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Sample records for assessing double acid-etched

  1. Correlation between ISQ and Insertion Torque values using double acid-etched implants

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    Sebastián Gallardo

    2016-12-01

    Full Text Available Aim The purpose of this study was threefold: (1 to consider whether there was a correlation between stability quotient values (ISQ and insertion torque values (IT at implant placement (2; to determine which of these values were more related to success or failure; and (3 to determine the influence of bone type and implant length, diameter and shape in the study results. Materials and methods A retrospective clinical study was carried out between June 2012 and June 2014. The insertion torque and resonance frequency values of 279 double achid etched implants (Osseotite, Biomet 3i, Implant Innovations Inc., Palm Beach Gardens, USA, with conical and parallel walls, and of different diameters and lengths, were tested at the moment of insertion in 90 patients of different age (18-82 years of age/ average: 60.89 years and of both genders (58 females and 32 males. Collected data were processed and subjected to statistical analysis. Results The mean ISQ value was 70.54, showing no statistical significance between successful and unsuccessful implants. The mean IT value was 44.18. In this case, the values obtained showed a difference between successful and unsuccessful implants, yet not statistically significant (p> 0.05. However, statistically significant differences were found in relation to bone type, shape and length of the implants in IT as well as ISQ values. In the former case (IT values, the differences were only related to diameter. Conclusion There was a correlation between ISQ and IT values; with no significant difference concerning success or failure. The variables analyzed showed statistical differences, except for diameter, which was only significant for IT.

  2. In Vivo Assessment of Bone Ingrowth Potential of Three-Dimensional E-Beam Produced Implant Surfaces and the Effect of Additional Treatment by Acid Etching and Hydroxyapatite Coating

    NARCIS (Netherlands)

    Biemond, J.E.; Hannink, G.; Jurrius, A.M.G.; Verdonschot, Nicolaas Jacobus Joseph; Buma, P.

    2012-01-01

    The bone ingrowth potential of three-dimensional E-beam-produced implant surfaces was examined by histology and compared to a porous plasma-sprayed control. The effects of acid etching and a hydroxyapatite (HA) coating were also evaluated by histology. Specimens were implanted in the distal femur of

  3. Effect of acid etching of glass ionomer cement surface on the microleakage of sandwich restorations

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    Álvaro Della Bona

    2007-06-01

    Full Text Available The purposes of this study were to evaluate the sealing ability of different glass ionomer cements (GICs used for sandwich restorations and to assess the effect of acid etching of GIC on microleakage at GIC-resin composite interface. Forty cavities were prepared on the proximal surfaces of 20 permanent human premolars (2 cavities per tooth, assigned to 4 groups (n=10 and restored as follows: Group CIE - conventional GIC (CI was applied onto the axial and cervical cavity walls, allowed setting for 5 min and acid etched (E along the cavity margins with 35% phosphoric acid for 15 s, washed for 30 s and water was blotted; the adhesive system was applied and light cured for 10 s, completing the restoration with composite resin light cured for 40 s; Group CIN - same as Group CIE, except for acid etching of the CI surface; Group RME - same as CIE, but using a resin modified GIC (RMGIC; Group RMN - same as Group RME, except for acid etching of the RMGIC surface. Specimens were soaked in 1% methylene blue dye solution at 24ºC for 24 h, rinsed under running water for 1 h, bisected longitudinally and dye penetration was measured following the ISO/TS 11405-2003 standard. Results were statistically analyzed by Kruskal-Wallis and chi-square tests (a=0.05. Dye penetration scores were as follow: CIE - 2.5; CIN - 2.5; RME - 0.9; and RMN - 0.6. The results suggest that phosphoric acid etching of GIC prior to the placement of composite resin does not improve the sealing ability of sandwich restorations. The RMGIC was more effective in preventing dye penetration at the GIC-resin composite-dentin interfaces than CI.

  4. Clinical experience with the acid-etch technique in orthodontics.

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    Retief, D H; Sadowsky, P L

    1975-12-01

    The acid-etch technique and the development of improved composite resin systems have made the direct bonding of orthodontic attachments an accepted clinical procedure. This technique can be used with confidence as an adjunct in the armamentarium of the orthodontist.

  5. Assessment of the Effect of CO2 Laser Irradiation on the Reduction of Bacteria Seeded on Commercially Available Sandblasted Acid-Etched Titanium Dental Implants: An In Vitro Study.

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    Ferreira, Cimara Fortes; Babu, Jegdish; Migliorati, Erica Krohn Jany; Stein, Sydney; Garcia-Godoy, Franklin

    2015-01-01

    To evaluate the capability of carbon dioxide (CO₂) laser in reducing Escherichia coli on sandblasted acid-etched (SAE) titanium dental implants. SAE dental implants were contaminated with E coli, incubated in a sterile bacterial culture medium for 24 hours, and then exposed to CO₂ laser (10,600-nm wavelength) in superpulsed waves (SPW) at 1.5, 1.7, and 2 W at 100-Hz frequency and continuous wave (CW) at 1.5, 2, and 2.5 W. The presence of bacteria trapped in the implant surfaces after contamination and decontamination was verified using spectrophotometry. Scanning electron microscopy (SEM) was used to evaluate the topography of laser irradiation. After implant surface contamination was verified, implants were exposed to CO₂ laser irradiation, and bacterial growth was measured with spectrophotometry. The control implants showed the highest bacterial growth (100% growth). Implants exposed to laser showed progressive increase in the percentage of decontamination (DC%) corresponding to the higher wattage in the SPW and CW groups. The DC% were 20.4%, 49.6%, and 51.7% in the SPW group at 100 Hz, at 1.5, 1.7, and 2 W of power, respectively. In the CW group, the DC% were 34.3%, 69.9%, and 85.5% at 1.7, 2, and 2.5 W, respectively. Kruskal-Wallis statistical analysis showed a significant difference between the groups (P laser wattage increased. CO₂ laser irradiation failed to completely decontaminate the implant surfaces. SEM analysis demonstrated damage to the top of the dental implant threads at all settings studied. Thus, CO₂ laser irradiation may not be the optimal method to decontaminate implants.

  6. Effects of 401’. Phosphoric Acid Etch on the Compressive Strength of Biodentine

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    2016-06-10

    copyrighted material in the thesis manuscript entitled: Effects of 40ŕ’. Phosphoric Acid Etch on the Compressive Strength of Biodentine Is...Uniformed Services University Date: 04/0112016 26       Effects of 40% Phosphoric Acid Etch on the Compressive Strength of Biodentine ...whether an application of 40% phosphoric acid etch significantly alters the compressive strength of Biodentine , a relatively new calcium silicate

  7. STUDY ON THE EFFECTS OF ACID ETCHING ON AFFECTED ENAMEL

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    Simona Stoleriu

    2011-12-01

    Full Text Available The purpose of the study was to establish and compare the effects of ortophosphoric and hydrochloric acids on the enamel affected by incipient carious lesions with different evolution. Materials and method. 20 teeth with acute and chronic non-cavitary carious lesions were considered for the study. The teeth were sectioned in two halves through the middle of the non-cavitary lesions. The halves of 5 white spot-type lesions and of 5 brown spot-type ones were analyzed as to their surface roughness, on an atomic force microscope (AFM. 5 halves with white spot-type lesions and 5 halves with brown spot-type ones were subjected to acid etching with 37% ortophosphoric acid (Scotchbond etchant gel, 3M ESPE, and an equal number of samples was subjected to the action of 15% hydrochloric acid (ICON-etch, DMG Dental Products Ltd for 2 min, then washed with water and analyzed by AFM. Results. The initial surface roughness of the enamel was higher in the white spot–type carious lesions, comparatively with the brown spot-type ones. For both types of carious non-cavitary lesions, acid etching with phosphoric and hydrochloric acid significantly increased the surface roughness of the enamel, comparatively with the status of the enamel surface prior to etching. The hydrochloric acid led to a surface roughness significantly higher than in the case of ortophosphoric acid, in both acute and chronic non-cavitary carious lesions. The roughness values obtained through etching with ortophosphoric and hydrochloric acid were higher in the white spot-type carious lesions, comparatively with the brown spot-type ones. Conclusions. Both the 37% ortophosphoric acid and the 15% hydrochloric acid determined a significantly higher surface roughness of the enamel affected by acute and chronic non-cavitary carious lesions. The surface condition of the brown spot-type carious lesions was less significantly modified, comparatively with that of the white spot-type lesions, by the

  8. Acid etching and plasma sterilization fail to improve osseointegration of grit blasted titanium implants

    DEFF Research Database (Denmark)

    Mortensen, Mikkel Saksø; Jakobsen, Stig Storgaard; Saksø, Henrik

    2012-01-01

    compared with acid etched grit blasted implants. In the second study grit blasted implants were compared with acid etched grit blasted implants that were further treated with plasma sterilization. Implant performance was evaluated by histomorphometrical investigation (tissue-to-implant contact, peri......-implant tissue density) and mechanical push-out testing after four weeks observation time.Neither acid etching nor plasma sterilization of the grit blasted implants enhanced osseointegration or mechanical fixation in this press-fit canine implant model in a statistically significant manner....

  9. Nanostructural effect of acid-etching and fluoride application on human primary and permanent tooth enamels

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    Cheong, Youjin [Department of Biomedical Engineering and Healthcare Industry Research Institute, College of Medicine, Kyung Hee University, Seoul (Korea, Republic of); Choi, Samjin [Department of Biomedical Engineering and Healthcare Industry Research Institute, College of Medicine, Kyung Hee University, Seoul (Korea, Republic of); Department of Orthodontics, College of Dental Medicine, Kyung Hee University, Seoul (Korea, Republic of); Kim, So Jung [Department of Pediatric Dentistry, College of Dental Medicine, Kyung Hee University, Seoul (Korea, Republic of); Park, Hun-Kuk, E-mail: sigmoidus@khu.ac.kr [Department of Biomedical Engineering and Healthcare Industry Research Institute, College of Medicine, Kyung Hee University, Seoul (Korea, Republic of); Program of Medical Engineering, Kyung Hee University, Seoul (Korea, Republic of)

    2012-07-01

    This study examined the nanostructural effects of fluoride application and the acid-etching time with respect to the time elapsed after fluoride application on the primary and permanent tooth enamel layers using atomic force microscopy (AFM) and scanning electron microscopy (SEM). 192 non-carious teeth were assigned to sixteen experimental groups (n = 12) including primary (1 to 8) and permanent (9 to 16) teeth, based on the timing of acid-etching with 37% phosphoric acid after an acidulated phosphate fluoride (APF) pre-treatment. The APF pre-treatment led to a decrease in surface roughness in both the primary and permanent teeth. After the APF treatment, the roughness in both primary and permanent teeth increased with the time elapsed. An acid-etching time of 40 s led to increased nanostructural changes in the enamel surfaces compared to the conventional acid-etching time of 20 s. This acid-etching process led to a higher roughness changes in the primary teeth than in the permanent teeth. To obtain proper enamel adhesion of a sealant after APF pre-treatment, it is important to apply acid-etching two weeks after pre-treatment. In addition, the acid-etching time should be prolonged to apply etching more quickly than two weeks, regardless of the primary and permanent teeth. Highlights: Black-Right-Pointing-Pointer APF pre-treatment led to decreased surface roughness in the enamel. Black-Right-Pointing-Pointer After APF treatment, the more roughness increased with increasing time elapsed. Black-Right-Pointing-Pointer Acid-etching should be performed two weeks after fluoride application.

  10. [The effect of acid etching on bond strength of different self-adhesive resin cements to dentin].

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    Xuan, Gui-hong; Wang, Hai-hua

    2015-06-01

    To investigate the effect of acid etching on bond strength (μTBS) of self-adhesive resin cements (Unicem, G-Cem, Clearfil SA Cement, BisCem) to dentin. Thirty-two human third molars without caries were used for the study. One fourth of the crowns were cut off, perpendicular to the long axis of the tooth with (Isomet) a low-speed saw, in order to expose the dentin surfaces of the sectioned sides. The sectioned dentin surfaces of the experimental groups were etched for 15 s. Subsequently, resin blocks were bonded to the dentin surfaces, with one of the four cements (Unicem, G-Cem, Clearfil SA Cement, BisCem). After being stored in water for 24 hours, all specimens were perpendicularly sectioned through the dentin-resin interfaces, prepared into beams about 1 mm×1 mm×8 mm for μTBS tests with micro-tensile tester. The micro-morphologies of the cement-dentin interfaces were assessed using scanning electron microscope. The data was analyzed using SPSS16.0 software package. Without pre-treatment of acid etching, Unicem group (12.9±3.2) MPa, G-Cem group (11.7±2.6) MPa and Clearfil SA Cement group (10.9±2.3) MPa possessed a higher bond strength than BisCem group (6.8±2.4) MPa (Padhesive cements (G-Cem, Clearfil SA CementUnicem, Unicem), but there was no significant difference in bond strength in BisCem group with or without acid etching. With pretreatment of acid etching, the bond strength of self-adhesive resin cements to dentin decreases in G-Cem, Clearfil SA Cement and Unicem group, while there is no significant effect on the bond strength of BisCem group. Supported by Public Technology Applied Research Project of Science and Technology Bureau of Shaoxing City of Zhejiang Province (2012B70079).

  11. Influence of previous acid etching on bond strength of universal adhesives to enamel and dentin.

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    Torres, Carlos Rocha Gomes; Zanatta, Rayssa Ferreira; Silva, Tatiane Josefa; Huhtala, Maria Filomena Rocha Lima; Borges, Alessandra Bühler

    2017-01-01

    The objective of this study was to evaluate the effect of acid pretreatment on the bond strength of composite resin bonded to enamel and dentin with 2 different universal self-etching adhesives. The null hypothesis was that the acid treatment performed prior to adhesive application would not significantly change the bond strength to enamel or dentin for either universal adhesive tested. A sample of 112 bovine incisors were selected and embedded in acrylic resin. Half were ground until a flat enamel surface was obtained, and the other half were polished until a 6 × 6-mm area of dentin was exposed, resulting into 2 groups (n = 56). The enamel and dentin groups were divided into 2 subgroups according to the adhesive system applied: Futurabond U or Scotchbond Universal. Each of these subgroups was divided into 2 additional subgroups (n = 14); 1 subgroup received phosphoric acid pretreatment, and 1 subgroup did not. The bond strength was assessed with a microtensile test. Data from enamel and dentin specimens were analyzed separately using 1-way analysis of variance. The acid pretreatment did not significantly change the bond strength of the adhesives tested, either to enamel (P = 0.4161) or to dentin (P = 0.4857). The acid etching pretreatment did not affect the bond strength to dentin and enamel when the tested universal multipurpose adhesive systems were used.

  12. Influence of type of bur and acid etching on dentin hydraulic conductance.

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    Bersezio, Cristian; Martín, Javier; Xaus, Gloria; Vildósola, Patricio; Oliveira, Osmir B; Moncada, Gustavo; Fernández, Eduardo

    2013-01-01

    The aim of this study was to compare ex vivo filtration rate (hydraulic conductance) in human dentin discs mechanically treated with diamond and carbide burs of different grain size with or without acid etching. Method: 60 healthy third molars, recently extracted from patients aged 18-30 years, were cleaned, disinfected (0.1% thymol) and embedded in epoxy resin blocks. Dentin discs were obtained by cutting the occlusal surface with cylindrical rotary instruments, forming nine groups containing 12 specimens each: 1: fine grain (FG); 2: medium grain (MG); 3: coarse grain (CG); 4: carbide (C) burs; 5: FG with acid etching (AE); 6: MG with AE; 7: CG with AE; 8: C with AE; 9: only AE. Hydraulic conductance was determined in the experimental model under constant pressure of 200mm H2O. No difference in hydraulic conductance was observed among dentin discs treated with different types of burs (p = 0.5). Differences were found in the hydraulic conductance of etched and non-etched dentin discs (p type of mechanical bur treatment does not affect dentin hydraulic conductance. Acid etching significantly increases dentin hydraulic conductance.

  13. Evaluating EDTA as a substitute for phosphoric acid-etching of enamel and dentin.

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    Imbery, Terence A; Kennedy, Matthew; Janus, Charles; Moon, Peter C

    2012-01-01

    Matrix metalloproteinases (MMPs) are proteolytic enzymes released when dentin is acid-etched. The enzymes are capable of destroying unprotected collagen fibrils that are not encapsulated by the dentin adhesive. Chlorhexidine applied after etching inhibits the activation of released MMPs, whereas neutral ethylenediamine tetra-acetic acid (EDTA) prevents the release of MMPs. The purpose of this study was to determine if conditioning enamel and dentin with EDTA can be a substitute for treating acid-etching enamel and dentin with chlorhexidine. A column of composite resin was bonded to enamel and dentin after conditioning. Shear bond strengths were evaluated after 48 hours and after accelerated aging for three hours in 12% sodium hypochlorite. Shear bond strengths ranged from 15.6 MP a for accelerated aged EDTA enamel specimens to 26.8 MPa for dentin conditioned with EDTA and tested after 48 hours. A three-way ANOVA and a Tukey HSD test found statistically significant differences among the eight groups and the three independent variables (P dentin treated with chlorhexidine. Interactions of conditioning agent and aging were significant for dentin but not for enamel. In an effort to reduce the detrimental effects of MMPs, conditioning enamel and dentin with EDTA is an alternative to treating acid-etched dentin and enamel with chlorhexidine.

  14. PHOSPHATED, ACID-ETCHED IMPLANTS DECREASE MINERAL APPOSITION RATES NEAR IMPLANTS IN CANINES

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    Foley, Christine Hyon; Kerns, David G.; Hallmon, William W.; Rivera-Hidalgo, Francisco; Nelson, Carl J.; Spears, Robert; Dechow, Paul C.; Opperman, Lynne A.

    2010-01-01

    Purpose: This study evaluated the effects of phosphate-coated titanium on mineral apposition rate (MAR) and new bone-to-implant contact (BIC) in canines. Materials and Methods: 2.2 mm × 4 mm electrolytically phosphated or non-phosphated titanium implants with acid-etched surfaces were placed in 48 mandibular sites in 6 foxhounds. Tetracycline and calcein dyes were administered 1 week after implant placement and 1 week before sacrifice. At twelve weeks following implant healing, animals were sacrificed. MAR and BIC were evaluated using fluorescence microscopy. Light microscopic and histological evaluation was performed on undecalcified sections. Results: Microscopic evaluation showed the presence of healthy osteoblasts lining bone surfaces near implants. Similar bone-to-implant contact was observed in phosphated and non-phosphated titanium implant sites. MAR was significantly higher near non-phosphated titanium implant surfaces than the phosphated titanium samples. No significant differences were found between dogs or implant sites. Discussion and Conclusion: Acid-etched only implants showed significantly higher mineral apposition rates compared to acid-etched, phosphate-coated implants. PMID:20369085

  15. Effect of phosphoric acid etching on the shear bond strength of two self-etch adhesives

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    Camila SABATINI

    2013-01-01

    Full Text Available Objective To evaluate the effect of optional phosphoric acid etching on the shear bond strength (SBS of two self-etch adhesives to enamel and dentin. Material and Methods Ninety-six bovine mandibular incisors were ground flat to obtain enamel and dentin substrates. A two-step self-etch adhesive (FL-Bond II and a one-step self-etch adhesive (BeautiBond were applied with and without a preliminary acid etching to both the enamel and dentin. The specimens were equally and randomly assigned to 4 groups per substrate (n=12 as follows: FL-Bond II etched; FL-Bond II un-etched; BeautiBond etched; BeautiBond un-etched. Composite cylinders (Filtek Z100 were bonded onto the treated tooth structure. The shear bond strength was evaluated after 24 hours of storage (37°C, 100% humidity with a testing machine (Ultra-tester at a speed of 1 mm/min. The data was analyzed using a two-way ANOVA and post-hoc Tukey's test with a significance level of p<0.05. A field emission scanning electron microscope was used for the failure mode analysis. Results Both adhesives evidenced a significant decrease in the dentin SBS with the use of an optional phosphoric acid-etching step (p<0.05. Preliminary phosphoric acid etching yielded significantly higher enamel SBS for FL-Bond II (p<0.05 only, but not for BeautiBond. FL-Bond II applied to un-etched dentin demonstrated the highest mean bond strength (37.7±3.2 MPa and BeautiBond applied to etched dentin showed the lowest mean bond strength (18.3±6.7 MPa among all tested groups (p<0.05. Conclusion The use of a preliminary acid-etching step with 37.5% phosphoric acid had a significant adverse effect on the dentin bond strength of the self-etch adhesives evaluated while providing improvement on the enamel bond strength only for FL-Bond II. This suggests that the potential benefit that may be derived from an additional etching step with phosphoric acid does not justify the risk of adversely affecting the bond strength to dentin.

  16. Effect of phosphoric acid etching on the shear bond strength of two self-etch adhesives

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    SABATINI, Camila

    2013-01-01

    Objective: To evaluate the effect of optional phosphoric acid etching on the shear bond strength (SBS) of two self-etch adhesives to enamel and dentin. Material and Methods: Ninety-six bovine mandibular incisors were ground flat to obtain enamel and dentin substrates. A two-step self-etch adhesive (FL-Bond II) and a one-step self-etch adhesive (BeautiBond) were applied with and without a preliminary acid etching to both the enamel and dentin. The specimens were equally and randomly assigned to 4 groups per substrate (n=12) as follows: FL-Bond II etched; FL-Bond II un-etched; BeautiBond etched; BeautiBond un-etched. Composite cylinders (Filtek Z100) were bonded onto the treated tooth structure. The shear bond strength was evaluated after 24 hours of storage (37ºC, 100% humidity) with a testing machine (Ultra-tester) at a speed of 1 mm/min. The data was analyzed using a two-way ANOVA and post-hoc Tukey's test with a significance level of padhesives evidenced a significant decrease in the dentin SBS with the use of an optional phosphoric acid-etching step (pself-etch adhesives evaluated while providing improvement on the enamel bond strength only for FL-Bond II. This suggests that the potential benefit that may be derived from an additional etching step with phosphoric acid does not justify the risk of adversely affecting the bond strength to dentin. PMID:23559113

  17. Influence of particle abrasion or hydrofluoric acid etching on lithium disilicate flexural strength.

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    Menees, Timothy S; Lawson, Nathaniel C; Beck, Preston R; Burgess, John O

    2014-11-01

    Lithium disilicate is a translucent, glass-containing material used for ceramic restorations. Clinicians frequently use alumina abrading or hydrofluoric acid etching to create micromechanical retention in the intaglio surface before bonding a lithium disilicate restoration to the tooth. Few studies have investigated how the etching or abrasion processes affect the flexural strength of lithium disilicate ceramics. The purpose of this study was to measure and compare the flexural strength of e.max CAD after alumina abrasion at differing pressures and acid etching at differing concentrations and times. Bars of e.max CAD (9 groups of 10; 22×2.5×2.5 mm) were prepared, polished sequentially with 180, 320, and 600 abrasive paper, and sintered according to the manufacturer's instructions. Four groups were particle abraded (30-μm alumina particles from 10 mm at 55, 100, 200, or 300 kPa for 10 seconds). Four groups were etched with either 5% hydrofluoric acid (20 seconds or 120 seconds) or 9.5% hydrofluoric acid (20 seconds or 120 seconds). The control was polished and fired only (no treatment). Specimens were placed onto an Instron (1 mm/min crosshead speed) and loaded to failure in a 3-point flexural test. One-way ANOVA and the Dunnett t test determined intergroup differences (α=.05). Compared with the control, the 100, 200, and 300 kPa alumina abraded groups produced significantly lower flexural strengths (P.050); however, the 9.5% hydrofluoric acid at 20 seconds group was nearly statistically significant (P=.051). Alumina particle abrasion at pressures of 100 kPa and higher significantly reduced flexural strength by creating stress risers in e.max CAD and should not be used. Hydrofluoric acid etching should be used to increase micromechanical retention and clean the intaglio surface of the restoration before bonding. Copyright © 2014 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  18. The bonding of heavy metals on nitric acid-etched coal fly ashes functionalized with 2-mercaptoethanol or thioglycolic acid

    Energy Technology Data Exchange (ETDEWEB)

    Muñoz, M.I. [Department of Applied Chemistry and Physics, Area of Analytical Chemistry, Faculty of Biological and Environmental Sciences, Campus de Vegazana, s/n, University of León, E-24071 León (Spain); Aller, A.J., E-mail: aj.aller@unileon.es [Department of Applied Chemistry and Physics, Area of Analytical Chemistry, Faculty of Biological and Environmental Sciences, Campus de Vegazana, s/n, University of León, E-24071 León (Spain); Littlejohn, D. [WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL (United Kingdom)

    2014-02-14

    Coal fly ash is a waste by-product of the coal fire industry, which generates many environmental problems. Alternative uses of this material would provide efficient solutions for this by-product. In this work, nitric acid-etched coal fly ash labelled with 2-mercaptoethanol or thioglycolic acid was assessed for retention of Al(III), As(III), Cu(II), Cd(II), Fe(III), Mn(II), Hg(II), Ni(II), Pb(II) and Zn(II) ions. The bonding characteristics between the organic compounds with the solid support, as well as with the metal ions, were evaluated using various surface analytical techniques. Visualization of the organically-functionalized coal fly ash particle was possible using scanning electron microscopy (SEM), while the elemental composition of the functionalized material, before and after retention of the metal ions, was obtained by energy dispersive (ED)-X ray spectrometry (XRS) and electrothermal atomic absorption spectrometry (ETAAS). Fourier transform infrared (FT-IR) spectrometry and Raman spectrometry were used to obtain information about the functional groups. It was found that some metal(oid) ions (As, Ni, Pb, Zn) were coordinated through the mercaptan group, while other metal(oid)s (Al, Cd, Cu, Fe, Hg, Mn) were apparently bonded to oxygen atoms. A low-cost and effective solid phase retention system for extraction of heavy metals from aqueous solutions was thus developed. - Graphical abstract: Nitric acid-etched coal fly ash labelled with 2-mercaptoethanol or thioglycolic acid was intended for the retention of heavy metals. The bonding characteristics between the organic compounds with the solid support, as well as with the metal ions, were evaluated using surface analytical techniques. - Highlights: • Coal fly ashes were organically-functionalized. • Organically-functionalized coal fly ashes were spectrometrically characterized. • Organically-functionalized coal fly ashes can be used as an effective solid sorbent for metal(oid)s. • This retention

  19. Cell Adhesion and in Vivo Osseointegration of Sandblasted/Acid Etched/Anodized Dental Implants

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    Mu-Hyon Kim

    2015-05-01

    Full Text Available The authors describe a new type of titanium (Ti implant as a Modi-anodized (ANO Ti implant, the surface of which was treated by sandblasting, acid etching (SLA, and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigate its osseointegration characteristics in vivo. Four different types of Ti implants were examined, that is, machined Ti (control, SLA, anodized, and Modi-ANO Ti. In the cell adhesion study, Modi-ANO Ti showed higher initial MG-63 cell adhesion and induced greater filopodia growth than other groups. In vivo study in a beagle model revealed the bone-to-implant contact (BIC of Modi-ANO Ti (74.20% ± 10.89% was much greater than those of machined (33.58% ± 8.63%, SLA (58.47% ± 12.89, or ANO Ti (59.62% ± 18.30%. In conclusion, this study demonstrates that Modi-ANO Ti implants produced by sandblasting, acid etching, and anodizing improve cell adhesion and bone ongrowth as compared with machined, SLA, or ANO Ti implants. These findings suggest that the application of Modi-ANO surface treatment could improve the osseointegration of dental implant.

  20. In vitro evaluation of microleakage around orthodontic brackets using laser etching and Acid etching methods.

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    Mohammad Hossein Toodehzaeim

    2014-06-01

    Full Text Available path of microleakage between the enamel and adhesive potentially allows microbial ingress that may consequently cause enamel decalcification. The aim of this study was to compare microleakage of brackets bonded either by laser or acid etching techniques.The specimens were 33 extracted premolars that were divided into three groups as the acid etching group (group 1, laser etching with Er:YAG at 100 mJ and 15 Hz for 15s (group 2, and laser etching with Er:YAG at 140 mJ and 15 Hz for 15s (group 3. After photo polymerization, the teeth were subjected to 500 thermal cycles. Then the specimens were sealed with nail varnish, stained with 2% methylen blue for 24hs, sectioned, and examined under a stereomicroscope. They were scored for marginal microleakage that occurred between the adhesive-enamel and bracket-adhesive interfaces from the occlusal and gingival margins. Data were analyzed with the Kruskal- Wallis test.For the adhesive-enamel and bracket-adhesive surfaces, significant differences were not observed between the three groups.According to this study, the Er:YAG laser with 1.5 and 2.1 watt settings may be used as an adjunctive for preparing the surface for orthodontic bracket bonding.

  1. Rolled-Up Nanotech: Illumination-Controlled Hydrofluoric Acid Etching of AlAs Sacrificial Layers

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    Costescu Ruxandra

    2009-01-01

    Full Text Available Abstract The effect of illumination on the hydrofluoric acid etching of AlAs sacrificial layers with systematically varied thicknesses in order to release and roll up InGaAs/GaAs bilayers was studied. For thicknesses of AlAs below 10 nm, there were two etching regimes for the area under illumination: one at low illumination intensities, in which the etching and releasing proceeds as expected and one at higher intensities in which the etching and any releasing are completely suppressed. The “etch suppression” area is well defined by the illumination spot, a feature that can be used to create heterogeneously etched regions with a high degree of control, shown here on patterned samples. Together with the studied self-limitation effect, the technique offers a way to determine the position of rolled-up micro- and nanotubes independently from the predefined lithographic pattern.

  2. Microleakage of occlusoproximal adhesive restorations, effect of dentin moisture after acid etching.

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    Carpena Lopes, G; Colle Zanette, A

    2009-01-01

    The aim of this study was to evaluate the effect of dentin moisture after acid-etching on marginal sealing in occluso-proximal composite restorations. Ninety occluso-proximal preparations were made in posterior teeth with gingival margin in dentin. Prepared teeth were divided in 3 groups (N=30) according to the type of solvent of adhesive (ethanol/water=SB, Single Bond 3M ESPE, acetone=PB, Prime & Bond NT Dentsply, and ethanol=OP, OptiBond Solo Plus, Kerr). And 3 subgroups (N=10) according to the types of treatment of the cavity after rinsing the acid etchant ( 1) cavity air-dried for 10 s at a distance of 1 cm; 2) cavity blot-dried with slightly moist cotton pellets; 3) cavity with visible excess of water). Hybrid composite was applied in four increments. After 24 hours, teeth were thermocycled (500 cycles, 30 s, 5 to 55 masculineC) and immersed in 0.5% basic fucsin for 4 hours. The teeth were cleaned, dried and sectioned. The microleakage extent was analyzed with a 0-5 scale in dentin margin. Enamel margins were verified for presence or absence of microleakage. Data were submitted to Kruskal Wallis test (Pdentin margins were: SB_a=1, SB_b=0, SB_c=1, PB_a=1, PB_b=1, PB_c=2, OP_a=0, OP_b=1, OP_c=1. Considering bonding systems, PB provided more microleakage than SB and OP (P=0.0316). In groups where cavity had visible excess of water there was higher microleakage degree than the dry cavity subgroups (P=0.048). In enamel margins, median was 0 for all groups. Better marginal sealing is obtained in dentin margins of occluso-proximal cavities when they are air-dried or blot-dried with cotton pellets after acid-etching.

  3. Acid resistance of erbium-doped yttrium aluminum garnet laser-treated and phosphoric acid-etched enamels.

    Science.gov (United States)

    Kim, Jung-Ho; Kwon, Oh-Won; Kim, Hyung-Il; Kwon, Yong Hoon

    2006-11-01

    To compare the effects of erbium-doped yttrium aluminum garnet (Er:YAG) laser ablation and of phosphoric acid etching on the in vitro acid resistance of bovine enamel. Teeth were polished to make the surface flat. The polished enamel was either etched with 37% phosphoric acid for 30 seconds or ablated with a single 33 J/cm2 pulse from an Er:YAG laser. The control specimens were free from acid etching and laser ablation. Changes in crystal structure, dissolved mineral (calcium [Ca] and phosphorus [P]) contents, and calcium distribution in the enamel subsurface after a pH-cycling process were evaluated. After laser treatment, poor crystal structures improved without forming any new phases, such as tricalcium phosphates. Among the tested enamels, dissolved mineral contents were significantly different (P phosphoric acid-etched enamels had the highest (Ca, 15.90 ppm; P, 7.33 ppm). The reduction rate and reduced depth of calcium content along the subsurface were lowest in Er:YAG laser-treated enamels. The Er:YAG laser-treated enamels are more acid resistant to acid attack than phosphoric acid-etched enamels.

  4. The impact of hydrofluoric acid etching followed by unfilled resin on the biaxial strength of a glass-ceramic.

    Science.gov (United States)

    Posritong, Sumana; Borges, Alexandre Luiz Souto; Chu, Tien-Min Gabriel; Eckert, George J; Bottino, Marco A; Bottino, Marco C

    2013-11-01

    To evaluate the null hypotheses that hydrofluoric (HF) acid etching time would neither decrease the biaxial flexural strength of a glass-based veneering ceramic nor enhance it after silane and unfilled resin (UR) applications. Disc-shaped IPS e.max ZirPress specimens were allocated into 12 groups: G1-control (no-etching), G2-30 s, G3-60 s, G4-90 s, G5-120 s, G6-60 s+60 s. Groups (G7-G12) were treated in the same fashion as G1-G6, but followed by silane and UR applications. Surface morphology and roughness (Ra and Rq) of the ceramics were assessed by means of scanning electron microscopy (SEM) and profilometry, respectively. Flexural strength was determined by biaxial testing. Data were analyzed by two-way ANOVA and the Sidak test (α=0.05). Weibull statistics were estimated and finite element analysis (FEA) was carried out to verify the stress concentration end areas of fracture. The interaction (etching time vs. surface treatment) was significant for Ra (p=0.008) and Rq (0.0075). Resin-treated groups presented significantly lower Ra and Rq than non-treated groups, except for the 60s group (pceramic microstructure and that the UR was able to penetrate into the irregularities. A significant effect of etching time (p=0.029) on flexural strength was seen. G7-G12 presented higher strength than G1-G6 (pceramic flexural strength. Moreover, the flexural strength could be enhanced after UR treatment. Copyright © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  5. Radiographic and clinical outcomes of rooted, platform-switched, microthreaded implants with a sandblasted, large-grid, and acid-etched surface: A 5-year prospective study.

    Science.gov (United States)

    Mei, Dong Mei; Zhao, Baodong; Xu, Hao; Wang, Yanhui

    2017-10-20

    There is no data available on the long-term outcomes of a rooted, platform-switched, microthreaded implant with a sandblasted, large-grid, and acid-etched surface. This prospective, longitudinal study evaluated the clinical and radiographic outcomes of rooted, platform-switched, microthreaded and sandblasted, large-grid, and acid-etched (SLA) surface implants for 5 years. Sixty implants were placed in sixty patients with partially edentulous maxillae or mandibles. The permanent prostheses were inserted 2-4 months after implant placement. Clinical and radiographic examinations were performed at follow-up visits scheduled postoperation, prosthesis installation, 1 year, and 5 years after surgery, to assess implant survival and success rates, biological and mechanical complications, and marginal bone loss. After 5 years' follow-up, four patients withdrawn from the study, and 56 implants achieved a 100% survival rate and 98.2% success rate. Three prosthetic complications occurred, resulting in a success rate for prostheses of 94.6%. The incidence of peri-implant mucositis was 9.1% and no peri-implantitis was diagnosed. The average marginal bone loss at the mesial aspect was 0.46 ± 0.27 mm after 1 year and 0.48 ± 0.27 mm after 5 years. The average marginal bone loss at the distal aspect was 0.46 ± 0.32 mm after 1 year and 0.50 ± 0.35 mm after 5 years. After 5 years of loading, the rooted, platform-switched, microthreaded, and SLA surface implants showed high survival and success rates, steady crestal bone levels, and excellent long-term clinical outcomes in the soft tissue. Overloading may be related to the marginal bone loss around implants, but the surgical protocol, different sites, and jaw position did not correlate with crestal bone loss. © 2017 Wiley Periodicals, Inc.

  6. Hydrogen content in titanium and a titanium–zirconium alloy after acid etching

    Energy Technology Data Exchange (ETDEWEB)

    Frank, Matthias J.; Walter, Martin S. [Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, P.O. Box 1109, Blindern, NO-0317 Oslo (Norway); Institute of Medical and Polymer Engineering, Chair of Medical Engineering, Technische Universität München, Boltzmannstrasse 15, 85748 Garching (Germany); Lyngstadaas, S. Petter [Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, P.O. Box 1109, Blindern, NO-0317 Oslo (Norway); Wintermantel, Erich [Institute of Medical and Polymer Engineering, Chair of Medical Engineering, Technische Universität München, Boltzmannstrasse 15, 85748 Garching (Germany); Haugen, Håvard J., E-mail: h.j.haugen@odont.uio.no [Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, P.O. Box 1109, Blindern, NO-0317 Oslo (Norway)

    2013-04-01

    Dental implant alloys made from titanium and zirconium are known for their high mechanical strength, fracture toughness and corrosion resistance in comparison with commercially pure titanium. The aim of the study was to investigate possible differences in the surface chemistry and/or surface topography of titanium and titanium–zirconium surfaces after sand blasting and acid etching. The two surfaces were compared by X-ray photoelectron spectroscopy, secondary ion mass spectroscopy, scanning electron microscopy and profilometry. The 1.9 times greater surface hydrogen concentration of titanium zirconium compared to titanium was found to be the major difference between the two materials. Zirconium appeared to enhance hydride formation on titanium alloys when etched in acid. Surface topography revealed significant differences on the micro and nanoscale. Surface roughness was increased significantly (p < 0.01) on the titanium–zirconium alloy. High-resolution images showed nanostructures only present on titanium zirconium. - Highlights: ► TiZr alloy showed increased hydrogen levels over Ti. ► The alloying element Zr appeared to catalyze hydrogen absorption in Ti. ► Surface roughness was significantly increased for the TiZr alloy over Ti. ► TiZr alloy revealed nanostructures not observed for Ti.

  7. Effect of Hydrofluoric Acid Etching Time on Titanium Topography, Chemistry, Wettability, and Cell Adhesion.

    Directory of Open Access Journals (Sweden)

    R Zahran

    Full Text Available Titanium implant surface etching has proven an effective method to enhance cell attachment. Despite the frequent use of hydrofluoric (HF acid, many questions remain unresolved, including the optimal etching time and its effect on surface and biological properties. The objective of this study was to investigate the effect of HF acid etching time on Ti topography, surface chemistry, wettability, and cell adhesion. These data are useful to design improved acid treatment and obtain an improved cell response. The surface topography, chemistry, dynamic wetting, and cell adhesiveness of polished Ti surfaces were evaluated after treatment with HF acid solution for 0, 2; 3, 5, 7, or 10 min, revealing a time-dependent effect of HF acid on their topography, chemistry, and wetting. Roughness and wetting increased with longer etching time except at 10 min, when roughness increased but wetness decreased. Skewness became negative after etching and kurtosis tended to 3 with longer etching time. Highest cell adhesion was achieved after 5-7 min of etching time. Wetting and cell adhesion were reduced on the highly rough surfaces obtained after 10-min etching time.

  8. Can previous acid etching increase the bond strength of a self-etching primer adhesive to enamel?

    Directory of Open Access Journals (Sweden)

    Ana Paula Morales Cobra Carvalho

    2009-06-01

    Full Text Available Because a greater research effort has been directed to analyzing the adhesive effectiveness of self etch primers to dentin, the aim of this study was to evaluate, by microtensile testing, the bond strength to enamel of a composite resin combined with a conventional adhesive system or with a self-etching primer adhesive, used according to its original prescription or used with previous acid etching. Thirty bovine teeth were divided into 3 groups with 10 teeth each (n= 10. In one of the groups, a self-etching primer (Clearfil SE Bond - Kuraray was applied in accordance with the manufacturer's instructions and, in the other, it was applied after previous acid etching. In the third group, a conventional adhesive system (Scotchbond Multipurpose Plus - 3M-ESPE was applied in accordance with the manufacturer's instructions. The results obtained by analysis of variance revealed significant differences between the adhesive systems (F = 22.31. The self-etching primer (Clearfil SE Bond presented lower enamel bond strength values than the conventional adhesive system (Scotchbond Multipurpose Plus (m = 39.70 ± 7.07 MPa both when used according to the original prescription (m = 27.81 ± 2.64 MPa and with previous acid etching (m = 25.08 ± 4.92 MPa.

  9. Investigation of acid-etched CO2 laser ablated enamel surfaces using polarization sensitive optical coherence tomography

    Science.gov (United States)

    Nahm, Byung J.; Kang, Hobin; Chan, Kenneth; Fried, Daniel

    2012-01-01

    A carbon dioxide laser operating at the highly absorbed wavelength of 9.3μm with a pulse duration of 10-15μs is ideally suited for caries removal and caries prevention. The enamel thermally modified by the laser has enhanced resistance to acid dissolution. This is an obvious advantage for caries prevention; however, it is often necessary to etch the enamel surface to increase adhesion to composite restorative materials and such surfaces may be more resistant to etching. The purpose of the study was to non-destructively measure the susceptibility of laser-ablated enamel surfaces to acid dissolution before and after acid-etching using Polarization Sensitive Optical Coherence Tomography (PS-OCT). PS-OCT was used to acquire images of bovine enamel surfaces after exposure to laser irradiation at ablative fluence, acid-etching, and a surface softened dissolution model. The integrated reflectivity from lesion and the lesion depth were measured using PS-OCT. Samples were also sectioned for examination by Polarized Light Microscopy (PLM). PS-OCT images showed that acid-etching greatly accelerated the formation of subsurface lesions on both laser-irradiated and non-irradiated surfaces (Plaser modified enamel layer after 5-10 seconds.

  10. Effect of the time-point of acid etching on the persistence of sealer residues after using different dental cleaning protocols

    Directory of Open Access Journals (Sweden)

    Keren Cristina Fagundes JORDÃO-BASSO

    Full Text Available Abstract: Endodontic sealer residues remaining within the pulp chamber dentin after root canal obturation and cleaning with various solvents may compromise the appearance and the durability of dental restorations. Acid etching is routinely performed prior to application of dentine adhesive systems, but is effect on residual sealer material and the optimal time-point for performing etching, are unknown. Here, we evaluated the effect of acid etching on the dentin surface when performed either immediately or 7 days after removal of the endodontic sealer with two solvents, i.e., 95% ethanol or xylol. Forty crowns fragments from bovine incisors were impregnated with sealer and divided into 4 groups (n = 10 each, according to the dentin cleaning protocol and to the acid etching time-point: G1, 95.0% ethanol and immediate acid etching; G2, xylol and immediate acid etching; G3, 95.0% ethanol and acid etching after 7 days; and G4, xylol and acid etching after 7 days. Scanning electron microscopy (SEM images (2000 × were obtained from each specimen and the number of open dentinal tubules counted and compared. Another 40 fragments were similarly prepared, and SEM images were obtained (500 × to score and compare the persistence of sealer residues on the dentin. G4 showed the most open dentinal tubules and the least epoxy resin-based sealer residues on the dentin surface (p < 0.05. The least epoxy resin-based sealer residues was obtained when acid etching, using 37% phosphoric acid, was performed after 7 days after cleaning the dentin with xylol.

  11. Effects of Additional Acid Etching on the Dentin Bond Strengths of One-Step Self-Etch Adhesives Applied to Primary Teeth.

    Science.gov (United States)

    Kim, Yuhyun; Kim, Shin; Jeong, Taesung; Son, Sung-Ae; Kim, Jiyeon

    2017-04-01

    The aim of this study was to evaluate the bond strengths of one-step self-etch adhesives applied to primary tooth dentin with and without additional acid etching. In total, 154 specimens were prepared using 50 naturally exfoliated primary molars. Four commercial one-step self-etch adhesives were used in this study: Scotchbond™ Universal, All-Bond Universal™, Adper™ Prompt™ L-Pop™, and Clearfil S3 Bond™. Two etch-and-rinse adhesives, Prime & Bond® NT™ and Scotchbond™ Multi-Purpose, served as controls. Microtensile bond strength tests were performed for specimens treated with the one-step self-etch adhesives with and without additional acid etching and those treated with the two etch-and-rinse adhesives. All one-step self-etch adhesives except Adper Prompt L-Pop exhibited increased microtensile bond strength values (p etching. A nonsignificant interaction was observed between the type of self-etch adhesive and additional acid etching (p = 0.056). Bond strength comparisons between the self-etch adhesives used without additional acid etching and the etch-and-rinse adhesives revealed significantly higher values for Prime & Bond NT than for All-Bond Universal® (p etch-and-rinse adhesive and self-etch adhesive used with additional acid etching, although Clearfil S3 Bond showed greater strength than Adper Prompt L-Pop. Our results suggest that additional acid etching increases the bond strength of most one-step self-etch adhesives applied to primary tooth dentin. Additional acid etching of enamel and dentin can be recommended to increase the bond strength of one-step self-etch adhesives applied to primary teeth. (J Esthet Restor Dent 29:110-117, 2017). © 2016 Wiley Periodicals, Inc.

  12. Characterization of Dentine to Assess Bond Strength of Dental Composites

    Science.gov (United States)

    Liaqat, Saad; Aljabo, Anas; Khan, Muhammad Adnan; Ben Nuba, Hesham; Bozec, Laurent; Ashley, Paul; Young, Anne

    2015-01-01

    This study was performed to develop alternating dentine adhesion models that could help in the evaluation of a self-bonding dental composite. For this purpose dentine from human and ivory was characterized chemically and microscopically before and after acid etching using Raman and SEM. Mechanical properties of dentine were determined using 3 point bend test. Composite bonding to dentine, with and without use of acid pre-treatment and/or the adhesive, were assessed using a shear bond test. Furthermore, micro gap formation after restoration of 3 mm diameter cavities in dentine was assessed by SEM. Initial hydroxyapatite level in ivory was half that in human dentine. Surface hydroxyapatites decreased by approximately half with every 23 s of acid etch. The human dentine strength (56 MPa) was approximately double that of ivory, while the modulus was almost comparable to that of ivory. With adhesive use, average shear bond strengths were 30 and 26 MPa with and without acid etching. With no adhesive, average bond strength was 6 MPa for conventional composites. This, however, increased to 14 MPa with a commercial flowable “self–bonding” composite or upon addition of low levels of an acidic monomer to the experimental composite. The acidic monomer additionally reduced micro-gap formation with the experimental composite. Improved bonding and mechanical properties should reduce composite failures due to recurrent caries or fracture respectively.

  13. Characterization of Dentine to Assess Bond Strength of Dental Composites

    Directory of Open Access Journals (Sweden)

    Saad Liaqat

    2015-04-01

    Full Text Available This study was performed to develop alternating dentine adhesion models that could help in the evaluation of a self-bonding dental composite. For this purpose dentine from human and ivory was characterized chemically and microscopically before and after acid etching using Raman and SEM. Mechanical properties of dentine were determined using 3 point bend test. Composite bonding to dentine, with and without use of acid pre-treatment and/or the adhesive, were assessed using a shear bond test. Furthermore, micro gap formation after restoration of 3 mm diameter cavities in dentine was assessed by SEM. Initial hydroxyapatite level in ivory was half that in human dentine. Surface hydroxyapatites decreased by approximately half with every 23 s of acid etch. The human dentine strength (56 MPa was approximately double that of ivory, while the modulus was almost comparable to that of ivory. With adhesive use, average shear bond strengths were 30 and 26 MPa with and without acid etching. With no adhesive, average bond strength was 6 MPa for conventional composites. This, however, increased to 14 MPa with a commercial flowable “self–bonding” composite or upon addition of low levels of an acidic monomer to the experimental composite. The acidic monomer additionally reduced micro-gap formation with the experimental composite. Improved bonding and mechanical properties should reduce composite failures due to recurrent caries or fracture respectively.

  14. Histological structures and acidic etching sensitivities of the enamels at the occlusal pit parts in the deciduous and permanent teeth

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Masashi [Department of Dental Hygiene, Nippon Dental University College at Niigata, Niigata 951-8580 (Japan)]. E-mail: masashi@ngt.ndu.ac.jp; Zheng, Jinhua [Department of Oral Anatomy, School of Dentistry at Niigata, Nippon Dental University, Niigata 951-8580 (Japan); Mori, Kazuhisa [Department of Oral Surgery, School of Dentistry at Niigata, Nippon Dental University, Niigata 951-8580 (Japan); Mataga, Izumi [Department of Oral Surgery, School of Dentistry at Niigata, Nippon Dental University, Niigata 951-8580 (Japan); Kobayashi, Kan [Department of Oral Anatomy, School of Dentistry at Niigata, Nippon Dental University, Niigata 951-8580 (Japan)

    2006-05-15

    The purpose of this study is to compare the histological structures and acidic etching sensitivities of the enamels at the occlusal pit parts between the deciduous molars and permanent molars. They were observed by the polarizing and scanning electron microscopies. The enamel rods were less made slender by EDTA etching and the outlines of the apatite crystals, constituting the enamel rods, were clearer at the occlusal pit part of the deciduous molar than that of the permanent molar in reverse of that at the cusp part. It is thought that the enamel at the occlusal pit part of the permanent molar is more easily decayed by the dental caries than that of the deciduous molar because the former is more easily decayed by the acidic etching than the latter in reverse at the cusp part. It is considered that the thin superficialmost layer of the enamel at the occlusal pit part of the permanent molar has originally higher degree of resistance to the dental caries.

  15. Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study

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    Nam-Ho Kim

    2015-01-01

    Full Text Available This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design. Methods. For experimental groups, SLA implants were coated with different concentrations of rhBMP-2 (0.1, 0.5, and 1 mg/mL. After assessment of surface characteristics and rhBMP-2 releasing profile, the experimental groups and untreated control groups (n = 6 in each group, two animals in each group were placed in split-mouth designed animal models with buccal open defect. At 8 weeks after implant placement, implant stability quotients (ISQ values were recorded and vertical bone height (VBH, mm, bone-to-implant contact ratio (BIC, %, and bone volume (BV, % in the upper 3 mm defect areas were measured. Results. The ISQ values were highest in the 1.0 group. Mean values of VBH (mm, BIC (%, and BV (% were greater in the 0.5 mg/mL and 1.0 mg/mL groups than those in 0.1 and control groups in buccal defect areas. Conclusion. In the open defect area surrounding the SLA implant, coating with 0.5 and 1.0 mg/mL concentrations of rhBMP-2 was more effective, compared with untreated group, in promoting bone regeneration and osseointegration.

  16. Hard machining, glaze firing and hydrofluoric acid etching: Do these procedures affect the flexural strength of a leucite glass-ceramic?

    Science.gov (United States)

    Fraga, Sara; Valandro, Luiz F; Bottino, Marco A; May, Liliana G

    2015-07-01

    To evaluate the effects of hard machining, glaze firing and hydrofluoric acid etching on the biaxial flexural strength and roughness of a CAD/CAM leucite glass-ceramic; to investigate if ceramic post-machining surface roughness is influenced by the machining order and by the pair of burs used for it. A hundred forty four discs were machined by six nominally identical pairs of burs and divided into groups (n=24): (1) machining-M, (2) machining and glaze firing-MG, (3) machining and hydrofluoric acid etching-MA, (4) machining, glaze firing and hydrofluoric acid etching-MGA, (5) machining followed by polishing, as a control-MP, (6) machining, polishing and hydrofluoric acid etching-MPA. The roughness after each treatment (Ra and Rz) was measured. The discs were submitted to a piston-on-three ball flexure test (ISO 6872/2008) and strength data analyzed through Weibull statistics (95% CI). M resulted in lower characteristic strength (σ0) (128.2MPa) than MP (177.2MPa). The glaze firing reduced σ0 (109MPa), without affecting roughness. Hydrofluoric acid etching increased the roughness without affecting σ0. Spearman's coefficient (rs) indicated strong and significant correlation between machining order and roughness (rsRa=-0.66; rsRz=-0.73). The ceramic post-machining surface roughness differed significantly according to the pair of burs employed (pmachining and glaze firing reduced the leucite ceramic strength, while hydrofluoric acid etching did not affect the strength. Variability in the roughness might be expected after machining, since it was influenced by the machining order and by the bur pairing. Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  17. Crystal growth vs. conventional acid etching: A comparative evaluation of etch patterns, penetration depths, and bond strengths

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    Devanna Raghu

    2008-01-01

    Full Text Available The present study was undertaken to investigate the effect on enamel surface, penetration depth, and bond strength produced by 37% phosphoric acid and 20% sulfated polyacrylic acid as etching agents for direct bonding. Eighty teeth were used to study the efficacy of the etching agents on the enamel surface, penetration depth, and tensile bond strength. It was determined from the present study that a 30 sec application of 20% sulfated polyacrylic acid produced comparable etching topography with that of 37% phosphoric acid applied for 30 sec. The 37% phosphoric acid dissolves enamel to a greater extent than does the 20% sulfated polyacrylic acid. Instron Universal testing machine was used to evaluate the bond strengths of the two etching agents. Twenty percent sulfated polyacrylic acid provided adequate tensile bond strength. It was ascertained that crystal growth can be an alternative to conventional phosphoric acid etching as it dissolves lesser enamel and provides adequate tensile bond strength.

  18. Effects of attrition, prior acid-etching, and cyclic loading on the bond strength of a self-etching adhesive system to dentin.

    Science.gov (United States)

    Shinkai, Koichi; Ebihara, Takashi; Shirono, Manabu; Seki, Hideaki; Wakaki, Suguru; Suzuki, Masaya; Suzuki, Shiro; Katoh, Yoshiroh

    2009-03-01

    The purpose of this study was to evaluate the effects of dentin attrition, phosphoric acid etching, and cyclic loading on the microtensile bond strength (microTBS) of a self-etching adhesive system to dentin. Flat dentin surfaces of human molars were assigned to eight experimental groups based on those with or without attrition, prior acid-etching, and cyclic loading. Resin composite paste was placed and polymerized after the bonding procedure according to manufacturer's instructions. The specimens were subjected to microTBS testing at a crosshead speed of 0.5 mm/min. Results showed that the minimum mean value of microTBS was 14.9 MPa in the group without attrition and acid-etching but with loading, while the maximum mean value of microTBS was 40.0 MPa in the group without attrition and loading but with acid etching. Therefore, the value of microTBS to dentin without attrition was significantly decreased by cyclic loading but that to dentin with attrition was not affected.

  19. Resonance frequency analysis of thermal acid-etched, hydrophilic implants during first 3 months of healing and osseointegration in an early-loading protocol

    NARCIS (Netherlands)

    van Eekeren, P.; Said, C.; Tahmaseb, A.; Wismeijer, D.

    2015-01-01

    Purpose: Safe loading of dental implants requires an optimal osseointegration. This osseointegration process during healing could be analyzed by resonance frequency analysis (RFA). The purpose of the study was to evaluate RFA changes during healing in splinted, early-loaded, thermal acid-etched,

  20. Effect of acid etching on marginal adaptation of mineral trioxide aggregate to apical dentin: microcomputed tomography and scanning electron microscopy analysis

    Science.gov (United States)

    Al-Fouzan, Khalid; Al-Garawi, Ziad; Al-Hezaimi, Khalid; Javed, Fawad; Al-Shalan, Thakib; Rotstein, Ilan

    2012-01-01

    The present investigation assessed the effect of acid etching on marginal adaptation of white- and gray-colored mineral trioxide aggregate (MTA) to apical dentin using microcomputed tomography (micro-CT) and scanning electron microscopy (SEM). Sixty-four extracted single-rooted human maxillary teeth were used. Following root-end resection and apical preparation, the teeth were equally divided into four groups according to the following root end filling materials: (i) white-colored MTA (WMTA), (ii) etched WMTA (EWMTA), (iii) gray-colored MTA (GMTA) and (iv) etched GMTA (EGMTA). After 48 h, the interface between root-end filling materials and the dentinal walls was assessed using micro-CT and SEM. Data were statistically analyzed using the Kruskal–Wallis and Dunn tests. Micro-CT analysis revealed gap volumes between the apical cavity dentin walls and EGMTA, GMTA, EWMTA and WMTA of (0.007 1±0.004) mm3, (0.053±0.002) mm3, (0.003 6±0.001) mm3 and (0.005 9±0.002) mm3 respectively. SEM analysis revealed gap sizes for EGMTA, WMTA, EWMTA and GMTA to be (492.3±13.8) µm, (594.5±17.12) µm, (543.1±15.33) µm and (910.7±26.2) µm respectively. A significant difference in gap size between root end preparations filled with GMTA and EGMTA was found (P<0.05). No significance difference in gap size between WMTA and EWMTA were found in either SEM or micro-CT analysis. In conclusion, pre-etching of apical dentin can provide a better seal for GMTA but not for WMTA. PMID:23306857

  1. Fiber tractography assessment in double cortex syndrome.

    Science.gov (United States)

    Iannetti, Paola; Nicita, Francesco; Spalice, Alberto; Parisi, Pasquale; Papetti, Laura; Verrotti, Alberto

    2011-08-01

    Subcortical band heterotopia (SBH) or double cortex syndrome is a malformation of cortical development that may be related to intractable epilepsy and severe mental retardation or to mild epilepsy and slight mental delay or normal cognitive functions. Several studies have been performed using neuroradiological or neurophysiological techniques, like SPECT, PET, MRS, fMRI, and MEG, in attempt to better characterize this neuronal migration disorder. Recently, also diffusion tensor imaging (DTI) and fiber tracking (FT) have been used to investigate on white matter anomalies in SBH, adding more information about such gray matter anomaly. We report on three cases of SBH, evaluated with MRI, DTI, and FT. The data gathered from DTI and TF allow us to hypothesize a new functional role for heterotopic gray matter.

  2. Comparative evaluation of shear bond strength of composite resin bonded to acid etched or Nd:Yag lased enamel

    Directory of Open Access Journals (Sweden)

    Mridula Goswami

    2011-01-01

    Full Text Available Aims: In vitro evaluation of the shear bond strength of composite resin bonded to enamel which is pretreated using acid etchant or pulsed Nd:YAG. Qualitative morphological changes in enamel surfaces were observed under a scanning electron microscope (SEM. Materials and Methods: 60 extracted human teeth were divided in two groups of 30 each (Groups A and B. In Group A, prepared surface of enamel was etched using 35% phosphoric acid (Scotchbond, 3M. In Group B, enamel was surface treated by a surgical Nd:YAG laser beam (Medilas 4060 Fibertom at 0.8 W, 10 Hz, for 10 s with 80 mJ/pulse power. Bonding agent (single bond dental adhesive, 3M was applied over the test areas on 20 samples of Groups A and B each, and light cured. Composite resin (Z 100, 3M was applied onto the test areas as a 3 mm diameter cylinder, and light cured. The samples were tested for shear bond strength. Remaining 10 samples from each group were observed under SEM for morphological changes. Results: The mean shear bond strength was 20.00 MPa (΁ 1.93 and 13.28 MPa (΁1.97 for Group A and B, respectively. The difference in mean values was statistically significant between Groups A and B (P<0.001. Under SEM, Group A showed typical honeycomb appearance and Group B showed bubble-like cavities. Conclusions: In enamel, acid etch technique showed higher shear bond strength.

  3. Shear bond strength between porcelain and nano filler composite resin with or without 9% hydrofluoric acid etching

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    Kun Ismiyatin

    2009-06-01

    Full Text Available Background: Reparation technique on restorations with broken or damaged porcelain which are still attached with the teeth are difficult, because it is very hard to remove the porcelain restoration without damaging it, and it needs a long time. Various ways have been developed to repair the broken porcelain, one of them is the use of composite resin as the material for the restoration of fractured porcelain. Repairing porcelain inside the mouth without removing the restoration of the damaged porcelain using light cured composite resins material seems to be an advantageous option because it is relatively simple, has low risks, good esthetically and cheap. Purpose: The objective of this study was to find out the difference of shear bond strength in porcelain reparation using nano filler composite resin with or without 9% hydrofluoric acid etching by using Autograph measuring device. Methods: Twenty pieces of the porcelain samples devided into 2 groups. Group I: etching process using 9% hydrofluoric acid, and group II : without etching process. Result: The data was analyzed using t test in a p value of 0.0001 (p≤0.05, which means there is a significant different of shear bond strength between treated group I and II. The biggest shear bond strength was in treatment group I. Conclusion: The use of 9% hydrofluoric acid on the surface of porcelain can increase the shear bond strength between porcelain and nano filler composite resin.

  4. The Effect of Hydrofluoric Acid Etching Duration on the Surface Micromorphology, Roughness, and Wettability of Dental Ceramics

    Directory of Open Access Journals (Sweden)

    Ravikumar Ramakrishnaiah

    2016-05-01

    Full Text Available The current laboratory study is evaluating the effect of hydrofluoric acid etching duration on the surface characteristics of five silica-based glass ceramics. Changes in the pore pattern, crystal structure, roughness, and wettability were compared and evaluated. Seventy-five rectangularly shaped specimens were cut from each material (IPS e-max™, Dentsply Celtra™, Vita Suprinity™, Vita mark II™, and Vita Suprinity FC™; the sectioned samples were finished, polished, and ultrasonically cleaned. Specimens were randomly assigned into study groups: control (no etching and four experimental groups (20, 40, 80 and 160 s of etching. The etched surfaces’ microstructure including crystal structure, pore pattern, pore depth, and pore width was studied under a scanning electron microscope, and the surface roughness and wettability were analyzed using a non-contact surface profilometer and a contact angle measuring device, respectively. The results were statistically analyzed using one-way analysis of variance (ANOVA and the post hoc Tukey’s test. The results showed a significant change in the pore number, pore pattern, crystal structure, surface roughness, and wettability with increased etching duration. Etching for a short time resulted in small pores, and etching for longer times resulted in wider, irregular grooves. A significant increase in the surface roughness and wettability was observed with an increase in the etching duration. The findings also suggested a strong association between the surface roughness and wettability.

  5. Comparative Study of the Early Loading of Resorbable Blasting Media and Sandblasting with Large-grit and Acid-etching Surface Implants: A Retrospective Cohort Study

    OpenAIRE

    Kim, Sung-Beom; Kim, Young-Kyun; Kim, Su-Gwan; Oh, Ji-Su; Kim, Byung-Hoon

    2014-01-01

    Purpose: This study compares the prognosis (the survival rate and marginal bone loss) of resorbable blasting media (RBM) surface implants and sandblasting with large-grit and acid-etching (SLA) surface implants in the early loading. Methods: This study targeted 123 patients treated by implants installation from January 2008 to March 2010. The loading was initiated in the maxilla within three to four months and in the mandible within one to two months. The types of restoration were single crow...

  6. Effect of different monomer-based composites and acid etching pre-treatment of enamel on the microleakage using self-etch adhesives systems.

    Science.gov (United States)

    Catelan, Anderson; Giorgi, Maria Cecília Caldas; Soares, Giulliana Panfiglio; Lima, Debora Alves Nunes Leite; Marchi, Giselle Maria; Aguiar, Flávio Henrique Baggio

    2014-11-01

    To evaluate quantitatively the marginal microleakage of restorations carried out with self-etching adhesives with or without prior phosphoric enamel acid etching of silorane or methacrylate resin-based composite restorations subjected to thermal cycling. Forty cavities were prepared at the proximal surface of bovine incisors and randomly divided according to the etching of the enamel and restorative system used. The groups were restored with methacrylate [Adper SE Plus adhesive (3M ESPE) + Filtek Z250 (3M ESPE)] or silorane [Filtek LS adhesive (3M ESPE) + Filtek LS composite (3M ESPE)] restorative systems, light-cured using a LED unit (Bluephase 16i, Vivadent). After restorative procedure and thermocycling (1000 cycles), the specimens were immersed in methylene blue for 2 h. The specimens were triturated and the powder was used for analysis in an absorbance spectrophotometer. Data were statistically analyzed by 2-way ANOVA (alpha = 0.05). No statistical difference between the restorative materials tested with or without previous acid etching of enamel in Class II marginal microleakage was observed (p > 0.05). The use of acid etching prior to self-etching adhesives did not interfere on the microleakage of methacrylate- or silorane-based restorations.

  7. Modulated regeneration of acid-etched human tooth enamel by a functionalized dendrimer that is an analog of amelogenin.

    Science.gov (United States)

    Chen, Mei; Yang, Jiaojiao; Li, Jiyao; Liang, Kunneng; He, Libang; Lin, Zaifu; Chen, Xingyu; Ren, Xiaokang; Li, Jianshu

    2014-10-01

    In the bioinspired repair process of tooth enamel, it is important to simultaneously mimic the organic-matrix-induced biomineralization and increase the binding strength at the remineralization interface. In this work, a fourth-generation polyamidoamine dendrimer (PAMAM) is modified by dimethyl phosphate to obtain phosphate-terminated dendrimer (PAMAM-PO3H2) since it has a similar dimensional scale and peripheral functionalities to that of amelogenin, which plays important role in the natural development process of enamel. Its phosphate group has stronger affinity for calcium ion than carboxyl group and can simultaneously provide strong hydroxyapatite (HA)-binding capability. The MTT assay demonstrates the low cytotoxicity of PAMAM-PO3H2. Adsorption tests indicate that PAMAM-PO3H2 can be tightly adsorbed on the human tooth enamel. Scanning electron microscopy and X-ray diffraction are used to analyze the remineralization process. After being incubated in artificial saliva for 3weeks, there is a newly generated HA layer of 11.23μm thickness on the acid-etched tooth enamel treated by PAMAM-PO3H2, while the thickness for the carboxyl-terminated one (PAMAM-COOH) is only 6.02μm. PAMAM-PO3H2 can regulate the remineralization process to form ordered new crystals oriented along the Z-axis and produce an enamel prism-like structure that is similar to that of natural tooth enamel. The animal experiment also demonstrates that PAMAM-PO3H2 can induce significant HA regeneration in the oral cavity of rats. Thus PAMAM-PO3H2 shows great potential as a biomimetic restorative material for human tooth enamel. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  8. Mixed matrix membranes with HF acid etched ZSM-5 for ethanol/water separation: Preparation and pervaporation performance

    Science.gov (United States)

    Zhan, Xia; Lu, Juan; Tan, Tingting; Li, Jiding

    2012-10-01

    The mixed matrix membranes (MMMs) were prepared from crosslinked PDMS incorporated with HF acid etched ZSM-5. ZSM-5 zeolite was etched with a series of HF aqueous-acetone solution and characterized by SEM, BET, XRD and FT-IR. It was found that HF etching process was very effective for removing organic impurities in zeolite and micro-pores were observed out of the surface of zeolite particles, which enhanced the hydrophobicity and surface roughness of ZSM-5 successfully. Both tensile strength and swelling resistance of ZSM-5/PDMS MMMs increased with the rising concentration of HF solution, which can mainly be attributed to the improved zeolite-PDMS interfacial adhesion resulted from the intrusion of PDMS into micro-pores out of the ZSM-5 surface. Subsequently, the sorption experiment was performed with the results suggesting preferential sorption of ethanol by MMMs. Moreover, the sorption selectivity of ZSM-5/PDMS MMMs increased notably as the concentration of HF solution increased. The pervaporation performance of ethanol/water mixtures using MMMs was also investigated in detail. The MMMs filled with etched ZSM-5 showed much better selectivity than that filled with non-etched ones, with a little expense of permeability. It was found that with the same zeolite loading, increasing the HF acid concentration in etching process enhanced the zeolite-PDMS interfacial adhesion which promoted the ethanol selectivity of MMMs, while depressed the total permeation flux a little. In addition, both ethanol permeation and the selectivity increased with an increase of the zeolite loading from 10% to 30%. Nevertheless, excessive zeolite loading or decreasing thickness of selective layer led to the poor selectivity to ethanol. A decline of the ethanol selectivity was also observed as the feed ethanol concentration as well as feed temperature increased.

