations of the STAR detector to search for signatures of the QCD critical point in a low energy scan at RHIC. We find that a RHIC low energy scan will cover a broad region of interest in the nuclear matter phase diagram and that the STAR detector -- a detector designed to measure the quantities that will be of interest in this search -- will provide new observables and improve on previous measurements in this energy range.

  16. Assessment of Emergency Management Performance and Capability

    OpenAIRE

    Jones, Brian J

    2003-01-01

    Hazardous industries in the UK and Europe are under pressure to increase the transparency and accountability of the ways in which they manage their hazards and the risks they pose to the population and environment. The literature has indicated that the field would benefit from a risk-based, continuous improvement approach to emergency management in hazardous industry. The aim of this research was to construct a framework to enable assessment of the emergency management pe...

  17. Assessment of NASA's Aircraft Noise Prediction Capability

    Science.gov (United States)

    Dahl, Milo D. (Editor)

    2012-01-01

    A goal of NASA s Fundamental Aeronautics Program is the improvement of aircraft noise prediction. This document provides an assessment, conducted from 2006 to 2009, on the current state of the art for aircraft noise prediction by carefully analyzing the results from prediction tools and from the experimental databases to determine errors and uncertainties and compare results to validate the predictions. The error analysis is included for both the predictions and the experimental data and helps identify where improvements are required. This study is restricted to prediction methods and databases developed or sponsored by NASA, although in many cases they represent the current state of the art for industry. The present document begins with an introduction giving a general background for and a discussion on the process of this assessment followed by eight chapters covering topics at both the system and the component levels. The topic areas, each with multiple contributors, are aircraft system noise, engine system noise, airframe noise, fan noise, liner physics, duct acoustics, jet noise, and propulsion airframe aeroacoustics.

  18. Utility Assessment Report for SPIDERS Phase 2: Ft. Carson (Rev 1.0)

    Energy Technology Data Exchange (ETDEWEB)

    Barr, Jonathan L.; Tuffner, Francis K.; Hadley, Mark D.; Schneider, Kevin P.

    2014-01-01

    This document contains the Utility Assessment Report (UAR) for the Phase 2 operational Demonstration (OD) of the Smart Power Infrastructure Demonstration for Energy Reliability and Security (SPIDERS) Joint Capability Technology Demonstration (JCTD). The UAR for Phase 2 shows that the SPIDERS system was able to meet the requirements of the Implementation Directive at Ft. Carson.

  19. Horns Rev offshore wind power farm. Environmental impact assessment on water quality

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, Per

    2000-05-15

    As part of an overall Environmental Impact Assessment (EIA) undertaken in connection with a planned 150 MW offshore wind farm at Horns Rev, an assessment was made of the effects the wind farm would have on the water quality in the area. This EIA study was drawn up in accordance with the guidelines laid down by the Danish Ministry of Environment and Energy in the publication 'Guidelines for the preparation of EIA studies for offshore wind farms'. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. Only local and minor changes are anticipated in connection with the currents, sediments and wave conditions during the production phase. These will occur in the immediate vicinity of the individual foundations. For these reasons, no changes are expected in the water quality. This also includes also the pelagic primary production and the occurrence of plankton in the area. Increased local copper contamination of phytoplankton and zooplankton may be expected during the production phase, as a result of the total annual discharge of 206 kg copper from the slip-rings in the wind turbines. The contamination will potentially result in a local reduction of the pelagic primary production and changes in the species composition of the plankton. The wind turbines will be sandblasted and painted once during their lifetime, as part of the routine maintenance. The sandblasting and painting will lead to a temporary spill of paint, paint waste and sand. The impacts on water quality and plankton production are unknown. It is recommended that factors such as the toxicity of the paint be investigated, and that spills and the impact of waste be reduced as much as possible. The water quality and the plankton in the wind farm area and along the cable line's passage to shore through the international protected area, will only be

  20. Performance Analysis of the Capability Assessment Tool for Sustainable Manufacturing

    Directory of Open Access Journals (Sweden)

    Enda Crossin

    2013-08-01

    Full Text Available This paper explores the performance of a novel capability assessment tool, developed to identify capability gaps and associated training and development requirements across the supply chain for environmentally-sustainable manufacturing. The tool was developed to assess 170 capabilities that have been clustered with respect to key areas of concern such as managing energy, water, material resources, carbon emissions and waste as well as environmental management practices for sustainability. Two independent expert teams used the tool to assess a sample group of five first and second tier sports apparel and footwear suppliers within the supply chain of a global sporting goods manufacturer in Asia. The paper addresses the reliability and robustness of the developed assessment method by formulating the expected links between the assessment results. The management practices of the participating suppliers were shown to be closely connected to their performance in managing their resources and emissions. The companies’ initiatives in implementing energy efficiency measures were found to be generally related to their performance in carbon emissions management. The suppliers were also asked to undertake a self-assessment by using a short questionnaire. The large gap between the comprehensive assessment and these in-house self-assessments revealed the suppliers’ misconceptions about their capabilities.

  1. An Integrated Knowledge Management Capabilities Framework for Assessing Organizational Performance

    Directory of Open Access Journals (Sweden)

    Abdel Nasser H. Zaied

    2012-03-01

    Full Text Available In the present aggressive world of competition, knowledge management strategies are becoming the major vehicle for the organizations to achieve their goals; to compete and to perform well. Linking knowledge management to business performance could make a strong business case in convincing senior management of any organization about the need to adopt a knowledge management strategy. Organizational performance is, therefore, a key issue and performance measurement models provide a basis for developing a structured approach to knowledge management. In this respect, organizations need to assess their knowledge management capabilities and find ways to improve their performance. This paper takes these issues into account when study the role of knowledge management in enhancing the organizational performance and consequently, developed an integrated knowledge management capabilities framework for assessing organizational performance. The results show that there is positive correlation between knowledge management capabilities and organizational performance. The results also show that the proposed framework can be used to assess organizational performance and also can be used as decision tool to decide which knowledge management capability should be improved.

  2. Bayesian Assessment of Accuracy Properties of Rose Bengal Test in REV-1 Vaccinated Small Ruminants

    Directory of Open Access Journals (Sweden)

    KUJTIM MERSINAJ

    2015-12-01

    Full Text Available The live Brucella melitensis Rev-1 strain is considered the best vaccine available for the prevention of brucellosis in small ruminants. In Albania, vaccination of small ruminants with REV-1 has been used under various regimes since 2004. The effectiveness of the vaccination campaigns is monitored through a post vaccination monitoring and surveillance system based on testing vaccinated animals with Rose Bengal Plate Test (RBPT. Regrettably the test accuracy properties such as the sensitivity and specificity have not been validated in vaccinated small ruminants. The lack of knowledge on these properties hampers the correct evaluation of the true sero-conversion rate of the post vaccination monitoring at national and at flock scale. This study addressed this issue by using a Bayesian modelling framework to estimate two serological tests the RBPT which is the standard serological test used in the post vaccination monitoring and Complement Fixation Test (CFT. Serum samples from 191 reportedly vaccinated small ruminants were tested in parallel with RBPT and CFT. The estimates of sensitivity and specificity values of RBPT were 91% (95% CrI: 82 -98 and 89% (95% CrI: 70 - 98. For CFT the sensitivity resulted 86% (95% CrI: 70 - 95 and the specificity 95% (95% CrI: 80 - 99. The good sensitivity and acceptable specificity of RBPT support its utilization as screening test for post vaccination monitoring. The interpretation of the post vaccination data with RBPT are well acceptable at national level but not well suited for flock status interpretation. In terms of disease diagnosis, especially for a latter phase of the brucellosis control strategy in Albania, both tests could justify their use in association.

  3. Survey of Biomass Resource Assessments and Assessment Capabilities in APEC Economies

    Energy Technology Data Exchange (ETDEWEB)

    Milbrandt, A.; Overend, R. P

    2008-11-01

    This survey of biomass resource assessments and assessment capabilities in Asia-Pacific Economic Cooperation (APEC) economies considered various sources: academic and government publications, media reports, and personal communication with contacts in member economies.

  4. Capabilities For Modelling Of Conversion Processes In Life Cycle Assessment

    DEFF Research Database (Denmark)

    Damgaard, Anders; Zarrin, Bahram; Tonini, Davide;

    Life cycle assessment was traditionally used for modelling of product design and optimization. This is also seen in the conventional LCA software which is optimized for the modelling of single materials streams of a homogeneous nature that is assembled into a final product. There has therefore been...... treatment and waste management, the material being addressed is of a very heterogeneous nature. This heterogeneity is seen both between treatment facilities receiving materials with different compositions, but also at the individual treatment facility where the temporal composition of a treated material...... being handled. These chemical substances can then be traced through the different processes similarly to substance flow assessment, but with the added options to address emissions, material and energy usage through each process step. However, it was found that further capabilities were needed, when...

  5. Mission Adaptive Uas Capabilities for Earth Science and Resource Assessment

    Science.gov (United States)

    Dunagan, S.; Fladeland, M.; Ippolito, C.; Knudson, M.; Young, Z.

    2015-04-01

    Unmanned aircraft systems (UAS) are important assets for accessing high risk airspace and incorporate technologies for sensor coordination, onboard processing, tele-communication, unconventional flight control, and ground based monitoring and optimization. These capabilities permit adaptive mission management in the face of complex requirements and chaotic external influences. NASA Ames Research Center has led a number of Earth science remote sensing missions directed at the assessment of natural resources and here we describe two resource mapping problems having mission characteristics requiring a mission adaptive capability extensible to other resource assessment challenges. One example involves the requirement for careful control over solar angle geometry for passive reflectance measurements. This constraint exists when collecting imaging spectroscopy data over vegetation for time series analysis or for the coastal ocean where solar angle combines with sea state to produce surface glint that can obscure the signal. Furthermore, the primary flight control imperative to minimize tracking error should compromise with the requirement to minimize aircraft motion artifacts in the spatial measurement distribution. A second example involves mapping of natural resources in the Earth's crust using precision magnetometry. In this case the vehicle flight path must be oriented to optimize magnetic flux gradients over a spatial domain having continually emerging features, while optimizing the efficiency of the spatial mapping task. These requirements were highlighted in recent Earth Science missions including the OCEANIA mission directed at improving the capability for spectral and radiometric reflectance measurements in the coastal ocean, and the Surprise Valley Mission directed at mapping sub-surface mineral composition and faults, using high-sensitivity magnetometry. This paper reports the development of specific aircraft control approaches to incorporate the unusual and

  6. Fire fighting capability assessment program Bruce B NGS

    International Nuclear Information System (INIS)

    This is a report on the completion of work relating to the assessment of the capability of Bruce B NGS to cope with a large fire incident. This included an evaluation of an exercise scenario that would simulate a large fire incident and of their fire plans and procedures. Finally the execution of fire plans by Bruce B NGS, as demonstrated by their application of human and material resources during a simulated large fire, was observed. The fire fighting equipment and the personal protective clothing and associated equipment that was in use was all of good quality and in good condition. There had also been notable improvement in communications equipment. Similarly, the human resources that had been assigned to fire fighting and rescue crews and that were available were more than adequate. Use of a logical incident command system, and the adoption of proper policy and procedures for radio communications were equally significant improvements. Practice should correct the breakdowns that occurred in these areas during the exercise. As well, there remains a need for the development of policy on fire fighting and rescue operations with more depth and clarity. In summary, the key point to be recognized is the degree of improvement that has been realized since the previous evaluation in 1990. Clearly the Emergency Response Teams organization of Bruce B NGS is evolving into an effective fire fighting force. Providing that the deficiencies identified in this report are addressed satisfactorily, Fire Cross is confident that the organization will have the capability to provide rescue and fire fighting services that will satisfy the need. 2 figs

  7. Thermal Imaging Assessment of Cicatrical Tissue Capabilities in Facioplasty Planning

    Directory of Open Access Journals (Sweden)

    N.L. Korotkova

    2015-06-01

    Full Text Available The aim of the investigation was to study the capabilities of thermal imaging to estimate the functional reserves of blood supply of facial cicatricial tissues used in skin grafting. Materials and Methods. Using an infrared thermal imager Thermo Tracer ТН-9100 we examined 37 patients with post-burn scars on the face and anterior surface of the neck (total: 126 scar areas planned for flap dissection and 4 healthy volunteers. After recording a native (original thermal picture, we carried out a standard local alcohol test with further monitoring of space-time temperature dynamics for 7 min. To develop a criterion of tissue suitability for skin grafting, we calculated ∆Т=Тinit–Тfin, where Тinit was the initial temperature before the test, and Тfin — the temperature on the 7th minute of test recovery. Results. The obtained data on the thermal reaction dynamics of cicatricial tissues enable to evaluate the capability to use these tissues as skin grafting material. The criteria are based on thermal imaging findings of the dynamics of initial temperature recovery of healthy and cicatrical tissues. If the temperature difference by the 7th minute of the examined tissues is below 0.9°С by the end of the alcohol test, the tissues can be used for skin grafting. The temperature recovery lag by more than 1.9°С indicates inapplicability of cicatricial tissues for skin grafting. The temperature difference in the range from 0.9 to 1.9°С should be considered risky. Conclusion. The developed thermal image technique to assess the functional state of facial cicatricial tissue blood supply enables to determine the criteria of cicatrical tissue availability for minor facioplasty, and differentiate suitable and unsuitable tissues.

  8. Synopsis report : environmental oil spill risk assessment for the south coast of Newfoundland. Rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-11-06

    This study was conducted to assess the risks of oil pollution as a result of marine traffic in Canadian waters off the south coast of Newfoundland. The oil included crude oil, fuel oil sludge, oil refuse, and refined products carried by vessels. The probability of an oil spill occurring was assessed, as well as the consequences of potential spills. A 2-phase approach was used. An initial estimate was made using existing data, and the estimates were then reviewed and validated using a peer review process. The review included studies by independent experts and a consultation process involving authorities responsible for managing marine traffic in the area. The report described stakeholder consultations, oil spill scenarios, and potential changes in activity over the next 10 years. Estimates of the potential effect of oil spills on key species were provided, as well as estimates of the potential economic consequences of a significant oil spill. An estimate of the overall risk in the region was included. 39 tabs., 4 figs.

  9. Blast overpressure and fallout radiation dose models for casualty assessment and other purposes. Rev. ed.

    International Nuclear Information System (INIS)

    The determination of blast overpressures and fallout radiation doses at points on a sufficiently fine grid, for any part or for the whole of the UK, and for any postulated attack, is an essential element in the systematic assessment of casualties, the estimation of numbers of homeless, and the evaluation of life-saving measures generally. Models are described which provide the required blast and dose values and which are intended to supersede existing models which were introduced in 1971. The factors which affect blast and, more particularly, dose values are discussed, and the way in which various factors are modelled is described. The models are incorporated into separate computer programs which are described, the outputs of which are stored on magnetic tape for subsequent use as required. (author)

  10. Kozloduy nuclear power plant. Units 1-4. Status of safety assessment activities. Rev. 2

    International Nuclear Information System (INIS)

    This paper presents the results of the status of safety assessment activities carried out by the Kozloduy Nuclear Power Plant (KNPP) in order to evaluate the current status of the safety of its reactor units 1-4. The steam supply system of this units is based of the reactor WWER-440/ B-230, which is a PWR of Russian design developed according to the safety standards in force in USSR in late 60-s. Now a days 10 reactor units of this type are in operation in four NPPs. Despite of efforts of the different plants to implement safety improvements measures during first 10-15 years of operation of this type of reactor its major safety problems were not eliminated and were a subject of international concern. The systematic evaluation of the deficiencies of the original design of this type of reactors have been initiated by IAEA in the beginning of 1990 and brought to developing a comprehensive list of safety problems which required urgent implementation of safety measures in all plants. To solve this problems in 1991 KNPP initiated implementation of so called 'short term' safety improvement program, developed with the help of WANO under agreement with Bulgarian Nuclear Safety Authority (BNSA) and consortium RISKAUDIT. The program was based on a stage approach and was foreseen to be implemented by tree stages in very tight time schedule in order to achieve significant and rapid improvements of the level of safety in operation of the units. The Short Tenn Program was implemented between the years 1991 and 1997 thanks of the strong safety commitment of NEK and KNPP staff and the broad international cooperation and financial support. Important part of resources were supplied under PHARE program of CEC, EBRD grant agreement and EDF support. The plant current safety level analysis has been performed using IAEA analytical methodology according to 50-SG-O12 standard 'Periodic safety review of operational nuclear power plants'. The approach and criteria for acceptable safety level

  11. Assessment of Modeling Capability for Reproducing Storm Impacts on TEC

    Science.gov (United States)

    Shim, J. S.; Kuznetsova, M. M.; Rastaetter, L.; Bilitza, D.; Codrescu, M.; Coster, A. J.; Emery, B. A.; Foerster, M.; Foster, B.; Fuller-Rowell, T. J.; Huba, J. D.; Goncharenko, L. P.; Mannucci, A. J.; Namgaladze, A. A.; Pi, X.; Prokhorov, B. E.; Ridley, A. J.; Scherliess, L.; Schunk, R. W.; Sojka, J. J.; Zhu, L.

    2014-12-01

    During geomagnetic storm, the energy transfer from solar wind to magnetosphere-ionosphere system adversely affects the communication and navigation systems. Quantifying storm impacts on TEC (Total Electron Content) and assessment of modeling capability of reproducing storm impacts on TEC are of importance to specifying and forecasting space weather. In order to quantify storm impacts on TEC, we considered several parameters: TEC changes compared to quiet time (the day before storm), TEC difference between 24-hour intervals, and maximum increase/decrease during the storm. We investigated the spatial and temporal variations of the parameters during the 2006 AGU storm event (14-15 Dec. 2006) using ground-based GPS TEC measurements in the selected 5 degree eight longitude sectors. The latitudinal variations were also studied in two longitude sectors among the eight sectors where data coverage is relatively better. We obtained modeled TEC from various ionosphere/thermosphere (IT) models. The parameters from the models were compared with each other and with the observed values. We quantified performance of the models in reproducing the TEC variations during the storm using skill scores. This study has been supported by the Community Coordinated Modeling Center (CCMC) at the Goddard Space Flight Center. Model outputs and observational data used for the study will be permanently posted at the CCMC website (http://ccmc.gsfc.nasa.gov) for the space science communities to use.

  12. Assessing the weather monitoring capabilities of cellular microwave link networks

    Science.gov (United States)

    Fencl, Martin; Vrzba, Miroslav; Rieckermann, Jörg; Bareš, Vojtěch

    2016-04-01

    Using of microwave links for rainfall monitoring was suggested already by (Atlas and Ulbrich, 1977). However, this technique attracted broader attention of scientific community only in the recent decade, with the extensive growth of cellular microwave link (CML) networks, which form the backbone of today's cellular telecommunication infrastructure. Several studies have already shown that CMLs can be conveniently used as weather sensors and have potential to provide near-ground path-integrated observations of rainfall but also humidity or fog. However, although research is still focusing on algorithms to improve the weather sensing capabilities (Fencl et al., 2015), it is not clear how to convince cellular operators to provide the power levels of their network. One step in this direction is to show in which regions or municipalities the networks are sufficiently dense to provide/develop good services. In this contribution we suggest a standardized approach to evaluate CML networks in terms of rainfall observation and to identify suitable regions for CML rainfall monitoring. We estimate precision of single CML based on its sensitivity to rainfall, i.e. as a function of frequency, polarization and path length. Capability of a network to capture rainfall spatial patterns is estimated from the CML coverage and path lengths considering that single CML provides path-integrated rain rates. We also search for suitable predictors for regions where no network topologies are available. We test our approach on several European networks and discuss the results. Our results show that CMLs are very dense in urban areas (> 1 CML/km2), but less in rural areas (population and CML network density (e.g. R2 = 0.97 in Czech Republic), thus population could be a simple proxy to identify suitable regions for CML weather monitoring. To enable a simple and efficient assessment of the CML monitoring potential for any region worldwide, we are currently integrating our approach into open source

  13. Excess science accommodation capabilities and excess performance capabilities assessment for Mars Geoscience and Climatology Orbiter: Extended study

    Science.gov (United States)

    Clark, K.; Flacco, A.; Kaskiewicz, P.; Lebsock, K.

    1983-01-01

    The excess science accommodation and excess performance capabilities of a candidate spacecraft bus for the Mars Geoscience and Climatology Orbiter MGCO mission are assessed. The appendices are included to support the conclusions obtained during this contract extension. The appendices address the mission analysis, the attitude determination and control, the propulsion subsystem, and the spacecraft configuration.

  14. Developing an International Survey of Teachers' Assessment Capabilities

    DEFF Research Database (Denmark)

    Renken, Maggie; Otrel-Cass, Kathrin; Cowie, Bronwen;

    Professional standards require teachers to be assessment literate - to construct, administer, and score reliable, valid assessments, communicate interpretations and use evidence to adjust teaching to support students. This project investigates student-teachers’ assessment literacy throughout...... across four New Zealand universities (Hill, et al. 2013)....

  15. A framework study on assessment of mass customization capabilities

    DEFF Research Database (Denmark)

    Nielsen, Kjeld; Brunø, Thomas Ditlev; Jørgensen, Kaj Asbjørn

    2012-01-01

    Much research has been done to assist industries to move from mass production to mass customization. Salvador F., et al. made it clear in the article “Cracking the code of Mass Customization”, that becoming a Mass Customizer is not a single step quick fix, but requires 3 fundamental capabilities....

  16. Assessment of Space Nuclear Thermal Propulsion Facility and Capability Needs

    Energy Technology Data Exchange (ETDEWEB)

    James Werner

    2014-07-01

    The development of a Nuclear Thermal Propulsion (NTP) system rests heavily upon being able to fabricate and demonstrate the performance of a high temperature nuclear fuel as well as demonstrating an integrated system prior to launch. A number of studies have been performed in the past which identified the facilities needed and the capabilities available to meet the needs and requirements identified at that time. Since that time, many facilities and capabilities within the Department of Energy have been removed or decommissioned. This paper provides a brief overview of the anticipated facility needs and identifies some promising concepts to be considered which could support the development of a nuclear thermal propulsion system. Detailed trade studies will need to be performed to support the decision making process.

  17. Thermal Imaging Assessment of Cicatrical Tissue Capabilities in Facioplasty Planning

    OpenAIRE

    N.L. Korotkova; М.G. Volovik

    2015-01-01

    The aim of the investigation was to study the capabilities of thermal imaging to estimate the functional reserves of blood supply of facial cicatricial tissues used in skin grafting. Materials and Methods. Using an infrared thermal imager Thermo Tracer ТН-9100 we examined 37 patients with post-burn scars on the face and anterior surface of the neck (total: 126 scar areas planned for flap dissection) and 4 healthy volunteers. After recording a native (original) thermal picture, we carried ...

  18. Review report 2004. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-10-15

    The present review report presents the two wind farms Horns Rev and Nysted with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on method, programmes and conclusions can be found in these reports (see Appendix 1). This review report is divided into two parts. The first part contains a description of the potential environmental impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Horns Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated in the Roedsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

  19. What am I capable? Self-Assessment of Basic Competences

    Directory of Open Access Journals (Sweden)

    Antonia Ramírez García

    2014-10-01

    Full Text Available The aims of this research are focus in evaluate linguistic communication and mathematics competences of students in sixth grade of primary education from their perception, and to develop a valid and reliable questionnaire in order to perform a self-assessment. The methodology has quantitative, descriptive and correlational character. In this research 1424 students from 46 schools in Cordova and its province participated. The results show that variables such as gender, age, number of siblings and type of center have influence for a better or worse self-assessment of students; but extracurricular activities undertaken by students and the increased weekly time devoted are those which cause a greater appreciation of each competence. On the other hand, a lower daily use of television, computer and games console allows that students make a self-assess more capeble to different aspects of both competences.

  20. Lawrence Livermore National Laboratory Emergency Response Capability 2009 Baseline Needs Assessment Performance Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Sharry, J A

    2009-12-30

    This document was prepared by John A. Sharry, LLNL Fire Marshal and Division Leader for Fire Protection and was reviewed by Sandia/CA Fire Marshal, Martin Gresho. This document is the second of a two-part analysis of Emergency Response Capabilities of Lawrence Livermore National Laboratory. The first part, 2009 Baseline Needs Assessment Requirements Document established the minimum performance criteria necessary to meet mandatory requirements. This second part analyses the performance of Lawrence Livermore Laboratory Emergency Management Department to the contents of the Requirements Document. The document was prepared based on an extensive review of information contained in the 2004 BNA, a review of Emergency Planning Hazards Assessments, a review of building construction, occupancy, fire protection features, dispatch records, LLNL alarm system records, fire department training records, and fire department policies and procedures. On October 1, 2007, LLNL contracted with the Alameda County Fire Department to provide emergency response services. The level of service called for in that contract is the same level of service as was provided by the LLNL Fire Department prior to that date. This Compliance Assessment will evaluate fire department services beginning October 1, 2008 as provided by the Alameda County Fire Department.

  1. An Innovative Tool to Assess Marketing Capabilities of Traditional Producers within the European Food Industry

    OpenAIRE

    Banterle, Alessandro; Carraresi, Laura; Stranieri, Stefanella

    2008-01-01

    The purpose of this paper is to assess the marketing management capabilities of SMEs producing traditional food products in EU throughout the development of a benchmarking tool. SMEs represent the greater part of European food firms and they find it very difficult to adapt to market changes, and to compete with big enterprises. In this context, marketing management plays a key role in good SMEs performances in the market. The benchmarking tool, utilised to assess marketing capabilities, is ai...

  2. Assessing Preservice Teachers' Presentation Capabilities: Contrasting the Modes of Communication with the Constructed Impression

    Science.gov (United States)

    Bower, Matt G.; Moloney, Robyn A.; Cavanagh, Michael S.; Sweller, Naomi

    2013-01-01

    A research-based understanding of how to develop and assess classroom presentation skills is vital for the effective development of pre-service teacher communication capabilities. This paper identifies and compares two different models of assessing pre-service teachers' presentation performance--one based on the Modes of Communication (voice,…

  3. Assessment of Static Delamination Propagation Capabilities in Commercial Finite Element Codes Using Benchmark Analysis

    Science.gov (United States)

    Orifici, Adrian C.; Krueger, Ronald

    2010-01-01

    With capabilities for simulating delamination growth in composite materials becoming available, the need for benchmarking and assessing these capabilities is critical. In this study, benchmark analyses were performed to assess the delamination propagation simulation capabilities of the VCCT implementations in Marc TM and MD NastranTM. Benchmark delamination growth results for Double Cantilever Beam, Single Leg Bending and End Notched Flexure specimens were generated using a numerical approach. This numerical approach was developed previously, and involves comparing results from a series of analyses at different delamination lengths to a single analysis with automatic crack propagation. Specimens were analyzed with three-dimensional and two-dimensional models, and compared with previous analyses using Abaqus . The results demonstrated that the VCCT implementation in Marc TM and MD Nastran(TradeMark) was capable of accurately replicating the benchmark delamination growth results and that the use of the numerical benchmarks offers advantages over benchmarking using experimental and analytical results.

  4. Assessment of capability index of processes revealing significant asymmetry with respect to tolerance limits

    Directory of Open Access Journals (Sweden)

    L. Bukowski

    2010-07-01

    Full Text Available The paper presents an analysis of basic capability indices for production processes, Cp and Cpk, as well as the Cpm index for processes asymmetric with respect to tolerance limits. A method is presented for the estimation of process admissible asymmetry, when anappropriate PPM level of defective products is to be maintained. It is proved that an unbiased capability assessment for asymmetricprocesses is only feasible if the pair of indices Cp and Cpk is included in the assessment. An example is given of an analysis of data on the production of automotive bearings. The computations were performed with use of the KWSPP program.

  5. Spent fuel shipping cask handling capability assessment of 27 selected light water reactors

    International Nuclear Information System (INIS)

    This report presents an assessment of the spent fuel shipping cask handling capabilities of those nuclear plants currently projected to lose full core reserve capability in their spent fuel storage basins in the near future. The purpose of this assessment is to determine which cask types, in the current fleet, each of the selected reactors can handle. The cask handling capability of a nuclear plant depends upon both external and internal conditions at the plant. The availability of a rail spur, the lifting capacity of the crane, the adequacy of clearances in the cask receiving, loading, and decontamination areas and similar factors can limit the types of casks that can be utilized at a particular plant. This report addresses the major facility capabilities used in assessing the types of spent fuel shipping casks that can be handled at each of the 27 selected nuclear plants approaching a critical storage situation. The results of this study cannot be considered to be final and are not intended to be used to force utilities to ship by a particular mode. In addition, many utilities have never shipped spent fuel. Readers are cautioned that the results of this study reflect the current situation at the selected plants and are based on operator perceptions and guidance from NRC related to the control of heavy loads at nuclear power plants. Thus, the cask handling capabilities essentially represent snap-shots in time and could be subject to change as plants further analyze their capabilities, even in the near-term. The results of this assessment indicate that 48% of the selected plants have rail access and 59% are judged to be candidates for overweight truck shipments (with 8 unknowns due to unavailability of verifiable data). Essentially all of the reactors can accommodate existing legal-weight truck casks. 12 references, 1 figure, 4 tables

  6. Advances in National Capabilities for Consequence Assessment Modeling of Airborne Hazards

    Energy Technology Data Exchange (ETDEWEB)

    Nasstrom, J; Sugiyama, G; Foster, K; Larsen, S; Kosovic, B; Eme, B; Walker, H; Goldstein, P; Lundquist, J; Pobanz, B; Fulton, J

    2007-11-26

    This paper describes ongoing advancement of airborne hazard modeling capabilities in support of multiple agencies through the National Atmospheric Release Advisory Center (NARAC) and the Interagency Atmospheric Modeling and Atmospheric Assessment Center (IMAAC). A suite of software tools developed by Lawrence Livermore National Laboratory (LLNL) and collaborating organizations includes simple stand-alone, local-scale plume modeling tools for end user's computers, Web- and Internet-based software to access advanced 3-D flow and atmospheric dispersion modeling tools and expert analysis from the national center at LLNL, and state-of-the-science high-resolution urban models and event reconstruction capabilities.

  7. Process for Upgrading Cognitive Assessment Capabilities Onboard the International Space Station

    Science.gov (United States)

    Picano, J. J.; Seaton, K. A.; Holland, A. W.

    2016-01-01

    MOTIVATION: Spaceflight poses varied and unique risks to the brain and cognitive functioning including radiation exposure, sleep disturbance, fatigue, fluid shifts (increased intracranial pressure), toxin exposure, elevated carbon dioxide, and traumatic brain injury, among others. These potential threats to cognitive functioning are capable of degrading performance and compromising mission success. Furthermore, the threats may increase in severity, and new types of threats may emerge for longer duration exploration missions. This presentation will describe the process used to identify gaps in our current approach, evaluate best practices in cognitive assessment, and transition new cognitive assessment tools to operational use. OVERVIEW: Risks to brain health and performance posed by spaceflight missions require sensitive tools to assess cognitive functioning of astronauts in flight. The Spaceflight Cognitive Assessment Tool for Windows (WinSCAT) is the automated cognitive assessment tool currently deployed onboard the International Space Station (ISS). WinSCAT provides astronauts and flight surgeons with objective data to monitor neurocognitive functioning. WinSCAT assesses 5 discrete cognitive domains, is sensitive to changes in cognitive functioning, and was designed to be completed in less than 15 minutes. However, WinSCAT does not probe other areas of cognitive functioning that might be important to mission success. Researchers recently have developed batteries that may expand current capabilities, such as increased sensitivity to subtle fluctuations in cognitive functioning. Therefore, we engaged in a systematic process review in order to improve upon our current capabilities and incorporate new advances in cognitive assessment. This process included a literature review on newer measures of neurocognitive assessment, surveys of operational flight surgeons at NASA regarding needs and gaps in our capabilities, and expert panel review of candidate cognitive

  8. AN ASSESSMENT FOR SUSTAINABLE DEVELOPING CAPABILITY OF INTEGRATED AGRICULTURAL REGIONALIZATION IN CHINA

    Institute of Scientific and Technical Information of China (English)

    XUXue-gong; LINHui-ping; 等

    2002-01-01

    Based on the provincial units evaluation,this paper makes an assessment for sustainable developing capability of the integrated agricultural regionalization in China.At first ,an index system of agricultural sustainable development in China is built up,which includes 5 supporting subsystems of agricultural resources,agricultural develop-ment ,environment and ecosystem,rural society,sciences-esucation and management.We selected 95 factors on provin-cial level as basic indexes.Second,a relative assets/debt assessing method is used to gain relative net assets values (relative superiority) of every provincial unit,which are as supporting data for assessment.We also overlaid the Administra-tive Divisions Map of China and the Map of Integrated Agricultural Regionalization of China by Geography Information Sys-tem(GIS) to gain the area units of assessment.Third,according to the relative coherence principle of regionalization,we transform administration units to natural units through homogenizing all provincial relative net assets values in every agricultural assessing unit.After making order and grade,we complete the sustainable developing capability assessment to integrated agricultural regionalization in China.The assessing outcome shows that the total sustainable agricultural devdelop-ing capability of China is not high.Only about 1/3 in number or in area has reached the level of agricultural sustainable development.The relative net assets values exists a reducing trend from East China to West China.It needs a long period and great efforts to realize sustainable agricultural development over all China.Finally,there is a discussion to the study method.

  9. AN ASSESSMENT FOR SUSTAINABLE DEVELOPING CAPABILITY OF INTEGRATED AGRICULTURAL REGIONALIZATION IN CHINA

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Based on the provincial units evaluation, this paper makes an assessment for sustainable developingcapability of the integrated agricultural regionalization in China. At first, an index system of agricultural sustainabledevelopment in China is built up, which includes 5 supporting subsystems of agricultural resources, agricultural develop-ment, environment and ecosystem, rural society, sciences-education and management. We selected 95 factors on provin-cial level as basic indexes. Second, a relative assets/debt assessing method is used to gain relative net assets values(relative superiority) of every provincial unit, which are as supporting data for assessment. We also overlaid the Administra-tive Divisions Map of China and the Map of Integrated Agricultural Regionalization of China by Geography Information Sys-tem (GIS) to gain the area units of assessment. Third, according to the relative coherence principle of regionalization,we transform administration units to natural units through homogenizing all provincial relative net assets values in everyagricultural assessing unit. After making order and grade, we complete the sustainable developing capability assessmentto integrated agricultural regionalization in China. The assessing outcome shows that the total sustainable agricultural develop-ing capability of China is not high. Only about 1/3 in number or in area has reached the level of agricultural sustainabledevelopment. The relative net assets values exists a reducing trend from East China to West China. It needs a long periodand great efforts to realize sustainable agricultural development over all China. Finally, there is a discussion to the studymethod.

  10. Small Satellite Verification and Assessment Test Facility with Space Environments Effects Ground-testing Capabilities

    OpenAIRE

    Stromberg, Eric; Frazier, Crystal; Montierth Phillipps, Lisa; Souvall, Alex; Dennison, JR; Dyer, James S.

    2015-01-01

    The Utah State University Space Dynamics Laboratory (SDL) and Materials Physics Group (MPG) have developed an extensive versatile and cost-effective pre-launch test capability for verification and assessment of small satellites, system components, and spacecraft materials. The facilities can perform environmental testing, component characterization, system level hardware in-the-loop testing, and qualification testing to ensure that each element is functional, reliable, and working per its des...

  11. Assessment of the ONERA/DLR numerical aeroelastics prediction capabilities on the HIRENASD configuration

    OpenAIRE

    Hassan, D.; Ritter, Markus

    2011-01-01

    The present paper deals with steady and unsteady aeroelastic simulation results obtained on the High Reynolds Number Aero-Structural Dynamics (HIRENASD) wind tunnel configuration [1], selected as common test case in the numerical aeroelasticity ONERA/DLR cooperation project “NLAS2”. In order to assess the aeroelastic prediction capabilities of the flow solvers elsA (ONERA) and TAU (DLR), 3 types of simulations have been realized: static coupling, harmonic forced motion and dynamic coupling...

  12. A Process for Assessing NASA's Capability in Aircraft Noise Prediction Technology

    Science.gov (United States)

    Dahl, Milo D.

    2008-01-01

    An acoustic assessment is being conducted by NASA that has been designed to assess the current state of the art in NASA s capability to predict aircraft related noise and to establish baselines for gauging future progress in the field. The process for determining NASA s current capabilities includes quantifying the differences between noise predictions and measurements of noise from experimental tests. The computed noise predictions are being obtained from semi-empirical, analytical, statistical, and numerical codes. In addition, errors and uncertainties are being identified and quantified both in the predictions and in the measured data to further enhance the credibility of the assessment. The content of this paper contains preliminary results, since the assessment project has not been fully completed, based on the contributions of many researchers and shows a select sample of the types of results obtained regarding the prediction of aircraft noise at both the system and component levels. The system level results are for engines and aircraft. The component level results are for fan broadband noise, for jet noise from a variety of nozzles, and for airframe noise from flaps and landing gear parts. There are also sample results for sound attenuation in lined ducts with flow and the behavior of acoustic lining in ducts.

  13. Assessing the Capability of Code Smells to Support Software Maintainability Assessments : Empirical Inquiry and Methodological Approach

    OpenAIRE

    2012-01-01

    Code smells are indicators of software design shortcomings that can decrease software maintainability. An advantage of code smells over traditional software measures is that the former are associated with an explicit set of refactoring strategies to improve the existing design. As such, code smell analysis is a promising approach to address both the assessment and the improvement of maintainability. An important challenge in code smell analysis is understanding the interplay between code smel...

  14. Assessment of databases and modeling capabilities for the CANDU 3 design

    International Nuclear Information System (INIS)

    The NRC staff has been conducting a preliminary review of the CANDU 3 (Canadian Deuterium Uranium Model 3) reactor design, a new heavy-water design developed by Atomic Energy of Canada Limited through its US affiliate, AECL Technologies. The review has been aimed at identifying key technical areas and policy issues that will have to be addressed for standard design certification. As part of the research program associated with the preliminary review, the NRC Office of Nuclear Regulatory Research (RES) has completed an assessment of databases and modeling capabilities that might be needed to support the CANDU 3 design. To ensure full coverage of the design, a detailed assessment methodology was developed by the RES staff and was implemented with help from research projects at three national laboratories. This report integrates and summarizes the database and modeling assessments, including major contributions from these laboratories. 395 refs

  15. Reliability Analysis and Overload Capability Assessment of Oil-Immersed Power Transformers

    Directory of Open Access Journals (Sweden)

    Chen Wang

    2016-01-01

    Full Text Available Smart grids have been constructed so as to guarantee the security and stability of the power grid in recent years. Power transformers are a most vital component in the complicated smart grid network. Any transformer failure can cause damage of the whole power system, within which the failures caused by overloading cannot be ignored. This research gives a new insight into overload capability assessment of transformers. The hot-spot temperature of the winding is the most critical factor in measuring the overload capacity of power transformers. Thus, the hot-spot temperature is calculated to obtain the duration running time of the power transformers under overloading conditions. Then the overloading probability is fitted with the mature and widely accepted Weibull probability density function. To guarantee the accuracy of this fitting, a new objective function is proposed to obtain the desired parameters in the Weibull distributions. In addition, ten different mutation scenarios are adopted in the differential evolutionary algorithm to optimize the parameter in the Weibull distribution. The final comprehensive overload capability of the power transformer is assessed by the duration running time as well as the overloading probability. Compared with the previous studies that take no account of the overloading probability, the assessment results obtained in this research are much more reliable.

  16. A New Systematic Approach to Vulnerability Assessment of Innovation Capability of Construction Enterprises

    Directory of Open Access Journals (Sweden)

    Jingxiao Zhang

    2015-12-01

    Full Text Available The purpose of this research is to study the vulnerability of construction enterprises’ innovation capabilities (CEIC and their respective primary influencing factors. This paper proposed a vulnerability system framework of CEIC, designed two comprehensive assessments for analysis, namely the entropy and set pair analysis method (E-SPA and the principle cluster analysis and SPA method (P-SPA, and compared grades to verify the vulnerability assessments. Further, the paper quantitatively assessed the major influencing factors in facilitating management, reducing vulnerability, and improving the ability of construction enterprises to respond to changes in the construction industry. The results showed that vulnerability could be effectively and systematically evaluated using E-SPA. However, managing or reducing entrepreneurial sensitivity and improving the ability to respond was critical to supporting sustainable CEIC. The case studies included in this paper suggested that in ensuring sustainable CEIC, companies should concentrate on highly educated human resources, R&D investments, intellectual property related innovations, and government support. This research provided a practical framework and established a sustainable strategy for companies to manage their vulnerability in developing innovation capability. In addition, this research presented an innovative and effective way to quantitatively analyze vulnerability which offered a foundation to signify a new paradigm shift in construction sustainable development.

  17. Capability and quality assessment of rice growing hydric soils in majuli river island, assam, India

    Directory of Open Access Journals (Sweden)

    Bhaskara Phaneendra Bhaskar

    2013-06-01

    Full Text Available The  wetland soils in  majuli island is a unique in maintaining rice ecology and geoenvironment in Brahmaputra valley of Assam  due to increasing  rate of  bankline erosion in southern bank  and expansion of channel bars on northern banks. These hydric soils in the subgroups of aquents and aquepts are  saturated throughout year as assessed from depleted matrix with hue 10YR, 2.5Y and 5Y, chroma less than 2, stratified textures, neutral to slightly alkaline reaction, low cation exchange capacity  and poor exchangeable base status. The  assessment of land capability and soil quality  for rice production in   hydric soils  was conducted on twenty four soil mapping units derived from reconnaissance soil survey done on 1:50000 scale.  As per  land capability  assessment, these soils are  good(classII to fairly good(IV for arable use with limitations of low fertility status, moderate to severe wetness and moderate to rapid permeability. The soil quality rating with  multiple variable indicator transform(MVIT technique  of  twenty hydric soil units in active and old floodplains was  medium (35 to 65per cent with six indicators(pH, organic carbon, base saturation, effective rooting depth , structure and texture meeting the thresh hold value  above 65 per cent.  Thirty five  per cent of total area is suitable for rice cultivation as against the current cropped area of 7.2 per cent with potassium and zinc deficiency. The determination of soil quality in relation to land capability was found useful to design best management practices for wetlands in the region that ensure sustainable land use.

  18. Component-Level Electronic-Assembly Repair (CLEAR) Synthetic Instrument Capabilities Assessment and Test Report

    Science.gov (United States)

    Oeftering, Richard C.; Bradish, Martin A.

    2011-01-01

    The role of synthetic instruments (SIs) for Component-Level Electronic-Assembly Repair (CLEAR) is to provide an external lower-level diagnostic and functional test capability beyond the built-in-test capabilities of spacecraft electronics. Built-in diagnostics can report faults and symptoms, but isolating the root cause and performing corrective action requires specialized instruments. Often a fault can be revealed by emulating the operation of external hardware. This implies complex hardware that is too massive to be accommodated in spacecraft. The SI strategy is aimed at minimizing complexity and mass by employing highly reconfigurable instruments that perform diagnostics and emulate external functions. In effect, SI can synthesize an instrument on demand. The SI architecture section of this document summarizes the result of a recent program diagnostic and test needs assessment based on the International Space Station. The SI architecture addresses operational issues such as minimizing crew time and crew skill level, and the SI data transactions between the crew and supporting ground engineering searching for the root cause and formulating corrective actions. SI technology is described within a teleoperations framework. The remaining sections describe a lab demonstration intended to show that a single SI circuit could synthesize an instrument in hardware and subsequently clear the hardware and synthesize a completely different instrument on demand. An analysis of the capabilities and limitations of commercially available SI hardware and programming tools is included. Future work in SI technology is also described.

  19. Developing the P2/6 methodology [to assess the security capability of modern distributed generation

    Energy Technology Data Exchange (ETDEWEB)

    Allan, Ron; Strbac, Goran; Djapic, Predrag; Jarrett, Keith [Manchester Univ. Inst. of Science and Technology, Manchester (United Kingdom)

    2004-04-29

    The main objective of the project was to use the methodology developed in the previous Methodology project (ETSU/FES Project K/EL/00287) to assess the security capability of modern distributed generation in order to review Table 2 and related text of Engineering Recommendation P2/5, and to propose information and results that could be used to create a new P2/6 that takes into account modern types of generating units; unit numbers; unit availabilities; and capacities. Technical issues raised in the previous study but held over until this project include: Treatment of single unit generation systems; Effect of shape of load duration curves; Persistence of intermittent generation, T{sub m}; Time resolution of intermittent generation output profiles; Ride-through capability; Risk to loss of supply. Three main ways of implementing the methodology were recommended: Look-up table(s), Graphical, and Computer program. The specification for the computer program was to produce a simple spreadsheet application package that an engineer with a reasonably knowledge of the approach could use. This prototype package has been developed in conjunction with Workstream 3. Its objective is to calculate the capability contribution to security of supply from distributed generation connected to a particular demand group. The application has been developed using Microsoft Excel and Visual Basic for Applications. New Tables for inclusion in P2/6 are included. (UK)

  20. Assessment of U.S. Manufacturing Capability for Next-Generation Wind Turbine Drivetrains

    Energy Technology Data Exchange (ETDEWEB)

    Cotrell, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stelhy, T. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-09-01

    Robust U.S. wind turbine manufacturing capabilities and supply chains are important for the United States to reduce the cost of electricity generated from wind turbines. These capabilities and supply chains are also critical to the invention and commercialization of new wind turbine technologies while providing high-quality jobs. The development of advanced drivetrain technologies for windturbine applications is advancing the state of the art for drivetrain design by producing higher capacity and operating reliability than conventional drivetrains. Advanced drivetrain technologies such as medium-speed and direct-drive generators, silicon-carbide (SiC) IGBT-based power electronics, and high torque density speed increasers require different manufacturing and supply chaincapabilities that present both risks and opportunities for U.S. wind turbine manufacturers and the wind industry as a whole. The primary objective of this project is to assess how advanced drivetrain technologies and trends will impact U.S. wind turbine manufacturing and its supply chains. The U.S. Department of Energy and other industry participants will use the information from this study toidentify domestic manufacturing gaps, barriers, and opportunities for developing U.S. wind turbine manufacturing capabilities and supply chains for next-generation drivetrain technologies. This report also includes recommendations for prioritizing technology areas for possible investments by public, private, or nonprofit entities that will reduce the cost of wind-generated electricity. Suchinvestments foster opportunities to invent and commercialize new wind turbine technologies, and provide high-quality jobs in the United States.

  1. All-data approach to assessing financial capability in people with psychiatric disabilities.

    Science.gov (United States)

    Lazar, Christina M; Black, Anne C; McMahon, Thomas J; Rosenheck, Robert A; Ries, Richard; Ames, Donna; Rosen, Marc I

    2016-04-01

    The goal of this project was to develop an evidence-based method to assess the ability of disabled persons to manage federal disability payments. This article describes the development of the Financial Incapability Structured Clinical Assessment done Longitudinally (FISCAL) measure of financial capability. The FISCAL was developed by an iterative process of literature review, pilot testing, and expert consultation. Independent assessors used the FISCAL to rate the financial capability of 118 participants (57% female, 58% Caucasian) who received Social Security disability payments, had recently been treated in acute care facilities for psychiatric disorders, and who did not have representative payees or conservators. Altogether, 48% of participants were determined financially incapable by the FISCAL, of whom 60% were incapable because of unmet basic needs, 91% were incapable because of spending that harmed them (e.g., on illicit drugs or alcohol), 56% were incapable because of both unmet needs and harmful spending, and 5% were incapable because of contextual factors. As expected, incapable individuals scored higher on a measure of money mismanagement (p manage their funds. PMID:26146947

  2. Total Transfer Capability Assessment Incorporating Corrective Controls for Transient Stability using TSCOPF

    Science.gov (United States)

    Hakim, Lukmanul; Kubokawa, Junji; Yorino, Naoto; Zoka, Yoshifumi; Sasaki, Yutaka

    Advancements have been made towards inclusion of both static and dynamic security into transfer capability calculation. However, to the authors' knowledge, work on considering corrective controls into the calculation has not been reported yet. Therefore, we propose a Total Transfer Capability (TTC) assessment considering transient stability corrective controls. The method is based on the Newton interior point method for nonlinear programming and transfer capability is approached as a maximization of power transfer with both static and transient stability constraints are incorporated into our Transient Stability Constrained Optimal Power Flow (TSCOPF) formulation. An interconnected power system is simulated to be subjected to a severe unbalanced 3-phase 4-line to ground fault and following the fault, generator and load are shed in a pre-defined sequence to mimic actual corrective controls. In a deregulated electricity market, both generator companies and large load customers are encouraged to actively participate in maintaining power system stability as corrective controls upon agreement of compensation for being shed following a disturbance. Implementation of this proposal on the actual power system operation should be carried out through combining it with the existing transient stabilization controller system. Utilization of these corrective controls results in increasing TTC as suggested in our numerical simulation. As Lagrange multipliers can also describe sensitivity of both inequality and equality constraints to the objective function, then selection of which generator or load to be shed can be carried out on the basis of values of Lagrange multipliers of its respective generator's rotor angle stability and active power balance equation. Hence, the proposal in this paper can be utilized by system operator to assess the maximum TTC for specific loads and network conditions.

  3. Analysis of the virulence-associated RevSR two-component signal transduction system of Clostridium perfringens.

    Science.gov (United States)

    Cheung, Jackie K; Wisniewski, Jessica A; Adams, Vicki M; Quinsey, Noelene S; Rood, Julian I

    2016-09-01

    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that causes human gas gangrene (clostridial myonecrosis) and food poisoning. Early studies showed that virulence was regulated by the VirSR two-component signal transduction system. However, our identification of the RevR orphan response regulator indicated that more than one system was involved in controlling virulence. To further characterize this virulence-associated regulator, gel mobility shift experiments, coupled with DNase I footprinting, were used to identify the RevR DNA binding sequence. Bioinformatics analysis suggested that an orphan sensor histidine kinase, CPE1757 (renamed RevS), was the cognate sensor of RevR. Interaction between RevS and RevR was demonstrated by use of a bacterial two-hybrid system and validated by protein-protein interaction studies using biolayer interferometry. To assess the involvement of RevS in virulence regulation, the revS gene was inactivated by Targetron insertion. When isogenic wild-type, revS and complemented revS strains were tested in a mouse myonecrosis model, the revS mutant was found to be attenuated in virulence, which was similar to the attenuation observed previously with the revR mutant. However, transcriptional analysis of selected RevR-regulated genes in the revS mutant revealed a different pattern of expression to a revR mutant, suggesting that the RevSR system is more complex than originally thought. Taken together, the results have led to the identification and characterization of the two essential parts of a new regulatory network that is involved in the regulation of virulence in C. perfringens.

  4. Development of Modern Performance Assessment Tools and Capabilities for Underground Disposal of Transuranic Waste at WIPP

    Science.gov (United States)

    Zeitler, T.; Kirchner, T. B.; Hammond, G. E.; Park, H.

    2014-12-01

    The Waste Isolation Pilot Plant (WIPP) has been developed by the U.S. Department of Energy (DOE) for the geologic (deep underground) disposal of transuranic (TRU) waste. Containment of TRU waste at the WIPP is regulated by the U.S. Environmental Protection Agency (EPA). The DOE demonstrates compliance with the containment requirements by means of performance assessment (PA) calculations. WIPP PA calculations estimate the probability and consequence of potential radionuclide releases from the repository to the accessible environment for a regulatory period of 10,000 years after facility closure. The long-term performance of the repository is assessed using a suite of sophisticated computational codes. In a broad modernization effort, the DOE has overseen the transfer of these codes to modern hardware and software platforms. Additionally, there is a current effort to establish new performance assessment capabilities through the further development of the PFLOTRAN software, a state-of-the-art massively parallel subsurface flow and reactive transport code. Improvements to the current computational environment will result in greater detail in the final models due to the parallelization afforded by the modern code. Parallelization will allow for relatively faster calculations, as well as a move from a two-dimensional calculation grid to a three-dimensional grid. The result of the modernization effort will be a state-of-the-art subsurface flow and transport capability that will serve WIPP PA into the future. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. This research is funded by WIPP programs administered by the Office of Environmental Management (EM) of the U.S Department of Energy.

  5. Assessing COSMO-SkyMed capability for crops identification and monitoring

    Science.gov (United States)

    Guarini, R.; Dini, L.

    2015-12-01

    In the last decade, it has been possible to better understand the impact of agricultural human practices on the global environmental change at different spatial (from local to global) and time (from seasonal to decadal) scales. This has been achieved thanks to: big dataset continuously acquired by Earth Observation (EO) satellites; the improved capabilities of remote sensing techniques in extracting valuable information from the EO datasets; the new EO data policy which allowed unrestricted data usage; the net technologies which allowed to quickly and easily share national, international and market-derived information; an increasingly performing computing technology which allows to massively process large amount of data easier and at decreasing costs. To better understand the environmental impacts of agriculture and to monitor the consequences of human agricultural activities on the biosphere, scientists require to better identify crops and monitor crop conditions over time and space. Traditionally, NDVI time series maps derived from optical sensors have been used to this aim. As well-known this important source of information is conditioned by cloud cover. Unlike passive systems, synthetic aperture radar (SAR) ones are almost insensitive to atmospheric influences; thus, they are especially suitable for crop identification and condition monitoring. Among the other SAR systems currently in orbit, the Italian Space Agency (ASI) COSMO Sky-Med® (CSK®) constellation (X-band, frequency 9.6 GHz, wavelength 3.1 cm), especially for its peculiar high revisit capability (up to four images in 16 days with same acquisition geometry) seems to be particular suitable for providing information in addition and/or in alternative to other optical EO systems. To assess the capability of the CSK® constellation in identifying crops and in monitoring crops condition in 2013 ASI started the "AGRICIDOT" project. Some of the main project achievements will be presented at the congress.

  6. Comparative Assessment and Decision Support System for Strategic Military Airlift Capability

    Science.gov (United States)

    Salmon, John; Iwata, Curtis; Mavris, Dimitri; Weston, Neil; Fahringer, Philip

    2011-01-01

    The Lockheed Martin Aeronautics Company has been awarded several programs to modernize the aging C-5 military transport fleet. In order to ensure its continuation amidst budget cuts, it was important to engage the decision makers by providing an environment to analyze the benefits of the modernization program. This paper describes an interface that allows the user to change inputs such as the scenario airfields, take-off conditions, and reliability characteristics. The underlying logistics surrogate model was generated using data from a discrete-event simulation. Various visualizations such as intercontinental flight paths illustrated in 3D, have been created to aid the user in analyzing scenarios and performing comparative assessments for various output logistics metrics. The capability to rapidly and dynamically evaluate and compare scenarios was developed enabling real time strategy exploration and trade-offs.

