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Sample records for assay project phase

  1. Final Report Nucleic Acid System - Hybrid PCR and Multiplex Assay Project Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Koopman, R P; Langlois, R G; Nasarabadi, S; Benett, W J; Colston, B W; Johnson, D C; Brown, S B; Stratton, P L; Milanovich, F P

    2002-04-17

    This report covers phase 2 (year 2) of the Nucleic Acid System--Hybrid PCR and Multiplex Assay project. The objective of the project is to reduce to practice the detection and identification of biological warfare pathogens by the nucleic acid recognition technique of PCR (polymerase chain reaction) in a multiplex mode using flow cytometry. The Hybrid instrument consists of a flow-through PCR module capable of handling a multiplexed PCR assay, a hybridizing module capable of hybridizing multiplexed PCR amplicons and beads, and a flow cytometer module for bead-based identification, all controlled by a single computer. Multiplex immunoassay using bead-based Luminex flow cytometry is available, allowing rapid screening for many agents. PCR is highly specific and complements and verifies immunoassay. It can also be multiplexed and detection provided using the bead-based Luminex flow cytometer. This approach allows full access to the speed and 100-fold multiplex capability of flow cytometry for rapid screening as well as the accuracy and specificity of PCR. This project has two principal activities: (1) Design, build and test a prototype hybrid PCR/flow cytometer with the basic capabilities for rapid, broad spectrum detection and identification, and (2) Develop and evaluate multiplex flow analysis assay protocols and reagents for the simultaneous detection of PCR products. This project requires not only building operationally functional instrumentation but also developing the chemical assays for detection of priority pathogens. This involves development and evaluation of multiplex flow analysis assay protocols and reagents for the simultaneous detection of PCR products.

  2. Automated UF6 Cylinder Enrichment Assay: Status of the Hybrid Enrichment Verification Array (HEVA) Project: POTAS Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, David V.; Orton, Christopher R.; Mace, Emily K.; McDonald, Benjamin S.; Kulisek, Jonathan A.; Smith, Leon E.

    2012-06-01

    Pacific Northwest National Laboratory (PNNL) intends to automate the UF6 cylinder nondestructive assay (NDA) verification currently performed by the International Atomic Energy Agency (IAEA) at enrichment plants. PNNL is proposing the installation of a portal monitor at a key measurement point to positively identify each cylinder, measure its mass and enrichment, store the data along with operator inputs in a secure database, and maintain continuity of knowledge on measured cylinders until inspector arrival. This report summarizes the status of the research and development of an enrichment assay methodology supporting the cylinder verification concept. The enrichment assay approach exploits a hybrid of two passively-detected ionizing-radiation signatures: the traditional enrichment meter signature (186-keV photon peak area) and a non-traditional signature, manifested in the high-energy (3 to 8 MeV) gamma-ray continuum, generated by neutron emission from UF6. PNNL has designed, fabricated, and field-tested several prototype assay sensor packages in an effort to demonstrate proof-of-principle for the hybrid assay approach, quantify the expected assay precision for various categories of cylinder contents, and assess the potential for unsupervised deployment of the technology in a portal-monitor form factor. We refer to recent sensor-package prototypes as the Hybrid Enrichment Verification Array (HEVA). The report provides an overview of the assay signatures and summarizes the results of several HEVA field measurement campaigns on populations of Type 30B UF6 cylinders containing low-enriched uranium (LEU), natural uranium (NU), and depleted uranium (DU). Approaches to performance optimization of the assay technique via radiation transport modeling are briefly described, as are spectroscopic and data-analysis algorithms.

  3. Nondestructive waste assay capability evaluation project

    International Nuclear Information System (INIS)

    For most containerized waste forms, the most common and efficient means to determine the TRU material quantity is the use of nondestructive assay (NDA) techniques. Requirements and quality assurance objectives (QAOs) for NDA techniques employed to characterize TRU waste destined for the Waste Isolation Pilot Plant are delineated in the National TRU Program Transuranic Waste Characterization Quality Assurance Program Plan (QAPP). These QAOs represent minimum performance requirements consisting of allowable measurement parameter ranges such as bias and precision for which compliance must be demonstrated in accordance with the prescriptions of the QAPP. To establish actual capabilities of existing nondestructive waste assay systems relative to the requirements of the QAPP, a mechanism is required to acquire performance data for waste types typical of the DOE inventory and to objectively evaluate such data. In accordance with this need, the DOE mixed waste focus area operating in conjunction with the characterization monitoring and sensor technology crosscut area program has instituted an assay capability evaluation project (CEP). The project is focused on mobile NDA technologies but is applicable to most permanently installed systems operating the same NDA technology. The evaluation project is currently being conducted at the Idaho National Engineering and Environmental Laboratory (INEEL) Radioactive Waste Management Complex (RWMC) using actual Rocky Flats Plant-generated waste forms currently in storage and appropriate matrix/radioactive material surrogates. Six mobile waste assay system technologies are participating in the CEP: (1) segmented gamma scanner; (2) active and passive computed tomography; (3) high-efficiency neutron counter; (4) IQ3-gamma assay system; (5) tomographic gamma scanner; and (6) an imaging passive/active neutron system

  4. Project Risk Management Phases

    OpenAIRE

    Claudiu-George BOCEAN

    2008-01-01

    Risk management is the human activity which integrates recognition of risk, risk assessment, developing strategies to manage it, and mitigation of risk using managerial resources. Notwithstanding the domain of activities where they are conducted, projects often entail risks, and risk management has been widely recognized as a success factor in project management. Following a concept clarification on project risk management, this paper presents a generic list steps in the risk management proce...

  5. Using projections for phase retrieval

    Science.gov (United States)

    Cahill, Jameson; Casazza, Peter G.; Peterson, Jesse; Woodland, Lindsey M.

    2013-09-01

    The mathematical study of phase retrieval was started in 2006 in a landmark paper of Balan, Casazza and Edidin. This quickly became a heavily studied topic with implications for many areas of research in both applied mathematics and engineering. Recently there have been developments in a new area of study pertaining to phase retrieval given by projections. We give an extensive overview of the papers regarding projection phase retrieval.

  6. Inception phase of construction project

    OpenAIRE

    Zahirović, Bojan

    2015-01-01

    The thesis describes the construction project in terms of investment. The documentation is collected for the design and concept phase. In addition to the aforementioned investment documentation there is the environmental and spatial documentation and implementation path for the construction project start. Construction project coordination is interlinked with management, i.e. connection of two disciplines – economics and construction – into construction management, which is credite...

  7. Solid phase group specific absorbants in assays for glycoproteins

    International Nuclear Information System (INIS)

    The focus of this paper is on several technical advances in the assays for glycoprotein hormones and enzymes that have been achieved by use of the solid phase carbohydrate specific adsorbant concanavalin-A. Puriffication of glycoprotein radioligand after labelling by the chloramine-T method is readily accomplished using a small column of agarose bound concanavalin-A which separates glycoprotein radioligand from radioiodide and radiolabelled unadsorbed contaminants. After concanavalin-A column chromatography, radiolabelled glycoprotein hormone preparations exhibited improved binding to antibodies and tissue receptors. To increase the effective sensitivity of radioimmunoassays for glycoproteins, agarose bound concanavalin-A is used to extract and concentrate the glycoproteins from various biologic samples. For example, the effective sensitivity for the detection of human thyrotropin in serum was improved approximately 5 fold by using concanavalin-A concentrates of 1.5 ml of serum. Partial purification of the glycoprotein dopamine-β-hydroxylase from serum using agarose bound concanavalin-A resulted in separation of the serum factors that interfere with the measurement of enzyme activity. We conclude that in assays for glycoproteins, concanavalin-A is useful for purification of radioligand, for preparation of concentrates of glycoproteins from biologic samples, and for separation of glycoproteins from various interfering factors contained in biologic samples prior to radioligand or radioenzyme assay. (orig.)

  8. PROJECT GOVERNANCE – PHASES AND LIFE CYCLE

    Directory of Open Access Journals (Sweden)

    Robbert Titus DEENEN

    2007-01-01

    Full Text Available When talking about projects, the barrier is clear: successful and failed. Some fail due to different reasons, but lack of good project and risk management played a large part. Others succeed largely because of the rigorous and disciplined application of good project practices. But both groups illustrate many points that underline and demonstrate important concepts applicable to current projects. Systematic application of good methods leads to successful outcomes in projects of all types. All projects are fundamentally dependent on people, and human beings are not very different today than we were hundreds, or even thousands, of years ago. This paper uncovers main elements in projects area such as the concepts and governance of projects, with an underline of the main characteristics and the projects phases and life cycle that erase the uncertainty that joins all the projects built at any time.

  9. Diss-phase II Project

    Energy Technology Data Exchange (ETDEWEB)

    Zarza, E.; Morales, A.; Rojas, E.; Valenzueala, L.; Leon, J.; Weyers, D.; Eickhoff, M.; Eck, M.; Hennecke, K.; Rheinlander, J.; Langenkamp, J.; Gonzalez, S.

    2001-07-01

    The DISS project is a complete R+T program aimed at developing a new generation of Solar Thermal Power Plants with parabolic trough collectors. This R+D program is based on three items. 1. Development and implementation of improved components for parabolic trough collectors. 2. development of the Direct Steam Generation (DSG) process to eliminate the oil used at the existing solar thermal plants as a heat carrier from the solar field to the power block. The DSG process will increase the overall system efficiency while reducing the investment costs. 3. Optimisation of the overall plant design to achieve a better coupling between the solar field and the power block, and improvement of the Q and M procedures.

  10. Yakima Basin Fish Passage Project, Phase 2

    International Nuclear Information System (INIS)

    Implementation of the Yakima Basin Fish Passage Project -- Phase 2 would significantly improve the production of anadromous fish in the Yakima River system. The project would provide offsite mitigation and help to compensate for lower Columbia River hydroelectric fishery losses. The Phase 2 screens would allow greater numbers of juvenile anadromous fish to survive. As a consequence, there would be higher returns of adult salmon and steelhead to the Yakima River. The proposed action would play an integral part in the overall Yakima River anadromous fish enhancement program (fish passage improvement, habitat enhancement, hatchery production increases, and harvest management). These would be environmental benefits associated with implementation of the Fish Passage and Protective Facilities Phase 2 Project. Based on the evaluation presented in this assessment, there would be no significant adverse environmental impacts if the proposed action was carried forward. No significant adverse environmental effects have been identified from construction and operation of the Yakima Phase 2 fish passage project. Proper design and implementation of the project will ensure no adverse effects will occur. Based on the information in this environmental analysis, BPA's and Reclamation's proposal to construct these facilities does not constitute a major Federal action that could significantly affect the quality of the human environment. 8 refs., 4 figs., 6 tabs

  11. Laser projection using generalized phase contrast

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Palima, Darwin; Rodrigo, Peter John;

    2007-01-01

    We demonstrate experimental laser projection of a gray-level photographic image with 74% light efficiency using the generalized phase contrast (GPC) method. In contrast with a previously proposed technique [Alonzo et al., New J. Phys. 9, 132 (2007)], a new approach to image construction via GPC...

  12. Development of a solid-phase assay for measurement of proteolytic enzyme activity

    International Nuclear Information System (INIS)

    A solid-phase, plate assay was developed for the measurement of proteolytic enzyme activity. In this assay procedure, radiolabeled substrates were dried onto the surface of microtiter wells. Following drying, the wells were washed two times with saline to remove the nonadherent substrate. When proteolytic enzymes were added to the wells, protein hydrolysis occurred, releasing radioactivity into the supernatant fluid. The amount of protein hydrolysis that occurred was reflected by the amount of radioactivity in the supernatant fluid. When 125I-hemoglobin was used as the substrate, it was as susceptible to hydrolysis by trypsin in the solid-phase assay as it was in solution in a standard assay procedure. Protease activity from a variety of sources (including from viable cells as well as from extracellular sources) were also able to hydrolyze the hemoglobin on the plate. 125I-Labeled serum albumen, fibrinogen, and rat pulmonary basement membrane were also susceptible to hydrolysis by trypsin in the solid phase. When [14C]elastin was dried onto the plate, it behaved in a similar manner to elastin in solution. It was resistant to hydrolysis by nonspecific proteases such as trypsin and chymotrypsin but was highly susceptible to hydrolysis by elastase. The solid-phase plate assay has several features which recommended it for routine use. It is as sensitive as standard tube assays (and much more sensitive than routinely used colormetric assays). It is quick and convenient; there are no precipitation, centrifugation, or filtration steps. In addition, very small volumes of radioactive wastes are generated. Another advantage of the solid-phase plate assay is the resistance of the dried substrates to spontaneous breakdown and to microbial contamination. Finally, this assay is suitable for use with viable cells as well as for extracellular proteases

  13. Nondestructive assay instrumentation for a Savannah River Plant upgrade project

    International Nuclear Information System (INIS)

    We have designed and are developing three different computer-based spectrometer systems. Two will measure the concentration of Pu solutions by gamma-ray and by stimulated x-ray fluorescence emissions of solid samples in closed containers. All systems are coupled to remote terminals and bar code readers, and also to mini-computer based multichannel analyzers, which in turn are linked to another computer to provide a state-of-the-art nondestructive assay capability. Installation at the Savannah River Plant is planned in late 1985. 7 references

  14. Managing project complexity: A study into adapting early project phases to improve project performance in large engineering projects

    OpenAIRE

    Bosch-Rekveldt, M.G.C.

    2011-01-01

    Engineering projects become increasingly more complex and project complexity is assumed to be one of the causes for projects being delivered late and over budget. However, what this project complexity actually comprised of was unclear. To improve the overall project performance, this study focuses on identifying the potential causes of complexity in projects. Moreover, it is investigated how the early project phase could be adapted to the complexity of the project. The research is performed w...

  15. IDC Reengineering Phase 2 Project Scope.

    Energy Technology Data Exchange (ETDEWEB)

    Harris, James M.

    2015-02-01

    This report provides a brief description of the scope of the IDC Reengineering Phase 2 project. It describes the goals and objectives of reengineering, the system definition, and the technical scope of the system. REVISIONS Version Date Author/Team Revision Description Authorized by 1.0 9/25/2014 SNL IDC Reengineering Team Unlimited Release for I2 M. Harris 1.1 28/01/2015 IDC Reengineering Team Align with previous IDC scope document E. Tomuta

  16. Development of simple immunoradiometric assays using avidin coupled to polystyrene beads as a common solid phase

    International Nuclear Information System (INIS)

    In this paper, we describe the preparation and application of avidin coupled polystyrene beads as a common solid phase for use in immunoradiometric assays (IRMAs). The assay system is based on two matched commercial monoclonal antibodies, of which, the capture antibody is biotinylated using biotinamidocaproate N-hydroxysuccinimide ester and the detection antibody is radiolabeled with 125I by conventional Chloramine-T method. Avidin was immobilized on the polystyrene beads through a primary coat of bovine serum albumin using glutaraldhyde activation method. Various factors, such as concentration of reagents, incubation time, etc. were optimised to obtain a simple assay protocol consisting of only two pipetting steps, namely, that of a mixture of the two labelled antibodies (radiolabelled and biotinylated) and of the standard or sample. The advantage of the Avidin-Biotin system is the improved sensitivity, economy of antibody and the possibility to use a common solid phase in assays for different analytes. Using the polystyrene beads along with the novel decanting device, it has been possible to achieve the convenience of the 'coated-tube' technology without the expensive automation necessary for large scale preparation of antibody coated tubes. This protocol has been successfully applied to Prolactin, LH and FSH assays. The sensitivity of the Prolactin assay is 8μIU/mL (0.3 ng/mL), that of the FSH assay is 1mIU/mL and that of the LH assay is 0.9 mIU/mL. The intra-assay and inter-assay variations were <10%. Shelf life of the avidin coupled beads was found to be about 8 months and that of the biotin labelled antibodies up to 18 months. (author)

  17. Reversed-phase high-performance liquid chromatographic method for the assay of oxytetracycline.

    Science.gov (United States)

    Barnes, W N; Ray, A; Bates, L J

    1985-10-25

    The British Pharmacopoeia monograph for oxytetracycline calcium describes an high-performance liquid chromatographic (HPLC) assay which requires packing of the column by the analyst. Presented in this report is an HPLC method for the assay of oxytetracycline which employs a commercially available reversed-phase column and a solvent system which gives improved separation of the antibiotic from common impurities. Results obtained using this method for both bulk and dosage forms of oxytetracycline are in accord with the results of the microbiological assays. PMID:4086631

  18. Automatic on-chip RNA–DNA hybridization assay with integrated phase change microvalves

    International Nuclear Information System (INIS)

    An RNA–DNA hybridization assay microfluidic chip integrated with electrothermally actuated phase change microvalves for detecting pathogenic bacteria is presented in this paper. In order to realize the sequential loading and washing processes required in such an assay, gravity-based pressure-driven flow and phase-change microvalves were used in the microfluidic chip. Paraffin wax was used as the phase change material in the valves and thin film heaters were used to electrothermally actuate microvalves. Light absorption measured by a photodetector to determine the concentrations of the samples. The automatic control of the complete assay was implemented by a self-coded LabVIEW program. To examine the performance of this chip, Salmonella was used as a sample pathogen. Significantly, reduction in reagent/sample consumption (up to 20 folds) was achieved by this on-chip assay, compared with using the commercial test kit following the same protocol in conventional labs. The experimental results show that the quantitative detection can be obtained in approximately 26 min, and the detection limit is as low as 103 CFU ml−1. This RNA–DNA hybridization assay microfluidic chip shows an excellent potential in the development of a portable device for point-of-testing applications. (paper)

  19. Creation of reversed phase high-performance liquid chromatographic technique to assay platelet-activating factor

    Institute of Scientific and Technical Information of China (English)

    杨云梅; 曹红翠; 徐哲荣; 陈晓明

    2004-01-01

    Objective: To establish a new assay for platelet-activating factor (PAF), to compare it with bio-assay; and to discuss its significance in some elderly people diseases such as cerebral infarction and coronary heart disease. Methods: To measure PAF levels in 100 controls, 23 elderly patients with cerebral infarction and 65 cases with coronary heart disease by reversed phase high-performance liquid chromatographic technique (rHPLC). Results:rHPLC is more convenient, sensitive,specific, and less confusing, compared with bio-assay. The level of plasma PAF in patients with cerebral infarction was higher than that in the controls (P<0.01), and in patients with coronary heart disease. Conclusion: Detection of PAF with rHPLC is more reliable and more accurate. The new assay has important significance in PAF research.

  20. Creation of reversed phase high-performance liquid chromatographic technique to assay platelet-activating factor

    Institute of Scientific and Technical Information of China (English)

    杨云梅; 曹红翠; 徐哲荣; 陈晓明

    2004-01-01

    Objective: To establish a new assay for platelet-activating factor (PAF), to compare it with bio-assay; and to discuss its significance in some elderly people diseases such as cerebral infarction and coronary heart disease. Methods: To measure PAF levels in 100 controls, 23 elderly patients with cerebral infarction and 65 cases with coronary heart disease by reversed phase high-performance liquid chromatographic technique (rHPLC). Results: rHPLC is more convenient, sensitive, specific, and less confusing, compared with bio-assay. The level of plasma PAF in patients with cerebral infarction was higher than that in the controls (P<0.01), and in patients with coronary heart disease. Conclusion: Detection of PAF with rHPLC is more reliable and more accurate. The new assay has important significance in PAF research.

  1. Project Phase Dependent Configuration of Project Management Information Systems

    OpenAIRE

    Bērziša, S; Grabis, J.

    2012-01-01

    Project management information systems ensure the collection and display of project information. The project information changes depend upon the project environment. According to project environment and requirements, the configuration of project management information system is ensured by means of an approach to configuration of project management information systems. However, topicality of information and access to it change during the project life cycle depending upo...

  2. 13 CFR 305.9 - Project phasing and Investment disbursement.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Project phasing and Investment... § 305.9 Project phasing and Investment disbursement. (a) EDA may authorize in advance the award of...: (1) Valid reasons justifying why the Project must be phased; (2) Description of the specific...

  3. Indirect solid-phase immunosorbent assay for detection of arenavirus antigens and antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, A.P.; Rezapkin, G.V.; Dzagurova, T.K.; Tkachenko, E.A. (Institute of Poliomyelitis anU Viral Encephalities of the U.S.S.R. Academy of Medical Sciences, Moscow)

    1984-05-01

    Indirect enzyme-linked immunosorbent assay (ELISA) and solid phase radioimmunoassay (SPRIA) using either enti-human or anti-mouse IgG labelled with horseradish peroxidase and /sup 125/I, respectively, were developed for the detection of Junin, Machupo, Tacaribe, Amapari, Tamiami, Lassa and LCM arenaviruses. Both methods allow high sensitivity detection of arenavirus antigens and antibodies.

  4. Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals

    DEFF Research Database (Denmark)

    Bertelsen, M. F.; Kjelgaard-Hansen, M.; Grøndahl, C.;

    2009-01-01

    The serum concentration of acute phase proteins (APPs) increases dramatically in response to inflammation and tissue injury. APPs are clinically useful in a range of domesticated mammals; however, knowledge is limited in nondomesticated mammals. The detective ability of two assays for each of thr...

  5. Vapor Compressor Driven Hybrid Two-Phase Loop Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project will demonstrate a vapor compressor driven hybrid two-phase loop technology. The hybrid two-phase loop...

  6. Solid-phase peptide quantitation assay using labeled monoclonal antibody and glutaraldehyde fixation

    International Nuclear Information System (INIS)

    A solid-phase radioimmunoassay utilizing iodinated peptide-specific monoclonal antibody as a detection system instead of labeled peptide has been developed. Regional specific monoclonal antibodies to either gastrin-releasing peptide or gastrin were used as models to validate the general application of our modified assay. Conditions for radioactive labeling of the monoclonal antibody were determined to minimize oxidant damage, which compromises the sensitivity of other reported peptide quantitation assays. Pretreatment of 96-well polyvinyl chloride test plates with a 5% glutaraldehyde solution resulted in consistent retention of sufficient target peptide on the solid-phase matrix to allow precise quantitation. This quantitative method is completed within 1 h of peptide solid phasing. Pretreatment of assay plates with glutaraldehyde increased binding of target peptide and maximized antibody binding by optimizing antigen presentation. The hypothesis that glutaraldehyde affects both peptide binding to the plate and orientation of the peptide was confirmed by analysis of several peptide analogs. These studies indicate that peptide binding was mediated through a free amino group leaving the carboxy-terminal portion of the target peptide accessible for antibody binding. It was observed that the length of the peptide also affects the amount of monoclonal antibody that will bind. Under the optimal conditions, results from quantitation of gastrin-releasing peptide in relevant samples agree well with those from previously reported techniques. Thus, we report here a modified microplate assay which may be generally applied for the rapid and sensitive quantitation of peptide hormones

  7. Sequential, solid-phase assay for biotin in physiologic fluids that correlates with expected biotin status

    International Nuclear Information System (INIS)

    Interest in accurate measurement of biotin concentrations in plasma and urine has been stimulated by recent advances in the understanding of biotin-responsive inborn errors of metabolism and by several reports describing acquired biotin deficiency during parenteral alimentation. This paper presents a biotin assay utilizing radiolabeled avidin in a sequential, solid-phase method; the assay has increased sensitivity compared to previous methods (greater than or equal to 10 fmol/tube), correlates with expected trends in biotin concentrations in blood and urine in a rat model of biotin deficiency, and can utilize commercially available radiolabeled avidin

  8. Capture-S, a nontreponemal solid-phase erythrocyte adherence assay for serological detection of syphilis.

    OpenAIRE

    Stone, D L; Moheng, M C; Rolih, S; Sinor, L T

    1997-01-01

    A solid-phase erythrocyte adherence assay has been developed for the serological detection of reagin antibodies in syphilis. Capture-S (Immucor, Inc., Norcross, Ga.) is a nontreponemal, qualitative screening test for the detection of immunoglobulin G (IgG) and IgM antilipid antibodies in serum or plasma samples from blood donors. The Capture-S assay utilizes a modified Venereal Disease Research Laboratory antigen bound to microtitration wells and anti-IgG- plus anti-IgM-coated indicator eryth...

  9. Ultrasonic Communication Project, Phase 1, FY1999

    Energy Technology Data Exchange (ETDEWEB)

    Haynes, H.D.; Akerman, M.A.; Baylor, V.M.

    2000-06-01

    This Phase 1 project has been successful in identifying, exploring, and demonstrating methods for ultrasonic-based communication with an emphasis on the application of digital signal processing techniques. During the project, at the direction of the agency project monitor, particular attention was directed at sending and receiving ultrasonic data through air and through pipes that would be commonly found in buildings. Efforts were also focused on development of a method for transmitting computer files ultrasonically. New methods were identified and evaluated for ultrasonic communication. These methods are based on a technique called DFS. With DFS, individual alphanumeric characters are broken down into a sequence of bits, and each bit is used to generate a discrete ultrasonic frequency. Characters are then transmitted one-bit-at-a-time, and reconstructed by the receiver. This technique was put into practice through the development of LabVIEW{trademark}VIs. These VIs were integrated with specially developed electronic circuits to provide a system for demonstrating the transmission and reception/reconstruction of typed messages and computer files. Tests were performed to determine the envelope for ultrasound transmission through pipes (with and without water) versus through air. The practical aspects of connections, efficient electronics, impedance matching, and the effect of damping mechanisms were all investigated. These tests resulted in a considerable number of reference charts that illustrate the absorption of ultrasound through different pipe materials, both with and without water, as a function of distance. Ultrasound was found to be least attenuated by copper pipe and most attenuated by PVC pipe. Water in the pipe provides additional damping and attenuation of ultrasonic signals. Dramatic improvements are observed, however, in ultrasound signal strength if the transducers are directly coupled to the water, rather than simply attaching them to the outside of

  10. Fabrication, in vitro Degradation and Cytotoxic Assay of Different Cystalline Phases Calcium Polyphosphate

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Fabrication, in vitro degradation and cytotoxic assay of different crystalline phases calcium polyphosphate (CPP) were reported. The CPP ceramics were fabricated by crystallizing the amorphous frits , and sintered at 550 ℃ ,875 ℃ ,1000 ℃ for 1 h to obtain the γ-CPP, β-CPP anda-CPP respectively. The effects of the different crystalline phases on their weight loss and released PO4 3- were investigated during the degradation.And the surface change was observed by the SEM. The osteoblastic ROS17/2.8 cell line was used to estimate the cytotoxicity of CPP. The effects of CPP on cells' proliferation were evaluated by using MTT assay. The experimental results showed that γ-CPP, β- CPP and α-CPP did not exert cytotoxic effect on the cells. In addition, the proliferation of the growth of ROS17/2.8 cells on β-CPP was optimal.

  11. Evaluation of a solid-phase immunofluorescence assay for detection of antibodies to Legionella pneumophila.

    OpenAIRE

    Thompson, T. A.; Wilkinson, H W

    1982-01-01

    A semiautomated solid-phase immunofluorescence technique (FIAX) was compared with the standard indirect immunofluorescence assay (IFA) for the determination of antibody levels to Legionella pneumophila serogroup 1 in paired human serum samples. The FIAX method was in agreement with the IFA test for 91.8% of the serum pairs but gave evidence of a recent Legionella infection significantly fewer times than did the IFA. These results suggest that the FIAX technique may eventually be a useful alte...

  12. New methodological improvements in the Microtox® solid phase assay.

    Science.gov (United States)

    Burga Pérez, Karen F; Charlatchka, Rayna; Sahli, Leila; Férard, Jean-François

    2012-01-01

    The classic Microtox® solid phase assay (MSPA) based on the inhibition of light production of the marine bacteria recently renamed Aliivibrio fischeri suffers from various bias and interferences, mainly due to physico-chemical characteristics of the tested solid phase. To precisely assess ecotoxicity of sediments, we have developed an alternative method, named Microtox® leachate phase assay (MLPA), in order to measure the action of dissolved pollutants in the aqueous phase. Two hypotheses were formulated to explain the observed difference between MSPA and MLPA results: a real ecotoxicity of the solid phase or the fixation of bacteria to fine particles and/or organic matter. To estimate the latter, flow cytometry analyses were performed with two fluorochromes (known for their ability to stain bacterial DNA), allowing correction of MSPA measurements and generation of new (corrected) IC50. Comparison of results of MLPA with the new IC50 MSPA allows differentiating real ecotoxic and fixation effect in classic MSPA especially for samples with high amount of fines and/or organic matter. PMID:21962521

  13. Project WISH: The Emerald City, phase 2

    Science.gov (United States)

    1991-01-01

    The purpose of the Permanently Manned Autonomous Space Oasis, designated Project WISH: The Emerald City, is to serve as permanent living quarters for space colonists. In addition, it will serve as a stopover for space missions and will be capable of restationing itself practically anywhere within the solar system to provide support for these missions. The station should be self-sufficient, with no specific dependence on any resources from Earth. The 1990 to 1991 design team continued work started by last year's class. Further studies were conducted in the areas of orbital mechanics, propulsion, attitude control, and human factors. Critical elements were identified in each of these areas, and guidelines were established for the design of the Emerald City. Using the knowledge gained from these studies, two particular missions of interest, a Saturn Envelope mission and an Earth to Mars mission, were examined. The size and mass estimates, along with the methodologies used in their determination, are considered to be the main accomplishments of phase 2.

  14. Project Wish: The Emerald City, phase 3

    Science.gov (United States)

    1992-01-01

    Phase 3 of Project Wish saw the evolution of the Emerald City (E-City) from a collection of specialized independent analyses and ideas to a working structural design integrated with major support systems and analyses. Emphasis was placed on comparing and contrasting the closed and open cycle gas core nuclear rocket engines to further determine the optimum propulsive system for the C-City. Power and thermal control requirements were then defined and the question of how to meet these requirements was addressed. Software was developed to automate the mission/system/configuration analysis so changes dictated by various subsystems constraints could be managed efficiently and analyzed interactively. In addition, the liquid hydrogen propellant tank was statically designed for minimum mass and shape optimization using a finite element modeling package called SDRC I-DEAS while spoke and shaft cross-sectional areas were optimized on ASTROS (Automated Structural Optimization System). A structural dynamic analysis also conducted using ASTROS enabled a study of the displacements, accelerations, modes and frequencies of the C-City. Finally, the attitude control system design began with an initial mass moment of inertia analysis and was then designed and optimized using linear quadratic regulator control theory.

  15. Vapor Compressor Driven Hybrid Two-Phase Loop Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Phase I project successfully demonstrated the feasibility of the vapor compression hybrid two-phase loop (VCHTPL). The test results showed the high...

  16. Project Half Double, Preliminary Results for Phase 1, June 2016

    DEFF Research Database (Denmark)

    Svejvig, Per; Ehlers, Michael; Thorp Adland, Karoline;

    2016-01-01

    activities carried out within the framework of the projects. The formal part of Project Half Double was initiated in June 2015. We started out by developing, refining and testing the Half Double methodology on seven pilot projects in the first phase of the project, which will end June 2016. The current...

  17. Early Stakeholder Involvement in the Project Definition Phase: Case Renovation

    OpenAIRE

    Aki Aapaoja; Harri Haapasalo; Pia Söderström

    2013-01-01

    Relational project delivery methods (RPDMs) have been widely offered as a solution to increasing holistic project value creation. Furthermore, early stakeholder involvement has been emphasized as one of the cornerstones of RPDM. The purpose of this paper is to examine who the stakeholders are that should be involved early in the project definition phase. This paper discusses the process and nature of the project definition phase in RPDM, with the main focus on early stakeholder involvement. T...

  18. Low Cost Phased Array Antenna System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — JEM Engineering proved the technical feasibility of the FlexScan array?a very low-cost, highly-efficient, wideband phased array antenna?in Phase I, and stands ready...

  19. Airblast measurements, project diamond ore, Phase IIB

    International Nuclear Information System (INIS)

    Airblast measurements were made with two gages at each of three separate distances from the 20 cratering shots of Project Diamond Ore, Phase IIB. There were seven unstemmed single- charge shots, three unstemmed row-charge shots with three charges, three stemmed row-charge shots with five charges, two stemmed row-charge shots with three charges, and four shots with charges at or near the ground surface. Weights of individual charges ranged from 80 to 34,000 lbs. The unstemmed single-charge shots varied in depth of burial and permitted the attenuation of airblast parameters to be defined as a function of these depths. No comparison of the stemmed row-charge airblast with that from stemmed single charges was possible because no single charges have been fired in the same medium. No comparison was made for single-and row-charge unstemmed detonations because of differences in explosive, charge size, charge burial depth, and open-hole diameter. Differences in airburst from surface and near-surface bursts resulting from variances in charge position were less than differences caused by meteorological changes on the days the shots were fired. The single-charge data provided a further opportunity to evaluate the usefulness of airburst suppression with charge burial depth and stemming as an analog to suppression of radioactivity from nuclear cratering explosions. Airblast gas-venting impulse fractions out of the ground were in agreement with those obtained on one shot for radioactivity fraction using a radioactivity simulant. Airblast as an indicator of suppression has the advantage of being less dependent on local wind conditions. (U.S.)

  20. Development of solid phase immunoradiometric assay for determination of carcinoembryonic antigen as a tumor marker

    International Nuclear Information System (INIS)

    Development of solid phase coated tube immunoradiometric assay for estimation of carcinoembryonic antigen (CEA) was the aim of the present study. Labeling of CEA was carried out using Ch-T and iodogen as oxidizing agents and 125I. The tracers were used to test the presence of antibodies produced by immunization. Production of polyclonal antibody was carried out through immunization of four mice. After purification step, the tubes were coated by purified polyclonal antibodies. Immunoradiometric that system was performed using the commercial IZOTOP 125I-anti hCEA tracer then the validity studies were carried out. The results show that the local coated tubes made the assay is more than sufficient to fulfill the clinical requirement of CEA as a tumor marker. (author)

  1. Avionics Technology Contract Project Report Phase I with Research Findings.

    Science.gov (United States)

    Sappe', Hoyt; Squires, Shiela S.

    This document reports on Phase I of a project that examined the occupation of avionics technician, established appropriate committees, and conducted task verification. Results of this phase provide the basic information required to develop the program standards and to guide and set up the committee structure to guide the project. Section 1…

  2. Solid-phase tyrosine-specific protein kinase assay in multiwell substrate-immobilized polyacrylamide gel

    International Nuclear Information System (INIS)

    Since tyrosine-specific protein kinase (TPK) is much less abundant than Ser/Thr-specific kinases in cells, determination of TPK activity in crude cell extracts or column chromatography eluates has been difficult. This is compounded by the absence of a rapid, economical method for the separation of high endogenous protein phosphorylation background from exogenously added tyrosine-containing substrates. We have developed a new solid-phase assay, which provides high sensitivity and efficiency at a low cost for assaying the TPK activity of crude enzyme preparations. This assay utilizes immobilized tyrosine-containing synthetic polymers such as (Glu:Tyr, 4:1)n in polyacrylamide gels. The kinase reaction is started by adding crude enzyme solutions and [tau-32P]ATP-metal ion mixtures into microtiter-size wells made in the gels. After the phosphorylation reaction, the reaction mixtures are removed and the gels are prewashed in water followed by electrophoresis to completely remove free radioactive ATP. 32P incorporation into the immobilized TPK-specific substrate can be detected by autoradiography and quantitated by cutting the gel pieces and counting them with a liquid scintillation counter. The simple, rapid method should facilitate screening of TPK inhibitors and activators as well as examining the substrate specificity of TPKs. Other enzymes, including Ser/Thr-specific protein kinases, can also be analyzed by this technique

  3. Solid-phase group-specific adsorbants in assays for glycoproteins

    International Nuclear Information System (INIS)

    The focus of the paper is on several technical advances in the assays for glycoprotein hormones and enzymes that have been achieved by the use of the solid-phase cabohydrate-specific adsorbant concanavalin-A. Purification of glycoprotein radioligand after labelling by the Chloramine-T method is readily accomplished using a small column of agarose-bound concanavalin-A which separates glycoprotein radioligand from radioiodide and radiolabelled unadsorbed contaminants. After concanavalin-A column chromatography, radiolabelled glycoprotein hormone preparations exhibited improved binding to antibodies and tissue receptors. To increase the effective sensitivity of radioimmunoassays for glycoproteins, agarose-bound concanavalin-A is used to extract and concentrate the glycoproteins from various biological samples. For example, the effective sensitivity for the detection of human thyrotropin in serum was improved approximately 5-fold by using concanavalin-A concentrates of 1.5ml of serum. Partial purification of the glycoprotein dopamine-β-hydroxylase from serum using agarose-bound concanavalin-A resulted in separation of the serum factors that interfere with the measurement of enzyme activity. We conclude that in assays for glycoproteins, concanavalin-A is useful for purification of radioligand, for preparation of concentrates of glycoproteins from biological samples and for separation of glycoproteins from various interfering factors contained in biological samples before radioligand or radioenzyme assay. (author)

  4. Factors Affecting Sustainable Performance of Construction Projects during Project Life Cycle Phases

    Directory of Open Access Journals (Sweden)

    Adnan Enshassi

    2016-03-01

    Full Text Available Sustainable development (SD is one of the main challenges faced by the construction industry, which has acquired global attention. Sustainable performance (SP of a construction project during its life cycle (LC is considered crucial to achieve the SD. The aim of this paper is to investigate the factors affecting sustainable performance of construction projects throughout project life cycle phases in the Gaza Strip. A total of 53 sustainable factors (economic, social, and environmental sustainable factors were identified through extensive literature review and confirmed by experts’ interviews and a pilot study. These factors are classified in relation to the project life cycle phases; inception phase, design phase, construction phase, operation phase, and demolition phase. A structured questionnaire survey is employed in this study for primary data collection. A total of 119 questionnaires were distributed randomly to engineers working in construction projects in the Gaza Strip to solicit their views regarding the factors affecting sustainable performance of construction projects throughout project life cycle phases. The results revealed that five factors among the top ten factors that impacting the sustainable performance of construction projects are classified under the construction phase, which confirmed that the construction process has the most effect on the projects SP. Three factors are classified under the inception phase, which assured that the inception of a potential project has a considerable effect projects. In addition, one factor was classified under operation phase and one factor was classified under demolition phase. The most common factors affecting the SP of construction project through the overall sustainability elements: reusable/recyclable element, provision of services, energy consumption, water cost, and water pollution assessment. Further studies are recommended to explore how to integrated sustainability concepts into

  5. Application of a sepharose bead immunofluorescence assay and a solid-phase radioimmunoassay to the bovine leukemia virus system

    International Nuclear Information System (INIS)

    Several fluorescence assays with bovine leukemia virus (BLV) conjugated to activated Sepharose 4B were used for the detection of BLV and anti-BLV antibodies. These tests were compared with a solid-phase radioimmunoassay and found to be in the same sensitivity range. Sepharose bead immunofluorescence assay and solid-phase radioimmunoassay can be applied to the diagnosis of BLV infection in cattle. (author)

  6. Low Cost Phased Array Antenna System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A program is proposed to research the applicability of a unique phased array technology, dubbed FlexScan, to S-band and Ku-band communications links between...

  7. Pancharatnam geometric phase originating from successive partial projections

    Indian Academy of Sciences (India)

    Sohrab Abbas; Apoorva G Wagh

    2008-11-01

    The spin of a polarized neutron beam subjected to a partial projection in another direction, traces a geodesic arc in the 2-sphere ray space. We delineate the geometric phase resulting from two successive partial projections on a general quantal state and derive the direction and strength of the third partial projection that would close the geodesic triangle. The constraint for the three successive partial projections to be identically equivalent to a net spin rotation regardless of the initial state, is derived.

  8. Tank waste remediation system privatization Phase 1 infrastructure, project W-519, project execution plan

    International Nuclear Information System (INIS)

    This Project Execution Plan (PEP) defines the overall strategy, objectives, and contractor management requirements for the execution phase of Project W-519 (98-D403), Privatization Phase 1 Infrastructure Support, whose mission is to effect the required Hanford site infrastructure physical changes to accommodate the Privatization Contractor facilities. This plan provides the project scope, project objectives and method of performing the work scope and achieving objectives. The plan establishes the work definitions, the cost goals, schedule constraints and roles and responsibilities for project execution. The plan also defines how the project will be controlled and documented

  9. Project Initiation Document Phase Two: Scoping Exercise within mainstream schools

    OpenAIRE

    Public Health Agency

    2015-01-01

    This Project Initiation Document outlines the purpose and plan of Phase Two of the Review of AHP Support for Children with Statements of Special Educational Needs in Special Schools and Mainstream Education.

  10. Project Initiation Document Phase One: Scoping Exercise within special schools

    OpenAIRE

    Public Health Agency

    2014-01-01

    This Project Initiation Document outlines the purpose and plan of Phase One of the Review of AHP Support for Children with Statements of Special Educational Needs in Special Schools and Mainstream Education.

  11. Development of kits for radioimmunometric assays for tumour markers. Final report of a co-ordinated research project 1997-2001

    International Nuclear Information System (INIS)

    Many tumour marker assays have been reported over the years and their role is well recognized and acknowledged in the follow-up of known cancer cases. However, their true potential for use in primary diagnosis or screening of high risk groups is still to be fully realized due to the need to achieve better specificity. Among the various tumour markers, the one for prostate cancer - prostate specific antigen (PSA) - appears to have better specificity, coming close to a tumour specific antigen. Prostate cancer is a commonly encountered cancer in men, and can be effectively treated if detected early. PSA levels in serum appear to provide good correlation with tumour burden. Estimation of free PSA in serum is reported to further improve the diagnosis. In several developed countries routine screening of men above 50 years of age for prostate cancer using serum PSA as marker is recommended. Radioimmunometric assay techniques offer themselves as attractive candidates for measurement of tumour markers. They are robust, economical and didactic, thus eminently suitable for technology transfer, training and teaching. Preparation of primary reagents is relatively easy. The methodology is flexible. As a result of co-operation projects of the IAEA, many developing Member States have built up indigenous capabilities to perform radioimmunometric assays, which can be extended to development of kits for tumour marker assays. Considering the need for indigenous development of capabilities to produce reliable kits for radioimmunometric assays for PSA, in 1997 the IAEA initiated a Co-ordinated Research Project (CRP) on Development of Kits for Radioimmunometric Assays for Tumour Markers. Even though the focus of the project was PSA, it was expected that the expertise to be gained by the participants would also help them undertake development of kits for other tumour markers, essentially using the same methodology. Ten laboratories from Europe, Asia, Africa and the Americas participated

  12. A simple and cost-effective solid-phase protein nano-assay using polyacrylamide-coated glass plates.

    Science.gov (United States)

    Krajewski, Wladyslaw A

    2015-02-01

    A new solid-phase protein nano-assay is suggested for simple and sensitive estimation of protein content in sample buffers (a 1-μl sample is sufficient for analysis). The assay is different from conventional "on-filter" assays in that it uses inexpensive fully transparent polyacrylamide gel (PAAG)-coated glass plates as solid support and, thus, combines the convenience of "on-membrane" staining with the sensitivity and ease of documentation of "in-gel" staining (and, therefore, is especially suited for standard lab gel documentation systems). The PAAG plates assay is compatible with all dyes for in-gel protein staining. Depending on the sensitivity of the staining protocol, the assay can be used in macro-, micro-, and nano-assay formats. We also describe a low-cost two-component colloidal Coomassie brilliant blue G-250 (CBB G-250) staining protocol for fast quantitative visualization of proteins spotted on a PAAG plate (the detection limit is up to 2 ng of proteins even when using a Nikon CoolPix digital camera and white light transilluminator instead of a gel scanner). The suggested colloidal CBB G-250 protocol could also be used for visualizing nano-amounts of proteins in polyacrylamide gels. The PAAG plate assay could be useful for proteomic applications and, in general, for all cases where a fast, sensitive, and easily documentable cost-effective solid-phase protein assay is required. PMID:25449300

  13. A solid phase radioimmunoassay for free triiodothyronine in serum:assay development and validation

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    A solid phase radioimmunoassay for free triiodothyroninein serum was developed based on double-antibody coated tubes.The method was turned out to be reliable with good reproducibility,higher sensitivity and easy performance.The measurable range of FT3 in serum was 1.2 to 38pmol/L.The mean coefficients of variationwithin and between assays were 1.79%~3.18% and 4.72%~9.31%,respectively.The FT3 concentrations in euthyroid serum as determined by this methodwere 2.8 to 7.8pmol/L.The FT3 values determined by this new methodcorrelated well with those measured by a commercial radioimmunoassay(r=0.853).

  14. A solid-phase dot assay using silica/gold nanoshells

    Directory of Open Access Journals (Sweden)

    Zharov Vladimir

    2006-01-01

    Full Text Available AbstractWe report on the first application of silica-gold nanoshells to a solid-phase dot immunoassay. The assay principle is based on staining of a drop (1 µl analyte on a nitrocellulose membrane strip by using silica/gold nanoshells conjugated with biospecific probing molecules. Experimental example is human IgG (hIgG, target molecules and protein A (probing molecules. For usual 15-nm colloidal gold conjugates, the minimal detectable amount of hIgG is about 4 ng. By contrast, for nanoshell conjugates (silica core diameter of 70 nm and gold outer diameter of 100 nm we have found significant increase in detection sensitivity and the minimal detectable amount of hIgG is about 0.5 ng. This finding is explained by the difference in the monolayer particle extinction.

  15. A simple and safe method for single HLA-antigen-typing by a solid phase assay.

    Science.gov (United States)

    Häcker-Shahin, B; Giannitsis, D J

    1991-01-01

    A rapid solid phase assay for detection of single HLA-antigens on platelets was developed. The platelets were attached to the surface of polystyrene microtitre plate wells by means of a sodium carbonate buffer and centrifugation. Uncovered areas were blocked by a gelatin blocking buffer. After incubation with commercially available anti-HLA-sera the bound anti-HLA-specific antibodies directed against HLA-antigens present on the platelets were made visible by anti-IgG-coated indicator red cells and a brief centrifugation. A positive result, meaning the presence of an HLA-antigen, was indicated by a slight red cell adherence over the reaction surface. In the absence of the HLA-antigen no binding occurred and the indicator red cells formed a small red disc-like pellet. PMID:1954783

  16. The Lunar Phases Project: A Mental Model-Based Observational Project for Undergraduate Nonscience Majors

    Science.gov (United States)

    Meyer, Angela Osterman; Mon, Manuel J.; Hibbard, Susan T.

    2011-01-01

    We present our Lunar Phases Project, an ongoing effort utilizing students' actual observations within a mental model building framework to improve student understanding of the causes and process of the lunar phases. We implement this project with a sample of undergraduate, nonscience major students enrolled in a midsized public university located…

  17. Code of Conduct for wind-power projects - Phase 3

    International Nuclear Information System (INIS)

    This paper discusses the results of phase three of a project concerning wind-power projects. Feasibility and strategy aspects are examined and discussed. The current state of the wind power market is discussed on the basis of the results of a survey made on the subject. The social acceptance of wind power installations is discussed, whereby the rejection of particular projects is compared with a general lack of acceptance. Requirements placed on such projects and possible solutions are discussed. Finally, the feasibility of setting up a code of conduct in the area of wind-power projects is discussed and the definition of further instruments is examined

  18. Best practice influence on project changes during the construction phase.

    OpenAIRE

    Ciaravino, Brian Douglas.

    1998-01-01

    CIVINS This thesis analyzes the influence of team building, constructability, and project change management best practices on the reduction of project changes during the construction phase. Construction Industry Institute Owner, Naval Facilities Command, and Construction Industry Institute Contractor data are separately evaluated to determine if a statistically significance relationship between best practice use and a reduction in the project change rate during construction exists. Conclus...

  19. FY 1991 project plan for the Hanford Environmental Dose Reconstruction Project, Phase 2

    International Nuclear Information System (INIS)

    Phase 1 of the Hanford Environmental Dose Reconstruction Project was designed to develop and demonstrate a method for estimating radiation doses people may have received from Hanford Site operations since 1944. The method researchers developed relied on a variety of measured and reconstructed data as input to a modular computer model that generates dose estimates and their uncertainties. As part of Phase 1, researchers used the reconstructed data and computer model to calculate preliminary dose estimates for populations in a limited geographical area and time period. Phase 2, now under way, is designed to evaluate the Phase 1 data and model and improve them to calculate more accurate and precise dose estimates. Phase 2 will also be used to obtain preliminary estimates of two categories of doses: for Native American tribes and for individuals included in the pilot phase of the Hanford Thyroid Disease Study (HTDS). TSP Directive 90-1 required HEDR staff to develop Phase 2 task plans for TSP approval. Draft task plans for Phase 2 were submitted to the TSP at the October 11--12, 1990 public meeting, and, after discussions of each activity and associated budget needs, the TSP directed HEDR staff to proceed with a slate of specific project activities for FY 1991 of Phase 2. This project plan contains detailed information about those activities. Phase 2 is expected to last 15--18 months. In mid-FY 1991, project activities and budget will be reevaluated to determine whether technical needs or priorities have changed. Separate from, but related to, this project plan, will be an integrated plan for the remainder of the project. HEDR staff will work with the TSP to map out a strategy that clearly describes ''end products'' for the project and the work necessary to complete them. This level of planning will provide a framework within which project decisions in Phases 2, 3, and 4 can be made

  20. Holographic and weak-phase projection system for 3D shape reconstruction using temporal phase unwrapping

    Science.gov (United States)

    González, C. A.; Dávila, A.; Garnica, G.

    2007-09-01

    Two projection systems that use an LCoS phase modulator are proposed for 3D shape reconstruction. The LCoS is used as an holographic system or as a weak phase projector, both configurations project a set of fringe patterns that are processed by the technique known as temporal phase unwrapping. To minimize the influence of camera sampling, and the speckle noise in the projected fringes, an speckle noise reduction technique is applied to the speckle patterns generated by the holographic optical system. Experiments with 3D shape reconstruction of ophthalmic mold and other testing specimens show the viability of the proposed techniques.

  1. Integrated Monitoring and Surveillance System demonstration project. Phase 2 accomplishments

    International Nuclear Information System (INIS)

    The paper presents the results of the Integrated Monitoring and Surveillance System (IMSS) demonstration project Phase 2 efforts. the rationale behind IMSS development is reviewed and progress in each of the 5 basic tasks is detailed. Significant results include further development of the data acquisition system and procurement of necessary hardware/software, options and associated costs for plutonium canning systems and gloveboxes, initiation of facility modifications, determination of possibly affected facility documentation, results from sensor system trade study, and preliminary storage configuration designs. Resources invested during Phase 1 and Phase 2 are summarized and budgetary requirements for completion of Phase 3 presented. The results show that the IMSS demonstration project team has met and in many cases exceeded the commitments made for Phase 2 deliverables

  2. Uncertainty in project phases: A framework for organisational change management

    DEFF Research Database (Denmark)

    Kreye, Melanie; Balangalibun, Sarah

    2015-01-01

    Uncertainty is an integral challenge when managing organisational change projects (OCPs). Current literature highlights the importance of uncertainty; however, falls short of giving insights into the nature of uncertainty and suggestions for managing it. Specifically, no insights exist on how...... early stage of the change project but was delayed until later phases. Furthermore, the sources of uncertainty were found to be predominantly within the organisation that initiated the change project and connected to the project scope. Based on these findings, propositions for future research are defined...

  3. Current status of Horonobe URL project in construction phase

    International Nuclear Information System (INIS)

    The Horonobe URL project has been pursued by JAEA (Japan Atomic Energy Agency) to establish and demonstrate site characterization methodologies, engineering technologies, and safety assessment methodologies for HLW geological disposal in relevant geological environment with sedimentary rock and saline groundwater distributing in the Horonobe area, Hokkaido, Japan. In the Horonobe URL project, surface-based investigation phase (Phase I) has already completed in the year 2005, and then construction phase (Phase II) has initiated in the same year. Currently, construction of the underground facilities such as shafts/galleries which were designed in Phase I, investigations of the geological environment in the excavated shafts/galleries and confirmation of applicability of engineering technologies has been alternately carried out as Phase II activities of the project. During the construction so far, monitoring for the construction safety such as convergence measurements, tunnel wall observation, sampling of groundwater and rock, investigations for evaluating excavation damaged/disturbed zone (EDZ/EdZ) along shafts/galleries were carried out. In addition, a shotcrete construction test and a grout injection test by using low alkaline cement material were carried in the horizontal galleries. In this paper, status of the URL construction and research activities mentioned above are outlined as the current achievement of the Horonobe URL project. (author)

  4. Integrated monitoring and surveillance system demonstration project: Phase I accomplishments

    Energy Technology Data Exchange (ETDEWEB)

    Aumeier, S.E.; Walters, B.G.; Crawford, D.C. [and others

    1997-01-15

    The authors present the results of the Integrated Monitoring and Surveillance System (IMSS) demonstration project Phase I efforts. The rationale behind IMSS development is reviewed and progress in each of the 5 basic tasks is detailed. Significant results include decisions to use Echelon LonWorks networking protocol and Microsoft Access for the data system needs, a preliminary design for the plutonium canning system glovebox, identification of facilities and materials available for the demonstration, determination of possibly affected facility documentation, and a preliminary list of available sensor technologies. Recently imposed changes in the overall project schedule and scope are also discussed and budgetary requirements for competition of Phase II presented. The results show that the IMSS demonstration project team has met and in many cases exceeded the commitments made for Phase I deliverables.

  5. Time-resolved rotation projection MR phase contrast angiography

    International Nuclear Information System (INIS)

    In view of the advantages of time-resolved phase contrast angiography, the authors have investigated the additional advantage of incrementing projection angle during the cardiac cycle. An electrocardiographically triggered, multisection sequence was modified to produce bipolar gradient-reversal phase-contrast angiograms at 45-msec intervals. The projection angle for each angiogram was incremented by 5 degrees. Asymmetric echo acquisition was used to minimize TE. Velocity-compensated field-of-view select and readout gradients were used. Acceleration-compensated velocity encoding and velocity-compensated phase encoding gradients were investigated. A weak dephasing gradient was used in the projection direction. Images were acquired at 16 angles with four excitations per angle; acquisition time was approximately 8 minutes for each velocity component

  6. Integrated monitoring and surveillance system demonstration project: Phase I accomplishments

    International Nuclear Information System (INIS)

    The authors present the results of the Integrated Monitoring and Surveillance System (IMSS) demonstration project Phase I efforts. The rationale behind IMSS development is reviewed and progress in each of the 5 basic tasks is detailed. Significant results include decisions to use Echelon LonWorks networking protocol and Microsoft Access for the data system needs, a preliminary design for the plutonium canning system glovebox, identification of facilities and materials available for the demonstration, determination of possibly affected facility documentation, and a preliminary list of available sensor technologies. Recently imposed changes in the overall project schedule and scope are also discussed and budgetary requirements for competition of Phase II presented. The results show that the IMSS demonstration project team has met and in many cases exceeded the commitments made for Phase I deliverables

  7. Improving decision making in the early phases of configuration projects

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Harlou, Ulf; Haug, Anders

    2008-01-01

    configuration projects. Each of the five phases is sup¬ported by a set of tools. The main idea of the pro¬cedure is utili¬zation of a so-called Product Family Master Plan, which is a formal description of the product assortment and its variation. The procedure has been tested at one of Baan's cus¬tomers with......During the early phases of configuration projects very important decisions are made which will heavily influence the performance of the company, benefits in different functional areas (production, sales, purchase, product development, service etc), maintenance of the configuration system and...... quality of the dialogue between the configuration system and the users. Today there exists very sparse tools and procedures which can assist the early phases, i.e. conceptual modeling of the products and prod¬uct assortment. This paper presents a five-phase procedure for conceptual mod¬eling in...

  8. Improving decision making in the early phases of configuration projects

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Harlou, Ulf; Haug, Anders

    2008-01-01

    During the early phases of configuration projects very important decisions are made which will heavily influence the performance of the company, benefits in different functional areas (production, sales, purchase, product development, service etc), maintenance of the configuration system and...... configuration projects. Each of the five phases is sup¬ported by a set of tools. The main idea of the pro¬cedure is utili¬zation of a so-called Product Family Master Plan, which is a formal description of the product assortment and its variation. The procedure has been tested at one of Baan's cus¬tomers with...

  9. Improving decision making in the early phases of configuration projects

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Hvam, Lars; Harlou, Ulf;

    2011-01-01

    During the early phases of configuration projects very important decisions are made which will heavily influence the performance of the company, benefits in different functional areas (production, sales, purchase, product development, service etc), maintenance of the configuration system and...... configuration projects. Each of the five phases is supported by a set of tools. The main idea of the procedure is utilization of a so-called Product Family Master Plan, which is a formal description of the product assortment and its variation. The procedure has been tested at one of Baan's (SSA Global...

  10. Cholesterol transport via ABCA1: new insights from solid-phase binding assay.

    Science.gov (United States)

    Reboul, Emmanuelle; Dyka, Frank M; Quazi, Faraz; Molday, Robert S

    2013-04-01

    It is now well established that the ATP-binding cassette transporter A1 (ABCA1) plays a pivotal role in HDL metabolism, reverse cholesterol transport and net efflux of cellular cholesterol and phospholipids. We aimed to resolve some uncertainties related to the putative function of ABCA1 as a mediator of lipid transport by using a methodology developed in the laboratory to isolate a protein and study its interactions with other compounds. ABCA1 was tagged with the 1D4 peptide at the C terminus and expressed in human HEK 293 cells. Preliminary experiments showed that the tag modified neither the protein expression/localization within the cells nor the ability of ABCA1 to promote cholesterol cellular efflux to apolipoprotein A-I. ABCA1-1D4 was then purified and reconstituted in liposomes. ABCA1 displayed an ATPase activity in phospholipid liposomes that was significantly decreased by cholesterol. Finally, interactions with either cholesterol or apolipoprotein A-I were assessed by binding experiments with protein immobilized on an immunoaffinity matrix. Solid-phase binding assays showed no direct binding of cholesterol or apolipoprotein A-I to ABCA1. Overall, our data support the hypothesis that ABCA1 is able to mediate the transport of cholesterol from cells without direct interaction and that apo A-I primarily binds to membrane surface or accessory protein(s). PMID:23201557

  11. Evolution of classical projected phase space density in billiards

    Indian Academy of Sciences (India)

    Debabrata Biswas

    2005-04-01

    The classical phase space density projected on to the configuration space offers a means of comparing classical and quantum evolution. In this alternate approach that we adopt here, we show that for billiards, the eigenfunctions of the coarse-grained projected classical evolution operator are identical to a first approximation to the quantum Neumann eigenfunctions. Moreover, there exists a correspondence between the respective eigenvalues although their time evolutions differ.

  12. Phase 1 of the Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-01

    The work described in this report was prompted by the public's concern about potential effect from the radioactive materials released from the Hanford Site. The Hanford Environmental Dose Reconstruction (HEDR) Project was established to estimate radiation dose the public might have received from the Hanford Site since 1944, when facilities began operating. Phase 1 of the HEDR Project is a pilot'' or demonstration'' phase. The objectives of this initial phase were to determine whether enough historical information could be found or reconstructed to be used for dose estimation and develop and test conceptual and computational models for calculating credible dose estimates. Preliminary estimates of radiation doses were produced in Phase 1 because they are needed to achieve these objectives. The reader is cautioned that the dose estimates provided in this and other Phase 1 HEDR reports are preliminary. As the HEDR Project continues, the dose estimates will change for at least three reasons: more complete input information for models will be developed; the models themselves will be refined; and the size and shape of the geographic study area will change. This is one of three draft reports that summarize the first phase of the four-phased HEDR Project. This, the Summary Report, is directed to readers who want a general understanding of the Phase 1 work and preliminary dose estimates. The two other reports -- the Air Pathway Report and the Columbia River Pathway Report -- are for readers who understand the radiation dose assessment process and want to see more technical detail. Detailed descriptions of the dose reconstruction process are available in more than 20 supporting reports listed in Appendix A. 32 refs., 46 figs.

  13. Phase 1 of the Hanford Environmental Dose Reconstruction Project

    International Nuclear Information System (INIS)

    The work described in this report was prompted by the public's concern about potential effect from the radioactive materials released from the Hanford Site. The Hanford Environmental Dose Reconstruction (HEDR) Project was established to estimate radiation dose the public might have received from the Hanford Site since 1944, when facilities began operating. Phase 1 of the HEDR Project is a ''pilot'' or ''demonstration'' phase. The objectives of this initial phase were to determine whether enough historical information could be found or reconstructed to be used for dose estimation and develop and test conceptual and computational models for calculating credible dose estimates. Preliminary estimates of radiation doses were produced in Phase 1 because they are needed to achieve these objectives. The reader is cautioned that the dose estimates provided in this and other Phase 1 HEDR reports are preliminary. As the HEDR Project continues, the dose estimates will change for at least three reasons: more complete input information for models will be developed; the models themselves will be refined; and the size and shape of the geographic study area will change. This is one of three draft reports that summarize the first phase of the four-phased HEDR Project. This, the Summary Report, is directed to readers who want a general understanding of the Phase 1 work and preliminary dose estimates. The two other reports -- the Air Pathway Report and the Columbia River Pathway Report -- are for readers who understand the radiation dose assessment process and want to see more technical detail. Detailed descriptions of the dose reconstruction process are available in more than 20 supporting reports listed in Appendix A. 32 refs., 46 figs

  14. Screening ToxCast™ Phase I Chemicals in a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) Assay

    Science.gov (United States)

    An Adherent Cell Differentiation and Cytotoxicity (ACDC) in vitro assay with mouse embryonic stem cells was used to screen the ToxCast Phase I chemical library for effects on cellular differentiation and cell number. The U.S. Environmental Protection Agency (EPA) established the ...

  15. The international INTRAVAL project. Phase 2, Summary report

    International Nuclear Information System (INIS)

    The international project INTRAVAL addresses the validation of models of transport of radionuclides through groundwater in the geosphere. Such models are used in the assessment of the long-term safety of radioactive waste disposal systems. The second phase of INTRAVAL, which started in 1990, was concluded at the end of 1993. The objective of Phase 2 was to increase the understanding how various geophysical, geohydrological and geochemical phenomena of importance for radionuclide transport from a repository to the biosphere could be described by mathematical models and to study the model validation process. Summarized results from Phase 2 of the INTRAVAL study are presented in this report. (K.A.)

  16. Phase-aware projection model for steganalysis of JPEG images

    Science.gov (United States)

    Holub, Vojtěch; Fridrich, Jessica

    2015-03-01

    State-of-the-art JPEG steganographic algorithms, such as J-UNIWARD, are currently better detected in the spatial domain rather than the JPEG domain. Rich models built from pixel residuals seem to better capture the impact of embedding than features constructed as co-occurrences of quantized JPEG coefficients. However, when steganalyzing JPEG steganographic algorithms in the spatial domain, the pixels' statistical properties vary because of the underlying 8 × 8 pixel grid imposed by the compression. In order to detect JPEG steganography more accurately, we split the statistics of noise residuals based on their phase w.r.t. the 8 × 8 grid. Because of the heterogeneity of pixels in a decompressed image, it also makes sense to keep the kernel size of pixel predictors small as larger kernels mix up qualitatively different statistics more, losing thus on the detection power. Based on these observations, we propose a novel feature set called PHase Aware pRojection Model (PHARM) in which residuals obtained using a small number of small-support kernels are represented using first-order statistics of their random projections as in the projection spatial rich model PSRM. The benefit of making the features "phase-aware" is shown experimentally on selected modern JPEG steganographic algorithms with the biggest improvement seen for J-UNIWARD. Additionally, the PHARM feature vector can be computed at a fraction of computational costs of existing projection rich models.