  9. 241-AY Double Shell Tanks (DST) Integrity Assessment Report

    Energy Technology Data Exchange (ETDEWEB)

    JENSEN, C.E.

    1999-09-21

    This report presents the results of the integrity assessment of the 241-AY double-shell tank farm facility located in the 200 East Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations. are made to ensure the continued safe operation of the tanks.

  10. 241-AZ Double Shell Tanks (DST) Integrity Assessment Report

    Energy Technology Data Exchange (ETDEWEB)

    JENSEN, C.E.

    1999-09-21

    This report presents the results of the integrity assessment of the 241-A2 double-shell tank farm facility located in the 200 East Area of the Hanford Site. The assessment included the design evaluation and integrity examinations of the tanks and concluded that the facility is adequately designed, is compatible with the waste, and is fit for use. Recommendations including subsequent examinations, are made to ensure the continued safe operation of the tanks.

  11. A comparative evaluation of retention of pit and fissure sealants placed with conventional acid etching and Er,Cr:YSGG laser etching: A randomised controlled trial.

    Science.gov (United States)

    Kumar, Gyanendra; Dhillon, Jatinder Kaur; Rehman, Ferah

    2016-12-30

    Aim: The aim of this study was to compare the retention rates of sealant placed either with conventional acid etching or Er,Cr:YSGG laser pretreatment of enamel surface. Materials and methods: This is a prospective, single blind randomised controlled clinical trial enrolling 200 permanent first molars in 50 patients, aged 6-12 years for sealant placement. Study followed split mouth design where each side of the arch was randomly allocated to the two treatment group. Group A(Acid etch group): 37 % phosphoric acid (Scotchbond, 3M ESPE, Seefeld, Germany) was applied for 15 seconds, rinsed with water for 20 seconds and then air-dried using air spray. Group L(Laser etch group): Fissures were prepared with an Er,Cr:YSGG laser system (Waterlase, BIOLASE Technology, San Clemente, CA, USA) emitting photons at a wavelength of 2.78 µm. Laser irradiation at 1.5 W (60% air and 40% water), in a noncontact mode, with a repetition rate of 20 Hz for 10seconds was used. Pit and fissure sealant (3M ESPE, Clinpro) was applied and cured for 20 seconds. One blinded, calibrated examiner, who was unaware of which preparation method has been used and who was not involved in the treatment procedures, evaluated the sealant at baseline and at 3, 6, 9 and 12 month follow-up visits. Results: It was observed that overall retention rate in group A was slightly higher as compared to group L at all time periods, however, the difference was statistically non-significant (p-value>0.05). Er,Cr:YSGG laser etching is comparable to acid etching in terms of retention and patient acceptability.

  12. Shear Bond Strength of Self-etching Adhesives to Cavities Prepared by Diamond Bur or Er,Cr:YSGG Laser and Effect of Prior Acid Etching.

    Science.gov (United States)

    Jhingan, Pulkit; Sachdev, Vinod; Sandhu, Meera; Sharma, Karan

    2015-12-01

    To compare and evaluate shear bond strength of self-etching adhesives bonded to cavities prepared by diamond bur or Er,Cr:YSGG laser and the effect of prior acid etching on shear bond strength. Ninety-six caries-free human premolars were selected and divided into 2 groups depending on mode of cavity preparation (48 teeth each). Cavities were prepared with Er,Cr:YSGG laser in group 1 and diamond burs in an air-turbine handpiece in group 2. Groups 1 and 2 were further subdivided into three subgroups of 8 teeth each, which were bonded with sixth- or seventh-generation adhesives with or without prior acid etching, followed by restoration of all samples with APX Flow. These samples were subjected to shear bond strength testing. In addition, the surface morphology of 24 samples each from groups 1 and 2 was evaluated using SEM. Data were analyzed using the Shapiro-Wilk test, one- and two-way ANOVA, the t-test, and the least significant difference test, which showed that the data were normally distributed (p > 0.05). The shear bond strength of adhesives in cavities prepared by Er,Cr:YSGG laser was significantly higher than in diamond bur-prepared cavities (p conventional bur-prepared teeth. The Er,Cr:YSGG laser-ablated surface proved to be more receptive for adhesion than those prepared by diamond bur irrespective of the bonding agent used. Seventh-generation adhesives yielded higher shear bond strength than did sixth-generation adhesives. Prior acid etching decreased the shear bond strength of self-etching adhesives.

  13. Surface engineering on continuous VO2 thin films to improve thermochromic properties: Top-down acid etching and bottom-up self-patterning.

    Science.gov (United States)

    Wang, Ning; Peh, Yew Keat; Magdassi, Shlomo; Long, Yi

    2018-02-15

    Surface engineering is an effective method to improve the thermochromic performance of VO2. In this paper, an acid-etching top down method was proposed to tailor the VO2 surface morphology from the continuous dense-packed surface to patterned structure, which exhibited the enhanced integrated visible transmittance (Tlum) and the enlarged solar modulating abilities (ΔTsol). Moreover, a self-patterning approach was also illustrated to improve the thermochromic properties. The proposed surface engineering methods represent a facile and cost-effective approach for enhancing thermochromic properties that could promote the application of VO2 thin films in smart windows. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Comparison of effectiveness of traditional acid etching and of the self-etching agent in sealant retention: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Imran Pasha Mohammed

    2016-01-01

    Full Text Available Introduction: The caries-preventive effect of pit and fissure sealants was demonstrated in the 1970s and the 1980s with randomized clinical trials using parallel groups or split-mouth designs. In new self-etching (SE adhesive systems, rinsing and drying steps are eliminated which have made etching easier and have resulted in more patient acceptability. Aim: To evaluate sealant retention, following application of SE adhesive and traditional acid etching (TAE were carried out among 6–13 years old schoolchildren in Bengaluru city. Materials and Methods: Lower first molars were allotted to either SE adhesive group or TAE group based on lottery method, using a split-mouth technique. The sealants were evaluated for the retention based on modified color coverage caries criteria at the end of 6-month interval by a blinded examiner. Data were analyzed using Wilcoxon tests (P < 0.05. Results: No statistically significant difference was seen in the retention of fissure sealants placed on occlusal surfaces following the use of an SE bonding agent and traditional phosphoric acid etching technique, after 6 months. Conclusions: SE adhesive used for sealing permanent molars of young children for a limited period, should be reviewed every 6 months.

  15. Hazard assessments of double-shell flammable gas tanks

    Energy Technology Data Exchange (ETDEWEB)

    Fox, G.L.; Stepnewski, D.D.

    1994-09-28

    This report is the fourth in a series of hazard assessments performed on the double-shell flammable gas watch list tanks. This report focuses on hazards associated with the double-shell watch list tanks (101-AW, 103-AN, 104-AN, and 105-AN). While a similar assessment has already been performed for tank 103-SY, it is also included here to incorporate a more representative slurry gas mixture and provide a consistent basis for comparing results for all the flammable gas tanks. This report is intended to provide an in-depth assessment by considering the details of the gas release event and slurry gas mixing as the gas is released from the waste. The consequences of postulated gas ignition are evaluated using a plume burn model and updated ignition frequency predictions. Tank pressurization which results from a gas burn, along with the structural response, is also considered. The report is intended to support the safety basis for work activities in flammable gas tanks by showing margins to safety limits that are available in the design and procedures.

  16. Microleakage assessment of fissure sealant following fissurotomy bur or pumice prophylaxis use before etching

    Directory of Open Access Journals (Sweden)

    Ali Bagherian

    2013-01-01

    The aim of this investigation was to compare the microleakage level of fissure sealants prepared by a fissurotomy bur or pumice prophylaxis prior to acid etching. Materials and Methods: Ninety freshly extracted healthy maxillary premolar teeth were randomly selected for this investigation. Teeth were then divided into three fissure sealant preparatory groups of A: Fissurotomy bur + acid etch; B: Pumice prophylaxis + acid etch and C: Acid etch alone. Sealant was applied to the occlusal fissures of all specimens using a plastic instrument. This was to avoid any air trap under the sealant. Sample teeth were first thermocycled (1000 cycles, 20 s dwell time and then coated with two layers of nail varnish leaving 2 mm around the sealant. This was then followed by immersion in basic fuchsin 3%. Processed teeth were sectioned longitudinally and examined under a stereomicroscope for microleakage assessment using a score of 0-3. Collected data was then subjected to Kruskall-Wallis Analysis of Variance and Mann-Whitney U-test. P < 0.05 was considered as significant. Results: Teeth in fissurotomy bur and pumice prophylaxis groups had significantly reduced level of microleakage than those in acid etch alone (P = 0.005 and P = 0.003, respectively. Conclusion: Use of fissurotomy bur and pumice prophylaxis accompanied with acid etching appears to have a more successful reduction of microleakage than acid etch alone.

  17. Effects of Nano-Hydroxyapatite/Polyetheretherketone-Coated, Sandblasted, Large-Grit, and Acid-Etched Implants on Inflammatory Cytokines and Osseointegration in a Peri-Implantitis Model in Beagle Dogs

    Science.gov (United States)

    Yang, Hua-Wei; Tang, Xiao-Shan; Tian, Zhuo-Wei; Wang, Yang; Yang, Wen-Yi; Hu, Jing-Zhou

    2017-01-01

    Background This study explored the effects of nano-hydroxyapatite/polyetheretherketone (n-HA/PEEK)-coated sandblasted, large-grit, and acid-etched (SLA) implants on inflammatory cytokines and osseointegration in peri-implantitis model beagle dogs. Material/Methods Peri-implantitis models were established. Eight beagle dogs were randomly and evenly assigned into SLA tied, SLA + n-HA/PEEK tied, SLA untied, or SLA + n-HA/PEEK untied groups. A special periodontal probe was used to detect the plaque index (PLI), probing depth (PD), and modified Sulcus Bleeding Index (mSBI). Gingival crevicular fluid was collected and an ELISA kit was utilized to detect IL-1, IL-6, and IL-17 levels. The colony-forming units were counted and the maximum shear strength of implants was tested using the axial pullout test. HE staining was used to detect the inflammation of peri-implant bone tissues. Osseointegration was observed through toluidine blue staining. Bone-to-implant contact (BIC) was obtained through histological observation and the mineral apposition rate (MAR) was calculated after immune fluorescent double staining. Results The SLA tied group demonstrated higher levels of PLI, PD, mSBI, IL-1, IL-6, and IL-17 and a higher degree of inflammation than the SLA + n-HA/PEEK tied group. The tied groups also displayed similar results over the untied groups at the same time point. The maximum shear strength, BIC, and MAR in the SLA tied group were significantly lower than in the SLA + n-HA/PEEK tied group. Conclusions Our findings demonstrate that SLA + n-HA/PEEK implants can promote osseointegration and relieve the inflammation response of peri-implantitis in beagle dogs. PMID:28945699

  18. Peri-Implant Endosseous Healing Properties of Dual Acid-Etched Mini-Implants with a Nanometer-Sized Deposition of CaP : A Histological and Histomorphometric Human Study

    NARCIS (Netherlands)

    Telleman, Gerdien; Albrektsson, Tomas; Hoffman, Maria; Johansson, Carina B.; Vissink, Arjan; Meijer, Henny J. A.; Raghoebar, Gerry M.

    2010-01-01

    Purpose: The aim of this histological and histomorphometric study was to compare the early peri-implant endosseous healing properties of a dual acid-etched (DAE) surface (Osseotite (R), Implant Innovations Inc., Palm Beach Gardens, FL, USA) with a DAE surface modified with nanometer-sized calcium

  19. Efficacy of standard (SLA) and modified sandblasted and acid-etched (SLActive) dental implants in promoting immediate and/or early occlusal loading protocols: a systematic review of prospective studies.

    Science.gov (United States)

    Chambrone, Leandro; Shibli, Jamil Awad; Mercúrio, Carlos Eduardo; Cardoso, Bruna; Preshaw, Philip M

    2015-04-01

    To assess the survival percentage, clinical and radiographic outcomes of sandblasted and acid-etched (SLA) dental implants and its modified surface (SLActive) in protocols involving immediate and early occlusal loading. MEDLINE, EMBASE and the Cochrane Oral Health Group's Trials Register CENTRAL were searched in duplicate up to, and including, June 2013 to include randomised controlled trials (RCTs) and prospective observational studies of at least 6-month duration published in all languages. Studies limited to patients treated with SLA and/or SLActive implants involving a treatment protocol describing immediate and early loading of these implants were eligible for inclusion. Data on clinical and/or radiographic outcomes following implant placement were considered for inclusion. Of the 447 potentially eligible publications identified by the search strategy, seven RCTs comprising a total of 853 implants (8% titanium plasma-sprayed, 41.5% SLA and 50.5% SLActive) and 12 prospective observational studies including 1394 SLA and 145 SLActive implants were included in this review. According to the Cochrane Collaboration's tool for assessing risk of bias, one of the studies was considered to be at a low risk of bias, whereas the remaining studies were considered to be at an unclear risk. Regarding the observational studies, all of them presented a medium methodological quality based on the Modified Newcastle-Ottawa scale. There were no significant differences reported in the studies in relation to implant loss or clinical parameters between the immediate/early loading and delayed loading protocols. Overall, 95% of SLA and 97% of SLActive implants still survive at the end of follow-up. Despite of the positive findings achieved by the included studies, few RCTs were available for analysis for SLActive implants. Study heterogeneity, scarcity of data and the lack of pooled estimates represent a limitation between studies' comparisons and should be considered when interpreting

  20. Bone Response to Two Dental Implants with Different Sandblasted/Acid-Etched Implant Surfaces: A Histological and Histomorphometrical Study in Rabbits

    Directory of Open Access Journals (Sweden)

    Antonio Scarano

    2017-01-01

    Full Text Available Background. Scientific evidence in the field of implant dentistry of the past 20 years established that titanium rough surfaces have shown improved osseointegration rates. In a majority of dental implants, the surface microroughness was obtained by grit blasting and/or acid etching. The aim of the study was to evaluate in vivo two different highly hydrophilic surfaces at different experimental times. Methods. Calcium-modified (CA and SLActive surfaces were evaluated and a total of 18 implants for each type of surface were positioned into the rabbit articular femoral knee-joint in a split model experiment, and they were evaluated histologically and histomorphometrically at 15, 30, and 60 days of healing. Results. Bone-implant contact (BIC at the two-implant surfaces was significantly different in favor of the CA surface at 15 days (p=0.027, while SLActive displayed not significantly higher values at 30 (p=0.51 and 60 days (p=0.061. Conclusion. Both implant surfaces show an intimate interaction with newly formed bone.

  1. Resistance to fracture of endodontically treated premolars restored with glass ionomer cement or acid etch composite resin: An in vitro study

    Directory of Open Access Journals (Sweden)

    B Ranga

    2010-01-01

    Full Text Available Aim: Due to the weakness of endodontically treated posterior teeth requires more strengthened restoration to withstand occlusal forces. The purpose of the present study was to determine and compare the resistance to fracture of endodontically treated maxillary 1 st premolars restored with different materials in mesio-occluso-distal (MOD cavity preparations. Materials and Methods: MOD cavity preparations in 80 endodontically treated maxillary 1 st premolars were restored using four different methods. Fiber rings were filled with stone plaster and the teeth were placed into the plaster up to the level of cemento-enamel junction. The teeth were grouped according to restorative method, mounted in an Instrom T.T. machine, and the buccal walls subjected to a slowly increasing compressive force until fracture occurred. Result: The force of fracture of the walls of each tooth was recorded and the results in the various groups compared. All teeth fractured in a similar manner irrespective of the restorative method used. Conclusion: The resistance to the fracture of the teeth was the same when they were stored with glass ionomer cement as a base over which composite resin was placed. When the entire cavities were filled with glass ionomer cement, the resistance to fracture of the teeth decreased significantly compared with the acid etch resin technique.

  2. Comparative Study of the Early Loading of Resorbable Blasting Media and Sandblasting with Large-grit and Acid-etching Surface Implants: A Retrospective Cohort Study

    Science.gov (United States)

    Kim, Sung-Beom; Kim, Young-Kyun; Kim, Su-Gwan; Oh, Ji-Su; Kim, Byung-Hoon

    2014-01-01

    Purpose: This study compares the prognosis (the survival rate and marginal bone loss) of resorbable blasting media (RBM) surface implants and sandblasting with large-grit and acid-etching (SLA) surface implants in the early loading. Methods: This study targeted 123 patients treated by implants installation from January 2008 to March 2010. The loading was initiated in the maxilla within three to four months and in the mandible within one to two months. The types of restoration were single crown and fixed partial prosthesis. Those functioned over one year. The implants were classified by the surface of implants as Group 1: RBM surface (GS III; OSSTEM, Busan, Korea) and, Group 2: SLA surface (Superline; Dentium, Seoul, Korea). The groups were categorized by maxilla and mandible and compared by survival rate, marginal bone loss through clinical records evaluation, and radiographic measurements. Results: The marginal bone loss in the maxilla was 0.14±0.34 mm (Group 1) and 0.30±0.37 mm (Group 2), a statistically significant difference (P 0.05). There was no significant difference of marginal bone loss between maxilla and mandible by groups. During observation there was no implant failure, a survival rate of 100%. Conclusion: Both surfaces showed an excellent survival rate, and the marginal bone loss was not substantial. PMID:27489842

  3. [Doppler color ultrasonography in the assessment of double kidney transplantation].

    Science.gov (United States)

    Selvaggio, Oscar; Martino, Pasquale; Palazzo, Silvano; Battaglia, Michele; Ditonno, Pasquale; Di Lorenzo, Vito; Selvaggi, Francesco Paolo

    2002-12-01

    In our Transplant Centre, in the last three years, twelve patients with chronic kidney disease underwent a "double kidney" transplant according to Masson technique. Our purpose is the evaluation of ultrasonography and echo-colorDoppler ultrasound in the diagnosis of possible clinical and surgical complications of "double kidney" transplant. The "double kidney" transplant inclusion criteria are the following: donor age > 70 yrs; glomerulosclerosis > 20%; histological score (according to Kandinsky) > 4 and 0.80 (mean 0.82); patients without DGF (group B) had an IR < 0.80 (mean 0.68 and 0.65) (p < 0.05). All patients underwent an eco colorDoppler evaluation after 3 and 6 months; in both groups (A and B) IR was, respectively, 0.75 and 0.71. Surgical adverse events were 41.6% (5/12): 3 urinary obstructions; 1 thrombosis of renal vein; 1 pelvic lymphocele. In all these patients the first diagnostic step was ultrasonography. Ultrasonography, in "double transplant" as in single one, have a very important role in post-transplant evaluation of DGF and surgical complications.

  4. Controlled-release of bone morphogenetic protein-2 from a microsphere coating applied to acid-etched Ti6AL4V implants increases biological bone growth in vivo.

    Science.gov (United States)

    Fu, Yangmu; Zhang, Qiang; Sun, Yong; Liao, Weixiong; Bai, Xiaowei; Zhang, Lili; Du, Lina; Jin, Yiguang; Wang, Qi; Li, Zhongli; Wang, Yan

    2014-06-01

    A central clinical challenge regarding the surgical treatment of bone and joint conditions is the eventual loosening of an orthopedic implant as a result of insufficient bone ingrowth at the bone-implant interface. We investigated the in vivo effectiveness of a coating containing recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded microspheres applied to acid-etched Ti6Al4V cylinders for implantation. Three groups of rabbits (24 per group) were used for implantation: (1) acid-etched Ti6Al4V implants coated with a mixture of rhBMP-2-loaded microspheres (125 ng rhBMP-2/mg microspheres) and α-butyl cyanoacrylate; (2) acid-etched, uncoated implants; and (3) bare, smooth uncoated implants. After implantation, 12 rabbits from each group were used for bone ingrowth determination at 4, 5, 6, 7, 8, and 12 weeks (2 rabbits per time point), while the remainder were used for histological analysis and push-out testing at 12 weeks. Scanning electron microscopy showed significant improvement in bone growth of the rhBMP-2 microspheres/α-butyl cyanoacrylate group compared with the other groups (p<0.01). Histological analysis and push-out testing also demonstrated enhanced bone growth of the rhBMP-2 group over that in the other two groups (p<0.01). The rhBMP-2 group showed the most significant bone growth, suggesting that coating acid-etched implants with a mixture of rhBMP-2-loaded microspheres and α-butyl cyanoacrylate may be an effective method to improve the osseointegration of orthopedic implants. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  5. Micro-shear bond strength and surface micromorphology of a feldspathic ceramic treated with different cleaning methods after hydrofluoric acid etching

    Directory of Open Access Journals (Sweden)

    Henrique Caballero STEINHAUSER

    2014-04-01

    Full Text Available Objective: The aim of this study was to evaluate the effect of feldspathic ceramic surface cleaning on micro-shear bond strength and ceramic surface morphology. Material and Methods: Forty discs of feldspathic ceramic were prepared and etched with 10% hydrofluoric acid for 2 minutes. The discs were randomly distributed into five groups (n=8: C: no treatment, S: water spray + air drying for 1 minute, US: immersion in ultrasonic bath for 5 minutes, F: etching with 37% phosphoric acid for 1 minute, followed by 1-minute rinse, F+US: etching with 37% phosphoric acid for 1 minute, 1-minute rinse and ultrasonic bath for 5 minutes. Composite cylinders were bonded to the discs following application of silane and hydrophobic adhesive for micro-shear bond strength testing in a universal testing machine at 0.5 mm/min crosshead speed until failure. Stereomicroscopy was used to classify failure type. Surface micromorphology of each treatment type was evaluated by scanning electron microscopy at 500 and 2,500 times magnification. Results: One-way ANOVA test showed no significant difference between treatments (p=0.3197 and the most common failure types were cohesive resin cohesion followed by adhesive failure. Micro-shear bond strength of the feldspathic ceramic substrate to the adhesive system was not influenced by the different surface cleaning techniques. Absence of or less residue was observed after etching with hydrofluoric acid for the groups US and F+US. Conclusions: Combining ceramic cleaning techniques with hydrofluoric acid etching did not affect ceramic bond strength, whereas, when cleaning was associated with ultrasound, less residue was observed.

  6. Rehabilitation of irradiated patients with modified and conventional sandblasted acid-etched implants: preliminary results of a split-mouth study.

    Science.gov (United States)

    Heberer, Susanne; Kilic, Sevtap; Hossamo, Jaber; Raguse, Jan-Dirk; Nelson, Katja

    2011-05-01

    The aim of this study was to evaluate the success rate of chemically modified and conventional sandblasted acid-etched surface (SLA) titanium implants in irradiated oral squamous cell carcinoma patients. Twenty patients with a mean age of 61.1 years were treated with dental implants after ablative surgery and radio-chemotherapy of oral cancer. All patients were non-smokers. The placement of SLA and modSLA implants was performed bilaterally according to a split-mouth design. All 102 implants (50 SLA, 52 modSLA) placed showed an unloaded healing time of 6 weeks in the mandible and 10 weeks in the maxilla. Mean crestal bone changes using standardized orthopantomographies and clinical parameters like pocket depths, mPII and mBI were evaluated. Of 102 implants, 55 implants (27 SLA implants, 28 modSLA) were located in the maxilla and 47 implants (23 SLA, 24 modSLA) in the mandible. The average observation period was 14.4 months. The amount of bone loss at the implant shoulder of SLA implants was 0.4 mm mesial and 0.4 mm distal. The modSLA implants displayed a bone loss of mesial 0.3 mm and distal 0.3 mm. Two SLA implants were lost resulting in a success rate of 96%. The success rate of modSLA implants was 100%. Regarding the data found in this investigation, we can conclude that implants with chemically modified and conventional SLA titanium surface show high success rates in irradiated patients. SLA implants with or without a chemically modified surface regardless of the location can be restored with a high predictability of success at least in the short time range observed. © 2010 John Wiley & Sons A/S.

  7. Assessing Thermal Comfort Due to a Ventilated Double Window

    Science.gov (United States)

    Carlos, Jorge S.; Corvacho, Helena

    2017-10-01

    Building design and its components are the result of a complex process, which should provide pleasant conditions to its inhabitants. Therefore, indoor acceptable comfort is influenced by the architectural design. ISO and ASHRAE standards define thermal comfort as the condition of mind that expresses satisfaction with the thermal environment. The energy demand for heating, beside the building’s physical properties, also depend on human behaviour, like opening or closing windows. Generally, windows are the weakest façade element concerning to thermal performance. A lower thermal resistance allows higher thermal conduction through it. When a window is very hot or cold, and the occupant is very close to it, it may result in thermal discomfort. The functionality of a ventilated double window introduces new physical considerations to a traditional window. In consequence, it is necessary to study the local effect on human comfort in function of the boundary conditions. Wind, solar availability, air temperature and therefore heating and indoor air quality conditions will affect the relationship between this passive system and the indoor environment. In the present paper, the influence of thermal performance and ventilation on human comfort resulting from the construction and geometry solutions is shown, helping to choose the best solution. The presented approach shows that in order to save energy it is possible to reduce the air changes of a room to the minimum, without compromising air quality, enhancing simultaneously local thermal performance and comfort. The results of the study on the effect of two parallel windows with a ventilated channel in the same fenestration on comfort conditions for several different room dimensions, are also presented. As the room dimensions’ rate changes so does the window to floor rate; therefore, under the same climatic conditions and same construction solution, different results are obtained.

  8. Prospective randomized assessment of single versus double-gloving for general surgical procedures.

    Science.gov (United States)

    Na'aya, H U; Madziga, A G; Eni, U E

    2009-01-01

    There is increased tendency towards double-gloving by general surgeons in our practice, due probably to awareness of the risk of contamination with blood or other body fluids during surgery. The aim of the study was to compare the relative frequency of glove puncture in single-glove versus double glove sets in general surgical procedures, and to determine if duration of surgery affects perforation rate. Surgeons at random do single or double gloves at their discretion, for general surgical procedures. All the gloves used by the surgeons were assessed immediately after surgery for perforation. A total of 1120 gloves were tested, of which 880 were double-glove sets and 240 single-glove sets. There was no significant difference in the overall perforation rate between single and double glove sets (18.3% versus 20%). However, only 2.3% had perforations in both the outer and inner gloves in the double glove group. Therefore, there was significantly greater risk for blood-skin exposure in the single glove sets (p < 0.01). The perforation rate was also significantly greater during procedures lasting an hour or more compared to those lasting less than an hour (p < 0.01). Double-gloving reduces the risk of blood-skin contamination in all general surgical procedures, and especially so in procedures lasting an hour or more.

  9. Bone changes around early loaded chemically modified sandblasted and acid-etched surfaced implants with and without a machined collar: a radiographic and resonance frequency analysis in the canine mandible.

    Science.gov (United States)

    Valderrama, Pilar; Jones, Archie A; Wilson, Thomas G; Higginbottom, Frank; Schoolfield, John D; Jung, Ronald E; Noujeim, Marcel; Cochran, David L

    2010-01-01

    The purpose of this study was to evaluate the radiographic bone level and stability changes around early loaded chemically modified sandblasted and acid-etched implants with and without a machined collar. Seventy-two chemically modified sandblasted and acid-etched implants 4.1 mm in diameter and 8 mm in length were placed in six dogs. Thirty-six implants had no machined collar (NMC) and 36 had a 2.8-mm machined collar (MC). Resonance frequency measurements were obtained at placement and weekly for 3 weeks. All implants were loaded 21 days after surgery. Standardized periapical radiographs were obtained at baseline, at 3 weeks, and at 3, 6, 9, and 12 months. The radiographs were randomized and digitized, and linear measurements of the distance from the first bone-to-implant contact to the shoulder of the implant were performed at the mesial and distal aspects of each implant. For statistical analysis, mixed-model repeated-measures analysis of variance was used. All implants achieved hard and soft tissue integration clinically and radiographically and were clinically immobile. From placement to week 3, the mean implant stability increased for MC implants by more than 5 ISQs and for NMC implants by more than 7 ISQs. Radiographically, there were significant differences between treatment groups beginning at 3 months. After 12 months of loading, the MC implants presented a mean bone loss of 1.00 mm and the NMC implants presented a mean bone gain of 0.11 mm. Chemically modified sandblasted and acid-etched implants without a machined collar presented bone gain, and implants with a machined collar showed bone loss after a 1 year following early (21-day) loading. The tendency toward a coronal apposition of bone observed under these conditions may be attributed to the osteoconductive properties of the chemically modified surfaces of these implants and to the absence of the machined collar.

  10. Ultimate Limit State Assessment of Timber Bolt Connection Subjected to Double Unequal Shears

    Science.gov (United States)

    Musilek, Josef; Plachy, Jan

    2017-10-01

    Nowadays the problems occur when a structure engineer need to assess the ultimate limit state of timber bolt connection which is subjected to double unequal shears. This assessment of ultimate limit state shows the reliability of these connections. In assessing the reliability of this connection in ultimate limit state is a problem, because the formulas and equations that are currently available in design standards and available literature, describing only connections loaded symmetrically – this mean that they describe the timber bolt connection subjected to double equal shears. This fact causes problems because structural engineers have no available support, according to which they could assess reliability of the connection in terms of the ultimate limit state. They must therefore often report following an asymmetrically loaded connections carry about using formulas, which are primarily designed for checking connections loaded symmetrically. This leads logically to the fact that it is not respected by the actual behaviour of the connection in the ultimate limit state. Formulas derived in this paper provide the possibility to assess the ultimate limit state for such connection. The formulas derived in this article allow to carry out a reliability assessment of the ultimate limit state of timber bolt connection subjected to double shear. The using of the formulas derived in this paper leads to better description of the behaviour of this type of connection and also to the more economic design. An example of using these derived formulas is shown. There is shown in this example, how to assess the reliability of timber bolt connection subjected to double unequal shears in terms of ultimate limit states.

  11. Asteroid Impact and Deflection Assessment (AIDA) Mission: The double Asteroid redirection test (DART)

    OpenAIRE

    Cheng, A F; Michel, P; Barnouin, O.S.; Campo-Bagatin, A.; Miller, P.; Pravec, P.; Richardson, D. C.; Rivkin, A. S.; Schwartz, S.R.; Stickel, A.; Tsiganis, K.; Ulamec, S.

    2016-01-01

    The Asteroid Impact & Deflection Assessment (AIDA) mission will be the first space experiment to demonstrate asteroid impact hazard mitigation by using a kinetic impactor. AIDA is a joint ESA-NASA cooperative project [1,2], that includes the ESA Asteroid Impact Mission (AIM) rendezvous spacecraft and the NASA Double Asteroid Redirection Test (DART) mission. The AIDA target is the near- Earth binary asteroid 65803 Didymos, which will make an unusually close approach to Earth in October, 20...

  12. A twelve-month clinical trial comparing the bracket failure rates of light-cured resin-modified glass-ionomer adhesive and acid-etch chemical-cured composite.

    Science.gov (United States)

    Fowler, P V

    1998-10-01

    A clinical study was undertaken to compare the failure rate over a twelve-month period of orthodontic brackets bonded with a light-cured resin-modified glass-ionomer (Fuji Ortho LC-GC International Japan) and an acid-etch chemically-cured two-paste composite (Orthodontic Concise-3M USA). Failure rates of 6.1 per cent and 5.4 per cent respectively were reported, with no statistically significant difference between the two adhesives. This finding, along with the relative ease of use and possible advantages of reduced risk of peri-bracket demineralisation, suggests that the resin-modified glass-ionomer adhesive may become more popular as a bracket adhesive.

  13. Environmental assessment for double tracks test site, Nevada Test Site, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The U.S. Department of Energy, Nevada Operations Office (DOE/NV), with appropriate approvals from the U.S. Air Force (USAF), proposes to conduct environmental restoration operations at the Double Tracks test site located on the Nellis Air Force Range (NAFR) in Nye County, Nevada. This environmental assessment (EA) evaluates the potential environmental consequences of four alternative actions for conducting the restoration operation and of the no action alternative. The EA also identifies mitigation measures, where appropriate, designed to protect natural and cultural resources and reduce impacts to human health and safety. The environmental restoration operation at the Double Tracks test site would serve two primary objectives. First, the proposed work would evaluate the effectiveness of future restoration operations involving contamination over larger areas. The project would implement remediation technology options and evaluate how these technologies could be applied to the larger areas of contaminated soils on the Nevada Test Site (NTS), the Tonopah Test Range (TTR), and the NAFR. Second, the remediation would provide for the removal of plutonium contamination down to or below a predetermined level which would require cleanup of 1 hectare (ha) (2.5 acres), for the most likely case, or up to 3.0 ha (7.4 acres) of contaminated soil, for the upper bounding case.

  14. Performance assessment on grouted double-shell tank waste at Hanford

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, D.H; McNair, G.W. [Pacific Northwest Lab., Richland, WA (United States); Allison, J.M. [Westinghouse Hanford Co., Richland, WA (United States)

    1989-11-01

    The low-level fraction of liquid waste stored in double-shell tanks at Hanford will be solidified in a cementitious matrix (grout) and disposed in subsurface vaults. This paper discusses activities related to the preparation of a site-specific performance assessment as required by DOE Order 5820.2A. A draft performance assessment has been prepared for the planned grout disposal system at Hanford using site-specific data. The assessment estimates the incremental increase in the dose to future populations who, after loss of institutional control at the site, use groundwater downgradient of the disposal site. Increases in nonradiological species in water from a hypothetical well are also estimated. Two-dimensional transport models were used to estimate contaminant concentrations in groundwater. Based on diffusional release from the waste package, the projected radiological dose to an individual on a hypothetical farm using water from a well at the disposal facility boundary is estimated at less than one percent of the 25 mrem/yr standard in Order 5820.2. Technetium accounted for about 95% of the dose. Nitrate was the principle chemical contaminant at 0.3% to 0.5% of apportioned drinking water standards. Sensitivity studies on various parameters are in progress. This performance assessment will be updated as additional data become available.

  15. Improved bonding of adhesive resin to sintered porcelain with the combination of acid etching and a two-liquid silane conditioner.

    Science.gov (United States)

    Kato, H; Matsumura, H; Ide, T; Atsuta, M

    2001-01-01

    This study determined the bond strengths of adhesive resins joined to a feldspathic porcelain (VMK 68) for the purpose of developing the most durable surface preparation for the porcelain. Three porcelain surfaces-ground, air-abraded with alumina, and etched with hydrofluoric acid-were prepared. A two-liquid porcelain conditioner that contained both 4-methacryloyloxyethyl trimellitate anhydride (4-META) and a silane coupler (Porcelain Liner M) was used as the priming agent. Each of the two liquid components of the conditioner was also used individually in order to examine the effects of the respective chemical ingredients on adhesive bonding. Two methyl methacrylate (MMA)-based resins initiated with tri-n-butylborane (TBB) either with or without 4-META (MMA-TBB and 4-META/MMA-TBB resins) were used as the luting agents. Shear bond strengths were determined both before and after thermocycling. Shear testing results indicated that thermocycling was effective for disclosing poor bonding systems, and that both mechanical and chemical retention were indispensable for bonding the porcelain. Of the combinations assessed, etching with hydrofluoric acid followed by two-liquid priming with the Porcelain Liner M material generated the most durable bond strength (33.3 MPa) for the porcelain bonded with the 4-META/MMA-TBB resin (Super-Bond C&B).

  16. Experiencing Double-Bind Conflict: A Semantic Differential Assessment of Interaction Perceptions

    Science.gov (United States)

    Helm, Bob; And Others

    1976-01-01

    Four interaction-perception perspectives of the fictitious target of a double-bind conflict were provided by four groups of subjects. The perspectives included perceptions of a daughter about herself and her father (the double-bind source), and her estimates of his perceptions of both himself and her. (Editor)

  17. Assessing farmers’ perceptions about climate change: A double-hurdle approach

    Directory of Open Access Journals (Sweden)

    Patrick Hitayezu

    2017-01-01

    Full Text Available Drawing from insights of the behavioural decision research, this study applies a double-hurdle (DH estimation technique to assess social-psychological factors influencing the likelihood of perceiving climate risk and, given positive perception, the perceived patterns of climate change (CC among farmers in KwaZulu-Natal, South Africa. The model employs survey data collected from 352 small-scale farmers, 68% of whom had recognized CC, as indicated by perceptions of abnormal weather. Dominant perceptions are analysed using a principal component analysis technique and appraised based on meteorological records. The results point to higher probabilities of perceiving climate risk among farmers who experience more emotive mental imagery and those with stronger egalitarian values. The results further suggest that farmers who perceive CC based on affective impression and direct personal experience are more likely to suffer cognitive bias in their perceptions compared to farmers who perceive climate risk based on knowledge and analytic processing of climate information. Based on these findings, recommendations for effective CC communication policy are outlined.

  18. Decision making based on single and double acceptance sampling plans for assessing quality of lots

    OpenAIRE

    Ksenija Dumičic

    2012-01-01

    Background: Acceptance sampling is a statistical tool of quality control. Sampling plans and operating characteristic (OC) curves are very useful for conducting acceptance sampling and provide the quality manager with tools to evaluate the quality of a production run or shipment. There are developed different sampling plans, but common used in practise are single and double acceptance sampling plans. Objectives: The goal of the paper is to test if applying of single and double sampling plan c...

  19. Safety and Efficacy Assessment of Two New Leprosy Skin Test Antigens: Randomized Double Blind Clinical Study

    Science.gov (United States)

    Rivoire, Becky L.; Groathouse, Nathan A.; TerLouw, Stephen; Neupane, Kapil Dev; Ranjit, Chaman; Sapkota, Bishwa Raj; Khadge, Saraswoti; Kunwar, Chatra B.; Macdonald, Murdo; Hawksworth, Rachel; Thapa, Min B.; Hagge, Deanna A.; Tibbals, Melinda; Smith, Carol; Dube, Tina; She, Dewei; Wolff, Mark; Zhou, Eric; Makhene, Mamodikoe; Mason, Robin; Sizemore, Christine; Brennan, Patrick J.

    2014-01-01

    Background New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in human trials. Methods A Phase I safety trial was first conducted in a non-endemic region for leprosy (U.S.A.). Healthy non-exposed subjects (n = 10) received three titrated doses (2.5 µg, 1.0 µg and 0.1 µg) of MLSA-LAM (n = 5) or MLCwA (n = 5) and control antigens [Rees MLSA (1.0 µg) and saline]. A randomized double blind Phase II safety and efficacy trial followed in an endemic region for leprosy (Nepal), but involved only the 1.0 µg (high dose) and 0.1 µg (low dose) of each antigen; Tuberculin PPD served as a control antigen. This Phase II safety and efficacy trial consisted of three Stages: Stage A and B studies were an expansion of Phase I involving 10 and 90 subjects respectively, and Stage C was then conducted in two parts (high dose and low dose), each enrolling 80 participants: 20 borderline lepromatous/lepromatous (BL/LL) leprosy patients, 20 borderline tuberculoid/tuberculoid (BT/TT) leprosy patients, 20 household contacts of leprosy patients (HC), and 20 tuberculosis (TB) patients. The primary outcome measure for the skin test was delayed type hypersensitivity induration. Findings In the small Phase I safety trial, reactions were primarily against the 2.5 µg dose of both antigens and Rees control antigen, which were then excluded from subsequent studies. In the Phase II, Stage A/B ramped-up safety study, 26% of subjects (13 of 50) showed induration against the high dose of each antigen, and 4% (2 of 50) reacted to the low dose of MLSA-LAM. Phase II, Stage C safety and initial efficacy trial showed that both antigens at the low dose exhibited low sensitivity at 20% and 25% in BT/TT leprosy patients, but high specificity at 100% and 95% compared to TB patients. The high dose of both antigens

  20. Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study.

    Directory of Open Access Journals (Sweden)

    Becky L Rivoire

    Full Text Available New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in human trials.A Phase I safety trial was first conducted in a non-endemic region for leprosy (U.S.A.. Healthy non-exposed subjects (n = 10 received three titrated doses (2.5 µg, 1.0 µg and 0.1 µg of MLSA-LAM (n = 5 or MLCwA (n = 5 and control antigens [Rees MLSA (1.0 µg and saline]. A randomized double blind Phase II safety and efficacy trial followed in an endemic region for leprosy (Nepal, but involved only the 1.0 µg (high dose and 0.1 µg (low dose of each antigen; Tuberculin PPD served as a control antigen. This Phase II safety and efficacy trial consisted of three Stages: Stage A and B studies were an expansion of Phase I involving 10 and 90 subjects respectively, and Stage C was then conducted in two parts (high dose and low dose, each enrolling 80 participants: 20 borderline lepromatous/lepromatous (BL/LL leprosy patients, 20 borderline tuberculoid/tuberculoid (BT/TT leprosy patients, 20 household contacts of leprosy patients (HC, and 20 tuberculosis (TB patients. The primary outcome measure for the skin test was delayed type hypersensitivity induration.In the small Phase I safety trial, reactions were primarily against the 2.5 µg dose of both antigens and Rees control antigen, which were then excluded from subsequent studies. In the Phase II, Stage A/B ramped-up safety study, 26% of subjects (13 of 50 showed induration against the high dose of each antigen, and 4% (2 of 50 reacted to the low dose of MLSA-LAM. Phase II, Stage C safety and initial efficacy trial showed that both antigens at the low dose exhibited low sensitivity at 20% and 25% in BT/TT leprosy patients, but high specificity at 100% and 95% compared to TB patients. The high dose of both antigens showed lower specificity (70% and 60

  1. Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study.

    Science.gov (United States)

    Rivoire, Becky L; Groathouse, Nathan A; TerLouw, Stephen; Neupane, Kapil Dev; Ranjit, Chaman; Sapkota, Bishwa Raj; Khadge, Saraswoti; Kunwar, Chhatra B; Kunwar, Chatra B; Macdonald, Murdo; Hawksworth, Rachel; Thapa, Min B; Hagge, Deanna A; Tibbals, Melinda; Smith, Carol; Dube, Tina; She, Dewei; Wolff, Mark; Zhou, Eric; Makhene, Mamodikoe; Mason, Robin; Sizemore, Christine; Brennan, Patrick J

    2014-01-01

    New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in human trials. A Phase I safety trial was first conducted in a non-endemic region for leprosy (U.S.A.). Healthy non-exposed subjects (n = 10) received three titrated doses (2.5 µg, 1.0 µg and 0.1 µg) of MLSA-LAM (n = 5) or MLCwA (n = 5) and control antigens [Rees MLSA (1.0 µg) and saline]. A randomized double blind Phase II safety and efficacy trial followed in an endemic region for leprosy (Nepal), but involved only the 1.0 µg (high dose) and 0.1 µg (low dose) of each antigen; Tuberculin PPD served as a control antigen. This Phase II safety and efficacy trial consisted of three Stages: Stage A and B studies were an expansion of Phase I involving 10 and 90 subjects respectively, and Stage C was then conducted in two parts (high dose and low dose), each enrolling 80 participants: 20 borderline lepromatous/lepromatous (BL/LL) leprosy patients, 20 borderline tuberculoid/tuberculoid (BT/TT) leprosy patients, 20 household contacts of leprosy patients (HC), and 20 tuberculosis (TB) patients. The primary outcome measure for the skin test was delayed type hypersensitivity induration. In the small Phase I safety trial, reactions were primarily against the 2.5 µg dose of both antigens and Rees control antigen, which were then excluded from subsequent studies. In the Phase II, Stage A/B ramped-up safety study, 26% of subjects (13 of 50) showed induration against the high dose of each antigen, and 4% (2 of 50) reacted to the low dose of MLSA-LAM. Phase II, Stage C safety and initial efficacy trial showed that both antigens at the low dose exhibited low sensitivity at 20% and 25% in BT/TT leprosy patients, but high specificity at 100% and 95% compared to TB patients. The high dose of both antigens showed lower specificity (70% and 60

  2. Decision making based on single and double acceptance sampling plans for assessing quality of lots

    Directory of Open Access Journals (Sweden)

    Ksenija Dumičic

    2012-01-01

    Full Text Available Background: Acceptance sampling is a statistical tool of quality control. Sampling plans and operating characteristic (OC curves are very useful for conducting acceptance sampling and provide the quality manager with tools to evaluate the quality of a production run or shipment. There are developed different sampling plans, but common used in practise are single and double acceptance sampling plans. Objectives: The goal of the paper is to test if applying of single and double sampling plan can lead to statistically significant different conclusion about quality level of observed lot. Methods/Approach: Statistical tests of difference in proportions are used to test if there is some statistically significant difference in probabilities of lot fraction defectives between a single and a double sampling plan at the same levels of probability of acceptance. Results: The results of the analysis show that in some cases there is statistically significant difference. Namely, the quality manager should be careful when he chooses to use, instead of the first, the second sampling plan with different parameters because on that way he could make statistically significant different conclusion about quality level of observed lot. Conclusions: The paper shows that some intentional manipulations by using different sampling plans are possible.

  3. Assessment of organizational culture of enterprise university by the model "The cube double c" of R. Goffi and G. Jones's

    Directory of Open Access Journals (Sweden)

    Mkrtychyan G.A.

    2017-07-01

    Full Text Available In work the possibility of an assessment of organizational culture of enterprise university by the model "A cube double C" of R. Goffi and G. Jones's is investigated. Selection of respondents consisted of 50 teaching staff of faculties of management and economy of the Nizhny Novgorod campus of Higher School of Economics: 31 women and 19 men; 5 professors, 27 associate professors and 18 senior teachers. Diagnostics like organizational culture was carried out by means of R. Goffi and G. Jones's questionnaire, studying of resistance to the changes which are carried out in higher education institution — by means of an author's questionnaire. In a research it is revealed that the Nizhny Novgorod campus of Higher School of Economics has communal type of culture that conforms to requirements of enterprise university; one of the psychological reasons of resistance of teachers to the changes which are carried out to the organizations is their discrepancy to the academic values; the weak organizational culture of a campus causes resistance to the carried-out organizational changes. The research has shown that the model of organizational culture "A cube double C" is the adequate tool of an assessment of culture of enterprise university.

  4. Double-shell tank integrity assessments ultrasonic test equipment performance test

    Energy Technology Data Exchange (ETDEWEB)

    Pfluger, D.C.

    1996-09-26

    A double-shell tank (DST) inspection (DSTI) system was performance tested over three months until August 1995 at Pittsburgh, Pennsylvania, completing a contract initiated in February 1993 to design, fabricate, and test an ultrasonic inspection system intended to provide ultrasonic test (UT) and visual data to determine the integrity of 28 DSTs at Hanford. The DSTs are approximately one-million-gallon underground radioactive-waste storage tanks. The test was performed in accordance with a procedure (Jensen 1995) that included requirements described in the contract specification (Pfluger 1995). This report documents the results of tests conducted to evaluate the performance of the DSTI system against the requirements of the contract specification. The test of the DSTI system also reflects the performance of qualified personnel and operating procedures.

  5. Empirical Validation of Simple Calculation Method for Assessment of Energy Performance in Double-Skin Façade Building

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Thomas, Sara Jessica; Larsen, Olena Kalyanova

    2009-01-01

    When designing new buildings a Double-Skin Facades (DSF) concept is recurrently discussed as an energy saving solution. There is a strong demand for a tool, which could estimate the energy performance of a DSF building in an early design stage, in order to assess whether it fulfills the Energy...... Performance Building Directive. Therefore, the Bestfacade Project Group has developed the Simple Calculation Method (SCM). In this paper the calculations of DSF performance using SCM are compared against experimental data gathered in a full-scale model for three data-sets from different periods of the year....... The SCM is recommended for assessing a seasonal DSF performance, however, it gives more reliable results if SCM is applied for shorter periods. Detailed calculation results tend to differ from the measurements, mainly due to overestimating the cooling demand. The validation described in this paper led...

  6. Assessing the Prevalence of Publication Misconduct among Iranian Authors Using a Double List Experiment.

    Science.gov (United States)

    Hadji, Maryam; Asghari, Fariba; Yunesian, Masoud; Kabiri, Payam; Fotouhi, Akbar

    2016-07-01

    This study was done to determine the prevalence of publication misconduct among Iranian authors. Data were collected through an email survey of corresponding authors of papers published in Iranian journals indexed in Scopus during 2009-2011. Using the double list experiment, these individuals were indirectly questioned about committing one of the five misconducts including duplicate publication, falsification, guest authorship, plagiarism, and fabrication over the past year. The survey was sent to 2321 individuals; 100 emails bounced, and of the remaining, 813 (36.60%) people responded to the questions. The prevalence rates were 4.15% for fabrication, 4.90% for plagiarism, 18.10% for guest authorship, 12.65% for falsification of the study methods, and -5.40% for duplicate publication. Among respondent 56.50% trusted the method and confidentiality of the survey and 6.50% did not trust the method or confidentiality at all. We found that the double list experiment method is simple and reliable for use in the academic community, and it can be conducted easily in an e-survey. According to our results, the most common misconducts among Iranian authors are guest authorship and falsification of the methodology. In light of the negative and maleficent impact of publication misconduct in the scientific society, we recommend raising awareness and educating authors and investigators in this regard. To determine the accuracy of the method used in this study, further studies on publication misconduct using a control group and direct questioning, as well as other indirect methods are suggested.

  7. Performance assessment on a variety of double side structure during collision interaction with other ship

    Science.gov (United States)

    Prabowo, Aditya Rio; Sohn, Jung Min; Bae, Dong Myung; Cho, Joung Hyung

    2017-09-01

    The main goal of the present paper was to study the physical response of a double side skin (DSS) structure under impact load in a collision event between two ships. Collision energy and damage extent (size and location) during the collision process were observed together with damage patterns on side structure. The ships were modeled after a Ro-Ro passenger ship and cargo reefer which were involved in a ship collision on the Sunda Strait while the analyseswere performed using non-linear simulations FEMto produce virtual simulation data. Several caseswere proposed to be investigated in this work with involvement of parameters i.e. penetration location and ship materials which were embedded on the structure model. A series of material experiments and testing was conducted to obtain detailed material properties which were to be deployed in simulation. It was shown that, after penetration at the transition location, the striking ship was successfully deforming and forming tears to the inner skin. On the other hand, with identical structure and identical mass of construction, the use of high-strength low-alloy (HSLA) steel as the repair material offered considerably better capacity in absorbing the impact load than plain-carbon steel.

  8. Radon and material radiopurity assessment for the NEXT double beta decay experiment

    Science.gov (United States)

    Cebrián, S.; Pérez, J.; Bandac, I.; Labarga, L.; Álvarez, V.; Barrado, A. I.; Bettini, A.; Borges, F. I. G. M.; Camargo, M.; Cárcel, S.; Cervera, A.; Conde, C. A. N.; Conde, E.; Dafni, T.; Díaz, J.; Esteve, R.; Fernandes, L. M. P.; Fernández, M.; Ferrario, P.; Freitas, E. D. C.; Fernandes, L. M. P.; Gehman, V. M.; Goldschmidt, A.; Gómez-Cadenas, J. J.; González-Díaz, D.; Gutiérrez, R. M.; Hauptman, J.; Morata, J. A. Hernando; Herrera, D. C.; Irastorza, I. G.; Laing, A.; Liubarsky, I.; López-March, N.; Lorca, D.; Losada, M.; Luzón, G.; Marí, A.; Martín-Albo, J.; Martínez, A.; Martínez-Lema, G.; Miller, T.; Monrabal, F.; Monserrate, M.; Monteiro, C. M. B.; Mora, F. J.; Moutinho, L. M.; Vidal, J. Muñoz; Nebot-Guinot, M.; Nygren, D.; Oliveira, C. A. B.; de Solórzano, A. Ortiz; Aparicio, J. L. Pérez; Querol, M.; Renner, J.; Ripoll, L.; Rodríguez, J.; Santos, F. P.; dos Santos, J. M. F.; Serra, L.; Shuman, D.; Simón, A.; Sofka, C.; Sorel, M.; Toledo, J. F.; Torrent, J.; Tsamalaidze, Z.; Veloso, J. F. C. A.; Villar, J. A.; Webb, R. C.; White, J. T.; Yahlali, N.

    2015-08-01

    The "Neutrino Experiment with a Xenon TPC" (NEXT), intended to investigate the neutrinoless double beta decay using a high-pressure xenon gas TPC filled with Xe enriched in 136Xe at the Canfranc Underground Laboratory in Spain, requires ultra-low background conditions demanding an exhaustive control of material radiopurity and environmental radon levels. An extensive material screening process is underway for several years based mainly on gamma-ray spectroscopy using ultra-low background germanium detectors in Canfranc but also on mass spectrometry techniques like GDMS and ICPMS. Components from shielding, pressure vessel, electroluminescence and high voltage elements and energy and tracking readout planes have been analyzed, helping in the final design of the experiment and in the construction of the background model. The latest measurements carried out will be presented and the implication on NEXT of their results will be discussed. The commissioning of the NEW detector, as a first step towards NEXT, has started in Canfranc; in-situ measurements of airborne radon levels were taken there to optimize the system for radon mitigation and will be shown too.

  9. Radon and material radiopurity assessment for the NEXT double beta decay experiment

    Energy Technology Data Exchange (ETDEWEB)

    Cebrián, S.; Dafni, T.; González-Díaz, D.; Herrera, D. C.; Irastorza, I. G.; Luzón, G.; Ortiz de Solórzano, A.; Villar, J. A. [Laboratorio de Física Nuclear y Astropartículas, Universidad de Zaragoza, C/ Pedro Cerbuna 12, 50009 Zaragoza (Spain); Laboratorio Subterráneo de Canfranc, Paseo de los Ayerbe s/n, 22880 Canfranc Estación, Huesca (Spain); Pérez, J. [Instituto de Física Teórica, UAM/CSIC, Campus de Cantoblanco, 28049 Madrid (Spain); Bandac, I. [Laboratorio Subterráneo de Canfranc, Paseo de los Ayerbe s/n, 22880 Canfranc Estación, Huesca (Spain); Labarga, L. [Dpto. de Física Teórica, Universidad Autónoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain); Álvarez, V.; Cárcel, S.; Cervera, A.; Díaz, J.; Ferrario, P.; Gómez-Cadenas, J. J.; Laing, A.; Liubarsky, I.; López-March, N. [Instituto de Física Corpuscular, CSIC & Universitat de València, C/ Catedrático José Beltrán, 2, 46980 Paterna, Valencia (Spain); and others

    2015-08-17

    The ”Neutrino Experiment with a Xenon TPC” (NEXT), intended to investigate the neutrinoless double beta decay using a high-pressure xenon gas TPC filled with Xe enriched in {sup 136}Xe at the Canfranc Underground Laboratory in Spain, requires ultra-low background conditions demanding an exhaustive control of material radiopurity and environmental radon levels. An extensive material screening process is underway for several years based mainly on gamma-ray spectroscopy using ultra-low background germanium detectors in Canfranc but also on mass spectrometry techniques like GDMS and ICPMS. Components from shielding, pressure vessel, electroluminescence and high voltage elements and energy and tracking readout planes have been analyzed, helping in the final design of the experiment and in the construction of the background model. The latest measurements carried out will be presented and the implication on NEXT of their results will be discussed. The commissioning of the NEW detector, as a first step towards NEXT, has started in Canfranc; in-situ measurements of airborne radon levels were taken there to optimize the system for radon mitigation and will be shown too.

  10. Performance assessment on a variety of double side structure during collision interaction with other ship

    Directory of Open Access Journals (Sweden)

    Prabowo Aditya Rio

    2017-09-01

    Full Text Available The main goal of the present paper was to study the physical response of a double side skin (DSS structure under impact load in a collision event between two ships. Collision energy and damage extent (size and location during the collision process were observed together with damage patterns on side structure. The ships were modeled after a Ro-Ro passenger ship and cargo reefer which were involved in a ship collision on the Sunda Strait while the analyseswere performed using non-linear simulations FEMto produce virtual simulation data. Several caseswere proposed to be investigated in this work with involvement of parameters i.e. penetration location and ship materials which were embedded on the structure model. A series of material experiments and testing was conducted to obtain detailed material properties which were to be deployed in simulation. It was shown that, after penetration at the transition location, the striking ship was successfully deforming and forming tears to the inner skin. On the other hand, with identical structure and identical mass of construction, the use of high-strength low-alloy (HSLA steel as the repair material offered considerably better capacity in absorbing the impact load than plain-carbon steel.

  11. Electrical Double-Layer Capacitors in Hybrid Topologies —Assessment and Evaluation of Their Performance

    Directory of Open Access Journals (Sweden)

    Joeri Van Mierlo

    2012-11-01

    Full Text Available PHEVs and BEVs make use of battery cells optimized for high energy rather than for high power. This means that the power abilities of these batteries are limited. In order to enhance their performance, a hybrid Rechargeable Energy Storage System (RESS architecture can be used combining batteries with electrical-double layer capacitors (EDLCs. Such a hybridized architecture can be accomplished using passive or active systems. In this paper, the characteristics of these topologies have been analyzed and compared based on a newly developed hybridization simulation tool for association of lithium-ion batteries and EDLCs. The analysis shows that the beneficial impact of the EDLCs brings about enhanced battery performances in terms of energy efficiency and voltage drops, rather than extension of vehicle range. These issues have been particularly studied for the passive and active hybrid topologies. The classical passive and active topologies being expensive and less beneficial in term of cost, volume and weight, a new hybrid configuration based on the parallel combination of lithium-ion and EDLCs on cell level has been proposed in this article. This topology allows reducing cost, volume, and weight and system complexity in a significant way. Furthermore, a number of experimental setups have illustrated the power of the novel topology in terms of battery capacity increase and power capabilities during charging and discharging. Finally, a unique cycle life test campaign demonstrated that the lifetime of highly optimized lithium-ion batteries can be extended up to 30%–40%.

  12. Assessment of tetanus immunity status by tetanus quick stick and anamnesis: a prospective double blind study.

    Science.gov (United States)

    Orsi, G B; Modini, C; Principe, M A; Di Muzio, M; Moriconi, A; Amato, M G; Calderale, S M

    2015-01-01

    In patients with wounds admitted to Emergency Departments (ED) acquiring tetanus vaccination history by interview is very unreliable. Protected patients may receive unnecessary prophylaxis and unprotected nothing. Aim of the study was to evaluate tetanus immunity status comparing the traditional anamnestic method with the Tetanus Quick Stick (TQS), a rapid immunochromatographic test. A double-blind prospective study was carried out in the ED of the 1,000 bed teaching hospital Umberto I in Rome. Adult patients (≥18) with wounds attending at the ED were randomly included. Tetanus immunity status was evaluated by healthcare workers (HCWs) comparing the TQS test with the anamnesis. TQS test was performed by a trained HCW and afterwards the anamnesis about tetanus immunity status was collected by another HCW unaware of the TQS result. Also cost analysis was carried out. Overall 400 patients (242 males and 158 females) were included, mean age was 46.7 ± 20.2 years (median 44 range 18 - 109), 304 (76.0%) were italians and 96 foreigners (24.0%). Overall, 209 (52.2%) resulted TQS +, and protective immunity level was associated to lower mean age (40.1 ± 16.8 vs 53.8 ± 21,1; pimmunity is inversely related to age, for immunity prevalence among adult patients attending our ED is about 50% and is mainly influenced by class age. TQS use allowed to reduce drastically inappropriate tetanus vaccine and immunoglobulins booster treatment. Also TQS use reduced costs.

  13. Interface Fracture Toughness Assessment of Solder Joints Using Double Cantilever Beam Test

    Science.gov (United States)

    Loo, Shane Zhi Yuan; Lee, Puay Cheng; Lim, Zan Xuan; Yantara, Natalia; Tee, Tong Yan; Tan, Cher Ming; Chen, Zhong

    In the current work, a test scheme to evaluate solder joint interface fracture toughness using double cantilever beam (DCB) test has been successfully demonstrated. The obtained results, in terms of critical energy release rate, predict the joint failure based on the principle of fracture mechanics. The results can be used as a materials property in the reliability design of various types of solder-ball joined packages. DCB specimens made of 99.9 wt% copper were selected in the current work. Eutectic Sn-37Pb and lead-free Sn-3.5Ag-0.5Cu solders were used to join two pieces of the copper beams with controlled solder thickness. The test record showed steady propagation of the crack along the solder / copper interface, which verifies the viability of such a testing scheme. Interface fracture toughness for as-joined, extensively-reflowed and thermally aged samples has been measured. Both the reflow treatment and the thermal aging lead to degradation of the solder joint fracture resistance. Reflow treatment was more damaging as it induces much faster interface reaction. Fractographic analysis established that the fracture has a mixed micromechanism of dimple and cleavage. The dimples are formed as a result of the separation between the hard intermetallic compound (IMC) particles and the soft solder material, while the cleavage is formed by the brittle split of the IMCs. When the IMC thickness is increased due to extended interface reaction, the proportion of IMC cleavage failure increases, and this was reflected in the decrease of the critical energy release rate.

  14. Double fluorescent flow cytometric assessment of bacterial internalization and binding by epithelial cells

    NARCIS (Netherlands)

    de Boer, E. C.; Bevers, R. F.; Kurth, K. H.; Schamhart, D. H.

    1996-01-01

    This study describes a new flow cytometric method for assessment of phagocytosis of specific bacteria (bacillus Calmette-Guérin (BCG) and Escherichia coli) by bladder epithelial cells. The internalization assay consisted of labeling bacteria chemically with fluorescein isothiocyanate (FITC).

  15. Discrepant screening mammography assessments at blinded and non-blinded double reading: impact of arbitration by a third reader on screening outcome.

    Science.gov (United States)

    Klompenhouwer, Elisabeth G; Voogd, Adri C; den Heeten, Gerard J; Strobbe, Luc J A; Tjan-Heijnen, Vivianne C; Broeders, Mireille J M; Duijm, Lucien E M

    2015-10-01

    To determine the value of adding a third reader for arbitration of discrepant screening mammography assessments. We included a consecutive series of 84,927 digital screening mammograms, double read in a blinded or non-blinded fashion. Arbitration was retrospectively performed by a third screening radiologist. Two years' follow-up was performed. Discrepant readings comprised 57.2% (830/1452) and 29.1% (346/1188) of recalls at blinded and non-blinded double readings, respectively. At blinded double reading, arbitration would have decreased recall rate (3.4 to 2.2%, p arbitration would have decreased recall rate (2.8 to 2.3%, p Arbitration of discrepant screening mammography assessments is a good tool to improve recall rate and PPV, but is not desirable as it reduces the programme sensitivity at blinded double reading. • Blinded double reading results in higher programme sensitivity than non-blinded reading. • Discrepant readings occur more often at blinded compared to non-blinded reading. • Arbitration of discrepant readings reduces the recall rate and PPV. • Arbitration would reduce the programme sensitivity at blinded double reading.

  16. Environmental impact assessment of double- and relay-cropping with winter camelina in the northern Great Plains, USA

    Science.gov (United States)

    Recent findings indicate that double- or relay-cropping winter camelina (Camelina sativa L. Crantz.) with feed or food crops can increase yield per area, improve energy balance, and provide several ecosystem services. Double-cropping can help balance food and energy production. The objective of this...

  17. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail in Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Danilo Maciel Carneiro

    2014-01-01

    Full Text Available In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups (n=12 that underwent a three-step treatment. For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900 mg/day, placebo (corn starch, 900 mg/day, or hydrochlorothiazide (25 mg/day, separated by a 10-day washout period. Each volunteer served as his own control, and the groups’ results were compared. We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug. The diuretic effect of EADE was assessed by monitoring the volunteers’ water balance over a 24 h period. The E. arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes. There was no significant increase in the urinary elimination of catabolites. Rare minor adverse events were reported. The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use. Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.

  18. Assessment of Seasonal Energy Efficiency Strategies of a Double Skin Façade in a Monsoon Climate Region

    Directory of Open Access Journals (Sweden)

    Choongwan Koo

    2013-08-01

    Full Text Available As climate change and global warming have become two of the most significant environmental issues today, the double-skin façade (DSF is getting considerable attention as an energy-efficient passive design. This study is aimed at assessing the seasonal energy efficiency strategies of a DSF targeting library facilities in the climate region with hot summers and cold winters. Toward this end, this study was conducted in four steps: (i establishment of seasonal energy-efficient strategies; (ii application of seasonal energy-efficient strategies; (iii analysis of energy saving effect by season; and (iv life cycle cost and life cycle CO2 analyses for selecting an optimal DSF. Results show that a shaft box DSF energy model (EMS #2, which applied winter strategies, was optimal with an energy saving rate of 4.13%, while a multi-story DSF energy model (EMM #5, which applied summer strategies, was optimal with an energy saving rate of 12.67%. In terms of savings to investment ratio (SIR40 and breakeven point (BEP40, the multi-story DSF (3.20; 9 years was superior. The results of this study can be used for (i seasonal energy efficiency strategies of a DSF in East Asian monsoon climates, and (ii as a guideline for the application of a DSF both in existing and new buildings.

  19. Assessment of the Use of Venetian Blinds as Solar Thermal Collectors in Double Skin Facades in Mediterranean Climates

    Directory of Open Access Journals (Sweden)

    Abel Velasco

    2017-11-01

    Full Text Available The global trend on energy integration and building efficiency is making both researchers and building developers look for technical solutions to use facade surfaces for energy harvesting. In this work, the assessment of the thermal performance of a double-skin facade (DSF with a venetian blind-type of structure used as a solar thermal collector by means of computational fluid dynamics (CFD is presented. A Venetian blind collector would allow for heat rejection/energy harvesting and exterior views simultaneously and can be easily integrated into the DSF aesthetical design. For the purposes of this study, the modeled facades (south, west, and east-oriented were set to be located in Barcelona (Spain, where large solar gains are a constant condition throughout the year, and such large semi-transparent envelopes lead to interior over-heating in buildings, even during the winter. For the studied facades, both the reductions in radiative heat gains entering the building and the heat recovery in the Venetian blind collector were evaluated for a yearlong operation.