  7. Development, qualification and use of a code with the capability of internal assessment of uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Petruzzi, A. [Pennsylvania State Univ., Dept. of Mechanical and Nuclear Engineering, University Park, Pennsylvania (United States)]|[Univ. of Pisa, Dipartimento di Ingegneria Meccanica, Nucleare e della Produzione, Pisa (Italy)]. E-mail: axp46@psu.edu; Giannotti, W.; D' Auria, F. [Univ. of Pisa, Dipartimento di Ingegneria Meccanica, Nucleare e della Produzione, Pisa (Italy)]. E-mail: w.giannotti@ing.unipi.it; dauria@ing.unipi.it; Ivanov, K. [Pennsylvania State Univ., Dept. of Mechanical and Nuclear Engineering, University Park, Pennsylvania (United States)]. E-mail: knil@psu.edu

    2004-07-01

    The best-estimate calculation results from complex system codes are affected by approximations that are un-predictable without the use of computational tools that account for the various sources of uncertainty. The Code with (the capability of) Internal Assessment of Uncertainty (CIAU) has been proposed by the University of Pisa to realize the integration between a qualified best-estimate thermal-hydraulic system code and a suitable uncertainty methodology and to supply proper uncertainty bands each time a nuclear power plant transient scenario is calculated. In the frame of a cooperation with The Pennsylvania State University, the CIAU code has been recently extended to evaluate the uncertainty of coupled 3-D neutronics/thermal-hydraulics calculations. The result of this effort is CIAU-TN. The derivation of the methodology and the adopted qualification processes ('internal' and 'external') are described in the paper. (author)

  8. Lawrence Livermore National Laboratory Emergency Response Capability Baseline Needs Assessment Requirement Document

    Energy Technology Data Exchange (ETDEWEB)

    Sharry, J A

    2009-12-30

    This revision of the LLNL Fire Protection Baseline Needs Assessment (BNA) was prepared by John A. Sharry, LLNL Fire Marshal and LLNL Division Leader for Fire Protection and reviewed by Martin Gresho, Sandia/CA Fire Marshal. The document follows and expands upon the format and contents of the DOE Model Fire Protection Baseline Capabilities Assessment document contained on the DOE Fire Protection Web Site, but only address emergency response. The original LLNL BNA was created on April 23, 1997 as a means of collecting all requirements concerning emergency response capabilities at LLNL (including response to emergencies at Sandia/CA) into one BNA document. The original BNA documented the basis for emergency response, emergency personnel staffing, and emergency response equipment over the years. The BNA has been updated and reissued five times since in 1998, 1999, 2000, 2002, and 2004. A significant format change was performed in the 2004 update of the BNA in that it was 'zero based.' Starting with the requirement documents, the 2004 BNA evaluated the requirements, and determined minimum needs without regard to previous evaluations. This 2010 update maintains the same basic format and requirements as the 2004 BNA. In this 2010 BNA, as in the previous BNA, the document has been intentionally divided into two separate documents - the needs assessment (1) and the compliance assessment (2). The needs assessment will be referred to as the BNA and the compliance assessment will be referred to as the BNA Compliance Assessment. The primary driver for separation is that the needs assessment identifies the detailed applicable regulations (primarily NFPA Standards) for emergency response capabilities based on the hazards present at LLNL and Sandia/CA and the geographical location of the facilities. The needs assessment also identifies areas where the modification of the requirements in the applicable NFPA standards is appropriate, due to the improved fire protection

  9. Assessment of Radiated Fan Noise Prediction Capabilities Using Static Engine Test Data

    Science.gov (United States)

    Nark, Douglas M.

    2011-01-01

    This paper describes further assessment of the CDUCT-LaRC code via comparison with static engine test data. In an effort to improve confidence in the use of CDUCT-LaRC for liner optimization studies addressing realistic three-dimensional geometries, inlet radiated fan noise predictions were performed at 54% and 87% engine speed settings. Predictions were then compared with far-field measurements to assess the approach and implementation. The particular configurations were chosen to exercise the three-dimensional capability of CDUCT-LaRC and it s applicability to realistic configurations and conditions. At the 54% engine speed setting, the predictions capture the general directivity and acoustic treatment effects quite well. Comparisons of the predicted and measured directivity at the 87% power setting were more problematic. This was likely due in part to the difficulties in source specification and possibly the nonlinear nature of buzz-saw tones at this engine operating condition. Overall, the approach captured the basic trends and provided a conservative estimate of liner effects from which relative performance metrics could be inferred.

  10. An Assessment of ORNL PIE Capabilities for the AGR Program Capsule Post Irradiation Examination

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Robert Noel [ORNL

    2006-09-01

    ORNL has facilities and experienced staff that can execute +the Advanced Gas Reactor (AGR) Post Irradiation Examination (PIE) task. While the specific PIE breakdown needs to be more formally defined, the basic outline is clear and the existing capabilities can be assessed within the needs of the tasks defined in the program plan. A one-to-one correspondence between the program plan tasks and the current ORNL PIE status was conducted and while some shortcomings were identified, the general capability is available. Specific upgrade needs were identified and reviewed. A path forward was formulated. Building 3525 is available for this work and this building is currently receiving renewed attention from management so that it will be in good working order prior to the expected PIE start date. This building is equipped with the tools necessary for PIEs of this nature, but the long hiatus in coated particle fuel work has left it with aging analysis tools. This report identified several of these tools and rough estimates of what would be required to update and replace them. In addition, other ORNL buildings are available to support Building 3525 in specialized tasks along with the normal laboratory infrastructure. Before the AGR management embarks on any equipment development effort, the PIE tasks should be updated against current program (modeling and data) needs and better defined so that the items to be measured, their measurement uncertainties, and thru-put needs can be reviewed. A Data Task Matrix (DTM) should be prepared so that the program data needs can be compared against the identified PIE tasks and what is practical in the hot cell environment to make sure nothing is overlooked. Finally, thought should be given to the development of standardized equipment designs between sites to avoid redundant design efforts and different measurement techniques. This is a potentially cost saving effort that can also avoid data inconsistencies.

  11. ENVIRONMENTAL ASSESSMENT OF BARRIER CAPABILITIES OF SMALL MUNICIPAL WASTEWATER TREATMENT PLANTS IN VOLOGDA REGION

    Directory of Open Access Journals (Sweden)

    Kulakov Artem Alekseevich

    2012-12-01

    Full Text Available The findings of the research project that encompasses 137 small municipal wastewater treatment plants (WWTP are presented in the paper. The source data for the research is the official statistical reporting according to Form № 2-TP (water submitted in 2010, as well as the information on completed and approved projects that demonstrate admissible discharge standards. The method of environmental assessment of barrier capabilities of municipal WWTP based on six major indicators (TSS, BOD, N-NH4+, N-NO2-, N-NO3-, P-PO43- is proposed to ensure compliance with the present-day environmental standards. The maximal likelihood of incompliance with the pre-set standards is demonstrated by phosphorus phosphate (97 %, ammonium nitrogen (95 % and nitrite nitrogen (79 %. The substances that demonstrate their maximal excessive content in the wastewater include phosphorus phosphate (its content exceeds the admissible standard 18-fold, ammonium nitrogen (21.7-fold excess and nitrite nitrogen (7.6-fold excess.This overview indicates a low possibility of compliance of the content of N-NH4+, N-NO2-, and P-PO43- with the environmental standards that extend to biological WWTPs. The highest relative excess of the admissible content of admixtures is typical for the plants that have a design capacity of 600-800 m3/day and that process 50-200 m3/day. The lowest relative excess of the admissible content of admixtures is typical for the plants that have a design capacity of over 1,000 m3/day and that process over 500 m3/day. The average relative excess of the admissible content of admixtures for all plants equals to 8.4 times. The ecological assessment of the barrier capabilities of small municipal WWTPs has proven that their compliance with the standards of admissible content of N-NH4+, N-NO2-, and P-PO43- in the wastewater is impossible to attain in practice.

  12. Introduction to the Biomass Project: An Illustration of Evidence-Centered Assessment Design and Delivery Capability. CSE Report.

    Science.gov (United States)

    Steinberg, Linda S.; Mislevy, Robert J.; Almond, Russell G.; Baird, Andrew B.; Cahallan, Cara; Dibello, Louis V.; Senturk, Deniz; Yan, Duanli; Chernick, Howard; Kindfield, Ann C. H.

    This paper describes the design rationale for a prototype of an innovative assessment product, and the process that led to the design. The goals of the Biomass project were to demonstrate: (1) an assessment product designed to serve two new purposes in the transition from high school to college; and (2) the capability needed to produce this kind…

  13. Assessment of Prediction Capabilities of COCOSYS and CFX Code for Simplified Containment

    Directory of Open Access Journals (Sweden)

    Jia Zhu

    2016-01-01

    Full Text Available The acceptable accuracy for simulation of severe accident scenarios in containments of nuclear power plants is required to investigate the consequences of severe accidents and effectiveness of potential counter measures. For this purpose, the actual capability of CFX tool and COCOSYS code is assessed in prototypical geometries for simplified physical process-plume (due to a heat source under adiabatic and convection boundary condition, respectively. Results of the comparison under adiabatic boundary condition show that good agreement is obtained among the analytical solution, COCOSYS prediction, and CFX prediction for zone temperature. The general trend of the temperature distribution along the vertical direction predicted by COCOSYS agrees with the CFX prediction except in dome, and this phenomenon is predicted well by CFX and failed to be reproduced by COCOSYS. Both COCOSYS and CFX indicate that there is no temperature stratification inside dome. CFX prediction shows that temperature stratification area occurs beneath the dome and away from the heat source. Temperature stratification area under adiabatic boundary condition is bigger than that under convection boundary condition. The results indicate that the average temperature inside containment predicted with COCOSYS model is overestimated under adiabatic boundary condition, while it is underestimated under convection boundary condition compared to CFX prediction.

  14. Capabilities to Assess Health/Maintenance Status of Gas Turbine Blades with Non-Destructive Methods

    Directory of Open Access Journals (Sweden)

    Błachnio Józef

    2015-01-01

    Full Text Available The paper has been intended to discuss non-destructive testing methods and to present capabilities of applying them to diagnose objectively changes in the microstructure of a turbine blade with computer software engaged to assist with the analyses. The following techniques are discussed: a visual method, based on the processing of images of the material surface in visible light, active thermography, based on the detection of infrared radiation, and the X-ray computed tomography. All these are new non-destructive methods of assessing technical condition of structural components of machines. They have been intensively developed at research centers worldwide, and in Poland. The computer-aided visual method of analyzing images enables diagnosis of the condition of turbine blades, without the necessity of dismantling of the turbine. On the other hand, the active thermography and the X-ray computed tomography, although more sensitive and more reliable, can both be used with the blades dismounted from the turbine. If applied in a complex way, the non-destructive methods presented in this paper, are expected to increase significantly probability of detecting changes in the blade's condition, which in turn would be advantageous to reliability and safety of gas turbine service.

  15. Environmental assessment and planning at Mound - environmental monitoring capabilities and personnel profiles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    Through its long experience with radioactive materials, Mound has developed a comprehensive, routine, offsite, environmental surveillance program to safeguard its employees, the physical plant, and the integrity of the surrounding environment from any potential adverse effects of its widely diverse operations. Effluent samples are analyzed for radiological and non-radiological parameters. The environment surrounding Mound Facility is continuously monitored - air, water, foodstuffs, vegetation, soil, and silt samples are analyzed to ensure that radioisotopic concentrations and other possible pollutants are well within the stringent standards adopted by the Department of Energy, the Environmental Protection Agencies (both federal and state), and various regional and local agencies. Moreover, this environmental surveillance program has been designed to ensure that the facility is designed, constructed, managed, operated, and maintained in a manner that continues to meet all federal, state, and local standards for environmental protection. Work in environmental science has been broadened to assess environmental factors associated with various aspects of the National Energy Plan. Both the management and staff at Mound have undertaken a firm commitment to make Mound`s environmental monitoring capabilities available to agencies that have the responsibility for the resolution of important environmental issues.

  16. Integrating measuring uncertainty of tactile and optical coordinate measuring machines in the process capability assessment of micro injection moulding

    DEFF Research Database (Denmark)

    Tosello, Guido; Hansen, Hans Nørgaard; Gasparin, Stefania

    2010-01-01

    Process capability of micro injection moulding was investigated in this paper by calculating the Cp and Cpk statistics. Uncertainty of both optical and tactile measuring systems employed in the quality control of micro injection moulded products was assessed and compared with the specified...... tolerances. Limits in terms of manufacturing process capability as well as of suitability of such measuring systems when employed for micro production inspection were quantitatively determined....

  17. Assessing Risk Management Capability of Public Sector Organizations Related to PPP Scheme Development for Water Supply in Indonesia

    OpenAIRE

    Pangeran M.H.; Notodarmojo S.; Wirahadikusumah R.D.; Pribadi K.S.

    2012-01-01

    The success of Public Private Partnership (PPP) for water supply investment is inseparable from the capability of risk management of the parties within the project. This study investigates the risk management capability of Indonesian local public sector organizations that are potentially involved in PPP schemes for water supply. A risk management maturity model based assessment tool probing the culture, process, experience, application and partnership aspects is used in the survey. The model ...

  18. Earth Observations and the Role of UAVs: A Capabilities Assessment. Version 1.1

    Science.gov (United States)

    Cox, Timothy H.; Somers, Ivan; Fratello, David J.

    2006-01-01

    This document provides an assessment of the civil UAV missions and technologies and is intended to parallel the Office of the Secretary of Defense UAV Roadmap. The intent of this document is four-fold: 1. Determine and document desired future missions of Earth observation UAVs based on user-defined needs 2. Determine and document the technologies necessary to support those missions 3. Discuss the present state of the platform capabilities and required technologies, identifying those in progress, those planned, and those for which no current plans exist 4. Provide the foundations for development of a comprehensive civil UAV roadmap to complement the Department of Defense (DoD) effort (http://www.acq.osd.mil/uas/). Two aspects of the President's Management Agenda (refer to the document located at: www.whitehouse.gov/omb/budget/fy2002/mgmt.pdf ) are supported by this undertaking. First, it is one that will engage multiple Agencies in the effort as stakeholders and benefactors of the systems. In that sense, the market will be driven by the user requirements and applications. The second aspect is one of supporting economic development in the commercial sector. Market forecasts for the civil use of UAVs have indicated an infant market stage at present with a sustained forecasted growth. There is some difficulty in quantifying the value of the market since the typical estimate excludes system components other than the aerial platforms. Section 2.4 addresses the civil UAV market forecast and lists several independent forecasts. One conclusion that can be drawn from these forecasts is that all show a sustained growth for the duration of each long-term forecast.

  19. Joint Assessment of ETRR-2 Research Reactor Operations Program, Capabilities, and Facilities

    International Nuclear Information System (INIS)

    A joint assessment meeting was conducted at the Egyptian Atomic Energy Agency (EAEA) followed by a tour of Egyptian Second Research Reactor (ETRR-2) on March 22 and 23, 2006. The purpose of the visit was to evaluate the capabilities of the new research reactor and its operations under Action Sheet 4 between the U.S. DOE and the EAEA, ''Research Reactor Operation'', and Action Sheet 6, ''Technical assistance in The Production of Radioisotopes''. Preliminary Recommendations of the joint assessment are as follows: (1) ETRR-2 utilization should be increased by encouraging frequent and sustained operations. This can be accomplished in part by (a) Improving the supply-chain management for fresh reactor fuel and alleviating the perception that the existing fuel inventory should be conserved due to unreliable fuel supply; and (b) Promulgating a policy for sample irradiation priority that encourages the use of the reactor and does not leave the decision of when to operate entirely at the discretion of reactor operations staff. (2) Each experimental facility in operation or built for a single purpose should be reevaluated to focus on those that most meet the goals of the EAEA strategic business plan. Temporary or long-term elimination of some experimental programs might be necessary to provide more focused utilization. There may be instances of emerging reactor applications for which no experimental facility is yet designed or envisioned. In some cases, an experimental facility may have a more beneficial use than the purpose for which it was originally designed. For example, (a) An effective Boron Neutron Capture Therapy (BNCT) program requires nearby high quality medical facilities. These facilities are not available and are unlikely to be constructed near the Inshas site. Further, the BNCT facility is not correctly designed for advanced research and therapy programs using epithermal neutrons. (b) The ETRR-2 is frequently operated to provide color-enhanced gemstones but is

  20. Assessing organizational readiness for depression care quality improvement: relative commitment and implementation capability

    OpenAIRE

    Rubenstein, Lisa V; Danz, Marjorie S; Crain, A. Lauren; Glasgow, Russell E.; Whitebird, Robin R.; Solberg, Leif I.

    2014-01-01

    Background Depression is a major cause of morbidity and cost in primary care patient populations. Successful depression improvement models, however, are complex. Based on organizational readiness theory, a practice’s commitment to change and its capability to carry out the change are both important predictors of initiating improvement. We empirically explored the links between relative commitment (i.e., the intention to move forward within the following year) and implementation capability. Me...

  1. Assessing Risk Management Capability of Public Sector Organizations Related to PPP Scheme Development for Water Supply in Indonesia

    Directory of Open Access Journals (Sweden)

    Pangeran M.H.

    2012-01-01

    Full Text Available The success of Public Private Partnership (PPP for water supply investment is inseparable from the capability of risk management of the parties within the project. This study investigates the risk management capability of Indonesian local public sector organizations that are potentially involved in PPP schemes for water supply. A risk management maturity model based assessment tool probing the culture, process, experience, application and partnership aspects is used in the survey. The model describes risk management capability in four levels (ad-hoc, initial, competent, excellent. The survey shows that their risk management capability is still in-average at the initial stage (level 2, meaning that the adopted risk management postures are mostly supported only by unstructured, ad-hoc and non-formal processes. The result of this study can help decision makers in choosing appropriate risk management methods and tools to be used by the local public authorities for managing risks in PPP schemes.

  2. Joint Assessment of ETRR-2 Research Reactor Operations Program, Capabilities, and Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Bissani, M; O' Kelly, D S

    2006-05-08

    A joint assessment meeting was conducted at the Egyptian Atomic Energy Agency (EAEA) followed by a tour of Egyptian Second Research Reactor (ETRR-2) on March 22 and 23, 2006. The purpose of the visit was to evaluate the capabilities of the new research reactor and its operations under Action Sheet 4 between the U.S. DOE and the EAEA, ''Research Reactor Operation'', and Action Sheet 6, ''Technical assistance in The Production of Radioisotopes''. Preliminary Recommendations of the joint assessment are as follows: (1) ETRR-2 utilization should be increased by encouraging frequent and sustained operations. This can be accomplished in part by (a) Improving the supply-chain management for fresh reactor fuel and alleviating the perception that the existing fuel inventory should be conserved due to unreliable fuel supply; and (b) Promulgating a policy for sample irradiation priority that encourages the use of the reactor and does not leave the decision of when to operate entirely at the discretion of reactor operations staff. (2) Each experimental facility in operation or built for a single purpose should be reevaluated to focus on those that most meet the goals of the EAEA strategic business plan. Temporary or long-term elimination of some experimental programs might be necessary to provide more focused utilization. There may be instances of emerging reactor applications for which no experimental facility is yet designed or envisioned. In some cases, an experimental facility may have a more beneficial use than the purpose for which it was originally designed. For example, (a) An effective Boron Neutron Capture Therapy (BNCT) program requires nearby high quality medical facilities. These facilities are not available and are unlikely to be constructed near the Inshas site. Further, the BNCT facility is not correctly designed for advanced research and therapy programs using epithermal neutrons. (b) The ETRR-2 is frequently operated to

  3. Assessment of national reach-back capabilities in the interception of suspected special nuclear materials using simulated data

    International Nuclear Information System (INIS)

    The capabilities of a number of national reach-back entities in situations involving possible interdiction of nuclear materials was assessed. The assessment was conducted as a training exercise using simulated gamma spectra of a range of materials typical of those that may trigger border alarms, some of which included nuclear materials of various types. Responses indicated that the majority of participants were in a position to highlight the potential presence of such materials even in the presence of shielding or masking materials. Cases where participants had greater difficulty in indicating the presence of nuclear material involved materials with which the majority of participants were unfamiliar. Even though conducted as an exercise, results indicate that national reach-back entities can perform adequately but further enhancement of capabilities through training assessments may increase the efficacy of the expert assistance they provide to first responders. (author)

  4. University-Industry Research Collaboration: A Model to Assess University Capability

    Science.gov (United States)

    Abramo, Giovanni; D'Angelo, Ciriaco Andrea; Di Costa, Flavia

    2011-01-01

    Scholars and policy makers recognize that collaboration between industry and the public research institutions is a necessity for innovation and national economic development. This work presents an econometric model which expresses the university capability for collaboration with industry as a function of size, location and research quality. The…

  5. Measuring innovation capability - Assessing collaborative performance in product-service system innovation

    OpenAIRE

    Wallin, Johanna; Larsson, Andreas; Isaksson, Ola; Larsson, Tobias

    2011-01-01

    This paper reports on a qualitative study, carried out at a Swedish aero engine manufacturer. The study was initiated to explore key indicators related to innovation capability in a Product-Service System (PSS) context. Developing PSS changes the dynamics of collaboration, since the offering of such systems usually involves a network of partners sharing the responsibility for a delivered function over a full lifecycle. In particular, this paper focuses on describing aspects related to externa...

  6. Keynote Address: Rev. Mark Massa

    Science.gov (United States)

    Massa, Mark S.

    2011-01-01

    Rev. Mark S. Massa, S.J., is the dean and professor of Church history at the School of Theology and Ministry at Boston College. He was invited to give a keynote to begin the third Catholic Higher Education Collaborative Conference (CHEC), cosponsored by Boston College and Fordham University. Fr. Massa's address posed critical questions about…

  7. Assessment of radiation protection training needs and capabilities in Europe: Results of the ENETRAP survey

    International Nuclear Information System (INIS)

    on that, the mutual recognition for radiation protection courses and the acquired competencies of Qualified Experts, the ENETRAP project is working on a European harmonized approach of E and T programs in radiation protection. In a first phase of the ENETRAP project; a questionnaire was set up, the objective of this questionnaire being to elicit detailed information which will enable us to: assess the actual training needs in the EU Member States and Candidate States; understand the various regulatory aspects and consequently propose minimum requirements for mutual recognition of RPEs and RPOs; collate details of the various training and education activities available in the EU Member and Candidate States, and; review the content, structure and methods of these training and education activities. Hereto, an extensive list of questions was set up addressing the following topics: numbers of RPEs; identification of practices; national capabilities for education and training in radiological protection; regulatory requirements and; recognition. This questionnaire was sent out to 31 countries, i.e. the European Member States, the Candidate States, and the Associated States Norway and Switzerland. This paper will summarize the results of this questionnaire and the implementation these results into the construction of the E and T programmes, namely the European Master in Radiation Protection (EMRP - to start in September 2007) and the ENETRAP training scheme, being a revision of the Saclay based European Radiation Protection Course ERPC. A preliminary programme of both initiatives uses a modular approach and puts forward 2 parts : a common basis, and a series of specialized modules on occupational radiation protection in nuclear power plants and fuel cycle industry, the medical sector, non-nuclear industry and research laboratories, waste and disposal sites, etc. The EMRP and ENETRAP training scheme are planned to run (partly) in parallel, so that an overlap can be made

  8. Model-Based Real Time Assessment of Capability Left for Spacecraft Under Failure Mode Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed project is aimed at developing a model based diagnostics system for spacecraft that will allow real time assessment of its state, while it is impacted...

  9. Assessing the Dengue Diagnosis Capability Gap in the Military Health System.

    Science.gov (United States)

    Pal, Subhamoy; Jasper, Louis E; Lawrence, Kendra L; Walter, Maureen; Gilliland, Theron; Dauner, Allison L; Palys, Thomas J; Wu, Shuenn-Jue L

    2016-08-01

    Dengue, one of the most widespread infectious diseases, has affected U.S. military readiness throughout history. We explored the dengue diagnosis capability gap by circulating a questionnaire among military end users to determine in what capacity diagnostic test results are needed and how these results would be used at various roles of care in the Military Health System. Results were used to generate target product profiles for potential diagnostic tests. We determined that at far-forward locations, diagnostic tests need to be rugged and easy to use and are primarily needed to inform medical evacuation decisions. In mobile or fixed hospitals, diagnostics can be less portable but must be accurate enough to inform patient care decisions reliably. We then evaluated the suitability of using rapid diagnostic tests and enzyme-linked immunosorbent assays based on published performance characteristics, and we used a model to determine positive and negative predictive values in certain simulated deployments. In far-forward settings, a rapid diagnostic test comprising both antigen- and antibody-based detection can fulfill the capability gap with reasonable accuracy, whereas at higher roles of care immunoglobulin M-enzyme-linked immunosorbent assay was determined to be the most suitable option. PMID:27483511

  10. Capability Aggregation in the U.S.-Japan Alliance : An assessment of Japan’s impact on U.S. Ballistic Missile Defense (BMD) capabilities

    OpenAIRE

    2011-01-01

    As part of its unprecedented military modernization campaign, China’s development of advanced anti-access capabilities is driving a competition between offensive and defensive missile capabilities in the Asia-Pacific region. Meanwhile, the U.S. is increasingly turning towards its allies, emphasizing the need for strong cooperative relationships and burden sharing in the development of defense architectures against the threat of missile attacks on itself, its deployed troops, and its friends a...

  11. Using rapid environmental assessment to improve the hazard prediction and assessment capability for weapons of mass destruction

    OpenAIRE

    Ross, Victor B

    2003-01-01

    Approved for public release, distribution is unlimited The Oceanographer of the Navy is responsible for the environmental data portion of the "4-D cube". This is a new concept that creates a Virtual Natural Environment that must be capable of rapid environmental updates. This research investigates using in situ atmospheric measurements to improve the performance of the Navy mesoscale model, Coupled Ocean-Atmosphere Mesoscale Prediction System. These enhanced, operational model fo...

  12. An Assessment of Nondestructive Evaluation Capability for Complex Additive Manufacturing Aerospace Components

    Science.gov (United States)

    Walker, James; Beshears, Ron; Lambert, Dennis; Tilson, William

    2016-01-01

    The primary focus of this work is to investigate some of the fundamental relationships between processing, mechanical testing, materials characterization, and NDE for additively manufactured (AM) components using the powder bed fusion direct melt laser sintered process. The goal is to understand the criticality of defects unique to the AM process and then how conventional nondestructive evaluation methods as well as some of the more non-traditional methods such as computed tomography, are effected by the AM material. Specific defects including cracking, porosity and partially/unfused powder will be addressed. Besides line-of-site NDE, as appropriate these inspection capabilities will be put into the context of complex AM geometries where hidden features obscure, or inhibit traditional NDE methods.

  13. Introductory materials for committee members: 1) instructions for the Los Alamos National Laboratory fiscal year 2010 capability reviews 2) NPAC strategic capability planning 3) Summary self-assessment for the nuclear and particle physics, astrophysics an

    Energy Technology Data Exchange (ETDEWEB)

    Redondo, Antonio [Los Alamos National Laboratory

    2010-01-01

    Los Alamos National Laboratory (LANL) uses external peer review to measure and continuously improve the quality of its science, technology and engineering (STE). LANL uses capability reviews to assess the STE quality and institutional integration and to advise Laboratory Management on the current and future health of the STE. Capability reviews address the STE integration that LANL uses to meet mission requirements. STE capabilities are define to cut across directorates providing a more holistic view of the STE quality, integration to achieve mission requirements, and mission relevance. The scope of these capabilities necessitate that there will be significant overlap in technical areas covered by capability reviews (e.g., materials research and weapons science and engineering). In addition, LANL staff may be reviewed in different capability reviews because of their varied assignments and expertise. LANL plans to perform a complete review of the Laboratory's STE capabilities (hence staff) in a three-year cycle. The principal product of an external review is a report that includes the review committee's assessments, commendations, and recommendations for STE. The Capability Review Committees serve a dual role of providing assessment of the Laboratory's technical contributions and integration towards its missions and providing advice to Laboratory Management. The assessments and advice are documented in reports prepared by the Capability Review Committees that are delivered to the Director and to the Principal Associate Director for Science, Technology and Engineering (PADSTE). This report will be used by Laboratory Management for STE assessment and planning. The report is also provided to the Department of Energy (DOE) as part of LANL's Annual Performance Plan and to the Los Alamos National Security (LANS) LLC's Science and Technology Committee (STC) as part of its responsibilities to the LANS Board of Governors.

  14. A hybrid MCDM framework combined with DEMATEL-based ANP to evaluate enterprise technological innovation capabilities assessment

    Directory of Open Access Journals (Sweden)

    Meng-Jong Kuan

    2014-08-01

    Full Text Available The efficient evaluation of technological innovation capabilities of enterprises is an important factor to enhance competitiveness. This paper aims to assess and to rank technological innovation evaluation criteria in order to provide a practical insight of systematic analysis by gathering the qualified experts’ opinions combined with three methods of multi-criteria decision making approach. A framework is proposed and uses a novel hybrid multiple criteria decision-making (MCDM model to address the dependence relationships of criteria with the aid of the Decision-Making Trial and Evaluation Laboratory (DEMATEL, analytical network process (ANP and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje. The study reports that the interaction between criteria is essential and influences technological innovation capabilities; furthermore, this ranking development of technological innovation capabilities assessment is also one of key management tools for managements of other related high- tech enterprises. Managers can then judge the need to improve and determine which criteria provide the most effective direction towards improvement.

  15. Total System Performance Assessment, 1993: An evaluation of the potential Yucca Mountain repository, B00000000-01717-2200-00099, Rev. 01

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, R.W.; Dale, T.F.; McNeish, J.A. [INTERA, Inc., Las Vegas, NV (United States)

    1994-03-01

    Total System Performance Assessments are an important component in the evaluation of the suitability of Yucca Mountain, Nevada as a potential site for a mined geologic repository for the permanent disposal of high-level radioactive wastes in the United States. The Total System Performance Assessments are conducted iteratively during the site characterization to identify issues which should be addressed by the characterization and design activities as well as providing input to regulatory/licensing and programmatic decisions. During fiscal years 1991 and 1992, the first iteration of Total System Performance Assessment (hereafter referred to as TSPA 1991) was completed by Sandia National Laboratories and Pacific Northwest Laboratory. Beginning in fiscal year 1993, the Civilian Radioactive Waste Management System Management and Operating Contractor was assigned the responsibility to plan, coordinate, and contribute to the second iteration of Total System Performance Assessment (hereafter referred to as TSPA 1993). This document presents the objectives, approach, assumptions, input, results, conclusions, and recommendations associated with the Management and Operating Contractor contribution to TSPA 1993. A parallel effort was conducted by Sandia National Laboratories and is reported in Wilson et al. (1994, in press).

  16. Assessing the capabilities of hyperspectral remote sensing to map oil films on waters

    Science.gov (United States)

    Liu, Bingxin; Li, Ying; Zhu, Xueyuan

    2014-11-01

    The harm of oil spills has caused extensive public concern. Remote sensing technology has become one of the most effective means of monitoring oil spill. However, how to evaluate the information extraction capabilities of various sensors and choose the most effective one has become an important issue. The current evaluation of sensors to detect oil films was mainly using in-situ measured spectra as a reference to determine the favorable band, but ignoring the effects of environmental noise and spectral response function. To understand the precision and accuracy of environment variables acquired from remote sensing, it is important to evaluate the target detection sensitivity of the entire sensor-air-target system corresponding to the change of reflectivity. The measurement data associated with the evaluation is environmental noise equivalent reflectance difference (NEΔRE ), which depends on the instrument signal to noise ratio(SNR) and other image data noise (such as atmospheric variables, scattered sky light scattering and direct sunlight, etc.). Hyperion remote sensing data is taken as an example for evaluation of its oil spill detection capabilities with the prerequisite that the impact of the spatial resolution is ignored. In order to evaluate the sensor's sensitivity of the film of water, the reflectance spectral data of light diesel and crude oil film were used. To obtain Hyperion reflectance data, we used FLAASH to do the atmospheric correction. The spectral response functions of Hyperion sensor was used for filtering the measured reflectance of the oil films to the theoretic spectral response. Then, these spectral response spectra were normalized to NEΔRE, according to which, the sensitivity of the sensor in oil film detecting could be evaluated. For crude oil, the range for Hyperion sensor to identify the film is within the wavelength from 518nm to 610nm (Band 17 to Band 26 of Hyperion sensors), within which the thin film and thick film can also be

  17. Producing reflective practice capability: a textual analysis of practice learning and assessment portfolios

    OpenAIRE

    Volante, Margaret

    2013-01-01

    Within portfolios used by nurse education programmes of higher education for practice learning and assessment, reflective narrative accounts are considered evidence of practice learning outcomes. Evaluation research of portfolios used in nurse education programmes is for the most part based on student perceptions which show students are conflicted on the inclusion of reflective accounts in the portfolio. This paper examines how structural influences of the practice learning milieu shape the ...

  18. Assessing the predictive capability of randomized tree-based ensembles in streamflow modelling

    Directory of Open Access Journals (Sweden)

    S. Galelli

    2013-02-01

    Full Text Available Combining randomization methods with ensemble prediction is emerging as an effective option to balance accuracy and computational efficiency in data-driven modeling. In this paper we investigate the prediction capability of extremely randomized trees (Extra-Trees, in terms of accuracy, explanation ability and computational efficiency, in a streamflow modeling exercise. Extra-Trees are a totally randomized tree-based ensemble method that (i alleviates the poor generalization property and tendency to overfitting of traditional standalone decision trees (e.g. CART; (ii is computationally very efficient; and, (iii allows to infer the relative importance of the input variables, which might help in the ex-post physical interpretation of the model. The Extra-Trees potential is analyzed on two real-world case studies (Marina catchment (Singapore and Canning River (Western Australia representing two different morphoclimatic contexts comparatively with other tree-based methods (CART and M5 and parametric data-driven approaches (ANNs and multiple linear regression. Results show that Extra-Trees perform comparatively well to the best of the benchmarks (i.e. M5 in both the watersheds, while outperforming the other approaches in terms of computational requirement when adopted on large datasets. In addition, the ranking of the input variable provided can be given a physically meaningful interpretation.

  19. Development of cellulose-polypyrrole microfiber membranes and assessment of their capability on water softening

    Science.gov (United States)

    Barrera, C.; Arrieta, A.; Escobar, N.; Gañan, P.; Castro, C.

    2013-11-01

    The application of conducting polymer composite for water softening is based on the use of pyrrole's electrochemical properties joined with the flexibility and relatively high surface areas associated with cellulose fibers, to develop a new hybrid material that exhibits the inherent proprieties of both components. This hybrid would allow to promote an ion exchange reaction between the composite membrane and the hard water. The cellulose membranes obtained from banana plant agricultural waste (raquis), were uniform with individual and well separated fibers. The fibers were encapsulated by a continuous coating of polypyrrole by an in situ oxidative chemical polymerization. The amount of polypyrrole deposited on the fiber increased by increasing the monomer concentration, behavior that was identified through the observation of differences on the intensity of the light to dark color shift that coated the fibers after the polymerization. The ion removal capability of the membrane coted with the conducting polymer was tested using an experimental device, finding reductions on the conductivity for hard water within 23 to 66 μs/cm after 6 hours of the assay.

  20. Capability and quality assessment of rice growing hydric soils in majuli river island, assam, India

    OpenAIRE

    Bhaskara Phaneendra Bhaskar; Dipak Sarkar

    2013-01-01

    The  wetland soils in  majuli island is a unique in maintaining rice ecology and geoenvironment in Brahmaputra valley of Assam  due to increasing  rate of  bankline erosion in southern bank  and expansion of channel bars on northern banks. These hydric soils in the subgroups of aquents and aquepts are  saturated throughout year as assessed from depleted matrix with hue 10YR, 2.5Y and 5Y, chroma less than 2, stratified textures, neutral to slightly alkaline reaction, low cation exchange capaci...

  1. Agent Based Manufacturing Capability Assessment in the Extended Enterprise Using Step AP224 and XML

    Science.gov (United States)

    Ratchev, Svetan; Medani, Omar

    Data exchange in the extended enterprise is one of the most critical tasks in supporting collaborative decision-making. Companies often rely on geographically distributed suppliers for efficient product design and manufacture. Early design assessment can substantially reduce the cost of product development and production. This research proposes a new STEP AP224 EXPRESS based data model to facilitate the exchange of part and process data between distributed key agents in the early design process. The approach is illustrated using a prototype XML/CORBA environment to support the information exchange between collaborating design and manufacturing agents.

  2. The GLORIE Campaign: Assessment of the Capabilities of Airborne GNSS-R for Land Remote Sensing.

    Science.gov (United States)

    Mangiarotti, S.; Motte, E.; Zribi, M., Sr.; Fanise, P., Sr.

    2015-12-01

    In June and July 2015 an intensive flight campaign was conducted over the south west of France to test the sensitivity of Global Navigation Satellite System Reflectometry (GNSS-R) to the geophysical parameters of continental surfaces. Namely, the parameters of interest were soil moisture, soil roughness, plant water content, forest biomass and level of inland water bodies and rivers. We used the GLORI polarimetric GNSS-R instrument, collecting raw 10MSPS 2-bit IQ direct (RHCP, zenith) and reflected (RHCP and LHCP, nadir) signals at GPS L1 frequency aboard the ATR-42 aircraft of the SAFIRE fleet. Simultaneous measurement of aircraft attitude and position were recorded. The flight plan included flyovers of several areas of interests, with collocated ground truth measurements of soil moisture, soil roughness, cultivated biomass, and forest biomass. Also flyovers of ponds, lakes and river were included for power calibration and altimetry retrievals. In total, 6 flights were performed between June 19th and July 6th, representing more than 15 hours of raw data. A conventional GNSS-R processing of the data was performed in order to compute the direct and reflected complex waveforms. A preliminary data analysis based on the variations of the ratio of reflected maximum correlation amplitude in the LHCP antenna to direct maximum correlated amplitude shows measurements sensitivity to soil type, land use and incidence angle. Also, first altimetric retrievals using phase-delay techniques shows very promising results over calm waters. Current work is ongoing in order to fit the observed polarimetric measurements with innovative bistatic scattering models capable of taking into account complex geometries and land use configurations.

  3. Capabilities of Cone-Beam Computed Tomography in the Assessment of the Structure of Wrist and Hand Bones

    OpenAIRE

    А.Yu. Vasiliev, PhD, MD; N.N. Blinov, PhD, MD; Е.A. Egorova, PhD, MD; D.V. Makarova; E.G. Gorlycheva; M.O. Dutova

    2013-01-01

    An analysis of the capabilities of cone-beam computed tomography (CBCT) in the assessment of the form and structure of wrist and hand bones was the aim of the research. Cone-beam CT of wrist and hand was conducted in a group of voluntary patients, which included 40 members aged 22- 68 years. Magnetic resonance imaging (МRI) was carried out in 80.0% (n = 32) of cases, multislice computed tomography (MSCT) in 40.0% (n=16) of cases. In 62.5 % (n=25) of cases, digital microfocus radiography on X-...

  4. Administrative Circular No. 26 (Rev. 7) – May 2007

    CERN Multimedia

    HR Department

    2007-01-01

    Recognition of Merit of Staff Members Administrative Circular No. 26 (Rev. 7) is now available on the intranet site of the Human Resources Department. This circular cancels and replaces Administrative Circular No. 26 (Rev. 6) - Procedures governing the career development of staff members. Copies will shortly be available in Departmental secretariats. If you require any additional information on the new staff-member merit assessment and recognition system, you may consult the FAQ, which has been available on the Human Resources Department intranet site since February 2007. Human Resources Department Tel. 78003

  5. Binocular coordination of saccades during reading in children with clinically assessed poor vergence capabilities.

    Science.gov (United States)

    Gaertner, Chrystal; Bucci, Maria Pia; Ajrezo, Layla; Wiener-Vacher, Sylvette

    2013-07-19

    Prior studies have pointed toward a link between the saccadic and vergence systems, coordinating binocular saccadic movements. Recent studies have shown that vergence deficits in children induce poor binocular coordination during saccades, but none of them have studied ocular motility in children during a daily task such as reading. The present study tests whether vergence deficits in children perturb binocular coordination of saccades and fixation during reading. Our second objective was to explore whether vergence training could improve the quality of binocular coordination. Twelve patients (from 7.3 to 13.4 years old) complaining from vertigo but without vestibular and neurological pathology underwent orthoptic tests and were selected for our study when they presented vergence deficits. Eye movements were recorded during a reading task with a Mobile EyeBrain® Tracker video-oculography system. Data were compared to twelve age-matched controls with normal orthoptic values. While there was no statistically significant difference in saccade amplitudes between the two groups (p=0.29), patients showed higher disconjugacy during and after the saccades compared to controls (p<0.001). After orthoptic training, six patients out of the first 12 examined came back for a second oculomotor test. All showed a significant improvement of their binocular saccade coordination. We suggest that the larger disconjugacy during reading observed in patients before training could be due to poor vergence as initially assessed by orthoptic examination. Such findings support the hypothesis of a tight relationship between the saccadic and vergence systems for controlling the binocular coordination of saccades. The improvement reported after orthoptic training is in line with the hypothesis of an adaptative interaction on a premotor level between the saccadic and vergence system.

  6. Initial demonstration of the NRC's capability to conduct a performance assessment for a High-Level Waste Repository

    International Nuclear Information System (INIS)

    In order to better review licensing submittals for a High-Level Waste Repository, the US Nuclear Regulatory Commission staff has expanded and improved its capability to conduct performance assessments. This report documents an initial demonstration of this capability. The demonstration made use of the limited data from Yucca Mountain, Nevada to investigate a small set of scenario classes. Models of release and transport of radionuclides from a repository via the groundwater and direct release pathways provided preliminary estimates of releases to the accessible environment for a 10,000 year simulation time. Latin hypercube sampling of input parameters was used to express results as distributions and to investigate model sensitivities. This methodology demonstration should not be interpreted as an estimate of performance of the proposed repository at Yucca Mountain, Nevada. By expanding and developing the NRC staff capability to conduct such analyses, NRC would be better able to conduct an independent technical review of the US Department of Energy (DOE) licensing submittals for a high-level waste (HLW) repository. These activities were divided initially into Phase 1 and Phase 2 activities. Additional phases may follow as part of a program of iterative performance assessment at the NRC. The NRC staff conducted Phase 1 activities primarily in CY 1989 with minimal participation from NRC contractors. The Phase 2 activities were to involve NRC contractors actively and to provide for the transfer of technology. The Phase 2 activities are scheduled to start in CY 1990, to allow Sandia National Laboratories to complete development and transfer of computer codes and the Center for Nuclear Waste Regulatory Analyses (CNWRA) to be in a position to assist in the acquisition of the codes

  7. Comparison of capability of dynamic O2-enhanced MRI and quantitative thin-section MDCT to assess COPD in smokers

    International Nuclear Information System (INIS)

    Purpose: The purpose of this study was to directly and prospectively compare the capability of dynamic O2-enhanced MRI and quantitatively assessed thin-section MDCT to assess smokers’ COPD in a large prospective cohort. Materials and methods: The GOLD criteria for smokers were used to classify 187 smokers into four clinical stage groups as follows: smokers without COPD (n = 56) and with mild (n = 54), moderate (n = 52) and severe or very severe COPD (n = 24). All smokers underwent dynamic O2-enhanced MRI, MDCT and pulmonary function tests. Mean relative enhancement ratio and mean wash-in time on MRI and CT-based functional lung volume (CT-based FLV) as well as the ratio of airway wall area to total airway area on MDCT were computationally calculated. Then, all indexes were significantly correlated with functional parameters. To determine the efficacy of all indexes for clinical stage classification, the indexes for the four clinical groups were statistically compared by using Tukey's honestly significant difference multiple comparison test. Results: All indexes had significant correlations with functional parameters (p 2-enhanced MRI for assessment of COPD in smokers is potentially as efficacious as quantitatively assessed thin-section MDCT.

  8. Technological capability assessment of suppliers to support product development: case study on a buses and coaches manufacturer

    Directory of Open Access Journals (Sweden)

    Lucas Comerlato

    2013-05-01

    Full Text Available Supply chain management has become a critical issue in the global collaboration scenario. Suppliers are not expected to provide just commodities or pre-defined components, but also collaborative engineering design solutions within the product development cycle. Thus, the selection criteria for defining supply partner go beyond the production and logistic capabilities, but must also include technical and engineering competence. This, in some sense, can be considered a common scenario of big companies, but is still challenging when dealing with SME´s. This work discusses how SME´s can be included in a supply chains taking in consideration a set of parameters to assess their technical competence related to product development collaboration. A set of eight parameters has been proposed to assess the engineering team competence, physical and technological structure and further legal responsibility. For each parameter values and weights were defined also. The assessment was applied to three companies that are suppliers of a buses and coaches manufacturer from Rio Grande do Sul, Brazil. The results show that even when dealing with objective parameters, the suppliers and costumer can have different perceptions about same issues.

  9. Application of Benchmark Examples to Assess the Single and Mixed-Mode Static Delamination Propagation Capabilities in ANSYS

    Science.gov (United States)

    Krueger, Ronald

    2012-01-01

    The application of benchmark examples for the assessment of quasi-static delamination propagation capabilities is demonstrated for ANSYS. The examples are independent of the analysis software used and allow the assessment of the automated delamination propagation in commercial finite element codes based on the virtual crack closure technique (VCCT). The examples selected are based on two-dimensional finite element models of Double Cantilever Beam (DCB), End-Notched Flexure (ENF), Mixed-Mode Bending (MMB) and Single Leg Bending (SLB) specimens. First, the quasi-static benchmark examples were recreated for each specimen using the current implementation of VCCT in ANSYS . Second, the delamination was allowed to propagate under quasi-static loading from its initial location using the automated procedure implemented in the finite element software. Third, the load-displacement relationship from a propagation analysis and the benchmark results were compared, and good agreement could be achieved by selecting the appropriate input parameters. The benchmarking procedure proved valuable by highlighting the issues associated with choosing the input parameters of the particular implementation. Overall the results are encouraging, but further assessment for three-dimensional solid models is required.

  10. A Hybrid Multi-Criteria Decision Model for Technological Innovation Capability Assessment: Research on Thai Automotive Parts Firms

    Directory of Open Access Journals (Sweden)

    Sumrit Detcharat

    2013-01-01

    Full Text Available The efficient appraisal of technological innovation capabilities (TICs of enterprises is an important factor to enhance competitiveness. This study aims to evaluate and rank TICs evaluation criteria in order to provide a practical insight of systematic analysis by gathering the qualified experts’ opinions combined with three methods of multi-criteria decision making approach. Firstly, Fuzzy Delphi method is used to screen TICs evaluation criteria from the recent published researches. Secondly, the Analytic Hierarchy Process is utilized to compute the relative important weights. Lastly, the VIKOR method is used to rank the enterprises based on TICs evaluation criteria. An empirical study is applied for Thai automotive parts firms to illustrate the proposed methods. This study found that the interaction between criteria is essential and influences TICs; furthermore, this ranking development of TICs assessment is also one of key management tools to simply facilitate and offer a new mindset for managements of other related industries.

  11. Capabilities of Cone-Beam Computed Tomography in the Assessment of the Structure of Wrist and Hand Bones

    Directory of Open Access Journals (Sweden)

    А.Yu. Vasiliev, PhD, MD

    2013-06-01

    Full Text Available An analysis of the capabilities of cone-beam computed tomography (CBCT in the assessment of the form and structure of wrist and hand bones was the aim of the research. Cone-beam CT of wrist and hand was conducted in a group of voluntary patients, which included 40 members aged 22- 68 years. Magnetic resonance imaging (МRI was carried out in 80.0% (n = 32 of cases, multislice computed tomography (MSCT in 40.0% (n=16 of cases. In 62.5 % (n=25 of cases, digital microfocus radiography on X-ray unit Pardus (Russia and standard radiography of wrist and hand were conducted. According to the results of the research, CBCT shows a high efficiency in detection of form, measurements and structural changes of bones of the anatomic region.

  12. Nitrate reduction in geologically heterogeneous catchments — A framework for assessing the scale of predictive capability of hydrological models

    Energy Technology Data Exchange (ETDEWEB)

    Refsgaard, Jens Christian, E-mail: jcr@geus.dk [Geological Survey of Denmark and Greenland (GEUS) (Denmark); Auken, Esben [Department of Earth Sciences, Aarhus University (Denmark); Bamberg, Charlotte A. [City of Aarhus (Denmark); Christensen, Britt S.B. [Geological Survey of Denmark and Greenland (GEUS) (Denmark); Clausen, Thomas [DHI, Hørsholm (Denmark); Dalgaard, Esben [Department of Earth Sciences, Aarhus University (Denmark); Effersø, Flemming [SkyTEM Aps, Beder (Denmark); Ernstsen, Vibeke [Geological Survey of Denmark and Greenland (GEUS) (Denmark); Gertz, Flemming [Knowledge Center for Agriculture, Skejby (Denmark); Hansen, Anne Lausten [Department of Geosciences and Natural Resource Management, University of Copenhagen (Denmark); He, Xin [Geological Survey of Denmark and Greenland (GEUS) (Denmark); Jacobsen, Brian H. [Department of Food and Resource Economics, University of Copenhagen (Denmark); Jensen, Karsten Høgh [Department of Geosciences and Natural Resource Management, University of Copenhagen (Denmark); Jørgensen, Flemming; Jørgensen, Lisbeth Flindt [Geological Survey of Denmark and Greenland (GEUS) (Denmark); Koch, Julian [Department of Geosciences and Natural Resource Management, University of Copenhagen (Denmark); Nilsson, Bertel [Geological Survey of Denmark and Greenland (GEUS) (Denmark); Petersen, Christian [City of Odder (Denmark); De Schepper, Guillaume [Université Laval, Québec (Canada); Schamper, Cyril [Department of Earth Sciences, Aarhus University (Denmark); and others

    2014-01-01

    In order to fulfil the requirements of the EU Water Framework Directive nitrate load from agricultural areas to surface water in Denmark needs to be reduced by about 40%. The regulations imposed until now have been uniform, i.e. the same restrictions for all areas independent of the subsurface conditions. Studies have shown that on a national basis about 2/3 of the nitrate leaching from the root zone is reduced naturally, through denitrification, in the subsurface before reaching the streams. Therefore, it is more cost-effective to identify robust areas, where nitrate leaching through the root zone is reduced in the saturated zone before reaching the streams, and vulnerable areas, where no subsurface reduction takes place, and then only impose regulations/restrictions on the vulnerable areas. Distributed hydrological models can make predictions at grid scale, i.e. at much smaller scale than the entire catchment. However, as distributed models often do not include local scale hydrogeological heterogeneities, they are typically not able to make accurate predictions at scales smaller than they are calibrated. We present a framework for assessing nitrate reduction in the subsurface and for assessing at which spatial scales modelling tools have predictive capabilities. A new instrument has been developed for airborne geophysical measurements, Mini-SkyTEM, dedicated to identifying geological structures and heterogeneities with horizontal and lateral resolutions of 30–50 m and 2 m, respectively, in the upper 30 m. The geological heterogeneity and uncertainty are further analysed by use of the geostatistical software TProGS by generating stochastic geological realisations that are soft conditioned against the geophysical data. Finally, the flow paths within the catchment are simulated by use of the MIKE SHE hydrological modelling system for each of the geological models generated by TProGS and the prediction uncertainty is characterised by the variance between the

  13. Nitrate reduction in geologically heterogeneous catchments — A framework for assessing the scale of predictive capability of hydrological models

    International Nuclear Information System (INIS)

    In order to fulfil the requirements of the EU Water Framework Directive nitrate load from agricultural areas to surface water in Denmark needs to be reduced by about 40%. The regulations imposed until now have been uniform, i.e. the same restrictions for all areas independent of the subsurface conditions. Studies have shown that on a national basis about 2/3 of the nitrate leaching from the root zone is reduced naturally, through denitrification, in the subsurface before reaching the streams. Therefore, it is more cost-effective to identify robust areas, where nitrate leaching through the root zone is reduced in the saturated zone before reaching the streams, and vulnerable areas, where no subsurface reduction takes place, and then only impose regulations/restrictions on the vulnerable areas. Distributed hydrological models can make predictions at grid scale, i.e. at much smaller scale than the entire catchment. However, as distributed models often do not include local scale hydrogeological heterogeneities, they are typically not able to make accurate predictions at scales smaller than they are calibrated. We present a framework for assessing nitrate reduction in the subsurface and for assessing at which spatial scales modelling tools have predictive capabilities. A new instrument has been developed for airborne geophysical measurements, Mini-SkyTEM, dedicated to identifying geological structures and heterogeneities with horizontal and lateral resolutions of 30–50 m and 2 m, respectively, in the upper 30 m. The geological heterogeneity and uncertainty are further analysed by use of the geostatistical software TProGS by generating stochastic geological realisations that are soft conditioned against the geophysical data. Finally, the flow paths within the catchment are simulated by use of the MIKE SHE hydrological modelling system for each of the geological models generated by TProGS and the prediction uncertainty is characterised by the variance between the

  14. HIV-1 tat and rev upregulates osteoclast bone resorption

    Directory of Open Access Journals (Sweden)

    Nicholas Chew

    2014-11-01

    Full Text Available Introduction: Disruption in bone homeostasis with increased osteoclastic resorption may lead to osteoporosis. HIV tat has been found to increase differentiation of precursor cells into osteoclast (OC (1. Presence of soluble HIV proteins in virally suppressed HIV patients on ART may drive a bone resorption phenotype. We investigated the role of soluble HIV proteins (tat, gp120 Mn and Bal, rev and p55-gag on osteoclastogenesis and OC resorptive capacity. Methods: Mouse monocyte RAW 264.7 cells were cultured in vitro and induced to differentiate into OCs with 50 ng/mL RANKL and 25 ng/mL mCSF. Medium was supplemented with 100 ng/mL of recombinant HIV tat, gp120 (Mn and Bal, rev, nef and p55-gag, respectively, with zolendronate as negative control. Differentiated OCs were stained for TRAP and counted. OC resorption function was examined by culturing differentiated OCs (in the presence of respective HIV proteins on dentin-coated plates and examining the following (i sealing zone formation, (ii volume of resorption pits and (iii area of resorption pits per field using confocal microscopy. Expression of OC specific genes including NFATc1 and cathepsin K was investigated by qPCR. Reactive oxygen species (ROS production is essential in RANKL-induced OC differentiation (2,3; effect of these proteins on ROS production was assessed using the fluorescent H2DCFH-DA. Mean fluorescence intensity was then measured by flow cytometry. TNFα production by OC precursors when incubated with tat and rev was measured by ELISA. Results: Tat and rev treatment was associated with increased OC formation by 70 and 26%, respectively (p<0.01, relative to control, while zolendronate significantly inhibited OC formation by 75%. Gp120 Mn and Bal, nef and p55-gag treatment had no effect on OC differentiation. Interestingly, neither tat nor rev treatment caused significant increases in sealing zone formation but increased dentin resorption pit area by 28 and 19%, respectively, and

  15. Investigations of migratory birds during operation of Horns Rev offshore wind farm: Preliminary note of analysis of data from spring 2004

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

    2004-07-01

    In February 1998, the Ministry of the Environment gave Elsam A/S and Eltra A.m.b.a. approval to erect a wind farm, capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk off the west coast of Jutland. Construction activities at Horns Rev started in September 2001 and were finished in summer 2002. The entire project has been organised as a demonstration project to assess the technical, economic and environmental constraints on the future development of electric power production in Danish offshore environments. Within the framework of the environmental programme, bird investigations have been carried out in relation to the risk of collision between birds and wind turbines since 2002. To provide the latest update on the results from the bird investigations, this note presents results compiled during spring 2004 and deals with a preliminary analysis of effects on birds present at Horns Rev during commercial operation of the Horns Rev wind farm. Due to the remoteness of the area it has not been possible to obtain base-line investigation of bird occurrence and behaviour at the wind farm site. (au)

  16. Qualification and application of nuclear reactor accident analysis code with the capability of internal assessment of uncertainty

    International Nuclear Information System (INIS)

    This thesis presents an independent qualification of the CIAU code ('Code with the capability of - Internal Assessment of Uncertainty') which is part of the internal uncertainty evaluation process with a thermal hydraulic system code on a realistic basis. This is done by combining the uncertainty methodology UMAE ('Uncertainty Methodology based on Accuracy Extrapolation') with the RELAP5/Mod3.2 code. This allows associating uncertainty band estimates with the results obtained by the realistic calculation of the code, meeting licensing requirements of safety analysis. The independent qualification is supported by simulations with RELAP5/Mod3.2 related to accident condition tests of LOBI experimental facility and to an event which has occurred in Angra 1 nuclear power plant, by comparison with measured results and by establishing uncertainty bands on safety parameter calculated time trends. These bands have indeed enveloped the measured trends. Results from this independent qualification of CIAU have allowed to ascertain the adequate application of a systematic realistic code procedure to analyse accidents with uncertainties incorporated in the results, although there is an evident need of extending the uncertainty data base. It has been verified that use of the code with this internal assessment of uncertainty is feasible in the design and license stages of a NPP. (author)

  17. Wave power plant at Horns Rev. Screening[Denmark]; Boelgekraftanlaeg ved Horns Rev. Screening

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Hans C.; Nielsen, Kim; Steenstrup, P.R.; Friis-Madsen, E.; Wigant, L.