  17. Three phases of the Pacific Islands Project (1995-2010).

    Science.gov (United States)

    Watters, David A K; Ewing, Hamish; McCaig, Eddie

    2012-05-01

    The Pacific Islands Project (PIP), funded by AusAid and managed by the Royal Australasian College of Surgeons (RACS), has progressed through three phases from 1995 to 2010. During this time, it has sent over 520 teams to 11 Pacific Island Countries, providing over 60,000 consultations and some 16,000 procedures. In addition to this delivery of specialist medical and surgical services that were not previously available in-country, the project has contributed as a partner in capacity building with the Fiji School of Medicine and Ministries of Health of the individual nations. By 2011, Fiji School of Medicine, which began postgraduate specialist training in 1998, had awarded 51 doctors a diploma in surgery (1 year), 20 of whom had completed their Masters in Medicine (4 years). PIP was independently evaluated on completion of every phase, including the bridging Phase III (2006-2010). The project delivered on its design, to deliver services, and also helped build capacity. The relationship established with the RACS throughout the project allowed Pacific Island graduates to access the Rowan Nicks scholarship, and the majority of MMed graduates received International Travel Grants to attend the Annual Scientific Meeting. PIP has been a highly successful partnership in delivering and building specialist medical services. Although AusAid contributed some $20 million over 16 years, the value added from pro bono contributions by Specialist Teams, Specialty Coordinators and the Project Directors amounted to an equivalent amount. With the emergence of Pacific Island-trained specialists, PIP is ready to move into a new phase where the agendas are set, monitored and managed within the Pacific, and RACS fulfils the role of a service provider. A critical mass of Pacific Island surgeons has been trained, so that sub-specialization will be an option for the general surgeons of the larger island nations. PMID:22507204

  18. Program for the Stripa Project Phase 3 1986-1991

    International Nuclear Information System (INIS)

    The history of the planning and implementation of Phase 3 of the OECD/NEA Stripa Project encompasses a time period of over two years. At a meeting of the Technical Subgroups in Sweden in September 1984, it was decided that a more comprehensive plan with well defined goals should be developed prior to initiating any further investigations of fluid flow in fractured rock masses at the Stripa Mine. During the months following that meeting, a small group of technical specialists met for the purpose of developing a preliminary notion of how to integrate site characterization, groundwater flow and transport, and geochemistry technology in future investigations at the Stripa Mine. Consideration would be given to a sizable volume of rock mass in the Stripa Mine for the purpose of such investigations. Additionally, the Principal Investigator for the borehole and shaft sealing tests was asked to suggest an initial framework of an integrated project that covered the research areas of interest to engineered barriers and rock mechanics. In March 1985, the Technical Subgroups convened a meeting in Switzerland. During that meeting, a preliminary program for a tentative Phase 3 of the Stripa Project was discussed. The intended duration of a Phase 3 was established as five years, beginning in 1986. Emphasis would be placed on investigations that would represent an integration of the technical knowledge developed in Phases 1 and 2 of the Stripa Project. Specific goals were established, and proposals for tentative investigations were reviewed. In June 1985, the following general objectives of a third phase were agreed upon: To integrate various site characterization techniques and methods of analysis for the prediction and validation of ground-water flow and nuclide transport in an unexplored volume of Stripa granite. To demonstrate and verify the use of different materials and techniques for sealing ground-water flow paths in the Stripa granite. 3 figs., 21 tabs

  19. SOLID-PHASE ASSAY FOR THE PHOSPHORYLATION OF PROTEINS BLOTTED ON NITROCELLULOSE MEMBRANE FILTERS

    Science.gov (United States)

    A new procedure for the phosphorylation and assay of phosphoproteins is described. Proteins are solubilized from tissue samples, separated by polyacrylamide gel electrophoresis, transferred onto nitrocellulose membrane filters and the blotted polypeptides are phosphorylated with ...

  20. Advanced conceptual design report solid waste retrieval facility, phase I, project W-113

    International Nuclear Information System (INIS)

    Project W-113 will provide the equipment and facilities necessary to retrieve suspect transuranic (TRU) waste from Trench 04 of the 218W-4C burial ground. As part of the retrieval process, waste drums will be assayed, overpacked, vented, head-gas sampled, and x-rayed prior to shipment to the Phase V storage facility in preparation for receipt at the Waste Receiving and Processing Facility (WRAP). Advanced Conceptual Design (ACD) studies focused on project items warranting further definition prior to Title I design and areas where the potential for cost savings existed. This ACD Report documents the studies performed during FY93 to optimize the equipment and facilities provided in relation to other SWOC facilities and to provide additional design information for Definitive Design

  1. Advanced conceptual design report solid waste retrieval facility, phase I, project W-113

    Energy Technology Data Exchange (ETDEWEB)

    Smith, K.E.

    1994-03-21

    Project W-113 will provide the equipment and facilities necessary to retrieve suspect transuranic (TRU) waste from Trench 04 of the 218W-4C burial ground. As part of the retrieval process, waste drums will be assayed, overpacked, vented, head-gas sampled, and x-rayed prior to shipment to the Phase V storage facility in preparation for receipt at the Waste Receiving and Processing Facility (WRAP). Advanced Conceptual Design (ACD) studies focused on project items warranting further definition prior to Title I design and areas where the potential for cost savings existed. This ACD Report documents the studies performed during FY93 to optimize the equipment and facilities provided in relation to other SWOC facilities and to provide additional design information for Definitive Design.

  2. DISS-phase II PROJECT. Final Project Report (December, 1998 to December, 2001)

    Energy Technology Data Exchange (ETDEWEB)

    Zarza, E.

    2002-07-01

    The DISS project is a complete R+TD program aimed at developing a new generation of Solar Thermal Power Plants with improved parabolic trough collectors and direct solar steam generation in the absorber pipes. Due to the complex tasks to be performed, the plan of work was divided into several consecutive phases. The first phase was carried out during the period from 1996 to 1998. This final report completes the second phase (DISS.Phase II), which was partially funded by European Commission contract JOR3-CT98-0277. It is the logical continuation of the first phase. This project was carried out from December, 1998 to December, 2001, by an international team co-ordinated by CIEMAT. The project partners are: CIEMAT (Spanish research center) DLR (German research institution), ENDESA (Spanish electric utility), Iberdrola (Spanish electric utility), INABENSA (Spanish industry), INITEC (Spanish engineering company), FLABEG Solar (German industry), and ZSW (German research center). As usual in any R+TD project where new technologies and prototypes are developed,huge technical problems had to be faced. Nevertheless, throughout the project, with the great effort and dedication of all the Partners, the technical difficulties impeding the success of our main objective, experimental research on the feasibility of the three basic DSG options (i. e. once-through, recirculation and injection), were solved. The capability of the Partners for undertaking technically challenging and complex R+TD programs has also been clearly demonstrated. The most important conclusion that may be derived from the project is the certainty that direct solar steam generation is possible in parabolic trough collectors with horizontal absorber tubes. Valuable know-how and experience were gained and commercial DSG solar plant design tools were developed during the project which represents a significant step forward in the development of this new technology. Since the list of names is too long. I would

  3. The first phase of the MARE project in Milano

    International Nuclear Information System (INIS)

    The international project 'Microcalorimeter Arrays for a Rhenium Experiment' (MARE) aims at the direct and calorimetric measurement of the electron anti-neutrino mass with sub-electronvolt sensitivity. The experimental strategy consists in studying the beta spectrum of 187Re near the end-point looking for the spectral distortion expected for a finite anti-neutrino mass. The MARE project has a staged approach: in the final experimental phase (MARE-2), several large arrays with as many as 10 000 detectors each will be deployed to collect the statistics required to probe the anti-neutrino mass with a sensitivity of at least 0.2 eV, comparable to the one expected for the Katrin experiment (KATRIN LoI, 2001, ). In the short term, smaller scale experiments are planned to reach sensitivities of the order of 1 eV (MARE-1). This contribution reports on the Milano group activity for the MARE project.

  4. Solid-phase assay for the phosphorylation of proteins blotted on nitrocellulose membrane filters

    International Nuclear Information System (INIS)

    A new procedure for the phosphorylation and assay of phosphoproteins is described. Proteins are solubilized from tissue samples, separated by polyacrylamide gel electrophoresis, transferred onto nitrocellulose membrane filters, and the blotted polypeptides are phyosphorylated with the catalytic subunit of cyclic AMP (adenosine 3':5'-monophosphate)-dependent protein kinase. The method was developed for the assay of dephosphosynapsin I, but it has also proven suitable for the phosphorylation of other proteins. The patterns of phosphorylation of tissue samples phosphorylated using the new method are similar to those obtained using the conventional test tube assay. Once phosphorylated, the adsorbed proteins can be digested with proteases and subjected to phosphopeptide mapping. The phosphorylated blotted proteins can also be analyzed by overlay techniques for the immunological detection of polypeptides

  5. Environmental information volume: Liquid Phase Methanol (LPMEOH{trademark}) project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    The purpose of this project is to demonstrate the commercial viability of the Liquid Phase Methanol Process using coal-derived synthesis gas, a mixture of hydrogen and carbon monoxide. This report describes the proposed actions, alternative to the proposed action, the existing environment at the coal gasification plant at Kingsport, Tennessee, environmental impacts, regulatory requirements, offsite fuel testing, and DME addition to methanol production. Appendices include the air permit application, solid waste permits, water permit, existing air permits, agency correspondence, and Eastman and Air Products literature.

  6. Environmental information volume: Liquid Phase Methanol (LPMEOH trademark) project

    International Nuclear Information System (INIS)

    The purpose of this project is to demonstrate the commercial viability of the Liquid Phase Methanol Process using coal-derived synthesis gas, a mixture of hydrogen and carbon monoxide. This report describes the proposed actions, alternative to the proposed action, the existing environment at the coal gasification plant at Kingsport, Tennessee, environmental impacts, regulatory requirements, offsite fuel testing, and DME addition to methanol production. Appendices include the air permit application, solid waste permits, water permit, existing air permits, agency correspondence, and Eastman and Air Products literature

  7. Capabilities for frequent innovation : Managing the early project phases in the pharmaceutical R&D process

    OpenAIRE

    Biedenbach, Thomas

    2011-01-01

    Despite their recognized significance for project success and innovation, the management of the early project phases is still an under-researched area in project management. For organizations to secure a continuous stream of innovation, the utilization of capabilities is crucial for managing the early phases of R&D projects. The purpose of this dissertation is to advance the understanding of the management of the early project phases in hypercompetitive environments. The thesis addresses ...

  8. SELDI Phase I: Assay Validation-Prostate — EDRN Public Portal

    Science.gov (United States)

    It is then the goal of this collaborative project – EDRN-Prostate-SELDI Investigational Collaboration (EPSIC) - to use state-of-the-art protein profiling technology to develop and validate such screening methods

  9. Quality assurance/quality control of foot and mouth disease solid phase competition enzyme-linked immunosorbent assay--Part II. Quality control: comparison of two charting methods to monitor assay performance.

    Science.gov (United States)

    Goris, N; De Clercq, K

    2005-12-01

    Diagnostic laboratories are increasingly required to meet stringent quality standards, and validated assays are needed to achieve formal accreditation. Validation of test methods is often considered to be finalised when the assay parameters and characteristics have been established. However, like any process, diagnostic assays are subject to random variation resulting in shifts in the mean test values. Continuous monitoring of assays using control charts will alert the interpreter of changes in performance. For this purpose, several charting methods have been developed and implemented. This paper compares the Shewhart and the exponentially weighted moving average (EWMA) control charts with respect to the day to day monitoring of internal quality control samples for the foot and mouth disease solid phase competition enzyme-linked immunosorbent assay. Both chart types are equally sensitive to shifts, but the EWMA method seems to provide the best balance between false rejection and false acceptance. PMID:16642771

  10. Examination of chromogenic and fluorogenic substrates in solid-phase enzyme linked immunosorbent assays (ELISA)

    International Nuclear Information System (INIS)

    Fluorogenic and chromogenic substrates were used in direct and trapping enzyme linked immunosorbent assays for the detection of mouse IgG and foot and mouth disease virus (FMDV). The detection limits for both antigens were compared, using different combinations of enzymes and substrates. Various times and concentrations of chemicals were used to obtain maximum sensitivity for both systems. Similar sensitivities were found using fluorogenic and chromogenic substrates. Tetramethyl benzidine substrate for horse radish peroxidase enzyme conjugates was found to attain the highest sensitivity levels for chromogenic assays (0.12 ng IgG/ml and 1.0 ng/ml FMDV respectively), after 10 min incubation. Of the two fluorogenic enzyme/substrates studied, B-galactosidase was the most sensitive but required extended incubation times (2-3 h) as compared with chromogenic systems. Special microplates for fluoro-immunoassay were compared with conventional microplates and no advantage was found to justify their use. An alkaline phosphatase anti-guinea pig conjugate was used to confirm the equivalence of fluorogenic and chromogenic substrates in terms of sensitivity. A comparison of the amount of signal generated using various concentrations of enzyme in the absence of antigen was made for two different alkaline phosphatase conjugates to obtain theoretical sensitivity limits. One possible advantage of fluorogenic substrates is that high binding ratio can improve the confidence in discrimination of positive results. (author). 3 refs, 6 figs, 5 tabs

  11. Qinshan phase Ⅱ expansion project to minimize solid waste transformation

    International Nuclear Information System (INIS)

    The nuclear power plant in the production and maintenance period usually have a certain amount of radioactive waste, according to the physical state of these wastes, it can be divided into radioactive waste gas, radioactive waste water and solid waste. Radioactive waste gas and water, treated by the waste treatment system, and the corresponding facilities for filtration, purification. compression, storage to meet discharging requirements, discharge to the environment finally. As for solid radioactive waste, common solution in nuclear power plants is to use specially formulated cement to cure and packaged into the barrel, stored in a particular building for naturally decaying. Qinshan NPP have optimized the solid waste treatment process m extension project. As the nuclear power industry prospering, radioactive solid waste generation would increased dramatically,. how to reduce solid waste production volume, how to control the volume of waste bins will become serious issues in future. Qinshan Phase Ⅱ expansion project as 'replica plus improvement' projects, 'solid waste minimization transformation' has received great attention from SEPA (State Environmental Protection Department). (authors)

  12. Pig-MAP, porcine acute phase proteins and standardisation of assays in Europe

    DEFF Research Database (Denmark)

    Alava, M.A.; Gonzalez-Ramon, N.; Heegaard, Peter M. H.;

    1997-01-01

    during the inflammation. In addition to CRP and Hp, a serum alpha(2)-globulin was observed to be the major acute phase (MAP) protein in pigs. Pig-MAP is a new mammalian plasma protein, which is the pig counterpart of a recently cloned human serum protein denominated PK-120 or MRP. Pig-MAP shows promise...

  13. A rapid and robust assay for detection of S-phase cell cycle progression in plant cells and tissues by using ethynyl deoxyuridine

    Directory of Open Access Journals (Sweden)

    Horváth Gábor V

    2010-01-01

    Full Text Available Abstract Background Progress in plant cell cycle research is highly dependent on reliable methods for detection of cells replicating DNA. Frequency of S-phase cells (cells in DNA synthesis phase is a basic parameter in studies on the control of cell division cycle and the developmental events of plant cells. Here we extend the microscopy and flow cytometry applications of the recently developed EdU (5-ethynyl-2'-deoxyuridine-based S-phase assay to various plant species and tissues. We demonstrate that the presented protocols insure the improved preservation of cell and tissue structure and allow significant reduction in assay duration. In comparison with the frequently used detection of bromodeoxyuridine (BrdU and tritiated-thymidine incorporation, this new methodology offers several advantages as we discuss here. Results Applications of EdU-based S-phase assay in microscopy and flow cytometry are presented by using cultured cells of alfalfa, Arabidopsis, grape, maize, rice and tobacco. We present the advantages of EdU assay as compared to BrdU-based replication assay and demonstrate that EdU assay -which does not require plant cell wall digestion or DNA denaturation steps, offers reduced assay duration and better preservation of cellular, nuclear and chromosomal morphologies. We have also shown that fast and efficient EdU assay can also be an efficient tool for dual parameter flow cytometry analysis and for quantitative assessment of replication in thick root samples of rice. Conclusions In plant cell cycle studies, EdU-based S-phase detection offers a superior alternative to the existing S-phase assays. EdU method is reliable, versatile, fast, simple and non-radioactive and it can be readily applied to many different plant systems.

  14. Cyprus natural analogue project (CNAP). Phase III final report

    International Nuclear Information System (INIS)

    The CNAP Phase III project was carried out following identification of the requirement to support ongoing laboratory and modelling efforts on the potential reaction of the bentonite buffer with cementitious leachates in the repository EBS. Although it is known that the higher pH (12.5 to 13) leachates from OPC cement will degrade bentonite, it is unclear if this will also be the case for the lower pH (10 to 11) leachates typical of low alkali cements. Ongoing laboratory and URL programmes which are currently investigating this face the obstacle of slow kinetics and the production of short-lived metastable phases, meaning obtaining unambiguous results may take decades. This is exacerbated by the limitations of the thermodynamic databases for minerals of interest to models of bentonite/low alkali cement leachate reaction. It was therefore decided to implement a focussed NA study on bentonite/low alkali cement leachate reaction to provide indications of likely long-term reaction products and reaction pathways to provide feedback on the existing short-term investigations noted above and to ascertain if any critical path R and D needs to be instigated now. The results of the analyses presented here suggest that there has been very limited alkaline groundwater reaction with the bentonite. This is generally supported by both the geomorphological evidence and the natural decay series data which imply groundwater groundwater/rock interaction in the last 105 a. When integrated with the novel data currently being produced in the BIGRAD project, the CNAP data tend to indicate that any long-term bentonite reaction in low alkali cement leachates is minimal. (orig.)

  15. Cyprus natural analogue project (CNAP). Phase III final report

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W.R. [Bedrock Geosciences, Auenstein (Switzerland); Milodowski, A.E. [British Geological Survey, Keyworth (United Kingdom); Pitty, A.F. [Pitty (EIA) Consulting, Norwich (United Kingdom)] (eds.)

    2012-01-15

    The CNAP Phase III project was carried out following identification of the requirement to support ongoing laboratory and modelling efforts on the potential reaction of the bentonite buffer with cementitious leachates in the repository EBS. Although it is known that the higher pH (12.5 to 13) leachates from OPC cement will degrade bentonite, it is unclear if this will also be the case for the lower pH (10 to 11) leachates typical of low alkali cements. Ongoing laboratory and URL programmes which are currently investigating this face the obstacle of slow kinetics and the production of short-lived metastable phases, meaning obtaining unambiguous results may take decades. This is exacerbated by the limitations of the thermodynamic databases for minerals of interest to models of bentonite/low alkali cement leachate reaction. It was therefore decided to implement a focussed NA study on bentonite/low alkali cement leachate reaction to provide indications of likely long-term reaction products and reaction pathways to provide feedback on the existing short-term investigations noted above and to ascertain if any critical path R and D needs to be instigated now. The results of the analyses presented here suggest that there has been very limited alkaline groundwater reaction with the bentonite. This is generally supported by both the geomorphological evidence and the natural decay series data which imply groundwater groundwater/rock interaction in the last 10{sup 5} a. When integrated with the novel data currently being produced in the BIGRAD project, the CNAP data tend to indicate that any long-term bentonite reaction in low alkali cement leachates is minimal. (orig.)

  16. Spectral-domain optical coherence phase microscopy for label-free multiplexed protein microarray assay

    OpenAIRE

    Joo, Chulmin; Özkumur, Emre; Ünlü, M. Selim; de Boer, Johannes F.

    2009-01-01

    Quantitative measurement of affinities and kinetics of various biomolecular interactions such as protein-protein, protein-DNA and receptor-ligand is central to our understanding of basic molecular and cellular functions and is useful for therapeutic evaluation. Here, we describe a laser-scanning quantitative imaging method, referred to as spectral-domain optical coherence phase microscopy, as an optical platform for label-free detection of biomolecular interactions. The instrument is based on...

  17. TWRS phase 1 infrastructure project (W-519) characterization

    International Nuclear Information System (INIS)

    In order to treat the mixed radioactive and hazardous waste stored in 177 underground tanks, the Tank Waste Remediation System (TWRS) program is developing a 'demonstration' site for treatment and immobilization of these wastes by a private contractor. Project W-519 is providing the infrastructure support to this site by developing the designs and emplacing required pipelines, roads, electrical, etc. In support of the TWRS Phase 1 Infrastructure Project (W-519) Characterization, Numatec Hanford Corporation (NHC) contracted with Waste Management Federal Services, Inc., Northwest Operations (WMNW) to investigate a number of locations in and just outside the 200 East Area eastern fenceline boundary. These areas consisted of known or suspected waste lines or waste sites that could potentially impact the construction and emplacement of the proposed facility improvements, including waterlines and roads. These sites were all located subsurface and sugaring would be required to obtain sample material from the desired depth. The soils would then be sampled and submitted to the laboratory for analysis of radioactivity

  18. Recovery Efficiency Test Project Phase 2 activity report, Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Salamy, S.P.; Locke, C.D.

    1989-02-01

    The purpose of Phase II operations of the Recovery Efficiency Test Project is to enhance the natural production of the well and evaluate the relative improvement as a function of the type of stimulation conducted. Another purpose is to compare the stimulated production performance of the horizontal well with vertical wells in the field. The objectives considered for Phase II operations and plans were: (1) Develop a rationale for a systematic approach to designing stimulations for the well. (2) Conduct a series of stimulations designed to optimize the fluids, injection rates, proppant volumes and general approach to stimulating a horizontal well with similar geologic conditions. (3) Develop and test a method or methods for determining the geometry of stimulation-induced fractures. (4) Conduct tests and analyze the results to determine the efficiency of stimulation operations. The technical approach pursued in developing plans to accomplish three objectives was to: (1) Review the data needs for all objectives and obtain that data first. (2) Identify the operating geologic, geomechanical, and reservoir parameters that need additional clarification or definition. (3) Investigate existing models which could be used to plan or evaluate stimulation on the well and the reservoir. (4) Plan for analysis and verification of models and approaches.

  19. Development of magnetic solid phase immunoradiometric assay for thyroid stimulating hormone (TSH)

    International Nuclear Information System (INIS)

    Thyroid-stimulating homone (SH), or thyrotropin, is a glycoprotein with a molecular weight of about 28.000 secreted by the pituitary gland. TSH is composed of tow subnits of approximately equalsize, called α and β. Other hormones such as luteinizing hormone (LH) and follicle stimulating hormone (FSH), both secerted by the pituitary, and human chorionic gonadotropin (hCG) produced by the placenta, have α subunits virtually identical to that of TSH, but there are important differences in their Β subunits. These differences confer biological specificity on the complete molecules and allow them to be distinguished in immunassays. The TSH magnetic soild phase immunoradiometric technique incorporates two high affinity monoclonal antibodies one of which is labeled with 125I which attached quickly to a unique site on the TSH motecule, while the second monoclonal antibody immobilized onto magnetic cellulose iron oxide particles, linked to other distinct site on the TSH molecule forming a sandwich. In this study the magnetic particles were firstly activated by carbonyl dimedazole then coupled with anti-TSH monoclonal antibodies which then allowedto bind with TSH hormone. The TSH magnetic soild phase immunoradiometric system, will be optimized where the characterization of the system including accuracy, specificity, sensitivity an dcomparative studies by compare the results of the prepared system with that of commericially used system

  20. The Start-Up Phase in a Research and Development Work Project: A Foundation for Development

    Science.gov (United States)

    Postholm, May Britt

    2008-01-01

    The article is based on a research and development work project (R&D project) conducted in a Norwegian lower secondary school. The purpose of the text is to describe the researchers' and teachers' roles during the initial phase of such a project, and what this phase and the close cooperation between the researcher and teachers mean for the…

  1. Phase 1 of the Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    1990-07-20

    For more than 40 years, the US government made plutonium for nuclear weapons at the Hanford Site in southeastern Washington State. Radioactive materials were released to both the air and water from Hanford. People could have been exposed to these materials, called radionuclides. The Hanford Environmental Dose Reconstruction (HEDR) Project is a multi-year scientific study to estimate the radiation doses the public may have received as a results of these releases. The study began in 1988. During the first phase, scientists began to develop and test methods for reconstructing the radiation doses. To do this, scientists found or reconstructed information about the amount and type of radionuclides that were released from Hadford facilities, where they traveled in environment, and how they reached people. Information about the people who could have been exposed was also found or reconstructed. Scientists then developed a computer model that can estimate doses from radiation exposure received many years ago. All the information that had been gathered was fed into the computer model. Then scientists did a test run'' to see whether the model was working properly. As part of its test run,'' scientists asked the computer model to generate two types of preliminary results: amounts of radionuclides in the environment (air, soil, pasture grass, food, and milk) and preliminary doses people could have received from all the routes of radiation exposure, called exposure pathways. Preliminary dose estimates were made for categories of people who shared certain characteristics and for the Phase 1 population as a whole. 26 refs., 48 figs.

  2. Nano-Phase Powder Based Exothermic Braze Repair Technology For RCC Materials Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Phase II project will advance innovative, cost effective and reliable nano-phase exothermic RCC joining processes (ExoBrazeTM) in order to be able to reinforce...

  3. Solid-Phase Contact Assay That Uses a lux-Marked Nitrosomonas europaea Reporter Strain To Estimate Toxicity of Bioavailable Linear Alkylbenzene Sulfonate in Soil

    OpenAIRE

    Brandt, Kristian K.; Pedersen, Anders; Sørensen, Jan

    2002-01-01

    Information about in situ toxicity of the bioavailable pools of adsorptive soil pollutants is a prerequisite for proper ecological risk assessment in contaminated soils. Such toxicity data may be obtained by assays allowing for direct exposure of introduced test microorganisms to the toxicants, as they appear in solid solution equilibria in the natural soil. We describe a novel sensitive solid-phase contact assay for in situ toxicity testing of soil pollutants based on a recombinant biolumine...

  4. Status of the WAND (Waste Assay for Nonradioactive Disposal) project as of July 1997

    International Nuclear Information System (INIS)

    The WAND (Waste Assay for Nonradioactive Disposal) system can scan thought-to-be-clean, low-density waste (mostly paper and plastics) to determine whether the levels of any contaminant radioactivity are low enough to justify their disposal in normal public landfills or similar facilities. Such a screening would allow probably at least half of the large volume of low-density waste now buried at high cost in LANL's Rad Waste Landfill (Area G at Technical Area 54) to be disposed of elsewhere at a much lower cost. The WAND System consists of a well-shielded bank of six 5-in.-diam. phoswich scintillation detectors; a mechanical conveyor system that carries a 12-in.-wide layer of either shredded material or packets of paper sheets beneath the bank of detectors; the electronics needed to process the outputs of the detectors; and a small computer to control the whole system and to perform the data analysis. WAND system minimum detectable activities (MDAs) for point sources range from ∼20 dps for 241Am to approximately 10 times that value for 239Pu, with most other nuclides of interest being between those values, depending upon the emission probabilities of the radiations emitted (usually gamma rays and/or x-rays). The system can also detect beta particles that have energies ≥100 keV, but it is not easy to define an MDA based on beta radiation detection because of the greater absorption of beta particles relative to photons in low Z-materials. The only radioactive nuclides not detectable by the WAND system are pure alpha emitters and very-low-energy beta emitters. At this time, operating procedures and quality assurance procedures are in place and training materials are available to operators. The system is ready to perform useful work; however, it would be both possible and desirable to upgrade the electronic components and the analysis algorithms

  5. Interface control document for tank waste remediation system privatization phase 1 infrastructure support Project W-519

    International Nuclear Information System (INIS)

    This document describes the functional and physical interfaces between the Tank Waste Remediation System (TWRS) Privatization Phase 1 Infrastructure Project W-519 and the various other projects (i.e., Projects W-314, W-464, W-465, and W-520) supporting Phase 1 that will require the allocation of land in and about the Privatization Phase 1 Site and/or interface with the utilities extended by Project W-519. Project W-519 will identify land use allocations and upgrade/extend several utilities in the 200-East Area into the Privatization Phase 1 Site (formerly the Grout Disposal Compound) in preparation for the Privatization Contractors (PC) to construct treatment facilities. The project will upgrade/extend: Roads, Electrical Power, Raw Water (for process and fire suppression), Potable Water, and Liquid Effluent collection. The replacement of an existing Sanitary Sewage treatment system that may be displaced by Phase 1 site preparation activities may also be included

  6. Horonobe URL project. Experience on borehole investigations in surface-based investigation phase

    International Nuclear Information System (INIS)

    JAEA (Japan Atomic Energy Agency) has been conducting the project which is combined with construction of URL (Underground Research Laboratory) on Neogene sedimentary rock in Horonobe-cho, Hokkaido, JAPAN. This project conjugates with the MIU project on crystalline rock in Mizunami-shi, Gifu-prefecture, JAPAN, was started FY1999/2000. The total duration of the project is about twenty years. The project consists of the following three phases; 1) Surface-based investigation phase. 2) Construction phase. 3) Operation phase. This report summarizes the experience for deep borehole investigation in surface based investigation phase, which is the most important investigation in the phase. All the deep borehole investigations had been planed and carried out in taking account of not only technical consideration but also practical and social aspects. Specifically, the report describes the important suggestions derived from the work of the deep borehole investigations. (author)

  7. Code of Conduct for wind-power projects - Phase 3; Code of Conduct fuer windkraftprojekte. Phase 3 Machbarkeit und Strategie

    Energy Technology Data Exchange (ETDEWEB)

    Strub, P. [Pierre Strub, freischaffender Berater, Binningen (Switzerland); Ziegler, Ch. [Inter Act, Basel (Switzerland)

    2008-11-15

    This paper discusses the results of phase three of a project concerning wind-power projects. Feasibility and strategy aspects are examined and discussed. The current state of the wind power market is discussed on the basis of the results of a survey made on the subject. The social acceptance of wind power installations is discussed, whereby the rejection of particular projects is compared with a general lack of acceptance. Requirements placed on such projects and possible solutions are discussed. Finally, the feasibility of setting up a code of conduct in the area of wind-power projects is discussed and the definition of further instruments is examined

  8. The International intraval project. Phase 1 test cases

    International Nuclear Information System (INIS)

    This report contains a description of the test cases adopted in Phase 1 of the international cooperation project INTRAVAL. Seventeen test cases based on bench-scale experiments in laboratory, field tests and natural analogue studies, have been included in the study. The test cases are described in terms of experimental design and types of available data. In addition, some quantitative examples of available data are given as well as references to more extensive documentation of the experiments on which the test cases are based. Fithteen test cases examples are given: 1 Mass transfer through clay by diffusion and advection. 2 Uranium migration in crystalline bore cores, small scale pressure infiltration experiments. 3 Radionuclide migration in single natural fractures in granite. 4 Tracer tests in a deep basalt flow top. 5 Flow and tracer experiment in crystalline rock based on the Stripa 3-D experiment. 6 Tracer experiment in a fracture zone at the Finnsjon research area. 7 Synthetic data base, based on single fracture migration experiments in Grimsel rock laboratory. 8 Natural analogue studies at Pocos de Caldas, Minais Gerais, Brazil. Redox-front and radionuclide movement in an open pit uranium mine. 9 Natural analogue studies at the Koongarra site in the Alligator Rivers area of the Northern Territory, Australia. 10 Large block migration experiments in a block of crystalline rock. 11 Unsaturated flow and transport experiments performed at Las Cruces, New Mexico. 12 Flow and transport experiment in unsaturated fractured rock performed at the Apache Leap Tuff site, Arizona. 13 Experiments in partially saturated tuffaceous rocks performed in the G-tunnel underground facility at the Nevada Test site, USA. 14 Experimental study of brine transport in porous media. 15 Groundwater flow in the vicinity of the Gorleben Salt Dome, Federal Republic of Germany

  9. Final report on the surface-based investigation phase (phase 1) at the Mizunami Underground Research Laboratory project

    International Nuclear Information System (INIS)

    The Mizunami Underground Research Laboratory (MIU) Project is a comprehensive research project investigating the deep underground environment within crystalline rock being conducted by Japan Atomic Energy Agency at Mizunami City in Gifu Prefecture, central Japan and its role is defined in 'Framework for Nuclear Energy Policy' by Japan Atomic Energy Commission. The MIU Project has three overlapping phases: Surface-based Investigation phase (Phase I), Construction phase (Phase II), and Operation phase (Phase III), with a total duration of 20 years. The overall project goals of the MIU Project from Phase I through to Phase III are: 1) to establish techniques for investigation, analysis and assessment of the deep geological environment, and 2) to develop a range of engineering for deep underground application. During Phase I, the overall project goals were supported by Phase I goals. For the overall project goals 1), the Phase I goals were set to construct models of the geological environment from all surface-based investigation results that describe the geological environment prior to excavation and predict excavation response. For the overall project goals 2), the Phase I goals were set to formulate detailed design concepts and a construction plan for the underground facilities. This report summarizes the Phase I investigation which was completed in March 2005. The authors believe this report will make an important milestone, since this report clarifies how the Phase I goals are achieved and evaluate the future issues thereby direct the research which will be conducted during Phase II. With regard to the overall project goals 1), 'To establish techniques for investigation, analysis and assessment of the deep geological environment,' a step-wise investigation was conducted by iterating investigation, interpretation, and assessment, thereby understanding of geologic environment was progressively and effectively improved with progress of investigation. An optimal

  10. Current status of phase II investigations, Mizunami Underground Research Laboratory (MIU) project - 16262

    International Nuclear Information System (INIS)

    The Mizunami Underground Research Laboratory (MIU) Project, a comprehensive research project investigating the deep underground environment in crystalline rock, is being conducted by the Japan Atomic Energy Agency at Mizunami City, Central Japan. The MIU Project is being carried out in three overlapping phases: Surface-based Investigation (Phase I), Construction (Phase II), and Operation (Phase III), with a total duration of 20 years. The overall project goals of the MIU Project from Phase I through to Phase III are: 1) to establish techniques for investigation, analysis and assessment of the deep geological environment, and 2) to develop a range of engineering techniques for deep underground application. Phase I was completed in March 2004, and Phase II investigations associated with the construction of the underground facilities are currently underway. Phase II investigation goals are to evaluate the geological, hydrogeological, hydrogeochemical and rock mechanical models developed in Phase I and to assess changes in the deep geological environment caused by the construction of underground facilities. Geological mapping, borehole investigations for geological, hydrogeological, hydrochemical and rock mechanical studies are being carried out in shafts and research galleries in order to evaluate the models. Long-term monitoring of changes in groundwater chemistry and pressure associated with the construction of the underground facilities continue in and around the MIU site, using existing boreholes and monitoring systems. This report summarizes the current status of the MIU Project on results of the Phase II investigations to date. (authors)

  11. Full-field phase error detection and compensation method for digital phase-shifting fringe projection profilometry

    International Nuclear Information System (INIS)

    Digital fringe projection profilometry is one of the most widely utilized non-contact three-dimensional (3D) profile measurement techniques. The phase error caused by nonlinear gamma of digital projectors and cameras eventually reduces the 3D measurement accuracy. This kind of phase error still cannot be detected directly at present. A novel method is present in this paper not only to measure the phase error straightforwardly but also to extract the full-field error distributions. With the aid of the detected phase error distributions, the full-field look-up tables (LUTs) can be obtained to correct the phase measurement result. A set of experiments to validate our methods has been performed. Experimental results well prove that the full-field phase error distributions have been detected successfully, and after utilizing our phase correction method the phase accuracy is obviously improved. (paper)

  12. Optoelectronic Infrastructure for RF/Optical Phased Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Optoelectronic integrated circuits offer radiation-hard solutions for satellite systems with much improved SWPB (size, weight, power and bandwidth). The phased...

  13. Functional design criteria for project W-252, phase II liquid effluent treatment and disposal. Revision 2

    International Nuclear Information System (INIS)

    This document is the Functional Design Criteria for Project W-252. Project W-252 provides the scope to provide BAT/AKART (best available technology...) to 200 Liquid Effluent Phase II streams (B-Plant). This revision (Rev. 2) incorporates a major descoping of the project. The descoping was done to reflect a combination of budget cutting measures allowed by a less stringent regulatory posture toward the Phase II streams

  14. Mixed Waste Focus Area/Characterization Monitoring Sensor Technology Nondestructive Waste Assay Capability Evaluation Project End-User Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    G. K. Becker; M. E. McIlwain; M. J. Connolly

    1998-11-01

    The Mixed Waste Focus Area (MWFA) in conjunction with the Characterization Monitoring and Sensor Technology (CMST) crosscut program identified the need to objectively evaluate the capability of nondestructive waste assay (NDA) technologies. This was done because of a general lack of NDA technology performance data with respect to a representative cross section of waste form configurations comprising the Department of Energy (DOE) contact-handled alpha contaminated [e.g., transuranic (TRU) waste]. The overall objective of the Capability Evaluation Project (CEP) was to establish a known and unbiased NDA data and information base that can be used to support end-user decisions with regards to technology system selection and to support technology development organizations in identifying technology system deficiencies. The primary performance parameters evaluated in the CEP were measurement bias and relative precision. The performance of a given NDA technology is a direct function of the attributes represented by the waste matrix configuration. Such attributes include matrix density, matrix elemental composition, radionuclidic composition, radionuclide mass loading, and the spatial variation of these components. Analyzing the manner in which bias and precision vary as a function of test sample attribute and NDA technology provides a foundation for deriving performance capability and limitation statements and determines which waste matrix attributes, or combinations of attributes, are compatible or incompatible with existing technologies. The CEP achieved the stated end-user objective. The data indicate that the nondestructive waste assay systems evaluated have a definite capability to perform assay of contact-handled TRU waste packaged in 55-gallon drums. There is, however, a performance envelope where this capability exists, an area near the envelope boundaries where it is questionable, and a realm outside the envelope where the technologies do not perform. Therefore

  15. Mixed Waste Focus Area/Characterization Monitoring Sensor Technology Nondestructive Waste Assay Capability Evaluation Project End-User Summary Report

    International Nuclear Information System (INIS)

    The Mixed Waste Focus Area (MWFA) in conjunction with the Characterization Monitoring and Sensor Technology (CMST) crosscut program identified the need to objectively evaluate the capability of nondestructive waste assay (NDA) technologies. This was done because of a general lack of NDA technology performance data with respect to a representative cross section of waste form configurations comprising the Department of Energy (DOE) contact-handled alpha contaminated [e.g., transuranic (TRU) waste]. The overall objective of the Capability Evaluation Project (CEP) was to establish a known and unbiased NDA data and information base that can be used to support end-user decisions with regards to technology system selection and to support technology development organizations in identifying technology system deficiencies. The primary performance parameters evaluated in the CEP were measurement bias and relative precision. The performance of a given NDA technology is a direct function of the attributes represented by the waste matrix configuration. Such attributes include matrix density, matrix elemental composition, radionuclidic composition, radionuclide mass loading, and the spatial variation of these components. Analyzing the manner in which bias and precision vary as a function of test sample attribute and NDA technology provides a foundation for deriving performance capability and limitation statements and determines which waste matrix attributes, or combinations of attributes, are compatible or incompatible with existing technologies. The CEP achieved the stated end-user objective. The data indicate that the nondestructive waste assay systems evaluated have a definite capability to perform assay of contact-handled TRU waste packaged in 55-gallon drums. There is, however, a performance envelope where this capability exists, an area near the envelope boundaries where it is questionable, and a realm outside the envelope where the technologies do not perform. Therefore

  16. High-throughput Screening of ToxCast™ Phase I Chemicals in a Mouse Embryonic Stem Cell (mESC) Assay Reveals Disruption of Potential Toxicity Pathways

    Science.gov (United States)

    Little information is available regarding the potential for many commercial chemicals to induce developmental toxicity. The mESC Adherent Cell Differentiation and Cytoxicity (ACDC) assay is a high-throughput screen used to close this data gap. Thus, ToxCast™ Phase I chemicals wer...

  17. South Bay Salt Pond Restoration Project : Phase 1 monitoring plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This SBSP Restoration Project Monitoring Plan provides methods to document the effect of restoration on important elements such as mercury uptake, and water and...

  18. Phase Change Material (PCM) Heat Exchanger Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Project has identified two PCM HX concepts that will be designed, developed and demonstrated on-board the International Space Station (ISS):The first heat exchanger...

  19. Advanced Aqueous Phase Catalyst Development using Combinatorial Methods Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The use of combinatorial methods is proposed to rapidly screen catalyst formulations for the advanced development of aqueous phase oxidation catalysts with greater...

  20. Three Phase Resonant DC Power Converter for Ion Thrusters Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Our phase 1 study has revealed many significant benefits of a new class of DC-to-DC power converters with performance that cannot be matched by current flight power...

  1. Scaling of Two-Phase Systems Across Gravity Levels Project

    Data.gov (United States)

    National Aeronautics and Space Administration — There is a defined need for long term earth based testing for the development and deployment of two-phase flow systems in reduced-gravity, including lunar gravity,...

  2. Gravity Independence of Microchannel Two-Phase Flow Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Most of the amassed two-phase flow and heat transfer knowledge comes from experiments conducted in Earth’s gravity. Space missions span varying gravity...

  3. Optoelectronic Infrastructure for RF/Optical Phased Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Optoelectronic integrated holds the key to higher performance, reduced mass and radiation-hard space systems. A special need is increased flexibility of phased...

  4. Implementing Effective Mission Systems Engineering Practices During Early Project Formulation Phases

    Science.gov (United States)

    Moton, Tryshanda

    2016-01-01

    Developing and implementing a plan for a NASA space mission can be a complicated process. The needs, goals, and objectives of any proposed mission or technology must be assessed early in the Project Life Cycle. The key to successful development of a space mission or flight project is the inclusion of systems engineering in early project formulation, namely during Pre-phase A, Phase A, and Phase B of the NASA Project Life Cycle. When a space mission or new technology is in pre-development, or "pre-Formulation", feasibility must be determined based on cost, schedule, and risk. Inclusion of system engineering during project formulation is key because in addition to assessing feasibility, design concepts are developed and alternatives to design concepts are evaluated. Lack of systems engineering involvement early in the project formulation can result in increased risks later in the implementation and operations phases of the project. One proven method for effective systems engineering practice during the pre-Formulation Phase is the use of a mission conceptual design or technology development laboratory, such as the Mission Design Lab (MDL) at NASA's Goddard Space Flight Center (GSFC). This paper will review the engineering process practiced routinely in the MDL for successful mission or project development during the pre-Formulation Phase.

  5. The joint phase-space transformer up-scattering project

    International Nuclear Information System (INIS)

    Full text: Neutrons from a moderating system have a certain phase space density corresponding to the moderator temperature. According to the Liouville Theorem, the phase-space density cannot be changed within a conservative system, but by means of advanced cooling methods. Nevertheless it is possible to change the shape and position of the phase-space element using conservative forces. Phase-space transformation has been used successfully in high-end backscattering instruments, such as the HFBS at NIST. Here the phase-space element is rotated in order to obtain more neutrons in the backscattering energy region, but with a higher beam divergence. Based on the original idea of Schelten and Alefeld, a new kind of phase-space transformation has been proposed: it is to change the position of the phase-space element in order to produce a well defined neutron beam by coherent up-scattering of an UCN gas. It has been shown that this principle could yield to gain factors of hundred and more compared to 'classical' beam generation. The Atominstitut and the Paul Scherrer Institut have joined to design and construct a 'proof of principle'-experiment. The aims of this experiment are to exploit the feasibility as well as the experimental limitations and to validate preceding MC-simulations. Its scalability makes it a solid starting point for future instruments. Employing a sophisticated mechanical system, Stage-2 Potassium intercalated HOPG crystals (d = 8.74 AA) will be moved with velocities up to 250 m/s. The experiment is planned to take place at the PF-2 UCN source at the ILL in the second half of 2007. (author)

  6. Project W-314 phase I environmental permits and approvals plan

    Energy Technology Data Exchange (ETDEWEB)

    TOLLEFSON, K.S.

    1999-02-24

    This document describes the range of environmental actions, including required permits and other agency approvals, for Project W-314 activities in the Hanford Site's Tank Waste Remediation System. This document outlines alternative approaches to satisfying applicable environmental standards, and describes selected strategies for acquiring permits and other approvals needed for waste feed delivery to proceed. This document also includes estimated costs and schedule to obtain the required permits and approvals based on the selected strategy. It also provides estimated costs for environmental support during design and construction based on the preliminary project schedule provided.

  7. Project W-314 phase I environmental permits and approvals plan

    International Nuclear Information System (INIS)

    This document describes the range of environmental actions, including required permits and other agency approvals, for Project W-314 activities in the Hanford Site's Tank Waste Remediation System. This document outlines alternative approaches to satisfying applicable environmental standards, and describes selected strategies for acquiring permits and other approvals needed for waste feed delivery to proceed. This document also includes estimated costs and schedule to obtain the required permits and approvals based on the selected strategy. It also provides estimated costs for environmental support during design and construction based on the preliminary project schedule provided

  8. Quantum Dynamics in Phase Space using Projected von Neumann Bases.

    Science.gov (United States)

    Machnes, Shai; Assémat, Elie; Larsson, Henrik R; Tannor, David J

    2016-05-19

    We describe the mathematical underpinnings of the biorthogonal von Neumann method for quantum mechanical simulations (PvB). In particular, we present a detailed discussion of the important issue of nonorthogonal projection onto subspaces of biorthogonal bases, and how this differs from orthogonal projection. We present various representations of the Schrödinger equation in the reduced basis and discuss their relative merits. We conclude with illustrative examples and a discussion of the outlook and challenges ahead for the PvB representation. PMID:26977715

  9. Phase II: Final Report. Northern New Mexico Energy Education Project.

    Science.gov (United States)

    New Mexico Highlands Univ., Las Vegas.

    Objectives of the Northern New Mexico Energy Education Project were to: (1) improve teachers' knowledge of energy-related subject matter and energy-related educational materials; (2) develop continuing communication and cooperation between elementary and junior high staffs and the university on energy-related matters; and (3) provide follow-up…

  10. IMPROVING KNOWLEDGE CAPTURE DURING CONCEPTUAL DESIGN PHASE OF BUILDING PROJECTS

    OpenAIRE

    POURZOLFAGHAR, ZOHREH

    2010-01-01

    Incomplete knowledge flow between architects and mechanical/electrical engineers engenders large expense and untimely delivery of building projects. It is essential to consider mechanical/electrical requirements from the early stages of design; and many experienced architects acknowledge this knowledge entities and the necessity for considering them at the right time. Therefore, inefficient knowledge flow among professionals during architectural conceptual design is emphasiz...

  11. Hormone assay

    International Nuclear Information System (INIS)

    An improved radioimmunoassay is described for measuring total triiodothyronine or total thyroxine levels in a sample of serum containing free endogenous thyroid hormone and endogenous thyroid hormone bound to thyroid hormone binding protein. The thyroid hormone is released from the protein by adding hydrochloric acid to the serum. The pH of the separated thyroid hormone and thyroid hormone binding protein is raised in the absence of a blocking agent without interference from the endogenous protein. 125I-labelled thyroid hormone and thyroid hormone antibodies are added to the mixture, allowing the labelled and unlabelled thyroid hormone and the thyroid hormone antibody to bind competitively. This results in free thyroid hormone being separated from antibody bound thyroid hormone and thus the unknown quantity of thyroid hormone may be determined. A thyroid hormone test assay kit is described for this radioimmunoassay. It provides a 'single tube' assay which does not require blocking agents for endogenous protein interference nor an external solid phase sorption step for the separation of bound and free hormone after the competitive binding step; it also requires a minimum number of manipulative steps. Examples of the assay are given to illustrate the reproducibility, linearity and specificity of the assay. (UK)

  12. 105-B Reactor museum Phase 2 project supplement cost estimate

    International Nuclear Information System (INIS)

    This document serves as a supplement to BHI-0134, 105-B Reactor Museum Feasibility Assessment. The Phase 2 105-B Reactor assessment was performed to provide a basis for identifying and mitigating the hazards in specific areas of the B Reactor facility to support public tours

  13. Educational Services Master Plan Project. Phase I: Information.

    Science.gov (United States)

    Adams, Suzanne; And Others

    This document reports the findings of four task forces involved in the first phase of master planning for the Peralta Community College District. Task Force I concerned itself with population, revenue, and enrollment trends. Peralta has had financial difficulty because of inflation and a general decline in assessed valuation per ADA. After the…

  14. Phase Change Permeation Technology for Environmental Control & Life Support Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This project will explore a recent advancement in Phase Change Permeation™ technology to enable improved (1) water recovery from urine/brine for Environmental...

  15. The quantitation of biotinylated compounds by a solid-phase assay using a 125I-labelled biotin derivative

    International Nuclear Information System (INIS)

    The biotin analogue biotinylglycyltyrosine has been synthesized and labelled to a specific activity of 2000 Ci/mmol with 125I. This analogue has been used in conjunction with immobilized streptavidin in an assay which detects as little as 1 fmol biotin or biotinylated molecules in solution. The determination of biotinylated insulin in a tissue extract and the quantitation of a transcription assay are given as examples. (Auth.)

  16. CEC project Mirage - Second phase on migration of radionuclides in the geosphere

    International Nuclear Information System (INIS)

    A second phase of the Community coordinated project Mirage (migration of radionuclides in the geosphere) was launched in 1986. The present report brings together reviews of work done in the four research areas of this phase for 1988, and therefore constitues an update of the previous report, ref. EUR 11589. This project is part of the CEC R and D programme on radioactive waste management (1985-89)

  17. Program for the Stripa project phase 3, 1986-1991

    International Nuclear Information System (INIS)

    In June 1985, the Joint Technical Committee agreed to proceed with the planning required for the initiation of a Phase 3. The following general objectives of a third phase were agreed upon: To integrate various site characterization techniques and methods of analysis for the prediction and validation of ground-water flow and nuclide transport in an unexplored volume of Stripa granite and to demonstrate and verify the use of different materials and techniques for sealing ground-water flow paths in the Stripa granite. A schedule for the solicitation review of proposals was established. The general areas of investigations were defined as: Site characterization and validation; improvement of site assessment methods and concepts; sealing of fractured rock. (orig./HP)

  18. Fish tracking technology development. Phase 1 project definition desk study

    OpenAIRE

    Moore, A.; Potter, E.C.E.

    1994-01-01

    The document reports on Phase 1 of a definition study to appraise the options to develop fish tracking equipment, in particular tags and data logging systems in order to improve the efficiency of the Environment Agency's tracking studies and to obtain a greater understanding of fish biology. Covered in this report are radio telemetry, audio telemetry, High Resolution Position Fixing, data storage and archival tags and other fish tracking systems such as biosonics.

  19. The FAZIA project in Europe: R and D phase

    International Nuclear Information System (INIS)

    The goal of the FAZIA Collaboration is the design of a new-generation 4π detector array for heavy-ion collisions with radioactive beams. This article summarizes the main results of the R and D phase, devoted to the search for significant improvements of the techniques for charge and mass identification of reaction products. This was obtained by means of a systematic study of the basic detection module, consisting of two transmission-mounted silicon detectors followed by a CsI(Tl) scintillator. Significant improvements in ΔE-E and pulse-shape techniques were obtained by controlling the doping homogeneity and the cutting angles of silicon and by putting severe constraints on thickness uniformity. Purposely designed digital electronics contributed to identification quality. The issue of possible degradation related to radiation damage of silicon was also addressed. The experimental activity was accompanied by studies on the physics governing signal evolution in silicon. The good identification quality obtained with the prototypes during the R and D phase, allowed us to investigate also some aspects of isospin physics, namely isospin transport and odd-even staggering. Now, after the conclusion of the R and D period, the FAZIA Collaboration has entered the demonstrator phase, with the aim of verifying the applicability of the devised solutions for the realization of a larger-scale experimental set-up. (orig.)

  20. The FAZIA project in Europe: R and D phase

    Energy Technology Data Exchange (ETDEWEB)

    Bougault, R.; Le Neindre, N.; Bougard, B.; Desrues, P.; Legouee, E.; Lopez, O.; Merrer, Y.; Pain, C.; Vient, E. [Universite de Caen, CNRS-IN2P3, LPC Caen, ENSICAEN, Caen cedex (France); Poggi, G.; Barlini, S.; Pasquali, G.; Bardelli, L.; Bini, M.; Carboni, S.; Pastore, G.; Stefanini, A.A.; Valdre, S. [Universita di Firenze, Dipartimento di Fisica, Sesto Fiorentino (Italy); Sezione di Firenze, INFN, Sesto Fiorentino (Italy); Borderie, B.; Ademard, G.; Barbey, S.; Brulin, G.; Edelbruck, P.; Hamrita, H.; Huss, C.; Lavergne, L.; Rauly, E.; Rivet, M.F.; Salomon, F.; Seredov, V.; Wanlin, E. [Universite Paris-Sud 11, Institut de Physique Nucleaire, CNRS/IN2P3, Orsay cedex (France); Casini, G.; Piantelli, S.; Olmi, A.; Tobia, G. [Sezione di Firenze, INFN, Sesto Fiorentino (Italy); Chbihi, A.; Boisjoli, M.; Bonnet, E.; Frankland, J.D.; Gruyer, D.; Marini, P.; Spitaels, C. [CEA/DSM-CNRS/IN2P3, GANIL, Caen cedex (France); Parlog, M. [Universite de Caen, CNRS-IN2P3, LPC Caen, ENSICAEN, Caen cedex (France); Horia Hulubei National Institute of Physics and Nuclear Engineering (IFIN-HH), Bucharest Magurele (Romania); Sosin, Z.; Kajetanowicz, M.; Kozik, T.; Kulig, P.; Palka, M.; Sierpowski, D.; Twarog, T.; Wieloch, A. [Institute of Physics, Jagiellonian University, Krakow (Poland); Alba, R.; Maiolino, C.; Santonocito, D. [Laboratori Nazionali del Sud, INFN, Catania (Italy); Anastasio, A.; Boiano, A.; Cassese, C.; Cassese, F.; D' Aquino, B.; Di Meo, P.; Masone, V.; Meoli, A.; Ordine, A.; Paduano, G.; Passeggio, G.; Pontoriere, G.; Rocco, R.; Roscilli, L.; Tortone, G.; Vanzanella, A.; Vanzanella, E.; Vitiello, G. [Complesso Universitario di Monte S. Angelo, Napoli (Italy); INFN - Sezione di Napoli, Napoli (Italy); Borcea, R.; Ciolacu, L.; Cruceru, I.; Cruceru, M.; Negoita, F.; Petcu, M.; Petrascu, H. [Horia Hulubei National Institute of Physics and Nuclear Engineering (IFIN-HH), Bucharest Magurele (Romania); Bruno, M.; Morelli, L. [INFN, Sezione di Bologna (Italy); Dipartimento di Fisica ed Astronomia, Universita di Bologna, Bologna (Italy); Cinausero, M.; Gramegna, F.; Marchi, T. [LNL Legnaro, INFN, Legnaro (Italy); De Fazio, B. [Complesso Universitario di Monte S. Angelo, Dipartimento di Fisica, Universita di Napoli ' ' Federico II' ' , Napoli (Italy); Degerlier, M. [Nevsehir Haci Bektas University, Science and Art Faculty, Physics Department, Nevsehir (Turkey); Duenas, J.A.; Martel, I. [FCCEE Universidad de Huelva, Departamento de Fisica Aplicada, Huelva (Spain); Energico, S. [Complesso Universitario di Monte S. Angelo, Istituto SPIN - CNR, Napoli (Italy); Falorsi, M.; Scarlini, E. [Universita di Firenze, Dipartimento di Fisica, Sesto Fiorentino (Italy); Galichet, E. [Universite Paris-Sud 11, Institut de Physique Nucleaire, CNRS/IN2P3, Orsay cedex (France); Conservatoire National des Arts et Metiers, Paris (France); Gasior, K.; Grzeszczuk, A.; Zipper, W. [University of Silesia, August Chellkowski Institute of Physics, Katowice (Poland); Giordano, R. [Complesso Universitario di Monte S. Angelo, Napoli (Italy); INFN - Sezione di Napoli, Napoli (Italy); Universita di Napoli ' ' Federico II' ' , Dipartimento di Informatica e Sistemistica, Napoli (Italy); Guerzoni, M.; Serra, S. [Sezione di Bologna, INFN, Bologna (Italy); Korcyl, K.; Lukasik, J.; Pawlowski, P. [Institute of Nuclear Physics PAN, Krakow (Poland); Kordyasz, A.; Piasecki, E. [University of Warsaw, Heavy Ion Laboratory, Warsaw (Poland); Rosato, E.; Spadaccini, G.; Vigilante, M. [Complesso Universitario di Monte S. Angelo, Napoli (Italy); INFN - Sezione di Napoli, Napoli (Italy); Complesso Universitario di Monte S. Angelo, Dipartimento di Fisica, Universita di Napoli ' ' Federico II' ' , Napoli (Italy); Collaboration: The FAZIA Collaboration

    2014-02-15

    The goal of the FAZIA Collaboration is the design of a new-generation 4π detector array for heavy-ion collisions with radioactive beams. This article summarizes the main results of the R and D phase, devoted to the search for significant improvements of the techniques for charge and mass identification of reaction products. This was obtained by means of a systematic study of the basic detection module, consisting of two transmission-mounted silicon detectors followed by a CsI(Tl) scintillator. Significant improvements in ΔE-E and pulse-shape techniques were obtained by controlling the doping homogeneity and the cutting angles of silicon and by putting severe constraints on thickness uniformity. Purposely designed digital electronics contributed to identification quality. The issue of possible degradation related to radiation damage of silicon was also addressed. The experimental activity was accompanied by studies on the physics governing signal evolution in silicon. The good identification quality obtained with the prototypes during the R and D phase, allowed us to investigate also some aspects of isospin physics, namely isospin transport and odd-even staggering. Now, after the conclusion of the R and D period, the FAZIA Collaboration has entered the demonstrator phase, with the aim of verifying the applicability of the devised solutions for the realization of a larger-scale experimental set-up. (orig.)

  1. Code of Conduct for wind-power projects - Phases 1 and 2

    International Nuclear Information System (INIS)

    This paper discusses the results of the first two phases of a project concerning wind-power projects. The paper deals with the results of a system analysis, takes a look at lessons learned and presents an appraisal of existing instruments. A system-analysis of wind-power projects is presented with emphasis on social factors and the role of stakeholders. The success factors concerning social acceptance of wind-power projects and their special characteristics are discussed. Lessons learned are examined. Instruments for the sustainable implementation of projects are looked at, in particular with a focus on social acceptance

  2. 76 FR 55947 - Industrial Relations Promotion Project, Phase II in Vietnam

    Science.gov (United States)

    2011-09-09

    ... of the Secretary Industrial Relations Promotion Project, Phase II in Vietnam AGENCY: Bureau of... implementing a program to strengthen compliance with international labor standards in Vietnam, focusing... has the recognized authority and capacity to fulfill the intent of the IRRP Phase II in Vietnam....

  3. Interfacial Chemistry and the Design of Solid-Phase Nucleic Acid Hybridization Assays Using Immobilized Quantum Dots as Donors in Fluorescence Resonance Energy Transfer

    OpenAIRE

    Ulrich J. Krull; W. Russ Algar

    2011-01-01

    The use of quantum dots (QDs) as donors in fluorescence resonance energy transfer (FRET) offer several advantages for the development of multiplexed solid-phase QD-FRET nucleic acid hybridization assays. Designs for multiplexing have been demonstrated, but important challenges remain in the optimization of these systems. In this work, we identify several strategies based on the design of interfacial chemistry for improving sensitivity, obtaining lower limits of detection (LOD) and enabling th...

  4. Analysis of Benzo[a]pyrene in Vegetable Oils Using Molecularly Imprinted Solid Phase Extraction (MISPE) Coupled with Enzyme-Linked Immunosorbent Assay (ELISA)

    OpenAIRE

    Michael Pschenitza; Rudolf Hackenberg; Reinhard Niessner; Dietmar Knopp

    2014-01-01

    This paper describes the development of a molecularly imprinted polymer-based solid phase extraction (MISPE) method coupled with enzyme-linked immunosorbent assay (ELISA) for determination of the PAH benzo[a]pyrene (B[a]P) in vegetable oils. Different molecularly imprinted polymers (MIPs) were prepared using non-covalent 4-vinylpyridine/divinylbenzene co-polymerization at different ratios and dichloromethane as porogen. Imprinting was done with a template mixture of phenanthrene and pyrene ...

  5. Systems engineering aspects to installation of the phased multi-year LANSCE-refurbishment project

    Energy Technology Data Exchange (ETDEWEB)

    Pieck, Martin [Los Alamos National Laboratory; Erickson, John E [Los Alamos National Laboratory; Gulley, Mark S [Los Alamos National Laboratory; Jones, Kevin W [Los Alamos National Laboratory; Rybarcyk, Larry J [Los Alamos National Laboratory

    2009-01-01

    The LANSCE Refurbishment Project (LANSCE-R) is a phased, multiyear project. The project is scheduled to start refurbishment in the 2nd quarter of fiscal year 2011. Closeout will occur during the 4th quarter of FY2016. During the LANSCE-R project, installation of project components must be scheduled during six annual 6-month maintenance-outages and not conflict with annual LANSCE operational commitments to its user facilities. The project and operations schedules must be synchronized carefully. Therefore, the scheduled maintenance outages, functional testing (with beam off, by primarily project personnel) and commissioning (with beam on, by primarily Accelerator Operation Technology (AOT) personnel) must be managed to accommodate operation. Active and effective coordination and communication between the project and AOT personnel must be encouraged to identify, as early as possible, any operational issues. This paper will report on the systems engineering approach to the integration and control of engineering activities.

  6. Final Report for the ADMX Phase 2a Project at the University of Washington

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, Leslie J. [Univ. of Washington, Seattle, WA (United States). Dept. of Physics

    2015-08-22

    This is a final report of the ADMX Phase 2a program. This program is a project allowing for a sensitive axion dark-matter axion search at higher axion masses. The Phase 2a program also prepares the project for lower temperature anticipated in later operations. The Phase 2a program includes sensitive data-taking operations at two cavity modes, TM010 and TM020, allowing for faster data-taking operations and extending the search to higher and plausible dark-matter axion masses.

  7. Geothermal project in Brig-Glis - Final report for phase 1 and further work in phase 2; Geothermieprojekt Brig-Glis, Abschlussbericht Phase 1 und weiteres Vorgehen Phase 2 - Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Buser, M. [Creato, Ennetbaden (Switzerland); Paris, U. [SRP Schneller Ritz und Partner AG, Brig (Switzerland); Bianchetti, G. [AlpGeo Sarl, Sierre (Switzerland); Jacquod, J. [Norbert SA, Martigny (Switzerland); Kreuter, H. [GeoThermal Engineering GmbH, Geo-T, Karlsruhe (Germany); Surbeck, H. [Centre of Hydrogeology, CHYN, University of Neuchatel, Neuchatel (Switzerland); Vuataz, F.-D. [Centre de Recherche en Geothermie, CREGE, Neuchatel (Switzerland)

    2008-05-15

    This final report for Swiss Federal Office of Energy (SFOE) presents the work done in phase 1 of the project and discusses further work planned for the second phase of this project. The geothermal borehole is to be driven down at the Brigerbad thermal spa in Switzerland and is to use the artesian waters found under the Rhone valley. The first phase of the project is reported on and the results obtained are analysed. Temperatures and conductivity of the waters found at various depths are commented on. The planning of the second and third phases is discussed and organisational improvements are noted.