  20. Seismic assessment of a temporary deployment in the Kingdom of Bhutan using double-­difference tomography

    Science.gov (United States)

    Perez, C. A.; Velasco, A. A.; Syracuse, E. M.; Maceira, M.; Zhang, H.

    2014-12-01

    The Kingdom of Bhutan is located on the eastern edge of the Himalaya range. As an area of a major continental-continental collision, Bhutan Himalaya has been subject to a considerable amount of deformation and transpression, and it contains features of the five major shear zones of the Himalayas. Extensive seismic analysis of the region, however, is lacking due to sparse coverage and complexity of its crustal structure. We examine seismic event data from a temporary seismic network deployed in the Kingdom of Bhutan (2002-2003) using the double difference tomographic inversion technique TomoFDD, which allows for the joint inversion of event relocations and seismic velocity structure. Our primary focus is on ~200 regional events surrounding the five-station network. The events are located between 86° and 100°E longitude, and 18° and 31°N latitude, and with depths between 10 and 400 km. To extend our model area, we also incorporate GSN stations LSA, KMI, and CHTO. Prior analysis of this dataset consisted of event location, relocation, and 1D velocity modeling. We leverage on previous studies and build a new 3D seismic velocity model of the crust and upper mantle underneath the Bhutan region to gain further insight on the seismicity and crustal assessment.

  1. Assessment of the presumed mapping function approach for the stationary laminar flamelet modelling of reacting double scalar mixing layers

    Science.gov (United States)

    El Sayed, Ahmad; Mortensen, Mikael; Wen, John Z.

    2014-09-01

    This paper assesses the Presumed Mapping Function (PMF) approach in the context of the Stationary Laminar Flamelet Modelling (SLFM) of a reacting Double Scalar Mixing Layer (DSML). Starting from a prescribed Gaussian reference field, the PMF approach provides a presumed Probability Density Function (PDF) for the mixture fraction that is subsequently employed to close the Conditional Scalar Dissipation Rate (CSDR) upon doubly-integrating the homogeneous PDF transport equation. The PMF approach is unique in its ability to yield PDF and CSDR distributions that capture the effect of multiple fuel injections of different composition. This distinct feature overcomes the shortcomings of the classical SLFM closures (the β-distribution for the PDF and the counterflow solution for the CSDR). The current study analyses the impact of the binary (two-stream) and trinary (three-stream) PMF approaches on the structure of laminar flamelets in a DSML formed by the mixing of a fuel stream and an oxidiser stream separated by a pilot. The conditions of a partially-premixed methane/air piloted jet flame are considered. A parametric assessment is performed by varying the local mixing statistics and the findings are compared to those of the classical SLFM approach. Further, the influence of the PMF approach on flamelet extinction and transport by means of differential diffusion is thoroughly investigated. It is shown that the trinary PMF approach captures the influence of the pilot stream as it is capable of yielding bimodal CSDR and trimodal PDF distributions. It is further demonstrated that, when the influence of the pilot is significant, flamelets generated using the trinary CSDR closure extinguish at higher strain levels compared to flamelets generated using the binary and counterflow closures. Lastly, it is shown that the trinary PMF approach can be critical for accurate SLFM computations of DSMLs when differential diffusion effects are important.

  2. Assessment of abuse liability of Tramadol among experienced drug users: Double-blind crossover randomized controlled trial.

    Science.gov (United States)

    Das, Mrinmay; Jain, Raka; Dhawan, Anju; Kaur, Amandeep

    Tramadol is a widely used opioid analgesic. Different preclinical, clinical, and postmarketing surveillance studies show conflicting results regarding abuse potential of this drug. A randomized double-blind complete crossover study was conducted at National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi. Total subjects were 10, comprising total 120 observations (each subject assessed at baseline, 5, 45, and 240 minutes). Subjects with history of substance abuse were included after detoxification and informed consent. Assessment was done using modified single dose opiate questionnaire, morphine benzedrine group (MBG), pentobarbital chlorpromazine alcohol group (PCAG), and two bipolar visual analogue scales (VAS) after administration of three drugs-Tramadol (100 mg), Buprenorphine (0.6 mg), and Placebo (Normal Saline) intramuscularly, at 5-day interval. In intra-group analysis, there was statistically significant increase in scores of all four scales from baseline to all three time points after Tramadol and Buprenorphine administration. In inter-group analysis, statistically higher scores were seen for Buprenorphine in comparison to Tramadol at 5, 45, and 240 minutes for MBG scale; the score was significantly higher for Buprenorphine in VAS for pleasurable effect at 45 and 240 minutes, but not at baseline and 5 minutes. There was no significant difference in score at any point of time between Tramadol and Buprenorphine in PCAG scale and VAS for sedative/alertness effect. The scores were statistically insignificant in case of Placebo. All the subjects liked Buprenorphine most and then Tramadol followed by Placebo. Tramadol has abuse potential (even in therapeutic doses) more than Placebo but less than or comparable to Buprenorphine.

  3. Prevalence of the "double-line" sign when performing focused assessment with sonography in trauma (FAST) examinations.

    Science.gov (United States)

    Patwa, Amy Shah; Cipot, Steven; Lomibao, Alvin; Nelson, Mathew; Bramante, Robert; Modayil, Veena; Haines, Christine; Ash, Adam; Raio, Christopher

    2015-09-01

    The double-line sign (DLS) is a wedge-shaped hypoechoic area in Morison's pouch bounded on both sides by echogenic lines. It represents a false-positive finding for free intraperitoneal fluid when performing focused assessment with sonography in trauma examinations. The purpose of this study was to determine the prevalence of DLS. Secondarily, the study will further investigate the relationship between the presence of a DLS and body mass index (BMI). This was a prospective study that enrolled patients over a 7-month period. Inclusion criteria were patients ≥ 18 years of age presenting to the Emergency Department (ED) requiring a FAST examination as part of the patient's standard medical care. Each examination was performed by one of six experienced ultrasonographers. Presence or absence of the DLS was established in real time and gender, height, weight, and BMI were recorded for each patient. The overall prevalence rate of DLS and the corresponding 95 % confidence interval were calculated, as well as the prevalence rates broken down by BMI characterized as underweight, normal weight, overweight, and obese; and age category (18-29, 30-64, and 65+). The Chi-square test and a Fisher's exact test for BMI category were used to compare the prevalence rates of positive DLS among the different demographic groups. 100 patients were enrolled in the study; the overall prevalence was 27 %. There was no statistical significance among the different demographic groups or BMI. The DLS is a prevalent finding. We believe this sign has become more apparent due to improved imaging technology and resolution.

  4. Assessment of T-shape double fascia graft for lower lip deformity from facial paralysis: A questionnaire survey.

    Science.gov (United States)

    Hayashi, Ayato; Yoshizawa, Hidekazu; Natori, Yuhei; Suda, Shunichi; Mochizuki, Mariko; Nishimuta, Yuri; Tanaka, Rica; Mizuno, Hiroshi

    2016-03-01

    There are two main methods to treat lower-lip deformity (LLD) in facial paralysis. The first method is surgical intervention on the side of the paralysis, and the second involves denervating the depressor muscles on the healthy side. It is sometimes difficult for patients to ethically accept the denervating healthy tissue; therefore, we performed the T-shape double fascia graft (TSDFG), which reportedly restores symmetry. In this study, we report our experience with TSDFG and evaluation of the outcomes including the patient questionnaires. Two fascia strips from the thigh, 7 × 70 mm in size, were used; one was grafted horizontally at the lower lip to correct the static position, and the other was grafted obliquely at the lateral side by folding and crossing the horizontal fascia. A total of nine patients were treated by this procedure; three procedures were performed individually and six were performed in combination with another static or reanimation procedure. A questionnaire containing a five-point scoring system for facial appearance in multiple situations and other problems was sent to each patient at least 6 months after the surgery. From the physicians' point of view, all patients achieved an improvement in symmetry of the lower lip, particularly when opening of the mouth; however, assessments from the patients demonstrated much less satisfaction. The main reason for the dissatisfaction was the slight bulkiness of the red lip. There was one comment that noted that with more treatment, the expectations were higher, and, as a result, the patient could not admit satisfaction at the end. TSDFG is a simple and effective procedure for LLD; however, slight modifications may be required. In addition, there were some gaps in the perception of the results between the physicians and patients, and we need to consider these when planning to treat LLD. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All

  5. Two-Dimensional Layered Double Hydroxide Derived from Vermiculite Waste Water Supported Highly Dispersed Ni Nanoparticles for CO Methanation

    Directory of Open Access Journals (Sweden)

    Panpan Li

    2017-03-01

    Full Text Available Expanded multilayered vermiculite (VMT was successfully used as catalyst support and Ni/VMT synthesized by microwave irradiation assisted synthesis (MIAS exhibited excellent performance in our previous work. We also developed a two-dimensional porous SiO2 nanomesh (2D VMT-SiO2 by mixed-acid etching of VMT. Compared with three-dimensional (3D MCM-41, 2D VMT-SiO2 as a catalyst support provided a superior position for implantation of NiO species and the as-obtained catalyst exhibited excellent performance. In this paper, we successfully synthesized a layered double hydroxide (LDH using the spent liquor after mixed-acid etching of VMT, which mainly contained Mg2+ and Al3+. The as-calcined layered double oxide (LDO was used as a catalyst support for CO methanation. Compared with Ni/MgAl-LDO, Ni/VMT-LDO had smaller active component particles; therefore, in this study, it exhibited excellent catalytic performance over the whole temperature range of 250–500 °C. Ni/VMT-LDO achieved the best activity with 87.88% CO conversion, 89.97% CH4 selectivity, and 12.47 × 10−2·s−1 turn over frequency (TOF at 400 °C under a gas hourly space velocity of 20,000 mL/g/h. This study demonstrated that VMT-LDO as a catalyst support provided an efficient way to develop high-performance catalysts for synthetic natural gas (SNG from syngas.

  6. A high spatial resolution double-pulse Thomson scattering diagnostic; description, assessment of accuracy and examples of applications

    NARCIS (Netherlands)

    Beurskens, M. N. A.; Barth, C. J.; Cardozo, N. J. L.; van der Meiden, H. J.

    1999-01-01

    A high spatial resolution (3 mm full width half maximum, i.e. 2% of the minor radius) double-pulse multiposition Thomson scattering system was in operation at the Rijnhuizen tokamak project RTP from March 1996 until September 1998. It upgrades the previously installed single-pulse Thomson scattering

  7. A milestone in the doubled haploid pathway of cassava: a milestone in the doubled haploid pathway of cassava (Manihot esculenta Crantz): cellular and molecular assessment of anther-derived structures.

    Science.gov (United States)

    Perera, P I P; Ordoñez, C A; Lopez-Lavalle, L A Becerra; Dedicova, B

    2014-01-01

    This study was aimed at inducing androgenesis in cultured anthers of cassava (Manihot esculenta Crantz) to develop a protocol for the production of doubled haploids. Microspore reprogramming was induced in cassava by cold or heat stress of anthers. Since the anthers contain both haploid microspores and diploid somatic cells, it was essential to verify the origin of anther-derived calli. The origin of anther-derived calli was assessed by morphological screening followed by histological analysis and flow cytometry (FCM). Additionally, simple sequence repeat (SSR) and amplified fragmented length polymorphism (AFLP) assays were used for the molecular identification of the microspore-derived calli. The study clearly demonstrated the feasibility of producing microspore-derived calli using heat- or cold-pretreated anthers. Histological studies revealed reprogramming of the developmental pathway of microspores by symmetrical division of the nucleus. Flow cytometry analysis revealed different ploidy level cell types including haploids, which confirmed their origin from the microspores. The SSR and AFLP marker assays independently confirmed the histological and FCM results of a haploid origin of the calli at the DNA level. The presence of multicellular microspores in the in vitro system indicated a switch of developmental program, which constitutes a crucial step in the design of protocols for the regeneration of microspore-derived embryos and plants. This is the first detailed report of calli, embryos, and abnormal shoots originated from the haploid cells in cassava, leading to the development of a protocol for the production of doubled haploid plants in cassava.

  8. A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout.

    Science.gov (United States)

    Port, Johannes; Tao, Ziran; Junger, Annika; Joppek, Christoph; Tempel, Philipp; Husemann, Kim; Singer, Florian; Latzin, Philipp; Yammine, Sophie; Nagel, Joachim H; Kohlhäufl, Martin

    2017-11-01

    For the assessment of small airway diseases, a noninvasive double-tracer gas single-breath washout (DTG-SBW) with sulfur hexafluoride (SF6) and helium (He) as tracer components has been proposed. It is assumed that small airway diseases may produce typical ventilation inhomogeneities which can be detected within one single tidal breath, when using two tracer components. Characteristic parameters calculated from a relative molar mass (MM) signal of the airflow during the washout expiration phase are analyzed. The DTG-SBW signal is acquired by subtracting a reconstructed MM signal without tracer gas from the signal measured with an ultrasonic sensor during in- and exhalation of the double-tracer gas for one tidal breath. In this paper, a simple method to determine the reconstructed MM signal is presented. Measurements on subjects with and without obstructive lung diseases including the small airways have shown high reliability and reproducibility of this method.

  9. A double blind trial to assess the value of alclofenac compared with phenylbutazone in the management of rheumatoid arthritis.

    Science.gov (United States)

    Chamberlain, M A; Wright, V

    1975-01-01

    A double-blind cross-over study using a double placebo technique was employed to compare the effectiveness of daily alclofenac 3 g and phenylbutazone 300 mg in rheumatoid arthritis. (2) Thirty-one patients with classical or definite rheumatoid arthritis entered the trial. Twenty-three patients completed the trial; eight patients were withdrawn while on alclofenac, six developing a rash and two having inadequate analgesia. (3) Relief of pain on both drugs was comparable. (4) When questioned at the end of the trial, sixteen patients preferred phenylbutazone, four preferred alclofenac. (5) No significant changes in laboratory values were found, apart from a slight mean fall in haemoglobin on phenylbutazone. (6) There were significantly more side effects on alclofenac and rashes were particularly prominent. PMID:237493

  10. Energy Performance Assessment of a 2nd-Generation Vacuum Double Glazing Depending on Vacuum Layer Position and Building Type in South Korea

    National Research Council Canada - National Science Library

    Seung-Chul Kim; Jong-Ho Yoon; Ru-Da Lee

    2017-01-01

    ...: This study compared the heating energy performance of four types of glazing, inside vacuum double glazing, outside vacuum double glazing, single vacuum glazing, and low-e double glazing, with fixed...

  11. Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease.

    Science.gov (United States)

    Orenstein, Susan R; Hassall, Eric; Furmaga-Jablonska, Wanda; Atkinson, Stuart; Raanan, Marsha

    2009-04-01

    To assess the efficacy and safety of lansoprazole in treating infants with symptoms attributed to gastroesophageal reflux disease (GERD) that have persisted despite a >or= 1-week course of nonpharmacologic management. This multicenter, double-blind, parallel-group study randomized infants with persisting symptoms attributed to GERD to treatment with lansoprazole or placebo for 4 weeks. Symptoms were tracked through daily diaries and weekly visits. Efficacy was defined primarily by a >or= 50% reduction in measures of feeding-related crying and secondarily by changes in other symptoms and global assessments. Safety was assessed based on the occurrence of adverse events (AEs) and clinical/laboratory data. Of the 216 infants screened, 162 met the inclusion/exclusion criteria and were randomized. Of those, 44/81 infants (54%) in each group were responders--identical for lansoprazole and placebo. No significant lansoprazole-placebo differences were detected in any secondary measures or analyses of efficacy. During double-blind treatment, 62% of lansoprazole-treated subjects experienced 1 or more treatment-emergent AEs, versus 46% of placebo recipients (P= .058). Serious AEs (SAEs), particularly lower respiratory tract infections, occurred in 12 infants, significantly more frequently in the lansoprazole group compared with the placebo group (10 vs 2; P= .032). This study detected no difference in efficacy between lansoprazole and placebo for symptoms attributed to GERD in infants age 1 to 12 months. SAEs, particularly lower respiratory tract infections, occurred more frequently with lansoprazole than with placebo.

  12. Double-echo perfusion-weighted MR imaging: basic concepts and application in brain tumors for the assessment of tumor blood volume and vascular permeability.

    Science.gov (United States)

    Uematsu, Hidemasa; Maeda, Masayuki

    2006-01-01

    Perfusion-weighted magnetic resonance (MR) imaging using contrast agents plays a key role in characterizing tumors of the brain. We have shown that double-echo perfusion-weighted MR imaging (DEPWI) is potentially useful in assessing brain tumors. Quantitative indices, such as tumor blood volume, are obtained using DEPWI, which allows correction of underestimation of tumor blood volume due to leakage of contrast agents from tumor vessels, in addition to simultaneous acquisition of tumor vessel permeability. This article describes basic concepts of DEPWI and demonstrates clinical applications in brain tumors.

  13. [Radial diagnosis MRT and MSCT in assessing the outcomes of surgical correction for complicated congenital heart defects: discordant atrioventricular connections with double outlet right ventricle].

    Science.gov (United States)

    Mershina, E A; Frolova, Iu V; Seliavko, Iu A; Sinitsyn, V E

    2012-01-01

    Discordant atrioventricular connection with double outlet right ventricle is a rare complicated congenital heart defect (CHD) requiring accurate diagnosis and appropriate correction. Magnetic resonance imaging (MRI) and multiple spiral computed tomography (MSCT) were used to assess long-term outcomes of the «classical» repair of the double outlet right ventricle in a patient presenting with discordant atrioventricular connection. Using a modified segmental approach provided all necessary anatomical evidence concerning the condition of the heart, major vessels, and an extracardiac pulmonary valve-containing conduit. MSCT made it possible to evaluate the degree of calcinosis and stenosis of the conduit and to visualize the coronary arteries. MRI was employed to assess the pressure gradient at the level of stenosis of the conduit, the relationship between the pulmonary and systemic circulation, transvalvular regurgitation, and ventricular contractility. Comprehensive use of present-day tomographic methods of imaging made it possible to obtain complete anatomical and functional information about the condition of the heart, vessels, extracardiac vascular transplant, as well as to reveal complications and determine the indications for a repeat operative intervention.

  14. Assessment of DNA double-strand breaks induced by intravascular iodinated contrast media following in vitro irradiation and in vivo, during paediatric cardiac catheterization.

    Science.gov (United States)

    Gould, Richard; McFadden, Sonyia L; Horn, Simon; Prise, Kevin M; Doyle, Philip; Hughes, Ciara M

    2016-01-01

    Paediatric cardiac catheterizations may result in the administration of substantial amounts of iodinated contrast media and ionizing radiation. The aim of this work was to investigate the effect of iodinated contrast media in combination with in vitro and in vivo X-ray radiation on lymphocyte DNA. Six concentrations of iodine (15, 17.5, 30, 35, 45, and 52.5 mg of iodine per mL blood) represented volumes of iodinated contrast media used in the clinical setting. Blood obtained from healthy volunteers was mixed with iodinated contrast media and exposed to radiation doses commonly used in paediatric cardiac catheterizations (0 mGy, 70 mGy, 140 mGy, 250 mGy and 450 mGy). Control samples contained no iodine. For in vivo experimentation, pre and post blood samples were collected from children undergoing cardiac catheterization, receiving iodine concentrations of up to 51 mg of iodine per mL blood and radiation doses of up to 400 mGy. Fluorescence microscopy was performed to assess γH2AX-foci induction, which corresponded to the number of DNA double-strand breaks. The presence of iodine in vitro resulted in significant increases of DNA double-strand breaks beyond that induced by radiation for ≥ 17.5 mg/mL iodine to blood. The in vivo effects of contrast media on children undergoing cardiac catheterization resulted in a 19% increase in DNA double-strand breaks in children receiving an average concentration of 19 mg/mL iodine to blood. A larger investigation is required to provide further information of the potential benefit of lowering the amount of iodinated contrast media received during X-ray radiation investigations. Copyright © 2015 John Wiley & Sons, Ltd.

  15. Double Swing

    DEFF Research Database (Denmark)

    Clausen, Lisbeth

    2017-01-01

    There are two main streams of understanding intercultural communication. The “classic” transmission models include the basic elements of communication involved in sending messages from a sender to a receiver. These models enable analysis of all communication elements and effects by focusing...... on sameness in communication. In contrast, Muneo Jay Yoshikawa's “double-swing” model of intercultural communication between the East and West is based on an eastern understanding of dialogue, collaborative communication, and co-creation of meaning. The double-swing model enables an understanding...... of communication as an ongoing encounter where both sender and receiver have mutual respect. It has four modes of communication: the ethnocentric, the dialectic, the control, and the dialogic. Both models have something to offer intercultural communication, but the double-swing model enables a worldview...

  16. Adaptation of the neutral bacterial comet assay to assess antimicrobial-mediated DNA double-strand breaks in Escherichia coli

    Science.gov (United States)

    SOLANKY, DIPESH; HAYDEL, SHELLEY E.

    2012-01-01

    This study aimed to determine the mechanism of action of a natural antibacterial clay mineral mixture, designated CB, by investigating the induction of DNA double-strand breaks (DSBs) in Escherichia coli. To quantify DNA damage upon exposure to soluble antimicrobial compounds, we modified a bacterial neutral comet assay, which primarily associates the general length of an electrophoresed chromosome, or comet, with the degree of DSB-associated DNA damage. To appropriately account for antimicrobial-mediated strand fragmentation, suitable control reactions consisting of exposures to water, ethanol, kanamycin, and bleomycin were developed and optimized for the assay. Bacterial exposure to the CB clay resulted in significantly longer comet lengths, compared to water and kanamycin exposures, suggesting that the induction of DNA DSBs contributes to the killing activity of this antibacterial clay mineral mixture. The comet assay protocol described herein provides a general technique for evaluating soluble antimicrobial-derived DNA damage and for comparing DNA fragmentation between experimental and control assays. PMID:22940101

  17. Carbon nanotube ecotoxicity in amphibians: assessment of multiwalled carbon nanotubes and comparison with double-walled carbon nanotubes.

    Science.gov (United States)

    Mouchet, Florence; Landois, Perine; Puech, Pascal; Pinelli, Eric; Flahaut, Emmanuel; Gauthier, Laury

    2010-08-01

    The potential impact of industrial multiwalled carbon nanotubes (MWNTs) was investigated under normalized laboratory conditions according to the International Standard micronucleus assay ISO 21427-1 for 12 days of half-static exposure to 0.1, 1, 10 and 50 mg/l of MWNTs in water. Three different end points were carried out for 12 days of exposure: mortality, growth inhibition and micronuclei induction in erythrocytes of the circulating blood of larvae. Raman spectroscopy analysis was used to study the presence of carbon nanotubes in the biological samples. Considering the high diversity of carbon nanotubes according to their different characteristics, MWNTs were analyzed in Xenopus larvae, comparatively to double-walled carbon nanotubes used in a previous study in similar conditions. Growth inhibition in larvae exposed to 50 mg/l of MWNTs was evidenced; however, no genetoxicity (micronucleus assay) was noticed, at any concentration. Carbon nanotube localization in the larvae leads to different possible hypothesis of mechanisms explaining toxicity in Xenopus.

  18. Assessment of the Economic and Environmental Impact of Double Glazed Façade Ventilation Systems in Mediterranean Climates

    Directory of Open Access Journals (Sweden)

    Pere Alavedra

    2013-09-01

    Full Text Available Free convection is the most often used method in order to reduce solar load gains on a building with double glazed façades (DGFs. However, depending on the climate factors, the thermal performance of a DGF may not be satisfactory and extra energy costs are required to obtain suitable comfort conditions inside the building. Forced ventilation systems are a feasible alternative to improve the thermal performance of a DGF in Mediterranean climates where large solar gains are a permanent condition throughout the year. In this paper the feasibility of using diverse forced ventilation methods in DGF is evaluated. In addition, an economical comparison between different mechanical ventilation systems was performed in order to demonstrate the viability of DGF forced ventilation. Moreover, an environmental study was carried out to prove the positive energetic balance on cooling loads between free and forced convection in DGF for Mediterranean climates. For this investigation, a CFD model was used to simulate the thermal conditions in a DGF for the different ventilation systems. Results obtained for heat flux, temperature and reductions in solar load gains were analyzed and applied for the economic and environmental research.

  19. Double pot and double compartment: integrating two approaches to study nutrient uptake by arbuscular mycorrhizal fungi

    NARCIS (Netherlands)

    Cardoso, I.M.; Boddington, C.L.; Janssen, B.H.; Oenema, O.; Kuyper, T.W.

    2004-01-01

    The double compartment technique has been commonly used in studies on nutrient uptake by mycorrhizas whereas the double pot technique has been used to assess the nutritional stress of plants grown in different soils. A combination of the double pot and the double compartment technique was used as a

  20. A randomized, double-blind, placebo-controlled study to assess QTc interval prolongation of standard dose aflibercept in cancer patients treated with docetaxel

    DEFF Research Database (Denmark)

    Maison-Blanche, Pierre; Vermorken, Jan B; Goksel, Tuncay

    2013-01-01

    : The effect of repeated doses of aflibercept on ventricular repolarization in cancer patients was evaluated in an intensive electrocardiogram trial. This randomized, placebo-controlled, double-blind trial was conducted in 87 treated solid tumor patients. Treatment was with 6 mg/kg aflibercept, 1...... were assessed at similar time points. Eighty-four patients (43 placebo and 41 aflibercept) were evaluable for QT interval, Fridericia correction (QTcF) at cycle 1 and 59 (31 placebo and 28 aflibercept) at cycle 3. During cycle 3, from 30 minutes to 6 hours after the start of aflibercept, the maximum...... observed upper limit of the QTcF 90% confidence interval was 16 ms, for a mean of 8.4 ms. QTcF prolongation above 480 ms and 60 ms above baseline was observed in 1 aflibercept patient (2%). The slope of the relationship between free aflibercept concentration and QTcF was 0.048 (95% confidence interval, 0...

  1. Assessing the prospects for achieving double-shell ignition on the National Ignition Facility using vacuum hohlraums

    Energy Technology Data Exchange (ETDEWEB)

    Amendt, P; Cerjan, C; Hamza, A; Hinkel, D; Milovich, J L; Robey, H F

    2006-10-26

    The goal of demonstrating ignition on the National Ignition Facility (NIF) has motivated a revisit of double-shell (DS) targets as a complementary path to the cryogenic baseline approach. Expected benefits of DS ignition targets include non-cryogenic deuterium-tritium (DT) fuel preparation, minimal hohlraum-plasma mediated laser backscatter, low threshold ignition temperatures ({approx} 4 keV) for relaxed hohlraum x-ray flux asymmetry tolerances, and minimal (two-) shock timing requirements. On the other hand, DS ignition presents several formidable challenges, encompassing room-temperature containment of high-pressure DT ({approx} 790 atm) in the inner shell, strict concentricity requirements on the two shells (< 3 {micro}m), development of nano-porous (<100 nm) low-density (<100 mg/cc) metallic foams for structural support of the inner shell and hydrodynamic instability mitigation, and effective control of hydrodynamic instabilities on the high-Atwood number interface between the DT fuel and the high-Z inner shell. Recent progress in DS ignition designs and required materials-science advances at the nanoscale are described herein. Two new ignition designs that use rugby-shaped vacuum hohlraums are presented which utilize either 1 MJ or 2 MJ of laser energy at 3{omega}. The capability of the NIF to generate the requested reverse-ramp pulse shape for DS ignition is expected to be comparable to the planned high-contrast ({approx}100) pulse-shape at 1.8 MJ for the baseline cryogenic target. Nano-crystalline, high-strength, Au-Cu alloy inner shells are under development using electrochemical deposition over a glass mandrel, exhibiting tensile strengths well in excess of 790 atm. Novel, low-density (85 mg/cc) copper foams have recently been demonstrated using 10 mg/cc SiO{sub 2} nano-porous aerogels with suspended Cu particles. A prototype demonstration of an ignition DS is planned for 2008, incorporating the needed novel nano-materials science developments and the

  2. Double screening

    Energy Technology Data Exchange (ETDEWEB)

    Gratia, Pierre [Department of Physics, University of Chicago,South Ellis Avenue, Chicago, IL 60637 (United States); Hu, Wayne [Department of Astronomy and Astrophysics, University of Chicago,South Ellis Avenue, Chicago, IL 60637 (United States); Enrico Fermi Institute and Kavli Institute for Cosmological Physics, University of Chicago,South Ellis Avenue, Chicago, IL 60637 (United States); Joyce, Austin [Enrico Fermi Institute and Kavli Institute for Cosmological Physics, University of Chicago,South Ellis Avenue, Chicago, IL 60637 (United States); Ribeiro, Raquel H. [School of Physics and Astronomy, Queen Mary University of London,Mile End Road, London, E1 4NS (United Kingdom)

    2016-06-15

    Attempts to modify gravity in the infrared typically require a screening mechanism to ensure consistency with local tests of gravity. These screening mechanisms fit into three broad classes; we investigate theories which are capable of exhibiting more than one type of screening. Specifically, we focus on a simple model which exhibits both Vainshtein and kinetic screening. We point out that due to the two characteristic length scales in the problem, the type of screening that dominates depends on the mass of the sourcing object, allowing for different phenomenology at different scales. We consider embedding this double screening phenomenology in a broader cosmological scenario and show that the simplest examples that exhibit double screening are radiatively stable.

  3. A double-blind, randomized study to assess the effectiveness of different moisturizers in preventing dermatitis induced by hand washing to simulate healthcare use.

    Science.gov (United States)

    Williams, C; Wilkinson, S M; McShane, P; Lewis, J; Pennington, D; Pierce, S; Fernandez, C

    2010-05-01

    Healthcare-associated infection is an important worldwide problem that could be reduced by better hand hygiene practice. However, irritant contact dermatitis of the hands as a result of repeated hand washing is a potential complication that may be preventable by the regular use of an emollient. To assess the effect of moisturizer application after repeated hand washing (15 times daily) vs. soap alone. In a double-blind, randomized study, the effect of five different moisturizers on skin barrier function was determined by assessment after repeated hand washing over a 2-week period in healthy adult volunteers. Assessments of transepidermal water loss (TEWL), epidermal hydration and a visual assessment using the Hand Eczema Severity Index (HECSI) were made at days 0, 7 and 14. In total, 132 patients were enrolled into the study. A statistically significant worsening of the clinical condition of the skin as measured by HECSI was seen from baseline to day 14 (P = 0.003) in those subjects repeatedly washing their hands with soap without subsequent application of moisturizer. No change was seen in the groups using moisturizer. Subclinical assessment of epidermal hydration as a measure of skin barrier function showed significant increases from baseline to day 14 after the use of three of the five moisturizing products (P = 0.041, 0.001 and 0.009). Three of the five moisturizers tested led to a statistically significant decrease in TEWL at day 7 of repeated hand washing. This effect was sustained for one moisturizing product at day 14 of hand washing (P = 0.044). These results support the view that the regular application of moisturizers to normal skin offers a protective effect against repeated exposure to irritants, with no evidence of a reduction in barrier efficiency allowing the easier permeation of irritant substances into the skin as has been suggested by other studies. Regular use of emollient in the healthcare environment may prevent the development of dermatitis.

  4. A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women.

    Science.gov (United States)

    Birnbaum, Jay E; McDaniel, David H; Hickman, Janet; Dispensa, Lisa; Le Moigne, Anne; Buchner, Larry

    2017-03-01

    Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance. Evaluate a multicomponent nutritional supplement on photoaged skin. This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatrick skin types I-IV and Glogau classification types II-III to a multicomponent nutritional supplement or placebo for 24 weeks. The primary endpoint was Investigator Global Assessment of overall facial appearance at week 24. Secondary endpoints included investigator- and subject-rated assessments of the face, décolletage, and hands; facial photography assessments (conducted by an independent panel of dermatologists); and instrumental measures. Analysis of variance was used to assess between-group differences (P ≤ 0.05). Of 194 randomized subjects, 171 completed the study. Subjects had a mean age of 53 years and were primarily white (81%), had Glogau II (58%) and Fitzpatrick III (45%; significantly more supplement subjects had Fitzpatrick III [54%] vs. placebo [35%]; P = 0.039). At week 24, Investigator Global Assessment of overall facial appearance was numerically but not statistically better for supplement over placebo (mean difference: 0.14 [95% confidence interval: -0.16-0.44]; P = 0.358). A significant treatment-by-site interaction (P = 0.073) was observed; by-site analyses revealed a significant difference at one of three geographical sites for supplement vs. placebo (P = 0.001). Differences on secondary endpoints were generally not significant. In the first multicenter study conducted with this multicomponent nutritional supplement, no significantly greater effects vs. placebo were observed on the primary endpoint, perhaps because of significant between-site variability. © 2016 The Authors. Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc.

  5. 3D double-echo steady-state sequence assessment of hip joint cartilage and labrum at 3 Tesla: comparative analysis of magnetic resonance imaging and intraoperative data

    Energy Technology Data Exchange (ETDEWEB)

    Schleich, Christoph; Antoch, Gerald [University of Dusseldorf, Department of Diagnostic and Interventional Radiology, Medical Faculty, Duesseldorf (Germany); Hesper, Tobias; Rettegi, Fanni; Zilkens, Christoph; Krauspe, Ruediger; Bittersohl, Bernd [University of Dusseldorf, Department of Orthopedic Surgery, Medical Faculty, Duesseldorf (Germany); Hosalkar, Harish S. [Paradise Valley Hospital, Joint Preservation and Deformity Correction, San Diego, CA (United States); Tri-city Medical Center, Hip Preservation, San Diego, CA (United States)

    2017-10-15

    To assess the diagnostic accuracy of a high-resolution, three-dimensional (3D) double-echo steady-state (DESS) sequence with radial imaging at 3 Tesla (T) for evaluating cartilage and labral alterations in the hip. Magnetic resonance imaging (MRI) data obtained at 3 T, including radially reformatted DESS images and intraoperative data of 45 patients (mean age 42 ± 13.7 years) who underwent hip arthroscopy, were compared. The acetabular cartilage and labrum of the upper hemisphere of the acetabulum and the central femoral head cartilage were evaluated. Sensitivity, specificity, accuracy, and negative and positive predictive values were determined. Sensitivity, specificity and accuracy of the DESS technique were 96.7%, 75% and 93.7% for detecting cartilage lesions and 98%, 76.2% and 95.9% for detecting labral lesions. The positive and negative predictive values for detecting or ruling out cartilage lesions were 96% and 78.9%. For labral lesions, the positive and negative predictive values were 97.5% and 80%. A high-resolution, 3D DESS technique with radial imaging at 3 T demonstrated high accuracy for detecting hip cartilage and labral lesions with excellent interobserver agreement and moderate correlation between MRI and intraoperative assessment. (orig.)

  6. A randomized, double-blind, placebo-controlled study assessing the safety and tolerability of regadenoson in subjects with asthma or chronic obstructive pulmonary disease.

    Science.gov (United States)

    Prenner, Bruce M; Bukofzer, Stan; Behm, Sarah; Feaheny, Kathleen; McNutt, Bruce E

    2012-08-01

    Adenosine receptor stress agents for myocardial perfusion imaging (MPI) may cause A(2B) and/or A(3) receptor-mediated bronchoconstriction, of particular concern to physicians testing patients with asthma or chronic obstructive pulmonary disease (COPD). A Phase 4, randomized, double-blind study (NCT00862641) assessed the safety of the selective A(2A) receptor agonist, regadenoson, compared with placebo in subjects with asthma or COPD who represented likely candidates for MPI. Overall, 356 and 176 subjects with asthma and 316 and 151 subjects with COPD received regadenoson and placebo, respectively. The percentage of subjects experiencing a >15% decrease in FEV(1) from baseline to any assessment up to 24 hours post-baseline was not statistically significantly different between the regadenoson and the placebo groups in the asthma or COPD stratum. Dyspnea, the most frequent respiratory adverse event, occurred with higher incidence (P regadenoson group than the placebo group in the asthma (10.7% vs 1.1%) and COPD (18.0% vs 2.6%) strata. No subjects experienced severe bronchoconstriction, although the occurrence of such reactions with adenosine receptor agonists cannot be ruled out, such that caution is advised. This information may be helpful to physicians selecting a pharmacologic stress agent for MPI in patients with asthma or COPD.

  7. Energy Performance Assessment of a 2nd-Generation Vacuum Double Glazing Depending on Vacuum Layer Position and Building Type in South Korea

    OpenAIRE

    Seung-Chul Kim; Jong-Ho Yoon; Ru-Da Lee

    2017-01-01

    (1) Background: The application of high insulation to a building envelope helps reduce the heating load, but increases the cooling load. Evaluating the installation of high insulation glazing to buildings in climate zones with four distinct seasons, as in the case of South Korea, is very important; (2) Methods: This study compared the heating energy performance of four types of glazing, inside vacuum double glazing, outside vacuum double glazing, single vacuum glazing, and low-e double glazin...

  8. Otimização das superfícies dos implantes: plasma de titânio e jateamento com areia condicionado por ácido - estado atual Optimization of implant surfaces: titanium plasma spray and acid-etched sandblasting - current state

    Directory of Open Access Journals (Sweden)

    Evandro Scigliano AMARANTE

    2001-06-01

    Full Text Available O objetivo deste trabalho foi analisar os resultados da literatura publicada sobre superfícies de implantes tratadas com plasma de titânio (TPS e jateadas com areia e tratadas com ácido (SLA. Isoladamente, a textura da superfície foi a característica mais marcante na promoção da osseointegração. Os estudos da topografia da superfície implantar no comportamento celular mostraram que o osso se deposita indistintamente em superfícies porosas ou lisas, seja em implantes de cerâmica, titânio, ou em ampla variedade de outras superfícies. A porosidade portanto, não é condição necessária para que ocorra aposição óssea, entretanto, desempenha um papel preponderante no percentual de aposição óssea sobre a superfície do implante, assim como na velocidade com que essa deposição ocorre. Nesta revisão destacou-se uma promissora superfície denominada SLA, tratada com jatos de areia (partículas pequenas seguida de ataque ácido. Os resultados demonstraram que tanto a rugosidade como o tratamento químico das superfícies podem influenciar bastante a força superficial de cisalhamento (resistência oferecida à remoção. Estas características da superfície do titânio, além de otimizar o procedimento, podem ainda, por exemplo, permitir a colocação dos implantes em função mais precocemente e ampliar a gama de aplicações possíveis para osso alveolar de densidade inferior, ou favorecer sua aplicação em osso regenerado.The aim of this review was to update the concepts regarding the preparation of the surfaces of titanium implants, focusing on TPS (titanium plasma-sprayed implants and SLA (sandblasted and acid etched implants. Texture was the most remarkable isolated feature, regarded as an osseointegration promoter. In a comprehensive review of the effects of implant surface topography on cell behavior, one can verify that there is bone apposition onto the implant surface regardless of its characteristics: polished or

  9. Assessing the benefit of accepting a single lung offer now compared with waiting for a subsequent double lung offer.

    Science.gov (United States)

    Wang, Qing; Rogers, Chris A; Bonser, Robert S; Banner, Nicholas R; Demiris, Nikolaos; Sharples, Linda D

    2011-04-27

    Comparisons of survival after single lung transplant (SLT) and bilateral lung transplant (BLT) are useful in making policy decisions, but a more relevant comparison for an individual patient is between accepting a single lung when offered and remaining on the waiting list with the potential to subsequently receive a suitable pair of lungs. U.K. data from a cohort of 1211 adult, first lung transplant candidates diagnosed with pulmonary fibrosis (PF) or chronic obstructive pulmonary disease (COPD), listed July 1995 to July 2006 and followed up till December 2007, were analyzed. A sequentially stratified proportional hazards model was used to assess mortality after SLT relative to continued waiting for BLT. For patients with PF, SLT was associated with a significant reduction in hazard relative to waiting for BLT (hazard ratio 0.81, 95% confidence interval 0.68-0.97, P=0.021), particularly for older patients with body mass index less than 20 and forced expired volume in 1 sec is less than 1 L. In contrast, our results gave no support for accepting SLT rather than waiting for BLT for patients with COPD (hazard ratio 1.08, 95% confidence interval 0.92-1.29, P=0.35). The high pretransplant risk of death for patients with PF, particularly older patients with low body mass index and poor lung function, suggests that they would benefit from taking an SLT if offered. However, there is no benefit of accepting SLT rather than waiting for BLT for patients with COPD; this reflects the low relative hazard in the absence of transplant for these patients. © 2011 by Lippincott Williams & Wilkins

  10. A prospective split-face double-blind randomized placebo-controlled trial to assess the efficacy of methyl aminolevulinate + red-light in patients with facial photodamage.

    Science.gov (United States)

    Sanclemente, G; Medina, L; Villa, J-F; Barrera, L-M; Garcia, H-I

    2011-01-01

    To date, there is no gold standard therapy for skin photoageing. In the last decade, laser technologies have offered great promise among skin-rejuvenation therapies; however, both non-ablative and ablative fractional resurfacing modalities have their own benefits and drawbacks. More recently, open-label studies and few controlled trials have suggested that photodynamic therapy may have therapeutic potential in photodamage. To assess the efficacy of methyl aminolevulinate + red-light on facial photodamage in a double-blind split-face randomized placebo-controlled trial. Subjects had initially two split-face treatments 2-3 weeks apart in which half of the face was treated with MAL + red-light compared with placebo + red-light. Primary outcome was the assessment of global photodamage 1 month after session 2. Secondary outcomes included the assessment of fine lines, mottled pigmentation, tactile roughness, sallowness, erythema and telangiectasia 1 month after session 2, according to severity scores rated as failure, improvement or success. Based on the intention-to-treat analysis, a total of 48 patients (96 split-faces) were included. Facial global photodamage success or improvement had occurred in 94 split-faces and in no split-faces receiving placebo (RR: 0.02; 95% confidence interval, 0.0-0.14; P = 0.0000). One patient had an adverse event that led to the discontinuation of the therapy after session 1. Methyl aminolevulinate + red-light demonstrated significantly superior efficacy in global facial photodamage compared with placebo. This therapy was also useful for all other specific secondary outcomes, except for telangiectasia. Overall, MAL + red-light sessions were well tolerated and resulted in high/total patient satisfaction in the majority of subjects (80.4%). © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.

  11. Assessment of Double Outlet Right Ventricle Associated with Multiple Malformations in Pediatric Patients Using Retrospective ECG-Gated Dual-Source Computed Tomography.

    Directory of Open Access Journals (Sweden)

    Ke Shi

    Full Text Available To evaluate the feasibility and diagnostic accuracy of retrospective electrocardiographically (ECG-gated dual-source computed tomography (DSCT for the assessment of double outlet right ventricle (DORV and associated multiple malformations in pediatric patients.Forty-seven patients <10 years of age with DORV underwent retrospective ECG-gated DSCT. The location of the ventricular septal defect (VSD, alignment of the two great arteries, and associated malformations were assessed. The feasibility of retrospective ECG-gated DSCT in pediatric patients was assessed, the image quality of DSCT and the agreement of the diagnosis of associated malformations between DSCT and transthoracic echocardiography (TTE were evaluated, the diagnostic accuracies of DSCT and TTE were referred to surgical results, and the effective doses were calculated.Apart from DORV, 109 associated malformations were confirmed postoperatively. There was excellent agreement (κ = 0.90 for the diagnosis of associated malformations between DSCT and TTE. However, DSCT was superior to TTE in demonstrating paracardiac anomalies (sensitivity, coronary artery anomalies: 100% vs. 80.00%, anomalies of great vessels: 100% vs. 88.57%, separate thoracic and abdominal anomalies: 100% vs. 76.92%, respectively. Combined with TTE, DSCT can achieve excellent diagnostic performance in intracardiac anomalies (sensitivity, 91.30% vs. 100%. The mean image quality score was 3.70 ± 0.46 (κ = 0.76. The estimated mean effective dose was < 1 mSv (0.88 ± 0.34 mSv.Retrospective ECG-gated DSCT is a better diagnostic tool than TTE for pediatric patients with complex congenital heart disease such as DORV. Combined with TTE, it may reduce or even obviate the use of invasive cardiac catheterization, and thus expose the patients to a much lower radiation dose.

  12. Assessing the therapeutic use of Lafoensia pacari St. Hil. extract (mangava-brava) in the eradication of Helicobacter pylori: double-blind randomized clinical trial.

    Science.gov (United States)

    da Mota Menezes, Valfredo; Atallah, Alvaro Nagib; Lapa, Antonio José; Catapani, Wilson R

    2006-06-01

    The eradication of Helicobacter pylori is easily achieved by combining antisecretory agents and antibiotics; however, the cost of these associations is very high for the population of Third World countries, where the prevalence of the infection is even higher and leads to markedly reduced treatment effectiveness. We tested a plant (Lafoensia pacari) that is used in the central region of Brazil. According to previous studies, this plant has high concentrations of ellagic acid, which presents gastric antisecretory and antibacterial actions. One hundred dyspeptic, urease-positive patients were randomized to receive 500 mg of methanolic extract of L. pacari (n = 55) or placebo (n = 45), for 14 days, in a double-blind clinical trial. The main variables assessed were the eradication of H. pylori 8 weeks after the intervention and complete symptom relief at the end of the treatment. The examinations (urease and histology) showed persistence of H. pylori in 100% of participants. Complete symptom relief was experienced by 42.5% of patients (95% CI: 29.4-55.8) in the intervention group and by 21% (95% CI: 8.8-33.1) in the control group, p = .020. The side-effects were minimal and similar in both groups. The extract of L. pacari as a single agent was not effective to eradicate H. pylori. However, it was well tolerated and many participants reported relief of symptoms. Future studies may test the agent using larger doses and longer periods, in monotherapy or in combination with antibiotics.

  13. A double-blind randomized controlled clinical trial to assess the effect of Doppler optimized intraoperative fluid management on outcome following radical cystectomy.

    Science.gov (United States)

    Pillai, Praveen; McEleavy, Irene; Gaughan, Matthew; Snowden, Christopher; Nesbitt, Ian; Durkan, Garrett; Johnson, Mark; Cosgrove, Joseph; Thorpe, Andrew

    2011-12-01

    Cardiovascular optimization via esophageal Doppler can minimize gastrointestinal hypoperfusion, reducing the risk of multiple organ dysfunction and postoperative complications during major surgery. We assessed the effect of esophageal Doppler guided cardiovascular optimization in patients undergoing radical cystectomy. We conducted a prospective, randomized, double-blind controlled trial at a United Kingdom teaching hospital between 2006 and 2009. A total of 66 patients were randomized to a control arm (34) and an intervention arm (32). The control group received standard intraoperative fluids. The intervention group received (additional) Doppler guided fluid. Primary outcomes were markers of gastrointestinal morbidity such as ileus, flatus and bowel opening. Secondary outcomes were postoperative nausea and vomiting, wound infection and operative intravenous fluid volumes (total and hourly). There were significant reductions in the control and intervention arms in the incidence of ileus (18 vs 7, p Doppler significantly improved postoperative markers of gastrointestinal function. Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  14. A Randomized, Double-Blind Study Assessing Changes in Cognitive Function in Indian School Children Receiving a Combination of Bacopa monnieri and Micronutrient Supplementation vs. Placebo

    Directory of Open Access Journals (Sweden)

    Tora Mitra-Ganguli

    2017-11-01

    Full Text Available Several studies have indicated a chronic cognitive enhancing effect of Bacopa monnieri across different ages and cognitive impairment associated with vitamin and mineral deficiencies in children. Therefore, we investigated the effects of 4-month supplementation with a combination of B. monnieri extract and multiple micronutrients on cognitive functions in Indian school children aged 7–12 years. This was a randomized, double-blind, parallel design, single-center study in which 300 children were randomized to receive a beverage either fortified with B. monnieri and multiple micronutrients (“fortified” or a non-fortified isocaloric equivalent (“control” twice-daily for 4 months. Cognitive function was assessed by the Cambridge Neuropsychological Automated Test Battery (CANTAB administered at baseline, Day 60 and Day 121. The primary endpoint was change in short-term memory (working memory from baseline in subjects receiving “fortified” vs. “control” beverages after 4 months. Secondary endpoints included sustained attention, episodic memory, and executive function. The “fortified” beverage did not significantly improve short-term memory or any of the secondary outcomes tested relative to the “control” beverage. However, the spatial working memory “strategy” score showed significant improvement on Day 60 (difference between groups in change from baseline: −0.55; p < 0.05, but not on Day 121 due to the active intervention. Study products were well-tolerated. Reasons for these unexpected findings are discussed.

  15. Assessment of the antidandruff activity of a new shampoo: a randomized, double-blind, controlled study by clinical and instrumental evaluations.

    Science.gov (United States)

    Sparavigna, Adele; Setaro, Michele; Caserini, Maurizio; Bulgheroni, Anna

    2013-01-01

    The aim of this randomized, double-blind, controlled study was to evaluate the antidandruff activity exerted by a new shampoo on patients affected by dandruff and/or mild seborrheic dermatitis by means of both D-squame technique coupled with image analysis and clinical assessments. Thirty-four patients were enrolled and 1:1 randomly assigned to either a test shampoo or a comparative shampoo group. Treatment schedule was twice a week for 4 weeks. The D-squame technique was shown to be able to objectively record variations in scalp desquamation both between test and comparative groups and within the same group over time. The results obtained with this instrumental approach showed a statistically significant reduction by 52% vs baseline after 2 weeks of treatment. There was an even greater reduction after 4 weeks (-66%). This reduction was statistically significant compared with the comparative group at the same time points. The analysis of all the other parameters (except Wood's lamp) confirmed the superiority of the test vs the comparative shampoo. The test shampoo proved to be safe, well tolerated, and accepted by the patients for cosmetic acceptability and efficacy. The study confirmed the antidandruff efficacy of the test shampoo and its superiority vs the comparative shampoo.

  16. The impact of topical lidocaine on pain level assessment during and after vacuum-assisted closure dressing changes: a double-blind, prospective, randomized study.

    Science.gov (United States)

    Franczyk, Mieczyslawa; Lohman, Robert F; Agarwal, Jayant P; Rupani, Gita; Drum, Melinda; Gottlieb, Lawrence J

    2009-09-01

    Vacuum-assisted closure dressing changes are frequently painful. The authors hypothesized that administering topical lidocaine into the vacuum-assisted closure sponge would decrease pain during dressing changes. A double-blind, randomized, prospective study was performed on patients (n = 70) undergoing vacuum-assisted closure dressing changes at a single institution between October of 2003 and June of 2005. Patients were randomized to receive either 0.2% lidocaine or 0.9% saline administered through the vacuum-assisted closure tubing into the foam dressing 30 minutes before changing the dressing. All patients received morphine sulfate ad libitum. Pain scores were assessed according to a 0 to 10 numeric pain scale. Wound characteristics and patient demographics were similar for both groups. Patients receiving lidocaine reported less pain than control patients during the dressing change (4.3 versus 6.3; p = 0.005) and immediately after (2.4 versus 4.7; p 3 mg morphine equivalent) than in the control group. During the initial vacuum-assisted closure dressing change, 0.2% lidocaine administered through the suction tubing led to a reduction in pain reported by the patients in the authors' study. The duration of lidocaine administered in this fashion may be fairly short, because more patients in this group began to request small doses of opiates 30 minutes after the dressing change. Thus, lidocaine may improve patient comfort during vacuum-assisted closure therapy.

  17. Energy Performance Assessment of a 2nd-Generation Vacuum Double Glazing Depending on Vacuum Layer Position and Building Type in South Korea

    Directory of Open Access Journals (Sweden)

    Seung-Chul Kim

    2017-08-01

    Full Text Available (1 Background: The application of high insulation to a building envelope helps reduce the heating load, but increases the cooling load. Evaluating the installation of high insulation glazing to buildings in climate zones with four distinct seasons, as in the case of South Korea, is very important; (2 Methods: This study compared the heating energy performance of four types of glazing, inside vacuum double glazing, outside vacuum double glazing, single vacuum glazing, and low-e double glazing, with fixed low-e coating positions on the inside of the room in a mock-up chamber under the same conditions. The annual energy consumption according to the building type was analyzed using a simulation; (3 Results: As the insulation performance of building envelopes has increased, the energy saving rate of inside vacuum double glazing has been increased further in office buildings. In residential buildings, the energy saving rate of inside vacuum double glazing with a low SHGC (solar heat gain coefficient has become higher than that of outside vacuum double glazing; (4 Conclusions: Since the effects of SHGC on the energy saving rates are greater in high insulation buildings, SHGC should be considered carefully when selecting glazing in climate zones with distinct winter and summer seasons.

  18. A randomised, double blind, placebo-controlled, multi-centric parallel arm trial to assess the effects of homoeopathic medicines on chronic rhinosinusitis

    Directory of Open Access Journals (Sweden)

    Raj K Manchanda

    2014-01-01

    Full Text Available Background: Chronic rhinosinusitis (CRS is one of the most common illnesses interfering with patient′s quality of life and work. Observational studies conducted by the Council indicate positive outcome. This protocol has been developed to ascertain the usefulness of homoeopathic intervention in comparison with control group in a randomised control setting. Objectives: Primary objective is to evaluate the changes in TSS (Total Symptoms Score and SNOT-22 (Sino-nasal Outcome Test-22 within the two groups of the study (Homoeopathy + Placebo. Secondary objective is to evaluate changes in SNOT-22 at end of the trial, changes in Lund and Mackay staging of CT scan, rhinoscopy grading, absolute eosinophil count, global assessment by investigator and patient, and number of acute exacerbations of CRS (for frequency, duration and intensity as per TSS scale compared to placebo. Methods/Design: This is a randomised double blind, placebo-controlled, multi-centric parallel arm trial of 6 months (three months treatment and three months observation period with 14 days run-in period. The primary outcome is a composite of the changes in the TSS and SNOT-22 over 3 months from baseline with area under the curve and changes over 3 months in the Sinus Nasal Outcome Test 22 (SNOT-22 from baseline. Prescription shall be made as per the homoeopathic principles. Efficacy data will be analysed in the intention-to-treat population. Discussion: This trial will help to evaluate the efficacy of homoeopathic individualised treatment using LM-potencies versus placebo in patients suffering from CRS as per the homoeopathic dictum.

  19. Assessment of direct analgesic effect of duloxetine for chronic low back pain: post hoc path analysis of double-blind, placebo-controlled studies.

    Science.gov (United States)

    Enomoto, Hiroyuki; Fujikoshi, Shinji; Funai, Jumpei; Sasaki, Nao; Ossipov, Michael H; Tsuji, Toshinaga; Alev, Levent; Ushida, Takahiro

    2017-01-01

    Comorbid depression and depressive symptoms are common in patients with chronic low back pain (CLBP). Duloxetine is clinically effective in major depressive disorder and several chronic pain states, including CLBP. The objective of this post hoc meta-analysis was to assess direct and indirect analgesic efficacy of duloxetine for patients with CLBP in previous clinical trials. Post hoc path analyses were conducted of 3 randomized, double-blind, clinical studies of patients receiving duloxetine or placebo for CLBP. The primary outcome measure for pain was the Brief Pain Inventory, average pain score. A secondary outcome measure, the Beck Depression Inventory-II, was used for depressive symptoms. The changes in score from baseline to endpoint were determined for each index. Path analyses were employed to calculate the proportion of analgesia that may be attributed to a direct effect of duloxetine on pain. A total of 851 patients (400 duloxetine and 451 placebo) were included in this analysis. Duloxetine significantly improved pain scores compared with placebo (p<0.001). It also significantly improved depressive scores compared with placebo (p=0.015). Path analyses showed that 91.1% of the analgesic effect of duloxetine could be attributed to a direct analgesic effect, and 8.9% to its antidepressant effect. Similar results were obtained when data were evaluated at weeks 4 and 7, and when patients were randomized to subgroups based on baseline pain scores, baseline depressive symptoms scores, and gender. Duloxetine significantly improved pain in patients with CLBP. Path analyses results suggest that duloxetine produced analgesia mainly through mechanisms directly impacting pain modulation rather than lifting depressive symptoms. This effect was consistent across all subgroups tested.

  20. Double inflation

    Energy Technology Data Exchange (ETDEWEB)

    Silk, J.; Turner, M.S.

    1986-04-01

    The Zel'dovich spectrum of adiabatic density perturbations is a generic prediction of inflation. There is increasing evidence that when the spectrum is normalized by observational data on small scales, there is not enough power on large scales to account for the observed large-scale structure in the Universe. Decoupling the spectrum on large and small scales could solve this problem. As a means of decoupling the large and small scales we propose double inflation (i.e., two episodes of inflation). In this scenario the spectrum on large scales is determined by the first episode of inflation and those on small scales by a second episode of inflation. We present three models for such a scenario. By nearly saturating the large angular-scale cosmic microwave anisotropy bound, we can easily account for the observed large-scale structure. We take the perturbations on small scales to be very large, deltarho/rho approx. = 0.1 to 0.01, which results in the production of primordial black holes (PBHs), early formation of structure, reionization of the Universe, and a rich array of astrophysical events. The ..cap omega..-problem is also addressed by our scenario. Allowing the density perturbations produced by the second episode of inflation to be large also lessens the fine-tuning required in the scalar potential and makes reheating much easier. We briefly speculate on the possibility that the second episode of inflation proceeds through the nucleation of bubbles, which today manifest themselves as empty bubbles whose surfaces are covered with galaxies. 37 refs., 1 fig.

  1. Seeing Double

    Science.gov (United States)

    Pesic, Peter

    2003-10-01

    The separateness and connection of individuals is perhaps the central question of human life: What, exactly, is my individuality? To what degree is it unique? To what degree can it be shared, and how? To the many philosophical and literary speculations about these topics over time, modern science has added the curious twist of quantum theory, which requires that the elementary particles of which everything consists have no individuality at all. All aspects of chemistry depend on this lack of individuality, as do many branches of physics. From where, then, does our individuality come? In Seeing Double, Peter Pesic invites readers to explore this intriguing set of questions. He draws on literary and historical examples that open the mind (from Homer to Martin Guerre to Kafka), philosophical analyses that have helped to make our thinking and speech more precise, and scientific work that has enabled us to characterize the phenomena of nature. Though he does not try to be all-inclusive, Pesic presents a broad range of ideas, building toward a specific point of view: that the crux of modern quantum theory is its clash with our ordinary concept of individuality. This represents a departure from the usual understanding of quantum theory. Pesic argues that what is bizarre about quantum theory becomes more intelligible as we reconsider what we mean by individuality and identity in ordinary experience. In turn, quantum identity opens a new perspective on us. Peter Pesic is a Tutor and Musician-in-Residence at St. John's College, Santa Fe, New Mexico. He has a Ph.D. in physics from Stanford University.

  2. The concept of double inlet-double outlet right ventricle: a distinct congenital heart disease

    OpenAIRE

    Spadotto, V; Frescura, C; Ho, SY; Thiene, G

    2016-01-01

    The aim of this study was to estimate the incidence and to analyze the anatomy of double inlet-double outlet right ventricle complex and its associated cardiac anomalies in our autopsy series. Among the 1640 hearts with congenital heart disease of our Anatomical Collection, we reviewed the specimens with double inlet-double outlet right ventricle, according to the sequential-segmental analysis, identifying associated cardiac anomalies and examining lung histology to assess the presence of pul...

  3. [Treating pain after dental surgery: a randomised, controlled, double-blind trial to assess a new formulation of paracetamol, opium powder and caffeine versus tramadol or placebo].

    Science.gov (United States)

    Borel, Jean-François; Deschaumes, Christophe; Devoize, Laurent; Huard, Cédric; Orliaguet, Thierry; Dubray, Claude; Baudet-Pommel, Martine; Dallel, Radhouane

    2010-05-01

    The aim of this study was to evaluate the analgesic efficacy and the safety of the association, paracetamol, opium prepared and caffeine, in two different dosages as compared to the conventional analgesic tramadol hydrochloride, on acute postoperative dental pain. We conducted a randomised, double-blind, multicentre, parallel-group clinical trial to test the efficacy and safety of single doses of two associations; paracetamol 500 mg, caffeine 50mg, opium prepared 25, and paracetamol 500 mg, caffeine 50mg, opium prepared 50mg, as compared to tramadol hydrochloride 100mg (called hereafter tramadol 100), and placebo, in the control of postoperative pain following the removal of 2 ipsilateral impacted third molars. The primary efficacy criterion was the sum of pain intensity differences as assessed every 30 minutes within 3 hours after the baseline assessment and administration of study treatment (SPID(0-3h)). Of the 232 randomised patients, 228 (98%) completed the study. Analysis of the primary efficacy criterion (SPID(0-3h)) established: (i) the superiority of the 3 active study treatments vs. placebo (p<0.005); (ii) non-inferiority of paracetamol, caffeine, and opium 25mg, and paracetamol, caffeine, and opium 50mg vs. tramadol. Besides, both formulations of paracetamol, caffeine, and opium showed: (i) a faster onset of analgesic effect as compared to tramadol 100; (ii) a significantly stronger analgesic efficacy than tramadol 100, as measured 1 hour after the treatment intake; this superiority lasted all over the study duration for paracetamol, caffeine, and opium 50mg but not for paracetamol, caffeine, and opium 25mg. No unexpected safety concerns occurred, the two formulations of paracetamol, caffeine, and opium showed a good safety profile especially with paracetamol, caffeine, and opium 25mg as compared to tramadol. This study evidenced the non-inferiority of the paracetamol, caffeine, and opium 25mg or 50mg vs. tramadol 100, and even though the strengths of the

  4. Double hard scattering without double counting

    Science.gov (United States)

    Diehl, Markus; Gaunt, Jonathan R.; Schönwald, Kay

    2017-06-01

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  5. Double hard scattering without double counting

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Gaunt, Jonathan R. [VU Univ. Amsterdam (Netherlands). NIKHEF Theory Group; Schoenwald, Kay [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2017-02-15

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  6. Synthesis and In Vitro Characterization of Fe3+-Doped Layered Double Hydroxide Nanorings as a Potential Imageable Drug Delivery System

    Directory of Open Access Journals (Sweden)

    Lijun Wang

    2017-09-01

    Full Text Available Highly dispersed Fe3+-doped layered double hydroxide (LDH-Fe nanorings were obtained by a simple coprecipitation-acid etching approach. The morphology, structure, magnetic resonance imaging (MRI performance in vitro, drug loading and releasing, Fe3+ leakage, and cytotoxicity of the as-prepared LDH-Fe nanorings were characterized. The LDH-Fe nanorings showed good water dispersity and a well-crystallized structure. The DLS average size of nanoparticles was measured to be 94.5 nm. Moreover, the MRI tests showed a favourable T1-weighted MRI performance of the LDH-Fe nanoring with r1 values of 0.54 and 1.68, and low r2/r1 ratios of 10.1 and 6.3, pre- and after calcination, respectively. The nanoparticles also showed high model drug (ibuprofen loading capacities, low Fe3+ leakage, and negligible cytotoxicity. All these results demonstrate the potential of LDH-Fe nanorings as an imageable drug delivery system.

  7. A double-blind randomized controlled trial to assess the effect of bright light therapy on depression in patients with Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Sonja Rutten

    2016-10-01

    Full Text Available Abstract Background A disturbed circadian rhythm seems to be a causal factor in the occurrence of depressive disorders in patients with Parkinson’s disease (PD. The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT might be a new treatment option for depression in PD patients. Methods/design In this double-blind controlled trial, 84 subjects with idiopathic PD are randomized to either BLT or a control light condition. The BLT condition emits white light with an intensity of 10,000 Lux, while the control device emits dim white light of 200 Lux, which is presumed to be too low to influence the circadian rhythm. Subjects receive 30 min of home treatment twice daily for three months. Timing of treatment is based on the individual chronotype. After finishing treatment, subjects enter a follow-up period of six months. The primary outcome of the study is the severity of depressive symptoms, as measured with the Hamilton Depression Rating Scale. Secondary outcomes are alternative depression measures, objective and subjective sleep measures, and salivary melatonin and cortisol concentrations. For exploratory purposes, we also assess the effects on motor symptoms, global cognitive function, comorbid psychiatric disorders, quality of life and caregiver burden. Data will be analyzed using a linear mixed models analysis. Discussion Performing a placebo-controlled trial on the effects of BLT in PD patients is challenging, as the appearance of the light may provide clues on the treatment condition. Moreover, fixed treatment times lead to an improved sleep-wake rhythm, which also influences the circadian system. With our study design, we do not compare BLT to placebo treatment, i.e. an ineffective control treatment. Rather, we compare structuring of the sleep-wake cycle in both conditions with additional BLT in the experimental condition, and additional dim light in the control condition. Participants are not informed about

  8. Assessment of a protein cocktail-based skin test for bovine tuberculosis in a double-blind field test in cattle.

    Science.gov (United States)

    Xin, Ting; Jia, Hong; Ding, Jiabo; Li, Pingjun; Yang, Hongjun; Hou, Shaohua; Yuan, Weifeng; Guo, Xiaoyu; Wang, Haichun; Liang, Qianqian; Li, Ming; Wang, Bin; Zhu, Hongfei

    2013-04-01

    Bovine tuberculosis (bTB) is a worldwide zoonosis caused mainly by Mycobacterium bovis. The traditional diagnostic method used often is the tuberculin skin test, which uses bovine purified protein derivatives (PPD-B). However, it is difficult to maintain uniformity of PPD-B from batch to batch, and it shares common antigens with nonpathogenic environmental mycobacteria. To overcome these problems, M. bovis-specific antigens that showed good T cell stimulation, such as CFP-10, ESAT-6, Rv3615c, etc., have been used in the skin test, but there have been no large-scale clinical studies on these antigens. In this study, two combinations (CFP-10/ESAT-6/TB10.4 protein cocktail and CFP-10/ESAT-6/Rv3872/MPT63 protein cocktail) were developed and used as stimuli in the skin test. Cattle were double-blind tested to assess the efficiency of the protein cocktail-based skin tests. The results showed that the CFP-10/ESAT-6/TB10.4 protein cocktail-based skin test can differentiate TB-infected cattle from Mycobacterium avium-infected ones and that it shows a high degree of agreement with the traditional tuberculin skin test (κ = 0.8536) and gamma interferon (IFN-γ) release assay (κ = 0.8154). Compared to the tuberculin skin test, the relative sensitivity and relative specificity of the CFP-10/ESAT-6/TB10.4-based skin test were 87% and 97%, respectively., The relative sensitivity and relative specificity of the CFP-10/ESAT-6/TB10.4-based skin test were 93% and 92%, respectively, on comparison with the IFN-γ release assay. The correlation between the increases in skin thickness observed after the inoculation of stimuli was high (PPD-B versus CFP-10/ESAT-6/TB10.4, Spearman r of 0.8435). The correlation between the optical density at 450 nm (OD450) obtained after blood stimulation with PPD-B and the increase in skin thickness observed after inoculation of the CFP-10/ESAT-6/TB10.4 protein cocktail was high (Spearman r = 0.7335). Therefore, the CFP-10/ESAT-6/TB10.4-based skin test

  9. A randomized double blind crossover placebo-controlled clinical trial to assess the effects of a mouthwash containing chlorine dioxide on oral malodor

    Directory of Open Access Journals (Sweden)

    Yokoyama Sayaka

    2008-12-01

    Full Text Available Abstract Background Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2, however, its clinical efficacies on oral malodor have been evaluated only with organoleptic measurements (OM or sulphide monitors. No clinical studies have investigated the inhibitory effects of ClO2 on volatile sulfur compounds (VSCs using gas chromatography (GC. The aim of this study was to assess the inhibitory effects of a mouthwash containing ClO2 on morning oral malodor using OM and GC. Methods A randomized, double blind, crossover, placebo-controlled clinical trial was conducted among 15 healthy male volunteers, who were divided into 2 groups. In the first test phase, the group 1 subjects (N = 8 were instructed to rinse with the experimental mouthwash containing ClO2, and those in group 2 (N = 7 to rinse with the placebo mouthwash without ClO2. In the second test, phase after a one week washout period, each group used the opposite mouthwash. Oral malodor was evaluated before rinsing, right after rinsing and every 30 minutes up to 4 hours with OM, and concentrations of hydrogen sulfide (H2S, methyl mercaptan (CH3SH and dimethyl sulfide ((CH32S, the main VSCs of human oral malodor, were evaluated with GC. Results The baseline oral condition in the subjects in the 2 groups did not differ significantly. The mouthwash containing ClO2 improved morning bad breath according to OM and reduced concentrations of H2S, CH3SH and (CH32S according to GC up to 4 hours after rinsing. OM scores with ClO2 were significantly lower than those without ClO2 at all examination times. Significant reductions in the concentrations of the three kinds of VSCs measured by GC were also evident at all examination times. The concentrations of the three gases with ClO2 were significantly lower than those without ClO2 at most examination times. Conclusion In this explorative study, ClO2 mouthwash was effective at reducing morning malodor for 4

  10. A double-blind randomized controlled trial to assess the effect of bright light therapy on depression in patients with Parkinson's disease.