    2005-12-15

    The objective for the analysis has been to establish data for the sea at Horns Rev wind farm in the North Sea in order to assess the opportunity for using the site as test site for demonstration of wave energy devices exemplified by three different devices under development in Denmark. For comparison alternative sites like Hanstholm, Samsoe and Nissum Bredning are also assessed as well as the test centre EMEC at the Orkney Islands and the proposed test site Wave Hub at the north coast of Cornwall. The analysis shows that it is possible without major technical problems to connect 2-4 MW power generated by 3 different wave energy devices (AquaBuOY, Wave Star Energy and Wave Dragon) to the wind farm at Horns Rev (www.hornsrev.dk). The expenses for connection and regulation within the wind farm is about 200,000 DKK (30,00 EURO). On top of this comes the cost for individual sub sea cable connection to the wave devices, pull in of the sub sea cable through the existing J-tube in turbine T04 and the necessary regulation/control system in the individual wave devices to avoid damaging the power system in case of too high production. The analysis of the co-production of wind and wave power is dealt with in a separate report which shows that over a time period of half to one hour the time variation for wind generated electricity is 3 times as large as for wave energy generated power based on the actual measurement at Horns Rev. Further on the analysis shows that the wave generated power is more predictable than wind energy generated power as the power from the waves first is present about 2 hours after the wind is acting and last for 3 to 6 hours after the wind dies out; 6 to 12 hours with wind from west. The time is off course strongly depending of the direction of the wind i.e. the fetch. As this special report has a more general scope than the analysis as such it is reported in English (Annex Report II). The analysis shows that it is up to the individual device developer

  18. Capability Paternalism

    NARCIS (Netherlands)

    Claassen, R.J.G.

    2014-01-01

    A capability approach prescribes paternalist government actions to the extent that it requires the promotion of specific functionings, instead of the corresponding capabilities. Capability theorists have argued that their theories do not have much of these paternalist implications, since promoting c

  19. A JOINT VENTURE MODEL FOR ASSESSMENT OF PARTNER CAPABILITIES: THE CASE OF ESKOM ENTERPRISES AND THE AFRICAN POWER SECTOR

    Directory of Open Access Journals (Sweden)

    Y.V. Soni

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: This article investigates the concept of joint ventures in the international energy sector and develops a joint venture model, as a business development and assessment tool. The joint venture model presents a systematic method that relies on modern business intelligence to assess a potential business venture by using a balanced score card technique to screen potential partners, based on their technological and financial core capabilities. The model can be used by business development managers to harness the potential of joint ventures to create economic growth and sustainable business expansion. Furthermore, partnerships with local companies can help to mitigate econo-political risk, and facilitate buy-in from the national governments that are normally the primary stakeholders in the energy sector ventures (directly or indirectly. The particular case of Eskom Enterprises (Pty Ltd, a wholly owned subsidiary of Eskom, is highlighted.

    AFRIKAANSE OPSOMMING: Hierdie artikel ondersoek die begrip gesamentlike onderneming in die internasionale energiesektor en ontwikkel 'n gesamentlike-onderneming-model as 'n sake-ontwikkeling- en takseermodel. Die gesamentlike-onderneming-model bied 'n stelselmatige metode wat op moderne sake-intelligensie staat maak om 'n potensiële sake-onderneming op grond van die tegnologiese en finansiële kernvermoëns daarvan te takseer deur 'n gebalanseerdepuntekaart-tegniek te gebruik. Die model kan deur sake-ontwikkelingsbestuurders gebruik word om die potensiaal van gesamentlike ondernemings in te span om ekonomiese groei en volhoubare sake-uitbreiding daar te stel. Verder kan venootskappe met plaaslike maatskappye help om die ekonomiese risiko te verminder en inkoop te vergemaklik van die nasionale regerings wat gewoonlik die primêre belanghebbendes in die energiesektorondernemings is (hetsy regstreeks of onregstreeks. Die besondere geval van Eskom Enterprises (Edms Bpk, 'n vol filiaal van Eskom

  20. Nitrate reduction in geologically heterogeneous catchments--a framework for assessing the scale of predictive capability of hydrological models.

    Science.gov (United States)

    Refsgaard, Jens Christian; Auken, Esben; Bamberg, Charlotte A; Christensen, Britt S B; Clausen, Thomas; Dalgaard, Esben; Effersø, Flemming; Ernstsen, Vibeke; Gertz, Flemming; Hansen, Anne Lausten; He, Xin; Jacobsen, Brian H; Jensen, Karsten Høgh; Jørgensen, Flemming; Jørgensen, Lisbeth Flindt; Koch, Julian; Nilsson, Bertel; Petersen, Christian; De Schepper, Guillaume; Schamper, Cyril; Sørensen, Kurt I; Therrien, Rene; Thirup, Christian; Viezzoli, Andrea

    2014-01-15

    In order to fulfil the requirements of the EU Water Framework Directive nitrate load from agricultural areas to surface water in Denmark needs to be reduced by about 40%. The regulations imposed until now have been uniform, i.e. the same restrictions for all areas independent of the subsurface conditions. Studies have shown that on a national basis about 2/3 of the nitrate leaching from the root zone is reduced naturally, through denitrification, in the subsurface before reaching the streams. Therefore, it is more cost-effective to identify robust areas, where nitrate leaching through the root zone is reduced in the saturated zone before reaching the streams, and vulnerable areas, where no subsurface reduction takes place, and then only impose regulations/restrictions on the vulnerable areas. Distributed hydrological models can make predictions at grid scale, i.e. at much smaller scale than the entire catchment. However, as distributed models often do not include local scale hydrogeological heterogeneities, they are typically not able to make accurate predictions at scales smaller than they are calibrated. We present a framework for assessing nitrate reduction in the subsurface and for assessing at which spatial scales modelling tools have predictive capabilities. A new instrument has been developed for airborne geophysical measurements, Mini-SkyTEM, dedicated to identifying geological structures and heterogeneities with horizontal and lateral resolutions of 30-50 m and 2m, respectively, in the upper 30 m. The geological heterogeneity and uncertainty are further analysed by use of the geostatistical software TProGS by generating stochastic geological realisations that are soft conditioned against the geophysical data. Finally, the flow paths within the catchment are simulated by use of the MIKE SHE hydrological modelling system for each of the geological models generated by TProGS and the prediction uncertainty is characterised by the variance between the

  1. Assessment of Gravity Wave Momentum Flux Measurement Capabilities by Meteor Radars Having Different Transmitter Power and Antenna Configurations

    Science.gov (United States)

    Fritts, D. C.; Janches, D.; Hocking, W. K.; Mitchell, N. J.; Taylor, M. J.

    2011-01-01

    Measurement capabilities of five meteor radars are assessed and compared to determine how well radars having different transmitted power and antenna configurations perform in defining mean winds, tidal amplitudes, and gravity wave (GW) momentum fluxes. The five radars include two new-generation meteor radars on Tierra del Fuego, Argentina (53.8 deg S) and on King George Island in the Antarctic (62.1 deg S) and conventional meteor radars at Socorro, New Mexico (34.1 deg N, 106.9 deg W), Bear Lake Observatory, Utah (approx 41.9 deg N, 111.4 deg W), and Yellowknife, Canada (62.5 deg N, 114.3 deg W). Our assessment employs observed meteor distributions for June of 2009, 2010, or 2011 for each radar and a set of seven test motion fields including various superpositions of mean winds, constant diurnal tides, constant and variable semidiurnal tides, and superposed GWs having various amplitudes, scales, periods, directions of propagation, momentum fluxes, and intermittencies. Radars having higher power and/or antenna patterns yielding higher meteor counts at small zenith angles perform well in defining monthly and daily mean winds, tidal amplitudes, and GW momentum fluxes, though with expected larger uncertainties in the daily estimates. Conventional radars having lower power and a single transmitting antenna are able to describe monthly mean winds and tidal amplitudes reasonably well, especially at altitudes having the highest meteor counts. They also provide qualitative estimates of GW momentum fluxes at the altitudes having the highest meteor counts; however, these estimates are subject to uncertainties of approx 20 to 50% and uncertainties rapidly become excessive at higher and lower altitudes. Estimates of all quantities degrade somewhat for more complex motion fields.

  2. Assessment of gravity wave momentum flux measurement capabilities by meteor radars having different transmitter power and antenna configurations

    Science.gov (United States)

    Fritts, D. C.; Janches, D.; Hocking, W. K.; Mitchell, N. J.; Taylor, M. J.

    2012-05-01

    Measurement capabilities of five meteor radars are assessed and compared to determine how well radars having different transmitted power and antenna configurations perform in defining mean winds, tidal amplitudes, and gravity wave (GW) momentum fluxes. The five radars include two new-generation meteor radars on Tierra del Fuego, Argentina (53.8°S) and on King George Island in the Antarctic (62.1°S) and conventional meteor radars at Socorro, New Mexico (34.1°N, 106.9°W), Bear Lake Observatory, Utah (˜41.9°N, 111.4°W), and Yellowknife, Canada (62.5°N, 114.3°W). Our assessment employs observed meteor distributions for June of 2009, 2010, or 2011 for each radar and a set of seven test motion fields including various superpositions of mean winds, constant diurnal tides, constant and variable semidiurnal tides, and superposed GWs having various amplitudes, scales, periods, directions of propagation, momentum fluxes, and intermittencies. Radars having higher power and/or antenna patterns yielding higher meteor counts at small zenith angles perform well in defining monthly and daily mean winds, tidal amplitudes, and GW momentum fluxes, though with expected larger uncertainties in the daily estimates. Conventional radars having lower power and a single transmitting antenna are able to describe monthly mean winds and tidal amplitudes reasonably well, especially at altitudes having the highest meteor counts. They also provide reasonable estimates of GW momentum fluxes at the altitudes having the highest meteor counts; however, these estimates are subject to uncertainties of ˜20 to 50% and uncertainties rapidly become excessive at higher and lower altitudes. Estimates of all quantities degrade somewhat for more complex motion fields.

  3. Assessment of human immediate response capability related to tsunami threats in Indonesia at a sub-national scale

    Science.gov (United States)

    Post, J.; Wegscheider, S.; Mück, M.; Zosseder, K.; Kiefl, R.; Steinmetz, T.; Strunz, G.

    2009-07-01

    Human immediate response is contextualized into different time compartments reflecting the tsunami early warning chain. Based on the different time compartments the available response time and evacuation time is quantified. The latter incorporates accessibility of safe areas determined by a hazard assessment, as well as environmental and demographic impacts on evacuation speed properties assessed using a Cost Distance Weighting GIS approach. Approximately 4.35 million Indonesians live in tsunami endangered areas on the southern coasts of Sumatra, Java and Bali and have between 20 and 150 min to reach a tsunami-safe area. Most endangered areas feature longer estimated-evacuation times and hence the population possesses a weak immediate response capability leaving them more vulnerable to being directly impacted by a tsunami. At a sub-national scale these hotspots were identified and include: the Mentawai islands off the Sumatra coast, various sub-districts on Sumatra and west and east Java. Based on the presented approach a temporal dynamic estimation of casualties and displacements as a function of available response time is obtained for the entire coastal area. As an example, a worst case tsunami scenario for Kuta (Bali) results in casualties of 25 000 with an optimal response time (direct evacuation when receiving a tsunami warning) and 120 000 for minimal response time (no evacuation). The estimated casualties correspond well to observed/reported values and overall model uncertainty is low with a standard error of 5%. The results obtained allow for prioritization of intervention measures such as early warning chain, evacuation and contingency planning, awareness and preparedness strategies down to a sub-district level and can be used in tsunami early warning decision support.

  4. Ecological Capability Assessment for Multiple-Use in Forest Areas Using GIS- Based Multiple Criteria Decision Making Approach

    Directory of Open Access Journals (Sweden)

    Sasan Babaie-Kafaky

    2009-01-01

    Full Text Available Problem statement: A valuable Source of plant and animal various species in the west of Iran is Zagros forests that, misuses by foresters and local societies has caused severe degradation. In this study, forest areas ecological assessment was carried out with a (GIS-based MCDM approach for multiple-use planning in order to reduce degradation and improving sustainability. Approach: All of possible land uses were evaluated separately. The AHP was used to defining weight of criteria and sub-criteria. Sub-criteria were mapped at GIS environment using available data, fieldwork and IRSp6 data. A priority map for each land use was created using GIS-based WLC model. The final priority map was produced of overlying all priority maps. Ecological capability map were generated with editing priority map using present land use map, IRSp6 data, forest laws and fieldwork. Results: The Weights of criteria and sub- criteria was defined for all land uses with CRConclusion: The results of this study showed that various land uses meaning multiple-use can be exist in area study that executing of those will be cause decreasing of foresters dependence to forest trees, decreasing of degradation and forest sustainability. Thus, this integrated approach could be benefit forest planners and decision makers. Recommendation: Through this study, we aimed at suggesting to forest management and other stakeholders an approach that is scientifically sound and practical.

  5. Capability ethics

    NARCIS (Netherlands)

    I.A.M. Robeyns (Ingrid)

    2012-01-01

    textabstractThe capability approach is one of the most recent additions to the landscape of normative theories in ethics and political philosophy. Yet in its present stage of development, the capability approach is not a full-blown normative theory, in contrast to utilitarianism, deontological theor

  6. Dynamic Capabilities

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe; Stenger, Marianne

    2013-01-01

    The findings reveal a positive relationship between dynamic capabilities and innovation performance in the case enterprises, as we would expect. It was, however, not possible to establish a positive relationship between innovation performance and profitability. Nor was there any positive...... relationship between dynamic capabilities and profitability....

  7. The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.

    Science.gov (United States)

    DiMattia, Michael A; Watts, Norman R; Cheng, Naiqian; Huang, Rick; Heymann, J Bernard; Grimes, Jonathan M; Wingfield, Paul T; Stuart, David I; Steven, Alasdair C

    2016-07-01

    HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oligomerizes cooperatively onto an RNA motif, the Rev response element (RRE), forming a complex that engages with the host nuclear export machinery. To better understand Rev oligomerization, we determined four crystal structures of Rev N-terminal domain dimers, which show that they can pivot about their dyad axis, giving crossing angles of 90° to 140°. In parallel, we performed cryoelectron microscopy of helical Rev filaments. Filaments vary from 11 to 15 nm in width, reflecting variations in dimer crossing angle. These structures contain additional density, indicating that C-terminal domains become partially ordered in the context of filaments. This conformational variability may be exploited in the assembly of RRE/Rev complexes. Our data also revealed a third interface between Revs, which offers an explanation for how the arrangement of Rev subunits adapts to the "A"-shaped architecture of the RRE in export-active complexes. PMID:27265851

  8. Assessing Maternal Capabilities in the SHINE Trial: Highlighting a Hidden Link in the Causal Pathway to Child Health.

    Science.gov (United States)

    Matare, Cynthia R; Mbuya, Mduduzi N N; Pelto, Gretel; Dickin, Katherine L; Stoltzfus, Rebecca J

    2015-12-15

    A potential bottleneck for increasing the adoption of child health interventions has been limited attention to designing actions that are built on the essential role that caregivers play in determining their effectiveness. In the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial, we utilize the concept of maternal capabilities to examine participants' skills and attributes that affect their ability to provide appropriate care for their young child, fully engage with trial interventions, and influence the response to these interventions at the household level. We hypothesize that the impact of SHINE interventions on child stunting and anemia will be modified by these maternal capabilities. Drawing upon multiple theories, we identify and define critical maternal capabilities domains, and describe how they are measured in the trial. Description of maternal capabilities and their role as potential modifiers on impact will increase understanding of the impact of SHINE interventions, and the generalizability of our findings. PMID:26602303

  9. Assessing Maternal Capabilities in the SHINE Trial: Highlighting a Hidden Link in the Causal Pathway to Child Health.

    Science.gov (United States)

    Matare, Cynthia R; Mbuya, Mduduzi N N; Pelto, Gretel; Dickin, Katherine L; Stoltzfus, Rebecca J

    2015-12-15

    A potential bottleneck for increasing the adoption of child health interventions has been limited attention to designing actions that are built on the essential role that caregivers play in determining their effectiveness. In the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial, we utilize the concept of maternal capabilities to examine participants' skills and attributes that affect their ability to provide appropriate care for their young child, fully engage with trial interventions, and influence the response to these interventions at the household level. We hypothesize that the impact of SHINE interventions on child stunting and anemia will be modified by these maternal capabilities. Drawing upon multiple theories, we identify and define critical maternal capabilities domains, and describe how they are measured in the trial. Description of maternal capabilities and their role as potential modifiers on impact will increase understanding of the impact of SHINE interventions, and the generalizability of our findings.

  10. Dynamic Capabilities

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe; Stenger, Marianne

    2013-01-01

    The findings reveal a positive relationship between dynamic capabilities and innovation performance in the case enterprises, as we would expect. It was, however, not possible to establish a positive relationship between innovation performance and profitability. Nor was there any positive relation......The findings reveal a positive relationship between dynamic capabilities and innovation performance in the case enterprises, as we would expect. It was, however, not possible to establish a positive relationship between innovation performance and profitability. Nor was there any positive...... relationship between dynamic capabilities and profitability....

  11. Gossiping Capabilities

    DEFF Research Database (Denmark)

    Mogensen, Martin; Frey, Davide; Guerraoui, Rachid;

    declare a high capability in order to augment their perceived quality without contributing accordingly. We evaluate HEAP in the context of a video streaming application on a 236 PlanetLab nodes testbed. Our results shows that HEAP improves the quality of the streaming by 25% over a standard gossip......Gossip-based protocols are now acknowledged as a sound basis to implement collaborative high-bandwidth content dissemination: content location is disseminated through gossip, the actual contents being subsequently pulled. In this paper, we present HEAP, HEterogeneity Aware gossip Protocol, where...... nodes dynamically adjust their contribution to gossip dissemination according to their capabilities. Using a continuous, itself gossip-based, approximation of relative capabilities, HEAP dynamically leverages the most capable nodes by (a) increasing their fanouts (while decreasing by the same proportion...

  12. An Assessment of the Capability of ICT Education in Bicol University Polangui Campus, Polangui, Albay, Philippines: A Determinant to its Sustainability

    Directory of Open Access Journals (Sweden)

    Bernardita B Riñon

    2013-01-01

    Full Text Available The 21st Century poses an urgent need for the integration of ICT in classroom instruction. Education is a lifelong process therefore access to information anytime, anywhere is imperative. We need literates to meet the challenges of illiteracy and poverty and bring about the cost reduction of education,   improve the quality and effectiveness of teaching (wikieducator,n.d.. This paper intends to present the results of an assessment on the capability of ICT education where its sustainability largely depends upon it. Specifically, it aimed to determine the profile of the facilities, faculty readiness in ICT literacy, related researches, budgetary allocation for facilities and linkages with non-government and government agencies likewise the level of capability of ICT education was assessed. Findings revealed that the school has the capability to sustain ICT education. In this study, the researchers arrived at the conclusion that capable and sustainable ICT education would produce ICT literates individuals who would meet the challenges of digital world. Keywords:ICT,Capability,Sustainability, New Literacy, Teachers’ Readiness

  13. Modelling and Assessment of the Capabilities of a Supermarket Refrigeration System for the Provision of Regulating Power

    DEFF Research Database (Denmark)

    O'Connell, Niamh; Madsen, Henrik; Pinson, Pierre;

    This report presents an analysis of the demand response capabilities of a supermarket refrigeration system, with a particular focus on the suitability of this resource for participation in the regulating power market. An ARMAX model of the system is identified from experimental data, and the model...

  14. Integrated Process Capability Analysis

    Institute of Scientific and Technical Information of China (English)

    Chen; H; T; Huang; M; L; Hung; Y; H; Chen; K; S

    2002-01-01

    Process Capability Analysis (PCA) is a powerful too l to assess the ability of a process for manufacturing product that meets specific ations. The larger process capability index implies the higher process yield, a nd the larger process capability index also indicates the lower process expected loss. Chen et al. (2001) has applied indices C pu, C pl, and C pk for evaluating the process capability for a multi-process product wi th smaller-the-better, larger-the-better, and nominal-the-best spec...

  15. Assessment to Capability of Emergency Management of Enterprise Based on AHP%基于AHP的企业应急管理能力评价研究

    Institute of Scientific and Technical Information of China (English)

    佟淑娇; 张培红; 钟茂华; 陈宝智

    2012-01-01

    Firstly, the key elements of emergency management such as precaution, preparedness, response and recovery are introduced. Secondly, the assessment index system for emergency management capability for major accident is built and the basic indexes of each element are confirmed too. Furthermore, based on AHP (analytic hierarchy process), the assessment model for ACEM (assessment to capability of emergency management) is built. And the quantitative computation is applied to the true enterprise and its true capability of emergency management is finally obtained. The study results could be useful to improve the emergency management scientifically, to prevent or control maior accident, and to improve the management capability to major accident of enterprise.%首先介绍了应急管理的四个核心要素即预防、准备、响应和恢复的基本内容;其次建立了企业应急管理能力评价指标体系,确定了每个要素所包含的基本指标,并基于层次分析法(AHP)开发了应急管理能力评价ACEM(assessment to capability of emergency management)模型,从而实现对企业应急管理能力的定量综合评价;最后运用该模型对某化工企业应急管理现状进行了评价,确定了该企业的应急管理能力.研究结果对更加科学地开展应急管理工作,更好地预防和控制重特大事故,提高企业的应急管理能力等具有一定的参考价值.

  16. ENTREPRENEURIAL CAPABILITIES

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard; Nielsen, Thorkild

    2003-01-01

    The aim of this article is to analyse entrepreneurship from an action research perspective. What is entrepreneurship about? Which are the fundamental capabilities and processes of entrepreneurship? To answer these questions the article includes a case study of a Danish entrepreneur and his networks...

  17. Capability approach

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal; Kjeldsen, Christian Christrup

    Lærebogen er den første samlede danske præsentation af den af Amartya Sen og Martha Nussbaum udviklede Capability Approach. Bogen indeholder en præsentation og diskussion af Sen og Nussbaums teoretiske platform. I bogen indgår eksempler fra såvel uddannelse/uddannelsespolitik, pædagogik og omsorg....

  18. Developing Alliance Capabilities

    DEFF Research Database (Denmark)

    Heimeriks, Koen H.; Duysters, Geert; Vanhaverbeke, Wim

    This paper assesses the differential performance effects of learning mechanisms on the development of alliance capabilities. Prior research has suggested that different capability levels could be identified in which specific intra-firm learning mechanisms are used to enhance a firm's alliance...... capability. However, empirical testing in this field is scarce and little is known as to what extent different learning mechanisms are indeed useful in advancing a firm's alliance capability. This paper analyzes to what extent intra-firm learning mechanisms help firms develop their alliance capability....... Differential learning may explain in what way firms yield superior returns from their alliances in comparison to competitors. The empirical results show that different learning mechanisms have different performance effects at different stages of the alliance capability development process. The main lesson from...

  19. Assessment of the dye removal capability of submersed aquatic plants in a laboratory-scale wetland system using anova

    OpenAIRE

    O. Keskinkan; M. Z. Lugal Göksu

    2007-01-01

    The textile dye (Basic Blue 41(BB41)) removal capability of a laboratory-scale wetland system was presented in this study. Twenty glass aquaria were used to establish the wetland. Myriophyllum spicatum and Ceratophyllum demersum were planted in the aquaria and acclimated. After establishing flow conditions, the aquaria were fed with synthetic wastewaters containing BB41. The concentration of the dye was adjusted to 11.0 mg/L in the synthetic wastewater. Hydraulic retention times (HRTs) ranged...

  20. Thermodynamics of Rev-RNA interactions in HIV-1 Rev-RRE assembly.

    Science.gov (United States)

    Jayaraman, Bhargavi; Mavor, David; Gross, John D; Frankel, Alan D

    2015-10-27

    The HIV-1 protein Rev facilitates the nuclear export of intron-containing viral mRNAs by recognizing a structured RNA site, the Rev-response-element (RRE), contained in an intron. Rev assembles as a homo-oligomer on the RRE using its α-helical arginine-rich-motif (ARM) for RNA recognition. One unique feature of this assembly is the repeated use of the ARM from individual Rev subunits to contact distinct parts of the RRE in different binding modes. How the individual interactions differ and how they contribute toward forming a functional complex is poorly understood. Here we examine the thermodynamics of Rev-ARM peptide binding to two sites, RRE stem IIB, the high-affinity site that nucleates Rev assembly, and stem IA, a potential intermediate site during assembly, using NMR spectroscopy and isothermal titration calorimetry (ITC). NMR data indicate that the Rev-IIB complex forms a stable interface, whereas the Rev-IA interface is highly dynamic. ITC studies show that both interactions are enthalpy-driven, with binding to IIB being 20-30 fold tighter than to IA. Salt-dependent decreases in affinity were similar at both sites and predominantly enthalpic in nature, reflecting the roles of electrostatic interactions with arginines. However, the two interactions display strikingly different partitioning between enthalpy and entropy components, correlating well with the NMR observations. Our results illustrate how the variation in binding modes to different RRE target sites may influence the stability or order of Rev-RRE assembly and disassembly, and consequently its function.

  1. Assessment on knowledge network sharing capability of industrial cluster based on dempster-shafer theory of evidence.

    Science.gov (United States)

    Dai, Shengli; Zhang, Hailin

    2014-01-01

    Based on Theory of Evidence and reviewing research papers concerned, a concept model of knowledge sharing network among industrial cluster firms, which can be applied to assess knowledge sharing capacity, has been built. Next, the authors create a set of assessment index systems including twelve subindexes under four principle indexes. In this study, ten experts in the same field were invited to score all the indexes of knowledge sharing capacity concerning one certain industrial cluster. The research result shows relatively high knowledge network sharing capacity among the certain industrial cluster firms. Another conclusion is that the assessment method with Theory of Evidence is feasible to conduct such a research.

  2. Assessment on Knowledge Network Sharing Capability of Industrial Cluster Based on Dempster-Shafer Theory of Evidence

    Directory of Open Access Journals (Sweden)

    Shengli Dai

    2014-01-01

    Full Text Available Based on Theory of Evidence and reviewing research papers concerned, a concept model of knowledge sharing network among industrial cluster firms, which can be applied to assess knowledge sharing capacity, has been built. Next, the authors create a set of assessment index systems including twelve subindexes under four principle indexes. In this study, ten experts in the same field were invited to score all the indexes of knowledge sharing capacity concerning one certain industrial cluster. The research result shows relatively high knowledge network sharing capacity among the certain industrial cluster firms. Another conclusion is that the assessment method with Theory of Evidence is feasible to conduct such a research.

  3. Revised Safety Instruction 4 (IS4 REV.)

    CERN Multimedia

    2006-01-01

    Please note that the revised safety instruction 4 (IS4 REV.) entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can also be obtained from the SC unit secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  4. An Assessment of the Capability of ICT Education in Bicol University Polangui Campus, Polangui, Albay, Philippines: A Determinant to its Sustainability

    OpenAIRE

    Bernardita B Riñon; Nelly B Belchez

    2013-01-01

    The 21st Century poses an urgent need for the integration of ICT in classroom instruction. Education is a lifelong process therefore access to information anytime, anywhere is imperative. We need literates to meet the challenges of illiteracy and poverty and bring about the cost reduction of education,   improve the quality and effectiveness of teaching (wikieducator,n.d.). This paper intends to present the results of an assessment on the capability of ICT education where its sustainability l...

  5. Characterization of a fluoride-resistant bacterium Acinetobacter sp. RH5 towards assessment of its water defluoridation capability

    Science.gov (United States)

    Mukherjee, Shraboni; Yadav, Vaibhav; Mondal, Madhumanti; Banerjee, Soumya; Halder, Gopinath

    2015-12-01

    The present study investigates the defluoridation capability of fluoride-resistant bacteria from contaminated groundwater collected from Asanjola and Madhabpur, West Bengal, India. Seven strains of fluoride-resistant bacteria were isolated employing culture media containing 10-250 mg/L of fluoride to evaluate their ability in reducing fluoride concentration in water. Five isolates exhibited significant amount of reduction in fluoride. Isolate RH5 achieved a maximum fluoride removal of 25.7 % from the media at 30 °C and pH 7 after 8 days of incubation. Based on morphological, physiological characteristics and analysis of 16S rDNA gene sequence, isolate RH5 was identified as Acinetobacter sp. RH5. Growth of RH5 was analysed at a diverse pH range, and it could thrive at pH 5-10. The present investigation revealed that the selective pressure of fluoride results in growth of fluoride-resistant bacteria capable of secreting high-affinity anion-binding compounds. This bacterium played a dominant bioremediative role by concentrating the anions so that they become less available. Hence, the fluoride-resistant bacteria, Acinetobacter sp. RH5, could be used as a promising strain for application in water defluoridation from contaminated sites.

  6. Drought Predictability and Prediction in a Changing Climate: Assessing Current Predictive Knowledge and Capabilities, User Requirements and Research Priorities

    Science.gov (United States)

    Schubert, Siegfried

    2011-01-01

    Drought is fundamentally the result of an extended period of reduced precipitation lasting anywhere from a few weeks to decades and even longer. As such, addressing drought predictability and prediction in a changing climate requires foremost that we make progress on the ability to predict precipitation anomalies on subseasonal and longer time scales. From the perspective of the users of drought forecasts and information, drought is however most directly viewed through its impacts (e.g., on soil moisture, streamflow, crop yields). As such, the question of the predictability of drought must extend to those quantities as well. In order to make progress on these issues, the WCRP drought information group (DIG), with the support of WCRP, the Catalan Institute of Climate Sciences, the La Caixa Foundation, the National Aeronautics and Space Administration, the National Oceanic and Atmospheric Administration, and the National Science Foundation, has organized a workshop to focus on: 1. User requirements for drought prediction information on sub-seasonal to centennial time scales 2. Current understanding of the mechanisms and predictability of drought on sub-seasonal to centennial time scales 3. Current drought prediction/projection capabilities on sub-seasonal to centennial time scales 4. Advancing regional drought prediction capabilities for variables and scales most relevant to user needs on sub-seasonal to centennial time scales. This introductory talk provides an overview of these goals, and outlines the occurrence and mechanisms of drought world-wide.

  7. Assessing Clinical Research Capacity in Vietnam: A Framework for Strengthening Capability for Clinical Trials in Developing Countries.

    Science.gov (United States)

    Kagan, Jonathan; Giang, Dao Duc; Iademarco, Michael F; Phung, Van Tt; Lau, Chuen-Yen; Quang, Nguyen Ngo

    2016-01-01

    Although improving health systems promises important benefits, most developing nations lack the resources to support nationally driven clinical research. Strengthened clinical research capacity can advance national health goals by supporting greater autonomy in aligning research with national priorities. From March through June 2010, we assessed six elements of clinical research capacity in Vietnam: research agenda; clinical investigators and biostatisticians; donors and sponsors; community involvement; scientific, ethical, safety, and quality oversight; and clinical research institutions. Assessments were drawn from interviews with investigators, Ministry of Health staff members, nongovernment organizations, and U.S. Mission staff members, and document review. Observations and recommendations were shared with collaborators. Reassessment in 2015 found growth in the number of clinical trials, improved regulation in human subjects protection and community engagement, and modest advances in research agenda setting. Training and investment in institutions remain challenging. A framework for assessing clinical research capacity can affirm strengths and weaknesses and guide the coordination of capacity-building efforts. PMID:27252559

  8. Can a rapid underwater video approach enhance the benthic assessment capability of the National Coastal Condition Assessmentin the Great Lakes?

    Science.gov (United States)

    In the U.S. National Coastal Condition Assessment (NCCA) field survey in summer 2010, over 400 sites in the nearshore zone of the U.S. Great Lakes were sampled. As a supplement to core NCCA benthic taxonomy and sediment chemistry, underwater video images of the bottom condition ...

  9. Oxygen-enhanced MRI for patients with connective tissue diseases: Comparison with thin-section CT of capability for pulmonary functional and disease severity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ohno, Yoshiharu, E-mail: yosirad@kobe-u.ac.jp [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Nishio, Mizuho [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Koyama, Hisanobu [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Yoshikawa, Takeshi; Matsumoto, Sumiaki [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Seki, Shinichiro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Tsubakimoto, Maho [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nakagami-Gun, Okinawa (Japan); Sugimura, Kazuro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan)

    2014-02-15

    Purpose: To prospectively and directly compare oxygen-enhanced (O{sub 2}-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: Thin-section CT, O{sub 2}-enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O{sub 2}-enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined. Results: MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, CT-assessed disease severity: 13.0 ± 7.4%) and without ILD (MRER: 0.25 ± 0.06, p = 0.0011; CT-assessed disease severity: 1.6 ± 1.6%, p < 0.0001). MRER and CT-assessed disease severity correlated significantly with pulmonary functional parameters and serum KL-6 in all subjects (0.61 ≤ r ≤ 0.79, p < 0.05). Conclusion: O{sub 2}-enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD.

  10. Oxygen-enhanced MRI for patients with connective tissue diseases: Comparison with thin-section CT of capability for pulmonary functional and disease severity assessment

    International Nuclear Information System (INIS)

    Purpose: To prospectively and directly compare oxygen-enhanced (O2-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: Thin-section CT, O2-enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O2-enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined. Results: MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, CT-assessed disease severity: 13.0 ± 7.4%) and without ILD (MRER: 0.25 ± 0.06, p = 0.0011; CT-assessed disease severity: 1.6 ± 1.6%, p < 0.0001). MRER and CT-assessed disease severity correlated significantly with pulmonary functional parameters and serum KL-6 in all subjects (0.61 ≤ r ≤ 0.79, p < 0.05). Conclusion: O2-enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD

  11. Assessment of capabilities and research needs in the area of health effects of low-level ionizing radiation. A joint report to the Congress

    International Nuclear Information System (INIS)

    The report summarizes the capabilities, research needs and on-going projects of the Environmental Protection Agency and the Nuclear Regulatory Commission related to the health effects of low-level ionizing radiation. The statutory authorities of both EPA and NRC related to radiation protection and radiation research are also briefly described. An introductory general section describes current efforts to improve Federal radiation research and general methods used by both agencies for radiation dose assessment and the estimation of the potential health effects of low-level ionizing radiation. Separate sections describe the respective authorities, needs, capabilities, and current research programs of the two agencies. The report was prepared to fulfill a requirement by the US Congress which is contained in Section 5(c) of Public Law 95-601

  12. Using pliers in assembly work: short and long task duration effects of gloves on hand performance capabilities and subjective assessments of discomfort and ease of tool manipulation.

    Science.gov (United States)

    Dianat, Iman; Haslegrave, Christine M; Stedmon, Alex W

    2012-03-01

    The present study investigated the effects of wearing typical industrial gloves on hand performance capabilities (muscle activity, wrist posture, touch sensitivity, hand grip and forearm torque strength) and subjective assessments for an extended duration of performing a common assembly task, wire tying with pliers, which requires a combination of manipulation and force exertion. Three commercially available gloves (cotton, nylon and nitrile gloves) were tested and compared with a bare hand condition while participants performed the simulated assembly task for 2 h. The results showed that wearing gloves significantly increased the muscle activity, wrist deviation, and discomfort whilst reducing hand grip strength, forearm torque strength and touch sensitivity. The combined results showed that the length of time for which gloves are worn does affect hand performance capability and that gloves need to be evaluated in a realistic working context. The results are discussed in terms of selection of gloves for industrial assembly tasks involving pliers.

  13. Subsurface flow and transport of organic chemicals: an assessment of current modeling capability and priority directions for future research (1987-1995)

    Energy Technology Data Exchange (ETDEWEB)

    Streile, G.P.; Simmons, C.S.

    1986-09-01

    Theoretical and computer modeling capability for assessing the subsurface movement and fate of organic contaminants in groundwater was examined. Hence, this study is particularly concerned with energy-related, organic compounds that could enter a subsurface environment and move as components of a liquid phase separate from groundwater. The migration of organic chemicals that exist in an aqueous dissolved state is certainly a part of this more general scenario. However, modeling of the transport of chemicals in aqueous solution has already been the subject of several reviews. Hence, this study emphasizes the multiphase scenario. This study was initiated to focus on the important physicochemical processes that control the behavior of organic substances in groundwater systems, to evaluate the theory describing these processes, and to search for and evaluate computer codes that implement models that correctly conceptualize the problem situation. This study is not a code inventory, and no effort was made to identify every available code capable of representing a particular process.

  14. Revised Safety Instruction 41 (IS41 REV.)

    CERN Document Server

    SC Secretariat

    2005-01-01

    Please note that the Revised Safety Instruction No. 41 (IS41 REV.), entitled 'The use of plastic and other non-metallic materials at CERN with respect to fire safety and radiation resistance' is available on the web at the following url: https://edms.cern.ch/document/335806/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  15. Using a Simple Binomial Model to Assess Improvement in Predictive Capability: Sequential Bayesian Inference, Hypothesis Testing, and Power Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Sigeti, David E. [Los Alamos National Laboratory; Pelak, Robert A. [Los Alamos National Laboratory

    2012-09-11

    We present a Bayesian statistical methodology for identifying improvement in predictive simulations, including an analysis of the number of (presumably expensive) simulations that will need to be made in order to establish with a given level of confidence that an improvement has been observed. Our analysis assumes the ability to predict (or postdict) the same experiments with legacy and new simulation codes and uses a simple binomial model for the probability, {theta}, that, in an experiment chosen at random, the new code will provide a better prediction than the old. This model makes it possible to do statistical analysis with an absolute minimum of assumptions about the statistics of the quantities involved, at the price of discarding some potentially important information in the data. In particular, the analysis depends only on whether or not the new code predicts better than the old in any given experiment, and not on the magnitude of the improvement. We show how the posterior distribution for {theta} may be used, in a kind of Bayesian hypothesis testing, both to decide if an improvement has been observed and to quantify our confidence in that decision. We quantify the predictive probability that should be assigned, prior to taking any data, to the possibility of achieving a given level of confidence, as a function of sample size. We show how this predictive probability depends on the true value of {theta} and, in particular, how there will always be a region around {theta} = 1/2 where it is highly improbable that we will be able to identify an improvement in predictive capability, although the width of this region will shrink to zero as the sample size goes to infinity. We show how the posterior standard deviation may be used, as a kind of 'plan B metric' in the case that the analysis shows that {theta} is close to 1/2 and argue that such a plan B should generally be part of hypothesis testing. All the analysis presented in the paper is done with a

  16. Assessing thermochromatography as a separation method for nuclear forensics. Current capability vis-a-vis forensic requirements

    International Nuclear Information System (INIS)

    Nuclear forensic science has become increasingly important for global nuclear security. However, many current laboratory analysis techniques are based on methods developed without the imperative for timely analysis that underlies the post-detonation forensics mission requirements. Current analysis of actinides, fission products, and fuel-specific materials requires time-consuming chemical separation coupled with nuclear counting or mass spectrometry. High-temperature gas-phase separations have been used in the past for the rapid separation of newly created elements/isotopes and as a basis for chemical classification of that element. We are assessing the utility of this method for rapid separation in the gas-phase to accelerate the separations of radioisotopes germane to post-detonation nuclear forensic investigations. The existing state of the art for thermo chromatographic separations, and its applicability to nuclear forensics, will be reviewed. (author)

  17. Novel super-resolution capable mitochondrial probe, MitoRed AIE, enables assessment of real-time molecular mitochondrial dynamics

    Science.gov (United States)

    Lo, Camden Yeung-Wah; Chen, Sijie; Creed, Sarah Jayne; Kang, Miaomiao; Zhao, Na; Tang, Ben Zhong; Elgass, Kirstin Diana

    2016-01-01

    Mitochondria and mitochondrial dynamics play vital roles in health and disease. With the intricate nanometer-scale structure and rapid dynamics of mitochondria, super-resolution microscopy techniques possess great un-tapped potential to significantly contribute to understanding mitochondrial biology and kinetics. Here we present a novel mitochondrial probe (MitoRed AIE) suitable for live mitochondrial dynamics imaging and single particle tracking (SPT), together with a multi-dimensional data analysis approach to assess local mitochondrial (membrane) fluidity. The MitoRed AIE probe localizes primarily to mitochondrial membranes, with 95 ms fluorophore on-time delivering 106 photons/ms, characteristics which we exploit to demonstrate live cell 100 fps 3D time-lapse tracking of mitochondria. Combining our experimental and analytical approaches, we uncover mitochondrial dynamics at unprecedented time scales. This approach opens up a new regime into high spatio-temporal resolution dynamics in many areas of mitochondrial biology. PMID:27492961

  18. The InSAeS4 Airborne X-Band Interferometric SAR System: A First Assessment on Its Imaging and Topographic Mapping Capabilities

    OpenAIRE

    Stefano Perna; Carmen Esposito; Tiago Amaral; Paolo Berardino; Giuseppe Jackson; João Moreira; Antonio Pauciullo; Eurico Vaz Junior; Christian Wimmer; Riccardo Lanari

    2016-01-01

    We present in this work a first assessment of the imaging and topographic mapping capabilities of the InSAeS4 system, which is a single-pass interferometric airborne X-Band Synthetic Aperture Radar (SAR). In particular, we first provide a brief description of the InSAeS4 sensor. Then, we discuss the results of our analysis on the SAR and interferometric SAR products relevant to the first flight-test campaign. More specifically, we have exploited as reference the GPS measurements relevant to n...

  19. Assessment of capabilities of multiangle imaging photo-polarimetry for atmospheric correction in presence of absorbing aerosols

    Science.gov (United States)

    Kalashnikova, O. V.; Garay, M. J.; Xu, F.; Seidel, F. C.; Diner, D. J.

    2015-12-01

    Satellite remote sensing of ocean color is a critical tool for assessing the productivity of marine ecosystems and monitoring changes resulting from climatic or environmental influences. Yet water-leaving radiance comprises less than 10% of the signal measured from space, making correction for absorption and scattering by the intervening atmosphere imperative. Traditional ocean color retrieval algorithms utilize a standard set of aerosol models and the assumption of negligible water-leaving radiance in the near-infrared. Modern improvements have been developed to handle absorbing aerosols such as urban particulates in coastal areas and transported desert dust over the open ocean, where ocean fertilization can impact biological productivity at the base of the marine food chain. Even so, imperfect knowledge of the absorbing aerosol optical properties or their height distribution results in well-documented sources of error. In the UV, the problem of UV-enhanced absorption and nonsphericity of certain aerosol types are amplified due to the increased Rayleigh and aerosol optical depth, especially at off-nadir view angles. Multi-angle spectro-polarimetric measurements have been advocated as an additional tool to better understand and retrieve the aerosol properties needed for atmospheric correction for ocean color retrievals. The central concern of the work to be described is the assessment of the effects of absorbing aerosol properties on water leaving radiance measurement uncertainty by neglecting UV-enhanced absorption of carbonaceous particles and by not accounting for dust nonsphericity. In addition, we evaluate the polarimetric sensitivity of absorbing aerosol properties in light of measurement uncertainties achievable for the next generation of multi-angle polarimetric imaging instruments, and demonstrate advantages and disadvantages of wavelength selection in the UV/VNIR range. The phase matrices for the spherical smoke particles were calculated using a standard

  20. Assessing recall, conceptualization, and transfer capabilities of novice biochemistry students' across learning style preferences as revealed by self-explanations

    Science.gov (United States)

    Hilsenbeck-Fajardo, Jacqueline L.

    2009-08-01

    The research described herein is a multi-dimensional attempt to measure student's abilities to recall, conceptualize, and transfer fundamental and dynamic protein structure concepts as revealed by their own diagrammatic (pictorial) representations and written self-explanations. A total of 120 participants enrolled in a 'Fundamentals of Biochemistry' course contributed to this mixed-methodological study. The population of interest consisted primarily of pre-nursing and sport and exercise science majors. This course is typically associated with a high (protein denaturation. When knowledge transfer was carefully assessed within the predefined context, numerous misconceptions pertaining to the fundamental and dynamic nature of protein structure were revealed. Misconceptions tended to increase as the transfer model shifted away from the context presented in the original learning material. Ultimately, a fundamentally new, novel, and unique measure of knowledge transfer was developed as a main result of this study. It is envisioned by the researcher that this new measure of learning is applicable specifically to physical and chemical science education-based research in the form of deep transfer on the atomic-level scale.

  1. An Assessment of the Capabilities of the ERS Satellites' Active Microwave Instruments for Monitoring Soil Moisture Change

    Directory of Open Access Journals (Sweden)

    K. Blyth

    1997-01-01

    Full Text Available The launch of the European Remote sensing Satellite (ERS-1 in July 1991 represented an important turning point in the development of Earth observation as it was the first of a series of satellites which would carry high resolution active microwave (radar sensors which could operate through the thickest cloudeover and provide continuity of data for at least a decade. This was of particular relevance to hydrological applications, such as soil moisture monitoring, which generally require frequent satellite observations to monitor changes in state. ERS-1 and its successor ERS-2 carry the active microwave instrument (AMI which operates in 3 modes (synthetic aperture radar, wind scatterometer and wave seatterometer together with the radar altimeter which may all be useful for the observation of soil moisture. This paper assesses the utility of these sensors through a comprehensive review of work in this field. Two approaches to soil moisture retrieval are identified: 1 inversion modelling, where the physical effects of vegetation and soil roughness on radar backscatter are quantified through the use of multi-frequency and/or multi-polarization sensors and 2 change detection where these effects are normalized through frequent satellite observation, the residual effects being attributed to short-term changes in soil moisture. Both approaches will be better supported by the future European Envisat-l satellite which will provide both multi-polarization SAR and low resolution products which should facilitate more frequent temporal observation.

  2. A nucleolar localizing Rev binding element inhibits HIV replication

    Directory of Open Access Journals (Sweden)

    Bozzoni Irene

    2006-05-01

    Full Text Available Abstract The Rev protein of the human immunodeficiency virus (HIV facilitates the nuclear export of intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through the nucleolus and shuttles between the nucleus and cytoplasm. Rev multimerization and interaction with the export protein CRM1 takes place in the nucleolus. To test the importance of Rev nucleolar trafficking in the HIV-1 replication cycle, we created a nucleolar localizing Rev Response Element (RRE decoy and tested this for its anti-HIV activity. The RRE decoy provided marked inhibition of HIV-1 replication in both the CEM T-cell line and in primary CD34+ derived monocytes. These results demonstrate that titration of Rev in the nucleolus impairs HIV-1 replication and supports a functional role for Rev trafficking in this sub-cellular compartment.

  3. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

    2005-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  4. Suppression of atherosclerosis by synthetic REV-ERB agonist

    Energy Technology Data Exchange (ETDEWEB)

    Sitaula, Sadichha [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Billon, Cyrielle [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States); Kamenecka, Theodore M.; Solt, Laura A. [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Burris, Thomas P., E-mail: burristp@slu.edu [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States)

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  5. Suppression of atherosclerosis by synthetic REV-ERB agonist

    International Nuclear Information System (INIS)

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization

  6. Capability Handbook- offline metrology

    DEFF Research Database (Denmark)

    Islam, Aminul; Marhöfer, David Maximilian; Tosello, Guido;

    This offline metrological capability handbook has been made in relation to HiMicro Task 3.3. The purpose of this document is to assess the metrological capability of the HiMicro partners and to gather the information of all available metrological instruments in the one single document. It provides...... a quick overview of what is possible today by the state of the art, what the HiMicro consortium can do and what metrological requirements we have concerning the HiMicro industrial demonstrators....

  7. Altered sleep homeostasis in rev-erbα knockout mice

    OpenAIRE

    Mang, Géraldine M.; La Spada, Francesco; Emmenegger, Yann; Chappuis, Sylvie; Ripperger, Jürgen A; Albrecht, Urs; Franken, Paul

    2016-01-01

    Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including Rev-erbα, is modulated by sleep loss. We here test the consequen...

  8. Non-small cell carcinoma: Comparison of postoperative intra- and extrathoracic recurrence assessment capability of qualitatively and/or quantitatively assessed FDG-PET/CT and standard radiological examinations

    Energy Technology Data Exchange (ETDEWEB)

    Onishi, Yumiko, E-mail: onitan@med.kobe-u.ac.jp [Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo (Japan); Ohno, Yoshiharu, E-mail: yosirad@kobe-u.ac.jp [Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo (Japan); Koyama, Hisanobu; Nogami, Munenobu; Takenaka, Daisuke [Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo (Japan); Matsumoto, Keiko [Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo (Japan); Department of Radiology, Yamanashi University, Shimokato, Yamanashi (Japan); Yoshikawa, Takeshi; Matsumoto, Sumiaki [Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo (Japan); Maniwa, Yoshimasa [Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Nishimura, Yoshihiro [Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Sugimura, Kazuro [Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo (Japan)

    2011-09-15

    Purpose: The purpose of this study was to compare the capability of integrated FDG-PET/CT for assessment of postoperative intra- and extrathoracic recurrence in non-small cell lung cancer (NSCLC) patients with that of standard radiological examinations. Materials and methods: A total of 121 consecutive pathologically diagnosed NSCLC patients (80 males, 41 females; mean age, 71 years) underwent pathologically and surgically confirmed complete resection, followed by prospective integrated FDG-PET/CT and standard radiological examinations. Final diagnosis of recurrence was based on the results of more than 12 months of follow-up and/or pathological examinations. The probability of recurrence was assessed with either method for each patient by using 5-point visual scoring system, and final diagnosis was made by consensus between two readers. ROC analysis was used to compare the capability of the two methods for assessment of postoperative recurrence on a per-patient basis. The ROC-based positive test was used to determine optimal cut-off value for FDG uptake measurement at a site suspected on the basis of qualitatively assessed PET/CT. Finally, sensitivities, specificities and accuracies of all methods were compared by means of McNemar's test. Results: Areas under the curve of qualitatively assessed PET/CT and standard radiological examinations showed no significant differences (p > 0.05). At an optimal cut-off value of 2.5, specificity and accuracy of quantitatively and qualitatively assessed PET/CT were significantly higher than those of qualitatively assessed PET/CT and standard radiological examinations (p < 0.05). Conclusion: Accuracy of assessment of postoperative intra- and extrathoracic recurrence in NSCLC patients by qualitative and/or quantitative FDG-PET/CT is equivalent to or higher than that by standard radiological examinations.

  9. Evaluation of swimming capability and potential velocity barrier problems for fish. Part B: New telemetric approaches to the assessment of fish swimming performance

    International Nuclear Information System (INIS)

    This report represents the second part of a study undertaken to develop information related to swimming capability of several important fish species. The study will provide biological design criteria to mitigate potential velocity barrier problems associated with hydroelectric power plants. This part of the report focuses on the development and evaluation of approaches to assessing locomotory activity, swimming performance and energy load costs to fish under naturally occurring conditions and in relation to potential barriers. The study involved implantation of a bio-sensitive radio transmitter (electromyogram (EMG)) tag in the swimming muscle of fish, calibration of locomotory ability and energetic scope, and subsequent use of EMG signals to assess swimming performance and metabolic costs in situ. Digital signal processing (DSP) with antennae switching was also used to study high speed swimming performance, behaviour, and migratory strategy in relation to ascent of an experimental flume. The techniques and technologies developed indicate the complexity of factors that regulate fish swimming energy expenditure that need to be considered in the design and operation of fish passage facilities. 84 refs., 6 tabs., figs., 2 appendices

  10. Present status of the 'CIAU' (Code with capability of Internal Assessment of Uncertainty) and application possibilities in the licensing process

    Energy Technology Data Exchange (ETDEWEB)

    D' Auria, F.; Giannotti, W. [Pisa Univ. (Italy). Dipt. di Ingegneria Meccanica, Nucleare e della Produzione. E-mail: dauria@ing.unipi.it

    2000-07-01

    The internal assessment constitutes a desirable capacity for thermalhydraulic system codes allowing the achievement of uncertainty bands associated with any code-calculation result. Currently, the CIAU (Code with - the capability of - Internal Assessment of Uncertainty) is derived from the UMAE (Uncertainty Methodology based on the Accuracy Extrapolation), through other uncertainty methodologies can be used for the same purpose. Therefore, the system code, Relap5 in the present case, is coupled with the uncertainty methodology and constitutes the CIAU. The idea at the basis of CIAU is the identification and the characterization of standard plant statuses and the association of uncertainty to each status. One hypercube and one time interval identify the plant status. Quantity and Time uncertainties are combined for each plant status. In the present paper, the derivation of the methodology is outlined and typical results of PWR (Pressurized Water reactor) plant transients are shown bounded by the CIAU calculated uncertainty bands. Results of a bifurcation study are shown and the possibility of integrating the methodology within the licensing process is discussed. (author)

  11. Identification of a novel Rev-interacting cellular protein

    Directory of Open Access Journals (Sweden)

    Werner Thomas

    2005-04-01

    Full Text Available Abstract Background Human cell types respond differently to infection by human immunodeficiency virus (HIV. Defining specific interactions between host cells and viral proteins is essential in understanding how viruses exploit cellular functions and the innate strategies underlying cellular control of HIV replication. The HIV Rev protein is a post-transcriptional inducer of HIV gene expression and an important target for interaction with cellular proteins. Identification of Rev-modulating cellular factors may eventually contribute to the design of novel antiviral therapies. Results Yeast-two hybrid screening of a T-cell cDNA library with Rev as bait led to isolation of a novel human cDNA product (16.4.1. 16.4.1-containing fusion proteins showed predominant cytoplasmic localization, which was dependent on CRM1-mediated export from the nucleus. Nuclear export activity of 16.4.1 was mapped to a 60 amino acid region and a novel transport signal identified. Interaction of 16.4.1 with Rev in human cells was shown in a mammalian two-hybrid assay and by colocalization of Rev and 16.4.1 in nucleoli, indicating that Rev can recruit 16.4.1 to the nucleus/nucleoli. Rev-dependent reporter expression was inhibited by overexpressing 16.4.1 and stimulated by siRNAs targeted to 16.4.1 sequences, demonstrating that 16.4.1 expression influences the transactivation function of Rev. Conclusion These results suggest that 16.4.1 may act as a modulator of Rev activity. The experimental strategies outlined in this study are applicable to the identification and biological characterization of further novel Rev-interacting cellular factors.

