WorldWideScience

Sample records for asociada con preeclampsia

  1. PERFIL CLÍNICO DE EMBARAZADAS CON PREECLAMPSIA Y EMBARAZOS NO COMPLICADOS

    OpenAIRE

    2004-01-01

    Objetivo: Conocer las variables clínicas y de laboratorio de más frecuente presentación en pacientes con preeclampsia (PE) de dos hospitales de la Quinta Región. Pacientes y Métodos: Estudio prospectivo caso-control. Se estudiaron 44 mujeres con PE sin patología asociada divididas en dos grupos; uno con 25 embarazadas con PE moderada (PEM) y otro de 19 con PE severa (PES), y grupo control de 30 embarazadas normales. Resultados: El índice de masa corporal basal fue de 24,1 ± 4 para el grupo co...

  2. Hiperalgesia asociada al tratamiento con opioides

    OpenAIRE

    Gil Martín, A.; M. Moreno García; J. Sánchez-Rubio Ferrández; T. Molina García

    2014-01-01

    La hiperalgesia inducida por opioides es una reacción paradójica caracterizada por una percepción intensificada de dolor relacionada con el uso de estos medicamentos en ausencia de progresión de la enfermedad o de síndrome de retirada. A diferencia de los casos de tolerancia, definida como pérdida de potencia analgésica durante el uso prolongado de opioides, no se produce mejoría con el escalado de dosis. La hiperalgesia inducida por opioides se ha manifestado en pacientes con dosis de manten...

  3. Hiperalgesia asociada al tratamiento con opioides

    Directory of Open Access Journals (Sweden)

    A. Gil Martín

    2014-10-01

    Full Text Available La hiperalgesia inducida por opioides es una reacción paradójica caracterizada por una percepción intensificada de dolor relacionada con el uso de estos medicamentos en ausencia de progresión de la enfermedad o de síndrome de retirada. A diferencia de los casos de tolerancia, definida como pérdida de potencia analgésica durante el uso prolongado de opioides, no se produce mejoría con el escalado de dosis. La hiperalgesia inducida por opioides se ha manifestado en pacientes con dosis de mantenimiento y retirada, pacientes con dosis elevadas o escalado de dosis y pacientes con dosis ultra bajas. Para establecer un diagnóstico diferencial es importante tener en cuenta que un incremento de dosis puede producir una mejoría temporal en pacientes con tolerancia pero no en los que han desarrollado hiperalgesia. La prevalencia de dicho fenómeno es desconocida, pero puede ser más frecuente de lo esperado y muchas veces no reconocido. El mecanismo subyacente no está bien definido, pero existen diversos estudios experimentales tanto en modelos animales como en humanos en los que se observa que la hiperalgesia no está desencadenada por un único factor, sino que son muchos los implicados. Entre los mecanismos propuestos destacan: la mediación del receptor NMDA (N-metil-D-aspartato activado por la liberación presináptica de glutamato, la modulación por la proteína-kinasa de calcio/calmodulina, el aumento en el número de nociceptores o la liberación de neurotransmisores excitadores. Se han realizado diversos estudios para describir la expresión y la relevancia de la hiperalgesia inducida por opioides en distintos grupos de pacientes: ex-adictos a opioides en tratamiento de mantenimiento con metadona, en exposición perioperatoria, en voluntarios sanos o en dolor crónico. Existen diferentes estrategias de tratamiento disponibles; entre las más aceptadas se encuentra la reducción en la dosis del opioide utilizado, la rotación del

  4. Rabdomiolisis asociada al tratamiento con valaciclovir

    Directory of Open Access Journals (Sweden)

    Héctor Enríquez Gómez

    2012-03-01

    Full Text Available La rabdomiolisis es un efecto secundario asociado a un buen número de fármacos, entre ellos los antivirales. Describimos un caso de rabdomiolisis secundaria a valaciclovir, efecto no descrito anteriormente en laliteratura, en un contexto clínico muy especial. Se trata de un varón queingresa por un golpe de calor secundario a la realización de ejercicio físicoextremo. Durante su ingreso se comienza tratamiento con valaciclovir porun herpes nasolabial, observándose en los días siguientes una marcadaelevación de las cifras de CPK que desaparece con la suspensión del mismo. Proponemos, por tanto, que ante la administración de valaciclovir ensituaciones que puedan comportar daño mitocondrial habría que realizarmonitorización estrecha de los niveles de CPK

  5. Rabdomiolisis asociada al tratamiento con valaciclovir

    OpenAIRE

    Héctor Enríquez Gómez; Javier De La Fuente Aguado; Laura González Vázquez; María Soledad Rodríguez Pecci

    2012-01-01

    La rabdomiolisis es un efecto secundario asociado a un buen número de fármacos, entre ellos los antivirales. Describimos un caso de rabdomiolisis secundaria a valaciclovir, efecto no descrito anteriormente en laliteratura, en un contexto clínico muy especial. Se trata de un varón queingresa por un golpe de calor secundario a la realización de ejercicio físicoextremo. Durante su ingreso se comienza tratamiento con valaciclovir porun herpes nasolabial, observándose en los días siguientes una ma...

  6. Especies mexicanas de Curculionidae (Insecta: Coleoptera) asociadas con agaves (Asparagaceae: Agavoideae)

    OpenAIRE

    Alberto Romo; Morrone, Juan J.

    2012-01-01

    Se estudiaron las especies de picudos o gorgojos (Coleoptera: Curculionidae) asociadas con agaves (Asparagaceae: Agavoideae) en México. Se registraron 5 especies asociadas con especies de Agave, Furcraea, Hesperoyucca, Polianthes y Yucca; de éstas, 4 pertenecen a la subfamilia Dryophthorinae (Scyphophorus acupunctatus, S. yuccae, Rhinostomus frontalis y Cactophagus spinolae) y 1 a la Baridinae (Peltophorus polymitus). Se presentan diagnosis, ilustraciones y una clave para la identificación de...

  7. Preeclampsia

    Science.gov (United States)

    ... induced hypertension (PIH); Gestational hypertension; High blood pressure - preeclampsia ... The exact cause of preeclampsia is unknown. It occurs in about 3% to 7% of all pregnancies. Autoimmune disorders Blood vessel problems Your diet Your ...

  8. Endocarditis infecciosa asociada con dispositivos electrónicos implantables intracardíacos. Nuestra experiencia

    Directory of Open Access Journals (Sweden)

    Fabián Salmo

    2007-01-01

    Full Text Available IntroducciónLa endocarditis infecciosa es una patología con una morbimortalidad elevada. En esta comunicación se presentan 17 casos de endocarditis infecciosa (EI asociada con dispositivos electrónicos implantables (DEI, que representaron el 6% de las endocarditis entre 1992 y 2005.ObjetivoAnalizar las características clínicas, evolutivas y anatomopatológicas de un subgrupo de pacientes con EI portadores de DEI.Material y métodosDe un total de 263 pacientes con EI admitidos en nuestra institución entre 1992 y 2005, se analizaron 17 con EI asociada con DEI.Las EI asociadas con DEI se clasificaron en: 1 temprana, la ocurrida dentro de los 12 meses del posquirúrgico, y 2 tardía, la producida luego de ese lapso. En todos los pacientes se obtuvieron muestras para hemocultivos, se efectuó el cultivo de todo material extraído durante la cirugía y se realizaron ecocardiogramas por vía transtorácica (ETT y transesofágica (ETE.ResultadosDe los 17 pacientes, 13 (73% eran hombres; la edad promedio fue de 60 años y el tiempo entre el implante y el diagnóstico fue de 344 días. Dieciséis pacientes presentaron fiebre y bacteriemia; el germen predominante fue Staphylococcus aureus en el 70% de los casos. En todos se extrajo el sistema. La mortalidad fue del 17%.ConclusionesLa EI asociada con el DEI, que debe sospecharse siempre en ausencia de otro foco infeccioso, constituye un subgrupo que con diagnóstico y tratamiento precoz tiene una mortalidad menor que la global descripta. Al igual que para la EI sin DEI, los hemocultivos y la ecocardiografía son los pilares para el diagnóstico.

  9. Paniculitis mesentérica asociada con absceso intraabdominal

    OpenAIRE

    2008-01-01

    La paniculitis mesentérica es una enfermedad inflamatoria del tejido adiposo del mesenterio, de presentación infrecuente y que se caracteriza, por el engrasamiento, endurecimiento y nodularidad del mismo. Se pone en consideración un caso clínico en un varón joven, con una forma de presentación poco común que requirió de laparotomía exploradora para realizar el diagnóstico y tratamiento.

  10. Sobrecarga asociada con el cuidado de ancianos dependientes

    Directory of Open Access Journals (Sweden)

    José Mauricio Ocampo

    2007-03-01

    Full Text Available Objetivo: Determinar la frecuencia y los factores asociados con la presencia de sobrecarga para el cuidador en ancianos dependientes. Diseño: Estudio piloto comparativo y observaciones de corte transversal.Pacientes y métodos: Se evaluaron 35 pacientes ancianos (>60 años residentes en la comunidad de la ciudad de Buenaventura (Valle del Cauca, Colombia, que tuvieran un puntaje en el índice de Barthel <85 puntos y cuidador, entre marzo y mayo de 2006. Se evaluaron las variables socio-demográficas en el anciano y en el cuidador, así como las variables biomédicas. Para evaluar la esfera mental se aplicó la prueba de Minimental y para la depresión la escala de Depresión Geriátrica de Yesavage. En la valoración social se empleó la escala de APGAR familiar, para determinar la carga del cuidado la escala de Zarit y para la valoración funcional se utilizó el índice de Barthel. Resultados: El promedio de edad y la desviación estándar (DE del grupo de pacientes fue 78.9±10 años. Se observó una mayor proporción de mujeres (68.5%. En los cuidadores, el promedio de edad y la DE fue 49.4±18.8 años, 91% eran mujeres. Se encontró que en 54.2% de los cuidadores no había sobrecarga, 40% presentaban una sobrecarga leve y el resto presentaba una sobrecarga intensa. Al realizar análisis bivariado entre la presencia de sobrecarga para el cuidador con número de enfermedades crónicas, puntajes en las escalas de la prueba de Minimental, depresión geriátrica y APGAR familiar se observaron asociaciones estadísticas (p<0.02. Se observó asociación significativa entre el grado de dependencia en las actividades básicas cotidianas (ABC en el aspecto físico con la presencia de sobrecarga para el cuidador (p<0.001.Conclusiones: Los ancianos dependientes en las actividades básicas cotidianas en el aspecto físico se asociaron con la carga percibida por el cuidador. Como los familiares son los principales cuidadores, los futuros estudios se

  11. Prevalencia de sustancias psicoactivas asociadas con muertes violentas en Cali.

    Directory of Open Access Journals (Sweden)

    Pablo A. Bravo

    2009-11-01

    Full Text Available Introducción: El consumo de sustancias psicoactivas se considera un problema mundial que repercute tanto en el sector social, económico y político como en el de salud. Según diferentes estudios, las muertes por violencia tales como accidentes de tránsito, suicidios y homicidios, se fundamentan en el hecho que existe una fuerte influencia del alcohol y otras sustancias psicoactivas. Objetivo: Estimar la prevalencia de sustancias psicoactivas en las muestras biológicas obtenidas durante el procedimiento de necropsia, que fueron analizadas en el laboratorio de Toxicología del Instituto Nacional de Medicina Legal y Ciencias Forenses Regional Suroccidente de Cali, Colombia. Métodos: Estudio transversal de los casos de muerte violenta ocurridos en Cali durante el período de enero de 1998 a junio de 2002 donde se efectuaron 17.434 necropsias, en las cuales se realizó un muestreo aleatorio sistemático y se analizaron 404 casos. Resultados: Del total de las muertes, 50% se presentaron en menores de 30 años y 84.8% eran hombres. La manera más frecuente de muerte fue por homicidio (53.7%, seguida por muerte natural (17.8%, accidente de tránsito (15.5%, accidental (6.7% y suicidio (6.2%. La prevalencia de sustancias psicoactivas (alcoholemia más drogas de abuso y tóxicas fue 31.9%, alcoholemia 23.7% y drogas de abuso y sustancias tóxicas 29.2%. La cocaína (21.2% y la marihuana (14.1% fueron las drogas de abuso más prevalentes. En 47.4% de los suicidios se encontró evidencias de sustancias psicoactivas siendo muy variadas las drogas utilizadas. En homicidio, 35.2% tuvo hallazgo de psicotrópicos. Conclusión: La tercera parte de las muertes violentas ocurridas en Cali se asociaron con el consumo de sustancias psicoactivas. Sin lugar a dudas es un llamado de atención para implementar medidas preventivas que enfrenten este problema de salud pública que interesa a todos los sectores.

  12. Prevalencia de sustancias psicoactivas asociadas con muertes violentas en Cali

    Directory of Open Access Journals (Sweden)

    Pablo A. Bravo

    2005-09-01

    Full Text Available Introducción: El consumo de sustancias psicoactivas se considera un problema mundial que repercute tanto en el sector social, económico y político como en el de salud. Según diferentes estudios, las muertes por violencia tales como accidentes de tránsito, suicidios y homicidios, se fundamentan en el hecho que existe una fuerte influencia del alcohol y otras sustancias psicoactivas. Objetivo: Estimar la prevalencia de sustancias psicoactivas en las muestras biológicas obtenidas durante el procedimiento de necropsia, que fueron analizadas en el laboratorio de Toxicología del Instituto Nacional de Medicina Legal y Ciencias Forenses Regional Suroccidente de Cali, Colombia. Métodos: Estudio transversal de los casos de muerte violenta ocurridos en Cali durante el período de enero de 1998 a junio de 2002 donde se efectuaron 17.434 necropsias, en las cuales se realizó un muestreo aleatorio sistemático y se analizaron 404 casos. Resultados: Del total de las muertes, 50% se presentaron en menores de 30 años y 84.8% eran hombres. La manera más frecuente de muerte fue por homicidio (53.7%, seguida por muerte natural (17.8%, accidente de tránsito (15.5%, accidental (6.7% y suicidio (6.2%. La prevalencia de sustancias psicoactivas (alcoholemia más drogas de abuso y tóxicas fue 31.9%, alcoholemia 23.7% y drogas de abuso y sustancias tóxicas 29.2%. La cocaína (21.2% y la marihuana (14.1% fueron las drogas de abuso más prevalentes. En 47.4% de los suicidios se encontró evidencias de sustancias psicoactivas siendo muy variadas las drogas utilizadas. En homicidio, 35.2% tuvo hallazgo de psicotrópicos. Conclusión: La tercera parte de las muertes violentas ocurridas en Cali se asociaron con el consumo de sustancias psicoactivas. Sin lugar a dudas es un llamado de atención para implementar medidas preventivas que enfrenten este problema de salud pública que interesa a todos los sectores.

  13. Evaluación de la memoria declarativa asociada con contenido emocional en pacientes lobectomizados

    Directory of Open Access Journals (Sweden)

    Silvia Botelho

    2008-01-01

    Full Text Available La participación del lóbulo temporal en la memoria para eventos emocionales, ha sido evaluada utilizando la Prueba auditivo-visual, cuyo contenido emocional es presentado en narrativas complejas. El presente estudio examinó si el desempeño en el Token Test, afectaba la retención a largo plazo de información alertante emocionalmente en pacientes con lobectomía temporal unilateral. Se evaluaron 48 participantes, a quienes se les aplicó: Trail Making Test, Token Test y una Prueba auditivo-visual. De manera general, la ausencia del efecto de potenciación mnemónico encontrado en pacientes con lobectomía temporal izquierda no estuvo correlacionada con el rendimiento en el Token Test. En conjunto, se muestra la importancia de la integridad del lóbulo temporal izquierdo para la potenciación de la memoria declarativa asociada a contenido emocional

  14. Conducta de enfermedad y niveles de depresión en mujeres embarazadas con diagnóstico de preeclampsia

    Directory of Open Access Journals (Sweden)

    Stefano Vinaccia

    2006-01-01

    Full Text Available El objetivo de este estudio es determinar la conducta de enfermedad en las mujeres que presentan preeclampsia y su relación con la depresión. Un total de 60 mujeres embarazadas con preeclampsia y 60 mujeres con embarazo normal fueron comparadas en conducta de enfermedad y depresión en un diseño transversal. La conducta de enfermedad fue evaluada mediante la versión española del Illness Behaviour Questionaire (IBQ. La depresión fue evaluada con la versión española del CES-D. Los resultados indican que las mujeres embarazadas con preeclampsia, comparadas con las embarazadas sin preeclampsia, presentaron niveles significativamente más altos (p<0,001 en depresión y en las siguientes subescalas del IBQ: hipocondría, convicción de enfermedad, negación del problema, irritabilidad y distorsión afectiva. No se encontraron diferencias significativas en percepción psicológica versus somática de la enfermedad ni tampoco en inhibición afectiva. Los resultados sugieren que las embarazadas con preeclampsia tienen una peor conducta de enfermedad que las embarazadas sin preeclampsia.

  15. Diagnóstico prenatal de ciclopía asociada con trisomía 13

    Directory of Open Access Journals (Sweden)

    Harry Pachajoa

    2008-03-01

    Full Text Available Se presenta un caso de ciclopía con diagnóstico prenatal por ecografía bidimensional y tridimensional, a quien se le realizó cordocentesis, el cariotipo en sangre fetal con bandeo G mostró trisomía 13 libre, las características fenotípicas se confirmaron al examen físico del recién nacido. Se hace una revisión de la literatura de ciclopía asociada con la trisomía 13 y se destacan aspectos de importancia en la ecografía prenatal.

  16. Lipidosis hepática asociada con malnutrición y preñez en dos perras

    OpenAIRE

    2004-01-01

    En algunos países latinoamericanos se observó que la ascites ocurre en diferentes momentos post parto en perras alimentadas con dietas hipoproteicas. El objetivo de este articulo fue describir 2 casos de perras con ascitis asociada a lipidosis hepática desarrollada después del parto. Las muestras de sangre evidenciaron anormarmalidades compatibles con enfermedad hepática. La paracentesis abdominal reveló un trasudado aséptico y la ultrasonografía hiperecogenicidad hepática. Se arribó al diagn...

  17. Concordancia entre el gram y el cultivo del lavado broncoalveolar en pacientes con neumonía asociada al ventilador

    OpenAIRE

    Varón, Fabio Andrés; Buitrago, Alberto Fernando

    2010-01-01

    La neumonía asociada a ventilador (NAV) es una entidad de incidencia creciente en cuidado intensivo con grandes dificultades en la estandarización de pruebas diagnósticas, generando altos costos en su manejo. Realizar un abordaje diagnóstico apropiado para cada institución y conocer la flora causante permite un mejor desenlace clínico y ahorro significativo para el sistema. Métodos diagnósticos sencillos como la tinción gram de muestras respiratorias son ampliamente usados para NAV, pero se o...

  18. Rehabilitación pulmonar aislada versus asociada a un suplemento nutricional específico en pacientes con bronquiectasias

    OpenAIRE

    2015-01-01

    La rehabilitación respiratoria (RR) es una pieza básica en el tratamiento de enfermedades pulmonares crónicas pero no ha sido suficientemente estudiada en Bronquiectasias (BQ). Los suplementos nutricionales podrían mejorar los resultados. Objetivos: Comparar el efecto de la RR aislada vs asociada a un suplemento hiperproteico enriquecido en beta-hidroxy-beta-metilbutirato (HMB) en pacientes con BQ sobre la respuesta clínica y biológica. Material y métodos: Estudio prospectivo al...