    Science.gov (United States)

    Rutten, Sonja; Vriend, Chris; Smit, Jan H; Berendse, Henk W; Hoogendoorn, Adriaan W; van den Heuvel, Odile A; van der Werf, Ysbrand D

    2016-10-21

    A disturbed circadian rhythm seems to be a causal factor in the occurrence of depressive disorders in patients with Parkinson's disease (PD). The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT) might be a new treatment option for depression in PD patients. In this double-blind controlled trial, 84 subjects with idiopathic PD are randomized to either BLT or a control light condition. The BLT condition emits white light with an intensity of 10,000 Lux, while the control device emits dim white light of 200 Lux, which is presumed to be too low to influence the circadian rhythm. Subjects receive 30 min of home treatment twice daily for three months. Timing of treatment is based on the individual chronotype. After finishing treatment, subjects enter a follow-up period of six months. The primary outcome of the study is the severity of depressive symptoms, as measured with the Hamilton Depression Rating Scale. Secondary outcomes are alternative depression measures, objective and subjective sleep measures, and salivary melatonin and cortisol concentrations. For exploratory purposes, we also assess the effects on motor symptoms, global cognitive function, comorbid psychiatric disorders, quality of life and caregiver burden. Data will be analyzed using a linear mixed models analysis. Performing a placebo-controlled trial on the effects of BLT in PD patients is challenging, as the appearance of the light may provide clues on the treatment condition. Moreover, fixed treatment times lead to an improved sleep-wake rhythm, which also influences the circadian system. With our study design, we do not compare BLT to placebo treatment, i.e. an ineffective control treatment. Rather, we compare structuring of the sleep-wake cycle in both conditions with additional BLT in the experimental condition, and additional dim light in the control condition. Participants are not informed about the exact details of the two light devices and the expected

  11. Randomized double-blind controlled Phase I/IIa trial to assess the efficacy of malaria vaccine PfCS102 to protect against challenge with P. falciparum.

    NARCIS (Netherlands)

    Genton, B.; D'Acremont, V.; Lurati-Ruiz, F.; Verhage, D.F.; Audran, R.; Hermsen, C.C.; Wolters, L.; Reymond, C.; Spertini, F.; Sauerwein, R.W.

    2010-01-01

    The aim of this Phase I/IIa double-blind controlled trial was to test the efficacy of the sporozoite-based malaria vaccine PfCS 282-383 (PfCS102) to protect against Plasmodium falciparum parasitaemia. 16 volunteers were randomized to receive twice 30 mug of PfCS102 formulated in Montanide ISA 720 or

  12. Assessing double counting of carbon emissions between forest land cover change and forest wildfires: a case study in the United States, 1992-2006

    Science.gov (United States)

    Daolan Zheng; Linda S. Heath; Mark J. Ducey; Brad. Quayle

    2013-01-01

    The relative contributions of double counting of carbon emissions between forest-to-nonforest cover change (FNCC) and forest wildfires are an unknown in estimating net forest carbon exchanges at large scales. This study employed land-cover change maps and forest fire data in the four representative states (Arkansas, California, Minnesota, and Washington) of the US for...

  13. Statistical properties of measures of association and the Kappa statistic for assessing the accuracy of remotely sensed data using double sampling

    Science.gov (United States)

    Mohammed A. Kalkhan; Robin M. Reich; Raymond L. Czaplewski

    1996-01-01

    A Monte Carlo simulation was used to evaluate the statistical properties of measures of association and the Kappa statistic under double sampling with replacement. Three error matrices representing three levels of classification accuracy of Landsat TM Data consisting of four forest cover types in North Carolina. The overall accuracy of the five indices ranged from 0.35...

  14. Analysis of stroke in ATHENA: a placebo-controlled, double-blind, parallel-arm trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation/atrial flutter

    DEFF Research Database (Denmark)

    Connolly, Stuart J; Crijns, Harry J G M; Torp-Pedersen, Christian

    2009-01-01

    , on stroke has been evaluated in a randomized, double-blind clinical trial, ATHENA (A placebo-controlled, double-blind, parallel-arm Trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation...

  15. Double outlet right ventricle

    Science.gov (United States)

    ... medlineplus.gov/ency/article/007328.htm Double outlet right ventricle To use the sharing features on this page, please enable JavaScript. Double outlet right ventricle (DORV) is a heart disease that is ...

  16. Anatomic double-bundle and over-the-top single-bundle with additional extra-articular tenodesis: an in vivo quantitative assessment of knee laxity in two different ACL reconstructions.

    Science.gov (United States)

    Zaffagnini, S; Signorelli, C; Lopomo, N; Bonanzinga, T; Marcheggiani Muccioli, G M; Bignozzi, S; Visani, A; Marcacci, M

    2012-01-01

    Combinations of intra- and extra-articular procedures have been proposed for anterior cruciate ligament reconstruction with the aim of achieving an optimal control of translational and rotational knee laxities. Recently, the need for better reproducing the structural and functional behavior of the native anterior cruciate ligament led to the definition of anatomic double-bundle surgical approach. This study aimed to quantitatively verify whether the in vivo static and dynamic behavior obtained using over-the-top single-bundle with extra-articular tenodesis reconstruction was comparable to the results achieved by anatomic double-bundle approach. Thirty-five consecutive patients, with an isolated anterior cruciate ligament injury, were included in the study. Standard clinical laxities and pivot-shift test were quantified before and after anterior cruciate ligament reconstruction by means of a surgical navigation system dedicated to kinematic assessment; displacements of medial and lateral compartment during stress tests were also analyzed. Single-bundle with extra-articular tenodesis approach presented statistically better laxity reduction in varus/valgus stress test at full extension and in internal/external rotation at 90° of flexion; lateral plasty controlled better the lateral compartment during drawer test and varus/valgus stress test both at 0° and 30° of flexion and both the compartments during internal/external rotation at 90° of flexion. On the other hand, pivot-shift phenomenon was better controlled by anatomic double-bundle reconstruction. Both the reconstructions worked similarly for static knee laxity. The extra-articular procedure played an important role in better constraining the displacement of lateral tibial compartment, whereas the anatomic double-bundle reconstruction better restored the dynamic behavior of knee joint highlighted under pivot-shift stress test. Case series.

  17. Double Outlet Right Ventricle

    Science.gov (United States)

    ... Right Ventricle Menu Topics Topics FAQs Double Outlet Right Ventricle Double outlet right ventricle (DORV) is a rare form of congenital heart disease. Article Info En español Double outlet right ventricle (DORV) is a rare form of congenital ...

  18. Anatomic assessment of femoral tunnel by transtibial drilling technique in double-bundle anterior cruciate ligament reconstruction:an in vivo study

    Directory of Open Access Journals (Sweden)

    XU Hu

    2013-10-01

    Full Text Available 【Abstract】Objective: To evaluate the anatomy of femoral tunnels created by simulated transtibial technique in double-bundle anterior cruciate ligament (ACL reconstruction. Methods: Two tibial tunnels, anteromedial (AM and posterolateral (PL, were drilled 45° and 55° to tibial plateau respectively. On the femoral side, the AM and PL tunnels were drilled through anteriomedial portal. Af ter the four tunnels were established, the shaft of a reamer was introduced into the joint through tibial tunnel and reached gainst the lateral wall of intercondylar notch. The position that the reamer shaf t can reach was marked and recorded. Results: Neither femoral AM nor PL tunnel opening can be fully or partially reached by the reamer shaft through the tibial AM tunnel in all cases. The evaluation thr ough the tibial PL tunnel showed that only in 8 of 50 cases (16% the femoral AM tunnel opening and in 4 cases (8% the PL opening can be fully reached. On the other hand, in 12 cases (24 % the femoral AM tunnel opening and in 0 cases ( 20% the PL opening can be partially reached by the shafts through the tibial PL tunnel. Conclusion: The result strongly suggests that transtibial technique is not well competent for femoral tunnel drilling in anatomic double-bundle ACL reconstruction as we have hypothesized. Key words: Anterior cruciate ligament reconstr uction; Arthroscopy; Anatomy; Knee

  19. Residual electric fields of InGaAs/AlAs/AlAsSb (001) coupled double quantum wells structures assessed by photoreflectance anisotropy

    Science.gov (United States)

    González-Fernández, J. V.; Herrera-Jasso, R.; Ulloa-Castillo, N. A.; Ortega-Gallegos, J.; Castro-García, R.; Lastras-Martínez, L. F.; Lastras-Martínez, A.; Balderas-Navarro, R. E.; Mozume, T.; Gozu, S.

    2016-12-01

    We report on photoreflectance anisotropy (PRA) spectroscopy of InGaAs/AlAs/AlAsSb coupled double quantum wells (CDQWs) with extremely thin coupling AlAs barriers grown by molecular beam epitaxy (MBE), with no intentional doping. By probing the in-plane interfacial optical anisotropies (OAs), it is shown that PRA spectroscopy has the ability to detect and distinguish semiconductor layers with quantum dimensions, as the anisotropic photoreflectance (PR) signal stems entirely from buried quantum wells (QWs). In order to account for the experimental PRA spectra, a theoretical model at k = 0, based on a linear electro-optic effect through a piezoelectric shear strain, has been employed to quantify the internal electric fields across the QWs. The dimensionalities of the PR lineshapes were tested by using reciprocal (Fourier) space analysis. Such a complementary test is used in order to correctly employ the PRA model developed here.

  20. Light Scattering and Current Enhancement for Microcrystalline Silicon Thin-Film Solar Cells on Aluminium-Induced Texture Glass Superstrates with Double Texture

    Directory of Open Access Journals (Sweden)

    Yunfeng Yin

    2015-01-01

    Full Text Available Microcrystalline silicon (μc-Si:H thin-film solar cells are processed on glass superstrates having both micro- and nanoscale surface textures. The microscale texture is realised at the glass surface, using the aluminium-induced texturing (AIT method, which is an industrially feasible process enabling a wide range of surface feature sizes (i.e., 700 nm–3 μm of the textured glass. The nanoscale texture is made by conventional acid etching of the sputter-deposited transparent conductive oxide (TCO. The influence of the resulting “double texture” on the optical scattering is investigated by means of atomic force microscopy (AFM (studying the surface topology, haze measurements (studying scattering into air, and short-circuit current enhancement measurements (studying scattering into silicon. A predicted enhanced optical scattering efficiency is experimentally proven by a short-circuit current enhancement ΔIsc of up to 1.6 mA/cm2 (7.7% relative increase compared to solar cells fabricated on a standard superstrate, that is, planar glass covered with nanotextured TCO. Enhancing the autocorrelation length (or feature size of the AIT superstrates might have the large potential to improve the μc-Si:H thin-film solar cell efficiency, by reducing the shunting probability of the device while maintaining a high optical scattering performance.

  1. The double identity of linguistic doubling.

    Science.gov (United States)

    Berent, Iris; Bat-El, Outi; Brentari, Diane; Dupuis, Amanda; Vaknin-Nusbaum, Vered

    2016-11-29

    Does knowledge of language consist of abstract principles, or is it fully embodied in the sensorimotor system? To address this question, we investigate the double identity of doubling (e.g., slaflaf, or generally, XX; where X stands for a phonological constituent). Across languages, doubling is known to elicit conflicting preferences at different levels of linguistic analysis (phonology vs. morphology). Here, we show that these preferences are active in the brains of individual speakers, and they are demonstrably distinct from sensorimotor pressures. We first demonstrate that doubling in novel English words elicits divergent percepts: Viewed as meaningless (phonological) forms, doubling is disliked (e.g., slaflaf Language, and their capacity to do so depends on the structure of their spoken language (English vs. Hebrew). These results demonstrate that linguistic preferences doubly dissociate from sensorimotor demands: A single stimulus can elicit diverse percepts, yet these percepts are invariant across stimulus modality--for speech and signs. These conclusions are in line with the possibility that some linguistic principles are abstract, and they apply broadly across language modality.

  2. Project Half Double

    DEFF Research Database (Denmark)

    Svejvig, Per; Ehlers, Michael; Adland, Karoline Thorp

    activities carried out within the framework of the projects. The formal part of Project Half Double was initiated in June 2015. We started out by developing, refining and testing the Half Double methodology on seven pilot projects in the first phase of the project, which will end June 2016. The current...... many of the key performance indicators associated with them can be evaluated (Grundfos and Siemens Wind Power). In addition to the current status of delivering impact faster for the seven pilot projects, it is important to highlight that Project Half Double phase 1 has planted many seeds in the pilot...... organisations concerning project methodology and beyond. The many learning points from each pilot project show that Project Half Double has left its clear footprint in the pilot organisations, and that the Half Double methodology has evolved and developed very much during Project Half Double phase 1....

  3. Double sequence core theorems

    Directory of Open Access Journals (Sweden)

    Richard F. Patterson

    1999-01-01

    Full Text Available In 1900, Pringsheim gave a definition of the convergence of double sequences. In this paper, that notion is extended by presenting definitions for the limit inferior and limit superior of double sequences. Also the core of a double sequence is defined. By using these definitions and the notion of regularity for 4-dimensional matrices, extensions, and variations of the Knopp Core theorem are proved.

  4. Evaluation and guidelines for using polyurethane foam (PUF) passive air samplers in double-dome chambers to assess semi-volatile organic compounds (SVOCs) in non-industrial indoor environments.

    Science.gov (United States)

    Bohlin, Pernilla; Audy, Ondřej; Škrdlíková, Lenka; Kukučka, Petr; Vojta, Šimon; Přibylová, Petra; Prokeš, Roman; Čupr, Pavel; Klánová, Jana

    2014-11-01

    Indoor air pollution has been recognized as an important risk factor for human health, especially in areas where people tend to spend most of their time indoors. Many semi-volatile organic compounds (SVOCs) have primarily indoor sources and are present in orders of magnitude higher concentrations indoors than outdoors. Despite this, awareness of SVOCs in indoor air and assessment of the link between indoor concentrations and human health have lagged behind those of outdoor air. This is partially related to challenges associated with indoor sampling of SVOCs. Passive air samplers (PASs), which are widely accepted in established outdoor air monitoring networks, have been used to fill the knowledge gaps on indoor SVOCs distribution. However, their applicability for indoor environments and the assessment of human health risks lack sufficient experimental data. To address this issue, we performed an indoor calibration study of polyurethane foam (PUF) PAS deployed in a double-dome chamber, covering both legacy and new SVOC classes. PUF-PAS and a continuous low-volume active air sampler (AAS) were co-deployed for a calibration period of twelve weeks. Based on the results from this evaluation, PUF-PAS in a double-bowl chamber is recommended for indoor sampling and health risk assessment of gas phase SVOCs, including novel brominated flame retardants (nBFR) providing sufficient exposure time is applied. Data for particle associated SVOCs suffered from significant uncertainties caused by low level of detection and low precision in this study. A more open chamber design for indoor studies may allow for higher sampling rates (RS) and better performance for the particle associated SVOCs.

  5. Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy of Nonopioid Analgesics on Pain following Arthroscopic Knee Surgery.

    Science.gov (United States)

    Abdulla, Susanne; Eckhardt, Regina; Netter, Ute; Abdulla, Walied

    2012-01-01

    Purpose. In a randomized, double-blind trial, the efficacy of nonopioid analgesics on postoperative piritramide consumption was compared for pain relief during the first 24 h in patients recovering from arthroscopic knee surgery. Methods. 120 patients were treated with normal saline and/or one of the nonopioid analgesics (parecoxib, metamizole, paracetamol) in addition to piritramide using the PCA pump. Beginning in the postanesthesia care unit (PACU), patients were asked to quantify their pain experience at rest while piritramide consumption was recorded. Results. Piritramide consumption upon arrival in the PACU was high in all groups. However, cumulative consumption in the parecoxib group was significantly lower than that in the placebo group at 6 and 12 h after surgery. At discharge from the PACU, VAS scores dropped in all groups and were significantly lower in the parecoxib group. In the PACU, satisfaction of the patients was moderate and improved with time after surgery. Conclusions. There was statistically significant opioid-saving effect by administering parecoxib with better VAS scores and satisfaction level compared to placebo. The high pain score in the PACU in all groups immediately after recovering from remifentanil-based anesthesia would be prevented if local anesthetics were administered intra-articularly as part of a multimodal analgesic approach.

  6. Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy of Nonopioid Analgesics on Pain following Arthroscopic Knee Surgery

    Directory of Open Access Journals (Sweden)

    Susanne Abdulla

    2012-01-01

    Full Text Available Purpose. In a randomized, double-blind trial, the efficacy of nonopioid analgesics on postoperative piritramide consumption was compared for pain relief during the first 24 h in patients recovering from arthroscopic knee surgery. Methods. 120 patients were treated with normal saline and/or one of the nonopioid analgesics (parecoxib, metamizole, paracetamol in addition to piritramide using the PCA pump. Beginning in the postanesthesia care unit (PACU, patients were asked to quantify their pain experience at rest while piritramide consumption was recorded. Results. Piritramide consumption upon arrival in the PACU was high in all groups. However, cumulative consumption in the parecoxib group was significantly lower than that in the placebo group at 6 and 12 h after surgery. At discharge from the PACU, VAS scores dropped in all groups and were significantly lower in the parecoxib group. In the PACU, satisfaction of the patients was moderate and improved with time after surgery. Conclusions. There was statistically significant opioid-saving effect by administering parecoxib with better VAS scores and satisfaction level compared to placebo. The high pain score in the PACU in all groups immediately after recovering from remifentanil-based anesthesia would be prevented if local anesthetics were administered intra-articularly as part of a multimodal analgesic approach.

  7. Assessing the Detection Limit of a Minority Solid-State Form of a Pharmaceutical by 1H Double-Quantum Magic-Angle Spinning Nuclear Magnetic Resonance Spectroscopy.

    Science.gov (United States)

    Maruyoshi, Keisuke; Iuga, Dinu; Watts, Abigail E; Hughes, Colan E; Harris, Kenneth D M; Brown, Steven P

    2017-11-01

    The lower detection limit for 2 distinct crystalline phases by 1H magic-angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) is investigated for a minority amount of cimetidine (anhydrous polymorph A) in a physical mixture with the anhydrous HCl salt of cimetidine. Specifically, 2-dimensional 1H double-quantum (DQ) MAS NMR spectra of polymorph A and the anhydrous HCl salt constitute fingerprints for the presence of each of these solid forms. For solid-state NMR data recorded at a 1H Larmor frequency of 850 MHz and a MAS frequency of 30 kHz on ∼10 mg of sample, it is shown that, by following the pair of cross-peaks at a 1H DQ frequency of 7.4 + 11.6 = 19.0 ppm that are unique to polymorph A, the level of detection for polymorph A in a physical mixture with the anhydrous HCl salt is a concentration of 1% w/w. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  8. Assessing the effect of docosahexaenoic acid on cognitive functions in healthy, preschool children: a randomized, placebo-controlled, double-blind study.

    Science.gov (United States)

    Ryan, Alan S; Nelson, Edward B

    2008-05-01

    The utility of multicenter cognitive test methodology and resultant outcomes of supplementation with docosahexaenoic acid in healthy 4-year-old children was evaluated in a randomized, placebo-controlled, double-blind study. Subjects received 400-mg/d docosahexaenoic acid (n = 85) or matching placebo (n = 90) in capsules for 4 months. Cognitive tests included the Leiter-R Test of Sustained Attention, Peabody Picture Vocabulary Test, Day-Night Stroop Test, and Conners' Kiddie Continuous Performance Test. The relationship of docosahexaenoic acid levels in capillary whole blood from a subsample (n = 93) with scores on cognitive tests was evaluated. For each test, results indicated that changes from baseline to end of treatment were not statistically significantly different between the docosahexaenoic acid group and the placebo group. Regression analysis, however, yielded a statistically significant positive (P = .018) association between the blood level of docosahexaenoic acid and higher scores on the Peabody Picture Vocabulary Test, a test of listening comprehension and vocabulary acquisition.

  9. Assessment of amide I spectroscopic maps for a gas-phase peptide using IR-UV double-resonance spectroscopy and density functional theory calculations

    Science.gov (United States)

    Carr, J. K.; Zabuga, A. V.; Roy, S.; Rizzo, T. R.; Skinner, J. L.

    2014-01-01

    The spectroscopy of amide I vibrations has become a powerful tool for exploring protein structure and dynamics. To help with spectral interpretation, it is often useful to perform molecular dynamics (MD) simulations. To connect spectroscopic experiments to simulations in an efficient manner, several researchers have proposed “maps,” which relate observables in classical MD simulations to quantum spectroscopic variables. It can be difficult to discern whether errors in the theoretical results (compared to experiment) arise from inaccuracies in the MD trajectories or in the maps themselves. In this work, we evaluate spectroscopic maps independently from MD simulations by comparing experimental and theoretical spectra for a single conformation of the α-helical model peptide Ac-Phe-(Ala)5-Lys-H+ in the gas phase. Conformation-specific experimental spectra are obtained for the unlabeled peptide and for several singly and doubly 13C-labeled variants using infrared-ultraviolet double-resonance spectroscopy, and these spectra are found to be well-modeled by density functional theory (DFT) calculations at the B3LYP/6-31G** level. We then compare DFT results for the deuterated and 13C18O-labeled peptide with those from spectroscopic maps developed and used previously by the Skinner group. We find that the maps are typically accurate to within a few cm−1 for both frequencies and couplings, having larger errors only for the frequencies of terminal amides. PMID:24929378

  10. Assessment of anti-recombination and double-strand break-induced gene conversion in human cells by a chromosomal reporter.

    Science.gov (United States)

    Xu, Keqian; Wu, Xiling; Tompkins, Joshua D; Her, Chengtao

    2012-08-24

    Gene conversion is one of the frequent end results of homologous recombination, and it often underlies the inactivation of tumor suppressor genes in cancer cells. Here, we have developed an integrated assay system that allows simultaneous examination of double-strand break (DSB)-induced gene conversion events at the site of a DSB (proximal region) and at a surrounding region ~1 kb away from the break (distal region). Utilizing this assay system, we find that gene conversion events at the proximal and distal regions are relatively independent of one another. The results also indicate that synthesis-dependent strand annealing (SDSA) plays a major role in DSB-induced gene conversion. In addition, our current study has demonstrated that hMLH1 plays an essential role in anti-recombination and gene conversion. Specifically, the anti-recombination activity of hMLH1 is partially dependent on its interaction with hMRE11. Our data suggests that the role of hMLH1 and hMRE11 in the process of gene conversion is complex, and these proteins play different roles in DSB-induced proximal and distal gene conversions. In particular, the involvement of hMLH1 and hMRE11 in the distal gene conversion requires both hMSH2 and heteroduplex formation.

  11. Assessment of Anti-recombination and Double-strand Break-induced Gene Conversion in Human Cells by a Chromosomal Reporter*

    Science.gov (United States)

    Xu, Keqian; Wu, Xiling; Tompkins, Joshua D.; Her, Chengtao

    2012-01-01

    Gene conversion is one of the frequent end results of homologous recombination, and it often underlies the inactivation of tumor suppressor genes in cancer cells. Here, we have developed an integrated assay system that allows simultaneous examination of double-strand break (DSB)-induced gene conversion events at the site of a DSB (proximal region) and at a surrounding region ∼1 kb away from the break (distal region). Utilizing this assay system, we find that gene conversion events at the proximal and distal regions are relatively independent of one another. The results also indicate that synthesis-dependent strand annealing (SDSA) plays a major role in DSB-induced gene conversion. In addition, our current study has demonstrated that hMLH1 plays an essential role in anti-recombination and gene conversion. Specifically, the anti-recombination activity of hMLH1 is partially dependent on its interaction with hMRE11. Our data suggests that the role of hMLH1 and hMRE11 in the process of gene conversion is complex, and these proteins play different roles in DSB-induced proximal and distal gene conversions. In particular, the involvement of hMLH1 and hMRE11 in the distal gene conversion requires both hMSH2 and heteroduplex formation. PMID:22773873

  12. Neutrinoless double beta decay

    Indian Academy of Sciences (India)

    2012-10-06

    Oct 6, 2012 ... The physics potential of neutrinoless double beta decay is discussed. Furthermore, experimental considerations as well as the current status of experiments are presented. Finally, an outlook towards the future, work on nuclear matrix elements and alternative processes is given. Keywords. Double beta ...

  13. A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome.

    Science.gov (United States)

    Lal, Ritu; Ellenbogen, Aaron; Chen, Dan; Zomorodi, Katie; Atluri, Harisha; Luo, Wendy; Tovera, James; Hurt, Janet; Bonzo, Daniel; Lassauzet, Marie-Liesse; Vu, Amanda; Cundy, Kenneth C

    2012-01-01

    The objective of this study was to determine steady-state gabapentin exposures and corresponding relief of symptoms and safety profile produced by 4 dose levels of gabapentin enacarbil (GEn) in subjects with restless legs syndrome (RLS). Subjects with RLS (n = 217) were randomized to receive once-daily, orally administered GEn 600 (n = 48), 1200 (n = 45), 1800 (n = 38), or 2400 mg (n = 45) or placebo (n = 41) in this 12-week, double-blind, multicenter study (NCT01332305). Clinic visits were at screening, baseline, and weeks 1, 2, 3, 4, 6, 8, 10, and 12; plasma gabapentin concentrations were measured by a validated liquid chromatography-mass spectrometry/mass spectrometry method at weeks 4 and 12. Exposure to gabapentin was proportional to GEn dose. Time to maximum plasma concentration was 7 to 9 hours, and elimination half-life was ~6 hours. The mean reduction from baseline to week 12 in International Restless Legs Syndrome Rating Scale total score and proportions of subjects with "much improved"/"very much improved" Clinical Global Impression-Improvement scores (investigator and patient ratings) ranged from -12.9 to -13.9 for GEn treatment groups versus -9.3 for placebo. The 2 most commonly reported adverse events were somnolence and dizziness. Gabapentin exposure was approximately proportional to GEn dose. Efficacy data showed that a once-daily dose of GEn 600 to 2400 mg provides greater relief of RLS symptoms than placebo; GEn was generally well tolerated with an adverse event profile consistent with gabapentin.

  14. MRI assessment of erosion repair in patients with long-standing rheumatoid arthritis receiving double-filtration plasmapheresis in addition to leflunomide and methotrexate: a randomized controlled trial.

    Science.gov (United States)

    Yu, Xiaoxia; Zhang, Lei; Wang, Lixin; Lu, Weiwei; Sun, Fengyan; Xu, Ping; Lan, Guobin

    2018-01-08

    The objective of this study is to investigate whether the addition of double-filtration plasmapheresis (DFPP) to leflunomide and methotrexate repairs MRI bone erosion in patients with long-standing rheumatoid arthritis (RA). Seventy-two patients with highly active RA of > 3 years' duration were randomized to receive DFPP in addition to DMARDs (leflunomide and methotrexate) or DMARDs. Contrast-enhanced MRI of the right wrist was performed at months 0, 6, and 12. MRI bone erosion, synovitis, and bone edema were scored with validated methods. The primary endpoint was the change in MRI bone erosion over 12 months. Patients treated with DFPP in addition to DMARDs demonstrated significantly greater decrease in MRI erosion score compared with those treated with DMARDs, being 11.3 ± 9.6 at month 12, compared with 16.9 ± 8.3 in patients with DMARDs (P erosion score. Synovitis and bone edema improved significantly with DFPP in addition to DMARDs compared with DMARDs at months 6 and 12. (1.05 ± 1.7 and 2.0 ± 3.9 compared with 8.0 ± 1.4 and 12.6 ± 7.9 at month 12). Patients without synovitis and bone edema reached in 55.3% among patients with DFPP in addition to DMARDs. This study demonstrated that DFPP combination therapy significantly decreased bone erosion and received the primary goal of repair of erosions through abrogating MRI inflammation (synovitis and bone edema) in long-standing RA patients with high disease activity. The findings suggest that addition of DFPP is associated with repair of erosions and further suppression of inflammation.

  15. A double-blind randomized controlled trial to assess the efficacy of daylight photodynamic therapy with methyl-aminolevulinate vs. Placebo and daylight in patients with facial photodamage.

    Science.gov (United States)

    Sanclemente, G; Mancilla, G A; Hernandez, G

    2016-04-01

    Daylight PDT (dPDT) is easy to use and does not require light equipment. Such therapy has been exhaustively proved to be successful in the treatment of actinic keratosis, but its use in skin photodamage remains unclear. To evaluate dPDT's efficacy in skin facial photodamage. This was a parallel-group double-blind, randomized placebo-controlled trial. Sixty participants with symmetric facial photodamage were allocated to topical methyl aminolevulinate (MAL) and daylight vs. matching placebo and daylight. Primary outcome was global photodamage improvement/failure 1 month after the third session. Secondary outcomes included: pain evaluation; specific photodamage severity scores; sun irradiance quantification and Skindex-29 scores. Adverse events were also investigated. Primary analysis included all randomized patients. All patients sun-exposed for 120min in 3 sessions. The risk of failure was lower in the MAL-dPDT group than in the placebo plus daylight group (RR: 0.18; 95% CI: 0.08-0.41). Mean solar irradiance (W/m(2)) during the first, second and third sessions was 480.82, 430.07 and 435.84, respectively. Items 5 and 14 of Skindex-29 in the MAL-dPDT group showed statistical significant differences. Two patients in the MAL-dPDT group had serious and non-serious events not directly related to the product. dPDT with MAL was un-painful, effective and safe for the treatment of facial photodamage. Herpes simplex prophylaxis should be considered before sessions. Copyright © 2015 AEDV. Published by Elsevier España, S.L.U. All rights reserved.

  16. Introduction of peanuts in younger siblings of children with peanut allergy: a prospective, double-blinded assessment of risk, of diagnostic tests, and an analysis of patient preferences.

    Science.gov (United States)

    Bégin, P; Graham, F; Killer, K; Paradis, J; Paradis, L; Des Roches, A

    2016-12-01

    The prevalence of peanut allergy in younger siblings of children with peanut allergy has been reported between 7% and 8.5%, but the anaphylactic risk at the time of introduction is currently unknown, which limits our ability to best counsel parents on this issue. To determine the risk of anaphylaxis and working parameters of allergy testing in this context. One hundred and fifty-four peanut-naïve younger siblings of peanut-allergic children underwent double-blinded skin testing, followed by parent-led peanut introduction. Questionnaires were dispensed to parents to investigate preferences with regard to peanut introduction in this subgroup. Eight participants (5.2%) presented unequivocal IgE-mediated reactions to peanut upon introduction, including five anaphylaxes. These participants were significantly older compared to the rest of the cohort (median 4.0 vs 1.9 years, P = 0.04). The negative predictive value of skin prick test with peanut extract and peanut butter and of specific IgE was 99%, 100%, and 100%, respectively. Six peanut-tolerant participants had positive peanut allergy tests. The option of introducing at home without prior skin testing was associated with high levels of anxiety (median 8.4 on 10-point Likert scale) when compared to supervised introduction (median 3.8, P introduction after negative skin test (median 4.3, P introduction in siblings of children with peanut allergy, and parents are reluctant to introduce at home without testing. Allergy testing prior to introduction is negative in over 90% of cases and carries a high negative predictive value. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Assessment of the diagnostic accuracy of double inversion recovery sequence compared with FLAIR and T2W_TSE in detection of cerebral multiple sclerosis lesions.

    Science.gov (United States)

    Abidi, Zahra; Faeghi, Fariborz; Mardanshahi, Zahra; Mortazavi, Hasan

    2017-04-01

    Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. MRI has an important role in early diagnosis of MS within diagnostic criteria. To determine the diagnostic value of the double inversion recovery (DIR) sequence in detection of brain MS lesions. In this cross-sectional study, 55 patients were admitted to the MRI department in Vali-E-Asr Hospital in Qaemshahr, Iran, from May 2016 to February 2016. Imaging was performed on a 1.5T Philips MR system using DIR, fluid attenuated inversion recovery (FLAIR), and T2-weighted turbo spin echo (T2W_TSE) sequences with the same parameters, including field of view (FOV), matrix, slice thickness, voxel size, and number of signal averaging (NSA). The DIR sequence has two different time inversions (TI1=3400, TI2=325ms): suppressing cerebrospinal fluid (CSF) and white matter signal. Data analysis was performed using the SPSS version 20, and p-value was gained from the patient-wise analysis by Wilcoxon analysis and paired samples t-test for matched pairs. More lesions in number and size were depicted on the DIR sequence compared with FLAIR (p=0.000 with a relative ratio of 6) and T2W_TSE (p=0.000 with a relative ratio of 10). DIR demonstrated significantly more intracortical lesions compared with FLAIR (p=0.000 with a relative ratio of 2.53) and T2W_TSE (p=0.000 and relative ratio of 8.87). There was significantly higher contrast ratio between the white matter lesions and the normal appearing white matter (NAWM) in all anatomical regions especially in deep white matter (p=0.001). An increasing total number of MS lesions can be detected by DIR sequence; thus, we recommend adding DIR sequence in routine MR protocols for MS patients.

  18. The value of qualitative and quantitative assessment of lesion to cerebral cortex signal ratio on double inversion recovery sequence in the differentiation of demyelinating plaques from non-specific T2 hyperintensities.

    Science.gov (United States)

    Hamcan, Salih; Battal, Bilal; Akgun, Veysel; Oz, Oguzhan; Bozkurt, Yalcin; Tasdemir, Serdar; Sari, Sebahattin; Tasar, Mustafa

    2017-02-01

    To assess the usefulness of the visual assessment and to determine diagnostic value of the lesion-to-cerebral cortex signal ratio (LCSR) measurement in the differentiation of demyelinating plaques and non-specific T2 hyperintensities on double inversion recovery (DIR) sequence. DIR and fluid-attenuated inversion recovery (FLAIR) sequences of 25 clinically diagnosed multiple sclerosis (MS) patients and 25 non-MS patients with non-specific T2-hyperintense lesions were evaluated visually and LCSRs were measured by two observers independently. On DIR sequence, the calculated mean LCSR ± SD for demyelinating plaques and non-specific T2-hyperintense lesions were 1.60 ± 0.26 and 0.75 ± 0.19 for observer1, and 1.61 ± 0.27 and 0.74 ± 0.19 for observer2. LCSRs of demyelinating plaques were significantly higher than other non-specific T2-hyperintense lesions on DIR sequence. By using the visual assessment demyelinating plaques were differentiated from non-specific T2-hyperintensities with 92.8 % sensitivity, 97.5 % specificity and 95.1 % accuracy for observer1 and 92.8 % sensitivity, 95 % specificity and 93.9 % accuracy for observer2. Visual assessment and LCSR measurement on DIR sequence seems to be useful for differentiating demyelinating MS plaques from supratentorial non-specific T2 hyperintensities. This feature can be used for diagnosis of MS particularly in patients with only supratentorial T2-hyperintense lesions who are categorized as radiologically possible MS. • Demyelinating plaques and non-specific T2-hyperintensities have different SI on DIR images. • These differences can be assessed by LCSR measurement or visual assessment. • There is an excellent inter-observer agreement for both methods. • This feature can be used in radiologically possible MS cases.

  19. Design of a randomized controlled double-blind crossover clinical trial to assess the effects of saliva substitutes on bovine enamel and dentin in situ

    Directory of Open Access Journals (Sweden)

    Kielbassa Andrej M

    2011-04-01

    Full Text Available Abstract Background Hyposalivation is caused by various syndromes, diabetes, drugs, inflammation, infection, or radiotherapy of the salivary glands. Patients with hyposalivation often show an increased caries incidence. Moreover, hyposalivation is frequently accompanied by oral discomfort and impaired oral functions, and saliva substitutes are widely used to alleviate oral symptoms. However, preference of saliva substitutes due to taste, handling, and relief of oral symptoms has been discussed controversially. Some of the marketed products have shown demineralizing effects on dental hard tissues in vitro. This demineralizing potential is attributed to the undersaturation with respect to calcium phosphates. Therefore, it is important to modify the mineralizing potential of saliva substitutes to prevent carious lesions. Thus, the aim of the present study was to evaluate the effects of a possible remineralizing saliva substitute (SN; modified Saliva natura compared to a demineralizing one (G; Glandosane on mineral parameters of sound bovine dentin and enamel as well as on artificially demineralized enamel specimens in situ. Moreover, oral well-being after use of each saliva substitute was recorded. Methods/Design Using a randomized, double-blind, crossover, phase II/III in situ trial, volunteers with hyposalivation utilize removable dentures containing bovine specimens during the experimental period. The volunteers are divided into two groups, and are required to apply both saliva substitutes for seven weeks each. After both test periods, differences in mineral loss and lesion depth between values before and after exposure are evaluated based on microradiographs. The oral well-being of the volunteers before and after therapy is determined using questionnaires. With respect to the microradiographic analysis, equal mineral losses and lesion depths of enamel and dentin specimens during treatment with SN and G, and no differences in patients

  20. Congenital maxillary double lip

    Directory of Open Access Journals (Sweden)

    Dinesh Singh Chauhan

    2012-01-01

    Full Text Available Double lip, also referred to as "macrocheilia," is a rare anomaly which affects the upper lip more commonly than the lower lip. It consists of a fold of excess or redundant hypertrophic tissue on the mucosal side of the lip. The congenital double lip is believed to be present at birth and becomes more prominent after eruption of teeth. It affects esthetics and also interferes with speech and mastication. Simple surgical excision produces good functional and cosmetic results. We report a case of a non-syndromic congenital maxillary double lip in a 21-year-old male patient.

  1. THE EFFICIENCY OF TENNIS DOUBLES SCORING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Geoff Pollard

    2010-09-01

    Full Text Available In this paper a family of scoring systems for tennis doubles for testing the hypothesis that pair A is better than pair B versus the alternative hypothesis that pair B is better than A, is established. This family or benchmark of scoring systems can be used as a benchmark against which the efficiency of any doubles scoring system can be assessed. Thus, the formula for the efficiency of any doubles scoring system is derived. As in tennis singles, one scoring system based on the play-the-loser structure is shown to be more efficient than the benchmark systems. An expression for the relative efficiency of two doubles scoring systems is derived. Thus, the relative efficiency of the various scoring systems presently used in doubles can be assessed. The methods of this paper can be extended to a match between two teams of 2, 4, 8, …doubles pairs, so that it is possible to establish a measure for the relative efficiency of the various systems used for tennis contests between teams of players.

  2. Assessment of Cognitive and Neurologic Recovery in Ischemic Stroke Drug Trials: Results from a Randomized, Double-blind, Placebo-controlled Study.

    Science.gov (United States)

    Di Cesare, Franco; Mancuso, Jessica; Silver, Brian; Loudon, Peter T

    2016-01-01

    Objective. Ischemic stroke is a serious medical condition with limited therapeutic options. The evaluation of the therapeutic potential of novel pharmacological interventions is carried-out in Phase II trials. The study design, primarily intended to evaluate efficacy and safety, is a balance between utilizing as few patients as possible to minimize safety risk and enrolling sufficient patients to detect unambiguous efficacy signals. We sought to determine whether post-stroke recovery outcomes based on behavioral measures of cognitive and motor impairment yielded additional information beyond that of clinician-based methods. Design. This was a multicenter, multinational, randomized, parallel group, controlled versus placebo, efficacy, and safety study of PF-03049423 for treatment of acute ischemic stroke. Settings and participants. Our study subjects were acute ischemic stroke inpatients. Measurements. Outcome measures were derived from rating scales (Modified Rankin Scale, Barthel Index, and National Institutes of Health Stroke Scale) and behavioral tests (Box and Blocks Test, Hand Grip Strength Test, 10-Meter Walk Test, Repeatable Battery Assessment of Neuropsychological Status Naming and Coding Subtests, Line Cancellation Test, and Recognition Memory Test). Assessments were performed at Days 7, 14, 30, 60, and 90. Post-hoc analyses of correlations among the outcome measures at each measurement time point on a cohort of 137 subjects were conducted. Results. Results support the validity of measures from Box and Blocks Test, Hand Grip Strength Test, 10-Meter Walk Test, and Repeatable Battery Assessment of Neuropsychological Status Coding Subtests to monitor post-stroke recovery in clinical trial settings. Notably, the Recognition Memory Test did not show a correlation with the Modified Rankin Scale, and, in fact, did not show improvement over time. Conclusion. The behavioral measures of cognitive and motor functions included in this study may extend the evaluation

  3. Validation of the post sleep questionnaire for assessing subjects with restless legs syndrome: results from two double-blind, multicenter, placebo-controlled clinical trials

    Directory of Open Access Journals (Sweden)

    Bharmal Murtuza

    2011-04-01

    Full Text Available Abstract Background Because of the subjective nature of Restless Legs Syndrome (RLS symptoms and the impact of these symptoms on sleep, patient-reported outcomes (PROs play a prominent role as study endpoints in clinical trials investigating RLS treatments. The objective of this study was to validate a new measure, the Post Sleep Questionnaire (PSQ, to assess sleep dysfunction in subjects with moderate-to-severe RLS symptoms. Methods Pooled data were analyzed from two 12-week, randomized, placebo-controlled trials of gabapentin enacarbil (N = 540. At baseline and Week 12, subjects completed the PSQ and other validated health surveys: IRLS Rating Scale, Clinical Global Impression of Improvement (CGI-I, Profile of Mood States (POMS, Medical Outcomes Study Scale-Sleep (MOS-Sleep, and RLS-Quality of Life (RLSQoL. Pooled data were used post hoc to examine the convergent, divergent, known-group validity and the responsiveness of the PSQ. Results Convergent validity was demonstrated by significant correlations between baseline PSQ items and total scores of IRLS, POMS, RLSQoL, and the MOS-Sleep Scale (p ≤ 0.007 each. Divergent validity was demonstrated through the lack of significant correlations between PSQ items and demographic characteristics. Correlations (p Conclusions Although these analyses were potentially limited by the use of clinical trial data and not prospective data from a study conducted solely for validation purposes, the PSQ demonstrated robust psychometric properties and is a valid instrument for assessing sleep and sleep improvements in subjects with moderate-to-severe RLS symptoms. Trial Registration This study analyzed data from two registered trials, NCT00298623 and NCT00365352.

  4. The value of qualitative and quantitative assessment of lesion to cerebral cortex signal ratio on double inversion recovery sequence in the differentiation of demyelinating plaques from non-specific T2 hyperintensities

    Energy Technology Data Exchange (ETDEWEB)

    Hamcan, Salih; Battal, Bilal; Akgun, Veysel; Sari, Sebahattin; Tasar, Mustafa [Gulhane Military Medical School, Department of Radiology, Etlik, Ankara (Turkey); Oz, Oguzhan; Tasdemir, Serdar [Gulhane Military Medical School, Department of Neurology, Ankara (Turkey); Bozkurt, Yalcin [Golcuk Military Hospital, Department of Radiology, Kocaeli (Turkey)

    2017-02-15

    To assess the usefulness of the visual assessment and to determine diagnostic value of the lesion-to-cerebral cortex signal ratio (LCSR) measurement in the differentiation of demyelinating plaques and non-specific T2 hyperintensities on double inversion recovery (DIR) sequence. DIR and fluid-attenuated inversion recovery (FLAIR) sequences of 25 clinically diagnosed multiple sclerosis (MS) patients and 25 non-MS patients with non-specific T2-hyperintense lesions were evaluated visually and LCSRs were measured by two observers independently. On DIR sequence, the calculated mean LCSR ± SD for demyelinating plaques and non-specific T2-hyperintense lesions were 1.60 ± 0.26 and 0.75 ± 0.19 for observer1, and 1.61 ± 0.27 and 0.74 ± 0.19 for observer2. LCSRs of demyelinating plaques were significantly higher than other non-specific T2-hyperintense lesions on DIR sequence. By using the visual assessment demyelinating plaques were differentiated from non-specific T2-hyperintensities with 92.8 % sensitivity, 97.5 % specificity and 95.1 % accuracy for observer1 and 92.8 % sensitivity, 95 % specificity and 93.9 % accuracy for observer2. Visual assessment and LCSR measurement on DIR sequence seems to be useful for differentiating demyelinating MS plaques from supratentorial non-specific T2 hyperintensities. This feature can be used for diagnosis of MS particularly in patients with only supratentorial T2-hyperintense lesions who are categorized as radiologically possible MS. (orig.)

  5. Formation of Double Neutron Stars, Millisecond Pulsars and Double ...

    Indian Academy of Sciences (India)

    Edward P. J. Heuvel

    2017-09-12

    Sep 12, 2017 ... the double neutron stars and of double black holes is given. 2. Double neutron stars and millisecond pulsars. 2.1 Double neutron stars. In the period 1978 to 1980, Srinivasan and van den. Heuvel profoundly discussed the possible ways in which the Hulse–Taylor binary pulsar could have been formed.

  6. Assessment of the role of gabapentin in patients with supratentorial tumours undergoing craniotomy under general anaesthesia: A double-blind randomised study

    Directory of Open Access Journals (Sweden)

    Rabie Soliman

    2017-01-01

    Full Text Available Background: Gabapentin attenuates the haemodynamics, decreases the catecholamine release and has a neuroprotective effect. The aim of the present study was to assess the effect of gabapentin in patients with supratentorial brain tumours undergoing craniotomy under general anaesthesia. Methods: A radial arterial line, central venous line and ventriculostomy catheters were inserted before surgery. Anaesthesia was induced with thiopental, fentanyl and atracurium and maintained with sevoflurane, fentanyl and atracurium infusion. The study included 160 patients classified randomly into two groups: Group G: The patients received gabapentin capsules 1200 mg orally 2 h before surgery. Group C: The patients received placebo capsules. Results: The heart rate, mean arterial blood pressure and intracranial pressure decreased significantly with gabapentin as compared to the control group (P < 0.05. The dose of fentanyl and end-tidal sevoflurane was lower with gabapentin than the control group (P < 0.05. The urine output was higher in the gabapentin group than the control group (P < 0.05. The Glasgow coma scale score was better in the gabapentin group as compared to the control group (P < 0.05. The incidence of nausea and vomiting was lower in the gabapentin group as compared to the control group (P < 0.05. Conclusions: Pre-operative administration of gabapentin in patients undergoing craniotomy under general anaesthesia minimised the fluctuations in haemodynamics, reduced the requirements for sevoflurane and fentanyl, decreased intracranial pressure and improved the outcomes. There were some side effects associated with gabapentin such as hypotension and bradycardia.

  7. A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks.

    Science.gov (United States)

    Chang, Anne Lynn S; Alora-Palli, Maria; Lima, Xinaida T; Chang, Tiffany C; Cheng, Carol; Chung, Connie M; Amir, Omar; Kimball, Alexa B

    2012-03-01

    Papulopustular acne rosacea is a chronic inflammatory condition which can be difficult to treat. Many patients are unwilling to use systemic medications, and single topical agents alone may not address all the symptoms of rosacea. A combination topical clindamycin phosphate 1.2% and tretinoin 0.025% gel is efficacious for acne vulgaris, and may be helpful for rosacea, since acne vulgaris and rosacea shares many similar clinical and histologic features. To assess the preliminary efficacy and safety of a combination gel consisting of clindamycin phosphate 1.2% and tretinoin 0.025% on papulopustular rosacea after 12 weeks of usage. Randomized, double-blind, placebo controlled two site study of 79 participants with moderate to severe papulopustular acne rosacea using both physician and subjects' validated assessment tools. Primary endpoint consisted of statistically significant reduction in absolute papule or pustule count after 12 weeks of usage. There was no significant difference in papule/pustule count between placebo and treated groups after 12 weeks (P=0.10). However, there was nearly significant improvement in physicians' assessments of the telangiectasia component of rosacea (P=0.06) and erythematotelangiectatic rosacea subtype (P=0.05) in treated versus placebo group after 12 weeks. The only significant adverse event different was facial scaling, which was significantly increased in treated group (P=0.01), but this did not result in discontinuation of study drug. A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025% may improve the telangiectatic component of rosacea and appears to better treat the erythemotelangiectatic subtype of rosacea rather than papulopustular subtype. Our preliminary study suggests that future studies with much larger sample size might confirm our findings.

  8. Accuracy of a combined heart rate and motion sensor for assessing energy expenditure in free-living adults during a double-blind crossover caffeine trial using doubly labeled water as the reference method.

    Science.gov (United States)

    Silva, A M; Santos, D A; Matias, C N; Júdice, P B; Magalhães, J P; Ekelund, U; Sardinha, L B

    2015-01-01

    A combined heart rate (HR) and motion sensor (Actiheart) has been proposed as an accurate method for assessing total energy expenditure (TEE) and physical activity energy expenditure (PAEE). However, the extent to which factors such as caffeine may affect the accuracy by which the estimated HR-related PAEE contribution will affect TEE and PAEE estimates is unknown. Therefore, we examined the validity of Actiheart in estimating TEE and PAEE in free-living adults under a caffeine trial compared with doubly labeled water (DLW) as reference criterion. Using a double-blind crossover trial (Clinicaltrials.gov ID: #NCT01477294) with two conditions (4-day each with a 3-day-washout period), randomly ordered as caffeine (5 mg/kg per day) and placebo (malt-dextrine) intake, TEE was measured by DLW in 17 physically active men (20-38 years) who were non-caffeine users. In each condition, resting energy expenditure (REE) was assessed by indirect calorimetry and PAEE was calculated as (TEE-(REE+0.1 TEE)). Simultaneously, PAEE and TEE were estimated by Actiheart using an individual calibration (ACC+HRstep). Under caffeine, ACC+HRstep explained 76 and 64% of TEE and PAEE from DLW, respectively; corresponding results for the placebo condition were 82 and 66%. No mean bias was found between ACC+HRstep and DLW for TEE (caffeine:-468 kJ per day; placebo:-407 kJ per day), although PAEE was slightly underestimated (caffeine:-856 kJ per day; placebo:-1147 kJ per day). Similar limits of agreement were observed in both conditions ranging from -2066 to 3002 and from -3488 to 1776 kJ per day for TEE and PAEE, respectively. Regardless of caffeine intake, the combined HR and motion sensor is valid for estimating free-living energy expenditure in a group of healthy men but is less accurate for an individual assessment.

  9. A randomised, double-blind, placebo-controlled study to assess the safety and efficacy of methoxyflurane for procedural pain of a bone marrow biopsy.

    Science.gov (United States)

    Spruyt, Odette; Westerman, David; Milner, Alvin; Bressel, Mathias; Wein, Simon

    2014-12-01

    Pain during bone marrow biopsy (BMB) under local anaesthesia (LA) is reported in 70% of patients, of whom 35% rate the pain as severe. Pain is experienced during both the biopsy and the marrow aspiration. Many medical centres use conscious sedation involving benzodiazepines and/or opioids administered orally or intravenously for BMB analgesia. Methoxyflurane (MEOF) is self-administered by a handheld device (the Penthrox inhaler), which is licensed in Australia for the relief of pain associated with short surgical procedures. To evaluate the efficacy and safety of MEOF analgesia in patients with cancer undergoing BMB. Patients received LA plus either MEOF or placebo. The primary endpoint was worst pain intensity measured with the Numerical Rating Scale. Anxiety was assessed with the State Trait Anxiety Inventory (STAI-Y-1). Patients, operators and the research nurse rated global medication performance using a 5-point Likert scale. Forty-nine of the 50 patients randomised to MEOF and 48 of the 50 patients randomised to placebo effectively received the allocated intervention. Mean±SD worst pain overall was 4.90±2.07 in MEOF group and 6.0±2.24 in placebo group (p=0.011). Worst pain during the aspiration was 3.3±2.0 in MEOF group and 5.0±2.4 in placebo group (p<0.001). 49% of patients treated with MEOF rated the medication as very good or excellent compared with 16.5% of the patients treated with placebo (p=0.005). 20.4% of patients treated with MEOF had an adverse event (AE) compared with 4.2% in the placebo arm (p=0.028). All AEs were grade 1. MEOF was safe and performed better than placebo for analgesia in BMB procedures. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  10. Assessment

    National Research Council Canada - National Science Library

    Gehan Elassal; Mona Elsheikh; Abdel Gawad Abu Zeid

    2014-01-01

    .... Subjects and methods: 80 COPD patients were assessed using SCID for establishing psychiatric diagnosis, Beck depression inventory for assessment of the severity of depressive symptoms, Hamilton anxiety scale...

  11. A double-blind, randomized study to assess the validity of applied kinesiology (AK) as a diagnostic tool and as a nonlocal proximity effect.

    Science.gov (United States)

    Schwartz, Stephan A; Utts, Jessica; Spottiswoode, S James P; Shade, Christopher W; Tully, Lisa; Morris, William F; Nachman, Ginette

    2014-01-01

    Klinkoski and Leboeuf (1990), which considered 50 papers published between 1981 and 1987 by the International College of Applied Kinesiology, and the survey by Hall, Lewith, Brien, and Little (2008), using standard evaluation criteria [quality assessment tool for studies of diagnostic accuracy included in systematic reviews (QUADAS), Standards for Reporting of Diagnostic Studies (STARD), JADAD, and Consolidated Standards of Reporting Trials (CONSORT)], for research methodology, as well as six prior non-clinical studies by Radin (1984), Quintanar and Hill (1988), Braud (1989), Arnett et al. (1999), Ludtke (2001), and Kendler and Keating (2003), all together suggest the following: The research published by the Applied Kinesiology field itself is not to be relied upon, and in the experimental studies that do meet accepted standards of science, Applied Kinesiology has not demonstrated that it is a useful or reliable diagnostic tool upon which health decisions can be based. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. John Deakin: Double Exposures

    Directory of Open Access Journals (Sweden)

    Paul Rousseau

    2015-11-01

    Full Text Available In this series of short films made by Jonathan Law, the art historian James Boaden, and the curator of The John Deakin Archive, Paul Rousseau, discuss the double-exposure images made by the photographer John Deakin (1912-1972 in the 1950s and 1960s. The films ask you, firstly, to look closely at the images being discussed. Each one begins with a sustained and intense shot of a single image before opening up to a wide-ranging discussion about Deakin, double exposures, and photography.

  13. Double arch mirror study

    Science.gov (United States)

    Vukobratovich, D.; Hillman, D.

    1983-01-01

    The development of a method of mounting light weight glass mirrors for astronomical telescopes compatible with the goals of the Shuttle Infrared Telescope Facility (SIRTF) was investigated. A 20 in. diameter double arch lightweight mirror previously fabricated was modified to use a new mount configuration. This mount concept was developed and fabricated. The mounting concept of the double mounting mirror is outlined. The modifications made to the mirror, fabrication of the mirror mount, and room temperature testing of the mirror and mount and the extension of the mirror and mount concept to a full size (40 in. diameter) primary mirror for SIRTF are discussed.

  14. Double-Barred Galaxies

    OpenAIRE

    Erwin, Peter

    2009-01-01

    I present a brief review of what is known about double-barred galaxies, where a small ("inner") bar is nested inside a larger ("outer") bar; the review is focused primarily on their demographics and photometric properties. Roughly 20% of S0--Sb galaxies are double-barred; they may be rarer in later Hubble types. Inner bars are typically ~ 500 pc in radius (~ 12% the size of outer bars), but sizes range from ~ 100 pc to > 1 kpc. The structure of at least some inner bars appears very similar to...

  15. The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse.

    Science.gov (United States)

    Yarom, Noam; Zelig, Keren; Epstein, Joel B; Gorsky, Meir

    2017-06-01

    The aim of the study was to assess the efficacy of 2 different concentrations of minocycline mouthwashes on the symptoms of recurrent aphthous stomatitis (RAS). The 2-year study was designed as a randomized, double-blind, crossover study. Healthy patients with frequent RAS episodes received 2 sealed and computer-randomized marked kits containing minocycline mouthwashes (0.2% and 0.5% solution). The patients were asked to use 1 of the kits on the first episode of RAS, starting with the first onset of prodromal symptoms, until the symptoms resolved or up to a maximum of 10 days (whichever came first). The patients were asked to use their second kit during a subsequent episode. A total of 14 patients (8 males, 6 females) completed the 2 arms of the study. The mean intensity of pain was significantly lower when the 0.5% solution was used compared with the 0.2% solution (P = .027). The difference reached the level of statistical significance as soon as the end of the second day of use (P = .032). Only minor and temporary adverse reactions were documented. We found that 0.5% minocycline mouth rinse was more effective than the 0.2% concentration, which had been suggested by our group in previous studies for the management of RAS. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Randomised, double-blind, placebo-controlled studies on flurbiprofen 8.75 mg lozenges in patients with/without group A or C streptococcal throat infection, with an assessment of clinicians' prediction of 'strep throat'.

    Science.gov (United States)

    Shephard, A; Smith, G; Aspley, S; Schachtel, B P

    2015-01-01

    Diagnosing group A streptococcus (Strep A) throat infection by clinical examination is difficult, and misdiagnosis may lead to inappropriate antibiotic use. Most patients with sore throat seek symptom relief rather than antibiotics, therefore, therapies that relieve symptoms should be recommended to patients. We report two clinical trials on the efficacy and safety of flurbiprofen 8.75 mg lozenge in patients with and without streptococcal sore throat. The studies enrolled adults with moderate-to-severe throat symptoms (sore throat pain, difficulty swallowing and swollen throat) and a diagnosis of pharyngitis. The practitioner assessed the likelihood of Strep A infection based on historical and clinical findings. Patients were randomised to flurbiprofen 8.75 mg or placebo lozenges under double-blind conditions and reported the three throat symptoms at baseline and at regular intervals over 24 h. A total of 402 patients received study medication (n = 203 flurbiprofen, n = 199 placebo). Throat culture identified Strep A in 10.0% of patients and group C streptococcus (Strep C) in a further 14.0%. The practitioners' assessments correctly diagnosed Strep A in 11/40 cases (sensitivity 27.5%, and specificity 79.7%). A single flurbiprofen lozenge provided significantly greater relief than placebo for all three throat symptoms, lasting 3-4 h for patients with and without Strep A/C. Multiple doses of flurbiprofen lozenges over 24 h also led to symptom relief, although not statistically significant in the Strep A/C group. There were no serious adverse events. The results highlight the challenge of identifying Strep A based on clinical features. With the growing problem of antibiotic resistance, non-antibiotic treatments should be considered. As demonstrated here, flurbiprofen 8.75 mg lozenges are an effective therapeutic option, providing immediate and long-lasting symptom relief in patients with and without Strep A/C infection. © 2014 John Wiley & Sons Ltd.

  17. A double-blind, randomized trial, including frequent patient–physician contacts and Ramadan-focused advice, assessing vildagliptin and gliclazide in patients with type 2 diabetes fasting during Ramadan: the STEADFAST study

    Directory of Open Access Journals (Sweden)

    Hassanein M

    2014-05-01

    Full Text Available Mohamed Hassanein,1 Khalifa Abdallah,2 Anja Schweizer31Betsi Cadwaladr University Health Board, Wales, United Kingdom; 2Clinical Research Center, Alexandria University Hospital, Alexandria, Egypt; 3Global Medical Affairs, Novartis Pharma AG, Basel, SwitzerlandBackground: Several observational studies were conducted with vildagliptin in patients with type 2 diabetes mellitus (T2DM fasting during Ramadan, showing significantly lower incidences of hypoglycemia with vildagliptin versus sulfonylureas, including gliclazide. It was of interest to complement the existing real-life evidence with data from a randomized, double-blind, clinical trial.Clinical Trials Identifier: NCT01758380.Methods: This multiregional, double-blind study randomized 557 patients with T2DM (mean glycated hemoglobin [HbA1c], 6.9%, previously treated with metformin and any sulfonylurea to receive either vildagliptin (50 mg twice daily or gliclazide plus metformin. The study included four office visits (three pre-Ramadan and multiple telephone contacts, as well as Ramadan-focused advice. Hypoglycemic events were assessed during Ramadan; HbA1c and weight were analyzed before and after Ramadan.Results: The proportion of patients reporting confirmed (<3.9 mmol/L and/or severe hypoglycemic events during Ramadan was 3.0% with vildagliptin and 7.0% with gliclazide (P=0.039; one-sided test, and this was 6.0% and 8.7%, respectively, for any hypoglycemic events (P=0.173. The adjusted mean change pre- to post-Ramadan in HbA1c was 0.05%±0.04% with vildagliptin and -0.03%±0.04% with gliclazide, from baselines of 6.84% and 6.79%, respectively (P=0.165. In both groups, the adjusted mean decrease in weight was -1.1±0.2 kg (P=0.987. Overall safety was similar between the treatments.Conclusion: In line with the results from previous observational studies, vildagliptin was shown in this interventional study to be an effective, safe, and well-tolerated treatment in patients with T2DM fasting

  18. A double-blind, randomized trial, including frequent patient-physician contacts and Ramadan-focused advice, assessing vildagliptin and gliclazide in patients with type 2 diabetes fasting during Ramadan: the STEADFAST study.

    Science.gov (United States)

    Hassanein, Mohamed; Abdallah, Khalifa; Schweizer, Anja

    2014-01-01

    Several observational studies were conducted with vildagliptin in patients with type 2 diabetes mellitus (T2DM) fasting during Ramadan, showing significantly lower incidences of hypoglycemia with vildagliptin versus sulfonylureas, including gliclazide. It was of interest to complement the existing real-life evidence with data from a randomized, double-blind, clinical trial. NCT01758380. This multiregional, double-blind study randomized 557 patients with T2DM (mean glycated hemoglobin [HbA1c], 6.9%), previously treated with metformin and any sulfonylurea to receive either vildagliptin (50 mg twice daily) or gliclazide plus metformin. The study included four office visits (three pre-Ramadan) and multiple telephone contacts, as well as Ramadan-focused advice. Hypoglycemic events were assessed during Ramadan; HbA(1c) and weight were analyzed before and after Ramadan. The proportion of patients reporting confirmed (Ramadan was 3.0% with vildagliptin and 7.0% with gliclazide (P=0.039; one-sided test), and this was 6.0% and 8.7%, respectively, for any hypoglycemic events (P=0.173). The adjusted mean change pre- to post-Ramadan in HbA(1c) was 0.05%±0.04% with vildagliptin and -0.03%±0.04% with gliclazide, from baselines of 6.84% and 6.79%, respectively (P=0.165). In both groups, the adjusted mean decrease in weight was -1.1±0.2 kg (P=0.987). Overall safety was similar between the treatments. In line with the results from previous observational studies, vildagliptin was shown in this interventional study to be an effective, safe, and well-tolerated treatment in patients with T2DM fasting during Ramadan, with a consistently low incidence of hypoglycemia across studies, accompanied by good glycemic and weight control. In contrast, gliclazide showed a lower incidence of hypoglycemia in the present interventional than the previous observational studies. This is suggested to be linked to the specific circumstances of this study, including frequent patient-physician contacts

  19. A double-blind, randomized trial, including frequent patient–physician contacts and Ramadan-focused advice, assessing vildagliptin and gliclazide in patients with type 2 diabetes fasting during Ramadan: the STEADFAST study

    Science.gov (United States)

    Hassanein, Mohamed; Abdallah, Khalifa; Schweizer, Anja

    2014-01-01

    Background Several observational studies were conducted with vildagliptin in patients with type 2 diabetes mellitus (T2DM) fasting during Ramadan, showing significantly lower incidences of hypoglycemia with vildagliptin versus sulfonylureas, including gliclazide. It was of interest to complement the existing real-life evidence with data from a randomized, double-blind, clinical trial. Clinical Trials Identifier NCT01758380. Methods This multiregional, double-blind study randomized 557 patients with T2DM (mean glycated hemoglobin [HbA1c], 6.9%), previously treated with metformin and any sulfonylurea to receive either vildagliptin (50 mg twice daily) or gliclazide plus metformin. The study included four office visits (three pre-Ramadan) and multiple telephone contacts, as well as Ramadan-focused advice. Hypoglycemic events were assessed during Ramadan; HbA1c and weight were analyzed before and after Ramadan. Results The proportion of patients reporting confirmed (Ramadan was 3.0% with vildagliptin and 7.0% with gliclazide (P=0.039; one-sided test), and this was 6.0% and 8.7%, respectively, for any hypoglycemic events (P=0.173). The adjusted mean change pre- to post-Ramadan in HbA1c was 0.05%±0.04% with vildagliptin and −0.03%±0.04% with gliclazide, from baselines of 6.84% and 6.79%, respectively (P=0.165). In both groups, the adjusted mean decrease in weight was −1.1±0.2 kg (P=0.987). Overall safety was similar between the treatments. Conclusion In line with the results from previous observational studies, vildagliptin was shown in this interventional study to be an effective, safe, and well-tolerated treatment in patients with T2DM fasting during Ramadan, with a consistently low incidence of hypoglycemia across studies, accompanied by good glycemic and weight control. In contrast, gliclazide showed a lower incidence of hypoglycemia in the present interventional than the previous observational studies. This is suggested to be linked to the specific

  20. Aristotle and Double Effect

    DEFF Research Database (Denmark)

    Di Nucci, Ezio

    2014-01-01

    There are some interesting similarities between Aristotle’s ‘mixed actions’ in Book III of the Nicomachean Ethics and the actions often thought to be justifiable with the Doctrine of Double Effect. Here I analyse these similarities by comparing Aristotle’s examples of mixed actions with standard ...