  12. Building Service Provider Capabilities

    DEFF Research Database (Denmark)

    Brandl, Kristin; Jaura, Manya; Ørberg Jensen, Peter D.

    process. We find that clients influence the development of human capital capabilities and management capabilities in reciprocally produced services. While in sequential produced services clients influence the development of organizational capital capabilities and management capital capabilities....

  13. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function

    DEFF Research Database (Denmark)

    Bugge, Anne Skovsø; Feng, Dan; Everett, Logan J;

    2012-01-01

    of binding sites across the genome, enriched near metabolic genes. Depletion of both Rev-erbs in liver synergistically derepresses several metabolic genes as well as genes that control the positive limb of the molecular clock. Moreover, deficiency of both Rev-erbs causes marked hepatic steatosis, in contrast...

  14. Capitalizing on capabilities.

    Science.gov (United States)

    Ulrich, Dave; Smallwood, Norm

    2004-06-01

    By making the most of organizational capabilities--employees' collective skills and fields of expertise--you can dramatically improve your company's market value. Although there is no magic list of proficiencies that every organization needs in order to succeed, the authors identify 11 intangible assets that well-managed companies tend to have: talent, speed, shared mind-set and coherent brand identity, accountability, collaboration, learning, leadership, customer connectivity, strategic unity, innovation, and efficiency. Such companies typically excel in only three of these capabilities while maintaining industry parity in the other areas. Organizations that fall below the norm in any of the 11 are likely candidates for dysfunction and competitive disadvantage. So you can determine how your company fares in these categories (or others, if the generic list doesn't suit your needs), the authors explain how to conduct a "capabilities audit," describing in particular the experiences and findings of two companies that recently performed such audits. In addition to highlighting which intangible assets are most important given the organization's history and strategy, this exercise will gauge how well your company delivers on its capabilities and will guide you in developing an action plan for improvement. A capabilities audit can work for an entire organization, a business unit, or a region--indeed, for any part of a company that has a strategy to generate financial or customer-related results. It enables executives to assess overall company strengths and weaknesses, senior leaders to define strategy, midlevel managers to execute strategy, and frontline leaders to achieve tactical results. In short, it helps turn intangible assets into concrete strengths. PMID:15202293

  15. ASSESSMENT OF THE DYNAMIC OF PHYSICAL CAPABILITY IN PATIENTS AFTER ORTHOTOPIC HEART TRANSPLANTATION ACCORDING TO BICYCLE ERGOMETRY TEST IN DIFFERENT TERMS AFTER THE OPERATION

    Directory of Open Access Journals (Sweden)

    O. A. Sudzaeva

    2013-01-01

    Full Text Available Aim. To evaluate dynamic of physical capability (PC based on bicycle ergometry test data in different post- operation terms after orthotopic heart transplantation (OHT. Methods and results. In 28 patients aged from 19 to 59 (mean 45,9 ± 2,2 years the dynamics of PC values was assessed at 14–36 (mean 20,8 ± 1,6 months after OHT. Prior to surgery, all 28 patients had low exercise tolerance (ET as well as low maximal oxygen consump- tion (VO2max. A significant increase in ET and VO2max was registered in 6 and 12 months after OHT compared to baseline (р < 0,05, a trend to increasing PC values was noted in 6 to 12 months after OHT compared to baseline, 3 (20% of 15 patients examined showed myocardial ischemia. Conclusion. The PC decrease revealed in 14–36 months after OHT may be indicative of vasculopathy development or progressive underlying athero- sclerotic process. 

  16. The InSAeS4 Airborne X-Band Interferometric SAR System: A First Assessment on Its Imaging and Topographic Mapping Capabilities

    Directory of Open Access Journals (Sweden)

    Stefano Perna

    2016-01-01

    Full Text Available We present in this work a first assessment of the imaging and topographic mapping capabilities of the InSAeS4 system, which is a single-pass interferometric airborne X-Band Synthetic Aperture Radar (SAR. In particular, we first provide a brief description of the InSAeS4 sensor. Then, we discuss the results of our analysis on the SAR and interferometric SAR products relevant to the first flight-test campaign. More specifically, we have exploited as reference the GPS measurements relevant to nine Corner Reflectors (CRs deployed over the illuminated area during the campaign and a laser scanner Digital Elevation Model (DEM. From the analysis carried out on the CRs we achieved a mean geometric resolution, for the SAR products, of about 0.14 m in azimuth and 0.49 m in range, a positioning misalignment with standard deviation of 0.07 m in range and 0.08 m in azimuth, and a height error with standard deviation of 0.51 m. From the comparison with the laser scanner DEM we estimated a height error with standard deviation of 1.57 m.

  17. Administrative Circular No. 14 (Rev. 2)

    CERN Multimedia

    HR Department

    2007-01-01

    The HR Department wishes to draw the attention of members of the personnel to a number of amendments to Administrative Circular No. 14 (Rev. 2) entitled "Protection of members of the personnel against the financial consequences of illness, accident and disability" which came into force on 1st July 2006 (cf. Weekly Bulletin of 14 and 21 August 2006). Occupational Accident Declaration Form (HS50) https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under ...

  18. Pärnu REV sai kuuekümneseks / Andres Mets

    Index Scriptorium Estoniae

    Mets, Andres, 1943-

    2004-01-01

    Ehitusfirma Pärnu REV tähistab ainsa toimiva ja sisu muutnud remondi- ja ehitusvalitsusena kuuekümneaastast juubelit. Kommenteerivad REV-i nõukogu esimees Raivo Pulk ja REV-i juhataja Uno Kõressaar

  19. The United States’ Assessment and Countermeasures to China’ s Cyberwarfare Capabilities%美国对中国网络战能力的评估与对策

    Institute of Scientific and Technical Information of China (English)

    汪婧

    2015-01-01

    In recent years, based on the consideration of national interests and ideology, the United States is increasingly concerning about China’ s cyberwarfare capabilities. Based on an assessment of Chi⁃na’s cyberwarfare capabilities, the United States believes that China is likely to use the increasing ability of information technology to launch cyber warfare to the United States, so it must not only strengthen net⁃work defense and look for partners, but also build international network space order, integrate make poli⁃cy and security defense network as well as to strengthen network ability to deter or beat the enemy. The U.S. cyber security policy toward China is full of ideological bias and cold war thinking in that it lacks strategic mutual trust with China on network security and tries to dominate the network space order to en⁃sure network space supremacy.%近年来,基于国家利益和意识形态的考虑,美国对中国网络战能力的担忧与日俱增。根据对中国网络战能力的评估,美国认为中国可能正利用日益增强的信息技术能力对美发起网络战,对此必须加强对中国的网络防御,寻找网络安全合作伙伴,构建国际网络空间秩序,使网络政策和安全防御一体化,加强网络威慑或击败敌手的能力。美国对华网络空间安全政策充满意识形态偏见和冷战思维,与中国缺乏网络安全战略互信,试图主导网络空间秩序和确保美国网络空间霸权,对中美关系与世界和平造成了危害,因此当务之急是中美建立网络安全战略互信关系及机制,并积极应对两国间出现的网络安全问题。

  20. Group Capability Model

    Science.gov (United States)

    Olejarski, Michael; Appleton, Amy; Deltorchio, Stephen

    2009-01-01

    The Group Capability Model (GCM) is a software tool that allows an organization, from first line management to senior executive, to monitor and track the health (capability) of various groups in performing their contractual obligations. GCM calculates a Group Capability Index (GCI) by comparing actual head counts, certifications, and/or skills within a group. The model can also be used to simulate the effects of employee usage, training, and attrition on the GCI. A universal tool and common method was required due to the high risk of losing skills necessary to complete the Space Shuttle Program and meet the needs of the Constellation Program. During this transition from one space vehicle to another, the uncertainty among the critical skilled workforce is high and attrition has the potential to be unmanageable. GCM allows managers to establish requirements for their group in the form of head counts, certification requirements, or skills requirements. GCM then calculates a Group Capability Index (GCI), where a score of 1 indicates that the group is at the appropriate level; anything less than 1 indicates a potential for improvement. This shows the health of a group, both currently and over time. GCM accepts as input head count, certification needs, critical needs, competency needs, and competency critical needs. In addition, team members are categorized by years of experience, percentage of contribution, ex-members and their skills, availability, function, and in-work requirements. Outputs are several reports, including actual vs. required head count, actual vs. required certificates, CGI change over time (by month), and more. The program stores historical data for summary and historical reporting, which is done via an Excel spreadsheet that is color-coded to show health statistics at a glance. GCM has provided the Shuttle Ground Processing team with a quantifiable, repeatable approach to assessing and managing the skills in their organization. They now have a common

  1. On the capability of Swarm for surface mass variation monitoring: Quantitative assessment based on orbit information from CHAMP, GRACE and GOCE

    Science.gov (United States)

    Baur, Oliver; Weigelt, Matthias; Zehentner, Norbert; Mayer-Gürr, Torsten; Jäggi, Adrian

    2014-05-01

    In the last decade, temporal variations of the gravity field from GRACE observations have become one of the most ubiquitous and valuable sources of information for geophysical and environmental studies. In the context of global climate change, mass balance of the Arctic and Antarctic ice sheets gained particular attention. Because GRACE has outlived its predicted lifetime by several years already, it is very likely that a gap between GRACE and its successor GRACE follow-on (supposed to be launched in 2017, at the earliest) occurs. The Swarm mission - launched on November 22, 2013 - is the most promising candidate to bridge this potential gap, i.e., to directly acquire large-scale mass variation information on the Earth's surface in case of a gap between the present GRACE and the upcoming GRACE follow-on projects. Although the magnetometry mission Swarm has not been designed for gravity field purposes, its three satellites have the characteristics for such an endeavor: (i) low, near-circular and near-polar orbits, (ii) precise positioning with high-quality GNSS receivers, (iii) on-board accelerometers to measure the influence of non-gravitational forces. Hence, from an orbit analysis point of view the Swarm satellites are comparable to the CHAMP, GRACE and GOCE spacecraft. Indeed and as data analysis from CHAMP has been shown, the detection of annual signals and trends from orbit analysis is possible for long-wavelength features of the gravity field, although the accuracy associated with the inter-satellite GRACE measurements cannot be reached. We assess the capability of the (non-dedicated) mission Swarm for mass variation detection in a real-case environment (opposed to simulation studies). For this purpose, we "approximate" the Swarm scenario by the GRACE+CHAMP and GRACE+GOCE constellations. In a first step, kinematic orbits of the individual satellites are derived from GNSS observations. From these orbits, we compute monthly combined GRACE+CHAMP and GRACE

  2. Residential Parking Spaces Shared Capability Assessment Model%居住区泊位对外共享能力评估模型

    Institute of Scientific and Technical Information of China (English)

    段满珍; 杨兆升; 张林; 于德新

    2015-01-01

    Considering from the ideology of parking resources sharing, the residential parking spaces shared service capability assessment model is researched. First, the basic conditions of sharing parking are analyzed, then the available characteristics of parking spaces are analyzed. On this basis, a sharing parking service capacity assessment model is proposed, model parameter values and distribution rules are studied by the statistical analysis method. Statistical result shows that, the average time of the adjacent vehicles in and out of the parking space is about 62.6 seconds. The parking data fitted results show that residential areas parking space available time obey Negative Exponential Distribution, parking time of the sharing vehicle obey Gamma Distribution. In order to guarantee the practicability of the model, this paper provides reference data for available parking state parameters, shape and scale parameter values of the Gamma Distribution. The example result shows that the residential sharing parking can provide about 55%residential parking spaces resources for its adjacent buildings.%从停车资源共享理念出发,研究居住区泊位对外共享服务能力评估模型.首先分析了实施停车泊位共享的基本条件,然后分析了居住区的泊位空闲特性,在此基础上构建了停车泊位共享服务能力评估模型,并应用统计学方法对模型参数的取值、分布规律进行了拟合分析.统计结果表明,相邻两车进出泊位平均用时为62.6 s.数据拟合结果表明,居住区泊位空闲时间服从负指数分布,共享车辆停放时间服从Gamma分布.为保证模型实用性,给出了泊位状态参数.Gamma分布形状参数、标度参数的参考数据.算例估算结果表明:居住区停车泊位共享能够为毗邻建筑提供相当于居住区泊位55%左右的停车泊位资源.

  3. Administrative Circular N° 26 (Rev.  5) - November 2004

    CERN Multimedia

    Human Resources Department

    2004-01-01

    Procedure governing the career evolution of staff members The introduction of an electronic individual appraisal report form via EDH for the MAPS exercise entails some modifications to Administrative Circular N° 26 (Rev. 4). The revised version (Rev. 5) is available in departmental secretariats as well as on the Web at the following address: http://cern.ch/hr-web/internal/admin_services/admincirc/listadmincirc.asp Human Resources Department Tel. 74128

  4. Analysis and evaluation of enterprise risk management capability elements

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Research on enterprise risk management capability is conducted with a view of discerning and processing risks, in which an evaluation index system and an evaluation model of enterprise risk management capabilities are constructed. The risk management capability consists of four aspects, i.e. risk identification capability, risk assessment capability, risk planning capability and risk control capability. Risk identification and assessment capabilities reflect the level of enterprises on finding and analyzing...

  5. Mobile Test Capabilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Electrical Power Mobile Test capabilities are utilized to conduct electrical power quality testing on aircraft and helicopters. This capability allows that the...

  6. Earth Science Capability Demonstration Project

    Science.gov (United States)

    Cobleigh, Brent

    2006-01-01

    A viewgraph presentation reviewing the Earth Science Capability Demonstration Project is shown. The contents include: 1) ESCD Project; 2) Available Flight Assets; 3) Ikhana Procurement; 4) GCS Layout; 5) Baseline Predator B Architecture; 6) Ikhana Architecture; 7) UAV Capability Assessment; 8) The Big Picture; 9) NASA/NOAA UAV Demo (5/05 to 9/05); 10) NASA/USFS Western States Fire Mission (8/06); and 11) Suborbital Telepresence.

  7. Knowledge Management Capabilities Rubrics

    Directory of Open Access Journals (Sweden)

    Azizah B.A. Rahman

    2011-01-01

    Full Text Available Problem statement: Recently researchers discerned the vitality and importance of Knowledge Management Capabilities (KMC evaluation in organizations. In fact evaluation of KMC helps to prevent failure in Knowledge Management (KM projects. Approach: One of the most popular methods in the phase of evaluating KMC is Fuzzy method which evaluates seven attributes of KMC. Fuzzy needs KM experts to give their opinion about these attributes as input data. However in some organizations these experts are not available. Results: Therefore in this study a rubric matrix is developed as an assessment tool with ordered rank (very high, medium and very low of descriptive characteristics of criteria (seven attributes that organizations wish to evaluate. Conclusion: This rubric is applicable for members of an organization which are not familiar completely with KMC and also will be maintained by analyzing and surveying many different researches.

  8. Accelerator and electrodynamics capability review

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Kevin W [Los Alamos National Laboratory

    2010-01-01

    Los Alamos National Laboratory (LANL) uses capability reviews to assess the science, technology and engineering (STE) quality and institutional integration and to advise Laboratory Management on the current and future health of the STE. Capability reviews address the STE integration that LANL uses to meet mission requirements. The Capability Review Committees serve a dual role of providing assessment of the Laboratory's technical contributions and integration towards its missions and providing advice to Laboratory Management. The assessments and advice are documented in reports prepared by the Capability Review Committees that are delivered to the Director and to the Principal Associate Director for Science, Technology and Engineering (PADSTE). Laboratory Management will use this report for STE assessment and planning. LANL has defined fifteen STE capabilities. Electrodynamics and Accelerators is one of the seven STE capabilities that LANL Management (Director, PADSTE, technical Associate Directors) has identified for review in Fiscal Year (FY) 2010. Accelerators and electrodynamics at LANL comprise a blend of large-scale facilities and innovative small-scale research with a growing focus on national security applications. This review is organized into five topical areas: (1) Free Electron Lasers; (2) Linear Accelerator Science and Technology; (3) Advanced Electromagnetics; (4) Next Generation Accelerator Concepts; and (5) National Security Accelerator Applications. The focus is on innovative technology with an emphasis on applications relevant to Laboratory mission. The role of Laboratory Directed Research and Development (LDRD) in support of accelerators/electrodynamics will be discussed. The review provides an opportunity for interaction with early career staff. Program sponsors and customers will provide their input on the value of the accelerator and electrodynamics capability to the Laboratory mission.

  9. Design of Training Systems Utility Assessment: The Training Process Flow and System Capabilities/Requirements and Resources Models Operating in the TRAPAC Environment.

    Science.gov (United States)

    Duffy, Larry R.

    The report summarizes the results of a field test conducted for the purpose of determining the utility to Naval training of the Systems Capabilities/Requirements and Resources (SCRR) and the Training Process Flow (TPF) computer-based mathematical models. Basic descriptions of the SCRR and the TPF and their development are given. Training…

  10. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-01-01

    The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised.

  11. Assessment on Technology Management Capability Based on Technology Life Cycle%基于技术生命周期的企业技术管理能力评价研究

    Institute of Scientific and Technical Information of China (English)

    吴伟伟; 于渤; 吴冲

    2012-01-01

    基于技术生命周期理论,考察技术生命周期不同阶段技术任务的变化,根据技术管理系统运作过程识别技术管理能力的关键活动,并据此设计技术管理能力评价指标体系。选择支持向量机方法构建技术管理能力评价模型,并以A企业为例进行实证分析。结果表明:在不同技术生命周期阶段,技术管理的重点发生变化,技术管理能力的评价指标体系不同;技术管理能力评价的支持向量机模型能够对技术管理能力进行有效评价。%In the era of knowledge economy,technology management capability becomes the key for enterprises to achieve competitive advantages,and it is of great significance for firms to effectively assess their technology management capabilities.This paper,based on technology life cycle theory,explores changes of technological tasks in different stages of technology life cycle and identifies key activities of technology management capability in each stage,and design the index system for assessing technology management capability.Selecting and applying support vector machine method,the paper constructs an assessment model for technology management capability,and makes an empirical analysis of the model by taking firm A as an example.The results indicate that major tasks of technology management vary in different stages of technology life cycle and index systems of technology management capability in different stages are different;the support vector machine assessment model is effective in assessing technology management capability.

  12. The capability conundrum

    International Nuclear Information System (INIS)

    Full text: AMEC Nuclear recognises that a skilled workforce is essential to the success of its business. In the current global climate, the potential for new build in the UK, new build underway in Europe and across the world and the acceleration of Clean Up programmes, the competition for skilled staff is fierce. So how do companies develop and grow their Capability? What are the issues? There have been several initiatives undertaken in the UK to identify skills gaps. One example is an exercise undertaken by COGENT, the sector skills council for the Nuclear Sector, who undertook a comprehensive forward looking gap analysis for the industry in 2005 and who have now proposed a number of interventions to address the gaps identified, one of which is the creation of a Nuclear Skills Academy a second is the creation of Career Pathways. Some of the gaps identified cover shortages of skills that we face today but, more worryingly for the future, the projected down turn in the numbers of young people studying Science and Engineering subjects, both in schools and Universities and a shortage of apprenticeship places in the UK paints a gloomy picture. Where will our future capability come from? At AMEC Nuclear we recognise that we need to act now to protect our business and ensure we maintain, develop and grow our capability. We are working closely with COGENT to help to develop Career Pathways to encourage young people to the industry and we are delighted to have secured a place on the shadow board of the National Nuclear Skills Academy, an exciting project which will provide a focus for excellence in workforce skills development. Employers in the Nuclear industry have said that they want a Skills Academy that will provide national leadership in training provision and will move employers and employees from their current level of skills to those which will be needed to take these critical industries forward into a sustainable future in the UK. In order for us to assess what we

  13. Administrative Circular No. 26 (Rev. 9) – Recognition of Merit

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 26 (Rev. 9) entitled "Recognition of Merit”, approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 September 2011 is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp The circular was above all revised in order to integrate the new CERN Competency Model into the annual procedure of performance appraisal. It cancels and replaces Administrative Circular No. 26 (Rev. 8) entitled "Recognition of merit” of September 2008. Department Head Office HR Department

  14. A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity.

    OpenAIRE

    Adelmant, G; Bègue, A. (Alain); Stéhelin, D; Laudet, V

    1996-01-01

    Rev-erb alpha belongs to the nuclear receptor superfamily, which contains receptors for steroids, thyroid hormones, retinoic acid, and vitamin D, as well as "orphan" receptors. No ligand has been found for Rev-erb alpha to date, making it one of these orphan receptors. Similar to some other orphan receptors, Rev-erb alpha has been shown to bind DNA as a monomer on a specific sequence called a Rev-erb alpah responsive element (RevRE), but its transcriptional activity remains unclear. In this p...

  15. Capabilities for Strategic Adaptation

    DEFF Research Database (Denmark)

    Distel, Andreas Philipp

    firms’ ability to absorb and leverage new knowledge. The third paper is an empirical study which conceptualizes top managers’ resource cognition as a managerial capability underlying firms’ resource adaptation; it empirically examines the performance implications of this capability and organizational......This dissertation explores capabilities that enable firms to strategically adapt to environmental changes and preserve competitiveness over time – often referred to as dynamic capabilities. While dynamic capabilities being a popular research domain, too little is known about what these capabilities...... empirical studies through the dynamic capabilities lens and develops propositions for future research. The second paper is an empirical study on the origins of firm-level absorptive capacity; it explores how organization-level antecedents, through their impact on individual-level antecedents, influence...

  16. PNW cetacean muscle biochemistry - Muscle Myoglobin Content and Acid Buffering Capacity of Cetaceans from the Pacific Northwest to Assess Dive Capacity and the Development of Diving Capabilities

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project assesses the development of two important skeletal muscle adaptations for diving (enhanced myoglobin content and acid buffering capacities) in a range...

  17. The Convergence between Self-reports and Observer Ratings of Financial Skills and Direct Assessment of Financial Capabilities in Patients with Schizophrenia: More Detail is Not Always Better

    OpenAIRE

    Harvey, Philip D.; Stone, Laura; Lowenstein, David; Czaja, Sara J.; Heaton, Robert K.; Thomas L Patterson

    2013-01-01

    Despite multiple lines of evidence suggesting that people with schizophrenia tend to overestimate their ability to perform everyday tasks such as money management, self-report methods are still widely used to assess functioning. In today’s technology driven financial world patients are faced with increasingly complex financial management tasks. To meet these challenges adequate financial skills are required. Thus, accurate assessments of these abilities are critical to decisions regarding a p...

  18. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-03-14

    Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein) as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  19. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

    Directory of Open Access Journals (Sweden)

    Sheehy Noreen

    2011-03-01

    Full Text Available Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  20. Land Capability Classification for Crop and Fruit Product Assessment Using GIS Technology. Case Study: The Niraj River Basin (Transylvania Depression, Romania

    Directory of Open Access Journals (Sweden)

    Sanda Maria ROȘCA

    2015-04-01

    Full Text Available The efficient capitalisation of agricultural land is dependent on determining the environmental suitability of the area and on identifying the most appropriate culture types for a particular terrain. Because of its complex landforms, the anthropic pressure and the irrational use of land on large surfaces, the Basin of Niraj River was the object of a reorganising process in the production activities, by emphasising the agricultural land use as a resource for sustainable development, which has been too long underexploited.  The technique of capability classification, in collaboration with the GIS techniques of spatial analysis, represents one of the most facile and concrete ways of identifying and creating an inventory of lands which fulfil the best conditions for the creation of orchards, through the use of specific indicators: climatic, morphometric, morphologic, pedologic. The present study created a new GIS model of spatial analysis, which could offer a new approach to the classical method of land capability classification. The identification of the areas which are suitable for fruit tree cultivation was based on this model by integrating the specific indicators into databases and GIS spatial analysis equations. The results of this study highlights the maps of the land favorability for apple trees, pear trees, plum trees, cherry trees, peach trees and apricot trees and a geodatabase materialization in the maps of quality classes for orchards.

  1. Revised Safety Instruction NO. 4 (IS4 REV.)

    CERN Multimedia

    SC Secretariat

    2006-01-01

    Please note that the revised safety instruction No. 4 (IS4 REV.), entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can be obtained from the SC unit secretariat. SC Secretariat e-mail: sc.secretariat@cern.ch

  2. Revised Safety Instruction NO. 4 (IS4 REV.)

    CERN Multimedia

    2006-01-01

    Please note that the revised safety instruction no. 4 (IS4 REV.), entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can be obtained from the SC unit secretariat. SC Secretariat e-mail: sc.secretariat@cern.ch

  3. Revised Safety Instruction NO. 4 (IS4 REV.)

    CERN Multimedia

    2006-01-01

    Please note that the revised safety instruction no. 4 (IS4 REV.), entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can be obtained from the SC unit secretariat. SC Secretariat sc.secretariat@cern.ch

  4. The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker

    OpenAIRE

    Triqueneaux, Gérard; Thenot, Sandrine; Kakizawa, Tomoko; Antoch, Marina P.; Safi, Rachid; Takahashi, Joseph S.; Delaunay, Franck; Laudet, Vincent

    2004-01-01

    Rev-erbα is a ubiquitously expressed orphan nuclear receptor which functions as a constitutive transcriptional repressor and is expressed in vertebrates according to a robust circadian rhythm. We report here that two Rev-erbα mRNA isoforms, namely Rev-erbα1 and Rev-erbα2, are generated through alternative promoter usage and that both show a circadian expression pattern in an in vitro system using serum-shocked fibroblasts. Both promoter regions P1 (Rev-erbα1) and P2 (Rev-erbα2) contain severa...

  5. Dynamic Capabilities and Performance

    DEFF Research Database (Denmark)

    Wilden, Ralf; Gudergan, Siegfried P.; Nielsen, Bo Bernhard;

    2013-01-01

    Dynamic capabilities are widely considered to incorporate those processes that enable organizations to sustain superior performance over time. In this paper, we argue theoretically and demonstrate empirically that these effects are contingent on organizational structure and the competitive...... are contingent on the competitive intensity faced by firms. Our findings demonstrate the performance effects of internal alignment between organizational structure and dynamic capabilities, as well as the external fit of dynamic capabilities with competitive intensity. We outline the advantages of PLS...

  6. A unifying process capability metric

    Directory of Open Access Journals (Sweden)

    John Jay Flaig

    2009-07-01

    Full Text Available A new economic approach to process capability assessment is presented, which differs from the commonly used engineering metrics. The proposed metric consists of two economic capability measures – the expected profit and the variation in profit of the process. This dual economic metric offers a number of significant advantages over other engineering or economic metrics used in process capability analysis. First, it is easy to understand and communicate. Second, it is based on a measure of total system performance. Third, it unifies the fraction nonconforming approach and the expected loss approach. Fourth, it reflects the underlying interest of management in knowing the expected financial performance of a process and its potential variation.

  7. Diagnostic nuclear medicine. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Schiepers, C. (ed.) [UCLA David Geffen School of Medicine, Los Angeles, CA, (United States). Dept. of Molecular and Medical Pharmacology

    2006-07-01

    The field of nuclear medicine is undergoing rapid expansion, and is evolving into diagnostic molecular imaging. During recent years, dual-modality imaging with PET/CT has gained acceptance and this is currently the fastest-growing technique for oncological imaging applications. The glucose analogue FDG has held its place in diagnostic oncology, assessment of myocardial viability and diagnosis of neuro-degenerative disorders. Peptides have become even more important as imaging agents. The accuracy of hepatobiliary scintigraphy has been enhanced by cholecystokinin. The use of ACE inhibitors in the evaluation of renovascular hypertension has become the standard in renography. New instrumentation has led to faster scanners, and computer development to better image processing software. Automatic processing is more common, and standardization of protocols can be accomplished easily. The field of gene imaging has progressed, although routine clinical applications are not yet available. The present text, supplemented with many detailed and informative illustrations, represents an adjunct to the standard knowledge of diagnostic nuclear medicine and provides both the student and the professional with an overview of developments during the past decade. (orig.)

  8. Nuclear medicine. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    This second edition of the textbook on nuclear medicine is intended as a comprehensive and explanatory source of current theoretical and practical knowledge required for practical application of nuclear medicine techniques for diagnostics and therapy. The first part of the book deals with general aspects such as physical principles, the labelling and quality control of radiopharmaceuticals, and specific kinetics of some preparations, scanning techniques and the relevant equipment including aspects such as equipment handling, functional monitoring, error sources, patent positioning, as well as radiation protection and the handling of radioactive substances at the place of work. This part also explains the organisational framework of a nuclear medicine practice or department and the professional training and tasks of a radiographer in nuclear medicine. The second part is devoted to specific tasks and techniques for diagnostic assessment of the different body organs, illustrated by examples and summarised in tables given at the end of each chapter. Examples of clinical experience explain the criteria for selection of suitable diagnostic technique. (orig.) With 207 figs., 14 tabs

  9. Assessment of the Orion-SLS Interface Management Process in Achieving the EIA 731.1 Systems Engineering Capability Model Generic Practices Level 3 Criteria

    Science.gov (United States)

    Jellicorse, John J.; Rahman, Shamin A.

    2016-01-01

    NASA is currently developing the next generation crewed spacecraft and launch vehicle for exploration beyond earth orbit including returning to the Moon and making the transit to Mars. Managing the design integration of major hardware elements of a space transportation system is critical for overcoming both the technical and programmatic challenges in taking a complex system from concept to space operations. An established method of accomplishing this is formal interface management. In this paper we set forth an argument that the interface management process implemented by NASA between the Orion Multi-Purpose Crew Vehicle (MPCV) and the Space Launch System (SLS) achieves the Level 3 tier of the EIA 731.1 System Engineering Capability Model (SECM) for Generic Practices. We describe the relevant NASA systems and associated organizations, and define the EIA SECM Level 3 Generic Practices. We then provide evidence for our compliance with those practices. This evidence includes discussions of: NASA Systems Engineering Interface (SE) Management standard process and best practices; the tailoring of that process for implementation on the Orion to SLS interface; changes made over time to improve the tailored process, and; the opportunities to take the resulting lessons learned and propose improvements to our institutional processes and best practices. We compare this evidence against the practices to form the rationale for the declared SECM maturity level.

  10. ASSESSMENT OF THE BIODIVERSITY OF SAMPLES USED FOR ISOLATION OF MICROBIAL STRAINS CAPABLE OF CONVERTING STRAW DESTINED AS A SUBSTRATE FOR BIOGAS PLANT

    Directory of Open Access Journals (Sweden)

    Krystyna Cybulska

    2016-01-01

    Full Text Available In biogas plants, almost any type of organic matter can be used as a substrate to produce biogas. To make the process of methane fermentation more effective, these materials are pretreated. This applies in particular to a group of difficult substrates. Straw, due to its hemicellulose structure and saturation, is hardly fermented by biogas reactor microorganisms. The methods of post-harvest residue preparation for anaerobic digestion being applied so far are expensive, while their application has a negative effect on methanoegenic bacteria. Therefore, the microorganisms being able to degrade straw hemicellulose structure, utilisation of which could precede the proper fermentation process, have been searched for. This paper presents the results of microbial biodiversity analysis in the environmental samples being lupin, cereal, rape and maize straw as well as hay and haylage at different degradation stages. The analysis of biodiversity will help at a further stage of study to isolate active microbial strains showing cellulolytic, hemicellulolytic or ligninolytic activity which are desirable in the process of straw biodegradation. Analysis of the microbial count was performed by the method of deep inoculation on different microbiological culture media. The conducted tests include determination of the number of fungi, bacteria and actinomycetes. The results obtained confirm the usefulness of the analysed samples for isolation of microbial strains capable of converting straw preceding the biogas production.

  11. Assessment by Ames test and comet assay of toxicity potential of polymer used to develop field-capable rapid-detection device to analyze environmental samples

    Science.gov (United States)

    Hebert, Amanda; Bishop, Michelle; Bhattacharyya, Dhiman; Gleason, Karen; Torosian, Stephen

    2015-08-01

    There is need for devices that decrease detection time of food-borne pathogens from days to real-time. In this study, a rapid-detection device is being developed and assessed for potential cytotoxicity. The device is comprised of melt-spun polypropylene coupons coated via oxidative chemical vapor deposition (oCVD) with 3,4-Ethylenedioxythiophene (EDOT), for conductivity and 3-Thiopheneethanol (3TE), allowing antibody attachment. The Ames test and comet assay have been used in this study to examine the toxicity potentials of EDOT, 3TE, and polymerized EDOT-co-3TE. For this study, Salmonella typhimurium strain TA1535 was used to assess the mutagenic potential of EDOT, 3TE and the copolymer. The average mutagenic potential of EDOT, 3TE and copolymer was calculated to be 0.86, 0.56, and 0.92, respectively. For mutagenic potential, on a scale from 0 to 1, close to 1 indicates low potential for toxicity, whereas a value of 0 indicates a high potential for toxicity. The comet assay is a single-cell gel electrophoresis technique that is widely used for this purpose. This assay measures toxicity based on the area or intensity of the comet-like shape that DNA fragments produce when DNA damage has occurred. Three cell lines were assessed; FRhK-4, BHK-21, and Vero cells. After averaging the results of all three strains, the tail intensity of the copolymer was 8.8 % and tail moment was 3.0, and is most similar to the untreated control, with average tail intensity of 5.7 % and tail moment of 1.7. The assays conducted in this study provide evidence that the copolymer is non-toxic to humans.

  12. Administrative Circulars No. 12 A (Rev. 2) - "Education fees” and No. 12 B (Rev. 2) - “Education fees and language courses”

    CERN Multimedia

    2013-01-01

    Administrative Circulars No. 12 A (Rev. 2) entitled “Education fees” and No. 12 B (Rev. 2) entitled “Education fees and language courses”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, are available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 12 A (Rev. 2) is applicable to Staff Members (except former “Local Staff Members”) recruited before 1st January 2007. Administrative Circular No. 12 B (Rev. 2) is applicable to Staff Members recruited on or after 1st January 2007, to Fellows, to Scientific Associates, to Guest Professors and to former “Local Staff” recruited before 1st January 2007. They cancel and replace Administrative Circulars No. 12 A (Rev. 1/Corr.) entitled "Education fees” and No. 12 B (Rev. 1/Corr.) entitled “Edu...

  13. 尘埃粒子计数器校准和测量能力的评定%Assessment of Calibration and Measurement Capabilities of Optical Particle Counter

    Institute of Scientific and Technical Information of China (English)

    袁利根; 赵艳

    2015-01-01

    依据尘埃粒子计数器不同的校准流量点,选取不同的计量标准设备分别进行不确定度的分析与评估,并最终给出评估的结果。%According to different calibrated flow point of optical particle counter, this paper selects different measurement standard equipments for the analysis and evaluation of uncertainty, and finally gives the assessment results.

  14. Ground wave emergency network final operational capability. Environmental assessment for southern Arkansas relay node site no. RN 8C912AR

    Science.gov (United States)

    1993-02-01

    The Ground Wave Emergency Network (GWEN) is a radio communication system designed to relay emergency messages between strategic military areas in the continental United States. The system is immune to the effects of high-attitude electromagnetic pulse (HEMP) energy surges caused by nuclear bursts in the ionosphere that would disrupt conventional communications equipment such as telephones and shortwave radios. A failure of such equipment would prevent timely communications among top military and civilian leaders and strategic Air Force locations and prevent U.S. assessment and retaliation during an attack. GWEN is an essential part of a defense modernization program to upgrade and improve our nation's communications system, thereby strengthening deterrence.

  15. Administrative Circular No. 26 (Rev.10) - Recognition of merit

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 26 (Rev. 10) entitled “Recognition of Merit”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to staff members. It cancels and replaces Administrative Circular No. 26 (Rev. 9) entitled “Recognition of Merit” of December 2011. The circular was revised in order to take into account the work performed in the framework of an elective mandate during the exercise of merit recognition of staff members. In addition, the circular was revised to provide that, in the case of staff members on special leave for professional reasons for a period equal to or longer than half a year, it will no longer be possible to grant an exceptional advancement. Department Head Office HR Department

  16. Operational circular No. 1 (Rev. 1) – Operational circulars

    CERN Multimedia

    HR Department

    2011-01-01

    Operational Circular No. 1 (Rev. 1) is applicable to members of the personnel and other persons concerned. Operational Circular No. 1 (Rev. 1) entitled "Operational circulars", approved following discussion at the Standing Concertation Committee meeting on 4 May 2011, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 1 entitled "Operational Circulars” of December 1996. This new version clarifies, in particular, that operational circulars do not necessarily arise from the Staff Rules and Regulations, and the functional titles have been updated to bring them into line with the current CERN organigram. Department Head Office  

  17. Administrative Circular No. 23 (Rev. 4) - Special working hours

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

  18. Safety Instruction nº 23 (IS 23 Rev. 3)

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the revised version of Safety Instruction no 23 (IS 23 rev. 3) entitled "Criteria and standard test methods for the selection of electric cables and wires with respect to fire safety and radiation resistance" is available on the web at the following url: https://edms.cern.ch/document/335745/LAST_RELEASED/ Paper copies can also be obtained from the SC Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  19. RevPAR、GOP率、GOPPAR的联动增长

    Institute of Scientific and Technical Information of China (English)

    陈雪羽

    2007-01-01

    RevPAR,指平均每间可售客房产生的收入,其计算方式是酒店客房的全年营收总额除以全年可供出售的客房总间数,或者用更简化的方式,就是用平均房价乘以平均出租率。

  20. Valoración de la aptitud laboral en trabajadoras sanitarias con cáncer de mama Labor capability assessment for health workers with breast cancer

    Directory of Open Access Journals (Sweden)

    Consuelo Rodrigo García-Pando

    2011-09-01

    Full Text Available El cáncer de mama es el tumor más frecuente en las mujeres occidentales y afectará a una de cada ocho mujeres a lo largo de su vida. Su incidencia se ha incrementado pero la tasa de mortalidad ha descendido. El médico del trabajo debe valorar y adoptar las medidas de prevención adecuadas para atenuar los riesgos a los que puedan estar expuestos los trabajadores especialmente sensibles en el ámbito sanitario. Nuestro objetivo es proponer un método para esta valoración así como las adaptaciones necesarias para el desempeño de su tarea. Partimos de una revisión bibliográfica del cáncer de mama y se analizan los riesgos laborales del ámbito sanitario que pudieran suponer un agravamiento de las condiciones de salud de la trabajadora afectada. Exponemos un modelo de reconocimiento médico y valoración de la capacidad funcional adaptado a las secuelas más probables presentadas por las mujeres que han sido diagnosticadas de cáncer de mama, para proponer unos criterios de aptitud y recomendaciones de adecuación del puesto de trabajo.Breast cancer is the most frequent tumour in occidental women and it will affect one in eight women throughout their lives. Over the years, incidence rate has increased, whereas, mortality rate has decreased. The labour physician has to assess and decide on the suitable prevention measures to reduce those labour risks to which especially sensitive health workers may be exposed in their labour environment. Our objective is to propose a method for carrying out the assessment and the necessary adjustments for them to do their job. We begin with a bibliographic review about breast cancer to analyze the risks found in the health work environment that could worsen health conditions of the affected worker. We expose a model of medical examinations and assessment of the functional capacity, adapted to the most usual sequels shown up in women that have been diagnosed with breast cancer. We can then propose some

  1. Capabilities for innovation

    DEFF Research Database (Denmark)

    Nielsen, Peter; Nielsen, René Nesgaard; Bamberger, Simon Grandjean;

    2012-01-01

    Technological developments combined with increasing levels of competition related to the ongoing globalization imply that firms find themselves in dynamic, changing environments that call for dynamic capabilities. This challenges the internal human and organizational resources of firms in general...... and in particular their ability to develop firm-specific innovative capabilities through employee participation and creation of innovative workplaces. In this article, we argue that national institutional conditions can play an enhancing or hampering role in this. Especially the norms and values governing relations...... between employers and employees are expected to be of vital importance. This article will follow a resource-based perspective on developing dynamic capabilities in order to test the importance of enhancing human and organizational capabilities for innovation in firms. In particular, the article will focus...

  2. Ground wave emergency network final operational capability: Environmental assessment for southern Nevada relay node site number RN 8W918NV

    Science.gov (United States)

    1993-03-01

    The Ground Wave Emergency Network (GWEN) is a radio communication system designed to relay emergency messages between strategic military areas in the continental United States. The system is immune to the effects of high-altitude electromagnetic pulse (HEMP) energy surges caused by nuclear bursts in the ionosphere that would disrupt conventional communications equipment such as telephones and shortwave radios. A failure of such equipment would prevent timely communications among top military and civilian leaders and strategic Air Force locations and prevent U.S. assessment and retaliation during an attack. GWEN is an essential part of a defense modernization program to upgrade and improve our nation's communications system, thereby strengthening deterrence. The GWEN system consists of a network of relay nodes, receive-only stations, and input/output stations. Each relay node, such as the one proposed in southern Nevada consists of a guyed radio tower facility similar to those used by commercial AM broadcast transmitters.

  3. Ground wave emergency network final operational capability: Environmental assessment for northwestern Nebraska relay node, site number RN 8C930NE

    Science.gov (United States)

    1993-02-01

    The Ground Wave Emergency Network (GWEN) is a radio communication system designed to relay emergency messages between strategic military areas in the continental United States. The system is immune to the effects of high-altitude electromagnetic pulse (HEMP) energy surges caused by nuclear bursts in the ionosphere that would disrupt conventional communications equipment such as telephones and shortwave radios. A failure of such equipment would prevent timely communications among top military and civilian leaders and strategic Air Force locations and prevent U.S. assessment and retaliation during an attack. GWEN is an essential part of a defense modernization program to upgrade and improve our nation's communications system, thereby strengthening deterrence. The GWEN system consists of a network of relay nodes, receive-only stations, and input/output stations. Each relay node, such as the one proposed in northwestern Nebraska, consists of a guyed radio tower facility similar to those used by commercial AM broadcast transmitters.

  4. Education and Innovative Capabilities

    OpenAIRE

    A. Leiponen

    1996-01-01

    This study investigates the role of capabilities, acquired through education and on the job learning, in innovation. It is argued that education enhances learning and innovation because it provides employees with communication and interaction skills, and, more importantly, with abilities to receive, understand and utilize relevant knowledge, and solve problems. These dynamic capabilities are one of the sources of innovation. A dataset of 333 Finnish manufacturing firms is used to estimat...

  5. Structural Capability of an Organization toward Innovation Capability

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Momeni, Mostafa

    2016-01-01

    competitive advantage in the organizations is the innovation capability. The innovation capability is associated with other organizational capabilities, and many organizations have focused on the need to identify innovation capabilities.This research focuses on recognition of the structural aspect...

  6. Assessment of CTF Boiling Transition and Critical Heat Flux Modeling Capabilities Using the OECD/NRC BFBT and PSBT Benchmark Databases

    Directory of Open Access Journals (Sweden)

    Maria Avramova

    2013-01-01

    Full Text Available Over the last few years, the Pennsylvania State University (PSU under the sponsorship of the US Nuclear Regulatory Commission (NRC has prepared, organized, conducted, and summarized two international benchmarks based on the NUPEC data—the OECD/NRC Full-Size Fine-Mesh Bundle Test (BFBT Benchmark and the OECD/NRC PWR Sub-Channel and Bundle Test (PSBT Benchmark. The benchmarks’ activities have been conducted in cooperation with the Nuclear Energy Agency/Organization for Economic Co-operation and Development (NEA/OECD and the Japan Nuclear Energy Safety (JNES Organization. This paper presents an application of the joint Penn State University/Technical University of Madrid (UPM version of the well-known sub-channel code COBRA-TF (Coolant Boiling in Rod Array-Two Fluid, namely, CTF, to the steady state critical power and departure from nucleate boiling (DNB exercises of the OECD/NRC BFBT and PSBT benchmarks. The goal is two-fold: firstly, to assess these models and to examine their strengths and weaknesses; and secondly, to identify the areas for improvement.

  7. Capability Assessment of Wind Field Retrieval by Bistatic Radar Network%双基地多普勒雷达的风场反演能力评估

    Institute of Scientific and Technical Information of China (English)

    邱拓; 刘锦丽; 段树; 吕达仁; 毕永恒

    2015-01-01

    主、被动相结合的双基地天气雷达风场反演技术,是国际上近年来发展的新型技术。为了评估该技术的风场反演能力,将X波段双基地雷达(主、从站)联合反演的风场,与X/S波段多普勒雷达(双主动雷达)联合反演的风场进行对比。结果表明,在降水天气过程中,两者反演的风场一致性较好。此外,对方法中存在的问题也做了一些讨论。%Wind ifeld retrieval by bistatic Doppler radar is a new type of technology, which has been developed in China recently. To assess the ability of this technology, in this paper, two wind ifeld retrieval methods derived from bistatic X-band radar and X/S band Doppler radar are compared. The analysis results show that the two wind ifeld retrieval methods are reasonably consistent. In addition, some problems of the bistatic technology are also discussed.

  8. The functional assessment Berg Balance Scale is better capable of estimating fall risk in the elderly than the posturographic Balance Stability System

    Directory of Open Access Journals (Sweden)

    Vanessa Vieira Pereira

    2013-01-01

    Full Text Available The purpose of this study was to verify which instrument better identifies recurrent falls in the elderly. Ninety-eight old people, with an average age of 80±4 years, were submitted to an assessment of balance and fall risk by means of the Berg Balance Scale (BBS and the posturographic Balance Stability System (BSS. The BBS was correlated with the BSS (r=-0.27; p=0.008, age (r=-0.38; p<0.001 and number of falls (r=-0.25; p=0.013 and the analysis of logistical regression showed that the elderly classified with fall risk on the BBS presented 2.5 (95%CI 1.08-5.78 more chance of identifying who had two falls or more over the last year. The BBS identified that the greater the age the worse the functional balance and demonstrated a greater capacity to identify falls risk suffered over the last year when compared with the BSS.

  9. Building server capabilities

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    Many western companies have moved part of their operations to China in order to take advantage of cheap resources and/or to gain access to a high potential market. Depending on motive, offshore facilities usually start either as “sales-only” of products exported by headquarters or “production......-only”, exporting parts and components back to headquarter for sales in the home country. In the course of time, the role of offshore subsidiaries in a company’s operations network tends to change and, with that, the capabilities, of the subsidiaries. Focusing on Danish subsidiaries in China, the objective...... of this project is to identify and explain trajectories of offshore subsidiary capability development. The domain of inquiry is defined as value chain capabilities. Given the nature of this objective the chief methodology is longitudinal, partly retrospective, partly real-time, case studies....

  10. Visual and radar observations of birds in relation to collision risk at the Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P.; Clausager, I.; Krag Petersen, I.

    2004-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. In 2003 the studies focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging species. The Horns Rev area lies in a region known to be important for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  11. A comprehensive estimation method for enterprise capability

    Directory of Open Access Journals (Sweden)

    Tetiana Kuzhda

    2015-11-01

    Full Text Available In today’s highly competitive business world, the need for efficient enterprise capability management is greater than ever. As more enterprises begin to compete on a global scale, the effective use of enterprise capability will become imperative for them to improve their business activities. The definition of socio-economic capability of the enterprise has been given and the main components of enterprise capability have been pointed out. The comprehensive method to estimate enterprise capability that takes into account both social and economic components has been offered. The methodical approach concerning integrated estimation of the enterprise capability has been developed. Novelty deals with the inclusion of summary measure of the social component of enterprise capability to define the integrated index of enterprise capability. The practical significance of methodological approach is that the method allows assessing the enterprise capability comprehensively through combining two kinds of estimates – social and economic and converts them into a single integrated indicator. It provides a comprehensive approach to socio-economic estimation of enterprise capability, sets a formal basis for making decisions and helps allocate enterprise resources reasonably. Practical implementation of this method will affect the current condition and trends of the enterprise, help to make forecasts and plans for its development and capability efficient use.

  12. Management Innovation Capabilities

    DEFF Research Database (Denmark)

    Harder, Mie

    , the paper introduces the concept of management innovation capabilities which refers to the ability of a firm to purposefully create, extend and modify its managerial resource base to address rapidly changing environments. Drawing upon behavioral theory of the firm and the dynamic capabilities framework......Management innovation is the implementation of a new management practice, process, technique or structure that significantly alters the way the work of management is performed. This paper presents a typology categorizing management innovation along two dimensions; radicalness and complexity. Then......, the paper proposes a model of the foundations of management innovation. Propositions and implications for future research are discussed....

  13. Metrology Measurement Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Glen E. Gronniger

    2007-10-02

    This document contains descriptions of Federal Manufacturing & Technologies (FM&T) Metrology capabilities, traceability flow charts, and the measurement uncertainty of each measurement capability. Metrology provides NIST traceable precision measurements or equipment calibration for a wide variety of parameters, ranges, and state-of-the-art uncertainties. Metrology laboratories conform to the requirements of the Department of Energy Development and Production Manual Chapter 13.2, ANSI/ISO/IEC ANSI/ISO/IEC 17025:2005, and ANSI/NCSL Z540-1. FM&T Metrology laboratories are accredited by NVLAP for the parameters, ranges, and uncertainties listed in the specific scope of accreditation under NVLAP Lab code 200108-0. See the Internet at http://ts.nist.gov/Standards/scopes/2001080.pdf. These parameters are summarized. The Honeywell Federal Manufacturing & Technologies (FM&T) Metrology Department has developed measurement technology and calibration capability in four major fields of measurement: (1) Mechanical; (2) Environmental, Gas, Liquid; (3) Electrical (DC, AC, RF/Microwave); and (4) Optical and Radiation. Metrology Engineering provides the expertise to develop measurement capabilities for virtually any type of measurement in the fields listed above. A strong audit function has been developed to provide a means to evaluate the calibration programs of our suppliers and internal calibration organizations. Evaluation includes measurement audits and technical surveys.

  14. Exploration Medical Capability

    Science.gov (United States)

    Watkins, Sharmila; Baumann, David; Wu, Jimmy; Barsten, Kristina

    2010-01-01

    Exploration Medical Capability (ExMC) is an element of NASA's Human Research Program (HRP). ExMC's goal is to address the risk of the Inability to Adequately Recognize or Treat an Ill or Injured Crewmember. This poster highlights the approach ExMC has taken to address this goal and our current areas of interest. The Space Medicine Exploration Medical Condition List (SMEMCL) was created to identify medical conditions of concern during exploration missions. The list was derived from space flight medical incidents, the shuttle medical checklist, the International Space Station medical checklist, and expert opinion. The conditions on the list were prioritized according to mission type by a panel comprised of flight surgeons, physician astronauts, engineers, and scientists. From the prioritized list, the ExMC element determined the capabilities needed to address the medical conditions of concern. Where such capabilities were not currently available, a gap was identified. The element s research plan outlines these gaps and the tasks identified to achieve the desired capabilities for exploration missions. This poster is being presented to inform the audience of the gaps and tasks being investigated by ExMC and to encourage discussions of shared interests and possible future collaborations.

  15. Capabilities for Intercultural Dialogue

    Science.gov (United States)

    Crosbie, Veronica

    2014-01-01

    The capabilities approach offers a valuable analytical lens for exploring the challenge and complexity of intercultural dialogue in contemporary settings. The central tenets of the approach, developed by Amartya Sen and Martha Nussbaum, involve a set of humanistic goals including the recognition that development is a process whereby people's…

  16. ISOPHOT - Capabilities and performance

    DEFF Research Database (Denmark)

    Lemke, D.; Klaas, U.; Abolins, J.;

    1996-01-01

    ISOPHOT covers the largest wavelength range on ISO from 2.5 to 240 mu m. Its scientific capabilities include multi filter and multi-aperture photometry, polarimetry, imaging and spectrophotometry. All modes can optionally include a focal plane chopper. The backbone of the photometric calibration ...

  17. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  18. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  19. Determining your organization's 'risk capability'.

    Science.gov (United States)

    Hannah, Bill; Hancock, Melinda

    2014-05-01

    An assessment of a provider's level of risk capability should focus on three key elements: Business intelligence, including sophisticated analytical models that can offer insight into the expected cost and quality of care for a given population. Clinical enterprise maturity, marked by the ability to improve health outcomes and to manage utilization and costs to drive change. Revenue transformation, emphasizing the need for a revenue cycle platform that allows for risk acceptance and management and that provides incentives for performance against defined objectives. PMID:24851456

  20. ITER EDA design confinement capability

    Science.gov (United States)

    Uckan, N. A.

    Major device parameters for ITER-EDA and CDA are given in this paper. Ignition capability of the EDA (and CDA) operational scenarios is evaluated using both the 1 1/2-D time-dependent transport simulations and 0-D global models under different confinement ((chi((gradient)(T)(sub e)(sub crit)), empirical global energy confinement scalings, chi(empirical), etc.) assumptions. Results from some of these transport simulations and confinement assessments are summarized in and compared with the ITER CDA results.

  1. ITER EDA design confinement capability

    Energy Technology Data Exchange (ETDEWEB)

    Uckan, N.A.