  8. Final report on the surface-based investigation (phase 1) at the Mizunami Underground Laboratory project

    International Nuclear Information System (INIS)

    The Mizunami Underground Laboratory (MIU) Project is a comprehensive research project investigating the deep underground environment within crystalline rock being conducted by Japan Atomic Energy Agency at Mizunami City in Gifu Prefecture, central Japan and its role is defined in 'Framework for Nuclear Energy Policy' by Japan Atomic Energy Commission. The MIU Project has three overlapping phases: Surface-based Investigation phase (Phase I), Construction phase (Phase II), and Operation phase (Phase III), with a total duration of 20 years. The overall project goals of the MIU Project from Phase I through to Phase III are: 1) to establish techniques for investigation, analysis and assessment of the deep geological environment, and 2) to develop a range of engineering for deep underground application. During Phase I, the overall project goals were supported by Phase I goals. For the overall project goals 1), the Phase I goals were set to construct models of the geological environment from all surface-based investigation results that describe the geological environment prior to excavation and predict excavation response. For the overall project goals 2), the Phase I goals were set to formulate detailed design concepts and a construction plan for the underground facilities. This report summarizes the Phase I investigation which was completed in March 2005. The authors believe this report will make an important milestone, since this report clarifies how the Phase I goals are achieved and evaluate the future issues thereby direct the research which will be conducted during Phase II. With regard to the overall project goals 1), 'To establish techniques for investigation, analysis and assessment of the deep geological environment,' a step-wise investigation was conducted by iterating investigation, interpretation, and assessment, thereby understanding of geologic environment was progressively and effectively improved with progress of investigation. An optimal procedure from

  9. Local random phase approximation with projected oscillator orbitals

    CERN Document Server

    Mussard, Bastien

    2015-01-01

    An approximation to the many-body London dispersion energy in molecular systems is expressed as a functional of the occupied orbitals only. The method is based on the local-RPA theory. The occupied orbitals are localized molecular orbitals and the virtual space is described by projected oscillator orbitals, i.e. functions obtained by multiplying occupied localized orbitals with solid spherical harmonic polynomials having their origin at the orbital centroids. Since we are interested in the long-range part of the correlation energy, responsible for dispersion forces, the electron repulsion is approximated by its multipolar expansion. This procedure leads to a fully non-empirical long-range correlation energy expression. Molecular dispersion coefficients calculated from determinant wave functions obtained by a range-separated hybrid method reproduce experimental values with less than 15% error.

  10. International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials.

    Science.gov (United States)

    Galipeau, Jacques; Krampera, Mauro; Barrett, John; Dazzi, Francesco; Deans, Robert J; DeBruijn, Joost; Dominici, Massimo; Fibbe, Willem E; Gee, Adrian P; Gimble, Jeffery M; Hematti, Peiman; Koh, Mickey B C; LeBlanc, Katarina; Martin, Ivan; McNiece, Ian K; Mendicino, Michael; Oh, Steve; Ortiz, Luis; Phinney, Donald G; Planat, Valerie; Shi, Yufang; Stroncek, David F; Viswanathan, Sowmya; Weiss, Daniel J; Sensebe, Luc

    2016-02-01

    Mesenchymal stromal cells (MSCs) as a pharmaceutical for ailments characterized by pathogenic autoimmune, alloimmune and inflammatory processes now cover the spectrum of early- to late-phase clinical trials in both industry and academic sponsored studies. There is a broad consensus that despite different tissue sourcing and varied culture expansion protocols, human MSC-like cell products likely share fundamental mechanisms of action mediating their anti-inflammatory and tissue repair functionalities. Identification of functional markers of potency and reduction to practice of standardized, easily deployable methods of measurements of such would benefit the field. This would satisfy both mechanistic research as well as development of release potency assays to meet Regulatory Authority requirements for conduct of advanced clinical studies and their eventual registration. In response to this unmet need, the International Society for Cellular Therapy (ISCT) addressed the issue at an international workshop in May 2015 as part of the 21st ISCT annual meeting in Las Vegas. The scope of the workshop was focused on discussing potency assays germane to immunomodulation by MSC-like products in clinical indications targeting immune disorders. We here provide consensus perspective arising from this forum. We propose that focused analysis of selected MSC markers robustly deployed by in vitro licensing and metricized with a matrix of assays should be responsive to requirements from Regulatory Authorities. Workshop participants identified three preferred analytic methods that could inform a matrix assay approach: quantitative RNA analysis of selected gene products; flow cytometry analysis of functionally relevant surface markers and protein-based assay of secretome. We also advocate that potency assays acceptable to the Regulatory Authorities be rendered publicly accessible in an "open-access" manner, such as through publication or database collection. PMID:26724220

  11. Cyprus natural analogue project (CNAP). Phase II Final Report

    International Nuclear Information System (INIS)

    Due to the extremely slow kinetics of bentonite reaction in low alkali cement leachates, natural analogues would appear to be the only viable method of studying bentonite reaction. As a result of a review of the available literature, several sites in Cyprus were selected as particularly promising for this purpose. This report presents the results of two short field campaigns in Cyprus in November/December, 2008 and February, 2009. The main aim of these campaigns was to establish if appropriate sites existed for a natural analogue study of bentonite-low alkali cement leachate reaction. Focus is on mineralogical changes and not changes in physical properties (such as porosity and permeability) of bentonite as the industrially-processed bentonite used in a repository will be completely different in terms of its engineering and hydrogeological properties to the unprocessed natural bentonite or analogue smectite-rich materials. The first campaign was in the form of a reconnaissance study to identify sites of likely interest and the second, follow-up, campaign focussed on obtaining preliminary groundwater and solid phase (bentonites/clay-rich sediments/altered igneous rocks/soils) samples which would allow a more detailed assessment of several of the potential sites. A large amount of information was collected during these short field campaigns and subsequent laboratory analysis of the collected samples so, to keep the main report down to a digestible size, much of the supporting information has been collated in seven appendices. These include full details of all 30 sites visited during both campaigns along with sample details, information on the analytical techniques, the analytical raw data and numerous photographs of the sites. The intention is that this report will provide full supporting information for a potential Phase III and a detailed database for our colleagues at the Geological Survey Department (GSD) in Cyprus. Consequently, all the information acquired

  12. National Biomedical Tracer Facility (NBTF). Project definition study: Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Lagunas-Solar, M.C.

    1995-02-15

    This report describes a five-year plan for the construction and commissioning of a reliable and versatile NBTF facility for the production of high-quality, high-yield radioisotopes for research, biomedical, and industrial applications. The report is organized in nine sections providing, in consecutive order, responses to the nine questions posed by the U.S. Department of Energy in its solicitation for the NBTF Project Definition Study. In order to preserve direct correspondence (e.g., Sec. 3 = 3rd item), this Introduction is numbered {open_quotes}0.{close_quotes} Accelerator and facility designs are covered in Section 1 (Accelerator Design) and Section 2 (Facility Design). Preliminary estimates of capital costs are detailed in Section 3 (Design and Construction Costs). Full licensing requirements, including federal, state, and local ordinances, are discussed in Section 4 (Permits). A plan for the management of hazardous materials to be generated by NBTF is presented in Section 5 (Waste Management). An evaluation of NBTF`s economic viability and its potential market impact is detailed in Section 6(Business Plan), and is complemented by the plans in Section 7 (Operating Plan) and Section 8 (Radioisotope Plan). Finally, a plan for NBTF`s research, education, and outreach programs is presented in Section 9 (Research and Education Programs).

  13. Small and medium power reactors: project initiation study, Phase 1

    International Nuclear Information System (INIS)

    In conformity with the Agency's promotional role in the peaceful uses of nuclear energy, IAEA has provided, over the past 20 years, assistance to Member States, particularly developing countries, in planning for the introduction of nuclear power plants in the Small and Medium range (SMPR). However these efforts did not produce any significant results in the market introduction of these reactors, due to various factors. In 1983 the Agency launched a new SMPR Project Initiation Study with the objective of surveying the available designs, examining the major factors influencing the decision-making processes in Developing Countries and thereby arriving at an estimate of the potential market. Two questionnaires were used to obtain information from possible suppliers and prospective buyers. The Nuclear Energy Agency of OECD assisted in making a study of the potential market in industrialized countries. The information gained during the study and discussed during a Technical Committee Meeting on SMPRs held in Vienna in March 1985, along with the contribution by OECD-NEA is embodied in the present report

  14. Absolute phase retrieval for defocused fringe projection three-dimensional measurement

    Science.gov (United States)

    Zheng, Dongliang; Da, Feipeng

    2014-02-01

    Defocused fringe projection three-dimensional technique based on pulse-width modulation (PWM) can generate high-quality sinusoidal fringe patterns. It only uses slightly defocused binary structured patterns which can eliminate the gamma problem (i.e. nonlinear response), and the phase error can be significantly reduced. However, when the projector is defocused, it is difficult to retrieve the absolute phase from the wrapped phase. A recently proposed phase coding method is efficient for absolute phase retrieval, but the gamma problem leads this method not so reliable. In this paper, we use the PWM technique to generate fringe patterns for the phase coding method. The gamma problem of the projector can be eliminated, and correct absolute phase can be retrieved. The proposed method only uses two grayscale values (0's and 255's), which can be used for real-time 3D shape measurement. Both simulation and experiment demonstrate the performance of the proposed method.

  15. Trans-Pacific HDR Satellite Communications Experiment Phase-2 Project Plan and Experimental Network

    Science.gov (United States)

    Hsu, Eddie; Kadowaki, Naoto; Yoshimura, Naoko; Takahashi, Takashi; Yoshikawa, Makoto; Bergman, Larry; Bhasin, Kul

    2000-01-01

    The trans-Pacific high data rate (TP-HDR) satellite communications experiment was proposed at the Japan-U.S. Cooperation in Space (JUCS) Program Workshop held in Hawaii in 1993 and remote high definition video post-production was demonstrated as the first phase trial. ATM-based 45 Mbps trans-Pacific link was established in the first phase, and the following experiments with 155 Mbps was planned as the phase 2. This paper describes the experimental network configuration and project plan of TP-HDR experiment phase 2. Additional information is provided in the original.

  16. Phase 2 Rebaseline Report for Tank Farm Restoration and Safe Operations Project W-314

    International Nuclear Information System (INIS)

    Project W-314, (97-D-402) Tank Farm Restoration and Safe Operations is a multi-year, multiphase project established to upgrade selected 200 East and West Area Tank Farms to support the long-term mission of waste storage, retrieval, and transfer for vitrification. Key drivers for these upgrades include the planned timetable for transfer of waste to the privatized vitrification facility, regulatory compliance requirements (i.e., Washington State and Federal Regulations), and the Tri-Party Agreement (TPA). The previous baseline scope for Project W-314 was established based upon tank farm system assessments performed five to six years ago and was reflected in the previous baseline cost estimate, the Accelerated Replanning Estimate, completed in July 1997. The Accelerated Replanning Estimate splits the project into two phases: Phase 1 provides upgrades necessary to assure reliable waste retrieval and transfer to the anticipated vitrification plant. Phase 2 provides upgrades to selected primary and annulus tank farm ventilation systems that are required for compliant waste transfer, as well as other compliance-based upgrades to existing River Protection Project (WP) facilities and systems. The Accelerated Replanning Estimate provided the basis for Baseline Change Request TWR 97-066, which identified Phases 1 and 2 as $95 million and $206.5 million, respectively. Following completion of the Accelerated Replanning Estimate, several changes occurred that prompted a decision to rebaseline Phase 1, and subsequently Phase 2. Paramount among these was the delay in the Privatization schedule (90% case), lessons learned (in the year since the Accelerated Planning Report had been completed), and the adoption of an alternate waste transfer system route. The rebaselined cost of phase 1, $157 million, was substantially higher than the Accelerated Replanning Estimate for a number of reasons more thoroughly discussed in the Phase 1 Rebaseline Report, HNF-3781, January 1999. Since the

  17. Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development

    Directory of Open Access Journals (Sweden)

    Jalal Pourahmad

    2005-01-01

    Full Text Available While drug toxicity (especially hepatotoxicity is the most frequent reason cited for withdrawal of an approved drug, no simple solution exists to adequately predict such adverse events. Simple cytotoxicity assays in HepG2 cells are relatively insensitive to human hepatotoxic drugs in a retrospective analysis of marketed pharmaceuticals. In comparison, a panel of pre-lethal mechanistic cellular assays hold the promise to deliver a more sensitiveapproach to detect endpoint-specific drug toxicities. The panel of assays covered by this review includes steatosis, cholestasis, phospholipidosis, reactive intermediates, mitochondria membrane function, oxidative stress, and drug interactions. In addition, the use of metabolically competent cells or the introduction of major human hepatocytes in these in-vitro studies allow a more complete picture of potential drug side effect. Since inter-individual therapeutic index (TI may differ from patient to patient, the rational use of one or more of these cellular assay and targeted in-vivo exposure data may allow pharmaceutical scientists to select drugcandidates with a higher TI potential in the drug discovery phase.

  18. Interfacial Chemistry and the Design of Solid-Phase Nucleic Acid Hybridization Assays Using Immobilized Quantum Dots as Donors in Fluorescence Resonance Energy Transfer

    Directory of Open Access Journals (Sweden)

    Ulrich J. Krull

    2011-06-01

    Full Text Available The use of quantum dots (QDs as donors in fluorescence resonance energy transfer (FRET offer several advantages for the development of multiplexed solid-phase QD-FRET nucleic acid hybridization assays. Designs for multiplexing have been demonstrated, but important challenges remain in the optimization of these systems. In this work, we identify several strategies based on the design of interfacial chemistry for improving sensitivity, obtaining lower limits of detection (LOD and enabling the regeneration and reuse of solid-phase QD-FRET hybridization assays. FRET-sensitized emission from acceptor dyes associated with hybridization events at immobilized QD donors provides the analytical signal in these assays. The minimization of active sensing area reduces background from QD donor PL and allows the resolution of smaller amounts of acceptor emission, thus lowering the LOD. The association of multiple acceptor dyes with each hybridization event can enhance FRET efficiency, thereby improving sensitivity. Many previous studies have used interfacial protein layers to generate selectivity; however, transient destabilization of these layers is shown to prevent efficient regeneration. To this end, we report a protein-free interfacial chemistry and demonstrate the specific detection of as little as 2 pmol of target, as well as an improved capacity for regeneration.

  19. Project construction and important technical innovation for Qinshan phase III (PHWR) nuclear power plant

    International Nuclear Information System (INIS)

    Qinshan Phase III (PHWR) Nuclear Power Plant, the first commercial heavy water reactor nuclear power plant in China, was the biggest trade project performed between the governments of China and Canada.As the owner, the Third Qinshan Nuclear Power Company (TQNPC) persisted in independent innovation management during the project construction, commissioning and self-dependent operation, efficiently realizing the three controls of the project, i. e. quality control, schedule control and investment control, and persisted in technical improvement on the basis of digestion and absorption of CANDU-6 technology to improve the unit safety and reliability. The project construction practice has helped China's nuclear power project management to becomeprogrammed, computerized,standardized and internationalized management from the existing basis.After completion of the project, with unit safe and steady operation as the prerequisite, TQNPC performed several technical modifications and innovations to continuously improve the unit performance. In the area of staff development, TQNPC paid much attention to cultivation of corporate culture, strengthed staff training and built up a good circulating mechanism with staff training and project construction promoting each other. Further to 'Zero Breakthrough' and a new step forward of locolization successfully realized in Qinshan Nuclear Power Plant and Nuclear Power Qinshan Joint Venture Company, the improvement and developemnt of nuclear power project management level in Qinshan Phase III (PHWR) Nuclear Power Plant provided reference for promotion of nuclear power development in China and standardized management of introducing large imported project. (authors)

  20. When to use the projection assumption and the weak-phase object approximation in phase contrast cryo-EM

    International Nuclear Information System (INIS)

    The projection assumption (PA) and the weak-phase object approximation (WPOA) are commonly used to model image formation in cryo-electron microscopy. For simulating the next step in resolution improvement we show that it is important to revisit these two approximations as well as their limitations. Here we start off by inspecting both approximations separately to derive their respective conditions of applicability. The thick-phase grating approximation (TPGA) imposes less strict conditions on the interaction potential than PA or WPOA and gives comparable exit waves as a multislice calculation. We suggest the ranges of applicability for four models (PA, PA+WPOA, WPOA, and TPGA) given different interaction potentials using exit wave simulations. The conditions of applicability for the models are based on two measures, a worst-case (safest) and an average criterion. This allows us to present a practical guideline for when to use each image formation model depending on the spatial frequency, thickness and strength of the interaction potential of a macromolecular complex. - Highlights: • Show applicability of projection assumption and weak-phase object approximation. • PA and WPOA are satisfied in cryo-EM tomograms at >30 AA resolution. • At ∼5 AA resolution PA and WPOA fail for typical macromolecules. • Thick phase grating approximation is an excellent substitute to multi-slice computation for life sciences

  1. The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

    DEFF Research Database (Denmark)

    Hecker, Markus; Hollert, Henner; Cooper, Ralph;

    2011-01-01

    on hormone production, confounding factors, such as cell viability and possible direct interference of test substances with antibody-based hormone detection assays, were assessed. Prior to and during the conduct of exposure experiments, each laboratory had to demonstrate that they were able to conduct...... the assay within the margin of predefined performance criteria.With a few exceptions, all laboratories met the key quality performance parameters, and only 2% and 7% of all experiments for T and E2, respectively, were excluded due to exceedance of these parameters. Of the 28 chemicals analyzed, 13 and 14...... associated with only one laboratory after a personnel change occurred. Significant interference of test chemicals with some of the antibody-based hormone detection systems occurred for four chemicals. Only one of these chemicals, however, significantly affected the ability of the detection system...

  2. Phase II Final Project Report SBIR Project: "A High Efficiency PV to Hydrogen Energy System"

    Energy Technology Data Exchange (ETDEWEB)

    Slade, A; Turner, J; Stone, K; McConnell, R

    2008-09-02

    The innovative research conducted for this project contributed greatly to the understanding of generating low-cost hydrogen from solar energy. The project’s research identified two highly leveraging and complementary pathways. The first pathway is to dramatically increase the efficiency of converting sunlight into electricity. Improving solar electric conversion efficiency directly increases hydrogen production. This project produced a world record efficiency for silicon solar cells and contributed to another world record efficiency for a solar concentrator module using multijunction solar cells. The project’s literature review identified a second pathway in which wasted heat from the solar concentration process augments the electrolysis process generating hydrogen. One way to do this is to use a “heat mirror” that reflects the heat-producing infrared and transmits the visible spectrum to the solar cells; this also increases solar cell conversion efficiency. An economic analysis of this concept confirms that, if long-term concentrator photovoltaic (CPV) and solid-oxide electrolyzer cost goals can be achieved, hydrogen will be produced from solar energy cheaper than the cost of gasoline. The potential public benefits from this project are significant. The project has identified a potential energy source for the nation’s future electricity and transportation needs that is entirely “home grown” and carbon free. As CPV enter the nation’s utility markets, the opportunity for this approach to be successful is greatly increased. Amonix strongly recommends further exploration of this project’s findings.

  3. Functional design criteria for Project W-252, Phase II Liquid Effluent Treatment and Disposal: Revision 1

    International Nuclear Information System (INIS)

    This document provides the functional design criteria required for the Phase 2 Liquid Effluent Treatment and Disposal Project, Project W-252. Project W-252 shall provide new facilities and existing facility modifications required to implement Best Available Technology/All Known, Available, and Reasonable Methods of Prevention, Control, and Treatment (BAT/AKART) for the 200 East Phase II Liquid Effluent Streams. The project will also provide a 200 East Area Phase II Effluent Collection System (PTECS) for connection to a disposal system for relevant effluent streams to which BAT/AKART has been applied. Liquid wastestreams generated in the 200 East Area are currently discharged to the soil column. Included in these wastestreams are cooling water, steam condensate, raw water, and sanitary wastewaters. It is the policy of the DOE that the use of soil columns to treat and retain radionuclides and nonradioactive contaminants be discontinued at the earliest practical time in favor of wastewater treatment and waste minimization. In 1989, the DOE entered into an interagency agreement with Ecology and EPA. This agreement is referred to as the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement). Project W-252 is one of the projects required to achieve the milestones set forth in the Tri-Party Agreement. One of the milestones requires BAT/AKART implementation for Phase II streams by October 1997. This Functional Design Criteria (FDC) document provides the technical baseline required to initiate Project W-252 to meet the Tri-Party Agreement milestone for the application of BAT/AKART to the Phase II effluents

  4. RF Phase Reference Distribution System for the TESLA Technology Based Projects

    CERN Document Server

    Czuba, K; Romaniuk, R S

    2013-01-01

    Since many decades physicists have been building particle accelerators and usually new projects became more advanced, more complicated and larger than predecessors. The importance and complexity of the phase reference distribution systems used in these accelerators have grown significantly during recent years. Amongst the most advanced of currently developed accelerators are projects based on the TESLA technology. These projects require synchronization of many RF devices with accuracy reaching femtosecond levels over kilometre distances. Design of a phase reference distribution system fulfilling such requirements is a challenging scientific task. There are many interdisciplinary problems which must be solved during the system design. Many, usually negligible issues, may became very important in such system. Furthermore, the design of a distribution system on a scale required for the TESLA technology based projects is a new challenge and there is almost no literature sufficiently covering this subject. This th...

  5. The use of microsomal in vitro assay to study phase I biotransformation of chlorobornanes (Toxaphene) in marine mammals and birds. Possible consequences of biotransformation for bioaccumulation and genotoxicity.

    Science.gov (United States)

    Boon, J P; Sleiderink, H M; Helle, M S; Dekker, M; van Schanke, A; Roex, E; Hillebrand, M T; Klamer, H J; Govers, B; Pastor, D; Morse, D; Wester, P G; de Boer, J

    1998-11-01

    The factors determining the bioaccumulation of lipophilic compounds in wildlife are often poorly understood, partly because it is difficult to do in vivo experiments with animals such as marine mammals and birds. To evaluate the role of phase I biotransformation in the bioaccumulation process of chlorobornanes (toxaphene), this was studied in in vitro assays with hepatic microsomes of animals that could be sampled shortly after death. The capacity of microsomes to metabolise a technical toxaphene mixture decreased in the order Phoca vitulina (harbour seal) > Lagenorhynchus albirostris (whitebeaked dolphin) approximately equal to Diomedea immutabilis (Laysan albatross) > Physeter macrocephalus (sperm whale). Harbour seal microsomes metabolised the chlorobornane (CHB) congeners CHB-32 and CHB-62; whitebeaked dolphin and Laysan albatross microsomes only metabolised CHB-32. Metabolism of CHB-26 and CHB-50 was never observed. The negative chemical ionisation (NCI-) mass spectra of some of the hydroxylated metabolites were obtained. The number of peaks in the toxaphene residues of wildlife extracts decreased in the order of increasing in-vitro biotransformation capacity. Thus, the results of the in vitro assays and residue analysis were in accordance, although assays with microsomes of more individuals of the same species are required for a more general conclusion at the species level. Finally, the effect of in vitro biotransformation was evaluated in terms of the genotoxic potential using the Mutatox assay. Only technical toxaphene and CHB-32 were genotoxic in the direct assay, whereas the addition of rat S9 fraction or microsomes of harbour seal and albatross decreased the genotoxic response. Thus, organisms with a low ability to metabolise chlorobornanes, such as whales, may be most affected by the carcinogenic properties of toxaphene. A hypothetical reaction which fits the experimental results is discussed. Based on these results it is concluded that in vitro assays

  6. Maqarin natural analogue project: Phase IV. Reconnaissance mission report (April 28 to May 7, 1999)

    International Nuclear Information System (INIS)

    Final planning of the Technical Proposal for Phase IV of the Maqarin Natural Analogue Project was preceded by a ten day Reconnaissance Mission to the Jordan sites. The main objective of this mission was to: i) allow new organisations within the project to become familiar with the geological context of the Maqarin and Central Jordan sites and also to appreciate the prevailing technical and logistical limitations, ii) carry out limited field investigations, and iii) based on the experience from these two points, provide the opportunity to finalise the Maqarin Phase IV Technical Proposal. This report details the results of the mission

  7. Maqarin natural analogue project: Phase IV. Reconnaissance mission report (April 28 to May 7, 1999)

    Energy Technology Data Exchange (ETDEWEB)

    Smellie, J.A.T. [ed.] [Conterra AB, Uppsala (Sweden)

    2000-08-01

    Final planning of the Technical Proposal for Phase IV of the Maqarin Natural Analogue Project was preceded by a ten day Reconnaissance Mission to the Jordan sites. The main objective of this mission was to: i) allow new organisations within the project to become familiar with the geological context of the Maqarin and Central Jordan sites and also to appreciate the prevailing technical and logistical limitations, ii) carry out limited field investigations, and iii) based on the experience from these two points, provide the opportunity to finalise the Maqarin Phase IV Technical Proposal. This report details the results of the mission.

  8. PHASE II CALDERON PROCESS TO PRODUCE DIRECT REDUCED IRON RESEARCH AND DEVELOPMENT PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Albert Calderon

    2002-10-29

    This project was initially targeted to the making of coke for blast furnaces by using proprietary technology of Calderon in a phased approach, and Phase I was successfully completed. The project was then re-directed to the making of iron units. U.S. Steel teamed up with Calderon for a joint effort which will last 30 months to produce directly reduced iron with the potential of converting it into molten iron or steel consistent with the Roadmap recommendations of 1998 prepared by the Steel Industry in cooperation with the Department of Energy.

  9. Reverse projection retrieval in edge illumination x-ray phase contrast computed tomography

    Science.gov (United States)

    Hagen, Charlotte K.; Endrizzi, Marco; Diemoz, Paul C.; Olivo, Alessandro

    2016-06-01

    Edge illumination (EI) x-ray phase contrast computed tomography (CT) can provide three-dimensional distributions of the real and imaginary parts of the complex refractive index (n=1-δ +\\text{i}β ) of the sample. Phase retrieval, i.e. the separation of attenuation and refraction data from projections that contain a combination of both, is a key step in the image reconstruction process. In EI-based x-ray phase contrast CT, this is conventionally performed on the basis of two projections acquired in opposite illumination configurations (i.e. with different positions of the pre-sample mask) at each CT angle. Displacing the pre-sample mask at each projection makes the scan susceptible to motor-induced misalignment and prevents a continuous sample rotation. We present an alternative method for the retrieval of attenuation and refraction data that does not require repositioning the pre-sample mask. The method is based on the reverse projection relation published by Zhu et al (2010 Proc. Natl Acad. Sci. USA 107 13576–81) for grating interferometry-based x-ray phase contrast CT. We use this relation to derive a simplified acquisition strategy that allows acquiring data with a continuous sample rotation, which can reduce scan time when combined with a fast read-out detector. Besides discussing the theory and the necessary alignment of the experimental setup, we present tomograms obtained with reverse projection retrieval and demonstrate their agreement with those obtained with the conventional EI retrieval.

  10. Initial phases of Financial Management System development project. Case: Diaconia UAS

    OpenAIRE

    Kainulainen, Tuukka

    2014-01-01

    The purpose of the study was to go through initial phases of financial management system development project. The case eterprise was chosen to be Diaconia University of Applied Sciences (further - Diak). The current Financial Management system of Diak is at its end due to the fact that the support for the system will end early spring 2015. The primary objective was to produce a solid foundation of information to the project team and to guide them with detailed analysis which...

  11. Managing Software Project Risks (Analysis Phase) with Proposed Fuzzy Regression Analysis Modelling Techniques with Fuzzy Concepts

    OpenAIRE

    Elzamly, Abdelrafe; Hussin, Burairah

    2014-01-01

    The aim of this paper is to propose new mining techniques by which we can study the impact of different risk management techniques and different software risk factors on software analysis development projects. The new mining technique uses the fuzzy multiple regression analysis techniques with fuzzy concepts to manage the software risks in a software project and mitigating risk with software process improvement. Top ten software risk factors in analysis phase and thirty risk management techni...

  12. A phased approach to cooperative environmental management R&D projects with Russian institutes

    Energy Technology Data Exchange (ETDEWEB)

    Matalucci, R.V. [Sandia National Labs., Albuquerque, NM (United States); Albert, T.E. [Science Applications International Corp., Clearwater, FL (United States)

    1994-10-01

    An important aspect of technology exchange between the US and the Former Society Union (FSU) countries is the identification and implementation of cooperative projects that are mutually beneficial. The US Department of Energy (DOE) and its national laboratories have established a four-phase approach to identify and further develop Russian technologies that could contribute to solving DOE environmental management problems. Following an initial screening and identification of potential technologies, the country-to-country interaction is formally initiated in the first phase through a small-scale pilot project study. This phase consists of an evaluation of the specific technology for DOE applications, and provides an opportunity for both US and Russian scientists and engineers to validate the use of the technology for a specific DOE requirement. The successful completion of this phase establishes the basis for continuing the technology development into the second phase, which includes laboratory testing in Russia. In the third phase, the technology is laboratory tested in the US, most likely at those DOE national laboratories having the capability and greatest interest in the particular technology area. The fourth and final phase consist of a commercialization process that establishes a partnership with a US business to finalize development of the technology and to prepare for implementation within the DOE complex. An example of this phased approach is a current high-level waste separation cooperative project between the Khlopin Radium Institute and the DOE through Sandia National Laboratories (SNL) and Science Applications International Corporation (SAIC). This effort has not only enhanced separations technology for the DOE, but has also provided an example of a working process for future cooperative projects.

  13. A phased approach to cooperative environmental management R ampersand D projects with Russian institutes

    International Nuclear Information System (INIS)

    An important aspect of technology exchange between the US and the Former Society Union (FSU) countries is the identification and implementation of cooperative projects that are mutually beneficial. The US Department of Energy (DOE) and its national laboratories have established a four-phase approach to identify and further develop Russian technologies that could contribute to solving DOE environmental management problems. Following an initial screening and identification of potential technologies, the country-to-country interaction is formally initiated in the first phase through a small-scale pilot project study. This phase consists of an evaluation of the specific technology for DOE applications, and provides an opportunity for both US and Russian scientists and engineers to validate the use of the technology for a specific DOE requirement. The successful completion of this phase establishes the basis for continuing the technology development into the second phase, which includes laboratory testing in Russia. In the third phase, the technology is laboratory tested in the US, most likely at those DOE national laboratories having the capability and greatest interest in the particular technology area. The fourth and final phase consist of a commercialization process that establishes a partnership with a US business to finalize development of the technology and to prepare for implementation within the DOE complex. An example of this phased approach is a current high-level waste separation cooperative project between the Khlopin Radium Institute and the DOE through Sandia National Laboratories (SNL) and Science Applications International Corporation (SAIC). This effort has not only enhanced separations technology for the DOE, but has also provided an example of a working process for future cooperative projects

  14. Application of isotopes and radiation to increasing agricultural production - Phase 2. Indonesia. Project findings and recommendations

    International Nuclear Information System (INIS)

    This Phase 2 Project was primarily aimed at consolidating the advances made during the previous phase, formulating practical agricultural technologies which can be adopted by farmers, disseminating and applying these technologies, and enhancing the capability of the Centre for Application of Isotopes and Radiation (CAIR) to conduct agricultural research using nuclear and related techniques. Outputs generated by this project were generally in accordance with those anticipated in the Project Document. Some outputs have been transferred to the target beneficiaries (farmers) through existing systems of extension, in co-operation with the main implementing agency (BATAN). Other outputs have potential for further assessment, and may lead to practical applications in future. The rest remain as important contributions to scientific knowledge. The project has been managed to assure sustainability after project termination. A strong indication of such sustainability is evident in the on-going research and development work at CAIR and the adoption of transferred technologies by the end-users. To keep up with rapid global advancements in bio-science and technology, a new project on application of nuclear and related techniques in agricultural bio-science and technology would be needed in relation to the second long-term phase of the national development programmes. (author)

  15. Aspects pertinent to the usefulness of a solid phase radio-immuno-sorbent assay for the detection of spermatozoa antibodies in sera of infertility patients

    International Nuclear Information System (INIS)

    The solid phase Radio-Immuno-Sorbent Assay (RISA) is a highly sensitive and valid test to detect 125-iodinetagged antibodies to spermatozoa that allows qualitative and quantitative evaluations of sperm-incapacitating immunglobulin Ig G in sera from patients believed to be infertile for immunological reasons. The study failed to reveal any correlations between the results of RISA and those of micro-sperm-agglutination or micro-sperm-immobilisation tests. There was a major body of evidence pointing to possible links between female isoimmunity and male autoimmunity. (TRV)

  16. Exercise Countermeasures Demonstration Project During the Lunar-Mars Life Support Test Project Phase 2A

    Science.gov (United States)

    Lee, Stuart M. C.; Guilliams, Mark E.; Moore, Alan D., Jr.; Williams, W. Jon; Greenisen, M. C.; Fortney, S. M.

    1998-01-01

    This demonstration project assessed the crew members' compliance to a portion of the exercise countermeasures planned for use onboard the International Space Station (ISS) and the outcomes of their performing these countermeasures. Although these countermeasures have been used separately in other projects and investigations, this was the first time they'd been used together for an extended period (60 days) in an investigation of this nature. Crew members exercised every day for six days, alternating every other day between aerobic and resistive exercise, and rested on the seventh day. On the aerobic exercise days, subjects exercised on an electronically braked cycle ergometer using a protocol that has been previously shown to maintain aerobic capacity in subjects exposed to a space flight analogue. On the resistive exercise days, crew members performed five major multijoint resistive exercises in a concentric mode, targeting those muscle groups and bones we believe are most severely affected by space flight. The subjects favorably tolerated both exercise protocols, with a 98% compliance to aerobic exercise prescription and a 91% adherence to the resistive exercise protocol. After 60 days, the crew members improved their peak aerobic capacity by an average 7%, and strength gains were noted in all subjects. These results suggest that these exercise protocols can be performed during ISS, lunar, and Mars missions, although we anticipate more frequent bouts with both protocols for long-duration spaceflight. Future projects should investigate the impact of increased exercise duration and frequency on subject compliance, and the efficacy of such exercise prescriptions.

  17. Fast reactor cycle technology development project (FaCT project). Phase 1 (Interim report)

    International Nuclear Information System (INIS)

    JAEA and JAPC launched Fast Reactor cycle Technology Development Project (FaCT) in 2006. 'The JAEA sodium-cooled loop-type fast reactor (JSFR) with MOX fuel, the advanced aqueous reprocessing, and the simplified pelletizing fuel fabrication systems' have been studied as a main concept in the FaCT project. JAEA targets 2015 in which the design concept that fulfills the development target and the design requirement is to be proposed. R and D system and R and D progress management have been improved and firmly established. Based on the indication of Japan Atomic Energy Commission and in cooperation with related organizations, R and Ds and design studies have been executed to evaluate innovative technologies. Direction in the adoption of the innovative technologies is to be determined in 2010. To attain this step, this report describes progress and results, and specifies issues and countermeasures upto 2008. This report also indicates future study procedure of the FaCT project. A CD-ROM is attached as an appendix. (J.P.N.)

  18. X-ray phase radiography and tomography with grating interferometry and the reverse projection technique

    International Nuclear Information System (INIS)

    X-ray grating interferometry provides substantially increased contrast over conventional absorption-based imaging methods, and therefore new and complementary information. Compared with other phase-contrast imaging techniques, x-ray grating interferometry can overcome some of the problems that have impaired the applications of x-ray phase-contrast radiography and phase tomography. Recently, special attention has been paid to the development of quantitative phase retrieval methods, which is mandatory to perform x-ray phase tomography, to achieve material identification, to differentiate distinct tissues, etc. Typically, the phase-stepping approach has been utilized for phase retrieval in grating interferometry. This method requires a grating scanning and acquisition of multiple radiographic projections, and therefore is disadvantageous in terms of imaging speed and radiation damage. Here we present an innovative, highly sensitive approach, dubbed ‘reverse projection’ (RP), for quantitative phase retrieval. Compared with the phase-stepping approach, the present RP method abandons grating scanning completely, and thus is advantageous due to its much higher efficiency and the reduced radiation dose, without the degradation of reconstruction quality. This review presents a detailed explanation of the principle of the RP method. Both radiography and phase tomography experiments are performed to validate the RP method. We believe that this new technique will find widespread applications in biomedical imaging and in vivo studies. (paper)

  19. Detection of endopeptidase activity and analysis of cleavage specificity using a radiometric solid-phase enzymatic assay

    International Nuclear Information System (INIS)

    A radiometric procedure to detect the presence of proteolytic enzymes and analyze their substrate specificity is described. The enzymatic activity is first measured by the release into solution of a radiolabeled reporter group from an immobilized peptidyl substrate. Two peptidyl substrates encompassing multiple cleavage sites, a derivative of Leu-enkephalin and a peptide related to the bait region of human α 2-macroglobulin, are prepared and linked via a spacer molecule to an insoluble support. The labeled peptides released are then separated by high-performance liquid chromatography. The position of the released peptides upon chromatography allows direct identification of the sites of cleavage. The assay, using a radioactive iodinated tyrosine residue as reporter group, is extremely sensitive (less than 0.02 pg/ml of trypsin), reproducible, and easy to perform while yielding unambiguous identification of the sites of cleavage. This assay can be used to detect the presence of enzymatic activities and/or of enzyme inhibitors. Furthermore, it can be easily adapted to detect from a variety of sources all four classes of enzymes known by using appropriate peptidyl substrate sequences, buffer, pH, and incubation conditions

  20. System definition phase and acquisition phase project plan for Small Astronomy Satellite SAS-D

    Science.gov (United States)

    1971-01-01

    The objective of the SAS-D project is to conduct spectral distribution studies of celestial ultraviolet sources using an Explorer-class spacecraft launched by a Delta vehicle into a geosynchronous orbit in the last half of 1975. The telescope system is intended for use by guest astronomers for a major portion of the total observing time. The concept of the overall system, designed to resemble functionally the operation of a ground-based observatory, should maximize the usefulness of the instrument to the astronomical community by limiting the amount of special instruction needed to use the spaceborne telescope. The SAS-D mission will obtain information on what stars, nebulae, and galaxies are and how they develop.

  1. A spatial algorithm to reduce phase wraps from two dimensional signals in fringe projection profilometry

    Science.gov (United States)

    Arevalillo-Herráez, Miguel; Gdeisat, Munther; Lilley, Francis; Burton, David R.

    2016-07-01

    In this paper, we present a novel algorithm to reduce the number of phase wraps in two dimensional signals in fringe projection profilometry. The technique operates in the spatial domain, and achieves a significant computational saving with regard to existing methods based on frequency shifting. The method works by estimating the modes of the first differences distribution in each axial direction. These are used to generate a tilted plane, which is subtracted from the entire phase map. Finally, the result is re-wrapped to obtain a phase map with fewer wraps. The method may be able to completely eliminate the phase wraps in many cases, or can achieve a significant phase wrap reduction that helps the subsequent unwrapping of the signal. The algorithm has been exhaustively tested across a large number of real and simulated signals, showing similar results compared to approaches operating in the frequency domain, but at significantly lower running times.

  2. Toxicity assessment of diesel- and metal-contaminated soils through elutriate and solid phase assays with the slime mold Dictyostelium discoideum.

    Science.gov (United States)

    Rodríguez-Ruiz, Amaia; Dondero, Francesco; Viarengo, Aldo; Marigómez, Ionan

    2016-06-01

    A suite of organisms from different taxonomical and ecological positions is needed to assess environmentally relevant soil toxicity. A new bioassay based on Dictyostelium is presented that is aimed at integrating slime molds into such a testing framework. Toxicity tests on elutriates and the solid phase developmental cycle assay were successfully applied to a soil spiked with a mixture of Zn, Cd, and diesel fuel freshly prepared (recently contaminated) and after 2 yr of aging. The elutriates of both soils provoked toxic effects, but toxicity was markedly lower in the aged soil. In the D. discoideum developmental cycle assay, both soils affected amoeba viability and aggregation, with fewer multicellular units, smaller fruiting bodies and, overall, inhibition of fruiting body formation. This assay is quick and requires small amounts of test soil, which might facilitate its incorporation into a multispecies multiple-endpoint toxicity bioassay battery suitable for environmental risk assessment in soils. Environ Toxicol Chem 2016;35:1413-1421. © 2015 SETAC. PMID:26450765

  3. Guangxi Shanglin Aluminum Plant cross-regional technical upgrade project(phase 1)put into operation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>The project(Phase 1)of cross-regional techni- cal upgrade of the aluminum plant of Guangxi Shanglin Nannan Industrial Co.was completed and put into operation on June 8,2007.The plant is a cross-regional technical upgrade pro- ject of Nanning Aluminum Plant,featuring the integration of coal,electricity and aluminum.

  4. Improving Highway Safety Manpower: Traffic Engineering Technician Project at Lansing Community College. Final Report, Phase I.

    Science.gov (United States)

    American Association of Community and Junior Colleges, Washington, DC.

    Phase I of this project was conducted to pilot test an associate degree program for the preparation of traffic safety technicians. Previously developed curriculum materials were revised by an advisory committee in accordance with the level of expertise and sophistication of the 27 students enrolled in the 2-year program and to meet the needs of…

  5. Small business innovation research. Abstracts of completed 1987 phase 1 projects

    Science.gov (United States)

    1989-01-01

    Non-proprietary summaries of Phase 1 Small Business Innovation Research (SBIR) projects supported by NASA in the 1987 program year are given. Work in the areas of aeronautical propulsion, aerodynamics, acoustics, aircraft systems, materials and structures, teleoperators and robotics, computer sciences, information systems, spacecraft systems, spacecraft power supplies, spacecraft propulsion, bioastronautics, satellite communication, and space processing are covered.

  6. Practice of the bar reinforcement jointing technique in the second phase of Qinshan Nuclear Power Project

    International Nuclear Information System (INIS)

    The jointing modalities, including lapping, flash welding, sleeve cold squeezed jointing, tapered thread of uniform strength and straight thread, are utilized in the second phase of Qinshan Nuclear Power Project. The application of the mechanical joint of the large-diameter bars is introduced emphatically. Meanwhile the technical and economic comparison are given for several kinds of bar joint modalities

  7. Managing Innovative Projects - Dynamics of Managerial Activities in the Front-End and Development Phases of Innovation Process

    OpenAIRE

    Rekonen, Satu

    2013-01-01

    Although there is a widespread agreement on the significant inherent disparities between different phases of innovation process, current management research largely ignores the differences of innovative project phases in the prescriptions of appropriate managerial activities. Further, not much emphasis has been put on the actual practices and actions of project managers, i.e., what is it that project managers actually do to manage innovative projects on a daily basis? This study addresses thi...

  8. OC5 Project Phase I: Validation of Hydrodynamic Loading on a Fixed Cylinder: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, A. N.; Wendt, F. F.; Jonkman, J. M.; Popko, W.; Vorpahl, F.; Stansberg, C. T.; Bachynski, E. E.; Bayati, I.; Beyer, F.; de Vaal, J. B.; Harries, R.; Yamaguchi, A.; Shin, H.; Kim, B.; van der Zee, T.; Bozonnet, P.; Aguilo, B.; Bergua, R.; Qvist, J.; Qijun, W.; Chen, X.; Guerinel, M.; Tu, Y.; Yutong, H.; Li, R.; Bouy, L.

    2015-04-23

    This paper describes work performed during the first half of Phase I of the Offshore Code Comparison Collaboration Continuation, with Correlation project (OC5). OC5 is a project run under the IEA Wind Research Task 30, and is focused on validating the tools used for modeling offshore wind systems. In this first phase, simulated responses from a variety of offshore wind modeling tools were modeling tools were validated against tank test data of a fixed, suspended cylinder (without a wind turbine) that was tested under regular and irregular wave conditions at MARINTEK. The results from this phase include an examination of different approaches one can use for defining and calibrating hydrodynamic coefficients for a model, and the importance of higher-order wave models in accurately modeling the hydrodynamic loads on offshore substructures.

  9. JSS project phase 4: Experimental and modelling studies of HLW glass dissolution in repository environments

    International Nuclear Information System (INIS)

    A goal of the JSS project was to develop a scientific basis for understanding the effects of waste package components, groundwater chemistry, and other repository conditions on glass dissolution behaviour, and to develop and refine a model for the processes governing glass dissolution. The fourth phase of the project, which was performed by the Hahn-Meitner-Institut, Berlin, FRG, dealt specifically with model development and application. Phase 4 also adressed whether basaltic glasses could serve as natural analogues for nuclear waste glasses, thus providing a means to test the capability of the model for long-term predictions. Additional experiments were performed in order to complete the data base necessary to model interactions between the glass and bentonite and between glass and steel corrosion products. More data on temperature, S/V, and pH dependence of the glass/water reaction were also collected. In this report, the data acquired during phase 4 are presented and discussed. (orig./DG)

  10. The Qinshan phase III project-a successful model of sino-canadian cooperation

    International Nuclear Information System (INIS)

    The Qinshan Phase III (CANDU) Project, the largest-scale cooperative project between China and Canada, was completed in 2003 well in advance of the schedule and 10% under budget. The Third Qinshan (Phase III) Nuclear Power Plant (TQNPP) was built in record times: Unit 1 achieved commercial operation on December 31, 2002 and Unit 2 on July 20, 2003, 43 days and 115 days ahead of schedule respectively. Improvements in design and construction methods allowed Unit 1 to be constructed in 51.5 months from First Concrete to Criticality - a record in China for nuclear power plants. The key factors are project management and project management tools, quality assurance, construction methods, electronic documentation with configuration control that provides up-to-date on-line information, CADDS design linked with material management and control. New design and construction techniques were introduced by combining conventional AECL practices with working experiences in China. The most advanced tools and techniques for achieving optimum construction quality, schedule and cost were used. Successful application of advanced project management methods and tools has benefited TQNPC in its subsequent plant operation, and the Chinese contractors in advancing their capabilities in future nuclear projects in China as well as enhancing their opportunities internationally. Excellent co-operation and teamwork within the integrated TQNPC/AECL Commissioning Team with well documented QA program, process and procedures also contributed to the remarkable success of the Project. AECL's initial assessment, based on lessons learned, showed that the project schedule could readily be reduced to 66 months and the capital costs reduced by 25% for a replication project. AECL is building on this experience and successful results of TQNPP in its Advanced CANDU ReactorTM (ACRTM)**design. (authors)

  11. Horonobe Underground Research Laboratory project synthesis of phase I investigations 2001 - 2005. Volume 'Geoscientific research'

    International Nuclear Information System (INIS)

    The Horonobe Underground Research Laboratory (URL) Project is being pursued by the Japan Atomic Energy Agency (JAEA) to enhance the reliability of relevant disposal technologies through investigations of the deep geological environment within the host sedimentary formations at Horonobe, northern Hokkaido. The project consists of two major research areas, Geoscientific Research' and 'R and D on Geological Disposal', and proceeds in three overlapping phases, 'Phase I: Surface-based investigation', 'Phase II: Construction' and 'Phase III: Operation', over a period of 20 years. The present report summarises the results of the Phase I geoscientific research carried out from March 2001 to March 2005. Integration of work from different disciplines into a 'geosynthesis' ensures that the Phase I goals have been successfully achieved and identifies key issues that need to be addressed in the Phase II/III investigations. More importantly, efforts are made to summarise as many lessons learnt from the Phase I investigations and other technical achievements as possible to form a 'knowledge base' that will reinforce the technical basis for both implementation and the formulation of safety regulations. Based on experiences of selecting the URL Area and the URL Site in Horonobe Town, important factors that should be taken into consideration in such site selection processes and their rationale are demonstrated. In the course of stepwise surface-based investigations, a number of achievements have been made, which can eventually provide examples of integrated methodologies for characterising the sedimentary formations. The relevant surface-based investigation techniques have thus been further developed. The Horonobe URL has been designed based on geoscientific information accumulated during the surface-based investigations and the plans for safe construction and operation of the URL have been defined in as feasible a manner as possible. In addition, a variety of environmental measures

  12. Horonobe Underground Research Laboratory project. Synthesis of phase I investigation 2001-2005. Volume 'geoscientific research'

    International Nuclear Information System (INIS)

    The Horonobe Underground Research Laboratory (URL) Project is being pursued by the Japan Atomic Energy Agency (JAEA) to enhance the reliability of relevant disposal technologies through investigations of the deep geological environment within the host sedimentary formations at Horonobe in Hokkaido, northern Japan. The project consists of two major research areas, 'Geoscientific Research' and 'R and D on Geological Disposal', and proceeds in three overlapping phases, 'Phase I: Surface-based investigation', 'Phase II: Construction' and 'Phase III: Operation', over a period of 20 years. The present report summarises the results of the Phase I geoscientific research carried out from March 2001 to March 2005. Integration of the results from different disciplines ensures that the Phase I goals have been successfully achieved and identifies key issues that need to be addressed in Phases II and III. More importantly, efforts are made to summarise as many lessons learnt from the Phase I investigations and other technical achievements as possible to form a 'knowledge base' that will reinforce the technical basis for both implementation and the formulation of safety regulations. Based on experiences of selecting the URL area and site in Horonobe Town, important factors that should be taken into consideration in such selection processes and their rationale are demonstrated. In the course of stepwise surface-based investigations, a number of achievements have been made, which can eventually provide examples of integrated methodologies for characterising the sedimentary formations. The relevant surface-based investigation techniques have thus been further developed. The Horonobe URL has been designed based on geoscientific information accumulated during the surface-based investigations and the plans for safe construction and operation of the URL have been defined in a feasible manner. In addition, a variety of environmental measures taken during Phase I have proved to be

  13. Fast reactor cycle technology development project (FaCT project). Phase I report

    International Nuclear Information System (INIS)

    JAEA and JAPC launched Fast Reactor Cycle Technology Development Project (FaCT) in 2006. 'The Japan sodium-cooled fast reactor (JSFR) with MOX fuel, the advanced aqueous reprocessing, and the simplified pelletizing fuel fabrication systems' have been studied as a main concept in the FaCT project. In 2010, a judgment on whether the innovative technologies should be adopted was made. In 2015, the design concept of the demonstration and commercial facilities for fast breeder reactor cycles that may fulfill the development targets as well as the R and D programs aimed at their commercialization are to be proposed. The adoption judgment of the innovative technologies was conducted focusing on the abovementioned main concept. To evaluate the sodium-cooled fast reactor (with MOX fuel) in terms of its design adequacy as a reactor system, 13 tasks of the innovative technologies were reduced to 10 tasks to fit more precisely with the targeting evaluation technology. As the result, 8 tasks were rated as adoptable. However, for a steam generator with double-walled straight tube, it was judged that heat exchanger tube with a protective tube should be selected as an alternative technology. Further, the assessments for the high-burnup reactor core and fuels are to be conducted in the two stages. Then finally cladding tubes materials will be selected on top of the judgment of necessity for alternative materials. For advanced aqueous reprocessing, 3 tasks of the innovative technologies were rated as adoptable. And, it was judged that the evaluation of other 3 tasks (i.e., effective uranium recovery system by crystallization technology, MA recovery technology by extraction chromatography method, waste reduction technology or waste polarizing technology) should be continued. For simplified pelletizing fuel fabrication, 3 tasks of the innovative technologies were rated as adoptable. And, it was judged that the evaluation of other 2 tasks (i.e., sintering and O/M ratio adjustment

  14. Technical Cross-Cutting Issues for the Next Generation Safeguards Initiative's Spent Fuel Nondestructive Assay Project

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, S. J.; Menlove, H. O.; Swinhoe, Martyn T.; Blanc, P.; Burr, T.; Evans, L. G.; Favalli, A.; Fensin, M. L.; Freeman, C. R.; Galloway, J.; Gerhart, J.; Rajasingam, A.; Rauch, E.; Sandoval, N. P.; Trellue, H.; Ulrich, T. J.; Conlin, J. L.; Croft, S.; Hendricks, John; Henzl, V.; Henzlova, D.; Eigenbrodt, J. M.; Koehler, W. E.; Lee, D. W.; Lee, T. H.; Lafleur, A. M.; Schear, M. A.; Humphrey, M. A.; Smith, Leon E.; Anderson, Kevin K.; Campbell, Luke W.; Casella, Andrew M.; Gesh, Christopher J.; Shaver, Mark W.; Misner, Alex C.; Amber, S. D.; Ludewigt, Bernhard A.; Quiter, B.; Solodov, Alexander; Charlton, W.; Stafford, A.; Romano, C.; Cheatham, J.; Ehinger, Michael; Thompson, S. J.; Chichester, David; Sterbentz, James; Hu, Jianwei; Hunt, A.; Mozin, Vladimir V.; Richard, J. G.

    2012-03-01

    Ever since there has been spent fuel (SF), researchers have made nondestructive assay (NDA) measurements of that fuel to learn about its content. In general these measurements have focused on the simplest signatures (passive photon and total neutron emission) and the analysis has often focused on diversion detection and on determining properties such as burnup (BU) and cooling time (CT). Because of shortcomings in current analysis methods, inspectorates and policy makers are interested in improving the state-of-the-art in SF NDA. For this reason the U.S. Department of Energy, through the Next Generation Safeguards Initiative (NGSI), targeted the determination of elemental Pu mass in SF as a technical goal. As part of this research effort, 14 nondestructive assay techniques were studied . This wide range of techniques was selected to allow flexibility for the various needs of the safeguards inspectorates and to prepare for the likely integration of one or more techniques having complementary features. In the course of researching this broad range of NDA techniques, several cross-cutting issues were. This paper will describe some common issues and insights. In particular we will describe the following: (1) the role of neutron absorbers with emphasis on how these absorbers vary in SF as a function of initial enrichment, BU and CT; (2) the need to partition the measured signal among different isotopic sources; and (3) the importance of the “first generation” concept which indicates the spatial location from which the signal originates as well as the isotopic origins.

  15. Laser Atmospheric Wind Sounder (LAWS) phase 1. Volume 3: Project cost estimates

    Science.gov (United States)

    1990-01-01

    The laser atmospheric wind sounder (LAWS) cost modeling activities were initiated in phase 1 to establish the ground rules and cost model that would apply to both phase 1 and phase 2 cost analyses. The primary emphasis in phase 1 was development of a cost model for a LAWS instrument for the Japanese Polar Orbiting Platform (JPOP). However, the Space Station application was also addressed in this model, and elements were included, where necessary, to account for Space Station unique items. The cost model presented in the following sections defines the framework for all LAWS cost modeling. The model is consistent with currently available detail, and can be extended to account for greater detail as the project definition progresses.

  16. The use of protein A in solid-phase binding assays: a comparison of four radioiodination techniques

    International Nuclear Information System (INIS)

    Preparations of protein A radioiodinated by 4 different methods have been compared in indirect radioimmunoassays. The oxidative methods (chloramine-T and iodogen) for direct iodination of tyrosyl and histidyl residues were applied with high efficiency and gave a suitable product, provided the substitution ratio was kept low (1 iodine atom/molecule of protein A). Higher levels of modification tended to perturb the Fsub(c)-binding characteristics of the protein, especially with the use of iodogen. Introduction of the isotope via substitution of lysyl residues (Bolton-Hunter and Wood reagents) was also examined. The Bolton-Hunter modification of protein A gave an unsuitably low labelling efficiency: in contrast, the Wood reagent gave efficiencies approaching 50%. Protein A could be extensively substituted with the latter reagent (>5 diiodinated benzimidate molecules per protein molecule). Thus, the use of the Wood-labeled protein A could raise the sensitivity of the binding assay at least an order of magnitude compared to using protein A iodinated by the oxidative methods. The effects on the biological activity of protein A exerted by the different labeling procedures are rationalized on the basis of the amino acid composition and tertiary structure of the protein. (Auth.)

  17. Technical realization of the VISA-2 Project, contract: 2.01/ I phase, Volume No. I

    International Nuclear Information System (INIS)

    Cooperation between the Institutes in Vinca and Saclay has started by carrying out the task 'Technical realization of the VISA-2 project' which should enable: obtaining new experimental spaces in the RA reactor with high fast neutron flux for sample irradiation; obtaining experience in reactor continual operation for few months at nominal power of 6.5 MW and increase of RA reactor utilization; solving the problem of activated channels and samples transport, problems of working in hot cells; obtaining irradiated samples for examining radiation effects first in Saclay and later in Vinca. The project is divided in three phases. Phase one covers the reconstruction of the RA reactor fuel channels according to the VISA-2 project demands. The second phase includes the activities related to measuring devices for measuring the temperatures at the incoming and outgoing heavy water in 5 VISA-2 channels, as well as temperature of the samples (55 thermocouples) and testing the channels and capsules after their insertion in the reactor. The third phase includes activities are related to problems of transport of radioactive channels and VISA-2 capsules, problems of cutting as well as packing and transporting of irradiated samples from Vinca to Saclay. This volume includes all the relevant documents for completing the task including contracts, needed preliminary calculations as well as safety analysis

  18. Synthesized research report in the second mid-term research phase. Mizunami Underground Research Laboratory project, Horonobe Underground Research Laboratory project and geo-stability project

    International Nuclear Information System (INIS)

    We have synthesised the research results from Mizunami/Horonobe URLs and geo-stability projects in the second mid-term research phase. It could be used as technical bases for NUMO/Regulator in each decision point from siting to beginning of disposal (Principal Investigation to Detailed Investigation Phase). High quality construction techniques and field investigation methods have been developed and implemented and these will be directly applicable to the National Disposal Program (along with general assessments of hazardous natural events and processes). It will be crucial to acquire technical knowledge on decisions of partial backfilling and final closure by actual field experiments in Mizunami/Horonobe URLs as main themes for the next phases. (author)

  19. The Pliocene Model Intercomparison Project (PlioMIP) Phase 2: Scientific Objectives and Experimental Design

    Science.gov (United States)

    Haywood, Alan M.; Dowsett, Harry J.; Dolan, Aisling M.; Rowley, David; Abe-Ouchi, Ayako; Otto-Bliesner, Bette; Chandler, Mark A.; Hunter, Stephen J.; Lunt, Daniel J.; Pound, Matthew; Salzmann, Ulrich

    2016-01-01

    The Pliocene Model Intercomparison Project (PlioMIP) is a co-ordinated international climate modelling initiative to study and understand climate and environments of the Late Pliocene, as well as their potential relevance in the context of future climate change. PlioMIP examines the consistency of model predictions in simulating Pliocene climate and their ability to reproduce climate signals preserved by geological climate archives. Here we provide a description of the aim and objectives of the next phase of the model intercomparison project (PlioMIP Phase 2), and we present the experimental design and boundary conditions that will be utilized for climate model experiments in Phase 2. Following on from PlioMIP Phase 1, Phase 2 will continue to be a mechanism for sampling structural uncertainty within climate models. However, Phase 1 demonstrated the requirement to better understand boundary condition uncertainties as well as uncertainty in the methodologies used for data-model comparison. Therefore, our strategy for Phase 2 is to utilize state-of-the-art boundary conditions that have emerged over the last 5 years. These include a new palaeogeographic reconstruction, detailing ocean bathymetry and land-ice surface topography. The ice surface topography is built upon the lessons learned from offline ice sheet modelling studies. Land surface cover has been enhanced by recent additions of Pliocene soils and lakes. Atmospheric reconstructions of palaeo-CO2 are emerging on orbital timescales, and these are also incorporated into PlioMIP Phase 2. New records of surface and sea surface temperature change are being produced that will be more temporally consistent with the boundary conditions and forcings used within models. Finally we have designed a suite of prioritized experiments that tackle issues surrounding the basic understanding of the Pliocene and its relevance in the context of future climate change in a discrete way.

  20. The Pliocene Model Intercomparison Project (PlioMIP) Phase 2: scientific objectives and experimental design

    Science.gov (United States)

    Haywood, Alan M.; Dowsett, Harry J.; Dolan, Aisling M.; Rowley, David; Abe-Ouchi, Ayako; Otto-Bliesner, Bette; Chandler, Mark A.; Hunter, Stephen J.; Lunt, Daniel J.; Pound, Matthew; Salzmann, Ulrich

    2016-03-01

    The Pliocene Model Intercomparison Project (PlioMIP) is a co-ordinated international climate modelling initiative to study and understand climate and environments of the Late Pliocene, as well as their potential relevance in the context of future climate change. PlioMIP examines the consistency of model predictions in simulating Pliocene climate and their ability to reproduce climate signals preserved by geological climate archives. Here we provide a description of the aim and objectives of the next phase of the model intercomparison project (PlioMIP Phase 2), and we present the experimental design and boundary conditions that will be utilized for climate model experiments in Phase 2. Following on from PlioMIP Phase 1, Phase 2 will continue to be a mechanism for sampling structural uncertainty within climate models. However, Phase 1 demonstrated the requirement to better understand boundary condition uncertainties as well as uncertainty in the methodologies used for data-model comparison. Therefore, our strategy for Phase 2 is to utilize state-of-the-art boundary conditions that have emerged over the last 5 years. These include a new palaeogeographic reconstruction, detailing ocean bathymetry and land-ice surface topography. The ice surface topography is built upon the lessons learned from offline ice sheet modelling studies. Land surface cover has been enhanced by recent additions of Pliocene soils and lakes. Atmospheric reconstructions of palaeo-CO2 are emerging on orbital timescales, and these are also incorporated into PlioMIP Phase 2. New records of surface and sea surface temperature change are being produced that will be more temporally consistent with the boundary conditions and forcings used within models. Finally we have designed a suite of prioritized experiments that tackle issues surrounding the basic understanding of the Pliocene and its relevance in the context of future climate change in a discrete way.

  1. Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay.

    Science.gov (United States)

    Wills, Lauren P; Beeson, Gyda C; Hoover, Douglas B; Schnellmann, Rick G; Beeson, Craig C

    2015-08-01

    Previous high-throughput screens to identify mitochondrial toxicants used immortalized cell lines and focused on changes in mitochondrial membrane potential, which may not be sufficient and do not identify different types of mitochondrial dysfunction. Primary cultures of renal proximal tubule cells (RPTC) were examined with the Seahorse Extracellular Flux Analyzer to screen 676 compounds (5 μM; 1 h) from the ToxCast Phase II library for mitochondrial toxicants. Of the 676 compounds, 19 were classified as cytotoxicants, 376 were electron transport chain (ETC) inhibitors, and 5 were uncouplers. The remaining 276 compounds were examined after a 5-h exposure to identify slower acting mitochondrial toxicants. This experiment identified 3 cytotoxicants, 110 ETC inhibitors, and 163 compounds with no effect. A subset of the ToxCast Phase II library was also examined in immortalized human renal cells (HK2) to determine differences in susceptibility to mitochondrial toxicity. Of the 131 RPTC ETC inhibitors tested, only 14 were ETC inhibitors in HK2 cells. Of the 5 RPTC uncouplers, 1 compound was an uncoupler in HK2 cells. These results demonstrate that 73% (491/676) of the compounds in the ToxCast Phase II library compounds exhibit RPTC mitochondrial toxicity, overwhelmingly ETC inhibition. In contrast, renal HK2 cells are markedly less sensitive and only identified 6% of the compounds as mitochondrial toxicants. We suggest caution is needed when studying mitochondrial toxicity in immortalized cell lines. This information will provide mechanisms and chemical-based criteria for assessing and predicting mitochondrial liabilities of new drugs, consumer products, and environmental agents. PMID:25926417

  2. The State of the Art of Occupational Competency Testing. National Occupational Competency Testing Project, Volume 2, Phase One.