  19. Massive vulval edema with severe preeclampsia. Case report Edema vulvar masivo con preeclampsia grave. Presentación de un caso.

    Directory of Open Access Journals (Sweden)

    José Luis Gómez Miranda.

    2009-11-01

    Full Text Available Massive vulval edema with severe preeclampsia is presented as one of the consequences that may appear on patients with hypertension disorders during pregnancy, therefore the attention in the Obstetrics and Gynecology Service must be systematical and permanent. On women with hypertensive disorders during pregnancy, although edemas may not be constant, they may either appear at minor, barely perceptible extents, or even in the most severe ways, such as anasarca. A very peculiar manifestation of edema on preeclampsia is massive vulval edema, which appears as a highly rare complication, in whose basis there is a complex, systemic pathological process involved. We present a case of a pregnant woman who was admitted with high blood pressure values and excessive weight gain, plus very noticeable general edemas, and during her stay developed massive vulval edema. No data on this complication were found in the bibliography reviewed. Very few experienced professionals recall having dealt with similar cases in the last fifteen years, hence the decision to publish it.El edema vulvar masivo con preeclampsia grave se presenta como una de las consecuencias que pueden aparecer en pacientes con trastornos de hipertensión en el embarazo, por lo que la atención en el Servicio de Obstetricia debe ser sistemática y permanente. En las mujeres con trastornos hipertensivos del embarazo, los edemas, aunque no son constantes, se manifiestan desde las formas más leves, apenas perceptibles, hasta las más severas, como la anasarca. Una manifestación particular del edema en la preeclampsia, es el edema vulvar masivo, que se presenta como una complicación sumamente rara, en cuya base hay un proceso patológico sistémico y complejo. Se presenta el caso de una embarazada que ingresó con cifras elevadas de presión arterial y aumento de peso exagerado, con edemas generalizados muy acentuados, que durante su estancia desarrolló un edema vulvar masivo. En la bibliograf

  20. Biomarcadores del estado inflamatorio: nexo de unión con la obesidad y complicaciones asociadas

    OpenAIRE

    2007-01-01

    El objetivo de este trabajo ha consistido en realizar una revisión de los biomarcadores que actualmente se proponen como el nexo de unión entre la inflamación, la obesidad y complicaciones asociadas, seleccionando los estudios llevados a cabo y las cuestiones pendientes. Cada vez hay mayor evidencia científica de que la inflamación puede jugar un papel importante en la etiología de diversas enfermedades crónicas de gran relevancia para la salud pública. En los últimos ...

  1. Homocisteína y perfil de lípidos en embarazo normal y embarazo complicado con preeclampsia

    OpenAIRE

    Thelma Canto-Cetina; Lucila Polanco-Reyes; Mirna Ballote-Zapata; Manuel Ordóñez-Luna

    2014-01-01

    Antecedentes:la preeclampsia es una de las complicaciones severasmás comunes del embarazo. Es responsable, asimismo, de altas tasasde morbilidad y mortalidad maternoinfantiles. Estudios previos hanrevelado hallazgos contradictorios respecto a las concentraciones to-tales de homocisteína (Hcy) en mujeres con preeclampsia/eclampsiay existe poca información acerca de la relación entre concentracionesde lípidos séricos y homocisteína.Objetivo:comparar las concentraciones de lípidos y homocisteína...

  2. Effective treatment of common variable immunodeficiency associated diarrhea Diarrea asociada a inmunodeficiencia común variable tratada con budesonida

    Directory of Open Access Journals (Sweden)

    H. Córdova Guevara

    2009-03-01

    Full Text Available Common variable immunodeficiency disorder (CVID, the commonest symptomatic primary antibody deficiency syndrome, is characterised by recurrent bacterial infections, particularly of the upper and lower airways; it is also associated with an increased incidence of autoimmune and neoplastic disorders. CVID has a high prevalence of infectious, inflammatory and neoplastic gastrointestinal diseases. Up to 60% of the patients with non-treated CVID develop diarrhea and 10% associated idiopathic malabsorption with weight loss. The case of a 50-year-old woman with CVID-associated diarrhea, abdominal pain and bloating of one year's duration is reported. An exhaustive evaluation made for secondary causes of her symptoms was unrevealing; she was treated with loperamide and diet, without improvement. She later followed a course of oral budesonide for 3 months; her clinical symptoms disappeared and her quality of life improved. In conclusion, we report the case of a patient with CVID-related chronic diarrhea who responded well to oral budesonide treatment. This outcome provides the gastroenterologist with a new therapeutic option in this difficult group of patients.La inmunodeficiencia común variable (IDCV es la deficiencia primaria de anticuerpos sintomática más frecuente y está caracterizada por infecciones bacterianas recurrentes, especialmente de las vías aéreas superiores e inferiores, y también asociada a incremento de enfermedades autoinmunes y neoplasias. Presenta alta prevalencia de enfermedades gastrointestinales infecciosas, inflamatorias y neoplásicas. Hasta el 60% de los pacientes con IDCV no tratados desarrollan diarrea y el 10% desarrollan malabsorción idiopática asociado a pérdida de peso. Presentamos el caso de una mujer de 50 años con IDCV que presenta diarrea crónica, con dolor y distensión abdominal desde hace 1 año. Realizándose múltiples exploraciones y descartando causas secundarias de diarrea crónica, se inicia

  3. Disfagia orofaringea asociada con malformación de Chiari tipo I y siringomielia

    OpenAIRE

    2014-01-01

    Antecedentes: la disfagia con afección neurológica constituye un dato clínico significativo en el diagnóstico de lesiones que justifiquen la compresión del tronco cerebral y los nervios craneales bajos. o bjetivo: destacar la importancia del estudio de la disfagia en una pa - ciente con malformación de Chiari tipo I y siringomielia, sin síntomas gastroenterológicos primarios. Caso clínico: se comunica el caso de una mujer de 62 años de edad con disfagia orofaríngea de seis años de evolución, ...

  4. Disección de arterias coronarias asociada con el consumo de cocaína

    OpenAIRE

    Guillermo Marchetti; Juan Arellano; Flavio Salvaggio; Luis Gariglio; Gabriel Pérez Baztarrica; Alejandro Botbol; Rafael Porcile

    2008-01-01

    La disección espontánea de arterias coronarias es en extremo rara y escasamente documentada en la bibliografía mundial. Una de las causas en pacientes jóvenes es la adicción a la cocaína. Se presenta el caso de un paciente con historia de consumo reciente de cocaína que ingresa derivado por infarto de miocardio para cinecoronariografía y angioplastia. En la cinecoronariografía se evidencia una disección espontánea de la arteria descendente anterior con flujo TIMI III. Debido al contexto clíni...

  5. Variables asociadas a la cultura innovadora con TIC en escuelas rurales

    Directory of Open Access Journals (Sweden)

    Mª Esther del Moral Pérez

    2014-01-01

    Full Text Available La implantación del programa Escuela 2.0 (2010-2012 supuso un incremento de la dotación tecnológica en las escuelas rurales y exigió una actualización del profesorado para garantizar la integración de las TIC. Con la presente investigación -derivada del proyecto EDU2010-17037, MIC (2011-13- se analizan las opiniones de docentes innovadores (N=30 obtenidas mediante entrevistas semi-estructuradas, y se identifican las variables que -a su juicio- contribuyen en mayor medida a la consolidación de prácticas innovadoras con TIC en las escuelas rurales. Entre los resultados se constata que priorizan la utilidad de éstas, cifrada en el logro de resultados de aprendizaje óptimos, el incremento de la motivación de los alumnos y las oportunidades ofrecidas para potenciar las competencias digitales. También sobredimensionan su sensación de seguridad, derivada de saberse cualificados para manejar las TIC, pudiéndose ver mermada al no tener la garantía de contar con los recursos suficientes ni con la asistencia técnica necesaria que permita su utilización sin incidentes. Además, puntualizan que el reconocimiento de su tarea por parte de la administración, junto con el apoyo de sus colegas y las familias del alumnado, son claves para afianzar su condición de docente innovador. Por ello, demandan un mayor apoyo institucional para que las innovaciones no dependan del voluntarismo, consideran las comunidades de prácticas útiles para unir sinergias entre colegas y evitar el aislamiento, y echan de menos una mayor implicación de las familias. En conclusión, el desarrollo de proyectos innovadores en las escuelas rurales requiere de un clima propicio que ayude a sostener e impulsar la innovación desde el ámbito institucional, dotando al profesorado de una formación adecuada y otorgándole el debido reconocimiento y la remuneración oportuna.

  6. La osteonecrosis asociada al tratamiento con bisfosfonatos en osteoporosis primaria: Revisión de la literatura

    Directory of Open Access Journals (Sweden)

    A. Outeiriño-Fernández

    Full Text Available Fundamento. El propósito de esta revisión es identificar los factores de riesgo que pueden intervenir en el desarrollo de la osteonecrosis maxilar asociada a bisfosfonatos (OMB tras cirugía oral, en pacientes en tratamiento con bisfosfonatos (BP por osteoporosis primaria. Material y métodos. Con el fin de localizar las publicaciones de relevancia se llevó a cabo una búsqueda en bases de datos tanto de ámbito especializado, como general. La estrategia de búsqueda empleada fue osteonecrosis, bisfosfonatos y cirugía oral. Ésta fue limitada a estudios publicados desde el año 2006 a enero de 2012, en inglés y español realizados en humanos, adultos, tratados con bisfosfonatos por osteoporosis primaria y sometidos a cirugía dentoalveolar. Fueron incluidas revisiones sistemáticas, meta-análisis, guías de práctica clínica, ensayos clínicos aleatorizados y series de casos. Resultados. Se seleccionaron un total de 14 artículos (series de casos, que recogían un total de 43 casos de OMB. La mandíbula y la exodoncia fueron la localización y procedimiento odontológico más frecuente en relación con las lesiones descritas. La media de edad de los pacientes fue de 71,94 años, con predilección por el sexo femenino. El alendronato fue el fármaco empleado en la mayoría de los casos y la duración media de tratamiento previa a la aparición de OMB fue de 48,25 meses. Conclusiones. Son necesarios más estudios prospectivos y retrospectivos con un diseño adecuado para evaluar el peso real de cada uno de los factores considerados de riesgo para el desarrollo de la OMB.

  7. Resiliencia y Variables Asociadas en Cuidadores Informales de Pacientes con Alzheimer

    OpenAIRE

    2016-01-01

    La resiliencia es una variable protectora ante el rol del cuidador, por ello, este estudio pretende identificar la relación entre la resiliencia y la sobrecarga, la depresión, la percepción de apoyo social y estrategias de afrontamiento. Se trata de un estudio transversal de alcance correlacional que contó con una muestra de 101 cuidadores, evaluados por medio de los instrumentos Zarit, mos, ider , Coping, la Escala de Resiliencia de Wagnild y Young. Se identificaron correlaciones positi...

  8. Fractura de la apófisis coracoides asociada con luxación de la articulación acromio clavicular

    OpenAIRE

    Sánchez Alepuz, Eduardo; Peiró González, Ángel

    1995-01-01

    Las fracturas de la apófisis coracoides asociada con luxación de la articulación acromioclavicular y con rotura de los ligamentos coracoclaviculares en los adultos ocurren infrecuentemente. Este artículo añade otro caso más a la literatura, para enfatizar la importancia del reconocimiento de este tipo de lesiones. El diagnóstico se realiza mediante una radiografía anteroposterior y una lateral axial y/o la TAC. El tratamiento puede ser quirúrgico u ortopédico con mínimas altera...

  9. Infección natural de chinches Triatominae con Trypanosoma cruzi asociadas a la vivienda humana en México

    Directory of Open Access Journals (Sweden)

    Vidal-Acosta Vianey

    2000-01-01

    Full Text Available OBJETIVO: Informar el porcentaje de infección natural de las especies de triatóminos que habitan con mayor frecuencia el medio doméstico y peridoméstico en México, así como dar a conocer las localidades de colecta por estado. MATERIAL Y MÉTODOS: Se recibieron muestras de chinches Triatominae en el Departamento de Entomología del Instituto de Diagnóstico y Referencia Epidemiológicos, para su determinación taxonómica y la búsqueda parasitoscópica de Trypanosoma cruzi, provenientes de 14 estados del país, de enero de 1993 a diciembre de 1999. Se analizaron en conjunto los resultados obtenidos en esos años. RESULTADOS: De una muestra de 5 399 ejemplares, fueron 13 las especies de triatóminos asociadas a las viviendas. El porcentaje de infección natural tuvo una amplia variación entre las especies. De las estudiadas, nueve se encontraron con infección natural; el mayor porcentaje de infección corresponde a Triatoma pallidipennis, T. picturata, Rhodnius prolixus y T. longipennis. Los estados con mayor porcentaje de infección fueron Nayarit, Morelos y Michoacán. Se presentaron nuevos registros estatales de Triatoma dimidiata, T. gerstaeckeri, T. longipennis, T. mexicana y T. pallidipennis y uno local de Pastrongylus rufotuberculatus. Además, se informa por primera vez la infección natural en algunas de ellas. CONCLUSIONES: Se debe poner mayor énfasis en el estudio de la biología y aspectos bionómicos de los triatóminos y realizar una vigilancia permanente para tener los registros de distribución actualizados, así como para conocer los índices de infección natural por T. cruzi, de las especies domiciliarias, peridomiciliarias y de las que están en proceso de adaptación a la vivienda humana.

  10. Características neuropsicológicas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson.

    OpenAIRE

    Custodio, Nilton; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia. Clínica Internacional. Lima, Perú. Unidad de Investigación. Clínica Internacional. Lima, Perú. Servicio de Neurología. Clínica Internacional. Lima,; Bendezú, Liliana; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia. Clínica Internacional. Lima, Perú. Servicio de Neurología. Clínica Internacional. Lima; Castro-Suárez, Sheila; Servicio de Neurología de la Conducta. Instituto Nacional de Ciencias Neurológicas. Lima.; Herrera-Pérez, Eder; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia. Clínica Internacional. Lima. Unidad de Proyectos de Investigación. Instituto de Salud del Niño. Lima.; Lira, David; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia. Clínica Internacional. Lima, Perú. Unidad de Investigación. Clínica Internacional. Lima, Perú. Servicio de Neurología. Clínica Internacional. Lima,; Montesinos, Rosa; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia. Clínica Internacional. Lima.; Cortijo, Patricia; Servicio de Medicina de Rehabilitación. Clínica Internacional. Lima. Unidad de Neuropsicología. Clínica Internacional. Lima,; Núñez del Prado, Liza; Servicio de Neurología. Clínica Maisson de Sante. Lima.

    2014-01-01

    En la enfermedad de Parkinson (EP), las áreas cognitivas pueden estar íntegras (EP cognitivamente normales, EP-CN), o afectarse desde compromisos ligeros sin compromiso de la funcionalidad (deterioro cognitivo leve asociado a EP, DCL-EP), hasta franca alteración de ella (demencia asociada a la EP, DEP). Objetivos: Evaluar el rendimiento cognitivo de pacientes con EP en diversos estadios cognitivos y compararlos con un grupo control. Pacientes y métodos:Prospectivamente se formaron cuatro grup...

  11. Hallazgos clínicos y de laboratorio que sugieren tempranamente el síndrome de HELLP en pacientes con preeclampsia severa

    OpenAIRE

    García V,Victoria; Echavarría R,Luis Guillermo; Ardila C,Ricardo; Gutiérrez M,Jorge

    2014-01-01

    Objetivo: Determinar la utilidad de las pruebas de laboratorio y clínicas que se alteran de forma precoz para el diagnóstico del síndrome de HELLP en pacientes con preeclampsia severa. Métodos: Estudio observacional retrospectivo, de utilidad de prueba diagnóstica, basado en una cohorte clínica que incluyó mujeres embarazadas con diagnóstico de preeclampsia severa ingresadas entre el 4 de mayo del 2005 al 7 mayo del 2008 en la Clínica Universitaria Bolivariana (CUB). Se realizó comparación en...

  12. Modelos predictivos de resultado anatómico a largo plazo en degeneración macular asociada a a la edad (DMAE) exudativa tratada con ranibizumab

    OpenAIRE

    González Buendía, Lucía

    2016-01-01

    La degeneración macular asociada a la edad (DMAE) es la primera causa de pérdida de visión en personas mayores de 60 años en los países desarrollados.1 Actualmente, casi todos los pacientes que presentan la forma exudativa o neovascular de la enfermedad son sometidos a tratamiento con fármacos antiangiogénicos, dirigidos contra el factor de crecimiento vascular endotelial (vascular endothelial growth factor, VEGF), ya que estos fármacos han demostrado ser capaces de enlentecer la progresión e...

  13. La importancia de la dieta en la degeneración macular asociada a la edad y su relación con el pigmento macular

    OpenAIRE

    Delgado Melendro, Carlos

    2014-01-01

    La Degeneración macular asociada a la edad (DMAE), se define como una enfermedad degenerativa que cursa con alteraciones del epitelio pigmentario de la retina (EPR), la membrana de Bruch y la coriocapilaris. Las anomalías en el EPR provoca una degeneración del mismo y de los fotoreceptores de la retina central o área macular causando una pérdida de la visión central irreversible (Chen et al., 2010). La etapa inicial de la enfermedad se caracteriza por la presencia de drusas constituidas po...

  14. Caracterización de pacientes con bronconeumonía bacteriana asociada a la ventilación artificial mecánica

    OpenAIRE

    Danilo Eranio Utra Cardoso; Leonila Atencio González; Aida Esther Leyva Peña; Gladis Marrero Ávila; Idalia Arcias Castillo

    2015-01-01

    Fundamento: las neumonías nosocomiales constituyen hoy en día un problema de salud a nivel mundial. En las unidades de cuidados intensivos de las instituciones hospitalarias ingresa un elevado número de pacientes que requieren ventilación artificial mecánica, factor de riesgo asociado a este tipo de infecciones. Objetivo: caracterizar a los pacientes con neumonías bacterianas asociadas a la ventilación artificial mecánica, ingresados en la sala de cuidados intensivos del Hospital General D...