    1993-06-01

    Major device parameters for ITER-EDA and CDA are given in this paper. Ignition capability of the EDA (and CDA) operational scenarios is evaluated using both the 1-1/2-D time-dependent transport simulations and 0-D global models under different confinement [{chi}({triangledown}T{sub e}){sub crit}, empirical global energy confinement scalings, {chi}(empirical), etc.] assumptions. Results from some of these transport simulations and confinement assessments are summarized in and compared with the ITER CDA reference ignition scenario.

  2. ITER EDA design confinement capability

    Energy Technology Data Exchange (ETDEWEB)

    Uckan, N.A.

    1993-01-01

    Major device parameters for ITER-EDA and CDA are given in this paper. Ignition capability of the EDA (and CDA) operational scenarios is evaluated using both the 1-1/2-D time-dependent transport simulations and 0-D global models under different confinement [[chi]([triangledown]T[sub e])[sub crit], empirical global energy confinement scalings, [chi](empirical), etc.] assumptions. Results from some of these transport simulations and confinement assessments are summarized in and compared with the ITER CDA reference ignition scenario.

  3. Targeted cleavage of HIV RRE RNA by Rev-coupled transition metal chelates.

    Science.gov (United States)

    Joyner, Jeff C; Cowan, J A

    2011-06-29

    A series of compounds that target reactive metal chelates to the HIV-1 Rev response element (RRE) mRNA have been synthesized. Dissociation constants and chemical reactivity toward HIV RRE RNA have been determined and evaluated in terms of reduction potential, coordination unsaturation, and overall charge associated with the metal-chelate-Rev complex. Ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA), and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were linked to a lysine side chain of a Rev-derived peptide by either EDC/NHS or isothiocyanate coupling. The resulting chelate-Rev (EDTA-Rev, DTPA-Rev, NTA-Rev, and DOTA-Rev) conjugates were used to form coordination complexes with Fe(2+), Co(2+), Ni(2+), and Cu(2+) such that the arginine-rich Rev peptide could mediate localization of the metal chelates to the Rev peptide's high-affinity mRNA binding partner, RRE stem loop IIB. Metal complexes of the extended peptides GGH-Rev and KGHK-Rev, which also contain N-terminal peptidic chelators (ATCUN motifs), were studied for comparison. A fluorescence titration assay revealed high-affinity RRE RNA binding by all 22 metal-chelate-Rev species, with K(D) values ranging from ~0.2 to 16 nM, indicating little to no loss of RNA affinity due to the coupling of the metal chelates to the Rev peptide. Dissociation constants for binding at a previously unobserved low-affinity site are also reported. Rates of RNA modification by each metal-chelate-Rev species were determined and varied from ~0.28 to 4.9 nM/min but were optimal for Cu(2+)-NTA-Rev. Metal-chelate reduction potentials were determined and varied from -228 to +1111 mV vs NHE under similar solution conditions, allowing direct comparison of reactivity with redox thermodynamics. Optimal activity was observed when the reduction potential for the metal center was poised between those of the two principal co-reagents for metal-promoted formation of

  4. REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells.

    Science.gov (United States)

    Wang, Wenjie; Sheng, Wenjiong; Yu, Chenxiao; Cao, Jianping; Zhou, Jundong; Wu, Jinchang; Zhang, Huojun; Zhang, Shuyu

    2015-09-01

    Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. DNA polymerase ζ (Pol ζ) is able to mediate the DNA replication bypass of DNA damage, which is suggested to be involved in chemoresistance. REV3L is the catalytic subunit of Pol ζ. Due to its critical role in translesion DNA synthesis, whether REV3L modulates cisplatin response in NSCLC cells remains unknown. In this study, REV3L overexpression and silencing H1299 cell lines were established. The reports showed that cisplatin induced the expression of REV3L by recruiting Sp1 to its promoter. Similar results were obtained when the ability of the cells to express luciferase from a platinated plasmid was measured. Co-transfection of the reporter with the REV3L overexpression vector or REV3L plus REV7L significantly enhanced the reporter activity. Nuclear condensation and fragmentation of shRNA-REV3L H1299 cells were more pronounced than shRNA-NC H1299 cells after cisplatin exposure, indicating that REV3L overexpression abolished cisplatin-induced DNA damage. Moreover, a forced expression of REV3L conferred the resistance of H1299 cells to cisplatin, whereas the knockdown of REV3L sensitized cisplatin efficacy in H1299 cells. Taken together, we demonstrated that inhibition of REV3L sensitized lung cancer H1299 cells to cisplatin treatment. Thus, REV3L may be a novel target for the chemotherapy of NSCLC. PMID:26165320

  5. Atmospheric Release Advisory Capability

    International Nuclear Information System (INIS)

    The Atmospheric Release Advisory Capability (ARAC) project is a Department of Energy (DOE) sponsored real-time emergency response service available for use by both federal and state agencies in case of a potential or actual atmospheric release of nuclear material. The project, initiated in 1972, is currently evolving from the research and development phase to full operation. Plans are underway to expand the existing capability to continuous operation by 1984 and to establish a National ARAC Center (NARAC) by 1988. This report describes the ARAC system, its utilization during the past two years, and plans for its expansion during the next five to six years. An integral part of this expansion is due to a very important and crucial effort sponsored by the Defense Nuclear Agency to extend the ARAC service to approximately 45 Department of Defense (DOD) sites throughout the continental US over the next three years

  6. Layered Composite Analysis Capability

    Science.gov (United States)

    Narayanaswami, R.; Cole, J. G.

    1985-01-01

    Laminated composite material construction is gaining popularity within industry as an attractive alternative to metallic designs where high strength at reduced weights is of prime consideration. This has necessitated the development of an effective analysis capability for the static, dynamic and buckling analyses of structural components constructed of layered composites. Theoretical and user aspects of layered composite analysis and its incorporation into CSA/NASTRAN are discussed. The availability of stress and strain based failure criteria is described which aids the user in reviewing the voluminous output normally produced in such analyses. Simple strategies to obtain minimum weight designs of composite structures are discussed. Several example problems are presented to demonstrate the accuracy and user convenient features of the capability.

  7. Building Server Capabilities

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    2013-01-01

    Many western companies have moved part of their operations to China in order to take advantage of cheap resources and/or to gain access to a high potential market. Depending on motive, offshore facilities usually start either as “sales-only” of products exported by headquarters or “production......-only”, exporting parts and components back to headquarter for sales in the home country. In the course of time, the role of offshore subsidiaries in a company’s operations network tends to change and, with that, the capabilities, of the subsidiaries. Focusing on Danish subsidiaries in China, the objective...... of this project is to identify and explain trajectories of offshore subsidiary capability development. Given the nature of this objective the chief methodology is longitudinal, partly retrospective, partly real-time, case studies....

  8. Management Innovation Capabilities

    OpenAIRE

    Harder, Mie

    2011-01-01

    Management innovation is the implementation of a new management practice, process, technique or structure that significantly alters the way the work of management is performed. This paper presents a typology categorizing management innovation along two dimensions; radicalness and complexity. Then, the paper introduces the concept of management innovation capabilities which refers to the ability of a firm to purposefully create, extend and modify its managerial resource base to add...

  9. Knowledge Management Capabilities Rubrics

    OpenAIRE

    Azizah B.A. Rahman; Sara Hassani

    2011-01-01

    Problem statement: Recently researchers discerned the vitality and importance of Knowledge Management Capabilities (KMC) evaluation in organizations. In fact evaluation of KMC helps to prevent failure in Knowledge Management (KM) projects. Approach: One of the most popular methods in the phase of evaluating KMC is Fuzzy method which evaluates seven attributes of KMC. Fuzzy needs KM experts to give their opinion about these attributes as input data. However in some organizations these experts ...

  10. Atmospheric release advisory capability

    International Nuclear Information System (INIS)

    The ARAC system (Atmospheric Release Advisory Capability) is described. The system is a collection of people, computers, computer models, topographic data and meteorological input data that together permits a calculation of, in a quasi-predictive sense, where effluent from an accident will migrate through the atmosphere, where it will be deposited on the ground, and what instantaneous and integrated dose an exposed individual would receive

  11. Responsible chain management: a capability assessment framework

    NARCIS (Netherlands)

    Bakker, de Frank; Nijhof, André

    2002-01-01

    In recent years, increased attention has been paid to issues of responsibility across the entire product lifecycle. Responsible behaviour of organizations in the product chain is dependent on the actions of other parties such as suppliers and customers. Only through co-operation and close interactio

  12. 12MW Horns Rev experiment[Wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Hasager, C.B.; Pena, A; Mikkelsen, T.; Courtney, M.; Antoniou, I.; Gryning, S.-E.; Hansen, P. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Soerensen, P.B. [DONG Energy (Denmark)

    2007-10-15

    The 12MW project with the full title '12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore' has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting and operating the instruments on the transformer platform at Horns Rev were overcome by a close collaboration between DONG energy and Risoe National Laboratory DTU. The site is presented. In particular, three tall offshore meteorological masts, up to 70 m tall, provided a useful source of meteorological data for comparison to the remotely sensed wind and turbulence observations. The comparison showed high correlation. The LIDAR and SODAR wind and turbulence observations were collected far beyond the height of the masts (up to 160 m above sea level) and the extended profiles were compared to the logarithmic wind profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported. (au)

  13. Assessment of equipment operation network capability based on the anti-missile operation loops%基于反导作战环的装备作战网络能力评估

    Institute of Scientific and Technical Information of China (English)

    芦荻; 商慧琳

    2016-01-01

    考虑到以往装备体系的研究方法忽略了装备之间的配合关系,基于网络科学思想,建立反导作战网络模型。阐明了反导作战能力生成机制,并基于此提出了反导装备体系作战网络能力评估方法,最后通过示例对所提出的建模和评估方法进行展示,证明了该方法的可行性和有效性。%Considering the interactions between equipment that have been neglected in the earlier research on equipment system-of-systems, an exploration based on networks science is conducted. The paper presents a model of anti-missile operation network and illustrates the generation progress of anti-missile operation capability, based on which a capability assessment method of anti-missile equipment system-of-systems is examined. An example of anti-missile operation network is demonstrated to illuminate the feasibility and validity of the proposed method.

  14. IAC - INTEGRATED ANALYSIS CAPABILITY

    Science.gov (United States)

    Frisch, H. P.

    1994-01-01

    The objective of the Integrated Analysis Capability (IAC) system is to provide a highly effective, interactive analysis tool for the integrated design of large structures. With the goal of supporting the unique needs of engineering analysis groups concerned with interdisciplinary problems, IAC was developed to interface programs from the fields of structures, thermodynamics, controls, and system dynamics with an executive system and database to yield a highly efficient multi-disciplinary system. Special attention is given to user requirements such as data handling and on-line assistance with operational features, and the ability to add new modules of the user's choice at a future date. IAC contains an executive system, a data base, general utilities, interfaces to various engineering programs, and a framework for building interfaces to other programs. IAC has shown itself to be effective in automatic data transfer among analysis programs. IAC 2.5, designed to be compatible as far as possible with Level 1.5, contains a major upgrade in executive and database management system capabilities, and includes interfaces to enable thermal, structures, optics, and control interaction dynamics analysis. The IAC system architecture is modular in design. 1) The executive module contains an input command processor, an extensive data management system, and driver code to execute the application modules. 2) Technical modules provide standalone computational capability as well as support for various solution paths or coupled analyses. 3) Graphics and model generation interfaces are supplied for building and viewing models. Advanced graphics capabilities are provided within particular analysis modules such as INCA and NASTRAN. 4) Interface modules provide for the required data flow between IAC and other modules. 5) User modules can be arbitrary executable programs or JCL procedures with no pre-defined relationship to IAC. 6) Special purpose modules are included, such as MIMIC (Model

  15. Security assurance capability assessment based on entropy weight method for cryptographic module%基于熵权法的密码模块安全保障能力评估

    Institute of Scientific and Technical Information of China (English)

    粟登银; 徐开勇; 高杨

    2012-01-01

    To solve the problems that the index value of cryptographic modules is not fixed, the index system is hardly built, and the security assurance ability can not be quantitatively assessed, a security assurance capability assessment for cryptographic module was proposed. The description on indexes by interval number was applied to illustrate the security attribute of cryptographic modules. This paper determined the weight vector of each period point by entropy weight coefficient method combined with expert decision weight method. According to the interval multi-attribute decision methodology, a feasible methodology was adopted to solve the interval Information Assurance ( IA) capability evaluation problem of cryptographic modules. Finally, through analyzing two kinds of cryptographic modules, the experimental results show that the proposed method is feasible.%针对密码模块这类信息安全产品指标值不固定、指标系统难以建立、安全保障能力难以定量评估的问题,提出了一种定量描述密码模块安全保障能力的可行方法.方法运用区间数描述密码模块的安全属性,采用熵权法结合主观赋权法确定每个安全属性的权重值,运用区间型多属性决策方法进行综合评价,最后运用所提方法对两种商用密码模块进行了实例分析,计算结果表明所提方法可行.

  16. Suured fondid on varunud börsile mineva Teede REV-2 aktsiaid / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2004-01-01

    Seoses Teede REV-2 aktsionäride kavaga aktsiate noteerimiseks Tallinna börsil 2005. aasta alguses, on Hansa Balti Kasvufond, Sampo Uus Euroopa Fond ja Ühispanga Kasvufond ostnud hallatavatesse investeerimisportfellidesse ehitusettevõtte aktsiaid. Diagrammid: Suure osa Teede REV-2 aktsiate omanikest tegevjuhid; Teede-Rev 2 ootab tänavu käibe kasvu. Kommenteerib Aivaras Abromavicius

  17. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee at its meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  18. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  19. 初中生“基本认知能力测验”信效度分析%Reliability and Validity Analysis of the Basic Cognitive Capability Test Assessing the Abilities of the Junior Middle School Students

    Institute of Scientific and Technical Information of China (English)

    张舒校; 王建平; 苗勤; 牛延良

    2014-01-01

    Objective To analyze the reliability and validity of the Basic Cognitive Capability Test assessing the junior middle school students.Methods 300 junior middle school students recruited through the stratified random sampling method were measured by the Basic cognitive capability test (Ⅱ) programmed by the Institute of Psychology Chinese Academic of Sciences .Results ①The test-retest reliability of the sub-scales were:Digit Copying 0.90,Character Comparison 0.73, Mental Arithmetic 0.75,Chinese Character Rotation 0.62,Digit Working Memory 0.91,Word Recognition 0.59,Meaningless Figure Recognition 0.56.②6 factors were found by the factor-analysis,including Digit Copying,Word Recognition,Digit Processing,Digit Working Memory,Character Comparison,Mental Arithmetic. Conclusion The Basic Cognitive Capability Test has showen fairly high reliability and validity when assessing the abilities of the junior middle school students .%目的:初中生“基本认知能力测验”信效度分析。方法以中国社会科学院心理研究所基本认知能力测验系统(2.0版)为工具,对分层随机抽取的300名初中生进行认知能力测试。结果①各分量表重测信度比较高,其相关系数分别是:数字拷贝0.90,汉字比较0.73,心算0.75,汉字旋转0.62,数字工作0.91,双字词再认0.59,无意义图形再认0.56,均达到显著水平(P<0.05);②因素分析发现基本认知能力测验有6个纬度,分别是:数字拷贝、双字词再认、数字加工、数字工作、汉字比较、心算。结论基本认知能力测验信效度较好,能很好的反映初中生的认知状况。

  20. Capabilities and Special Needs

    DEFF Research Database (Denmark)

    Kjeldsen, Christian Christrup

    into international consideration in relation to the implementation of the UN convention on the rights of persons with disabilities. As for the theoretical basis, the research makes use of the sociological open-ended and relational concepts of Pierre Bourdieu and the normative yardstick of the Capability Approach....... An approach that has been formulated by Amartya Sen and Martha Nussbaum, it introduces, discusses and finally analyses data with an emphasis on Martha Nussbaum’s central human functionings of practical reason and bodily health with a particular focus on the freedom to choose....

  1. Laboratory microfusion capability study

    International Nuclear Information System (INIS)

    The purpose of this study is to elucidate the issues involved in developing a Laboratory Microfusion Capability (LMC) which is the major objective of the Inertial Confinement Fusion (ICF) program within the purview of the Department of Energy's Defense Programs. The study was initiated to support a number of DOE management needs: to provide insight for the evolution of the ICF program; to afford guidance to the ICF laboratories in planning their research and development programs; to inform Congress and others of the details and implications of the LMC; to identify criteria for selection of a concept for the Laboratory Microfusion Facility and to develop a coordinated plan for the realization of an LMC. As originally proposed, the LMC study was divided into two phases. The first phase identifies the purpose and potential utility of the LMC, the regime of its performance parameters, driver independent design issues and requirements, its development goals and requirements, and associated technical, management, staffing, environmental, and other developmental and operational issues. The second phase addresses driver-dependent issues such as specific design, range of performance capabilities, and cost. The study includes four driver options; the neodymium-glass solid state laser, the krypton fluoride excimer gas laser, the light-ion accelerator, and the heavy-ion induction linear accelerator. The results of the Phase II study are described in the present report

  2. A Study Of Manufacturing Competitive Capabilities (...)

    OpenAIRE

    Luis Eduardo Solís

    2002-01-01

    (WP07/02 Clave pdf) One important reason behind total quality management implementation failure has been attributed to the poor understanding of the interdependence between quality management practices and competitive capabilities. Despite, ample literature on total quality management (TQM) techniques, no comprehensive and systematic examination of TQM relating to manufacturing competitive capabilities has been conducted. The purpose of this study is to empirically assess the relationship bet...

  3. Varying Scale and Capability of Envisat ASAR-WSM, TerraSAR-X Scansar and TerraSAR-X Stripmap Data to Assess Urban Flood Situations: A Case Study of the Mekong Delta in Can Tho Province

    Directory of Open Access Journals (Sweden)

    Stefan Dech

    2013-10-01

    Full Text Available Earth Observation is a powerful tool for the detection of floods. Microwave sensors are typically favored as they deliver data enabling water detection independent of solar illumination or cloud cover conditions. However, scale issues play an important role in radar based flood mapping. Depending on the flood related phenomenon under investigation, some sensors might be more suitable than others. In this study, we elucidate flood mapping at different spatial scale investigating the capability of Envisat ASAR Wide Swath Mode data at 150 m spatial resolution, as well as TerraSAR-X Scansar and Stripmap data at 8.25 m and 2.5 m resolution to especially assess urban flooding. For this purpose, we evaluate the results of automated multi-temporal water extraction from data sources of different scale against other parameters, such as settlement density, also taking a highly accurate building layer digitized from Quickbird data into consideration. Results reveal that while Envisat ASAR WSM derived flood maps are suitable to support the understanding of general flood patterns in a larger region, high resolution data of sensors such as TerraSAR-X is needed to truly assess urban flooding. However, even radar data of high spatial resolution still shows limitations; mainly in regions with a dense accumulation of corner reflectors leading to effects of layover, foreshortening, and shadowing, and hence the “over radiation” of flood affected areas.

  4. Qualification and application of nuclear reactor accident analysis code with the capability of internal assessment of uncertainty; Qualificacao e aplicacao de codigo de acidentes de reatores nucleares com capacidade interna de avaliacao de incerteza

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Ronaldo Celem

    2001-10-15

    This thesis presents an independent qualification of the CIAU code ('Code with the capability of - Internal Assessment of Uncertainty') which is part of the internal uncertainty evaluation process with a thermal hydraulic system code on a realistic basis. This is done by combining the uncertainty methodology UMAE ('Uncertainty Methodology based on Accuracy Extrapolation') with the RELAP5/Mod3.2 code. This allows associating uncertainty band estimates with the results obtained by the realistic calculation of the code, meeting licensing requirements of safety analysis. The independent qualification is supported by simulations with RELAP5/Mod3.2 related to accident condition tests of LOBI experimental facility and to an event which has occurred in Angra 1 nuclear power plant, by comparison with measured results and by establishing uncertainty bands on safety parameter calculated time trends. These bands have indeed enveloped the measured trends. Results from this independent qualification of CIAU have allowed to ascertain the adequate application of a systematic realistic code procedure to analyse accidents with uncertainties incorporated in the results, although there is an evident need of extending the uncertainty data base. It has been verified that use of the code with this internal assessment of uncertainty is feasible in the design and license stages of a NPP. (author)

  5. Geology of outer Horns Rev, Danish North Sea

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Joern B.; Gravesen, P.; Lomholt, S. (Geological Survey of Denmark and Greenland, Copenhagen (Denmark))

    2008-07-15

    In 2006, Dong Energy initiated the development of the Horns Rev II offshore wind farm in the North Sea. In order to evaluate and map the characteristics of the surface features of the sea bed and to characterise the subsurface in the wind farm area, the Geological Survey of Denmark and Greenland (GEUS) conducted a geophysical survey of the area. The survey utilised a variety of instruments: sparker, side-scan sonar, marine caesium magnetometer and a multibeam echo-sounder. In addition, information on the subsurface sediments was obtained by cone penetration tests (CPT) and by drilling to 30-50 m below the sea bottom. Geological correlation of the CPT results with the other survey results was extremely complicated but was required in order to understand the architecture of the ice marginal glaciotectonic complex. Information on the geology is crucial for evaluation of the geotechnical problems of the region. (au)

  6. Ensemble-based Probabilistic Forecasting at Horns Rev

    DEFF Research Database (Denmark)

    Pinson, Pierre; Madsen, Henrik

    2009-01-01

    of probabilistic forecasts, the resolution of which may be maximized by using meteorological ensemble predictions as input. The paper concentrates on the test case of the Horns Rev wind form over a period of approximately 1 year, in order to describe, apply and discuss a complete ensemble-based probabilistic...... forecasting methodology. In a first stage, ensemble forecasts of meteorological variables are converted to power through a suitable power curve model. This modelemploys local polynomial regression, and is adoptively estimated with an orthogonal fitting method. The obtained ensemble forecasts of wind power...... the benefit of yielding predictive distributions that are of increased reliability (in a probabilistic sense) in comparison with the raw ensemble forecasts, at the some time taking advantage of their high resolution. Copyright (C) 2008 John Wiley & Sons, Ltd....

  7. PHOBOS physics capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Baker, M.D. [Massachusetts Institute of Technology, Cambridge, MA (United States)

    1995-07-15

    PHOBOS is the name of a detector and of a research program to study systematically the physics of relativistic heavy-ion collisions over a large range of impact parameters and nuclear species. Collisions with a center mass energy of 200 A GeV at RHIC are expected to produce the highest energy densities ever accessible in the laboratory. In this writeup, the authors outline the physics capabilities of the PHOBOS detector and describe the detector design in terms of the general philosophy behind the PHOBOS research program. In order to make the discussion concrete, they then focus on two specific examples of physics measurements that they plan to make at RHIC: dN/d{eta} for charged particles and the mass spectrum from {phi} {yields} K{sup +}K{sup {minus}} decays.

  8. General shape optimization capability

    Science.gov (United States)

    Chargin, Mladen K.; Raasch, Ingo; Bruns, Rudolf; Deuermeyer, Dawson

    1991-01-01

    A method is described for calculating shape sensitivities, within MSC/NASTRAN, in a simple manner without resort to external programs. The method uses natural design variables to define the shape changes in a given structure. Once the shape sensitivities are obtained, the shape optimization process is carried out in a manner similar to property optimization processes. The capability of this method is illustrated by two examples: the shape optimization of a cantilever beam with holes, loaded by a point load at the free end (with the shape of the holes and the thickness of the beam selected as the design variables), and the shape optimization of a connecting rod subjected to several different loading and boundary conditions.

  9. H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.

    Directory of Open Access Journals (Sweden)

    Fu-Ming Tsai

    Full Text Available H-rev107 is a member of the HREV107 type II tumor suppressor gene family and acts as a phospholipase to catalyze the release of fatty acids from glycerophospholipid. H-rev107 has been shown to play an important role in fat metabolism in adipocytes through the PGE2/cAMP pathway, but the detailed molecular mechanism underlying H-rev107-mediated lipid degradation has not been studied. In this study, the interaction between H-rev107 and cytochrome P450 reductase (POR, which is involved in hepatic lipid content regulation, was determined by yeast two-hybrid screen and confirmed by using in vitro pull down assays and immunofluorescent staining. The expression of POR in H-rev107-expressing cells enhanced the H-rev107-mediated release of arachidonic acid. However, H-rev107 inhibited POR activity and relieved POR-mediated decreased triglyceride content in HtTA and HeLa cervical cells. The inhibitory effect of H-rev107 will be abolished when POR-expressing cells transfected with PLA2-lacking pH-rev107 or treated with PLA2 inhibitor. Silencing of H-rev107 using siRNA resulted in increased glycerol production and reversion of free fatty acid-mediated growth suppression in Huh7 hepatic cells. In summary, our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity.

  10. The capability concept – On how to define and describe capability in relation to risk, vulnerability and resilience

    International Nuclear Information System (INIS)

    Capabilities-based planning and capability assessment are high on the agendas of several countries and organisations as part of their risk management and emergency preparedness. Despite this, few definitions of capability exist, and they are not easily related to concepts such as risk, vulnerability and resilience. The aim of the present study was thus to broaden the scientific basis of the risk field to also include the concept of capability. The proposed definition is based on a recently developed risk framework, and we define capability as the uncertainty about and the severity of the consequences of an activity given the occurrence of the initiating event and the performed task. We provide examples of how the response capability for a fictive scenario can be described using this definition, and illustrate how our definition can be used to analyse capability assessments prepared according to the Swedish crisis management system. We have analysed the content of 25 capability assessments produced in 2011 by stakeholders on local, regional and national level. It was concluded that none addressed uncertainty to any appreciable extent, and only a third described capability in terms of consequences and task, making it difficult to relate these capability assessments to risk assessments. - Highlights: • Few definitions of capability relate to definitions of risk, vulnerability and resilience. • We relate capability to risk, vulnerability and resilience. • We define capability using the components uncertainty, consequences, event and task

  11. Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Heidenreich, Erich [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)]. E-mail: erich.heidenreich@meduniwien.ac.at; Eisler, Herfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Steinboeck, Ferdinand [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)

    2006-01-29

    Mutations arising in times of cell cycle arrest may provide a selective advantage for unicellular organisms adapting to environmental changes. For multicellular organisms, however, they may pose a serious threat, in that such mutations in somatic cells contribute to carcinogenesis and ageing. The budding yeast Saccharomyces cerevisiae presents a convenient model system for studying the incidence and the mechanisms of stationary-phase mutation in a eukaryotic organism. Having studied the emergence of frameshift mutants after several days of starvation-induced cell cycle arrest, we previously reported that all (potentially error-prone) translesion synthesis (TLS) enzymes identified in S. cerevisiae did not contribute to the basal level of spontaneous stationary-phase mutations. However, we observed that an increased frequency of stationary-phase frameshift mutations, brought about by a defective nucleotide excision repair (NER) pathway or by UV irradiation, was dependent on Rev3p, the catalytic subunit of the TLS polymerase zeta (Pol {zeta}). Employing the same two conditions, we now examined the effect of deletions of the genes coding for polymerase eta (Pol {eta}) (RAD30) and Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moderately influenced by a lack of Pol {eta} but completely reduced to wild type level by a knockout of the REV1 gene. UV-induced stationary-phase mutations were abundant in wild type and rad30{delta} strains, but substantially reduced in a rev1{delta} as well as a rev3{delta} strain. The similarity of the rev1{delta} and the rev3{delta} phenotype and an epistatic relationship evident from experiments with a double-deficient strain suggests a participation of Rev1p and Rev3p in the same mutagenic pathway. Based on these results, we propose that the response of cell cycle-arrested cells to an excess of exo- or endogenously induced DNA damage includes a novel replication

  12. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

    Science.gov (United States)

    Woldt, Estelle; Sebti, Yasmine; Solt, Laura A.; Duhem, Christian; Lancel, Steve; Eeckhoute, Jérôme; Hesselink, Matthijs K.C.; Paquet, Charlotte; Delhaye, Stéphane; Shin, Youseung; Kamenecka, Theodore M.; Schaart, Gert; Lefebvre, Philippe; Nevière, Rémi; Burris, Thomas P.; Schrauwen, Patrick; Staels, Bart; Duez, Hélène

    2013-01-01

    The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-α is highly expressed in oxidative skeletal muscle and plays a role in mitochondrial biogenesis and oxidative function, in gain- and loss-of function studies. Rev-erb-α-deficiency in skeletal muscle leads to reduced mitochondrial content and oxidative function, resulting in compromised exercise capacity. This phenotype was recapitulated in isolated fibers and in muscle cells upon Rev-erbα knock-down, while Rev-erb-α over-expression increased the number of mitochondria with improved respiratory capacity. Rev-erb-α-deficiency resulted in deactivation of the Stk11–Ampk–Sirt1–Ppargc1-α signaling pathway, whereas autophagy was up-regulated, resulting in both impaired mitochondrial biogenesis and increased clearance. Muscle over-expression or pharmacological activation of Rev-erb-α increased respiration and exercise capacity. This study identifies Rev-erb-α as a pharmacological target which improves muscle oxidative function by modulating gene networks controlling mitochondrial number and function. PMID:23852339

  13. 48 CFR 53.301-18 - SF 18 (Rev. 6/95), Request for Quotations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 18 (Rev. 6/95), Request for Quotations. 53.301-18 Section 53.301-18 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.301-18 SF 18 (Rev. 6/95),...

  14. 48 CFR 53.301-1414 - SF 1414 (Rev. 10/93) Consent of Surety.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 1414 (Rev. 10/93) Consent of Surety. 53.301-1414 Section 53.301-1414 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.301-1414 SF 1414 (Rev....

  15. Protective efficacy of a recombinant BAC clone of Marek's disease virus containing REV-LTR

    Science.gov (United States)

    Insertion of reticuloendotheliosis virus (REV) long-terminal repeat (LTR) into a bacterial artificial chromosome (BAC) clone of a very virulent strain of Marek’s disease (MD) virus (MDV), Md5 (Kim et al, 2011) rendered the resultant recombinant virus termed rMd5 REV-LTR BAC fully attenuated at passa...

  16. Enhanced ocean observational capability

    Energy Technology Data Exchange (ETDEWEB)

    Volpe, A M; Esser, B K

    2000-01-10

    Coastal oceans are vital to world health and sustenance. Technology that enables new observations has always been the driver of discovery in ocean sciences. In this context, we describe the first at sea deployment and operation of an inductively coupled plasma mass spectrometer (ICPMS) for continuous measurement of trace elements in seawater. The purpose of these experiments was to demonstrate that an ICPMS could be operated in a corrosive and high vibration environment with no degradation in performance. Significant advances occurred this past year due to ship time provided by Scripps Institution of Oceanography (UCSD), as well as that funded through this project. Evaluation at sea involved performance testing and characterization of several real-time seawater analysis modes. We show that mass spectrometers can rapidly, precisely and accurately determine ultratrace metal concentrations in seawater, thus allowing high-resolution mapping of large areas of surface seawater. This analytical capability represents a significant advance toward real-time observation and understanding of water mass chemistry in dynamic coastal environments. In addition, a joint LLNL-SIO workshop was convened to define and design new technologies for ocean observation. Finally, collaborative efforts were initiated with atmospheric scientists at LLNL to identify realistic coastal ocean and river simulation models to support real-time analysis and modeling of hazardous material releases in coastal waterways.

  17. Mobile systems capability plan

    International Nuclear Information System (INIS)

    This plan was prepared to initiate contracting for and deployment of these mobile system services. 102,000 cubic meters of retrievable, contact-handled TRU waste are stored at many sites around the country. Also, an estimated 38,000 cubic meters of TRU waste will be generated in the course of waste inventory workoff and continuing DOE operations. All the defense TRU waste is destined for disposal in WIPP near Carlsbad NM. To ship TRU waste there, sites must first certify that the waste meets WIPP waste acceptance criteria. The waste must be characterized, and if not acceptable, subjected to additional processing, including repackaging. Most sites plan to use existing fixed facilities or open new ones between FY1997-2006 to perform these functions; small-quantity sites lack this capability. An alternative to fixed facilities is the use of mobile systems mounted in trailers or skids, and transported to sites. Mobile systems will be used for all characterization and certification at small sites; large sites can also use them. The Carlsbad Area Office plans to pursue a strategy of privatization of mobile system services, since this offers a number of advantages. To indicate the possible magnitude of the costs of deploying mobile systems, preliminary estimates of equipment, maintenance, and operating costs over a 10-year period were prepared and options for purchase, lease, and privatization through fixed-price contracts considered

  18. Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.

    Science.gov (United States)

    Tamura, Satoru; Fujitani, Toshiaki; Kaneko, Masafumi; Murakami, Nobutoshi

    2010-06-15

    By use of the fission yeast expressing the model fusion protein comprised of GST, SV40 T antigen NLS, GFP, and Rev-NES in the bioassay, the prenylcoumarin osthol (1) was disclosed as the new Rev-export inhibitor from the MeOH extract of Cnidii Monnieris Fructus. Furthermore, 1 was also found to inhibit export the genuine Rev in HeLa cells by indirect fluorescent antibody technique. By the competitive experiment using the biotinylated probe 3, osthol (1) was revealed to inhibit nuclear export of Rev through a NES non-antagonistic mode. Structure-activity relationship analysis of several analogs of 1 clarified that both prenyl side chain and double bond adjacent to the lactone carbonyl residue play an important role in the Rev-export inhibitory potency of 1. PMID:20493693

  19. Small-scale rotor test rig capabilities for testing vibration alleviation algorithms

    Science.gov (United States)

    Jacklin, Stephen A.; Leyland, Jane Anne

    1987-01-01

    A test was conducted to assess the capabilities of a small scale rotor test rig for implementing higher harmonic control and stability augmentation algorithms. The test rig uses three high speed actuators to excite the swashplate over a range of frequencies. The actuator position signals were monitored to measure the response amplitudes at several frequencies. The ratio of response amplitude to excitation amplitude was plotted as a function of frequency. In addition to actuator performance, acceleration from six accelerometers placed on the test rig was monitored to determine whether a linear relationship exists between the harmonics of N/Rev control input and the least square error (LSE) identification technique was used to identify local and global transfer matrices for two rotor speeds at two batch sizes each. It was determined that the multicyclic control computer system interfaced very well with the rotor system and kept track of the input accelerometer signals and their phase angles. However, the current high speed actuators were found to be incapable of providing sufficient control authority at the higher excitation frequencies.

  20. Caffeine Abolishes the Ultraviolet-Induced REV3 Translesion Replication Pathway in Mouse Cells

    Directory of Open Access Journals (Sweden)

    Kouichi Yamada

    2011-11-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a photoproduct on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion. Using an alkaline sucrose density gradient sedimentation technique, we previously classified this process termed UV-induced translesion replication (UV-TLS into two types. In human cancer cells or xeroderma pigmentosum variant (XP-V cells, UV-TLS was inhibited by caffeine or proteasome inhibitors. However, in normal human cells, the process was insensitive to these reagents. Reportedly, in yeast or mammalian cells, REV3 protein (a catalytic subunit of DNA polymerase ζ is predominantly involved in the former type of TLS. Here, we studied UV-TLS in fibroblasts derived from the Rev3-knockout mouse embryo (Rev3KO-MEF. In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells, and was abolished by caffeine or MG-262. In 2 cell lines of Rev3KO-MEF (Rev3−/− p53−/−, UV-TLS was not observed. In p53KO-MEF, which is a strict control for Rev3KO-MEF, the UV-TLS response was similar to that of the wild-type. Introduction of the Rev3 expression plasmid into Rev3KO-MEF restored the UV-TLS response in selected stable transformants. In some transformants, viability to UV was the same as that in the wild-type, and the death rate was increased by caffeine. Our findings indicate that REV3 is predominantly involved in UV-TLS in mouse cells, and that the REV3 translesion pathway is suppressed by caffeine or proteasome inhibitors.

  1. Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cleasby, Mark E. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Millard, Susan; Leong, Gary M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cooney, Gregory J. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Muscat, George E.O., E-mail: g.muscat@imb.uq.edu.au [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia)

    2009-10-30

    The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

  2. Small rover exploration capabilities

    Science.gov (United States)

    Salotti, Jean-Marc; Laithier, Corentin; Machut, Benoit; Marie, Aurélien; Bruneau, Audrey; Grömer, Gernot; Foing, Bernard H.

    2015-05-01

    For a human mission to the Moon or Mars, an important question is to determine the best strategy for the choice of surface vehicles. Recent studies suggest that the first missions to Mars will be strongly constrained and that only small unpressurized vehicles will be available. We analyze the exploration capabilities and limitations of small surface vehicles from the user perspective. Following the “human centered design” paradigm, the team focused on human systems interactions and conducted the following experiments: - Another member of our team participated in the ILEWG EuroMoonMars 2013 simulation at the Mars Desert Research Station in Utah during the same period of time. Although the possible traverses were restricted, a similar study with analog space suits and quads has been carried out. - Other experiments have been conducted in an old rock quarry close to Bordeaux, France. An expert in the use of quads for all types of terrains performed a demonstration and helped us to characterize the difficulties, the risks and advantages and drawbacks of different vehicles and tools. The vehicles that will be used on the surface of Mars have not been defined yet. Nevertheless, the results of our project already show that using a light and unpressurized vehicle (in the order of 150 kg) for the mobility on the Martian surface can be a true advantage. Part of the study was dedicated to the search for appropriate tools that could be used to make the vehicles easier to handle, safer to use and more efficient in the field to cross an obstacle. The final recommendation is to use winches and ramps, which already are widely used by quad drivers. We report on the extension of the reachable areas if such tools were available. This work has been supported by ILEWG, EuroMoonMars and the Austrian Space Forum (OEWF).

  3. An investigation into women capabilities in leadership roles in Mmabatho/Mafikeng area / Boineelo Esther Molosiwa

    OpenAIRE

    Molosiwa, Boineelo Esther

    2012-01-01

    The aim of the study was to investigate women capabilities in leadership roles and the problems they are facing in managerial positions. The study was guided by two basic assumptions which are 'men and women are born equal' and that the national development will be enhanced when equal opportunities are given to both men and women. The literature rev1ew reveals that, traditionally work and family were viewed as complimentary spheres, each belonging to one sex only. Work is fo...

  4. Impact of Personnel Capabilities on Organizational Innovation Capability

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Momeni, Mostafa

    2016-01-01

    One of the most dynamic capabilities that lead to the strongest competitive advantage in the organizations is the innovation capability. Analysing the development of a firm’s innovation capability is an important research project, and can help organizations to achieve competitive advantage in thi...

  5. İlköğretim Okullarında Görev Yapan Öğretmenlerin Örgütsel Sinizm Düzeylerinin Belirlenmesi (Uşak İli Örneği Assessment of Cynicism Level of Primary School Teachers (Uşak Sample

    Directory of Open Access Journals (Sweden)

    Mehmet Akif HELVACI

    2012-09-01

    neticilerin sinizminin sebep ve sonuçlarını bilmeleri örgütteki başarı ve var ise sinizmin olumsuz sonuçlarını en etkili ve en uygun bir şekilde yönetme imkanı vermektedir. Örgütsel sinizmi etkileyen faktörlerin bilinmesi ya da algılanması yöneticilerin bu konuda duyarlı olup olumsuz sonuçlar doğurabilecek adım atmalarına engel olmaktadır. Bu araştırma, Uşak ili Milli Eğitim Bakanlığı’na bağlı kamu ilköğretim okullarında görev yapan öğretmenlerin örgütsel sinizm düzeylerini belirlemek amacıyla yapılmıştır. Aynı zamanda öğretmenlerin örgütsel sinizm düzeylerinin cinsiyet, branş, kıdem, öğrenim durumu, okulda çalışma süresi değişkenlerine göre faklılaşıp farklılaşmadığı saptanmak istenmiştir. Araştırma 2010-2011 eğitim-öğretim yılında yürütülen betimsel tarama modelinde bir çalışmadır. Araştırmanın evreni Uşak ili sınırları içerisinde bulunan tüm kamu ilköğretim okullarında görev yapan öğretmenlerden oluşmaktadır. Örneklemini ise tesadüfi örnekleme yolu ile seçilen 311 öğretmen oluşturmaktadır. Veri toplama aracı olarak Apaydın (2012 tarafından geliştirilen örgütsel sinizm ölçeği kullanılmıştır. Araştırma bulguları ilköğretim öğretmenlerin sinizm algılarının “Az düzeyinde” olduğunu göstermektedir. İlköğretim öğretmenlerinin sinizme ilişkin görüşleri cinsiyet, branş, kıdem, öğrenim durumu bakımından değişmemektedir. Okuldaki çalışma süresi bakımından, bulunduğu okulda 6-10 yıl çalışan öğretmenlerin, 1-5 yıl çalışan öğretmenlere göre daha çok sinizme sahip olduklarını göstermektedir.

  6. Sandia Laboratories technical capabilities: testing

    International Nuclear Information System (INIS)

    The testing capabilities at Sandia Laboratories are characterized. Selected applications of these capabilities are presented to illustrate the extent to which they can be applied in research and development programs

  7. Wind Farm Wake: The Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Pierre-Elouan Réthoré

    2013-02-01

    Full Text Available The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surface temperature as well as ground-based information at and near the wind farm, including Supervisory Control and Data Acquisition (SCADA data. The SCADA data reveal that the case of fog formation occurred 12 February 2008 on the 10:10 UTC. The fog formation is due to very special atmospheric conditions where a layer of cold humid air above a warmer sea surface re-condensates to fog in the wake of the turbines. The process is fed by warm humid air up-drafted from below in the counter-rotating swirl generated by the clock-wise rotating rotors. The condensation appears to take place primarily in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog.

  8. The development of capability indicators

    NARCIS (Netherlands)

    Anand, Paul; Hunter, Graham; Carter, Ian; Dowding, Keith; Guala, Francesco; Van Hees, Martin

    2009-01-01

    This paper is motivated by sustained interest in the capabilities approach to welfare economics combined with the paucity of economic statistics that measure capabilities at the individual level. Specifically, it takes a much discussed account of the normatively desirable capabilities constitutive o

  9. The Capability to Hold Property

    NARCIS (Netherlands)

    Claassen, Rutger

    2015-01-01

    This paper discusses the question of whether a capability theory of justice (such as that of Martha Nussbaum) should accept a basic “capability to hold property.” Answering this question is vital for bridging the gap between abstract capability theories of justice and their institutional implication

  10. Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary.

    Science.gov (United States)

    Abbasi, Abdolrahim; Khalaj, Maryam; Akiyama, Kouyou; Mukai, Yoshiyuki; Matsumoto, Hirokazu; Acosta, Tomas J; Said, Neveen; Yoshida, Midori; Kunieda, Tetsuo

    2015-09-01

    Rev7 is a subunit of Polζ, one of the translesion DNA synthesis (TLS) polymerases involved in DNA damage repair. We recently found that Rev7 is also essential for germ cell development in mouse. In the present study, we found the development of ovarian tumors in Rev7 mutant mouse, suggesting the involvement of TLS deficiency in the etiology of ovarian tumor. The Rev7 mutant mice showed complete lack of oocytes and follicles in the ovary. The lack of follicles causes a significant increase of gonadotropin level and an increase in the proliferation of ovarian cells. As a result, the weight of the ovaries of Rev7 mutant mice increased with age and they developed tubulostromal adenomas. However, the remarkable overgrowth of ovaries occurred after gonadotropin level decreases at older ages, suggesting gonadotropin-independent progression of the ovarian tumors. In addition, the Rev7 mutant fibroblasts and ovarian cells showed significant accumulation of DNA damage. These findings suggest that not only increased gonadotropin levels but also lack of DNA damage repair function could be responsible for the development of ovarian tumors in the Rev7 mutant mouse. PMID:26004212

  11. Capability-based computer systems

    CERN Document Server

    Levy, Henry M

    2014-01-01

    Capability-Based Computer Systems focuses on computer programs and their capabilities. The text first elaborates capability- and object-based system concepts, including capability-based systems, object-based approach, and summary. The book then describes early descriptor architectures and explains the Burroughs B5000, Rice University Computer, and Basic Language Machine. The text also focuses on early capability architectures. Dennis and Van Horn's Supervisor; CAL-TSS System; MIT PDP-1 Timesharing System; and Chicago Magic Number Machine are discussed. The book then describes Plessey System 25

  12. REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination

    OpenAIRE

    Julian E Sale

    2015-01-01

    REV7/MAD2L2 plays important roles in translesion DNA synthesis and mitotic control. Two new papers extend its gamut by revealing its unexpected participation in pathway choice during DNA double-strand break repair. By inhibiting 5′ DNA end resection downstream of 53BP1 and RIF1, REV7/MAD2L2 promotes non-homologous end joining at the expense of homologous recombination. Importantly, loss of REV7/MAD2L2 renders PARP inhibitors ineffective in BRCA1-deficient tumours, suggesting another possible ...

  13. Development of Rotor Rev Regulator Based on Integration Circuit%一种基于集成电路的旋翼转速调节器研制

    Institute of Scientific and Technical Information of China (English)

    卢建华; 刘爱元; 戴洪德

    2011-01-01

    在对直升机旋翼转速调节系统分析研究的基础上,提出了一种基于集成电路设计旋翼转速调节器的总体设计方案,完成了具体电路设计,采用Multisim仿真工具验证了模块电路设计的正确性.实际应用表明,旋翼转速调节器功能完备,各项性能指标满足直升机所提出的性能指标要求,可在直升机上推广使用.%Based the analysis and study of rotorcraft rotor revs regulation system, a collectivity design project of rotor revs regulatoe based on integration circuit was offered, and the embody circuit design was accomplished. The multisim simulation tool was adopted to validate the validity of the module circuit design.Factual application indicated that the rotor revs regulator's function was completed and every capability index fulfilled rotorcraft design demand. It could be extended to employ in helicopter.

  14. Capabilities and Incapabilities of the Capabilities Approach to Health Justice.

    Science.gov (United States)

    Selgelid, Michael J

    2016-01-01

    This first part of this article critiques Sridhar Venkatapuram's conception of health as a capability. It argues that Venkatapuram relies on the problematic concept of dignity, implies that those who are unhealthy lack lives worthy of dignity (which seems politically incorrect), sets a low bar for health, appeals to metaphysically problematic thresholds, fails to draw clear connections between appealed-to capabilities and health, and downplays the importance/relevance of health functioning. It concludes by questioning whether justice entitlements should pertain to the capability for health versus health achievements, challenging Venkatapuram's claims about the strength of health entitlements, and demonstrating that the capabilities approach is unnecessary to address social determinants of health.

  15. Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

    Directory of Open Access Journals (Sweden)

    Jun Takezawa

    2010-01-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion, extend by a few nucleotides, and dissociate from the 3′-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS or replicative bypass, may involve at least five different polymerases in mammals, although the participating polymerases and their roles have not been entirely characterized. Using siRNAs originally designed and an alkaline sucrose density gradient sedimentation technique, we verified the involvement of several polymerases in ultraviolet (UV light-induced TLS in HeLa cells. First, siRNAs to Rev3 or Rev7 largely abolished UV-TLS, suggesting that these 2 gene products, which comprise Polζ, play a main role in mutagenic TLS. Second, Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targeted siRNA also prevented TLS to a greater extent than our expectations. Forth, although siRNA to Polι had no detectable effect, that to Polκ delayed UV-TLS. To our knowledge, this is the first study reporting apparent evidence for the participation of Polκ in UV-TLS.

  16. Trends in Microfabrication Capabilities & Device Architectures.

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Todd [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Adam [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lentine, Anthony L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mudrick, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Okandan, Murat [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rodrigues, Arun F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-06-01

    The last two decades have seen an explosion in worldwide R&D, enabling fundamentally new capabilities while at the same time changing the international technology landscape. The advent of technologies for continued miniaturization and electronics feature size reduction, and for architectural innovations, will have many technical, economic, and national security implications. It is important to anticipate possible microelectronics development directions and their implications on US national interests. This report forecasts and assesses trends and directions for several potentially disruptive microfabrication capabilities and device architectures that may emerge in the next 5-10 years.

  17. Design to Process Capabilities: challenges for the use of Process Capability Databases (PCDBs) in development

    DEFF Research Database (Denmark)

    Eifler, Tobias; Göhler, Simon Moritz; Howard, Thomas J.

    2014-01-01

    capabilities may lead to low yields and a cost/time overrun, conservatively underestimated capabilities affect quality through the reduced design space, or through increased play, rattle/noise, size or weight. A possibility to overcome the subjective assessment of variation in development projects is a Process...... Capability Data Base (PCDB) offering valuable insight into the actual or expected performance of production processes (Tata and Thornton, 1999). But although the potential benefits as well as initial challenges for the use of PCDBs have been addressed in earlier research, e. g. by Delaney and Phelan (2008...

  18. Specification of advanced safety modeling requirements (Rev. 0)

    International Nuclear Information System (INIS)

    The U.S. Department of Energy's Global Nuclear Energy Partnership has lead to renewed interest in liquid-metal-cooled fast reactors for the purpose of closing the nuclear fuel cycle and making more efficient use of future repository capacity. However, the U.S. has not designed or constructed a fast reactor in nearly 30 years. Accurate, high-fidelity, whole-plant dynamics safety simulations will play a crucial role by providing confidence that component and system designs will satisfy established design limits and safety margins under a wide variety of operational, design basis, and beyond design basis transient conditions. Current modeling capabilities for fast reactor safety analyses have resulted from several hundred person-years of code development effort supported by experimental validation. The broad spectrum of mechanistic and phenomenological models that have been developed represent an enormous amount of institutional knowledge that needs to be maintained. Complicating this, the existing code architectures for safety modeling evolved from programming practices of the 1970s. This has lead to monolithic applications with interdependent data models which require significant knowledge of the complexities of the entire code in order for each component to be maintained. In order to develop an advanced fast reactor safety modeling capability, the limitations of the existing code architecture must be overcome while preserving the capabilities that already exist. To accomplish this, a set of advanced safety modeling requirements is defined, based on modern programming practices, that focuses on modular development within a flexible coupling framework. An approach for integrating the existing capabilities of the SAS4A/SASSYS-1 fast reactor safety analysis code into the SHARP framework is provided in order to preserve existing capabilities while providing a smooth transition to advanced modeling capabilities. In doing this, the advanced fast reactor safety models will

  19. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-15

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind

  20. Teede REV-2 otsustas börsile minna / Gea Velthut-Sokka

    Index Scriptorium Estoniae

    Velthut-Sokka, Gea, 1977-

    2004-01-01

    Eelmise aasta edukaima ehitusfirma Teede REV-2 ja tema suurinvestori Alta Kapital esindajad põhjendavad börsile mineku otsust. Tabelid ja diagrammid: Veerandi aktsiate omanikuvahetus börsilemineku peaprooviks

  1. Heterogeneous delivering capability promotes traffic efficiency in complex networks

    Science.gov (United States)

    Zhu, Yan-Bo; Guan, Xiang-Min; Zhang, Xue-Jun

    2015-12-01

    Traffic is one of the most fundamental dynamical processes in networked systems. With the homogeneous delivery capability of nodes, the global dynamic routing strategy proposed by Ling et al. [Phys. Rev. E81, 016113 (2010)] adequately uses the dynamic information during the process and thus it can reach a quite high network capacity. In this paper, based on the global dynamic routing strategy, we proposed a heterogeneous delivery allocation strategy of nodes on scale-free networks with consideration of nodes degree. It is found that the network capacity as well as some other indexes reflecting transportation efficiency are further improved. Our work may be useful for the design of more efficient routing strategies in communication or transportation systems.

  2. The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes

    International Nuclear Information System (INIS)

    Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but associated with a large total number of astrocytic cells in the CNS, makes human astrocytes a critical part in the analyses of potential HIV-1 reservoirs in vivo. Investigations in astrocytic cell lines and primary human fetal astrocytes revealed that limited HIV-1 replication in these cells resulted from low-level viral entry, transcription, viral protein processing, and virion maturation. Of note, a low ratio of unspliced versus spliced HIV-1-specific RNA was also investigated, as Rev appeared to act aberrantly in astrocytes, via loss of nuclear and/or nucleolar localization and diminished Rev-mediated function. Host cellular machinery enabling Rev function has become critical for elucidation of diminished Rev activity, especially for those factors leading to RNA metabolism. We have recently identified a DEAD-box protein, DDX1, as a Rev cellular co-factor and now have explored its potential importance in astrocytes. Cells were infected with HIV-1 pseudotyped with envelope glycoproteins of amphotropic murine leukemia viruses (MLV). Semi-quantitative reverse transcriptase-polymerase chain reactions (RT-PCR) for unspliced, singly-spliced, and multiply-spliced RNA clearly showed a lower ratio of unspliced/singly-spliced over multiply-spliced HIV-1-specific RNA in human astrocytes as compared to Rev-permissive, non-glial control cells. As well, the cellular localization of Rev in astrocytes was cytoplasmically dominant as compared to that of Rev-permissive, non-glial controls. This endogenous level of DDX1 expression in astrocytes was demonstrated directly to lead to a shift of Rev sub-cellular distribution dominance from nuclear and/or nucleolar to

  3. Transactional capability: Innovation's missing link

    Directory of Open Access Journals (Sweden)

    Jorge Tello-Gamarra

    2013-06-01

    Full Text Available The topic of innovation as a source of competitive advantage for firms is consolidated in the literature. An innovation-based advantage is generally achieved by following a structured process, in which technological capability plays a key role. However, a question remains in studies into innovation, which is concerned with the reasons why not all firms that develop a technological capability are innovative. Where is the missing link? Great efforts have been made in attempts to answer to this question. However, the study of this link as a source of advantage for firms deserves further attention. This article aims to present a framework with two essential dimensions: (1 the technological capability and (2 the transactional capability. Technological capability is the ability of firms to make effective use of technical knowledge in order to improve production processes and develop new products and services. Transactional capability is defined as a repertoire of abilities, processes, experiences, skills, knowledge and routines that the firm uses to minimize its transaction costs (ex¿ante and ex¿post. Given that the present study is a theoretical paper, methodologically it is based on a literature review. The main finding of this study is the identification of transactional capability as the missing link in innovation. Accordingly, to be innovative, in addition to having a technological capability, a firm needs to develop its transactional capability.

  4. Technological Dynamics and Social Capability

    DEFF Research Database (Denmark)

    Fagerberg, Jan; Feldman, Maryann; Srholec, Martin

    2014-01-01

    for the sample as a whole between 1998 and 2008. The results indicate that social capabilities, such as well-developed public knowledge infrastructure, an egalitarian distribution of income, a participatory democracy and prevalence of public safety condition the growth of technological capabilities. Possible......This article analyzes factors shaping technological capabilities in USA and European countries, and shows that the differences between the two continents in this respect are much smaller than commonly assumed. The analysis demonstrates a tendency toward convergence in technological capabilities...