  1. Neutrinoless double beta decay

    Indian Academy of Sciences (India)

    2015-11-27

    Nov 27, 2015 ... Abstract. The physics potential of neutrinoless double beta decay is discussed. Furthermore, experimental considerations as well as the current status of experiments are presented. Finally, an outlook towards the future, work on nuclear matrix elements and alternative processes is given.

  2. Double-Glazing Interferometry

    Science.gov (United States)

    Toal, Vincent; Mihaylova, Emilia M.

    2009-01-01

    This note describes how white light interference fringes can be seen by observing the Moon through a double-glazed window. White light interferometric fringes are normally observed only in a well-aligned interferometer whose optical path difference is less than the coherence length of the light source, which is approximately one micrometer for…

  3. Double beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Bryman, D.; Picciotto, C.

    1978-01-01

    The problem of double beta decay is reviewed with emphasis on its relevance to lepton number conservation. Recently, the ratio of the double beta-decay half-lives of /sup 128/Te and /sup 130/Te has been measured in a geological experiment and a limit for the ratio of the neutrinoless rate to the total rate for /sup 82/Se decay has been obtained from a direct-detection experiment. For the first time, these results show conclusively that double beta decay is not primarily a lepton-number-violating neutrinoless process. However, they also do not agree with calculations which assume that only lepton-number-conserving two-neutrino double beta decay occurs. The conclusion that lepton number conservation is violated is suggested by limited experimental information. By considering contributions to the total rate from both the two-neutrino and the neutrinoless channels, we obtain data which are consistent with a lepton nonconservation parameter of order eta=3.5 x 10/sup -5/. Roughly the same value of eta is obtained by assuming that the decay occurs either via lepton emission from two nucleons or via emission from a resonance in the nucleus.

  4. Design for Double Rainbow

    Science.gov (United States)

    Thomas, Lisa Carlucci

    2011-01-01

    Rare is the inspirational, spontaneous, transformative moment shared among 20 million people. In the summer of 2010, people around the world were moved by the sighting of a double rainbow--almost a triple rainbow--"all the way across the sky" in Yosemite National Park. Caught on video and posted to by YouTube by Paul Vasquez in January 2010, the…

  5. Generalizing double graphs

    Directory of Open Access Journals (Sweden)

    Zagaglia Salvi, Norma

    2007-10-01

    Full Text Available In this paper we study the graphs which are direct product of a simple graph G with the graphs obtained by the complete graph Kk adding a loop to each vertex; thus these graphs turn out to be a generalization of the double graphs.

  6. Hybrid Double Quantum Dots

    DEFF Research Database (Denmark)

    Sherman, D.; Yodh, J. S.; Albrecht, S. M.

    2016-01-01

    Epitaxial semiconductor-superconductor hybrid materials are an excellent basis for studying mesoscopic and topological superconductivity, as the semiconductor inherits a hard superconducting gap while retaining tunable carrier density. Here, we investigate double-quantum-dot devices made from InA...... that the individual dots host weakly hybridized Majorana modes....

  7. Initial and delayed stress phase imaging in a single-injection double-acquisition SPECT. The potential value of early {sup 99m}Tc-MIBI redistribution in assessment of myocardial perfusion reversibility in patients with coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Beiki, D. [Research Inst. for Nuclear Medicine, Tehran Univ. of Medical Sciences, Tehran (Iran); Dept. of Nuclear Pharmacy, Tehran Univ. of Medical Sciences, Tehran (Iran); Fallahi, B.; Fard-Esfahani, A.; Eftekhari, M. [Research Inst. for Nuclear Medicine, Tehran Univ. of Medical Sciences, Tehran (Iran); Mohseni, Z.; Khalaj, A. [Dept. of Nuclear Pharmacy, Tehran Univ. of Medical Sciences, Tehran (Iran)

    2010-07-01

    Some studies reported that {sup 99m}Tc-MIBI may redistribute in ischaemic myocardium and this phenomenon may have potential role for better assessment of viability by delayed {sup 99m}Tc-MIBI imaging. Some studies also suggested that infusion of low dose dobutamine during delayed imaging may enhance the value of {sup 99m}Tc-MIBI imaging for evaluation of viability. The aim of this study is to determine whether the observed changes of perfusion defects on delayed images are caused by early radiotracer redistribution or as a result of reversal partial volume effect secondary to inotropic stimulation. Patients, methods: 89 patients with angiographically proven coronary artery disease (CAD) were enrolled in this randomized clinical trial study. In all cases, gated-SPECT images were obtained 60 minutes after stress with dipyridamole injection. Subsequently the patients were randomly allocated in two groups and the second imaging was performed at 120{sup th} minute during low dose dobutamine (dobutamine group; 45 cases) or placebo infusion (placebo group; 44 cases). Difference between summed stress score of the first (SSS{sub 1}) and second (SSS{sub 2}) stress images ({delta}SSS) was considered as a marker of reversibility in single-injection double-acquisition (SIDA) protocol. Also summed difference score (SDS) was recorded as a marker of reversibility in standard stress/rest, double-injection double-acquisition (DIDA) protocol. {delta}SSS of the two studied groups were compared. Also the correlation and agreement between {delta}SSS and SDS were analyzed. Results: A significant difference was found between SSS{sub 1} (median 15, range 0-48) and SSS{sub 2} (median 11, range 0-42) in total patients (p < 0.0001). A significant correlation was noted between {delta}SSS and SDS in dobutamine group (r = 0.58, p = 0.002) as well as in placebo group (r = 0.57, p < 0.0001). Considering DIDA protocol as a standard reference method, the influence of dobutamine infusion was not

  8. Improved Resin–Zirconia Bonding by Room Temperature Hydrofluoric Acid Etching

    Directory of Open Access Journals (Sweden)

    Mun-Hwan Lee

    2015-03-01

    Full Text Available This in vitro study was conducted to evaluate the shear bond strength of “non-self-adhesive” resin to dental zirconia etched with hydrofluoric acid (HF at room temperature and to compare it to that of air-abraded zirconia. Sintered zirconia plates were air-abraded (control or etched with 10%, 20%, or 30% HF for either 5 or 30 min. After cleaning, the surfaces were characterized using various analytical techniques. Three resin cylinders (Duo-Link were bonded to each treated plate. All bonded specimens were stored in water at 37 °C for 24 h, and then half of them were additionally thermocycled 5000 times prior to the shear bond-strength tests (n = 12. The formation of micro- and nano-porosities on the etched surfaces increased with increasing concentration and application time of the HF solution. The surface wettability of zirconia also increased with increasing surface roughness. Higher concentrations and longer application times of the HF solution produced higher bond-strength values. Infiltration of the resin into the micro- and nano-porosities was observed by scanning electron microscopy. This in vitro study suggests that HF slowly etches zirconia ceramic surfaces at room temperature, thereby improving the resin–zirconia bond strength by the formation of retentive sites.

  9. In vivo comparison between laser-treated and grit blasted/acid etched titanium

    NARCIS (Netherlands)

    Prodanov, L.; Lamers, E.; Wolke, J.G.; Huiberts, R.; Jansen, J.A.; Walboomers, X.F.

    2014-01-01

    OBJECTIVE: Laser profiling of titanium has been of considerable interest in the field of oral implantology. However, very few pre-clinical and clinical studies have been performed with laser-treated implants, especially focusing on isotropic roughness topography. The aim of the study was to compare

  10. Effect of sulfuric acid etching of polyetheretherketone on the shear bond strength to resin cements.

    Science.gov (United States)

    Sproesser, Oliver; Schmidlin, Patrick R; Uhrenbacher, Julia; Roos, Malgorzata; Gernet, Wolfgang; Stawarczyk, Bogna

    2014-10-01

    To examine the influence of etching duration on the bond strength of PEEK substrate in combination with different resin composite cements. In total, 448 PEEK specimens were fabricated, etched with sulfuric acid for 5, 15, 30, 60, 90, 120, and 300 s and then luted with two conventional resin cements (RelyX ARC and Variolink II) and one self-adhesive resin cement (Clearfil SA Cement) (n = 18/subgroup). Non-etched specimens served as the control group. Specimens were stored in distilled water for 28 days at 37°C and shear bond strengths were measured. Data were analyzed nonparametrically using Kruskal-Wallis-H (p cements. The optimal etching duration varied with the type of resin composite: 60 s for RelyX ARC (15.3 ± 7.2 MPa), 90 s for Variolink II (15.2 ± 7.2 MPa), and 120 s for Clearfil SA Cement (6.4 ± 5.9 MPa). Regardless of etching duration, however, the self-etching resin composite cement showed significantly lower shear bond strength values when compared to groups luted with the conventional resin composites. Although sulfuric acid seems to be suitable and effective for PEEK surface pre-treatment, further investigations are required to examine the effect of other adhesive systems and cements.

  11. Color Stability of Enamel following Different Acid Etching and Color Exposure Times

    Directory of Open Access Journals (Sweden)

    Arezoo Jahanbin

    2014-06-01

    Full Text Available Background and aims. The aim of this study was to evaluate the effect of different etching times on enamel color stability after immediate versus delayed exposure to colored artificial saliva (CAS. Materials and methods. Human first premolars were divided into five groups of twenty. A colorimeter was used according to the CIE system on the mid-buccal and mid-lingual surfaces to evaluate initial tooth color. Samples in group A remained unetched. In groups B to E, buccal and lingual surfaces were initially etched with phosphoric acid for 15 and 60 seconds, respectively. Then, the samples in groups A and C were immersed in colored artificial saliva (cola+saliva. In group B, the teeth were immersed in simple artificial saliva (AS. Samples in groups D and E were immersed in AS for 24 and 72 hours, respectively before being immersed in colored AS. The teeth were immersed for one month in each solution before color measurement. During the test period, the teeth were retrieved from the staining solution and stored in AS for five minutes. This was repeated 60 times. Color changes of buccal and lingual surfaces were calculated. Kruskal-Wallis and Wilcoxon tests were used for statistical analysis (α ≤ 0.05. Results. There were no significant differences between the groups in term of ΔE of buccal (P = 0.148 and lingual surfaces (P = 0.73. Conclusion. Extended time of etching did not result in significant enamel color change. Immediate and delayed exposure of etched enamel to staining solutions did not result in clinically detectable tooth color changes.

  12. Examples of Optical Assessment of Surface Cleanliness of Genesis Samples

    Science.gov (United States)

    Rodriquez, Melissa C.; Allton, J. H.; Burkett, P. J.; Gonzalez, C. P.

    2013-01-01

    Optical microscope assessment of Genesis solar wind collector surfaces is a coordinated part of the effort to obtain an assessed clean subset of flown wafer material for the scientific community. Microscopic survey is typically done at 50X magnification at selected approximately 1 square millimeter areas on the fragment surface. This survey is performed each time a principle investigator (PI) returns a sample to JSC for documentation as part of the established cleaning plan. The cleaning plan encompasses sample handling and analysis by Genesis science team members, and optical survey is done at each step in the process. Sample surface cleaning is performed at JSC (ultrapure water [1] and UV ozone cleaning [2]) and experimentally by other science team members (acid etch [3], acetate replica peels [4], CO2 snow [5], etc.). The documentation of each cleaning method can potentially be assessed with optical observation utilizing Image Pro Plus software [6]. Differences in particle counts can be studied and discussed within analysis groups. Approximately 25 samples have been identified as part of the cleaning matrix effort to date.

  13. Applications of Diamonded Double Negation

    OpenAIRE

    Yli-Jyrä, Anssi

    2008-01-01

    Nested complementation plays an important role in expressing counter- i.e. star-free and first-order definable languages and their hierarchies. In addition, methods that compile phonological rules into finite-state networks use double-nested complementation or “double negation”. This paper reviews how the double-nested complementation extends to a relatively new operation, generalized restriction (GR), coined by the author (Yli-Jyrä and Koskenniemi 2004). This operation encapsulates a double-...

  14. Double Cortex Syndrome

    OpenAIRE

    J Gordon Millichap

    1999-01-01

    The incidence of mutations in the X-linked gene doublecortin in patients with “double cortex” syndrome (DC; also called subcortical band heterotopia or laminar heterotopia) and familial DC with lissencephaly was investigated in a cohort of 8 pedigrees and 47 sporadic patients with DC examined at the Division of Neurogenics, Beth Israel Deaconess Medical Center, Boston, and multiple centers in the US and abroad.

  15. Algebra of Majorana doubling.

    Science.gov (United States)

    Lee, Jaehoon; Wilczek, Frank

    2013-11-27

    Motivated by the problem of identifying Majorana mode operators at junctions, we analyze a basic algebraic structure leading to a doubled spectrum. For general (nonlinear) interactions the emergent mode creation operator is highly nonlinear in the original effective mode operators, and therefore also in the underlying electron creation and destruction operators. This phenomenon could open up new possibilities for controlled dynamical manipulation of the modes. We briefly compare and contrast related issues in the Pfaffian quantum Hall state.

  16. Double-O Habitat Management Plan: Malheur National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Double-0 Plan is a step-down plan of the 1985 Refuge Master Plan and Environmental Assessment. The purpose of this plan is to guide the management, protection,...

  17. A randomized, double-blind, placebo-controlled, cross-over pilot study to assess the effects of long-term opioid drug consumption and subsequent abstinence in chronic noncancer pain patients receiving controlled-release morphine.

    Science.gov (United States)

    Cowan, David T; Wilson-Barnett, Jenifer; Griffiths, Peter; Vaughan, David J A; Gondhia, Anjalee; Allan, Laurie G

    2005-01-01

    The long-term use of strong opioid analgesics among chronic noncancer pain (CNCP) patients remains controversial because of concerns over problematic drug use. However, previous surveys suggest that this is not necessarily the case. Therefore, we designed a controlled study to generate evidence in support of these findings. Ten CNCP patients attending the pain clinic in a district general hospital had been taking an average daily dose of 40 mg controlled-release morphine sulphate (mean 40, range 10-90, SD 21 mg), for an average of 2 years (mean 2.175, range 2-2.25, SD 0.2 years). Randomized, double-blind, placebo controlled cross-over study. The study was based on the premise that abrupt cessation of opioid drugs is most likely to highlight problematic use and the consequent inability to stop using opioids. Morphine was substituted with placebo for 60-hour periods to compare the effects of abstinence with those of continued use. Assessment of morphine cessation and abstinence effects was through direct observation, physiological measurements, questionnaire responses, and Brief Pain Inventory scores. Following cessation and abstinence, there were no indications of psychological dependence or drug craving, but there was evidence of the detrimental effects of pain intensity on activity, mood, relationships, sleep, and enjoyment of life. Three patients (30%) reported opioid drug withdrawal symptoms. Pharmacokinetic data demonstrated compliance with abstinence by all patients. The results suggest the existence of a group of CNCP patients whose long-term opioid consumption can be beneficial and remain moderate without them suffering from the consequences of problematic opioid drug use.

  18. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects1234

    Science.gov (United States)

    Xia, Yiming; Hill, Kristina E; Li, Ping; Xu, Jiayuan; Zhou, Dingyou; Motley, Amy K; Wang, Li; Byrne, Daniel W; Burk, Raymond F

    2010-01-01

    Background: The intake of selenium needed for optimal health has not been established. Selenoproteins perform the functions of selenium, and the selenium intake needed for their full expression is not known. Objective: This study sought to determine the intake of selenium required to optimize plasma selenoprotein P (SEPP1) and to compare SEPP1 with other plasma selenium biomarkers. Design: A 40-wk placebo-controlled, double-blind study of selenium repletion was carried out in 98 healthy Chinese subjects who had a daily dietary selenium intake of 14 mu g. Fourteen subjects each were assigned randomly to daily dose groups of 0, 21, 35, 55, 79, 102, and 125 mu g Se as l-selenomethionine. Plasma glutathione peroxidase (GPX) activity, SEPP1, and selenium were measured. A biomarker was considered to be optimized when its value was not different from the mean value of the subjects receiving larger supplements. Results: The SEPP1 concentration was optimized at 40 wk by the 35- mu g supplement, which indicated that 49 mu g/d could optimize it. GPX activity was optimized by 21 mu g (total ingestion: 35 mu g/d). The selenium concentration showed no tendency to become optimized. Conclusions: The present results indicate that SEPP1 concentration is the best plasma biomarker studied for assessing optimal expression of all selenoproteins, because its optimization required a larger intake of selenium than did GPX activity. On the basis of the selenium intake needed for SEPP1 optimization with adjustments for body weight and individual variation, ap 75 mu g Se/d as selenomethionine is postulated to allow full expression of selenoproteins in US residents. This trial was registered at clinicaltrials.gov as NCT00428649. PMID:20573787

  19. Results of double contrast enema

    Energy Technology Data Exchange (ETDEWEB)

    Czembirek, H.; Sommer, G.; Wittich, G.; Tscholakoff, D.; Salomonowitz, E.

    1983-07-01

    Experiences and results of double contrast enemas are reported. The accuracy of double contrast enemas is proved by 500 consecutive investigations. Correlation of endoscopic and roentgenologic investigations showed, that the double contrast enema is a reliable method concerning the detection of polyps, carcinomas and inflammatory colon diseases. Advantages and disadvantages of roentgenology and endoscopy of the colon are discussed.

  20. A randomized, double blind, cross-over, placebo-controlled clinical trial to assess the effects of Candesartan on the insulin sensitivity on non diabetic, non hypertense subjects with dysglyce mia and abdominal obesity. "ARAMIA"

    Directory of Open Access Journals (Sweden)

    Rueda-Clausen Christian F

    2006-09-01

    Full Text Available Abstract Background The raising prevalence of type-2 diabetes mellitus and obesity has been recognized as a major problem for public health, affecting both developed and developing countries. Impaired fasting plasma glucose has been previously associated with endothelial dysfunction, higher levels of inflammatory markers and increased risk of developing insulin resistance and cardiovascular events. Besides life-style changes, the blockade of the renin-angiotensin system has been proposed as a useful alternative intervention to improve insulin resistance and decrease the number of new type-2 diabetes cases. The aim of this clinical trial is to study the effect of the treatment with Candesartan, an angiotensin II receptor antagonist, on the insulin resistance, the plasma levels of adipoquines, oxidative stress and prothrombotic markers, in a group of non diabetic, non hypertensive, dysglycemic and obese subjects. Methods and design A randomized, double blind, cross-over, placebo-controlled, clinical trial was designed to assess the effects of Candesartan (up to 32 mg/day during 6 months on the Homeostasis Model Assessment (HOMA index, lipid profile, protrombotic state, oxidative stress and plasma levels of inflammatory markers. The participants will be recruited in the "Fundación Cardiovascular de Colombia". Subjects who fullfil selection criteria will receive permanent educational, nutritional and exercise support during their participation in the study. After a 15 days-run-in period with placebo and life-style recommendations, the patients who have a treatment compliance equal or greater than 80% will be randomlly assigned to one of the treatment groups. Group A will receive Candesartan during 6 months and placebo during 6 months. Group B will receive placebo during the first 6 months, and then, Candesartan during the last 6 months. Control visits will be programed monthly and all parameters of interest will be evaluated every 6 months

  1. Ac-induced disruption of the doubleDs structure in tomato

    NARCIS (Netherlands)

    Rommens, Caius M.T.; Biezen, Erik A. van der; Ouwerkerk, Pieter B.F.; Nijkamp, H. John J.; Hille, Jacques

    1991-01-01

    The maize doubleDs element is stably maintained in the tomato genome. Upon the subsequent introduction of Ac into a plant containing doubleDs, disruption of the doubleDs structure and DNA rearrangements at the site of the doubleDs element were observed. No indications were obtained for excision of

  2. The Double Star mission

    Directory of Open Access Journals (Sweden)

    Liu

    2005-11-01

    Full Text Available The Double Star Programme (DSP was first proposed by China in March, 1997 at the Fragrant Hill Workshop on Space Science, Beijing, organized by the Chinese Academy of Science. It is the first mission in collaboration between China and ESA. The mission is made of two spacecraft to investigate the magnetospheric global processes and their response to the interplanetary disturbances in conjunction with the Cluster mission. The first spacecraft, TC-1 (Tan Ce means "Explorer", was launched on 29 December 2003, and the second one, TC-2, on 25 July 2004 on board two Chinese Long March 2C rockets. TC-1 was injected in an equatorial orbit of 570x79000 km altitude with a 28° inclination and TC-2 in a polar orbit of 560x38000 km altitude. The orbits have been designed to complement the Cluster mission by maximizing the time when both Cluster and Double Star are in the same scientific regions. The two missions allow simultaneous observations of the Earth magnetosphere from six points in space. To facilitate the comparison of data, half of the Double Star payload is made of spare or duplicates of the Cluster instruments; the other half is made of Chinese instruments. The science operations are coordinated by the Chinese DSP Scientific Operations Centre (DSOC in Beijing and the European Payload Operations Service (EPOS at RAL, UK. The spacecraft and ground segment operations are performed by the DSP Operations and Management Centre (DOMC and DSOC in China, using three ground station, in Beijing, Shanghai and Villafranca.

  3. Layered double hydroxides

    DEFF Research Database (Denmark)

    López Rayo, Sandra; Imran, Ahmad; Hansen, Hans Chr. Bruun

    2017-01-01

    A novel zinc (Zn) fertilizer concept based on Zn doped layered double hydroxides (Zn-doped Mg-Fe-LDHs) has been investigated. Zn-doped Mg-Fe-LDHs were synthetized, their chemical composition was analyzed and their nutrient release was studied in buffered solutions with different pH values. Uptake...... the long-term Zn release capacity of LDHs complying with a release-on-demand behavior and serves as proof-of-concept that Zn-doped Mg-Fe-LDHs can be used as Zn fertilizers....

  4. Double conjugate laser amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Chandra, S.; Daunt, G.H.

    1991-01-29

    This paper describes a double conjugate laser amplifier system for producing a stable output laser beam in line with a laser oscillator input beam. It comprises: a laser oscillator which produces a low energy oscillator laser beam therefrom directly along a laser beam axis of the system; an amplification means comprised of double conjugate laser amplifiers further comprised of a first and a second singly phase conjugate amplifiers laterally opposite each other about the laser beam axis; polarizers with one of the polarizers positioned between each of the first and second singly phase conjugate amplifiers on the laser beam axis; Pockels cells with on of the Pockels cells positioned on the laser beam axis immediately prior to one of the polarizers; and a means for selectively switching the amplifier means comprised of applying a half-wave voltage at each of the Pockels cells to provide a polarization rotation of the input beam through 90{degrees} for routing of the oscillator laser beam directly through or reflected off the polarizes as an input beam to the amplification means wherein the amplification means amplifies the input beam twice in each of the first and second singly phase conjugate amplifiers and reflects the amplified laser beam off the polarizers as an amplified laser output beam in exactly the same direction as the input laser beam.

  5. A double-blind comparison of two creams containing urea as the active ingredient. Assessment of efficacy and side-effects by non-invasive techniques and a clinical scoring scheme.

    Science.gov (United States)

    Serup, J

    1992-01-01

    From a group of 72 healthy individuals, 47 with evidence of dry skin according to measurements by non-invasive techniques were enrolled for a 3-week study with double-blind and randomized treatment of one forearm, using either 3% urea cream (HTH lotion 'light') or 10% urea cream (HTH lotion 'Original'). The contralateral forearm served as an untreated control. Two volunteers had to be excluded because measurements of skin surface lipids gave evidence of vehicle components on the skin surface at the time of final evaluations. Evaluations took place not less than 12 h after the last application. According to questionnaire replies, the two creams were equally effective. This was confirmed by "blind" evaluation of the skin hydration state by a dermatologist, measurements of electrical capacitance and conductance indicating epidermal and skin surface hydration, and by D-Squame tape assessments including optical transmission of tapes with stratum corneum and scales from adhering skin, as well as visual scoring of the tapes. The methods showed a high degree of correlation, i.a. a definite relation between increase in electrical hydration parameters, reduced scaling according to the D-Squame tape evaluations, and clinical improvement of dryness. In skin treated with 10% urea cream the transepidermal water loss (TEWL) decreased, indicating an improved water barrier function. Skin colour measurement according to the CIE colour system showed that skin treated with the 3% urea cream turned in the direction of yellow, and there was generally a tendency for the brightness to decrease. Thus, the 3% urea cream gave the skin a more golden colour. There was no change in redness with any of the creams. Neither data from the questionnaire, the clinical examination, nor results of TEWL and colour measurements indicated any local irritant effect of urea causing water barrier damage or inflammation. In conclusion, the 3% and 10% urea creams were both found efficient, resulting in

  6. PREPARATION OF LAYERED DOUBLE HYDROXIDES

    National Research Council Canada - National Science Library

    OGAWA, MAKOTO; INOMATA, KAZUYA

    2011-01-01

    Layered double hydroxides (LDHs) are class of materials with useful properties associated with their anion exchange abilities for a wide range of applications including bio and environmental problems...

  7. Colored Flag by Double Refraction.

    Science.gov (United States)

    Reid, Bill

    1994-01-01

    Describes various demonstrations that illustrate double refraction and rotation of the plane of polarization in stressed, transparent plastics, with the consequent production of colored designs. (ZWH)

  8. Double-Skin Facade

    DEFF Research Database (Denmark)

    Kalyanova, Olena

    Double-Skin Facades (DSF) are gaining popularity that, in fact, appears to be independent from sturdy critics of the concept in the past years. DSF buildings are being built in Europe and worldwide, DSF concept is being taught at schools of architecture and fully glazed office buildings are being...... favored by companies and their employees. To bring the reduction of energy use in these buildings application of suitable tools and methods is necessary to achieve successful design solutions. Earlier work on the topic of DSF modelling was examined from various publications. As a result, the main...... difficulties experienced by scientists when attempting to model DSF thermal and energy performance were examined. In addition, the lack of experimental studies and empirical validation of models was realized, many numerical models have not been empirically validated and most of them require an expert knowledge...

  9. Layered double hydroxides

    DEFF Research Database (Denmark)

    López Rayo, Sandra; Imran, Ahmad; Hansen, Hans Chr. Bruun

    2017-01-01

    A novel zinc (Zn) fertilizer concept based on Zn doped layered double hydroxides (Zn-doped Mg-Fe-LDHs) has been investigated. Zn-doped Mg-Fe-LDHs were synthetized, their chemical composition was analyzed and their nutrient release was studied in buffered solutions with different pH values. Uptake...... of Zn by barley (Hordeum vulgare cv. Antonia) was evaluated in short- (8 weeks), medium- (11 weeks) and long-term (28 weeks) experiments in quartz sand and in a calcareous soil enriched with Zn-doped Mg-Fe-LDHs. The Zn release rate of the Zn-doped Mg-Fe-LDHs was described by a first-order kinetics...

  10. Dual double field theory

    Energy Technology Data Exchange (ETDEWEB)

    Bergshoeff, Eric A. [Centre for Theoretical Physics, University of Groningen,Nijenborgh 4, 9747 AG Groningen (Netherlands); Hohm, Olaf [Simons Center for Geometry and Physics, Stony Brook University,Stony Brook, NY 11794-3636 (United States); Penas, Victor A. [Centre for Theoretical Physics, University of Groningen,Nijenborgh 4, 9747 AG Groningen (Netherlands); Riccioni, Fabio [INFN - Sezione di Roma, Dipartimento di Fisica, Università di Roma “La Sapienza”,Piazzale Aldo Moro 2, 00185 Roma (Italy)

    2016-06-06

    We present the dual formulation of double field theory at the linearized level. This is a classically equivalent theory describing the duals of the dilaton, the Kalb-Ramond field and the graviton in a T-duality or O(D,D) covariant way. In agreement with previous proposals, the resulting theory encodes fields in mixed Young-tableau representations, combining them into an antisymmetric 4-tensor under O(D,D). In contrast to previous proposals, the theory also requires an antisymmetric 2-tensor and a singlet, which are not all pure gauge. The need for these additional fields is analogous to a similar phenomenon for “exotic' dualizations, and we clarify this by comparing with the dualizations of the component fields. We close with some speculative remarks on the significance of these observations for the full non-linear theory yet to be constructed.

  11. Coupled Double Quantum Wells

    Directory of Open Access Journals (Sweden)

    Élder Mantovani Lopes

    2010-12-01

    Full Text Available The progress of the semiconductor growth techniques allows the opportunity to produce new semiconductors devices that may contribute to the development of the nanotechnology. The fabrication of semiconductor heterostructures with high quality allows the obtaining of new effects based on the quantum properties of those systems, which have stimulated great technological interest, especially on the optoelectronic and telecommunications fields. In this work some basic concepts related to one of those heterostructures are discussed: the Coupled Double Quantum Well (CDQW. The deduction of the expression for the determination of the energy levels in CDQWs is presented in details. The results obtained through this expression are compared with experimental results obtained through photoluminescence (PL measurements, complementing the work.

  12. Draping Double-Layer Woven Fabrics Onto Double-Curvature ...

    African Journals Online (AJOL)

    Draping woven fabrics to complex parts with double curvature leads to complex redistribution and reorientation of the yarns in composites reinforced with woven preforms. To reduce the risk of fabric tearing or wrinkling we propose to use double-layer woven fabrics. This paper presents a simulation model for draping

  13. Double-outlet right ventricle revisited.

    Science.gov (United States)

    Ebadi, Ameneh; Spicer, Diane E; Backer, Carl L; Fricker, F Jay; Anderson, Robert H

    2017-08-01

    Double-outlet right ventricle is a form of ventriculoarterial connection. The definition formulated by the International Society for Nomenclature of Paediatric and Congenital Heart Disease is based on hearts with both arterial trunks supported in their greater part by a morphologically right ventricle. Bilateral infundibula and ventricular septal defects are highly debated criteria. This study examines the anatomic controversies surrounding double-outlet right ventricle. We show that hearts with double-outlet right ventricle can have atrioventricular-to-arterial valvular continuity. We emphasize the difference between the interventricular communication and the zone of deficient ventricular septation. The hearts examined were from the University of Florida in Gainesville; Johns Hopkins All Children's Hospital, St Petersburg, Fla; and Lurie Children's Hospital, Chicago, Ill. Each specimen had at least 75% of both arterial roots supported by the morphologically right ventricle, with a total of 100 hearts examined. The morphologic method was used to assess anatomic features, including arterial-atrioventricular valvular continuity, subarterial infundibular musculature, and the location of the hole between the ventricles. Most hearts had fibrous continuity between one of the arterial valves and an atrioventricular valve, with bilateral infundibula in 23%, and intact ventricular septum in 5%. Bilateral infundibula are not a defining feature of double-outlet right ventricle, representing only 23% of the specimens in our sample. The interventricular communication can have a posteroinferior muscular rim or extend to become perimembranous (58%). Double-outlet right ventricle can exist with an intact ventricular septum. Copyright © 2017 The American Association for Thoracic Surgery. All rights reserved.

  14. Orbits of four double stars

    Directory of Open Access Journals (Sweden)

    Novaković B.

    2006-01-01

    Full Text Available We present orbits of four double stars. Orbits of stars WDS 23516+4205 = ADS 17050 and WDS 18239+5848 = ADS 11336 were calculated for the first time. Orbits of double stars WDS 02022+3643 = ADS 1613 and WDS 18443+3940 = ADS 11635 were revised. We have also determined their masses, dynamical parallaxes and ephemerides.

  15. Empirically Unbinding the Double Bind.

    Science.gov (United States)

    Olson, David H.

    The theoretical concept of the double bind and the possibilities for researching it are discussed. The author has observed that theory and research, which should be reciprocal and mutually beneficial, have been working, as concerns the double bind, at odds with one another. Two approaches to empirically investigating the concept are considered via…

  16. Hedging Double Barriers with Singles

    NARCIS (Netherlands)

    Sbuelz, A.

    2000-01-01

    Double barrier options provide risk managers with good-deal flexibility in tailoring portfolio returns.Their hedges offer full protection only if unwound along the barriers.This work provides non-dynamic hedges that project the risk of double barriers on to single barriers.Non-dynamic hedges

  17. Double layer relaxation in colloids

    NARCIS (Netherlands)

    Kijlstra, J.

    1992-01-01

    The purpose of the present study is to improve our insight into the relaxation of the electrical double layer around particles in hydrophobic sols. A detailed knowledge of the relaxation mechanisms is required to explain the behaviour of sols under conditions where the double layer is

  18. Double parton scattering theory overview

    NARCIS (Netherlands)

    Diehl, Markus; Gaunt, Jonathan R.

    2017-01-01

    The dynamics of double hard scattering in proton-proton collisions is quite involved compared with the familiar case of single hard scattering. In this contribution, we review our theoretical understanding of double hard scattering and of its interplay with other reaction mechanisms.

  19. Assessment

    Directory of Open Access Journals (Sweden)

    E.S. Mohamed

    2013-12-01

    Full Text Available Soil erosion, salinity and sodicity hazards are serious problems in the northern west coast of Egypt and lead to reducing the soil quality and increasing the degradation of soil resources. Sidi Barrani and Al-Sallum regions are selected as study areas which are located from a longitude of 25°10′00″ to 26°55′00″East and from a latitude of 31°00′0″ to 31°37′30″ North. Erosion hazard was estimated using the ‘Universal Soil Loss Equation’ (USLE, which is a simple empirical model that is widely used for assessing long-term annual soil loss .The salinity and sodicity hazards were estimated based on FAO method as standard reference. The resultant map of annual soil erosion shows a maximum soil loss of 60 t h−1 y−1 with a close relation to foot slopes and wide units on the steep side-slopes (with high LS value and the erodibility value reached to 0.1 t h−1 y−1. Meanwhile sand beaches and sabkha units are characterized by high environmental hazards of both water erosion, salinity and sodicity, while in the overflow basin units are identified as low environmental hazards. The spatial environmental hazards assessment is conducted by using integrated GIS and RS which can serve as effective inputs in deriving strategies for sustainable land use planning and management.

  20. Natural double inflation

    Science.gov (United States)

    Occhionero, F.; Litterio, M.; Capozziello, S.; Amendola, L.

    The astronomical interest of double inflation stems from the possibility it gives of inserting a feature in an otherwise featureless (or scale invariant) perturbation spectrum, precisely at the scale (100 Mpc, say) that goes through the horizon at the (sharp) separations between the two successive inflations. Double inflation occurs when two scalar fields (or inflatons) dominate sequentially the cosmic expansion or when vacuum polarization — Ricci scalar R squared added to the Lagrangian — is taken into account and only one inflaton ψ is present. (This perhaps is more natural as it exploits quantum effects to reduce to one the number of the ad hoc ingredients.) In that case we know from Starobinsky's pioneering work that the first inflation is driven by R — rightly called then scalaron — under the rules of Fourth Order Gravity, (FOG), while the second is driven by ψ under the rules of ordinary General Relativity, (GR). Unfortunately most of the appeal of the scalaron-inflaton scenario in relation to the feature in the perturbation spectrum, is lost because a delicate fine tuning of the value of the (second) inflaton at the beginning of the second inflation is required, in the absence of which the two inflations merge in one and no scale is singled out. In order to overcome this difficulty, we introduce in the Lagrangian density a new scalar coupling between ψ and R2, analogous to the well known non minimal coupling between ψ and R of canonical GR. We show that in this way the two inflationary episodes of FOG and GR may be neatly distinguished from each other, regardless of the initial value of ψ. This is due to the influence of the coupling on the shape of the conformal potential, in which one can easily carve a channel of evolution, consisting in fact of two orthogonal valleys. Then, for most of phase space the attractor is this doubly inflationary trajectory that lies at the bottom of the two valleys (Fig. 1). In fact, in this case the Universe first

  1. Comparative assessment of the effectiveness and tolerability of lornoxicam 8 mg BID and diclofenac 50 mg TID in adult indian patients with osteoarthritis of the hip or knee: A 4-week, double-blind, randomized, comparative, multicenter study.

    Science.gov (United States)

    Goregaonkar, Arvind; Mathiazhagan, K J; Shah, Ravindra R; Kapoor, Paramjeet Singh; Taneja, Praveen; Sharma, Akhilesh; Bolmall, Chandrashekhar; Baliga, Vidyagauri P

    2009-02-01

    Reports of cardiovascular adverse events (AEs) associated with the use of cyclooxygenase-2 inhibitors for the treatment of osteoarthritis (OA) have prompted the quest for a better-tolerated NSAID. The aim of this study was to compare the effectiveness and tolerability of lornoxicam 8 mg BID and diclofenac 50 mg TID in adult Indian patients with OA of the hip or knee. This 4-week, double-blind, randomized, comparative, multicenter study was undertaken to compare oral lornoxicam and diclofenac in patients with OA. Patients who met the selection criteria were enrolled consecutively from the outpatient clinics of each of the participating hospitals in India. Participants completed the Western Ontario and McMasters Individual Osteoarthritis Index (WOMAC-OA), WOMAC Composite Index (WOMAC-CI) (for pain, stiffness, and physical function), and a 10-cm visual analog scale (VAS) (0-10 where 0 = no pain and 10 = worst possible pain or severe or excruciating pain) at each study visit (weeks 0 [baseline], 2, and 4 [or at early termination]). Patients' and physicians' global assessments of arthritis control were measured at each study visit when laboratory and clinical AEs were also monitored. The primary end points were the WOMAC-OA, the WOMAC-CI, and VAS scores for pain among the patients who completed the study. Of the 273 patients (159 men, 114 women; mean [SD] age, 44.73 [10.72] years; range, 28-68 years) enrolled in the study, 13 (7 in the lornoxicam group and 6 in the diclofenac group) were lost to follow-up and their effectiveness and tolerability results were not included in the study analysis. Over the 4-week study period, both drugs provided significant (P < 0.05) sustained relief of OA symptoms compared with baseline. Compared with baseline, the mean pain score (WOMAC-CI) decreased 90.6% (13.88 [4.47] vs 1.30 [1.49]; P < 0.05) in the lornoxicam group and 88.9% (14.15 [4.56] vs 1.57 [1.49]; P < 0.05) in the diclofenac group after 4 weeks of treatment. After 4 weeks of

  2. Single-dose bioequivalence assessment of two formulations of polysaccharide iron complex capsules in healthy adult male Chinese volunteers: A sequence-randomized, double-blind, two-way crossover study.

    Science.gov (United States)

    Zhang, Yuan-Yuan; Liu, Jun-Hong; Su, Feng; Lui, Ying-Tao; Li, Jun-Feng

    2009-04-01

    Iron deficiency anemia (IDA) is a common nutritional disease worldwide. Iron supplementation is an efficient method for treating patients with IDA. Polysaccharide iron complex is an oral iron supplement that is associated with generally good tolerability and good bioavailability. The aim of this study was to evaluate the bioequivalence of 2 branded formulations of polysaccharide iron complex in healthy adult male Chinese volunteers by determining the pharmacokinetic parameters after single-dose oral admi ni strati on. This sequence-randomized, double-blind, 2-way crossover study was carried out in the Affiliated Hospital, Institute of Medical Sciences of Qingdao University, Qingdao, China. Healthy adult male Chinese volunteers were enrolled and evenly randomized to receive 1 of 2 formulations on day 1. Subjects received an oral dose of 150 mg (1 capsule) of polysaccharide iron complex with 150 mL of warm water in the morning. Capsules were of similar size, shape, and color to ensure blinding. Four hours after administration, the subjects were given standardized meals. After a 1-week washout period, the subjects were crossed over to receive the other formulation in a similar manner. The serum iron concentration 12 hours after study drug administration was determined using atomic-absorption spectrometry. The pharmacokinetic parameters Cmax, Tmax, AUC0-t, and AUC0-∞ were obtained and analyzed using the Schuir mann 2 one-sided t test. The 2 formulations were considered bioequi valent if the test/reference ratios of Cmax, AUC0-t, and their 90% CIs were within the range of 70% to 143% for Cmax and within 80% to 125% for AUC0-t. Tolerability was monitored by inquiring whether the subjects had experienced adverse events (AEs), with a focus on gastrointestinal AEs, during the clinic visits during the 24-hour period after drag administration and subsequently via telephone throughout the study. Thirty adult male Chinese volunteers were assessed for inclusion. Twenty healthy

  3. A Handbook of Double Stars

    Science.gov (United States)

    Crossley, Edward; Gledhill, Joseph; Wilson, James M.

    2011-11-01

    Preface; Part I. Historical, and Descriptive of Instruments and Methods: 1. Historical introduction; 2. The Equatorial: its construction and adjustments; 3. Some account of the Equatorials which have been used by double-star observers; 4. The micrometer; 5. Methods of observing double stars; Part II. On the Calculation of the Orbit of a Binary Star: 1. Introduction; 2. Example of an orbit worked by a graphical method; 3. Dr. Doberck's example of an orbit worked by analytical methods; 4. On relative rectilinear motion; 5. On the effect of proper motion and parallax on the observed position angles and distance of an optically double star; 6. On the errors of observation and the combination of observations; Part III. The Catalogue and Measures: Introductory remarks; A catalogue of binary and other double starts deserving of attention; Lists of measures, with historical notes, etc.; Supplementary list of measures; Appendix; Additional notes to measures; Binary stars classified; Note on systematic errors in the measures of angle and distance of double stars; Part IV. Bibliography: A. Some of the most important works and papers on double stars; B. Some papers on the micrometer; C. Some papers on the colours of double stars; Additional notes; Corrections 1880.

  4. Creative Double Bind in Oral Interpretation.

    Science.gov (United States)

    Peterson, Eric E.; Langellier, Kristin M.

    1982-01-01

    Explains how oral interpretation is uniquely communicative and how the double bind theory of communication can include creativity. Discusses (1) double bind and oral interpretation, (2) creating aesthetic text, and (3) the performance of double bind. (PD)

  5. Hitchcock’s queer doubles

    Directory of Open Access Journals (Sweden)

    Alessandra Brandão

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2013n65p17   The “double” is a well-known Hitchcockian motif. Widelyreviewed under a psychoanalytical perspective, the issue ofthe double still presents other important challenges and thisarticle aims at discussing the queer doubles in Hitchcock’s films as “falsifiers” who are opposed to non-queer doubles thatemphasise narrative coherence and legibility. In films such asRebeca, Rope, Vertigo, The Birds, Psycho, and Frenzy, a doublecondenses impulses that are well described by Lee Edelman: “theviolent undoing of meaning, the loss of identity and coherence,the unnatural access to jouissance” (132. These doubles releasethe powers of the false as they complicate the return to an “order”.Therefore, we could argue that such characters are closer tobeing Deleuzian simulacra than psychoanalytical doppelgängers.

  6. Species doubling and effective Lagrangians

    Energy Technology Data Exchange (ETDEWEB)

    Creutz, M.; Tytgat, M.

    1996-09-01

    Coupling gauge fields to the chiral currents from an effective Lagrangian for pseudoscalar mesons naturally gives rise to a species doubling phenomenon similar to that seen with fermionic fields in lattice gauge theory. 17 refs.

  7. The Double Love Commandment

    Directory of Open Access Journals (Sweden)

    Francois P. Viljoen

    2015-03-01

    Full Text Available The Gospel of Matthew was written during a period of dispute between the Matthean community and their fellow Jews, with the Pharisees playing a leading role. The Matthean community was heir to the same scriptures as its opponents. They continued to have a firm commitment to the Torah, but they developed a distinctive understanding of it based on Jesus’ teaching. The formation of this community is investigated in this article, considering the Mediterranean perspectives of group-oriented societies prevalent in the first century. Such a group provided a sense of self and an interactive support system, where love functioned to bind the group together. The subordinates showed their undivided loyalty towards their superiors because of the favours they received from them, whilst they supported and cared for other members within the group as they care for themselves. Reading the double love commandment of Matthew 22:34−40 from this perspective reveals significant aspects of the community’s identity with regard to their commitment to God and their view of their neighbours. Die Dubbele Liefdesgebod. Die Matteusevangelie is gedurende ’n periode van konfliktussen die Matteusgemeenskap en mede-Jode geskryf met die Fariseërs in ’n leidende rol. Die Matteusgemeenskap het van dieselfde geskrifte as hulle opponente gebruik gemaak. Hulle was steeds aan die Torah lojaal, maar het ’n unieke interpretasie daarvan gehuldig, gebaseer op die onderrig van Jesus. In hierdie artikel word die vorming van die Matteusgemeenskap ondersoek met inagneming van die Mediterreense beskouing van die groepgeoriënteerde gemeenskappe wat tipies van die eerste eeu was. So ’n groep het aan individue ’n bewustheid van eie waarde verskaf te midde van ’n interaktiewe ondersteuningsisteem waarin liefde as samebindende faktor gefunksioneer het. Ondergeskiktes het onverdeelde lojaliteit teenoor hulle meerderes betoon vanweë die gunste wat hulle van die meerderes geniet het

  8. The Double Love Commandment

    Directory of Open Access Journals (Sweden)

    Francois P. Viljoen

    2015-03-01

    Full Text Available The Gospel of Matthew was written during a period of dispute between the Matthean community and their fellow Jews, with the Pharisees playing a leading role. The Matthean community was heir to the same scriptures as its opponents. They continued to have a firm commitment to the Torah, but they developed a distinctive understanding of it based on Jesus’ teaching. The formation of this community is investigated in this article, considering the Mediterranean perspectives of group-oriented societies prevalent in the first century. Such a group provided a sense of self and an interactive support system, where love functioned to bind the group together. The subordinates showed their undivided loyalty towards their superiors because of the favours they received from them, whilst they supported and cared for other members within the group as they care for themselves. Reading the double love commandment of Matthew 22:34−40 from this perspective reveals significant aspects of the community’s identity with regard to their commitment to God and their view of their neighbours.Die Dubbele Liefdesgebod. Die Matteusevangelie is gedurende ’n periode van konfliktussen die Matteusgemeenskap en mede-Jode geskryf met die Fariseërs in ’n leidende rol. Die Matteusgemeenskap het van dieselfde geskrifte as hulle opponente gebruik gemaak. Hulle was steeds aan die Torah lojaal, maar het ’n unieke interpretasie daarvan gehuldig, gebaseer op die onderrig van Jesus. In hierdie artikel word die vorming van die Matteusgemeenskap ondersoek met inagneming van die Mediterreense beskouing van die groepgeoriënteerde gemeenskappe wat tipies van die eerste eeu was. So ’n groep het aan individue ’n bewustheid van eie waarde verskaf te midde van ’n interaktiewe ondersteuningsisteem waarin liefde as samebindende faktor gefunksioneer het. Ondergeskiktes het onverdeelde lojaliteit teenoor hulle meerderes betoon vanweë die gunste wat hulle van die meerderes geniet het

  9. Keepers of the Double Stars

    OpenAIRE

    Tenn, Joseph S.

    2013-01-01

    Astronomers have long tracked double stars in efforts to find those that are gravitationally-bound binaries and then to determine their orbits. Early catalogues by the Herschels, Struves, and others began with their own discoveries. In 1906 court reporter and amateur astronomer Sherburne Wesley Burnham published a massive double star catalogue containing data from many observers on more than 13,000 systems. Lick Observatory astronomer Robert Grant Aitken produced a much larger catalogue in 19...

  10. Double parton scattering in CMS

    CERN Document Server

    Sunar Cerci, Deniz

    2017-01-01

    Recent results on the double parton scattering measurements performed using the proton-proton collision data collected with the CMS detector are presented. The observables, which are sensitive to double parton scattering, are investigated after being corrected for detector effects and selection efficiencies. Multivariate analysis techniques are used for increasing the sensitivity. The effective cross section, $\\sigma_{eff}$ is also extracted using different processes at various center-of-mass energies.

  11. Supermagic Generalized Double Graphs 1

    Directory of Open Access Journals (Sweden)

    Ivančo Jaroslav

    2016-02-01

    Full Text Available A graph G is called supermagic if it admits a labelling of the edges by pairwise di erent consecutive integers such that the sum of the labels of the edges incident with a vertex is independent of the particular vertex. In this paper we will introduce some constructions of supermagic labellings of some graphs generalizing double graphs. Inter alia we show that the double graphs of regular Hamiltonian graphs and some circulant graphs are supermagic.

  12. A randomized, double-blind, comparative study to assess the safety and efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of secondarily infected traumatic lesions and impetigo due to methicillin-resistant Staphylococcus aureus.

    Science.gov (United States)

    Tanus, Tonny; Scangarella-Oman, Nicole E; Dalessandro, Marybeth; Li, Gang; Breton, John J; Tomayko, John F

    2014-12-01

    To evaluate the clinical and bacteriological efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of patients with secondarily infected traumatic lesions (SITLs; excluding abscesses) or impetigo due to methicillin-resistant Staphylococcus aureus (MRSA). A randomized, double-blind, double-dummy, multicenter, comparative study (NCT00852540). Patients recruited from 36 study centers in the United States. Patients 2 months or older with SITL (including secondarily infected lacerations or sutured wounds) or impetigo (bullous and nonbullous) suitable for treatment with a topical antibiotic, with a total Skin Infection Rating Scale score of 8 or greater, including a pus/exudate score of 3 or greater. Patients received retapamulin ointment 1% (plus oral placebo), twice daily for 5 days or oral linezolid (plus placebo ointment) 2 or 3 times daily for 10 days. Primary end point: clinical response (success/failure) at follow-up in patients with MRSA at baseline (per-protocol population). Secondary efficacy end points: clinical and microbiologic response and outcome at follow-up and end of therapy; therapeutic response at follow-up. The majority of patients had SITL (70.4% [188/267] and 66.4% [91/137] in the retapamulin and linezolid groups, respectively; intent-to-treat clinical population). Clinical success rate at follow-up was significantly lower in the retapamulin versus the linezolid group (63.9% [39/61] vs 90.6% [29/32], respectively; difference in success rate -26.7%; 95% CI, -45.7 to -7.7). Clinical success rate at follow-up in the per-protocol MRSA population was significantly lower in the retapamulin versus the linezolid group. It could not be determined whether this was related to study design, bacterial virulence, or retapamulin activity.

  13. Alternate Double Single Track Lines

    Energy Technology Data Exchange (ETDEWEB)

    Moraga Contreras, P.; Grande Andrade, Z.; Castillo Ron, E.

    2016-07-01

    The paper discusses the advantages and shortcomings of alternate double single track (ADST) lines with respect to double track lines for high speed lines. ADST lines consists of sequences of double and single track segments optimally selected in order to reduce the construction and maintenance costs of railway lines and to optimize the timetables used to satisfy a given demand. The single tracks are selected to coincide with expensive segments (tunnels and viaducts) and the double tracks are chosen to coincide with flat areas and only where they are necessary. At the same time, departure times are adjusted for trains to cross at the cheap double track segments. This alternative can be used for new lines and also for existing conventional lines where some new tracks are to be constructed to reduce travel time (increase speed). The ADST proposal is illustrated with some examples of both types (new lines and where conventional lines exist), including the Palencia-Santander, the Santiago-Valparaíso-Viña del Mar and the Dublin-Belfast lines, where very important reductions (90 %) are obtained, especially where a railway infrastructure already exist. (Author)

  14. Azeglio Bemporad and the "BEM" Double Stars

    Science.gov (United States)

    Smith, Steven; Prunotto, Marco

    2017-07-01

    This paper aims to describe the scientific context and the life of early 20th century Italian astronomer Azeglio Bemporad (1875-1945), his work on double stars, and how the “BEM” doubles were incorporated into the Washington Double Star catalog. Included are new measures, a complete photo gallery of all 61 of his double star systems, and copies of his double star publications.

  15. The Doubling Undone? Double Effect in Recent Medical Ethics ...

    African Journals Online (AJOL)

    This article treats recent bioethical discussions of double effect reasoning (DER), offering a summary account of DER and construing it as rooted in a sensible view of what is central to someone's identity as a moral agent. It then treats objections raised in recent years by Judith Thomson, Alison McIntyre, and Frances Kamm ...

  16. Analysis of stroke in ATHENA: a placebo-controlled, double-blind, parallel-arm trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation/atrial flutter.

    Science.gov (United States)

    Connolly, Stuart J; Crijns, Harry J G M; Torp-Pedersen, Christian; van Eickels, Martin; Gaudin, Christophe; Page, Richard L; Hohnloser, Stefan H

    2009-09-29

    Many patients with atrial fibrillation are at high risk for stroke and require antithrombotic therapy. Antiarrhythmic drugs have not previously been shown to reduce the risk of stroke in atrial fibrillation. The effect of dronedarone, a new multichannel-blocking antiarrhythmic drug, on stroke has been evaluated in a randomized, double-blind clinical trial, ATHENA (A placebo-controlled, double-blind, parallel-arm Trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atrial flutter). Patients with persistent or paroxysmal atrial fibrillation and at least 1 risk factor for cardiovascular hospitalization were randomized to receive dronedarone (400 mg BID) or double-blind matching placebo and followed up for a minimum of 1 year to a common termination at 30 months. All strokes that occurred during the study were included in the present post hoc analysis. There were 4628 patients randomized to placebo or dronedarone. The baseline risk factors for stroke were well balanced between the 2 groups, and the baseline mean CHADS(2) score was 2. The baseline use of either oral anticoagulant therapy or antiplatelet agent alone was 60%. Dronedarone reduced the risk of stroke from 1.8% per year to 1.2% per year (hazard ratio 0.66, 95% confidence interval 0.46 to 0.96, P=0.027). The effect of dronedarone was similar whether or not patients were receiving oral anticoagulant therapy, and there was a significantly greater effect of dronedarone in patients with higher CHADS(2) scores. In this post hoc analysis, a reduction in stroke was observed in patients with atrial fibrillation who were receiving usual care, which included antithrombotic therapy and heart rate control, who were randomized to dronedarone. Further studies to investigate the effect of dronedarone and other antiarrhythmic agents on stroke are indicated.

  17. Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I.

    Science.gov (United States)

    Grunze, Heinz; Kotlik, Eduardo; Costa, Raquel; Nunes, Teresa; Falcão, Amílcar; Almeida, Luis; Soares-da-Silva, Patrício

    2015-03-15

    Eslicarbazepine acetate (ESL) is an anticonvulsant approved as an adjunctive therapy in adults with partial-onset seizures. To evaluate the efficacy, safety and tolerability of ESL in the treatment of acute mania and prevention of recurrence in bipolar disorder I. Two 3-week multicentre, double-blind, randomised, placebo-controlled studies in acute mania (study BIA-2093-203: dose titrated by response, ESL 600-1800mg or 800-2400mg, once-daily; study BIA-2093-204: fixed doses of 600, 1200 and 1800mg, once-daily) were followed by a recurrence prevention study consisting of a 2-week open-label period (900mg, once-daily) continued by a double-blind, parallel-group, fixed dose (300, 900 and 1800mg, once-daily) period for a minimum of 6 months. The primary endpoint was changed from baseline until the end of the 3-week treatment period in Young Mania Rating Scale (YMRS) in studies BIA-2093-203 and BIA-2093-204, and the proportion of patients showing no worsening according to the Clinical Global Impressions - Bipolar Version (CGI-BP) over Part II in study BIA-2093-205. In study BIA-2093-203 (n=160, ITT), neither dose group was statistically different from placebo in the primary endpoint, though the ESL 800-2400mg showed a greater reduction in YMRS score (p=0.0523). CGI-BP score changes for mania and overall bipolar illness indicate a significant improvement in patient symptomatology for the ESL 800-2400mg group (from preceding and worst phase) and for ESL 600-1800mg group (from worst phase only) when compared to placebo. Study BIA-2093-204 (n=38) results were inconclusive due to premature termination caused by recruitment difficulties. In study BIA-2093-205 (n=85, ITT), at least 50% of patients showed no worsening in all treatment groups (p=0.250). ESL adverse events were mostly of mild and moderate intensities and consistent with previously reported observations for ESL. ESL treatment was not significantly different from placebo in manic patients in the primary outcome

  18. Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation.

    Science.gov (United States)

    Soiffer, Robert J; Kim, Haesook T; McGuirk, Joseph; Horwitz, Mitchell E; Johnston, Laura; Patnaik, Mrinal M; Rybka, Witold; Artz, Andrew; Porter, David L; Shea, Thomas C; Boyer, Michael W; Maziarz, Richard T; Shaughnessy, Paul J; Gergis, Usama; Safah, Hana; Reshef, Ran; DiPersio, John F; Stiff, Patrick J; Vusirikala, Madhuri; Szer, Jeff; Holter, Jennifer; Levine, James D; Martin, Paul J; Pidala, Joseph A; Lewis, Ian D; Ho, Vincent T; Alyea, Edwin P; Ritz, Jerome; Glavin, Frank; Westervelt, Peter; Jagasia, Madan H; Chen, Yi-Bin

    2017-10-17

    Purpose Several open-label randomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; formerly antithymocyte globulin-Fresenius) reduces chronic graft-versus-host disease (cGVHD) without compromising survival. We report a prospective, double-blind phase III trial to investigate the effect of ATLG (Neovii Biotech, Lexington, MA) on cGVHD-free survival. Patients and Methods Two hundred fifty-four patients 18 to 65 years of age with acute leukemia or myelodysplastic syndrome who underwent myeloablative HLA-matched unrelated hematopoietic cell transplantation (HCT) were randomly assigned one to one to placebo (n =128 placebo) or ATLG (n = 126) treatment at 27 sites. Patients received either ATLG or placebo 20 mg/kg per day on days -3, -2, -1 in addition to tacrolimus and methotrexate as GVHD prophylaxis. The primary study end point was moderate-severe cGVHD-free survival. Results Despite a reduction in grade 2 to 4 acute GVHD (23% v 40%; P = .004) and moderate-severe cGVHD (12% v 33%; P < .001) in ATLG recipients, no difference in moderate-severe cGVHD-free survival between ATLG and placebo was found (2-year estimate: 48% v 44%, respectively; P = .47). Both progression-free survival (PFS) and overall survival (OS) were lower with ATLG (2-year estimate: 47% v 65% [ P = .04] and 59% v 74% [ P = .034], respectively). Multivariable analysis confirmed that ATLG was associated with inferior PFS (hazard ratio, 1.55; 95% CI, 1.05 to 2.28; P = .026) and OS (hazard ratio, 1.74; 95% CI, 1.12 to 2.71; P = .01). Conclusion In this prospective, randomized, double-blind trial of ATLG in unrelated myeloablative HCT, the incorporation of ATLG did not improve moderate-severe cGVHD-free survival. Moderate-severe cGVHD was significantly lower with ATLG, but PFS and OS also were lower. Additional analyses are needed to understand the appropriate role for ATLG in HCT.

  19. A Mixed Model for Double Checking Fallible Auditors

    NARCIS (Netherlands)

    Raats, V.M.; Moors, J.J.A.; van der Genugten, B.B.

    2004-01-01

    The paper discusses the problem of a fallible auditor who assesses the values of sampled records, but may make mistakes.To detect these mistakes, a subsample of the checked elements is checked again, now by an infallible expert. We propose a model for this kind of double check, which takes into

  20. A double-blinded, randomized, vehicle-controlled, multicenter, parallel-group study to assess the safety and efficacy of tretinoin gel microsphere 0.04% in the treatment of acne vulgaris in adults.

    Science.gov (United States)

    Berger, Richard; Barba, Alicia; Fleischer, Alan; Leyden, James J; Lucky, Anne; Pariser, David; Rafal, Elyse; Thiboutot, Diane; Wilson, David; Grossman, Rachel; Nighland, Marge

    2007-08-01

    This double-blinded, randomized, vehicle-controlled, multicenter, parallel-group, 12-week, phase 4 study was conducted in adults with mild to moderate acne vulgaris. Of 178 subjects randomized to be treated, 88 subjects (49%) were treated with tretinoin gel microsphere 0.04% and 90 subjects (51%) were treated with vehicle. Inflammatory lesion counts were statistically significantly reduced at 2 weeks in tretinoin-treated subjects (P = .0110), and reductions in total lesion counts also were noted. The reduction in total lesion counts reached statistical significance at week 4 (P = .0305); at week 12, mean total, inflammatory, and noninflammatory lesion counts were statistically significantly lower in the tretinoin treatment group versus vehicle group (P tretinoin compared with vehicle (P tretinoin treatment group compared with 20.9%, 19.2%, and 20.4%, respectively, for the vehicle group (all P tretinoin-treated subject. At week 12, there were no statistically significant differences between treatment groups for any measured tolerability parameter.

  1. Assessment of an updated double-vasopressor automated system using Nexfin for the maintenance of haemodynamic stability to improve peri-operative outcome during spinal anaesthesia for caesarean section.

    Science.gov (United States)

    Sng, B L; Wang, H; Assam, P N; Sia, A T

    2015-06-01

    Hypotension occurs commonly during spinal anaesthesia for caesarean section, associated with maternal and fetal adverse effects. We developed a double-vasopressor automated system with a two-step algorithm and continuous non-invasive haemodynamic monitoring using the Nexfin device. The system delivered 25 μg phenylephrine every 30 s when systolic blood pressure was between 90% and 100% of baseline, or 2 mg ephedrine at this blood pressure range and heart rate anaesthesia. Twenty-seven (47.4%) had at least one reading of hypotension defined as systolic blood pressure < 80% baseline. Systolic blood pressure was within 20% of the baseline in a mean (SD) of 79.8 (20.9)% of measurements. Fifty-three (93.0%) women required phenylephrine before delivery while 10 (17.5%) required ephedrine. Six women (10.5%) experienced nausea and three (5.3%) vomited. The system was able to achieve a low incidence of maternal hypotension with good maternal and fetal outcomes. © 2015 The Association of Anaesthetists of Great Britain and Ireland.

  2. Doubled-ended ceramic thyratron

    CERN Multimedia

    1974-01-01

    The double-ended ceramic thyratron CX 1171 B, with its coaxial voltage divider for the SPS. Such a switch, paralleled by three ignitrons in series forms the "thyragnitron" arrangement, and can switch 10 kA, 25 ms pulses, with very fast rise times.

  3. Magnetoresistance stories of double perovskites

    Indian Academy of Sciences (India)

    out. Keywords. Tunnelling magnetoresistance; tunnel boundary; disorder; double perovskite. PACS Nos 75.47.−m; 73.40.Gk; 72.80.Ga. 1. Introduction. Magnetoresistance (MR) is the property of a material to change the value of its electri- cal resistance when an external magnetic field is applied. This phenomenon was first.

  4. Double Coffee opens in China

    Index Scriptorium Estoniae

    2009-01-01

    Läti suursaadik Ingrida Levrence avas esimese Double Coffee kohviku Hiina pealinnas Pekingi südames. Rahvusvaheline kohvikukett kavatseb laieneda mõne kohviku võrra igal aastal. Seni tegutsetakse Lätis, Eestis, Leedus, Ukrainas ja Valgevenes

  5. Micrometer measurements of double stars

    Directory of Open Access Journals (Sweden)

    Zulević D.J.

    2000-01-01

    Full Text Available A set of 71 measurements of double and multiple stars, carried out with the Large Zeiss Refractor 65/1055 cm of the Belgrade Observatory, is communicated. The bulk of these measurements, 41 in all, unpublished yet, is due to late D. Zulević.

  6. A Double-Minded Fractal

    Science.gov (United States)

    Simoson, Andrew J.

    2009-01-01

    This article presents a fun activity of generating a double-minded fractal image for a linear algebra class once the idea of rotation and scaling matrices are introduced. In particular the fractal flip-flops between two words, depending on the level at which the image is viewed. (Contains 5 figures.)

  7. Double obstruction of ureter: A diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Pankaj Halder

    2014-01-01

    Full Text Available Introduction: Isolated obstruction of the ureteropelvic junction and the vesico-ureteric junction are the two most common causes of hydronephrosis in a pediatric population. [1] They do not pose diagnostic difficulties when are present alone but when together can be difficult to diagnose. Here, we discuss the problems we faced when we encountered these two anomalies in the same ureter and the way in which we managed them. Aim: To assess the difficulties in diagnosis of pediatric patients who present with both ureteropelvic junction obstruction (UPJO and vesico-ureteric junction obstruction (VUJO in the ipsilateral ureter and their management protocol. Materials and Methods: This is a retrospective study. The study period is from 1 January 2004 to 31 December 2011. Out of 254 children who were diagnosed to have hydronephrosis due to UPJO in our institute, 5 patients (in the age range of 5 to 10 years had both UPJO and VUJO in the ipsilateral ureter. The problems we faced in diagnosing the two conditions are mentioned with a literature review. Results: Operative intervention was used in four out of five patients; none of the patients had an accurate diagnosis before surgery. All patients were suspected of having double obstruction during pyeloplasty when appropriate size double J stent could not be negotiated through the vesicoureteric junction into the bladder. Postoperative nephrostogram confirmed the diagnosis in all patients. Conclusion: Children with double obstruction of the ipsilateral ureter present as a diagnostic dilemma. Because of the rarity of this condition it can escape the eye of even an astute clinician. Early diagnosis can be made if this condition is kept in mind while treating any hydronephrosis due to UPJO or UVJO.

  8. Daugherty Memorial Assessment Center (DMAC)

    Data.gov (United States)

    Federal Laboratory Consortium — Daugherty Memorial Assessment Center (DMAC) is a 39,000-square-foot facility that doubles the warfare center's high-secured performance assessment capabilities. DMAC...

  9. Liraglutide in an Adolescent Population with Obesity: A Randomized, Double-Blind, Placebo-Controlled 5-Week Trial to Assess Safety, Tolerability, and Pharmacokinetics of Liraglutide in Adolescents Aged 12-17 Years.

    Science.gov (United States)

    Danne, Thomas; Biester, Torben; Kapitzke, Kerstin; Jacobsen, Sanja H; Jacobsen, Lisbeth V; Petri, Kristin C Carlsson; Hale, Paula M; Kordonouri, Olga

    2017-02-01

    To investigate the safety, tolerability, and pharmacokinetics of liraglutide in adolescents with obesity. This was a randomized, double-blind, placebo-controlled trial. Twenty-one subjects, aged 12-17 years and Tanner stage 2-5, with obesity (body mass index [BMI] corresponding to both a BMI ≥95th percentile for age and sex and to a BMI of ≥30 kg/m2 for adults; additionally, BMI was ≤45 kg/m2) were randomized (2:1) to receive 5 weeks of treatment with liraglutide (0.6 mg with weekly dose increase to a maximum of 3.0 mg for the last week) (n = 14) or placebo (n = 7). The primary endpoint was number of treatment-emergent adverse events (TEAEs). Secondary endpoints included safety measures, and pharmacokinetic and pharmacodynamic endpoints. All participants receiving liraglutide, and 4 receiving placebo (57.1%), had at least 1 TEAE. The most common TEAEs were gastrointestinal disorders. No severe TEAEs, TEAE-related withdrawals, or deaths occurred. Twelve hypoglycemic episodes occurred in 8 participants receiving liraglutide and 2 in 1 participant receiving placebo. No severe hypoglycemic episodes were reported. Liraglutide exposure in terms of trough concentration increased with dose, although dose proportionality was confounded by unexpectedly low trough concentration values at the 2.4 mg dose. Exposure in terms of model-derived area under the plasma concentration time curve from 0 to 24 hours after dose in steady state was similar to that in adults with obesity. Liraglutide had a similar safety and tolerability profile compared with adults when administered to adolescents with obesity, with no unexpected safety/tolerability issues. Results suggest that the dosing regimen approved for weight management in adults may be appropriate for use in adolescents. ClinicalTrials.gov: NCT01789086. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Pathways to doubled haploidy: chromosome doubling during androgenesis.