  15. Especies mexicanas de Curculionidae (Insecta: Coleoptera asociadas con agaves (Asparagaceae: Agavoideae Mexican species of Curculionidae (Insecta: Coleoptera associated to agaves (Asparagaceae: Agavoideae

    Directory of Open Access Journals (Sweden)

    Alberto Romo

    2012-12-01

    Full Text Available Se estudiaron las especies de picudos o gorgojos (Coleoptera: Curculionidae asociadas con agaves (Asparagaceae: Agavoideae en México. Se registraron 5 especies asociadas con especies de Agave, Furcraea, Hesperoyucca, Polianthes y Yucca; de éstas, 4 pertenecen a la subfamilia Dryophthorinae (Scyphophorus acupunctatus, S. yuccae, Rhinostomus frontalis y Cactophagus spinolae y 1 a la Baridinae (Peltophorus polymitus. Se presentan diagnosis, ilustraciones y una clave para la identificación de las 5 especies de curculiónidos asociados con agaves. Se establecen las siguientes sinonimias: Sphenophorus validus LeConte, 1858 = Cactophagus spinolae (Gyllenhal, 1838; y Zygops polymitus seminiveus LeConte, 1884, Z. p. leopardinus Desbrochers, 1891 y Z. p. suffusus Casey, 1892 = Peltophorus polymitus Boheman, 1845.Weevils (Coleoptera: Curculionidae associated with agaves (Asparagaceae: Agavoideae from Mexico are analyzed. Five species were recorded associated with species of Agave, Furcraea, Hesperoyucca, Polianthes, and Yucca. Four of these species belong to the subfamily Dryophthorinae (Scyphophorus acupunctatus, S. yuccae, Rhinostomus frontalis, and Cactophagus spinolae and 1 belongs to the subfamily Baridinae (Peltophorus polymitus. Diagnoses, illustrations and a key are presented for identifying the 5 species of weevils found on agaves. The following synonymies are established: Sphenophorus validus LeConte, 1858 = Cactophagus spinolae (Gyllenhal, 1838; and Zygops polymitus seminiveus LeConte, 1884, Z. p. leopardinus Desbrochers, 1891, and Z. p. suffusus Casey, 1892 = Peltophorus polymitus Boheman, 1845.

  16. PROMOCIÓN DEL CRECIMIENTO DE Baccharis macrantha (ASTERACEAE CON BACTERIAS SOLUBILIZADORAS DE FOSFATOS ASOCIADAS A SU RIZOSFERA

    Directory of Open Access Journals (Sweden)

    Luz Marina LIZARAZO FORERO

    2015-07-01

    Full Text Available El objetivo de esta investigación fue aislar y caracterizar bacterias solubilizadoras de fosfatos (BSF asociadas a la rizosfera de Baccharis macrantha y Viburnum triphyllum, y evaluar su capacidad para solubilizar fosfatos en condiciones in vitro. Además se determinó el efecto de la inoculaciónde las cepas de BSF más eficientes sobre el crecimiento de B. macrantha. Las muestras de suelo rizosférico de B. macrantha y V. triphyllum fueron colectadas en los meses de mayo-período de lluvia y septiembre-período seco del 2012. Para la cuantificación de bacterias heterótrofas cultivables y BSF se empleó el método de recuento en placa en los medios Agar Tripticasa de Soya y Pikovskaya (PVK respectivamente. La capacidad de solubilización de fosfatos de las cepas aisladas se estimó a partir del diámetro de los halos formados alrededor de las colonias en el medio de cultivo PVK después de 7 días de incubación a 28 °C. Los ensayos de inoculación en B. macrantha se realizaron con las BSF más eficientes. La inoculación de las BSF B. firmus y P. fluorescens de forma individual y como inoculante combinado mostro un efecto benéfico, incrementando significativamente el porcentaje de germinación de semillas, la altura de la plántula, la longitud de la raíz y el peso seco de B. macrantha. La inoculación de BSF podría ser considerada una estrategia para mejorar el crecimiento y establecimiento de B. macrantha en pastizales abandonados.Growth Promotion of Baccharis macrantha (Asteraceae by Phosphate Solubilizing Rhizosphere Bacteria     The objectives of this research was to isolate and characterize phosphate solubilizing bacteria (BSF associated to the rhizosphere of Baccharis macrantha and Viburnum triphyllum, and to assess their ability to solubilize phosphate under conditions in vitro. Furthermore to determine the effect of inoculation of the strains BSF more efficient on the growth of B. macrantha. Rhizosphere soil samples of B

  17. Susceptibilidad genética a desarrollar Cáncer de pulmón asociada con el gen polimórfico hidrolasa epoxida

    Directory of Open Access Journals (Sweden)

    Sierra CH.

    2001-06-01

    Full Text Available La enzima metabólica hidrolasa epóxida microsomal (mHE está involucrada en biotransforma-ción de carcinógenos del cigarrillo (ej., benzo-a-pireno. Este estudio investigó la susceptibilidad genética a desarrollar cáncer de pulmón asociada con los polimorfismos en los exones 3 y 4 delgen mHE, los cuales confieren reducida e incrementada actividad enzimática respectivamente. Además, se determinó su efecto en la frecuencia de aberraciones cromosómicas (AC como unamedida adicional de riesgo. La población de estudio incluyó 110 pacientes con cáncer de pulmóny 119 fumadores saludables.

  18. Contenido de N, P, K y rendimiento de frambuesa roja (Rubus idaeus L. ‘Autumn bliss’ orgánico asociada con lupino (Lupinus mutabilis Sweet.

    Directory of Open Access Journals (Sweden)

    Enoc Jara-Peña

    2013-06-01

    Full Text Available Este trabajo se realizó con el objetivo de determinar la respuesta de la frambuesa ‘Autumn Bliss’ productora de otoño a la aplicación de un biofertilizante (vermicomposta asociada con lupino, en condiciones de invernadero en Montecillo, México. En el ensayo se estudiaron 5 niveles de vermicomposta (0, 30, 60, 90 y 120 g maceta–1 y 2 niveles de asociación (con o sin lupino totalizando 10 tratamientos y un tratamiento adicional que consistió de fertilización química (N100 P80 K80 . Como material vegetal se utilizaron brotes adventicios de frambuesa tratadas con frío durante 60 días a 5 °C. Se encontraron diferencias estadísticamente significativas a los niveles de vermicomposta incorporada al sustrato, y niveles de 60 hasta 90 g maceta–1 favorecieron las mayores concentraciones de N y K en frambuesa. Cuando la frambuesa se asoció con lupino, permitió una mayor acumulación de P, lo que indica una interacción positiva entre estos elementos. El mayor rendimiento en peso y en número de frutos se obtuvo con la aplicación de 90 g maceta–1 de vermicomposta. Sin embargo, cuando la frambuesa se asoció con lupino el mayor rendimiento en peso y en número de frutos se obtuvo con aplicación de 120 g maceta–1 de vermicomposta.

  19. Factor de necrosis tumoral alfa en pacientes con preeclampsia a término y pretérmino

    Directory of Open Access Journals (Sweden)

    Eduardo Reyna Villasmil

    2012-07-01

    Full Text Available El objetivo de la investigación fue identificar y comparar las concentraciones de factor de necrosis tumoral alfa en pacientes con preeclampsia a término y pre-término. Se seleccionó un total de 50 pacientes. Se incluyeron a 20 pacientes preeclámpticas pre-término (grupo A y 30 preeclámpticas a término (grupo B. Las muestras de sangre para la determinación de factor de necrosis tumoral alfa se recolectaron en todas las pacientes antes del parto e inmediatamente después del diagnóstico de preeclampsia. No se encontraron diferencias significativas con relación a la edad materna e Índice de masa corporal al momento de la toma de la muestra. Se observaron diferencias estadísticamente significativas entre los grupos con respecto a la edad gestacional (p < 0,0001. El valor promedio de la presión arterial sistólica en el grupo A fue de 149,4 ± 11,3 mmHg mientras que en las pacientes del grupo B fue de 148,1 ± 12,3 mmHg (p = 0,7071 y el valor promedio de presión arterial diastólica en el grupo A fue de 103,8 ± 8,6 mmHg y en el grupo B fue de 102,7 ± 7,9 mmHg (p = 0,6436. Las concentraciones de factor de necrosis tumoral alfa fueron similares en el grupo de preeclámpticas pre-término (98,2 ± 45,1 pg/mL comparado con el grupo de preeclámpticas a término (96,6 ± 48,7 pg/mL; p = 0,9072. Al realizar la correlación entre los valores de factor de necrosis tumoral alfa con los valores de presión arterial se observó que no existía correlación con la presión arterial sistólica (r = 0,129; p = 0,374 ni con la de presión arterial diastólica (r = 0,158, p = 0,273. Se concluye que las concentraciones sanguíneas del factor de necrosis tumoral alfa resultaron similares en las pacientes preeclámpticas con embarazo pretérmino y a término. La correlación de las concentraciones de factor de necrosis tumoral alfa con los valores de presión arterial sistólica y diastólica resultó no significativa. Palabras clave:Factor de

  20. Caracterización de pacientes con bronconeumonía bacteriana asociada a la ventilación artificial mecánica

    Directory of Open Access Journals (Sweden)

    Danilo Eranio Utra Cardoso

    2015-06-01

    Full Text Available Fundamento: las neumonías nosocomiales constituyen hoy en día un problema de salud a nivel mundial. En las unidades de cuidados intensivos de las instituciones hospitalarias ingresa un elevado número de pacientes que requieren ventilación artificial mecánica, factor de riesgo asociado a este tipo de infecciones. Objetivo: caracterizar a los pacientes con neumonías bacterianas asociadas a la ventilación artificial mecánica, ingresados en la sala de cuidados intensivos del Hospital General Docente “Dr. Ernesto Guevara de la Serna”, Las Tunas, Cuba; durante el año 2012. Métodos: se realizó un estudio descriptivo, retrospectivo, en los pacientes (262 ingresados en esa unidad, en el período de enero a diciembre de 2012. La muestra quedó conformada por los 173 pacientes complicados por neumonías bacterianas. Los datos fueron tomados de los expedientes clínicos. Se midieron las variables: grupos de edad, manifestaciones radiológicas, gérmenes más frecuentes y modalidades ventilatorias empleadas. Resultados: predominaron los pacientes mayores de 60 años, para un 41 %, seguido por el grupo de 50 a 59 años con 26,5 %. El germen más frecuente fue el bacilo no fermentador para el 76,6 %; la modalidad ventilatoria de volumen control fue la más utilizada, en 75 pacientes (43,6 %; el trastorno hidromineral se presentó en el 41 % de los casos, todos con tendencia a la hipokaliemia, que dio lugar a un difícil destete; los síntomas radiológicos anatomoclínicos fueron los relacionados con las neumonías a focos diseminados con 95 pacientes para 54,9 %. Conclusiones: se logró caracterizar a los pacientes con neumonías bacterianas asociadas a la ventilación artificial mecánica.

  1. Identificación y clasificación en biotipos de las malezas asociadas con el cultivo de la palma de aceite

    OpenAIRE

    2012-01-01

    En dos plantaciones de palma de aceite, ubicadas en los municipios de Villanueva, Casanare, y Barranca de Upía, Meta, (Colombia), zona del Bajo Upía, se realizó un reconocimiento y clasificación en biotipos de las malezas asociadas con la palma de aceite. Para realizar el trabajo se visitaron las dos fincas, y se procedió a recoger muestras y fotografiar las malezas que se encontraban dentro del cultivo, así como en su contorno. La identificación y descripción se realizó siguiendo la metodolo...

  2. Identificación y clasificación en biotipos de las malezas asociadas con el cultivo de la palma de aceite

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Ariza

    2012-07-01

    Full Text Available En dos plantaciones de palma de aceite, ubicadas en los municipios de Villanueva, Casanare, y Barranca de Upía, Meta, (Colombia, zona del Bajo Upía, se realizó un reconocimiento y clasificación en biotipos de las malezas asociadas con la palma de aceite. Para realizar el trabajo se visitaron las dos fincas, y se procedió a recoger muestras y fotografiar las malezas que se encontraban dentro del cultivo, así como en su contorno. La identificación y descripción se realizó siguiendo la metodología binaria latina expuesta por Linneo y especificada en el Código Internacional de Nomenclatura Botánica, reportada para las especies reconocidas, mediante los servicios del herbario de la Universidad Pedagógica y Tecnológica de Colombia, y referencias de autores como Doll et al. (1972, Lemus y Lemus (2004, Rentería et al. (2006, Blair y Madrigal (2005, Fuentes et al. (1998, Kress et al. (2004, Becerra y Chaparro (1999 y Genty (1993. Para la agrupación de las malezas en biotipos (lianas, herbáceas, arbustos y árboles se tuvieron en cuenta sus características morfológicas. Se encontraron en  total 195 especies de malezas asociadas con el cultivo de la palma de aceite, 145 dicotiledóneas y 50 monocotiledóneas, pertenecientes a 43 familias.

  3. Massive vulval edema with severe preeclampsia. Case report Edema vulvar masivo con preeclampsia grave. Presentación de un caso.

    OpenAIRE

    José Luis Gómez Miranda.; José Luis Durán Páez; Nelson Pérez Rumbaut

    2009-01-01

    Massive vulval edema with severe preeclampsia is presented as one of the consequences that may appear on patients with hypertension disorders during pregnancy, therefore the attention in the Obstetrics and Gynecology Service must be systematical and permanent. On women with hypertensive disorders during pregnancy, although edemas may not be constant, they may either appear at minor, barely perceptible extents, or even in the most severe ways, such as anasarca. A very peculiar manifestation of...

  4. Factores asociados al desarrollo de preeclampsia en un hospital de Piura, Perú

    Directory of Open Access Journals (Sweden)

    Yamalí Benites-Condor

    2012-09-01

    Full Text Available Introducción: La Organización Mundial de la Salud indica que diariamente fallecen alrededor de 800 mujeres por causas relacionadas al embarazo y parto, dentro de las cuales la preeclampsia ocupa el tercer lugar. Objetivo: identificar los factores asociados a preeclampsia en gestantes que fueron hospitalizadas en el Hospital de Apoyo II “Santa Rosa” de la ciudad de Piura durante el periodo junio 2010 - mayo 2011. Métodos: Se realizó un estudio descriptivo retrospectivo de casos y controles, en gestantes hospitalizadas entre junio del 2010 y mayo del 2011. Mediante un muestreo aleatorio se obtuvieron 39 casos de preeclampsia y 78 controles sin preeclampsia. Los datos fueron analizados con el paquete estadístico SPSS v19.0, en el cual se ejecutó un análisis de casos y controles no pareados aplicando la prueba Chi cuadrado. Resultados: Fueron variables significativamente asociadas con la preeclampsia: Edad 35 años  (p=0,021, y número de controles prenatales mayor o igual a siete (p= 0,049. No resultaron significativos la primiparidad ni el sobrepeso. Interpretación: Se debe promover un control prenatal adecuado (traducido como siete o más controles durante la gestación, especialmente en aquellas mujeres que se encuentran en los extremos de la vida fértil.

  5. FACTORES ASOCIADOS AL DESARROLLO DE PREECLAMPSIA EN UN HOSPITAL DE PIURA, PERÚ

    Directory of Open Access Journals (Sweden)

    Yamalí Benites-Cóndor

    2011-01-01

    Full Text Available Introducción: La Organización Mundial de la Salud indica que diariamente fallecen alrededor de 800 mujeres por causas relacionadas al embarazo y parto, dentro de las cuales la preeclampsia ocupa el tercer lugar. Objetivo: identificar los factores asociados a preeclampsia en gestantes que fueron hospitalizadas en el Hospital de Apoyo II "Santa Rosa" de la ciudad de Piura durante el periodo junio 2010 - mayo 2011. Métodos: Se realizó un estudio descriptivo retrospectivo de casos y controles, en gestantes hospitalizadas entre junio del 2010 y mayo del 2011. Mediante un muestreo aleatorio se obtuvieron 39 casos de preeclampsia y 78 controles sin preeclampsia. Los datos fueron analizados con el paquete estadístico SPSS v19.0, en el cual se ejecutó un análisis de casos y controles no pareados aplicando la prueba Chi cuadrado. Resultados: Fueron variables significativamente asociadas con la preeclampsia: Edad 35 años (p=0,021, y número de controles prenatales mayor o igual a siete (p= 0,049. No resultaron significativos la primiparidad ni el sobrepeso. Interpretación: Se debe promover un control prenatal adecuado (traducido como siete o más controles durante la gestación, especialmente en aquellas mujeres que se encuentran en los extremos de la vida fértil.

  6. Análisis morfológico de escarpas asociadas a una falla de intraplaca con actividad cuaternaria: falla Las lagunas, Córdoba

    Directory of Open Access Journals (Sweden)

    Diego Villalba

    2014-03-01

    Full Text Available El objetivo de la presente contribución es, mediante el análisis cuantitativo de la morfología de escarpas de falla desarrolladas sobre sedimentos cuaternarios, estimar las edades de las reactivaciones prehistóricas e históricas de la falla Las Lagunas. El área de estudio se ubica al SO del departamento Río Cuarto, en el sector pedemontano de la sierra de Comechingones entre las localidades de Achiras y Sampacho, a 33° 18' S y 64° 49´ O, región central de Argentina. El análisis morfológico cuantitativo se realizó mediante la obtención de perfiles topográficos de detalle transversales a la traza de la estructura y la aplicación de curvas de regresión para determinar sus edades. Esto permitió interpretar que las evidencias de deformación mecánica, ruptura en superficie, corresponden a, al menos, cuatro fuertes terremotos asociados a esta falla con ocurrencia en los últimos 10 ka. Con esta información se elaboró una curva de aproximación característica para rupturas en superficie, asociadas a esta falla, de edades menores o iguales a 100 años.

  7. Concepciones teóricas de Neuman asociadas con la prevención de las úlceras por presión: un estudio de caso

    Directory of Open Access Journals (Sweden)

    Jairo Edielson Rodrigues Barbosa de Sousa

    2015-12-01

    Full Text Available Relato de caso que tiene como objetivo mostrar cómo el uso de la Teoría de Neuman asociada con la prevención de las úlceras por presión (UPP utilizando la Escala de Braden como estándar clínico, es eficaz para reducir la incidencia de UPP en la unidad de cuidados intensivos. Se presenta el caso de una anciana de 94 años, ingresada por insuficiencia respiratoria aguda, con diagnósticos asociados de neumonía y diabetes descompensada en la Unidad de Cuidados Intensivos (UCI de un hospital en Teresina, Piauí, Brasil. Durante los 64 días en que estuvo en la UCI, aunque que tuviera muchos factores de riesgo, no ha presentado ninguna UPP, mostrando cómo las medidas preventivas que fueron llevadas a cabo han sido eficaces para la prevención.

  8. Osteonecrosis de los maxilares asociada a denosumab en una paciente con osteoporosis: un caso clínico

    Directory of Open Access Journals (Sweden)

    Blas Garcia Garcia

    2015-07-01

    Full Text Available Desde la comercialización de fármacos que actúan sobre el remodelado óseo se han registrado numerosos casos de osteonecrosis de los maxilares (ONM, pero hasta hace poco solo se habían descrito casos de ONM asociados a la administración de bifosfonatos. Con la introducción de nuevos agentes antirresortivos han aparecido varios casos de ONM asociados a denosumab. Presentamos el caso de una paciente de 84 años con osteoporosis, que presentó osteonecrosis mandibular tras la colocación de 6 implantes 5 meses después de la administración de denosumab. Una ortopantomografía y una TC mostraron pérdida ósea de la cresta mandibular y exposición ósea periimplantar. Tras el tratamiento conservador con antibióticos y la suspensión de denosumab, se inició el tratamiento con teriparatida reduciéndose la infección del hueso necrótico y se observó nueva remodelación ósea. La patogénesis de la ONM por denosumab no está claramente definida, pero parece que la tasa del éxito de curación es superior a la ONM por bifosfonatos.

  9. Preeclampsia Research

    Science.gov (United States)

    ... Preeclampsia Research at the NICHD Skip sharing on social media links Share this: Page Content NICHD Research aims to detect, treat, and prevent this potentially dangerous condition of pregnancy Preeclampsia is a syndrome that occurs during pregnancy ...

  10. Estudio de un brote de bacteremia secundaria asociada con nutrición parenteral en una unidad de recién nacidos de tercer nivel.