    Science.gov (United States)

    Panitz, Adolf; Olivo, C. Thomas

    Experience has shown that the quality of instruction depends on the occupational competency of the teacher. The overall purpose of this project is to develop occupational competency examinations for nationwide use in evaluating trade and industrial education teachers. This first phase of the two-phase project involves: (1) surveying the state of…

  3. Project Management Phases of a SCADA System for Automation of Electrical Distribution Networks

    Directory of Open Access Journals (Sweden)

    Mohamed Najeh Lakhoua

    2012-03-01

    Full Text Available The aim of this paper is, firstly, to recall the basic concepts of SCADA (Supervisory Control And Data Acquisition systems, to present the project management phases of SCADA for real time implementation, and then to show the need of the automation for Electricity Distribution Companies (EDC on their distribution networks and the importance of using computer based system towards sustainable development of their services. A proposed computer based power distribution automation system is then discussed. Finally, some projects of SCADA system implementation in electrical companies over the world are briefly presented.

  4. SEROLOGY VERSUS SPUTUM MICROSCOPY AFTER THE INTENSIVE PHASE OF DOTS THERAPY: EVALUATION OF A MPT64 BASED ASSAY

    Directory of Open Access Journals (Sweden)

    Tamonud Modak

    2012-12-01

    Full Text Available Fast, sensitive, specific yet inexpensive methods for detection of tuberculosis remain elusive. In spite of its limitations sputum smear microscopy remains the most widely used method for it’s detection. Various commercial antigen based serological tests are being promoted as an alternative to sputum microscopy. These tests offer an economically viable pragmatic alternative to smear microscopy. Few studies exist evaluating the performance of serological tests after the intensive phase of DOTS. We believe to be an effective alternative to sputum microscopy; serology must perform reasonably well in all the stages of therapy. We evaluated the sensitivity and specificity of a single serological test after two months of intensive phase drug therapy in previously seropositive and smear positive patients attending the DOTS clinic of a tertiary care hospital. Our results showed a sensitivity of 0.5 (0.17-0.82 95% CI and a specificity of 0.25 (0.11-0.46 95% CI taking sputum smear microscopy as the gold standard. We concluded that the present formats of serological tests are not useful in differentiating an active infection from a recently cured infection. Further research must be done on detecting antibodies which reflect the true infection load.

  5. The optical modules of the phase-2 of the NEMO project

    Science.gov (United States)

    Aiello, S.; Leonora, E.; Ameli, F.; Anghinolfi, M.; Anzalone, A.; Barbarino, G.; Barbarito, E.; Barbato, F.; Bersani, A.; Beverini, N.; Biagi, S.; Bonori, M.; Bouhadef, B.; Bozza, C.; Cacopardo, G.; Capone, A.; Caruso, F.; Ceres, A.; Chiarusi, T.; Circella, M.; Cocimano, R.; Coniglione, R.; Cordelli, M.; Costa, M.; D'Amico, A.; De Asmundis, R.; De Bonis, G.; De Rosa, G.; De Vita, R.; Distefano, C.; Fermani, P.; Flaminio, V.; Fusco, L. A.; Garufi, F.; Giordano, V.; Giovanetti, G.; Grella, G.; Grimaldi, A.; Habel, R.; Imbesi, M.; Kulikovsky, V.; Lattuada, D.; Leotta, G.; Lonardo, A.; Longhitano, F.; Lo Presti, D.; Maccioni, E.; Margiotta, A.; Marinelli, A.; Martini, A.; Masullo, R.; Maugeri, F.; Migliozzi, P.; Migneco, E.; Minutoli, S.; Miraglia, A.; Mollo, C.; Mongelli, M.; Morganti, M.; Musico, P.; Musumeci, M.; Nicolau, C. A.; Orlando, A.; Papaleo, R.; Pappalardo, V.; Pellegrino, C.; Perrina, C.; Piattelli, P.; Pugliatti, C.; Pulvirenti, S.; Raffaelli, F.; Raia, G.; Randazzo, N.; Riccobene, G.; Rovelli, A.; Russo, A.; Russo, G. V.; Sapienza, P.; Sciliberto, D.; Sedita, M.; Sgura, I.; Shirokov, E.; Simeone, F.; Sipala, V.; Sollima, C.; Spina, M.; Spurio, M.; Stefani, F.; Taiuti, M.; Terreni, G.; Trasatti, L.; Trovato, A.; Vicini, P.; Viola, S.; Vivolo, D.

    2013-07-01

    A 13-inch Optical Module (OM) containing a large-area (10-inch) photomultiplier was designed as part of Phase-2 of the NEMO project. An intense R&D activity on the photomultipliers, the voltage supply boards, the optical coupling as well as the study of the influences of the Earth's magnetic field has driven the choice of each single component of the OM. Following a well-established production procedure, 32 OMs were assembled and their functionality tested. The design, the testing and the production phases are thoroughly described in this paper.

  6. The optical modules of the phase-2 of the NEMO project

    International Nuclear Information System (INIS)

    A 13-inch Optical Module (OM) containing a large-area (10-inch) photomultiplier was designed as part of Phase-2 of the NEMO project. An intense R and D activity on the photomultipliers, the voltage supply boards, the optical coupling as well as the study of the influences of the Earth's magnetic field has driven the choice of each single component of the OM. Following a well-established production procedure, 32 OMs were assembled and their functionality tested. The design, the testing and the production phases are thoroughly described in this paper

  7. Thickness Measurements from Single X-ray Phase-contrast Speckle Projection

    OpenAIRE

    Xi, Yan; Tang, Rongbiao; Ma, Jingchen; Zhao, Jun

    2015-01-01

    We propose a one-shot thickness measurement method for sponge-like structures using a propagation-based X-ray phase-contrast imaging (P-PCI) method. In P-PCI, the air-material interface refracts the incident X-ray. Refracted many times along their paths by such a structure, incident X-rays propagate randomly within a small divergent angle range, resulting in a speckle pattern in the captured image. We found structure thickness and contrast of a phase-contrast projection are directly related i...

  8. Planning and reporting of Russian transmutation research projects within ISTC. Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Conde, H. [Uppsala Univ. (Sweden). Dept. of Neutron Research; Gudowski, W. [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Reactor and Neutron Physics; Liljenzin, J.O. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Nuclear Chemistry; Mileikovsky, C. [Pully (Switzerland)

    1998-11-01

    The present report about phase 2 of the SKI project on Planning and Reporting of Russian Transmutation Research Projects within ISTC is an update of the information given in the SKI report no 97:15 (Feb 1997) about phase 1 of the same project. The background information is partly repeated in the present report to avoid that the reader has to go back to the report of Phase 1 for information about the basis for the project. USA, EU, Japan, Republic of Korea and Norway are at present supporting the International Scientific and Technical Center (ISTC) in Moscow. The Centre gives funds to research projects of civilian interest to former nuclear weapon laboratories to counteract the risk of nuclear weapon proliferation by the emigration of former USSR technical and scientific experts to `border countries` which are aiming towards the development of nuclear weapons. Before Sweden and Finland entered the EU, both countries gave national support to ISTC, in the case of Sweden 4 MUSD. Some of the projects which were funded by the Swedish national support to ISTC are still in progress. Nuclear technical concepts (i.e. Accelerator Transmutation of Nuclear Waste, ATW) have been proposed to incinerate and transmute long-lived radioactive nuclear waste to relax the time needed to store the waste in a geological repository. The named Russian experts are knowledgeable and well equipped of doing research in the different technical fields of relevance for the transmutation concepts. Thus, a number of ISTC projects have been initiated, and further ones have been proposed, to investigate different technical aspects of ATW with a result that a fair number of former weapon specialists have converted from military to peaceful civilian research. A similar centre STCU (The Scientific and Technical Centre of the Ukraine) has been set up in Kiev. Sweden has been active in promoting this Centre, which is supported by USA, Japan, Canada and recently also by EU. The present report describes the

  9. Planning and reporting of Russian transmutation research projects within ISTC. Phase 2

    International Nuclear Information System (INIS)

    The present report about phase 2 of the SKI project on Planning and Reporting of Russian Transmutation Research Projects within ISTC is an update of the information given in the SKI report no 97:15 (Feb 1997) about phase 1 of the same project. The background information is partly repeated in the present report to avoid that the reader has to go back to the report of Phase 1 for information about the basis for the project. USA, EU, Japan, Republic of Korea and Norway are at present supporting the International Scientific and Technical Center (ISTC) in Moscow. The Centre gives funds to research projects of civilian interest to former nuclear weapon laboratories to counteract the risk of nuclear weapon proliferation by the emigration of former USSR technical and scientific experts to 'border countries' which are aiming towards the development of nuclear weapons. Before Sweden and Finland entered the EU, both countries gave national support to ISTC, in the case of Sweden 4 MUSD. Some of the projects which were funded by the Swedish national support to ISTC are still in progress. Nuclear technical concepts (i.e. Accelerator Transmutation of Nuclear Waste, ATW) have been proposed to incinerate and transmute long-lived radioactive nuclear waste to relax the time needed to store the waste in a geological repository. The named Russian experts are knowledgeable and well equipped of doing research in the different technical fields of relevance for the transmutation concepts. Thus, a number of ISTC projects have been initiated, and further ones have been proposed, to investigate different technical aspects of ATW with a result that a fair number of former weapon specialists have converted from military to peaceful civilian research. A similar centre STCU (The Scientific and Technical Centre of the Ukraine) has been set up in Kiev. Sweden has been active in promoting this Centre, which is supported by USA, Japan, Canada and recently also by EU. The present report describes the

  10. Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay

    Directory of Open Access Journals (Sweden)

    Geiger Stefan Michael

    2001-01-01

    Full Text Available Angiostrongylus costaricensis may cause intestinal lesions of varied severity when it accidentally infects man in Central and South America. First-stage larvae have never been detected in stools. Therefore, a parasite-specific IgG ELISA was evaluated for the determination of the acute phase of infection. The specificity and the sensitivity of the immunoassay was shown to be 76.2% and 91.1%, respectively. Eight serum samples taken from patients with histopathological diagnosis, at different time points (3 to 15 months after surgical treatment, showed a sharp and early decline in antibody reactivity. The titration of anti-A. costaricensis antibodies has proved to be a useful method for the diagnosis of acute abdominal angiostrongyliasis.

  11. PHASE II CALDERON PROCESS TO PRODUCE DIRECT REDUCED IRON RESEARCH AND DEVELOPMENT PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Albert Calderon

    2006-04-19

    This project was initially targeted to the making of coke for blast furnaces by using proprietary technology of Calderon in a phased approach, and Phase I was successfully completed. The project was then re-directed to the making of iron units. In 2000, U.S. Steel teamed up with Calderon for a joint effort to produce directly reduced iron with the potential of converting it into molten iron or steel consistent with the Roadmap recommendations of 1998 prepared by the Steel Industry in cooperation with the Department of Energy by using iron ore concentrate and coal as raw materials, both materials being appreciably lower in cost than using iron pellets, briquettes, sinter and coke.

  12. Design of relief tank for Qinshan phase II nuclear power project

    International Nuclear Information System (INIS)

    The relief tank is the special equipment of the reactor coolant system. The purpose of this equipment is to collect, condensate and cool steam of the high temperature and the high pressure from the pressurizer safety valve or the relief valve and collect drain water from various systems. The author briefly introduces the design of the relief tank for the Qinshan Phase II nuclear power project. The design features of equipment are following: the material is selected reasonably, the steam is condensed completely, both condensing and cooling are done inside the equipment, the bursting disc device nozzle have the function of the man hole. The design of this equipment is rational, which is examined by the experts. The proprietor has a greed to use this equipment for the Qinshan Phase II nuclear power project

  13. The SNO+ Scintillator Purification Plant and Projected Sensitivity to Solar Neutrinos in the Pure Scintillator Phase

    Science.gov (United States)

    Pershing, Teal; SNO+ Collaboration

    2016-03-01

    The SNO+ detector is a neutrino and neutrinoless double-beta decay experiment utilizing the renovated SNO detector. In the second phase of operation, the SNO+ detector will contain 780 tons of organic liquid scintillator composed of 2 g/L 2,5-diphenyloxazole (PPO) in linear alkylbenzene (LAB). In this phase, SNO+ will strive to detect solar neutrinos in the sub-MeV range, including CNO production neutrinos and pp production neutrinos. To achieve the necessary detector sensitivity, a four-part scintillator purification plant has been constructed in SNOLAB for the removal of ionic and radioactive impurities. We present an overview of the SNO+ scintillator purification plant stages, including distillation, water extraction, gas stripping, and metal scavenger columns. We also give the projected SNO+ sensitivities to various solar-produced neutrinos based on the scintillator plant's projected purification efficiency.

  14. PHASE II CALDERON PROCESS TO PRODUCE DIRECT REDUCED IRON RESEARCH AND DEVELOPMENT PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Albert Calderon

    2004-04-27

    This project was initially targeted to the making of coke for blast furnaces by using proprietary technology of Calderon in a phased approach, and Phase I was successfully completed. The project was then re-directed to the making of iron units. In 2000, U.S. Steel teamed up with Calderon for a joint effort which will last 42 months to produce directly reduced iron with the potential of converting it into molten iron or steel consistent with the Roadmap recommendations of 1998 prepared by the Steel Industry in cooperation with the Department of Energy by using iron ore concentrate and coal as raw materials, both materials being appreciably lower in cost than using iron pellets and coke.

  15. A rapid and sensitive assay of perfluorocarboxylic acids in aqueous matrices by headspace solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry.

    Science.gov (United States)

    Monteleone, Marcello; Naccarato, Attilio; Sindona, Giovanni; Tagarelli, Antonio

    2012-08-17

    The work aims at developing a rapid and sensitive method for the quantification of perfluorocarboxylic acids in aqueous matrices. The proposed analytical approach is based on the use of solid phase microextraction in headspace mode after a fast derivatization of the carboxylate function by propylchloroformate/propanol mixture. Several fibers were evaluated and the optimization of the parameters affecting the SPME process was carried out using a central composite design. The optimum working conditions in terms of response values were achieved by performing analysis with CAR/PDMS fiber at room temperature, without addition of NaCl, with a sample volume of 6 ml and an extraction time of 10 min. Assay of PFCAs was performed by using a gas chromatography-triple quadrupole mass spectrometry (GC-QqQ MS) system in negative chemical ionization mode with ammonia as reagent gas. An overall evaluation of all analytical parameters shows that the proposed method provides satisfactory results. In particular, the observed accuracies, ranging from 84.4% to 116.8%, and the RSD values in the range 0.4% and 14.5% confirm the effectiveness of the developed protocol in the assay of PFCAs content in aqueous matrices. Moreover, LOD and LOQ values ranging from 0.08 to 6.6 ng l(-1) and from 0.17 to 14.3 ng l(-1), respectively, can be considered very satisfactory. None of the compounds were detected in six samples of river collected in Calabria. PMID:22762954

  16. Status of JSFR development in phase I FaCT project

    International Nuclear Information System (INIS)

    The Fast Reactor Cycle Technology Development (FaCT) project is pursuing commercialization of fast reactor cycle system around 2050 under cooperation of MEXT (Ministry of Education, Culture, Sports, Science and Technology), METI (Ministry of Economy, Trade and Industry), utilities, venders and JAEA (Japan Atomic Energy Agency). As results of the FaCT Phase I, the key technologies for Japan Sodium-cooled Fast Reactor (JSFR) has been evaluated. (author)

  17. Advanced conceptual design report. Phase II. Liquid effluent treatment and disposal Project W-252

    International Nuclear Information System (INIS)

    This Advanced Conceptual Design Report (ACDR) provides a documented review and analysis of the Conceptual Design Report (CDR), WHC-SD-W252-CDR-001, June 30, 1993. The ACDR provides further design evaluation of the major design approaches and uncertainties identified in the original CDR. The ACDR will provide a firmer basis for the both the design approach and the associated planning for the performance of the Definitive Design phase of the project

  18. Advanced conceptual design report. Phase II. Liquid effluent treatment and disposal Project W-252

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-31

    This Advanced Conceptual Design Report (ACDR) provides a documented review and analysis of the Conceptual Design Report (CDR), WHC-SD-W252-CDR-001, June 30, 1993. The ACDR provides further design evaluation of the major design approaches and uncertainties identified in the original CDR. The ACDR will provide a firmer basis for the both the design approach and the associated planning for the performance of the Definitive Design phase of the project.

  19. Analysis and control of welding deformation in Qinshan nuclear power phase II extension project

    International Nuclear Information System (INIS)

    The paper analyzes the severe deformation in the welding of core barrel in Qinshan Nuclear Power Phase II Extension Project Reactor No. 3 unit, which nearly induces the loss of the function of the core barrel. Measures such as improving the welding fixture,process and parameter, and loading the counterweight is taken for the No. 4 unit to minimize the deformation, and the result shows that the weld of the No. 4 core barrel satisfies the design requirements. (authors)

  20. Highway Electrification And Automation Technologies - Regional Impacts Analysis Project: Phase I: Baseline Scenario Data Analysis

    OpenAIRE

    Scag; Path

    1993-01-01

    The Highway Electrification and Automation Technologies Regional Impacts Analysis Project addresses the transportation-related problems of freeway congestion, air pollution, and dependence on fossil fuels in southern California. This report presents a documentation of the basis for the impacts analysis. It contains sections on data collected, baseline forecast for 2025, and electrification and automation specification scenarios. This report constitutes the final report for Phase I of the proj...

  1. Characterization of holographically generated beams via phase retrieval based on Wigner distribution projections

    OpenAIRE

    Rodrigo, José A.; Alieva, Tatiana; Cámara, Alejando; Martínez Matos, Ó.; Cheben, Pavell; Calvo, María L.

    2011-01-01

    In this work, we propose a robust and versatile approach for the characterization of the complex field amplitude of holographically generated coherent-scalar paraxial beams. For this purpose we apply an iterative algorithm that allows recovering the phase of the generated beam from the measurement of its Wigner distribution projections. Its performance is analyzed for beams of different symmetry: Laguerre-Gaussian, Hermite- Gaussian and spiral ones, which are obtained experimentally by a comp...

  2. FALSIRE Phase II. CSNI project for Fracture Analyses of Large-Scale International Reference Experiments (Phase II). Comparison report

    International Nuclear Information System (INIS)

    A summary of Phase II of the Project for Fracture Analysis of Large-Scale International Reference Experiments (FALSIRE) is presented. A FALSIRE II Workshop focused on analyses of reference fracture experiments. More than 30 participants representing 22 organizations from 12 countries took part in the workshop. Final results for 45 analyses of the reference experiments were received from the participating analysts. For each experiment, analysis results provided estimates of variables that include temperature, crack-mouth-opening displacement, stress, strain, and applied K and J values. The data were sent electronically to the Organizing Committee, who assembled the results into a comparative data base using a special-purpose computer program. A comparative assessment and discussion of the analysis results are presented in the report. Generally, structural responses of the test specimens were predicted with tolerable scatter bands. (orig./DG)

  3. Columbia River pathway report: phase I of the Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    1991-07-01

    This report summarizes the river-pathway portion of the first phase of the Hanford Environmental Dose Reconstruction (HEDR) Project. The HEDR Project is estimating radiation doses that could have been received by the public from the Department of Energy's Hanford Site, in southeastern Washington State. Phase 1 of the river-pathway dose reconstruction effort sought to determine whether dose estimates could be calculated for populations in the area from above the Hanford Site at Priest Rapids Dam to below the site at McNary Dam from January 1964 to December 1966. Of the potential sources of radionuclides from the river, fish consumption was the most important. Doses from drinking water were lower at Pasco than at Richland and lower at Kennewick than at Pasco. The median values of preliminary dose estimates calculated by HEDR are similar to independent, previously published estimates of average doses to Richland residents. Later phases of the HEDR Project will address dose estimates for periods other than 1964--1966 and for populations downstream of McNary Dam. 17 refs., 19 figs., 1 tab.

  4. Supply curve impacts of Quick Start projects in Phase 1 of the Resource Supply Expansion Program

    Energy Technology Data Exchange (ETDEWEB)

    Wright, G.A.; Warwick, W.M.; Durfee, D.L.

    1993-12-01

    The Pacific Northwest Laboratory (PNL) prepared this report under contract to the Bonneville Power Administration (Bonneville), as part of the Resource Supply Expansion Project (RSEP). RSEP is a regional program instituted by Bonneville to expand conservation and renewable generation options available to resource planners and utilities. Resource alternatives are increased by RSEP through demonstration projects designed in a collaborative process that targets specific barriers to resource development including institutional, market, and reliability barriers. RSEP was launched with several projects that were designed and implemented quickly in 1992 to lay a foundation for future collaboration. The purpose of this report is to introduce the goal and structure of RSEP and to describe the so-called ``Quick Start`` RSEP projects in Phase One of RSEP. This description includes a preliminary estimate of the energy savings and/or other expected impacts of RSEP projects funded in FY 1992 and 1993. Similar estimates are also included for Bonneville projects to confirm wind and geothermal generation potential. Bonneville`s Geothermal Confirmation Agenda preceded implementation of RSEP, although it has a similar objective and collaborative approach.

  5. 75 FR 5279 - Sucker Creek Channel and Floodplain Restoration Project (Phase II), Rogue River-Siskiyou National...

    Science.gov (United States)

    2010-02-02

    ... project reach (Sucker Creek) has changed over time due to the effects of hydraulic and placer mining...; ] DEPARTMENT OF AGRICULTURE Forest Service Sucker Creek Channel and Floodplain Restoration Project (Phase II..., reduce stream temperature, and reduce excessive fine sediment inputs from the project reach....

  6. Water Use Optimization Toolset Project: Development and Demonstration Phase Draft Report

    Energy Technology Data Exchange (ETDEWEB)

    Gasper, John R. [Argonne National Laboratory; Veselka, Thomas D. [Argonne National Laboratory; Mahalik, Matthew R. [Argonne National Laboratory; Hayse, John W. [Argonne National Laboratory; Saha, Samrat [Argonne National Laboratory; Wigmosta, Mark S. [PNNL; Voisin, Nathalie [PNNL; Rakowski, Cynthia [PNNL; Coleman, Andre [PNNL; Lowry, Thomas S. [SNL

    2014-05-19

    This report summarizes the results of the development and demonstration phase of the Water Use Optimization Toolset (WUOT) project. It identifies the objective and goals that guided the project, as well as demonstrating potential benefits that could be obtained by applying the WUOT in different geo-hydrologic systems across the United States. A major challenge facing conventional hydropower plants is to operate more efficiently while dealing with an increasingly uncertain water-constrained environment and complex electricity markets. The goal of this 3-year WUOT project, which is funded by the U.S. Department of Energy (DOE), is to improve water management, resulting in more energy, revenues, and grid services from available water, and to enhance environmental benefits from improved hydropower operations and planning while maintaining institutional water delivery requirements. The long-term goal is for the WUOT to be used by environmental analysts and deployed by hydropower schedulers and operators to assist in market, dispatch, and operational decisions.

  7. Phase Retrieval with One or Two Diffraction Patterns by Alternating Projections of the Null Vector

    CERN Document Server

    Chen, Pengwen; Liu, Gi-Ren

    2015-01-01

    Two versions of alternating projection (AP), the parallel alternating projection (PAP) and the serial alternating projection (SAP), are proposed to solve phase retrieval with at most two coded diffraction patterns. The proofs of geometric convergence are given with sharp bounds on the rates of convergence in terms of a spectral gap condition. To compensate for the local nature of convergence, the null vector method is proposed for initialization and proved to produce asymptotically accurate initialization for the Gaussian case. Extensive numerical experiments are performed to show that the null vector method produces more accurate initialization than the spectral vector method and that PAP/SAP converge faster to more accurate solutions than other iterative schemes for non-convex optimization such as the Wirtinger flow. Moreover, SAP converges still faster than PAP. In practice AP and the null vector method together produce globally convergent iterates to the true object.

  8. State partnership in environmental health and safety phase of Plowshare projects

    International Nuclear Information System (INIS)

    When experiments on projects involving Plowshare devices are conceived, the state chosen for the project should be invited to participate in planning the health and safety aspects and be prepared to actively participate in the D-Day phase as well as the post-detonation activity. In California nuclear science technology and competence have preceded the social acceptance and use of nuclear devices for large scale Plowshare projects. However, the environmental surveillance program of the Bureau of Radiological Health in the State Department of Public Health has established an operative program which will be ready and able to function as an active participant or in a support role in environmental health phases of nuclear projects scheduled in the State. A description of our present program will be included in this paper. This will enable the attendees and readers to realize capabilities which will be activated for participation and/or support roles during Plowshare activities in the State or in a neighboring state if the need arises. (author)

  9. Sakhalin 2, phase 2 project : meeting the Arctic challenge in a sub-Arctic environment

    International Nuclear Information System (INIS)

    Sakhalin Energy's objective is to commercially develop, operate and market the hydrocarbon resources and associated infrastructure governed by the Sakhalin 2 licenses for the sustainable benefit of shareholders, the Russian Federation, the Sakhalin Oblast and the wider community. This presentation discussed Sakhalin Energy's holdings including its investment company and hydrocarbon projects in eastern Russia. The Sakhalin area is a remote island that lacks infrastructure, has a low population density, with a rich onshore and offshore wildlife. It is a seismically active area, with seasonal operating windows, drifting pack ice from December to June, waves up to 18 metre maximum height, and frequent fog in spring and summer. The temperature also varies from 28 degrees Celsius to -40 degrees Celsius. The presentation also addressed the rerouting of offshore pipelines to ensure the least possible disturbance to western gray whale migration. Several photographs and illustrations of the phase 1 project were presented. Open water conditions were also illustrated. The phase 2 project was then outlined. This included illustrations of the platform, plant and export terminal, and onshore processing facility. Other photographs that were shown in the presentation included the offshore pipeline installation; a view of the shore approach to the pipeline installation; oil spill response; and escape, evacuation, and response. The design challenges and design philosophy of the project were also identified. The presentation concluded with a discussion of ice loading and platform response. figs

  10. Final Report for Phase I Northern California CO2 Reduction Project

    Energy Technology Data Exchange (ETDEWEB)

    Wagoner, J

    2010-10-26

    On June 8, 2009, the U. S. Department of Energy's National Energy Technology Laboratory released a Funding Opportunity Announcement (DE-FOA 0000015) with the title, Recovery Act: Carbon Capture and Sequestration from Industrial Sources and Innovative Concepts for Beneficial CO{sub 2} Use. C6 Resources (C6), an affiliate of Shell Oil Company, responded with a proposal for Technology Area 1: Large-scale industrial carbon capture and sequestration (CCS) projects from industrial sources. As DOE Federally Funded Research and Development Center (FFRDC) Contractors, Lawrence Livermore National Laboratory (LBNL) and Lawrence Berkeley National Laboratory (LLNL) proposed to collaborate with C6 and perform technical tasks, which C6 included in the C6 proposal, titled the Northern California CO{sub 2} Reduction Project. The proposal was accepted for Phase I funding and C6 received DOE Award DEFE0002042. LLNL and LBNL each received Phase I funding of $200,000, directly from DOE. The essential task of Phase I was to prepare a proposal for Phase II, which would be a five-year, detailed technical proposal, budget, and schedule for a complete carbon capture, transportation, and geologic storage project, with the objective of starting the injection of 1 million tons per year of industrial CO2 by the end of FY2015. LLNL and LBNL developed technical proposals (and DOE Field Work Proposals [FWPs]) for many aspects of the geologic testing and CO{sub 2} monitoring that were included in the C6 Phase II proposal, which C6 submitted by the deadline of April 16, 2010. This document is the Final Report for LLNL's Phase I efforts and is presented in two parts. Part 1 is the complete text of the technical proposal provided to C6 by LLNL and LBNL for inclusion in the C6 Phase II proposal. Because of space limitations, however, C6 may not have included all of this information in their proposal. In addition to developing the proposal presented below, LLNL's Bill Foxall and Laura

  11. Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay

    Directory of Open Access Journals (Sweden)

    Asefnejad A

    2011-10-01

    Full Text Available Azadeh Asefnejad1, Mohammad Taghi Khorasani2, Aliasghar Behnamghader3, Babak Farsadzadeh1, Shahin Bonakdar4 1Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Iran Polymers and Petrochemical Institute, Tehran, Iran; 3Materials and Energy Research Center, Tehran, Iran; 4National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran Background: Biodegradable polyurethanes have found widespread use in soft tissue engineering due to their suitable mechanical properties and biocompatibility. Methods: In this study, polyurethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and a copolymer of 1,4-butanediol as a chain extender. Polyurethane scaffolds were fabricated by a combination of liquid–liquid phase separation and salt leaching techniques. The effect of the NCO:OH ratio on porosity content and pore morphology was investigated. Results: Scanning electron micrographs demonstrated that the scaffolds had a regular distribution of interconnected pores, with pore diameters of 50–300 µm, and porosities of 64%–83%. It was observed that, by increasing the NCO:OH ratio, the average pore size, compressive strength, and compressive modulus increased. L929 fibroblast and chondrocytes were cultured on the scaffolds, and all samples exhibited suitable cell attachment and growth, with a high level of biocompatibility. Conclusion: These biodegradable polyurethane scaffolds demonstrate potential for soft tissue engineering applications. Keywords: polyurethane, tissue engineering, biodegradable, fibroblast cells

  12. Draft Air Pathway Report: Phase 1 of the Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    1990-07-20

    This report summarizes the air pathway portion of the first phase of the Hanford Environmental Dose Reconstruction (HEDR) Project, conducted by Battelle staff at the Pacific Northwest Laboratory under the direction of an independent Technical Steering Panel. The HEDR Project is estimating historical radiation doses that could have been received by populations near the Department of Energy's Hanford Site, in southeastern Washington State. Phase 1 of the air-pathway dose reconstruction sought to determine whether dose estimates could be calculated for populations in the 10 counties nearest the Hanford Site from atmospheric releases of iodine-131 from the site from 1944--1947. Phase 1 demonstrated the following: HEDR-calculated source-term estimates of iodine-131 releases to the atmosphere were within 20% of previously published estimates; calculated vegetation concentrations of iodine-131 agree well with previously published measurements; the highest of the Phase 1 preliminary dose estimates to the thyroid are consistent with independent, previously published estimates of doses to maximally exposed individuals; and relatively crude, previously published measurements of thyroid burdens for Hanford workers are in the range of average burdens that the HEDR model estimated for similar reference individuals'' for the period 1944--1947. 4 refs., 10 figs., 9 tabs.

  13. Thickness Measurements from Single X-ray Phase-contrast Speckle Projection

    CERN Document Server

    Xi, Yan; Ma, Jingchen; Zhao, Jun

    2015-01-01

    We propose a one-shot thickness measurement method for sponge-like structures using a propagation-based X-ray phase-contrast imaging (P-PCI) method. In P-PCI, the air-material interface refracts the incident X-ray. Refracted many times along their paths by such a structure, incident X-rays propagate randomly within a small divergent angle range, resulting in a speckle pattern in the captured image. We found structure thickness and contrast of a phase-contrast projection are directly related in images. This relationship can be described by a natural logarithm equation. Thus, from the one phase-contrast view, depth information can be retrieved from its contrast. Our preliminary biological experiments indicate promise in its application to measurements requiring in vivo and ongoing assessment of lung tumor progression.

  14. Code of Conduct for wind-power projects - Phases 1 and 2; Code of Conduct fuer windkraftprojekte. Phase 1 und 2 - Systemanalyse, Lessons Learned und Bewertung bestehender Instrumente

    Energy Technology Data Exchange (ETDEWEB)

    Strub, P. [Pierre Strub, freischaffender Berater, Binningen (Switzerland); Ziegler, Ch. [Inter Act, Basel (Switzerland)

    2008-08-15

    This paper discusses the results of the first two phases of a project concerning wind-power projects. The paper deals with the results of a system analysis, takes a look at lessons learned and presents an appraisal of existing instruments. A system-analysis of wind-power projects is presented with emphasis on social factors and the role of stakeholders. The success factors concerning social acceptance of wind-power projects and their special characteristics are discussed. Lessons learned are examined. Instruments for the sustainable implementation of projects are looked at, in particular with a focus on social acceptance

  15. Phase 1 Characterization sampling and analysis plan West Valley demonstration project.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R. L. (Environmental Science Division)

    2011-06-30

    The Phase 1 Characterization Sampling and Analysis Plan (CSAP) provides details about environmental data collection that will be taking place to support Phase 1 decommissioning activities described in the Phase 1 Decommissioning Plan for the West Valley Demonstration Project, Revision 2 (Phase I DP; DOE 2009). The four primary purposes of CSAP data collection are: (1) pre-design data collection, (2) remedial support, (3) post-remediation status documentation, and (4) Phase 2 decision-making support. Data collection to support these four main objectives is organized into two distinct data collection efforts. The first is data collection that will take place prior to the initiation of significant Phase 1 decommissioning activities (e.g., the Waste Management Area [WMA] 1 and WMA 2 excavations). The second is data collection that will occur during and immediately after environmental remediation in support of remediation activities. Both data collection efforts have a set of well-defined objectives that encompass the data needs of the four main CSAP data collection purposes detailed in the CSAP. The main body of the CSAP describes the overall data collection strategies that will be used to satisfy data collection objectives. The details of pre-remediation data collection are organized by WMA. The CSAP contains an appendix for each WMA that describes the details of WMA-specific pre-remediation data collection activities. The CSAP is intended to expand upon the data collection requirements identified in the Phase 1 Decommissioning Plan. The CSAP is intended to tightly integrate with the Phase 1 Final Status Survey Plan (FSSP). Data collection described by the CSAP is consistent with the FSSP where appropriate and to the extent possible.

  16. Fluid-phase immunoradiometric assay for the detection of qualitative abnormalities of factor VIII/von Willebrand factor in variants of von Willebrand's disease

    International Nuclear Information System (INIS)

    Antigenic reactivity of F.VIII/WF in variants of von Willebrand's disease (vWd) was studied with both fluid-phase and solid-phase immunoradiometric assays. Two different (rabbit and goat) 125I-labeled specific antibodies against purified F.VIII/WF were used in both their divalent (lgG) and their monovalent (Fab fragment) forms. Dose-response curves obtained by reacting a constant amount of antibody with serial dilutions of plasmas from normal or homozygous vWd demonstrated the specificity of the test. The accuracy was significantly higher with 125I-Fab fragments of goat anti-F.VIII/WF antiserum than intact goat lgG or rabbit lgG or Fab fragments. The significant decrease of the slope of the dose-response curves obtained with plasma from variants of vWd has been interpreted as due to the presence of abnormal F.VIII/WF molecules with decreased antigenic reactivity. A similar anomaly was found in cryosupernatant prepared from normal plasma, paralleling similarities demonstrated between variants of vWd and cryosupernatant. Results of experiments performed by reacting constant plasma dilutions from control or variants of vWd and varying concentrations of anti-F.VIII/WF Fab fragments (rabbit or goat) confirmed the decreased antigenic reactivity of variant F.VIII/WF

  17. Results of the Boeing/DOE DECC Phase 1 stirling engine project

    Energy Technology Data Exchange (ETDEWEB)

    STONE,KENNETH W.; CLARK,TERRY; NELVING,HANS; DIVER JR.,RICHARD B.

    2000-03-02

    Phase I of Boeing Company/DOE Dish Engine Critical Component (DECC) Project started in April of 1998 and was completed in 1999. The Phase I objectives, schedule, and test results are presented in this paper. These data shows the power, energy, and mirror performance are comparable to that when the hardware was first manufactured 15 years ago. During the Phase I and initial Phase II test period the on-sun system accumulated over 3,800 hours of solar-powered operating time, accumulated over 4,500 hours of concentrator solar tracking time, and generated over 50,000 kWh of grid-compatible electrical energy. The data also shows that the system was available 95 {percent} of the time when the sun's insolation level was above approximately 300 w/m{sup 2}, and achieved a daily energy efficiency between 20{percent} and 26{percent}. A second concentrator was refurbished during Phase I and accumulated over 2,200 hours of solar track time. A second Stirling engine operated 24 hours a day in a test cell in Sweden and accumulated over 6,000 test hours. Discussion of daily operation shows no major problems encountered during the testing that would prevent commercialization of the technology. Further analysis of the test data shows that system servicing with hydrogen, coolant and lubricating oil should not be a major O and M cost.

  18. A strategic plan for the second phase (2013-2015) of the Korea biobank project.

    Science.gov (United States)

    Park, Ok; Cho, Sang Yun; Shin, So Youn; Park, Jae-Sun; Kim, Jun Woo; Han, Bok-Ghee

    2013-04-01

    The Korea Biobank Project (KBP) was led by the Ministry of Health and Welfare to establish a network between the National Biobank of Korea and biobanks run by university-affiliated general hospitals (regional biobanks). The Ministry of Health and Welfare started the project to enhance medical and health technology by collecting, managing, and providing researchers with high-quality human bioresources. The National Biobank of Korea, under the leadership of the Ministry of Health and Welfare, collects specimens through various cohorts and regional biobanks within university hospitals gather specimens from patients. The project began in 2008, and the first phase ended in 2012, which meant that there needed to be a plan for the second phase that begins in 2013. Consequently, professionals from within and outside the project were gathered to develop a plan for the second phase. Under the leadership of the planning committee, six working groups were formed to formulate a practical plan. By conducting two workshops with experts in the six working groups and the planning committee and three forums in 2011 and 2012, they have developed a strategic plan for the second phase of the KBP. This document presents a brief report of the second phase of the project based on a discussion with them. During the first phase of the project (2008-2012), a network was set up between the National Biobank of Korea and 17 biobanks at university-affiliated hospitals in an effort to unify informatics and governance among the participating biobanks. The biobanks within the network manage data on their biospecimens with a unified Biobank Information Management System. Continuous efforts are being made to develop a common standard operating procedure for resource collection, management, distribution, and personal information security, and currently, management of these data is carried out in a somewhat unified manner. In addition, the KBP has trained and educated professionals to work within the

  19. Fourier analysis of RGB fringe-projection profilometry and robust phase-demodulation methods against crosstalk distortion

    CERN Document Server

    Padilla, Moises; Garnica, Guillermo

    2016-01-01

    In this paper we apply the frequency transfer function (FTF) formalism to analyze the red, green and blue (RGB) phase-shifting fringe-projection profilometry technique. The phase-shifted fringe patterns in RGB fringe projection are typically corrupted by crosstalk because the sensitivity curves of most projection-recording systems overlap. Crosstalk distortion needs to be compensated in order to obtain high quality measurements. We study phase-demodulation methods for null/mild, moderate, and severe levels of RGB crosstalk. For null/mild crosstalk, we can estimate the searched phase-map using Bruning's 3-step phase-shifting algorithm (PSA). For moderate crosstalk, the RGB recorded data is usually preprocessed before feeding it into Bruning's PSA; alternatively, in this paper we propose a computationally more efficient approach, which combines crosstalk compensation and phase-demodulation into a single process. For severe RGB crosstalk, we expect non-sinusoidal fringes' profiles (distorting harmonics) and sign...

  20. California Food Processing Industry Wastewater Demonstration Project: Phase I Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Glen; Atkinson, Barbara; Rhyne, Ivin

    2009-09-09

    Wastewater treatment is an energy-intensive process and electricity demand is especially high during the utilities summer peak electricity demand periods. This makes wastewater treatment facilities prime candidates for demand response programs. However, wastewater treatment is often peripheral to food processing operations and its demand response opportunities have often been overlooked. Phase I of this wastewater demonstration project monitored wastewater energy and environmental data at Bell-Carter Foods, Inc., California's largest olive processing plant. For this monitoring activity the project team used Green Energy Management System (GEMS) automated enterprise energy management (EEM) technologies. This report presents results from data collected by GEMS from September 15, 2008 through November 30, 2008, during the olive harvest season. This project established and tested a methodology for (1) gathering baseline energy and environmental data at an industrial food-processing plant and (2) using the data to analyze energy efficiency, demand response, daily peak load management, and environmental management opportunities at the plant. The Phase I goals were to demonstrate the measurement and interrelationship of electricity demand, electricity usage, and water quality metrics and to estimate the associated CO{sub 2} emissions.

  1. Phase-retrieved optical projection tomography for 3D imaging through scattering layers

    Science.gov (United States)

    Ancora, Daniele; Di Battista, Diego; Giasafaki, Georgia; Psycharakis, Stylianos; Liapis, Evangelos; Zacharopoulos, Athanasios; Zacharakis, Giannis

    2016-03-01

    Recently great progress has been made in biological and biomedical imaging by combining non-invasive optical methods, novel adaptive light manipulation and computational techniques for intensity-based phase recovery and three dimensional image reconstruction. In particular and in relation to the work presented here, Optical Projection Tomography (OPT) is a well-established technique for imaging mostly transparent absorbing biological models such as C. Elegans and Danio Rerio. On the contrary, scattering layers like the cocoon surrounding the Drosophila during the pupae stage constitutes a challenge for three dimensional imaging through such a complex structure. However, recent studies enabled image reconstruction through scattering curtains up to few transport mean free paths via phase retrieval iterative algorithms allowing to uncover objects hidden behind complex layers. By combining these two techniques we explore the possibility to perform a three dimensional image reconstruction of fluorescent objects embedded between scattering layers without compromising its structural integrity. Dynamical cross correlation registration was implemented for the registration process due to translational and flipping ambiguity of the phase retrieval problem, in order to provide the correct aligned set of data to perform the back-projection reconstruction. We have thus managed to reconstruct a hidden complex object between static scattering curtains and compared with the effective reconstruction to fully understand the process before the in-vivo biological implementation.

  2. PHASE II CALDERON PROCESS TO PRODUCE DIRECT REDUCED IRON RESEARCH AND DEVELOPMENT PROJECT

    International Nuclear Information System (INIS)

    This project was initially targeted to the making of coke for blast furnaces by using proprietary technology of Calderon in a phased approach, and Phase I was completed. The project was then re-directed to the making of iron units. U.S. Steel teamed up with Calderon for a joint effort which will last 30 months to produce directly reduced iron with the potential of converting it into molten iron (hot metal) consistent with the Roadmap recommendations of 1998 prepared by the Steel Industry in cooperation with the Department of Energy. The work which is labeled as Phase II will take place at two levels; namely, the bench scale level and the process development unit (PDU) level. The bench scale work is being divided into two parts; the construction and operation of Bench Scale No.1 to make hot metal direct as one part and the construction and operation of Bench Scale No.2 to make DRI with its conversion to hot metal as the second part. The work at the PDU consists of getting the PDU which exists ready for advancing the activities from bench scale to PDU level

  3. Coupled geomechanics : reservoir simulation of UTF phase : a project using a full permeability tensor

    Energy Technology Data Exchange (ETDEWEB)

    Du, J.; Wong, R.C.K. [Calgary Univ., AB (Canada)

    2007-07-01

    A coupled geomechanics multiphase flow-heat transfer simulation tool was described. The finite element method (FEM) based tool used a Galerkin's least squares (GLS) method to stabilize the saturation equation. The model was then used to conduct a coupled geomechanics-reservoir simulation of the UTF phase of a steam assisted gravity drainage (SAGD) project. Mathematical equations for thermal fluid flow in porous media included mass balance equations for each fluid phase and Darcy's law. Basic equations for the solid matrix consisted of mass balance equations for the solid matrix, force equilibrium equations and stress-strain relations. A continuum approach was used in which the solid matrix was isotropic with respect to the mechanical properties. Chemical reactions between the solid matrix and fluid phases under non-isothermal conditions were neglected. FE results were compared with measured data from the UTF project. Measured data showed that the steam chambers did not develop uniformly. Field instrumentation responses within geotechnical cross-section reflected 3-D plane strain deformation conditions within the reservoir. Results of the study showed that pore pressure influenced the stress state in the reservoir during the early stages of steam injection. It was concluded that anisotropic strains lead to a 22.5 per cent increase in major principal permeability, and a 9.0 per cent increase in the minor principal permeability within steam chambers. 23 refs., 1 tab., 22 figs.

  4. Phase II Water Rental Pilot Project: Snake River Resident Fish and Wildlife Resources and Management Recommendations.

    Energy Technology Data Exchange (ETDEWEB)

    Stovall, Stacey H.

    1994-08-01

    The Idaho Water Rental Pilot Project was implemented in 1991 as part of the Non-Treaty Storage Fish and Wildlife Agreement between Bonneville Power Administration and the Columbia Basin Fish and Wildlife Authority. The goal of the project is to quantify resident fish and wildlife impacts resulting from salmon flow augmentation releases made from the upper Snake River Basin. Phase I summarized existing resource information and provided management recommendations to protect and enhance resident fish and wildlife habitat resulting from storage releases for the I improvement of an adromous fish migration. Phase II includes the following: (1) a summary of recent biological, legal, and political developments within the basin as they relate to water management issues, (2) a biological appraisal of the Snake River between American Falls Reservoir and the city of Blackfoot to examine the effects of flow fluctuation on fish and wildlife habitat, and (3) a preliminary accounting of 1993--1994 flow augmentation releases out of the upper Snake, Boise, and Payette river systems. Phase III will include the development of a model in which annual flow requests and resident fish and wildlife suitability information are interfaced with habitat time series analysis to provide an estimate of resident fish and wildlife resources.

  5. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Colombia

    International Nuclear Information System (INIS)

    A full report has been released describing the findings of the International Uranium Resources Evaluation Project (IUREP) Orientation Phase Mission to Colombia. The Mission suggests that the speculative uranium resources of the country could be within the very wide range of 20 000 tonnes of 220 000 tonnes of uranium metal. The Mission finds that the area with the highest potential is the Llanos Orientales (Interior Zone), which has the potential of hosting quartz-pebble conglomerate deposits, Proterozoic unconformity-related deposits and sandstone deposits. The Mission recommends that approximately US$80 million should be expended in a phased ten-year exploration programme. It is likely that the majority of the funds will be needed for drilling, followed by ground surveys and airborne radiometry. It is the opinion of the Mission that the considerable funds required for the proposed programme could most suitably be raised by inviting national or foreign commercial organizations to participate under a shared production agreement. (author)

  6. Final waste forms project: Performance criteria for phase I treatability studies

    International Nuclear Information System (INIS)

    This document defines the product performance criteria to be used in Phase I of the Final Waste Forms Project. In Phase I, treatability studies will be performed to provide open-quotes proof-of-principleclose quotes data to establish the viability of stabilization/solidification (S/S) technologies. This information is required by March 1995. In Phase II, further treatability studies, some at the pilot scale, will be performed to provide sufficient data to allow treatment alternatives identified in Phase I to be more fully developed and evaluated, as well as to reduce performance uncertainties for those methods chosen to treat a specific waste. Three main factors influence the development and selection of an optimum waste form formulation and hence affect selection of performance criteria. These factors are regulatory, process-specific, and site-specific waste form standards or requirements. Clearly, the optimum waste form formulation will require consideration of performance criteria constraints from each of the three categories. Phase I will focus only on the regulatory criteria. These criteria may be considered the minimum criteria for an acceptable waste form. In other words, a S/S technology is considered viable only if it meet applicable regulatory criteria. The criteria to be utilized in the Phase I treatability studies were primarily taken from Environmental Protection Agency regulations addressed in 40 CFR 260 through 265 and 268; and Nuclear Regulatory Commission regulations addressed in 10 CFR 61. Thus the majority of the identified criteria are independent of waste form matrix composition (i.e., applicable to cement, glass, organic binders etc.)

  7. Final waste forms project: Performance criteria for phase I treatability studies

    Energy Technology Data Exchange (ETDEWEB)

    Gilliam, T.M. [Oak Ridge National Lab., TN (United States); Hutchins, D.A. [Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States); Chodak, P. III [Massachusetts Institute of Technology (United States)

    1994-06-01

    This document defines the product performance criteria to be used in Phase I of the Final Waste Forms Project. In Phase I, treatability studies will be performed to provide {open_quotes}proof-of-principle{close_quotes} data to establish the viability of stabilization/solidification (S/S) technologies. This information is required by March 1995. In Phase II, further treatability studies, some at the pilot scale, will be performed to provide sufficient data to allow treatment alternatives identified in Phase I to be more fully developed and evaluated, as well as to reduce performance uncertainties for those methods chosen to treat a specific waste. Three main factors influence the development and selection of an optimum waste form formulation and hence affect selection of performance criteria. These factors are regulatory, process-specific, and site-specific waste form standards or requirements. Clearly, the optimum waste form formulation will require consideration of performance criteria constraints from each of the three categories. Phase I will focus only on the regulatory criteria. These criteria may be considered the minimum criteria for an acceptable waste form. In other words, a S/S technology is considered viable only if it meet applicable regulatory criteria. The criteria to be utilized in the Phase I treatability studies were primarily taken from Environmental Protection Agency regulations addressed in 40 CFR 260 through 265 and 268; and Nuclear Regulatory Commission regulations addressed in 10 CFR 61. Thus the majority of the identified criteria are independent of waste form matrix composition (i.e., applicable to cement, glass, organic binders etc.).

  8. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Turkey

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) mission to Turkey. The IUREP Orientation Phase mission to Turkey estimates that the Speculative Resources of that country fall within the range of 21 000 to 55 000 tonnes of uranium. This potential is expected to lie in areas of Neogene and possibly other Tertiary sediments, in particular in the areas of the Menderes Massif and Central Anatolia. The mission describes a proposed exploration programme with expenditures over a five year period of between $80 million and $110 million, with nearly half of the amount being spent on drilling. (author)

  9. Evaluation of the GEM-AQ model in the context of the AQMEII Phase 1 project

    OpenAIRE

    Struzewska, J.; M. Zdunek; Kaminski, J.W.; L. Lobocki; Porebska, M.; Jefimow, M.; Gawuc, L.

    2015-01-01

    In the scope of the AQMEII Phase 1 project the GEM-AQ model was run over Europe for the year 2006. The modelling domain was defined using a global variable resolution grid with a rotated equator and uniform resolution of 0.2° × 0.2° over the European continent. Spatial distribution and temporal variability of the GEM-AQ model results were analysed for surface ozone and PM10 concentrations. Model results were compared with measurements available in the ENSEMBLE d...

  10. Two-Phased Approach to Synchronize the FERC-USACE Processes for Authorizing Non-Federal Hydropower Projects

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-07-01

    Publication summarizing how the United States Army Corps of Engineers (USACE) and Federal Regulatory Energy Commission (FERC) have developed a two-phased, coordinated approach to regulating non-federal hydropower projects.

  11. Supporting innovation. International Project on Innovative Nuclear Reactors and Fuel Cycles moves into first phase

    International Nuclear Information System (INIS)

    energy needs and environmental impact. In order for nuclear energy to play a meaningful role in the global energy supply in the foreseeable future, innovative approaches will be required to address concerns about economic competitiveness, safety, waste and potential proliferation risks.' INPRO's objectives, as defined in the Terms of Reference, are: to help to ensure that nuclear energy is available to contribute in fulfilling, in a sustainable manner, energy needs in the 21st century; to bring together all interested Member States, both technology holders and technology users, to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles that use sound and economically competitive technology, are based - to the extent possible - on systems with inherent safety features and minimise the risk of proliferation and the impact on the environment; to create a process that involves all relevant stake holders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. INPRO is an Agencywide project, with contributions from all relevant IAEA Departments within available resources. The Project will be implemented in two phases. Phase I was initiated in early 2001 and is planned to run to 2003. In the first phase, work will proceed in five subject areas recognized as important for the future development of nuclear energy technology, and on two parallel tracks. Upon successful completion of INPRO's first phase, taking into account advice from the Steering Committee, and with the approval of participating Member States, a second phase of INPRO may be initiated. Drawing on the results from the first phase, it would be directed at: examining in the context of available technologies the feasibility of commencing an international project; and identifying technologies which might be appropriate for

  12. Texas Clean Energy Project: Topical Report, Phase 1 - February 2010-December 2012

    Energy Technology Data Exchange (ETDEWEB)

    Mattes, Karl

    2012-11-01

    Summit Texas Clean Energy, LLC (STCE) is developing the Texas Clean Energy Project (TCEP or the project) to be located near Penwell, Texas. The TCEP will include an Integrated Gasification Combined Cycle (IGCC) plant with a nameplate capacity of 400 megawatts electric (MWe), combined with the production of urea fertilizer and the capture, utilization and storage of carbon dioxide (CO2) sold commercially for regional use in enhanced oil recovery (EOR) in the Permian Basin of west Texas. The TCEP will utilize coal gasification technology to convert Powder River Basin subbituminous coal delivered by rail from Wyoming into a synthetic gas (syngas) which will be cleaned and further treated so that at least 90 percent of the overall carbon entering the facility will be captured. The clean syngas will then be divided into two high-hydrogen (H2) concentration streams, one of which will be combusted as a fuel in a combined cycle power block for power generation and the other converted into urea fertilizer for commercial sale. The captured CO2 will be divided into two streams: one will be used in producing the urea fertilizer and the other will be compressed for transport by pipeline for offsite use in EOR and permanent underground sequestration. The TCEP was selected by the U.S. Department of Energy (DOE) Office of Fossil Energy (FE) for cost-shared co-funded financial assistance under Round 3 of its Clean Coal Power Initiative (CCPI). A portion of this financial assistance was budgeted and provided for initial development, permitting and design activities. STCE and the DOE executed a Cooperative Agreement dated January 29, 2010, which defined the objectives of the project for all phases. During Phase 1, STCE conducted and completed all objectives defined in the initial development, permitting and design portions of the Cooperative Agreement. This topical report summarizes all work associated with the project objectives, and additional work

  13. SLUDGE TREATMENT PROJECT PHASE 1 SLUDGE STORAGE OPTIONS ASSESSMENT OF T PLANT VERSUS ALTERNATE STORAGE FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    RUTHERFORD WW; GEUTHER WJ; STRANKMAN MR; CONRAD EA; RHOADARMER DD; BLACK DM; POTTMEYER JA

    2009-04-29

    The CH2M HILL Plateau Remediation Company (CHPRC) has recommended to the U.S. Department of Energy (DOE) a two phase approach for removal and storage (Phase 1) and treatment and packaging for offsite shipment (Phase 2) of the sludge currently stored within the 105-K West Basin. This two phased strategy enables early removal of sludge from the 105-K West Basin by 2015, allowing remediation of historical unplanned releases of waste and closure of the 100-K Area. In Phase 1, the sludge currently stored in the Engineered Containers and Settler Tanks within the 105-K West Basin will be transferred into sludge transport and storage containers (STSCs). The STSCs will be transported to an interim storage facility. In Phase 2, sludge will be processed (treated) to meet shipping and disposal requirements and the sludge will be packaged for final disposal at a geologic repository. The purpose of this study is to evaluate two alternatives for interim Phase 1 storage of K Basin sludge. The cost, schedule, and risks for sludge storage at a newly-constructed Alternate Storage Facility (ASF) are compared to those at T Plant, which has been used previously for sludge storage. Based on the results of the assessment, T Plant is recommended for Phase 1 interim storage of sludge. Key elements that support this recommendation are the following: (1) T Plant has a proven process for storing sludge; (2) T Plant storage can be implemented at a lower incremental cost than the ASF; and (3) T Plant storage has a more favorable schedule profile, which provides more float, than the ASF. Underpinning the recommendation of T Plant for sludge storage is the assumption that T Plant has a durable, extended mission independent of the K Basin sludge interim storage mission. If this assumption cannot be validated and the operating costs of T Plant are borne by the Sludge Treatment Project, the conclusions and recommendations of this study would change. The following decision-making strategy, which is

  14. SLUDGE TREATMENT PROJECT PHASE 1 SLUDGE STORAGE OPTIONS. ASSESSMENT OF T PLANT VERSUS ALTERNATE STORAGE FACILITY

    International Nuclear Information System (INIS)

    The CH2M HILL Plateau Remediation Company (CHPRC) has recommended to the U.S. Department of Energy (DOE) a two phase approach for removal and storage (Phase 1) and treatment and packaging for offsite shipment (Phase 2) of the sludge currently stored within the 105-K West Basin. This two phased strategy enables early removal of sludge from the 105-K West Basin by 2015, allowing remediation of historical unplanned releases of waste and closure of the 100-K Area. In Phase 1, the sludge currently stored in the Engineered Containers and Settler Tanks within the 105-K West Basin will be transferred into sludge transport and storage containers (STSCs). The STSCs will be transported to an interim storage facility. In Phase 2, sludge will be processed (treated) to meet shipping and disposal requirements and the sludge will be packaged for final disposal at a geologic repository. The purpose of this study is to evaluate two alternatives for interim Phase 1 storage of K Basin sludge. The cost, schedule, and risks for sludge storage at a newly-constructed Alternate Storage Facility (ASF) are compared to those at T Plant, which has been used previously for sludge storage. Based on the results of the assessment, T Plant is recommended for Phase 1 interim storage of sludge. Key elements that support this recommendation are the following: (1) T Plant has a proven process for storing sludge; (2) T Plant storage can be implemented at a lower incremental cost than the ASF; and (3) T Plant storage has a more favorable schedule profile, which provides more float, than the ASF. Underpinning the recommendation of T Plant for sludge storage is the assumption that T Plant has a durable, extended mission independent of the K Basin sludge interim storage mission. If this assumption cannot be validated and the operating costs of T Plant are borne by the Sludge Treatment Project, the conclusions and recommendations of this study would change. The following decision-making strategy, which is

  15. The Barselina Project Phase 4 Summary report. Ignalina Unit 2 Probabilistic Safety Analysis

    International Nuclear Information System (INIS)

    The Barselina Project was initiated in the summer of 1991. The project is a multilateral co-operation between Lithuania, Russia and Sweden. The long range objective is to establish common perspectives and unified bases for assessment of severe accident risks and needs for remedial measures for the RBMK reactors. The Swedish BWR Barsebaeck is used as reference plant and the Lithuanian RBMK Ignalina as application plant. During phase 3, from March, 1993 to June, 1994, a full scope Probabilistic Safety Analysis (PSA) model of the Ignalina Nuclear Power Plant unit 2 (INPP-2) was developed to identify possible safety improvement of risk importance. The probabilistic methodology was applied on a plant specific basis for a channel type reactor of RBMK design. To increase the realism of the risk model a set of deterministic analyses were performed and plant/RBMK-specific data bases were developed and used. A general concept for analysing this type of reactor was developed. During phase 4, July 1994 to September 1996, the PSA was further developed, taking into account plant changes, improved modeling methods and extended plant information concerning dependencies (area events, dynamic effects, electrical and signal dependencies). The updated model is quantified and new results and conclusions are evaluated

  16. Quantification of 2-acetyl-1-pyrroline in rice by stable isotope dilution assay through headspace solid-phase microextraction coupled to gas chromatography-tandem mass spectrometry

    International Nuclear Information System (INIS)

    A new and convenient synthesis of 2-acetyl-1-pyrroline (2AP), a potent flavor compound in rice, and its ring-deuterated analog, 2-acetyl-1-d2-pyrroline (2AP-d2), was reported. A stable isotope dilution assay (SIDA), involving headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-positive chemical ionization-ion trap-tandem mass spectrometry (GC-PCI-IT-MS-MS), was developed for 2AP quantification. A divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber was used for HS-SPME procedure and parameters affecting analytes recovery, such as extraction time and temperature, pH and salt, were studied. The repeatability of the method (n = 10) expressed as relative standard deviation (RSD) was 11.6%. A good linearity was observed from 5.9 to 779 ng of 2AP (r2 = 0.9989). Limits of detection (LOD) and quantification (LOQ) for 2AP were 0.1 and 0.4 ng g-1 of rice, respectively. The recovery of spiked 2AP from rice matrix was almost complete. The developed method was applied to the quantification of 2AP in aerial parts and grains of scented and non-scented rice cultivars.

  17. Analysis of benzo[a]pyrene in vegetable oils using molecularly imprinted solid phase extraction (MISPE) coupled with enzyme-linked immunosorbent assay (ELISA).

    Science.gov (United States)

    Pschenitza, Michael; Hackenberg, Rudolf; Niessner, Reinhard; Knopp, Dietmar

    2014-01-01

    This paper describes the development of a molecularly imprinted polymer-based solid phase extraction (MISPE) method coupled with enzyme-linked immunosorbent assay (ELISA) for determination of the PAH benzo[a]pyrene (B[a]P) in vegetable oils. Different molecularly imprinted polymers (MIPs) were prepared using non-covalent 4-vinylpyridine/divinylbenzene co-polymerization at different ratios and dichloromethane as porogen. Imprinting was done with a template mixture of phenanthrene and pyrene yielding a broad-specific polymer for PAHs with a maximum binding capacity (Q) of ~32 μg B[a]P per 50 mg of polymer. The vegetable oil/n-hexane mixture (1:1, (v/v)) was pre-extracted with acetonitrile, the solvent evaporated, the residue reconstituted in n-hexane and subjected to MISPE. The successive washing with n-hexane and isopropanol revealed most suitable to remove lipid matrix constituents. After elution of bound PAHs from MISPE column with dichloromethane, the solvent was evaporated, the residue reconstituted with dimethyl sulfoxide and diluted 100-fold with methanol/water (10:90, (v/v)) for analysis of B[a]P equivalents with an ELISA. The B[a]P recovery rates in spiked vegetable oil samples of different fatty acid composition were determined between 63% and 114%. The presence of multiple PAHs in the oil sample, because of MIP selectivity and cross-reactivity of the ELISA, could yield overestimated B[a]P values. PMID:24887045

  18. Analysis of Benzo[a]pyrene in Vegetable Oils Using Molecularly Imprinted Solid Phase Extraction (MISPE Coupled with Enzyme-Linked Immunosorbent Assay (ELISA

    Directory of Open Access Journals (Sweden)

    Michael Pschenitza

    2014-05-01

    Full Text Available This paper describes the development of a molecularly imprinted polymer-based solid phase extraction (MISPE method coupled with enzyme-linked immunosorbent assay (ELISA for determination of the PAH benzo[a]pyrene (B[a]P in vegetable oils. Different molecularly imprinted polymers (MIPs were prepared using non-covalent 4-vinylpyridine/divinylbenzene co-polymerization at different ratios and dichloromethane as porogen. Imprinting was done with a template mixture of phenanthrene and pyrene yielding a broad-specific polymer for PAHs with a maximum binding capacity (Q of ~32 μg B[a]P per 50 mg of polymer. The vegetable oil/n-hexane mixture (1:1, (v/v was pre-extracted with acetonitrile, the solvent evaporated, the residue reconstituted in n-hexane and subjected to MISPE. The successive washing with n-hexane and isopropanol revealed most suitable to remove lipid matrix constituents. After elution of bound PAHs from MISPE column with dichloromethane, the solvent was evaporated, the residue reconstituted with dimethyl sulfoxide and diluted 100-fold with methanol/water (10:90, (v/v for analysis of B[a]P equivalents with an ELISA. The B[a]P recovery rates in spiked vegetable oil samples of different fatty acid composition were determined between 63% and 114%. The presence of multiple PAHs in the oil sample, because of MIP selectivity and cross-reactivity of the ELISA, could yield overestimated B[a]P values.