    Science.gov (United States)

    Seguí-Simarro, J M; Nuez, F

    2008-01-01

    Production of doubled haploid (DH) plants through androgenesis induction is a promising and convenient alternative to conventional selfing techniques for the generation of pure lines for breeding programs. This process comprises two main steps: induction of androgenesis and duplication of the haploid genome. Such duplication is sometimes indirectly induced by the treatments used to promote androgenic development. But usually, an additional step of direct chromosome doubling must be included in the protocol. Duplication of the haploid genome of androgenic individuals has been thought to occur through three mechanisms: endoreduplication, nuclear fusion and c-mitosis. In this review we will revise and analyze the evidences supporting each of the proposed mechanisms and their relevance during androgenesis induction, embryo/callus development and plant regeneration. Special attention will be devoted to nuclear fusion, whose evidences are accumulating in the last years. 2008 S. Karger AG, Basel

  11. Lightweight Double Neutron Star Found

    Science.gov (United States)

    Kohler, Susanna

    2018-02-01

    More than forty years after the first discovery of a double neutron star, we still havent found many others but a new survey is working to change that.The Hunt for PairsThe observed shift in the Hulse-Taylor binarys orbital period over time as it loses energy to gravitational-wave emission. [Weisberg Taylor, 2004]In 1974, Russell Hulse and Joseph Taylor discovered the first double neutron star: two compact objects locked in a close orbit about each other. Hulse and Taylors measurements of this binarys decaying orbit over subsequent years led to a Nobel prize and the first clear evidence of gravitational waves carrying energy and angular momentum away from massive binaries.Forty years later, we have since confirmed the existence of gravitational waves directly with the Laser Interferometer Gravitational-Wave Observatory (LIGO). Nonetheless, finding and studying pre-merger neutron-star binaries remains a top priority. Observing such systems before they merge reveals crucial information about late-stage stellar evolution, binary interactions, and the types of gravitational-wave signals we expect to find with current and future observatories.Since the Hulse-Taylor binary, weve found a total of 16 additional double neutron-star systems which represents only a tiny fraction of the more than 2,600 pulsars currently known. Recently, however, a large number of pulsar surveys are turning their eyes toward the sky, with a focus on finding more double neutron stars and at least one of them has had success.The pulse profile for PSR J1411+2551 at 327 MHz. [Martinez et al. 2017]A Low-Mass DoubleConducted with the 1,000-foot Arecibo radio telescope in Puerto Rico, the Arecibo 327 MHz Drift Pulsar Survey has enabled the recent discovery of dozens of pulsars and transients. Among them, as reported by Jose Martinez (Max Planck Institute for Radio Astronomy) and coauthors in a recent publication, is PSR J1411+2551: a new double neutron star with one of the lowest masses ever measured

  12. A double-sided linear primary permanent magnet vernier machine.

    Science.gov (United States)

    Du, Yi; Zou, Chunhua; Liu, Xianxing

    2015-01-01

    The purpose of this paper is to present a new double-sided linear primary permanent magnet (PM) vernier (DSLPPMV) machine, which can offer high thrust force, low detent force, and improved power factor. Both PMs and windings of the proposed machine are on the short translator, while the long stator is designed as a double-sided simple iron core with salient teeth so that it is very robust to transmit high thrust force. The key of this new machine is the introduction of double stator and the elimination of translator yoke, so that the inductance and the volume of the machine can be reduced. Hence, the proposed machine offers improved power factor and thrust force density. The electromagnetic performances of the proposed machine are analyzed including flux, no-load EMF, thrust force density, and inductance. Based on using the finite element analysis, the characteristics and performances of the proposed machine are assessed.

  13. A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose.

    Science.gov (United States)

    Struys, Michel M R F; Valk, Beatrijs I; Eleveld, Douglas J; Absalom, Anthony R; Meyer, Peter; Meier, Sascha; den Daas, Izaak; Chou, Thomas; van Amsterdam, Kai; Campagna, Jason A; Sweeney, Steven P

    2017-07-01

    Cyclopropyl-methoxycarbonylmetomidate (ABP-700) is a new "soft" etomidate analog. The primary objectives of this first-in-human study were to describe the safety and efficacy of ABP-700 and to determine its maximum tolerated dose. Secondary objectives were to characterize the pharmacokinetics of ABP-700 and its primary metabolite (cyclopropyl-methoxycarbonyl acid), to assess the clinical effects of ABP-700, and to investigate the dose-response and pharmacokinetic/pharmacodynamic relationships. Sixty subjects were divided into 10 cohorts and received an increasing, single bolus of either ABP-700 or placebo. Safety was assessed by clinical laboratory evaluations, infusion-site reactions, continuous monitoring of vital signs, physical examination, adverse event monitoring, and adrenocorticotropic hormone stimulation testing. Clinical effects were assessed with modified observer's assessment of alertness/sedation and Bispectral Index monitoring. Pharmacokinetic parameters were calculated. Stopping criteria were met at 1.00 mg/kg dose. No serious adverse events were reported. Adverse events were dose-dependent and comprised involuntary muscle movement, tachycardia, and ventilatory effects. Adrenocorticotropic hormone stimulation evoked a physiologic cortisol response in all subjects, no different from placebo. Pharmacokinetics were dose-proportional. A three-compartment pharmacokinetic model described the data well. A rapid onset of anesthesia/sedation after bolus administration and also a rapid recovery were observed. A quantitative concentration-effect relationship was described for the modified observer's assessment of alertness/sedation and Bispectral Index. This first-in-human study of ABP-700 shows that ABP-700 was safe and well tolerated after single-bolus injections up to 1.00 mg/kg. Bolus doses of 0.25 and 0.35 mg/kg were found to provide the most beneficial clinical effect versus side-effect profile.

  14. Double blind randomized phase II study with radiation + 5-fluorouracil ± celecoxib for resectable rectal cancer

    National Research Council Canada - National Science Library

    Debucquoy, Annelies; Roels, Sarah; Goethals, Laurence; Libbrecht, Louis; Cutsem, Eric Van; Geboes, Karel; Penninckx, Freddy; D’Hoore, André; McBride, William H; Haustermans, Karin

    2009-01-01

    To assess the feasibility and efficacy of the COX-2 inhibitor celecoxib in conjunction with preoperative chemoradiation for patients with locally advanced rectal cancer in a double blind randomized phase II study...

  15. TOPICAL REVIEW: Double beta decay

    Science.gov (United States)

    Faessler, Amand; Simkovic, Fedor

    1998-12-01

    We review the recent developments in the field of nuclear double beta decay, which is presently an important topic in both nuclear and particle physics. The mechanism of lepton number violation within the neutrinoless double beta decay (0954-3899/24/12/001/img5-decay) is discussed in the context of the problem of neutrino mixing and the R-parity violating supersymmetric extensions of the standard model. The problem of reliable determination of the nuclear matrix elements governing both two-neutrino and neutrinoless modes of the double beta decay is addressed. The validity of different approximation schemes in the considered nuclear structure studies is analysed and the role of the Pauli exclusion principle for a correct treatment of nuclear matrix elements is emphasized. The constraints on different lepton-number violating parameters such as effective electron neutrino mass, effective right-handed weak interaction parameters, effective Majoron coupling constant and R-parity violating SUSY parameters are derived from the best presently available experimental limits on the half-life of 0954-3899/24/12/001/img5-decay.

  16. Double-Critical Graphs and Complete Minors

    DEFF Research Database (Denmark)

    Kawarabayashi, Ken-ichi; Pedersen, Anders Sune; Toft, Bjarne

    2010-01-01

      A connected $k$-chromatic graph $G$ is double-critical if for all edges $uv$ of $G$ the graph $G - u - v$ is $(k-2)$-colourable. The only known double-critical $k$-chromatic graph is the complete $k$-graph $K_k$. The conjecture that there are no other double-critical graphs is a special case of...

  17. Double Modals as Single Lexical Items.

    Science.gov (United States)

    Di Paolo, Marianna

    1989-01-01

    Study of East and West Texans' (N=62) use of double modals as single lexical items and their syntactic and semantic characteristics found that neither Aux nor subcategorization analysis could account for both single-modal and double-modal dialects. Double modals, however, could conceivably be analyzed as two-word lexical items such as idioms or…

  18. The isotopic composition of zinc, palladium, silver, cadmium, tin, and tellurium in acid-etched residues of the Allende meteorite

    Energy Technology Data Exchange (ETDEWEB)

    Loss, R.D.; Rosman, K.J.R.; De Laeter, J.R. (Curtin Univ. of Technology, Perth (Australia))

    1990-12-01

    The isotopic and elemental abundances of Zn, Pd, Ag, Cd, Sn, and Te have been measured in three acid-resistant residues extracted from the Allende meteorite. High-efficiency, low-contamination ion-exchange procedures were developed to separate and purify the nanogram amounts of these elements present. Elemental-abundance determinations performed by Mass Spectrometric Isotope Dilution agree with previously published work for similarly derived residues. No isotope anomalies similar to those found for Xe (Xe-HL) in these samples were detected for any of these elements, which is consistent with the residues not being derived directly from the Xe-HL carriers. The lack of major Te-isotope anomalies does not support earlier reports of {sup 126}Te and {sup 130}Te excesses which were measured by neutron activation in similar samples. Small excesses were detected in the minor isotopes of Sn and Te, but these may be due to measurement problems associated with the small ion currents obtained for these samples. Two of the residue solutions contain Cd with up to several percent excesses for {sup 106}Cd and {sup 108}Cd. Interpretations of these results are limited by the unknown nature of the carrier minerals in the residues but may indicate the presence of a p-process component in Allende residues.

  19. [Effect of hydrofluoric acid etching time and resin bonding on the flexural strength of lithium disilicate glass ceramic].

    Science.gov (United States)

    Ren, Dong-feng; Luo, Xiao-ping

    2013-08-01

    To analyze the effect of hydrofluoric acid(HFA) etching time and resin bonding on the flexural strength of IPS e.max® Press glass ceramic, and evaluate the efficacy of resin cements to seal the cracks of the etched ceramic. Two hundred and twenty-five bars (25.0 mm×3.0 mm×2.0 mm) were made from IPS e.max® Press ingots using lost-wax, hot-pressed ceramic fabrication technology and randomly divided into five groups, forty-five each.In each group, the surfaces of ceramic bars were etched by 9.5% HFA gel for 0, 20, 40, 60 and 120 s respectively. Three specimens from each group were selected to observe the microstructure by the field emission scanning electron microscope (FE-SEM). Then each group were randomly subdivided into two subgroups (n = 20).One subgroup were coverd with a thin (approximately 0.1 mm) layer of resin cement (Variolink N), whereas the other subgroup remained unaltered.Half of the specimens were stored in 37°C water bath for 24 h and the other half went through thermocycle 10 000 times before 3-point bending test to determine their flexural strength.Interfaces between resin cement and etched ceramic were examined with FE-SEM. FE-SEM results showed that etching with HFA resulted in preferential dissolution of glass ceramic, and partially supported crystals within the glass matrix were lost with the increasing of etching time.FE-SEM indicated that resin cement sealed the cracks and defects and bonded tightly to etched ceramic surface. The mean flexural strength values of group 0, 20, 40, 60 and 120 s were (384 ± 33), (347 ± 43), (330 ± 53), (327 ± 67) , and (317 ± 41) MPa respectively. The mean flexural strength of each group except group 0 s increased significantly to (420 ± 31), (435 ± 50), (400 ± 39), and (412 ± 58) MPa respectively after the application of resin cement. Overtime HFA etching could have a wakening effect on IPS e.max® Press glass-ceramic. The application of dual-curing resin cement can compensate the strength loss of the etched glass ceramic.

  20. Shear bond strength between porcelain and nano filler composite resin with or without 9% hydrofluoric acid etching

    OpenAIRE

    Kun Ismiyatin

    2009-01-01

    Background: Reparation technique on restorations with broken or damaged porcelain which are still attached with the teeth are difficult, because it is very hard to remove the porcelain restoration without damaging it, and it needs a long time. Various ways have been developed to repair the broken porcelain, one of them is the use of composite resin as the material for the restoration of fractured porcelain. Repairing porcelain inside the mouth without removing the restoration of the damaged p...

  1. Comparative assessment of image quality for coronary CT angiography with iobitridol and two contrast agents with higher iodine concentrations: iopromide and iomeprol. A multicentre randomized double-blind trial

    Energy Technology Data Exchange (ETDEWEB)

    Achenbach, Stephan [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Department of Cardiology, Erlangen (Germany); Paul, Jean-Francois [Centre Chirurgical Marie Lannelongue, Department of Radiology, Le Plessis Robinson (France); Laurent, Francois [University of Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux (France); CHU de Bordeaux, Service d' Imagerie Thoracique et Cardiovasculaire, Pessac (France); Becker, Hans-Christoph [University Hospital Grosshadern, Department of Clinical Radiology, Munich (Germany); Rengo, Marco [Sapienza - University of Rome, ICOT Hospital, Department of Radiological Sciences, Oncology and Pathology, Latina (Italy); Caudron, Jerome [University Hospital of Rouen, Department of Radiology, Rouen (France); Leschka, Sebastian [Saint Gallen Hospital, Department of Radiology, Saint Gallen (Switzerland); Vignaux, Olivier [Cochin Hospital, Department of Radiology, Paris (France); Knobloch, Gesine [La Charite, Department of Radiology, Berlin (Germany); Benea, Giorgio [Ospedale del Delta, Ferrara (Italy); Schlosser, Thomas [Elisabeth-Krankenhaus Hospital, Essen (Germany); Andreu, Jordi [Hospital Vall d' Hebron, Barcelona (Spain); Cabeza, Beatriz [Hospital Clinico San Carlos, Madrid (Spain); Jacquier, Alexis [La Timone Adult Hospital, Department of Radiology, Marseille (France); Souto, Miguel [Complejo Hospitalario Universitario, Santiago de Compostela (Spain); Revel, Didier [Louis Pradel Hospital, Department of Radiology, Lyon (France); Qanadli, Salah Dine [University of Lausanne, Department of Radiology, Lausanne (Switzerland); Cademartiri, Filippo [Giovanni XXIII Hospital, Department of Radiology, Monastier di Treviso (Italy); Collaboration: X-ACT Study Group

    2017-02-15

    To demonstrate non-inferiority of iobitridol 350 for coronary CT angiography (CTA) compared to higher iodine content contrast media regarding rate of patients evaluable for the presence of coronary artery stenoses. In this multicentre trial, 452 patients were randomized to receive iobitridol 350, iopromide 370 or iomeprol 400 and underwent coronary CTA using CT systems with 64-detector rows or more. Two core lab readers assessed 18 coronary segments per patient regarding image quality (score 0 = non diagnostic to 4 = excellent quality), vascular attenuation, signal and contrast to noise ratio (SNR, CNR). Patients were considered evaluable if no segment had a score of 0. Per-patient, the rate of fully evaluable CT scans was 92.1, 95.4 and 94.6 % for iobitridol, iopromide and iomeprol, respectively. Non-inferiority of iobitridol over the best comparator was demonstrated with a 95 % CI of the difference of [-8.8 to 2.1], with a pre-specified non-inferiority margin of -10 %. Although average attenuation increased with higher iodine concentrations, average SNR and CNR did not differ between groups. With current CT technology, iobitridol 350 mg iodine/ml is not inferior to contrast media with higher iodine concentrations in terms of image quality for coronary stenosis assessment. (orig.)

  2. A placebo-controlled, double-blind, randomized, multicenter study to assess the effects of dronedarone 400 mg twice daily for 12 weeks on atrial fibrillation burden in subjects with permanent pacemakers.

    Science.gov (United States)

    Ezekowitz, Michael D; Ellenbogen, Kenneth A; DiMarco, John P; Kaszala, Karoly; Boddy, Alexander; Geba, Gregory P; P, Gregory Geba; Koren, Andrew

    2015-03-01

    Dronedarone is a benzofuran derivative with a pharmacological profile similar to amiodarone but has a more rapid onset of action and a much shorter half-life (13-19 h). Our goal was to evaluate the efficacy of dronedarone in atrial fibrillation (AF) patients using dual-chamber pacemakers capable of quantifying atrial fibrillation burden. Pacemakers were adjusted to optimize AF detection. Patients with AF burden >1% were randomized to dronedarone 400 mg twice daily (BID) or placebo. Pacemakers were interrogated after 4 and 12 weeks of treatment. The primary endpoint was the change in AF burden from baseline over the 12-week treatment period. Patients with permanent AF, severe/recently decompensated heart failure, and current use of antiarrhythmic drugs were excluded. AF burden was assessed by a core laboratory blinded to treatment assignment. From 285 patients screened, 112 were randomized (mean age 76 years, 60% male, 84% hypertensive, 65% with sick sinus syndrome, 26% with diabetes mellitus type II, 15% with heart failure). Baseline mean (SEM) AF burden was 8.77% (0.16) for placebo and 10.14% (0.17) for dronedarone. Over the 12-week study period, AF burden compared to baseline decreased by 54.4% (0.22) (P = 0.0009) with dronedarone and trended higher by 12.8% (0.16) (P = 0.450) with placebo. The absolute change in burden was decreased by 5.5% in the dronedarone group and increased by 1.1% in the placebo group. Heart rate during AF was reduced to approximately 4 beats/min with dronedarone (P = 0.285). Adverse events were higher with dronedarone compared to placebo (65 vs 56%). Dronedarone reduced pacemaker-assessed the relative AF burden compared to baseline and placebo by over 50% during the 12-week observation period.

  3. Experiments on double beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Busto, J. [Neuchatel Univ. (Switzerland). Inst. de Physique

    1996-11-01

    The Double Beta Decay, and especially ({beta}{beta}){sub 0{nu}} mode, is an excellent test of Standard Model as well as of neutrino physics. From experimental point of view, a very large number of different techniques are or have been used increasing the sensitivity of this experiments quite a lot (the factor of 10{sup 4} in the last 20 years). In future, in spite of several difficulties, the sensitivity would be increased further, keeping the interest of this very important process. (author) 4 figs., 5 tabs., 21 refs.

  4. Reconfigurable Double-Curved Mould

    DEFF Research Database (Denmark)

    Raun, Christian; Kirkegaard, Poul Henning

    2012-01-01

    , double curved surfaces like facades or walls, where the curvature of each element is relatively small in comparison to the overall shape. In the proposed dynamic mould system, where only a set of points is defined, a stiff membrane interpolates the surface between points. To function as a surface...... suitable for casting concrete or other substances against without the need for further manual treatment, the membrane should be durable and maintain a perfectly smooth and non-porous surface as well. A membrane with these properties has been developed for this project, and it is the core of the dynamic...

  5. Booster Double Harmonic Setup Notes

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. J. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.

    2015-02-17

    The motivation behind implementing a booster double harmonic include the reduced transverse space charge force from a reduced peak beam current and reduced momentum spread of the beam, both of which can be achieved from flattening the RF bucket. RF capture and acceleration of polarized protons (PP) is first set up in the single harmonic mode with RF harmonic h=1. Once capture and acceleration have been set up in the single harmonic mode, the second harmonic system is brought on and programmed to operate in concert with the single harmonic system.

  6. Combination of radiotherapy and double blockade HER2 with pertuzumab and trastuzumab for HER2-positive metastatic or locally recurrent unresectable and/or metastatic breast cancer: Assessment of early toxicity.

    Science.gov (United States)

    Ajgal, Z; de Percin, S; Diéras, V; Pierga, J Y; Campana, F; Fourquet, A; Kirova, Y M

    2017-04-01

    We evaluate the early toxicity of concurrent use of radiotherapy, pertuzumab and trastuzumab in patients with HER2-positive metastatic or locally recurrent unresectable breast cancer. A retrospective study was performed in a population of 23 consecutive patients between 2013 and 2015. Radiotherapy was performed on the chest area or metastatic sites during maintenance with pertuzumab and trastuzumab after six cycles of pertuzumab, trastuzumab and docetaxel. Toxicity was assessed according to the National Cancer Institute Common Toxicity Criteria version 4. Irradiation volumes were whole breast (8 patients) and chest wall (9 patients) at 50Gy in 25 fractions, the supraclavicular nodes (16 patients), the axillary area (nine patients) and the internal mammary nodes (9 patients) at 46Gy in 23 fractions. For five patients, radiotherapy was palliative: bone irradiation (4 patients), whole brain radiotherapy (one patient). Median follow-up was 12.6 months (range: 6.1-21.6 months) since the start of pertuzumab and trastuzumab. One patient presented an asymptomatic decrease of left ventricular ejection fraction below 50%. No symptomatic cardiac events were reported. Two patients presented asymptomatic grade I radiation pneumonitis. Acute skin toxicity was grade III (one patient), grade II (6 patients), and grade I (5 patients). There were two grade II esophagitis. Combination of pertuzumab, trastuzumab and radiotherapy was well tolerated, which should be confirmed by the results of larger studies. Copyright © 2017 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  7. Challenges in Double Beta Decay

    Directory of Open Access Journals (Sweden)

    Oliviero Cremonesi

    2014-01-01

    Full Text Available In the past ten years, neutrino oscillation experiments have provided the incontrovertible evidence that neutrinos mix and have finite masses. These results represent the strongest demonstration that the electroweak Standard Model is incomplete and that new Physics beyond it must exist. In this scenario, a unique role is played by the Neutrinoless Double Beta Decay searches which can probe lepton number conservation and investigate the Dirac/Majorana nature of the neutrinos and their absolute mass scale (hierarchy problem with unprecedented sensitivity. Today Neutrinoless Double Beta Decay faces a new era where large-scale experiments with a sensitivity approaching the so-called degenerate-hierarchy region are nearly ready to start and where the challenge for the next future is the construction of detectors characterized by a tonne-scale size and an incredibly low background. A number of new proposed projects took up this challenge. These are based either on large expansions of the present experiments or on new ideas to improve the technical performance and/or reduce the background contributions. In this paper, a review of the most relevant ongoing experiments is given. The most relevant parameters contributing to the experimental sensitivity are discussed and a critical comparison of the future projects is proposed.

  8. Dynamical Aspects of Electrostatic Double Layers

    DEFF Research Database (Denmark)

    Raadu, M.A.; Juul Rasmussen, J.

    1988-01-01

    Electrostatic double layers have been proposed as an acceleration mechanism in solar flares and other astrophysical objects. They have been extensively studied in the laboratory and by means of computer simulations. The theory of steady-state double layers implies several existence criteria...... plasma, at least for strong double layers, and it is argued that such conditions must be used with care when applied to real plasmas. Laboratory double layers, and by implication those arising in astrophysical plasmas often produce instabilities in the surrounding plasma and are generally time......-dependent structures. Naturally occuring double layers should, therefore, be far more common than the restrictions deduced from idealised time-independent models would imply. In particular it is necessary to understand more fully the time-dependent behaviour of double layers. In the present paper the dynamics of weak...

  9. Double Dirac cones in phononic crystals

    KAUST Repository

    Li, Yan

    2014-07-07

    A double Dirac cone is realized at the center of the Brillouin zone of a two-dimensional phononic crystal (PC) consisting of a triangular array of core-shell-structure cylinders in water. The double Dirac cone is induced by the accidental degeneracy of two double-degenerate Bloch states. Using a perturbation method, we demonstrate that the double Dirac cone is composed of two identical and overlapping Dirac cones whose linear slopes can also be accurately predicted from the method. Because the double Dirac cone occurs at a relatively low frequency, a slab of the PC can be mapped onto a slab of zero refractive index material by using a standard retrieval method. Total transmission without phase change and energy tunneling at the double Dirac point frequency are unambiguously demonstrated by two examples. Potential applications can be expected in diverse fields such as acoustic wave manipulations and energy flow control.

  10. SELECT-2: a Phase II, double-blind, randomised, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment for patients with advanced or metastatic non-small cell lung cancer.

    Science.gov (United States)

    Soria, J C; Fülöp, A; Maciel, C; Fischer, J R; Girotto, G; Lago, S; Smit, E; Ostoros, G; Eberhardt, W E E; Lishkovska, P; Lovick, S; Mariani, G; McKeown, A; Kilgour, E; Smith, P; Bowen, K; Kohlmann, A; Carlile, D J; Jänne, P A

    2017-10-03

    Combination of selumetinib plus docetaxel provided clinical benefit in a previous Phase II trial for patients with KRAS-mutant advanced non-small cell lung cancer (NSCLC). The Phase II SELECT-2 trial investigated safety and efficacy of selumetinib plus docetaxel for patients with advanced or metastatic NSCLC. Patients who had disease progression after first-line anti-cancer therapy were randomised (2:2:1) to selumetinib 75 mg BID plus docetaxel 60 mg/m2 or 75 mg/m2 (SEL+DOC 60; SEL+DOC 75), or placebo plus docetaxel 75 mg/m2 (PBO+DOC 75). Patients were initially enrolled independently of KRAS mutation status, but the protocol was amended to include only patients with centrally confirmed KRAS wild-type NSCLC. Primary endpoint was progression-free survival (PFS; RECIST 1.1); statistical analyses compared each selumetinib group with PBO+DOC 75 for KRAS wild-type and overall (KRAS mutant or wild-type) populations. 212 patients were randomised; 69% were KRAS wild-type. There were no statistically significant improvements in PFS or overall survival (OS) for overall or KRAS wild-type populations in either selumetinib group compared with PBO+DOC 75. Overall population median PFS for SEL+DOC 60, SEL+DOC 75 compared with PBO+DOC 75 was 3.0, 4.2 and 4.3 months, HRs: 1.12 (90% CI: 0.8, 1.61) and 0.92 (90% CI: 0.65, 1.31), respectively. In the overall population, a higher objective response rate (ORR; investigator assessed) was observed for SEL+DOC 75 (33%) compared with PBO+DOC 75 (14%); odds ratio: 3.26 (90% CI: 1.47, 7.95). Overall the tolerability profile of SEL+DOC was consistent with historical data, without new or unexpected safety concerns identified. The primary endpoint (PFS) was not met. The higher ORR with SEL+DOC 75 did not translating into prolonged PFS for the overall or KRAS wild-type patient populations. No clinical benefit was observed with SEL+DOC in KRAS wild-type patients compared with docetaxel alone. No unexpected safety concerns were reported

  11. Double row repair: is it worth the hassle?

    Science.gov (United States)

    Papalia, Rocco; Franceschi, Francesco; Del Buono, Angelo; Zampogna, Biagio; Maffulli, Nicola; Denaro, Vincenzo

    2011-12-01

    In the operative management of rotator cuff disease, comparable functional results have been reported after open or mini-open repair and arthroscopic fixation. Surgical repair aims to re-establish an anatomical configuration of the tendon-bone construct for restoring its mechanical performance. Single row repair is the most commonly used technique, but recently some authors have proposed to re-establish the rotator cuff footprint with 2 rows of suture anchors ("double row" repair). In regard to imaging assessment, at time zero double row repair results being more anatomic and allows for structurally sound restoration of the rotator cuff footprint. However, this does not seem to translate into superior clinical outcomes for the double row repair when evaluating all different sizes of rotator cuff tears as a whole. The scientific basis for recommending single or double row repair as preferred treatment for patients with rotator cuff tear is questionable, as minimal differences have been measured on clinical and functional rating scales.

  12. Optics design for CEPC double ring scheme

    Science.gov (United States)

    Wang, Yiwei; Su, Feng; Bai, Sha; Yu, Chenghui; Gao, Jie

    2017-12-01

    The CEPC is a future Circular Electron and Positron Collider proposed by China to mainly study the Higgs boson. Its baseline design is a double ring scheme and an alternative design is a partial double ring scheme. This paper will present the optics design for the main ring of the double ring scheme. The CEPC will also work as a W and Z factory. Compatible optics designs for a W and a Z modes will be presented as well.

  13. Evaluation of retention of pit and fissure sealants placed with and without air abrasion pretreatment in 6-8 year old children – An in vivo study

    Science.gov (United States)

    Goswami, Mridula

    2017-01-01

    Background The success of pit and fissure sealants is directly related to their retention. The purpose of this study was to assess and compare the retention of pit and fissure sealants placed using acid etch alone and a combination of air abrasion and acid etch techniques. Material and Methods 50 subjects aged 6-8 years were included in the study. Primary second molars and permanent first molars were sealed in all four quadrants using split mouth design. The right maxillary and mandibular molars (Group A) were treated by acid etching alone while the left maxillary and mandibular molars (Group B) were pretreated with air abrasion followed by acid etching before application of pit and fissure sealant. Retention of sealants was checked using Simonsen’s criteria of sealant retention after three and six months of sealant application. Results There was no significant difference in retention of sealants in Group A and Group B (psealant retention in primary and permanent molars was not significant (p>0.05). Maxillary molars showed superior retention compared to mandibular molars, which was statistically significant at both three and six months (psealant retention compared to acid etching alone in both primary and permanent molars after 3 and 6 months follow up. An additional air abrasion pretreatment step can be avoided in pediatric patients when placing sealants and the procedure can be completed faster with better behavior management using acid etching alone. Key words:Pit and fissure sealant, acid etching, air abrasion. PMID:28210438

  14. Evaluation of retention of pit and fissure sealants placed with and without air abrasion pretreatment in 6-8 year old children - An in vivo study.

    Science.gov (United States)

    Bhushan, Urvashi; Goswami, Mridula

    2017-02-01

    The success of pit and fissure sealants is directly related to their retention. The purpose of this study was to assess and compare the retention of pit and fissure sealants placed using acid etch alone and a combination of air abrasion and acid etch techniques. 50 subjects aged 6-8 years were included in the study. Primary second molars and permanent first molars were sealed in all four quadrants using split mouth design. The right maxillary and mandibular molars (Group A) were treated by acid etching alone while the left maxillary and mandibular molars (Group B) were pretreated with air abrasion followed by acid etching before application of pit and fissure sealant. Retention of sealants was checked using Simonsen's criteria of sealant retention after three and six months of sealant application. There was no significant difference in retention of sealants in Group A and Group B (psealant retention in primary and permanent molars was not significant (p>0.05). Maxillary molars showed superior retention compared to mandibular molars, which was statistically significant at both three and six months (psealant retention compared to acid etching alone in both primary and permanent molars after 3 and 6 months follow up. An additional air abrasion pretreatment step can be avoided in pediatric patients when placing sealants and the procedure can be completed faster with better behavior management using acid etching alone. Key words:Pit and fissure sealant, acid etching, air abrasion.

  15. Double Helix Nodal Line Superconductor

    Science.gov (United States)

    Sun, Xiao-Qi; Lian, Biao; Zhang, Shou-Cheng

    2017-10-01

    Time-reversal invariant superconductors in three dimensions may contain nodal lines in the Brillouin zone, which behave as Wilson loops of 3D momentum-space Chern-Simons theory of the Berry connection. Here we study the conditions of realizing linked nodal lines (Wilson loops), which yield a topological contribution to the thermal magnetoelectric coefficient that is given by the Chern-Simons action. We find the essential conditions are the existence of torus or higher genus Fermi surfaces and spiral spin textures. We construct such a model with two torus Fermi surfaces, where a generic spin-dependent interaction leads to double-helix-like linked nodal lines as the superconductivity is developed.

  16. CERN celebrates a double anniversary

    CERN Multimedia

    2003-01-01

    A symposium will celebrate the double anniversary of the observation of neutral currents in 1973 and the discovery of W and Z bosons in 1983. The symposium will also provide an opportunity to discuss future discoveries at CERN. The symposium will be held on 16 September in the Main Auditorium from 9:00 hrs and will be open to the public. If you cannot access the Main Auditorium, the symposium will be broadcast live in the following conference rooms: AB Auditorium II (Bldg 864) in Prévessin IT Auditorium (Bldg 31) AT Auditorium (Bldg 30) You can also follow it online with the Webcast accessible from the CERN home page. See the complete programme under Seminars.

  17. Double Helix Nodal Line Superconductor.

    Science.gov (United States)

    Sun, Xiao-Qi; Lian, Biao; Zhang, Shou-Cheng

    2017-10-06

    Time-reversal invariant superconductors in three dimensions may contain nodal lines in the Brillouin zone, which behave as Wilson loops of 3D momentum-space Chern-Simons theory of the Berry connection. Here we study the conditions of realizing linked nodal lines (Wilson loops), which yield a topological contribution to the thermal magnetoelectric coefficient that is given by the Chern-Simons action. We find the essential conditions are the existence of torus or higher genus Fermi surfaces and spiral spin textures. We construct such a model with two torus Fermi surfaces, where a generic spin-dependent interaction leads to double-helix-like linked nodal lines as the superconductivity is developed.

  18. Duration of erection: does it really matter? A randomized, double-blind clinical trial to assess the impact of vardenafil ODT on duration of erection and its correlation with patients' and partners' sexual quality of life and duration of intercourse: the VADEOPEN study.

    Science.gov (United States)

    Martin-Morales, Antonio; Gutiérrez-Hernández, Pedro; Romero-Otero, Javier; Romero-Martín, José A

    2014-06-01

    Stopwatch-assessed duration of erection has been proposed as an objective and reliable efficacy end point for erectile dysfunction (ED) treatments. The aim of this study is to assess vardenafil orodispersible tablets' (ODTs) efficacy in terms of duration of erection and (i) its correlation with other efficacy end points and male and female sexual quality of life (QoL) and (ii) its impact on intercourse duration. Randomized, double-blind, placebo-controlled, multicenter study comparing the efficacy and safety of vardenafil ODT 10 mg on-demand over 12 weeks in 127 patients with ED was carried out. Primary efficacy end points were stopwatch-assessed duration of erection (min) at any attempt and when leading to successful intercourse, and the erectile function domain of the International Index of Erectile Function (EF-IIEF) score. Secondary end points were sexual encounter profile (SEP) 3 response rate and male sexual QoL. End points in participating women (N = 46) were stopwatch-assessed duration of intercourse and sexual QoL. At week 12/last observation carried forward, patients taking vardenafil ODT had longer duration of erections (at any attempt or leading to successful intercourse) vs. placebo (least square mean ± standard error 10.2 ± 0.9 minutes vs. 7.9 ± 1.0 minutes, and 10.4 ± 0.8 vs. 8.3 ± 1.0 minutes, respectively), and significant increases in EF-IIEF scores, the SEP-3 response, and all sexual QoL items. An increased duration of intercourse was also observed. Female sexual QoL improved significantly. Both duration end points strongly correlated with EF-IIEF scores, and the three end points correlated well with SEP-3 response. Correlation was good with sexual QoL scores in men and women and with duration of intercourse, with differences between treatment groups only for duration end points. Safety was similar in both groups. This study provides further evidence for the consistency and reliability of the stopwatch-assessed

  19. Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures.

    Science.gov (United States)

    Maria, Sifat; Swanson, Mark H; Enderby, Larry T; D'Amico, Frank; Enderby, Brianna; Samsonraj, Rebekah M; Dudakovic, Amel; van Wijnen, Andre J; Witt-Enderby, Paula A

    2017-01-26

    This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral density (BMD) and quality of life (QOL) in postmenopausal osteopenic women (ages 49-75). Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%), with an upward trend for total left hip (p=0.069). MSDK increased serum P1NP levels and reduced bone turnover (CTx:P1NP). Psychometric analyses indicated that mood and sleep quality improved for the MSDK group. MSDK-exposed human mesenchymal stem cells (hMSCs) and human peripheral blood monocytes (hPBMCs) plated in transwells or layered demonstrated increases in osteoblastogenesis, decreases in osteoclastogenesis, increases in OPG (TNFRSF11B) and decreases in RANKL (TNFSF11) levels. In transwell osteoblasts, MSDK increased pERK1/2 (MAPK1/MAPK3) and RUNX2 levels; decreased ERK5 (MAPK7); and did not affect the expression of NFκB (NFKB1) and β1integrin (ITGB1). In layered osteoblasts, MSDK also decreased expression of the metabolic proteins PPARγ (PPARG) and GLUT4 (SLC2A4). In adipose-derived human MSCs, MSDK induced osteoblastogenesis. These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis or other bone-related diseases.

  20. Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular hospitalization or death from any cause in PatiENts with atrial fibrillation/atrial flutter

    DEFF Research Database (Denmark)

    Hohnloser, S.H.; Connolly, S.J.; Crijns, H.J.G.M.

    2008-01-01

    Rationale and Design of ATHENA. Background: Atrial fibrillation (AF) is the most commonly encountered clinical arrhythmia, predominantly affecting elderly patients. There is a continued need for new antiarrhythmic drugs to treat the ever-increasing number of patients with this arrhythmia. Droneda......Rationale and Design of ATHENA. Background: Atrial fibrillation (AF) is the most commonly encountered clinical arrhythmia, predominantly affecting elderly patients. There is a continued need for new antiarrhythmic drugs to treat the ever-increasing number of patients with this arrhythmia....... Dronedarone is a new antiarrhythmic compound currently being developed for treatment of AF. Methods: The ATHENA trial (A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in pati...... hospitalization or death from any cause. The study has completed patient enrollment in December 2006 and is expected to end follow-up 1 year later. Conclusion: ATHENA will be the largest efficacy and safety trial of dronedarone, a multichannel blocker compound with properties from class I, II, III, and IV...

  1. Socially Disadvantaged Students in Socially Disadvantaged Schools: Double Jeopardy in Mathematics Achievement in the G8 Countries

    Science.gov (United States)

    Dundas, Traci Lynne

    2010-01-01

    Using the G8 countries' (Canada, France, Germany, Italy, Japan, the Russian Federation, the United Kingdom, and the United States) samples from the 2003 Programme for International Student Assessment (PISA), this study aimed to explore the phenomenon of double jeopardy in mathematics achievement for socially disadvantaged students. Double jeopardy…

  2. Double meanings will not save the principle of double effect.

    Science.gov (United States)

    Douglas, Charles D; Kerridge, Ian H; Ankeny, Rachel A

    2014-06-01

    In an article somewhat ironically entitled "Disambiguating Clinical Intentions," Lynn Jansen promotes an idea that should be bewildering to anyone familiar with the literature on the intention/foresight distinction. According to Jansen, "intention" has two commonsense meanings, one of which is equivalent to "foresight." Consequently, questions about intention are "infected" with ambiguity-people cannot tell what they mean and do not know how to answer them. This hypothesis is unsupported by evidence, but Jansen states it as if it were accepted fact. In this reply, we make explicit the multiple misrepresentations she has employed to make her hypothesis seem plausible. We also point out the ways in which it defies common sense. In particular, Jansen applies her thesis only to recent empirical research on the intentions of doctors, totally ignoring the widespread confusion that her assertion would imply in everyday life, in law, and indeed in religious and philosophical writings concerning the intention/foresight distinction and the Principle of Double Effect. © The Author 2014. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Finite difference order doubling in two dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Killingbeck, John P [Mathematics Centre, University of Hull, Hull HU6 7RX (United Kingdom); Jolicard, Georges [Universite de Franche-Comte, Institut Utinam (UMR CNRS 6213), Observatoire de Besancon, 41 bis Avenue de l' Observatoire, BP1615, 25010 Besancon cedex (France)

    2008-03-28

    An order doubling process previously used to obtain eighth-order eigenvalues from the fourth-order Numerov method is applied to the perturbed oscillator in two dimensions. A simple method of obtaining high order finite difference operators is reported and an odd parity boundary condition is found to be effective in facilitating the smooth operation of the order doubling process.

  4. Double Chooz and Reactor Theta13 Experiments

    CERN Document Server

    ,

    2016-01-01

    This is a contribution paper from the Double Chooz experiment to the special issue of NPB on neutrino oscillations. The physics and history of the reactor theta13 experiments, as well as Double Chooz experiment and its neutrino oscillation analyses are reviewed.

  5. Modelling the formation of double white dwarfs

    NARCIS (Netherlands)

    van der Sluijs, M.V.; Verbunt, F.W.M.|info:eu-repo/dai/nl/068970374; Pols, O.|info:eu-repo/dai/nl/111811155

    2006-01-01

    We investigate the formation of the ten double-lined double white dwarfs that have been observed so far. A detailed stellar evolution code is used to calculate grids of single-star and binary models and we use these to reconstruct possible evolutionary scenarios. We apply various criteria to select

  6. The homozygosity verification for doubled haploid Japanese ...

    African Journals Online (AJOL)

    ELOHO

    2012-09-18

    Sep 18, 2012 ... coefficients of variation of doubled haploids were significantly higher than those of normal diploids. Key words: Doubled haploids, gynogenesis, Japanese flounder, Paralichthys olivaceus. INTRODUCTION. Mitotic gynogenesis in fish has been used to produce completely homozygous progenies (Thorgaad ...

  7. 7 CFR 3560.460 - Double damages.

    Science.gov (United States)

    2010-01-01

    ... DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Special Servicing, Enforcement, Liquidation, and Other Actions § 3560.460 Double damages. (a) Action to recover assets or income. (1) The Agency may request to... 7 Agriculture 15 2010-01-01 2010-01-01 false Double damages. 3560.460 Section 3560.460 Agriculture...

  8. Double pulse Thomson scattering system at RTP

    NARCIS (Netherlands)

    Beurskens, M. N. A.; Barth, C. J.; Chu, C.C.; Donne, A. J. H.; Herranz, J. A.; Cardozo, N. J. L.; van der Meiden, H. J.; Pijper, F.J.

    1997-01-01

    In this article a double pulse multiposition Thomson scattering diagnostic, under construction at RTP, is discussed. Light from a double pulsed ruby laser (pulse separation: 10-800 mu s, max. 2x12.5 J) is scattered by the free electrons of the tokamak plasma and relayed to a Littrow polychromator

  9. Intrateam Communication and Performance in Doubles Tennis

    Science.gov (United States)

    Lausic, Domagoj; Tennebaum, Gershon; Eccles, David; Jeong, Allan; Johnson, Tristan

    2009-01-01

    Verbal and nonverbal communication is a critical mediator of performance in team sports and yet there is little extant research in sports that involves direct measures of communication. Our study explored communication within NCAA Division I female tennis doubles teams. Video and audio recordings of players during doubles tennis matches captured…

  10. Three Dimensional Double Layers in Magnetized Plasmas

    DEFF Research Database (Denmark)

    Jovanovic, D.; Lynov, Jens-Peter; Michelsen, Poul

    1982-01-01

    Experimental results are presented which demonstrate the formation of fully three dimensional double layers in a magnetized plasma. The measurements are performed in a magnetized stationary plasma column with radius 1.5 cm. Double layers are produced by introducing an electron beam with radius 0...

  11. The Sexual Double Standard: How Prevalent Today?

    Science.gov (United States)

    Sack, Alan R.; And Others

    1981-01-01

    Studied the sexual double standard among university students. Females showed a stronger association between premarital intercourse and affection and perceived less approval from five reference groups for their sexual behavior than did males. Results indicate the sexual double standard is still evident among the present group of college students.…

  12. The Doubling Moment: Resurrecting Edgar Allan Poe

    Science.gov (United States)

    Minnick, J. Bradley; Mergil, Fernando

    2008-01-01

    This article expands upon Jeffrey Wilhelm's and Brian Edmiston's (1998) concept of a doubling of viewpoints by encouraging middle level students to use dramatization to take on multiple perspectives, to pose interpretive questions, and to enhance critical inquiry from inside and outside of texts. The doubling moment is both the activation of…

  13. Reliability Estimation for Double Containment Piping

    Energy Technology Data Exchange (ETDEWEB)

    L. Cadwallader; T. Pinna

    2012-08-01

    Double walled or double containment piping is considered for use in the ITER international project and other next-generation fusion device designs to provide an extra barrier for tritium gas and other radioactive materials. The extra barrier improves confinement of these materials and enhances safety of the facility. This paper describes some of the design challenges in designing double containment piping systems. There is also a brief review of a few operating experiences of double walled piping used with hazardous chemicals in different industries. This paper recommends approaches for the reliability analyst to use to quantify leakage from a double containment piping system in conceptual and more advanced designs. The paper also cites quantitative data that can be used to support such reliability analyses.

  14. Agreement, dominance and doubling : the morphosyntax of DP

    NARCIS (Netherlands)

    Schoorlemmer, Erik

    2009-01-01

    This thesis investigates doubling and agreement in Romance and Germanic nominal constituents. In Swedish, Norwegian, and Faroese, the definite article is doubled in case an adjective modifies the noun. This doubling is known as double definiteness. This thesis proposes that double definiteness is

  15. Double layers in contactor plasmas

    Science.gov (United States)

    Cooke, David L.

    1990-01-01

    The concept of using a hollow cathode to establish a low impedance contact between a spacecraft and the ambient plasma continues to gain in popularity, and is often then referred to as a plasma contactor. A growing number of studies indicate that large contact currents can be supported with small potential difference between the contactor and the ambient plasma. Results will be presented from a simple one-dimensional spherical model that obtains potentials from the solution of Poisson's equation, and particle densities from a turning point formalism that includes particle angular momentum. The neglect of collisions and magnetic field limits the realism. However, the results illustrate the effect of double layers that can form at the interface between contactor and ambient plasmas, when there is any voltage differential between the contactor and the ambient. The I-V characteristic of this model shows the usual space charge depends upon collection when the contactor flux is lower than some threshold; independence of I from variation in V when the flux is slightly greater than that threshold, and (numerical ?) instability for excessive flux suggesting the possibility of negative resistance. Even if a real I-V characteristic does not exhibit negative resistance, flat spots or high resistance regions may still be troublesome (or useful) to the total circuit.

  16. Contact double-contrast cholangiography.

    Science.gov (United States)

    Hishida, Y

    1979-05-01

    Recently operative cholangiography has become an essential step in biliary surgery. However, an usual technique in which x-ray film is set beneath the patient has its limitation in visualization of fine changes. The author devised a new technique to resolve this problem. A triangular mammography film designed for good positioning is vaccum-packed, coupled with an intensifying screen of the same size, and then is sterilized in advance. Barium solution mixed with Gascon drop (a defoaming agent) is used as contrast material. The duodenum and head of the pancreas are mobilized. Usual cholangiography is performed at first, introducing angiographic media through a catheter placed into the catheter placed into the common duct via the cystic duct. After this study a triangle film pack is set beneath the second part of the duodenum. Two to three milliliters of barium, 1 to 2 ml of Gascon, and 15 ml of air are pushed in; thus a contact double-contrast cholangiogram is obtained. This technique promises clear demonstration of the distal bile duct without risk, and even fine mucosal plicae may be discernible in the film.

  17. Renormalization of minimally doubled fermions

    Science.gov (United States)

    Capitani, Stefano; Creutz, Michael; Weber, Johannes; Wittig, Hartmut

    2010-09-01

    We investigate the renormalization properties of minimally doubled fermions, at one loop in perturbation theory. Our study is based on the two particular realizations of Boriçi-Creutz and Karsten-Wilczek. A common feature of both formulations is the breaking of hyper-cubic symmetry, which requires that the lattice actions are supplemented by suitable counterterms. We show that three counterterms are required in each case and determine their coefficients to one loop in perturbation theory. For both actions we compute the vacuum polarization of the gluon. It is shown that no power divergences appear and that all contributions which arise from the breaking of Lorentz symmetry are cancelled by the counterterms. We also derive the conserved vector and axial-vector currents for Karsten-Wilczek fermions. Like in the case of the previously studied Boriçi-Creutz action, one obtains simple expressions, involving only nearest-neighbour sites. We suggest methods how to fix the coefficients of the counterterms non-perturbatively and discuss the implications of our findings for practical simulations.

  18. Treatment Assignment Guesses by Study Participants in a Double-Blind Dose Escalation Clinical Trial of Saw Palmetto

    OpenAIRE

    Lee, Jeannette Y.; Moore, Page; Kusek, John; Barry, Michael

    2014-01-01

    Objectives: This report assesses participant perception of treatment assignment in a randomized, double-blind, placebo-controlled trial of saw palmetto for the treatment of benign prostatic hyperplasia (BCM).

  19. Intrathecal baclofen in children with spastic cerebral palsy: a double-blind, randomized, placebo-controlled, dose-finding study

    National Research Council Canada - National Science Library

    Hoving, Marjanke A; van Raak, Elisabeth P M; Spincemaille, Geert H J J; Palmans, Liesbeth J; Sleypen, Frans A M; Vles, Johan S H

    2007-01-01

    ...). The aims of this double-blind, randomized, placebo-controlled, dose-finding study were to select children eligible for continuous ITB infusion, to assess the effective ITB bolus dose, and to evaluate...

  20. Indefinite Determiner Doubling: Data and Methods

    DEFF Research Database (Denmark)

    Wood, Johanna; Vikner, Sten

    2017-01-01

    , and double definiteness, found in some Scandinavian languages. In this chapter, we focus on doubling of indefinite determiners in the Germanic languages, that is, on nominal expressions in which the indefinite article occurs more than once within the same DP (determiner phrase, i.e. nominal expression).......Syntactic doubling, expressing a constituent twice (or more) when a single occurrence should suffice, is surprisingly common, especially where functional elements are concerned (Barbiers 2008:5). Some well-known examples include multiple negation/negative concord, found in many languages...

  1. Double-reed exhaust valve engine

    Science.gov (United States)

    Bennett, Charles L.

    2015-06-30

    An engine based on a reciprocating piston engine that extracts work from pressurized working fluid. The engine includes a double reed outlet valve for controlling the flow of low-pressure working fluid out of the engine. The double reed provides a stronger force resisting closure of the outlet valve than the force tending to open the outlet valve. The double reed valve enables engine operation at relatively higher torque and lower efficiency at low speed, with lower torque, but higher efficiency at high speed.

  2. The Dissolution of Double Holliday Junctions

    DEFF Research Database (Denmark)

    Bizard, Anna H; Hickson, Ian D

    2014-01-01

    as "double Holliday junction dissolution." This reaction requires the cooperative action of a so-called "dissolvasome" comprising a Holliday junction branch migration enzyme (Sgs1/BLM RecQ helicase) and a type IA topoisomerase (Top3/TopoIIIα) in complex with its OB (oligonucleotide/oligosaccharide binding......Double Holliday junctions (dHJS) are important intermediates of homologous recombination. The separate junctions can each be cleaved by DNA structure-selective endonucleases known as Holliday junction resolvases. Alternatively, double Holliday junctions can be processed by a reaction known...

  3. Doubling left syntactic positions in Danish

    DEFF Research Database (Denmark)

    Jørgensen, Henrik

    2016-01-01

    This paper deals with the doubling of left syntactic positions in Danish. Such doublings consist of a referential element: a NP or a clause, and an anaphoric element, an unstressed personal pronoun or an unstressed resumptive adverb. In main clauses, the CP-spec position may double in this way, w...... in the analysis of a broadcasted public speech (sect. 5). In earlier versions of Danish, as shown in sect. 4, the construction is both more frequent in writing and also seems almost obligatory....

  4. Positivity bounds on double parton distributions

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus; Kasemets, Tomas

    2013-03-15

    Double hard scattering in proton-proton collisions is described in terms of double parton distributions. We derive bounds on these distributions that follow from their interpretation as probability densities, taking into account all possible spin correlations between two partons in an unpolarized proton. These bounds constrain the size of the polarized distributions and can for instance be used to set upper limits on the effects of spin correlations in double hard scattering. We show that the bounds are stable under leading-order DGLAP evolution to higher scales.

  5. Assessment of the effeCt of lIfestyle iNtervention plus water-soluble ciNnAMon extract On loweriNg blood glucose in pre-diabetics, a randomized, double-blind, multicenter, placebo controlled trial: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Crawford, Paul; Thai, Chuong; Obholz, Joshua; Schievenin, Jeffrey; True, Mark; Shah, Sachin A; Hallgren, John; Clark, Jill; Sharon, Danny

    2016-01-05

    The World Health Organization predicts that by 2030 diabetes will be the seventh leading cause of death in the world. Multiple studies have tried to determine if cinnamon is an effective treatment for diabetes. Cinnamon extract is an insulin sensitizer, protects mesangial cells, decreases inflammatory markers, and lowers glucose, lipids, and blood pressure in patients with type 2 diabetes, so we developed a protocol to study whether ingestion of water-soluble cinnamon extract prevents progression from pre-diabetes to diabetes. This is a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in subjects with pre-diabetes who have committed to participate in a lifestyle change program. The trial will be conducted at five sites and will include 428 subjects who take cinnamon extract or placebo for 1 year. Follow-up for these subjects will be for a total of 2 years (nine study visits). The primary outcomes to be assessed are 1) conversion of patients from pre-diabetes to diabetes and 2) impact of water-soluble cinnamon extract on hepatic transaminases, renal function, and QT interval on electrocardiogram. Secondary outcomes include changes in HbA1c, lipids, waist circumference, weight, blood pressure, and fasting plasma glucose. The trial protocol has been approved by the Institutional Review Board of the US Air Force 59th Medical Wing, Wilford Hall Ambulatory Surgical Center (Protocol FWH20110035H). Investigator-sponsored Investigational New Drug status (114078) was granted by the US Food and Drug Administration. This study will provide high-quality evidence of the efficacy of water-soluble cinnamon extract in conjunction with lifestyle intervention for preventing patients with pre-diabetes from converting to diabetes. Additionally, it will provide important safety information about water-soluble cinnamon extract. ClinicalTrials.gov Identifier: NCT01301521 , 18 February 2011.

  6. Post-prandial reflux suppression by a raft-forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH-impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double-blind study in reflux patients.

    Science.gov (United States)

    Sweis, R; Kaufman, E; Anggiansah, A; Wong, T; Dettmar, P; Fried, M; Schwizer, W; Avvari, R K; Pal, A; Fox, M

    2013-06-01

    Alginates form a raft above the gastric contents, which may suppress gastro-oesophageal reflux; however, inconsistent effects have been reported in mechanistic and clinical studies. To visualise reflux suppression by an alginate-antacid [Gaviscon Advance (GA), Reckitt Benckiser, UK] compared with a nonraft-forming antacid using magnetic resonance imaging (MRI), and to determine the feasibility of pH-impedance monitoring for assessment of reflux suppression by alginates. Two studies were performed: (i) GA and antacid (Alucol, Wander Ltd, Switzerland) were visualised in the stomach after ingestion in 12 healthy volunteers over 30 min after a meal by MRI, with reflux events documented by manometry. (ii) A randomised controlled, double-blind cross-over trial of post-prandial reflux suppression documented by pH-impedance in 20 patients randomised to GA or antacid (Milk of Magnesia; Boots, UK) after two meals taken 24 h apart. MRI visualized a "mass" of GA form at the oesophago-gastric junction (OGJ); simple antacid sank to the distal stomach. The number of post-prandial common cavity reflux events was less with GA than antacid [median 2 (0-5) vs. 5 (1-11); P pH-impedance were similar after GA and antacid. There was a trend to reduced proximal reflux events with GA compared with antacid [10.5 (8.9) vs. 13.9 (8.3); P = 0.070]. Gaviscon Advance forms a 'mass' close to the OGJ and significantly suppresses reflux compared with a nonraft-forming antacid. Standard pH-impedance monitoring is suitable for clinical studies of GA in gastro-oesophageal reflux disease patients where proximal reflux is the primary outcome. © 2013 Blackwell Publishing Ltd.

  7. Application of double-layered skin phantoms for optical flow imaging during laser tattoo treatments

    Science.gov (United States)

    Lee, Byeong-il; Song, Woosub; Kim, Hyejin; Kang, Hyun Wook

    2016-05-01

    The feasible application of double-layered skin phantoms was evaluated to identify artificial blood flow with a Doppler optical coherence tomography (DOCT) system for laser tattoo treatments. Polydimethylsiloxane (PDMS) was used to fabricate the artificial phantoms with flow channels embedded. A double-integrating sphere system with an inverse adding-doubling method quantified both the absorption and the reduced scattering coefficients for epidermis and dermis phantoms. Both OCT and caliper measurements confirmed the double-layered phantom structure (epidermis = 136 ± 17 µm vs. dermis = 3.0 ± 0.1 mm). The DOCT method demonstrated that high flow rates were associated with high image contrast, visualizing the position and the shape of the flow channel. Application of the channel-embedded skin phantoms in conjunction with DOCT can be a reliable technique to assess dynamic variations in the blood flow during and after laser tattoo treatments.

  8. Rationale, design, and baseline characteristics of the Study assessInG the morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIFY trial): a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease without clinical heart failure.

    Science.gov (United States)

    Fox, Kim; Ford, Ian; Steg, Philippe Gabriel; Tardif, Jean-Claude; Tendera, Michal; Ferrari, Roberto

    2013-10-01

    Elevated heart rate in stable coronary artery disease (CAD) is associated with worse outcomes, particularly increased risk of myocardial infarction. Heart rate reduction with the If inhibitor ivabradine confers symptomatic benefits in angina pectoris and reduces coronary events in patients with stable CAD and left ventricular (LV) systolic dysfunction, with a resting heart rate of ≥70 beats/min. The SIGNIFY trial is testing the hypothesis that heart rate reduction using ivabradine reduces mortality and cardiovascular events in patients with stable CAD, but without clinical heart failure. The SIGNIFY trial is a randomized, double-blind, parallel-group, placebo-controlled, event-driven study in patients with stable CAD (1,139 centers, 51 countries). Participants are 55 years or older, with stable CAD and an LV ejection fraction >40%, in sinus rhythm, with a baseline resting heart rate of ≥70 beats/min, and with at least 1 additional cardiovascular risk factor. At inclusion, patients receive ivabradine 7.5 mg twice a day or matching placebo, which is adjusted at every visit to a heart rate target of 60 beats/min. Participants should receive the best possible background treatment for stable CAD. The primary end point is a composite of cardiovascular death or nonfatal myocardial infarction. Recruitment lasted from October 2009 to April 2012. The SIGNIFY trial has recruited 19,102 patients (age 65.0 ± 7.2 years, resting heart rate 77.2 ± 7.0 beats/min, 72% male) with no evidence for LV dysfunction (ejection fraction 56.5% ± 8.6%). The SIGNIFY trial will shed further light on the role of heart rate lowering with ivabradine in patients with stable CAD without clinical heart failure. The study is expected to end in 2014. © 2013.

  9. On Double-Star Decomposition of Graphs

    Directory of Open Access Journals (Sweden)

    Akbari Saieed

    2017-08-01

    Full Text Available A tree containing exactly two non-pendant vertices is called a double-star. A double-star with degree sequence (k1 + 1, k2 + 1, 1, . . . , 1 is denoted by Sk1,k2. We study the edge-decomposition of graphs into double-stars. It was proved that every double-star of size k decomposes every 2k-regular graph. In this paper, we extend this result by showing that every graph in which every vertex has degree 2k + 1 or 2k + 2 and containing a 2-factor is decomposed into Sk1,k2 and Sk1−1,k2, for all positive integers k1 and k2 such that k1 + k2 = k.

  10. 32 CFR 199.8 - Double coverage.

    Science.gov (United States)

    2010-07-01

    ... from the operation of a motor vehicle. (4) Exceptions. Double coverage plans do not include: (i) Plans... (for example, the Indian Health Service); or (v) State Victims of Crime Compensation Programs. (c...

  11. Period doubling patterns of interval maps

    CERN Document Server

    Valaristos, A

    2003-01-01

    We prove the existence and demonstrate the construction of period doubling patterns centered at periodic orbits of continuous maps on the interval. In particular we prove that f in R: =set membership C sup 0 (I,I) exhibits a period doubling pattern centered at a fixed point of f if and only if the set of periodic points is not closed. Furthermore, we prove that if f has a periodic orbit of period n>1, which is not a power of two, and n .pr. m in Sarkovskii's ordering, then f exhibits a period doubling pattern centered at a periodic orbit of period m. An analytic configuration of such period doubling patterns is exhibited.

  12. Over-under double-pass interferometer

    Science.gov (United States)

    Schindler, Rudolf A. (Inventor)

    1980-01-01

    An over-under double-pass interferometer in which the beamsplitter area and thickness can be reduced to conform only with optical flatness considerations is achieved by offsetting the optical center line of one cat's-eye retroreflector relative to the optical center line of the other in order that one split beam be folded into a plane distinct from the other folded split beam. The beamsplitter is made transparent in one area for a first folded beam to be passed to a mirror for doubling back and is made totally reflective in another area for the second folded beam to be reflected to a mirror for doubling back. The two beams thus doubled back are combined in the central, beam-splitting area of the beamsplitter and passed to a detector. This makes the beamsplitter insensitive to minimum-thickness requirements and selection of material.

  13. Clitic doubling and pure agreement person features

    Directory of Open Access Journals (Sweden)

    Ricardo Machado Rocha

    2016-03-01

    Full Text Available In this paper, we analyze clitic doubling constructions in dialectal non-standard Brazilian Portuguese. Within the Minimalism Framework, we explain very peculiar aspects of the doubled structures in this language, namely the fact that they occur only for 1st and 2nd person pronouns and that they co-vary with single clitic structures and single strong pronoun structures. Our approach assumes that the clitics me and te are hosted by a dedicated functional projection and result from the checking of the sole person feature [speaker:±]. Moreover, we show that, unlikely other cross-linguistic phenomena of pronominal doubling, Brazilian Portuguese Clitic Doubling does neither yield (nor is a result of any interpretive effect, but rather is an instance of a pure agreement chain. This leads us to advocate, contra the standard Minimalist Program, for the validity of the conceptual postulation of AgrP, as a condition on well-formedness of certain structures.

  14. Double Heavy Flavour Production at LHCb

    CERN Document Server

    Li, Yiming

    2017-01-01

    This proceeding summarises the latest LHCb results on associated heavy flavour productions, including double charm production and associated bottomonia and charm production. This article belongs to the Topical Collection “New Observables in Quarkonium Production”.

  15. Rosalind Franklin and the Double Helix

    Science.gov (United States)

    Elkin, Lynne Osman

    2003-03-01

    Although she made essential contributions toward elucidating the structure of DNA, Rosalind Franklin is known to many only as seen through the distorting lens of James Watson's book, The Double Helix.

  16. A High Power Frequency Doubled Fiber Laser

    Science.gov (United States)

    Thompson, Rob; Tu, Meirong; Aveline, Dave; Lundblad, Nathan; Maleki, Lute

    2003-01-01

    This slide presentation reviews the power frequencies for the doubled fiber laser. It includes information on the 780 nm laser, second harmonic generation in one crystal, cascading crystals, the tenability of laser systems, laser cooling, and directions for future work.

  17. Forensic testing of a double tee bridge.

    Science.gov (United States)

    2014-12-01

    This report describes an investigation to quantify the behavior of precast, prestressed concrete double-tee bridge : girders made with lightweight concrete. As part of the investigation, three bridge girders were salvaged from a : decommissioned brid...

  18. Inverse solutions for tilting orthogonal double prisms.

    Science.gov (United States)

    Li, Anhu; Ding, Ye; Bian, Yongming; Liu, Liren

    2014-06-10

    An analytical reverse solution and actual examples are given to show how to direct a laser beam from a pair of orthogonal prisms to given targets in free space. Considering the influences of double-prism structural parameters, a lookup table method to seek the numerical reverse solution of each prism's tilting angle is also proposed for steering the double-prism orientation to track a target position located in the near field. Some case studies, as well as a specified elliptical target trajectory scanned by the cam-based driving double prisms, exhibit the significant application values of the theoretical derivation. The analytic reverse and numerical solutions can be generalized to investigate the synthesis of scanning patterns and the controlling strategy of double-prism tilting motion, the potentials of which can be explored to perform the orientation and position tracking functions in applications of precision engineering fields.

  19. On the distribution of visual double stars

    Directory of Open Access Journals (Sweden)

    Angelov T.

    1998-01-01

    Full Text Available An integrated distribution function is derived for visual double stars according to the magnitude difference Δm between the components. For this purpose the author uses a sample of 1626 double stars with Δm ∈ [0m − 4m]. The increment of the descriptive distribution function for an arbitrary increment of the variable Δm is also determined.

  20. Conserved currents of double field theory

    Energy Technology Data Exchange (ETDEWEB)

    Blair, Chris D.A. [Department of Applied Mathematics and Theoretical Physics,Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)

    2016-04-29

    We find the conserved current associated to invariance under generalised diffeomorphisms in double field theory. This can be used to define a generalised Komar integral. We comment on its applications to solutions, in particular to the fundamental string/pp-wave. We also discuss the current in the context of Scherk-Schwarz compactifications. We calculate the current for both the original double field theory action, corresponding to the NSNS sector alone, and for the RR sector.

  1. Double parton scatterings at the CERN LHC

    CERN Document Server

    Del Fabbro, R

    2001-01-01

    Double parton collisions give important effects at the LHC and not only in the QCD sector. Given the relatively low threshold and the consequent large rate of production of bb pairs, one expects a large background of double parton collisions to the Higgs boson production and decay via the bbW channel, which is one of the most promising discovery channels at the LHC, if the Higgs mass is below the W/sup + /W/sup -/ threshold. (15 refs).

  2. Oat Doubled Haploids Following Maize Pollination.

    Science.gov (United States)

    Davies, Philip A; Sidhu, Parminder K

    2017-01-01

    Doubled haploids (DHs) are an important tool for the accelerated production of new crop varieties. In oat, DHs were first produced by pollinating oat florets with maize pollen. The resultant embryos spontaneously eliminate the maize chromosomes leaving a haploid complement of oat chromosomes. These embryos can be cultured in vitro using the "embryo rescue" technique to produce haploid plants whose chromosome number can be doubled with colchicine to produce homozygous DH oat plants.

  3. Double Marginalisation Effect Within Logistics Chain

    OpenAIRE

    Drago Pupavac

    2008-01-01

    Double marginalization occurs in vertical industries when both the upstream and downstream firms have monopoly power. Each firm reduces output from the competitive level to the monopoly level,creating two deadweight losses. This market myopia creates a "vertical externality" that vertical integration would internalize. In order to prove the hypothesis about building strategic partnership and collaboration as a way to remove the effect of double marginalization we have been focused on the rese...