  5. Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα

    Directory of Open Access Journals (Sweden)

    Shogo Sato

    2014-01-01

    Full Text Available It is now evident that many nuclear hormone receptors can modulate target gene expression. REV-ERBα, one of the nuclear hormone receptors with the capacity to alter clock function, is critically involved in lipid metabolism, adipogenesis, and the inflammatory response. Recent studies suggest that REV-ERBα plays a key role in the mediation between clockwork and inflammation. The purpose of the current study was to investigate the role of REV-ERBα in the regulation of interleukin-6 (il6 gene expression in murine macrophages. REV-ERBα agonists, or overexpression of rev-erbα in the murine macrophage cell line RAW264 cells, suppressed the induction of il6 mRNA following a lipopolysaccharide (LPS endotoxin challenge. Also, rev-erbα overexpression decreased LPS-stimulated nuclear factor κB (NFκB activation in RAW264 cells. We showed that REV-ERBα represses il6 expression not only indirectly through an NFκB binding motif but also directly through a REV-ERBα binding motif in the murine il6 promoter region. Furthermore, peritoneal macrophages from mice lacking rev-erbα increased il6 mRNA expression. These data suggest that REV-ERBα regulates the inflammatory response of macrophages through the suppression of il6 expression. REV-ERBα may therefore be identified as a potent anti-inflammatory receptor and be a therapeutic target receptor of inflammatory diseases.

  6. Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.

    Directory of Open Access Journals (Sweden)

    Min-Hsuan Lin

    Full Text Available Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, establishing that redistribution of Rev by Nullbasic is not due to direct interaction between the two proteins. Rather, Nullbasic affects subcellular localization of cellular proteins that regulate Rev trafficking. In particular, Nullbasic induced redistribution of exportin 1 (CRM1, nucleophosmin (B23 and nucleolin (C23 from the nucleolus to the nucleus when Rev was coexpressed, but never in its absence. Inhibition of the Rev:CRM1 interaction by leptomycin B or a non-interacting RevM10 mutant completely blocked redistribution of Rev by Nullbasic. Finally, Nullbasic did not inhibit importin β- or transportin 1-mediated nuclear import, suggesting that cytoplasmic accumulation of Rev was due to increased export by CRM1. Overall, our data support the conclusion that CRM1-dependent subcellular redistribution of Rev from the nucleolus by Nullbasic is not through general perturbation of either nuclear import or export. Rather, Nullbasic appears to interact with and disrupt specific components of a Rev trafficking complex required for its nucleocytoplasmic shuttling and, in particular, its nucleolar accumulation.

  7. Antioxidant status in pregnant ewes vaccinated with Rev 1 against brucellosis

    Directory of Open Access Journals (Sweden)

    W. S. Al- Khafaji

    2012-01-01

    Full Text Available The aim of this study was to examine the changes in the indicators of free radicals and antioxidant activity, represented by malondialdehyde and glutathione peroxidase in the sera of ewes vaccinated with Rev 1 vaccine. The experiment included 28 animals which were divided into four equal groups. Animals of the first and second groups were vaccinated subcutaneously with 2×109 and 2×107 colony forming units (CFU, respectively, whereas the animals of third and fourth groups were vaccinated conjunctively with 2×109 and 2×107 CFU, respectively. Sera were collected monthly for 6 months. Antibody responses were assessed by classical tests (Rose Bengal test, tube agglutination and 2-mercaptoethanol tests in comparison with competitive ELISA. The antibody titers were higher and remained for along period in the subcutaneously vaccinated groups with the two doses compared those vaccinated conjunctively. There was a significant increase in serum glutathione peroxidase activity in the 8th week post vaccination in subcutaneously vaccinated groups and during the 12th week in those vaccinated conjunctively. Significant increase of serum malondialdehyde levels occurred during the 4th week in those vaccinated conjunctively and in 8th week in those vaccinated subcutaneously. This study concluded that the route of administration of the vaccine affects glutathione peroxidase activity and malondialdehyde level, which act as indicators of oxidative stress response, more than the vaccine dose.

  8. Targeted Cleavage of HIV RRE RNA by Rev-Coupled Transition Metal Chelates

    OpenAIRE

    Joyner, Jeff C.; Cowan, J. A.

    2011-01-01

    A series of compounds that target reactive metal-chelates to the HIV-1 Rev Response Element (RRE) mRNA have been synthesized. Dissociation constants and chemical reactivity toward HIV RRE RNA have been determined and evaluated in terms of reduction potential, coordination unsaturation, and overall charge associated with the metal-chelate-rev complex. Ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA), and 1,4,7,10-tetraazacyclo-dodec...

  9. Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation.

    Science.gov (United States)

    Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J; Kamenecka, Theodore M; Solt, Laura A; Burris, Thomas P

    2016-01-01

    The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery that regulates the circadian clock. The identical core clock machinery regulates myriad endocrine and metabolic functions providing a link between sleep and metabolic health. The REV-ERBs (REV-ERBα and REV-ERBβ) are nuclear receptors that are key regulators of the molecular clock and have been successfully targeted using small molecule ligands. Recent studies in mice suggest that REV-ERB-specific synthetic agonists modulate metabolic activity as well as alter sleep architecture, inducing wakefulness during the light period. Therefore, these small molecules represent unique tools to extensively study REV-ERB regulation of sleep and wakefulness. In these studies, our aim was to further investigate the therapeutic potential of targeting the REV-ERBs for regulation of sleep by characterizing efficacy, and optimal dosing time of the REV-ERB agonist SR9009 using electroencephalographic (EEG) recordings. Applying different experimental paradigms in mice, our studies establish that SR9009 does not lose efficacy when administered more than once a day, nor does tolerance develop when administered once a day over a three-day dosing regimen. Moreover, through use of a time response paradigm, we determined that although there is an optimal time for administration of SR9009 in terms of maximal efficacy, there is a 12-hour window in which SR9009 elicited a response. Our studies indicate that the REV-ERBs are potential therapeutic targets for treating sleep problems as those encountered as a consequence of shift work or jet lag. PMID:27603791

  10. Rev-erbα in the brain is essential for circadian food entrainment

    OpenAIRE

    Julien Delezie; Stéphanie Dumont; Cristina Sandu; Sophie Reibel; Paul Pevet; Etienne Challet

    2016-01-01

    Foraging is costly in terms of time and energy. An endogenous food-entrainable system allows anticipation of predictable changes of food resources in nature. Yet the molecular mechanism that controls food anticipation in mammals remains elusive. Here we report that deletion of the clock component Rev-erbα impairs food entrainment in mice. Rev-erbα global knockout (GKO) mice subjected to restricted feeding showed reduced elevations of locomotor activity and body temperature prior to mealtime, ...

  11. Stakeholder Alignment and Changing Geospatial Information Capabilities

    Science.gov (United States)

    Winter, S.; Cutcher-Gershenfeld, J.; King, J. L.

    2015-12-01

    Changing geospatial information capabilities can have major economic and social effects on activities such as drought monitoring, weather forecasts, agricultural productivity projections, water and air quality assessments, the effects of forestry practices and so on. Whose interests are served by such changes? Two common mistakes are assuming stability in the community of stakeholders and consistency in stakeholder behavior. Stakeholder communities can reconfigure dramatically as some leave the discussion, others enter, and circumstances shift — all resulting in dynamic points of alignment and misalignment . New stakeholders can bring new interests, and existing stakeholders can change their positions. Stakeholders and their interests need to be be considered as geospatial information capabilities change, but this is easier said than done. New ways of thinking about stakeholder alignment in light of changes in capability are presented.

  12. START Analysis for ESAS Capability Needs Prioritization

    Science.gov (United States)

    Lincoln, William; Mrozinski, Joe; Hua, Hook; Merida, Sofia; Shelton, Kacie; Adumitroaie, Virgil; Weisbin, Charles R.; Derleth, Jason

    2006-01-01

    START is a tool to optimize research and development primarily for NASA missions. It was developed within the Strategic Systems Technology Program Office, a division of the Office of the Chief Technologist at NASA's Jet Propulsion Laboratory. START is capable of quantifying and comparing the risks, costs, and potential returns of technologies that are candidates for funding. START can be enormously helpful both in selecting technologies for development -- within the constraints of budget, schedule, and other resources -- and in monitoring their progress. START's methods are applicable to everything from individual tasks to multiple projects comprising entire programs of investigation. They can address virtually any technology assessment and capability prioritization issue. In this report, START is used to analyze the capability needs using data from NASA's Exploration Systems Architecture Study (ESAS).

  13. Rev-erbα in the brain is essential for circadian food entrainment.

    Science.gov (United States)

    Delezie, Julien; Dumont, Stéphanie; Sandu, Cristina; Reibel, Sophie; Pevet, Paul; Challet, Etienne

    2016-01-01

    Foraging is costly in terms of time and energy. An endogenous food-entrainable system allows anticipation of predictable changes of food resources in nature. Yet the molecular mechanism that controls food anticipation in mammals remains elusive. Here we report that deletion of the clock component Rev-erbα impairs food entrainment in mice. Rev-erbα global knockout (GKO) mice subjected to restricted feeding showed reduced elevations of locomotor activity and body temperature prior to mealtime, regardless of the lighting conditions. The failure to properly anticipate food arrival was accompanied by a lack of phase-adjustment to mealtime of the clock protein PERIOD2 in the cerebellum, and by diminished expression of phosphorylated ERK 1/2 (p-ERK) during mealtime in the mediobasal hypothalamus and cerebellum. Furthermore, brain-specific knockout (BKO) mice for Rev-erbα display a defective suprachiasmatic clock, as evidenced by blunted daily activity under a light-dark cycle, altered free-running rhythm in constant darkness and impaired clock gene expression. Notably, brain deletion of Rev-erbα totally prevented food-anticipatory behaviour and thermogenesis. In response to restricted feeding, brain deletion of Rev-erbα impaired changes in clock gene expression in the hippocampus and cerebellum, but not in the liver. Our findings indicate that Rev-erbα is required for neural network-based prediction of food availability. PMID:27380954

  14. Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

    Directory of Open Access Journals (Sweden)

    St-Laurent Georges

    2006-11-01

    Full Text Available Abstract Background The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell line. Here we examined a mechanism of interference of viral life cycle involving Rev-NF90ctv interaction. Results Since Rev:RRE complex formations depend on protein:RNA and protein:protein interactions, we investigated whether the expression of NF90ctv might interfere with Rev-mediated export of RRE-containing transcripts. When HeLa cells expressed both NF90ctv and Rev protein, we observed that NF90ctv inhibited the Rev-mediated RNA transport. In particular, three regions of NF90ctv protein are involved in blocking Rev function. Moreover, interaction of NF90ctv with the RRE RNA resulted in the expression of a reporter protein coding sequences linked to the RRE structure. Moreover, Rev influenced the subcellular localization of NF90ctv, and this process is leptomycin B sensitive. Conclusion The dsRNA binding protein, NF90ctv competes with HIV Rev function at two levels, by competitive protein:protein interaction involving Rev binding to specific domains of NF90ctv, as well as by its binding to the RRE-RNA structure. Our results are consistent with a model of Rev-mediated HIV-1 RNA export that envisions Rev-multimerization, a process interrupted by NF90ctv.

  15. Vulnerability, Health Agency and Capability to Health.

    Science.gov (United States)

    Straehle, Christine

    2016-01-01

    One of the defining features of the capability approach (CA) to health, as developed in Venkatapuram's book Health Justice, is its aim to enable individual health agency. Furthermore, the CA to health hopes to provide a strong guideline for assessing the health-enabling content of social and political conditions. In this article, I employ the recent literature on the liberal concept of vulnerability to assess the CA. I distinguish two kinds of vulnerability. Considering circumstantial vulnerability, I argue that liberal accounts of vulnerability concerned with individual autonomy, align with the CA to health. Individuals should, as far as possible, be able to make health-enabling decisions about their lives, and their capability to do so should certainly not be hindered by public policy. The CA to health and a vulnerability-based analysis then work alongside to define moral responsibilities and designate those who hold them. Both approaches demand social policy to address circumstances that hinder individuals from taking health-enabling decisions. A background condition of vulnerability, on the other hand, even though it hampers the capability for health, does not warrant the strong moral claim proposed by the CA to health to define health as a meta-capability that should guide social policy. Nothing in our designing social policy could change the challenge to health agency when we deal with background conditions of vulnerability.

  16. Identifying 21st Century Capabilities

    Science.gov (United States)

    Stevens, Robert

    2012-01-01

    What are the capabilities necessary to meet 21st century challenges? Much of the literature on 21st century skills focuses on skills necessary to meet those challenges associated with future work in a globalised world. The result is a limited characterisation of those capabilities necessary to address 21st century social, health and particularly…

  17. Application of RevPASH index in restaurant management%RevPASH指标在餐饮管理中的应用

    Institute of Scientific and Technical Information of China (English)

    王琪

    2013-01-01

    随着社会经济水平的提高,我国的餐饮业发展非常迅速。餐饮业和其他企业一样,也需要做好管理,而RevPASH指标作为一种重要的管理方法已在餐饮业得到了广泛的应用。文章主要对RevPASH指标在餐饮管理中的应用做了探讨。%With the improvement of socio-economic level, catering industry in our country is developing very quickly. The catering industry and other enterprises, also need to do a good job in the management, and take RevPASH index as an important management method, has been widely used in the food and beverage industry. This paper explored the application of RevPASH index in restaurant management.

  18. Offshore wind farms in the local environment - an examination at Horns Rev Offshore Wind Farm. Background report; Havvindmoeller i lokalomraadet - en undersoegelse ved Horns Rev Havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, Susanne

    2005-07-01

    Horns Rev Offshore Wind Farm was built in 2002. A presentation is made of a sociological, qualitative survey on the local community's reception of the offshore wind farm. The survey aims at identifying attitudes towards the farm before and after the construction, with a view to identifying possible changes in attitudes, and explain the reasons for these (ml)

  19. A Multivariate Process Capability Index

    Institute of Scientific and Technical Information of China (English)

    WANG Shaoxi; JIA Xinzhang; JIAO Huifang; BIAN Yingchao; SONG Ning; ZHAO Luyu; WEN Xin

    2006-01-01

    Process capability indices have been widely used in the manufacturing industry, providing numerical measures on process precision, process accuracy, and process performance. Capability measures for processes with a single characteristic have been investigated extensively. However, capability measures for processes with multiple characteristics are comparatively neglected. In this paper, inspired by the approach and model of process capability index investigated by K.S.Chen et al.(2003) and A.B.Yeh et al.(1998), a note model of multivariate process capability index based on non-conformity is presented. As for this index, the data of each single characteristic don't require satisfying normal distribution, of which its computing is simple and particioners will not fell too theoretical. At last the application analysis is made.

  20. Developing Collaborative Product Development Capabilities

    DEFF Research Database (Denmark)

    Mahnke, Volker; Tran, Yen

    2012-01-01

    innovation strategies’. Our analyses suggest that developing such collaboration capabilities benefits from the search for complementary practices, the combination of learning styles, and the development of weak and strong ties. Results also underscore the crucial importance of co-evolution of multi......Collaborative product development capabilities support a company’s product innovation activities. In the context of the fast fashion sector, this paper examines the development of the product development capabilities (PDC) that align product development capabilities in a dual innovation context......, one, slow paced, where the firm is well established and the other, fast paced, which represents a new competitive arena in which the company competes. To understand the process associated with collaborative capability development, we studied three Scandinavian fashion companies pursuing ‘dual...

  1. Clinical information system services and capabilities desired for scalable, standards-based, service-oriented decision support: consensus assessment of the Health Level 7 clinical decision support Work Group.

    Science.gov (United States)

    Kawamoto, Kensaku; Jacobs, Jason; Welch, Brandon M; Huser, Vojtech; Paterno, Marilyn D; Del Fiol, Guilherme; Shields, David; Strasberg, Howard R; Haug, Peter J; Liu, Zhijing; Jenders, Robert A; Rowed, David W; Chertcoff, Daryl; Fehre, Karsten; Adlassnig, Klaus-Peter; Curtis, A Clayton

    2012-01-01

    A standards-based, service-oriented architecture for clinical decision support (CDS) has the potential to significantly enhance CDS scalability and robustness. To enable such a CDS architecture, the Health Level 7 CDS Work Group reviewed the literature, hosted multi-stakeholder discussions, and consulted domain experts to identify and prioritize the services and capabilities required from clinical information systems (CISs) to enable service-oriented CDS. In addition, relevant available standards were identified. Through this process, ten CIS services and eight CIS capabilities were identified as being important for enabling scalable, service-oriented CDS. In particular, through a survey of 46 domain experts, five services and capabilities were identified as being especially critical: 1) the use of standard information models and terminologies; 2) the ability to leverage a Decision Support Service (DSS); 3) support for a clinical data query service; 4) support for an event subscription and notification service; and 5) support for a user communication service. PMID:23304315

  2. Clinical Information System Services and Capabilities Desired for Scalable, Standards-Based, Service-oriented Decision Support: Consensus Assessment of the Health Level 7 Clinical Decision Support Work Group

    Science.gov (United States)

    Kawamoto, Kensaku; Jacobs, Jason; Welch, Brandon M.; Huser, Vojtech; Paterno, Marilyn D.; Del Fiol, Guilherme; Shields, David; Strasberg, Howard R.; Haug, Peter J.; Liu, Zhijing; Jenders, Robert A.; Rowed, David W.; Chertcoff, Daryl; Fehre, Karsten; Adlassnig, Klaus-Peter; Curtis, A. Clayton

    2012-01-01

    A standards-based, service-oriented architecture for clinical decision support (CDS) has the potential to significantly enhance CDS scalability and robustness. To enable such a CDS architecture, the Health Level 7 CDS Work Group reviewed the literature, hosted multi-stakeholder discussions, and consulted domain experts to identify and prioritize the services and capabilities required from clinical information systems (CISs) to enable service-oriented CDS. In addition, relevant available standards were identified. Through this process, ten CIS services and eight CIS capabilities were identified as being important for enabling scalable, service-oriented CDS. In particular, through a survey of 46 domain experts, five services and capabilities were identified as being especially critical: 1) the use of standard information models and terminologies; 2) the ability to leverage a Decision Support Service (DSS); 3) support for a clinical data query service; 4) support for an event subscription and notification service; and 5) support for a user communication service. PMID:23304315

  3. Clinical information system services and capabilities desired for scalable, standards-based, service-oriented decision support: consensus assessment of the Health Level 7 clinical decision support Work Group.

    Science.gov (United States)

    Kawamoto, Kensaku; Jacobs, Jason; Welch, Brandon M; Huser, Vojtech; Paterno, Marilyn D; Del Fiol, Guilherme; Shields, David; Strasberg, Howard R; Haug, Peter J; Liu, Zhijing; Jenders, Robert A; Rowed, David W; Chertcoff, Daryl; Fehre, Karsten; Adlassnig, Klaus-Peter; Curtis, A Clayton

    2012-01-01

    A standards-based, service-oriented architecture for clinical decision support (CDS) has the potential to significantly enhance CDS scalability and robustness. To enable such a CDS architecture, the Health Level 7 CDS Work Group reviewed the literature, hosted multi-stakeholder discussions, and consulted domain experts to identify and prioritize the services and capabilities required from clinical information systems (CISs) to enable service-oriented CDS. In addition, relevant available standards were identified. Through this process, ten CIS services and eight CIS capabilities were identified as being important for enabling scalable, service-oriented CDS. In particular, through a survey of 46 domain experts, five services and capabilities were identified as being especially critical: 1) the use of standard information models and terminologies; 2) the ability to leverage a Decision Support Service (DSS); 3) support for a clinical data query service; 4) support for an event subscription and notification service; and 5) support for a user communication service.

  4. 能源效率提升的管理能力评价模型研究%Research on the Management Capability Assessment Model of Energy Efficiency Promotion

    Institute of Scientific and Technical Information of China (English)

    吴荻

    2013-01-01

    Firstly,this paper builds evaluation index system of energy efficiency management capabilities.Secondly,it determines the calculation methods of subjective and objective weights of each indicator by the use of G1,AHP,entropy method and standard deviation score.And with the relative entropy theory,it calculates the overall weight of various indicators,and constructs evaluation model of energy efficiency management capabilities based on the gray system theory.Then,it evaluates the energy efficiency management capabilities which take the eastern China as the research object.The result shows that the comprehensive evaluation score of energy efficiency management capabilities of the eastern China is 3.9724 which is closed to the higher level and has good development potential.The order with scores is as follows management decision-making capacities,system management capabilities,technology management capabilities,energy regulative capabilities,platform construction capacities,knowledge management capabilities,innovation management capabilities.And the evaluation values of management decision-making capacities,system management capabilities,technical management capacities are higher than the mean,the others is on the contrary.At last it puts forward the strategies to promote each capacity.%首先构建了能源效率提升的管理能力评价指标体系,其次运用G1法、熵值法、AHP法、标准离差法确定每一项指标的主观与客观权重,并根据相对熵的原理,依据所确定的各项指标主客观权重来计算各项指标的综合权重,并依据灰色系统理论构建了能源效率提升的管理能力评价模型.然后,选取中国东部地区为研究对象,对其能源效率提升的管理能力进行实证评价研究,结果发现:中国东部地区能源效率提升的管理能力综合评价分值为3.9724,处于接近较高能力的水平,发展潜力较大.各分项能力评价的分值排序依次为管理决策能力、制度管

  5. Transforming organizational capabilities in strategizing

    DEFF Research Database (Denmark)

    Jørgensen, Claus; Friis, Ole Uhrskov; Koch, Christian

    2014-01-01

    reallocated over time thereby creating a growing need for new capabilities and transformed knowledge handling routines. IT emerged into an important resource to support more complex routines of product development as well as specific management and HRM processes assisting the transformation......Offshored and networked enterprises are becoming an important if not leading organizational form and this development seriously challenges their organizational capabilities. More specifically, over the last years, SMEs have commenced entering these kinds of arrangements. As the organizational...

  6. QALYs and the capability approach.

    Science.gov (United States)

    Cookson, Richard

    2005-08-01

    This explores the applicability of Sen's capability approach to the economic evaluation of health care programmes. An individual's 'capability set' describes his freedom to choose valuable activities and states of being ('functionings'). Direct estimation and valuation of capability sets is not feasible at present. Standard preference-based methods such as willingness to pay are feasible, but problematic due to the adaptive and constructed nature of individual preferences over time and under uncertainty. An alternative is to re-interpret the QALY as a cardinal and interpersonally comparable index of the value of the individual's capability set. This approach has limitations, since the link between QALYs and capabilities is not straightforward. Nevertheless, the QALY approach is recognisable as an application of the capability approach since it pays close attention to functionings, through the use of survey-based multi-attribute health state valuation instruments, and permits conceptions of value other than the traditional utilitarian ones of choice, desire-fulfilment and happiness. Furthermore, suitably re-interpreted, it can account for (i) non-separability between health and non-health components of value; and suitably modified it can also account for (ii) process attributes of care, which may have a direct effect on non-health functionings such as comfort and dignity, and (iii) sub-group diversity in the value of the same health functionings. PMID:15693028

  7. Guidelines for System Modeling: Common Cause Failures(Rev.1)

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Mee Jeong; Yang, Joon Eon; Kang, Dae Il; Lee, Yoon Hwan

    2005-01-15

    This document, the guidelines for system modeling related to CCF analysis, is intended to provide the CCF modeling guidelines with the analyzer to construct the fault trees in the level of the capability category II of ASME PRA standard. Especially, the objective of this guideline is to provide the essential and basic guidelines and the related contents for CCF modeling to revise the Ulchin 3 and 4 PSA model for Standard Model(PRIME) within the capability category II of ASME PRA standard. This document provides the guidelines for the screening of common cause failure group, the exceptions within CCF modeling and the selection of common cause group caused by operation or design of the specific plant. In addition, this document provides the method of modeling CCF events to a Fault Tree and describes the estimation method for the probability of CCF events using {alpha}-factor model in simple. In Appendix, documentation form for walkdown which is necessary to CCF analysis, generic alpha-factor, the background for alpha-factor which are provided, and the CCF factors of the CCF basic events for UCN 3, 4 PSA model for PRIME model are given.

  8. A rev1-vpu polymorphism unique to HIV-1 subtype A and C strains impairs envelope glycoprotein expression from rev-vpu-env cassettes and reduces virion infectivity in pseudotyping assays

    International Nuclear Information System (INIS)

    Functional studies of HIV-1 envelope glycoproteins (Envs) commonly include the generation of pseudoviruses, which are produced by co-transfection of rev-vpu-env cassettes with an env-deficient provirus. Here, we describe six Env constructs from transmitted/founder HIV-1 that were defective in the pseudotyping assay, although two produced infectious virions when expressed from their cognate proviruses. All of these constructs exhibited an unusual gene arrangement in which the first exon of rev (rev1) and vpu were in the same reading frame without an intervening stop codon. Disruption of the rev1-vpu fusion gene by frameshift mutation, stop codon, or abrogation of the rev initiation codon restored pseudovirion infectivity. Introduction of the fusion gene into wildtype Env cassettes severely compromised their function. The defect was not due to altered env and rev transcription or a dominant negative effect of the expressed fusion protein, but seemed to be caused by inefficient translation at the env initiation codon. Although the rev1-vpu polymorphism affects Env expression only in vitro, it can cause problems in studies requiring Env complementation, such as analyses of co-receptor usage and neutralization properties, since 3% of subtype A, 20% of subtype C and 5% of CRF01A/E viruses encode the fusion gene. A solution is to eliminate the rev initiation codon when amplifying rev-vpu-env cassettes since this increases Env expression irrespective of the presence of the polymorphism.

  9. Expanding capabilities of the debris analysis workstation

    Science.gov (United States)

    Spencer, David B.; Sorge, Marlon E.; Mains, Deanna L.; Shubert, Ann J.; Gerhart, Charlotte M.; Yates, Ken W.; Leake, Michael

    1996-10-01

    Determining the hazards from debris-generating events is a design and safety consideration for a number of space systems, both currently operating and planned. To meet these and other requirements, the United States Air Force (USAF) Phillips Laboratory (PL) Space Debris Research Program has developed a simulation software package called the Debris Analysis Workstation (DAW). This software provides an analysis capability for assessing a wide variety of debris hazards. DAW integrates several component debris analysis models and data visualization tools into a single analysis platform that meets the needs for Department of Defense space debris analysis, and is both user friendly and modular. This allows for studies to be performed expeditiously by analysts who are not debris experts. The current version of DAW includes models for spacecraft breakup, debris orbital lifetime, collision hazard risk assessment, and collision dispersion, as well as a satellite catalog database manager, a drag inclusive propagator, a graphical user interface, and data visualization routines. Together they provide capabilities to conduct several types of analyses, ranging from range safety assessments to satellite constellation risk assessment. Work is progressing to add new capabilities with the incorporation of additional models and improved designs. The existing tools are in their initial integrated form, but the 'glue' that will ultimately bring them together into an integrated system is an object oriented language layer scheduled to be added soon. Other candidate component models under consideration for incorporation include additional orbital propagators, error estimation routines, other dispersion models, and other breakup models. At present, DAW resides on a SUNR workstation, although future versions could be tailored for other platforms, depending on the need.

  10. Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

    International Nuclear Information System (INIS)

    In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

  11. Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-15

    In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

  12. Leak detection capability in CANDU reactors

    Energy Technology Data Exchange (ETDEWEB)

    Azer, N.; Barber, D.H.; Boucher, P.J. [and others

    1997-04-01

    This paper addresses the moisture leak detection capability of Ontario Hydro CANDU reactors which has been demonstrated by performing tests on the reactor. The tests confirmed the response of the annulus gas system (AGS) to the presence of moisture injected to simulate a pressure tube leak and also confirmed the dew point response assumed in leak before break assessments. The tests were performed on Bruce A Unit 4 by injecting known and controlled rates of heavy water vapor. To avoid condensation during test conditions, the amount of moisture which could be injected was small (2-3.5 g/hr). The test response demonstrated that the AGS is capable of detecting and annunciating small leaks. Thus confidence is provided that it would alarm for a growing pressure tube leak where the leak rate is expected to increase to kg/hr rapidly. The measured dew point response was close to that predicted by analysis.

  13. Leak detection capability in CANDU reactors

    International Nuclear Information System (INIS)

    This paper addresses the moisture leak detection capability of Ontario Hydro CANDU reactors which has been demonstrated by performing tests on the reactor. The tests confirmed the response of the annulus gas system (AGS) to the presence of moisture injected to simulate a pressure tube leak and also confirmed the dew point response assumed in leak before break assessments. The tests were performed on Bruce A Unit 4 by injecting known and controlled rates of heavy water vapor. To avoid condensation during test conditions, the amount of moisture which could be injected was small (2-3.5 g/hr). The test response demonstrated that the AGS is capable of detecting and annunciating small leaks. Thus confidence is provided that it would alarm for a growing pressure tube leak where the leak rate is expected to increase to kg/hr rapidly. The measured dew point response was close to that predicted by analysis

  14. NWCF maintenance features and capabilities

    International Nuclear Information System (INIS)

    A New Waste Calcining Facility is being built at the Idaho Chemical Processing Plant to replace the existing Waste Calcining Facility which was built to demonstrate fluidized-bed solidification of highly radioactive liquid wastes. The new facility is being designed to provide a higher waste throughput, more corrosion resistant materials of construction, more effective cleanup of effluent streams, and extensive remote maintenance and equipment replacement capability. The facility will also contain extensive decontamination capability should contact maintenance become necessary. The facility is presently in construction and is scheduled for hot operation in 1980

  15. Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

    DEFF Research Database (Denmark)

    Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai;

    We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

  16. De novo mutations in Plxnd1 and Rev3l cause mobius syndrome

    OpenAIRE

    Kayserili Karabey, Hülya; Tomas-Roca, Laura; Tsaalbi-Shtylik, Anastasia; Jansen, Jacob G.; Singh, Manvendra K.; Epstein, Jonathan A.; Altunoglu, Umut; Verzijl, Harriette; Soria, Laura; van Beusekom, Ellen; Roscioli, Tony; Iqbal, Zafar; Gilissen, Christian; Hoischen, Alexander; de Brouwer,Arjan P. M.; Erasmus, Corrie; Schubert, Dirk; Brunner, Han; Aytes, Antonio Perez; Marin, Faustino; Aroca, Pilar; Carta, Arturo; de Wind, Niels; Padberg, George W.; van Bokhoven, Hans

    2015-01-01

    Mobius syndrome (MBS) is a neurological disorder that is characterized by paralysis of the facial nerves and variable other congenital anomalies. The aetiology of this syndrome has been enigmatic since the initial descriptions by von Graefe in 1880 and by Mobius in 1888, and it has been debated for decades whether MBS has a genetic or a non-genetic aetiology. Here, we report de novo mutations affecting two genes, PLXND1 and REV3L in MBS patients. PLXND1 and REV3L represent totally unrelated p...

  17. Administrative Circular No. 13 (Rev. 4) - Guarantees for representatives of the personnel

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 13 (Rev. 4) entitled "Guarantees for representatives of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208527.   This revised circular cancels and replaces Administrative Circular No. 13 (Rev. 3) also entitled "Guarantees for representatives of the personnel" of January 2014. This document contains a single change to reflect the terminology under the new career structure: the term "career path" is replaced by "grade". This circular will enter into force on 1st September 2016.

  18. Administrative Circular No. 22B (Rev. 2) - Compensation for hours of long-term shift work

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 22B (Rev. 2) entitled "Compensation for hours of long-term shift work",  approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208538.   This revised circular cancels and replaces Administrative Circular No. 22B (Rev. 1) also entitled "Compensation for hours of long-term shift work" of March 2011. This document contains minor changes to reflect the new career structure. This circular will enter into force on 1st September 2016.

  19. Administrative Circular No. 11 (Rev. 4) - Categories of members of the personnel

    CERN Multimedia

    HR Department

    2016-01-01

    Administrative Circular No. 11 (Rev. 4) entitled "Categories of members of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 29 April 2016, will be available on 1 August 2016 via this following link.    This revised circular cancels and replaces the Administrative Circular No. 11 (Rev. 3) also entitled "Categories of members of the personnel" of September 2014. The main changes concern the status of apprentices and their transfer from the category of employed members of personnel to associated members of personnel. This circular will enter into force on 1 August 2016. Department Head Office

  20. Switching studies for the Horns Rev 2 wind farm main cable

    OpenAIRE

    Jensen, Christian Flytkjær; Faria da Silva, Filipe; Bak, Claus Leth; Wiechowski, W.

    2011-01-01

    This article proposes a method of constructing a PSCAD model suitable for switching studies in a system containing long HVAC cables. The transmission network connection to the 215 MW offshore wind farm Horns Rev 2 is used as a case study. The connection to Horns Rev 2 consists of two land cable sections with a total length of 57.7 km and a 42 km long submarine cable. The submarine cable is a three phase type of cable, and three single conductor cables are used for the land cable. Methods of r...

  1. RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

    DEFF Research Database (Denmark)

    Wernersson, Rasmus; Pedersen, Anders Gorm

    2003-01-01

    proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...... alignment by 'reverse translation' of the aligned protein sequences. In the resulting DNA alignment, gaps occur in groups of three corresponding to entire codons, and analogous codon positions are therefore always lined up. These features are useful when constructing multiple DNA alignments for phylogenetic...

  2. Quantifying Adversary Capabilities to Inform Defensive Resource Allocation.

    Science.gov (United States)

    Wang, Chen; Bier, Vicki M

    2016-04-01

    We propose a Bayesian Stackelberg game capable of analyzing the joint effects of both attacker intent and capabilities on optimal defensive strategies. The novel feature of our model is the use of contest success functions from economics to capture the extent to which the success of an attack is attributable to the adversary's capability (as well as the level of defensive investment), rather than pure luck. Results of a two-target example suggest that precise assessment of attacker intent may not be necessary if we have poor estimates of attacker capability. PMID:25929274

  3. Hydroacoustic registration of fish abundance of offshore wind farms. Horns Rev offshore wind farm. Annual report 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Hvidt, C.B.; Bruenner, L.; Reier Knudsen, F.

    2005-05-15

    Elsam Engineering AS has approved the implementation of a project concerning the registration of fish communities in Horns Rev Offshore Wind Farm with use of hydroacoustic methods. In a joint effort, Bio/consult as, Carl Bro as and SIMRAD AS have monitored the fish communities at Horns Rev Offshore Wind Farm using a new hydroacoustic methodology. The new hydroacoustic technique combines the use of scientific sonar acoustics with GPS to determine the density, diversity and location of fish. The objectives of this project were to test the possibility of using hydroacoustic techniques as alternative methods to traditional techniques to assess the fish assemblage inhabiting offshore wind farms and to investigate the possible effect from the wind farm and hard bottom substrates (turbine foundations) on fish abundance. The field study was carried out October 9-10, 2004 and consisted of four horizontal hydroacoustic survey transects each covering impact and reference areas. Transects were surveyed in order to achieve identical impact and reference transect pairs concerning environment, topography and time correspondence. The hydroacoustic equipment consisted of a SIMRAD EK60/EY60 echo sounder with a split-beam transducer (Simrad ES 120-4x10) mounted on a pan and tilt unit, a transceiver, a laptop extended with a GPS-receiver and additional large external hard discs. The raw data files from EK60 were converted to echogram files suitable for the post processing application, Sonar5-Pro. The Sonar5-Pro software makes it possible to filter out echo detections from the surface and the bottom, as well as perform cross filter detection. The validity of the results using the hydroacoustic method is high due to the cross filtering and single target tracking technique. From the hydroacoustic results, no or very little effect from the wind farm or from hard bottom substrates was found on the fish densities at Horns Rev Wind Farm at the time of the survey. The execution of the field

  4. Advanced Simulation and Computing FY10-FY11 Implementation Plan Volume 2, Rev. 0.5

    Energy Technology Data Exchange (ETDEWEB)

    Meisner, R; Peery, J; McCoy, M; Hopson, J

    2009-09-08

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the surety and reliability of the U.S. nuclear stockpile. The SSP uses past nuclear test data along with current and future non-nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering (D&E) programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of current facilities and programs along with new experimental facilities and computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources to support the annual stockpile assessment and certification, to study advanced nuclear weapons design and manufacturing processes, to analyze accident scenarios and weapons aging, and to provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balanced resource, including technical staff, hardware, simulation software, and computer science solutions. In its first decade, the ASC strategy focused on demonstrating simulation capabilities of unprecedented scale in three spatial dimensions. In its second decade, ASC is focused on increasing its predictive capabilities in a three-dimensional (3D) simulation environment while maintaining support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (focused on sufficient resolution, dimensionality and scientific details); to quantify critical margins and uncertainties (QMU); and to resolve increasingly difficult analyses needed for the SSP. Moreover, ASC has restructured its business model

  5. Advanced Simulation and Computing FY10-11 Implementation Plan Volume 2, Rev. 0

    Energy Technology Data Exchange (ETDEWEB)

    Carnes, B

    2009-06-08

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the surety and reliability of the U.S. nuclear stockpile. The SSP uses past nuclear test data along with current and future non-nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of current facilities and programs along with new experimental facilities and computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources to support the annual stockpile assessment and certification, to study advanced nuclear weapons design and manufacturing processes, to analyze accident scenarios and weapons aging, and to provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balanced resource, including technical staff, hardware, simulation software, and computer science solutions. In its first decade, the ASC strategy focused on demonstrating simulation capabilities of unprecedented scale in three spatial dimensions. In its second decade, ASC is focused on increasing its predictive capabilities in a three-dimensional simulation environment while maintaining support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (focused on sufficient resolution, dimensionality and scientific details); to quantify critical margins and uncertainties (QMU); and to resolve increasingly difficult analyses needed for the SSP. Moreover, ASC has restructured its business model from one that

  6. FY07-08 Implementation Plan Volume 2, Rev. 0.5

    Energy Technology Data Exchange (ETDEWEB)

    Baron, A L

    2006-09-06

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the safety and reliability of the U.S. nuclear stockpile. The SSP uses past nuclear test data along with current and future nonnuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program will require the continued use of current facilities and programs along with new experimental facilities and computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources to support the annual stockpile assessment and certification, to study advanced nuclear-weapons design and manufacturing processes, to analyze accident scenarios and weapons aging, and to provide the tools to enable Stockpile Life Extension Programs (SLEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balanced resource, including technical staff, hardware, simulation software, and computer science solutions. In its first decade, the ASC strategy focused on demonstrating simulation capabilities of unprecedented scale in three spatial dimensions. In its second decade, ASC is focused on increasing its predictive capabilities in a three-dimensional simulation environment while maintaining the support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (focused on sufficient resolution, dimensionality and scientific details); to quantify critical margins and uncertainties (QMU); and to resolve increasingly difficult analyses needed for the SSP. Moreover, ASC has restructured its business model from

  7. Advanced Simulation and Computing FY09-FY10 Implementation Plan Volume 2, Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    Kissel, L

    2009-04-01

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the surety and reliability of the U.S. nuclear stockpile. The SSP uses past nuclear test data along with current and future non-nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of current facilities and programs along with new experimental facilities and computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources to support the annual stockpile assessment and certification, to study advanced nuclear weapons design and manufacturing processes, to analyze accident scenarios and weapons aging, and to provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balanced resource, including technical staff, hardware, simulation software, and computer science solutions. In its first decade, the ASC strategy focused on demonstrating simulation capabilities of unprecedented scale in three spatial dimensions. In its second decade, ASC is focused on increasing its predictive capabilities in a three-dimensional simulation environment while maintaining support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (focused on sufficient resolution, dimensionality and scientific details); to quantify critical margins and uncertainties (QMU); and to resolve increasingly difficult analyses needed for the SSP. Moreover, ASC has restructured its business model from one that

  8. Verification of failure avoidance concepts in R6 Rev3

    International Nuclear Information System (INIS)

    The first part of this Report outlines how recent developments in fracture mechanics have led to a more accurate interpretation of the two-criteria approach to defect assessment. The implementation of these developments into Revision 3 of the Central Electricity Generating Board code of practice for the assessment of the defect tolerance of structures (R6) is described. One of the key elements of the revised version is the recommendation that the failure assessment line should be derived from the actual tensile stress/strain properties of the material. The second part of the Report addresses the validation of the method, which is a crucial step on the way to obtaining acceptance of R6 by, in particular, the regulatory bodies. The range of structures used to validate the procedure is illustrated by two examples. The use of conservative data and assumptions is fundamental to the R6 philosophy, which means that the procedure should not be used as a predictive tool. In the second example the importance of making these conservative assumptions is clearly illustrated. (author)

  9. Data upload capability of 3G mobile phones.

    Science.gov (United States)

    Moon, Jon K; Barden, Charles M; Wohlers, Erica M

    2009-01-01

    Mobile phones are becoming an important platform to measure free-living energy balance and to support weight management therapies. Sensor data, camera images and user input are needed by clinicians and researchers in close to real time. We assessed upload (reverse link) data transport rates for 2007-2008 model mobile phones on two major US wireless systems. Even the slowest phone (EVDO Rev 0) reliably uploaded 40 MB of data in less than 1 h. More than 95% of file uploads were successful in tests that simulated normal phone use over 3 d. Practical bandwidth and data currency from typical smart phones will likely keep pace with the data needs of energy balance studies and weight management therapy. PMID:19963469

  10. 民用飞机客户服务体系能力成熟度评估方法%Capability Maturity Assessment Method for Civil Aircraft Customer Service System

    Institute of Scientific and Technical Information of China (English)

    徐峻; 陈林; 孙蕾

    2014-01-01

    According to the basic ideas of the Capability Maturity Model (CMM), the Maturity Model for civil aircraft customer service system was established on ifve big aspects: the engineering and technical support, marketing and customer support, spare parts support, flight training, technical publications, and so on. Then, Capability Maturity comprehensive evaluation method was given. With the survey results airlines of customer service satisfaction, and weights which were determined by expert advice, using the multi-level fuzzy comprehensive evaluation method , maturity level on the actual customer service system for comac's customer service center are evaluated, making the current maturity level of clear and continuous improvement Suggestions are put forward.%针对民用飞机客户服务中心的客户服务体系,根据成熟度模型(Capability Maturity Model,CMM)的基本思想,从工程技术支持、市场与客户支援、航材支援、飞行培训和技术出版物等5大方面入手,建立民用飞机客户服务体系的成熟度模型,提出其能力成熟度综合评价方法。通过参考中国商飞开展的客户服务满意度调查问卷结果,并融合专家意见确定的权重值,利用多层次模糊综合评价方法,对中国商飞客户服务中心现有的客户服务体系进行成熟度等级评价,明确其目前所处的成熟度层级,并提出持续改进的建议。

  11. Hanford Soil Inventory Model (SIM) Rev. 1 Users Guide

    International Nuclear Information System (INIS)

    The focus of the development and application of a soil inventory model as part of the Remediation and Closure Science (RCS) Project managed by PNNL was to develop a probabilistic approach to estimate comprehensive, mass balanced-based contaminant inventories for the Hanford Site post-closure setting. The outcome of this effort was the Hanford Soil Inventory Model (SIM). This document is a user's guide for the Hanford SIM. The principal project requirement for the SIM was to provide comprehensive quantitative estimates of contaminant inventory and its uncertainty for the various liquid waste sites, unplanned releases, and past tank farm leaks as a function of time and location at Hanford. The majority, but not all of these waste sites are in the 200 Areas of Hanford where chemical processing of spent fuel occurred. A computer model capable of performing these calculations and providing satisfactory quantitative output representing a robust description of contaminant inventory and uncertainty for use in other subsequent models was determined to be satisfactory to address the needs of the RCS Project. The ability to use familiar, commercially available software on high-performance personal computers for data input, modeling, and analysis, rather than custom software on a workstation or mainframe computer for modeling, was desired

  12. Judgmental Forecasting of Operational Capabilities

    DEFF Research Database (Denmark)

    Hallin, Carina Antonia; Tveterås, Sigbjørn; Andersen, Torben Juul

    This paper explores a new judgmental forecasting indicator, the Employee Sensed Operational Capabilities (ESOC). The purpose of the ESOC is to establish a practical prediction tool that can provide early signals about changes in financial performance by gauging frontline employees’ sensing...

  13. Building server capabilities in China

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi; Slepniov, Dmitrij; Wæhrens, Brian Vejrum;

    2012-01-01

    The purpose of this paper is to further our understanding of multinational companies building server capabilities in China. The paper is based on the cases of two western companies with operations in China. The findings highlight a number of common patterns in the 1) managerial challenges related...

  14. Microfoundations of Routines and Capabilities

    DEFF Research Database (Denmark)

    Felin, Teppo; Foss, Nicolai Juul; Heimriks, Koen H.;

    We discuss the microfoundations of routines and capabilities, including why a microfoundations view is needed and how it may inform work on organizational and competitive heterogeneity. Building on extant research, we identify three primary categories of micro-level components underlying routines...

  15. Microfoundations of Routines and Capabilities

    DEFF Research Database (Denmark)

    Felin, Tippo; Foss, Nicolai Juul; Heimericks, Koen H.;

    2012-01-01

    This article introduces the Special Issue and discusses the microfoundations of routines and capabilities, including why a microfoundations view is needed and how it may inform work on organizational and competitive heterogeneity. Building on extant research, we identify three primary categories ...

  16. ABOUT SOLIDWORKS SUSTAINABILITY MODULE CAPABILITIES

    Directory of Open Access Journals (Sweden)

    Cătălin IANCU

    2014-05-01

    Full Text Available In the paper are presented the SolidWorks analysis steps to be taken in order to study sustainability of parts or assemblies designed. There are presented the software capabilities and the settings that have to be done for such analysis and the results shown by software.

  17. Demonstration MTI/SAR capability

    NARCIS (Netherlands)

    Vries, F.P.P. de; Broek, A.C. van den; Otten, M.P.G.; Groot, J.S.; Steeghs, T.P.H.; Dekker, R.J.; Rossum, W.L. van

    2001-01-01

    The aim of this project is to demonstrate to the Dutch armed forces the capability of MTI (Moving Target Indicator) and SAR (Synthetic Aperture Radar). This is done with the Dutch PHARUS sensor. The sensor is used to demonstrate how a phased array antenna can be used as an MTI/SAR sensor combination

  18. Radiology of chest diseases. 3. tot. rev. and upd. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Lange, S. [Knappschaftshospital Recklinghausen (Germany). Dept. of Radiology; Walsh, G. [Royal Berkshire Hospital, Reading (United Kingdom). Dept. of Radiology

    2007-07-01

    Almost a decade has passed since the publication of the second edition of Radiology of Chest Diseases in 1997. This period has seen tremendous advances in imaging technology. Single-slice helical CT has given way to multi-detector row CT (MDCT), and with increasing numbers of detectors we move toward the concept of 'isotropic' spatial resolution. This has been combined with decreased scan times and improved temporal resolution. The rapid evolution of CT technology has led to marked improvements in the quality of thoracic CT studies and has allowed us to contemplate and perform with some success cardiac evaluation and CT coronary angiography. Positron emission tomography (PET)/PET-CT has been incorporated into everyday clinical practice in the past decade and today plays a significant role in imagin evaluation of thoracic disease, particularly in oncologic staging and assessment. Advances in magnetic resonance imaging (MRI) today allow improved cardiac evaluation and particularly myocardial first-pass perfusion and viability assessment. In this text, we have tried to convey how these exciting advances in technology fit into the clinical setting of cardiothoracic imaging evaluation. We also recognize the ever-increasing availability and use of CT as an 'early' second-line imaging tool in assessment of the patient with suspected pulmonary disease and have placed a greater emphasis on the role of high-resolution/thin-section CT in evaluation of parenchymal lung disease. A new chapter on interventional procedures in the thorax describes a spectrum of procedures from the standard image-guided biopsy and drainage through to the more specialized interventions of pulmonary AVM and pulmonary false aneurysm embolization. Once again, we hope that this text conveys the fascinating diversity of cardiothoracic radiology and that it will prove a useful guide to the practitioner in the every-day clinical setting. (orig.)

  19. License Application Design Selection Report, REV 01. August 1999

    Energy Technology Data Exchange (ETDEWEB)

    Hastings, C.R.

    1999-08-30

    In December 1998, the U.S. Department of Energy (DOE) published the ''Viability Assessment of a Repository at Yucca Mountain'' (DOE 1998b). The Viability Assessment described a preliminary design of a potential repository at Yucca Mountain, Nevada, for disposal of spent nuclear fuel and high-level radioactive waste, and assessed the probable behavior of that repository design in the Yucca Mountain geologic setting. The report concluded that 'Yucca Mountain remains a promising site for a geologic repository and that work should proceed to support a decision in 2001 on whether to recommend the site to the President for development as a repository'. It also concluded that 'uncertainties remain about key natural processes, the preliminary design, and how the site and design would interact'. Recognizing that the design that was evaluated will be refined before a license application could be submitted, the Viability Aassesment notes that 'DOE is evaluating several design options and alternatives that could reduce existing uncertainty and improve the performance of the repository system'. During the preparation of the Viability Assessment, DOE asked the contractor for the Civilian Radioactive Waste Management Program to study alternative design concepts for a potential geologic repository for high-level radioactive waste at Yucca Mountain. The License Application Design Selection (LADS) project was initiated to conduct that study. The goal of the project was to develop and evaluate a diverse range of conceptual repository designs that work well in concert with the Yucca Mountain site and to recommend an initial design concept for the possible Site Recommendation and License Apllication. This report presents the results of the LADS project. The design process consisted of two phases. In Phase I, a series of basic design concepts (design alternatives) and components (design features) were analyzed for their potential value

  20. Hydrotreater/Distillation Column Hazard Analysis Report Rev. 2

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, Peter P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wagner, Katie A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-04-15

    This project Hazard and Risk Analysis Report contains the results of several hazard analyses and risk assessments. An initial assessment was conducted in 2012, which included a multi-step approach ranging from design reviews to a formal What-If hazard analysis. A second What-If hazard analysis was completed during February 2013 to evaluate the operation of the hydrotreater/distillation column processes to be installed in a process enclosure within the Process Development Laboratory West (PDL-West) facility located on the PNNL campus. The qualitative analysis included participation of project and operations personnel and applicable subject matter experts. The analysis identified potential hazardous scenarios, each based on an initiating event coupled with a postulated upset condition. The unmitigated consequences of each hazardous scenario were generally characterized as a process upset; the exposure of personnel to steam, vapors or hazardous material; a spray or spill of hazardous material; the creation of a flammable atmosphere; or an energetic release from a pressure boundary.

  1. Transportation capabilities of the existing cask fleet

    International Nuclear Information System (INIS)

    This paper describes a number of scenarios estimating the amount of spent nuclear fuel that could be transported to a Monitored Retrievable Storage (MRS) Facility by various combinations of existing cask fleets. To develop the scenarios, the data provided by the Transportation System Data Base (TSDB) were modified to reflect the additional time for cask turnaround resulting from various startup and transportation issues. With these more realistic speed and cask-handling assumptions, the annual transportation capability of a fleet consisting of all of the existing casks is approximately 465 metric tons of uranium (MTU). The most likely fleet of existing casks that would be made available to the DOE consists of two rail, three overweight truck, and six legal weight truck casks. Under the same transportation assumptions, this cask fleet is capable of approximately transporting 270 MTU/year. These ranges of capability is a result of the assumptions pertaining to the number of casks assumed to be available. It should be noted that this assessment assumes additional casks based on existing certifications are not fabricated

  2. Collision avoidance for CTV: Requirements and capabilities

    Science.gov (United States)

    Nosek, Thomas P.

    Cargo transfer vehicle (CTV) operations near Space Station Freedom will require positive collision avoidance maneuver (CAM) capability to preclude any change of collision, even in the event of CTV failures. The requirements for CAM are discussed, and the CAM design approach and design of the Orbiting Maneuvering Vehicle (OMV) are reviewed; this design met requirements for OMV operation near the Space Station, provided a redundant collision avoidance maneuver capability. Significant portions of the OMV CAM design should be applicable to CTV. The key features of the OMV design are summarized and related to the CTV mission design to that of OMV's. CAM is a defined sequence of events executed by the CTV to place the vehicle in a safe position relative to a target such as the Space Station. CAM can be performed through software commands to the propulsion system, or through commands pre-stored in hardware. Various techniques for triggering CAM are considered, and the risks associated with CAM enable and execution in phases are considered. OMV CAM design features both hardware and software CAM capability, with analyses conducted to assess the ability to meet the collision-free requirement during all phases of the mission.

  3. 15 years of Rev Rene - a tribute to the Brazilian Nursing!

    OpenAIRE

    Alacoque Lorenzini Erdmann

    2016-01-01

    Congratulations to Rev Rene, Northeastern Nursing Network Journal (in Portuguese), for its fifteen years of existence consecrating important contributions to the science and profession of nursing. Congratulations to the Postgraduate Program in Nursing, to the Nursing Department and to the institution Federal University of Ceará that hosts this important structure of scientific dissemination.

  4. 15 years of Rev Rene - a tribute to the Brazilian Nursing!

    Directory of Open Access Journals (Sweden)

    Alacoque Lorenzini Erdmann

    2015-11-01

    Full Text Available Congratulations to Rev Rene, Northeastern Nursing Network Journal (in Portuguese, for its fifteen years of existence consecrating important contributions to the science and profession of nursing. Congratulations to the Postgraduate Program in Nursing, to the Nursing Department and to the institution Federal University of Ceará that hosts this important structure of scientific dissemination.

  5. 48 CFR 53.301-1415 - SF 1415 (Rev. 7/93) Consent of Surety and Increase of Penalty.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 1415 (Rev. 7/93) Consent of Surety and Increase of Penalty. 53.301-1415 Section 53.301-1415 Federal Acquisition Regulations...-1415 SF 1415 (Rev. 7/93) Consent of Surety and Increase of Penalty. EC01MY91.102...

  6. 78 FR 63964 - Request for Comments on Draft NIST Interagency Report (NISTIR) 7628 Rev. 1, Guidelines for Smart...

    Science.gov (United States)

    2013-10-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... (NISTIR) 7628 Rev. 1, Guidelines for Smart Grid Cyber Security AGENCY: National Institute of Standards and... Smart Grid Cyber Security. Draft NISTIR 7628 Rev. 1 was completed by the NIST-led Smart...

  7. Human-Centered Design Capability

    Science.gov (United States)

    Fitts, David J.; Howard, Robert

    2009-01-01

    For NASA, human-centered design (HCD) seeks opportunities to mitigate the challenges of living and working in space in order to enhance human productivity and well-being. Direct design participation during the development stage is difficult, however, during project formulation, a HCD approach can lead to better more cost-effective products. HCD can also help a program enter the development stage with a clear vision for product acquisition. HCD tools for clarifying design intent are listed. To infuse HCD into the spaceflight lifecycle the Space and Life Sciences Directorate developed the Habitability Design Center. The Center has collaborated successfully with program and project design teams and with JSC's Engineering Directorate. This presentation discusses HCD capabilities and depicts the Center's design examples and capabilities.