  19. Quantification of 2-acetyl-1-pyrroline in rice by stable isotope dilution assay through headspace solid-phase microextraction coupled to gas chromatography-tandem mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Maraval, Isabelle [UMR Qualisud, CIRAD, 73 Rue J. F. Breton, 34398 Montpellier Cedex 5 (France); UMR Qualisud, Universite Montpellier 2, place E. Bataillon, 34095 Montpellier Cedex 5 (France); Sen, Kemal [Department of Food Engineering, Faculty of Agriculture, University of Cukurova, 01330 Adana (Turkey); Agrebi, Abdelhamid; Menut, Chantal; Morere, Alain [UMR 5247, Institut des Biomolecules Max Mousseron (IBMM), CNRS, Universites Montpellier 2 et 1, Ecole Nationale Superieure de Chimie de Montpellier, 8 Rue de l' Ecole Normale, 34296 Montpellier Cedex 5 (France); Boulanger, Renaud [UMR Qualisud, CIRAD, 73 Rue J. F. Breton, 34398 Montpellier Cedex 5 (France); Gay, Frederic [CIRAD, DORAS Centre, Research and Development Building, Kasetsart University, Bangkok 10900 (Thailand); Mestres, Christian [UMR Qualisud, CIRAD, 73 Rue J. F. Breton, 34398 Montpellier Cedex 5 (France); Gunata, Ziya, E-mail: zgunata@univ-montp2.fr [UMR Qualisud, Universite Montpellier 2, place E. Bataillon, 34095 Montpellier Cedex 5 (France)

    2010-08-24

    A new and convenient synthesis of 2-acetyl-1-pyrroline (2AP), a potent flavor compound in rice, and its ring-deuterated analog, 2-acetyl-1-d{sub 2}-pyrroline (2AP-d{sub 2}), was reported. A stable isotope dilution assay (SIDA), involving headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-positive chemical ionization-ion trap-tandem mass spectrometry (GC-PCI-IT-MS-MS), was developed for 2AP quantification. A divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber was used for HS-SPME procedure and parameters affecting analytes recovery, such as extraction time and temperature, pH and salt, were studied. The repeatability of the method (n = 10) expressed as relative standard deviation (RSD) was 11.6%. A good linearity was observed from 5.9 to 779 ng of 2AP (r{sup 2} = 0.9989). Limits of detection (LOD) and quantification (LOQ) for 2AP were 0.1 and 0.4 ng g{sup -1} of rice, respectively. The recovery of spiked 2AP from rice matrix was almost complete. The developed method was applied to the quantification of 2AP in aerial parts and grains of scented and non-scented rice cultivars.

  20. Hangzhou Jinjiang Group Shanxi Fusheng Aluminum Phase I 800,000 t/a Aluminum Oxide Project Started Operation

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>On October 19,the Shanxi Province Pinglu County Phase I 800,000t/a Aluminum Oxide Project of Shanxi Fusheng Aluminum Co.,Ltd,a subordinate of Hangzhou Jinjiang Group,started operation.This is the fourth Aluminum oxide project constructed and operated by Jinjiang Group.

  1. FALSIRE phase 2: CSNI project for fracture analyses of large- scale international reference experiments

    International Nuclear Information System (INIS)

    A summary of Phase II of the Project for Fracture Analysis of Large-Scale International Reference Experiments (FALSIRE) is presented. FALSIRE I was initiated by the CSNI/FAG in 1988 to assess various fracture methodologies through interpretive analyses of six large-scale fracture experiments. Following the successful completion of FALSIRE I in 1992, several participating organizations indicated a desire to proceed with further evaluation of fracture analysis methods in a Phase II program. FALSIRE II included seven reference cleavage fracture experiments that focused primarily on behavior of relatively shallow cracks in the transition temperature region. Included were experiments for which cracks showed either unstable extension or two stages of extension (e.g., stable crack extension followed by unstable extension) under transient thermal and mechanical loadings. Also, crack initiation was investigated in connection with clad surfaces and with biaxial loading conditions. A comparative assessment and discussion of the analysis results are presented in the report. Generally, structural responses of the test specimens were predicted with tolerable scatter bands; these represent a marked improvement over the results achieved in the initial phase (FALSIRE I). The analyses revealed that the loss-of-constraint effects observed in specific cases require a second (or dual) fracture parameter to be introduced into the fracture model to characterize crack-tip conditions. Additional toughness data obtained from a range of specimen geometries and constraint conditions are required to validate these dual-parameter cleavage fracture methodologies. Finally, proposals for future work in the context of cooperative international analytical projects similar to FALSIRE are provided

  2. Balancing between freedom and control - Leadership roles of a new product development project leader at different phases of innovation process

    OpenAIRE

    Luukkonen, Satu

    2010-01-01

    Research Objectives In the success of innovation, leadership plays an important role. Project leader is usually responsible in managing the innovation process as well as the people in the team. The innovation process consists of phases that are very different by nature and hence, leadership practices applicable for the development phase may not be applicable for the front end phase. Thus, leaders of an innovative team need to balance between different kinds of roles and functions during t...

  3. The Geoengineering Model Intercomparison Project Phase 6 (GeoMIP6). Simulation Design and Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Kravitz, Benjamin S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Robock, Alan [Rutgers Univ., New Brunswick, NJ (United States); Tilmes, S. [National Center for Atmospheric Research, Boulder, CO (United States); Boucher, Olivier [Laboratoire de Meteorologie Dynamique, Paris (France); English, J. [NOAA Earth System Research Lab. and Univ. of Colorado, Boulder, CO (United States); Irvine, Peter [Inst. of Advanced Sustainability Studies, Potsdam (Germany); Jones, Andrew [Met Office Hadley Centre, Exeter (United Kingdom); Lawrence, M. G. [Inst. of Advanced Sustainability Studies, Potsdam (Germany); Maccracken, Michael C. [Climate Inst., Washington, DC (United States); Muri, Helene O. [Univ. of Oslo (Norway); Moore, John [Beijing Normal Univ., Beijing (China); Niemeier, Ulrike [Max Planck Inst. for Meterology, Hamburg (Germany); Phipps, Steven [Univ. of New South Wales, Sydney, NSW (Australia); Sillmann, Jana [Center for International Climate and Environmental Research, Oslo (Norway); Storelvmo, Trude [Yale Univ., New Haven, CT (United States); Wang, Hailong [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Watanabe, Shingo [Japan Agency for Marine-Earth Science and Technology, Yokohama (Japan)

    2015-10-27

    We present a suite of new climate model experiment designs for the Geoengineering Model Intercomparison Project (GeoMIP). This set of experiments, named GeoMIP6 (to be consistent with the Coupled Model Intercomparison Project Phase 6), builds on the previous GeoMIP project simulations, and has been expanded to address several further important topics, including key uncertainties in extreme events, the use of geoengineering as part of a portfolio of responses to climate change, and the relatively new idea of cirrus cloud thinning to allow more longwave radiation to escape to space. We discuss experiment designs, as well as the rationale for those designs, showing preliminary results from individual models when available. We also introduce a new feature, called the GeoMIP Testbed, which provides a platform for simulations that will be performed with a few models and subsequently assessed to determine whether the proposed experiment designs will be adopted as core (Tier 1) GeoMIP experiments. This is meant to encourage various stakeholders to propose new targeted experiments that address their key open science questions, with the goal of making GeoMIP more relevant to a broader set of communities.

  4. The Greenhouse Gas Project Of ESA's Climate Change Initiative (GHG-CCI): Phase 1 Achievements

    Science.gov (United States)

    Buchwitz, M.; Reuter, M.; Schneising, O.; Boesch, H.; Aben, I.; Armante, R.; Bergamaschi, P.; Blumenstock, T.; Bovensmann, H.; Brunner, D.; Buchmann, B.; Burrows, J. P.; Butz, A.; Chevallier, F.; Crevoisier, C. D.; Detmers, R.; Deutcher, N.; Dils, B.; Frankenberg, C.; Guerlet, S.; Hasekamp, O. P.; Heymann, J.; Kaminski, T.; Laeng, A.; Lichtenberg, G.; De Maziere, M.; Noel, S.; Notholt, J.; Parker, R.; Scholze, M.; Sussmann, R.; Stiller, G. P.; Warneke, T.; Zehner, C.

    2013-12-01

    The GHG-CCI project (http://www.esa-ghg-cci.org) is one of several projects of ESA's Climate Change Initiative (CCI, http://www.esa-cci.org/), which delivers data sets of various Essential Climate Variables (ECVs). The goal of GHG-CCI is to generate global satellite-derived data sets of the two important anthropogenic greenhouse gases (GHG) carbon dioxide (CO2) and methane (CH4) with a quality as needed to derive information on regional CO2 and CH4 surface sources and sinks. A good understanding of GHG sources and sinks is a pre-requisite for reliable climate prediction. The GHG-CCI core ECV data products are near-surface sensitive column-averaged dry air mole fractions of CO2 and CH4, denoted XCO2 and XCH4, retrieved from SCIAMACHY/ENVISAT and TANSO- FTS/GOSAT. Other satellite instruments such as IASI and MIPAS are also used as they provide additional information about the two GHGs. Here we present an overview of Phase 1 of the GHG-CCI project (Sept.2010 - Dec.2013), focusing on scientific achievements and on the “Climate Research Data Package” (CRDP), which is the first version of the ECV GHG data base.

  5. The Geoengineering Model Intercomparison Project Phase 6 (GeoMIP6: simulation design and preliminary results

    Directory of Open Access Journals (Sweden)

    B. Kravitz

    2015-10-01

    Full Text Available We present a suite of new climate model experiment designs for the Geoengineering Model Intercomparison Project (GeoMIP. This set of experiments, named GeoMIP6 (to be consistent with the Coupled Model Intercomparison Project Phase 6, builds on the previous GeoMIP project simulations, and has been expanded to address several further important topics, including key uncertainties in extreme events, the use of geoengineering as part of a portfolio of responses to climate change, and the relatively new idea of cirrus cloud thinning to allow more longwave radiation to escape to space. We discuss experiment designs, as well as the rationale for those designs, showing preliminary results from individual models when available. We also introduce a new feature, called the GeoMIP Testbed, which provides a platform for simulations that will be performed with a few models and subsequently assessed to determine whether the proposed experiment designs will be adopted as core (Tier 1 GeoMIP experiments. This is meant to encourage various stakeholders to propose new targeted experiments that address their key open science questions, with the goal of making GeoMIP more relevant to a broader set of communities.

  6. Construction and operation of a Double Phase LAr Large Electron Multiplier Time Projection Chamber

    CERN Document Server

    Badertscher, A; Laffranchi, M; Marchionni, A; Natterer, G; Otiougova, P; Resnati, F; Rubbia, A

    2008-01-01

    We successfully operated a novel kind of LAr Time Projection Chamber based on a Large Electron Multiplier (LEM) readout system. The prototype, of about 3 liters active volume, is operated in liquid-vapour (double) phase pure Ar. The ionization electrons, after drifting in the LAr volume, are extracted by a set of grids into the gas phase and driven into the holes of a double stage LEM, where charge amplification occurs. Each LEM is a thick macroscopic hole multiplier of 10x10 cm$^2$ manufactured with standard PCB techniques. The electrons signal is readout via two orthogonal coordinates, one using the induced signal on the segmented upper electrode of the LEM itself and the other by collecting the electrons on a segmented anode. Custom-made preamplifiers have been especially developed for this purpose. Cosmic ray tracks have been successfully observed in pure gas at room temperature and in double phase Ar operation. We believe that this proof of principle represents an important milestone in the realization o...

  7. Air pathway report: Phase I of the Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    1991-07-01

    Phase 1 of the air-pathway portion of the Hanford Environmental Dose Reconstruction (HEDR) Project sought to determine whether dose estimates could be calculated for populations in the 10 counties nearest the Hanford Site from atmospheric releases of iodine-131 from the site from 1944--1947. Phase 1 demonstrated the following: HEDR-calculated source-term estimates of iodine-131 releases to the atmosphere were within 20% of previously published estimates; calculated vegetation concentrations of iodine-131 agree well with previously published measurements; the highest of the Phase 1 preliminary dose estimates to the thyroid are consistent with independent, previously published estimates of doses to maximally exposed individuals; and, relatively crude, previously published measurements of thyroid burdens for Hanford workers are in the range of average burdens that the HEDR model estimated for similar reference individuals'' for the period 1944--1947. Preliminary median dose estimates summed over the year 1945--1947 for the primary pathway, air-pasture-cow-milk-thyroid, ranged from low median values of 0.006 rad for upwind adults who obtained milk from backyard cows not on pasture to high median values of 68.0 rad for downwind infants who drank milk from pasture-fed cows. Extremes of the estimated range are a low of essentially zero to upwind adults and a high of almost 3000 rem to downwind infants. 37 refs., 37 figs., 2 tabs.

  8. Hydrogeological characterization on surface-based investigation phase in the Mizunami underground research laboratory project, in Japan

    International Nuclear Information System (INIS)

    The Mizunami Underground Research Laboratory (MIU) project is being carried out by Japan Atomic Energy Agency in the Cretaceous Toki granite in the Tono area, central Japan. The MIU project is a purpose-built generic underground research laboratory project that is planned for a broad scientific study of the deep geological environment as a basis of research and development for geological disposal of nuclear wastes. One of the main goals of the MIU project is to establish comprehensive techniques for investigation, analysis, and assessment of the deep geological environment. The MIU project has three overlapping phases: Surface-based Investigation (Phase I), Construction (Phase II) and Operation (Phase III). Hydrogeological investigations using a stepwise process in Phase I have been carried out in order to obtain information on important properties such as, location of water conducting features, hydraulic conductivity and so on. Hydrogeological modeling and groundwater flow simulations in Phase I have been carried out in order to synthesize these investigation results, to evaluate the uncertainty of the hydrogeological model and to identify the main issues for further investigations. Using the stepwise hydrogeological characterization approach and combining the investigation with modeling and simulation, understanding of the hydrogeological environment has been progressively improved. (authors)

  9. The Convergence of Heat, Groundwater & Fracture Permeability. Innovative Play Fairway Modelling Applied to the Tularosa Basin Phase 1 Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, Carlon R. [Ruby Mountain Inc., Salt Lake City, UT (United States); Nash, Gregory D. [Univ. of Utah, Salt Lake City, UT (United States). Energy & Geoscience Institute; Sorkhabi, Rasoul [Univ. of Utah, Salt Lake City, UT (United States). Energy & Geoscience Institute; Moore, Joseph [Univ. of Utah, Salt Lake City, UT (United States). Energy & Geoscience Institute; Simmons, Stuart [Univ. of Utah, Salt Lake City, UT (United States). Energy & Geoscience Institute; Brandt, Adam [Univ. of Utah, Salt Lake City, UT (United States). Energy & Geoscience Institute; Barker, Benjamin [Univ. of Utah, Salt Lake City, UT (United States). Energy & Geoscience Institute; Swanson, Brigitte [Ruby Mountain Inc., Salt Lake City, UT (United States)

    2015-10-16

    This report summarizes the activities and key findings of the project team occurring during Phase 1 (August 2014-October 2015) of the Tularosa Basin Geothermal Play Fairway Analysis Project. The Tularosa Basin Play Fairway Analysis (PFA) project tested two distinct geothermal exploration methodologies covering the entire basin within South Central New Mexico and Far West Texas. Throughout the initial phase of the project, the underexplored basin proved to be a challenging, yet ideal test bed to evaluate effectiveness of the team’s data collection techniques as well as the effectiveness of our innovative PFA. Phase 1 of the effort employed a low-cost, pragmatic approach using two methods to identify potential geothermal plays within the study area and then compared and contrasted the results of each method to rank and evaluate potential plays. Both methods appear to be very effective and highly transferable to other areas.

  10. Phase 1 Final status survey plan for the West Valley demonstration project.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R. L. (Environmental Science Division)

    2011-05-31

    This plan provides the technical basis and associated protocols to support Phase 1 final status survey (FSS) data collection and interpretation as part of the West Valley Demonstration Project Phase 1 Decommissioning Plan process. This plan is consistent with the Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM). The Phase 1 Decommissioning Plan provides the relevant derived concentration guideline levels (DCGLs) for the Phase 1 radionuclides of interest. This plan includes protocols that will be applied to the deep excavations planned for Waste Management Area (WMA) 1 and WMA 2, for surface soils outside the WMA 1 and WMA 2 excavations that do not have contamination impacts at depths greater than one meter, and for areas that are used for Phase 1 contaminated soil lay-down purposes. All excavated and lay-down areas will be classified as MARSSIM Class 1 areas. Surface soils that have not been excavated, are not expected to exceed DCGLs, and do not have contamination impacts at depths greater than one meter will be divided into either Class 1 or Class 2 areas depending on the expected potential for surface soil contamination in those areas. The plan uses gamma scans combined with biased soil samples to address DCGLemc concerns. The plan uses systematic soil sampling combined with area factors to address DCGLw and DCGLemc concerns. The Sign test will be used to statistically evaluate DCGLw compliance. If the results from the characterization sampling and analysis plan (CSAP) data collection indicate that background may be a significant issue for Sign test implementation, the Wilcoxon rank sum (WRS) test will be used instead to demonstrate DCGLw compliance. A reference area will be selected on the basis of CSAP data results if the WRS test becomes a necessity. The WMA 1 excavation footprint includes approximately 476 foundation pilings that will be trimmed and left in place. Piling-specific systematic and biased sampling will be conducted to

  11. A Correlational Study of Seven Projective Spatial Structures with Regard to the Phases of the MOON^

    Science.gov (United States)

    Wellner, Karen Linette

    1995-01-01

    This study investigated the relationship between projective spatial structures and the ability to construct a scientific model. In addition, gender-related performance and the influence of prior astronomy experience on task success were evaluated. Sixty-one college science undergraduates were individually administered Piagetian tasks to assess for projective spatial structures and the ability to set up a phases of the moon model. The spatial tasks included: (a) Mountains task (coordination of perspectives); (b) Railroad task (size and intervals of objects with increasing distance); (c) Telephone Poles task (masking and ordering objects); and (d) Shadows task (spatial relationships between an object and its shadow, dependent upon the object's orientation). Cramer coefficient analyses indicated that significant relationships existed between Moon task and spatial task success. In particular, the Shadows task, requiring subjects to draw shadows of objects in different orientations, proved most difficult and was most strongly associated with with a subject's understanding of lunar phases. Chi-square tests for two independent samples were used to analyze gender performance differences on each of the Ave tasks. Males performed significantly better at a.05 significance level in regard to the Shadows task and the Moon task. Chi-square tests for two independent samples showed no significant difference in Moon task performance between subjects with astronomy or Earth science coursework, and those without such science classroom experience. Overall, only six subjects passed all seven projective spatial structure tasks. Piaget (1967) contends that concrete -operational spatial structures must be established before an individual is able to develop formal-operational patterns of thinking. The results of this study indicate that 90% of the interviewed science majors are still operating at the concrete-operational level. Several educational implications were drawn from this study

  12. Low Energy Nuclear Reaction Aircraft- 2013 ARMD Seedling Fund Phase I Project

    Science.gov (United States)

    Wells, Douglas P.; McDonald, Robert; Campbell, Robbie; Chase, Adam; Daniel, Jason; Darling, Michael; Green, Clayton; MacGregor, Collin; Sudak, Peter; Sykes, Harrison; Waddington, Michael; Fredericks, William J.; Lepsch, Roger A.; Martin, John G.; Moore, Mark D.; Zawodny, Joseph M.; Felder, James L.; Snyder, Christopher A.

    2014-01-01

    This report serves as the final written documentation for the Aeronautic Research Mission Directorate (ARMD) Seedling Fund's Low Energy Nuclear Reaction (LENR) Aircraft Phase I project. The findings presented include propulsion system concepts, synergistic missions, and aircraft concepts. LENR is a form of nuclear energy that potentially has over 4,000 times the energy density of chemical energy sources. It is not expected to have any harmful emissions or radiation which makes it extremely appealing. There is a lot of interest in LENR, but there are no proven theories. This report does not explore the feasibility of LENR. Instead, it assumes that a working system is available. A design space exploration shows that LENR can enable long range and high speed missions. Six propulsion concepts, six missions, and four aircraft concepts are presented. This report also includes discussion of several issues and concerns that were uncovered during the study and potential research areas to infuse LENR aircraft into NASA's aeronautics research.

  13. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Madagascar

    International Nuclear Information System (INIS)

    A report has recently been made public which describes the findings of the International Uranium Resources Evaluation Project (IUREP) Mission to Madagascar. The IUREP Orientation Phase Mission to Madagascar estimates the Speculative Resources of that country to be within the wide range of 4 000 to 38 000 tonnes uranium. Such resources could lie in areas with known occurrences (uranothorianite, Ft. Dauphin up to 5 000 t U, i.e. 'pegmatoids'; uranocircite, Antsirabe up to 3 000 t U in Neogene sediments; carnotiteautonite, Karoo area up to 30 000 t U in sandstones and in areas with as yet untested environments (e.g. related to unconformities and calcretes). Modifications to existing uranium exploration programmes are suggested and policy alternatives reviewed. No specific budget is proposed. (author)

  14. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Rwanda

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) Mission to Rwanda. The IUREP Orientation Phase Mission to Rwanda estimates that the Speculative Resources of that country fall within the range of 500 to 5 000 tonnes of uranium. The majority of this potential is expected to be located in the Precambrian Ruzizian, especially in conjunction with tectonized pegmatoidal remobilizations of metamorphic sediments of western Rwanda. Other favourable geological environments include lamprophyric dikes and post tectonic granites of central Rwanda. The Mission recommends that over a period of five years approximately US$4.2 million be spent on exploration in Rwanda. The majority of this would be spent on airborne and ground geophysical surveys ($1.5 million) and exploration drilling ($1 million). Prospecting, trenching and tunneling and analytical work would require the remainder of the $4.2 million ($1.7 million). (author)

  15. Design and assembly of the optical modules for phase-2 of the NEMO project

    International Nuclear Information System (INIS)

    The NEMO collaboration team has undertaken a Phase-2 project, which aims at the realization and installation of a new infrastructure at the Capo Passero (Italy) deep-sea site at a depth of 3500 m. With this objective in mind, a fully equipped tower with 8-storey hosting two optical modules at each end is under construction. Following a well established procedure, 32 optical modules have been assembled. The optical module consists of a large area photomultiplier tube enclosed in a pressure resistant glass sphere with a diameter of 13 in. The photomultiplier is a R7081 type, produced by Hamamatsu, with a photocathode area with a diameter of 10 in. and 10 dynodes. Mechanical and optical contacts between the front of the photomultiplier tube and the glass surface are ensured by an optical bi-component silicone gel. A mu-metal cage is used to shield the photomultiplier against the influence of the Earth's magnetic field

  16. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Cameroon

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) Mission to Cameroon. The IUREP Orientation Phase Mission to Cameroon estimates the Speculative Resources of that country to be in the order of 10 000 tonnes uranium for syenite-associated U-deposits in southern Cameroon, and in the order of 5 000 tonnes uranium for uranium deposits associated with albitized and desilicified late tectonic Panafrican granites (episyenite) and Paleozoic volcanics in northern Cameroon. No specific tonnage is given for Francevillian equivalents (DJA-Series) and for Mesozoic and Cenozoic sedimentary basins, which are thought to hold limited potential for sandstone hosted uranium. However the Douala basin, consisting of mixed marine and continental sequences merits some attention. No specific budget and programme for uranium exploration are proposed for Cameroon. Instead specific recommendations concerning specific potential environments and general recommendation concerning the methodology of exploration are made. (author)

  17. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Burundi

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) Mission to Burundi. The IUREP Orientation Phase Mission to Burundi estimates that the Speculative Resources of that country fall within the range of 300 to more than 4 100 tonnes of uranium. The potential is rather evenly distributed throughout the Proterozoic of Burundi in various geological environments (unconformity, hydrothermal, fault controlled, etc.). The mission recommends that over a period of five years U.S. $ 3 to 4.5 million be spent on exploration in Burundi, with even spending on the various exploration techniques as e.g. prospecting, drilling trenching, geophysical surveys, analyses, etc. (author)

  18. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Peru

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (TUREP) Mission to Peru. The IUREP Orientation Phase Mission to Peru estimates that the Speculative Resources of that country fall within the range of 6 000 to 11 000 tonnes uranium. The majority of this potential is expected to be located in Late Tertiary ignimbrites and associated sediments in the high Andes of southern Peru. Other favourable geological environments include calcretes, developed from Tertiary volcanogenic sources over the Precambrian in the Pacific Coastal desert in southern Peru, and Hercynian subvolcanic granites in the eastern Cordillera of southern Peru. The Mission recommends that over a period of five years approximately U.S. $10 million be spent on exploration in Peru. The majority of this would be spent on drilling ($5 million) and tunnelling ($2 million) with an additional $3 million on surface and airborne radiometric surveys. (author)

  19. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Uganda

    International Nuclear Information System (INIS)

    A full report has been compiled describing the findings of the International Uranium Resources Evaluation Project (IUREP) Orientation Phase Mission to Uganda. The Mission suggest that the speculative uranium resources of the country could be within the very wide range of 0 to 105 000 tonnes of uranium metal. The Mission finds that most of these speculative resources are related to Proterozoic unconformities and to Cenozoic sandstones of the Western Rift Valley. Some potential is also associated with Post-tectonic granites. The Mission recommends to rehabilitate the Geological Survey of Uganda in order to enable it to conduct and support a uranium exploration programme for unconformity related and for standstone hosted uranium deposits. Recommended exploration methods encompass geological mapping and compilation, an airborne gamma-ray spectrometer survey north of 1 deg. North latitude, stream sediment sampling, and ground scintillometric surveys in favourable areas. Follow up work should include VLF-EM surveys, emanometry and drilling. (author)

  20. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Bolivia

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) mission to Bolivia. The IUREP Orientation Phase mission to Bolivia estimates that the Speculative Uranium Resources of that country fall within the range of 100 to 107 500 tonnes uranium. The majority of this potential is expected to be located in the Precambrian crystalline and sedimentary rocks of the southwestern part of the Central Brazilian Shield. Other potentially favourable geologic environments include Palaeozoic two mica granites and their metasedimentary hosts, Mesozoic granites and granodiorites as well as the intruded formations and finally Tertiary acid to intermediate volcanics. The mission recommends that approximately US$ 13 million be spent on exploration in Bolivia over a five-year period. The majority of this expenditure would be for airborne and surface exploration utilising geologic, magnetometric, radiometric, and geochemical methods and some pitting, trenching, tunneling and drilling to further evaluate the discovered occurrences. (author)

  1. Fresnel diffraction correction by phase-considered iteration procedure in soft X-ray projection microscopy

    International Nuclear Information System (INIS)

    In soft X-ray projection microscopy, it is easy to alter the magnification by changing the distance between the pinhole and the specimen, while the image is blurred because the soft X-rays are diffracted through the propagation from specimen to CCD detector. We corrected the blurred image by the iteration procedure of Fresnel to inverse Fresnel transformation taking phase distribution of the specimen into account. The experiments were conducted at the BL-11A of the Photon Factory, KEK, Japan for the specimens such as glass-capillaries, latex-particles, dried mammalian cells and human chromosomes. Many of those blurred images were corrected adequately by the iteration procedure, though some images such as those which have high-contrast or are overlapped by small cells still remain to be improved.

  2. Improved gas installations and services. Phase 1: Analysis project. Part report

    International Nuclear Information System (INIS)

    As Danish gas companies receive a large number of complaints related to the installation and operation of gas installations it was suggested that a course for personnel should be established in order to raise the standard of services and installation requirements. The first phase of the described project was to evaluate the quality of the gas installers' services so as to determine which aspects of installation and services should be emphasized during such a course. Interviews were carried out and questionnaires (illustrated within the document) sent out to installaters etc. Recommendations include that the level of information given to customers should be raised, also in relation to maintenance, and that installation should be improved. Analyses of the degree of customers' satisfaction, of the nature of the quality of services etc. expected, subjects for further training in this area and details of the training system are dealt with

  3. Characterization of holographically generated beams via phase retrieval based on Wigner distribution projections.

    Science.gov (United States)

    Rodrigo, José A; Alieva, Tatiana; Cámara, Alejandro; Martínez-Matos, O; Cheben, Pavel; Calvo, María L

    2011-03-28

    In this work, we propose a robust and versatile approach for the characterization of the complex field amplitude of holographically generated coherent-scalar paraxial beams. For this purpose we apply an iterative algorithm that allows recovering the phase of the generated beam from the measurement of its Wigner distribution projections. Its performance is analyzed for beams of different symmetry: Laguerre-Gaussian, Hermite-Gaussian and spiral ones, which are obtained experimentally by a computer generated hologram (CGH) implemented on a programmable spatial light modulator (SLM). Using the same method we also study the quality of their holographic recording on a highly efficient photopolymerizable glass. The proposed approach is useful for the creation of adaptive CGH that takes into account the peculiarities of the SLM, as well as for the quality control of the holographic data storage. PMID:21451630

  4. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Ghana

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) Mission to Ghana. The IUREP Orientation Phase Mission to Ghana estimates that the Speculative Resources of that country fall within the range of 15 000 to 40 000 tonnes of uranium. The majority of this potential is expected to be located in the Proterozoic Panafrican Mobile Belt (up to 17 000 tonnes uranium) and the Paleozoic Obosum Beds of the Voltaian basin (up to 15 000 tonnes uranium), the remainder being associated with various other geological environments. The mission recommends that over a period of three (3) years approximately U.S. $5 million) would be spent on exploration in Ghana. A major part of this (U.S $2 million) would be spent on an airborne spectrometer survey over the Voltaian basin (Obosum beds), much of the remainder being spent on ground surveys, trenching and percussion drilling. (author)

  5. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Venezuela

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) mission to Venezuela. The IUREP Orientation Phase mission to Venezuela estimates that the Speculative Resources of that country fall within the range 2,000 to 42,000 tonnes uranium.- The majority of this potential is expected to be located in the Precambrian crystalline and sedimentary rocks of the Guayana Shield. Other potentially favorable geologic environments include Cretaceous phosphorite beds, continental sandstone and granitic rocks. The mission recommends that approximately US $18 million be spent on exploration in Venezuela over the next five years. The majority of this expenditure would be for surface surveys utilizing geologic studies, radiometric and geochemical surveys and some drilling for geologic information. Additional drilling would be required later to substantiate preliminary findings. (author)

  6. Online monitoring of gas-solid two-phase flow using projected CG method in ECT image reconstruction

    Institute of Scientific and Technical Information of China (English)

    Qi wang; Chengyi Yang; Huaxiang Wang; Ziqiang Cui; Zhentao Gao

    2013-01-01

    Electrical capacitance tomography (ECT) is a promising technique for multi-phase flow measurement due to its high speed,low cost and non-intrusive sensing.Image reconstruction for ECT is an inverse problem of finding the permittivity distribution of an object by measuring the electrical capacitances between sets of electrodes placed around its periphery.The conjugate gradient (CG) method is a popular image reconstruction method for ECT,in spite of its low convergence rate.In this paper,an advanced version of the CG method,the projected CG method,is used for image reconstruction of an ECT system.The solution space is projected into the Krylov subspace and the inverse problem is solved by the CG method in a low-dimensional specific subspace.Both static and dynamic experiments were carried out for gas-solid two-phase flows.The flow regimes are identified using the reconstructed images obtained with the projected CG method.The results obtained indicate that the projected CG method improves the quality of reconstructed images and dramatically reduces computation time,as compared to the traditional sensitivity,Landweber,and CG methods.Furthermore,the projected CG method was also used to estimate the important parameters of the pneumatic conveying process,such as the volume concentration,flow velocity and mass flow rate of the solid phase.Therefore,the projected CG method is considered suitable for online gas-solid two-phase flow measurement.

  7. Speckle suppression in pattern projection profilometry with a thin sinusoidal phase grating by polychromatic illumination

    Science.gov (United States)

    Berberova, Nataliya; Stoykova, Elena; Park, Joo Sup; Kang, Hoonjong; Sainov, Ventseslav

    2013-03-01

    Pattern projection profilometry is a powerful tool to reconstruct three-dimensional (3D) surface of diffuse objects. A variety of pattern projection methods for 3D capture of objects is based on the generation of sinusoidal fringes. A sinusoidal phase grating under divergent coherent illumination with a point source produces high visibility and high spectral purity sinusoidal fringes in a large longitudinal region. In the present work we study the speckle suppression in the fringes by using a polychromatic light source. Such an approach makes use of the fact that the lateral fringe spacing does not depend on the wavelength of the illuminating light. The wavelength has an impact on the locations and the number of the Talbot planes, where self-imaging of the grating occurs, and on variation of the contrast and the frequency content of fringes along the distance from the grating. We analyze the multi-wavelength illumination of the grating by solving the Fresnel diffraction integral for a point source illumination in paraxial approximation. We verified the obtained results by experiments with a thin holographic grating recorded on a silver-halide holographic plate under illumination with a laser diode operating in single mode and multimode regimes.

  8. The MYRRHA ADS Project in Belgium Enters the Front End Engineering Phase

    Science.gov (United States)

    De Bruyn, Didier; Abderrahim, Hamid Aït; Baeten, Peter; Leysen, Paul

    The MYRRHA project started in 1998 by SCK•CEN. MYRRHA is a MTR, based on the ADS concept, for material and fuel research, for studying the feasibility of transmutation of Minor Actinides and Long-Lived Fission Products arising from radioactive waste reprocessing and finally for demonstrating at a reasonable power scale the principle of the ADS. The MYRRHA design has progressed through various framework programmes of the European Commission in the context of Partitioning and Transmutation. The design has now entered into the Front End Engineering Phase (FEED) covering the period 2012-2015. The engineering company, which will handle this phase, has been selected and the works have begun in the late 2013. In the mean time we have made some refinements in both primary systems and plant layout, including reactor building design. In this paper, we present the most recent developments of the MYRRHA design in terms of reactor building and plant layout as existing today as well as a preliminary study concerning the spent fuel building of the facility. During the oral presentation we add some preliminary results of the interaction with the FEED contractor and the most recent version of the primary systems.

  9. Lunar-Mars Life Support Test Project. Phase 2; Human Factors and Crew Interactions

    Science.gov (United States)

    Ming, D. W.; Hurlbert, K. M.; Kirby, G.; Lewis, J. F.; ORear, P.

    1997-01-01

    Phase 2 of the Lunar-Mars Life Support Test Project was conducted in June and July of 1996 at the NASA Johnson Space Center. The primary objective of Phase 2 was to demonstrate and evaluate an integrated physicochemical air revitalization and regenerative water recovery system capable of sustaining a human crew of four for 30 days inside a closed chamber. The crew (3 males and 1 female) was continuously present inside a chamber throughout the 30-day test. The objective of this paper was to describe crew interactions and human factors for the test. Crew preparations for the test included training and familiarization of chamber systems and accommodations, and medical and psychological evaluations. During the test, crew members provided metabolic loads for the life support systems, performed maintenance on chamber systems, and evaluated human factors inside the chamber. Overall, the four crew members found the chamber to be comfortable for the 30-day test. The crew performed well together and this was attributed in part to team dynamics, skill mix (one commander, two system experts, and one logistics lead), and a complementary mix of personalities. Communication with and support by family, friends, and colleagues were identified as important contributors to the high morale of the crew during the test. Lessons learned and recommendations for future testing are presented by the crew in this paper.

  10. Use of projectional phase space data to infer a 4D particle distribution

    International Nuclear Information System (INIS)

    We consider beams which are described by a 4D transverse distribution f(x, y, x(prime), y(prime)), where x(prime) (triplebond) px/pz and z is the axial coordinate. A two-slit scanner is commonly employed to measure, over a sequence of shots, a 2D projection of such a beam's phase space, e.g., f(x, x(prime)). Another scanner might yield f(y, y(prime)) or, using crossed slits, f(x, y). A small set of such 2D scans does not uniquely specify f(x, y, x(prime), y(prime)). We have developed ''tomographic'' techniques to synthesize a ''reasonable'' set of particles in a 4D phase space having 2D densities consistent with the experimental data. These techniques are described in a separate document [A. Friedman, et. al., submitted to Phys. Rev. ST-AB, 2002]. Here we briefly summarize one method and describe progress in validating it, using simulations of the High Current Experiment at Lawrence Berkeley National Laboratory

  11. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Morocco

    International Nuclear Information System (INIS)

    A report has recently been published on the findings of the mission to Morocco under the International Uranium Resources Evaluation Project (IUREP) Orientation Phase. The IUREP Orientation Phase Mission estimates that the speculative resources of Morocco range from 70 000 to 180 000 tonnes of uranium, half of which could be expected to occur in the Northern Provinces, which are relatively well explored, and the other half in the little explored Southern Provinces. In the north, speculative resources are fairly evenly distributed among the various types of deposit, in particular vein deposits (intragranitic and contact) linked with Hercynian and Precambrian blocks, the sandstone type deposits linked with Mesozoic strata and the volcanogenic deposits, especially of Precambrian age. The potential for large high-grade deposits, especially for those linked with unconformities and linear albitites, has been little investigated in Morocco and is chiefly thought to lie in the Precambrian in the Anti-Atlas and Southern Provinces. Here, the presence of acid volcanic rock reinforces the uranium potential, and there is also some potential for calcrete-related deposits. Phosphate-related uranium, to be recovered shortly, constitutes by far the largest reserves in Morocco, estimated at about 7 million tonnes of recoverable uranium. Recommendations have been made for further study of known occurrences and identification of new ones, such as unconformity and albitite-related deposits. (author)

  12. Recovery Efficiency Test Project Phase 2 activity report, Volume 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Salamy, S.P.; Locke, C.D.

    1989-02-01

    The purpose of Phase II operations of the Recovery Efficiency Test Project is to enhance the natural production of the well and evaluate the relative improvement as a function of the type of stimulation conducted. Another purpose is to compare the stimulated production performance of the horizontal well with vertical wells in the field. The objectives considered for Phase II operations and plans were: (1) Develop a rationale for a systematic approach to designing stimulations for the well. (2) Conduct a series of stimulations designed to optimize the fluids, injection rates, proppant volumes and general approach to stimulating a horizontal well with similar geologic conditions. (3) Develop and test a method or methods for determining the geometry of stimulation-induced fractures. (4) Conduct tests and analyze the results to determine the efficiency of stimulation operations. The technical approach pursued in developing plans to accomplish three objectives was to: (1) Review the data needs for all objectives and obtain that data first. (2) Identify the operating geologic, geomechanical, and reservoir parameters that need additional clarification or definition. (3) Investigate existing models which could be used to plan or evaluate stimulation on the well and the reservoir. (4) Plan for analysis and verification of models and approaches.

  13. Purdue University National Biomedical Tracer Facility: Project definition phase. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Green, M.A.

    1995-02-15

    The proposed National Biomedical Tracer Facility (NBTF) will house a high-current accelerator dedicated to production of short-lived radionuclides for biomedical and scientific research. The NBTF will play a vital role in repairing and maintaining the United States` research infrastructure for generation of essential accelerator-based radioisotopes. If properly designed and managed, the NBTF should also achieve international recognition as a Center-of-Excellence for research on radioisotope production methods and for associated education and training. The current report documents the results of a DOE-funded NBTF Project Definition Phase study carried out to better define the technical feasibility and projected costs of establishing and operating the NBTF. This report provides an overview of recommended Facility Design and Specifications, including Accelerator Design, Building Design, and the associated Construction Cost Estimates and Schedule. It is recommended that the NBTF be established as an integrated, comprehensive facility for meeting the diverse production, research, and educational missions set forth in previous documents. Based on an analysis of the projected production demands that will be placed on the NBTF, it appears that a 70 MeV, 1 mA, negative ion cyclotron will offer a good balance between production capabilities and the costs of accelerator purchase and operation. A preliminary architectural plan is presented for a facility designed specifically to fulfill the functions of the NBTF in a cost-effective manner. This report also presents a detailed analysis of the Required Federal State, and Local Permits that may be needed to establish the NBTF, along with schedules and cost estimates for obtaining these permits. The Handling, Storage, and Disposal of Radioactive Waste will pose some significant challenges in the operation of the NBTF, but at this stage of planning the associated problems do not appear to be prohibitive.

  14. Project SAFE. Update of the SFR-1 safety assessment. Phase 1

    International Nuclear Information System (INIS)

    SFR-1 is a facility for disposal of low-level radioactive operational waste from the nuclear power plants in Sweden. Low-level radioactive waste from industry, medicine, and research is also disposed in SFR-1. The facility is situated in bedrock beneath the Baltic Sea, 1 km off the coast near the Forsmark nuclear power plant. SFR-1 was built between the years 1983 and 1988. An assessment of the long-term performance of the facility was included in the vast documentation that was a part of the application for an operational license. The assessment was presented in the form of a final safety report. In the operational licence for SFR-1 it is stated that renewed safety assessments should be carried out at least each ten years. In order to meet this demand SKB has launched a special project, SAFE (Safety Assessment of Final Disposal of Operational Radioactive Waste). The aim of the project is to update the safety analysis and to prepare a safety report that will be presented to the Swedish authorities not later than year 2000. Project SAFE is divided into three phases. The first phase is a prestudy, and the results of the prestudy are given in this report. The aim of the prestudy is to identify issues where additional studies would improve the basis for the updated safety analysis as well as to suggest how these studies should be carried out. The work has been divided into six different topics, namely the inventory, the near field, the far field, the biosphere, radionuclide transport calculations and scenarios. For each topic the former safety reports and regulatory reviews are scrutinised and needs for additional work is identified. The evaluations are given in appendices covering the respective topics. The main report is a summary of the appendices with a more stringent description of the repository system and the processes that are of interest and therefore should be addressed in an updated safety assessment. However, it should be pointed out that one of the

  15. Overview of the Coupled Model Intercomparison Project Phase 6 (CMIP6) experimental design and organization

    Science.gov (United States)

    Eyring, Veronika; Bony, Sandrine; Meehl, Gerald A.; Senior, Catherine A.; Stevens, Bjorn; Stouffer, Ronald J.; Taylor, Karl E.

    2016-05-01

    By coordinating the design and distribution of global climate model simulations of the past, current, and future climate, the Coupled Model Intercomparison Project (CMIP) has become one of the foundational elements of climate science. However, the need to address an ever-expanding range of scientific questions arising from more and more research communities has made it necessary to revise the organization of CMIP. After a long and wide community consultation, a new and more federated structure has been put in place. It consists of three major elements: (1) a handful of common experiments, the DECK (Diagnostic, Evaluation and Characterization of Klima) and CMIP historical simulations (1850-near present) that will maintain continuity and help document basic characteristics of models across different phases of CMIP; (2) common standards, coordination, infrastructure, and documentation that will facilitate the distribution of model outputs and the characterization of the model ensemble; and (3) an ensemble of CMIP-Endorsed Model Intercomparison Projects (MIPs) that will be specific to a particular phase of CMIP (now CMIP6) and that will build on the DECK and CMIP historical simulations to address a large range of specific questions and fill the scientific gaps of the previous CMIP phases. The DECK and CMIP historical simulations, together with the use of CMIP data standards, will be the entry cards for models participating in CMIP. Participation in CMIP6-Endorsed MIPs by individual modelling groups will be at their own discretion and will depend on their scientific interests and priorities. With the Grand Science Challenges of the World Climate Research Programme (WCRP) as its scientific backdrop, CMIP6 will address three broad questions: - How does the Earth system respond to forcing? - What are the origins and consequences of systematic model biases? - How can we assess future climate changes given internal climate variability, predictability, and uncertainties in

  16. Overview of the Coupled Model Intercomparison Project Phase 6 (CMIP6) experimental design and organisation

    Science.gov (United States)

    Eyring, V.; Bony, S.; Meehl, G. A.; Senior, C.; Stevens, B.; Stouffer, R. J.; Taylor, K. E.

    2015-12-01

    By coordinating the design and distribution of global climate model simulations of the past, current and future climate, the Coupled Model Intercomparison Project (CMIP) has become one of the foundational elements of climate science. However, the need to address an ever-expanding range of scientific questions arising from more and more research communities has made it necessary to revise the organization of CMIP. After a long and wide community consultation, a new and more federated structure has been put in place. It consists of three major elements: (1) a handful of common experiments, the DECK (Diagnostic, Evaluation and Characterization of Klima experiments) and the CMIP Historical Simulation (1850-near-present) that will maintain continuity and help document basic characteristics of models across different phases of CMIP, (2) common standards, coordination, infrastructure and documentation that will facilitate the distribution of model outputs and the characterization of the model ensemble, and (3) an ensemble of CMIP-Endorsed Model Intercomparison Projects (MIPs) that will be specific to a particular phase of CMIP (now CMIP6) and that will build on the DECK and the CMIP Historical Simulation to address a large range of specific questions and fill the scientific gaps of the previous CMIP phases. The DECK and CMIP Historical Simulation, together with the use of CMIP data standards, will be the entry cards for models participating in CMIP. The participation in the CMIP6-Endorsed MIPs will be at the discretion of the modelling groups, and will depend on scientific interests and priorities. With the Grand Science Challenges of the World Climate Research Programme (WCRP) as its scientific backdrop, CMIP6 will address three broad questions: (i) how does the Earth system respond to forcing?, (ii) what are the origins and consequences of systematic model biases?, and (iii) how can we assess future climate changes given climate variability, predictability and

  17. W.A. Parish Post-Combustion CO{sub 2} Capture and Sequestration Project Phase 1 Definition

    Energy Technology Data Exchange (ETDEWEB)

    Armpriester, Anthony; Smith, Roger; Scheriffius, Jeff; Smyth, Rebecca; Istre, Michael

    2014-02-01

    For a secure and sustainable energy future, the United States (U.S.) must reduce its dependence on imported oil and reduce its emissions of carbon dioxide (CO{sub 2}) and other greenhouse gases (GHGs). To meet these strategic challenges, the U.S. wiU have to create fundamentally new technologies with performance levels far beyond what is now possible. Developing advanced post-combustion clean coal technologies for capturing CO{sub 2} from existing coal-fired power plants can play a major role in the country's transition to a sustainable energy future, especially when coupled with CO{sub 2}-enhanced oil recovery (CO{sub 2}-EOR). Pursuant to these goals, NRG Energy, Inc. (NRG) submitted an application and entered into a cost-shared collaboration with the U.S. Department of Energy (DOE) under Round 3 of the Clean Coal Power Initiative (CCPI) to advance low-emission coal technologies. The objective of the NRG W A Parish Post-Combustion CO{sub 2} Capture and Sequestration Demonstration Project is to establish the technical feasibility and economic viability of post-combustion CO{sub 2} capture using flue gas from an existing pulverized coal-fired boiler integrated with geologic sequestration via an enhanced oil recovery (EOR) process. To achieve these objectives, the project will be executed in three phases. Each phase represents a distinct aspect of the project execution. The project phases are: • Phase I. Project Definition/Front-End Engineering Design (FEED) • Phase ll. Detailed Engineering, Procurement & Construction • Phase III. Demonstration and Monitoring The purpose of Phase I is to develop the project in sufficient detail to facilitate the decision-making process in progressing to the next stage of project delivery. Phase n. This report provides a complete summary of the FEED study effort, including pertinent project background information, the scope of facilities covered, decisions, challenges, and considerations made regarding configuration and

  18. Final report for the ASC gas-powder two-phase flow modeling project AD2006-09.

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Gregory Herbert; Winters, William S.

    2007-01-01

    This report documents activities performed in FY2006 under the ''Gas-Powder Two-Phase Flow Modeling Project'', ASC project AD2006-09. Sandia has a need to understand phenomena related to the transport of powders in systems. This report documents a modeling strategy inspired by powder transport experiments conducted at Sandia in 2002. A baseline gas-powder two-phase flow model, developed under a companion PEM project and implemented into the Sierra code FUEGO, is presented and discussed here. This report also documents a number of computational tests that were conducted to evaluate the accuracy and robustness of the new model. Although considerable progress was made in implementing the complex two-phase flow model, this project has identified two important areas that need further attention. These include the need to compute robust compressible flow solutions for Mach numbers exceeding 0.35 and the need to improve conservation of mass for the powder phase. Recommendations for future work in the area of gas-powder two-phase flow are provided.

  19. Improved fiber-optic link for the phase reference distribution system for the TESLA technology based projects

    Science.gov (United States)

    Czuba, Krzysztof; Felber, Matthias

    2005-09-01

    The UV Free-Electron Laser (UVFEL) [1], The X-Ray Free-Electron Laser (XFEL) [2] and The International Linear Accelerator (ILC) [9] projects will require phase synchronization of various RF frequency subsystems on kilometer distances with accuracy better than 1ps. To fulfill these requirements, a phase reference distribution system concept was proposed and a prototype was developed for tests in the TESLA Test Facility 2 (TTF2). An important part of the phase reference system is the fiber-optic phase stable, long distance link described in this paper. An interferometrical scheme with feedback on phase, suppressing long term phase drifts induced by temperature changes was developed and tested in laboratory and under accelerator conditions. A motorized optical delay line was used in the system to compensate for phase errors. Described are error considerations and most important project issues like the hardware development and the real time phase controller software. The presented measurement results satisfy the design requirements. Experience gained during the experiments yielded proposals for system improvements.

  20. Simulation of the multiple-fracture model. Phase 1, benchmark test 2 of the DECOVALEX project

    International Nuclear Information System (INIS)

    DECOVALEX is an international co-operative project for the development of coupled models and their validation against experiments in nuclear waste isolation. The emphasis of this project is on the coupled thermo-hydro-mechanical effects in jointed hard rock. In the first phase of DECOVALEX, two benchmark tests and one test case have been selected for modelling. This report describes the results of the second benchmark test, the Multiple-Fracture Model, as obtained by the AECL Research team. This problem relates to groundwater flow and coupled thermo-hydro-mechanical deformation in a simple system comprising several blocks of porous medium and several intersecting fractures. The simulation domain is defined to be a rectangular box that is made up of an assemblage of nine blocks separated by two sets of discontinuities (planar fractures). The rock mass is subjected to in situ stress and thermal loading as well as a hydraulic gradient. Both no-flow and adiabatic heat flux acting along a section of one of the lateral boundaries will induce expansion of the rock and cause shearing in the model. The MOTIF finite-element code, developed at AECL, has been employed to simulate this problem. The simulation results show that thermal expansion of the solid blocks reduced the aperture and, consequently, the permeability of the fractures. As a result, the fluid velocity along the horizontal fractures decreased with time, except in the vicinity close to the heat source, where the velocity initially increased and then decreased as a result of the decrease in permeability. (author). 9 refs., 7 tabs., 23 figs

  1. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Bolivia. Draft

    International Nuclear Information System (INIS)

    The uranium exploration done so far in Bolivia has been carried out by COBOEN, partly with IAEA support, and AGIP S.p.A. of Italy, which between 1974 and 1978 explored four areas in various parts of Bolivia under a production sharing contract with COBOEN. The basic objective of the International Uranium Resources Evaluation Project (IUREP) is to 'review the present body of knowledge pertinent to the existence of uranium resources, to review and evaluate the potential for discovery of additional uranium resources, and to suggest new exploitation efforts which might be carried out in promising areas in collaboration with the country concerned'. Following the initial bibliographic study which formed Phase I of IUREP, it was envisaged that a further assessment in cooperation with, and within, the country concerned would provide a better delineation of areas of high potential and a more reliable estimate as to the degree of favourability for the discovery of additional uranium resources. It was planned that such work would be accomplished through field missions to the country concerned and that these field missions and the resulting report would be known as the Orientation Phase of IUREP. The purpose of the Orientation Phase mission to Bolivia was a) to develop a better understanding of the uranium potential of the country, b) to make an estimate of the Speculative Resources of the country, c) to delineate areas favourable for the discovery of these uranium resources, d) to make recommendations as appropriate on the best methods for evaluating the favourable areas, operating procedures and estimated possible costs, e) to develop the logistical data required to carry out any possible further work, and f) to compile a report which would be immediately available to the Bolivian authorities. The mission reports contains information about a general introduction, non-uranium exploration and mining in Bolivia, manpower in exploration, geological review of Bolivia, past uranium

  2. Assay method and compositions

    International Nuclear Information System (INIS)

    Methods are described for measuring catecholamine levels in human and animal body fluids and tissues using the catechol-O-methyl-transferase (COMT) radioassay. The assay involves incubating the biological sample with COMT and the tritiated methyl donor, S-adenosyl-L-methionine(3H)-methyl. The O-methylated (3H) epinephrine and/or norepinephrine are extracted and oxidised to vanillin-3H which in turn is extracted and its radioactivity counted. When analysing dopamine levels the assay is extended by vanillin-3H and raising the pH of the aqueous periodate phase from which O-methylated (3H) dopamine is extracted and counted. The assay may be modified depending on whether measurements of undifferentiated total endogenous catecholamine levels or differential analyses of the catecholamine levels are being performed. The sensitivity of the assay can be as low as 5 picograms for norepinephrine and epinephrine and 12 picograms for dopamine. The assemblance of the essential components of the assay into a kit for use in laboratories is also described. (U.K.)

  3. Research project MAW and HTR fuel element test storage in boreholes (MHV project). Emplacement and borehole sealing techniques (EBT part-project). Final report on project phase October 1, 1989 - December 31, 1992

    International Nuclear Information System (INIS)

    The paper documents the working results of the third project phase from 1.10.89 to 31.12.92. At the beginning, the atmosphere in the repository borehole during the operational and post-operational phase is described. The borehole atmosphere is decisively influenced by gas and humidity releases from the waste forms and the solid rock salt, by the propagation of gases in the unfilled part of the borehole and in the part backfilled with salt grit, and by the permiabilities of the borehole lock and the solid bedrock. Hydrogen gas may be oxidized by an addition agent. The reference concept of borehole storage is the embedding of the waste forms in salt grit. The salt grit backfill required therefore is characterized, and pressure distribution in the backfill during storing of the forms in the borehole is modelled. Finally the flame extinguishing effect of salt grit is described. Safety considerations and a draft concept of a borehole backfill container complete the work of this project phase. (orig./HP)

  4. A surface profile reconstruction system using sinusoidal phase-modulating interferometry and fiber-optic fringe projection

    Science.gov (United States)

    En, Bo; Fa-jie, Duan; Chang-rong, Lv; Fan, Feng; Xiao, Fu

    2014-06-01

    A fiber-optic sinusoidal phase modulating (SPM) interferometer for surface profile reconstruction is presented. Sinusoidal phase modulation is created by modulating the drive voltage of the piezoelectric transducer. The surface profile is constructed basing on fringe projection. Fringe patterns are vulnerable to external disturbances such as temperature fluctuation and mechanical vibration, which cause phase drift and decrease measuring accuracy. We build a closed-loop feedback phase compensation system, the bias value of external disturbances superimposed on fringe patterns can be reduced to about 50 mrad, and the phase stability for interference fringes is less than 5.76 mrad. By measuring the surface profile of a paper plate for two times, the repeatability is estimated to be about 11 nm, and is equivalent to be about λ/69. For a plane with 100 × 100 points, a single measurement takes less than 140 ms, and the feasibility for real-time profile measurement with high accuracy has been verified.

  5. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Zambia

    International Nuclear Information System (INIS)

    A report has recently been published which describes the findings of the International Uranium Resources Evaluation Project (IUREP) mission to Zambia. The IUREP Orientation Phase mission to Zambia estimates that the Speculative Resources of that country fall within the range of 33 000 and 100 000 tonnes uranium. The majority of these resources are believed to exist in the Karoo sediments. Other potentially favourable geological environments are the Precambrian Katanga sediments, as well as intrusive rocks of different chemical compositions and surficial duricrusts. Previous unofficial estimates of Zambia's Reasonably Assured Resources (RAR) and Estimated Additional Resources (EAR) are considered to be still valid: the total RAR amount to 6 000 tonnes uranium, located in Karoo (4 000 tonnes) and Katanga (2 000 tonnes) sediments, while the EAR are believed to total 4 000 tonnes being found only in Karoo sediments. The mission recommends that approximately US$ 40 million be spent on uranium exploration in Zambia over 10 years. The largest part of this expenditure would be for drilling, while the remainder should be spent on airborne and ground surveys, as well as on interpretative work on previous airborne data, Landsat imageries, etc. (author)

  6. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Somalia

    International Nuclear Information System (INIS)

    A full report has been compiled describing the findings of the International Uranium Resources Evaluation Project (IUREP) Orientation Phase Mission to Somalia. The Mission suggests that in addition to the reasonably assured resources (RAR) of 5 000 t uranium and estimated additional resources (EAR) of 11 000 t uranium in calcrete deposits, the speculative resources (SR) could be within the wide range of 0 - 150 000 t uranium. The majority of these speculative resources are related to sandstone and calcrete deposits. The potential for magmatic hydrothermal deposits is relatively small. The Mission recommends an exploration programme of about US$ 22 000 000 to test the uranium potential of the country which is thought to be excellent. The Mission also suggests a reorganization of the Somalia Geological Survey in order to improve its efficiency. Recommended methods include geological mapping, Landsat imagery interpretation, airborne and ground scintillometer surveys, and geochemistry. Follow-up radiometric surveys, exploration geophysics, mineralogical studies, trenching and drilling are proposed in favourable areas. (author)

  7. Evaluation of the GEM-AQ model in the context of the AQMEII Phase 1 project

    Science.gov (United States)

    Struzewska, J.; Zdunek, M.; Kaminski, J. W.; Łobocki, L.; Porebska, M.; Jefimow, M.; Gawuc, L.

    2015-04-01

    In the scope of the AQMEII Phase 1 project the GEM-AQ model was run over Europe for the year 2006. The modelling domain was defined using a global variable resolution grid with a rotated equator and uniform resolution of 0.2° × 0.2° over the European continent. Spatial distribution and temporal variability of the GEM-AQ model results were analysed for surface ozone and PM10 concentrations. Model results were compared with measurements available in the ENSEMBLE database. Statistical measures were used to evaluate performance of the GEM-AQ model. The mean bias error, the mean absolute gross error and the Pearson correlation coefficient were calculated for the maximum 8 h running average ozone concentrations and daily mean PM10 concentrations. The GEM-AQ model performance was characterized for station types, European climatic regions and seasons. The best performance for ozone was obtained at suburban stations, and the worst performance was obtained for rural stations where the model tends to underestimate. The best results for PM10 were calculated for urban stations, while over most of Europe concentrations at rural sites were too high. Discrepancies between modelled and observed concentrations were discussed in the context of emission data uncertainty as well as the impact of large-scale dynamics and circulation of air masses. Presented analyses suggest that interpretation of modelling results is enhanced when regional climate characteristics are taken into consideration.

  8. Evaluation of the GEM-AQ model in the context of the AQMEII Phase 1 project

    Directory of Open Access Journals (Sweden)

    J. Struzewska

    2015-04-01

    Full Text Available In the scope of the AQMEII Phase 1 project the GEM-AQ model was run over Europe for the year 2006. The modelling domain was defined using a global variable resolution grid with a rotated equator and uniform resolution of 0.2° × 0.2° over the European continent. Spatial distribution and temporal variability of the GEM-AQ model results were analysed for surface ozone and PM10 concentrations. Model results were compared with measurements available in the ENSEMBLE database. Statistical measures were used to evaluate performance of the GEM-AQ model. The mean bias error, the mean absolute gross error and the Pearson correlation coefficient were calculated for the maximum 8 h running average ozone concentrations and daily mean PM10 concentrations. The GEM-AQ model performance was characterized for station types, European climatic regions and seasons. The best performance for ozone was obtained at suburban stations, and the worst performance was obtained for rural stations where the model tends to underestimate. The best results for PM10 were calculated for urban stations, while over most of Europe concentrations at rural sites were too high. Discrepancies between modelled and observed concentrations were discussed in the context of emission data uncertainty as well as the impact of large-scale dynamics and circulation of air masses. Presented analyses suggest that interpretation of modelling results is enhanced when regional climate characteristics are taken into consideration.

  9. Evaluation of the GEM-AQ model in the context of the AQMEII Phase 1 project

    Directory of Open Access Journals (Sweden)

    J. Struzewska

    2015-01-01

    Full Text Available In the scope of the AQMEII Phase 1 project the GEM-AQ model was run over Europe for the year 2006. The modelling domain was defined using a global variable resolution grid with a rotated equator and uniform resolution of 0.2° × 0.2° over the European continent. Spatial distribution and temporal variability of the GEM-AQ model results were analysed for surface ozone and PM10 concentrations. Model results were compared with measurements available in the ENSEMBLE database. Statistical measures were used to evaluate performance of the GEM-AQ model. The mean bias error, the mean absolute gross error and the Pearson correlation coefficient were calculated for the maximum 8 h running average ozone concentrations and daily mean PM10 concentrations. The GEM-AQ model performance was characterised for station types, European climatic regions, and seasons. The best performance for ozone was obtained at suburban stations and the worst performance was obtained for rural stations where the model tends to underestimate. The best results for PM10 were calculated for urban stations, while over most of Europe concentrations at rural sites were too high. Discrepancies between modelled and observed concentrations were discussed in the context of emission data uncertainty as well as the impact of large scale dynamics and circulation of air masses. Presented analyses suggest that interpretation of modelling results is enhanced when regional climate characteristics are ta ken into consideration.

  10. Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project pilot phase.

    Science.gov (United States)

    Berhane, Beniam T; Zong, Chenggong; Liem, David A; Huang, Aaron; Le, Steven; Edmondson, Ricky D; Jones, Richard C; Qiao, Xin; Whitelegge, Julian P; Ping, Peipei; Vondriska, Thomas M

    2005-08-01

    Proteomic profiling of accessible bodily fluids, such as plasma, has the potential to accelerate biomarker/biosignature development for human diseases. The HUPO Plasma Proteome Project pilot phase examined human plasma with distinct proteomic approaches across multiple laboratories worldwide. Through this effort, we confidently identified 3020 proteins, each requiring a minimum of two high-scoring MS/MS spectra. A critical step subsequent to protein identification is functional annotation, in particular with regard to organ systems and disease. Performing exhaustive literature searches, we have manually annotated a subset of these 3020 proteins that have cardiovascular-related functions on the basis of an existing body of published information. These cardiovascular-related proteins can be organized into eight groups: markers of inflammation and/or cardiovascular disease, vascular and coagulation, signaling, growth and differentiation, cytoskeletal, transcription factors, channels/receptors and heart failure and remodeling. In addition, analysis of the peptide per protein ratio for MS/MS identification reveals group-specific trends. These findings serve as a resource to interrogate the functions of plasma proteins, and moreover, the list of cardiovascular-related proteins in plasma constitutes a baseline proteomic blueprint for the future development of biosignatures for diseases such as myocardial ischemia and atherosclerosis. PMID:16052623

  11. STTR Phase 1 Final Technical Report for Project Entitled "Developing a Mobile Torrefaction Machine"

    Energy Technology Data Exchange (ETDEWEB)

    James, Joseph J. [President, ATP

    2014-03-11

    The goal of this project, sponsored by Agri-Tech Producers, LLC (ATP), the small business grantee, was to determine if the torrefaction technology, developed by North Carolina State University (NCSU), which ATP has licensed, could be feasibly deployed in a mobile unit. The study adds to the area investigated, by having ATP’s STTR Phase I team give thoughtful consideration to how to use NCSU’s technology in a mobile unit. The findings by ATP’s team were that NCSU’s technology would best perform in units 30’ by 80’ (See Spec Sheet for the Torre-Tech 5.0 Unit in the Appendix) and the technical effectiveness and economic feasibility investigation suggested that such units were not easily, efficiently or safely utilized in a forest or farm setting. (Note rendering of possible mobile system in the Appendix) Therefore, the findings by ATP’s team were that NCSU’s technology could not feasibly be deployed as a mobile unit.