    Directory of Open Access Journals (Sweden)

    Jaime A. del Río

    2009-10-01

    Full Text Available Ante la evidencia de un brote de bacteremia secundaria neonatal, en la Unidad de Recién Nacidos, Hospital de Caldas, Manizales, se realizó un estudio de casos y controles 1:4, para determinar la asociación de factores de riesgo importantes para los pediatras como nutrición parenteral, terapia respiratoria, tubo orotraqueal, cámara cefálica, parto vaginal, la aplicación de hemoderivado, remisión de otra unidad, leche materna por sonda, peso y edad. Como definición de caso se adoptó la clínica con por lo menos dos hemocultivos positivos, patógeno de piel hemocultivado y germen aislado en sangre sin foco definido. Los 19 controles se tomaron al azar de los recién nacidos que se encontraban hospitalizados por otras causas diferentes o relacionadas con la patología. Se realizó una regresión logística paso a paso, para determinar los eventos causales. Los gérmenes hemocultivados fueron Escherichia coli, Enterobacter gergoviae, E. aerogenes y E. cloacae. La edad promedio de los casos fue 30.6 semanas, en los controles 36.6 meses (p 0.2 NS. Peso promedio de los casos 1,385 g contra 2,621 g en los controles. Se encontró asociada la nutrición parenteral con el brote OR=15 (IC=1-482 p 0.027 S. Otros factores como la edad y el peso fueron de confusión. En cuanto a la nutrición parenteral, se corroboró su implicación, porque al revisar de inmediato el proceso de nutrición parenteral se encontró que los productos sobrantes se estaban almacenando y reutilizando hasta por 30 días.

  11. Caracterización de las mutaciones en el gen rpoβ asociadas a la rifampicina en pacientes con tuberculosis pulmonar

    Directory of Open Access Journals (Sweden)

    Juan Agapito

    2002-07-01

    Full Text Available Antecedentes: La resistencia a rifampicina en M. tuberculosis involucra mutaciones en el gen rpoβ que codifica a la subunidad β de la ARN polimerasa. Objetivo: Identificar las mutaciones del gen rpoβ , en cepas de M. tuberculosis asociadas con resistencia a rifampicina aisladas de la Subregiσn de Salud Lima Norte, Perϊ. Materiales y métodos: Se cultivó en Lowestein - Jenseen 73 muestras de esputo de pacientes con tuberculosis pulmonar. A 62, con más de 10 colonias por tubo, se les comprobó susceptibilidad a isoniazida, rifampicina, estreptomicina y etambutol. Se realizó la extracción de ADN por PCR, clonación en el vector pGEM-T, transformación, selección de clonas recombinantes y secuenciamiento del ADN plasmídico para la determinación de los polimorfismos del gen rpoβ. Resultados: 52 (83,9% cepas fueron resistentes a rifampicina (Rif r y 10 (16,1% susceptibles (Rif s . Se encontró alteraciones en el gen rpoβ en 51 de 52 cepas Rif r Se identificaron 20 mutaciones. Las mutaciones mαs frecuentes fueron encontradas en los codones Ser-531 (62,7%, His-526 (15,7%, Asp-516 (11,8% y Gln-513 (5,9%. No se observσ mutaciσn alguna en las 10 cepas Rif s. 94,2% de nuestras cepas Rif r fueron también resistentes a isoniazida. Conclusiones: Se encontraron mutaciones en el gen rpoB de casi todas las cepas Rif r ; asimismo, casi todas las cepas Rif r fueron también resistentes a isoniazida.

  12. Nutritional assessment associated with length of inpatients' hospital stay Evaluación nutricional asociada con la estancia hospitalaria

    Directory of Open Access Journals (Sweden)

    H. G. Valente da Silva

    2012-04-01

    Full Text Available Objective: To evaluate the nutritional status of patients on hospital admission, identify the length of hospital stay and identify the parameters of nutritional assessment that are most closely related with the length of stay (LOS. Methods: A cross-sectional study of 278 hospitalized patients evaluated patients´ nutritional status in the 48 hours after admission and their LOS after discharge. Anthropometric and biochemical parameters, related to nutrition status were analyzed, such as: weight, height, arm circumference (AC, waist circumference (WC, triceps skinfold thickness (TST, mild arm muscle circumference (MAMC, albumin (Alb and hemoglobin (HB. Body mass index (BMI was used to classify the nutritional status. All the nutritional factors except type of disease, gender and age were associated with LOS. The chi-square, Student-t, Mann-Whitney, Kruskal-Wallis and binary logistic multivariate tests were used in the statistical analyses. Results: The majority of patients was male (53%, elderly (56% and had neoplasm (19.4%. Undernutrition was higher in the elderly (p Objetivo: Evaluar el estado nutricional de los pacientes ingresados en el hospital, identificar la duración de la estancia hospitalaria e identificar los parámetros de la evaluación nutricional que se relacionen más estrechamente con la duración de la estancia (DE. Métodos: Se evaluó en un estudio transversal con 278 pacientes hospitalizados el estado nutricional en las 48 horas siguientes al ingreso y su DE tras el alta. Se analizaron los parámetros antropométricos y bioquímicos en relación con el estado nutricional, tales como: peso, talla, circunferencia del brazo (CB, circunferencia de la cintura (CC, el grosor del pliegue cutáneo tricipital (GPT, la circunferencia de la musculatura del brazo (CMB, la albúmina (Alb y la hemoglobina (HB. Se empleó el índice de masa corporal (IMC para clasificar el estado nutricional. Todos los factores nutricionales salvo el tipo de

  13. Variables psicosociales asociadas con el grado de aceptación de la orientación sexual no heterosexual

    Directory of Open Access Journals (Sweden)

    Elvia Vargas-Trujillo

    2003-01-01

    Full Text Available Se analizó el grado de aceptación de la orientación sexual no-heterosexual de un grupo de jóvenes bogotanos y su relación con algunas variables psicosociales. Se conformó una muestra de conveniencia de 88 jóvenes no heterosexuales (60 hombres y 28 mujeres, entre los 18 y los 25 años de edad, de estratos 3, 4, 5 y 6. Se utilizó un cuestionario de autoreporte diseñado para este estudio. Se encontró que el grado de aceptación de la orientación sexual se puede predecir a partir de la homofobia internalizada. Los resultados corroboran los hallazgos de investigaciones realizadas en otros países sobre la asociación positiva significativa del grado de aceptación de la orientación no heterosexual con la autoestima y la percepción de apoyo social.

  14. [Relationship between dyslipidemia and severity in preeclampsia].

    Science.gov (United States)

    Duarte-Mote, Jesús; Perez-Torres, Carolina; Espinosa-López, Rogelio; Eng-Castro, Víctor Lee; Calvo-Colindres, Jesús; Sánchez-Rojas, Graciela; Romero-Figueroa, Maria del Socorro

    2014-01-01

    Introducción: se ha identificado que los valores del colesterol y los triglicéridos (TG) son más altos en la preeclampsia que en el embarazo normal; sin embargo, aún no está claro si estos niveles tienen relación con la gravedad del proceso. El objetivo del estudio fue determinar si existe relación entre la dislipidemia y la gravedad en la preeclampsia. Métodos: estudio transversal comparativo en 200 pacientes, 100 con embarazo normal y 100 con preeclampsia. Se identificó edad, antecedentes ginecoobstétricos, colesterol total y TG. Se utilizó estadística descriptiva: t de Student para comparar el grupo de pacientes con preeclampsia y embarazos normales, y ANOVA y razón de momios para el subanálisis de preeclampsia leve y severa. Resultados: no se encontraron diferencias estadísticamente significativas en edad, ni en colesterol. Los TG presentaron una diferencia estadísticamente significativa: fueron más altos en relación con la gravedad de la preeclampsia (embarazo normal 245 mg, preeclampsia leve 308 mg y preeclampsia severa 349 mg). Conclusión: los niveles elevados de colesterol y TG en pacientes con preeclampsia no demostraron consistencia en relación con la gravedad de la preeclampsia.

  15. Condiciones locales de vulnerabilidad asociadas con dengue en dos comunidades de Morelos Local conditions of vulnerability associated with dengue in two communities of Morelos

    Directory of Open Access Journals (Sweden)

    Silvia Chuc

    2013-04-01

    Full Text Available OBJETIVO: Evaluar las condiciones de vulnerabilidad asociadas con la ocurrencia de dengue en dos localidades de Morelos en los años 2006 a 2009. MATERIAL Y MÉTODOS: se aplicó una encuesta sobre conocimientos, percepción de riesgo, prácticas de prevención y uso del agua en dos localidades de Morelos. Mediante un análisis de componentes principales, se construyó un índice de vulnerabilidad local al dengue (IVL. La asociación del IVL con la enfermedad en la vivienda se evaluó mediante una prueba de ji cuadrada. RESULTADOS: El IVL incluyó cinco componentes explicando el 63% de la varianza y fue clasificado en tres categorías: baja, media y alta. Se observó una asociación significativa entre el aumento de la vulnerabilidad y la prevalencia del reporte de casos de dengue en las localidades. CONCLUSIÓN: El estudio de la vulnerabilidad al dengue permite identificar necesidades locales específicas en materia de promoción de la salud.OBJECTIVE: To evaluate the vulnerability associated with the occurrence of dengue in two villages of Morelos, Mexico from 2006 to 2009. MATERIALS AND METHODS. A survey on knowledge, risk perception, prevention practices and water use was applied in two villages of Morelos. Using a principal component analysis, an index of local vulnerability to dengue (IVL was constructed. The association of IVL with the disease at home was assessed using a Chi-square test. RESULTS: The IVL included five components explaining 63% of the variance and was classified in three categories: low, medium and high. There was a significant association between increased vulnerability and prevalence of reported cases of dengue in Temixco and Tlaquiltenango. CONCLUSION: The study of vulnerability to dengue allows us to identify local needs in the field of health promotion.

  16. Comportamiento gráfico de la presión arterial diastólica durante el embarazo en gestantes con riesgo de preeclampsia.

    OpenAIRE

    Julián A. Herrera; Carlos H. Moreno

    2009-01-01

    Se realizó un estudio prospectivo incluyendo 3,670 gestantes sanas de bajo nivel socioeconómico en control prenatal en 132 centros de salud y hospitales de empresas sociales del Estado en siete departamentos del occidente de Colombia. El objetivo del estudio fue evaluar el comportamiento gráfico de la presión arterial diastólica (PAD) en el embarazo de pacientes que desarrollaban preeclampsia. Se establecieron los percentiles de PAD por cada semana de edad gestacional con respecto a la presen...

  17. Biomarcadores del estado inflamatorio: nexo de unión con la obesidad y complicaciones asociadas Inflammatory biomarkers: the link between obesity and associated pathologies

    Directory of Open Access Journals (Sweden)

    M.ª A. Zulet

    2007-10-01

    Full Text Available El objetivo de este trabajo ha consistido en realizar una revisión de los biomarcadores que actualmente se proponen como el nexo de unión entre la inflamación, la obesidad y complicaciones asociadas, seleccionando los estudios llevados a cabo y las cuestiones pendientes. Cada vez hay mayor evidencia científica de que la inflamación puede jugar un papel importante en la etiología de diversas enfermedades crónicas de gran relevancia para la salud pública. En los últimos años, distintos estudios han sugerido que la obesidad podría ser un desorden inflamatorio. Asimismo, el estrés oxidativo se ha propuesto como un potencial inductor de la inflamación y de la susceptibilidad a la obesidad y patología asociadas. Entre los biomarcadores relacionados con la obesidad, la resistencia insulínica, las enfermedades cardiovasculares y el síndrome metabólico se encuentran: el factor de necrosis tumoral alfa, interleuquinas 6 y 18, angiotensinógeno, factor de crecimiento TGF-beta, inhibidor de la activación del plasminógeno, leptina, resistina, proteína C reactiva, amiloide A, ácido siálico, marcadores de disfunción endotelial (factor von Willebrand, ICAMs, vCAMs factor 3 del sistema del complemento, haptoglobina, glicoproteína zinc-alfa2, eotaxina, visfatina, apelina, alfa1-antitripsina, vaspina, omentina, proteína transportadora de retinol 4, ceruloplasmina, adiponectina y desnutrina. Algunos de estos biomarcadores son buenos predictores de riesgo cardiovascular (inhibidor de la activación de plasminógeno 1, angiotensinógeno, fibrinógeno, ácido siálico, factor 3 del complemento y proteína C reactiva, adiposidad (leptina, visfatina, resistina, haptoglobina y/o resistencia insulínica (ácido siálico, proteína C reactiva, inhibidor de la activación de plasminógeno 1, factor von Willebrand. Sin embargo, todavía queda por dilucidar el papel de muchos de ellos en la etiología de la obesidad y comorbilidades asociadas en

  18. Características asociadas al riesgo de suicidio evaluado clínicamente en personas con intento reciente

    Directory of Open Access Journals (Sweden)

    Diana Restrepo

    2008-02-01

    Full Text Available

    OBJETIVOS: en un grupo de individuos que ingresaron por intento de suicidio a los servicios de urgencias de diferentes centros asistenciales de la ciudad de Medellín, se describen las características de aquellos clasificados en la evaluación clínica psiquiátrica como de alto o bajo riesgo de reincidencia.

    MÉTODOS: es un estudio de corte transversal. Se hizo entrevista psiquiátrica a 238 individuos con intento de suicidio reciente para clasificarlos en dos grupos, de alto o bajo riesgo de reincidencia, y se aplicó el instrumento de autorreporte “Inventario de Razones para Vivir” (RFL. Posteriormente, se compararon las características de ambos grupos.

    RESULTADOS: el 60,5% de los participantes se consideraron de alto riesgo de suicidio y los factores que se encontraron asociados fueron: trastorno depresivo mayor (OR = 5,78; IC 95%: 3,01-11,2, método violento (OR = 5,21; IC 95%: 1,89-14,37, intoxicación por sustancias psicoactivas durante el intento (OR = 2,46; IC 95%: 1,07-5,64 y puntaje bajo en el “Inventario de Razones para Vivir” (OR = 0,47; IC 95%: 0,34-0,66

    CONCLUSIONES: aunque los resultados no son generalizables, son similares a los encontrados en otros lugares. Es necesario hacer estudios longitudinales que permitan determinar la utilidad de estas características para predecir conductas suicidas.

  19. Preeclampsia 2012

    Directory of Open Access Journals (Sweden)

    Elosha Eiland

    2012-01-01

    Full Text Available Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options.

  20. Preeclampsia como factor de riesgo independiente para el trastorno por déficit de atención con hiperactividad. Estudio de casos y controles. Bucaramanga, Colombia

    Directory of Open Access Journals (Sweden)

    Yuly Andrea Castellanos-Castellanos

    2014-07-01

    Full Text Available Introducción: El trastorno por déficit de atención e hiperactividad es una condición mental que afecta a niños y adolescentes con prevalencia estimada de 5.3% en la población mundial y en Colombia es de 19-24% en hombres y 10-12% en mujeres. Su etiología es multifactorial, entre ellos se encuentra la hipoxia como factor del medio ambiente uterino; presentándose en entidades como la preeclampsia, donde se ha considerado determinante en el desarrollo del trastorno por déficit de atención e hiperactividad, siendo importante evaluar su asociación. Objetivo: Determinar la asociación entre el diagnóstico trastorno por déficit de atención e hiperactividad y el antecedente perinatal de preeclampsia. Metodología: Estudio de casos y controles retrospectivo de 411 casos de trastorno por déficit de atención e hiperactividad y 404 controles no emparentados sin trastorno ni otros trastornos disruptivos del comportamiento. La evaluación psiquiátrica se hizo entre el 2005–2011, mediante entrevista estructurada que incluyó indagar el antecedente de preeclamsia en el embarazo de cada paciente. Resultados: El antecedente de preeclampsia se presentó en el 3.7% de los pacientes con trastorno por déficit de atención e hiperactividad y en el 5.5% de los controles (OR 0.66, IC95% 0.34 – 1.29; p=0.221. Esta falta de asociación se mantuvo luego de ajustar por género, ser adoptado, haber nacido por cesárea y edad de inicio del trastorno que llevó a consultar al paciente (OR 0.51, IC95% 0.22 – 1.17; p=0.115. Conclusión: El estudio no encontró significancia estadística entre el antecedente de preeclampsia materna y el trastorno por déficit de atención e hiperactividad como factor principalmente asociado en la muestra de pacientes seleccionados.

  1. Análisis relacional de las contingencias asociadas a las prácticas deportivas con los trastornos de alimentación en adolescentes entre los 16 a 18 años

    OpenAIRE

    Marcela Noreña Mejía; Natalia Rojas Segura; Mónica María Novoa Gómez

    2006-01-01

    Este estudio analizó las contingencias asociadas a las prácticas deportivas y su relación con trastornos de alimentación en 42 mujeres adolescentes entre los 16 y 18 años de Bogotá, asignadas intencionalmente en tres grupos: Grupo A, adolescentes que pertenecen a un equipo deportivo; Grupo B, adolescentes que practican deporte con regularidad y Grupo C, adolescentes que no practican deporte, salvo la clase de educación física. El marco explicativo que sustenta la investigación se deriva del a...

  2. Hyperinfection by Strongyloides stercoralis probably associated with Rituximab in a patient with mantle cell lymphoma and hyper eosinophilia Hiperinfección por Strongyloides stercoralis probablemente asociada con Rituximab en una paciente con linfoma e hipereosinofilia

    Directory of Open Access Journals (Sweden)

    Renzo Nino Incani

    2010-08-01

    Full Text Available The first report to our knowledge, of hyperinfection by Strongyloides stercoralis (HS and hypereosinophilia, associated to immune suppression by Rituximab (the only drug received for the last one year and 10 months, in a patient with mantle-cell lymphoma (MCL, is presented. The patient has a 3-year history of MCL, and developed two accesses of HS during 2008, including meningitis, pneumonia and presence of larvae of S. stercoralis in the lungs. We had a unique chance to look at cytotoxicity of filariform larvae in the expectoration after Ivermectin treatment, showing immobilization and death of larvae, associated with eosinophils attached to the cuticle of the parasite.Se presenta el primer reporte, hasta donde tengamos información, de hiperinfección por Strongyloides stercoralis (HS e hipereosinofilia asociados a inmunosupresión por Rituximab (el único medicamento recibido durante 1 año y 10 meses, en un paciente con linfoma de células del manto (LCM. La paciente tuvo una historia de 3 años con LCM, y desarrolló 2 accesos de HS durante el 2008, incluyendo meningitis, neumonía y presencia de larvas de S. stercoralis en los pulmones. Se tuvo la oportunidad única de observar la citotoxicidad contra las larvas filariformes en la expectoración, luego del tratamiento con Ivermectina, mostrando la inmovilización y muerte de las larvas, asociada a la presencia de eosinófilos adheridos a la cutícula del parásito.