  8. Improving the RPC rate capability

    CERN Document Server

    Aielli, G; Cardarelli, R; Di Ciaccio, A; Di Stante, L; Iuppa, R; Liberti, B; Paolozzi, L; Pastori, E; Santonico, R; Toppi, M

    2016-01-01

    This paper has the purpose to study the rate capability of the Resistive Plate Chamber, RPC, starting from the basic physics of this detector. The effect of different working parameters determining the rate capability is analysed in detail, in order to optimize a new family of RPCs for applications to heavy irradiation environments and in particular to the LHC phase 2. A special emphasis is given to the improvement achievable by minimizing the avalanche charge delivered in the gas. The paper shows experimental results of Cosmic Ray tests, performed to study the avalanche features for different gas gap sizes, with particular attention to the overall delivered charge. For this purpose, the paper studies, in parallel to the prompt electronic signal, also the ionic signal which gives the main contribution to the delivered charge. Whenever possible the test results are interpreted on the base of the RPC detector physics and are intended to extend and reinforce our physical understanding of this detector.

  9. Horns Rev II, 2D-Model Tests

    DEFF Research Database (Denmark)

    Andersen, Thomas Lykke; Brorsen, Michael

    . The objective of the tests was to investigate the impact pressures generated on a horizontal platform and a cone platform for selected sea states calibrated by Lykke Andersen & Frigaard, 2006. The measurements should be used for assessment of slamming coefficients for the design of horizontal and cone......This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU), Denmark. The starting point for the present report is the previously carried out run-up tests described in Lykke Andersen & Frigaard, 2006......-shaped access platforms on piles. The Model tests include mainly regular waves and a few irregular wave tests. These tests have been conducted at Aalborg University from 9. November, 2006 to 17. November, 2006....

  10. Neurology check list. 5. rev. and enl. ed.; Checkliste Neurologie

    Energy Technology Data Exchange (ETDEWEB)

    Grehl, Holger [Evangelisches und Johanniter Klinikum, Duisburg (Germany). Neurologische Klinik; Reinhardt, Frank

    2013-02-01

    The neurology check list covers the following issues, organized in four parts: Grey part - diagnostic fundamentals, therapeutic principles: clinical neurological examination, liquor puncture, specific laboratory diagnostics, neurophysical diagnostics, imaging techniques, therapeutic principles, legal aspects, neurological assessment. Green Part - leading syndromes and leading symptoms. Blue part - neurological disease appearance: pains in head and face, pain syndrome, congenital and development disturbances, liquor circulation disturbances, ZNS hemorrhages, tumors and neoplasm, paraneoplastic syndromes, inflammatory diseases of the nervous system, dementia diseases, metabolic and other encephalopathy, cerebellum diseases and system surmounting processes, movement degeneration, basal ganglion diseases, epilepsy, non-epileptic attacks, medulla diseases, brain nerve diseases, plexus lesions, radicular lesions, peripheric neuropathy, neuromuscular transfer disturbances, muscular diseases. Red part: neurological intensive medicine.

  11. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2004-05-15

    Elsam and Eltra built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm off the Danish west coast. The wind farm is sited 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine was erected in May 2002 and the last wind turbine tower of a total of 80 was in place by August 2002. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production by December 2002. The expected impact of the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind turbine towers and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horns Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site-specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrate was conducted in March 2003 and in September 2003. This report describes the first year results of surveys on hard substrate after the completion of the offshore wind farm at Horns Rev. (au)

  12. Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration.

    Directory of Open Access Journals (Sweden)

    Aviad Levin

    Full Text Available BACKGROUND: The human immunodeficiency virus type 1 (HIV-1 integrase protein (IN, catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3'-end processing in which IN removes a pGT dinucleotide from the 3' end of each viral long terminal repeat (LTR. Following nuclear import of the viral preintegration complex, the host chromosomal DNA becomes accessible to the viral cDNA and the second step of the integration process, namely the strand-transfer step takes place. This ordered sequence of events, centered on integration, is mandatory for HIV replication. METHODOLOGY/PRINCIPAL FINDINGS: Using an integrase peptide library, we selected two peptides, designated INr-1 and INr-2, which interact with the Rev protein and probably mediate the Rev-integrase interaction. Using an in-vitro assay system, we show that INr-1 and INr-2 are able to abrogate the inhibitory effects exerted by Rev and Rev-derived peptides on integrase activity. Both INr-1 and INr-2 were found to be cell-permeable and nontoxic, allowing a study of their effect in HIV-1-infected cultured cells. Interestingly, both INr peptides stimulated virus infectivity as estimated by production of the viral P24 protein, as well as by determination of the appearance of newly formed virus particles. Furthermore, kinetics studies revealed that the cell-permeable INr peptides enhance the integration process, as was indeed confirmed by direct determination of viral DNA integration by real-time PCR. CONCLUSIONS/SIGNIFICANCE: The results of the present study raise the possibility that in HIV-infected cells, the Rev protein may be involved in the integration of proviral DNA by controlling/regulating the activity of the integrase. Release from such inhibition leads to stimulation of IN activity and multiple viral DNA integration events.

  13. Measuring IT Service Management Capability

    DEFF Research Database (Denmark)

    Wulf, Jochen; Winkler, Till J.; Brenner, Walter

    2015-01-01

    (CMMISVC, COBIT 4.1, SPICE, ITIL v3), we first develop a multi-attributive scale to assess maturity on an ITSM process level. We then use this scale in a survey with 205 ITSM key informants who assessed IT provider organizations along a set of 26 established ITSM processes. Our exploratory factor analysis...

  14. Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulation.

    Science.gov (United States)

    Rambaud, Juliette; Triqueneaux, Gérard; Masse, Ingrid; Staels, Bart; Laudet, Vincent; Benoit, Gérard

    2009-05-01

    Circadian rhythms are observed in nearly all aspects of physiology and behavior. In mammals, such biological rhythms are supported by a complex network of self-sustained transcriptional loops and posttranslational modifications, which regulate timely controlled production and degradation of critical factors on a 24-h basis. Among these factors, the orphan nuclear receptor rev-erbalpha plays an essential role by linking together positive and negative regulatory loops. As an essential part of the circadian core clock mechanism, REV-ERBalpha expression shows a precisely scheduled oscillation reflecting the tight control of its production and degradation. In previous studies, we identified two alternative transcripts encoding two protein variants referred to as REV-ERBalpha1 and -alpha2. Interestingly, recent work identified structural elements present only in REV-ERBalpha1 that controls its turnover and thereby influences circadian oscillations. In the present work, we comparatively analyze the two variants and show that REV-ERBalpha2 exhibits a half-life incompatible with a circadian function, suggesting that this variant exerts different biological functions. However, our comparative study clearly indicates undistinguishable DNA-binding properties and transcriptional repression activity as well as a similar regulation mechanism. The only consistent difference appears to be the relative expression level of the two transcripts, rev-erbalpha1 being one to 100 times more expressed than alpha2 depending on tissue and circadian time. Taking this finding into consideration, we reassessed REV-ERBalpha2 turnover and were able to show that this variant exhibits a reduced half-life when coexpressed with REV-ERBalpha1. We propose that the relative expression levels of the two REV-ERBalpha variants fine-tune the circadian period length by regulating REV-ERBalpha half-life. PMID:19228794

  15. National Ignition Facility risk management plan, rev. 1

    International Nuclear Information System (INIS)

    The initial release of the National Ignition Facility (AUF) Risk Management Plan (LLNL, 1997a) was prepared in accordance with the DOE Life Cycle Asset Management Good Practice Guide (DOE, 1996a) and supported Critical Decision 3 (CD3), Approval to Initiate Construction (DOE, 1997a). The objectives of the plan were to: (1) Identify the risks to the completion of the Project in terms of meeting technical and regulatory requirements, cost, and schedule. (2) Assess the risks in terms of likelihood of occurrence and their impact potential relative to technical performance, ES and H (environmental, safety and health), costs, and schedule. (3) Address suitable risk mitigation measures for each identified risk. This revision of the Risk Management Plan considers project risks and vulnerabilities after CD3 (DOE, 1997a) was approved by the Secretary of Energy. During the one-year period since the initial release, the vulnerabilities of greatest concern have been the litigation of the Programmatic Environmental Impact Statement (PEIS) (DOE, 1996b) by a group of environmental organizations led by the Natural Resources Defense Council; the finding and successful clean-up of polychlorinated biphenyl (PCB)-filled electrical capacitors at the NIF site excavation; the FY98 congressional budget authorization and request for the FY99 budget authorization; funding for Inertial Confinement Fusion (ICF)/NIF programmatic activities (including French and other sources of funding); and finally, progress in the core science and technology, and optics program that form the basis for the NIF design

  16. NASA DEVELOP Students Rev Up Response to Gulf Oil Spill

    Science.gov (United States)

    Jones, Jason B.; Childs, Lauren M.

    2010-01-01

    After the April 20th explosion aboard the Deepwater Horizon drilling rig in the Gulf of Mexico, the world witnessed one of the worst oil spill catastrophes in global history. In an effort to mitigate the disaster, the U.S. government moved quickly to establish a unified command for responding to the spill. Some of the command's most immediate needs were to track the movement of the surface oil slick, establish a baseline measurement of pre-oil coastal ecosystem conditions, and assess potential air quality and water hazards related to the spill. To help address these needs and assist the Federal response to the disaster, NASA deployed several of its airborne and satellite research sensors to collect an unprecedented amount of remotely-sensed data over the Gulf of Mexico region. Although some of these data were shared with the public via the media, much of the NASA data on the disaster was not well known to the Gulf Coast community. The need existed to inform the general public about these datasets and help improve understanding about how NASA's science research was contributing to oil spill response and recovery. With its extensive experience conducting community-oriented remote sensing projects and close ties to organizations around Gulf of Mexico, the NASA DEVELOP National Program stood in a unique position to meet this need.

  17. Offshore wind farms in the local community - a survey at Horns Rev wind farm. Background report; Havvindmoeller i lokalomraedet - en undersoegelse ved Horns Rev havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, S.

    2005-07-15

    This report is part of a socio-economic project about offshore wind farms' influence on the local community. The project is part of the monitoring programme in connection with the establishment of the offshore wind farms at Horns Rev and Nysted. The socio-economic project consists of a sociological and an environment-economic project. This report is part of the sociological project which has the purpose of identifying attitudes towards the wind farm before and after the erection with a view to identify possible changes in opinions and reasons for these changes. (BA)

  18. Longevity of Emplacement Drift Ground Support Materials, Rev. 01

    International Nuclear Information System (INIS)

    The purpose of this analysis is to evaluate the factors affecting the longevity of emplacement drift ground support materials and to develop a basis for the selection of materials for ground support that will function throughout the preclosure period of a potential repository at Yucca Mountain. The Development Plan (DP) for this analysis is given in Longevity of Emplacement Drift Ground Support Materials (CRWMS M and O 1999a). The objective of this analysis is to update the previous analysis (CRWMS M and O 2000a) to account for related changes in the Ground Control System Description Document (CRWMS M and O 2000b), the Monitored Geologic Repository Project Description Document (CRWMS M and O 1999b), and in environmental conditions, and to provide updated information on candidate ground support materials. Candidate materials for ground support are carbon steel and cement grout. Steel is mainly used for steel sets, lagging, channel, rock bolts, and wire mesh. Cement grout is only considered in the case of grouted rock bolts. Candidate materials for the emplacement drift invert are carbon steel and crushed rock ballast. Materials are evaluated for the repository emplacement drift environment based on the updated thermal loading condition and waste package design. The analysis consists of the following tasks: (1) Identify factors affecting the longevity of ground support materials for use in emplacement drifts; (2) Review existing documents concerning the behavior of candidate ground support materials during the preclosure period; (3) Evaluate impacts of temperature and radiation effects on mechanical and thermal properties of steel. Assess corrosion potential of steel at emplacement drift environment; (4) Evaluate factors affecting longevity of cement grouts for fully grouted rock bolt system. Provide updated information on cement grout mix design for fully grouted rock bolt system; and (5) Evaluate longevity of materials for the emplacement drift invert

  19. Climate change and the Lower Fraser Valley. rev. ed.

    International Nuclear Information System (INIS)

    The climatic changes that are expected to occur in British Columbia's Lower Fraser Valley over the next century were described in this report which included information about the science of climate change and the development of global climate models that provide estimates of global climate for the coming century. The confidence that scientists have in these models was reflected in the fact that most can simulate the important seasonal and geographical large scale features of the global climate, and that many of the large scale changes that are effected by greenhouse gas concentrations can be explained in terms of physical processes which operate around the world. The models also reproduce with reasonable accuracy the variations of climate such as the El Nino phenomena., the cooling due to the Mount Pinatubo eruption in 1991 and the global warming that occurred over the past 100 years. Three climate stations were analyzed in this study to assess the climate change of the Valley. Climatic change is influenced by increased concentrations of greenhouse gases in the atmosphere which in turn cause accelerated global warming. Scientists generally believe that the combustion of fossil fuels and other human activities are a major reason for the increased concentration of carbon dioxide. Plant respiration and the decomposition of organic matter releases 10 times more CO2 than that released anthropogenically, but these releases are in balance with plant photosynthesis. The rate of warming in the Lower Fraser Valley is uncertain, but climate models suggest it could be about 3 to 4 degrees warming with wetter winters and drier summers by the end of the century. The Valley currently has mild temperatures and high precipitation because of its proximity to the Pacific Oceans and the surrounding mountains. Global warming can have an impact on sea levels along the coast, spring flooding, summer drought, coastal ecosystems, air quality, occurrences of forest fires, and recreation

  20. Developing a dispersant spraying capability

    Energy Technology Data Exchange (ETDEWEB)

    Gill, S.D.

    1979-01-01

    In developing a national dispersant spraying capability, the Canadian Coast Guard (CCG) has undertaken a modification program to enable the conventional offshore spraying gear to be mounted on almost any vessel of convenience. Smaller, more versatile inshore spraying vessels and pumps have been designed and built. With the popularization of concentrated dispersants, the inshore pumping equipment can be used aboard hovercraft for special application situations. A program of acquiring mobile dispersant storage tanks has been undertaken with auxiliary equipment that will facilitate the shipment of dispersants in bulk by air freight. Work also has commenced on extending the dispersant application program to include the CCG fleet of helicopters.

  1. Production, innovation and service capabilities

    DEFF Research Database (Denmark)

    Slepniov, Dmitrij; Wæhrens, Brian Vejrum; Wu, Dong;

    2012-01-01

    Fragmentation and global dispersion are among the most prominent characteristics of contemporary operations. Not only routine transactional tasks, but also more knowledge-intensive proprietary tasks are subjected to this trend. As a result of this, complex configurations of assets and capabilities...... crossing both national and organisational borders emerge. The challenge of coordination in these configurations is an imperative which has not been adequately addressed so far. Therefore, by using explorative cases of Chinese and Danish companies, this paper seeks to develop a conceptual framework relating...

  2. Developing A/E Capabilities

    International Nuclear Information System (INIS)

    During the last few years, the methods used by EMPRESARIOS AGRUPADOS and INITEC to perform Architect-Engineering work in Spain for nuclear projects has undergone a process of significant change in project management and engineering approaches. Specific practical examples of management techniques and design practices which represent a good record of results will be discussed. They are identified as areas of special interest in developing A/E capabilities for nuclear projects . Command of these areas should produce major payoffs in local participation and contribute to achieving real nuclear engineering capabities in the country. (author)

  3. Construction and expression of a Rev-dependent TNF-R1 expressing HIV-infected-cell injurious vectors

    Institute of Scientific and Technical Information of China (English)

    SHI Wei-min; Dean Baylis; Damian Purcell; Paul U Cameron

    2005-01-01

    Background Rev is necessary for exporting unspliced and incompletely spliced intron containing HIV mRNAs and for HIV replication. The aim of this study is to develop a kind of selective suicide construct that can specifically and directly induce HIV infected cells into apoptosis based on the high affinity of Rev and Rev response element (RRE). Methods Molecular-cloning technique was used to synthesis Rev dependent TNF-R1 expression construct pDM128-TNF-R1 (pT128) that contains RRE and TNFR1 gene. Restriction digestion, Polymerase Chain Reaction (PCR) and DNA sequencing were processed and the exactness and correctness of the inserted TNF-R1 gene in pT128 were confirmed repeatedly. The expression of pT128 co-transfected with different combination of other plasmids by calcium phosphate-DNA co-precipitation in Helas and by gene gun transfection in keratinocytes was further tested by flow-cytometry and cell counted under microscope. Results The new plasmid specifically expressed TNF-R1 in Helas when co-transfected with pRev but did not when without pRev. Indirect expression of TNF-R1 from pT128 was slower than the direct expression of that from Hu p60 TNFR1 in pDC302 (pT60), but all those pT60 or pT128 transfected cells showed apoptosis at last while TNF-R1 was sufficiently expressed. Other kinds of Rev expression construct such as pAD8 and a chimeric HIV vaccine also can switched on the selective expression of pT128. Not only Rev-dependent expression in Helas, pT128 also normally expressed its TNF-R1 in keratinocytes. Co-transfected with pRev or pAD8 that expressed Rev, pT128 expressed TNF-R1 and induced apoptosis of green fluorescent keratinocytes in skin explant. The number of green fluorescent keratinocytes co-transfected by pT128 plus pRev or pAD8 was gradually outnumbered by that co-transfected by pT128 only. The difference was more significant after culturing for 72 hours. Conclusions Rev dependent pT128 is able to selectively induce apoptosis of HIV-infected or

  4. Assessment

    Institute of Scientific and Technical Information of China (English)

    Geoff Brindley

    2005-01-01

    @@ Introduction TERMINOLOGY AND KEY CONCEPTS The term assessment refers to a variety of ways of collecting information on a learner's language ability or achievement. Although testing and assessment are often used interchangeably, the latter is an umbrella term encompassing measurement instruments administered on a ‘one-off’ basis such as tests, as well as qualitative methods of monitoring and recording student learning such as observation, simulations of project work. Assessment is also distinguished from evaluation which is concerned with the overall language programme and not just with what individual students have learnt. Proficiency assessment refers to the assessment of general language abilities acquired by the learner independent of a course of study.This kind of assessment is often done through the administration of standardised commercial language-proficency tests. On the other hand, assessment of achievement aims to establish what a student had learned in relation to a particular course or curriculum (thus frequently carried out by the teacher) .Achievement assesssment may be based either on the specific content of the course or on the course objectives (Hughes 1989).

  5. Inspection of fire protection measures and fire fighting capability at nuclear power plants. A publication within the NUSS programme

    International Nuclear Information System (INIS)

    The present publication has been developed with the help of experts from regulatory, operating and engineering organizations, all with practical experience in the field of fire protection of nuclear power plants. The publication outlines practices for inspecting the fire protection measures at nuclear power plants in accordance with Safety Series No.50-SG-D2(Rev.1), Fire Protection in Nuclear Power Plants, and includes a comprehensive fire safety inspection checklist of the specific elements to be addressed when evaluating the adequacy and effectiveness of the fire protection measures and manual fire fighting capability available at operating nuclear power plants. The publication will be useful not only to regulators and safety assessors but also to operators and designers. The book addresses a specialized topic and it is recommended that it be used in conjunction with Safety Guide No.50-SG-D2(Rev.1)

  6. Impact of SME policies on innovation capabilities: The Turkish case

    OpenAIRE

    Elif Bascavusoglu-Moreau; Mustafa Colakoglu

    2011-01-01

    The purpose of this paper is to explore the determinants of innovative capabilities in an emerging country context. We focus more particularly on the impact of recent changes in SME policies in Turkey. Using a unique firm-level survey conducted on 45.000 SMEs, innovative capabilities of firms are assessed at three different levels; their innovation efforts, innovation decision and innovative intensity. We analyze and compare the impact of two different incentive schemes; one a purely financia...

  7. Advanced Simulation & Computing FY15 Implementation Plan Volume 2, Rev. 0.5

    Energy Technology Data Exchange (ETDEWEB)

    McCoy, Michel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Archer, Bill [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Matzen, M. Keith [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-09-16

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the surety and reliability of the U.S. nuclear stockpile. The SSP uses nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of experimental facilities and programs, and the computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources that support annual stockpile assessment and certification, study advanced nuclear weapons design and manufacturing processes, analyze accident scenarios and weapons aging, and provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balance of resource, including technical staff, hardware, simulation software, and computer science solutions. As the program approaches the end of its second decade, ASC is intently focused on increasing predictive capabilities in a three-dimensional (3D) simulation environment while maintaining support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (sufficient resolution, dimensionality, and scientific details), quantify critical margins and uncertainties, and resolve increasingly difficult analyses needed for the SSP. Where possible, the program also enables the use of high-performance simulation and computing tools to address broader national security needs, such as foreign nuclear weapon assessments and counternuclear terrorism.

  8. Reactor Pressure Vessel Fracture Analysis Capabilities in Grizzly

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, Benjamin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Backman, Marie [Univ. of Tennessee, Knoxville, TN (United States); Chakraborty, Pritam [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hoffman, William [Univ. of Idaho, Moscow, ID (United States)

    2015-03-01

    Efforts have been underway to develop fracture mechanics capabilities in the Grizzly code to enable it to be used to perform deterministic fracture assessments of degraded reactor pressure vessels (RPVs). Development in prior years has resulted a capability to calculate -integrals. For this application, these are used to calculate stress intensity factors for cracks to be used in deterministic linear elastic fracture mechanics (LEFM) assessments of fracture in degraded RPVs. The -integral can only be used to evaluate stress intensity factors for axis-aligned flaws because it can only be used to obtain the stress intensity factor for pure Mode I loading. Off-axis flaws will be subjected to mixed-mode loading. For this reason, work has continued to expand the set of fracture mechanics capabilities to permit it to evaluate off-axis flaws. This report documents the following work to enhance Grizzly’s engineering fracture mechanics capabilities for RPVs: • Interaction Integral and -stress: To obtain mixed-mode stress intensity factors, a capability to evaluate interaction integrals for 2D or 3D flaws has been developed. A -stress evaluation capability has been developed to evaluate the constraint at crack tips in 2D or 3D. Initial verification testing of these capabilities is documented here. • Benchmarking for axis-aligned flaws: Grizzly’s capabilities to evaluate stress intensity factors for axis-aligned flaws have been benchmarked against calculations for the same conditions in FAVOR. • Off-axis flaw demonstration: The newly-developed interaction integral capabilities are demon- strated in an application to calculate the mixed-mode stress intensity factors for off-axis flaws. • Other code enhancements: Other enhancements to the thermomechanics capabilities that relate to the solution of the engineering RPV fracture problem are documented here.

  9. Professionals and Public Good Capabilities

    Directory of Open Access Journals (Sweden)

    Melanie Walker

    2015-12-01

    Full Text Available Martha Nussbaum (2011 reminds us that, all over the world people are struggling for a life that is fully human - a life worthy of human dignity. Purely income-based and preference-based evaluations, as Sen (1999 argues, do not adequately capture what it means for each person to have quality of life. There are other things that make life good for a person, including access to publicly provided professional services. The question then is what version of education inflects more towards the intrinsic and transformational possibilities of professional work and contributions to decent societies? This paper suggests that we need a normative approach to professional education and professionalism; it is not the case that any old version will do. We also need normative criteria to move beyond social critique and to overcome a merely defensive attitude and to give a positive definition to the potential achievements of the professions. Moreover universities are connected to society, most especially through the professionals they educate; it is reasonable in our contemporary world to educate professional graduates to be in a position to alleviate inequalities, and to have the knowledge, skills and values to be able to do so. To make this case, we draw on the human capabilities approach of Sen (1999, 2009 and Nussbaum (2000, 2011 to conceptualise professional education for the public good as an ally of the struggles of people living in poverty and experiencing inequalities, expanding the well-being of people to be and to do in ways they have reason to value – to be mobile, cared for, respected, and so on. In particular we are interested in which human capabilities and functionings are most needed for a professional practice and professionalism that can contribute to transformative social change and how professional development is enabled via pedagogical arrangements.

  10. Administrative circular No. 20 (Rev. 2) – Use of private vehicules for journeys on official duty

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circular No. 20 (Rev. 2) entitled "Use of private vehicles for journeys on official duty", adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 January 2011, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 20 (Rev. 1) entitled "Use of private vehicles on official duty" of April 1993. This new version introduces, in particular, the payment of a kilometer allowance in case of emergency during standby duty or when on call and a simplified calculation of the allowance for journeys between sites. This circular also clarifies the type of permitted private vehicles. Department Head Office  

  11. Administrative circular n°23 (Rev. 3) – Special working hours

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 23 (Rev. 3) entitled “Special working hours”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to staff members and fellows. It cancels and replaces Administrative Circular No. 23 (Rev. 2) entitled “Special working hours” of December 2008. Paragraph 6 a) of Annex II of this circular was revised following the modification of Article III 1.04 of the Staff Regulations approved by Council on 14 December 2012. The modification serves to adapt the minimum rest time to the fact that, in case of rapidly alternating shifts, a maximum of seven consecutive shifts may be performed. Department Head Office HR Department

  12. Administrative circular n°11 (REV. 2) – Categories of members of the personnel

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 May 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department. This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 1) entitled “Categories of members of the personnel” of January 1997 as regards all contracts of members of the personnel issued on or after 1 January 2013. The circular was revised in order to take into account developments since the last revision of the categories of personnel in 1997 as well as the needs of the Organization and collaborating institutes. In particular, it introduces a new system for distinguishing categories of associated members of the personnel, namely with regard to the purpo...

  13. Administrative Circular No. 13 (Rev. 3) - Guarantees for representatives of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 13 (Rev. 3) entitled “Guarantees for representatives of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 13 (Rev. 2) entitled “Guarantees for members of the personnel holding representative office” of November 1992. The circular was revised in order to adapt the time given to the representatives of the personnel to perform their elective mandate and to ensure more transparency in their activities, by indicating, inter alia, the percentage of time worked in the framework of their mandate, as well as the training, activities and ensuing results. Department Head Office HR Department

  14. A Circular Motion Activity with Hot Wheels® Rev-Ups

    Science.gov (United States)

    Wagner, Glenn

    2009-02-01

    Hot Wheels® Rev-Ups provide a pedagogically engaging and inexpensive culminating activity for the application of circular motion with constant speed in introductory mechanics. The introductory Rev-Up, shown in Fig. 1, consists of a very durable car with two strong magnets built into the front and back of the car. The track is a piece of flexible plastic with a built-in metallic strip through its center that can then be formed into a circle. Pushing the car forward several times on a flat surface allows the car to move in a vertical circle when placed inside the track. What makes this toy attractive is that the gearing system allows the car to move at a relatively constant speed for about three to five seconds before slowing down appreciably.

  15. Administrative Cicular No. 31 (Rev. 2) - International indemnity and non-resident allowance

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 31 (Rev. 2) entitled "International indemnity and non-resident allowance", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 23 June 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208547.   This revised circular cancels and replaces Administrative Circular No. 31 (Rev. 1) also entitled "International indemnity and non-resident allowance" of October 2007. The main changes reflect the decision taken in the framework of the five-yearly review to extend eligibility for international indemnity to all staff members, as well to introduce a distinction between current staff members and those recruited as from 1st September 2016. For the latter, the international indemnity will be calculated as a percentage of the minimum salary of the grade into which they are recruited; the amount granted to the former will not change, and is now expressed ...

  16. RevPAR、收益管理与收益管理经理

    Institute of Scientific and Technical Information of China (English)

    王大悟

    2013-01-01

    一、RevPAR这是酒店业熟悉的指标,即每间可供出租客房的实际平均房价,以客房门市价与出租率的乘积得出。这个指标至少考量了出租率与房价两个重要因素的组合,单纯出租率和房价并不能科学反映酒店的经营业绩。因此到目前为止,RevPAR依然是衡量与比较酒店经营状况的一个标准。

  17. Administrative Circular No. 11 (Rev. 3) - Categories of members of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 11 (Rev. 3) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 3 July 2014 and entering into force on 1 September 2014, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel” of January 2013. The circular was revised in order to include a minor adjustment of the determination of required period of break in the payment of subsistence allowance to certain categories of associated members of the personnel (taking account of possible technical means of control). Furthermore, the possibility of traineeships of long duration was restricted to cases in which the traineeship is awarded pursuant to an agreement between CERN and a...

  18. Switching studies for the Horns Rev 2 wind farm main cable

    DEFF Research Database (Denmark)

    Jensen, Christian Flytkjær; Faria da Silva, Filipe; Bak, Claus Leth;

    2011-01-01

    sections with a total length of 57.7 km and a 42 km long submarine cable. The submarine cable is a three phase type of cable, and three single conductor cables are used for the land cable. Methods of recalculating the physical cable parameters, given in the data sheet, to parameters suitable for the cable......This article proposes a method of constructing a PSCAD model suitable for switching studies in a system containing long HVAC cables. The transmission network connection to the 215 MW offshore wind farm Horns Rev 2 is used as a case study. The connection to Horns Rev 2 consists of two land cable......, and the use of different cable models....

  19. Re(V) and Re(III) Complexes with Sal2phen and Triphenylphosphine: Rearrangement, Oxidation and Reduction

    OpenAIRE

    Lane, Stephanie Renee; Sisay, Nebiat; Carney, Brett; Dannoon, Shorouk; Williams, Stephen; Engelbrecht, Hendrik Petrus; Barnes, Charles Leslie; Jurisson, Silvia Sabine

    2010-01-01

    Reactions of ReV, tetradentate Schiff base complexes with tertiary phosphines have previously yielded both rearranged ReV and reduced ReIII complexes. To further understand this chemistry, the rigid diiminediphenol (N2O2) Schiff base ligand sal2phen (N,N’-o-phenylenebis(salicylaldimine)) was reacted with (n-Bu4N)[ReOCl4] to yield trans-[ReOCl(sal2phen)] (1). On reaction with triphenylphosphine (PPh3), a rearranged ReV product cis-[ReO(PPh3)(sal2phen*)]PF6 (2), in which one of the imines was r...

  20. Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα

    OpenAIRE

    Shogo Sato; Takuya Sakurai; Junetsu Ogasawara; Ken Shirato; Yoshinaga Ishibashi; Shuji Oh-ishi; Kazuhiko Imaizumi; Shukoh Haga; Yoshiaki Hitomi; Tetsuya Izawa; Yoshinobu Ohira; Hideki Ohno; Takako Kizaki

    2014-01-01

    It is now evident that many nuclear hormone receptors can modulate target gene expression. REV-ERBα, one of the nuclear hormone receptors with the capacity to alter clock function, is critically involved in lipid metabolism, adipogenesis, and the inflammatory response. Recent studies suggest that REV-ERBα plays a key role in the mediation between clockwork and inflammation. The purpose of the current study was to investigate the role of REV-ERBα in the regulation of interleukin-6 (il6) gene e...

  1. Power deficits due to wind turbine wakes at Horns Rev wind farm

    OpenAIRE

    Hansen, Kurt Schaldemose; Barthelmie, Rebecca; Jensen, Leo E.; Sommer, Anders

    2010-01-01

    The wind turbine operational charac-teristics, power measurements and the meteorological measurements as 10 minute statistical data from Horns Rev offshore wind farm have been identified, synchronized, quality screened and stored in a common database. A number of flow cases have been identified to describe the flow inside the wind farm and the flow deficits along rows of wind turbines have been determined for different inflow directions and wind speed intervals. Furthermore the maximum power ...

  2. Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

    OpenAIRE

    Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai; Réthoré, Pierre-Elouan

    2012-01-01

    We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stability conditions. This forms a basis for understanding of the blockage effects and their influence on wind farm production.

  3. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  4. Collaborative environments for capability-based planning

    Science.gov (United States)

    McQuay, William K.

    2005-05-01

    Distributed collaboration is an emerging technology for the 21st century that will significantly change how business is conducted in the defense and commercial sectors. Collaboration involves two or more geographically dispersed entities working together to create a "product" by sharing and exchanging data, information, and knowledge. A product is defined broadly to include, for example, writing a report, creating software, designing hardware, or implementing robust systems engineering and capability planning processes in an organization. Collaborative environments provide the framework and integrate models, simulations, domain specific tools, and virtual test beds to facilitate collaboration between the multiple disciplines needed in the enterprise. The Air Force Research Laboratory (AFRL) is conducting a leading edge program in developing distributed collaborative technologies targeted to the Air Force's implementation of systems engineering for a simulation-aided acquisition and capability-based planning. The research is focusing on the open systems agent-based framework, product and process modeling, structural architecture, and the integration technologies - the glue to integrate the software components. In past four years, two live assessment events have been conducted to demonstrate the technology in support of research for the Air Force Agile Acquisition initiatives. The AFRL Collaborative Environment concept will foster a major cultural change in how the acquisition, training, and operational communities conduct business.

  5. Stratification issues in the primary system. Review of available validation experiments and State-of-the-Art in modelling capabilities (StratRev)

    International Nuclear Information System (INIS)

    The objective of the present report is to review available validation experiments and State-of-the-Art in modelling of stratification and mixing in the primary system of Light Water Reactors. A topical workshop was arranged in Aelvkarleby in June 2008 within the framework of BWR-OG, and the presentations from various utilities showed that stratification issues are not unusual and can cause costly stops in the production. It is desirable to take actions in order to reduce the probability for stratification to occur, and to develop well-validated and accepted tools and procedures for analyzing upcoming stratification events. A research plan covering the main questions is outlined, and a few suggestions regarding more limited research activities are given. Since many of the stratification events results in thermal loads that are localized in time and space, CFD is a suitable tool. However, the often very large and complex geometry posses a great challenge to CFD, and it is important to perform a step-by-step increase in complexity with intermediate validation versus relevant experimental data. The ultimate goal is to establish Best Practice Guidelines that can be followed both by utilities and authorities in case of an event including stratification and thermal loads. An extension of the existing Best Practice Guidelines for CFD in nuclear safety applications developed by OECD/NEA is thus suggested as a relevant target for a continuation project. (au)

  6. Stratification issues in the primary system. Review of available validation experiments and State-of-the-Art in modelling capabilities (StratRev)

    Energy Technology Data Exchange (ETDEWEB)

    Westin, J.; Henriksson, M. (Vattenfall Research and Development AB (Sweden)); Paettikangas, T. (VTT (Finland)); Toppila, T.; Raemae, T. (Fortum Nuclear Services Ltd (Finland)); Kudinov, P. (KTH Nuclear Power Safety (Sweden)); Anglart, H. (KTH Nuclear Reactor Technology (Sweden))

    2009-08-15

    The objective of the present report is to review available validation experiments and State-of-the-Art in modelling of stratification and mixing in the primary system of Light Water Reactors. A topical workshop was arranged in AElvkarleby in June 2008 within the framework of BWR-OG, and the presentations from various utilities showed that stratification issues are not unusual and can cause costly stops in the production. It is desirable to take actions in order to reduce the probability for stratification to occur, and to develop well-validated and accepted tools and procedures for analyzing upcoming stratification events. A research plan covering the main questions is outlined, and a few suggestions regarding more limited research activities are given. Since many of the stratification events results in thermal loads that are localized in time and space, CFD is a suitable tool. However, the often very large and complex geometry posses a great challenge to CFD, and it is important to perform a step-by-step increase in complexity with intermediate validation versus relevant experimental data. The ultimate goal is to establish Best Practice Guidelines that can be followed both by utilities and authorities in case of an event including stratification and thermal loads. An extension of the existing Best Practice Guidelines for CFD in nuclear safety applications developed by OECD/NEA is thus suggested as a relevant target for a continuation project. (au)

  7. A comparative assessment of torque capabilities between lingual and labial brackets using three-dimension finite element%唇舌侧托槽转矩控制性能的有限元对比分析

    Institute of Scientific and Technical Information of China (English)

    黄思源; 周吉; 黄跃

    2016-01-01

    目的:分析唇舌侧托槽转矩控制性能的差异,同时探讨不同材质不同尺寸的弓丝对舌侧托槽转矩控制的影响规律。方法:建立左上尖牙到右上尖牙的唇舌侧托槽三维有限元模型,在弓丝尺寸及材质不同的情况下,模拟临床左上中切牙转矩加载±20°。结果:随着转矩角度的增大,唇舌侧托槽转矩值逐渐增大,舌侧托槽转矩值为唇侧托槽的3~5倍;0.48 mm ×0.64 mm 弓丝的转矩值大于0.43 mm ×0.64 mm;弓丝尺寸相同时,不锈钢丝(SS),β-钛丝(TMA),镍钛丝(NiTi),转矩值依次减小。结论:唇舌侧托槽转矩均随着转矩角度和弓丝的弹性模量的增大而增大;在相同的转矩角度下,舌侧托槽产生的转矩值大于唇侧托槽;舌侧托槽的转矩值与弓丝尺寸及材质有关。%Objective:To analyse the difference of torque performance between lingual and labial brackets as well as the influence of the archwires of different materials with different dimension on the torque capability of lingual brackets.Methods:The 3D finite mo-del of lingual and labial brackets from the right upper canine to the left upper canine was established,all brackets were with 0.56 mm slot size.The center of the bracket slot of the left upper central incisor was used as the central point and the two brackets were rotated clockwise and counterclockwise with a rotation angle of ±20°along the horizontal axis of bracket slot.The torque load on the left up-per central incisors with different materials and dimensions of the archwires was simulated.Results:The torque force of both lingual and labial brackets increased with the increase of rotation angle and the elastic modulus of archwire.The lingual archwire generated torque force was nearly 3 -5 times more than the labial system under the same torque angle.The torque value generated with 0.48 mm ×0.64 mm archwires was greater than 0.43 mm ×0.64 mm

  8. Capability assessment for application of clay mixture as barrier material for irradiated zirconium alloy structure elements long-term processing for storage during decommissioning of uranium-graphite nuclear reactors

    Science.gov (United States)

    Kotlyarevskiy, S. G.; Pavliuk, A. O.; Zakharova, E. V.; Volkova, A. G.

    2016-06-01

    The radionuclide composition and the activity level of the irradiated zirconium alloy E110, the radionuclide immobilization strength and the retention properties of the mixed clay barrier material with respect to the radionuclides identified in the alloy were investigated to perform the safety assessment of handling structural units of zirconium alloy used for the technological channels in uranium-graphite reactors. The irradiated zirconium alloy waste contained the following activation products: 93mNb and the long-lived 94Nb, 93Zr radionuclides. Radionuclides of 60Co, 137Cs, 90Sr, and actinides were also present in the alloy. In the course of the runs no leaching of niobium and zirconium isotopes from the E110 alloy was detected. Leach rates were observed merely for 60Co and 137Cs present in the deposits formed on the internal surface of technological channels. The radionuclides present were effectively adsorbed by the barrier material. To ensure the localization of radionuclides in case of the radionuclide migration from the irradiated zirconium alloy into the barrier material, the sorption properties were determined of the barrier material used for creating the long-term storage point for the graphite stack from uranium-graphite reactors.

  9. Tsunami disaster risk management capabilities in Greece

    Science.gov (United States)

    Marios Karagiannis, Georgios; Synolakis, Costas

    2015-04-01

    System, with the Greek NWTC actively participating as a Candidate Tsunami Watch Provider. In addition, Greece designed and conducted the first tsunami exercise program in the Union Civil Protection Mechanism in 2011, which also considered the attrition of response capabilities by the earthquake generating the tsunami. These exercises have demonstrated the capability of the Greek NWTC to provide early warning to local civil protection authorities, but warning dissemination to the population remains an issue, especially during the summer season. However, there is no earthquake or tsunami national emergency operations plan, and we found that tsunami disaster planning and preparedness activities are rather limited at the local level. We acknowledge partial support by the project ASTARTE (Assessment, STrategy And Risk Reduction for Tsunamis in Europe) FP7-ENV2013 6.4-3, Grant 603839 to the Technical University of Crete.

  10. Advanced Simulation Capability for Environmental Management: Development and Demonstrations - 12532

    International Nuclear Information System (INIS)

    The U.S. Department of Energy Office of Environmental Management (EM), Technology Innovation and Development is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of capabilities, which are organized into Platform and Integrated Tool-sets and a High-Performance Computing Multi-process Simulator. The Platform capabilities target a level of functionality to allow end-to-end model development, starting with definition of the conceptual model and management of data for model input. The High-Performance Computing capabilities target increased functionality of process model representations, tool-sets for interaction with Platform, and verification and model confidence testing. The new capabilities are demonstrated through working groups, including one focused on the Hanford Site Deep Vadose Zone. The ASCEM program focused on planning during the first year and executing a prototype tool-set for an early demonstration of individual components. Subsequently, ASCEM has focused on developing and demonstrating an integrated set of capabilities, making progress toward a version of the capabilities that can be used to engage end users. Demonstration of capabilities continues to be implemented through working groups. Three different working groups, one focused on EM problems in the deep vadose zone, another investigating attenuation mechanisms for metals and radionuclides, and a third focusing on waste tank performance assessment, continue to make progress. The project

  11. Dynamic Assessment of SME Cluster Innovation Capability---From Guangdong SME Clusters Based on Data 2009-2011%中小企业集群技术创新能力动态评估--基于广东2009-2011年数据

    Institute of Scientific and Technical Information of China (English)

    陈军; 侯飞; 孙曼林

    2015-01-01

    对中小企业集群的技术创新能力进行动态评估,有利于政府管理部门把握集群技术创新能力现状,完善技术创新政策,提高集群的技术创新能力,推动中小企业集群转型升级的顺利进行。通过构建集群技术创新能力评价指标体系,利用因子分析法对广东省20个地级市三年的技术创新能力进行动态评估并排序。结果发现:中小企业集群的技术创新能力处于动态变化中;政府的扶持是提升中小企业集群技术创新能力的重要因素;全面、科学分析各种因素并采取切实措施是提升中小企业集群技术创新能力的有效途径。要提高中小企业集群的技术创新能力,需要从技术人才的引进和培养、技术创新投入、技术创新平台建设、产学研合作等方面加大力度。%It can help government administration to grasp the status of cluster innovation capability , improve cluster innovation policy to improve the innovation capacity of the cluster ,and promote the transformation and upgrading of SME clusters smoothly of assessing the innovation capacity dy -namically of SMEs in Guangdong.It found that technological innovation capability of SME clusters change dynamically; government support is an important factor to enhance the technological innovation capability of SME clusters and should comprehensive analyze and scientific assess various factors to improve technological innovation capability .To improve the innovation capability majority of SME clusters , it needs to increase efforts in terms of the introduction and training of technical personnel, technical inputs, technology innovation platform, and research cooperation.

  12. Computers (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R

    1967-01-01

    This booklet relates how wires, transistors, and human ingenuity are combined to produce machines that surpass all the calculating prodigies that ever lived in speed, accuracy, and stamina, though perhaps not in the matter of mystery.

  13. Lasers (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Hellman, Hal

    1969-01-01

    A laser is an instrument that produces an enormously intense pencil-thin beam of light. In this booklet we shall learn what there is about the laser that gives it so much promise. We shall investigate what it is, how it works, and the different kinds of lasers there are.

  14. JEM/SMILES observation capability

    Science.gov (United States)

    Kasai, Yasuko J.; Baron, Philippe; Ochiai, Satoshi; Mendrok, Jana; Urban, Joachim; Murtagh, Donal; Moller, Joakim; Manabe, Takeshi; Kikuchi, Kenichi; Nishibori, Toshiyuki

    2009-09-01

    A new generation of sub-millimeter-wave receivers employing sensitive SIS (Superconductor-Insulator- Superconductor) detector technology will provide new opportunities for precise passive remote sensing observation of minor constituents in atmosphere. Superconducting Submillimeter-Wave Limb-Emission Sounder (SMILES) was designed to be onbord the Japanese Experiment Module (JEM) on the International Space Station (ISS) as a collaboration project of National Institute of Information and Communications Technology (NICT) and Japan Aerospace Exploration Agency (JAXA). SMILES scheduled to be launch in September 11, 2009 by the H-II Transfer Vehicle (HTV). Mission Objectives are: i) Space demonstration of superconductive mixer and 4-K mechanical cooler for the submillimeter limb emission sounding, and ii) global observations of atmospheric minor constituents. JEM/SMILES will allow to observe the atmospheric species such as O3, H35Cl, H37 Cl, ClO, BrO, HOCl, HO2, and HNO3, CH3CN, and Ozone isotope species with the precisions in a few to several tens percents from upper troposphere to the mesosphere. We have estimated the observation capabilities of JEM/SMILES. This new technology may allow us to open new issues in atmospheric science.

  15. Solar mechanics thermal response capabilities.

    Energy Technology Data Exchange (ETDEWEB)

    Dobranich, Dean D.

    2009-07-01

    In many applications, the thermal response of structures exposed to solar heat loads is of interest. Solar mechanics governing equations were developed and integrated with the Calore thermal response code via user subroutines to provide this computational simulation capability. Solar heat loads are estimated based on the latitude and day of the year. Vector algebra is used to determine the solar loading on each face of a finite element model based on its orientation relative to the sun as the earth rotates. Atmospheric attenuation is accounted for as the optical path length varies from sunrise to sunset. Both direct and diffuse components of solar flux are calculated. In addition, shadowing of structures by other structures can be accounted for. User subroutines were also developed to provide convective and radiative boundary conditions for the diurnal variations in air temperature and effective sky temperature. These temperature boundary conditions are based on available local weather data and depend on latitude and day of the year, consistent with the solar mechanics formulation. These user subroutines, coupled with the Calore three-dimensional thermal response code, provide a complete package for addressing complex thermal problems involving solar heating. The governing equations are documented in sufficient detail to facilitate implementation into other heat transfer codes. Suggestions for improvements to the approach are offered.

  16. OPSAID improvements and capabilities report.

    Energy Technology Data Exchange (ETDEWEB)

    Halbgewachs, Ronald D.; Chavez, Adrian R.

    2011-08-01

    Process Control System (PCS) and Industrial Control System (ICS) security is critical to our national security. But there are a number of technological, economic, and educational impediments to PCS owners implementing effective security on their systems. Sandia National Laboratories has performed the research and development of the OPSAID (Open PCS Security Architecture for Interoperable Design), a project sponsored by the US Department of Energy Office of Electricity Delivery and Energy Reliability (DOE/OE), to address this issue. OPSAID is an open-source architecture for PCS/ICS security that provides a design basis for vendors to build add-on security devices for legacy systems, while providing a path forward for the development of inherently-secure PCS elements in the future. Using standardized hardware, a proof-of-concept prototype system was also developed. This report describes the improvements and capabilities that have been added to OPSAID since an initial report was released. Testing and validation of this architecture has been conducted in another project, Lemnos Interoperable Security Project, sponsored by DOE/OE and managed by the National Energy Technology Laboratory (NETL).

  17. DC Brushless Motor Control Design and Preliminary Testing for Independent 4-Wheel Drive Rev-11 Robotic Platform

    Directory of Open Access Journals (Sweden)

    Roni Permana Saputra

    2012-03-01

    Full Text Available This paper discusses the design of control system for brushless DC motor using microcontroller ATMega 16 that will be applied to an independent 4-wheel drive Mobile Robot LIPI version 2 (REV-11. The control system consists of two parts which are brushless DC motor control module and supervisory control module that coordinates the desired command to the motor control module. To control the REV-11 platform, supervisory control transmit the reference data of speed and direction of motor to control the speed and direction of each actuator on the platform REV-11. From the test results it is concluded that the designed control system work properly to coordinate and control the speed and direction of motion of the actuator motor REV-11 platform. 

  18. WBN-1 Cycle 10 TPBAR Tritium Release, Deduced From Analysis of RCS Data TTP-1-3046-00, Rev 0

    Energy Technology Data Exchange (ETDEWEB)

    Shaver, Mark W.; Niehus, Mark T.; Love, Edward F.

    2012-02-19

    This document contains the calculation of the TPBAR tritium release from the Mark 9.2 design TPBARs irradiated in WBN cycle 10. The calculation utilizes the generalized cycle analysis methodology given in TTP-1-3045 Rev. 0.

  19. Revisão de Ceyxia Girault, stat. rev. (Hymenoptera, Chalcididae, Brachymeriini Revision of Ceyxia Girault, stat. rev. (Hymenoptera, Chalcididae, Brachymeriini

    Directory of Open Access Journals (Sweden)

    Tathiana Viana de Andrade

    2009-12-01

    Full Text Available O gênero Ceyxia Girault é revalidado e 27 espécies são combinadas a ele. Sete espécies previamente descritas são diagnosticadas (ou redescritas e discutidas, e 20 espécies novas são descritas. Ceyxia flaviscapus Girault, 1911 and C. ventrispinosa Girault, 1911 stat. rev. foram originalmente combinadas com Ceyxia e as seguintes são combinações novas: C. belfragei (Crawford, 1910 comb. nov., stat. rev.; C. concitator (Walker, 1862 comb. nov.; C. decreta (Walker, 1862 comb. nov.; C. dorsalis (Walker, 1861 comb. nov.; e C. villosa (Olivier, 1790 comb. nov. Ceyxia paraguayensis Girault, 1911 é consyiderada sinônimo júnior de Ceyxia flaviscapus Girault, 1911. As novas espécies são: C. acutigaster sp. nov.; C. amazonica sp. nov.; C. atuberculata sp. nov.; C. bellissima sp. nov.; C. dentiformis sp. nov.; C. diminuta sp. nov.; C. fusidentata sp. nov.; C. gibbosa sp. nov.; C. laminata sp. nov.; C. laticlipeata sp. nov.; C. latilabra sp. nov.; C. longiarticulata sp. nov.; C. longiscutellaris sp. nov.; C. longispina sp. nov.; C. nigropetiolata sp. nov.; C. paraensis sp. nov.; C. parvidentata sp. nov.; C. perparva sp. nov.; C. pseudovillosa sp. nov.; e C. tibiodilatata sp. nov. Dados sobre a associação com hospedeiros são apresentados para algumas espécies do gênero. Uma chave para as espécies do gênero é incluída.The genus Ceyxia Girault has its status revalidated and 27 species are assembled under it. Seven species previously described are diagnosed (or redescribed and discussed and 20 new species are described. Ceyxia flaviscapus Girault, 1911 and C. ventrispinosa Girault, 1911 stat. rev. were originally combined with Ceyxia and following are new combinations: C. belfragei (Crawford, 1910 comb. nov., stat. rev.; C. concitator (Walker, 1862 comb. nov.; C. decreta (Walker, 1862 comb. nov.; C. dorsalis (Walker, 1861 comb. nov.; and C. villosa (Olivier, 1790 comb. nov. Ceyxia paraguayensis Girault, 1911 is proposed as junior synonymy

  20. Status report of seabird surveys at Horns Rev, 2000-2001

    International Nuclear Information System (INIS)

    The present report presents the results of three bird surveys conducted in the Horns Rev area during the second half of 2001. Due to poor weather conditions in December 2001, the last survey was, however, performed on 7 January 2002. The surveys are part of the base-line investigations of birds performed in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. The results of the surveys during August 2001 - January 2002 are presented together with the results obtained during the period August 2000 - April 2001, and are also compared to results obtained during the period August 1999 - April 2000. Based on the distribution of the most abundant bird species recorded during 16 aerial surveys performed during August 1999 - January 2002, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, mainly occurring in the areas north and south of Horns Rev, and with low numbers on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common Scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although common scoter was found in relatively high numbers on the southeast slopes of the Horns Rev and within the wind farm area in the April 2001 survey. Common scoters occurred in very high numbers in January 2002. This was probably related to increased immigration of birds from the inner Danish waters during a cold period in late December 2001. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affect less than 1% of the various species, except divers where 1.58% will be

  1. Status report of seabird surveys at Horns Rev, 2000-2001

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [NERI, Dept. of Coastal Zone Ecology, Roskilde (Denmark)

    2002-07-01

    The present report presents the results of three bird surveys conducted in the Horns Rev area during the second half of 2001. Due to poor weather conditions in December 2001, the last survey was, however, performed on 7 January 2002. The surveys are part of the base-line investigations of birds performed in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. The results of the surveys during August 2001 - January 2002 are presented together with the results obtained during the period August 2000 - April 2001, and are also compared to results obtained during the period August 1999 - April 2000. Based on the distribution of the most abundant bird species recorded during 16 aerial surveys performed during August 1999 - January 2002, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, mainly occurring in the areas north and south of Horns Rev, and with low numbers on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common Scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although common scoter was found in relatively high numbers on the southeast slopes of the Horns Rev and within the wind farm area in the April 2001 survey. Common scoters occurred in very high numbers in January 2002. This was probably related to increased immigration of birds from the inner Danish waters during a cold period in late December 2001. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affect less than 1% of the various species, except divers where 1.58% will be

  2. A numerical-statistical approach to determining the representative elementary volume (REV) of cement paste for measuring diffusivity

    OpenAIRE

    Zhang, M. Z.; Ye, G.; van Breugel, K

    2010-01-01

    Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV), in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First,...

  3. CTL Responses to Regulatory Proteins Tat and Rev in HIV-1 B'/C Virus-Infected Individuals

    Institute of Scientific and Technical Information of China (English)

    MING-MING JIA; KUN-XUE HONG; JIAN-PING CHEN; HONG-WEI LIU; SHA LIU; XIAO-QING ZHANG; HONG-JING ZHAO; YI-MING SHAO

    2008-01-01

    To characterize HIV-1 specific CTL responses to regulatory proteins Tat and Rev in HIV-B'/C vires-infected ART-naive individuals. Methods HIV-1-specific CTL responses were analyzed by IFN-γ ELISPOT assay using overlapping peptides spanning the consensus sequences of HIV-1 clade C Tat and Rev proteins. Statistical analysis and graphical presentation were performed using SIGMAPLOT 10.0 and SIGMASTAT 3.5. For samples with a positive response, the magnitude of CTL responses was compared between HIV-1 C proteins by Wilcoxon rank sum test, and the significance threshold was P<0.05. Results Tat and Rev were frequently recognized, with 23% and 52% of the tested individuals having detectable responses to these proteins, respectively. Several immunodominant regions were detected in Rev. No significant correlation was observed between the magnitude and breadth of CTL responses to regulatory proteins and the control of virus replication in this study. Conclusion Tat and Rev can serve as targets for HIV-1-specific CTL, and several immunodominant regions are detectable in Rev. Further characterization of epitopes and their role in virus control may shed light on pathogenesis of HIV-1 natural infection and also be useful for the design and testing of candidate vaccines.

  4. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 3, Revision 2 (FGE.03Rev2): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated aldehydes, an ester of a hemiacetal and an orthoester of formic acid, from chemical groups 1, 2 and 4

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister;

    intake, estimated on the basis of the MSDI approach. Besides the safety assessment of this flavouring substance, the specifications for the materials of commerce have also been considered, and since the publication of FGE.03Rev1 additional information on chirality on 30 substances is made available...