  12. Radioreceptor assays

    International Nuclear Information System (INIS)

    Radioreceptor assay (RRA) is an analytical method using the specific interaction of some pharmaceuticals and endogenic substances (ligands) with specific receptors present in certin tissues of living organisms. RRA uses the principle of isotope dilution. The method is described in detail of the preparation of receptors, samples and radioligands, conditions of incubation, the separation of free and bound radioligand, and the mathematical evaluation of RRA. The sensitivity of RRA is measured in units to tens of pg. The specificity of RRA relates to a group of substances with similar pharmacological effect. RRA may be used for identifying neuroleptics, antidepressants, anxiolytics, ergot alkaloids, beta blockers, anticholinergic drugs, certain hormones and neuropeptides. (M.D.)

  13. Justification of the Dual-Phase Project-Based Pedagogical Approach in a Primary School Technology Unit

    Science.gov (United States)

    Drain, Michael

    2010-01-01

    This research paper describes the use of the Cognitive Apprenticeship (CA) framework to analyse the practices of teacher and students observed during a technology unit. Twenty three children aged 9-10 years were involved in the research and they were taught in a standard classroom. The analysis provides evidence that a two-phase project-based…

  14. Sustainable development in city districts: BaLaLuZ project - Gundeldinger Feld - Phase 1; Schlussbericht Quartier Gundeldingerfeld Basel - Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Binz, A.; Voyame, J.-P.

    2004-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) is one of a series of reports concerning municipal development in various cities in Switzerland. The four city districts involved include Basel (Gundeldinger Feld), Lausanne (Bellevaux), Lucerne (Basel-/Bernstrasse) and Zurich (Werdwies). This final report summarises the results of the first phase of the project in Gundeldinger Feld, Basel. In an analysis of the initial situation in the Gundeldinger Feld, ecological and economical aspects are examined as are questions concerning mobility and urban planning. The various players involved are introduced and their expectations reviewed; work done and the involvement of the local inhabitants in the project are looked at. Measures to be taken to realise the visions proposed are discussed and suggestions for projects are made.

  15. Angiogenesis Assays.

    Science.gov (United States)

    Nambiar, Dhanya K; Kujur, Praveen K; Singh, Rana P

    2016-01-01

    Neoangiogenesis constitutes one of the first steps of tumor progression beyond a critical size of tumor growth, which supplies a dormant mass of cancerous cells with the required nutrient supply and gaseous exchange through blood vessels essentially needed for their sustained and aggressive growth. In order to understand any biological process, it becomes imperative that we use models, which could mimic the actual biological system as closely as possible. Hence, finding the most appropriate model is always a vital part of any experimental design. Angiogenesis research has also been much affected due to lack of simple, reliable, and relevant models which could be easily quantitated. The angiogenesis models have been used extensively for studying the action of various molecules for agonist or antagonistic behaviour and associated mechanisms. Here, we have described two protocols or models which have been popularly utilized for studying angiogenic parameters. Rat aortic ring assay tends to bridge the gap between in vitro and in vivo models. The chorioallantoic membrane (CAM) assay is one of the most utilized in vivo model system for angiogenesis-related studies. The CAM is highly vascularized tissue of the avian embryo and serves as a good model to study the effects of various test compounds on neoangiogenesis. PMID:26608294

  16. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Republic of Burundi. Draft

    International Nuclear Information System (INIS)

    The basic objective of the International Uranium Resources Evaluation project lUREP is to 'Review the present body of knowledge pertinent to the existence of uranium resources, to review and evaluate the potential for the discovery of additional uranium resources and to suggest new exploration efforts which might be carried out in promising areas in collaboration with the countries concerned'. Therefore, the scope of the IUREP orientation phase Mission to Burundi was to review all data on past exploration in Burundi, to develop a better understanding of the uranium potential of the country, to make an estimate of the speculative resources of the country, to make recommendation as appropriate on the best methods or techniques for evaluating the resources in the favourable areas and for estimating possible costs as well, to compile a report which could be immediately available to the Burundian authorities. This mission gives a general introduction, a geological review of Burundi, information on non-uranium mining in Burundi, the history of uranium exploration, occurrences of uranium IUREP mission field reconnaissance, favourable areas for speculative potential, the uranium resources position and recommendations for future exploration. Conclusions are the following. The IUREP Orientation -phase mission to Burundi believes that the Speculative Resources of that country fall between 300 and 4100 tons uranium oxide but a less speculative appraisal is more likely between 0 and 1000 tons. There has been no uranium production and no official estimates of Uranium Resources in Burundi. Past exploration mainly dating from 1969 onwards and led the UNDP Mineral project has indicated a limited number of uranium occurrences and anomalies. The speculative uranium resources are thought to be possibly associated with potential unconformity related vein-like deposits of the Lower Burundian. Other speculative uranium resources could be associated with granitic or peribatholitic

  17. Use of Social Network Analysis in Early Phases of ICT Projects

    OpenAIRE

    Libor Mesicek; Jiri Svoboda

    2012-01-01

    According to results of our surveys in 2011 the ICT project managers operating in the Czech Republic would like to have wider possibility of influencing the selection of team members in their projects.The article focuses on the psychological and the sociological aspects of the ICT project teams’ structure, analyzing the existing social networks within a company as well as the concept of the team roles when setting up the project team by mapping the existing relationships among the team member...

  18. Waveguide Phase Modulator for Integrated Planar Lightwave Circuits in KTP Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort proposes the development of a potassium titanyl phosphate (KTP) waveguide phase modulator for future integration into a Planar Lightwave...

  19. High Performance Ka-band Phase Shifters for Space Telecommunications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose a novel MEMS-based digital phase shifter targeted for Ka-band operation, but scalable down to X-band and up to W-band. This novel phase shifter will...

  20. Design and Development of a compact and ruggest phase and flouresence microscope for space utilization Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR Phase 1 we propose to develop a novel microscope by integrating Fourier phase contrast microscopy (FPCM) and epi-fluorescence microscopy. In FPCM, the...

  1. Presentation of main results of Phase I of the SMPR project initiation study

    International Nuclear Information System (INIS)

    As a result of a first Technical Committee Meeting held in Vienna in August 1983 the IAEA launched a new SMPR Project Initiation Study with the objective of surveying the available designs, examining the major factors influencing the decision-making processes in developing countries and thereby also arriving at an estimate of the potential market. The Nuclear Energy Agency of OECD offered its assistance in making a study of the potential market in industrialized countries. Two questionnaires were used to obtain information from potential suppliers and buyers. Suppliers responded with an overwhelming 23 design concepts which could be offered for export but with varying levels of readiness and provenness. From potential buyers 17 responses were received, 16 of which were from the developing countries. The analysis of the responses which was done by the Agency with the help of experts from Member States gave the basis for a draft report including the OECD/NEA part. This draft was discussed during a second Technical Committee Meeting held in Vienna in March 1985. The meeting was characterized by a strong supplier interest but also by hesitation of potential buyers to make any kind of commitments relating to the market introduction of SMPRs. All new information has been incorporated into the report together with a number of expressed comments, especially related to the presentation of the economics of SMPRs, the necessity of a reference plant, provenness of major components and systems etc. The results of the study are presented here with direct reference to the SMPR supply situation and the potential market for SMPRs in terms of the decision-making factors: the financial factors, the economical factors, and the technological factors were identified as the most important ones. The economic competitiveness is not the only decision-making factor and consequently it was decided to end the general study called Phase I by the publication of a report. Specific case studies

  2. New shipyard layout design for the preliminary phase & case study for the green field project

    Science.gov (United States)

    Song, Young Joo; Woo, Jong Hun

    2013-03-01

    For several decades, Asian nations such as Korea, Japan and China have been leading the shipbuilding industry since the decline in Europe and America. However, several developing countries such as India, Brazil, etc. are going to make an entrance into the shipbuilding industry. These developing countries are finding technical partners or information providers because they are in situation of little experiences and technologies. Now, the shipbuilding engineering companies of shipbuilding advanced countries are getting a chance of engineering business against those developing countries. The starting point of this business model is green field project for the construction of new shipyard. This business model is started with a design of the shipyard layout. For the conducting of the shipyard layout design, four kinds of engineering parts are required. Those are civil engineering, building engineering, utility engineering and production layout engineering. Among these parts, production layout engineering is most important because its result is the foundation of the other engineering parts and it determines the shipyard capacity during the shipyard operation lifecycle. Previous researches about the shipyard layout design are out of the range from the business requirements because most research cases are in the tower of ivory, which means that there are little consideration of real ship and shipbuilding operation. In this paper, a shipyard layout design for preliminary phase is conducted for the target of newly planned shipyard at Venezuela of South America with an integrated method that is capable of dealing with actual master data from the shipyard. The layout design method of this paper is differentiated from the previous researches in that the actual product data from the target ship and the actual shipbuilding operation data are used for the required area estimation.

  3. Minnesota Project: district heating and cooling through power plant retrofit and distribution network. Final report. Phase 1. [Minnesota Project

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-01-01

    Appendices are presented for the Minnesota Project: District Heating and Cooling Through Power Plant Retrofit and Distribution Network. These are: SYNTHA results (SYNTHA II is a proprietary program of the SYNTHA Corporation); Market Survey Questionnaire: Environmental Review Procedures; Public Service Commission Regulation of District Heating; Energy Use Normalization Procedures; Power Plant Description; Letters of Commitment; Bond Opinion and Issuance; and Marvin Koeplin Letter, Chairman of Public Service Commission, Moorehead, Minnesota.

  4. Prototypical Rod Construction Demonstration Project. Phase 3, Final report: Volume 1, Cold checkout test report, Book 3

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The objective of Phase 3 of the Prototypical Rod consolidation Demonstration Project (PRCDP) was to procure, fabricate, assemble, and test the Prototypical Rod consolidation System as described in the NUS Phase 2 Final Design Report. This effort required providing the materials, components, and fabricated parts which makes up all of the system equipment. In addition, it included the assembly, installation, and setup of this equipment at the Cold Test Facility. During the Phase 3 effort the system was tested on a component, subsystem, and system level. This volume 1, discusses the PRCDP Phase 3 Test Program that was conducted by the HALLIBURTON NUS Environmental Corporation under contract AC07-86ID12651 with the United States Department of Energy. This document, Volume 1, Book 3 discusses the following topics: Downender Test Results and Analysis Report; NFBC Canister Upender Test Results and Analysis Report; Fuel Assembly Handling Fixture Test Results and Analysis Report; and Fuel Canister Upender Test Results and Analysis Report.

  5. Sustainable development in city districts: BaLaLuZ project - Bellevaux Phase 2; Quartiers durables BaLaLuZh. Rapport Lausanne-Bellevaux. Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, D.; Nicol, L. [Swiss Federal Institute of Technology (EPFL), Laboratoire d' energie solaire et de physique du batiment (LESO-PB), Lausanne (Switzerland); Pattaroni, L. [Swiss Federal Institute of Technology (EPFL), Laboratoire de sociologie urbaine (LASUR), Lausanne (Switzerland); Muehll, D. von der [Swiss Federal Institute of Technology (EPFL), Laboratoire Choros, Lausanne (Switzerland)

    2007-04-15

    This comprehensive final report for the Swiss Federal Office of Energy (SFOE) is one of a series of reports concerning municipal development in various cities in Switzerland. The four city districts involved include Basel (Gundeldinger Feld), Lausanne (Bellevaux), Lucerne (Basel-/Bernstrasse) and Zurich (Werdwies). This final report summarises the results of the second phase of the project in the Bellevaux district of Lausanne. The work done in this second phase is reviewed. The results of phase 1 were followed up in that it was decided to facilitate the renovation of specific buildings where possible. A further aim was to evaluate the extent to which cycling is used as a means of transport as well as to identify possible barriers and solutions to the more widespread use of cycling as a means of transportation. The report describes the work necessary and strategies for specific buildings, including participatory procedures. As far as cycling is concerned, the results of questionnaires are examined and discussed. Communication and animation projects are also looked at.

  6. A multisubstrate assay for lipases/esterases: assessing acyl chain length selectivity by reverse-phase high-performance liquid chromatography.

    Science.gov (United States)

    Divakar, K; Gautam, Pennathur

    2014-03-01

    Lipases and esterases are hydrolytic enzymes and are known to hydrolyze esters with unique substrate specificity and acyl chain length selectivity. We have developed a simple competitive multiple substrate assay for determination of acyl chain length selectivity of lipases/esterases using RP-HPLC with UV detection. A method for separation and quantification of 4-nitrophenyl fatty acid esters (C4-C18) was developed and validated. The chain length selectivity of five lipases and two esterases was determined in a multisubstrate reaction system containing equimolar concentrations of 4-nitrophenyl esters (C4-C18). This assay is simple, reproducible, and a useful tool for determining chain length selectivity of lipases/esterases. PMID:24316114

  7. Development of a Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines Using a Microsphere-Flow Cytometry System

    OpenAIRE

    Laura P. Rodríguez; Vilariño, Natalia; Molgó, Jordi; Aráoz, Rómulo; Louzao, M. Carmen; Taylor, Palmer; Talley, Todd; Botana, Luis M.

    2013-01-01

    Biologically active macrocycles containing a cyclic imine were isolated for the first time from aquaculture sites in Nova Scotia, Canada, during the 1990s. These compounds display a “fast-acting” toxicity in the traditional mouse bioassay for lipophilic marine toxins. Our work aimed at developing receptor-based detection method for spirolides using a microsphere/flow cytometry Luminex system. For the assay two alternatives were considered as binding proteins, the Torpedo marmorata nicotinic a...

  8. Seismic safety margins research program. Phase I final report - Plant/site selection and data collection (Project I)

    International Nuclear Information System (INIS)

    Project I of Phase I of the Seismic Safety Margins Research Program (SSMRP) comprised two parts: the selection of a representative nuclear power plant/site for study in Phase I and the collection of data needed by the other SSMRP projects. Unit 1 of the Zion Nuclear Power Plant in Zion, Illinois, was selected for the SSMRP Phase I studies. Unit 1 of the Zion plant has been validated as a good choice for the Phase I study plant. Although no single nuclear power plant can represent all such plants equally well, selection criteria were developed to maximize the generic implications of Phase I of the SSMRP. On the basis of the selection criteria, the Zion plant and its site were found to be reasonably representative of operating and future plants with regard to its nuclear steam supply system; the type of containment structure (prestressed concrete); its electrical capacity (1100 MWe); its location (the Midwest); the peak seismic acceleration used for design (0.17g); and the properties of the underlying soil (the low-strain shear-wave velocity is 1650 ft/s in a 50- to 100-ft-thick layer of soil overlying sedimentary bedrock). (author)

  9. Radiopharmaceutical assays

    International Nuclear Information System (INIS)

    Under the laws in force, radiopharmaceuticals for human use must be among other features, non-pyrogenous and non-toxic. For this reason pyrogenity and toxicity assays are carried out. Pharmacokinetic studies may also be necessary in some cases. Products currently made at the Radiopharmaceutical Center, new products designed for certification and raw materials used to manufacture the above, were tested. A total 342 pyrogenity and toxicity tests, and four pharmacokinetic studies were conducted in 1996. To determine pyrogenity, the temperature animals were measured following intravenous administration of radiopharmaceuticals concerned: sodium pertechnetate, colloidal gold and sodium orthoradiohippurate from current production; pharmaceutic components of several new products, i.e. technetium generator, fibrinogen and microspheres. A total 327 products were tested, 96 percent of which met the requirements. To determine toxicity, the probit method was used, consisting of the administration of radiopharmaceutical doses for seven straight days, and checking for lethal effects. An overall 15 tests were carried out and 80 percent of products tested were found certifiable. Pharmacokinetic tests consisted of tropism on target organs and biodistribution in several organs using the tomographic method. (author)

  10. Introducing Environmental Toxicology in Instructional Labs: The Use of a Modified Amphibian Developmental Toxicity Assay to Support Inquiry-Based Student Projects

    Science.gov (United States)

    Sauterer, Roger; Rayburn, James R.

    2012-01-01

    Introducing students to the process of scientific inquiry is a major goal of high school and college labs. Environmental toxins are of great concern and public interest. Modifications of a vertebrate developmental toxicity assay using the frog Xenopus laevis can support student-initiated toxicology experiments that are relevant to humans. Teams of…

  11. Aberration measurement of projection optics in lithographic tools by use of an alternating phase-shifting mask

    International Nuclear Information System (INIS)

    As a critical dimension shrinks, the degradation in image quality caused by wavefront aberrations of projection optics in lithographic tools becomes a serious problem. It is necessary to establish a technique for a fast and accurate in situ aberration measurement. We introduce what we believe to be a novel technique for characterizing the aberrations of projection optics by using an alternating phase-shifting mask. The even aberrations, such as spherical aberration and astigmatism, and the odd aberrations, such as coma, are extracted from focus shifts and image displacements of the phase-shifted pattern, respectively. The focus shifts and the image displacements are measured by a transmission image sensor. The simulation results show that, compared with the accuracy of the previous straightforward measurement technique, the accuracy of the coma measurement increases by more than 30% and the accuracy of the spherical-aberration measurement increases by approximately 20%

  12. Aberration measurement of projection optics in lithographic tools by use of an alternating phase-shifting mask

    Science.gov (United States)

    Wang, Fan; Wang, Xiangzhao; Ma, Mingying; Zhang, Dongqing; Shi, Weijie; Hu, Jianming

    2006-01-01

    As a critical dimension shrinks, the degradation in image quality caused by wavefront aberrations of projection optics in lithographic tools becomes a serious problem. It is necessary to establish a technique for a fast and accurate in situ aberration measurement. We introduce what we believe to be a novel technique for characterizing the aberrations of projection optics by using an alternating phase-shifting mask. The even aberrations, such as spherical aberration and astigmatism, and the odd aberrations, such as coma, are extracted from focus shifts and image displacements of the phase-shifted pattern, respectively. The focus shifts and the image displacements are measured by a transmission image sensor. The simulation results show that, compared with the accuracy of the previous straightforward measurement technique, the accuracy of the coma measurement increases by more than 30% and the accuracy of the spherical-aberration measurement increases by approximately 20%.

  13. Russian energy efficiency projects: lessons learnt from Activities Implemented Jointly pilot phase

    International Nuclear Information System (INIS)

    Russia needs to improve the efficiency of energy. Failure to do so will retard the economic recovery of the country, but the energy sector is lacking both domestic and foreign investments. JI projects could provide the underfinanced Russian energy sector with additional investments. AIJ pilot project experiences provide an overview of the potential difficulties for future JI projects. Institutional problems were the most important category. Most of these problems remain, and the lack of ratification of the Kyoto Protocol by Russia has formed a new very significant barrier. Implementation level problems caused some problems to AIJ projects, but they are likely to have less impact on the better prepared JI projects. The character of funding-related problems has changed: for AIJ projects the main problem was that emission reductions could not be credited, whereas future JI projects will experience more competition in the Kyoto market where the overall investment climate and the availability of local cofunding are more relevant. Therefore, the unfinished economic and energy sector reforms currently discourage JI investments. The project experiences so far have been dismal, and if Russian policy-makers cannot improve this performance, only few JI projects can be expected in the future

  14. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Peru. August - October 1981

    International Nuclear Information System (INIS)

    The IUREP Orientation Phase Mission to Peru believes that the Speculative Resources of that country fall between 6,000 and 11,000 tonnes uranium. There has been no uranium production in Peru and there are no official estimates of uranium resources. Past exploration in Peru (dating from about 1952) has indicated a paucity of valid uranium occurrences and radioactive anomalies. Only recently (1980) have anomalous areas been identified, (Macusani-Picotani). The identified Speculative Resources are mainly in Late Tertiary ignimbrites and associated sediments in the high Andes of southern Peru. Geologically, there are direct parallels between these resources and deposits of the Los Frailes areas of neighbouring Bolivia. Other minor Speculative Resources may be present in calcretes developed from Tertiary volcanogenic sources over the Precambrian in the Pacific Coastal desert of southern Peru but no positive indications have been recognised. Hercynian sub-volcanic granites in the eastern cordillera of southern Peru may have some associated Speculative Resources both intra and extra granitic. No Speculative Potential could be identified in Permo-Triassic or Tertiary post tectonic continental sediments anywhere in Peru. Such potential may exist but further reconnaissance of the continental late Tertiary basins, with positive indications would be required before inclusion of potential in this category. Recent discoveries in the volcanogenic environment of southern Peru have been by carborne, helicopter borne and on on-foot reconnaissance of isolated areas. It is recommended that there be a more systematic, integrated study of the entire volcanic district assisted by volcanic petrographic examination. Assessment of the known occurrences requires immediate subsurface study by drilling and exploration audits to assess their continuity, grade variation and thickness. This phase will be significantly more expensive than previous exploration. Non-core drilling should supplement

  15. Assessing the Benefits of Social Networks for Organizations - Report on the first phase of the SEA-SoNS Project

    OpenAIRE

    MARTIN AARON KRISTOPHER; VAN BAVEL Rene

    2012-01-01

    The first phase of the SEA-SoNS ("Assessing the Benefits of Social Networks on Organizations”) project aimed to analyse the current market situation for a limited number of social media stakeholders, to identify and analyse best practices for these selected stakeholders, and to define and prioritise relevant policy options. It was observed that while social media technologies present several potential benefits to organisations, there are considerable challenges and bottlenecks affecting adopt...

  16. Analysis of Reasons for fluctuation in seal oil system on generator and countermeasures in Qinshan phase III project

    International Nuclear Information System (INIS)

    Reasons for hydraulic differential fluctuations seal hydrogen oil on generator in Qinshan phase III project were analyzed, provide a basis for modifying Run method is to determine the causes and effects of seal oil flow changes and in the relationship between flow changes and hydraulic differential hydrogen oil changes according to reason Results were analyzed to adjust the running test, to verify the feasibility of running adjustment programs

  17. Scientists help the children of Chernobyl. The GAST/VDEW project. Report on phase II: 1. April 1996 - 31. March 1998

    International Nuclear Information System (INIS)

    In this project phase II, from 1. April 1996 until 31. March 1998, the activities under the four partial projects entitled 'Therapy and training', 'Biological dosimetry', 'Dosimetry and risk assessment', and 'Coordination and examination authority at Minsk' have been continued and concluded, except for the partial project 'Therapy and training'. (orig./CB)

  18. QUEST2: Project plan for preliminary analysis/system architecture phase (PA/SA)

    Energy Technology Data Exchange (ETDEWEB)

    Braaten, F.D.

    1995-03-08

    This Project Management Plan combines the project management deliverables from the P+ methodology that are applicable to this part of the QUEST2 work. This consolidation reflects discussions with WHC QA regarding an appropriate method for ensuring that P+ deliverables fulfill the intent of WHC-CM-3-10 and QR-19.

  19. QUEST2: Project plan for preliminary analysis/system architecture phase (PA/SA)

    International Nuclear Information System (INIS)

    This Project Management Plan combines the project management deliverables from the P+ methodology that are applicable to this part of the QUEST2 work. This consolidation reflects discussions with WHC QA regarding an appropriate method for ensuring that P+ deliverables fulfill the intent of WHC-CM-3-10 and QR-19

  20. Comparison of electron microscopy, enzyme-linked immunosorbent assay, solid-phase radioimmunoassay, and indirect immunofluorescence for detection of human rotavirus antigen in faeces

    International Nuclear Information System (INIS)

    Four techniques were compared for their practicability, speed, and sensitivity for the detection of human rotavirus. Radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) were found to be the most sensitive means of identifying rotavirus and, once processed, up to 40 specimens could be examined daily. Electron microscopy, although less sensitive than these techniques, had the advantage of being able to detect other viral agents present in faecal extracts. Indirect immunofluorescence failed to detect rotavirus as often as the other three methods. In laboratories where routine examination of faecal specimens from patients with gastroenteritis is required, ELISA and RIA are useful alternatives to electron microscopy. (author)

  1. Phase One of a Project to Produce a Reference Grammar of Tamil. Final Report.

    Science.gov (United States)

    Ramanujan, A.K.

    This final report is a brief outline of Phase One in the preparation of a comprehensive reference grammar of Tamil, based on the results of recent linguistic theory and analytic techniques, and designed to be "accessible" to any student of Tamil. The studies which have resulted from Phase One are "strictly preliminary" to a larger study of the…

  2. Investigation of noise properties in grating-based x-ray phase tomography with reverse projection method

    Science.gov (United States)

    Bao, Yuan; Wang, Yan; Gao, Kun; Wang, Zhi-Li; Zhu, Pei-Ping; Wu, Zi-Yu

    2015-10-01

    The relationship between noise variance and spatial resolution in grating-based x-ray phase computed tomography (PCT) imaging is investigated with reverse projection extraction method, and the noise variances of the reconstructed absorption coefficient and refractive index decrement are compared. For the differential phase contrast method, the noise variance in the differential projection images follows the same inverse-square law with spatial resolution as in conventional absorption-based x-ray imaging projections. However, both theoretical analysis and simulations demonstrate that in PCT the noise variance of the reconstructed refractive index decrement scales with spatial resolution follows an inverse linear relationship at fixed slice thickness, while the noise variance of the reconstructed absorption coefficient conforms with the inverse cubic law. The results indicate that, for the same noise variance level, PCT imaging may enable higher spatial resolution than conventional absorption computed tomography (ACT), while ACT benefits more from degraded spatial resolution. This could be a useful guidance in imaging the inner structure of the sample in higher spatial resolution. Project supported by the National Basic Research Program of China (Grant No. 2012CB825800), the Science Fund for Creative Research Groups, the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant Nos. KJCX2-YW-N42 and Y4545320Y2), the National Natural Science Foundation of China (Grant Nos. 11475170, 11205157, 11305173, 11205189, 11375225, 11321503, 11179004, and U1332109).

  3. Application of lessons learned from Qinshan Phase III to a future project

    International Nuclear Information System (INIS)

    The Qinshan III Project achieved, through the use of advanced construction and project management tools and techniques and harmonious and cooperative relationships between project participants, first ranking international levels of nuclear project performance and quality, which include the shortest nuclear construction schedule in China and the shortest nuclear construction schedule for the first plant of a specific design in any country. The Qinshan III plant also incorporated the most advanced features of any CANDU plant, and, where objective measurements have been made, the highest quality achieved to date. Even though the Qinshan III Project achieved world-class performance, there is potential for further improvements to the plant design and project implementation, which could improve the cost, schedule, quality and national self-reliance. This paper describes and quantifies such potential improvements to assess their significance. For example, it is estimated that rearranging the schedule to take full advantage of the short component installation times and procurement times actually achieved on Qinshan III could shorten the construction schedule by as much as six months. Restructuring the project organization and scope splits to place more responsibility on Chinese organizations and reduce the scope performed by the foreign partners would result in improved costs and increased Chinese content. By adopting these measures, AECL estimates that: - The schedule could be reduced by six months, - The cost could be reduced by approximately 25%, and - Chinese content could be increased to over 50%. (author)

  4. Facilitating Client Value Creation in the Conceptual Design Phase of Construction Projects

    DEFF Research Database (Denmark)

    Thyssen, Mikael Hygum; Emmitt, Stephen; Bonke, Sten;

    2009-01-01

    If client values are not fully understood in a construction project it is likely to result in either low fulfilment of client expectations or multiple design alterations during the project process which lead to additional costs and frustration among the project participants. However, it is not a ...... incorporates client values into the conceptual design of construction projects. The workshop model draws on value management and lean thinking as underlying principles in an attempt to address the ambiguous concept of ‘value’.......If client values are not fully understood in a construction project it is likely to result in either low fulfilment of client expectations or multiple design alterations during the project process which lead to additional costs and frustration among the project participants. However, it is not a...... straightforward management task to operationalize client value in construction. Within this context, the client group comprises multiple stakeholders, which often have conflicting goals and values that may not be fully realized by the stakeholders themselves. The management challenge is further complicated by the...

  5. Reconstruction of gyrotropic phase-space distributions from one-dimensional projections

    DEFF Research Database (Denmark)

    Egedal, J.; Bindslev, H.

    2004-01-01

    This paper describes mathematical tools applicable to the reconstruction of anisotropic velocity distributions through the unfolding of data coming from techniques like collective Thomson scattering or laser induced fluorescence, where one-dimensional projections of the velocity space along...

  6. Tank waste remediation system privatization phase I infrastructure, project W-519, Quality Assurance implementation plan

    International Nuclear Information System (INIS)

    This document has been prepared to identify the quality requirements for all products/activities developed by or for Project W-519. This plan is responsive to the Numatec Hanford Corporation, Quality Assurance Program Plan, NHC-MP-001

  7. Waveguide Phase Modulator for Integrated Planar Lightwave Circuits in KTP Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase II effort proposes the development and integration of a Planar Lightwave Circuit (PLC) into an all fiber-based seed laser system used in high...

  8. Integrated Planar Lightwave Circuits for UV Generation and Phase Modulation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort proposes to establish the feasibility of developing a UV Planar Lightwave Circuit (PLC); a compact, highly efficient, waveguide-based...

  9. Fiber Optic Microcantilever Sensor Coupled with Reactive Polymers for Vapor Phase Detection of Ammonia Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Luna Innovations proposes to adapt its current aqueous-based, fiber-optic microcantilever sensor technology for real-time, monitoring of ammonia in air. Phase I...

  10. A Multi-Band Photonic Phased Array Antenna for High-Data Rate Communication Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Multi-band phased array antenna (PAA) can reduce the number of antennas on shipboard platforms while offering significantly improved performance. In order to steer...

  11. A Multi-band Photonic Phased Array Antenna for High-Date Rate Communication Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Multi-band phased array antenna (PAA) can reduce the number of antennas on shipboard platforms while offering significantly improved performance. In order to steer...

  12. SPS-ALPHA: The First Practical Solar Power Satellite via Arbitrarily Large PHased Array Project

    Data.gov (United States)

    National Aeronautics and Space Administration — SPS-ALPHA (Solar Power Satellite via Arbitrarily Large Phased Array) is a novel, bio-mimetic approach to the challenge of space solar power. If successful, this...

  13. Falsire: CSNI project for fracture analyses of large-scale international reference experiments (Phase 1). Comparison report

    International Nuclear Information System (INIS)

    A summary of the recently completed Phase I of the Project for Fracture Analysis of Large-Scale International Reference Experiments (Project FALSIRE) is presented. Project FALSIRE was created by the Fracture Assessment Group (FAG) of Principal Working Group No. 3 (PWG/3) of the OECD/NEA Committee on the Safety of Nuclear Installations (CSNI), formed to evaluate fracture prediction capabilities currently used in safety assessments of nuclear vessel components. The aim of the Project FALSIRE was to assess various fracture methodologies through interpretive analyses of selected large-scale fracture experiments. The six experiments used in Project FALSIRE (performed in the Federal Republic of Germany, Japan, the United Kingdom, and the U.S.A.) were designed to examine various aspects of crack growth in reactor pressure vessel (RPV) steels under pressurized-thermal-shock (PTS) loading conditions. The analysis techniques employed by the participants included engineering and finite-element methods, which were combined with Jr fracture methodology and the French local approach. For each experiment, analysis results provided estimates of variables such as crack growth, crack-mouth-opening displacement, temperature, stress, strain, and applied J and K values. A comparative assessment and discussion of the analysis results are presented; also, the current status of the entire results data base is summarized. Some conclusions concerning predictive capabilities of selected ductile fracture methodologies, as applied to RPVs subjected to PTS loading, are given, and recommendations for future development of fracture methodologies are made

  14. River Protection Project Integrated safety management system phase II verification report, volumes I and II - 8/19/99

    Energy Technology Data Exchange (ETDEWEB)

    SHOOP, D.S.

    1999-09-10

    The Department of Energy policy (DOE P 450.4) is that safety is integrated into all aspects of the management and operations of its facilities. In simple and straightforward terms, the Department will ''Do work safely.'' The purpose of this River Protection Project (RPP) Integrated Safety Management System (ISMS) Phase II Verification was to determine whether ISMS programs and processes are implemented within RFP to accomplish the goal of ''Do work safely.'' The goal of an implemented ISMS is to have a single integrated system that includes Environment, Safety, and Health (ES&H) requirements in the work planning and execution processes to ensure the protection of the worker, public, environment, and federal property over the RPP life cycle. The ISMS is comprised of the (1) described functions, components, processes, and interfaces (system map or blueprint) and (2) personnel who are executing those assigned roles and responsibilities to manage and control the ISMS. Therefore, this review evaluated both the ''paper'' and ''people'' aspects of the ISMS to ensure that the system is implemented within RPP. Richland Operations Office (RL) conducted an ISMS Phase I Verification of the TWRS from September 28-October 9, 1998. The resulting verification report recommended that TWRS-RL and the contractor proceed with Phase II of ISMS verification given that the concerns identified from the Phase I verification review are incorporated into the Phase II implementation plan.

  15. Fiber-optic link for the RF phase reference distribution system for the XFEL and TESLA projects

    Science.gov (United States)

    Czuba, Krzysztof; Eints, Frank; Felber, Matthias; Simrock, Stefan

    2005-02-01

    The UV Free-Electron Laser (UVFEL) and The TeV-Energy Superconducting Linear Accelerator (TESLA) projects will require phase synchronization of 0.1 ps short term (millisecond), 1 ps short term (minutes) and 10 ps long term (days). The stringent synchronization requirement of 10fs was given for the X-Ray Free- Electron Laser (XFEL). To fufill this requirement the XFEL may use a fiber laser as reference generator. But this requirement applies for a special location only, therefore the RF phase reference distribution system developed UVFEL and TESLA will also be used in the XFEL. The RF phase reference distribution system must deliver phase stable signals to hundreds of stations over a length of 33 km. Long, optical fiber based links are planned to be an important part of the entire distribution system. This paper describes the concept of a long optical link, with a feedback system suppressing long term drifts of the RF signal phase. Stability requirements are given and most important design issues affecting system performance are discussed. Finally, an experimental setup and measurement results demonstrating system performance is shown.

  16. Development of in vivo biotransformation enzyme assays for ecotoxicity screening: In vivo measurement of phases I and II enzyme activities in freshwater planarians.

    Science.gov (United States)

    Li, Mei-Hui

    2016-08-01

    The development of a high-throughput tool is required for screening of environmental pollutants and assessing their impacts on aquatic animals. Freshwater planarians can be used in rapid and sensitive toxicity bioassays. Planarians are known for their remarkable regeneration ability but much less known for their metabolic and xenobiotic biotransformation abilities. In this study, the activities of different phase I and II enzymes were determined in vivo by directly measuring fluorescent enzyme substrate disappearance or fluorescent enzyme metabolite production in planarian culture media. For phase I enzyme activity, O-deethylation activities with alkoxyresorufin could not be detected in planarian culture media. By contrast, O-deethylation activities with alkoxycoumarin were detected in planarian culture media. Increases in 7-ethoxycoumarin O-deethylase (ECOD) activities was only observed in planarians exposed to 1μM, but not 10μM, β-naphthoflavone for 24h. ECOD activity was inhibited in planarians exposed to 10 and 100μM rifampicin or carbamazepine for 24h. For phase II enzyme activity, DT-diaphorase, arylsulfatases, uridine 5'-diphospho (UDP)-glucuronosyltransferase or catechol-O-methyltransferase activity was determined in culture media containing planarians. The results of this study indicate that freshwater planarians are a promising model organism to monitor exposure to environmental pollutants or assess their impacts through the in vivo measurement of phase I and II enzyme activities. PMID:27062342

  17. HUMN project initiative and review of validation, quality control and prospects for further development of automated micronucleus assays using image cytometry systems

    Czech Academy of Sciences Publication Activity Database

    Fenech, M.; Kirsch-Volders, M.; Rössnerová, Andrea; Šrám, Radim; Romm, H.; Bolognesi, C.; Ramakumar, A.; Soussaline, F.; Schunck, CH.; Elhajouji, A.; Anwar, W.; Bonassi, S.

    2013-01-01

    Roč. 216, č. 5 (2013), s. 541-552. ISSN 1438-4639 R&D Projects: GA ČR GAP503/11/0084 Grant ostatní: Project NewGenesis(XE) FOOD -CT-2005-016320 Institutional support: RVO:68378041 Keywords : Micronucleus * Cytokinesis-block * Automation Subject RIV: DN - Health Impact of the Environment Quality Impact factor: 3.276, year: 2013

  18. Ecological evaluation of proposed discharge of dredged material from Oakland Harbor into ocean waters (Phase 3 of 38-Foot Project)

    Energy Technology Data Exchange (ETDEWEB)

    Ward, J.A.; Word, J.Q.; Pinza, M.R.; Mayhew, H.L.; Barrows, E.S.; Kohn, N.P.; Lefkovitz, L.F. (Battelle/Marine Sciences Lab., Sequim, WA (United States))

    1992-01-01

    At the request of the US Army Corps of Engineers (USACE), environmental studies were conducted by Battelle/Marine Science Laboratory (MSL) to evaluate the suitability of sediments from Oakland Inner Harbor for dredging and ocean disposal. During the Phase 3 38-Foot Project, sediment cores were collected from mudline to {minus}39 ft mean lower low water at various locations in Oakland Inner Harbor channel and allocated to six composite samples. These composites were evaluated through physical/chemical analyses, acute toxicity to sensitive marine organisms, and bioaccumulation potential. Sediment samples from individual locations were tested for physical/chemical parameters only. The results of toxicological and bioaccumulation testing may be used by USACE to determine the amount of potential dredged material from Oakland Inner Harbor channel acceptable for open-water disposal as defined by the Draft Implementation Manual (EPA/USACE 1990) and consistent with the Water Resources Development Act of 1986 (Public Law 99-662). This is Volume 2 of a two-volume data report that represents the data gathered during the Oakland Harbor Phase 3 38-Foot Project, conducted in the Fall of 1990. This data report does not include interpretation or statistical analysis of the 38-Foot data. Volume 1 includes the project background as well as data and results presented in Appendixes A through H. Volume 2 includes the remaining data presented in Appendixes I through L.

  19. Ecological evaluation of proposed discharge of dredged material from Oakland Harbor into ocean waters (Phase 3 of 38-Foot Project)

    Energy Technology Data Exchange (ETDEWEB)

    Ward, J.A.; Word, J.Q.; Pinza, M.R.; Mayhew, H.L.; Barrows, E.S.; Kohn, N.P.; Lefkovitz, L.F. (Battelle/Marine Sciences Lab., Sequim, WA (United States))

    1992-01-01

    At the request of the US Army Corps of Engineering (USACE), environmental studies were conducted by Battelle/Marine Sciences Laboratory (MSL) to evaluate the suitability of sediments from Oakland Inner Harbor for dredging and ocean disposal. During the Phase 3 38-Foot Project, sediment cores were collected from mudline to {minus}39 ft mean lower low water at various locations in Oakland Inner Harbor channel and allocated to six composite samples. These composites were evaluated through physical/chemical analyses, acute toxicity to sensitive marine organisms, and bioaccumulation potential. Sediment samples from individual locations were tested for physical/chemical parameters only. The results of toxicological and bioaccumulation testing may be used by USACE to determine the amount of potential dredged material from Oakland Inner Harbor channel acceptable for open-water disposal as defined by the Draft Implementation Manual (EPA/USACE 1990) and consistent with the Water Resources Development Act of 1986 (Public Law 99-662). This is Volume 1 of a two-volume data report that presents the data gathered during the Oakland Harbor Phase 3 38-Foot Project, conducted in the Fall of 1990. This data report does not include interpretation or statistical analysis of the 38-Foot data. Volume 1 includes the project background as well as a full presentation of data and results in Appendixes A through H. Volume 2 contains the remaining data in Appendixes I through L.

  20. Optimized projection binning for improved helical amplitude- and phase-based 4DCT reconstruction in the presence of breathing irregularity

    Science.gov (United States)

    Werner, René; Hofmann, Christian; Gauer, Tobias

    2016-03-01

    Respiration-correlated CT (4DCT) forms the basis of clinical 4D radiotherapy workflows for patients with thoracic and abdominal lesions. 4DCT image data, however, often suffers from motion artifacts due to unfulfilled assumptions during reconstruction and image/projection data sorting. In this work and focusing on low-pitch helical scanning protocols, two questionable assumptions are addressed: (1) the need for regular breathing patterns and (2) a constant correlation between the external breathing signal acquired for image/projection sorting and internal motion patterns. To counteract (1), a patient-specific upper breathing signal amplitude threshold is introduced to avoid artifacts due to unusual deep inspiration (helpful for both amplitude- and phase-based reconstruction). In addition, a projection data binning algorithm based on a statistical analysis of the patient's breathing signal is proposed to stabilize phase-based sorting. To further alleviate the need for (2), an image artifact metric is incorporated into and minimized during the reconstruction process. The optimized reconstruction is evaluated using 30 clinical 4DCT data sets and demonstrated to significantly reduce motion artifacts.

  1. Investigation of noise properties in grating-based x-ray phase tomography with reverse projection method

    Institute of Scientific and Technical Information of China (English)

    鲍园; 王研; 高昆; 王志立; 朱佩平; 吴自玉

    2015-01-01

    The relationship between noise variance and spatial resolution in grating-based x-ray phase computed tomography (PCT) imaging is investigated with reverse projection extraction method, and the noise variances of the reconstructed absorption coefficient and refractive index decrement are compared. For the differential phase contrast method, the noise variance in the differential projection images follows the same inverse-square law with spatial resolution as in conventional absorption-based x-ray imaging projections. However, both theoretical analysis and simulations demonstrate that in PCT the noise variance of the reconstructed refractive index decrement scales with spatial resolution follows an inverse linear relationship at fixed slice thickness, while the noise variance of the reconstructed absorption coefficient conforms with the inverse cubic law. The results indicate that, for the same noise variance level, PCT imaging may enable higher spatial resolution than conventional absorption computed tomography (ACT), while ACT benefits more from degraded spatial resolution. This could be a useful guidance in imaging the inner structure of the sample in higher spatial resolution.

  2. SOLERAS - Solar Controlled Environment Agriculture Project. Final report, Volume 9. Science Applications, Incorporated Phase 2 - definition study

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This report describes the effort required to implement the design of the Solar Controlled Environment Agriculture Engineering Test Facility, SCEA-ETF. This report is a basic blueprint for the Phase 2 activities which have as a goal the construction of the ETF. These activities have been broken down into five major tasks, namely Project Management; Engineering and Design; Procurement/Fabrication; Construction, Installation and Checkout; and Operation and Maintenance. The type of activities required under each of these tasks are described followed by a detailed work breakdown structure. The Phase 2 project organization is discussed. A 13 month schedule for the total project is also given. Lastly, two appendices discuss cost adjustment factors for an ETF located in the KSA, and an update of the commercial system cost estimate based on preliminary cost quotations for the ETF. The results show a 63% cost increase for the KSA ETF primarily due to higher construction costs and greater well depth. The commercial system cost required an adjustment upwards of 7.7%.

  3. Facilitating Client Value Creation in the Conceptual Design Phase of Construction Projects: A Workshop Approach

    Directory of Open Access Journals (Sweden)

    Mikael Hygum Thyssen

    2010-05-01

    Full Text Available If client values are not fully understood in a construction project it is likely to result in either low fulfilment of client expectations or multiple design alterations during the project process which lead to additional costs and frustration among the project participants. However, it is not a straightforward management task to operationalize client value in construction. Within this context, the client group comprises multiple stakeholders, which often have conflicting goals and values that may not be fully realized by the stakeholders themselves. The management challenge is further complicated by the fact that the delivery team, which is responsible for understanding and delivering client value, is made up of even more different parties. The article reports the initial outcome of a joint research project between academics and practitioners, which aims to develop a practical workshop model that incorporates client values into the conceptual design of construction projects. The workshop model draws on value management and lean thinking as underlying principles in an attempt to address the ambiguous concept of `value'. DOI: 10.3763/aedm.2008.0095

  4. Safety Culture in Pre-operational Phases of Nuclear Power Plant Projects

    International Nuclear Information System (INIS)

    An abundance of information exists on safety culture related to the operational phases of nuclear power plants; however, pre-operational phases present unique challenges. This publication focuses on safety culture during pre-operational phases that span the interval from before a decision to launch a nuclear power programme to first fuel load. It provides safety culture insights and focuses on eight generic issues: safety culture understanding; multicultural aspects; leadership; competencies and resource competition; management systems; learning and feedback; cultural assessments; and communication. Each issue is discussed in terms of: specific challenges; desired state; approaches and methods; and examples and resources. This publication will be of interest to newcomers and experienced individuals faced with the opportunities and challenges inherent in safety culture programmes aimed at pre-operational activities.

  5. An Algorithmic Form Of Verification Of Appointed Phases Of The Project Documentation For A Building Investment

    Science.gov (United States)

    Kochanek, Anna

    2015-12-01

    The process of area development and planning in compliance with conditions outlined in the Zoning Scheme is significant because of the current rapid development of rural and urban areas. The verification of project documentation in terms of observing constant and nationally binding norms, legislation and local laws is based on certain standards. In order to streamline the process of verification undertaken by the relevant public authorities, it is necessary to create formal algorithms that will automate the existing method of control of architecture-building documentation. The objective of this article is algorithmisation of the project documentation verification allowing further streamlining and automation of the process.

  6. Large volume injection of 1-octanol as sample diluent in reversed phase liquid chromatography: application in bioanalysis for assaying of indapamide in whole blood.

    Science.gov (United States)

    Udrescu, Stefan; Sora, Iulia Daniela; Albu, Florin; David, Victor; Medvedovici, Andrei

    2011-04-01

    Large volume injection of samples in strong diluents immiscible with the mobile phases used in reversed phase liquid chromatography (RPLC) has been recently introduced in practice. In the present work, the potential of the technique has been evaluated for bioanalytical applications. The process consists of the liquid-liquid extraction of indapamide from whole blood into 1-octanol, followed by the direct injection from the organic layer into the LC. Detection was made through negative electrospray ionization (ESI) and tandem mass spectrometry (MS(2)). The method was developed, validated, and successfully applied to a large number of samples in two bioequivalence studies designed for indapamide 1.5mg sustained release and 2.5mg immediate release pharmaceutical formulations. The performance of the analytical method is discussed based on data resulting from the validation procedure and the completion of the bioequivalence studies. PMID:21195573

  7. International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials

    OpenAIRE

    Galipeau, Jacques; Krampera, Mauro; Barrett, John; Dazzi, Francesco; Deans, Robert J.; Debruijn, Joost; Dominici, Massimo; Fibbe, Willem E.; Gee, Adrian P.; Gimble, Jeffery M.; Hematti, Peiman; Koh, Mickey B.C.; Leblanc, Katarina; Martin, Ivan; McNiece, Ian K.

    2015-01-01

    Mesenchymal stromal cells (MSCs) as a pharmaceutical for ailments characterized by pathogenic autoimmune, alloimmune and inflammatory processes now cover the spectrum of early- to late-phase clinical trials in both industry and academic sponsored studies. There is a broad consensus that despite different tissue sourcing and varied culture expansion protocols, human MSC-like cell products likely share fundamental mechanisms of action mediating their anti-inflammatory and tissue repair function...

  8. Independent Technical Review of the C-400 Interim Remedial Project Phase I Results, Paducah, Kentucky

    International Nuclear Information System (INIS)

    The groundwater and soil in the vicinity of the C-400 Building at the Paducah Gaseous Diffusion Plant (PGDP), is contaminated with substantial quantities of industrial solvents, primarily trichoroethene (TCE). This solvent 'source' is recognized as a significant challenge and an important remediation target in the overall environmental cleanup strategy for PGDP. Thus, the cleanup of the C-400 TCE Source is a principal focus for the Department of Energy (DOE) and its contractors, and for PGDP regulators and stakeholders. Using a formal investigation, feasibility study and decision process, Electrical Resistance Heating (ERH) was selected for the treatment of the soil and groundwater in the vicinity of C-400. ERH was selected as an interim action to remove 'a significant portion of the contaminant mass of TCE at the C-400 Cleaning Building area through treatment' with the longer term goal of reducing 'the period the TCE concentration in groundwater remains above its Maximum Contaminant Level (MCL).' ERH is a thermal treatment that enhances the removal of TCE and related solvents from soil and groundwater. The heterogeneous conditions at PGDP, particularly the high permeability regional gravel aquifer (RGA), are challenging to ERH. Thus, a phased approach is being followed to implement this relatively expensive and complex remediation technology. Conceptually, the phased approach encourages safety and efficiency by providing a 'lessons learned' process and allowing appropriate adjustments to be identified and implemented prior to follow-on phase(s) of treatment. More specifically, early deployment targeted portions of the challenging RGA treatment zone with relatively little contamination reducing the risk of adverse collateral impacts from underperformance in terms of heating and capture. Because of the importance and scope of the C-400 TCE source remediation activities, DOE chartered an Independent Technical Review (ITR) in 2007 to assess the C-400 ERH plans prior

  9. INDEPENDENT TECHNICAL REVIEW OF THE C-400 INTERIM REMEDIAL PROJECT PHASE I RESULTS, PADUCAH, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Rossabi, J.; Stewart,L.; Richards, W.

    2010-10-29

    The groundwater and soil in the vicinity of the C-400 Building at the Paducah Gaseous Diffusion Plant (PGDP), is contaminated with substantial quantities of industrial solvents, primarily trichoroethene (TCE). This solvent 'source' is recognized as a significant challenge and an important remediation target in the overall environmental cleanup strategy for PGDP. Thus, the cleanup of the C-400 TCE Source is a principal focus for the Department of Energy (DOE) and its contractors, and for PGDP regulators and stakeholders. Using a formal investigation, feasibility study and decision process, Electrical Resistance Heating (ERH) was selected for the treatment of the soil and groundwater in the vicinity of C-400. ERH was selected as an interim action to remove 'a significant portion of the contaminant mass of TCE at the C-400 Cleaning Building area through treatment' with the longer term goal of reducing 'the period the TCE concentration in groundwater remains above its Maximum Contaminant Level (MCL).' ERH is a thermal treatment that enhances the removal of TCE and related solvents from soil and groundwater. The heterogeneous conditions at PGDP, particularly the high permeability regional gravel aquifer (RGA), are challenging to ERH. Thus, a phased approach is being followed to implement this relatively expensive and complex remediation technology. Conceptually, the phased approach encourages safety and efficiency by providing a 'lessons learned' process and allowing appropriate adjustments to be identified and implemented prior to follow-on phase(s) of treatment. More specifically, early deployment targeted portions of the challenging RGA treatment zone with relatively little contamination reducing the risk of adverse collateral impacts from underperformance in terms of heating and capture. Because of the importance and scope of the C-400 TCE source remediation activities, DOE chartered an Independent Technical Review (ITR) in

  10. Aptamer-based fluorescent solid-phase thrombin assay using a silver-coated glass substrate and signal amplification by glucose oxidase

    International Nuclear Information System (INIS)

    We describe an aptamer-based solid-state biosensor for the fluorometric determination of thrombin. The surface of silver-coated glass was modified with the thrombin-binding aptamer 1 (TBA 1) of the sequence 5′-HS-TTT TTT TTT TTT TTT GGT TGG TGT GGT TGG-3′. A second (and biotinylated) thrombin -binding aptamer (TBA 2) with the sequence 5′-biotin-AGT CCG TGG TAG GGC AGG TTG GGG TGA CT-3′ was applied as the signaling aptamer. Following binding of thrombin by TBA 1 on the surface, TBA 2 is added and then binds to the thrombin on the surface of the silver-coated glass to form the thrombin-aptamer complex. The biotin groups on TBA 2 are then coated with streptavidin, and biotin-labeled glucose oxidase (biotin-GOx) is added to bind to streptavidin. The quantity of GOx immobilized in this way is directly related to the quantity of thrombin bound on the surface. Following cleavage of the aptamer with DNase I, glucose is added and oxidized by GOx to yield H2O2. Horseradish peroxidase is added and causes the oxidation of 3-p-hydroxyphenylpropanoic acid to yield a fluorescent product. The intensity of the blue fluorescence is directly related to the thrombin concentration in the 300 pM to 6500 pM range, and the detection limit is as low as 82 pM. The assay has good selectivity and practicability. (author)

  11. Phase V storage (Project W-112) Central Waste Complex operational readiness review, final report

    International Nuclear Information System (INIS)

    This document is the final report for the RFSH conducted, Contractor Operational Readiness Review (ORR) for the Central Waste Complex (CWC) Project W-112 and Interim Safety Basis implementation. As appendices, all findings, observations, lines of inquiry and the implementation plan are included

  12. Phase 2 Reese River Geothermal Project Slim Well 56-4 Drilling and Testing

    Energy Technology Data Exchange (ETDEWEB)

    Henkle, William R.; Ronne, Joel

    2008-06-15

    This report covers the drilling and testing of the slim well 56-4 at the Reese River Geothermal Project in Lander County, Nevada. This well was partially funded through a GRED III Cooperative Funding Agreement # DE-FC36-04GO14344, from USDOE.

  13. Phase 5 storage (Project W-112) Central Waste Complex operational readiness review, final report

    Energy Technology Data Exchange (ETDEWEB)

    Wight, R.H.

    1997-05-30

    This document is the final report for the RFSH conducted, Contractor Operational Readiness Review (ORR) for the Central Waste Complex (CWC) Project W-112 and Interim Safety Basis implementation. As appendices, all findings, observations, lines of inquiry and the implementation plan are included.

  14. 75 FR 39042 - Solicitation for a Cooperative Agreement: The Norval Morris Project Implementation Phase

    Science.gov (United States)

    2010-07-07

    ... Norval Morris and other NIC sponsored projects on organizational culture and performance, implementing... intervention test, including assessing readiness for change; (4) assist each site, in concert with NIC, in... to promote systemic change in an agency by addressing concrete problems such as population...

  15. D-Area Drip Irrigation/Phytoremediation Project: SRTC Report on Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Wilde, E.W.

    2001-09-11

    The overall objective of this project is to evaluate a novel drip irrigation-phytoremediation process for remediating volatile organic contaminants (VOCs), primarily trichloroethylene (TCE), from groundwater in D-Area at the Savannah River Site (SRS). The process is expected to be less expensive and more beneficial to the environment than alternative TCE remediation technologies.

  16. Socio-economic Analysis of the Beijing-Tianjin Sandstorm Source Control Project Phase

    Institute of Scientific and Technical Information of China (English)

    Zhangfenglai

    2012-01-01

    With the purpose of improving the air quality as well as curbing sand and dust hazard in the Beijing-Tianjin Area,our country urgently started Beijing-Tianjin Sandstorm Source Control Project in 2000,which,more then ten years' construction,has achieved enormous social,economic and ecological results.

  17. Use of Social Network Analysis in Early Phases of ICT Projects

    Directory of Open Access Journals (Sweden)

    Libor Mesicek

    2012-07-01

    Full Text Available According to results of our surveys in 2011 the ICT project managers operating in the Czech Republic would like to have wider possibility of influencing the selection of team members in their projects.The article focuses on the psychological and the sociological aspects of the ICT project teams’ structure, analyzing the existing social networks within a company as well as the concept of the team roles when setting up the project team by mapping the existing relationships among the team members and the possible personality divergence of each employee.The first part of the article summarizes the important milestones for mapping the social networks, the possibility of mapping the network of social relationships, communication channels and relationships in the company, it is focusing on the differences between a team and a work group and the consequences on their functioning.The article represents two surveys results. First one took place among 36 ICT project managers and the second one among visitors of international conference Systems integration 2011. Based on these results, we are presenting a brief description of process design that supports and is important for the ICT team leader’s nominations, as well as for the ICT team members, respecting their relationship structure, results of past cooperation and psychological team roles.The process includes a mapping of a subset of social networks, recommendations of competent managers for the approved project charters based on the output of the analysis, progress and outcomes of finished projects and other relevant business information. The following stage carries the selection and recommendation for individual leaders in regards of the appropriate team members. To ensure the continuous process improvement and preservation of knowledge for the next cycle, the last part is completed by the feedback and evaluation. The proposed process cycle should stress the importance of psychological and

  18. Navy Radon Assessment and Mitigation Program: Work/quality assurance project plan screening phase

    International Nuclear Information System (INIS)

    In 1987, the military services of the United States were tasked to take appropriate action to establish an indoor radon assessment and mitigation program. As a result, the Naval Facilities Engineering Command (NAVFACENGCOM) was assigned the responsibility of identifying potential hazards to personnel from exposure to naturally occurring radon gas and prioritizing corrective actions and to coordinating these actions with the major claimants. NAVRAMP is based upon current US Environmental Protection Agency (EPA) guidelines. The program has been separated into four phases. The screening phase will concentrate on evaluating radon levels, based on statistical samples, in those buildings that have been determined to be at most at risk to elevated levels of radon, such as base housing, schools, day-care centers, hospitals, brigs, Base Officer Quarters, and Base Enlisted Quarters. During the assessment phase, every building that contains personnel for over 4 h/day will be evaluated. Mitigation work will be accomplished by Navy or Navy-contracted personnel. HAZWRAP services during the mitigation phase will consist of determining the extent of reduction in radon levels after the mitigation effort. 7 refs., 11 figs

  19. Taking Ultra-Wideband Communications To The Next Phase Is The Goal Of Virginia Tech Project

    OpenAIRE

    Crumbley, Liz

    2003-01-01

    A team of Virginia Tech researchers is attempting to push ultra-wideband (UWB) technology into the next phase--where military communications can completely elude detection by nearby enemy troops and all manner of home electronics systems can be operated wirelessly.

  20. DECOVALEX-THMC Project. Task B. Understanding and characterizing the excavation disturbed zone (EDZ). Phase 2 Report

    International Nuclear Information System (INIS)

    The DECOVALEX-THMC project is an ongoing international co-operative project that was stared in 2004 to support the development of mathematical models of coupled Thermal (T), Hydrological (H), Mechanical (M) and Chemical (C) processes in geological media for siting potential nuclear fuel waste repositories. The general objective is to characterise and evaluate the coupled THMC processes in the near field and far field of a geological repository and to assess their impact on performance assessment: - during the three phases of repository development: excavation phase, operation phase and post-closure phase; - for three different rocks types: crystalline, argillaceous and tuff; - with specific focus on the issues of: Excavation Damaged Zone (EDZ), permanent property changes of rock masses, and glaciation and permafrost phenomena. The project involves a large number of research teams supported by radioactive waste management agencies or governmental regulatory bodies in Canada, China, Finland, France, Germany, Japan, Sweden and USA, who conducted advanced studies and numerical modelling of coupled THMC processes under five tasks. This report summarizes the work contributed to Phase 2 of Task B of the project, which took place during the period of March 2004 to May 2006. The Phase 2 work incorporated the use of a wide range of numerical models to simulate the failure of a number of intact rock core samples, from the APSE tunnel at Aespoe HRL, as tested in uniaxial compression and other loading conditions with the intention of establishing the common and code-specific features of the models. The core samples of the Aespoe diorite were treated with different initial mechanical and chemical conditions as dry samples, saturated with distilled water, formation water and saline water, with different durations of submersion, respectively, in order to observe the mechanical effects of saturation by different chemical fluids on the mechanical properties of the intact core

  1. NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 7:Summary report to phase 2 respondents including frequency distributions

    Science.gov (United States)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.

    1991-01-01

    Phase 2 of the four phase NASA/DoD Aerospace Knowledge Diffusion Research Project was undertaken to study the transfer of scientific and technical information (STI) from government to the aerospace industry and the role of librarians and technical information specialists in the transfer process. Data was collected through a self-administered mailback questionnaire. Libraries identified as holding substantial aerospace or aeronautical technical report collections were selected to receive the questionnaires. Within each library, the person responsible for the technical report was requested to answer the questionnaire. Questionnaires were returned from approx. 68 pct. of the libraries. The respondents indicated that scientists and engineer are not aware of the services available from libraries/technical information centers and that scientists and engineers also under-utilized their services. The respondents also indicated they should be more involved in the process.

  2. DECOVALEX-THMC Project. Task B. Understanding and characterizing the excavation disturbed zone (EDZ). Phase 2 Report

    Energy Technology Data Exchange (ETDEWEB)

    Hudson, John A. (ed.) [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)]|[Rock Engineering Consultants (United Kingdom); Lanru Jing (ed.) [Royal Institute of Technology, Stockholm (Sweden); Antikainen, Juha [Helsinki University of Technology, Helsinki (Finland); Backers, Tobias [GeoFrames GmbH, (Germany); Baeckstroem, Ann [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)]|[Bergbyggkonsult AB (Sweden); Koyama, Tomofumi [Swedish Nuclear Power Inspectorate, Stockholm (Sweden); Xiating Feng; Pengzhi Pan [Chinese Academy of Sciences (China); Kobayashi, Akira [Kyoto Univ. (Japan); Rinne, Mikael; Baotang Shen [Fracom Ltd. (Finland)

    2007-02-15

    The DECOVALEX-THMC project is an ongoing international co-operative project that was stared in 2004 to support the development of mathematical models of coupled Thermal (T), Hydrological (H), Mechanical (M) and Chemical (C) processes in geological media for siting potential nuclear fuel waste repositories. The general objective is to characterise and evaluate the coupled THMC processes in the near field and far field of a geological repository and to assess their impact on performance assessment: - during the three phases of repository development: excavation phase, operation phase and post-closure phase; - for three different rocks types: crystalline, argillaceous and tuff; - with specific focus on the issues of: Excavation Damaged Zone (EDZ), permanent property changes of rock masses, and glaciation and permafrost phenomena. The project involves a large number of research teams supported by radioactive waste management agencies or governmental regulatory bodies in Canada, China, Finland, France, Germany, Japan, Sweden and USA, who conducted advanced studies and numerical modelling of coupled THMC processes under five tasks. This report summarizes the work contributed to Phase 2 of Task B of the project, which took place during the period of March 2004 to May 2006. The Phase 2 work incorporated the use of a wide range of numerical models to simulate the failure of a number of intact rock core samples, from the APSE tunnel at Aespoe HRL, as tested in uniaxial compression and other loading conditions with the intention of establishing the common and code-specific features of the models. The core samples of the Aespoe diorite were treated with different initial mechanical and chemical conditions as dry samples, saturated with distilled water, formation water and saline water, with different durations of submersion, respectively, in order to observe the mechanical effects of saturation by different chemical fluids on the mechanical properties of the intact core

  3. JCCRER Project 2.3 -- Deterministic effects of occupational exposure to radiation. Phase 1: Feasibility study; Final report

    Energy Technology Data Exchange (ETDEWEB)

    Okladnikova, N.; Pesternikova, V.; Sumina, M. [Inst. of Biophysics, Ozyorsk (Russian Federation)] [and others

    1998-12-01

    Phase 1 of Project 2.3, a short-term collaborative Feasibility Study, was funded for 12 months starting on 1 February 1996. The overall aim of the study was to determine the practical feasibility of using the dosimetric and clinical data on the MAYAK worker population to study the deterministic effects of exposure to external gamma radiation and to internal alpha radiation from inhaled plutonium. Phase 1 efforts were limited to the period of greatest worker exposure (1948--1954) and focused on collaboratively: assessing the comprehensiveness, availability, quality, and suitability of the Russian clinical and dosimetric data for the study of deterministic effects; creating an electronic data base containing complete clinical and dosimetric data on a small, representative sample of MAYAK workers; developing computer software for the testing of a currently used health risk model of hematopoietic effects; and familiarizing the US team with the Russian diagnostic criteria and techniques used in the identification of Chronic Radiation Sickness.