  3. Comportamiento gráfico de la presión arterial diastólica durante el embarazo en gestantes con riesgo de preeclampsia.

    Directory of Open Access Journals (Sweden)

    Julián A. Herrera

    2009-10-01

    Full Text Available Se realizó un estudio prospectivo incluyendo 3,670 gestantes sanas de bajo nivel socioeconómico en control prenatal en 132 centros de salud y hospitales de empresas sociales del Estado en siete departamentos del occidente de Colombia. El objetivo del estudio fue evaluar el comportamiento gráfico de la presión arterial diastólica (PAD en el embarazo de pacientes que desarrollaban preeclampsia. Se establecieron los percentiles de PAD por cada semana de edad gestacional con respecto a la presentación o no de la enfermedad. Con la técnica exploratoria de datos se delimitó una zona de bajo y alto riesgo en el seguimiento gráfico de la PAD con respecto al desarrollo de la enfermedad. La edad promedio de las gestantes fue 24 años, 1080 (29.4 % eran primigrávidas, 620 (16.9% de raza negra, 161 (4.4% de raza indígena, y 198 (5.4% adolescentes menores de 16 años. En 313 (8.5% gestantes hubo preeclampsia con un promedio de presión arterial diastólica en el transcurso del embarazo de 77.8 ± 12.1 comparada con 69.1 ± 9.9 en quienes no la desarrollaron (p< 0.01. El no mantener el descenso fisiológico de la PAD en el segundo trimestre , observado gráficamente como un progreso de una zona de bajo a alto riesgo se presentó en 24.5% de las gestantes que desarrollaron la enfermedad comparado con 6% de gestantes que mantuvieron el descenso fisiológico y desarrollaron la enfermedad (p< 0.01. Los resultados de este estudio demostraron que el comportamiento gráfico de la PAD anormal descubierto con el no mantenimiento del descenso fisiológico en el segundo trimestre del embarazo puede alertar al equipo de salud sobre el riesgo de la enfermedad.

  4. Infección natural de chinches Triatominae con Trypanosoma cruzi asociadas a la vivienda humana en México Natural infection of Triatominae bugs in Mexican dwellings

    Directory of Open Access Journals (Sweden)

    Vianey Vidal-Acosta

    2000-11-01

    Full Text Available OBJETIVO: Informar el porcentaje de infección natural de las especies de triatóminos que habitan con mayor frecuencia el medio doméstico y peridoméstico en México, así como dar a conocer las localidades de colecta por estado. MATERIAL Y MÉTODOS: Se recibieron muestras de chinches Triatominae en el Departamento de Entomología del Instituto de Diagnóstico y Referencia Epidemiológicos, para su determinación taxonómica y la búsqueda parasitoscópica de Trypanosoma cruzi, provenientes de 14 estados del país, de enero de 1993 a diciembre de 1999. Se analizaron en conjunto los resultados obtenidos en esos años. RESULTADOS: De una muestra de 5 399 ejemplares, fueron 13 las especies de triatóminos asociadas a las viviendas. El porcentaje de infección natural tuvo una amplia variación entre las especies. De las estudiadas, nueve se encontraron con infección natural; el mayor porcentaje de infección corresponde a Triatoma pallidipennis, T. picturata, Rhodnius prolixus y T. longipennis. Los estados con mayor porcentaje de infección fueron Nayarit, Morelos y Michoacán. Se presentaron nuevos registros estatales de Triatoma dimidiata, T. gerstaeckeri, T. longipennis, T. mexicana y T. pallidipennis y uno local de Pastrongylus rufotuberculatus. Además, se informa por primera vez la infección natural en algunas de ellas. CONCLUSIONES: Se debe poner mayor énfasis en el estudio de la biología y aspectos bionómicos de los triatóminos y realizar una vigilancia permanente para tener los registros de distribución actualizados, así como para conocer los índices de infección natural por T. cruzi, de las especies domiciliarias, peridomiciliarias y de las que están en proceso de adaptación a la vivienda humana.OBJECTIVE: To estimate the prevalence of infection with Trypanosoma cruzi in Triatominae species frequently found in and around Mexican dwellings, and to assess the frequency of Triatominae in towns by state. MATERIAL AND METHODS

  5. Anestesia conductiva en cesáreas de gestantes con preeclampsia severa previa estabilización hemodinámica en el Hospital Gineco-Obstétrico "Enrique C. Sotomayor" período 2014. Propuesta de norma.

    OpenAIRE

    Castro Coello, Hamilton Michael

    2015-01-01

    Los trastornos hipertensivos en las gestantes son causa importante de morbilidad, discapacidad crónica y muerte entre las madres, los fetos y los recién nacidos; entre estos, la preeclampsia. Objetivo: Evaluar la anestesia conductiva en cesáreas de gestantes con preeclampsia severa previa estabilización hemodinámica en el hospital gineco-obstétrico "Enrique C. Sotomayor" período 2014. Materiales y métodos: Se elaboró un estudio observacional y prospectivo de una serie de casos de la muestra s...

  6. Pregnancy Complications: Preeclampsia

    Science.gov (United States)

    ... Close X Home > Complications & Loss > Pregnancy complications > Preeclampsia Preeclampsia E-mail to a friend Please fill in ... even if you’re feeling fine. What is preeclampsia? Preeclampsia is a condition that can happen after ...

  7. Preeclampsia 2012

    OpenAIRE

    2012-01-01

    Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclea...

  8. COMPOSICIÓN QUIMICA DE LA LECHE, DIGESTIBILIDAD in vitro DE LA MATERIA SECA Y PRODUCCIÓN EN VACAS ALIMENTADAS CON GRAMÍNEAS SOLAS O ASOCIADAS CON Lotus uliginosus

    Directory of Open Access Journals (Sweden)

    A. Morales

    2013-01-01

    Full Text Available La presente investigación tuvo como objetivo evaluar el uso de la leguminosa Lotus uliginosus como alternativa de inclusión dentro de las praderas en dos ecorregiones estratégicas de la sabana de Bogotá. en cada finca se evaluaron cuatro tratamientos: 1 kikuyo solo (P. clandestinum, 2 kikuyo asociado con trébol pata de pájaro ( P.clandes-tinum + L. uliginosus, 3 festuca alta sola (F. arundinacea y 4 Festuca alta asociada con trébol pata de pájaro (F. arundinacea + L. uliginosus. el número de bovinos varió de acuerdo a la capacidad de carga de cada finca. se utilizaron animales que se encontraban en el segundo tercio de lactancia durante un período experimental de siete días. en cada tratamiento se determinó la producción (L/día y calidad de leche (% de grasa, proteína y sólidos totales; en la pastura se evaluó la composición química (Ms, Fdn, Fda y la digestibilidad in vitro de la materia seca (divMs. se midió el consumo voluntario. en la finca Megaleche la producción de biomasa presentó diferencias significativas (P<0,05 entre los tratamientos destacándose el tratamiento del kikuyo solo; la calidad nutricional de las pasturas también presentó diferencias (P<0,04 destacándose el tratamiento de kikuyo + trébol pata de pájaro, asociación que también se destacó en consumo voluntario (P< 0.05 y producción de leche (P<0,05. en la finca Colega el contenido de proteína del forraje presentó diferencias cuando las gramíneas se asociaron con el trébol pata de pájaro (P<0,001. se concluyó que la introducción del Lotus en las praderas mejoró la producción de leche y consumo de materia seca en los animales.

  9. Inmunodetección de metaloproteinasas de matriz extracelular (MMPs)-2, -9, -13 y -14 en lesiones apicales asociadas con periodontitis apical asintomática

    OpenAIRE

    2011-01-01

    La periodontitis apical asintomática (PAa) es una patología infecciosa caracterizada por destrucción ósea perirradicular asociada a un proceso inflamatorio crónico y producción de mediadores inflamatorios, entre los cuales se encuentran las metaloproteinasas de matriz extracelular (MMPs). Entre éstas, las MMPs-13, -14, -2 y -9, son producidas por el tejido óseo y degradan sinérgicamente el colágeno tipo I, principal componente de los tejidos periodontales, y gelatina, producto de la degradaci...

  10. Biomarcadores del estado inflamatorio: nexo de unión con la obesidad y complicaciones asociadas Inflammatory biomarkers: the link between obesity and associated pathologies

    OpenAIRE

    M.ª A Zulet; B. Puchau; Navarro, C.; Martí, A.; J.A. Martínez

    2007-01-01

    El objetivo de este trabajo ha consistido en realizar una revisión de los biomarcadores que actualmente se proponen como el nexo de unión entre la inflamación, la obesidad y complicaciones asociadas, seleccionando los estudios llevados a cabo y las cuestiones pendientes. Cada vez hay mayor evidencia científica de que la inflamación puede jugar un papel importante en la etiología de diversas enfermedades crónicas de gran relevancia para la salud pública. En los últimos años, distintos estudios...

  11. Hemorragias intracraneales de carácter evitable asociadas a anticoagulantes orales en pacientes con fibrilación auricular Avoidable intracranial hemorrhages associated with oral anticoagulants in patients with atrial fibrillation

    Directory of Open Access Journals (Sweden)

    A. García Luque

    2011-12-01

    Full Text Available Introducción y objetivo: El aumento de la prescripción de anticoagulantes orales ha provocado un aumento de hemorragias intracraneales, la reacción adversa más grave asociada a este grupo farmacológico. El objetivo del estudio es evaluar el carácter evitable de hemorragias intracraneales asociada a anticoagulantes orales que causan ingreso hospitalario en pacientes con fibrilación auricular. Método: Supervisión de las historias clínicas de los pacientes que ingresaron en los Hospitales Universitarios Virgen del Rocío (01/01/03 al 31/03/07 con hemorragia intracraneal y fibrilación auricular; considerando hemorragia intracraneal asociada a anticoagulantes orales aquellas con una relación ≥ posible al aplicar el algoritmo de causalidad del Sistema Español de Farmacovigilancia. Para valorar el carácter evitable de la hemorragia intracraneal se ha estudiado la relación beneficio/riesgo del uso de anticoagulantes orales. Resultados: Al menos 20/57 (35,1% hemorragias intracraneales asociadas a anticoagulantes orales pudieron ser potencialmente evitables, de las cuales en 7/20 (35% el desenlace fue mortal, presentando secuelas 8/13 (61,5% de los supervivientes. El fármaco sospechoso de interaccionar con anticoagulantes orales referenciado con mayor frecuencia fue el omeprazol, 11/57 (19%, a pesar de estar documentada esta interacción como altamente probable en la Bibliografía y en los protocolos del Hospital. Conclusiones: La relación beneficio/riesgo del uso de anticoagulantes orales, el control estricto del Índice Normalizado Internacional, junto con las posibles interacciones medicamentosas deben ser evaluadas de forma individualizada y periódicamente para minimizar el riesgo de hemorragia intracraneal, que en un porcentaje elevado de casos es una reacción adversa potencialmente evitable y mortal.Introduction and objectives: The increase in oral anticoagulants prescription has caused an increase in intracranial hemorrhages

  12. Síndrome HELLP: una forma de manifestación dela preeclampsia

    Directory of Open Access Journals (Sweden)

    Luis F. Restrepo

    1989-01-01

    Full Text Available

    Se presenta una paciente del Servicio de Obstetricia y Ginecología del Hospital Universitario San Vicente de Paúl de Medellín (HUSVP, que presentó preeclampsia asociada a manifestaciones hematológicas y hepáticas compatibles con el síndrome HELLP, recientemente descrito; tal síndrome consta de hemólisis, alteraciones de la función hepática y recuento plaquetario bajo. La paciente evolucionó satisfactoriamente; con base en su historia se hacen algunas consideraciones acerca del síndrome HELLP.

  13. Molecular Mechanisms of Preeclampsia

    OpenAIRE

    N. Vitoratos; D. Hassiakos; Iavazzo, C.

    2012-01-01

    Preeclampsia is one of the leading causes of maternal morbidity/mortality. The pathogenesis of preeclampsia is still under investigation. The aim of this paper is to present the molecular mechanisms implicating in the pathway leading to preeclampsia.

  14. Genetics Home Reference: preeclampsia

    Science.gov (United States)

    ... Help Me Understand Genetics Home Health Conditions preeclampsia preeclampsia Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description Preeclampsia is a complication of pregnancy in which affected ...

  15. Preeclampsia and Eclampsia

    Science.gov (United States)

    ... NICHD Research Information Clinical Trials Resources and Publications Preeclampsia and Eclampsia: Condition Information Skip sharing on social media links Share this: Page Content What are preeclampsia and eclampsia? Preeclampsia and eclampsia are part of ...

  16. Toxicidad sistémica asociada con la inyección intramuscular de mercurio metálico: reporte de un caso

    Directory of Open Access Journals (Sweden)

    Diego Mauricio González Ramírez

    2008-12-01

    Full Text Available Los reportes de toxicidad relacionados con mercurio metálico están dados fundamentalmente por inhalación de vapores con compromiso renal importante. Existen pocos casos reportados de toxicidad relacionada con la inyección subcutánea, muscular o venosa de éste metal. El espectro de manifestaciones es variado comprometiendo fundamentalmente los sistemas renal, endocrino y neurológico. Reportamos un caso de toxicidad sistémica secundaria a la inyección de mercurio metálico quien no recibió inicialmente manejo con quelantes presentando en su evolución disfunción renal, hiperparatiroidismo y osteoporosis secundaria con fractura patológica de cadera.

  17. [Atypical presentation of preeclampsia].

    Science.gov (United States)

    Ditisheim, A; Boulvain, M; Irion, O; Pechère-Bertschi, A

    2015-09-09

    Preeclampsia is a pregnancy-related syndrome, which still represents one of the major causes of maternal-fetal mortality and morbidity. Diagnosis can be made difficult due to the complexity of the disorder and its wide spectrum of clinical manifestations. In order to provide an efficient diagnostic tool to the clinician, medical societies regularly rethink the definition criteria. However, there are still clinical presentations of preeclampsia that escape the frame of the definition. The present review will address atypical forms of preeclampsia, such as preeclampsia without proteinuria, normotensive preeclampsia, preeclampsia before 20 weeks of gestation and post-partum preeclampsia.

  18. Hemorragias intracraneales asociadas a fármacos en pacientes con fibrilación auricular no reumática

    OpenAIRE

    García Luque, Amelia

    2008-01-01

    Numerosos ensayos clínicos aleatorizados (ECA) han demostrado el beneficio del uso de antirobóticos, fundamentalmente anticoagulantes orales (ACO), para la profilaxis de accidentes cerebrovascualres (ACV) isquémicos entre los pacientes con fibrilación auricular no reumática (FANR), siendo recomendado su uso por la mayoría de guías de práctica clínica (GPC), lo cual ha provocado un aumento del consumo de este grupo farmacológico. La prevalencia de fibrilación auricular (FA) aumenta con la eda...

  19. FRECUENCIA DE HIPERTENSIÓN ARTERIAL SISTÉMICA EN PERROS CON SOBREPESO U OBESIDAD Y SUS PATOLOGÍAS ASOCIADAS

    OpenAIRE

    Pérez Sánchez, Alicia Pamela

    2014-01-01

    La obesidad es una enfermedad relacionada con diferentes alteraciones metabólicas como la dislipidemia (hipercolesterolemia e hipertrigliceridemia), resistencia a la insulina e hipertensión arterial sistémica (HTA). El humano con obesidad y la presencia de dos de estas alteraciones, es denominado como un caso de síndrome metabólico (SM) en el que cobra interés el mecanismo fisiopatológico del proceso obesidad-hipertensión. En medicina veterinaria estas alteraciones metabólicas ...

  20. PARTICIPACION DE LA PROTEINA ERP57 EN LA BIOGENESIS DE LA PROTEINA PRION NORMAL Y MUTANTES ASOCIADAS A LAS ENFERMEDADES RELACIONADAS CON PRIONES

    OpenAIRE

    2013-01-01

    Los desórdenes relacionados con priones (DRP) son enfermedades neurodegenerativas fatales de progresión rápida con características neuropatológicas comunes, como la espongiosis, astrogliosis y una masiva pérdida neuronal. El evento clave a nivel molecular en estas enfermedades es la acumulación de una forma mal plegada y parcialmente resistente a proteasas de la proteína prion celular (PrPC), conocida como PrPRES. Los DRP pueden tener un origen infeccioso, esporádico o genético. Todos los ...

  1. Safety and efficacy of large balloon sphincteroplasty in a third care hospital Dilatación con balón asociada a esfinterotomía, evaluación de eficacia y seguridad en un hospital terciario

    Directory of Open Access Journals (Sweden)

    Eduardo Martín-Arranz

    2012-07-01

    Full Text Available Background and aims: large balloon sphincteroplasty (LBS associated with sphincterotomy (ES has gained acceptance as a useful tool in extracting difficult bile duct stones. Our purpose was to evaluate the efficacy and safety of LBS with balloons ≥ 10 mm in clinical practice setting. Patients and methods: unicentre prospective study in a tertiary care hospital. All patients who underwent LBS associated with ES between July 2007 and March 2011 were included prospectively in a database recording clinical aspects, procedure data, outcome and complications. Success is the main outcome defined as complete stone removal documented by absence of any filling defect during a final occlusion cholangiogram and absence of clinical or radiological findings after the ERCP consistent with remaining stones. Complications as pancreatitis, cholangitis, post-ERCP bleeding, perforation and others were also measured. Results: one hundred twenty procedures were made in 109 patients with balloons ranging from 10 to 20 mm. Success rate was 91% in the first attempt and 96.7% after two procedures. Mechanical lithotripsy was only needed in one case (0.8%. Complication rate was 4.2% due to five cases of post-ERCP bleeding in high risk patients. Conclusion: large balloon sphincteroplasty associated to sphincterotomy in clinical practice is a very effective and safe technique.Introducción y objetivos: la dilatación con balón de gran tamaño asociada a esfinterotomía es un recurso cada vez más utilizado en la extracción de coledocolitiasis de gran tamaño. El objetivo de este estudio es evaluar la eficacia y seguridad de la dilatación con balones mayores de 10 mm en un entorno de práctica clínica habitual. Pacientes y métodos: estudio prospectivo en un hospital terciario. Todos los pacientes en los que se realizó dilatación con balón mayor de 10 mm asociado a esfinterotomía entre julio de 2007 y marzo de 2011 se incluyeron prospectivamente en una base de datos

  2. Hemicorea asociada a toxoplasmosis cerebral y SIDA

    Directory of Open Access Journals (Sweden)

    N.S. garretto

    1995-03-01

    Full Text Available Se observan complicaciones neurológicas en 40% de enfermos con SIDA. De estos, en 10% puede ser la manifestation inicial de la enfermedad. En otro 11% pueden aparecer trastornos del movimiento. Comunicamos el primer caso de hemicorea asociada a toxoplasmosis cerebral y SIDA en nuestro pais. Hombre de 26 anos, con diagnostico de SIDA y toxoplasmosis cerebral. Habia comenzado con crisis motoras simples de hemicuerpo izquierdo, con generalization secundaria y luego perdida de fuerza progresiva en dicho hemicuerpo. La RMN de cérebro mostro una lesion frontal derecha y otra temporo-occipital izquierda, con gran edema perilesional y efecto de masa. Las serologias para HIV y toxoplasmosis fueron positivas. Comenzo tratamiento con sulfadiazina y pirimetamina. Al duodecimo dia aparecieron movimientos involuntários dei pie izquierdo, coreicos, que se extendieron mas tarde a todo ese miembro inferior y luego al hemicuerpo. Nueva RMN de cérebro mostro disminucion dei edema y efecto de masa de las lesiones. Sin embargo, se observo una nueva lesion a nivel peduncular derecho. Movimientos involuntarios en pacientes con toxoplasmosis cerebral comenzaron a describirse recientemente solo en pacientes con SIDA. El presente seria el decimotercer caso de la literatura mundial y el primero en nuestro pais de hemicorea asociada a toxoplasmosis y SIDA.