  5. Organizational Economics of Capability and Heterogeneity

    DEFF Research Database (Denmark)

    Argyres, Nicholas S.; Felin, Teppo; Foss, Nicolai Juul;

    2012-01-01

    For decades, the literatures on firm capabilities and organizational economics have been at odds with each other, specifically relative to explaining organizational boundaries and heterogeneity. We briefly trace the history of the relationship between the capabilities literature and organizationa...

  6. Student Capabilities and Attitudes towards ICT in the Early Years

    Science.gov (United States)

    Sweeney, Trudy; Geer, Ruth

    2010-01-01

    This study investigated the use of information communication technologies (ICT) in the Early Years (R-3) in two diverse school settings. Students were surveyed to investigate their use of ICT at home and school. The findings presented, focus on student's self-assessed capabilities and attitudes using ICT and explore differences between the…

  7. Experiences with the Capability Maturity Model in a research environment

    NARCIS (Netherlands)

    Velden, van der M.J.; Vreke, J.; Wal, van der B.; Symons, A.

    1996-01-01

    The project described here was aimed at evaluating the Capability Maturity Model (CMM) in the context of a research organization. Part of the evaluation was a standard CMM assessment. It was found that CMM could be applied to a research organization, although its five maturity levels were considered

  8. Ecological Capability Assessment of Tabriz Suburb, Iran, for Urban Development using Multi Criteria Evaluation Approach. /Capacidad ecológica de los suburbios de la ciudad de Tabriz, Irán, para el desarrollo urbano utilizando la evaluación con criterios múltiples.

    Directory of Open Access Journals (Sweden)

    Naghdi, Farideh. Ranjbar, G.

    2009-12-01

    Full Text Available In order to achieve sustainable development, it is necessary to obtain and adopt planning procedures on the basis of Multi Criteria Evaluation of natural environment. Since biophysical (natural environment has limited ecological capabilities for human use, ecological capability assessment, as an essence for environmental studies and with the aim of preventing existing crises, yields proper grounds for environmental planning. The analysis of land capability and sufficiency for urban development is one of the main categories with which urban planners deal. In this paper, by means of Weighted Linear Combination (WLC through the perspective of Multi Criteria Evaluation (MCE Approach and within Geographic Information Systems (GIS, ecological capability of the suburbs surrounding Tabriz city was assessed (natural and human in terms of 12 criteria to examine physical development of Tabriz city and final mapping of the region was provided. This mapping shows regions suitable for physical urban development of the city. The results and finding of this research were applied by urban planners./Con el fin de lograr el desarrollo sostenible es necesario obtener y aprobar los procedimientos de planificación sobre la base de múltiples criterios de evaluación del medio ambiente natural. Desde lo biofísico (natural el ambiente ha limitado las capacidades ecológicas para el uso humano; la evaluación de las capacidades ecológicas es la esencia de los estudios ambientales y su objetivo es prevenir las crisis actuales, mostrando los rendimientos adecuados para la planificación ambiental. El análisis de la suficiencia y la capacidad de la tierra para el desarrollo urbano es una de las categorías principales a considerar por los planificadores urbanos. En este documento, por medio de la Combinación Lineal Ponderada (WLC, a través de la perspectiva de Múltiples Criterios de Evaluación (MCE y dentro de Enfoque de Sistemas de Información Geográfica (SIG

  9. Building capabilities to manage strategic alliances

    OpenAIRE

    SLUYTS, Kim; Matthyssens, Paul; Martens, Rudy; Streukens, Sandra

    2011-01-01

    Recently, academics have attributed a large part of alliance success to a firm's ability to successfully manage its alliances, also called its level of alliance management capability. We contribute to this growing body of literature by (1) verifying the impact of alliance management capability on alliance performance and (2) analyzing the drivers of alliance management capability. We measure this capability through four types of alliance learning processes and study how each of these processe...

  10. Work, Subjective Well-being and Capabilities

    OpenAIRE

    Suppa, Nicolai

    2014-01-01

    Chapter 2: This chapter explores the link between poverty as capability deprivation and current life satisfaction. Using German panel data, I examine both whether capability deprivation does hurt and whether individuals eventually adapt. To detect capability deprivation I draw on the notion of an inadequate income together with nonconsumption data of specific commodities. Assumptions and conditions rendering this approach valid are scrutinised. The results indicate that capability...

  11. A comprehensive estimation method for enterprise capability

    OpenAIRE

    Tetiana Kuzhda; Natalia Kyrych

    2015-01-01

    In today’s highly competitive business world, the need for efficient enterprise capability management is greater than ever. As more enterprises begin to compete on a global scale, the effective use of enterprise capability will become imperative for them to improve their business activities. The definition of socio-economic capability of the enterprise has been given and the main components of enterprise capability have been pointed out. The comprehensive method to estimate enterprise capabil...

  12. Sustainability economics, ontology and the capability approach

    OpenAIRE

    Martins, Nuno O.

    2011-01-01

    Copyright © 2011 Elsevier B.V. All rights reserved. The relationship between sustainability economics and the capability approach has recently been explored. Here I shall discuss this relationship, and argue that a study of the ontology underlying the capability approach can help us to see more clearly the interconnections between sustainability economics and the capability approach. In particular, the interpretations of the capability approach as an ontological exercise, which have recent...

  13. DESIGNING AND MEASURING CAPABILITY. A NEW PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Ovidiu COCENESCU

    2013-01-01

    Full Text Available The concept of capability has long been a topic for debate among planners. The main benefit brought by it is that of ensuring the connection between objectives and necessary financial resources. Thus, capability is a median element within the process of integrated planning. In this context, there are sceptics who consider that capability cannot be measured. However, this article aims at presenting a pattern and a formula for measuring and interpreting the level of capability.

  14. Capability development within the multinational corporation

    OpenAIRE

    Kilpinen, Paula

    2013-01-01

    The operating environment is being shaped by globalization forces, rapid technological change and intensified competition, which call for strategic changes and new capabilities from multinational corporations. Even though the capability-based determinants to firm survival and growth have been recognized, research on capability development has been limited. This study investigates capability dynamics within MNCs and the interactions between strategy and the environments internal and external t...

  15. Dynamic capabilities in small software firms

    OpenAIRE

    Kivelä, Marianne

    2007-01-01

    In this dissertation we study dynamic capabilities in small software firms. Small software firms find themselves in highly complex and turbulent environments that require dynamic capabilities to build, integrate and configure resources. While the literature describes a portfolio of such dynamic capabilities that can help firms to adapt to changing conditions, we could not find many definitions, models and studies on these capabilities suitable with particular focus on small software firms. Fu...

  16. Selecting Capabilities for Quality of Life Measurement

    Science.gov (United States)

    Robeyns, Ingrid

    2005-01-01

    The capability approach advocates that interpersonal comparisons be made in the space of functionings and capabilities. However, Amartya Sen has not specified which capabilities should be selected as the relevant ones. This has provoked two types of criticism. The stronger critique is Martha Nussbaum's claim that Sen should endorse one specific…

  17. Bird numbers and distributions in the Horns Rev offshore wind farm area. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Krag Petersen, I.

    2005-07-01

    This report presents data from four aerial surveys of birds in the Horns Rev wind farm area in 2004. Three surveys from the winter and spring of 2004 are thoroughly reported here. The fourth survey of 9 September 2004 is reported in general terms, but not included in presentations of distribution and effect analyses of the wind farm. Data from this survey will be thoroughly dealt with in a future report. Including the four surveys of 2004, a total of 29 surveys have been performed in that area since August 1999. (au)

  18. Pilot power based rate control in CDMA 2000 1x EV-DO Rev-A

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-feng; GU Jian; YANG Hong-wen

    2008-01-01

    This article proposes a new algorithm to improvethe rate control efficiency of enhanced reverse link mediumaccess control (RLMAC) in the code division multiple access(CDMA) lx EV-DO release A(Rev. A) system. The newalgorithm brings reverse access terminal (AT) pilot power tothe RLMAC rate control procedure and makes it easier for alow pilot power user to increase its data rate when the systemis slightly loaded and harder to decrease its date rate when thesystem is heavily loaded. Numerical results of system levelsimulations show that the new algorithm can bring highersystem throughput, lower AT transmission power, and lowersystem load.

  19. De novo mutations in PLXND1 and REV3L cause Möbius syndrome

    OpenAIRE

    Kayserili Karabey, Hülya; Tomas-Roca, Laura; Tsaalbi-Shtylik, Anastasia; Jansen, Jacob G.; Singh, Manvendra K.; Epstein, Jonathan A.; Altunoglu, Umut; Verzijl, Harriette; Soria, Laura; van Beusekom, Ellen; Roscioli, Tony; Iqbal, Zafar; Gilissen, Christian; Hoischen, Alexander; de Brouwer,Arjan P. M.; Erasmus, Corrie; Schubert, Dirk; Brunner, Han; Aytes, Antonio Perez; Marin, Faustino; Aroca, Pilar; Carta, Arturo; de Wind, Niels; Padberg, George W.; van Bokhoven, Hans

    2015-01-01

    ARTICLE Received 15 Nov 2014 | Accepted 17 Apr 2015 | Published 12 Jun 2015 De novo mutations in PLXND1 and REV3L cause Mo¨bius syndrome Laura Tomas-Roca1,2, Anastasia Tsaalbi-Shtylik3, Jacob G. Jansen3, Manvendra K. Singh4,5, Jonathan A. Epstein4, Umut Altunoglu6, Harriette Verzijl7, Laura Soria1, Ellen van Beusekom1, Tony Roscioli1,8, Zafar Iqbal1, Christian Gilissen1, Alexander Hoischen9, Arjan P.M. de Brouwer1, Corrie Erasmus7, Dirk Schubert10, Han Brunner1,11, Antoni...

  20. Fundamental study on REV based on crack tensor at the Mizunami Underground Research Laboratory

    International Nuclear Information System (INIS)

    The crack tensor model which is a kind of equivalent continuum model has been studied in rock mechanical investigation in the MIU. The fractured rock mass is modeled as the elastic continuum model with this crack tensor. In this study, this crack tensor based on the geological observation in the MIU project was calculated, and Representative Elementary Volume (REV) in the ventilation shaft and -300 m access/research gallery was studied based on the relative error of this crack tensor. As a result, the convergence of the relative error was faster in the -300 m access/research gallery than in the ventilation shaft. (author)

  1. Role of AtPolζ, AtRev1, and AtPolη in UV light-induced mutagenesis in Arabidopsis.

    Science.gov (United States)

    Nakagawa, Mayu; Takahashi, Shinya; Tanaka, Atsushi; Narumi, Issay; Sakamoto, Ayako N

    2011-01-01

    Translesion synthesis (TLS) is a DNA damage tolerance mechanism in which DNA lesions are bypassed by specific polymerases. To investigate the role of TLS activities in ultraviolet light-induced somatic mutations, we analyzed Arabidopsis (Arabidopsis thaliana) disruptants of AtREV3, AtREV1, and/or AtPOLH genes that encode TLS-type polymerases. The mutation frequency in rev3-1 or rev1-1 mutants decreased compared with that in the wild type, suggesting that AtPolζ and AtRev1 perform mutagenic bypass events, whereas the mutation frequency in the polh-1 mutant increased, suggesting that AtPolη performs nonmutagenic bypass events with respect to ultraviolet light-induced lesions. The rev3-1 rev1-1 double mutant showed almost the same mutation frequency as the rev1-1 single mutant. The increased mutation frequency found in polh-1 was completely suppressed in the rev3-1 polh-1 double mutant, indicating that AtPolζ is responsible for the increased mutations found in polh-1. In summary, these results suggest that AtPolζ and AtRev1 are involved in the same (error-prone) TLS pathway that is independent from the other (error-free) TLS pathway mediated by AtPolη.

  2. Distinctive Dynamic Capabilities for New Business Creation

    DEFF Research Database (Denmark)

    Rosenø, Axel; Enkel, Ellen; Mezger, Florian

    2013-01-01

    and fast-paced industries, and that similarities exist across industries. Hence, the study contributes to dynamic capabilities literature by: 1) identifying the distinctive dynamic capabilities for new business creation; 2) shifting focus away from dynamic capabilities in environments characterised by high...... clock-speed and uncertainty towards considering dynamic capabilities for the purpose of developing new businesses, which also implies a high degree of uncertainty. Based on interviews with 33 companies, we identify distinctive dynamic capabilities for new business creation, find that dynamic......This study examines the distinctive dynamic capabilities for new business creation in established companies. We argue that these are very different from those for managing incremental innovation within a company's core business. We also propose that such capabilities are needed in both slow...

  3. Activity-based resource capability modeling

    Institute of Scientific and Technical Information of China (English)

    CHENG Shao-wu; XU Xiao-fei; WANG Gang; SUN Xue-dong

    2008-01-01

    To analyse and optimize a enterprise process in a wide scope, an activity-based method of modeling resource capabilities is presented. It models resource capabilities by means of the same structure as an activity, that is, resource capabilities are defined by input objects, actions and output objects. A set of activity-based re-source capability modeling rules and matching rules between an activity and a resource are introduced. This method can not only be used to describe capability of manufacturing tools, but also capability of persons and applications, etc. It unifies methods of modeling capability of all kinds of resources in an enterprise and supports the optimization of the resource allocation of a process.

  4. High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.

    Directory of Open Access Journals (Sweden)

    Corinne Jud

    Full Text Available Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously synchronize themselves to the prevailing photoperiod by appropriate phase shifts. In this study, we disrupted two molecular components of the mammalian circadian oscillator, Rev-Erbalpha and Period1 (Per1. We found that mice lacking these genes displayed robust circadian rhythms with significantly shorter periods under constant darkness conditions. Strikingly, they showed high amplitude resetting in response to a brief light pulse at the end of their subjective night phase, which is rare in mammals. Surprisingly, Cry1, a clock component not inducible by light in mammals, became slightly inducible in these mice. Taken together, Rev-Erbalpha and Per1 may be part of a mechanism preventing drastic phase shifts in mammals.

  5. HRensembleHR. High resolution ensemble for Horns Rev. A project overview; Denmark

    Energy Technology Data Exchange (ETDEWEB)

    Moehrlen, C.; Joergensen, J.U. (Weprog ApS, Ebberup (DK)); Pinson, P.; Madsen, H. (DTU-IMM, Lyngby (DK)); Runge Kristoffersen, J. (Vattenfall A/S, Fredericia (DK))

    2008-07-01

    One of the major benefits of offshore wind power is a smoothing effect on the energy price, because it has it's own generation pattern with high average utilization, but also a more variable predictability for which ensemble predictions are designed. A Multi-Scheme Ensemble Prediction system (MSEPS) is used in this project to provide data to quantify the forecast uncertainty and develop new power prediction methods making use of the additional information contained in the ensemble data. In this first part of the project a 2.5 year simulation with the MSEPS has been carried out. The ensemble data was used to simulate a future scenario of 14GW wind power in the Northsea. For this purpose an algorithm based on ensemble predictions is introduced to upscale generation from 2 locations in the Northsea, the FINO1 platform and the Horns Rev wind farm. The validity of the algorithm and the error statistics of this future scenario are studied and compared to other sites and areas around the world. Additionally a new methodology for the power conversion with ensemble predictions is described and applied to the Horns Rev offshore wind farm. With this new algorithm the power curve is orthogonally fitted to have a better description of the 'true' power curve. A one year experiment has been carried out and compared to the classical least square minimisation. This results in ensemble forecasts that are more reliable in a probabilistic sense. (au)

  6. A BAC clone of MDV strain GX0101 with REV-LTR integration retained its pathogenicity

    Institute of Scientific and Technical Information of China (English)

    SUN AiJun; LAWRENCE Petherbridge; ZHAO YuGuang; LI YanPeng; NAIR Venugopal K; CUI ZhiZhong

    2009-01-01

    The complete genome of Marek's disease virus (MDV) strain GX0101,which was integrated with the LTR sequences of REV,was cloned in Escherichia coli as a bacterial artificial chromosome (BAC).BAC vector sequences were introduced into the US2 locus of the MDV genome by homologous recombination.The viral DNA containing the BAC vector was used to transform Escherichia coli strain of DH10B.Then the recombinant virus was successfully rescued by transfection of the recombinant BAC DNA into primary chicken embryo fibroblast (CEF).This BAC viral clone was named bac-GX0101.When the reconstituted virus was inoculated into 1-day-old birds,visceral tumors could be detected as early as 62 d post infection.There was no difference in growth ability and pathogenicity to birds between the BAC derived virus and its parental virus.The BAC derived virus maintained its oncogenicity and immunosuppressive effects.In conclusion,the complete genome of GX0101 strain was successfully cloned into BAC and the infectious clone was rescued.With the powerful BAC manipulation system,the infectious clone will provide a useful tool for further understanding the functional roles of the inserted REV-LTR sequence in the GX0101 strain of MDV.

  7. Revisiting the Fundamentals and Capabilities of the Stack Compression Test

    DEFF Research Database (Denmark)

    Alves, L.M.; Nielsen, Chris Valentin; Martin, P.A.F.

    2011-01-01

    of understanding for the stack compression test and to evaluate its capability for constructing the flow curves of metal sheets under high strains across the useful range of material testing conditions. The presentation draws from the fundamentals of the stack compression test to the assessment of its overall...... performance by comparing the flow curves obtained from its utilisation with those determined by means of compressive testing carried out on solid cylinder specimens of the same material. Results show that mechanical testing of materials by means of the stack compression test is capable of meeting...

  8. Development of a real-time quantitative RT-PCR to detect REV contamination in live vaccine.

    Science.gov (United States)

    Luan, Huaibiao; Wang, Yixin; Li, Yang; Cui, Zhizhong; Chang, Shuang; Zhao, Peng

    2016-09-01

    Based on the published Avian reticuloendotheliosis virus (REV) whole genome sequence, primers and TaqMan probes were designed and synthesized, and the TaqMan probe fluorescence real-time quantitative RT-PCR (qRT-PCR) method for detecting the REV pol gene was established by optimizing the reaction conditions. Sensitivity analysis showed that the qRT-PCR method had a sensitivity that was 1,000-fold higher than conventional PCR. Additionally, no amplification signals were obtained when we attempted to detect DNA or cDNA of ALV-A/B/J, MDV, CIAV, IBDV, ARV, NDV, AIV, or other viruses, suggesting a high specificity for our method. Various titers of REV were artificially "spiked" into the FPV and MDV vaccines to simulate REV contamination in attenuated vaccines to validate this qRT-PCR method. Our findings indicated that this qRT-PCR method could detect REV contamination at a dose of 1 TCID50/1,000 feathers, which was 10,000-fold more sensitive than the regular RT-PCR detection (10(4) TCID50/1000 feathers).

  9. An Assessment System for the System Safety Engineering Capability Maturity Model in the Case of Spent Fuel Reprocessing%一种乏燃料后处理系统安全工程能力成熟度评估系统

    Institute of Scientific and Technical Information of China (English)

    阳小华; 刘征海; 刘志明; 万亚平; 白小峰

    2012-01-01

    We can improve the processing, the evaluation of capability and promote the user's trust by using system security engineering capability maturity model (SSE-CMM) . SSE-CMM is the common method for organizing and implementing safety engineering, and it is a mature method for system safety en- gineering. Combining capability maturity model (CMM) with total quality management and statistic theo- ry, SSE-CMM turns systems security engineering into a well-defined, mature, measurable, advanced engi- neering discipline. Lack of domain knowledge, the size of data, the diversity of evidences, the cumber- someness of processes, and the complexity of matching evidences with problems are the main issues that SSE-CMM assessment has to face. To improve effectively the efficiency of assessment of spent fuel repro- cessing system security engineering capability maturity model (SFR-SSE-CMM), in this paper we de- signed an intelligent assessment software based on domain ontology and that uses methods such as ontology, evidence theory, semantic web, intelligent information retrieval and intelligent auto-matching techniques. This software includes four subsystems, which are domain ontology creation and management system, evi- dence auto collection system, and a problem and evidence matching system. The architecture of the soft- ware is divided into five layers: a data layer, an presentation layer. ontology layer, a knowledge layer, a service layer and a presentation layer.%SSE-CMM可用于过程改进、能力评估和提高用户的信任度,是组织和实施安全工程的通用方法,是系统安全工程领域成熟的方法体系。SSE-CMM结合了计算机科学中的CMM模型、管理学中的全面质量管理思想和统计理论,将系统安全工程转换为一个具有良好定义的、成熟的、可测量的先进工程学科。SSE-CMM评估面临领域知识缺乏、数据量大、证据类型多样、过程繁琐、证据与问题匹配复杂等

  10. Materials Capability Review Los Alamos National Laboratory April 29-May 2, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Antoinette J [Los Alamos National Laboratory

    2012-04-20

    Los Alamos National Laboratory (LANL) uses Capability Reviews to assess the quality and institutional integration of science, technology and engineering (STE) and to advise Laboratory Management on the current and future health of LANL STE. The capabilities are deliberately chosen to be crosscutting over the Laboratory and therefore will include experimental, theoretical and simulation disciplines from multiple line organizations. Capability Reviews are designed to provide a more holistic view of the STE quality, integration to achieve mission requirements, and mission relevance. The scope of these capabilities necessitate that there will be significant overlap in technical areas covered by capability reviews (e.g., materials research and weapons science and engineering). In addition, LANL staff may be reviewed in different capability reviews because of their varied assignments and expertise. The principal product of the Capability Review is the report that includes the review committee's assessments, recommendations, and recommendations for STE.

  11. Compilation of Sandia Laboratories technical capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Lundergan, C. D.; Mead, P. L. [eds.

    1975-11-01

    This report is a compilation of 17 individual documents that together summarize the technical capabilities of Sandia Laboratories. Each document in this compilation contains details about a specific area of capability. Examples of application of the capability to research and development problems are provided. An eighteenth document summarizes the content of the other seventeen. Each of these documents was issued with a separate report number (SAND 74-0073A through SAND 74-0091, except -0078). (RWR)

  12. Compilation of Sandia Laboratories technical capabilities

    International Nuclear Information System (INIS)

    This report is a compilation of 17 individual documents that together summarize the technical capabilities of Sandia Laboratories. Each document in this compilation contains details about a specific area of capability. Examples of application of the capability to research and development problems are provided. An eighteenth document summarizes the content of the other seventeen. Each of these documents was issued with a separate report number (SAND 74-0073A through SAND 74-0091, except -0078)

  13. Understanding dynamic capabilities through knowledge management

    DEFF Research Database (Denmark)

    Nielsen, Anders Paarup

    2006-01-01

    In the paper eight knowledge management activities are identified; knowledge creation, acquisition, capture, assembly, sharing, integration, leverage and exploitation. These activities are assembled into the three dynamic capabilities of knowledge development, knowledge (re......)combination and knowledge use. The dynamic capabilities and the associated knowledge management activities create flows to and from the firm’s stock of knowledge and they support the creation and use of organizational capabilities....

  14. Capabilities, social rights and European market integration

    OpenAIRE

    Jude Browne; Simon Deakin; Frank Wilkinson

    2002-01-01

    This paper explores the links between the economic notion of 'capabilities' and the judicial concept of social rights. We begin by revisiting TH Marshall's classic analysis of social rights and their ambiguous relationship to the market. We then examine how far Amartya Sen's Capabilities Approach provides a framework for locating social rights within a market setting. We argue that Sen's non-dogmatic, context-orientated approach to defining the meaning of capabilities offers a viable way forw...

  15. COMPLEMENTARITY OF INFORMATION TECHNOLOGY AND MARKETING CAPABILITIES

    OpenAIRE

    RAUL ALEXANDRU HUȚU

    2015-01-01

    This paper study the relation between information technology and marketing capabilities. The interface between marketing and information technology forms the subject of numerous empirical and conceptual research. The expanding adoption of information technology in marketing implies the knowledge about the e-marketing capabilities development factors and the potential of these capabilities to generate competitive advantage and to improve firm’s performance. The results of recent st...

  16. An Institutional View of Organizational Capabilities

    OpenAIRE

    Reinert do Nascimento, Mauricio; Bandeira-De-Mello, Rodrigo

    2008-01-01

    The literature of organizational capabilities has overlooked the role of values. We present an institutionalist view of the capability phenomenon accounting for the values occurring in three levels: in the action at routine level, at the organization level and at the institutional environment level. The mutual influences among these three levels are needed to analyze capability dynamics in its entirety. Central to our argument is the Weberian notion of social action and rationality, and the c...

  17. Explosive Effectiveness Capability (ExEC)

    Energy Technology Data Exchange (ETDEWEB)

    Nakafuji, G.; Daily, L.; Leake, J.

    2000-07-26

    Gaining accurate predictions of damage inflicted by high explosive devices is vital in order to minimize collateral damage effects on a target. ExEC provides a means for conducting very detailed analysis of weapons effects on targets for advanced mission planning purposes. ExEC is composed of a suite of high fidelity physics codes, which have been used for decades by the nuclear weapons laboratories for assessing high explosive, thermal, and structural effects. The ExEC capability should not be confused with the fast running empirical codes MEA and MEVA, which are good for fast scoping analysis. MEA and MEVA rely on look-up tables or simple approximations to quickly obtain a rough estimate of weapon damage on a target. In contrast, the ExEC capability provides a much higher fidelity damage prediction and a limitless number of target configurations by solving the time dependent conservation equations for mass, momentum, and energy, in order to directly simulate the interaction of a weapon with a target component. In contrast, MEA/MEVA must be calibrated for every different weapon type and target. ExEC has produced accurate simulations for weapon disablement, shape charge penetration, sympathetic detonation, fragment damage effects, and blast effects. For example, ExEC was used to look at a DTRA test performed at White Sands Missile Range, Dipole Orbit 1 (DO1). In DO1, a BLU-109 bomb was statically detonated in a partially buried four-room building that was storing chemical and biological weapon simulants, as well as inactive equipment typical of a CBW (Chemical and Biological Warfare) facility. The blast wave (overpressure) histories were recorded and compared to an ExEC and MEVA simulation. A direct comparison between experimental data and calculations, for a single pressure gauge, indicated that MEVA had a 200% error compared to 5% for ExEC. In addition, ExEC tracks the time dependant fluctuations in pressure (for an accurate prediction of the impulse), while MEVA

  18. Aerodynamics Laboratory Facilities, Equipment, and Capabilities

    Data.gov (United States)

    Federal Laboratory Consortium — The following facilities, equipment, and capabilities are available in the Aerodynamics Laboratory Facilities and Equipment (1) Subsonic, open-jet wind tunnel with...

  19. Esourcing capability model for service providers

    CERN Document Server

    Hefley, Keith M Heston and Bill; Hyder, Elaine

    2010-01-01

    The eSourcing Capability Model for Service Providers (eSCM-SP) is the best practices model that supports sourcing organizations successfully manage and reduce their risks and improve their capabilities across the entire sourcing life-cycle. It addresses the critical issues related to IT-enabled sourcing (eSourcing) for both outsourced and in-sourced (shared services) agreements. Each of the Model's 84 Practice is distributed along three easy to follow dimensions: Sourcing Life-cycle, Capability Area, and Capability Level, and have been applied in IT, BPO, and KPO settings.The eSCM-SP has been

  20. Methods of ecological capability evaluation of forest

    International Nuclear Information System (INIS)

    In this research common methods of ecological capability evaluation of forests were reviewed and limitations for performance were analysed. Ecological capability of forests is an index that show site potential in several role of wood production, soil conservation, flood control, biodiversity, conservation and water supply. This index is related to ecological characteristics of land, such as soil, micro climate, elevation, slope and aspect that affect potential of sites. Suitable method of ecological capability evaluation must be chosen according to the objective of forestry. Common methods for ecological capability evaluation include plant and animal diversity, site index curve, soil and land form, inter branches, index plants, leave analyses, analyses regeneration and ecological mapping

  1. Organizational Capabilities of the Entrepreneurial University

    Directory of Open Access Journals (Sweden)

    Lucian Gramescu

    2015-05-01

    Full Text Available Developing entrepreneurial capabilities has become a key competitiveness strategy in business across the world. Overall, organizational capabilities can provide performance improvements by taking an integrated approach to people, infrastructure and processes as means of codifying organizational learning. The paper proposes “organizational capability” as a valuable tool for universities who seek to develop their competitiveness entrepreneurially, especially across the EU, where higher education is no longer a guarantee for employment and alternatives are sorely needed. For this purpose, we explore conceptualizations of organizational capabilities, propose an integrative model and apply it to learn more about the development of capability from practice at Aalto University in Finland.

  2. Predictive Capability Maturity Model for computational modeling and simulation.

    Energy Technology Data Exchange (ETDEWEB)

    Oberkampf, William Louis; Trucano, Timothy Guy; Pilch, Martin M.

    2007-10-01

    The Predictive Capability Maturity Model (PCMM) is a new model that can be used to assess the level of maturity of computational modeling and simulation (M&S) efforts. The development of the model is based on both the authors experience and their analysis of similar investigations in the past. The perspective taken in this report is one of judging the usefulness of a predictive capability that relies on the numerical solution to partial differential equations to better inform and improve decision making. The review of past investigations, such as the Software Engineering Institute's Capability Maturity Model Integration and the National Aeronautics and Space Administration and Department of Defense Technology Readiness Levels, indicates that a more restricted, more interpretable method is needed to assess the maturity of an M&S effort. The PCMM addresses six contributing elements to M&S: (1) representation and geometric fidelity, (2) physics and material model fidelity, (3) code verification, (4) solution verification, (5) model validation, and (6) uncertainty quantification and sensitivity analysis. For each of these elements, attributes are identified that characterize four increasing levels of maturity. Importantly, the PCMM is a structured method for assessing the maturity of an M&S effort that is directed toward an engineering application of interest. The PCMM does not assess whether the M&S effort, the accuracy of the predictions, or the performance of the engineering system satisfies or does not satisfy specified application requirements.

  3. Administrative Circular No. 2 (Rev. 7) - Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    2015-01-01

    Administrative Circular No. 2 (Rev. 7), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion at the Standing Concertation Committee meeting held on 17 February 2015 is available via the following link: AC No. 2 (Rev.7).   This revised circular cancels and replaces Administrative Circular No. 2 (Rev. 6), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" and dated January 2015. The circular was revised in order to implement the amendment to Article R II 1.17 of the Staff Regulations, which introduces the possibility of extending limited-duration (LD) contracts up to a maximum total duration of eight years from the previous duration of five years. The award of indefinite contracts will continue to be subject to the outcome of a competitive process. Department Head Of...

  4. Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

  5. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

    Directory of Open Access Journals (Sweden)

    Wesselingh Steven L

    2007-07-01

    Full Text Available Abstract Background The Sydney blood bank cohort (SBBC of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1. Although the cohort members have experienced differing clinical courses and now comprise slow progressors (SP as well as long-term nonprogressors (LTNP, longitudinal analysis of nef/long-terminal repeat (LTR sequences demonstrated convergent nef/LTR sequence evolution in SBBC SP and LTNP. Thus, the in vivo pathogenicity of attenuated HIV-1 strains harboured by SBBC members is dictated by factors other than nef/LTR. Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36. Results The ability of Rev derived from D36 and C64 to bind the Rev responsive element (RRE in RNA binding assays was reduced by approximately 90% compared to Rev derived from HIV-1NL4-3, C18 or C98. D36 Rev also had a 50–60% reduction in ability to express Rev-dependent reporter constructs in mammalian cells. In contrast, C64 Rev had only marginally decreased Rev function despite attenuated RRE binding. In D36 and C64, attenuated RRE binding was associated with rare amino acid changes at 3 highly conserved residues; Gln to Pro at position 74 immediately N-terminal to the Rev activation domain, and Val to Leu and Ser to Pro at positions 104 and 106 at the Rev C-terminus, respectively. In D36, reduced Rev function was mapped to an unusual 13 amino acid extension at the Rev C-terminus. Conclusion These findings provide new genetic and mechanistic insights important for Rev function, and suggest that Rev function, not Rev/RRE binding may be rate limiting for HIV-1 replication. In addition, attenuated rev alleles may contribute to viral attenuation and long-term survival of HIV-1 infection in a subset of SBBC members.

  6. Do Acquirer Capabilities Affect Acquisition Performance? Examining Strategic and Effectiveness Capabilities in Acquirers

    OpenAIRE

    Mudde, Paul A.; Brush, Thomas

    2006-01-01

    This paper examines acquisition performance from the perspective of acquirer capabilities. It argues that the strategic capabilities underpinning a firm’s competitive strategy can be utilized to create economic value in acquisitions. Acquirers with strong cost leadership capabilities are expected to leverage these capabilities to reduce post-acquisition costs as they integrate acquisition targets. Acquirers with strong differentiation capabilities are expected to utilize their strategic capab...

  7. Administrative circular No. 2 (Rev. 5) – Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 1 September 2011, is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 2 (Rev. 4) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2009. Department Head Office

  8. Comments on Phys. Rev. D89 (2014) 097101 "Reevaluation of the parton distribution of strange quarks in the nucleon"

    CERN Document Server

    Stolarski, M

    2014-01-01

    The HERMES collaboration in Phys. Rev. D89 (2014) 097101 extracted information about the strange quark density in the nucleon. One of the main results is an observation that the shape of the extracted density is very different from the shapes of the strange quark density from global QCD fits and also from that of the light antiquarks. In this paper systematic studies on the HERMES published multiplicity of pion and kaon data are presented. It is shown that the conclusions concerning the strange quark distribution in the nucleon reached in Phys. Rev. D89 (2014) 097101 are at the moment premature.

  9. Methodological Individualism and the Organizational Capabilities Approach

    DEFF Research Database (Denmark)

    Felin, Teppo; Foss, Nicolai Juul

    2004-01-01

    critical individual-levelconsiderations, including individual action and heterogeneity. In this note we do not denyor reject the notion of routines or capabilities per se, but rather call for an increasedemphasis on how these collective structures originate and change as a result of individualactions.......Key words: Organizational capabilities, methodological individualism, philosophy ofsocial science...

  10. A framework for offshore vendor capability development

    Science.gov (United States)

    Yusuf Wibisono, Yogi; Govindaraju, Rajesri; Irianto, Dradjad; Sudirman, Iman

    2016-02-01

    Offshore outsourcing is a common practice conducted by companies, especially in developed countries, by relocating one or more their business processes to other companies abroad, especially in developing countries. This practice grows rapidly owing to the ease of accessing qualified vendors with a lower cost. Vendors in developing countries compete more intensely to acquire offshore projects. Indonesia is still below India, China, Malaysia as main global offshore destinations. Vendor capability is among other factors that contribute to the inability of Indonesian vendor in competing with other companies in the global market. Therefore, it is essential to study how to increase the vendor's capability in Indonesia, in the context of global offshore outsourcing. Previous studies on the vendor's capability mainly focus on capabilities without considering the dynamic of capabilities due to the environmental changes. In order to be able to compete with competitors and maintain the competitive advantage, it is necessary for vendors to develop their capabilities continuously. The purpose of this study is to develop a framework that describes offshore vendor capability development along the client-vendor relationship stages. The framework consists of three main components, i.e. the stages of client-vendor relationship, the success of each stage, and the capabilities of vendor at each stage.

  11. Knowledge Perspectives on Advancing Dynamic Capability

    NARCIS (Netherlands)

    van Reijsen, J.

    2014-01-01

    Dynamic Capability is the organizational capacity to timely adapt to a changing market environment by reconfiguring resources and routines in order to stay competitive. Although dynamic capability is considered the Holy Grail of strategic management, a connection to the knowledge management domain i

  12. Capability Development in an Offshoring Context

    DEFF Research Database (Denmark)

    Jaura, Manya

    in the offshore unit. Guided by the research question – what drives or impedes capability development in an offshoring context – the purpose of this thesis is to investigate how an idiosyncratic offshoring context affects capability development. The thesis consists of three papers using various datasets...

  13. Marketing capabilities: do they matter in INVs?

    OpenAIRE

    Blesa Pérez, Andreu; Ripollés Meliá, María; Monferrer Tirado, Diego

    2010-01-01

    This paper examines the influence that marketing capabilities developed in international new ventures can have on their international performance and international geographical diversification. Rapid entry in foreign markets is also highlighted as a factor contributing to the development of marketing capabilities in international new ventures. The central concept advanced in the paper is that international new ventures generate competitive advantages associated with early internationalisation...

  14. Cultivating Human Capabilities in Venturesome Learning Environments

    Science.gov (United States)

    Hogan, Padraig

    2013-01-01

    The notion of competencies has been a familiar feature of educational reform policies for decades. In this essay, Padraig Hogan begins by highlighting the contrasting notion of capabilities, pioneered by the research of Amartya Sen and Martha Nussbaum. An educational variant of the notion of capabilities then becomes the basis for exploring…

  15. Organizational Capabilities of the Entrepreneurial University

    OpenAIRE

    Lucian Gramescu; Nicolae Bibu

    2015-01-01

    Developing entrepreneurial capabilities has become a key competitiveness strategy in business across the world. Overall, organizational capabilities can provide performance improvements by taking an integrated approach to people, infrastructure and processes as means of codifying organizational learning. The paper proposes “organizational capability” as a valuable tool for universities who seek to develop their competitiveness entrepreneurially, especially across the EU, where hig...

  16. Modified multivariate process capability index using principal component analysis

    Science.gov (United States)

    Zhang, Min; Wang, G. Alan; He, Shuguang; He, Zhen

    2014-03-01

    The existing research of process capability indices of multiple quality characteristics mainly focuses on nonconforming of process output, the concept development of univariate process capability indices, quality loss function and various comprehensive evaluation methods. The multivariate complexity increases the computation difficulty of multivariate process capability indices(MPCI), which makes them hard to be used in practice. In this paper, a new PCA-based MPCI approach is proposed to assess the production capability of the processes that involve multiple product quality characteristics. This approach first transforms the original quality variables into standardized normal variables. MPCI measures are then provided based on the Taam index. Moreover, the statistical properties of these MPCIs, such as confidence intervals and lower confidence bound, are given to let the practitioners understand the capability indices as random variables instead of deterministic variables. A real manufacturing data set and a synthetic data set are used to demonstrate the effectiveness of the proposed method. An implementation procedure is also provided for quality engineers to apply our MPCI approach in their manufacturing processes. The case studies demonstrate the effectiveness and feasibility of this new kind of MPCI, which is easier to be used in production practice. The proposed research provides a novel approach of MPCI calculation.

  17. Developing Technological Capabilities in Agro-Industry

    DEFF Research Database (Denmark)

    Whitfield, Lindsay

    2012-01-01

    This article examines the emergence and trajectory of a new agro-industry in Ghana, the pineapple export industry, using the technological capabilities approach. It explains the limited expansion of the industry and its declining competitiveness in the face of new competition by looking at how Gh...... broader implications for developing new agro-industries in Ghana as well as other African countries.......This article examines the emergence and trajectory of a new agro-industry in Ghana, the pineapple export industry, using the technological capabilities approach. It explains the limited expansion of the industry and its declining competitiveness in the face of new competition by looking at how...... Ghanaian exporters developed technological capabilities initially and the incentives and disincentives to building on those capabilities. The article argues that at the heart of the industry's crisis was an inability to further develop technological capabilities. The crisis had systemic features that have...

  18. STRATEGIC AIRLIFT CAPABILITY: FROM THEORY TO PRACTICE

    Directory of Open Access Journals (Sweden)

    Cezar VASILESCU

    2011-01-01

    Full Text Available Strategic airlift remains a critical supporting capability that should be achieved, maintained and improved. This capability ensures the ability to deploy and sustain military forces across possible distant battlefields. The paper analyses the growing strategic airlift capabilities gap between operational needs and current realities, and underlines the need for an enhanced strategic airlift capability to meet current and future NATO alliance needs. By analyzing requirements against the existing/potential solutions, this paper further ponders over options like the organic national capability, partnerships such as the Strategic Airlift Consortium (SAC or leasing aircraft through a venture such as the Strategic Airlift Interim Solution (SALIS. The paper also evaluates the feasibility of applying these solutions to European Union airlift needs.

  19. Capabilities and Equality of Health II

    DEFF Research Database (Denmark)

    Keiding, Hans

    capability approach to questions of health or equality. In the present paper we extend the notion of rationalizing orderings of capabilities to a dynamical context, in the sense that the utility function is not yet revealed to the individual at the time when the capabilities are ordered. It turns out that......The concept of capabilities, introduced originally by Sen, has inspired many researchers but has not found any simple formal representation which might be instrumental in the construction of a comprehensive theory of equality. In a previous paper (Keiding, 2005), we investigated whether preferences...... over capabilities as sets of functionings can be rationalized by maximization of a suitable utility function over the set of functionings. Such a rationalization turned out to be possible only in cases which must be considered exceptional and which do not allowfor interesting applications of the...

  20. Réalisation par coulage en barbotine de revêtements anti-usure

    OpenAIRE

    Sonney, Vincent; Bidaux, Jacques-Eric; Carreño-Morelli, Efraín

    2009-01-01

    Objectifs : Réalisation d’un revêtement anti-usure. Il s’agira dans un premier temps, de développer par technologie des poudres un alliage superélastique en CuAlNi. Les propriétés tribologiques sont en outre mesurées et la possibilité d’y ajouter des renforts céramiques est abordée. Dans un deuxième temps, la mise en forme par élaboration d’une barbotine à base de cuivre est étudiée. Deux utilisations de cette barbotine sont exécutées : le coulage en bande et le trempage. Résultats : Plusieur...

  1. OPERATIONAL CIRCULAR No. 4 (REV. 1) – USE OF VEHICLES BELONGING TO OR RENTED BY CERN

    CERN Multimedia

    2012-01-01

    Operational Circular No. 4 (Rev. 1) entitled “Use of vehicles belonging to or rented by CERN”, approved by the Director-general following discussion in the Standing Concertation Committee meeting of 15 February 2012, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 4 entitled “Conditions for use by members of the CERN personnel of vehicles belonging to or rented by CERN” of April 2003. This new version enables, in particular, to include CERN contractors and their personnel, to harmonize the structure of the circular with other circulars and to simplify the procedures by permitting electronics forms. Department Head Office HR Department

  2. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    International Nuclear Information System (INIS)

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

  3. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp These Circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover in particular lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you require any additional informa...

  4. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://https://hr-docs.web.cern.ch/hr-docs/admincirc/admincirc_fr.asp These circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover, in particular, lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you requi...

  5. Indledende undersøgelser af Wave Star lokaliteten ved Horns Rev

    DEFF Research Database (Denmark)

    Kramer, Morten

    Havområdet ved Horns Rev havvindmøllepark er, pga. tilslutningsmulighederne for el, egnet til udbygning med et eller flere demonstrationsanlæg baseret på bølgekraft. Nærværende rapport beskriver detaljerede undersøgelser vedr. placering af den næste skala 1:2 maskine af Wave Star på lokaliteten....... Formålet med nærværende skrift er at beskrive bølgerne på lokaliteten mht. bølgehøjde, -periode og -retning, at estimere årsproduktionen fra en skala 1:2 Wave Star maskine og forventet orientering af maskinen for maksimal årsproduktion samt at vurdere de største bølger i samspil med vandstand som kan...

  6. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels.

  7. Numerical Modelling of Large-Diameter Steel Piles at Horns Rev

    DEFF Research Database (Denmark)

    Augustesen, Anders Hust; Brødbæk, K. T.; Møller, M.;

    2009-01-01

    Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used as founda......Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used...... as foundation for a wind turbine at Horns Rev located in the Danish sector of the North Sea. The outer diameter of the pile is 4 m and the subsoil at the location consists primarily of sand. The behaviour of the pile is investigated under realistic loading conditions by means of a traditional Winkler...

  8. Evaluation and Improvement of Shipbuilding Capability of China

    OpenAIRE

    Ye Feng; Zeng Guang-wu; Wang Yu

    2013-01-01

    There are many thorny problems in our country, such as the security of sea lanes. To deal with these problems, China needs to develop sophisticated naval force, and warship industry is the key factor to improve Chinese navy. Chinese warship industrial capacity is evaluated by using the assessment system. According to the results and existing researches, strategies for improving Chinese shipbuilding industry capability is built from five aspects. It is the reference to strengthen Chinese warsh...

  9. The atmospheric release advisory capability (ARAC): A federal emergency response capability

    International Nuclear Information System (INIS)

    The Atmospheric Release Capability (ARAC) is a Department of Energy (DOE)-sponsored emergency-response service set up to provide real-time prediction of the dose levels and the extent of surface contamination resulting from a broad range of possible occurrences (accidents, spills, extortion threats involving nuclear material, reentry of nuclear-powered satellites, and atmospheric nuclear tests) that could involve the release of airborne radioactive material. During the past decade, ARAC has responded to more than 150 real-time situations, including exercises. The most notable responses include the Three Mile Island accident in Pennsylvania, the Titan II missile accident in Arkansas, the reentry of the USSR's COSMOS-954 into the atmosphere over Canada, the accidental release of uranium hexafluoride from the Sequoyah Facility accident in Oklahoma, and, most recently, the Chernobyl reactor accident in the Soviet Union. ARAC currently supports the emergency-preparedness plans at 50 Department of Defense (DOD) and DOE sites within the US and also responds to accidents that happen elsewhere. Our ARAC center serves as the focal point for data acquisition, data analysis and assessments during a response, using a computer-based communication network to acquire real-time weather data from the accident site and the surrounding region, as well as pertinent accident information. Its three-dimensional computer models for atmospheric dispersion, MATHEW and ADPIC, digest all this information and produce the predictions used in accident assessment. 9 refs., 6 figs., 1 tab

  10. Building Technological Capability within Satellite Programs in Developing Countries

    Science.gov (United States)

    Wood, Danielle Renee

    Global participation in space activity is growing as satellite technology matures and spreads. Countries in Africa, Asia and Latin America are creating or reinvigorating national satellite programs. These countries are building local capability in space through technological learning. They sometimes pursue this via collaborative satellite development projects with foreign firms that provide training. This phenomenon of collaborative satellite development projects is poorly understood by researchers of technological learning and technology transfer. The approach has potential to facilitate learning, but there are also challenges due to misaligned incentives and the tacit nature of the technology. Perspectives from literature on Technological Learning, Technology Transfer, Complex Product Systems and Product Delivery provide useful but incomplete insight for decision makers in such projects. This work seeks a deeper understanding of capability building through collaborative technology projects by conceiving of the projects as complex, socio-technical systems with architectures. The architecture of a system is the assignment of form to execute a function along a series of dimensions. The research questions explore the architecture of collaborative satellite projects, the nature of capability building during such projects, and the relationship between architecture and capability building. The research design uses inductive, exploratory case studies to investigate six collaborative satellite development projects. Data collection harnesses international field work driven by interviews, observation, and documents. The data analysis develops structured narratives, architectural comparison and capability building assessment. The architectural comparison reveals substantial variation in project implementation, especially in the areas of project initiation, technical specifications of the satellite, training approaches and the supplier selection process. The individual

  11. CTH reference manual : composite capability and technologies.

    Energy Technology Data Exchange (ETDEWEB)

    Key, Christopher T.; Schumacher, Shane C.

    2009-02-01

    The composite material research and development performed over the last year has greatly enhanced the capabilities of CTH for non-isotropic materials. The enhancements provide the users and developers with greatly enhanced capabilities to address non-isotropic materials and their constitutive model development. The enhancements to CTH are intended to address various composite material applications such as armor systems, rocket motor cases, etc. A new method for inserting non-isotropic materials was developed using Diatom capabilities. This new insertion method makes it possible to add a layering capability to a shock physics hydrocode. This allows users to explicitly model each lamina of a composite without the overhead of modeling each lamina as a separate material to represent a laminate composite. This capability is designed for computational speed and modeling efficiency when studying composite material applications. In addition, the layering capability also allows a user to model interlaminar mechanisms. Finally, non-isotropic coupling methods have been investigated. The coupling methods are specific to shock physics where the Equation of State (EOS) is used with a nonisotropic constitutive model. This capability elastically corrects the EOS pressure (typically isotropic) for deviatoric pressure coupling for non-isotropic materials.

  12. Community psychology and the capabilities approach.

    Science.gov (United States)

    Shinn, Marybeth

    2015-06-01

    What makes for a good life? The capabilities approach to this question has much to offer community psychology, particularly with respect to marginalized groups. Capabilities are freedoms to engage in valued social activities and roles-what people can do and be given both their capacities, and environmental opportunities and constraints. Economist Amartya Sen's focus on freedoms and agency resonates with psychological calls for empowerment, and philosopher Martha Nussbaum's specification of requirements for a life that is fully human provides an important guide for social programs. Community psychology's focus on mediating structures has much to offer the capabilities approach. Parallels between capabilities, as enumerated by Nussbaum, and settings that foster positive youth development, as described in a National Research Council Report (Eccles and Gootman (Eds) in Community programs to promote youth development. National Academy Press, Washington, 2002) suggest extensions of the approach to children. Community psychologists can contribute to theory about ways to create and modify settings to enhance capabilities as well as empowerment and positive youth development. Finally, capabilities are difficult to measure, because they involve freedoms to choose but only choices actually made or enacted can be observed. The variation in activities or goals across members of a setting provides a measure of the capabilities that the setting fosters.

  13. Towards an Organizational Economics of Heterogeneous Capabilities

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul

    The notion of “capability” has long been influential in management research as an approach to address firm-level heterogeneity and heterogeneity in competitive outcomes. I discuss how recent advances in economics may allow for a more rigorous understanding and measurement of capability that take ...... organizational practices into account. However, economists may also learn from work on capabilities in management research.......The notion of “capability” has long been influential in management research as an approach to address firm-level heterogeneity and heterogeneity in competitive outcomes. I discuss how recent advances in economics may allow for a more rigorous understanding and measurement of capability that take...

  14. A Capability Approach for the European Union

    OpenAIRE

    Eiffe, Franz F.

    2008-01-01

    The aim of this paper is to develop a new concept for the EU in order to define and measure poverty no longer on the basis of income1, but on so called capabilities to argue for a capability oriented social policy. The capability approach (CA) was originally developed by Nobel laureate Amartya Sen2 and can be interpreted as critique of the utilitarian tradition of standard economics. In Sen's view, mainstream economic analysis operates on a very narrow base and does not include central inform...

  15. 75 FR 32493 - NUREG-0654/FEMA-REP-, Rev. 1, Supplement 3, Guidance for Protective Action Recommendations for...

    Science.gov (United States)

    2010-06-08

    ... SECURITY Federal Emergency Management Agency NUREG-0654/FEMA-REP-, Rev. 1, Supplement 3, Guidance for... Federal Emergency Management Agency (FEMA) and the Nuclear Regulatory Commission (NRC) are reopening the... jointly by the Nuclear Regulatory Commission (NRC) and the Federal Emergency Management Agency (FEMA)...

  16. 78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

    Science.gov (United States)

    2013-05-13

    ... listed drug was withdrawn from sale for reasons of safety or effectiveness (21 CFR 314.162). A person may... time after the drug has been withdrawn from sale, but must be made prior to approving an ANDA that... HUMAN SERVICES Food and Drug Administration Determination That REV-EYES (Dapiprazole...

  17. 77 FR 30546 - Notice of Proposed Information Collection: Comment Request; Form HUD-40221(rev) “LOCCS/VRS Self...

    Science.gov (United States)

    2012-05-23

    ...) ``LOCCS/VRS Self-Help Homeownership Opportunity Program Payment Voucher'' AGENCY: Office of the Assistant... Payment Voucher'' prior to requesting a drawdown of funds through LOCCS/VRS. Title of Proposal: Form HUD-40221(rev) ``LOCCS/VRS Self-help Homeownership Opportunity Program Payment Voucher''. OMB Control...

  18. OPERATIONAL CIRCULAR NO2 (REV. 1) - APRIL 1998 'CONDITIONS OF ACCESS TO THE FENCED PARTS OF THE CERN SITE'

    CERN Multimedia

    Human Resources Division

    2001-01-01

    Subsidiary document 'Implementation Measures' (Rev. 2) - April 2001 The subsidiary document has been amended. Copies are available from Divisional Secretariats and at CERN card issue points. Note : Administrative and operational circulars, as well as the lists of those in force, are available for consultation on WWW : ADMINISTRATIVE CIRCULARS OPERATIONAL CIRCULARS

  19. The calculational VVER burnup Credit Benchmark No.3 results with the ENDF/B-VI rev.5 (1999)

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Gual, Maritza [Centro de Tecnologia Nuclear, La Habana (Cuba). E-mail: mrgual@ctn.isctn.edu.cu

    2000-07-01

    The purpose of this papers to present the results of CB3 phase of the VVER calculational benchmark with the recent evaluated nuclear data library ENDF/B-VI Rev.5 (1999). This results are compared with the obtained from the other participants in the calculations (Czech Republic, Finland, Hungary, Slovaquia, Spain and the United Kingdom). The phase (CB3) of the VVER calculation benchmark is similar to the Phase II-A of the OECD/NEA/INSC BUC Working Group benchmark for PWR. The cases without burnup profile (BP) were performed with the WIMS/D-4 code. The rest of the cases have been carried with DOTIII discrete ordinates code. The neutron library used was the ENDF/B-VI rev. 5 (1999). The WIMS/D-4 (69 groups) is used to collapse cross sections from the ENDF/B-VI Rev. 5 (1999) to 36 groups working library for 2-D calculations. This work also comprises the results of CB1 (obtained with ENDF/B-VI rev. 5 (1999), too) and CB3 for cases with Burnup of 30 MWd/TU and cooling time of 1 and 5 years and for case with Burnup of 40 MWd/TU and cooling time of 1 year. (author)

  20. Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ.

    Science.gov (United States)

    Yoon, Jung-Hoon; Park, Jeseong; Conde, Juan; Wakamiya, Maki; Prakash, Louise; Prakash, Satya

    2015-12-15

    Translesion synthesis (TLS) DNA polymerases (Pols) promote replication through DNA lesions; however, little is known about the protein factors that affect their function in human cells. In yeast, Rev1 plays a noncatalytic role as an indispensable component of Polζ, and Polζ together with Rev1 mediates a highly mutagenic mode of TLS. However, how Rev1 functions in TLS and mutagenesis in human cells has remained unclear. Here we determined the role of Rev1 in TLS opposite UV lesions in human and mouse fibroblasts and showed that Rev1 is indispensable for TLS mediated by Polη, Polι, and Polκ but is not required for TLS by Polζ. In contrast to its role in mutagenic TLS in yeast, Rev1 promotes predominantly error-free TLS opposite UV lesions in humans. The identification of Rev1 as an indispensable scaffolding component for Polη, Polι, and Polκ, which function in TLS in highly specialized ways opposite a diverse array of DNA lesions and act in a predominantly error-free manner, implicates a crucial role for Rev1 in the maintenance of genome stability in humans. PMID:26680302