  4. JCCRER Project 2.3 - Deterministic effects of occupational exposure to radiation. Phase 1: Feasibility study. Final report

    International Nuclear Information System (INIS)

    Phase 1 of Project 2.3, a short-term collaborative Feasibility Study, was funded for 12 months starting on 1 February 1996. The overall aim of the study was to determine the practical feasibility of using the dosimetric and clinical data on the MAYAK worker population to study the deterministic effects of exposure to external gamma radiation and to internal alpha radiation from inhaled plutonium. Phase 1 efforts were limited to the period of greatest worker exposure (1948--1954) and focused on collaboratively: assessing the comprehensiveness, availability, quality, and suitability of the Russian clinical and dosimetric data for the study of deterministic effects; creating an electronic data base containing complete clinical and dosimetric data on a small, representative sample of MAYAK workers; developing computer software for the testing of a currently used health risk model of hematopoietic effects; and familiarizing the US team with the Russian diagnostic criteria and techniques used in the identification of Chronic Radiation Sickness

  5. Uncovering a Salt Giant. Deep-Sea Record of Mediterranean Messinian Events (DREAM) multi-phase drilling project

    Science.gov (United States)

    Camerlenghi, Angelo; Aoisi, Vanni; Lofi, Johanna; Hübscher, Christian; deLange, Gert; Flecker, Rachel; Garcia-Castellanos, Daniel; Gorini, Christian; Gvirtzman, Zohar; Krijgsman, Wout; Lugli, Stefano; Makowsky, Yizhaq; Manzi, Vinicio; McGenity, Terry; Panieri, Giuliana; Rabineau, Marina; Roveri, Marco; Sierro, Francisco Javier; Waldmann, Nicolas

    2014-05-01

    In May 2013, the DREAM MagellanPlus Workshop was held in Brisighella (Italy). The initiative builds from recent activities by various research groups to identify potential sites to perform deep-sea scientific drilling in the Mediterranean Sea across the deep Messinian Salinity Crisis (MSC) sedimentary record. In this workshop three generations of scientists were gathered: those who participated in formulation of the deep desiccated model, through DSDP Leg 13 drilling in 1973; those who are actively involved in present-day MSC research; and the next generation (PhD students and young post-docs). The purpose of the workshop was to identify locations for multiple-site drilling (including riser-drilling) in the Mediterranean Sea that would contribute to solve the several open questions still existing about the causes, processes, timing and consequences at local and planetary scale of an outstanding case of natural environmental change in the recent Earth history: the Messinian Salinity Crisis in the Mediterranean Sea. The product of the workshop is the identification of the structure of an experimental design of site characterization, riser-less and riser drilling, sampling, measurements, and down-hole analyses that will be the core for at least one compelling and feasible multiple phase drilling proposal. Particular focus has been given to reviewing seismic site survey data available from different research groups at pan-Mediterranean basin scale, to the assessment of additional site survey activity including 3D seismics, and to ways of establishing firm links with oil and gas industry. The scientific community behind the DREAM initiative is willing to proceed with the submission to IODP of a Multi-phase Drilling Project including several drilling proposals addressing specific drilling objectives, all linked to the driving objectives of the MSC drilling and understanding . A series of critical drilling targets were identified to address the still open questions

  6. Prototypical Rod Consolidation Demonstration Project. Phase 3, Final report: Volume 1, Cold checkout test report, Book 4

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The objective of Phase 3 of the Prototypical Rod consolidation Demonstration Project (PRCDP) was to procure, fabricate, assemble, and test the Prototypical Rod consolidation System as described in the NUS Phase 2 Final Design Report. This effort required providing the materials, components, and fabricated parts which makes up all of the system equipment. In addition, it included the assembly, installation, and setup of this equipment at the Cold Test Facility. During the Phase 3 effort the system was tested on a component, subsystem, and system level. This volume 1, discusses the PRCDP Phase 3 Test Program that was conducted by the HALLIBURTON NUS Environmental Corporation under contract AC07-86ID12651 with the United States Department of Energy. This document, Volume 1, Book 4 discusses the following topics: Rod Compaction/Loading System Test Results and Analysis Report; Waste Collection System Test Results and Analysis Report; Waste Container Transfer Fixture Test Results and Analysis Report; Staging and Cutting Table Test Results and Analysis Report; and Upper Cutting System Test Results and Analysis Report.

  7. Robust initialization of 2D-3D image registration using the projection-slice theorem and phase correlation

    International Nuclear Information System (INIS)

    Purpose: The image registration literature comprises many methods for 2D-3D registration for which accuracy has been established in a variety of applications. However, clinical application is limited by a small capture range. Initial offsets outside the capture range of a registration method will not converge to a successful registration. Previously reported capture ranges, defined as the 95% success range, are in the order of 4-11 mm mean target registration error. In this article, a relatively computationally inexpensive and robust estimation method is proposed with the objective to enlarge the capture range. Methods: The method uses the projection-slice theorem in combination with phase correlation in order to estimate the transform parameters, which provides an initialization of the subsequent registration procedure. Results: The feasibility of the method was evaluated by experiments using digitally reconstructed radiographs generated from in vivo 3D-RX data. With these experiments it was shown that the projection-slice theorem provides successful estimates of the rotational transform parameters for perspective projections and in case of translational offsets. The method was further tested on ex vivo ovine x-ray data. In 95% of the cases, the method yielded successful estimates for initial mean target registration errors up to 19.5 mm. Finally, the method was evaluated as an initialization method for an intensity-based 2D-3D registration method. The uninitialized and initialized registration experiments had success rates of 28.8% and 68.6%, respectively. Conclusions: The authors have shown that the initialization method based on the projection-slice theorem and phase correlation yields adequate initializations for existing registration methods, thereby substantially enlarging the capture range of these methods.

  8. The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

    NARCIS (Netherlands)

    Vinken, M.; Doktorova, T.; Ellinger-Ziegelbauer, H.; Ahr, H.-J.; Lock, E.; Carmichael, P.; Roggen, E.; Delft, J. van; Kleinjans, J.; Castell, J.; Bort, R.; Donato, T.; Ryan, M.; Corvi, R.; Keun, H.; Ebbels, T.; Athersuch, T.; Sansone, S.-A.; Rocca-Serra, P.; Stierum, R.; Jennings, P.; Pfaller, W.; Gmuender, H.; Vanhaecke, T.; Rogiers, V.

    2008-01-01

    Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to deve

  9. CEC project Mirage - second phase on migration of radionuclides in the geosphere. Third (and final) summary progress report (work period 1989)

    International Nuclear Information System (INIS)

    A second phase of the Community coordinated project Mirage (migration of radionuclides in the geosphere) was launched in 1986. The present report brings together reviews of work done in the four research areas of this phase for 1989, and therefore constitutes an update of the previous reports, ref. EUR 11589 and 12229. This project is part of the CEC R and D programme on radioactive waste management (1985-89)

  10. Planning and reporting of Russian transmutation research projects within ISTC. Phase 1

    International Nuclear Information System (INIS)

    The International Scientific and Technical Center (ISTC) in Moscow funds research of civil interest to counteract the risk of nuclear weapon proliferation. Recently, new technical concepts, Accelerator Transmutation of Nuclear Waste (ATW), have been proposed to incinerate and transmute long-lived radioactive nuclear waste to relax the time needed to store the waste in a geological repository. The Russian experts are knowledgeable and well equipped for doing research in the different technical fields of relevance for the transmutation concepts. Thus, a number of ISTC projects have been proposed to investigate different technical aspects of ATW with a result that a fair number of former weapon specialists have converted from military to peaceful civilian research. The present report describes the back ground, the status and near term activities of a few ISTC projects of relevance for the ATW concept, which are planned with the participation of a Swedish reference group. 4 refs

  11. Roadway Powered Electric Vehicle Project Track Construction And Testing Program Phase 3D

    OpenAIRE

    Systems Control Technology, Inc.

    1994-01-01

    This report covers the construction and testing of a Roadway Powered Electric Vehicle (RPEV) proof-of-concept system. The test facility was built at the University of California Richmond Field Station. The facility has a 700-foot test track and an operational 35-passenger RPEV. The report contains an introduction to the concept of RPEV and discusses the following aspects of the project: systems engineering and design, vehicle, facilities, testing, related RPEV research, and control circuits.

  12. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Ghana. Draft

    International Nuclear Information System (INIS)

    The Republic of Ghana has no claimed uranium resources in the categories Reasonably Assured and Estimated Additional. The only occurrences known are within pegmatites and are of no economic importance. The IUREP Orientation Phase Mission to Ghana estimates that the Speculative Resources of the country fall between 15,000 and 40,000 tonnes uranium. The IUREP Orientation Phase Mission to Ghana believes that the Panafrican Mobile Belt has the highest uranium potential of all geological units of the country. The Obosum beds are the priority number two target. A three years exploration programme is recommended for a total cost of US $ 5,000,000. The Ghana Atomic Energy Commission and the Ghana Geological Survey provide a basic infrastructure for uranium exploration. Any future uranium development in Ghana should be embedded in a well defined national uranium policy. It is recommended that such a policy be draw, up by the Ghanaian authorities

  13. Final environmental assessment for the Liquid Phase Methanol (LPMEOH trademark) Project

    International Nuclear Information System (INIS)

    The proposed project is to demonstrate on a commercial scale the production of methanol from coal-derived synthesis gas using the LPMEOH trademark process. The methanol produced during this demonstration will be used as a chemical feedstock (on-site) and/or as an alternative fuel in stationary and transportation applications (off-site). In addition, the production of dimethyl ether (DME) as a mixed co-product with methanol may be demonstrated for a six month period under the proposed project pending the results of laboratory/pilot-scale research on scale-up. The DME would be used as fuel in on-site boilers. The proposed LPMEOH facility would occupy approximately 0.6 acres of the 3,890-acre Eastman Chemical facility in Kingsport, TN. The effects of the proposed project include changes in air emissions, wastewater discharge, cooling water discharge, liquid waste quantities, transportation activities, socioeconomic effects, and quantity of solids for disposal. No substantive negative impacts or environmental concerns were identified

  14. Supplmental design requirements document enhanced radioactive and mixed waste storage: Phase 5, Project W-113

    International Nuclear Information System (INIS)

    This Supplemental Design Requirements Document (SDRD) is used to communicate Project W-113 specific plant design information from Westinghouse Hanford Company (WHC) to the United States Department of Energy (DOE) and the cognizant Architect Engineer (A/E). The SDRD is prepared after the completion of the project Conceptual Design report (CDR) and prior to the initiation of definitive design. Information in the SDRD serves two purposes: to convey design requirements that are too detailed for inclusion in the Functional Design Criteria (FDC) report and to serve as a means of change control for design commitments in the Title I and Title II design. The Solid Waste Retrieval Project (W-113) SDRD has been restructured from the equipment based outline used in previous SDRDs to a functional systems outline. This was done to facilitate identification of deficiencies in the information provided in the initial draft SDRD and aid design confirmation. The format and content of this SDRD adhere as closely as practicable to the requirements of WHC-CM-6-1, Standard Engineering Practices for Functional Design Criteria

  15. Metholology for the selection of LWR safety R and D projects. Phase I, status report

    International Nuclear Information System (INIS)

    The objective of the LWR R and D Selection Methodology Program is to develop and demonstrate an R and D selection methodology appropriate for LWR safety technology. This report documents the development work from the program beginning in April, 1979 to the end of Fiscal Year 1979. The scope of work for this period included three tasks; methodology review (Task 1), measures development (Task 2), and methodology development for the first phase of application (Task 3). The accomplishments of these tasks are presented

  16. Lifecycle information for E-literature: an introduction to the second phase of the LIFE project

    OpenAIRE

    Ayris, P.; R Davies; McLeod, R; Miao, R.; Shenton, H.; P. Wheatley(University of Warwick, United Kingdom)

    2008-01-01

    Introduction: The first phase of LIFE (Lifecycle Information For E-Literature) made a major contribution to understanding the long-term costs of digital preservation; an essential step in helping institutions plan for the future. The LIFE work models the digital lifecycle and calculates the costs of preserving digital information for future years. Organisations can apply this process in order to understand costs and plan effectively for the preservation of their digital collection...

  17. Fish tracking technology development. Phases 1 and 2, project definition desk study and equipment

    OpenAIRE

    Moore, A.; Potter, E.C.E.; Elson, J

    1997-01-01

    The document reports on the major findings from a definition study to appraise the options to develop fish tracking equipment, in particular tags and data logging systems, in order to improve the effeciency of the Agency tracking studies and to obtain a greater understanding of fish biology. The definition study was in two parts. The first, Phase 1, collated and evaluated all the known tracking systems that may be suitable for studies of fish which are either produced commercially or have bee...

  18. The SKI-project External events - Phase 2. Estimation of fire frequencies per plant and per building

    International Nuclear Information System (INIS)

    The Swedish-Finnish handbook for initiating event frequencies, I-Book, does not contain any fire frequencies. This matter of fact is not defensible considering the substantial risk contribution caused by fires. In the PSAs performed hitherto the initiating fire frequencies have been determined from case to case. Because data are usually very scarce in these areas it is very important to develop unique definitions, to systematically utilize both international and national experiences and to establish an appropriate statistical estimation method. It is also important to present the accumulated experience such that it can be used for different purposes, not only within PSA but also in the concrete fire preventive work. During phase 1 of the project External Events an inventory was made of existing methods for probabilistic fire analysis in general. During phase 2 of the project it was decided to initialize the work on a complementary handbook, called X-Book, in order to encompass the frequencies of system external events, i.e. initiating events that are caused by events occurring outside the system boundaries. In Version 1 of the X-Book the attention is mainly focussed on the estimation of initiating fire frequencies, per plant and per building. This estimation is basically founded on reports that the power companies have collected for this specific purpose. This report describes the statistical model and method that have been used in the estimation process. The methodological results achieved may, possibly after some modification, be applicable also to other types of system external events

  19. Analysis of the Emission Inventories and Model-Ready Emission Datasets of Europe and North America for Phase 2 of the AQMEII Project

    Science.gov (United States)

    This paper highlights the development of the emission inventories and emission processing for Europe (EU) and North America (NA) in the second phase of the Air Quality Model Evaluation International Initiative (AQMEII) project. The main purpose of the second phase of the AQMEII...

  20. State of Nevada review of Phase 1 of the INTRAVAL Project

    International Nuclear Information System (INIS)

    The INTRAVAL Project which started in October, 1987, was designed to be an international cooperation project and is managed by the Swedish Nuclear Power Inspectorate. The project was to undertake the issue of what constitutes a validated model in terms of repository performance assessment. The US Nuclear Regulatory Commission (NRC) in 10CFR60.21 requires an explanation of measures used to support the models utilized in the assessment of performance which are included in the License Application. The NRC Nureg 0856, ''Final Technical Position on Documentation of Computer Codes for High Level Waste Management'' defines the term validation to be, ''assurance that a model as embodied in a computer code is a correct representation of the process or system for which it is intended. The notion of validating that a code accurately represents the operational physical processes at a given site has turned out to be a very difficult endeavor. Especially for sites such as Yucca Mountain where the flow regime is poorly known. There is currently no mathematical description of unsaturated flow in fractured -- porous media which the majority of the scientific community can support with confidence. Further, all overall performance calculations performed to date by the US DOE assume one dimensional porous flow which enters through the top of Yucca Mountain and makes it way to and through the repository. Not surprisingly these types of calculations lead to the conclusion that little or no release is possible via the groundwater pathway. Quite naturally, the State of Nevada is concerned with these types of calculations, preferring to see something more realistic in terms of conceptual models, fracture pathways, and releases. This concern is carried into the INTRAVAL process because if the DOE is to validate a model of flow at Yucca Mountain within INTRAVAL, the model must be realistic

  1. Agricultural Model Intercomparison and Improvement Project: Phase I Activities by a Global Community of Science (Invited)

    Science.gov (United States)

    Rosenzweig, C.; Jones, J.; Hatfield, J.; Antle, J. M.; Mutter, C.; Ruane, A. C.

    2013-12-01

    The Agricultural Model Intercomparison and Improvement Project (AgMIP) is a major international effort linking the climate, crop, and economic modeling communities with cutting-edge information technology to produce improved crop and economic models and the next generation of climate impact projections for the agricultural sector. Currently, AgMIP has over 575 participants from more than 45 countries contributing their expertise to over 30 projects and activities. The goals of AgMIP are to improve substantially the characterization of world food security due to climate change and to enhance adaptation capacity in both developing and developed countries. Analyses of the agricultural impacts of climate variability and change require a transdisciplinary effort to consistently link state-of-the-art climate scenarios to crop and economic models with a strong grounding in observations of current agricultural systems around the world. The performance of agricultural models in current climate forms a key basis for our understanding of how crops will respond to future climate changes, and thus AgMIP has a particular focus on extreme heat and drought. Climate, crop model, economics, and information technology protocols are used to guide coordinated AgMIP research activities around the world, along with cross-cutting themes that address aggregation, uncertainty, and the development of Representative Agricultural Pathways (RAPs) to enable testing of climate change adaptations in the context of other global trends. Research activities include ongoing crop-specific assessments (e.g., maize, wheat, sugarcane, rice) and improvement activities, global gridded crop and economic model intercomparisons, and many other initiatives that allow for the better evaluation of the impacts of climate change on agricultural production and food security around the world. AgMIP activities are improving the representation of crop response to changing carbon dioxide, temperature extremes, and water

  2. Global Radiological Source Sorting, Tracking, and Monitoring Project: Phase I Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Randy M [ORNL; Hill, David E [ORNL; Gorman, Bryan L [ORNL

    2010-09-01

    As a proof of concept tested in an operational context, the Global Radiological Source Sorting, Tracking, and Monitoring (GRadSSTraM) Project successfully demonstrated that radio frequency identification (RFID) and Web 2.0* technologies can be deployed to track controlled shipments between the United States and the European Union. Between November 2009 and May 2010, a total of 19 shipments were successfully shipped from Oak Ridge National Laboratory (ORNL) by the U.S. Postal Service (USPS) and tracked to their delivery at England's National Physical Laboratory (NPL) by the United Kingdom Royal Mail. However, the project can only be viewed as a qualified success as notable shortcomings were observed. Although the origin and terminus of all RFID-enabled shipments were recorded and no shipments were lost, not all the waypoints between ORNL and NPL were incorporated into the pilot. Given limited resources, the project team was able to install RFID listeners/actuators at three waypoints between the two endpoints. Although it is likely that all shipments followed the same route between ORNL and NPL, it cannot be determined beyond question that all 19 shipments were routed on identical itineraries past the same three waypoints. The pilot also raises the distinct possibility that unattended RFID tracking alone, without positive confirmation that a tagged item has been properly recorded by an RFID reader, does not meet a rigorous standard for shipping controlled items. Indeed, the proof of concept test strongly suggests that a multifaceted approach to tracking may be called for, including tracking methods that are capable of reading and accepting multiple inputs for individual items [e.g., carrier-provided tracking numbers, Universal Product Codes (UPCs), and RFID tags]. For controlled items, another apparent requirement is a confirmation feature, human or otherwise, which can certify that an item's RFID tag, UPC, or tracking number has been recorded.

  3. Global Radiological Source Sorting, Tracking, and Monitoring Project: Phase I Final Report

    International Nuclear Information System (INIS)

    As a proof of concept tested in an operational context, the Global Radiological Source Sorting, Tracking, and Monitoring (GRadSSTraM) Project successfully demonstrated that radio frequency identification (RFID) and Web 2.0* technologies can be deployed to track controlled shipments between the United States and the European Union. Between November 2009 and May 2010, a total of 19 shipments were successfully shipped from Oak Ridge National Laboratory (ORNL) by the U.S. Postal Service (USPS) and tracked to their delivery at England's National Physical Laboratory (NPL) by the United Kingdom Royal Mail. However, the project can only be viewed as a qualified success as notable shortcomings were observed. Although the origin and terminus of all RFID-enabled shipments were recorded and no shipments were lost, not all the waypoints between ORNL and NPL were incorporated into the pilot. Given limited resources, the project team was able to install RFID listeners/actuators at three waypoints between the two endpoints. Although it is likely that all shipments followed the same route between ORNL and NPL, it cannot be determined beyond question that all 19 shipments were routed on identical itineraries past the same three waypoints. The pilot also raises the distinct possibility that unattended RFID tracking alone, without positive confirmation that a tagged item has been properly recorded by an RFID reader, does not meet a rigorous standard for shipping controlled items. Indeed, the proof of concept test strongly suggests that a multifaceted approach to tracking may be called for, including tracking methods that are capable of reading and accepting multiple inputs for individual items (e.g., carrier-provided tracking numbers, Universal Product Codes (UPCs), and RFID tags). For controlled items, another apparent requirement is a confirmation feature, human or otherwise, which can certify that an item's RFID tag, UPC, or tracking number has been recorded.

  4. Seismic Safety Margins Research Program (Phase I). Project IV. Structural building response; Structural Building Response Review

    Energy Technology Data Exchange (ETDEWEB)

    Healey, J.J.; Wu, S.T.; Murga, M.

    1980-02-01

    As part of the Phase I effort of the Seismic Safety Margins Research Program (SSMRP) being performed by the University of California Lawrence Livermore Laboratory for the US Nuclear Regulatory Commission, the basic objective of Subtask IV.1 (Structural Building Response Review) is to review and summarize current methods and data pertaining to seismic response calculations particularly as they relate to the objectives of the SSMRP. This material forms one component in the development of the overall computational methodology involving state of the art computations including explicit consideration of uncertainty and aimed at ultimately deriving estimates of the probability of radioactive releases due to seismic effects on nuclear power plant facilities.

  5. Seismic Safety Margins Research Program (Phase I). Project IV. Structural building response; Structural Building Response Review

    International Nuclear Information System (INIS)

    As part of the Phase I effort of the Seismic Safety Margins Research Program (SSMRP) being performed by the University of California Lawrence Livermore Laboratory for the US Nuclear Regulatory Commission, the basic objective of Subtask IV.1 (Structural Building Response Review) is to review and summarize current methods and data pertaining to seismic response calculations particularly as they relate to the objectives of the SSMRP. This material forms one component in the development of the overall computational methodology involving state of the art computations including explicit consideration of uncertainty and aimed at ultimately deriving estimates of the probability of radioactive releases due to seismic effects on nuclear power plant facilities

  6. Processing of projections containing phase contrast in laboratory micro-computerized tomography imaging

    OpenAIRE

    Zápražný, Zdenko; Korytár, Dušan; Mikulík, Petr; Áč, Vladimír

    2013-01-01

    Free-space-propagation-based imaging belongs to several techniques for achieving phase contrast in the hard X-ray range. The basic precondition is to use an X-ray beam with a high degree of coherence. Although the best sources of coherent X-rays are synchrotrons, spatially coherent X-rays emitted from a sufficiently small spot of laboratory microfocus or sub-microfocus sources allow the transfer of some of the modern imaging techniques from synchrotrons to laboratories. Spatially coherent X-r...

  7. European research and actual results in the project ''high performance light water reactors phase 2''

    International Nuclear Information System (INIS)

    The high performance light water reactor (HPLWR) is a LWR working with supercritical water as coolant medium and moderator. The operational pressure is 25 MPa and the fresh steam temperatures are above 500 C, resulting in a significantly higher turbine power and an enhanced efficiency It is expected the electricity production cost will be lower than those of conventional LWR. Phase two included a feasibility study of the HPLWR. The work packages are: design and integration, core design, safety, materials, heat transfer, education and dissemination, and management. The authors describe the actual results in the frame of these work packages.

  8. Texas Clean Energy Project: Decision Point Application, Section 2: Topical Report - Phase 1, February 2010-October 2013

    Energy Technology Data Exchange (ETDEWEB)

    Mattes, Karl

    2013-09-01

    Summit Texas Clean Energy, LLC (STCE) is developing the Texas Clean Energy Project (TCEP or the Project) to be located near Penwell, Texas. The TCEP will include an Integrated Gasification Combined Cycle (IGCC) power plant with a nameplate capacity of 400 megawatts electric (MWe), combined with the production of urea fertilizer and the capture, utilization and storage of carbon dioxide (CO2) sold commercially for regional use in enhanced oil recovery (EOR) in the Permian Basin of west Texas. The TCEP will utilize coal gasification technology to convert Powder River Basin subbituminous coal delivered by rail from Wyoming into a synthetic gas (syngas) that will be cleaned and further treated so that at least 90 percent of the overall carbon entering the IGCC facility will be captured. The clean syngas will then be divided into two highhydrogen (H2) concentration streams, one of which will be combusted as a fuel in a combined cycle power block for power generation and the other converted into urea fertilizer for commercial sale. The captured CO2 will be divided into two streams: one will be used in producing the urea fertilizer and the other will be compressed for transport by pipeline for offsite use in EOR and permanent underground sequestration. The TCEP was selected by the U.S. Department of Energy (DOE) Office of Fossil Energy (FE) for cost-shared co-funded financial assistance under Round 3 of its Clean Coal Power Initiative (CCPI). A portion of this financial assistance was budgeted and provided for initial development, permitting and design activities. STCE and the DOE executed a Cooperative Agreement dated January 29, 2010, which defined the objectives of the Project for all phases. During Phase 1, STCE conducted and completed all objectives defined in the initial development, permitting and design portions of the Cooperative Agreement. This topical report summarizes all work associated with the project objectives, and

  9. The International Intraval project. Phase 1 case 6: synthetic migration experiment

    International Nuclear Information System (INIS)

    This case deals with hydraulic and tracer migration tests at a synthetic site. A highly detailed, realistic but synthetic geosphere was developed whose geometry, processes and parameter ranges were conditioned with data from the Grimsel Rock Laboratory. A limited number of 'experiments' on the synthetic geosphere in the form of transient and steady-state pumping tests were conducted by numerical simulation. The project teams were provided with qualitative and quantitative information from the simulated tests, and could request further data. Modelers calibrated their models with the available data, and were then asked to compute breakthrough of conservative tracer between boreholes using their calibrated models. Results were then compared to the 'true' results calculated and supplied by the Pilot Team using the complete synthetic geosphere. The project teams used methods ranging from simple manual adjustment to sophisticated mathematical inverse and geostatistical procedures to estimate the parameters and in some cases predict break through. Result failed to indicate a clear advantage of more complicated methods of analysis over simpler ones. However, several of the teams using more sophisticated methods did not have adequate time to complete their analyses. This exercise demonstrated the great difficulty of predicting site performance on the basis of a small number of tests. 27 refs., 32 figs., 8 tabs

  10. Limitations to the determination of a Laguerre-Gauss spectrum via projective, phase-flattening measurement

    CERN Document Server

    Qassim, Hammam; Torres, Juan P; Padgett, Miles J; Karimi, Ebrahim; Boyd, Robert W

    2014-01-01

    One of the most widely used techniques for measuring the orbital angular momentum components of a light beam is to flatten the spiral phase front of a mode, in order to couple it to a single-mode optical fiber. This method, however, suffers from an efficiency that depends on the orbital angular momentum of the initial mode and on the presence of higher order radial modes. The reason is that once the phase has been flattened, the field retains its ringed intensity pattern and is therefore a nontrivial superposition of purely radial modes, of which only the fundamental one couples to a single mode optical fiber. In this paper, we study the efficiency of this technique both theoretically and experimentally. We find that even for low values of the OAM, a large amount of light can fall outside the fundamental mode of the fiber, and we quantify the losses as functions of the waist of the coupling beam of the orbital angular momentum and radial indices. Our results can be used as a tool to remove the efficiency bias...

  11. Identification of the anti-oxidant components in a two-step solvent extract of bovine bile lipid: Application of reverse phase HPLC, mass spectrometry and fluorimetric assays.

    Science.gov (United States)

    Singh, Namrata; Bhattacharyya, Debasish

    2016-04-15

    An ether extract of nine different bacterial metabolites in combination with two solvent extract (ether followed by ethanol) of bile lipids from ox gall bladder is used as an immune stimulator drug. Over the years bile acids are discussed regarding their anti-oxidant and lipid peroxidation properties. Since some of the bile acids are known to be potent antioxidants, presence of similar activity in the solvent extract of ox bile lipid was investigated using TLC and reverse phase HPLC systems. Fractions from HPLC were analyzed with mass spectrometry using electrospray ionization. The presence of twelve different bile acids along with other substances in small proportions including fatty acids, sulfate conjugates and bile pigments were confirmed. The twelve separated peaks had similar retention times as those of tauroursodeoxycholic acid, glycoursodeoxycholic acid, taurocholic acid, glycocholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, deoxycholic acid, and lithocholic acid. Subsequently, all fractions were tested for their anti-oxidative property on HepG2 cells exposed to H2O2 that served as an oxidative injury model. Four fluorescent dyes H2DCF DA, MitoSOX red, Amplex red and DAF-2 DA were used for estimation of reactive radicals in the HepG2 cells. Among the separated bile acids, tauroursodeoxycholic acid, glycoursodeoxycholic acid and ursodeoxycholic acid prevented the HepG2 cells from H2O2-induced oxidative stress. PMID:26639449

  12. The Urban Environmental Monitoring/100 Cities Project: Legacy of the First Phase and Next Steps

    Science.gov (United States)

    Stefanov, William L.; Wentz, Elizabeth A.; Brazel, Anthony; Netzband, Maik; Moeller, Matthias

    2009-01-01

    The Urban Environmental Monitoring (UEM) project, now known as the 100 Cities Project, at Arizona State University (ASU) is a baseline effort to collect and analyze remotely sensed data for 100 urban centers worldwide. Our overarching goal is to use remote sensing technology to better understand the consequences of rapid urbanization through advanced biophysical measurements, classification methods, and modeling, which can then be used to inform public policy and planning. Urbanization represents one of the most significant alterations that humankind has made to the surface of the earth. In the early 20th century, there were less than 20 cities in the world with populations exceeding 1 million; today, there are more than 400. The consequences of urbanization include the transformation of land surfaces from undisturbed natural environments to land that supports different forms of human activity, including agriculture, residential, commercial, industrial, and infrastructure such as roads and other types of transportation. Each of these land transformations has impacted, to varying degrees, the local climatology, hydrology, geology, and biota that predate human settlement. It is essential that we document, to the best of our ability, the nature of land transformations and the consequences to the existing environment. The focus in the UEM project since its inception has been on rapid urbanization. Rapid urbanization is occurring in hundreds of cities worldwide as population increases and people migrate from rural communities to urban centers in search of employment and a better quality of life. The unintended consequences of rapid urbanization have the potential to cause serious harm to the environment, to human life, and to the resulting built environment because rapid development constrains and rushes decision making. Such rapid decision making can result in poor planning, ineffective policies, and decisions that harm the environment and the quality of human life

  13. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Sudan. February-March 1981

    International Nuclear Information System (INIS)

    The IUREP Orientation Phase Mission to the Democratic Republic of the Sudan believes that the Speculative Resources of the country might fall between 20,000 and 40,000 tonnes uranium and more. This indicates that the Speculative Resources of the Sudan could be significantly higher than previously estimated (7,500 tonnes uranium) by the NEA/IAEA Steering Group on the Uranium Resources - IUREP Phase I. The Government is willing to consider valid exploration programmes presented by prospective partners as long as they serve the interests of both parties. Within the general six-year (1977/78-1982/83) plan for development of the country's mineral resources, the Ministry of Energy and Mining has set up certain priorities which it would like to see expeditiously implemented: uranium exploration and production stands high on the list of priorities. On the basis of very limited information on regional geology and on previous exploration which was available to the Mission, it is estimated that the greatest potential for the Speculative Resources of possible economic significance will prove to occur in the following geological environments of the Sudan (Red Sea Hills area is not included): precambrian basement complex, palaeozoic-mesozoic-tertiary sedimentary basins and the tertiary to recent calcretes. The IUREP Orientation Phase Mission believes that some 20 Million US$ (very rough estimate) will be needed to (1) check the validity of the basic geological concepts formulated on the uranium potential of the selected areas, (2) accumulate diagnostic geological, geophysical, geochemical data indicative of a true uranium potential there, (3) study the basement complex rocks and the sedimentary formations at least on a broad structural-stratigraphic reconnaissance basis (a tremendous amount of valuable water drilling data has accumulated over the last years for some of the selected sedimentary basins) and (4) determine the most appropriate investigation techniques to be utilized

  14. Computational model design specification for Phase 1 of the Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    Napier, B.A.

    1991-07-01

    The objective of the Hanford Environmental Dose Reconstruction (HEDR) Project is to estimate the radiation dose that individuals could have received as a result of emission from nuclear operations at Hanford since their inception in 1944. The purpose of this report is to outline the basic algorithm and necessary computer calculations to be used to calculate radiation doses specific and hypothetical individuals in the vicinity of Hanford. The system design requirements, those things that must be accomplished, are defined. The system design specifications, the techniques by which those requirements are met, are outlined. Included are the basic equations, logic diagrams, and preliminary definition of the nature of each input distribution. 4 refs., 10 figs., 9 tabs.

  15. Analytical quality assurance procedures developed for the IAEA's Reference Asian Man Project (Phase 2)

    International Nuclear Information System (INIS)

    Analytical quality assurance procedures adopted for use in the IAEA Co-ordinated Research Project on Ingestion and Organ Content of Trace Elements of Importance in Radiological Protection are designed to ensure comparability of the analytical results for Cs, I, Sr, Th, U and other elements in human tissues and diets collected and analysed in nine participating countries. The main analytical techniques are NAA and ICP-MS. For sample preparation, all participants are using identical food blenders which have been centrally supplied after testing for contamination. For quality control of the analyses, six NIST SRMs covering a range of matrices with certified and reference values for the elements of interest have been distributed. A new Japanese reference diet material has also been developed. These quality assurance procedures are summarized here and new data are presented for Cs, I, Sr, Th and U in the NIST SRMs. (author)

  16. Computational model design specification for Phase 1 of the Hanford Environmental Dose Reconstruction Project

    International Nuclear Information System (INIS)

    The objective of the Hanford Environmental Dose Reconstruction (HEDR) Project is to estimate the radiation dose that individuals could have received as a result of emission from nuclear operations at Hanford since their inception in 1944. The purpose of this report is to outline the basic algorithm and necessary computer calculations to be used to calculate radiation doses specific and hypothetical individuals in the vicinity of Hanford. The system design requirements, those things that must be accomplished, are defined. The system design specifications, the techniques by which those requirements are met, are outlined. Included are the basic equations, logic diagrams, and preliminary definition of the nature of each input distribution. 4 refs., 10 figs., 9 tabs

  17. River Protection Project Integrated safety management system phase II verification review plan - 7/29/99

    International Nuclear Information System (INIS)

    The purpose of this review is to verify the implementation status of the Integrated Safety Management System (ISMS) for the River Protection Project (RPP) facilities managed by Fluor Daniel Hanford, Inc. (FDH) and operated by Lockheed Martin Hanford Company (LMHC). This review will also ascertain whether within RPP facilities and operations the work planning and execution processes are in place and functioning to effectively protect the health and safety of the workers, public, environment, and federal property over the RPP life cycle. The RPP ISMS should support the Hanford Strategic Plan (DOERL-96-92) to safely clean up and manage the site's legacy waste and deploy science and technology while incorporating the ISMS central theme to ''Do work safely'' and protect human health and the environment

  18. Phase I Water Rental Pilot Project : Snake River Resident Fish and Wildlife Resources and Management Recommendations.

    Energy Technology Data Exchange (ETDEWEB)

    Riggin, Stacey H.; Hansen, H. Jerome

    1992-10-01

    The Idaho Water Rental Pilot Project was implemented as a part of the Non-Treaty Storage Fish and Wildlife Agreement (NTSA) between Bonneville Power Administration and the Columbia Basin Fish and Wildlife Authority. The goal of the project is to improve juvenile and adult salmon and steelhead passage in the lower Snake River with the use of rented water for flow augmentation. The primary purpose of this project is to summarize existing resource information and provide recommendations to protect or enhance resident fish and wildlife resources in Idaho with actions achieving flow augmentation for anadromous fish. Potential impacts of an annual flow augmentation program on Idaho reservoirs and streams are modeled. Potential sources of water for flow augmentation and operational or institutional constraints to the use of that water are identified. This report does not advocate flow augmentation as the preferred long-term recovery action for salmon. The state of Idaho strongly believes that annual drawdown of the four lower Snake reservoirs is critical to the long-term enhancement and recovery of salmon (Andrus 1990). Existing water level management includes balancing the needs of hydropower production, irrigated agriculture, municipalities and industries with fish, wildlife and recreation. Reservoir minimum pool maintenance, water quality and instream flows are issues of public concern that will be directly affected by the timing and quantity of water rental releases for salmon flow augmentation, The potential of renting water from Idaho rental pools for salmon flow augmentation is complicated by institutional impediments, competition from other water users, and dry year shortages. Water rental will contribute to a reduction in carryover storage in a series of dry years when salmon flow augmentation is most critical. Such a reduction in carryover can have negative impacts on reservoir fisheries by eliminating shoreline spawning beds, reducing available fish habitat

  19. ACE project Phases C and D: ACE/MCCI and MACE tests

    International Nuclear Information System (INIS)

    Programs of experiments and related analysis are underway at Argonne National Laboratory investigating the interaction of molten core material with concrete and its coolability. The major objectives are: (1) obtain data on fission product release during molten corium concrete interactions (MCCI); and (2) investigate the conditions for successful cooling and stabilization of core melt attacking the concrete basemat. The fission product release tests have been completed, and data analysis is in progress. The experiments will be analyzed by several groups to validate the various MCCI codes, e.g., CORCON and VANESA, WECHSL and MAAP-DECOMP. A scoping melt attach and coolability experiment (MACE) involving the addition of water atop an on-going MCCI has been performed. A facility to conduct larger scale tests is currently being constructed, and two addition tests are planned to be completed before the end of CY91. This paper describes the progress of the MCCI and the MACE testing programs in the ACE project

  20. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Somalia

    International Nuclear Information System (INIS)

    The IUREP Orientation Phase Mission to Somalia suggests that in addition to the reasonably assured resources (RAR) of 5 000 t uranium and estimated additional resources (EAR) of 11 000 t uranium in calcrete deposits, the speculative resources (SR) could be within the wide range of 0 - 150 000 t uranium. The majority of these speculative resources are related to sandstone and calcrete deposits. The potential for magmatic hydrothermal deposits is relatively small. The Mission recommends an exploration programme of about US $ 22 000 000 to test the uranium potential of the country which is thought to be excellent. The Mission also suggests a reorganization of the Somalia Geological Survey in order to improve its efficiency. Recommended methods include geological mapping, Landsat Imagery Interpretation, airborne and ground scintillometer surveys, and geochemistry. Follow-up radiometric surveys, exploration geophysics, mineralogical studies, trenching and drilling are proposed in favourable areas

  1. International Uranium Resources Evaluation Project (IUREP) orientation phase mission summary report: Thailand

    International Nuclear Information System (INIS)

    The IURBP Orientation Phase Mission assesses the Speculative Uranium Resources in Thailand to be within the range of 1 500 to 38 500 tonnes U. Geological environments which are considered by the Mission to be favourable for uranium occurrences include the following: sandstones of Jurassic to Triassic age; Tertiary sedimentary basins (northern Thailand); Tertiary sedimentary basins (southern Thailand); associated with fluorite deposits; granitic rocks; black shales and graphitic slates of the Palaeozoic; associated with sedimentary phosphate deposits; and associated with monazite sands. Physical conditions in Thailand, including a wet tropical climate, dense forest growth and rugged terrain in some areas and relative inaccessibility, make exploration difficult and costly. There is currently no ready accessibility to detailed topographic and geological maps and other basic data. This lack of availability is a severe constraint to systematic exploration. The lack of skilled personnel experienced in uranium studies and the low level of technical support is a serious hindrance to exploration in Thailand. (author)

  2. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Turkey. September to November 1980

    International Nuclear Information System (INIS)

    The IUREP Orientation Phase Mission to Turkey estimates the Speculative Resources of the country to lie between 21 000 and 55 000 tonnes uranium. Past exploration in Turkey, dating from 1953, has indicated a very high number of uranium occurrences and radioactive anomalies, but ore deposits of significant size and grade have not been found. Present reserves amount to 4 600 tonnes uranium which can be allocated to approximately 15 sandstone type deposits in Neogene continental sediments. Several hundreds of other occurrences and radioactive anomalies exist where ore reserves have not been delineated. The uranium occurrences and radioactive anomalies can be divided according to host rock into (a) crystalline massif and (b) Tertiary continental sediment. The greatest geological potential for further resources is estimated to exist in the above mentioned two geological terrains. The most favourable geological potential exists in Neogene continental sedimentary basins near the crystalline massifs. Because surface exploration in the known favourable areas such as the Koepruebasi Basin has been so systematic, extensive, and successful, it is improbable that additional surface work will have much effect in increasing the number of new radioactive anomalies or uranium occurrences detected at the surface in these areas. Surface survey work in these areas should be mainly designed to assist the understanding of structures at depth. Surface reconnaissance survey work is, however, required in other parts of the above mentioned two geological terrains in this country. Before starting such a reconnaissance survey in new areas, the Mission suggests that a careful and extensive library study be conducted in close co-operation with sedimentologists, petrologists, and remote sensing specialists. The Mission suggests that in the medium term, 8 to 10 years, some 85 - 110 million U.S. Dollars be spent on airborne and ground surveys, including geological, radiometric, geochemical, and

  3. The AquaDEB project: Physiological flexibility of aquatic animals analysed with a generic dynamic energy budget model (phase II)

    Science.gov (United States)

    Alunno-Bruscia, Marianne; van der Veer, Henk W.; Kooijman, Sebastiaan A. L. M.

    2011-11-01

    This second special issue of the Journal of Sea Research on development and applications of Dynamic Energy Budget (DEB) theory concludes the European Research Project AquaDEB (2007-2011). In this introductory paper we summarise the progress made during the running time of this 5 years' project, present context for the papers in this volume and discuss future directions. The main scientific objectives in AquaDEB were (i) to study and compare the sensitivity of aquatic species (mainly molluscs and fish) to environmental variability within the context of DEB theory for metabolic organisation, and (ii) to evaluate the inter-relationships between different biological levels (individual, population, ecosystem) and temporal scales (life cycle, population dynamics, evolution). AquaDEB phase I focussed on quantifying bio-energetic processes of various aquatic species ( e.g. molluscs, fish, crustaceans, algae) and phase II on: (i) comparing of energetic and physiological strategies among species through the DEB parameter values and identifying the factors responsible for any differences in bioenergetics and physiology; (ii) considering different scenarios of environmental disruption (excess of nutrients, diffuse or massive pollution, exploitation by man, climate change) to forecast effects on growth, reproduction and survival of key species; (iii) scaling up the models for a few species from the individual level up to the level of evolutionary processes. Apart from the three special issues in the Journal of Sea Research — including the DEBIB collaboration (see vol. 65 issue 2), a theme issue on DEB theory appeared in the Philosophical Transactions of the Royal Society B (vol 365, 2010); a large number of publications were produced; the third edition of the DEB book appeared (2010); open-source software was substantially expanded (over 1000 functions); a large open-source systematic collection of ecophysiological data and DEB parameters has been set up; and a series of DEB

  4. Combustion of Waste Wood. Second phase of the collaboration project on waste wood combustion

    International Nuclear Information System (INIS)

    Combustion of waste wood has during the last decade increased dramatically and this has resulted in a number of Swedish plants using this fuel, e.g. Handeloe P11 (Norrkoeping) and ldbaecken P3 (Nykoeping), and yet other plants that are under construction (e.g. Nynaeshamn). The experience from these plants are that waste wood combustion results in a number of operational problems. To some extent these problems are different compared with the problems related to combustion of other biofuels but the situation is not directly comparable to waste incinerators. The problems are mainly related to slagging and fouling of heat exchanger surfaces and accelerated corrosion at relatively low temperature compared to the situation for ordinary biofuels. In some cases an increase in the emissions of specific substances can also result in difficulties to fulfil the EC-directive on waste combustion. Within previous projects the main problems related to combustion of waste wood have been identified and to some extent the cause of these problems has been clarified. One result of this reported investigation is a deeper understanding of the actual causes of these problems. However, the most important result is a number of recommendations for different measures on how to achieve disturbance-free combustion of waste wood. These recommendations actually summarises the most important possible solutions on how to achieve a disturbance-free operation and a lower maintenance cost for boilers combusting waste wood and can thereby be regarded as a short summery of the whole project: 1) Improving fuel quality by Improved sorting at the source and Sieving of the fuel -> Reducing the amount of metals and chlorine and Separation of fines and thereby reducing the amount of metals. 2) Combustion modifications by Avoiding reducing conditions at the heat exchanger surfaces -> Minimising slagging, fouling and corrosion. 3) Additives or co-combustion by Addition of sulphur with the fuel; Injection of

  5. Seismic safety margins research program. Phase I final report - Major structure response (Project IV)

    International Nuclear Information System (INIS)

    The primary task of the Major Structure Response Project within the Seismic Safety Margins Research Program (SSMRP) was to develop detailed finite element models of the Zion Nuclear Power Plant's containment building and auxiliary-fuel-turbine (AFT) complex. The resulting models served as input to the seismic methodology analysis chain. The containment shell was modeled as a series of beam elements with the shear and bending characteristics of a circular cylindrical shell. Masses and rotary inertias were lumped at nodal points; thirteen modes were included in the analysis. The internal structure was modeled with three-dimensional finite elements, with masses again lumped at selected nodes; sixty modes were included in the analysis. The model of the AFT complex employed thin plate and shell elements to represent the concrete shear walls and floor diaphragms, and beam and truss elements to model the braced frames. Because of the size and complexity of the model, and the potentially large number of degrees of freedom, masses were lumped at a limited number of node points. These points were selected so as to minimize the effect of the discrete mass distribution on structural response. One hundred and thirteen modes were extracted. A second objective of Project IV was to investigate the effects of uncertainty and variability on structural response. To this end, four side studies were conducted. Three of them, briefly summarized in this volume, addressed themselves respectively to an investigation of sources of random variability in the dynamic response of nuclear power plant structures; formulation of a methodology for modeling and evaluating the effects of structural uncertainty on predicted modal characteristics of major nuclear power plant structures and substructures; and a preliminary evaluation of nonlinear responses in shear-wall structures. A fourth side study, reported in detail in this volume, quantified variations in dynamic characteristics and seismic

  6. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Colombia. February - March 1980

    International Nuclear Information System (INIS)

    The basic objective of IUREP is to 'review the present body of knowledge pertinent to the existence of uranium resources, to review and evaluate the potential for discovery of additional uranium resources, and to suggest new exploration efforts which might be carried out in promising new areas in collaboration with the countries concerned'. Following the initial bibliographic study, which formed Phase I of IUREP, it was envisaged that a further assessment in co-operation with the country in question would lead to a better delineation of areas of high potential and a more reliable estimate as to the degree of favourability for the discovery of additional uranium resources. It was planned that such work would be accomplished through field missions to the country and that these field missions and the resulting report would constitute the IUREP Orientation Phase. The purpose of the Orientation Mission to Colombia was (i) to develop a better understanding of the uranium potential of the country, (ii) to delineate areas favourable for the discovery of speculative uranium resources, (iii) to make recommendations, as appropriate, on the best methods for evaluating the favourable areas, operating procedures and estimated possible costs, (iv) to develop the logistical data required to carry out any possible further work, and (v) to compile a report that would be immediately available to the Colombian authorities. Uranium exploration in Colombia is of very recent date, with the majority of activities getting under way only after 1970. In spite of the limited work that has been done, however, over 1300 radioactive anomalies have been recorded. The total number of uranium mineral occurrences resulting from follow-up work is still very small, and some are unusual in world terms. Topographic and geographic conditions in Colombia make geological and exploration work very difficult and costly, especially in the Cordilleras and the Interior Zone (Llanos Orientales). There are, at

  7. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Thailand. February-March 1981

    International Nuclear Information System (INIS)

    The I.U.R.E.P. Orientation Phase Mission assesses the Speculative Uranium Resources in Thailand to be within the range of 1,500 to 38,500 tonnes U. This range is higher than the previous assessment in Phase I because the Mission recognizes additional favourable geological environments. At the same time, the untested and therefore the unknown degree of mineralization in some of these environments is acknowledged. Past exploration, dating from 1977, has been mainly confined to ground surveys of a small mineralized area and to airborne gamma-ray surveys of two small test areas. Ground reconnaissance work and prospecting has recognized some mineralization in several different host rocks and environments. Geological environments considered by the Mission to be favourable for uranium occurrences include sandstone of Jurassic to Triassic age, tertiary sedimentary basins (northern Thailand), tertiary sedimentary basins (southern Thailand), associated with fluorite deposits, granitic rocks, black shales and graphitic slates of the Paleozoic, associated with sedimentary phosphate deposits and associated with monazite sands. It is recommended that exploration for uranium resources in Thailand should continue. Planners of future exploration programmes should take the following activities into consideration. Rapid extension of carborne surveys to cover, without excessive overburdening, all areas having sufficient road density. Airborne gamma-ray surveys should be carried out in certain selected areas. In the selection of such areas, the considerable higher cost factor attendant on this method of surveying dictates that airborne surveys should only be carried out where carborne surveys prove ineffective (lack of adequate road network.) and where the topography is sufficiently even to assure a low but safe clearance and meaningful results. In certain areas, including the Khorat Plateau and the Tertiary Basins in northern and southern Thailand, there is a need for widely spaced

  8. Dependency Analysis Guidance. Nordic/German Working Group on Common cause Failure analysis. Phase 1 project report: Comparisons and application to test cases

    International Nuclear Information System (INIS)

    This report is part of the reporting from the European Working Group on CCF analysis (EWG), including members from Finland, Germany and Sweden. The project is planned in two phases with a reporting and progress evaluation before initiation of the second phase. Phase 1: Comparisons and application to test cases (2006). Phase 2: Development of harmonized approach and applications (2007). This report summarizes the work during the 1st phase of the project, which included the following main tasks: Task 1: Survey of databases, Task 2: Survey of methods for classification and quantification of CCF-events and description of these methods. Task 3: Classify events for application, using different approaches as recommended above. Task 4: Draw conclusions for harmonization

  9. The Eurosdr Project "RADIOMETRIC Aspects of Digital Photogrammetric IMAGES" - Results of the Empirical Phase

    Science.gov (United States)

    Honkavaara, E.; Arbiol, R.; Markelin, L.; Martínez, L.; Bovet, S.; Bredif, M.; Chandelier, L.; Heikkinen, V.; Korpela, I.; Lelegard, L.; Pérez, F.; Schläpfer, D.; Tokola, T.

    2011-09-01

    This article presents the empirical research carried out in the context of the multi-site EuroSDR project "Radiometric aspects of digital photogrammetric images" and provides highlights of the results. The investigations have considered the vicarious radiometric and spatial resolution validation and calibration of the sensor system, radiometric processing of the image blocks either by performing relative radiometric block equalization or into absolutely reflectance calibrated products, and finally aspects of practical applications on NDVI layer generation and tree species classification. The data sets were provided by Leica Geosystems ADS40 and Intergraph DMC and the participants represented stakeholders in National Mapping Authorities, software development and research. The investigations proved the stability and quality of evaluated imaging systems with respect to radiometry and optical system. The first new-generation methods for reflectance calibration and equalization of photogrammetric image block data provided promising accuracy and were also functional from the productivity and usability points of view. The reflectance calibration methods provided up to 5% accuracy without any ground reference. Application oriented results indicated that automatic interpretation methods will benefit from the optimal use of radiometrically accurate multi-view photogrammetric imagery.

  10. The environmental control and life support system advanced automation project. Phase 1: Application evaluation

    Science.gov (United States)

    Dewberry, Brandon S.

    1990-01-01

    The Environmental Control and Life Support System (ECLSS) is a Freedom Station distributed system with inherent applicability to advanced automation primarily due to the comparatively large reaction times of its subsystem processes. This allows longer contemplation times in which to form a more intelligent control strategy and to detect or prevent faults. The objective of the ECLSS Advanced Automation Project is to reduce the flight and ground manpower needed to support the initial and evolutionary ECLS system. The approach is to search out and make apparent those processes in the baseline system which are in need of more automatic control and fault detection strategies, to influence the ECLSS design by suggesting software hooks and hardware scars which will allow easy adaptation to advanced algorithms, and to develop complex software prototypes which fit into the ECLSS software architecture and will be shown in an ECLSS hardware testbed to increase the autonomy of the system. Covered here are the preliminary investigation and evaluation process, aimed at searching the ECLSS for candidate functions for automation and providing a software hooks and hardware scars analysis. This analysis shows changes needed in the baselined system for easy accommodation of knowledge-based or other complex implementations which, when integrated in flight or ground sustaining engineering architectures, will produce a more autonomous and fault tolerant Environmental Control and Life Support System.

  11. FALSIRE. CSNI project for fracture analyses of large-scale international reference experiments. Phase 1

    International Nuclear Information System (INIS)

    The six experiments used in Project FALSIRE (performed in the Federal Republic of Germany, Japan, the United Kingdom, and the U.S.A.) were designed to examine various aspects of crack growth in reactor pressure vessel (RPV) steels under pressurized-thermal-shock (PTS) loading conditions. The CSNI/FAG established a common format for comprehensive statements of these experiments, including supporting information and available analysis results. For each experiment, analysis results provided estimates of variables such as crack growth, crack-mouth-opening displacement, temperature, stress, strain, and applied J and K values. A comparative assessment and discussion of the analysis results are presented; also, the current status of the entire results data base is summarized. Generally, these results highlight the importance of adequately modeling structural behavior of specimens before performing fracture mechanics evaluations. Applications of the various fracture methodologies were found to be partially successful in some cases but not in others. Based on these assessments, some conclusions concerning predictive capabilities of selected ductile fracture methodologies, as applied to RPVs subjected to PTS loading are given. (orig.)

  12. Project SAFE. Update of the SFR-1 safety assessment. Phase 1. Appendix A2: Scenarios

    International Nuclear Information System (INIS)

    This appendix gives a short description of the scenario methodology adopted in the previous safety assessment of SFR. Since then new methodologies for developing structured descriptions of how processes and interactions between processes affect the evolution of a repository system. Two such methods are briefly described. These methods are very similar, but they differ in the way the system is graphically structured. One of the methods is based on Process Influence Diagrams, PID, and the other on Interaction matrices. It is proposed that the method based on Interaction matrices is used for the scenario work in project SAFE. The main reason for this is that the method already has been applied by SKB, which means that it will be possible to use already existing procedures and documentation systems. The proposed procedure involves the development of Interaction matrices for a defined Reference scenario and the use of these matrices to illustrate the effect of different Scenario initiating FEPs. The proposed procedure is described in this appendix

  13. The International intraval project. Phase 1 case 8: The Alligator rivers natural analogue

    International Nuclear Information System (INIS)

    INTRAVAL is an international coordinated research program for predicting the potential radionuclide migration in the geosphere with the use of mathematical models. Such models are used to help assess the long-term safety of radioactive waste disposal systems. The objective of the Alligator Rivers Analogue Project (ARAP) is to identify and study long-term processes that have been significant in the development of the uranium dispersion zone at the Koongarra uranium ore deposit in the Northern Territory of Australia. This report includes a description of the site geology and gives an outline of the experimental programs, which are aimed to study the hydrogeology and geochemistry of the system, and the distribution of uranium and its daughter radionuclides in the rock strata. The extensive databases that have resulted from these studies have been used to develop and test hydrological, geochemical and transport models. A good basis has been established for modelling the transport of radionuclides in the porous, weathered zone of the Koongarra uranium deposit and its surroundings. A number of preliminary transport, hydrology and geochemical modelling reports are given, with the Koongarra databases also being used to test a Performance Assessment model. The possible application of scenario development procedures to the Koongarra site is discussed. 106 refs., 67 figs., 28 tabs

  14. Waste acid detoxification and reclamation: Phase 1, Project planning and concept development

    International Nuclear Information System (INIS)

    The objectives of this project are to develop processes for reducing the volume, quantity, and toxicity of metal-bearing waste acids. The primary incentives for implemeting these types of waste minimization processes are regulatory and economic in that they meet requirements in the Resource Conservation and Recovery Act and reduce the cost for treatment, storage, and disposal. Two precipitation processes and a distillation process are being developed to minimize waste from fuel fabrication operations, which comprise a series of metal-finishing operations. Waste process acids, such as HF/--/HNO3 etch solutions contianing Zr as a major metal impurity and HNO3 strip solutions containing Cu as a major metal impurity, are detoxified and reclaimed by concurrently precipitating heavy metals and regenerating acid for recycle. Acid from a third waste acid stream generated from chemical milling operations will be reclaimed using distillation. This stream comprises HNO3 and H2SO4 which contains U as the major metal impurity. Distillation allows NO3/sup /minus// to be displaced by SO4/sup /minus/2/ in metal salts; free HNO3 is then vaporized from the U-bearing sulfate stream. Uranium can be recovered from the sulfate stream in downstream precipitation step. These waste minimization processes were developed to meet Hanford's fuel fabrication process needs. 7 refs., 4 figs., 1 tab

  15. Analysis of Early Severe Accident Initiated by LBLOCA for Qinshan Phase II Nuclear Power Project

    Directory of Open Access Journals (Sweden)

    Shi Xing-Wei

    2013-07-01

    Full Text Available The purpose of this study is to simulate an early Severe Accident (SA scenario more detail through transferring the thermal-hydraulic status of the plant predicted by RELAP5 computer code to SA Program (SAP. Based on the criterion of date extract time, the RELAP5 thermal-hydraulic calculation data is extracted to form a file for SAP input card at 1477K of cladding surface. Relying on the thermal-hydraulic boundary parameters calculated by RELAP5 code, analysis of early SA initiated by the Large Break Loss-of-Coolant Accident (LBLOCA without mitigation measures for Qinshan Phase II Nuclear Power Plant (QSP-II performed by SAP through finding the key events of accident sequence, estimating the amount of hydrogen generation and oxidation behavior of the cladding and evaluating the relocation order of the materials collapsed in the central region of the core. The results of this study are expected to improve the SA analysis methodology more detail through analyzing early SA scenario.

  16. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Morocco. Draft

    International Nuclear Information System (INIS)

    The results of the study carried out during the IUREP Orientation Phase in Morocco permit to think that the possible reserves of uranium in this country range between 33,500 t and 89,500 t U3O8 for what concerns the known traces and the already prospected zones in the Northern provinces. If we consider the favourability criteria of certain geological contexts that have not been researched yet in the same provinces and the speculative potential of the Southern provinces that have not been prospected at all, we can reasonably estimate reserves to double. In this case, the potential in uranium for the whole Morocco could range between 70,000 and 180,000 tons. The uranium phosphate constitutes by far the most important reserves of Morocco and the Moroccan government has decided to recuperate this uranium as sub-product from phosphoric acid. The consultants of the IUREP mission have estimated that the 'geological reserves' were ranging at about 12,3 million tons of U3O8 and that the recoverable reserves could be between 7 and 10 million tons of U3O8

  17. Phase II of the multinational project for fracture analysis of large-scale international reference experiments (FALSIRE II)

    International Nuclear Information System (INIS)

    This document describes the organization and plan for Phase II fo the Project for Fracture Analysis of Large-Scale International Reference Experiments (FALSIRE). The experiments employ a variety of test specimens, test materials, and loading conditions. The primary focus of the experiments was on the behaviour of relatively shallow cracks under conditions that relate to pressurized-thermal-shock loading in a reactor perssure vessel (RPV); the effects of biaxial loading and of cladding on cleavage fracture were separate topics of study in two experiments. A summary of each experiment is included in this report. Final versions of the problem statements will form the basis for FALSIRE II in which evaluations of the experiments will be performed by an international group of analysts using a variety of structural and fracture mechanis techniques. 7 refs, 7 figs, 5 tabs

  18. Qinshan phase II extension nuclear power project thermal stratification and fatigue stress analysis for pressurizer surge line

    International Nuclear Information System (INIS)

    Thermal stratification of pressurizer surge line induced by the inside fluid brings on global bending moments, local thermal stresses, unexpected displacements and support loadings of the pipe system. In order to avoid a costly three-dimensional computation, a combined 1D/2D technique has been developed and implemented to analyze the thermal stratification and fatigue stress of pressurize surge line of QINSHAN Phase II Extension Nuclear Power Project in this paper, using the computer codes SYSTUS and ROCOCO. According to the mechanical analysis results of stratification, the maximum stress and cumulative usage factor, the loadings at connections of surge line to main pipe and RCP and the displacements of surge line at supports are obtained. (authors)

  19. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Madagascar. September-October 1981

    International Nuclear Information System (INIS)

    This study, resulting from the IUREP Orientation Mission to Madagascar, includes the reported information on infrastructure, mining regulations and conditions made available to the Mission. Within the structure of the centrally planned economic system, uranium exploration and mining is considered the exclusive activity of OMNIS, an organization founded by the State for that purpose (Office Militaire National pour les Industries Strategiques). Madagascar has a long history of prospection and small-scale exploitation of uranium (thorium and radium). Some of this activity dates back to 1909, culminating in significant production of both uranium and thorium (in excess of 5900 tonnes of uranothorianite) by the CEA and private contractors in the Fort Dauphin area from 1955 to 1968. Past exploration and development work in a number of areas, notably by the CEA, OMNIS and the IAEA/UNDP, is reviewed and the uranium resources and mineral indications reported. The areas rated at present as the more important and which continue to be investigated (by OMNIS, in conjunction with IAEA/UNDP projects) in the order of priority are: the Fort Dauphin area, the Karroo formation and the Neogene lacustrine basin at Antsirabe. The Mission estimates that Madagascar has a moderate potential for undiscovered resources; it is estimated that such speculative resources could lie within the range of 4000 - 38000 tonnes U. In addition there are areas with as yet untested environments and with no known occurrences which may be favourable but which will require prospection. Modifications to existing programmes and new programmes are suggested. Policy alternatives are reviewed

  20. The Waveform Correlation Event Detection System project, Phase II: Testing with the IDC primary network

    Energy Technology Data Exchange (ETDEWEB)

    Young, C.J.; Beiriger, J.I.; Moore, S.G. [and others

    1998-04-01

    Further improvements to the Waveform Correlation Event Detection System (WCEDS) developed by Sandia Laboratory have made it possible to test the system on the accepted Comprehensive Test Ban Treaty (CTBT) seismic monitoring network. For our test interval we selected a 24-hour period from December 1996, and chose to use the Reviewed Event Bulletin (REB) produced by the Prototype International Data Center (PIDC) as ground truth for evaluating the results. The network is heterogeneous, consisting of array and three-component sites, and as a result requires more flexible waveform processing algorithms than were available in the first version of the system. For simplicity and superior performance, we opted to use the spatial coherency algorithm of Wagner and Owens (1996) for both types of sites. Preliminary tests indicated that the existing version of WCEDS, which ignored directional information, could not achieve satisfactory detection or location performance for many of the smaller events in the REB, particularly those in the south Pacific where the network coverage is unusually sparse. To achieve an acceptable level of performance, we made modifications to include directional consistency checks for the correlations, making the regions of high correlation much less ambiguous. These checks require the production of continuous azimuth and slowness streams for each station, which is accomplished by means of FK processing for the arrays and power polarization processing for the three-component sites. In addition, we added the capability to use multiple frequency-banded data streams for each site to increase sensitivity to phases whose frequency content changes as a function of distance.