  3. Estudio de relación entre Niveles de Violencia en Población masculina Privada de Libertad (PPL en El Salvador y conocimientos de VIH, Vulnerabilidad asociada con VIH/Sida

    Directory of Open Access Journals (Sweden)

    Marcos Joshua Mariño Lozano

    2012-01-01

    Full Text Available El presente estudio muestra, los resultados de evaluar los niveles de violencia presentes en Personas Privadas de Libertad (PPL asociadas a la situación del VIH/Sida y su Vulnerabilidad ante la misma. Entendiendo como Vulnerabilidad el término que hace referencia a, las condiciones que una persona puede presentar en su vida que no permiten a la misma llevar actitudes correctas basadas en un cumulo de conocimientos considerado adecuado también. De aquí surge la necesidad de realizar este estudio, con el fin de determinar las herramientas necesarias para alcanzar las metas individuales en este tipo de población, así como las mismas les permitan disminuir su condición de vulnerabilidad ante la epidemia del VIH. La investigación se llevó a cabo con PPL del Centro Penal de Ciudad Barrios en San Miguel, El Salvador. Se realizó una encuesta a 175 internos donde se tomaron en cuenta variables como: edad, ocasiones que ha sido procesado en un centro penal (reincidencia, niveles de violencia, conocimientos y actitudes correctas ante el VIH/Sida Los resultados apuntan a que la mayor parte de la población es joven y se encuentran en su primer proceso como mayores de edad. Por su parte la mayoría presenta afinidad de incorporarse a un sector laboral como una manera de generar sus propios ingresos. La mayor parte de la población encuestada, muestra que a lo largo de su vida han desarrollado elevados niveles de violencia, y una gran necesidad de conocimientos correctos sobre VIH, lo que se demuestra con los altos índices de ausencia de buenas prácticas ante la epidemia-no hay un buen uso del condónfenómeno que refleja no estar sensibilizados sobre la situación.

  4. Estudio de relación entre Niveles de Violencia en Población masculina Privada de Libertad (PPL en El Salvador y conocimientos de VIH, Vulnerabilidad asociada con VIH/Sida

    Directory of Open Access Journals (Sweden)

    Marcos Joshua Mariño Lozano

    2012-01-01

    Full Text Available El presente estudio muestra, los resultados de evaluar los niveles de violencia presentes en Personas Privadas de Libertad (PPL asociadas a la situación del VIH/Sida y su Vulnerabilidad ante la misma. Entendiendo como Vulnerabilidad el término que hace referencia a, las condiciones que una persona puede presentar en su vida que no permiten a la misma llevar actitudes correctas basadas en un cumulo de conocimientos considerado adecuado también. De aquí surge la necesidad de realizar este estudio, con el fin de determinar las herramientas necesarias para alcanzar las metas individuales en este tipo de población, así como las mismas les permitan disminuir su condición de vulnerabilidad ante la epidemia del VIH. La investigación se llevó a cabo con PPL del Centro Penal de Ciudad Barrios en San Miguel, El Salvador. Se realizó una encuesta a 175 internos donde se tomaron en cuenta variables como: edad, ocasiones que ha sido procesado en un centro penal (reincidencia, niveles de violencia, conocimientos y actitudes correctas ante el VIH/Sida Los resultados apuntan a que la mayor parte de la población es joven y se encuentran en su primer proceso como mayores de edad. Por su parte la mayoría presenta afinidad de incorporarse a un sector laboral como una manera de generar sus propios ingresos. La mayor parte de la población encuestada, muestra que a lo largo de su vida han desarrollado elevados niveles de violencia, y una gran necesidad de conocimientos correctos sobre VIH, lo que se demuestra con los altos índices de ausencia de buenas prácticas ante la epidemia-no hay un buen uso del condón- fenómeno que refleja no estar sensibilizados sobre la situación.

  5. Frecuencia de mutaciones asociadas con resistencia a pirimetamina y sulfadoxina. Análisis de muestras clínicas procedentes de un área endémica para Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Moisés Wasserman

    2000-02-01

    Full Text Available

    Debido a la aparición y dispersión de parásitos de Plasmodium resistentes a los medicamentos de mayor uso, la malaria es hoy por hoy uno de los más serios problemas de salud pública. Considerando la dificultad intrínseca de adelantar estudios «in vivo», las pruebas «in vitro» han sido una estrategia alterna para establecer la situación y la magnitud de la resistencia en un área específica. En P. falciparum la resistencia “in vitro” a pirimetamina y sulfadoxina parece estar determinada por mutaciones en los genes que codifican para sus respectivas enzimas blanco: dihidrofolato reductasa (DHFR y dihidropteroato sintetasa (DHPS. En DHFR las mutaciones Asn108 y Thr108 están asociadas con pérdida de sensibilidad «in vitro» a pirimetamina y cicloguanil respectivamente, la mutación Arg59 modula el nivel de resistencia «in vitro» a pirimetamina y la mutación Leu164 confiere resistencia a los dos medicamentos cuando se suma a Asn108 y Arg59. Sobre DHPS también se han encontrado mutaciones posiblemente involucradas en resistencia a sulfadoxina: Phe436, Ala436, Thr613 y Ser613 entre otras.

    Se analizaron 55 muestras sanguíneas (extendidos de pacientes infectados con P. falciparum provenientes de Panguí-Choco*, haciendo extracción de ADN y amplificando los genes DHFR y DHPS mediante reacción en cadena de la Polimerasa (PCR; posteriormente y por medio de PCR anidado, se determinó la presencia de las mutaciones Asn108 y Thr108 para todos los aislamientos y de las mutaciones Arg59, Leu164, Phe436, Ala436, Thr613 y Ser613 para algunos de ellos.

    Aunque el 43% de la población presentó la mutación asociada con resistencia «in vitro

  6. Evaluación de pasturas de Brachiaria decumbens solas o asociadas con Centrosema acutifolium con ganado de doble propósito: I. Evaluación de la disponibilidad, composición botánica, frecuencia y calidad forrajera

    Directory of Open Access Journals (Sweden)

    Ramírez Náder Luis Miguel

    1991-12-01

    . decumbens in associate pasture was more higher 6.4% than alone pasture 5.2 %. The IN VITRO digestibility for the dry matter (IVDM was lower for th C. acutifolium , related to the B. decumbens in associate pasture and m alone pasture, with means of 37.9, 55,2 and 55,2% respectively.

    La investigación se realizó en Florida, Valle del Cauca, al suroccidente de Colombia (3° 20' N; 76° 14' 0; 1150 m de altitud, temperatura media 25°C; precipitación media anual de 1.339 m en un área de suelos INCEPTISOLES ligeramente ácidos (pH 5.8-6.3. Se utilizaron 4 praderas de 4 ha, cada una, dos de ellas establecidas con B. decumbens solo y las otras dos con B. decumbens asociado, las cuales se pastorearon en forma alterna cada 21 días asignándose una carga de 1.5 animales/ha. Las evaluaciones se realizaron utilizando el método de muestreo de BOTANAL-2. Hubo mayor disponibilidad de Materia Seca Verde de gramínea (MSVG y de leguminosa (MSVL, así como de Materia Seca Total (MST en la pastura asociada que en la pastura sola, a través de todos los períodos de medición, con medias de 4.627 vs. 2.296; 689 vs 45; kg/ha y 6.476 vs. 3.698 kg/ha respectivamente. En contraste hubo menor disponibilidad de Materia Seca Verde de malezas (MSVM y la del material inerte (MSMI en la pastura asociada en relación a la pastura sola, con medias de 265 vs 345 y 631 vs 798 kg/ha, respectivamente. La composición botánica presentó proporciones más estables y mayores de gramínea 72% y de leguminosa 11%en la pastura asociada, que en la pastura sola con 65 y 1%, respectivamente. La frecuencia de presencia de B. decumbens fue similar en las pasturas asociada, 96% y sola 98%. La frecuencia de C. acutifolium fue mayor en la pastura asociada 81%, que en la pastura sola 12%. Así mismo, en la pastura asociada se obtuvieron los menores valores en la frecuencia de malezas 47% y material inerte 84% que en la pastura sola con 52 y 97% respectivamente. El porcentaje de suelo descubierto fue menor en la

  7. EVALUACIÓN DE LA ACTIVIDAD FOTOSINTÉTICA ASOCIADA CON EL INTERCAMBIO GASEOSO DE DOS VARIEDADES DE Coffea arabica OBTENIDAS POR CULTIVO In Vitro

    Directory of Open Access Journals (Sweden)

    Elizabeth Isaac

    2010-01-01

    Full Text Available El trabajo se desarrolló en el Laboratorio de Células y Cultivo de Tejidos del Centro de Bioplantas en julio de 2007, con el objetivo de evaluar la actividad fotosintética de las plántulas de Coffea arabica var. Catuai y Caturra rojo, obtenidas in vitro en fase de multiplicación. Se determinaron la tasa de fotosíntesis neta, transpiración, conductancia estomática y concentración de pigmentos clorofílicos para cada una de las variedades a las ocho semanas de cultivadas; las vitroplantas crecieron en condiciones controladas en un medio MS suplementado con 0,5 ¿mol de AIA y 5 ¿mol de 6-BAP. Los resultados mostraron que ambas variedades desarrolladas in vitro presentaron tasas de fotosíntesis neta similares a las plantas de cafeto adultas cultivadas en condiciones de campo, lo que demostró la capacidad de fotosíntesis de las plántulas, conservando un adecuado equilibrio para el intercambio gaseoso en el proceso fotosintético durante la etapa de multiplicación in vitro.

  8. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Bravo

    2008-03-01

    Full Text Available Introducción: El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos: Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI, displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos: En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento.Resultados: La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9% y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0

  9. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1

    Science.gov (United States)

    Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

    2014-01-01

    RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las

  10. Análisis relacional de las contingencias asociadas a las prácticas deportivas con los trastornos de alimentación en adolescentes entre los 16 a 18 años

    Directory of Open Access Journals (Sweden)

    Marcela Noreña Mejía

    2006-01-01

    Full Text Available Este estudio analizó las contingencias asociadas a las prácticas deportivas y su relación con trastornos de alimentación en 42 mujeres adolescentes entre los 16 y 18 años de Bogotá, asignadas intencionalmente en tres grupos: Grupo A, adolescentes que pertenecen a un equipo deportivo; Grupo B, adolescentes que practican deporte con regularidad y Grupo C, adolescentes que no practican deporte, salvo la clase de educación física. El marco explicativo que sustenta la investigación se deriva del análisis experimental del comportamiento bajo el modelo de anorexia por actividad (Pierce y Epling, 1993. Se utilizó un protocolo de evaluación compuesto por la prueba Eating Disorder Inventory (Garner et al, 1983, que busca medir trastornos de alimentación, previamente validada para esta población, y una entrevista conductual para conocer factores sociodemográficos, psicosociales y tipos de prácticas deportivas igualmente validada. Esta es una investigación no experimental de naturaleza descriptiva y correlacional con un diseño de comparación de grupos. Los análisis demostraron relaciones significativas entre los tres grupos, de lo cual se concluye que hay riesgo de desarrollar trastornos de alimentación en la población en general, siendo más vulnerable el grupo B, lo cual coincide con los reportes la literatura. Las jóvenes del grupo A realizan deporte con un equipo donde se buscan resultados y triunfos, más que una imagen corporal determinada, mientras que el grupo C, no realiza ningún tipo de deporte o ejercicio físico, aunque presentan niveles considerables de preocupación por la imagen corporal. Se recomendó a los profesionales de la salud, profesores y entrenadores conocer los trastornos de alimentación y los riesgos que puede presentar el realizar ejercicio, practicar deporte o el sedentarismo si son realizados de forma inadecuada.

  11. Rupture of hepatic artery aneurysm associated with ischemic hepatitis Rotura de arteria hepática aneurismática asociada con hepatitis isquémica

    Directory of Open Access Journals (Sweden)

    V.M. Santos

    2010-08-01

    Full Text Available Hepatic artery aneurysms are scarcely reported, mainly because of non-specific symptoms. More often, they are incidental findings during imaging studies to investigate other acute or chronic abdominal conditions. These aneurysms are usually detected in the sixth decade of life, predominantly among males. We report the case of a 69 year-old female with an unsuspected huge hepatic artery aneurysm associated with ischemic hepatitis. Suspicion of aneurysm arose during imaging studies to clarify the origin of jaundice and abdominal pain. After establishment of the diagnosis, but before open surgery, there was a spontaneous rupture of the aneurysm, which caused hemoperitoneum and death. The necropsy study confirmed ischemic hepatitis. Hepatic artery aneurysms are second among the visceral aneurysms, and may cause abdominal pain, jaundice, and hemorrhagic events. One should suspect abdominal aneurysms in elderly patients with unclear abdominal pain, and this hypothesis should be ruled out by imaging studies.La publicación de trabajos sobre aneurismas en la arteria hepática es escasa, debido a los síntomas no específicos y a que constituyen hallazgos incidentales durante investigación de otras condiciones abdominales agudas o crónicas. Estos aneurismas son más frecuentes en varones y en la sexta década de la vida. Presentamos el caso de una mujer de 69 años de edad que ingresa en el hospital con un aneurisma de arteria hepática no sospechado previamente, asociado con hepatitis isquémica. La sospecha de aneurisma empezó durante estudio de imágenes para aclaramiento del origen de ictericia y dolor abdominal. Después de confirmado el diagnóstico, pero antes de la operación planeada, ocurrió rotura espontánea del aneurisma causando hemoperitoneo y muerte. El estudio de necropsia confirmó hepatitis isquémica. Los aneurismas de la arteria hepática son los segundos entre los aneurismas viscerales y pueden causar dolor abdominal, ictericia

  12. Respuesta tensiomiográfica aguda asociada al entrenamiento muscular con sobregarga excéntrica en jóvenes futbolistas de élite

    OpenAIRE

    Vallejo Espinosa, Antonio

    2013-01-01

    El objetivo principal de este estudio es el de medir la respuesta tensiomiográfica aguda en jóvenes futbolistas de élite tras un entrenamiento de fuerza enfocado a la musculatura de la rodilla, con sobrecarga excéntrica. Para ello, un total de dieciocho jugadores de fútbol (edad = 17 ± 1.2 años; altura = 178 ± 2,34 cm; peso = 71 ± 4.56 kg; IMC = 19.12 ± 2.45) pertenecientes a la cantera de un equipo profesional de fútbol de la liga española realizaron tres sesiones de entrenamiento: una situa...

  13. EVALUACIÓN DE TRES LEGUMINOSAS COMO COBERTURAS ASOCIADAS CON MAÍZ EN EL TRÓPICO SUBHÚMEDO

    Directory of Open Access Journals (Sweden)

    Jos\\u00E9 Bernardino Castillo-Caamal

    2010-01-01

    Full Text Available El objetivo fue evaluar el potencia l de tres leguminosas como coberturas para mejorar el sistema de producción de maíz. Se evaluaron cuatro tratamie ntos: 1 maíz solo; 2 maíz y Phaseolus lunatus de ciclo corto de semilla blanca 3 maíz y Phaseolus lunatus de ciclo largo de semilla blanca y 4 maíz y frijol terciopelo (Mucuna sp. en un diseño experimental de bloques al azar, con cuatro réplicas, durante cuatro ciclos de cultivo (1999-2002 en Yucatán, México. Se midió la biomasa de cultivos, pH, N total, mineralización potencia l anaerobia del nitrógeno, evolución del CO 2, potasio (K, fósforo (P y materia orgánica del suelo, biomasa y frecuencia de arvenses. La cantidad de rastrojo en los tratamie ntos con leguminosas fue: 3436, 3425 y 4018 kg MS /ha para el primero, segundo y tercer año, respectivamente. El nitrógeno aportado por los rastrojos al maíz fue 25,8; 31,9; 52,8 y 43,4 kg/ha para los tratamie ntos 1, 2, 3 y 4, respectivamente. El rendimie nto de grano de maíz fue en promedio 841, 843 y 460 kg MS /ha para el primero, segundo y tercer ciclo, respectivamente; sin diferencias entre tratamie ntos. En el tercer ciclo, el frijol terciopelo disminuyó la biomasa de arvenses de 126 a 58 g MS /m2. Las coberturas ejercieron poca influencia en las variables de suelo y rendimie nto de grano de maíz.

  14. Uso de una emulsión lipídica de nutrición parenteral a base de ácidos grasos omega 3 en pacientes menores de 18 años hospitalizados con alteración de las pruebas hepáticas asociada a la nutrición parenteral total

    OpenAIRE

    Adriana Giraldo Villa; Catherine Henao Roldan; Fanny García Loboguerrero; María Isabel Martínez Volkmar; Mónica María Contreras Ramírez; Patricia Ruiz Navas

    2014-01-01

    Introducción: La Nutrición Parental Total (NPT) prolongada está asociada con complicaciones potencialmente mortales en la población pediátrica como lo es la colestasis. Dentro del soporte nutricional, la fuente de ácidos grasos, el contenido de fitoesteroles y la dosis de lípidos se han relacionado con el desarrollo de esta complicación. Objetivo: Describir el comportamiento de las pruebas hepáticas en pacientes pediátricos con NPT en quienes se usó lípidos a base de ácidos grasos omega 3 (om...

  15. TALASEMIA ASOCIADA A EMBARAZO

    OpenAIRE

    Evans M,Gregorio; Poulsen R.,Ronald; Canahuate,Juan Carlos; Pastor,José Luis

    2003-01-01

    La Talasemia es un desorden congénito hemolítico causado por una deficiencia parcial o completa de la síntesis de las cadenas alfa o beta de las globinas de la hemoglobina. Se manifiesta en una amplia gama de cuadros clínicos que van desde la muerte intrauterina hasta la microcitosis asintomática sin anemia. El depósito de hierro constituye la complicación más importante de la talasemia y su mayor preocupación en el manejo. Existen escasos reportes de esta condición asociada a embarazo, se sa...