  4. Early Results of Anatomic Double Bundle Anterior Cruciate Ligament Reconstruction

    Directory of Open Access Journals (Sweden)

    Demet Pepele

    2014-03-01

    Full Text Available Aim: The goal in anterior cruciate ligament reconstruction (ACLR is to restore the normal anatomic structure and function of the knee. In the significant proportion of patients after the traditional single-bundle ACLR, complaints of instability still continue. Anatomic double bundle ACLR may provide normal kinematics in knees, much closer to the natural anatomy. The aim of this study is to clinically assess the early outcomes of our anatomical double bundle ACLR. Material and Method: In our clinic between June 2009 and March 2010, performed the anatomic double bundle ACLR with autogenous hamstring grafts 20 patients were evaluated prospectively with Cincinnati, IKDC and Lysholm scores and in clinically for muscle strength and with Cybex II dynamometer. Results: The mean follow-up is 17.8 months (13-21 months. Patients%u2019 scores of Cincinnati, IKDC and Lysholm were respectively, preoperative 18.1, 39.3 and 39.8, while the post-op increased to 27.2, 76.3 and 86.3. In their last check, 17 percent of the patients according to IKDC scores (85% A (excellent and B (good group and 3 patients took place as C (adequate group. The power measurements of quadriceps and hamstring muscle groups of patients who underwent surgery showed no significant difference compared with the intact knees. Discussion: Double-bundle ACL reconstruction is a satisfactory method. There is a need comparative, long-term studies in large numbers in order to determine improving clinical outcome, preventing degeneration and restoring the knee biomechanics better.

  5. The sexual double standard and risk taking among young adults

    OpenAIRE

    Almeida, Ricardo Alvim da Costa Marques de

    2017-01-01

    Dissertação de Mestrado apresentada no ISPA - Instituto Universitário para a obtenção de grau de Mestre na especialidade de Psicologia Clínica This study investigated the perceptions on beliefs, stereotypes, roles, preferences and sexual risk-taking with a focus on gender differences from a sample of 1284 young adults. We assessed these perceptions using a sociodemographic questionnaire, a sexual double standard, gender roles and sexual risk-taking scales. We unexpectedly found women to be...

  6. Re-naming D Double Prime

    Science.gov (United States)

    Chao, Benjamin F.

    1999-01-01

    "Knowledge about the dynamics of the D double prime region is a key to unlock some fundamental mysteries of the Earth heat engine which governs a wide range of global geophysical processes from tectonics to geodynamo." This benign sentence makes complete sense to many geophysicists. But for many others, it makes sense all except the odd nomenclature "D double prime". One knows about the crust, upper and lower mantle, outer and inner core, but where is the D double prime region? What meaning does it try to convey? Where is D prime region, or D, or A, B, C regions for that matter, and are there higher-order primes? How does such an odd name come about anyway? D double prime, or more "simply" D", is a generic designation given to the thin shell, about 200 km thick, of the lowermost mantle just above the core-mantle boundary inside the Earth. Incidentally, whether D" is "simpler" than "D double prime" depends on whether you are pronouncing it or writing/typing it; and D" can be confusing to readers in distinguishing quotation marks (such as in the above sentences) and second derivatives, and to word processors in spelling check and indexing.

  7. Doubled strings, negative strings and null waves

    Energy Technology Data Exchange (ETDEWEB)

    Blair, Chris D.A. [Theoretische Natuurkunde, Vrije Universiteit Brussel, and the International Solvay Institutes,Pleinlaan 2, B-1050 Brussels (Belgium)

    2016-11-08

    We revisit the fundamental string (F1) solution in the doubled formalism. We show that the wave-like solution of double field theory (DFT) corresponding to the F1/pp-wave duality pair is more properly a solution of the DFT action coupled to a doubled sigma model action. The doubled string configuration which sources the pp-wave can be thought of as static gauge with the string oriented in a dual direction. We also discuss the DFT solution corresponding to a vibrating string, carrying both winding and momentum. We further show that the solution dual to the F1 in both time and space can be viewed as a “negative string” solution. Negative branes are closely connected to certain exotic string theories which involve unusual signatures for both spacetime and brane worldvolumes. In order to better understand this from the doubled point of view, we construct a variant of DFT suitable for describing theories in which the fundamental string has a Euclidean worldsheet, for which T-dualities appear to change the spacetime signature.

  8. Observing and Measuring Visual Double Stars

    CERN Document Server

    2013-01-01

    In these days of high-precision astrometric satellites, tremendous contributions to the science of astrometry are being made by amateur astronomers around the globe. This second edition of Observing and Measuring Visual Double Stars contains a significant amount of completely new material inspired by the work done by observers - particularly in the USA - since the first edition was published. Fifteen skilled and experienced astronomers have contributed chapters on their own specialization in the various fields. These include how to use the Internet to carry out precise astronomical measurement, an excellent guide to sketching double stars, and information on how to image double stars of unequal brightness. This new edition is the definitive book for those who are serious about this fascinating aspect of astronomy! Author Bob Argyle has been observing visual double stars for more than 40 years, some with the help of the world's biggest refractors, and has been director of the Webb Society Double Star Se...

  9. ITER PF6 double pancakes winding line

    Energy Technology Data Exchange (ETDEWEB)

    Du, Shuangsong [Institute of Plasma Physics, Chinese Academy of Science, Hefei (China); University of Science and Technology of China, Hefei (China); Wen, Wei, E-mail: wenwei@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Science, Hefei (China); Chen, Jin; Wu, Weiyue; Song, Yuntao; Shen, Guang [Institute of Plasma Physics, Chinese Academy of Science, Hefei (China)

    2017-03-15

    Highlights: • ITER PF6 double pancakes “two-in-hand” winding line layout and main parameters were introduced, main winding sequences were also included. • Main features of each winding unit include de-spooling unit, straightening unit, sandblasting and cleaning unit, bending unit, turn insulation wrapping head, rotary table and automatic control system were depicted. • PF6 double pancake winding line was commissioned with PF5 empty jacket conductor after the installation and testing of each unit, ±0.5 mm turn positioning and ±2 turn to turn deviations were achieved. - Abstract: The Poloidal Field (PF) coils are one of the main sub-systems of the ITER magnets. The PF6 coil is being manufactured by the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP) as per the Poloidal Field coils cooperation agreement signed between ASIPP and Fusion for Energy (F4E).The ITER PF6 winding pack is composed by stacking of 9 double pancakes. Each double pancake is wound with a “two-in-hand” configuration. This paper describes the ITER PF6 double pancakes winding line, including layout and main parameters of the winding line, features of main units and the commissioning trial with PF5 empty jacket conductor.

  10. Synthesis of layered double hydroxides from eggshells

    Energy Technology Data Exchange (ETDEWEB)

    Li Songnan [Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, 150001 (China); Wang Fangyong [College of Engineering and Technology, Northeast Forestry University, 150001 (China); Jing Xiaoyan [Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, 150001 (China); Wang Jun, E-mail: zhqw1888@sohu.com [Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, 150001 (China); Saba, Jamil; Liu Qi; Ge Lan; Song Dalei; Zhang Milin [Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, 150001 (China)

    2012-01-16

    Graphical abstract: This is the XRD pattern and TEM image of 4Ca-Al layered double hydroxide, which is obtained from eggshells. It can be seen that the sample is of layered double hydroxide and shows the plate-like agglomerations with an average size of 20-100 nm. Highlights: Black-Right-Pointing-Pointer We synthesize layered double hydroxides from eggshells. Black-Right-Pointing-Pointer Eggshells are the mainly material in this method. Black-Right-Pointing-Pointer The additional alkaline solution is not required. - Abstract: Ca-Al and Ca-Fe layered double hydroxides (LDHs) were successfully synthesized from chicken eggshells by an ultrasonic wave assistant method. The products were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR) techniques. XRD and TEM analyses showed that the 4Ca-Al LDHs were of high purity but other samples were not. The present study provides a simple, efficient and environmental friendly method to obtain LDHs from biowaste eggshells, in which additional alkaline solution is not required for synthesis. Moreover, eggshells provide all the requisite bivalent metal ions, which are needed to form layered double hydroxides.

  11. Double Engine for a Nebula

    Science.gov (United States)

    2009-08-01

    ESO has just released a stunning new image of a field of stars towards the constellation of Carina (the Keel). This striking view is ablaze with a flurry of stars of all colours and brightnesses, some of which are seen against a backdrop of clouds of dust and gas. One unusual star in the middle, HD 87643, has been extensively studied with several ESO telescopes, including the Very Large Telescope Interferometer (VLTI). Surrounded by a complex, extended nebula that is the result of previous violent ejections, the star has been shown to have a companion. Interactions in this double system, surrounded by a dusty disc, may be the engine fuelling the star's remarkable nebula. The new image, showing a very rich field of stars towards the Carina arm of the Milky Way, is centred on the star HD 87643, a member of the exotic class of B[e] stars [1]. It is part of a set of observations that provide astronomers with the best ever picture of a B[e] star. The image was obtained with the Wide Field Imager (WFI) attached to the MPG/ESO 2.2-metre telescope at the 2400-metre-high La Silla Observatory in Chile. The image shows beautifully the extended nebula of gas and dust that reflects the light from the star. The central star's wind appears to have shaped the nebula, leaving bright, ragged tendrils of gas and dust. A careful investigation of these features seems to indicate that there are regular ejections of matter from the star every 15 to 50 years. A team of astronomers, led by Florentin Millour, has studied the star HD 87643 in great detail, using several of ESO's telescopes. Apart from the WFI, the team also used ESO's Very Large Telescope (VLT) at Paranal. At the VLT, the astronomers used the NACO adaptive optics instrument, allowing them to obtain an image of the star free from the blurring effect of the atmosphere. To probe the object further, the team then obtained an image with the Very Large Telescope Interferometer (VLTI). The sheer range of this set of observations

  12. Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 °C or above.

    Science.gov (United States)

    de Ridder, Inger R; de Jong, Frank Jan; den Hertog, Heleen M; Lingsma, Hester F; van Gemert, H Maarten A; Schreuder, A H C M L Tobien; Ruitenberg, Annemieke; Maasland, E Lisette; Saxena, Ritu; Oomes, Peter; van Tuijl, Jordie; Koudstaal, Peter J; Kappelle, L Jaap; Algra, Ale; van der Worp, H Bart; Dippel, Diederik W J

    2015-04-01

    In the first hours after stroke onset, subfebrile temperatures and fever have been associated with poor functional outcome. In the first Paracetamol (Acetaminophen) in Stroke trial, a randomized clinical trial of 1400 patients with acute stroke, patients who were treated with high-dose paracetamol showed more improvement on the modified Rankin Scale at three-months than patients treated with placebo, but this difference was not statistically significant. In the 661 patients with a baseline body temperature of 37.0 °C or above, treatment with paracetamol increased the odds of functional improvement (odds ratio 1.43; 95% confidence interval: 1.02-1.97). This relation was also found in the patients with a body temperature of 36.5 °C or higher (odds ratio 1.31; 95% confidence interval 1.01-1.68). These findings need confirmation. The study aims to assess the effect of high-dose paracetamol in patients with acute stroke and a body temperature of 36.5 °C or above on functional outcome. The Paracetamol (Acetaminophen) In Stroke 2 trial is a multicenter, randomized, double-blind, placebo-controlled clinical trial. We use a power of 85% to detect a significant difference in the scores on the modified Rankin Scale of the paracetamol group compared with the placebo group at a level of significance of 0.05 and assume a treatment effect of 7%. Fifteen-hundred patients with acute ischemic stroke or intracerebral hemorrhage and a body temperature of 36.5 °C or above will be included within 12 h of symptom onset. Patients will be treated with paracetamol in a daily dose of six-grams or matching placebo for three consecutive days. The Paracetamol (Acetaminophen) In Stroke 2 trial has been registered as NTR2365 in The Netherlands Trial Register. The primary outcome will be improvement on the modified Rankin Scale at three-months as analyzed by ordinal logistic regression. If high-dose paracetamol will be proven effective, a simple, safe, and extremely cheap therapy will be

  13. Prevention of mother-to-child transmission of hepatitis B virus: a phase III, placebo-controlled, double-blind, randomized clinical trial to assess the efficacy and safety of a short course of tenofovir disoproxil fumarate in women with hepatitis B virus e-antigen.

    Science.gov (United States)

    Jourdain, Gonzague; Ngo-Giang-Huong, Nicole; Cressey, Tim R; Hua, Lei; Harrison, Linda; Tierney, Camlin; Salvadori, Nicolas; Decker, Luc; Traisathit, Patrinee; Sirirungsi, Wasna; Khamduang, Woottichai; Bowonwatanuwong, Chureeratana; Puthanakit, Thanyawee; Siberry, George K; Watts, Diane Heather; Murphy, Trudy V; Achalapong, Jullapong; Hongsiriwon, Suchat; Klinbuayaem, Virat; Thongsawat, Satawat; Chung, Raymond T; Pol, Stanislas; Chotivanich, Nantasak

    2016-08-09

    Chronic hepatitis B virus (HBV) infection is complicated by cirrhosis and liver cancer. In Thailand, 6-7 % of adults are chronically infected with HBV. The risk of mother-to-child transmission (MTCT) of HBV has been estimated to be about 12 % when mothers have a high hepatitis B viral load, even if infants receive passive-active prophylaxis with HBV immunoglobulin (HBIg) and initiate the hepatitis B vaccine series at birth. We designed a study to assess the efficacy and safety of a short course of maternal tenofovir disoproxil fumarate (TDF) among women with a marker of high viral load for the prevention of MTCT of HBV. The study is a phase III, multicenter (17 sites in Thailand), placebo-controlled, double-blind, randomized 1:1, two-arm clinical trial of TDF 300 mg once daily versus placebo among pregnant women from 28 weeks' gestation through 2-month post-partum. All infants receive HBIg at birth, and a hepatitis B (HB) vaccination series according to Thai guidelines: birth, and age 1, 2, 4 and 6 months. Participant women at study entry must be age ≥18 years, hepatitis B surface antigen (HBsAg) and e-antigen (HBeAg) positive, have alanine aminotransferase (ALT) level 50 mL/min, and no history of anti-HBV antiviral treatment. The target sample size of 328 mother/infant pairs assumed 156 evaluable cases per arm to detect a ≥9 % difference in MTCT transmission (3 % experimental arm versus 12 % placebo arm) with 90 % power. Mothers and infants are followed until 12 months after delivery. The primary infant endpoint is detection of HBsAg, confirmed by detection of HBV DNA at six months of age. Secondary endpoints are maternal and infant adverse events, acute exacerbations of maternal hepatitis B disease (ALT >300 IU/L, defined as a "flare") following discontinuation of study treatment, infant HBV infection status and growth up to 12 months of age. The results of this randomized trial will clarify the efficacy and safety of a short course of

  14. High power double-scale pulses from a gain-guided double-clad fiber laser

    Science.gov (United States)

    Zhang, Haitao; Gao, Gan; Li, Qinghua; Gong, Mali

    2017-03-01

    Generation of high power double-scale pulses from a gain-guided double-clad fiber laser is experimentally demonstrated. By employing the Yb-doped 10/130 double-clad fiber as the gain medium, the laser realizes an output power of 5.1 W and pulse energy of 0.175 µJ at repetition rate of 29.14 MHz. To the best of our knowledge, this average output power is the highest among the reported double-scale pulse oscillators. The autocorrelation trace of pulses contains the short (98 fs) and long (29.5 ps) components, and the spectral bandwidth of the pulse is 27.3 nm. Such double-scale pulses are well suited for seeding the high power MOPA (master oscillator power amplifier) systems, nonlinear frequency conversion and optical coherence tomography.

  15. A magnetic resonance imaging study of double elevator palsy.

    Science.gov (United States)

    Cadera, W; Bloom, J N; Karlik, S; Viirre, E

    1997-06-01

    The pathophysiology of double elevator palsy is poorly understood. We assessed two patients with this condition using magnetic resonance imaging (MRI) to evaluate the appearance of the extraocular muscles. Cross-sectional study. Radiology department of a university-affiliated hospital in London, Ont. Two patients from a private ophthalmology practice who had undergone complete transpositions of the horizontal rectus muscles to treat hypotropia associated with double elevator palsy. MRI. A volume scanning technique was used to obtain maximum information about the muscles. Appearance of the extraocular muscles. In both patients MRI showed decreased volume of the superior rectus muscle on the affected side. The other rectus muscles were normal. This suggested either congenital hypoplasia or paresis of the involved superior rectus muscle. In addition, the full tendon transpositions of the medial and lateral recti did not appreciably change the middle and deep orbital pathways of the transposed horizontal rectus muscles. MRI may be a useful adjunct to saccadic velocity assessments in differentiating between primary inferior rectus restriction, primary superior rectus paresis and congenital supranuclear elevator deficiency.

  16. Double Planet Meets Triple Star

    Science.gov (United States)

    2002-08-01

    High-Resolution VLT Image of Pluto Event on July 20, 2002 A rare celestial phenomenon involving the distant planet Pluto has occurred twice within the past month. Seen from the Earth, this planet moved in front of two different stars on July 20 and August 21, respectively, providing observers at various observatories in South America and in the Pacific area with a long awaited and most welcome opportunity to learn more about the tenuous atmosphere of that cold planet. On the first date, a series of very sharp images of a small sky field with Pluto and the star was obtained with the NAOS-CONICA (NACO) adaptive optics (AO) camera mounted on the ESO VLT 8.2-m YEPUN telescope at the Paranal Observatory. With a diameter of about 2300 km, Pluto is about six times smaller than the Earth. Like our own planet, it possesses a relatively large moon, Charon , measuring 1200 km across and circling Pluto at a distance of about 19,600 km once every 6.4 days. In fact, because of the similarity of the two bodies, the Pluto-Charon system is often referred to as a double planet . At the current distance of nearly 4,500 million km from the Earth, Pluto's disk subtends a very small angle in the sky, 0.107 arcsec. It is therefore very seldom that Pluto - during its orbital motion - passes exactly in front of a comparatively bright star. Such events are known as "occultations" , and it is difficult to predict exactly when and where on the Earth's surface they are visible. Stellar occultations When Pluto moves in front of a star, it casts a "shadow" on the Earth's surface within which an observer cannot see the star, much like the Earth's Moon hides the Sun during a total solar eclipse. During the occultation event, Pluto's "shadow" also moves across the Earth's surface. The width of this shadow is equal to Pluto's diameter, i.e. about 2300 km. One such occultation event was observed in 1988, and two others were expected to occur in 2002, according to predictions published in 2000 by

  17. Double-layer ice from first principles

    Science.gov (United States)

    Chen, Ji; Schusteritsch, Georg; Pickard, Chris J.; Salzmann, Christoph G.; Michaelides, Angelos

    2017-03-01

    The formation of monolayer and multilayer ice with a square lattice structure has recently been reported on the basis of transmission electron microscopy experiments, renewing interest in confined two-dimensional ice. Here we report a systematic density functional theory study of double-layer ice in nanoconfinement. A phase diagram as a function of confinement width and lateral pressure is presented. Included in the phase diagram are honeycomb hexagonal, square-tube, hexagonal-close-packed, and buckled-rhombic structures. However, contrary to experimental observations, square structures do not feature: our most stable double-layer square structure is predicted to be metastable. This study provides general insight into the phase transitions of double-layer confined ice and a fresh theoretical perspective on the stability of square ice in graphene nanocapillary experiments.

  18. Neutrinoless double beta decay from lattice QCD

    Science.gov (United States)

    Nicholson, Amy; Cheng, Chia; Berkowitz, Evan; Rinaldi, Enrico; Walker-Loud, Andre; Vranas, Pavlos; Kurth, Thorsten; Clark, M. A.; Garron, Nicolas; Tiburzi, Brian; Monge-Camacho, Henry; Brantley, David; Joo, Balint; Callat Collaboration

    2017-09-01

    Lepton number-violating neutrinoless double beta decay is a natural consequence of Majorana neutrinos and many BSM theories, and, if observed, could potentially explain the observed matter/anti-matter asymmetry in the universe. Several experimental searches for these processes using nuclear sources are planned and/or underway worldwide, and understanding quantitatively how neutrinoless double beta decay would manifest in nuclear environments is key for interpreting any observed signals. While long-range, light neutrino exchange is the most common mechanism studied, short-range interactions involving heavy mediator exchange may also contribute. In this talk I will give an overview of the microscopic observables relevant for experimental searches for neutrinoless double beta decay which may be calculated directly from QCD using lattice methods, and present results for short-range matrix elements contributing to pion exchange diagrams between nucleons.

  19. Excitonic superfluid phase in double bilayer graphene

    Science.gov (United States)

    Li, J. I. A.; Taniguchi, T.; Watanabe, K.; Hone, J.; Dean, C. R.

    2017-08-01

    A spatially indirect exciton is created when an electron and a hole, confined to separate layers of a double quantum well system, bind to form a composite boson. Such excitons are long-lived, and in the limit of strong interactions are predicted to undergo a Bose-Einstein condensate-like phase transition into a superfluid ground state. Here, we report evidence of an exciton condensate in the quantum Hall effect regime of double-layer structures of bilayer graphene. Interlayer correlation is identified by quantized Hall drag at matched layer densities, and the dissipationless nature of the phase is confirmed in the counterflow geometry. A selection rule for the condensate phase is observed involving both the orbital and valley indices of bilayer graphene. Our results establish double bilayer graphene as an ideal system for studying the rich phase diagram of strongly interacting bosonic particles in the solid state.

  20. Generalised kinematics for double field theory

    Science.gov (United States)

    Freidel, Laurent; Rudolph, Felix J.; Svoboda, David

    2017-11-01

    We formulate a kinematical extension of Double Field Theory on a 2 d-dimensional para-Hermitian manifold (P,η, ω ) where the O( d, d) metric η is supplemented by an almost symplectic two-form ω. Together η and ω define an almost bi-Lagrangian structure K which provides a splitting of the tangent bundle TP=L\\oplus \\tilde{L} into two Lagrangian sub-spaces. In this paper a canonical connection and a corresponding generalised Lie derivative for the Leibniz algebroid on TP are constructed. We find integrability conditions under which the symmetry algebra closes for general η and ω, even if they are not flat and constant. This formalism thus provides a generalisation of the kinematical structure of Double Field Theory. We also show that this formalism allows one to reconcile and unify Double Field Theory with Generalised Geometry which is thoroughly discussed.

  1. Double Dirac Semimetals in Three Dimensions.

    Science.gov (United States)

    Wieder, Benjamin J; Kim, Youngkuk; Rappe, A M; Kane, C L

    2016-05-06

    We study a class of Dirac semimetals that feature an eightfold-degenerate double Dirac point. We show that 7 of the 230 space groups can host such Dirac points and argue that they all generically display linear dispersion. We introduce an explicit tight-binding model for space groups 130 and 135. Space group 135 can host an intrinsic double Dirac semimetal with no additional states at the Fermi energy. This defines a symmetry-protected topological critical point, and we show that a uniaxial compressive strain applied in different directions leads to topologically distinct insulating phases. In addition, the double Dirac semimetal can accommodate topological line defects that bind helical modes. Connections are made to theories of strongly interacting filling-enforced semimetals, and potential materials realizations are discussed.

  2. Limiting effects in double EEX beamline

    Science.gov (United States)

    Ha, G.; Power, J. G.; Conde, M.; Doran, D. S.; Gai, W.

    2017-07-01

    The double emittance exchange (EEX) beamline is suggested to overcome the large horizontal emittance and transverse jitter issues associated with the single EEX beamline while preserving its powerful phase-space manipulation capability. However, the double EEX beamline also has potential limitations due to coherent synchrotron radiation (CSR) and transverse jitter. The former limitation arises because double EEX uses twice as many bending magnets as single EEX which means stronger CSR effects degrading the beam quality. The latter limitation arises because a longitudinal jitter in front of the first EEX beamline is converted into a transverse jitter in the middle section (between the EEX beamlines) which can cause beam loss or beam degradation. In this paper, we numerically explore the effects of these two limitations on the emittance and beam transport.

  3. Innocuous Double Rounding of Basic Arithmetic Operations

    Directory of Open Access Journals (Sweden)

    Pierre Roux

    2014-11-01

    Full Text Available Double rounding occurs when a floating-point value is first rounded to an intermediate precision before being rounded to a final precision. The result of two such consecutive roundings can differ from the result obtained when directly rounding to the final precision. Double rounding practically happens, for instance, when implementing the IEEE754 binary32 format with an arithmetic unit performing operations only in the larger binary64 format, such as done in the PowerPC or x87 floating-point units. It belongs to the folklore in the floating-point arithmetic community that double rounding is innocuous for the basic arithmetic operations (addition, division, multiplication, and square root as soon as the final precision is about twice larger than the intermediate one. This paper adresses the formal proof of this fact considering underflow cases and its extension to radices other than two.

  4. Is Double-Blinded Peer Review Necessary? The Effect of Blinding on Review Quality.

    Science.gov (United States)

    Chung, Kevin C; Shauver, Melissa J; Malay, Sunitha; Zhong, Lin; Weinstein, Aaron; Rohrich, Rod J

    2015-12-01

    The review process can be completely open, double-blinded, or somewhere in between. Double-blinded peer review, where neither the authors' nor peer reviewers' identities are shared with each other, is thought to be the fairest system, but there is evidence that it does not affect reviewer behavior or influence decisions. Furthermore, even without presenting author names, authorship is often apparent to reviewers, especially in small specialties. In conjunction with Plastic and Reconstructive Surgery (PRS), the authors examined the effect of double-blinded review on review quality, reviewer publishing recommendation, and reviewer manuscript rating. The authors hypothesized that double-blinded review will not improve review quality and will not affect recommendation or rating. Traditionally, PRS peer review has been conducted in a single-blinded fashion. During a 3-month period of standard operation of the Journal, the authors examined reviews, recommendations, and manuscript ratings. Beginning October 1, 2014, PRS started conducting reviews in a double-blinded manner. The authors examined the additional reviews submitted during a 3-month period after the change. Review quality was assessed using the validated Review Quality Instrument. Double-blinding had no effect on reviewer publishing recommendation or manuscript ranking. Review quality did not improve after the implementation of double-blinded review. Blinding was successful 66 percent of the time. The most common reasons for blinding failure were reviewer familiarity with authors' work and author self-citation. Double-blinding adds considerable work for authors and editorial staff and has no positive effect on review quality. Furthermore, the authors' results revealed no publication bias based on author identity at PRS.

  5. Double promoter expression systems for recombinant protein production by industrial microorganisms.

    Science.gov (United States)

    Öztürk, Sibel; Ergün, Burcu Gündüz; Çalık, Pınar

    2017-10-01

    Using double promoter expression systems is a promising approach to increase heterologous protein production. In this review, current double promoter expression systems for the production of recombinant proteins (r-proteins) by industrially important bacteria, Bacillus subtilis and Escherichia coli; and yeasts, Saccharomyces cerevisiae and Pichia pastoris, are discussed by assessing their potentials and drawbacks. Double promoter expression systems need to be designed to maintain a higher specific product formation rate within the production domain. While bacterial double promoter systems have been constructed as chimeric tandem promoters, yeast dual promoter systems have been developed as separate expression cassettes. To increase production and productivity, the optimal transcriptional activity should be justified either by simultaneously satisfying the requirements of both promoters, or by consecutively stimulating the changeover from one to another in a biphasic process or via successive-iterations. Thus, considering the dynamics of a fermentation process, double promoters can be classified according to their operational mechanisms, as: i) consecutively operating double promoter systems, and ii) simultaneously operating double promoter systems. Among these metabolic design strategies, extending the expression period with two promoters activated under different conditions, or enhancing the transcriptional activity with two promoters activated under similar conditions within the production domain, can be applied independently from the host. Novel studies with new insights, which aim a rational systematic design and construction of dual promoter expression vectors with tailored transcriptional activity, will empower r-protein production with enhanced production and productivity. Finally, the current state-of-the-art review emphasizes the advantages of double promoter systems along with the necessity for discovering new promoters for the development of more

  6. Double-digit coding of examination math problems

    Directory of Open Access Journals (Sweden)

    Agnieszka Sułowska

    2013-09-01

    Full Text Available Various methods are used worldwide to evaluate student solutions to examination tasks. Usually the results simply provide information about student competency and after aggregation, are also used as a tool of making comparisons between schools. In particular, the standard evaluation methods do not allow conclusions to be drawn about possible improvements of teaching methods. There are however, task assessment methods which not only allow description of student achievement, but also possible causes of failure. One such method, which can be applied to extended response tasks, is double-digit coding which has been used in some international educational research. This paper presents the first Polish experiences of applying this method to examination tasks in mathematics, using a special coding key to carry out the evaluation. Lessons learned during the coding key construction and its application in the assessment process are described.

  7. Course of Magnetic Resonance Imaging-Detected Inflammation and Structural Lesions in the Sacroiliac Joints of Patients in the Randomized, Double-Blind, Placebo-Controlled Danish Multicenter Study of Adalimumab in Spondyloarthritis, as Assessed by the Berlin and Spondyloarthritis Research Consortium of Canada Methods

    DEFF Research Database (Denmark)

    Pedersen, Susanne J; Poddubnyy, Denis; Sørensen, Inge J

    2016-01-01

    OBJECTIVES: To investigate changes in MRI inflammation and structural lesions in the sacroiliac joints (SIJ) during treatment with adalimumab (ADA) vs. placebo (PLA). METHODS: In a 48-week double-blind placebo-controlled trial, 52 SpA patients were randomized to sc. ADA 40 mg (n=25) or PLA for 12...

  8. Jonckheere Double Star Photometry - Part IV: Cetus

    Science.gov (United States)

    Knapp, Wilfried

    2017-04-01

    If any double star discoverer is in urgent need of photometry then it is Jonckheere. There are over 3000 Jonckheere objects listed in the WDS catalog and a good part of them have magnitudes which are obviously far too bright. This report covers the Jonckheere objects in the constellation Cet. Only one image per object was taken as despite the risk of random effects even a single measurement is better than the currently usually given estimation although the J-objects in this southern constellation are better covered with observations as usual for Jonckheere doubles.

  9. Double-partition Quantum Cluster Algebras

    DEFF Research Database (Denmark)

    Jakobsen, Hans Plesner; Zhang, Hechun

    2012-01-01

    A family of quantum cluster algebras is introduced and studied. In general, these algebras are new, but sub-classes have been studied previously by other authors. The algebras are indexed by double parti- tions or double flag varieties. Equivalently, they are indexed by broken lines L. By grouping...... together neighboring mutations into quantum line mutations we can mutate from the cluster algebra of one broken line to another. Compatible pairs can be written down. The algebras are equal to their upper cluster algebras. The variables of the quantum seeds are given by elements of the dual canonical basis....

  10. Unique double recurrence of cerebral arteriovenous malformation.

    Science.gov (United States)

    Nagm, Alhusain; Horiuchi, Tetsuyoshi; Ichinose, Shunsuke; Hongo, Kazuhiro

    2015-09-01

    Surgically treated patients with arteriovenous malformations (AVMs) are considered cured when the postoperative angiogram proves complete resection. However, despite no residual nidus or early draining vein on postoperative angiogram, rare instances of AVM recurrence have been reported in adults. In this paper, the authors present a case of a 24-year-old woman with asymptomatic double recurrence of her cerebral AVM after angiographically proven complete resection. To the authors' knowledge, this patient represents the first case with double de novo asymptomatic recurrence of Spetzler-Martin grade I AVM. Also, she represents the first case with unique AVM criteria in each recurrence.

  11. Simulation Results of Double Forward Converter

    Directory of Open Access Journals (Sweden)

    P. Vijaya KUMAR

    2009-12-01

    Full Text Available This work aims to find a better forward converter for DC to DC conversion.Simulation of double forward converter in SMPS system is discussed in this paper. Aforward converter with RCD snubber to synchronous rectifier and/or to current doubleris also discussed. The evolution of the forward converter is first reviewed in a tutorialfashion. Performance parameters are discussed including operating principle, voltageconversion ratio, efficiency, device stress, small-signal dynamics, noise and EMI. Itscircuit operation and its performance characteristics of the forward converter with RCDsnubber and double forward converter are described and the simulation results arepresented.

  12. Double conformal space-time algebra

    Science.gov (United States)

    Easter, Robert Benjamin; Hitzer, Eckhard

    2017-01-01

    The Double Conformal Space-Time Algebra (DCSTA) is a high-dimensional 12D Geometric Algebra G 4,8that extends the concepts introduced with the Double Conformal / Darboux Cyclide Geometric Algebra (DCGA) G 8,2 with entities for Darboux cyclides (incl. parabolic and Dupin cyclides, general quadrics, and ring torus) in spacetime with a new boost operator. The base algebra in which spacetime geometry is modeled is the Space-Time Algebra (STA) G 1,3. Two Conformal Space-Time subalgebras (CSTA) G 2,4 provide spacetime entities for points, flats (incl. worldlines), and hyperbolics, and a complete set of versors for their spacetime transformations that includes rotation, translation, isotropic dilation, hyperbolic rotation (boost), planar reflection, and (pseudo)spherical inversion in rounds or hyperbolics. The DCSTA G 4,8 is a doubling product of two G 2,4 CSTA subalgebras that inherits doubled CSTA entities and versors from CSTA and adds new bivector entities for (pseudo)quadrics and Darboux (pseudo)cyclides in spacetime that are also transformed by the doubled versors. The "pseudo" surface entities are spacetime hyperbolics or other surface entities using the time axis as a pseudospatial dimension. The (pseudo)cyclides are the inversions of (pseudo)quadrics in rounds or hyperbolics. An operation for the directed non-uniform scaling (anisotropic dilation) of the bivector general quadric entities is defined using the boost operator and a spatial projection. DCSTA allows general quadric surfaces to be transformed in spacetime by the same complete set of doubled CSTA versor (i.e., DCSTA versor) operations that are also valid on the doubled CSTA point entity (i.e., DCSTA point) and the other doubled CSTA entities. The new DCSTA bivector entities are formed by extracting values from the DCSTA point entity using specifically defined inner product extraction operators. Quadric surface entities can be boosted into moving surfaces with constant velocities that display the length

  13. Double Harmonic Transmission (D.H.T.

    Directory of Open Access Journals (Sweden)

    Sava Ianici

    2006-10-01

    Full Text Available The paper presents the construction and functioning of a new type of harmonic drive named double harmonic transmission (D.H.T.. In the second part of this paper is presented the dynamic analysis of the double harmonic transmission, which is based on the results of the experimental researches on the D.H.T. This study of the stress status and the forces distribution is necessary for to determine the durability on the portant elements of the D.H.T.

  14. Jonckheere Double Star Photometry - Part VI: Auriga

    Science.gov (United States)

    Knapp, Wilfried

    2017-07-01

    If any double star discoverer is in urgent need of photometry then it is Jonckheere. There are over 3000 Jonckheere objects listed in the WDS catalog and a good part of them has magnitudes which are obviously far too bright. This report covers the Jonckheere objects in the constellation Auriga. Only one image per object was taken as despite the risk of random effects even a single instance visual magnitude measurement is better than the currently usually given estimation although the J-objects in this constellation seem with some exceptions better covered with observations as usual for Jonckheere doubles.

  15. Jonckheere Double Star Photometry - Part V: Cancer

    Science.gov (United States)

    Knapp, Wilfried

    2017-07-01

    If any double star discoverer is in urgent need of photometry then it is Jonckheere. There are over 3000 Jonckheere objects listed in the WDS catalog and a good part of them have magnitudes which are obviously far too bright. This report covers the Jonckheere objects in the constellation Cancer. Only one image per object was taken as despite the risk of random effects even a single measurement is better than the currently usually given estimation, although the J-objects in this constellation seem with some exceptions better covered with observations as usual for Jonckheere doubles.

  16. Probabilistic double guarantee kidnapping detection in SLAM.

    Science.gov (United States)

    Tian, Yang; Ma, Shugen

    2016-01-01

    For determining whether kidnapping has happened and which type of kidnapping it is while a robot performs autonomous tasks in an unknown environment, a double guarantee kidnapping detection (DGKD) method has been proposed. The good performance of DGKD in a relative small environment is shown. However, a limitation of DGKD is found in a large-scale environment by our recent work. In order to increase the adaptability of DGKD in a large-scale environment, an improved method called probabilistic double guarantee kidnapping detection is proposed in this paper to combine probability of features' positions and the robot's posture. Simulation results demonstrate the validity and accuracy of the proposed method.

  17. Dynamically possible pattern speeds of double bars

    OpenAIRE

    Maciejewski, Witold

    2009-01-01

    The method to study oscillating potentials of double bars, based on invariant loops, is introduced here in a new way, intended to be more intelligible. Using this method, I show how the orbital structure of a double-barred galaxy (nested bars) changes with the variation of nuclear bar's pattern speed. Not all pattern speeds are allowed when the inner bar rotates in the same direction as the outer bar. Below certain minimum pattern speed orbital support for the inner bar abruptly disappears, w...

  18. Facility Location with Double-peaked Preferences

    DEFF Research Database (Denmark)

    Filos-Ratsikas, Aris; Li, Minming; Zhang, Jie

    2015-01-01

    We study the problem of locating a single facility on a real line based on the reports of self-interested agents, when agents have double-peaked preferences, with the peaks being on opposite sides of their locations. We observe that double-peaked preferences capture real-life scenarios and thus...... complement the well-studied notion of single-peaked preferences. We mainly focus on the case where peaks are equidistant from the agents’ locations and discuss how our results extend to more general settings. We show that most of the results for single-peaked preferences do not directly apply to this setting...

  19. Double sequential defibrillation for refractory ventricular fibrillation.

    Science.gov (United States)

    El Tawil, Chady; Mrad, Sandra; Khishfe, Basem F

    2017-12-01

    A 54-year-old suffered from an out-of-hospital cardiac arrest. Compressions were started within minutes and the patient was in refractory ventricular fibrillation despite multiple asynchronized shocks and maximal doses of antiarrhythmic agents. Double sequential defibrillation was attempted with successful Return Of Spontaneous Circulation (ROSC) after a total of 61min of cardiac arrest. The patient was discharged home neurologically intact. Double sequential defibrillation could be a simple effective approach to patients with refractory ventricular fibrillation. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. HANFORD DOUBLE SHELL TANK (DST) THERMAL & SEISMIC PROJECT SEISMIC ANALYSIS OF HANFORD DOUBLE SHELL TANKS

    Energy Technology Data Exchange (ETDEWEB)

    MACKEY, T.C.

    2006-03-17

    M&D Professional Services, Inc. (M&D) is under subcontract to Pacific Northwest National Laboratory (PNNL) to perform seismic analysis of the Hanford Site double-shell tanks (DSTs) in support of a project entitled ''Double-Shell Tank (DSV Integrity Project--DST Thermal and Seismic Analyses)''. The overall scope of the project is to complete an up-to-date comprehensive analysis of record of the DST system at Hanford in support of Tri-Party Agreement Milestone M-48-14, The work described herein was performed in support of the seismic analysis of the DSTs. The thermal and operating loads analysis of the DSTs is documented in Rinker et al. (2004). The work statement provided to M&D (PNNL 2003) required that the seismic analysis of the DSTs assess the impacts of potentially non-conservative assumptions in previous analyses and account for the additional soil mass due to the as-found soil density increase, the effects of material degradation, additional thermal profiles applied to the full structure including the soil-structure response with the footings, the non-rigid (low frequency) response of the tank roof, the asymmetric seismic-induced soil loading, the structural discontinuity between the concrete tank wall and the support footing and the sloshing of the tank waste. The seismic analysis considers the interaction of the tank with the surrounding soil and the effects of the primary tank contents. The DSTs and the surrounding soil are modeled as a system of finite elements. The depth and width of the soil incorporated into the analysis model are sufficient to obtain appropriately accurate analytical results. The analyses required to support the work statement differ from previous analysis of the DSTs in that the soil-structure interaction (SSI) model includes several (nonlinear) contact surfaces in the tank structure, and the contained waste must be modeled explicitly in order to capture the fluid-structure interaction behavior between the primary

  1. Metabolic and mechanical involvement of arms and legs in simulated double pole skiing

    DEFF Research Database (Denmark)

    Rud, B; Secher, N H; Nilsson, J

    2014-01-01

    We evaluated arm and leg work rate and metabolism during double pole ergometer skiing. Thermodilution arm and leg blood flow was determined together with the arterial to venous difference for oxygen, while the work rate was assessed in eight male recreational skiers [24 (SD 7) years]. When work...

  2. Family Adaptation to Stroke: A Metasynthesis of Qualitative Research based on Double ABCX Model

    Directory of Open Access Journals (Sweden)

    Ali Hesamzadeh, RN, PhD Student of Nursing

    2015-09-01

    Conclusions: The results of the study are in conformity with the tenets of the Double ABCX Model. Family adaptation is a dynamic process and the present study findings provide rich information on proper assessment and intervention to the practitioners working with families of stroke survivors.

  3. Examining the Double-Deficit Hypothesis in an Orthographically Consistent Language

    Science.gov (United States)

    Torppa, Minna; Georgiou, George; Salmi, Paula; Eklund, Kenneth; Lyytinen, Heikki

    2012-01-01

    We examined the double-deficit hypothesis in Finnish. One hundred five Finnish children with high familial risk for dyslexia and 90 children with low family risk were followed from the age of 3 1/2 years until Grade 3. Children's phonological awareness, rapid naming speed, text reading, and spelling were assessed. A deficit in rapid automatized…

  4. Double-leg stance and dynamic balance in individuals with functional ankle instability.

    NARCIS (Netherlands)

    Groters, S.; Groen, B.E.; Cingel, R. van; Duysens, J.E.J.

    2013-01-01

    To investigate whether double-leg stance could reveal balance deficits in subjects with functional ankle instability (FAI) and whether such an assessment of static balance would be correlated with measures of dynamic instability, 16 individuals with FAI and 16 healthy controls participated in this

  5. Double parton scattering in the ultraviolet. Addressing the double counting problem

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Gaunt, Jonathan R. [Nikhef Theory Group, Amsterdam (Netherlands); Amsterdam VU Univ. (Netherlands)

    2016-11-15

    An important question in the theory of double parton scattering is how to incorporate the possibility of the parton pairs being generated perturbatively via 1→ 2splitting into the theory, whilst avoiding double counting with single parton scattering loop corrections. Here, we describe a consistent approach for solving this problem, which retains the notion of double parton distributions (DPDs) for individual hadrons. Further, we discuss the construction of appropriate model DPDs in our framework, and the use of these to compute the DPS part, presenting DPS 'luminosities' from our model DPDs for a few sample cases.

  6. Material capture by double lunar gravity assist

    Science.gov (United States)

    Ross, D. J.

    1980-01-01

    The equations yielding the performance of a single lunar flyby in removing incoming hyperbolic excess velocity to capture payloads on interplanetary trajectories are briefly derived. The impossibility of using a single lunar flyby to capture a body entering the earth-moon system with a hyperbolic velocity in excess of about 1.9 km/s is discussed, and a method of using a double flyby of the moon to significantly improve this performance is developed. The equations for achieving a double lunar flyby are derived by solving the orbital equations and Lambert's problem both for the incoming trajectory in the plane of the moon's orbit and for arbitrary declination. For the in-plane case it is shown that the maximum removable hyperbolic excess velocity is 2.2687 km/s. For the inclined case, it is shown that the use of a double lunar flyby allows capture for declinations in excess of 54 degrees, and that for declinations less than 38 degrees the double lunar flyby offers better performance than the single lunar flyby.

  7. On double Hurwitz numbers with completed cycles

    NARCIS (Netherlands)

    Shadrin, S.; Spitz, L.; Zvonkine, D.

    2012-01-01

    In this paper, we collect a number of facts about double Hurwitz numbers, where the simple branch points are replaced by their more general analogues: completed (r + 1)-cycles. In particular, we give a geometric interpretation of these generalized Hurwitz numbers and derive a cut-and-join operator

  8. The Modular Construction of DNA Double Helix

    Indian Academy of Sciences (India)

    host; its usual right-handed helix profile can change all the way to the left-handed double one, the entire spectrum with expen- diture of minimum energy. Its major groove can play host to countless guests leading to recognition and the resulting bio- logical functions; its minor groove can receive antibiotics initi-.

  9. Double Pomeron Exchange: the early years

    Energy Technology Data Exchange (ETDEWEB)

    Albrow, Michael G. [Fermilab

    2014-09-01

    I review the early experimental searches for double pomeron exchange, the first observations at the CERN Intersecting Storage Rings (ISR) and further studies at the SPS and Tevatron (fixed target). I only have space for a superficial coverage of some highlights, and will not cover later colliders with √s > GeV.

  10. Oxygen isotope fractionation in double carbonates.

    Science.gov (United States)

    Zheng, Yong-Fei; Böttcher, Michael E

    2016-01-01

    Oxygen isotope fractionations in double carbonates of different crystal structures were calculated by the increment method. Synthesis experiments were performed at 60 °C and 100 °C to determine oxygen and carbon isotope fractionations involving PbMg[CO3]2. The calculations suggest that the double carbonates of calcite structure are systematically enriched in (18)O relative to those of aragonite and mixture structures. Internally consistent oxygen isotope fractionation factors are obtained for these minerals with respect to quartz, calcite and water at a temperature range of 0-1200 °C. The calculated fractionation factors for double carbonate-water systems are generally consistent with the data available from laboratory experiments. The experimentally determined fractionation factors for PbMg[CO3]2, BaMg[CO3]2 and CaMg[CO3]2 against H2O not only fall between fractionation factors involving pure carbonate end-members but are also close to the calculated fractionation factors. In contrast, experimentally determined carbon isotope fractionation factors between PbMg[CO3]2 and CO2 are much closer to theoretical predictions for the cerussite-CO2 system than for the magnesite-CO2 system, similar to the fractionation behavior for BaMg[CO3]2. Therefore, the combined theoretical and experimental results provide insights into the effects of crystal structure and exchange kinetics on oxygen isotope partitioning in double carbonates.

  11. Double-Stranded Peptide Nucleic Acids

    DEFF Research Database (Denmark)

    2001-01-01

    A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker....

  12. Double tracks test site characterization report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This report presents the results of site characterization activities performed at the Double Tracks Test Site, located on Range 71 North, of the Nellis Air Force Range (NAFR) in southern Nevada. Site characterization activities included reviewing historical data from the Double Tracks experiment, previous site investigation efforts, and recent site characterization data. The most recent site characterization activities were conducted in support of an interim corrective action to remediate the Double Tracks Test Site to an acceptable risk to human health and the environment. Site characterization was performed using a phased approach. First, previously collected data and historical records sere compiled and reviewed. Generalized scopes of work were then prepared to fill known data gaps. Field activities were conducted and the collected data were then reviewed to determine whether data gaps were filled and whether other areas needed to be investigated. Additional field efforts were then conducted, as required, to adequately characterize the site. Characterization of the Double Tracks Test Site was conducted in accordance with the US Department of Energy`s (DOE) Streamlined Approach for Environmental Restoration (SAFER).

  13. Constraining double-parton correlations and interferences

    NARCIS (Netherlands)

    Kasemets, T.; Mulders, P.J.G.

    2015-01-01

    Double-parton scattering (DPS) has become very relevant as a background to interesting analyses performed by the experiments at the LHC. It encodes knowledge of correlations between the proton constituents not accessible in single-parton scattering. Within perturbative QCD DPS is described in terms

  14. New orbital elements for 5 double stars

    Directory of Open Access Journals (Sweden)

    Olević D.

    2001-01-01

    Full Text Available In this paper are presented recalculated elliptical and Thiel-Innes orbitatal elements for the following double stars: WDS05255-0033, WDS12272+2701, WDS 13336+2944 and WDS 21031+0132 (two versions. The elements of the pair WDS 06074+2640 = McA 25 are calculated for the first time.

  15. Double-compression method for biomedical images

    Science.gov (United States)

    Antonenko, Yevhenii A.; Mustetsov, Timofey N.; Hamdi, Rami R.; Małecka-Massalska, Teresa; Orshubekov, Nurbek; DzierŻak, RóŻa; Uvaysova, Svetlana

    2017-08-01

    This paper describes a double compression method (DCM) of biomedical images. A comparison of image compression factors in size JPEG, PNG and developed DCM was carried out. The main purpose of the DCM - compression of medical images while maintaining the key points that carry diagnostic information. To estimate the minimum compression factor an analysis of the coding of random noise image is presented.

  16. Single and Double Superconducting Coplanar Waveguide Resonators

    Science.gov (United States)

    Zhao, Na; Liu, Jian-She; Li, Hao; Li, Tie-Fu; Chen, Wei

    2012-08-01

    Transmission characteristics of single and double coplanar waveguide (CPW) resonators are simulated. The crosstalk of two CPW resonators located on the same chip is observed in simulation as well as in low temperature measurement results. The crosstalk behaves as exponential attenuation versus the distance between two resonators.

  17. [Euthanasia and the doctrine of double effect].

    Science.gov (United States)

    Klein, Martin

    2005-01-01

    Direct active euthanasia is prohibited in most countries while passive and indirect is not. However, many arguments against the legalization of voluntary active euthanasia are flawed. Ethical differences between active and passive or indirect euthanasia are difficult to maintain especially when the passivity of the actor causes death. The crucial point is not activity or passivity but respect for the autonomy of individual human beings. In particular there appears to be little ethical difference between active and indirect euthanasia. Indirect euthanasia has often been justified by the principle of double effect, which traces back to Thomas Aquinas. But resorting to this rule contains a logical fallacy. The principle of double effect does not allow foreseen and unwanted adverse effects of an action to occur when they are avoidable. In terminal sedation, an example for indirect euthanasia, hypoxemia and dehydration can easily be prevented by respirator therapy and fluid administration. Therefore the rule of double effect is not applicable. Indirect and direct active euthanasia cannot be ethically distinguished by resorting to the principle of double effect.

  18. The Double Bind: The next Generation

    Science.gov (United States)

    Malcom, Lindsey E.; Malcom, Shirley M.

    2011-01-01

    In this foreword, Shirley Malcom and Lindsey Malcom speak to the history and current status of women of color in science, technology, engineering, and mathematics (STEM) fields. As the author of the seminal report "The Double Bind: The Price of Being a Minority Woman in Science", Shirley Malcom is uniquely poised to give us an insightful…

  19. [Double aortic arch: prenatal case report].

    Science.gov (United States)

    Budziszewska, Patrycja; Kuka, Dorota; Sodowski, Marcin; Sodowski, Krzysztof; Jeanty, Philippe; Skrzypulec, Violetta

    2009-09-01

    We have presented a case of prenatal double aortic arch, diagnosed by ultrasound, to demonstrate the importance of 3-vessel view by detecting aortic arch abnormalities. Double aortic arch is one the most common types of the vascular ring. The suspicion of a double aortic arch is raised by detecting the U-sign which is formed by the combination of both aortic arches and the left ductus arteriosus. In the 3-vessel view the ascending aorta and aortic arch are pointing to the right, whereas the left arch points to the left, and the trachea is seen between. The 4-chamber view appears normal, but the descending aorta is deviated medially. Literature review revealed an association between double aortic arch and congenital heart diseases in approximately 20% of cases; most often tetralogy of Fallot, transposition of great vessels, ventricular septal defects. Rarely there can be atresia of the segment of the aortic arch, which can be difficult to differentiate from other aortic arch anomalies associated with chromosomal abnormalities such as microdeletion of chromosome 22q11.

  20. An Optimal Double Inequality for Means

    Directory of Open Access Journals (Sweden)

    Qian Wei-Mao

    2010-01-01

    Full Text Available For , the generalized logarithmic mean , arithmetic mean and geometric mean of two positive numbers and are defined by , ; , , , ; , , ; , , ; and , respectively. In this paper, we give an answer to the open problem: for , what are the greatest value and the least value , such that the double inequality holds for all ?

  1. Double orifice mitral valve; a coincidental finding

    NARCIS (Netherlands)

    Westendorp, Iris C. D.; de Bruin-Bon, H. A. C. M.; Hrudova, Jana

    2006-01-01

    A double orifice mitral valve (DOMV) represents a rare congenital malformation characterised by two valve orifices with two separate subvalvular apparatus. This case demonstrates the necessity of careful imaging of the mitral valve apparatus, not only in patients with atrioventricular septal

  2. Statistical Convergence of Double Sequences of Order

    Directory of Open Access Journals (Sweden)

    R. Çolak

    2013-01-01

    Full Text Available We intend to make a new approach and introduce the concepts of statistical convergence of order and strongly -Cesàro summability of order for double sequences of complex or real numbers. Also, some relations between the statistical convergence of order and strong -Cesàro summability of order are given.

  3. The College Double Major and Subsequent Earnings

    Science.gov (United States)

    Hemelt, Steven W.

    2010-01-01

    In this study I examine the relationship between graduating from college with two majors rather than one and labor market earnings using the 2003 National Survey of College Graduates. Because institutions are heterogeneous both in terms of overall quality and in the availability of opportunities to double major, I attempt to control for such…

  4. Salinity transfer in bounded double diffusive convection

    NARCIS (Netherlands)

    Yang, Yantao; van der Poel, Erwin; Ostilla Monico, Rodolfo; Sun, Chao; Verzicco, Roberto; Grossmann, Siegfried; Lohse, Detlef

    2015-01-01

    The double diffusive convection between two parallel plates is numerically studied for a series of parameters. The flow is driven by the salinity difference and stabilised by the thermal field. Our simulations are directly compared with experiments by Hage & Tilgner (Phys. Fluids, vol. 22, 2010,

  5. State dynamics of a double sandbar system

    NARCIS (Netherlands)

    Price, T.D.; Ruessink, B.G.

    2011-01-01

    A 9.3-year dataset of low-tide time-exposure images from Surfers Paradise, Northern Gold Coast, Australia was used to characterise the state dynamics of a double sandbar system. The morphology of the nearshore sandbars was described by means of the sequential bar state classification scheme of

  6. The invertible double of elliptic operators

    DEFF Research Database (Denmark)

    Booss-Bavnbek, Bernhelm; Lesch, Matthias; Zhu, Chaofeng

    We construct a canonical invertible double for general first order elliptic differential operators over smooth compact manifolds with boundary and derive a natural formula for the Calderon projector which yields a generalization of the famous Cobordism Theorem. Assuming symmetric principal symbol...

  7. Double-balloon endoscopy: Who needs it?

    DEFF Research Database (Denmark)

    Hendel, J.W.; Vilmann, P.; Jensen, T.

    2008-01-01

    Objective. Double-balloon endoscopy (DBE) made the small bowel accessible to inspection and therapy in its entirety. However, DBE is a time-consuming procedure that requires a highly skilled endoscopist, several nurses and - more often than not - anesthesiological support. This makes the selection...

  8. Under the Gaze of Double Critique

    DEFF Research Database (Denmark)

    Sabih, Joshua

    2015-01-01

    of the theory of double critique: decolonisation, desacralisation and the orphan book are operative in Ḫaṭībī´s analysis of Orientalism, identity, and the issue of origin. As a professional outsider, Ḫaṭībī follows conceptually and methodologically the rules of the epistemological critique in an enunciation...

  9. A Morphism Double Category and Monoidal Structure

    Directory of Open Access Journals (Sweden)

    Saikat Chatterjee

    2013-01-01

    Full Text Available We provide a recipe for “fattening” a category that leads to the construction of a double category. Motivated by an example where the underlying category has vector spaces as objects, we show how a monoidal category leads to a law of composition, satisfying certain coherence properties, on the object set of the fattened category.

  10. The Discovery of the Double Helix

    CERN Multimedia

    CERN. Geneva

    2011-01-01

    Professor James D. Watson has kindly agreed to make a presentation on the 1953 finding of the Double Helix at the Cavendish Laboratory by Francis Crick and himself. Being one of the greatest scientific discoveries in human history, little else needs to be added.

  11. Mandibular lateral incisor with four root canals: A unique case of double tooth diagnosed using multidetector computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Sunil Kumar; Acharya, Shashi Rashmi; Ather, Amber; Gupta, Jaya [Manipal College of Dental Sciences, Manipal University, Manipal (India)

    2013-06-15

    Double tooth is a dental anomaly consequent to fusion of two or more teeth or gemination of a single tooth. This report describes a unique case of double tooth in relation to a mandibular lateral incisor exhibiting the presence of four root canals. The role of conventional radiography and advanced three-dimensional imaging techniques in the better assessment of complex root canal systems and their aid in endodontic management has also been highlighted.

  12. Original article Role of Tamsulosin in Improving Double-J Ureteric ...

    African Journals Online (AJOL)

    2011-10-04

    Oct 4, 2011 ... quality of life (QoL) in patients with double-J (DJ) ureteric stents. Subjects and ... They were evaluated by history taking, clinical examination ... Quality of life was assessed by the QoL section of the IPSS and short form 36 (SF-36)6 questionnaire. The SF-36 assesses QoL in eight domains, including physical ...

  13. Refurbishment of single and double-glazed windows; Sanierung von einfach- und doppeltverglasten Fenstern

    Energy Technology Data Exchange (ETDEWEB)

    Eicher, H.; Erb, M.

    2001-01-15

    This report for the Swiss Federal Office of Energy (SFOE) as part of the research program on the efficient use of energy in buildings takes a look at the refurbishment of single and double-glazed windows. Topics examined include the assessment of window frame condition and the addition of seals as a cost-effective measure. Replacement of the window panes with various single and double glazing as well the installation of such glazing with special coatings is discussed. Further topics examined include the grey energy involved and noise protection aspects.

  14. Double Glow Plasma Surface Alloying Antibacterial Silver Coating on Pure Titanium

    Science.gov (United States)

    Lin, Naiming; Guo, Junwen; Hang, Ruiqiang; Zou, Jiaojuan; Tang, Bin

    2014-12-01

    In order to endow the commercial pure titanium dental implant material with antibacterial property and aimed at avoiding the invalidation that is caused by bacterial adhesion on the surface, a silver coating was fabricated via double glow plasma surface alloying. The antibacterial property of the silver coating was assessed via in vitro estimation. The results showed that a continuous and compact coating was formed. The silver coating had absolute superiority in antibacterial property to raw commercial pure titanium. Double glow plasma surface alloying with silver on commercial pure titanium dental implant material could be considered as a potentially effective method for preventing bacterial adhesion.

  15. Double-leg isometric exercise training in older men

    Directory of Open Access Journals (Sweden)

    Baross AW

    2013-01-01

    Full Text Available Anthony W Baross,1 Jonathan D Wiles,2 Ian L Swaine21Sport and Exercise Science, University of Northampton, Northampton, UK; 2Sport and Exercise Science, Canterbury Christ Church University, Canterbury, Kent, UKAbstract: Double-leg isometric training has been demonstrated to reduce resting blood pressure in young men when using electromyographic activity (EMG to regulate exercise intensity. This study assessed this training method in healthy older (45–60 years. men. Initially, 35 older men performed an incremental isometric exercise test to determine the linearity of the heart rate versus percentage peak EMG (%EMGpeak and systolic blood pressure versus %EMGpeak relationship. Thereafter, 20 participants were allocated to a training or control group. The training group performed three double-leg isometric sessions per week for 8 weeks, at 85% of peak heart rate. The training resulted in a significant reduction in resting systolic (11 ± 8 mmHg, P < 0.05 and mean arterial (5 ± 7 mmHg, P < 0.05 blood pressure. There was no significant change in resting systolic blood pressure for the control group or diastolic blood pressure in either group (all P > 0.05. These findings show that this training method, used previously in young men, is also effective in reducing resting systolic and mean arterial blood pressure in older men.Keywords: electromyography, resting blood pressure, heart rate

  16. Delivery of double singleton pregnancies in a woman with a double uterus, double cervix, and complete septate vagina

    Directory of Open Access Journals (Sweden)

    Ming-Jie Yang

    2015-12-01

    Full Text Available Uterine anomalies involving a double uterus, double cervix, also known as didelphys uterus, and complete septate vagina are rarely seen and have an associated fertility problem. However, artificial reproductive technology with embryo transfers can help solve this fertility challenge. Conception in the uterus in just one side is commonly seen for embryos, which are always transferred through the usually used (dilated vagina. We here present a patient with the above uterine anomaly who conceived with the aid of in vitro fertilization and embryo transfer to both uterine cavities under general anesthesia, which resulted in successful double singleton pregnancies with one fetus in each uterus. With intensive prenatal care, the pregnancy course for each fetus was rather uneventful. Although both fetuses were in cephalic presentation, cesarean section was performed at the 39th week of gestation with good outcomes in order to preclude anticipated difficulties if the baby had been delivered through the rarely dilated vagina. However, order of birth between the two fetuses was a crucial decision during the operation.

  17. 46 CFR 173.058 - Double bottom requirements.

    Science.gov (United States)

    2010-10-01

    ... PERTAINING TO VESSEL USE School Ships § 173.058 Double bottom requirements. Each new sailing school vessel... service must comply with the double bottom requirements in §§ 171.105 through 171.109, inclusive, of this...

  18. Heuristic Solution Approaches to the Double TSP with Multiple Stacks

    DEFF Research Database (Denmark)

    Petersen, Hanne Løhmann

    2006-01-01

    This paper introduces the Double Travelling Salesman Problem with Multiple Stacks and presents a three different metaheuristic approaches to its solution. The Double Travelling Salesman Problem with Multiple Stacks is concerned with finding the shortest route performing pickups and deliveries...

  19. Heuristic Solution Approaches to the Double TSP with Multiple Stacks

    DEFF Research Database (Denmark)

    Petersen, Hanne Løhmann

    This paper introduces the Double Travelling Salesman Problem with Multiple Stacks and presents a three different metaheuristic approaches to its solution. The Double Travelling Salesman Problem with Multiple Stacks is concerned with finding the shortest route performing pickups and deliveries...

  20. Double folding model analysis of elastic scattering of halo nucleus ...

    Indian Academy of Sciences (India)

    2014-04-17

    Coulomb barrier energy have been performed using a potential obtained from the double folding model and are compared with the experiment. In the framework of the double folding model, the nuclear matter densities of 9,10 ...

  1. Micrometer and CCD measurements of double stars (Series 51

    Directory of Open Access Journals (Sweden)

    Popović G.M.

    1998-01-01

    Full Text Available 36 micrometric measurements of 20 double or multiple systems carried out with the Zeiss 65/1055 cm Refractor of Belgrade Observatory are communicated. Also 35 CCD measurements of 15 double or multiple systems are included.

  2. Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice.

    Science.gov (United States)

    Jeoung, Nam Ho; Rahimi, Yasmeen; Wu, Pengfei; Lee, W N Paul; Harris, Robert A

    2012-05-01

    The importance of PDHK (pyruvate dehydrogenase kinase) 2 and 4 in regulation of the PDH complex (pyruvate dehydrogenase complex) was assessed in single- and double-knockout mice. PDHK2 deficiency caused higher PDH complex activity and lower blood glucose levels in the fed, but not the fasted, state. PDHK4 deficiency caused similar effects, but only after fasting. Double deficiency intensified these effects in both the fed and fasted states. PDHK2 deficiency had no effect on glucose tolerance, PDHK4 deficiency produced only a modest effect, but double deficiency caused a marked improvement and also induced lower insulin levels and increased insulin sensitivity. In spite of these beneficial effects, the double-knockout mice were more sensitive than wild-type and single-knockout mice to long-term fasting, succumbing to hypoglycaemia, ketoacidosis and hypothermia. Stable isotope flux analysis indicated that hypoglycaemia was due to a reduced rate of gluconeogenesis and that slightly more glucose was converted into ketone bodies in the double-knockout mice. The findings establish that PDHK2 is more important in the fed state, PDHK4 is more important in the fasted state, and survival during long-term fasting depends upon regulation of the PDH complex by both PDHK2 and PDHK4.

  3. Conventional En Masse Repair Versus Separate Double-Layer Double-Row Repair for the Treatment of Delaminated Rotator Cuff Tears.

    Science.gov (United States)

    Kim, Yang-Soo; Lee, Hyo-Jin; Jin, Hong-Ki; Kim, Sung-Eun; Lee, Jin-Woo

    2016-05-01

    The rotator cuff tendon is known to exert a shear force between the superficial and deep layers. Owing to this characteristic, separate repair of delaminated rotator cuff tears has been introduced for the restoration of the physiological biomechanics of the rotator cuff. However, whether conventional en masse repair or separate repair is superior is controversial in terms of outcomes. To compare clinical outcomes between conventional en masse repair and separate double-layer double-row repair for the treatment of delaminated rotator cuff tears. Randomized controlled study; Level of evidence, 2. Between August 2007 and March 2014, a total of 82 patients who underwent arthroscopic rotator cuff repair of a delaminated tear were enrolled and randomized into 2 groups. In group 1 (n = 48), arthroscopic conventional en masse repair was performed. In group 2 (n = 34), separate double-layer double-row repair was performed. The American Shoulder and Elbow Surgeons score, Constant score, Simple Shoulder Test score, and visual analog scale (VAS) score for pain and range of motion (ROM) were assessed before surgery; at 3, 6, and 12 months after surgery; and at the last follow-up visit. Magnetic resonance imaging (MRI) was performed at 12 months postoperatively to examine the retear rate and pattern. There was no significant difference between groups in the preoperative demographic data, including patient age, sex, symptom duration, tear size, and functional scores (P > .05). The mean follow-up period was 25.9 ± 1.2 months. Significant improvements in functional and pain scores were observed in both groups at the last follow-up visit. However, no significant differences in functional scores and ROM were found between the 2 groups at each time point, except that group 2 had significantly lower VAS pain scores (P .05). Both conventional en masse repair and separate double-layer double-row repair were effective in improving clinical outcomes in the treatment of delaminated rotator

  4. Boltzmann equation with double-well potentials

    Science.gov (United States)

    Chiacchiera, Silvia; Macrı, Tommaso; Trombettoni, Andrea

    2016-10-01

    We study the dynamics of an interacting classical gas trapped in a double-well potential at finite temperature. Two model potentials are considered: a cubic box with a square barrier in the middle, and a harmonic trap with a Gaussian barrier along one direction. The study is performed using the Boltzmann equation, solved numerically via the test-particle method. We introduce and discuss a simple analytical model that allows one to provide estimates of the relaxation time, which are compared with numerical results. Finally, we use our findings to make numerical and analytical predictions for the case of a fermionic mixture in the normal-fluid phase in a realistic double-well potential relevant for experiments with cold atoms.

  5. Phonon tunneling through a double barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Villegas, Diosdado [Departamento de Física, Universidad Central “Marta Abreu” de Las Villas, CP 54830, Santa Clara, Villa Clara (Cuba); Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico); León-Pérez, Fernando de [Centro Universitario de la Defensa de Zaragoza, Ctra. de Huesca s/n, E-50090 Zaragoza (Spain); Pérez-Álvarez, R. [Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209 Cuernavaca (Mexico); Arriaga, J., E-mail: arriaga@ifuap.buap.mx [Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico)

    2015-04-15

    The tunneling of optical and acoustic phonons at normal incidence on a double-barrier is studied in this paper. Transmission coefficients and resonance conditions are derived theoretically under the assumption that the long-wavelength approximation is valid. It is shown that the behavior of the transmission coefficients for the symmetric double barrier has a Lorentzian form close to resonant frequencies and that Breit–Wigner's formula have a general validity in one-dimensional phonon tunneling. Authors also study the so-called generalized Hartman effect in the tunneling of long-wavelength phonons and show that this effect is a numerical artifact resulting from taking the opaque limit before exploring the variation with a finite barrier width. This study could be useful for the design of acoustic devices.