  1. Improved methods for urinary atrazine mercapturate analysis-Assessment of an enzyme-linked immunosorbent assay (ELISA) and a novel liquid chromatography-mass spectrometry (LC-MS) method utilizing online solid phase extraction (SPE)

    Energy Technology Data Exchange (ETDEWEB)

    Koivunen, Marja E. [Department of Entomology and the UC Davis Cancer Center, University of California, Davis (United States); Dettmer, Katja [Department of Entomology and the UC Davis Cancer Center, University of California, Davis (United States); Vermeulen, Roel [Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD (United States); Bakke, Berit [Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD (United States); National Institute of Occupational Health, Oslo (Norway); Gee, Shirley J. [Department of Entomology and the UC Davis Cancer Center, University of California, Davis (United States); Hammock, Bruce D. [Department of Entomology and the UC Davis Cancer Center, University of California, Davis (United States)]. E-mail: bdhammock@ucdavis.edu

    2006-07-21

    Elimination of interfering substances in urine by solid phase extraction (SPE) prior to analysis resulted in 10-fold improvement in the sensitivity of atrazine mercapturate (AM) enzyme-linked immunosorbent assay (ELISA) compared to previous reports. Of the two tested SPE systems, Oasis[reg] HLB and MCX, the mixed-mode MCX gave good recoveries (82%) of AM in spiked samples measured by ELISA, whereas the reverse-phase HLB phase was not compatible with the immunochemical method. At relatively high concentrations of urinary AM (>20 ng mL{sup -1}), sample dilution was effective enough for the elimination of interfering substances. The new liquid chromatography-mass spectrometry (LC-MS) method developed for AM utilizes online-SPE with Oasis[reg] HLB, column switching and a stable-isotope internal standard. The limit of quantification (0.05 ng mL{sup -1}) indicates improved sensitivity compared with most previously published LC-MS methods for AM. Validation of all three methods, LC-MS, ELISA + SPE and ELISA + dilution with spiked urine samples showed good correlation between the known and measured concentrations with R {sup 2} values of 0.996, 0.957 and 0.961, respectively. When a set (n = 70 plus 12 blind duplicates) of urine samples from farmers exposed to atrazine was analyzed, there was a good agreement (R {sup 2} = 0.917) between the log normalized data obtained by ELISA + SPE and LC-MS. High correlation among the data obtained by the two tested methods and the LC-MS method by the Center of Disease Control and Prevention (CDC), together with low variability among the blind duplicates, suggests that both methods reported here would be suitable for the analysis of urinary AM as a biomarker for human exposure of atrazine.

  2. Improved methods for urinary atrazine mercapturate analysis-Assessment of an enzyme-linked immunosorbent assay (ELISA) and a novel liquid chromatography-mass spectrometry (LC-MS) method utilizing online solid phase extraction (SPE)

    International Nuclear Information System (INIS)

    Elimination of interfering substances in urine by solid phase extraction (SPE) prior to analysis resulted in 10-fold improvement in the sensitivity of atrazine mercapturate (AM) enzyme-linked immunosorbent assay (ELISA) compared to previous reports. Of the two tested SPE systems, Oasis[reg] HLB and MCX, the mixed-mode MCX gave good recoveries (82%) of AM in spiked samples measured by ELISA, whereas the reverse-phase HLB phase was not compatible with the immunochemical method. At relatively high concentrations of urinary AM (>20 ng mL-1), sample dilution was effective enough for the elimination of interfering substances. The new liquid chromatography-mass spectrometry (LC-MS) method developed for AM utilizes online-SPE with Oasis[reg] HLB, column switching and a stable-isotope internal standard. The limit of quantification (0.05 ng mL-1) indicates improved sensitivity compared with most previously published LC-MS methods for AM. Validation of all three methods, LC-MS, ELISA + SPE and ELISA + dilution with spiked urine samples showed good correlation between the known and measured concentrations with R 2 values of 0.996, 0.957 and 0.961, respectively. When a set (n = 70 plus 12 blind duplicates) of urine samples from farmers exposed to atrazine was analyzed, there was a good agreement (R 2 = 0.917) between the log normalized data obtained by ELISA + SPE and LC-MS. High correlation among the data obtained by the two tested methods and the LC-MS method by the Center of Disease Control and Prevention (CDC), together with low variability among the blind duplicates, suggests that both methods reported here would be suitable for the analysis of urinary AM as a biomarker for human exposure of atrazine

  3. Review of alternative residual contamination guides for the 324 Building B-Cell Cleanout Project. Phase 1

    International Nuclear Information System (INIS)

    This report provides a proposed residual contamination guide (RCG) for the 324 Building B-Cell Cleanout Project, Phase 1, at the Hanford Site. The RCG is expressed as a fraction of the amount of highly dispersible radioactive material that would result in offsite doses equal to the Pacific Northwest Laboratory radiological risk guidelines following the worst credible accident scenario for release of the holdup material. The proposed RCG is 10-1 to 10-2 of the PNL radiological risk guidelines. As part of the development of the RCG, a number of factors were considered. These include the need to provide an appropriate level of flexibility for other activities within the 324 Building that could contribute to the facility's overall radiological risk, uncertainties inherent in safety analyses, and the possible contribution of other 300 Area facilities to overall radiological risk. Because of these factors and the nature of the cleanout project, the RCG is expressed as a range rather than a point value. This report also provides guidance on determining conformance to the RCG, including inspection and measurement techniques, quality assurance requirements, and consideration of uncertainty

  4. Horonobe Underground Research Laboratory project. Synthesis of phase 1 investigation 2001-2005, Volume 'geological disposal research'

    International Nuclear Information System (INIS)

    This report summarizes the progress of research and development on geological disposal during the surface-based investigation phase (2001-2005) in the Horonobe Underground Research Laboratory project, of which aims are to apply the design methods of geological disposal and mass transport analysis to actual geological conditions obtained from the project as an example of actual geological environment. For the first aim, the design methods for the geological disposal facility proposed in 'H12 report (the second progress report)' was reviewed and then improved based on the recent knowledge. The applicability of design for engineered barrier system, backfill of disposal tunnel, underground facility was illustrated. For the second aim, the conceptual structure from site investigation and evaluation to mass transport analysis was developed as a work flow at first. Then following this work flow a series of procedures for mass transport analysis was applied to the actual geological conditions to illustrate the practical workability of the work flow and the applicability of this methodology. Consequently, based on the results, future subjects were derived. (author)

  5. Opportunities with the K600 Magnetic Spectrometer During Phase 1 of the iThemba LABS RIB Project

    Science.gov (United States)

    Neveling, R.

    2015-11-01

    Measurements of hadronic scattering and reactions at zero degrees is highly sought after because of its selectivity to excitations with low angular momentum transfer. High energy resolution measurements of this nature can only be performed at a few facilities worldwide, including iThemba LABS. Such measurements present significant experimental challenges due to the small difference in magnetic rigidity between the projectiles and the particles of interest. Hence a substantial amount of time and effort is required to achieve suitably stable and clean beam conditions before any measurement can be attempted. This results in large inefficiencies in beam usage and data collection under the current beam schedule at iThemba LABS, severely limiting the scope of research that can be performed with this facility. However, it is foreseen that during the first phase of the radioactive-ion beam (RIB) project at iThemba LABS a significant amount of beam-time will become available for stable beam nuclear physics research. It is imperative to plan ahead to ensure optimum utilization of beam-time during this period while taking advantage of the existing unique facilities at iThemba LABS. Potential projects that can make use of the zero-degree capabilities of the K600 magnetic spectrometer are discussed.

  6. Phase Velocity Analysis of Projected Wave Motion Along Oblique Radar Beams - A Numerical Study of Type-1 Radar Echoes

    Directory of Open Access Journals (Sweden)

    Chi-Lon Fern

    2013-01-01

    Full Text Available The nonlinear features of type-1 radar echoes were studied by a two-dimensional (2D simulation of saturation the Farley-Buneman (FB wave. The behavior of this FB wave in a plane perpendicular to the _ magnetic field was simulated with a two-fluid code in which electron inertia was discounted while ion inertia was retained. It showed that the appearance of secondary waves propagating vertically and obliquely as the primary horizontal FB wave saturates. The secondary waves originating from nonlinear saturation process will construct the evolution of 2D modes which can be observed by oblique radar beams. We carried out the statistical analysis of projection phase velocities of 2D modes along oblique radar beam at different radar elevation angles. The result revealed that a likely density gradient effect of type-1 radar echoes for the wavelength dependence of phase velocity would appear at a larger radar elevation angle while short wavelength waves would approach isotropic speeds close to ion acoustic speed. This interesting result is primarily attributed to the spectral features of 2D modes.

  7. Detailed accident analysis for the high level waste preparation phase of the commercial nuclear waste vitrification project

    International Nuclear Information System (INIS)

    The environmental consequences and the probability of conceivable accidents occurring during the high level waste preparation (HLWP) phase of the Commercial Nuclear Waste Vitrification Project (CNWVP) were analyzed. The maximum environmental consequences of postulated accidents were calculated to result in low radiation doses: a 50-year dose commitment of 0.3 rem to the whole body for a maximum individual, and of 20 man-rem to the whole body for the surrounding population. This may be compared to Department of Energy (DOE) values, in Manual Chapter Appendix 0524, of 0.5-rem whole-body annual dose commitment to individuals at points of maximum probable exposure in uncontrolled areas. The calculated whole-body relative dose risk to individuals from accidents is low (1.6 x 10-6 rem/yr) as compared to that received from natural background radiation (approximately 1.5 x 10-1 rem/yr) and as compared to levels specified in Nuclear Regulatory Commission (NRC) requirements for routine releases from nuclear power reactors (5.0 x 10-3 rem/yr). Therefore, the design and operation plans for the HLWP phase are judged not to represent an undue environmental risk from accident conditions

  8. Low side lobe pattern synthesis using projection method with genetic algorithm for truncated cone conformal phased arrays

    Institute of Scientific and Technical Information of China (English)

    Guoqi Zeng; Siyin Li; Yan Zhang; Shanwei Lü

    2014-01-01

    A hybrid method for synthesizing antenna’s three di-mensional (3D) pattern is proposed to obtain the low sidelobe feature of truncated cone conformal phased arrays. In this method, the elements of truncated cone conformal phased arrays are pro-jected to the tangent plane in one generatrix of the truncated cone. Then two dimensional (2D) Chebyshev amplitude distribution optimization is respectively used in two mutual vertical directions of the tangent plane. According to the location of the elements, the excitation current amplitude distribution of each element on the conformal structure is derived reversely, then the excitation cur-rent amplitude is further optimized by using the genetic algorithm (GA). A truncated cone problem with 8×8 elements on it, and a 3D pattern desired side lobe level (SLL) up to 35 dB, is studied. By using the hybrid method, the optimal goal is accomplished with acceptable CPU time, which indicates that this hybrid method for the low sidelobe synthesis is feasible.

  9. Evaluation Of THORTM Mineralized Waste Forms For The DOE Advanced Remediation Technologies Phase 2 Project

    International Nuclear Information System (INIS)

    The U.S. Department of Energy's (DOE) Office of River Protection (ORP) is responsible for the retrieval, treatment, immobilization, and disposal of Hanford's tank waste. Currently there are approximately 56 million gallons of highly radioactive mixed wastes awaiting treatment. A key aspect of the River Protection Project (RPP) cleanup mission is to construct and operate the Waste Treatment and Immobilization Plant (WTP). The WTP will separate the tank waste into high-level and low-activity waste (LAW) fractions, both of which will subsequently be vitrified. The projected throughput capacity of the WTP LAW Vitrification Facility is insufficient to complete the RPP mission in the time frame required by the Hanford Federal Facility Agreement and Consent Order, also known as the Tri-Party Agreement (TPA), i.e. December 31, 2047. Therefore, Supplemental Treatment is required both to meet the TPA treatment requirements as well as to more cost effectively complete the tank waste treatment mission. The Supplemental Treatment chosen will immobilize that portion of the retrieved LAW that is not sent to the WTP's LAW Vitrification facility into a solidified waste form. The solidified waste will then be disposed on the Hanford site in the Integrated Disposal Facility (IDF). In addition, the WTP LAW Vitrification facility off-gas condensate known as WTP Secondary Waste (WTP-SW) will be generated and enriched in volatile components such as Cs-137, I-129, Tc-99, Cl, F, and SO4 that volatilize at the vitrification temperature of 1150 C in the absence of a continuous cold cap. The current waste disposal path for the WTP-SW is to recycle it to the supplemental LAW treatment to avoid a large steady state accumulation in the pretreatment-vitrification loop. Fluidized Bed Steam Reforming (FBSR) offers a moderate temperature (700-750 C) continuous method by which LAW and/or WTP-SW wastes can be processed irrespective of whether they contain organics, nitrates, sulfates

  10. EVALUATION OF THOR MINERALIZED WASTE FORMS FOR THE DOE ADVANCED REMEDIATION TECHNOLOGIES PHASE 2 PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, C.; Jantzen, C.

    2012-02-02

    The U.S. Department of Energy's (DOE) Office of River Protection (ORP) is responsible for the retrieval, treatment, immobilization, and disposal of Hanford's tank waste. Currently there are approximately 56 million gallons of highly radioactive mixed wastes awaiting treatment. A key aspect of the River Protection Project (RPP) cleanup mission is to construct and operate the Waste Treatment and Immobilization Plant (WTP). The WTP will separate the tank waste into high-level and low-activity waste (LAW) fractions, both of which will subsequently be vitrified. The projected throughput capacity of the WTP LAW Vitrification Facility is insufficient to complete the RPP mission in the time frame required by the Hanford Federal Facility Agreement and Consent Order, also known as the Tri-Party Agreement (TPA), i.e. December 31, 2047. Therefore, Supplemental Treatment is required both to meet the TPA treatment requirements as well as to more cost effectively complete the tank waste treatment mission. The Supplemental Treatment chosen will immobilize that portion of the retrieved LAW that is not sent to the WTP's LAW Vitrification facility into a solidified waste form. The solidified waste will then be disposed on the Hanford site in the Integrated Disposal Facility (IDF). In addition, the WTP LAW Vitrification facility off-gas condensate known as WTP Secondary Waste (WTP-SW) will be generated and enriched in volatile components such as Cs-137, I-129, Tc-99, Cl, F, and SO{sub 4} that volatilize at the vitrification temperature of 1150 C in the absence of a continuous cold cap. The current waste disposal path for the WTP-SW is to recycle it to the supplemental LAW treatment to avoid a large steady state accumulation in the pretreatment-vitrification loop. Fluidized Bed Steam Reforming (FBSR) offers a moderate temperature (700-750 C) continuous method by which LAW and/or WTP-SW wastes can be processed irrespective of whether they contain organics, nitrates

  11. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Cameroon. Draft

    International Nuclear Information System (INIS)

    The purpose of the International Uranium Resource Evaluation Project (IUREP) missions to host nations is to: Review the present body of knowledge pertinent to the existence of uranium resources, to review and evaluate the potential for the discovery of additional resources, and to suggest new exploration efforts which might be carried out in promising areas in collaboration with the countries concerned. Guidance in the achievement of these goals is provided through a check list of desired relevant information on: general background, the potential role of nuclear energy, and organizations involved, information on the mining industry, technical manpower employed or available, available maps, aerial photographs, and publications, national geological survey and organizations involved in uranium, private organizations involved in uranium exploration and mining, results of previous exploration, known uranium occurrences, plans for further work, legal and administrative requirements for exploration and logistical information on facilities available. The economy of CAMEROON is sound and continues to expand with an annual growth rates of 5-6%. Emphasis is placed on private investment with government participation in major development projects. The overall investment climate is good. Minerals exploration is carried out under nonexclusive Prospecting License and exclusive Exploration License that may later be converted to a Mining Lease or Mining Concession. Many of the conditions must be negotiated. Uranium is classified as a strategic mineral, and may be subject to special review. There is no defined policy on uranium development. Two government organizations are concerned with geology and mining. The INSTITUT DE RECHERCHES GEOLOGIQUES ET MINIERES (IRGM) conducts programs of geologic mapping and research, mineralogy, hydrology, and alternate energy sources. The DEPARTMENT OF MINES AND GEOLOGY (DMG) is responsible for all minerals exploration and mining. It includes a

  12. Preliminary Public Design Report for the Texas Clean Energy Project: Topical Report - Phase 1, June 2010-July 2011

    Energy Technology Data Exchange (ETDEWEB)

    Mattes, Karl

    2012-02-01

    Summit Texas Clean Energy, LLC (Summit) is developing the Texas Clean Energy Project (TCEP or the project) to be located near Penwell, Texas. The TCEP will include an Integrated Gasification Combined Cycle (IGCC) plant with a nameplate capacity of 400 megawatts electric (MWe), combined with the production of urea fertilizer and the capture, utilization and storage of carbon dioxide (CO2) sold commercially for regional use in enhanced oil recovery (EOR) in the Permian Basin of west Texas. The TCEP will utilize coal gasification technology to convert Powder River Basin sub-bituminous coal delivered by rail from Wyoming into a synthetic gas (syngas) which will be cleaned and further treated so that at least 90 percent of the overall carbon entering the facility will be captured. The clean syngas will then be divided into two high-hydrogen (H2) concentration streams, one of which will be combusted as a fuel in a combined cycle power block for power generation and the other converted into urea fertilizer for commercial sale. The captured CO2 will be divided into two streams: one will be used in producing the urea fertilizer and the other will be compressed for transport by pipeline for offsite use in EOR. The TCEP was selected by the U.S. Department of Energy (DOE) Office of Fossil Energy (FE) for cost-shared co-funded financial assistance under Round 3 of its Clean Coal Power Initiative (CCPI). A portion of this financial assistance was budgeted and provided for initial development, permitting and design activities. Front-end Engineering and Design (FEED) commenced in June 2010 and was completed in July 2011, setting the design basis for entering into the detailed engineering phase of the project. During Phase 1, TCEP conducted and completed the FEED, applied for and received its air construction permit, provided engineering and other technical information required for development of the draft Environmental Impact Statement, and

  13. Quality assurance plan for the Molten Salt Reactor Experiment Remediation Project at the Oak Ridge National Laboratory. Phase 1 -- Interim corrective measures and Phase 2 -- Purge and trap reactive gases

    International Nuclear Information System (INIS)

    This Quality Assurance Plan (QAP) identifies and describes the systems utilized by the Molten Salt Reactor Experiment Remediation Project (MSRERP) personnel to implement the requirements and associated applicable guidance contained in the Quality Program Description Y/QD-15 Rev. 2 (Energy Systems 1995f). This QAP defines the quality assurance (QA) requirements applicable to all activities and operations in and directly pertinent to the MSRERP Phase 1--Interim Corrective Measures and Phase 2--Purge and Trap objectives. This QAP will be reviewed, revised, and approved as necessary for Phase 3 and Phase 4 activities. This QAP identifies and describes the QA activities and procedures implemented by the various Oak Ridge National Laboratory support organizations and personnel to provide confidence that these activities meet the requirements of this project. Specific support organization (Division) quality requirements, including the degree of implementation of each, are contained in the appendixes of this plan

  14. Observation Targeting for the Tehachapi Pass and Mid-Columbia Basin: WindSENSE Phase III Project Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Hanley, D

    2011-10-22

    The overall goal of this multi-phased research project known as WindSENSE is to develop an observation system deployment strategy that would improve wind power generation forecasts. The objective of the deployment strategy is to produce the maximum benefit for 1- to 6-hour ahead forecasts of wind speed at hub-height ({approx}80 m). In Phase III of the project, the focus was on the Mid-Columbia Basin region which encompasses the Bonneville Power Administration (BPA) wind generation area shown in Figure 1 that includes Klondike, Stateline, and Hopkins Ridge wind plants. The typical hub height of a wind turbine is approximately 80-m above ground level (AGL). So it would seem that building meteorological towers in the region upwind of a wind generation facility would provide data necessary to improve the short-term forecasts for the 80-m AGL wind speed. However, this additional meteorological information typically does not significantly improve the accuracy of the 0- to 6-hour ahead wind power forecasts because processes controlling wind variability change from day-to-day and, at times, from hour-to-hour. It is also important to note that some processes causing significant changes in wind power production function principally in the vertical direction. These processes will not be detected by meteorological towers at off-site locations. For these reasons, it is quite challenging to determine the best type of sensors and deployment locations. To address the measurement deployment problem, Ensemble Sensitivity Analysis (ESA) was applied in the Phase I portion of the WindSENSE project. The ESA approach was initially designed to produce spatial fields that depict the sensitivity of a forecast metric to a set of prior state variables selected by the user. The best combination of variables and locations to improve the forecast was determined using the Multiple Observation Optimization Algorithm (MOOA) developed in Phase I. In Zack et al. (2010a), the ESA-MOOA approach was

  15. International Uranium Resources Evaluation Project (IUREP) orientation phase mission report: Venezuela. Draft

    International Nuclear Information System (INIS)

    The IUREP Orientation Phase Mission to Venezuela believes that the Speculative Uranium Resources of that country fall between 2,000 and 42,000 tonnes. This assumes that a part of the Speculative Resources would be extracted as by-product uranium from wet-process phosphoric acid production. Past exploration in Venezuela has resulted in the discovery of very few uranium occurrences and radioactive anomalies except for the many airborne anomalies recorded on the Guayana Shield. To date no economic deposits or significant uranium occurrences have been found in Venezuela except for the uraniferous phosphorites in the Cretaceous Navey Formation which are very low grade. The uranium occurrences and radioactive anomalies can be divided according to host rock into: (1) Precambrian crystalline and sedimentary rocks, (2) Cretaceous phosphorite beds, (3) continental sandstone, and (4) granitic rocks. The greatest geological potential for further uranium resources is believed to exist in the crystalline and sedimentary Precambrian rocks of the Guayana Shield, but favorable geological potential also exist in younger continental sandstones. Since the Guayana Shield is the most promising for the discovery of economic uranium deposits most of the proposed exploration effort is directed toward that area. Considerable time, effort and capital will be required however, because of the severe logistical problems of exploration in this vast, rugged and inaccessable area, Meager exploration work done to date has been relatively negative suggesting the area is more of a thorium rather than a uranium province. However because of the possibility of several types of uranium deposits and because so little exploration work has been done, the Mission assigned a relatively small speculative potential to the area, i.e. 0 to 25,000 tonnes uranium. A small speculative potential (0 to 2,000 tonnes) was assigned to the El Baul area in Cojedes State, in the Llanos Province. This potential is postulated

  16. Characterization of a backfill candidate material, IBECO-RWC-BF Baclo Project - Phase 3 Laboratory tests

    International Nuclear Information System (INIS)

    A backfill candidate material, IBECO-RWC-BF, which origin from Milos, Greece, has been investigated. The material was delivered both as granules and as pellets. The investigation described in this report aimed to characterize the material and evaluate if it can be used in a future repository. The following investigations have been done and are presented in this report: 1. Standard laboratory tests. Water content, liquid limit and swelling potential are examples on standard tests that have been performed. 2. Block manufacturing. The block compaction properties of the material have been determined. A first test was performed in laboratory but also tests in large scale have been performed. After finishing the test phase, 60 tons of blocks were manufactured at Hoeganaes Bjuf AB. The blocks will be used in large scale laboratory tests at Aespoe HRL. 3. Mechanical parameters. The compressibility of the material was investigated with oedometer tests (four tests) where the load was applied in steps after saturation. The evaluated oedometer modulus varied between 34.50 MPa. Tests were made to evaluate the elastic parameters of the material (E, ν). Altogether three tests were made on specimens with dry densities of about 1,710 kg/m3. The evaluated E-modulus and Poisson's ratio varied between 231-263 MPa and 0.16-0.19 respectively. The strength of the material, both the compressive strength and the tensile strength were measured on specimens compacted to different dry densities. The test results yielded a relation between density and the two types of strength. Furthermore, tests have been made in order to determine the compressibility of the unsaturated filling of pellets. Two tests were made where the pellets were loosely filled in a Proctor cylinder and then compressed at a constant rate of strain during continuously measurement of the applied load. 4. Swelling pressure and hydraulic conductivity. There is, as expected, a very clear influence of the dry density on the

  17. NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 5: Aerospace librarians and technical information specialists as information intermediaries: A report of phase 2 activities of the NASA/DOD Aerospace Knowledge Diffusion Research Project

    Science.gov (United States)

    Pinelli, Thomas E.; Kennedy, John M.

    1990-01-01

    The objective of the NASA/DOD Aerospace Knowledge Diffusion Research Project is to provide descriptive and analytical data regarding the flow of scientific and technical information (STI) at the individual, organizational, national, and international levels, placing emphasis on the systems used to diffuse the results of federally funded aerospace STI. An overview of project assumptions, objectives, and design is presented and preliminary results of the phase 2 aerospace library survey are summarized. Phase 2 addressed aerospace knowledge transfer and use within the larger social system and focused on the flow of aerospace STI in government and industry and the role of the information intermediary in knowledge transfer.

  18. High-solids black liquor firing in pulp and paper industry kraft recovery boilers: Phase 1 -- Final report. Volume 2: Project technical results

    Energy Technology Data Exchange (ETDEWEB)

    Southards, W.T.; Clement, J.L.; McIlroy, R.A.; Tharp, M.R.; Verrill, C.L.; Wessell, R.A.

    1995-11-01

    This project is a multiple-phase effort to develop technologies to improve high-solids black liquor firing in pulp mill recovery boilers. The principal means to this end is to construct and operate a pilot-scale recovery furnace simulator (RFS) in which these technologies can be tested. The Phase 1 objectives are to prepare a preliminary design for the RFS, delineate a project concept for evaluating candidate technologies, establish industrial partners, and report the results. Phase 1 addressed the objectives with seven tasks: Develop a preliminary design of the RFS; estimate the detailed design and construction costs of the RFS and the balance of the project; identify interested parties in the paper industry and key suppliers; plan the Phase 2 and Phase 3 tests to characterize the RFS; evaluate the economic justification for high-solids firing deployment in the industry; evaluate high-solids black liquor property data to support the RFS design; manage the project and reporting results, which included planning the future program direction.

  19. Historic land use dynamics in and around Natura2000 sites as indicators for impact on biodiversity; Phase 1 of the BIOPRESS project for the Netherlands

    OpenAIRE

    Hazeu, G.W.; Mücher, C.A.

    2005-01-01

    BIOPRESS is a EC-FP5 research project to support GMES `Global Monitoring for Environment and Security¿. It aims to provide the EU-user community with quantitative information on how changes in land cover and land use have affected the environment and biodiversity in Europe. This report is dealing with the results of the first phase of the BIOPRESS project for the Netherlands. The report concentrates on the selection, acquisition, processing and interpretation of recent and historical aerial p...

  20. Long-term operation of a double phase LAr LEM Time Projection Chamber with a simplified anode and extraction-grid design

    OpenAIRE

    CANTINI, C.; Epprecht, L; Gendotti, A.; Horikawa, S.; Murphy, S.; Natterer, G.; L. Periale; Resnati, F.; Rubbia, A.; Sergiampietri, F.; T. Viant; Wu, S.

    2013-01-01

    We report on the successful operation of a double phase Liquid Argon Large Electron Multiplier Time Projection Chamber (LAr LEM-TPC) equipped with two dimensional projective anodes with dimensions 10$\\times$10 cm$^2$, and with a maximum drift length of 21 cm. The anodes were manufactured for the first time from a single multilayer printed circuit board (PCB). Various layouts of the readout views have been tested and optimised. In addition, the ionisation charge was efficiently extracted from ...

  1. NERI Project 99-119. A New Paradigm for Automatic Development of Highly Reliable Control Architectures for Nuclear Power Plants. Phase-2 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    March-Leuba, JA

    2002-01-15

    This report describes the tasks performed and the progress made during Phase 2 of the DOE-NERI project number 99-119 entitled Automatic Development of Highly Reliable Control Architecture for Future Nuclear Power Plants. This project is a collaboration effort between the Oak Ridge National Laboratory (ORNL), The University of Tennessee, Knoxville (UTK) and the North Carolina State University (NCSU). ORNL is the lead organization and is responsible for the coordination and integration of all work.

  2. Two-tiered keratinocyte assay: IL-18 production by NCTC2544 cells to determine the skin sensitizing capacity and an epidermal equivalent assay to determine sensitizer potency

    DEFF Research Database (Denmark)

    Teunis, Marc; Corsini, Emanuela; Smits, Mieke;

    2012-01-01

    the use of animals. The aim of the EU FP6 Integrated Project Sens-it-iv was to develop and optimize an integrated testing strategy consisting of in vitro, human cell based assays which will closely mimic sensitization mechanisms in vivo. These assays should be an alternative approach to the LLNA. The...... alternative method to the LLNA. Both assays are based on the use of human keratinocytes, which have been shown, over the last two decades, to play a key role in all phases of skin sensitization. First, 4 known chemicals were tested during a transferability study in which 6 laboratories participated. Three......At present, the identification of potentially sensitizing chemicals is carried out using animal models. However, it should be very important, both from ethical and economic point of view, to discriminate allergy and irritation events, and to classify sensitizers according to their potency, without...

  3. Development and validation of a UHPLC-MS/MS assay for colistin methanesulphonate (CMS) and colistin in human plasma and urine using weak-cation exchange solid-phase extraction.

    Science.gov (United States)

    Zhao, Miao; Wu, Xiao-Jie; Fan, Ya-Xin; Guo, Bei-Ning; Zhang, Jing

    2016-05-30

    A rapid ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay method was developed for determination of CMS and formed colistin in human plasma and urine. After extraction on a 96-well SPE Supra-Clean Weak Cation Exchange (WCX) plate, the eluents were mixed and injected into the UHPLC-MS/MS system directly. A Phonomenex Kinetex XB-C18 analytical column was employed with a mobile phase consisting of solution "A" (acetonitrile:methanol, 1:1, v/v) and solution "B" (0.1% formic acid in water, v/v). The flow rate was 0.4mL/min with gradient elution over 3.5min. Ions were detected in ESI positive ion mode and the precursor-product ion pairs were m/z 390.7/101.3 for colistin A, m/z 386.0/101.2 for colistin B, and m/z 402.3/101.2 for polymyxin B1 (IS), respectively. The lower limit of quantification (LLOQ) was 0.0130 and 0.0251mg/L for colistin A and colistin B in both plasma and urine with accuracy (relative error, %)colistin, which offers a highly efficient tool for the analysis of a large number of clinical samples as well as routine therapeutic drug monitoring. PMID:26970986

  4. Assessing sediment contamination using six toxicity assays

    Directory of Open Access Journals (Sweden)

    Allen G. BURTON Jr.

    2001-08-01

    Full Text Available An evaluation of sediment toxicity at Lake Orta, Italy was conducted to compare a toxicity test battery of 6 assays and to evaluate the extent of sediment contamination at various sediment depths. Lake Orta received excessive loadings of copper and ammonia during the 1900’s until a large remediation effort was conducted in 1989-90 using lime addition. Since that time, the lake has shown signs of a steady recovery of biological communities. The study results showed acute toxicity still exists in sediments at a depth of 5 cm and greater. Assays that detected the highest levels of toxicity were two whole sediment exposures (7 d using Hyalella azteca and Ceriodaphnia dubia. The MicrotoxR assay using pore water was the third most sensitive assay. The Thamnotox, Rototox, Microtox solid phase, and Seed Germination-Root Elongation (pore and solid phase assays showed occasional to no toxicity. Based on similarity of responses and assay sensitivity, the two most useful assays were the C. dubia (or H. azteca and Microtox pore water. These assays were effective at describing sediment toxicity in a weight-of-evidence approach.

  5. Ten Perspectives on Nordic Energy. Final report for the first phase of the Nordic Energy Perspectives project

    International Nuclear Information System (INIS)

    Nordic Energy Perspectives is an interdisciplinary energy research project which, from a holistic perspective, analyses and creates new insights into the consequences for energy markets and energy systems of the goals and instruments of energy policy in the light of new conditions. The project's aim is to provide better bases for decisions on energy and environmental policy at both national and international levels. It is intended to contribute to constructive dialogue between researchers, politicians, authorities and actors on the energy markets. A first phase of the project has been carried out during Apr 2005 - Sep 2006. This report summarises the most important results. Around fifteen current research issues have been analysed. Some of these issues have been analysed in detail, while others have been studied more generally. This means that we can present a comprehensive flora of results in a number of areas, whereas in regard to other questions the analysis is less deep and the conclusions are not as firmly grounded. We have nonetheless chosen to present the entire range of results in this final report. An objective of Nordic Energy Perspectives has been to create a forum for fact-based discussion and dialogue between decision-makers and other energy actors from different disciplines and different countries. Today this forum is fully active. We are very eager that the forum should survive and that the discussion should continue concerning the themes treated by Nordic Energy Perspectives. Hence, for each of the chapters 1-17 below, we identify the researchers whom the reader can contact for further dialogue. The ten perspectives, which are based on contributions from the whole research group, have the following headlines: Costly early learnings from the first year of EU ETS: Unforeseen price levels hit industries hard; Market based support schemes - do they really work as intended; New decade in the Nordic energy markets; Reduced CO2 emissions and more

  6. Horonobe Underground Research Laboratory project synthesis of phase I investigation 2001-2005. Volume 'Geological disposal research'

    International Nuclear Information System (INIS)

    This report summarizes the progress of research and development on geological disposal during the surface-based investigation phase (2001-2005) in the Horonobe Underground Research Laboratory project (HOR), of which aims are to apply the design methods of geological disposal and mass transport analysis to actual geological conditions obtained from the surface-based investigations in HOR as an example of actual geological environment. For the first aim, the design methods for the geological disposal facility proposed in 'H12 report (the second progress report)' was reviewed and then improved based on the recent knowledge. The applicability of design for engineered barrier system, backfill of disposal tunnel, underground facility was illustrated. For the second aim, the conceptual structure from site investigation and evaluation to mass transport analysis was developed as a work flow at first. Then following this work flow a series of procedures for mass transport analysis was applied to the actual geological conditions to illustrate the practical workability of the work flow and the applicability of this methodology. Consequently, based on the results, future subjects were derived. (author)

  7. The final collimator has been installed ready for the LHC restart (phase 1 of the LHC collimator project)

    CERN Multimedia

    CERN audiovisual service

    2009-01-01

    The collimators are installed around the LHC ring and the transfer lines to absorb ‘stray’ particles that have spread out, forming a halo around the beam. It is important to absorb this halo to protect the rest of the machine from damage, in particular the superconducting magnets, where any slight heating by the ‘stray particles’ could cause a magnet quench. The one-meter long collimators absorb the particles in the halo by closing a set of ‘jaws’ of various materials around the beam; the most robust collimators use fiber-reinforced graphite. Before the start-up last year, 88 collimators were installed. The unforeseen shutdown caused by the incident in Sector 3-4, allowed the collimator team to continue with the final 20 collimators necessary to maximize the LHC intensity and luminosity reach with the phase 1 collimation system. This marks the end of 6.5 years of hard work since the project began

  8. Community and team member factors that influence the operations phase of local prevention teams: the PROSPER Project.

    Science.gov (United States)

    Feinberg, Mark E; Chilenski, Sarah M; Greenberg, Mark T; Spoth, Richard L; Redmond, Cleve

    2007-09-01

    This study examined the longitudinal predictors of quality of functioning of community prevention teams during the "operations" phase of team development. The 14 community teams were involved in a randomized-trial of a university-community partnership project, PROSPER (Spoth et al., Prevention Science, 5(1): 31-39, 2004b), that implements evidence-based interventions intended to support positive youth development and reduce early substance use, as well as other problem behaviors. The study included a multi-informant approach to measurement of constructs, and included data from 137 team members, 59 human service agency directors and school administrators, 16 school principals, and 8 Prevention Coordinators (i.e. technical assistance providers). We examined how community demographics and social capital, team level characteristics, and team member attributes and attitudes are related to local team functioning across an 18-month period. Findings indicate that community demographics (poverty), social capital, team member attitudes towards prevention, and team members' views of the acceptability of teen alcohol use played a substantial role in predicting various indicators of the quality of team functioning 18 months later. PMID:17602297

  9. Microbead agglutination based assays

    KAUST Repository

    Kodzius, Rimantas

    2013-01-21

    We report a simple and rapid room temperature assay for point-of-care (POC) testing that is based on specific agglutination. Agglutination tests are based on aggregation of microbeads in the presence of a specific analyte thus enabling the macroscopic observation. Such tests are most often used to explore antibody-antigen reactions. Agglutination has been used for protein assays using a biotin/streptavidin system as well as a hybridization based assay. The agglutination systems are prone to selftermination of the linking analyte, prone to active site saturation and loss of agglomeration at high analyte concentrations. We investigated the molecular target/ligand interaction, explaining the common agglutination problems related to analyte self-termination, linkage of the analyte to the same bead instead of different microbeads. We classified the agglutination process into three kinds of assays: a two- component assay, a three-component assay and a stepped three- component assay. Although we compared these three kinds of assays for recognizing DNA and protein molecules, the assay can be used for virtually any molecule, including ions and metabolites. In total, the optimized assay permits detecting analytes with high sensitivity in a short time, 5 min, at room temperature. Such a system is appropriate for POC testing.

  10. Young drivers experience: the results of a second phase training on higher order skills : evaluation study in the framework of the European project NovEV.

    NARCIS (Netherlands)

    Craen, S. de Vissers, J.A.M.M. Houtenbos, M. & Twisk, D.A.M.

    2005-01-01

    To diminish the high accident risk of young drivers, new methods for accident prevention are being investigated. This study in the framework of the European project NovEV evaluates the effects of a post-license training on higher order skills. This second phase driver training consisted of an on-roa

  11. Evaluation of Project P.A.T.H.S. (Secondary 1 Program) by the Program Participants: Findings Based on the Full Implementation Phase

    Science.gov (United States)

    Shek, Daniel T. L.; Sun, Rachel C. F.

    2008-01-01

    A total of 207 schools (N = 33,693 students) participated in the Secondary 1 Program of Project P.A.T.H.S. in the Full Implementation Phase (2006-07). Participants responded to a Subjective Outcome Evaluation Form (Form A) to assess their views of the program, instructors, and perceived effectiveness after program completion. Utilizing the…

  12. 建设工程施工阶段项目管理研究%Construction Project Management of Construction Phase

    Institute of Scientific and Technical Information of China (English)

    黄新哲

    2011-01-01

    在工程项目建设过程中,施工阶段的项目管理至关重要,对工程各个方面的质量有着直接的影响,其重要地位不可估量,所以非常值得我们去思考和探究.本文就建设工程施工阶段项目管理进行了详细的阐述,以供读者参考.%In the project construction process, project management of construction phase is essential to quality of construction, it is worth to think and explore. This paper describes the construction project management of construction phase for reference.

  13. Radioreceptor opioid assay

    International Nuclear Information System (INIS)

    A radioreceptor assay is described for assaying opioid drugs in biological fluids. The method enables the assay of total opioid activity, being specific for opioids as a class but lacking specificity within the class. A radio-iodinated opioid and the liquid test sample are incubated with an opiate receptor material. The percentage inhibition of the binding of the radio-iodinated compound to the opiate receptor is calculated and the opioid activity of the test liquid determined from a standard curve. Examples of preparing radio-iodinated opioids and assaying opioid activity are given. A test kit for the assay is described. Compared to other methods, this assay is cheap, easy and rapid. (U.K.)

  14. Sustainable development in city districts: BaLaLuZ project - Bellevaux; Quartier de Bellevaux - Lausanne. Rapport final de la phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Gay, J.-B.; Montavon, M. [Swiss Federal Institute of Technology (EPFL), Laboratoire d' Energie solaire et de physique du batiment (LESO-PB), Lausanne (Switzerland); Muehll, D. von der [Swiss Federal Institute of Technology (EPFL), Laboratoire de Dynamiques territoriales (LADYT), Lausanne (Switzerland); Malatesta, D. [Ecole d' Etudes sociales et pedagogiques (EESP), Lausanne (Switzerland); Cunha, A. da; Dind, J.-P. [University of Lausanne, Institut de Geographie (UNIL-IGUL), Lausanne (Switzerland)

    2004-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) is one of a series of reports concerning municipal development in various cities in Switzerland. The four city districts involved include Basel (Gundeldinger Feld), Lausanne (Bellevaux), Lucerne (Basel-/Bernstrasse) and Zurich (Werdwies). This final report summarises the results of the first phase of the project in the Bellevaux district of Lausanne. The work done in the first phase is reviewed: A database with details on 240 buildings was set up, a pilot analysis of a building was carried out and suggestions for renovation work were made. Also, a socio-economic analysis of the district was made and the expectations of inhabitants were noted. Mobility was critically analysed and first possibilities in the urban planning area were looked at. Recommendations for the second phase of the project are presented.

  15. Absolute nuclear material assay

    Science.gov (United States)

    Prasad, Manoj K.; Snyderman, Neal J.; Rowland, Mark S.

    2010-07-13

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  16. Absolute nuclear material assay

    Science.gov (United States)

    Prasad, Manoj K.; Snyderman, Neal J.; Rowland, Mark S.

    2012-05-15

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  17. Tricyclic antidepressant radioreceptor assay

    International Nuclear Information System (INIS)

    A receptor assay for tricyclic antidepressants described here is based on the ability of these drugs to compete with [3H]-3-guinuclidnyl benzilate (3H-QNB) for binding to muscarinic cholinergic receptors in rat brain membranes. The assay is sensitive, in that it can detect, for example, 2ng/ml nortriptyline in plasma. Seven plasma samples from depressed patients treated with nortriptyline were assayed with the radioreceptor and gas liquid chromatographic methods, and the results from these two methods were almost identical. This assay should be used cautiously, if at all, in patients treated with other drugs that have potent anticholinergic effects. (Auth.)

  18. An inventory of innovative policies and measures for energy efficiency. Phase 1 of the EU SAVE 'White and Green' project

    International Nuclear Information System (INIS)

    be considered and also modern regulatory approaches. Much attention is paid in this report to the modern market instruments, which are based on the concept of trading, with the most prominent representative being the European Emissions Trading scheme. Other more recent market based instruments discussed in this report are the White and Green Certificates. Encompassing the above, this report intends to provide an overview of all major P+M for energy efficiency improvement. The P+M are categorized according to some parameters such as a general description of the measure, the sector applied, the mechanism at work, the countries where this measure has been designed and/or implemented and the stakeholders they involve during their implementation. Furthermore, a critical assessment of each measure follows according to some criteria, like effectiveness, efficiency and goal achievement. The underlying motivation for the preparation of such an inventory of P+M is to establish the grounds for a comparative assessment of measures as they are currently discussed and/or applied in the European Union. Four P+M will then be chosen which will be then analyzed in depth in Phase II of the 'White and Green' project. In this phase simulation models will be used to study the impact of various solutions on the cost of saving energy (particularly electricity and gas), the role that different technologies could play and their expected diffusion, etc. In the context outlined above, it is clearly of interest to assess the various solutions for market-oriented policy measures aimed at increasing the efficiency in the final uses of energy, to identify the best practices and to present, to the European Commission and to the Member states, indications on the potential advantages of using such practices in the promotion of a common energy policy objective

  19. The Role and Function of Effective Communication in the Planning-Phase of Multi-Organizational International Projects

    OpenAIRE

    Zakaria, Mohamad

    2007-01-01

    This thesis aims at tackling an important issue in the communication management of multi-organizational international projects. Furthermore, it focuses on the importance of effective communication in the planning stage of this kind of projects. The literature review shows the importance of effective communication among the different stakeholders at this stage of the project planning in the life cycle of such projects in particular. The empirical data received through interviews of three proje...

  20. Possible utilization of BIM in the production phase of construction projects : BIM in work preparations at Skanska Sweden AB

    OpenAIRE

    Kojadinovic, Ivica; Björk Löf, Marcus

    2012-01-01

    Construction organizations have had to increase their productivity and make the project process, from conceptual design to handing over, more efficient in order to increase their profit margins. The Information Technology (IT) industry has developed new Information and Communication Technology (ICT) solutions and tools which aim to support construction organizations in projects in order for them to achieve their goals of reduced project costs, increased project control and increased productiv...

  1. The International intraval project. Phase 1, test case 13: Experimental study of brine transport in porous media

    International Nuclear Information System (INIS)

    INTRAVAL is an international coordinated research program for predicting the potential radionuclide migration in the geosphere with the use of mathematical models. Such models are used to help assess the long-term safety of radioactive waste disposal systems. This report describes the findings of the project teams involved in test case 13 of INTRAVAL Phase 1. The test case is based on laboratory experiments dealing with flow and dispersion of brine in a porous medium. The purpose of these experiments was twofold : (i) to investigate some of the relevant processes in brine transport in porous media, and (ii) to provide sets of data to be used for (partial) validation of transport models. The experiments were carried out in a column packed with glass beads of diameter 0.40 to 0.52 mm. Salt water was injected through nine holes at the bottom and withdrawn through nine holes at the top. Initially a low salt concentration was used which was then displaced with higher concentrated salt water. The salt mass-fraction was detected using an array of electrodes such that breakthrough curves were obtained at five different levels in the column. The report reviews a number of conceptual models and the corresponding numerical codes employed by different modelling teams. The experiments on one- and two-dimensional flow and transport were simulated by various groups. The question underlying the experiments, namely the applicability of Fick's laws over the whole range of salt concentration, could be addressed satisfactorily. All models could simulate low-concentration experiment using a dispersivity value of 0.8 mm to 1.00 mm. However, using the same dispersivity value, it was not possible to simulate high concentration experiments. Another question intended to be studied by the experiments was the validity of Darcy's law at high concentrations. Two-dimensional experiments were carried out for this purpose. In practice, calculations were hampered by extremely high demand on

  2. Project cost control in construction phase based on WSR%基于WSR的施工阶段工程造价控制

    Institute of Scientific and Technical Information of China (English)

    陈志鼎; 张晓芸; 郭琦

    2015-01-01

    In the construction phase of a project, the interplay of uncertain factors including long construction duration, the maximum cost of resources like labor and material, fluctuation of market prices, change of natural conditions will affect the reali-zation of the general target of the project. To effectively control the cost in construction phase, based on WSR ( Wuli which means Technical perspective in Chinese, Shili which means organizational perspective, Renli which means personal perspective) System Methodology, a WSR model of the project cost in construction phase is established to analyze the related elements in project cost control and management, draw up cost control aims and measures, which in turn will reduce the complexity of construction man-agement and provide effective methods for cost control in construction phase of different construction projects.%工程项目施工阶段,因工期长,人工、材料等资源消耗量大,市场价格波动、自然条件变化等不确定因素相互作用,会对工程项目总体目标的实现产生不利影响. 为有效控制该阶段的工程造价,利用WSR(物理-事理-人理)系统方法论,建立施工阶段工程造价的WSR模型,分析工程造价控制管理活动各环节的相关要素,制定控制目标及措施,以降低施工管理活动的复杂性,为不同建设项目施工阶段工程造价提供有效的控制方法.

  3. Project Maghreb - Europe: Solar Production of Hydrogen. Phase I: Feasibility and opportunity study of the project; Projet Maghreb - Europe: Production d'hydrogene solaire. Phase I: Etude d'opportunite et de faisabilite du projet

    Energy Technology Data Exchange (ETDEWEB)

    Mahmah, Bouziane; Belhamel, Maiouf; Chader, Samira; M' Raoui, Abdelhamid; Harouadi, Farid; Etievant, Claude; Lechevalier, Steve; Cherigui, Abdel-Nasser

    2007-07-01

    During the 16th World Hydrogen Energy Conference which held on June 13-16, 2006, in Lyon (France), an important project appeared, the Maghreb-Europe Project for production and export of solar hydrogen, proposed in the Algiers Declaration of the hydrogen of origin renewable and directed by the researchers efforts of the Renewable Energies Development Center of Algiers (CDER) and members of the European company of Hydrogen Technologies (CETH). The present introductory communication exposes a scientific study on the appropriateness and the feasibility of the Project, as well as the objectives, missions and the fundamental elements for a scientific and technique accompaniment of this important project. (auth)

  4. TU-F-17A-08: The Relative Accuracy of 4D Dose Accumulation for Lung Radiotherapy Using Rigid Dose Projection Versus Dose Recalculation On Every Breathing Phase

    International Nuclear Information System (INIS)

    Purpose: To investigate the accuracy of 4D dose accumulation using projection of dose calculated on the end-exhalation, mid-ventilation, or average intensity breathing phase CT scan, versus dose accumulation performed using full Monte Carlo dose recalculation on every breathing phase. Methods: Radiotherapy plans were analyzed for 10 patients with stage I-II lung cancer planned using 4D-CT. SBRT plans were optimized using the dose calculated by a commercially-available Monte Carlo algorithm on the end-exhalation 4D-CT phase. 4D dose accumulations using deformable registration were performed with a commercially available tool that projected the planned dose onto every breathing phase without recalculation, as well as with a Monte Carlo recalculation of the dose on all breathing phases. The 3D planned dose (3D-EX), the 3D dose calculated on the average intensity image (3D-AVE), and the 4D accumulations of the dose calculated on the end-exhalation phase CT (4D-PR-EX), the mid-ventilation phase CT (4D-PR-MID), and the average intensity image (4D-PR-AVE), respectively, were compared against the accumulation of the Monte Carlo dose recalculated on every phase. Plan evaluation metrics relating to target volumes and critical structures relevant for lung SBRT were analyzed. Results: Plan evaluation metrics tabulated using 4D-PR-EX, 4D-PR-MID, and 4D-PR-AVE differed from those tabulated using Monte Carlo recalculation on every phase by an average of 0.14±0.70 Gy, - 0.11±0.51 Gy, and 0.00±0.62 Gy, respectively. Deviations of between 8 and 13 Gy were observed between the 4D-MC calculations and both 3D methods for the proximal bronchial trees of 3 patients. Conclusions: 4D dose accumulation using projection without re-calculation may be sufficiently accurate compared to 4D dose accumulated from Monte Carlo recalculation on every phase, depending on institutional protocols. Use of 4D dose accumulation should be considered when evaluating normal tissue complication

  5. CPTAC Assay Portal: a repository of targeted proteomic assays

    Energy Technology Data Exchange (ETDEWEB)

    Whiteaker, Jeffrey R.; Halusa, Goran; Hoofnagle, Andrew N.; Sharma, Vagisha; MacLean, Brendan; Yan, Ping; Wrobel, John; Kennedy, Jacob; Mani, DR; Zimmerman, Lisa J.; Meyer, Matthew R.; Mesri, Mehdi; Rodriguez, Henry; Abbateillo, Susan E.; Boja, Emily; Carr, Steven A.; Chan, Daniel W.; Chen, Xian; Chen, Jing; Davies, Sherri; Ellis, Matthew; Fenyo, David; Hiltket, Tara; Ketchum, Karen; Kinsinger, Christopher; Kuhn, Eric; Liebler, Daniel; Lin, De; Liu, Tao; Loss, Michael; MacCoss, Michael; Qian, Weijun; Rivers, Robert; Rodland, Karin D.; Ruggles, Kelly; Scott, Mitchell; Smith, Richard D.; Thomas, Stefani N.; Townsend, Reid; Whiteley, Gordon; Wu, Chaochao; Zhang, Hui; Zhang, Zhen; Paulovich, Amanda G.

    2014-06-27

    To address these issues, the Clinical Proteomic Tumor Analysis Consortium (CPTAC) of the National Cancer Institute (NCI) has launched an Assay Portal (http://assays.cancer.gov) to serve as a public repository of well-characterized quantitative, MS-based, targeted proteomic assays. The purpose of the CPTAC Assay Portal is to facilitate widespread adoption of targeted MS assays by disseminating SOPs, reagents, and assay characterization data for highly characterized assays. A primary aim of the NCI-supported portal is to bring together clinicians or biologists and analytical chemists to answer hypothesis-driven questions using targeted, MS-based assays. Assay content is easily accessed through queries and filters, enabling investigators to find assays to proteins relevant to their areas of interest. Detailed characterization data are available for each assay, enabling researchers to evaluate assay performance prior to launching the assay in their own laboratory.

  6. The project for intercomparison of land-surface parameterization schemes (PILPS) phase 2(c) Red-Arkansas River basin experiment: 1. Experiment description and summary intercomparisons

    OpenAIRE

    Wood, EF; Lettenmaier, DP; Liang, X.; D. Lohmann; Boone, A.; Chang, S; Chen, F.; Dai, Y.; Dickinson, RE; Duan, Q; M. Ek; Gusev, YM; Habets, F.; Irannejad, P.; Koster, R

    1998-01-01

    Sixteen land-surface schemes participating in the project for the Intercomparison of Land-surface Schemes (PILPS) Phase 2(c) were run using 10 years (1979-1988) of forcing data for the Red-Arkansas River basins in the Southern Great Plains region of the United States. Forcing data (precipitation, incoming radiation and surface meteorology) and land-surface characteristics (soil and vegetation parameters) were provided to each of the participating schemes. Two groups of runs are presented. (1)...

  7. "Lunar Phases Project" as a Foundation for the Development of Innovative Inquiry Based ASTRO 101 Activities Utilizing Existing Concept Inventories as Assessment Tools

    Science.gov (United States)

    Mon, M. J.; Meyer, A. O.

    2012-08-01

    The cause and process of the lunar phases are difficult concepts for undergraduates and non-science majors to grasp. At Florida Gulf Coast University (FGCU) we have combined an inquiry-based instructional method (Mental Model Building) which can be more effective increasing students' conceptual understanding of the lunar phase cycle, together with the students' own observations. Undergraduate and non-science major students completed a hands-on project designed to integrate real observations, application of the scientific method, and Mental Model Building to connect the students' own observations to the Earth-Sun-Moon orientations responsible for their findings. Students' learning was assessed by administering the Lunar Phases Concept Inventory (developed by Rebecca S. Lindell and James P. Olsen, Southern Illinois University) before and after students completed the project, with positive results. We describe the methodology and activities utilized in our Lunar Phases Project, and propose their expansion to a variety of astronomical topics for undergraduate non-science majors and pre-service teachers. We emphasize developing and implementing new instructional strategies through the expansion of the Mental Model Building and similar pedagogical methodologies to develop innovative inquiry-based projects and activities in a variety of astronomical topics for undergraduate non-science majors and pre-service teachers. In order to meaningfully assess the new curriculum tools, we recommend utilizing already existing research-validated concept inventories specific to the astronomy content in the curriculum tools. These inventories can be analyzed to determine the conceptual learning gains achieved by the participating students and with further analysis can be used to refine portions of the activity under study.

  8. The Harvard/Brown Anxiety Research ProjectPhase II (HARP-II): Rationale, methods, and features of the sample at intake

    OpenAIRE

    Weisberg, Risa B.; Beard, Courtney; Dyck, Ingrid; Keller, Martin B.

    2012-01-01

    We describe the rationale, method, and intake demographic and clinical findings of the Harvard/Brown Anxiety Research Project-Phase II (HARP-II). HARP-II is the first prospective, observational, longitudinal study to describe the characteristics and course of anxiety in African American, Latino, and Non-Latino White individuals. Participants met criteria for at least one of the following disorders: Generalized Anxiety Disorder, Social Phobia, Panic Disorder with or without Agoraphobia, Agorap...

  9. Interim Evaluation of the Secondary 2 Program of Project P.A.T.H.S.: Insights Based on the Experimental Implementation Phase

    OpenAIRE

    Shek, Daniel T. L.; Sun, Rachel C. F.; Siu, Andrew M. H.

    2008-01-01

    An interim evaluation was conducted to understand the implementation quality of the Tier 1 Program (Secondary 2 Curriculum) of the Project P.A.T.H.S. (Positive Adolescent Training through Holistic Social Programs) in the Experimental Implementation Phase. Twenty-five schools were randomly selected to participate in personal and/or telephone interviews to provide information on the implementation details of the program and perceived attributes of the worker-support scheme (“Co-Walker Scheme”)....

  10. Transgenic Animal Mutation Assays

    Institute of Scientific and Technical Information of China (English)

    Tao Chen; Ph.D.D.A.B.T.

    2005-01-01

    @@ The novel transgenic mouse and rat mutation assays have provided a tool for analyzing in vivo mutation in any tissue, thus permitting the direct comparison of cancer incidence with mutant frequency.

  11. The neutral comet assay

    International Nuclear Information System (INIS)

    The single-cell gel electrophoresis (or comet) assay is a rapid and sensitive fluorescence microscopic method that is used for the detection of DNA damage at the individual cell level. Comet assay under neutral conditions allows the detection of DNA double-strand breaks, considered to the biologically relevant radiation-induced lesion. In this report we describe modifications of the neutral comet method and its use for studying DNA damage and its repair in irradiated human lymphocytes. (author)

  12. The Manhattan Court Employment Project. Summary Report on Phase One: November 1, 1967, to October 3, 1969.

    Science.gov (United States)

    Vera Inst. of Justice, New York, NY.

    This report on the first 2 years of a projected 3-year project describes an attempt to use counseling and job placement to divert some arrestees from possible jail sentences. Arrestees who meet the criteria for acceptance into the program are granted a 90-day continuance, during which time the staff representative, who is an ex-offender himself,…

  13. Protocol Development for the NASA-JSC Lunar-Mars Life Support Test Project (LMLSTP) Phase 3 Project: A Report on Baseline Studies at KSC for Continuous Salad Production

    Science.gov (United States)

    Goins, G. D.; Yorio, N. C.; Vivenzio, H. R.

    1998-01-01

    The Phase 3 Lunar-Mars Life Support Test Project (LMLSTP) was conducted in a 20-foot chamber at Johnson Space Center. The overall objective of the Phase 3 project was to conduct a 90-day regenerative life support system test involving 4 human subjects to demonstrate an integrated biological and physicochemical life support system. A secondary objective of the Phase 3 LMLSTP was to demonstrate the ability to produce salad-type vegetable by integration of a small benchtop growth chamber located within the crew habitat area. This small chamber, commercially manufactured as the Controlled Environment Research Ecosystem (CERES 2010(TM)), functioned as a means to continuously provide fresh lettuce crops for crew members. The CERES 2010(TM) growth chamber utilized hardware components developed for effective plant biomass production in spaceflight applications. These components included: (1) LED lighting; (2) Astroculture(TM) Root Trays; and (3) Zeoponic media. In planning for the LMLSTP Phase 3, a request was put forward for KSC scientists to generate a protocol for successful continuous planting, culturing, and harvesting of the salad-crop, lettuce. By conducting baseline tests with components of the CERES 2010(TM), a protocol was developed.

  14. Annual report on the Background Soil Characterization Project on the Oak Ridge Reservation, Oak Ridge, Tennessee: Results of Phase 1 investigation

    Energy Technology Data Exchange (ETDEWEB)

    Watkins, D.R.; Goddard, P.L.; Hatmaker, T.L.; Hook, L.A.; Jackson, B.L.; Kimbrough, C.W.; Lee, S.Y.; Lietzke, D.A.; McGin, C.W.; Nourse, B.D.; Schmoyer, R.L.; Shaw, R.A.; Stinnette, S.E.; Switek, J.; Wright, J.C. [Oak Ridge National Lab., TN (United States); Ammons, J.T.; Branson, J.L.; Burgoa, B.B. [Tennessee Univ., Knoxville, TN (United States). Dept. of Plant and Soil Science; Lietzke, D.A. [Lietzke (David A.), Rutledge, TN (United States)

    1993-05-01

    Many constituents of potential concern for human health occur naturally at low concentrations in undisturbed soils. The Background soil Characterization Project (BSCP) was undertaken to provide background concentration data on potential contaminants in natural soils on the Oak Ridge Reservation (ORR). The objectives of the BSCP are to provide baseline data for contaminated site assessment and estimates of potential human health risk associated with background concentrations of hazardous and other constituents in native soils. This report presents, evaluates, and documents data and results obtained in Phase I of the project. It is intended to be a stand-alone document for application and use in structuring and conducting remedial investigation and remedial action projects in the Environmental Restoration (ER) Program.

  15. Annual report on the Background Soil Characterization Project on the Oak Ridge Reservation, Oak Ridge, Tennessee: Results of Phase 1 investigation

    International Nuclear Information System (INIS)

    Many constituents of potential concern for human health occur naturally at low concentrations in undisturbed soils. The Background soil Characterization Project (BSCP) was undertaken to provide background concentration data on potential contaminants in natural soils on the Oak Ridge Reservation (ORR). The objectives of the BSCP are to provide baseline data for contaminated site assessment and estimates of potential human health risk associated with background concentrations of hazardous and other constituents in native soils. This report presents, evaluates, and documents data and results obtained in Phase I of the project. It is intended to be a stand-alone document for application and use in structuring and conducting remedial investigation and remedial action projects in the Environmental Restoration (ER) Program

  16. Even aberration measurement of lithographic projection optics based on intensity difference of adjacent peaks in alternating phase-shifting mask image

    International Nuclear Information System (INIS)

    We propose an in situ technique for measuring an even aberration of lithographic projection optics. By using the Hopkins theory of partially coherent imaging and the thick-mask model, the linear relationship between the intensity difference of adjacent peaks in an alternating phase-shifting mask image and an even aberration is established by equations and verified by numerical results. The sensitivity of measuring the even aberration of lithographic projection optics based on this linear relationship is analyzed, and the measurement mark is designed accordingly. Measurement performance of the present technique is evaluated using the lithographic simulator PROLITH, which shows that the present technique is capable of measuring the even aberration of lithographic projection optics with ultrahigh measurement accuracy.

  17. Proximity assays for sensitive quantification of proteins

    Directory of Open Access Journals (Sweden)

    Christina Greenwood

    2015-06-01

    Full Text Available Proximity assays are immunohistochemical tools that utilise two or more DNA-tagged aptamers or antibodies binding in close proximity to the same protein or protein complex. Amplification by PCR or isothermal methods and hybridisation of a labelled probe to its DNA target generates a signal that enables sensitive and robust detection of proteins, protein modifications or protein–protein interactions. Assays can be carried out in homogeneous or solid phase formats and in situ assays can visualise single protein molecules or complexes with high spatial accuracy. These properties highlight the potential of proximity assays in research, diagnostic, pharmacological and many other applications that require sensitive, specific and accurate assessments of protein expression.

  18. Plants Bioassays: Comet Assay on Higher Plants

    Czech Academy of Sciences Publication Activity Database

    Mukherjee, A.; Gichner, Tomáš

    Houston: Studium Press, 2009 - (Sampietro, D.; Narwal, S.), s. 97-108 ISBN 1-933699-42-6 R&D Projects: GA ČR GA521/05/0500 Institutional research plan: CEZ:AV0Z50380511 Keywords : Comet assay * DNA damage * Plants Subject RIV: EB - Genetics ; Molecular Biology

  19. The OECD validation program of the H295R steroidogenesis assay for the identification of in vitro inhibitors and inducers of testosterone and estradiol production. Phase 2: Inter-laboratory pre-validation studies

    DEFF Research Database (Denmark)

    Hecker, Markus; Hollert, Henner; Cooper, Ralph;

    2007-01-01

    chemicals that may interfere with endocrine systems of vertebrates. Here we report on studies that were conducted to develop and standardize a cell-based screening assay using the H295R cell line to prioritize chemicals that may act on steroidogenic processes in humans and wildlife. These studies are......Background, Goals and Scope. In response to concerns that have been raised about chemical substances that may alter the function of endocrine systems and result in adverse effects on human health, an OECD initiative was undertaken to develop and validate in vitro and in vivo assays to identify...... currently ongoing as part of the 'Special Activity on the Testing and Assessment of Endocrine Disruptors' within the OECD Test Guidelines Program to review, develop, standardize, and validate a number of in vitro and in vivo toxicological assays for testing and assessment of chemicals concerning their...

  20. Low-Cost, High-Performance Combustion Chamber for LOX/CH4 Propulsion, Phase II Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this project, Ultramet is designing and fabricating a lightweight, high temperature combustion chamber for use with cryogenic liquid oxygen/methane (LOX/CH4)...