  16. Efecto de la Levadura de cerveza (S. cerevisiae asociada con vitamina E sobre las variables productivas y la calidad de la canal de pollos parrilleros Yeast (S. cerevisiae - E vitamin combination over productive variables and quality carcass in broilers

    Directory of Open Access Journals (Sweden)

    M.J Linares

    2009-06-01

    Full Text Available El objetivo fue verificar la acción de Levadura de Cerveza asociada o no a vitamina E sobre las variables productivas y la calidad de la canal. Ciento veinte pollos parrilleros recibieron dietas Control, Vitamina 1 (V1, 50 ppm. de vitamina E, Vitamina 2 (V2, 100 ppm. de vitamina E, Vitamina 3 (V3, 200 ppm. de vitamina E, y Levadura mas Vitamina (L+V, 0,3 % de Levadura + 200 ppm. de vitamina E; con cuatro repeticiones de seis aves cada una. De los 29 a los 52 días de vida se midieron Ganancia Media Diaria (GMD, Consumo Medio Diario (CMD e Índice de Conversión (IC, se determinaron % de Rendimiento de la canal (RC, Peso de Pechuga (% (PP, Peso de Muslos (% (PM y Peso de Grasa (% (PG. Se realizó un ANOVA con posterior test de Tukey, p≤ 0,05 fueron considerados significativos. Las aves que recibieron la asociación tuvieron significativamente mejor IC, mayor PM y menor PG, respecto a las otras. Se concluye que la combinación de la Levadura y la Vitamina E mejoró la performance productiva y la calidad de la canal al mejorar el IC, reducir el PG y aumentar el PM en las aves que la recibieron.The aim was to estimate the action of yeast (S. Cerevisiae-vitamin E combinated or not over the productive variables and quality carcass. One hundred and twenty male broilers Cobb received the following diets: Control, Vitamin 1 (V1, 50 ppm E vitamin, Vitamin 2 (V2, 100 ppm E vitamin, Vitamin 3 (V3, 200 ppm E vitamin and Yeast plus Vitamin (Y+V, 0,3 % yeast + 200 pp E vitamin with six chicken per pen and four pen for ration Since 29 till 52 days old the Average Daily Consumption (ADC, Average Daily Gain (ADG and Conversion Index (CI were measured. % carcass yield (CY, % breast weigh (BW, % leg muscles weigh (LMW and % fat weigh (FW were determinated. An ANOVA and a tukey test were made, significant differences were considered if p≤ 0,05. The broiler that received the combination of yeast and E vitamin had significantly best CI and hight LMW and lower FW

  17. Factores de riesgo de aparición de bacteriemia asociada al catéter en pacientes no críticos con nutrición parenteral total

    Directory of Open Access Journals (Sweden)

    María Julia Ocón Bretón

    2013-06-01

    Full Text Available Introducción: La bacteriemia asociada al catéter (BAC es una de las complicaciones más importantes en pacientes portadores de un catéter venoso central (CVC debido a su asociación con un incremento en la mortalidad, morbilidad y gasto sanitario. La administración de nutrición parenteral total (NPT aumenta el riesgo de aparición de BAC. El objetivo de nuestro estudio fue determinar la tasa de incidencia y los factores de riesgo de BAC en pacientes con NPT hospitalizados en plantas médico-quirúrgicas. Métodos: Estudio observacional, analítico, retrospectivo donde se analizaron a todos los pacientes adultos no críticos que precisaron NPT desde enero de 2010 hasta noviembre de 2011. El punto final clínico fue la BAC. La tasa de incidencia de BAC se calculó en forma de episodios por cada 1.000 pacientes-día de cateterización. Los factores predictivos independientes de BAC se determinaron mediante regresión logística. Resultados: Durante el periodo de estudio precisaron NPT un total de 331 pacientes. La duración media del CVC fue de 12,4 (DE 8,7 días y la NPT fue infundida durante un periodo medio de 10,4 (DE 8,3 días. 47 pacientes presentaron BAC, con una tasa de incidencia de 11,4/1.000 pacientes-día de CVC y de 13,7/1.000 pacientes-día de NPT. Los factores predictores univariantes de aparición de BAC fueron la permanencia del CVC superior a 20 días (OR = 2,48; IC 95%: 1,16-5,26, la duración de la NPT superior a 2 semanas (OR = 4,63; IC 95%: 2,16-9,90 y la presencia de fístulas (OR = 3,08; IC 95%: 1,24-7,63. En análisis multivariante, el único predictor independiente de BAC fue la duración de la NPT (OR para una duración superior a 14 días = 4,9; IC 95%: 2,2-10,9; p < 0,0001. Conclusiones: En pacientes adultos hospitalizados en plantas diferentes a UCI, hemos demostrado que la duración de la infusión de la NPT incrementa el riesgo de BAC. El incremento de riesgo es especialmente marcado, llegando a multiplicarse

  18. Enfermedad pulmonar intersticial asociada a rituximab

    Directory of Open Access Journals (Sweden)

    Marcelo Fernández Casares

    2013-08-01

    Full Text Available La introducción en la práctica clínica del anticuerpo anti-CD20 rituximab ha mejorado sustancialmente el pronóstico de diversas enfermedades autoinmunes y hematológicas. Con el incremento de su uso ha aumentado el registro de efectos adversos, entre ellos la toxicidad pulmonar. Una de sus complicaciones más serias es la enfermedad pulmonar intersticial, entidad potencialmente fatal que debe ser considerada en pacientes que han recibido rituximab y presentan disnea, fiebre y tos sin clara evidencia de infección. Presentamos un caso de enfermedad pulmonar intersticial asociada a rituximab.

  19. EL ENTRENAMIENTO DE FUERZA DEL TREN SUPERIOR CON CARGAS ASOCIADAS A LA MÁXIMA POTENCIA INDIVIDUAL: ANÁLISIS DE LOS EFECTOS AGUDOS SOBRE LA POTENCIA MECÁNICA

    Directory of Open Access Journals (Sweden)

    E. Iglesias

    2010-09-01

    Full Text Available

     

    RESUMEN

    El propósito del presente trabajo fue valorar el efecto agudo del entrenamiento de fuerza explosiva sobre el rendimiento mecánico. De una muestra de 9 sujetos masculinos se obtuvo la máxima carga movilizable en una sola repetición concéntrica (1RM del ejercicio press banca y la resistencia correspondiente al máximo nivel de potencia. Posteriormente se desarrollaron dos sesiones consistentes en 7 series de 3 repeticiones con las cargas asociadas a la máxima potencia individual. Previo a la primera serie de entrenamiento e inmediatamente posterior a la última se obtuvieron los niveles de potencia desarrollados tanto con el 90% 1RM como con la magnitud manejada en la sesión. Finalmente se llevó a cabo una evaluación postest. El ANOVA para medidas repetidas reflejó diferencias significativas al 90% 1RM (p<0.05 aunque los contrastes de los valores previos y posteriores a cada una de las sesiones no alcanzó significación estadística (p>0.005 en ninguna de las variables. No se detectó asociación estadísticamente significativa entre las modificaciones agudas del rendimiento y el nivel de fuerza de los sujetos. Sin embargo, si se halló correlación significativa (p<0.05 entre éste parámetro en el postest y el porcentaje de 1RM que suponía la carga de máxima potencia en la última medición.
    PALABRAS CLAVE: fuerza, cargas de contraste, press banca, potencia.

     

    ABSTRACT

    The purpose of this study was to measure the acute effect of two explosive strength sessions on mechanical performance. In order to do that, 1 repetition maximum and maximum power load were obtained in 9 men. The experimental procedure begun five days after and it involved two training sessions. 7 bouts of

  20. [Psychosocial aspects of preeclampsia].

    Science.gov (United States)

    Szita, Bernadett; Baji, Ildikó; Rigó, János

    2015-12-13

    Distress conditions during pregnancy may contribute to the development of preeclampsia by altering functions of the neuroendocrine and immune systems, e.g. activation of the hypothalamic-pituitary-adrenal axis and increase in plasma proinflammatory cytokines. Preeclampsia may also precipitate mental health problems due to long-term hospitalization or unpredictable and uncontrollable events such as preterm labor and newborn complications. Besides, preeclampsia may induce persistent neurocognitive complaints with a negative impact on patients' quality of life. As growing evidence indicates that poor maternal mental health has an adverse effect on pregnancy outcome and fetal development, psychosocial interventions may be beneficial for women with preeclampsia.

  1. La sustitución eucalórica de triglicéridos de cadena larga por triglicéridos de cadena media mejora la composición corporal y el perfil lipídico en un paciente con lipodistrofia asociada al virus de la inmunodeficiencia humana Eucaloric substitution of medium chain triglycerides for dietary long chain fatty acids improves body composition and lipid profile in a patient with human immunodeficiency virus lipodystrophy

    OpenAIRE

    C. Vázquez; Reyes, R; Alcaraz, F.; J. A. Balsa; J. I. Botella-Carretero

    2006-01-01

    Antecedentes: La lipodistrofia asociada a la infección por el virus de la inmunodeficiencia humana (VIH) es una patología frecuente, caracterizada por una pérdida de tejido adiposo en las extremidades, región glútea y cara, junto con un depósito excesivo del mismo en el cuello y abdomen. La coexistencia de dislipemia y diabetes mellitus en la lipodistrofia asociada al VIH es también frecuente, y aumenta el riesgo cardiovascular de los pacientes que la padecen. Aunque hay tratamientos disponib...

  2. Comparación de resultados obtenidos en el tratamiento del dolor miofascial de la cintura pélvica con toxina botulínica sola y asociada con lidocaína

    Directory of Open Access Journals (Sweden)

    I. Velázquez Rivera

    2014-10-01

    Full Text Available Objetivos: entre el 70 y el 85 % de la población adulta sufre de dolor de espalda alguna vez en su vida. El síndrome de dolor miofascial (SDM ha sido descrito recientemente definiéndose como dolor musculoesquelético no inflamatorio, localizado, desarrollado sin causa aparente, refractario a tratamientos farmacológicos y físicos, y se acompaña de la presencia de puntos gatillos y de bandas tensas palpables en el músculo. Su prevalencia se estima que varía entre un 30 y un 85 %. Los músculos psoas, cuadrado lumbar y piramidal son los más frecuentemente implicados en el SDM de cintura pélvica. Una de las principales alternativas para tratar el SDM es la toxina botulínica tipo A (TB, que actúa en la membrana sináptica en la placa neuromuscular, inhibiendo la liberación de acetilcolina, produciendo relajación muscular y alivio del dolor, aunque, en muchas ocasiones, su efecto no se hace evidente hasta transcurridos varios días. La lidocaína es un anestésico local (AL tipo amida con duración de acción intermedia que actúa impidiendo la propagación del impulso nervioso disminuyendo la permeabilidad de los canales de sodio. El objetivo de este estudio era comprobar si al añadir AL a ladosis de TB, conseguíamos un acortamiento en el tiempo dela reducción de la EVA y mejoría de la calidad de vida. Material y métodos: el diseño del estudio fue prospectivo, controlado, longitudinal y aleatorizado en el que se ha valorado la evolución de 20 pacientes divididos en dos grupos. Al primer grupo se les administró TB tipo A (grupo T. Al segundo grupo se les trató con TB tipo A y dosis adicional de lidocaína al 2% (grupo TL. Previamente, ambos grupos, habían respondido de forma positiva a un test con infiltración del músculo afecto con lidocaína al 2 %. El seguimiento de los pacientes se hizo secuencialmente a los 3, 7, 15 y 90 días de iniciado el tratamiento. Para el análisis estadístico se utilizó un análisis de la

  3. Diagnóstico precoz de la neumonía asociada al ventilador. Evaluación seriada de biomarcadores en minilavado broncoalveolar y monitorización microbiológica, complementado con condensado de aire exhalado y sangre.

    OpenAIRE

    Borrás Pallé, Santiago

    2015-01-01

    La Neumonía asociada a ventilación mecánica (NAV) es un tipo de neumonía nosocomial que se desarrolla tras más de 48 horas de VM, siendo una complicación frecuente y grave cuyo pronóstico se ensombrece por un diagnóstico y tratamiento tardío. Desgraciadamente, con las herramientas actuales no siempre es posible llegar a un diagnóstico correcto y definitivo. El desarrollo de la misma es un proceso dinámico y dado que debe existir una respuesta inflamatoria precoz ante la infección, inicia...

  4. Preeclampsia: Syndrome or Disease?

    Science.gov (United States)

    Myatt, Leslie; Roberts, James M

    2015-11-01

    The focus on disease mechanisms underlying the hypertension and proteinuria defining preeclampsia has increased knowledge of the pathophysiology yet we lack both therapy and predictors. We propose this is in part due to the fact that diagnostic findings identify a "preeclampsia syndrome" but do not necessarily indicate the most important pathophysiology nor if organs are involved as cause or consequence. The increased risk for later life cardiovascular disease in women who develop preeclampsia suggests the stress test of pregnancy exposes pre-existing subclinical vascular disease. The dogma that inadequate trophoblast invasion and ischemia/reperfusion injury to the placenta is "the" cause of preeclampsia is more relevant to early onset preeclampsia (preeclampsia where maternal constitutive factors or susceptibility to vascular damage is more relevant. The contribution of differing disease phenotypes to the syndrome may explain the inability of biomarker studies to identify all preeclampsia. Identification of phenotypes will require large amounts of prospective clinical data and biospecimens, collected in a harmonized manner with analysis in an unbiased discovery approach.

  5. ANDROGEN LEVELS IN PREECLAMPSIA

    Directory of Open Access Journals (Sweden)

    M. Valadan

    2006-08-01

    Full Text Available Preeclampsia is a major cause of morbidity and mortality during pregnancy. Several independent investigators have demonstrated the association of androgens with hypertension. The main purpose of this study was to determine whether maternal levels of sex hormones, especially testosterone, are higher in patients with preeclampsia than in matched normotensive control subjects. Serum levels of testosterone, free testosterone, dehydroepiandrosterone sulfate (DHEA-S and estradiol were measured in 60 subjects in the 3rd trimester of pregnancy with documented preeclampsia (including 30 cases of mild and 30 cases of severe preeclampsia and 60 healthy normotensive women with similar maternal and gestational ages and body mass index (BMI and neonatal sex. All subjects were primigravid with singleton pregnancies. Cases of polycystic ovary (PCO, diabetes, chronic hypertension and chronic systemic diseases such as lupus and patients using steroid hormones and anti-hypertensive drugs were excluded. Levels of testosterone, DHEA-S and estradiol were not higher in primigravid women with preeclampsia than in normotensive women with similar gestational and maternal ages, BMI and neonatal sex. There were no significant differences in sex hormones measured between groups of mild and severe preeclampsia and normotensive women. There were also no significant differences in sex hormone levels according to neonatal sex. These findings are against the hypothesis of mediating or amplifying role of high androgen levels in pathophysiology of preeclampsia.

  6. Cereral Circulation in Preeclampsia

    Directory of Open Access Journals (Sweden)

    A. A. Ivshin

    2008-01-01

    Full Text Available Objective: to evaluate the possibilities of using transcranial Doppler study in pregnant women and pueperas with preeclamp-sia. Subjects and methods. Two hundred and thirty-two pregnant women diagnosed as having varying preeclampsia were prospectively studied. A comparison group comprised 90 apparently healthy women in the third trimester of pregnancy. All the respondents underwent transcranial duplex scanning of the medial cerebral artery with the linear velocity values being determined. A number of the values reflecting the level of perfusion and intracranial pressures, hydrodynamic resistance in the system, cerebrovascular responsiveness and the state of the vascular wall were calculated. Correlation analysis was made between the parameters of cerebral circulation and the severity of preeclampsia, proteinuria, the severity of hydrops, and the parameters of central and peripheral hemodynamics. Results. The findings suggest that there is impaired cerebral perfusion in pregnant women and puerperas with varying preeclampsia, the severity of cerebral circulatory disorders being in proportion with that of preeclampsia. There is a close correlation between cerebral circulation and the individual criteria determining the severity of preeclampsia. The linear values of the Doppler spectrum, namely linear flow characteristics, are prognos-tically most significant. Conclusion. The introduction of transcranial Doppler study into obstetric care has permitted the authors not only to study cerebral circulatory disorders in healthy and pregnant women and puerperas with preeclampia in detail, but also to establish a number of highly significant prognostic criteria for the severity of this life-threatening complication of gestation. The results of transcranial Doppler study assist practitioners in timely and accurately solving the problems in the diagnosis of preeclampsia and in evaluating its severity. Cerebral circulatory values may be successfully used to

  7. Pre-eclampsia.

    Science.gov (United States)

    Mol, Ben W J; Roberts, Claire T; Thangaratinam, Shakila; Magee, Laura A; de Groot, Christianne J M; Hofmeyr, G Justus

    2016-03-05

    Pre-eclampsia affects 3-5% of pregnancies and is traditionally diagnosed by the combined presentation of high blood pressure and proteinuria. New definitions also include maternal organ dysfunction, such as renal insufficiency, liver involvement, neurological or haematological complications, uteroplacental dysfunction, or fetal growth restriction. When left untreated, pre-eclampsia can be lethal, and in low-resource settings, this disorder is one of the main causes of maternal and child mortality. In the absence of curative treatment, the management of pre-eclampsia involves stabilisation of the mother and fetus, followed by delivery at an optimal time. Although algorithms to predict pre-eclampsia are promising, they have yet to become validated. Simple preventive measures, such as low-dose aspirin, calcium, and diet and lifestyle interventions, show potential but small benefit. Because pre-eclampsia predisposes mothers to cardiovascular disease later in life, pregnancy is also a window for future health. A collaborative approach to discovery and assessment of the available treatments will hasten our understanding of pre-eclampsia and is an effort much needed by the women and babies affected by its complications.

  8. ADIPONECTIN IN SEVERE PREECLAMPSIA

    Science.gov (United States)

    Nien, Jyh Kae; Mazaki-Tovi, Shali; Romero, Roberto; Erez, Offer; Kusanovic, Juan Pedro; Gotsch, Francesca; Pineles, Beth L.; Gomez, Ricardo; Edwin, Samuel; Mazor, Moshe; Espinoza, Jimmy; Yoon, Bo Hyun; Hassan, Sonia S.

    2008-01-01

    Aims Adiponectin is an adipokine with insulin-sensitizing, anti-atherogenic, anti-inflammatory and angiogenic properties. The aims of this study were to determine whether maternal plasma adiponectin concentrations differ between patients with severe preeclampsia and those with normal pregnancies, and to explore the relationship between plasma adiponectin and the results of Doppler velocimetry of the uterine arteries. Methods This case-control study included two groups: (1) patients with severe preeclampsia (n=50) and (2) patients with normal pregnancies (n=150). Pulsed-wave and color Doppler ultrasound examination of the uterine arteries were performed. Plasma adiponectin concentrations were determined by ELISA. Non-parametric statistics were used for analysis. Results (1) Patients with severe preeclampsia had a higher median plasma concentration of adiponectin than that of normal pregnant women. (2) The median plasma adiponectin concentration did not differ between women with severe preeclampsia who had a high impedance to blood flow in the uterine arteries and those with normal impedance to blood flow. (3) Among patients with normal pregnancies, plasma adiponectin concentrations were negatively correlated with BMI in the first trimester and at sampling. Conclusions Women with severe preeclampsia have a higher median plasma concentration of adiponectin than that of normal pregnant women. This may reflect a compensatory feedback mechanism to the metabolically-altered, anti-angiogenic and pro-atherogenic state of severe preeclampsia. PMID:17919115

  9. On renal pathophysiology in preeclampsia

    OpenAIRE

    2014-01-01

    Preeclampsia is a complication of pregnancy which can suddenly change from a relatively mild phenotype into a life-threatening situation. One of the organs that is always involved during preeclampsia is the kidney. The placenta plays an important role in the renal pathophysiology of preeclampsia. The placenta produces excessive amounts of anti-angiogenic factors which are associated with systemic endothelial dysfunction. Although the underlying mechanisms of renal injury during preeclampsia r...