  6. The DNA double helix fifty years on.

    Science.gov (United States)

    Macgregor, Robert B; Poon, Gregory M K

    2003-10-01

    This year marks the 50th anniversary of the proposal of a double helical structure for DNA by James Watson and Francis Crick. The place of this proposal in the history and development of molecular biology is discussed. Several other discoveries that occurred in the middle of the twentieth century were perhaps equally important to our understanding of cellular processes; however, none of these captured the attention and imagination of the public to the same extent as the double helix. The existence of multiple forms of DNA and the uses of DNA in biological technologies is presented. DNA is also finding increasing use as a material due to its rather unusual structural and physical characteristics as well as its ready availability.

  7. Quantum capacitance of double-layer graphene

    Science.gov (United States)

    Parhizgar, Fariborz; Qaiumzadeh, Alireza; Asgari, Reza

    2017-08-01

    We study the ground-state properties of a double-layer graphene system with the Coulomb interlayer electron-electron interaction modeled within the random-phase approximation. We first obtain an expression of the quantum capacitance of a two-layer system. In addition, we calculate the many-body exchange-correlation energy and quantum capacitance of the hybrid double-layer graphene system at zero temperature. We show an enhancement of the majority density layer thermodynamic density of states owing to an increasing interlayer interaction between two layers near the Dirac point. The quantum capacitance near the neutrality point behaves like a square root of the total density α √{n } where the coefficient α decreases by increasing the charge-density imbalance between two layers. Furthermore, we show that the quantum capacitance changes linearly by the gate voltage. Our results can be verified by current experiments.

  8. Towards weakly constrained double field theory

    Directory of Open Access Journals (Sweden)

    Kanghoon Lee

    2016-08-01

    Full Text Available We show that it is possible to construct a well-defined effective field theory incorporating string winding modes without using strong constraint in double field theory. We show that X-ray (Radon transform on a torus is well-suited for describing weakly constrained double fields, and any weakly constrained fields are represented as a sum of strongly constrained fields. Using inverse X-ray transform we define a novel binary operation which is compatible with the level matching constraint. Based on this formalism, we construct a consistent gauge transform and gauge invariant action without using strong constraint. We then discuss the relation of our result to the closed string field theory. Our construction suggests that there exists an effective field theory description for massless sector of closed string field theory on a torus in an associative truncation.

  9. Double Beta Decay Experiments with Thermal Detectors

    Science.gov (United States)

    Alessandrello, A.; Brofferio, C.; Cremonesi, O.; Fiorini, E.; Giuliani, A.; Nucciotti, A.; Pavan, M.; Pessina, G.; Pirro, S.; Previtali, E.; Vanzini, M.; Zanotti, L.; Bucci, C.

    2001-05-01

    Massive low temperature particle detectors and their possible impacts on searches for neutrinoless double beta decay (O-DBD) are presented and discussed. In particular, the experimental work of the Milano group is described. Special relevance is given to the present status of the search for O-DBD of 130Te and to the possible expansion of this experiment in the near future. The most recent results obtained by the Milano-Gran Sasso collaboration with a 20 bolometer array are presented. On the basis of these results, the construction of a 42 kg array consisting of 56 TeO2 bolometers (CUORICINO project), to extend the sensitivity of the present experiment, has been proposed. CUORICINO should represent also a feasibility test for a large array of 1000 bolometers (CUORE project) aiming at the search for neutrinoless Double Beta Decay, Cold Dark Matter and Solar Axions with extremely high sensitivity.

  10. Double Image Design in Newspaper Production

    Directory of Open Access Journals (Sweden)

    Mario Barišić

    2010-01-01

    Full Text Available In the high circulation production of daily newspapers, a double image, double information is set under the rules of Infraredesign theory (Pap et al, 2010. The management of visible and near infrared is posted with process colors for color setting configured for conventional newspaper print. The place of imprint that has delimited information in vs (Visible Spectrum and nir (Near InfraRed is called “a print with an infrared effect,” or conditionally “a print with infrared colors.” Daily newspapers, as massive carriers of information made by printing technique, are receiving a new form of presentation: printed image with a built-in invisible image.

  11. Double papilla flap technique for dual purpose

    Directory of Open Access Journals (Sweden)

    P Mohan Kumar

    2012-01-01

    Full Text Available Marginal tissue recession exposes the anatomic root on the teeth, which gives rise to -common patient complaints. It is associated with sensitivity, tissue irritation, cervical abrasions, and esthetic concerns. Various types of soft tissue grafts may be performed when recession is deep and marginal tissue health cannot be maintained. Double papilla flap is an alternative technique to cover isolated recessions and correct gingival defects in areas of insufficient attached gingiva, not suitable for a lateral sliding flap. This technique offers the advantages of dual blood supply and denudation of interdental bone only, which is less susceptible to permanent damage after surgical exposure. It also offers the advantage of quicker healing in the donor site and reduces the risk of facial bone height loss. This case report presents the advantages of double papilla flap in enhancing esthetic and functional outcome of the patient.

  12. Amplitude determinant coupled cluster with pairwise doubles

    CERN Document Server

    Zhao, Luning

    2016-01-01

    Recently developed pair coupled cluster doubles (pCCD) theory successfully reproduces doubly occupied configuration interaction (DOCI) with mean field cost. However, the projective nature of pCCD makes the method non-variational and thus hard to improve systematically. As a variational alternative, we explore the idea of coupled-cluster-like expansions based on amplitude determinants and develop a specific theory similar to pCCD based on determinants of pairwise doubles. The new ansatz admits a variational treatment through Monte Carlo methods while remaining size-consistent and, crucially, polynomial cost. In the dissociations of LiH, HF, H2O and N2, the method performs very similarly to pCCD and DOCI, suggesting that coupled-cluster-like ansatzes and variational evaluation may not be mutually exclusive.

  13. Xanthogranulomatous Pyelonephritis with Incomplete Double Ureter

    Directory of Open Access Journals (Sweden)

    Yutaro Hayashi

    2017-01-01

    Full Text Available Introduction. Xanthogranulomatous pyelonephritis (XGP is a type of chronic renal inflammation that usually occurs in immunocompromised middle-aged women with chronic urinary tract infection or ureteral obstruction induced by the formation of ureteral stones. XGP with an incomplete double ureter is extremely rare. Case Presentation. A 76-year-old woman was referred to our department to undergo further examination for a left renal tumor that was detected by ultrasonography. Dynamic contrast computed tomography (CT revealed an enhanced tumor in the upper renal parenchyma. Laparoscopic radical nephrectomy was performed based on a preoperative diagnosis of renal cell carcinoma. Histological sections showed the aggregation of foam cells; thus, XGP was diagnosed. Conclusion. We herein report a rare case of XGP in the upper pole of the kidney, which might have been associated with an incomplete double ureter.

  14. Inviscid double wake model for stalled airfoils

    DEFF Research Database (Denmark)

    Marion, Lucas; Ramos García, Néstor; Sørensen, Jens Nørkær

    2014-01-01

    An inviscid double wake model based on a steady two-dimensional panel method has been developed to predict aerodynamic loads of wind turbine airfoils in the deep stall region. The separated flow is modelled using two constant vorticity sheets which are released at the trailing edge and at the sep......An inviscid double wake model based on a steady two-dimensional panel method has been developed to predict aerodynamic loads of wind turbine airfoils in the deep stall region. The separated flow is modelled using two constant vorticity sheets which are released at the trailing edge...... and at the separation point. A calibration of the code through comparison with experiments has been performed using one set of airfoils. A second set of airfoils has been used for the validation of the calibrated model. Predicted aerodynamic forces for a wide range of angles of attack (0 to 90 deg) are in overall good...

  15. Detecting double compression of audio signal

    Science.gov (United States)

    Yang, Rui; Shi, Yun Q.; Huang, Jiwu

    2010-01-01

    MP3 is the most popular audio format nowadays in our daily life, for example music downloaded from the Internet and file saved in the digital recorder are often in MP3 format. However, low bitrate MP3s are often transcoded to high bitrate since high bitrate ones are of high commercial value. Also audio recording in digital recorder can be doctored easily by pervasive audio editing software. This paper presents two methods for the detection of double MP3 compression. The methods are essential for finding out fake-quality MP3 and audio forensics. The proposed methods use support vector machine classifiers with feature vectors formed by the distributions of the first digits of the quantized MDCT (modified discrete cosine transform) coefficients. Extensive experiments demonstrate the effectiveness of the proposed methods. To the best of our knowledge, this piece of work is the first one to detect double compression of audio signal.

  16. Energy Calibration of Double Chooz Detector

    Science.gov (United States)

    Yang, Guang

    2013-04-01

    Reactor anti-neutrino oscillation experiment Double Chooz was designed to measure the mixing angle theta-13 with unprecedented sensitivity. The Double Chooz detector system consists of a main detector, an outer veto system and several calibration systems. The main detector has a cylindrical structure. It consists of the target vessel, a liquid scintillator loaded with Gd, surrounded by the gamma-catcher, a non-loaded liquid scintillator. A buffer region of non-scintillating liquid surrounds the gamma-catcher and serves to host 390 photomultiplier tubes and to decrease the level of accidental background. The Inner Veto region is outside the buffer, and the Outer Veto system covers all detector components. Far detector is operational and the near detector is under construction. The detector is calibrated with light sources, radioactive point sources, cosmics and natural radioactivity. In this presentation we will describe use of radioactive calibration sources and cross-checks performed with cosmics and natural radioactivity.

  17. Double quantum dots in carbon nanotubes

    Science.gov (United States)

    von Stecher, Javier; Wunsch, Bernhard; Lukin, Mikhail; Demler, Eugene; Rey, Ana Maria

    2010-03-01

    We study the behavior of few-electrons confined in a double-well quantum dot in semiconducting carbon nanotubes. These carbon nanostructures exhibit richer physics than GaAs ones due to the additional valley degree of freedom. We calculate and characterize the low energy eigenstates in the presence of a magnetic field and double-well detuning. Spin-orbit coupling lifts the spin and valley degeneracy and, in the presence of exchange interactions, leads, at small detunings and weak magnetic fields, to a spin-valley antisymmetric two-electron ground state which is not a pure spin-singlet state. At large detuning, the strong Coulomb interactions accessible in carbon nanotubes can substantially modify the non-interacting eigenstates via higher orbital-level mixing. The latter manifest in current transport experiments by the disappearance of the Pauli blockade.

  18. Monitoring of Double Stud Wall Moisture Conditions in the Northeast

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, K. [Building Science Corporation, Westford, MA (United States)

    2015-03-01

    Double-stud walls insulated with cellulose or low-density spray foam can have R-values of 40 or higher. However, double stud walls have a higher risk of interior-sourced condensation moisture damage, when compared with high-R approaches using exterior insulating sheathing.; Moisture conditions in double stud walls were monitored in Zone 5A (Massachusetts); three double stud assemblies were compared.

  19. Maxillary double lip: A case series with review of literature

    Directory of Open Access Journals (Sweden)

    Vela D Desai

    2015-01-01

    Full Text Available Double lip is a rare dental anomaly affecting either upper or lower lip or concurrently. It may be congenital or acquired. This deformity can affect the facial esthetics as it gets exaggerated while speaking, smiling, or chewing food. When it interferes with speech, double lip may cause potential functional problems. The purpose of this article is to review the literature on double lip and present a case series of maxillary double lip.

  20. A double patella-like condition secondary to synovial osteochondromatosis

    Directory of Open Access Journals (Sweden)

    Kajikawa Yoshiteru

    2012-09-01

    Full Text Available Abstract To our knowledge, this is the first case of synovial osteochondromatosis in a patient presenting with a double patella-like condition. The true duplication of the patella, which is called double patella, is extremely rare. In our case, the operative and histopathological findings showed that the double patella-like condition was secondarily induced by synovial osteochondromatosis. Synovial osteochondromatosis should be considered as a differential diagnosis for congenital double patella.

  1. [Double gall blader--surprise during operation].

    Science.gov (United States)

    Oprea, D; Maier, A; Costea, P

    2010-01-01

    Gall blader abnormalities are very rare. The diagnosis is difficult, more often appears during operation or necropsy. The authors present a clinical case with double gall blader, into a 50 years old man. The diagnosis appeared during laparoscopic cholecystectomy. The colecistectomy was performed for chronic cholelithiasis. Even it is rare, this pathology should be known, to avoid biliary ducts iatrogenic injuries during operations. The authors made a mustering of literature.

  2. Floral double mesiodentes: A rare case report.

    Science.gov (United States)

    Singaraju, Gowri Sankar; Reddy, B Rama Mohan; Supraja, G; Reddy, K Narayana

    2015-01-01

    Mesiodens is the most commonly erupting supernumerary in the midline between two maxillary central incisors. Mesiodentes is a rare condition when mesiodens erupt in multiples, which may present as either labial or palatal to permanent central incisors. We report a rare case of double mesiodentes (non-syndromic mesiodentes) with floret like appearance. The presence of mesiodens has functional and esthetic implications. Careful radiographic evaluation should be done to prevent complications during their extraction.

  3. Tables of double beta decay data

    Energy Technology Data Exchange (ETDEWEB)

    Tretyak, V.I. [AN Ukrainskoj SSR, Kiev (Ukraine)]|[Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires; Zdesenko, Y.G. [AN Ukrainskoj SSR, Kiev (Ukraine)

    1995-12-31

    A compilation of experimental data on double beta decay is presented. The tables contain the most stringent known experimental limits or positive results of 2{beta} transitions of 69 natural nuclides to ground and excited states of daughter nuclei for different channels (2{beta}{sup -}; 2{beta}{sup +}; {epsilon}{beta}{sup +}; 2{epsilon}) and modes (0{nu}; 2{nu}; 0{nu}M) of decay. (authors). 189 refs., 9 figs., 3 tabs.

  4. Doubling Time for Nonexponential Families of Functions

    Science.gov (United States)

    Gordon, Sheldon P.

    2010-01-01

    One special characteristic of any exponential growth or decay function f(t) = Ab[superscript t] is its unique doubling time or half-life, each of which depends only on the base "b". The half-life is used to characterize the rate of decay of any radioactive substance or the rate at which the level of a medication in the bloodstream decays as it is…

  5. Vitrectomy in double-perforation gunshot injury

    Directory of Open Access Journals (Sweden)

    Abd El Alim Mohamed A

    2013-11-01

    Full Text Available Ahmed Abd El Alim MohamedOphthalmology department, Ain Shams University, Cairo, EgyptObjective: This study sought to evaluate the result of pars plana vitrectomy in patients with gunshot wounds involving double perforation.Methods: This was a retrospective, noncomparative, interventional case series.Results: Eighteen patients (18 eyes with double-perforation gunshot injuries were treated from February 2010 to March 2012. The group included 16 men (88% and two women (11%; the mean age was 24 (15–33 years. In each case, vitrectomy was scheduled 1–6 weeks after repair of the entrance site. Associated retinal detachments were observed in two eyes (11%, retinal incarceration was observed surrounding the exit site in three eyes (16%, and retention of an intraocular foreign body was observed in two cases. After a follow-up period of 8 ± 2 months, two eyes (11% had achieved visual acuity (VA of 0.5, nine eyes (50% had achieved VA between 0.5 and 0.1, and seven eyes (38% had achieved VA between 0.1 and hand movement. The main reasons for functional failure (VA 0.1 to hand movement were macular dragging (due to fibrosis at the exit site near the macula in seven cases (38%, submacular hemorrhage in four cases (22%, and epimacular fibrosis in five cases (27%. All cases developed postoperative exotropia. One case (5% developed postoperative hemorrhage. No cases exhibited signs of postoperative redetachment.Conclusion: The outcome of pars plana vitrectomy in cases with double perforations is variable. Factors including the surgeon's skill level, the time to surgery, and the efficacy of the intraocular tamponade affect the postoperative outcome.Keywords: pars plana vitrectomy, gunshot injury, double perforation

  6. Nivolumab Doubles Survival for Patients with HNSCC.

    Science.gov (United States)

    2016-07-01

    In patients with head and neck squamous cell carcinoma refractory to platinum-based chemotherapy, those treated with nivolumab had a 30% reduction in the risk of death compared with those assigned to receive one of three single-agent chemotherapies, according to a recent phase III trial. In addition, 1-year survival among nivolumab recipients was double that of those who received a chemotherapeutic, the current standard of care. ©2016 American Association for Cancer Research.

  7. The double helix and the 'wronged heroine'.

    Science.gov (United States)

    Maddox, Brenda

    2003-01-23

    In 1962, James Watson, Francis Crick and Maurice Wilkins received the Nobel prize for the discovery of the structure of DNA. Notably absent from the podium was Rosalind Franklin, whose X-ray photographs of DNA contributed directly to the discovery of the double helix. Franklin's premature death, combined with misogynist treatment by the male scientific establishment, cast her as a feminist icon. This myth overshadowed her intellectual strength and independence both as a scientist and as an individual.

  8. Integrated double-sided silicon microstrip detectors

    Directory of Open Access Journals (Sweden)

    Perevertailo V. L.

    2011-11-01

    Full Text Available The problems of design, technology and manufacturing double-sided silicon microstrip detectors using standard equipment production line in mass production of silicon integrated circuits are considered. The design of prototype high-energy particles detector for experiment ALICE (CERN is presented. The parameters of fabricated detectors are comparable with those of similar foreign detectors, but they are distinguished by lesser cost.

  9. Double-Diffusive Convection in Rotational Shear

    Science.gov (United States)

    2015-03-01

    have already been conducted to test the distortion of thermohaline 49 staircases and the channel propagation of acoustic signals (Bulters, 2013...models of ocean circulation (Radko 2013). In each of these instances, a clearer understanding of the small-scale dynamics of double diffusion would...REFERENCES Bulters, A. C., 2012: Three-dimensional structure of thermohaline staircases in the tropical north Atlantic and their effect on acoustic

  10. Efficacy of pneumococcal nontypable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in young Latin American children: A double-blind randomized controlled trial

    National Research Council Canada - National Science Library

    Tregnaghi, Miguel W; Sáez-Llorens, Xavier; López, Pio; Abate, Hector; Smith, Enrique; Pósleman, Adriana; Calvo, Arlene; Wong, Digna; Cortes-Barbosa, Carlos; Ceballos, Ana; Tregnaghi, Marcelo; Sierra, Alexandra; Rodriguez, Mirna; Troitiño, Marisol; Carabajal, Carlos; Falaschi, Andrea; Leandro, Ana; Castrejón, Maria Mercedes; Lepetic, Alejandro; Lommel, Patricia; Hausdorff, William P; Borys, Dorota; Ruiz Guiñazú, Javier; Ortega-Barría, Eduardo; Yarzábal, Juan P; Schuerman, Lode

    2014-01-01

    ...); other protocol-specified outcomes were also assessed. This phase III double-blind randomized controlled study was conducted between 28 June 2007 and 28 July 2011 in Argentine, Panamanian, and Colombian populations with good access to health care...

  11. Double segmental tibial fractures - an unusual fracture pattern

    Directory of Open Access Journals (Sweden)

    Bali Kamal

    2012-02-01

    Full Text Available 【Abstract】A case of a 50-year-old pedestrian who was hit by a bike and suffered fractures of both bones of his right leg was presented. Complete clinical and radiographic assessment showed double segmental fractures of the tibia and multisegmental fractures of the fibula. Review of the literature revealed that this fracture pattern was unique and only a single case was reported so far. Moreover, we discussed the possible mechanisms which can lead to such an injury. We also discussed the management of segmental tibial fracture and the difficulties encountered with them. This case was managed by modern osteosynthesis tech- nique with a pleasing outcome. Key words: Fracture, bone; Tibia; Fibula; Nails

  12. Biological evaluation of layered double hydroxides as efficient drug vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Li Yan; Liu Dan; Chang Qing; Liu Dandan; Xia Ying; Liu Shuwen; Peng Nanfang; Yang Xu [Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan 430079 (China); Ai Hanhua [College of Physical Science and Technology, Huazhong Normal University, Wuhan 430079 (China); Xi Zhuge, E-mail: yangxu@mail.ccnu.edu.cn [Tianjin Institutes of Health and Environmental Medicine, Tianjin 300050 (China)

    2010-03-12

    Recently there has been a rapid expansion of the development of bioinorganic hybrid systems for safe drug delivery. Layered double hydroxides (LDH), a variety of available inorganic matrix, possess great promise for this purpose. In this study, an oxidative stress biomarker system, including measurement of reactive oxygen species, glutathione content, endogenous nitric oxide, carbonyl content in proteins, DNA strand breaks and DNA-protein crosslinks, was designed to evaluate the biocompatibility of different concentrations of nano-Zn/Al-LDH with a Hela cell line. The drug delivery activity of the LDH-folic-acid complex was also assessed. The resulting data clearly demonstrated that nano-LDH could be applied as a relatively safe drug vehicle with good delivery activity, but with the caveat that the effects of high dosages observed here should not be ignored when attempting to maximize therapeutic activity by increasing LDH concentration.

  13. A facile one-step strategy for development of a double network fibrous scaffold for nerve tissue engineering.

    Science.gov (United States)

    Golafshan, Nasim; Gharibi, Hamidreza; Kharaziha, Mahshid; Fathi, Mohammadhossein

    2017-04-28

    The aim of this study was to develop a novel double network scaffold composed of polycaprolactone fumarate (PCLF) and eggshell membrane (ESM) (ESM:PCLF) by using the vacuum infiltration method. Compared to ESM, the mechanical properties of double network scaffold were significantly improved, depending on the solvents applied for double network scaffold formation; acetic acid and dichloromethane. Noticeably, the toughness and strength of double network scaffold prepared using acetic acid were significantly improved compared to ESM (26.6 and 25 times, respectively) attributed to the existence of hydrophilic functional groups in acetic acid which made ESM flexible to absorb further PCLF solution. To assess the effect of double network formation on the biological behavior of ESM, the attachment, proliferation and spreading of PC12 cells cultured on the ESM:PCLF scaffolds were evaluated. Results revealed that the number of cells attached on double network ESM:PCLF scaffold were nearly similar to ESM and significantly higher than that of on the tissue culture plate (2.6 times) and PCLF film (1.7 times). It is envisioned that the offered ESM:PCLF double network scaffold might have great potential to develop the constructs for nerve regeneration.

  14. Double versus single reading of mammograms in a breast cancer screening programme: a cost-consequence analysis.

    Science.gov (United States)

    Posso, Margarita C; Puig, Teresa; Quintana, Ma Jesus; Solà-Roca, Judit; Bonfill, Xavier

    2016-09-01

    To assess the costs and health-related outcomes of double versus single reading of digital mammograms in a breast cancer screening programme. Based on data from 57,157 digital screening mammograms from women aged 50-69 years, we compared costs, false-positive results, positive predictive value and cancer detection rate using four reading strategies: double reading with and without consensus and arbitration, and single reading with first reader only and second reader only. Four highly trained radiologists read the mammograms. Double reading with consensus and arbitration was 15 % (Euro 334,341) more expensive than single reading with first reader only. False-positive results were more frequent at double reading with consensus and arbitration than at single reading with first reader only (4.5 % and 4.2 %, respectively; p screens; p = 0.283). Our results suggest that changing to single reading of mammograms could produce savings in breast cancer screening. Single reading could reduce the frequency of false-positive results without changing the cancer detection rate. These results are not conclusive and cannot be generalized to other contexts with less trained radiologists. • Double reading of digital mammograms is more expensive than single reading. • Compared to single reading, double reading yields a higher proportion of false-positive results. • The cancer detection rate was similar for double and single readings. • Single reading may be a cost-effective strategy in breast cancer screening programmes.

  15. Why double-stranded RNA resists condensation

    Science.gov (United States)

    Tolokh, Igor S.; Pabit, Suzette A.; Katz, Andrea M.; Chen, Yujie; Drozdetski, Aleksander; Baker, Nathan; Pollack, Lois; Onufriev, Alexey V.

    2014-01-01

    The addition of small amounts of multivalent cations to solutions containing double-stranded DNA leads to inter-DNA attraction and eventual condensation. Surprisingly, the condensation is suppressed in double-stranded RNA, which carries the same negative charge as DNA, but assumes a different double helical form. Here, we combine experiment and atomistic simulations to propose a mechanism that explains the variations in condensation of short (25 base-pairs) nucleic acid (NA) duplexes, from B-like form of homopolymeric DNA, to mixed sequence DNA, to DNA:RNA hybrid, to A-like RNA. Circular dichroism measurements suggest that duplex helical geometry is not the fundamental property that ultimately determines the observed differences in condensation. Instead, these differences are governed by the spatial variation of cobalt hexammine (CoHex) binding to NA. There are two major NA-CoHex binding modes—internal and external—distinguished by the proximity of bound CoHex to the helical axis. We find a significant difference, up to 5-fold, in the fraction of ions bound to the external surfaces of the different NA constructs studied. NA condensation propensity is determined by the fraction of CoHex ions in the external binding mode. PMID:25123663

  16. Double shell planar experiments on OMEGA

    Science.gov (United States)

    Dodd, E. S.; Merritt, E. C.; Palaniyappan, S.; Montgomery, D. S.; Daughton, W. S.; Schmidt, D. W.; Cardenas, T.; Wilson, D. C.; Loomis, E. N.; Batha, S. H.; Ping, Y.; Smalyuk, V. A.; Amendt, P. A.

    2017-10-01

    The double shell project is aimed at fielding neutron-producing capsules at the National Ignition Facility (NIF), in which an outer low-Z ablator collides with an inner high-Z shell to compress the fuel. However, understanding these targets experimentally can be challenging when compared with conventional single shell targets. Halfraum-driven planar targets at OMEGA are being used to study physics issues important to double shell implosions outside of a convergent geometry. Both VISAR and radiography through a tube have advantages over imaging through the hohlraum and double-shell capsule at NIF. A number physics issues are being studied with this platform that include 1-d and higher dimensional effects such as defect-driven hydrodynamic instabilities from engineering features. Additionally, the use of novel materials with controlled density gradients require study in easily diagnosed 1-d systems. This work ultimately feeds back into the NIF capsule platform through manufacturing tolerances set using data from OMEGA. Supported under the US DOE by the LANS, LLC under contract DE-AC52-06NA25396. LA-UR-17-25386.

  17. The 'double cortex' syndrome on MRI.

    Science.gov (United States)

    Hashimoto, R; Seki, T; Takuma, Y; Suzuki, N

    1993-01-01

    We report a 6-year-old girl with diffuse subcortical heterotopia (band heterotopia), an unusual type of ectopic gray matter on magnetic resonance imaging (MRI). Her cerebral parenchyma had four layers consisting of cortex, thin outer white matter, diffuse subcortical heterotopia, and inner white matter around the lateral ventricles, giving the appearance of a 'double cortex'. The overlying cortex had midly broad gyri, especially in the frontal lobes. MRI showed the appearance of laminar heterotopia, a classical pathological entity. The double cortex syndrome is presumably a radiological delineation of laminar heterotopia. Her development was slightly delayed and she was clumsy and easily upset, with poor impulse control. However, her daily life was largely unaffected in spite of the severe abnormalities on MRI. She had abnormal movements during sleep, and sleeping EEG showed high voltage spindles in the bilateral frontal areas but no epileptic discharges. It could not be determined whether or not these movements were epileptic. The double cortex syndrome, an anomaly of the central nervous system associated with mental retardation, epilepsy, behavioral problems, and exclusive occurrence in girls, will be established as a clinico-radiological entity.

  18. Aerodynamic Analysis Over Double Wedge Airfoil

    Science.gov (United States)

    Prasad, U. S.; Ajay, V. S.; Rajat, R. H.; Samanyu, S.

    2017-05-01

    Aeronautical studies are being focused more towards supersonic flights and methods to attain a better and safer flight with highest possible performance. Aerodynamic analysis is part of the whole procedure, which includes focusing on airfoil shapes which will permit sustained flight of aircraft at these speeds. Airfoil shapes differ based on the applications, hence the airfoil shapes considered for supersonic speeds are different from the ones considered for Subsonic. The present work is based on the effects of change in physical parameter for the Double wedge airfoil. Mach number range taken is for transonic and supersonic. Physical parameters considered for the Double wedge case with wedge angle (ranging from 5 degree to 15 degree. Available Computational tools are utilized for analysis. Double wedge airfoil is analysed at different Angles of attack (AOA) based on the wedge angle. Analysis is carried out using fluent at standard conditions with specific heat ratio taken as 1.4. Manual calculations for oblique shock properties are calculated with the help of Microsoft excel. MATLAB is used to form a code for obtaining shock angle with Mach number and wedge angle at the given parameters. Results obtained from manual calculations and fluent analysis are cross checked.

  19. Academic knowing in/through double perspectives

    Directory of Open Access Journals (Sweden)

    Margareta Melin

    2015-12-01

    Full Text Available This article explores the cultures and learning practices of four academic schools with an expressed wish to bridge the gap between traditional academic and arts or journalistic practices. Pierre Bourdieu, the French sociologist, termed them allodoxic, in that they challenge the traditional academic way of thinking and doing. Results from two research projects, spanning over 5 years, employing a multitude of methods, have been used in this article. The results show that these challenging bridging attempts create conflictual cultures. First, faculties with different backgrounds are employed and they bring with them their respective habitus and doxa (Bourdieu, which is manifested in their different epistemologies, doxas. Despite a strong will to work interdisciplinarily, conflicts (destructive arise particularly around epistemological and pedagogic issues. Second, I show that students at these schools have had double-perspective learning, through theoretical and practice-based methods, despite little help from their lecturers who have high ideals but little actual knowledge themselves of working in/through a double perspective. In many cases, through trial-and-error processes, students have appropriated embodied knowledge of a double perspective, which has given them surplus value when compared with learning through only traditional academic learning practices. It gives reflexive insights and understandings as well as transferrable skills highly useful in professional life. I finally argue that allodoxic conflictual cultures actually construct new ways of knowing through continuous discussions and meetings between faculties with different competences.

  20. Double entry bookkeeping vs single entry bookkeeping

    Directory of Open Access Journals (Sweden)

    Ileana Andreica

    2016-11-01

    Full Text Available Abstract: A financial management eficiently begin, primarily, with an accounting record kept in the best possible conditions, this being conditioned on the adoption of a uniform forms, rational, clear and simple accounting. Throughout history, there have been known two forms of accounting: the simple and double entry. Romanian society after 1990 underwent a substantial change in social structure, the sector on which put a great emphasis being private, that of small manufacturers, peddler, freelance, who work independently and authorized or as associative form (family enterprises, various associations (owners, tenants, etc., liberal professions, etc.. They are obliged to keep a simple bookkeeping, because they have no juridical personality. Companies with legal personality are required to keep double entry bookkeeping; therefore, knowledge and border demarcation between the two forms of organisation of accounting is an essential. The material used for this work is mainly represented by the financial and accounting documents, by the analysis of the economic, by legislative updated sources, and as the method was used the comparison method, using hypothetical data, in case of an authorized individual and a legal entity. Based on the chosen material, an authorized individual (who perform single entry accounting system and a juridical entity (who perform double entry accounting system were selected comparative case studies, using hypothetical data, were analysed advantages and disadvantages in term of fiscal, if using two accounting systems, then were highlighted some conclusion that result.

  1. Perturbative quantum gravity in double field theory

    Energy Technology Data Exchange (ETDEWEB)

    Boels, Rutger H.; Horst, Christoph [II. Institut für Theoretische Physik, Universität Hamburg,Luruper Chaussee 149, D- 22761 Hamburg (Germany)

    2016-04-19

    We study perturbative general relativity with a two-form and a dilaton using the double field theory formulation which features explicit index factorisation at the Lagrangian level. Explicit checks to known tree level results are performed. In a natural covariant gauge a ghost-like scalar which contributes even at tree level is shown to decouple consistently as required by perturbative unitarity. In addition, a lightcone gauge is explored which bypasses the problem altogether. Using this gauge to study BCFW on-shell recursion, we can show that most of the D-dimensional tree level S-matrix of the theory, including all pure graviton scattering amplitudes, is reproduced by the double field theory. More generally, we argue that the integrand may be reconstructed from its single cuts and provide limited evidence for off-shell cancellations in the Feynman graphs. As a straightforward application of the developed technology double field theory-like expressions for four field string corrections are derived.

  2. Double-Difference Tomography for Sequestration MVA

    Energy Technology Data Exchange (ETDEWEB)

    Westman, Erik

    2008-12-31

    Analysis of synthetic data was performed to determine the most cost-effective tomographic monitoring system for a geologic carbon sequestration injection site. Double-difference tomographic inversion was performed on 125 synthetic data sets: five stages of CO2 plume growth, five seismic event regions, and five geophone arrays. Each resulting velocity model was compared quantitatively to its respective synthetic velocity model to determine an accuracy value. The results were examined to determine a relationship between cost and accuracy in monitoring, verification, and accounting applications using double-difference tomography. The geophone arrays with widely-varying geophone locations, both laterally and vertically, performed best. Additionally, double difference seismic tomography was performed using travel time data from a carbon sequestration site at the Aneth oil field in southeast Utah as part of a Department of Energy initiative on monitoring, verification, and accounting (MVA) of sequestered CO2. A total of 1,211 seismic events were recorded from a borehole array consisting of 22 geophones. Artificial velocity models were created to determine the ease with which different CO2 plume locations and sizes can be detected. Most likely because of the poor geophone arrangement, a low velocity zone in the Desert Creek reservoir can only be detected when regions of test site containing the highest ray path coverage are considered. MVA accuracy and precision may be improved through the use of a receiver array that provides more comprehensive ray path coverage.

  3. Visual mislocalization during double-step saccades

    Directory of Open Access Journals (Sweden)

    Eckart eZimmermann

    2015-10-01

    Full Text Available Visual objects presented briefly at the time of saccade onset appear compressed toward the saccade target. Compression strength depends on the presentation of a visual saccade target signal and is strongly reduced during the second saccade of a double-step saccade sequence (Zimmermann et al., 2014; 2014. Here, I tested whether perisaccadic compression is linked to saccade planning by contrasting two double-step paradigms. In the same-direction double-step paradigm, subjects were required to perform two rightward 10° saccades successively. At various times around execution of the saccade sequence a probe dot was briefly flashed. Subjects had to localize the position of the probe dot after they had completed both saccades. I found compression of visual space only at the time of the first but not at the time of the second saccade. In the reverse-direction paradigm, subjects performed first a rightward 10° saccade followed by a leftward 10° saccade back to initial fixation. In this paradigm compression was found in similar magnitude during both saccades. Analysis of the saccade parameters did not reveal indications of saccade sequence preplanning in this paradigm. I therefore conclude that saccade planning, rather than saccade execution factors, is involved in perisaccadic compression.

  4. The GS09 double parton distribution functions

    Science.gov (United States)

    Gaunt, J. R.

    It is anticipated that hard double parton scattering (DPS) will occur frequently in the collisions of the LHC, producing interesting signals and significant backgrounds to certain single scattering processes. In order to make theoretical predictions of double scattering rates and properties, the double parton distributions (dPDFs) D_p^{j_1j_2}(x_1,x_2;Q_A,Q_B) are required. We discuss the first publicly available set of equal-scale (Q_A=Q_B) leading order dPDFs -- the GS09 dPDFs. A brief account is given describing how pQCD evolution effects and sum rule constraints (the latter derived by us) have been incorporated into this set of dPDFs. We then present a summary of a phenomenological investigation into same-sign W pair production conducted using GS09. In this, the DPS signal produced using GS09 is compared with that obtained using simple products of single PDFs multiplied by (1-x_1-x_2)^n, and the single scattering backgrounds (W+-W+-jj, di-boson and heavy flavour) are carefully calculated. It is found that the correlations in GS09 manifest themselves in non-trivial kinematic correlations between the W bosons. However, it is unlikely that these correlations will be measurable at the LHC in the near future owing to the fact that the background is significant even after cuts.

  5. 40 CFR 721.5547 - Antimony double oxide.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Antimony double oxide. 721.5547... Substances § 721.5547 Antimony double oxide. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as antimony double oxide (PMNs P-95-677 and P...

  6. Measurements of Neglected Double Stars: December 2016 Report

    Science.gov (United States)

    Carro, Joseph

    2017-07-01

    This article presents measurements of 36 neglected double stars and one double star. The stars were selected from the Washington Double Star Catalog published by the United States Naval Observatory. The photographs were taken by remote telescopes. The measurements were done by the author.

  7. Clinical and Radiographic Evaluation of Double Teeth in Primary ...

    African Journals Online (AJOL)

    2016-01-16

    Jan 16, 2016 ... KEYWORDS: Dental anomaly, double teeth, fusion, germination, primary dentition. Clinical and Radiographic Evaluation of Double ... and Pediatric Dentistry departments between. February 2009 and April 2015. ... Type III: Two fused crowns, double conical root. [Figure 1c]. • Type IV: Two fused crowns, two ...

  8. On efficiency of some ratio estimators in double sampling design ...

    African Journals Online (AJOL)

    In this paper, three sampling ratio estimators in double sampling design were proposed with the intention of finding an alternative double sampling design estimator to the conventional ratio estimator in double sampling design discussed by Cochran (1997), Okafor (2002) , Raj (1972) and Raj and Chandhok (1999).

  9. Cyclone frequency in east asia and double-cyclones

    OpenAIRE

    Umemoto, Tohru

    1982-01-01

    Japanese meteorologists call a certain type of cyclone "Futatsudama-teikiatsu" (Double-cyclone). The relationships between frequencies of extratropical cyclones and Double-cyclones were studied. Using a 2° latitude/longitude grid covering East Asia, three high frequency belts were found. Double-cyclones were classified into three types. Features of occurrence of these three types were discussed.

  10. Testing Intelligently Includes Double-Checking Wechsler IQ Scores

    Science.gov (United States)

    Kuentzel, Jeffrey G.; Hetterscheidt, Lesley A.; Barnett, Douglas

    2011-01-01

    The rigors of standardized testing make for numerous opportunities for examiner error, including simple computational mistakes in scoring. Although experts recommend that test scoring be double-checked, the extent to which independent double-checking would reduce scoring errors is not known. A double-checking procedure was established at a…

  11. Double-planting can affect gains from weed control treatments

    Science.gov (United States)

    David B. South

    2010-01-01

    Double-planting is the practice of planting two seedlings at every planting spot. When both seedlings survive, then either the less vigorous seedling is removed or each seedling is given an equal chance of being removed. Some researchers double-plant so that tree growth among experimental plots is not affected by initial differences in stocking. However, double-...

  12. Comparing and Selecting Generalized Double Ring Network Structures

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Knudsen, Thomas Phillip; Madsen, Ole Brun

    2004-01-01

    N2R(p;q) network structures were introduced recently as a generalization of double rings, and they were shown to be superior compared to double rings in terms of average distance and diameter. For a given number of nodes, there is only one double ring, but often more different N2R(p;q) structures...

  13. Rare Case of Double Looped Ansa Cervicalis Associated with its ...

    African Journals Online (AJOL)

    fibers of C1‑C3 nerves arose from this loop and ran obliquely downwards superficial to CCA and branched out to supply the infrahyoid muscles. Rare Case of Double Looped Ansa ... Keywords: Ansa cervicalis, Double loop, Nerve muscle transplant, Variation ... categorized as type 3 with the prevalence of 4% and double.

  14. Double diabetes: an emerging disease in children and young adults ...

    African Journals Online (AJOL)

    Prevention of childhood obesity by encouraging physical activities and dietary control would prevent double diabetes. Conclusion: Double diabetes is increasing in children and young adults. A high index of suspicion is required in obese children with diabetes. Keywords: Double diabetes, Emerging problem, Children, ...

  15. The double identity of doubling: Evidence for the phonology-morphology split.

    Science.gov (United States)

    Berent, Iris; Bat-El, Outi; Vaknin-Nusbaum, Vered

    2017-04-01

    Duality of patterning, is, by hypothesis, a universal design feature of language. Every language constructs words from meaningful units (morphemes), which, in turn, are comprised of meaningless phonological elements (e.g., segments, syllables). But whether the language faculty does, in fact, include a separate morphological level, distinct from the phonology, is a matter of controversy. To elucidate the role of morphology, here we ask whether morphological forms are constrained by putatively universal combinatorial principles, distinct from those applying to phonological patterns. Our research exploits the structural ambiguity of doubling. Doubling (e.g., trafraf) is open to two competing interpretations-as either a purely phonological form, or as a complex morphological structure that is systematically linked to meaning (e.g., trafraf is the diminutive of traf). Our experiments show that responses to doubling (trafraf) shift radically, depending on its level of analysis. Viewed as a meaningless phonological form, doubling is dispreferred irrespective of its kind (i.e., trafraf is as bad as traftaf, even though the latter violates a morphological constraint on contiguity). But once doubling is systematically linked to meaning (i.e., as a morphological structure), the doubling dislike shifts into a reliable preference, and an additional constraint on its contiguity arises (i.e., trafraf>traftaf). Remarkably, the dissociation between morphological and phonological doubling emerges regardless of whether morphological reduplication is abundant in participants' language (in Hebrew) or relatively rare (in English). These results suggest the existence of distinct linguistic constraints that preferentially target the morphological vs. phonological levels. We discuss various explanations for the origins of these restrictions. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Efficacy demonstration of tetanus vaccines by double antigen ELISA.

    Science.gov (United States)

    Rosskopf, U; Noeske, K; Werner, E

    2005-09-01

    This paper describes a double antigen ELISA (DAE) for rapid, specific and reliable assessment of the antitetanus immune status of horses and sheep. Compared with the indirect ELISA, the double antigen ELISA has the advantage of species-independent testing of sera. Thanks to its test design, it is more specific since the detected antibodies are forced to bind tetanus toxoid twice. In addition, it is very sensitive to tetanus antibodies, enabling the detection of low antibody titres, in range which is relevant for the assessment of the protective status (tetanus toxin neutralising antibodies). The detection limit of the DAE for tetanus antibodies is in the order of 10(-4) EU/ml. A comparison of in vitro results of individual sera with in vivo titres showed that horse sera with titres of 0.04 and 0.05 EU/ml in the DAE showed titres of > 0.05 IU and 0.034 IU/ml respectively during in vivo testing thus indicating good agreement. For tested sheep sera which were rated > 0.05 IU/ml in vivo, the corresponding titre in the DAE was 0.24 EU/ml. Clear tetanus antitoxin establishment of protective ELISA limits requires further comparative examination of sera with low titres (tetanus vaccines ad us. vet. As a consequence, the toxin neutralisation test (still being the standard method of choice for quantifying tetanus toxin neutralising antitoxin titres) could be replaced, since it requires too great a number of animals per test and involves considerable suffering for the animals. The test described here reduces the use of mice and guinea pigs within vaccine efficacy testing. In addition, it involves less exposure of the laboratory personnel to toxin.

  17. An uncommon variant of double-chambered right ventricle masquerading as double-chambered left ventricle.

    Science.gov (United States)

    Baritakis, Nikolaos; Grapsas, Nikolaos; Kotsalos, Andreas; Davlouros, Periklis

    2018-02-01

    We present a rare case of a double-chambered right ventricle masquerading as a double-chambered left ventricle, which was found incidentally on cardiac imaging in an adult female patient with atypical chest pain. The most common form of double-chambered right ventricle is characterized by compartmentalization of the right ventricle by muscular bands into 2 distinct chambers. The main features of this malformation are a pressure gradient between the 2 compartments, and the frequent (up to 90%) association with a membranous ventricular septal defect. In our case, the muscular band dividing the right ventricle was located in the inferoseptal part of the latter, creating a diminutive cavity that had no communication with the main right ventricle but communicated with the left ventricle creating the false impression of a double-chambered left ventricle. This constitutes a rare variant of double-chambered right ventricle with unknown clinical implications. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  18. Formation of Double Neutron Stars, Millisecond Pulsars and Double Black Holes

    Science.gov (United States)

    van den Heuvel, Edward P. J.

    2017-09-01

    The 1982 model for the formation of Hulse-Taylor binary radio pulsar PSR B1913+16 is described, which since has become the `standard model' for the formation of the double neutron stars, confirmed by the 2003 discovery of the double pulsar system PSR J0737-3039AB. A brief overview is given of the present status of our knowledge of the double neutron stars, of which 15 systems are presently known. The binary-recycling model for the formation of millisecond pulsars is described, as put forward independently by Alpar et al. (1982), Radhakrishnan & Srinivasan (1982) and Fabian et al. (1983). This now is the `standard model' for the formation of these objects, confirmed by the discovery in 1998 of the accreting millisecond X-ray pulsars. It is noticed that the formation process of close double black holes has analogies to that of close double neutron stars, extended to binaries with larger initial component masses, although there are also considerable differences in the physics of the binary evolution at these larger masses.

  19. Laboratory observation of multiple double layer resembling space plasma double layer

    Science.gov (United States)

    Alex, Prince; Arumugam, Saravanan; Sinha, Suraj

    2017-10-01

    Perceptible double layer consisting of more than one layers were produced in laboratory using a double discharge plasma setup. The confinement of oppositely charged particles in each layer with sharply defined luminous boarder is attributed to the self-organization scenario. This structure is generated in front of a positively biased electrode when the electron drift velocity (νd) exceeds 1.3 times the electron thermal velocity (νte) . Stable multiple double layer structures were observed only between 1.3 νte organized criticality in the emergence of turbulence. The algebraic decaying tale of the autocorrelation function and power law behavior in the power spectrum are consistent with the observation.

  20. Design and delivery of the diamond double double bend achromat project

    Energy Technology Data Exchange (ETDEWEB)

    Kay, J., E-mail: jim.kay@diamond.ac.uk; Hammond, N. P.; Thomson, A. [Diamond Light Source, Didcot, Oxfordshire, UK, OX11 0DE (United Kingdom)

    2016-07-27

    A major project is underway at Diamond Light Source to remove one of the 24 Double Bend Achromat (DBA) Storage Ring cells and replace it with a Double Double Bend Achromat (DDBA). In this way a new Insertion Device (ID) straight can be created and so ID light can be produced and delivered to a beamline previously only capable of receiving Bending Magnet (BM) radiation. This project is in support of the micro-focus Protein Crystallography (MX) beamline VMX-m which is scheduled to take users towards the end of 2017. This paper describes the Engineering Design of the DDBA project in more detail and gives the current status of the project.

  1. A randomised, double-blinded study comparing giving etoricoxib vs. placebo to female patients with fibromyalgia.

    Science.gov (United States)

    Mahagna, H; Amital, D; Amital, H

    2016-02-01

    Current therapeutic approaches to fibromyalgia syndrome (FMS) do not provide satisfactory pain control to a high percentage of patients. This unmet need constantly fuels the pursuit for new modalities for pain relief. This randomised, double-blind, controlled study assessed the efficacy and safety of adding etoricoxib vs. placebo to the current therapeutic regimen of female patients with FMS. In this double-blind, placebo-controlled study, female patients were randomised to receive either 90 mg etoricoxib once daily or placebo for 6 weeks. Several physical and mental parameters were assessed throughout the study. The primary end-point was the response to treatment, defined as ≥ 30% reduction in the average Brief Pain Inventory score. Secondary outcomes were changes in the Fibromyalgia Impact Questionnaire, SF-36 Quality of Life assessment questionnaire and Hamilton rating scales for anxiety and depression. Overall, 73 patients were recruited. Although many outcome measures improved throughout the study, no difference was recorded between the etoricoxib- and placebo-treated groups. The Brief Pain Inventory, Fibromyalgia Impact Questionnaire, The Hamilton Anxiety and Depression scores did not differ between the two groups. This is the first randomised, double-blind study assessing the effect of adding etoricoxib to pre-existing medications for female patients with FMS. Although being mildly underpowered this study clearly has shown that etoricoxib did not improve pain scores and did not lead to any beneficial mental or physical effects. © 2016 John Wiley & Sons Ltd.

  2. Comparative Analysis of Guided Modal Properties of Double-Positive and Double-Negative Metamaterial Slab Waveguides

    Directory of Open Access Journals (Sweden)

    K. Y. Kim

    2009-06-01

    Full Text Available The guided modal properties of double-positive and double-negative metamaterial slab waveguides are numerically analyzed and compared when varying the dielectric and magnetic constants. As the cutoff frequencies of both slab waveguides remained unchanged when the absolute value of the refractive index was kept invariant, this enabled an effective comparison of the respective guided modes. Thus, the guided mode dispersion characteristics of the double-positive and double-negative slab waveguides were analyzed and compared, including several higher order modes. As a result, this comparative analysis provides greater physical insights and a better understanding of the guided modal characteristics of double-negative metamaterial slab waveguides.

  3. Design studies for the Double Chooz trigger

    Energy Technology Data Exchange (ETDEWEB)

    Cucoanes, Andi Sebastian

    2009-07-24

    The main characteristic of the neutrino mixing effect is assumed to be the coupling between the flavor and the mass eigenstates. Three mixing angles ({theta}{sub 12}, {theta}{sub 23}, {theta}{sub 13}) are describing the magnitude of this effect. Still unknown, {theta}{sub 13} is considered very small, based on the measurement done by the CHOOZ experiment. A leading experiment will be Double Chooz, placed in the Ardennes region, on the same site as used by CHOOZ. The Double Chooz goal is the exploration of {proportional_to}80% from the currently allowed {theta}{sub 13} region, by searching the disappearance of reactor antineutrinos. Double Chooz will use two similar detectors, located at different distances from the reactor cores: a near one at {proportional_to}150 m where no oscillations are expected and a far one at 1.05 km distance, close to the first minimum of the survival probability function. The measurement foresees a precise comparison of neutrino rates and spectra between both detectors. The detection mechanism is based on the inverse {beta}-decay. The Double Chooz detectors have been designed to minimize the rate of random background. In a simplified view, two optically separated regions are considered. The target, filled with Gd-doped liquid scintillator, is the main antineutrino interaction volume. Surrounding the target, the inner veto region aims to tag the cosmogenic muon background which hits the detector. Both regions are viewed by photomultipliers. The Double Chooz trigger system has to be highly efficient for antineutrino events as well as for several types of background. The trigger analyzes discriminated signals from the central region and the inner veto photomultipliers. The trigger logic is fully programmable and can combine the input signals. The trigger conditions are based on the total energy released in event and on the PMT groups multiplicity. For redundancy, two independent trigger boards will be used for the central region, each of

  4. Ferroelectricity in d0 double perovskite fluoroscandates

    Science.gov (United States)

    Charles, Nenian; Rondinelli, James M.

    2015-08-01

    Ferroelectricity in strain-free and strained double perovskite fluorides, Na3ScF6 and K2NaScF6 , is investigated using first-principles density functional theory. Although the experimental room temperature crystal structures of these fluoroscandates are centrosymmetric, i.e., Na3ScF6 (P 21/n ) and K2NaScF6 (F m 3 ¯m ), lattice dynamical calculations reveal that soft polar instabilities exist in each prototypical cubic phase and that the modes harden as the tolerance factor approaches unity. Thus the double fluoroperovskites bear some similarities to A B O3 perovskite oxides; however, in contrast, these fluorides exhibit large acentric displacements of alkali metal cations (Na, K) rather than polar displacements of the transition metal cations. Biaxial strain investigations of the centrosymmetric and polar Na3ScF6 and K2NaScF6 phases reveal that the paraelectric structures are favored under compressive strain, whereas polar structures with in-plane electric polarizations (˜5 -18 μ C cm-2 ) are realized at sufficiently large tensile strains. The electric polarization and stability of the polar structures for both chemistries are found to be further enhanced and stabilized by a coexisting single octahedral tilt system. Our results suggest that polar double perovskite fluorides may be realized by suppression of octahedral rotations about more than one Cartesian axis; structures exhibiting in- or out-of-phase octahedral rotations about the c axis are more susceptible to polar symmetries.

  5. Double orifice mitral valve: A case report

    Directory of Open Access Journals (Sweden)

    Musić Ljilja

    2016-01-01

    Full Text Available Introduction. Double orifice mitrol valve (DOMV is a very rare congenital heart defect. Case report. We reported 20-year-old male referred to our center due to evaluation of his cardiologic status. He was operated on shortly after birth for a tracheoesophageal fistula. Accidentally, echocardiography examination at the age of 4 years revealed double orifice mitral valve (DOMV without the presence of mitral regurgitation, as well as mitral stenosis, with normal dimensions of all cardiac chambers. The patient was asymptomatic, even more he was a kick boxer. His physical finding was normal. Electrocardiography showed regular sinus rhythm, incomplete right bundle branch block. Transthoracic echocardiography (TTE examination revealed the normal size of the left atrial, mitral leaflets were slightly more redundant. The left and right heart chambers, aorta, tricuspid valve and pulmonary artery valve were normal. During TTE examination on a short axis view two asymmetric mitral orifices were seen as a double mitral orifice through which we registered normal flow, without regurgitation and mitral stenosis. Transesophageal echocardiography (TEE examination from the transgastric view at the level of mitral valve, showed 2 single asymmetric mitral orifices separated by fibrous tissue, mitral leaflet with a separate insertion of hordes for each orifice. Conclusion. The presented patient with DOMV is the only one recognized in our country. The case is interesting because during 16-year a follow-up period there were no functional changes despite the fact that he performed very demanded sport activities. This is very important because there is no information in the literature about that.

  6. Single-segment and double-segment INTACS for post-LASIK ectasia.

    Directory of Open Access Journals (Sweden)

    Hassan Hashemi

    2014-09-01

    Full Text Available The objective of the present study was to compare single segment and double segment INTACS rings in the treatment of post-LASIK ectasia. In this interventional study, 26 eyes with post-LASIK ectasia were assessed. Ectasia was defined as progressive myopia regardless of astigmatism, along with topographic evidence of inferior steepening of the cornea after LASIK. We excluded those with a history of intraocular surgery, certain eye conditions, and immune disorders, as well as monocular, pregnant and lactating patients. A total of 11 eyes had double ring and 15 eyes had single ring implantation. Visual and refractive outcomes were compared with preoperative values based on the number of implanted INTACS rings. Pre and postoperative spherical equivalent were -3.92 and -2.29 diopter (P=0.007. The spherical equivalent decreased by 1 ± 3.2 diopter in the single-segment group and 2.56 ± 1.58 diopter in the double-segment group (P=0.165. Mean preoperative astigmatism was 2.38 ± 1.93 diopter which decreased to 2.14 ± 1.1 diopter after surgery (P=0.508; 0.87 ± 1.98 diopter decrease in the single-segment group and 0.67 ± 1.2 diopter increase in the double-segment group (P=0.025. Nineteen patients (75% gained one or two lines, and only three, who were all in the double-segment group, lost one or two lines of best corrected visual acuity. The spherical equivalent and vision significantly decreased in all patients. In these post-LASIK ectasia patients, the spherical equivalent was corrected better with two segments compared to single segment implantation; nonetheless, the level of astigmatism in the single-segment group was significantly better than that in the double-segment group.

  7. Double exchange model for magnetic hexaborides.

    Science.gov (United States)

    Pereira, Vitor M; Lopes dos Santos, J M B; Castro, Eduardo V; Neto, A H Castro

    2004-10-01

    A microscopic theory for rare-earth ferromagnetic hexaborides, such as Eu1-xCaxB6, is proposed on the basis of the double-exchange Hamiltonian. In these systems, the reduced carrier concentrations place the Fermi level near the mobility edge, introduced in the spectral density by the disordered spin background. We show that the transport properties such as the Hall effect, magnetoresistance, frequency dependent conductivity, and dc resistivity can be quantitatively described within the model. We also make specific predictions for the behavior of the Curie temperature T(C) as a function of the plasma frequency omega(p).

  8. Routing in double layered satellite network

    Science.gov (United States)

    Fan, Xiaofeng; Fei, Gao

    2009-07-01

    With the fast development of aviation technology and network, satellite communication systems are not limited to a signal satellite any more, they are now oriented to network. Double LEO/MEO network can separate network manage from traffic in physical layer in order to manage total network and operate central routing. At last, aiming at the problem of the frequency link switch, we give a new routing protocol (OSPF_SAT) based on OSPF routing protocol. The optimized strategy routing algorithm and is applied to the model, with the result of getting less link switch ratio.

  9. Double maxima of 11-year solar cycles

    Science.gov (United States)

    Krivodubskij, V. N.

    2015-10-01

    The explanation of the observed phenomenon of double peaks of the 11 year sunspot cycles is proposed. The scenario involves five processes of reconstruction of magnetism in the solar convective zone (SCZ): ω effect, magnetic buoyancy, macroscopic turbulent diamagnetism, rotary \\downtriangle ρ effect and meridional circulation. It was established that the reconstruction of magnetism in high-latitude and equatorial domains of the SCZ occurs in different modes. Two time-shifted waves of the toroidal field to the solar surface play a key role in the proposed mechanism in the equatorial domain.

  10. Elderly donors double kidney transplantation (DKT)

    OpenAIRE

    Méndez-Chacón, Pedro; Facultad de Medicina, UNMSM. Lima, Perú; Servicio Nefrología. Servicio de Patología. Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú; Vidalón, Armando; Facultad de Medicina, UNMSM. Lima, Perú; Servicio Nefrología. Servicio de Patología. Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú; Medina, Mario; Servicio Nefrología. Servicio de Patología. Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú; Camacho, Miguel; Servicio Nefrología. Servicio de Patología. Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú; Somocurcio, José; Servicio Nefrología. Servicio de Patología. Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú

    2013-01-01

    Objective: To use both kidneys of an elderly donor in the same receptor and remark the importance of kidney histology as selector method. Materials and Methods: We evaluate the selection and surveillance of 11 patients who received double kidney of cadaver elderly donors. The ten donors’ mean serum creatinine was 1,3 mg/dL, and the mean age was 63 years old (range 56 to 73 years), the receptor’s mean age 53 years. Both kidneys were examined by frozen wedge biopsy. Quantification of damaged ti...

  11. Double issue of the Bulletin for Ascension

    CERN Multimedia

    Publications Section (ETT)

    2004-01-01

    Because Thursday 20 May and Friday 21 May are official holidays, there will be a double issue of the Bulletin (No. 21-22/2004) covering the weeks of 17 and 24 May. The deadline for texts to appear in this issue will be midday on Tuesday, 11 May, both for articles submitted to the Publications Section and for those of the Staff Association. Articles for the following issue of the Bulletin (No. 23/2004), which will cover the week of 31 May, should be submitted by midday on Tuesday 25 May at the latest.

  12. Structures of Thermal Double Donors in Silicon

    OpenAIRE

    Pesola, M.; Joo Lee, Young; von Boehm, J.; Kaukonen, M.; Nieminen, Risto M.

    2000-01-01

    Accurate total-energy calculations are used to study the structures and formation energies of oxygen chains as models for thermal double donors (TDD's) in Si. We find that the first three TDD's (TDD0–TDD2) consist of one four-member ring, with one or two adjacent interstitial O atoms. These metastable TDD's form bistable negative-U systems with the corresponding stable, electrically inactive staggered structures. The TDD3-TDD7 structures are found to consist of four-member rings with adjacent...

  13. The high sensitivity double beta spectrometer TGV

    Science.gov (United States)

    Briancon, Ch.; Brudanin, V. B.; Egorov, V. G.; Janout, Z.; Koníček, J.; Kovalík, A.; Kovalenko, V. E.; Kubašta, J.; Pospíšil, S.; Revenko, A. V.; Rukhadze, N. I.; Salamatin, A. V.; Sandukovsky, V. G.; Štekl, I.; Timkin, V. V.; Tsupko-Sitnikov, V. V.; Vorobel, V.; Vylov, Ts.

    1996-02-01

    A high sensitivity double beta spectrometer TGV (Telescope Germanium Vertical) has been developed. It is based on 16 HPGe detectors of volume 1200 × 6 mm 3 each in the same cryostat. The TGV spectrometer was proposed for the study of ultrarare nuclear processes (e.g. 2νββ, 0νββ, 2νEC/EC). Details of the TGV spectrometer construction are described, the principles of background suppression, the results of Monte Carlo simulations and the results of test background measurements (in Dubna and Modane underground laboratory) are provided.

  14. NGC 4340: Double Bar + Fossil Nuclear Ring

    OpenAIRE

    Erwin, P.; Beltran, J. C. Vega; Beckman, J. E.

    2000-01-01

    NGC 4340 is a double-barred SB0 galaxy in the Virgo cluster (Wozniak et al. 1995). Here, we present evidence that this galaxy also posseses a luminous stellar nuclear ring of relatively old stars with little or no gas. The ring lies just outside the inner bar, at the probable inner inner Lindblad resonance (IILR) of the outer bar. Careful inspection of the isophotes and unsharp masks shows that the two bars are slightly misaligned, which suggests they may be independently rotating.

  15. Minimally doubled fermions at one loop

    Science.gov (United States)

    Capitani, Stefano; Weber, Johannes; Wittig, Hartmut

    2009-10-01

    Minimally doubled fermions have been proposed as a cost-effective realization of chiral symmetry at non-zero lattice spacing. Using lattice perturbation theory at one loop, we study their renormalization properties. Specifically, we investigate the consequences of the breaking of hyper-cubic symmetry, which is a typical feature of this class of fermionic discretizations. Our results for the quark self-energy indicate that the four-momentum undergoes a renormalization which is linearly divergent. We also compute renormalization factors for quark bilinears, construct the conserved vector and axial-vector currents and verify that at one loop the renormalization factors of the latter are equal to one.

  16. Triple Pelvic Osteotomy and Double Pelvic Osteotomy.

    Science.gov (United States)

    Guevara, Francisco; Franklin, Samuel P

    2017-07-01

    Triple and double pelvic osteotomy (TPO, DPO) are performed with the goal of increasing acetabular ventro-version, increasing femoral head coverage, and decreasing femoral head subluxation. Since the first descriptions of TPO, there have been modifications in technique, most notably omission of the ischial osteotomy for DPO, and improvements in the implants, including availability of locking TPO/DPO bone plates. Associated complication rates seem to have declined accordingly. The most salient questions regarding these procedures remain what selection criteria should be used to identify candidates and whether halting or preventing osteoarthritis is necessary to consider these surgeries clinically beneficial. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Jonckheere Double Star Photometry - Part VII: Aquarius

    Science.gov (United States)

    Knapp, Wilfried R. A.

    2017-10-01

    If any double star discoverer is in urgent need of photometry then it is Jonckheere. There are over 3000 Jonckheere objects listed in the WDS catalog and a good part of them with magnitudes obviously far too bright. This report covers the Jonckheere objects in the constellation Aquarius. One image per object was taken with V-filter to allow for visual magnitude measurement by differential pho-tometry. All objects were additionally checked for common proper motion by comparing 2MASS to GAIA DR1 positions and a rather surprisingly large part of the objects qualify indeed as potential CPM pairs. For a few objects also WDS position errors were found.

  18. ProTec Tear-Offs: A Preliminary Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Peeler, D

    2005-09-01

    The Savannah River National Laboratory (SRNL) has conducted a series of ''scoping'' tests (referred to as Phase 1) to assess the potential use of a Mylar{reg_sign} tear-off system as a primary or secondary protective barrier to minimize acid etching (''frosting''), accidental scratching, and/or radiation damage for shielded cells windows. Conceptually, thin, multi-layered sheets of Mylar (referred to as a ''tear-off'' system) could be directly applied to the Lexan{reg_sign} sheet or glovebox/hood sash window to serve as a secondary (or primary) barrier. Upon degradation of visual clarity due to accidental scratching, spills/splatters, and/or radiation damage, the outer layer (or sheet) of Mylar could be removed ''refreshing'' or restoring the view. Due to the multi-layer aspect, the remaining Mylar layers would provide continued protection for the window from potential reoccurrences (which could be immediate or after some extended time period). Although the concept of using a tear-off system as a protective barrier was conceptually enticing, potential technical issues were identified and addressed as part of this Phase 1 feasibility study. These included resistance to: (1) acid(s) (concentrated (28.9 M) HF, concentrated (15.9M) HNO{sub 3}, 6M HCl, and 0.6M H{sub 3}BO{sub 3}), (2) base (a simulated sludge with pH of 12.9), (3) gamma radiation (cumulative dose of {approx}200,000 rad), and (4) scratch resistance (simulating accidental scratching with the manipulators). Not only can these four factors play a significant role in determining the visual clarity of the integrated system, they can also contribute to the mechanical integrity issues which could dictate the ability to remove the outer layer when visual clarity has degraded. The results of the Phase 1 study clearly indicate that the Mylar tear-off concept (as a primary or secondary protective barrier) is a potential technical

  19. Designing of Timber Bolt Connection Subjected To Double Unequal Shears

    Science.gov (United States)

    Musilek, Josef; Plachy, Jan

    2017-10-01

    The paper deals with load-carrying capacity of bolted connections subjected to unequal double shear with thin plates as outer members and inner timber member. This type of connection is usually widespread and in building support structures made of wood is commonly used. This may occur for example in skeletal structures which contain structural elements based on wood, but also for smaller wooden buildings. Specifically, this type of connection can be found in ceiling structures in the joint joists and beams. If one joist greater margin than the second, bringing the load on the side of the joists of a larger span greater loads than on the side with a smaller span joist. Structure engineer, who is designing such a connection, must use for the design of the connection design procedures and formulas from which he or she calculates the design resistance in order to carry out further assessment of the reliability of the connection in the ultimate limit state. The load-carrying capacity of this connections type can be calculated at present according to Johansen’s equations, which are also contained in present European standard for the design timber structures -Eurocode 5. These Johansen’s equations assume that the loads which act on the outer plates are equal. For this reason, the structure engineer is often forced to use formulas intended for the timber bolt connection subjected to double equal shear and he or she must find ways how to use them although the formulas are not suitable. This paper deals with the case, when the loads acting on the outer plates are unequal.

  20. DOuble LOngitudinal Megapreputium Incision TEchnique: the DOLOMITE.

    Science.gov (United States)

    Callewaert, Piet R H; Rahnama'i, Mohammad S; Guimarães, Maia N C; Vrijens, Daisy M J; Van Kerrebroeck, Philip E V A

    2014-05-01

    To present a straightforward, reproducible technique with the basic principle of preserving all available outer penile shaft skin and using this to cover the dorsal side of the penis. The DOuble LOngitudinal Megapreputium Incision TEchnique is presented in a step-by-step fashion. Six consecutive patients with a mean age of 13.3 months (range, 7-25) underwent this reconstruction between 2006 and 2011. The technique starts with 2 longitudinal incisions, the first on the ventral side, and the second on the dorsal side of the penis. After hinging the penile skin to the dorsal side, redundant inner preputial tissue is resected using diagonal incisions. Dartos is spared. A comparison with previously reported techniques and a concise review of existing literature are provided. The final cosmetic results, after an initial period of edematous swelling of the ventral aspect of the penis, were good in all patients. The bilateral diagonal scars on the penile shaft became inconspicuous over time. Voiding normalized. No complications occurred. The DOuble LOngitudinal Megapreputium Incision TEchnique provides a straightforward and reproducible surgical correction for congenital megaprepuce. Copyright © 2014 Elsevier Inc. All rights reserved.