  10. On renal pathophysiology in preeclampsia

    NARCIS (Netherlands)

    Penning, Maria Elisabeth (Marlies)

    2014-01-01

    Preeclampsia is a complication of pregnancy which can suddenly change from a relatively mild phenotype into a life-threatening situation. One of the organs that is always involved during preeclampsia is the kidney. The placenta plays an important role in the renal pathophysiology of preeclampsia. Th

  11. Preeclampsia: an update.

    Science.gov (United States)

    Lambert, G; Brichant, J F; Hartstein, G; Bonhomme, V; Dewandre, P Y

    2014-01-01

    Preeclampsia was formerly defined as a multisystemic disorder characterized by new onset of hypertension (i.e. systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg) and proteinuria (> 300 mg/24 h) arising after 20 weeks of gestation in a previously normotensive woman. Recently, the American College of Obstetricians and Gynecologists has stated that proteinuria is no longer required for the diagnosis of preeclampsia. This complication of pregnancy remains a leading cause of maternal morbidity and mortality. Clinical signs appear in the second half of pregnancy, but initial pathogenic mechanisms arise much earlier. The cytotrophoblast fails to remodel spiral arteries, leading to hypoperfusion and ischemia of the placenta. The fetal consequence is growth restriction. On the maternal side, the ischemic placenta releases factors that provoke a generalized maternal endothelial dysfunction. The endothelial dysfunction is in turn responsible for the symptoms and complications of preeclampsia. These include hypertension, proteinuria, renal impairment, thrombocytopenia, epigastric pain, liver dysfunction, hemolysis-elevated liver enzymes-low platelet count (HELLP) syndrome, visual disturbances, headache, and seizures. Despite a better understanding of preeclampsia pathophysiology and maternal hemodynamic alterations during preeclampsia, the only curative treatment remains placenta and fetus delivery. At the time of diagnosis, the initial objective is the assessment of disease severity. Severe hypertension (SBP ≥ 160 mm Hg and/or DBP ≥ 110 mmHg), thrombocytopenia preeclampsia, and relies on antihypertensive medications and magnesium sulfate. Medical treatment does not alter the course of the disease, but aims at preventing the occurrence of intracranial hemorrhages and seizures. The decision of terminating pregnancy and perform delivery is based on gestational age, maternal and fetal conditions, and severity of preeclampsia

  12. Management of severe preeclampsia.

    Science.gov (United States)

    Brichant, G; Dewandre, P Y; Foidart, J M; Brichant, J F

    2010-01-01

    Features of severe preeclampsia include severe proteinuric hypertension and symptoms of central nervous system dysfunction, hepatocellular injury, thrombocytopenia, oliguria, pulmonary oedema, cerebrovascular accident and severe intrauterine growth restriction. Women with severe preeclampsia must be hospitalized to confirm the diagnosis, to assess the severity of the disease, to monitor the progression of the disease and to try to stabilize the disease. Severe preeclampsia may be managed expectantly, in selected cases. The objective of expectant management in these patients is to improve neonatal outcome. Expectant management is based on antihypertensive treatment and prevention of end organ dysfunction. Antihypertensive treatment improves maternal outcome but has the potential to be deleterious for the foetus. Plasma volume expansion has been suggested for severe preeclampsia but trials failed to show any benefit. Magnesium sulfate is the anticonvulsivant of choice to treat or prevent eclampsia when indicated. Antenatal corticosteroids are recommended in severely preeclamptic women with 26-34 weeks gestation. Timing of delivery is based upon gestational age, severity of preeclampsia, maternal and foetal risks.

  13. Biological rhythms and preeclampsia

    Directory of Open Access Journals (Sweden)

    Agnès eDitisheim

    2013-04-01

    Full Text Available The impact of impaired circadian rhythm on health has been widely studied in shift workers and trans-meridian travelers. A part from its correlation with sleep and mood disorders, biological rhythm impairment is a recognized risk factor for cardiovascular diseases and breast cancer.Preeclampsia is a major public health issue, associated with a significant maternal and fetal morbidity and mortality worldwide. While the risks factors for this condition such as obesity, diabetes, pre-existing hypertension have been identified, the underlying mechanism of this multi-factorial disease is yet not fully understood.The disruption of the light/dark cycle in pregnancy has been associated with adverse outcomes. Slightly increased risk for small for gestational age babies, low birth weight babies and preterm deliveries has been reported in shift working women. Whether altered circadian cycle represents a risk factor for preeclampsia or preeclampsia is itself linked with an abnormal circadian cycle is less clear. There are only few reports available, showing conflicting results. In this review, we will discuss recent observations concerning circadian pattern of blood pressure in normotensive and hypertensive pregnancies. We explore the hypothesis that circadian misalignments may represent a risk factor for preeclampsia. Unraveling potential link between circadian clock gene and preeclampsia could offer a novel approach to our understanding of this multi-system disease specific to pregnancy.

  14. Clinical, Epidemiological and Microbiological Study of Patients Admitted to Intensive Care Units with Mechanical Ventilation Related Pneumonia Estudio clínico, epidemiológico y microbiológico de pacientes con neumonía asociada a la ventilación mecánica ingresados en salas de cuidados intensivos

    Directory of Open Access Journals (Sweden)

    Ledys Pérez Morales

    2012-09-01

    Full Text Available Background: Mechanical ventilation related pneumonia is a very current issue due to its frequency, severity and etiologic and therapeutic implications. Objective: To characterize, from a clinical, epidemiological and microbiological point of view, patients with ventilation related pneumonia who are admitted to intensive care units. Methods: Descriptive case series study, conducted from January 2007 to December 2009, at the Laboratory of Microbiology and intensive care units of the Dr. Gustavo Aldereguía Lima General Hospital in Cienfuegos.  We analyzed the following variables: service that remitted patients, age, sex, cause of admission to intensive care unit, discharge status, microbiological results, isolated microorganisms, antimicrobial disks tested and antimicrobial resistance in vitro. Results: mechanical ventilation related pneumonia in intensive care units was observed mainly in male patients over 65 years old (43.1% with multiple trauma (20.9%; 20.9% were patients with cerebrovascular disease. Acinetobacter baumannii was the most frequently isolated organism in all units (41.4%, except in the Surgical Intensive Care Unit. It also reported a high mortality rate and in vitro resistance to all antimicrobials tested. Conclusions: Acinetobacter baumannii was the most isolated germen in cases of mechanical ventilation related pneumonia in intensive care units` patients. It affected mainly patients with multiple trauma and cerebrovascular disease.

    Fundamento: la neumonía asociada a la ventilación mecánica constituye un tema de actualidad por su frecuencia, gravedad e implicaciones etiológicas y terapéuticas. Objetivo: caracterizar clínica, epidemiológica y  microbiológicamente a pacientes con neumonía asociada al ventilador en las salas de cuidados intensivos. Métodos: estudio descriptivo de

  15. Preeclampsia and breast cancer

    DEFF Research Database (Denmark)

    Pacheco, Nadja Livia Pekkola; Andersen, Anne-Marie Nybo; Kamper-Jørgensen, Mads

    2015-01-01

    BACKGROUND: In parous women preeclampsia has been associated with reduced risk of developing breast cancer. Characteristics of births following preeclamptic pregnancies may help understand mechanisms involved in the breast cancer risk reduction inferred by preeclampsia. METHODS: We conducted...... a register-based cohort study of all Danish women giving birth during 1978-2010 (n = 778,701). The association between preeclampsia and breast cancer was evaluated overall and according to birth characteristics by means of incidence rate ratios (IRR) estimated in Poisson regression models. RESULTS: Compared...... with women with non-preeclamptic pregnancies only, women with one or more preeclamptic pregnancies were 19% significantly less likely to develop breast cancer (IRR = 0.81 [95% CI 0.72-0.93]). We found some indication of greater risk reduction in women with term births, one or more previous births...

  16. Retinal Detachment in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Prado Renata Silva do

    2002-01-01

    Full Text Available Preeclampsia is an obstetric disease of unknown cause that affects approximately 5% of pregnant women. The visual system may be affected with variable intensity, being the retinal detachment a rare complication. The retinal detachment in preeclampsia is usually bilateral and serous, and its pathogenesis is related to the choroidal ischemia secondary to an intense arteriolar vasospasm. The majority of patients have complete recovery of vision with clinical management, and surgery is unnecessary. This is a case report of a 27 year old patient who developed the severe form of preeclampsia on her first pregnancy. She had progressive blurred vision, until she could see only shadows. Ophthalmic examination diagnosed spread and bilateral retinal detachment. With blood pressure control at postpartum, the patient had her retina reattached, and recovery of vision.

  17. LIPID PEROXIDATION IN PREECLAMPSIA

    Directory of Open Access Journals (Sweden)

    T.Sharmila Krishna

    2015-03-01

    Full Text Available Hypertension in pregnancy is a leading cause of both maternal and fetal mortality and morbidity. Preeclampsia is characterised by hypertension and proteinuria. Lipid peroxidation is an important factor in the pathophysiology of Preeclampsia. The present study was undertaken to determine Serum Malondialdehyde (MDA levels , a product of lipid peroxidation , in clinically diagnosed Preeclamptic women(n=30 and the values were compared with that of Normotensive pregnant women (n=30 aged between 18-30yrs. All of them were in their third trimester and were primigravida. Serum MDA was estimated by TBARS (thiobarbituric acid reactive substances method. We observed that Serum MDA levels were significantly increased in Preeclamptic women (p <0.000 as compared to that of Normotensive pregnant women . Increased levels of lipid peroxiation product - MDA may contribute to the pathophysiology of Preeclampsia.

  18. Screening de primer trimestre de preeclampsia tardía en gestantes de bajo riesgo en un centro de bajo volumen obstétrico: validación externa de un modelo predictivo

    Directory of Open Access Journals (Sweden)

    D. Díaz Cobos

    2015-12-01

    Full Text Available Fundamento: La validación externa de un modelo predictivo de predicción de preeclampsia tardía en un centro de bajo volumen obstétrico en gestantes de bajo riesgo obstétrico. Métodos: Estudio prospectivo de 174 gestaciones únicas de 11+0 a 13+6 semanas de gestación en la Clínica Universidad de Navarra desde septiembre 2011 a marzo de 2013, que fue considerado como una cohorte de validación de un modelo descrito anteriormente para preeclampsia tardía en el hospital Clínic de Barcelona. Resultados: Un total de 7 (4% mujeres desarrollaron PE tardía. En la cohorte de validación el área bajo la curva del modelo fue de 0,69 (IC del 95% 0,45 a 0,93. Las tasas de detección para un 5, 10 y 15% de tasas de falsos positivos fueron 21,9, 31,4 y 38,6%. Al comparar las áreas bajo la curva de la cohorte de validación con la cohorte de la construcción, no se encontraron diferencias estadísticamente significativas (p = 0,68. Conclusión: La combinación de la historia clínica materna, la proteína placentaria A-asociada al embarazo y presión arterial media es moderadamente útil para predecir preeclampsia tardía en gestantes de bajo riesgo y en un centro de bajo volumen obstétrico. El modelo predictivo del hospital Clinic de Barcelona es una herramienta válida para predecir preeclampsia tardía en este entorno.

  19. Vascular dysfunction in preeclampsia.

    Science.gov (United States)

    Brennan, Lesley J; Morton, Jude S; Davidge, Sandra T

    2014-01-01

    Preeclampsia is a complex disorder which affects an estimated 5% of all pregnancies worldwide. It is diagnosed by hypertension in the presence of proteinuria after the 20th week of pregnancy and is a prominent cause of maternal morbidity and mortality. As delivery is currently the only known treatment, preeclampsia is also a leading cause of preterm delivery. Preeclampsia is associated with maternal vascular dysfunction, leading to serious cardiovascular risk both during and following pregnancy. Endothelial dysfunction, resulting in increased peripheral resistance, is an integral part of the maternal syndrome. While the cause of preeclampsia remains unknown, placental ischemia resulting from aberrant placentation is a fundamental characteristic of the disorder. Poor placentation is believed to stimulate the release of a number of factors including pro- and antiangiogenic factors and inflammatory activators into the maternal systemic circulation. These factors are critical mediators of vascular function and impact the endothelium in distinctive ways, including enhanced endothelial oxidative stress. The mechanisms of action and the consequences on the maternal vasculature will be discussed in this review.

  20. Calciuria and preeclampsia

    Directory of Open Access Journals (Sweden)

    Ramos J.G.L.

    1998-01-01

    Full Text Available Urinary calcium excretion has been reported to be diminished in preeclampsia. The objective of the present study was to determine urinary calcium excretion in pregnant patients with chronic arterial hypertension (CAH and preeclampsia (PE, and in normotensive patients (N. Forty-four pregnant patients (gestional age, 20-42 weeks; 18 CAH, 17 PE, 9 N were evaluated for calciuria, proteinuria, plasma uric acid and blood pressure. Patients with PE (82 ± 15.1 mg/24 h showed significantly lower calciuria (P<0.05 than the group with CAH (147 ± 24.9 mg/24 h and the N group (317 ± 86.0 mg/24 h (P<0.05, Student t-test. Plasma uric acid was significantly higher in the PE group (6.1 ± 0.38 mg/dl than the CAH group (5.0 ± 0.33 mg/dl; P<0.05, which also presented higher proteinuria levels, although the difference was not statistically significant. Diastolic and systolic blood pressure did not differ between the PE (164 ± 105 mmHg and CAH (164 ± 107 mmHg groups. Calciuria was significantly lower in the group with preeclampsia than in the group with chronic arterial hypertension. We conclude that calciuria can be a further factor for identifying preeclampsia

  1. Uso de una emulsión lipídica de nutrición parenteral a base de ácidos grasos omega 3 en pacientes menores de 18 años hospitalizados con alteración de las pruebas hepáticas asociada a la nutrición parenteral total

    Directory of Open Access Journals (Sweden)

    Adriana Giraldo Villa

    2014-04-01

    Full Text Available Introducción: La Nutrición Parental Total (NPT prolongada está asociada con complicaciones potencialmente mortales en la población pediátrica como lo es la colestasis. Dentro del soporte nutricional, la fuente de ácidos grasos, el contenido de fitoesteroles y la dosis de lípidos se han relacionado con el desarrollo de esta complicación. Objetivo: Describir el comportamiento de las pruebas hepáticas en pacientes pediátricos con NPT en quienes se usó lípidos a base de ácidos grasos omega 3 (omegaven®. Métodos: Estudio retrospectivo, en menores de 18 años con tratamiento intravenoso por mínimo 8 días con ácidos grasos omega 3. Los pacientes fueron inicialmente clasificados en dos grupos: colestasis y alteración de pruebas hepáticas. Se evaluó el comportamiento de la transaminasa glutámico oxalacética (TGO, transaminasa glutámico pirúvica (TGP, bilirrubina total (BT, bilirrubina directa, gama glutamil transferasa (GGT y fosfatasa alcalina (FA antes y después del tratamiento con omegaven®. Resultados: 33 pacientes cumplieron los criterios de inclusión. Al finalizar la administración de omegaven®, 82,4% de los pacientes que presentaron inicialmente colestasis mostraron resolución o mejoría. En el grupo de pacientes con alteración de pruebas hepáticas 18,8% progresaron a colestasis. Conclusiones: Nuestro estudio sugiere que el uso de omega-ven® en pacientes pediátricos con NPT y BD > 2 mg/dL, parece revertir o mejorar la colestasis, mientras que en pacientes con alteración de pruebas hepáticas aun no se tiene claro su efecto.

  2. Diferencias de la Función Ejecutiva en el Trastorno por Déficit de Atención con Hiperactividad y en sintomatologías asociadas

    OpenAIRE

    Araujo Jiménez, Eva Angelina

    2012-01-01

    El Trastorno por Déficit de Atención con Hiperactividad (TDAH) es uno de los trastornos más prevalentes en la infancia y se caracteriza por un marcado deterioro en la Función Ejecutiva. La cual es un factor fundamental para que el niño se desenvuelva y se adapte a las exigencias de su entorno inmediato. Los déficits en este funcionamiento afectan de manera directa el desempeño escolar, el aprendizaje y la socialización de los niños con TDAH, y son expresados en una mala regulación emocional y...

  3. Impacto de la maniobra de inspiración profunda en el intercambio gaseoso del sujeto con obesidad severa e hipertensión arterial pulmonar asociada a síndrome de Eisenmenger

    OpenAIRE

    Santos-Martínez,Luis-Efren; Martínez-Guerra,María-Luisa; Bautista, Edgar; Castillo, Francisco; Castañón,Alicia; Pulido,Tomás; Hernández,José-Luis; Sandoval,Julio

    2008-01-01

    La obesidad y el síndrome de Eisenmenger son entidades ampliamente estudiadas. Sin embargo, su asociación es inusual y no informada. Ambas cursan con alteraciones del intercambio gaseoso de grado variable. En la obesidad severa son atribuidas a trastornos en la relación ventilación/perfusión y al cortocircuito venoarterial pulmonar que dependen del volumen pulmonar. En el síndrome de Eisenmenger con obesidad severa, esta dependencia se desconoce. Material y métodos: Se estudiaron 28 sujetos o...

  4. La sustitución eucalórica de triglicéridos de cadena larga por triglicéridos de cadena media mejora la composición corporal y el perfil lipídico en un paciente con lipodistrofia asociada al virus de la inmunodeficiencia humana Eucaloric substitution of medium chain triglycerides for dietary long chain fatty acids improves body composition and lipid profile in a patient with human immunodeficiency virus lipodystrophy

    Directory of Open Access Journals (Sweden)

    C. Vázquez

    2006-08-01

    Full Text Available Antecedentes: La lipodistrofia asociada a la infección por el virus de la inmunodeficiencia humana (VIH es una patología frecuente, caracterizada por una pérdida de tejido adiposo en las extremidades, región glútea y cara, junto con un depósito excesivo del mismo en el cuello y abdomen. La coexistencia de dislipemia y diabetes mellitus en la lipodistrofia asociada al VIH es también frecuente, y aumenta el riesgo cardiovascular de los pacientes que la padecen. Aunque hay tratamientos disponibles para las alteraciones metabólicas asociadas, hasta la fecha no existen terapias con un claro beneficio demostrado para la lipodistrofia. Caso clínico: Un paciente de 42 años con lipodistrofia asociada al VIH fue inicialmente tratado con dieta hipocalórica (Background: Lipodystrophy is a frequent disorder among patients with human immunodeficiency virus (HIV infection, characterized by a loss of adipose tissue from the extremities, gluteal region and face, with excess fat in the neck and abdominal region. Metabolic abnormalities such as hyperlipidaemia and diabetes mellitus frequently coexist, posing these patients to an increased cardiovascular risk. Drug therapy may improve some of these metabolic disturbances, but to date there are no treatments for lipodystrophy with proven benefit. Case report: A 42 year old man with HIV lipodystrophy was started on a standard low caloric diet with <30% of total fat and < 10% of saturated fat, together with rosiglitazone 8 mg daily. After five months of treatment, given that lipodystrophic features and dyslipidaemia were still present in our patient, we tried to further improve therapeutic results by eucaloric substitution of medium chain triglycerides for dietary long chain fatty acids. Three months later, a dramatic change in body composition was shown with an increase in lean mass and a decrease in fat mass, together with an improvement in lipid profile. Conclusion: Eucaloric substitution of medium chain

  5. Mutation of neuronal channels of sodium and chloride associated with generalized epilepsy with febrile seizures plus (gefs+ Mutaciones de los canales neuronales de sodio y cloro asociadas a epilepsia generalizada con convulsiones febriles plus

    Directory of Open Access Journals (Sweden)

    Gabriel Bedoya Berrío

    2004-02-01

    Full Text Available Generalized Epilepsy with Febrile Seizures Plus (GEFS+ is a frequent entity characterized by generalized seizures with a wide phenotypic variety; the age of onset is 3 months and it persists beyond 6 years. Seizures may or may not be induced by fever. The disease has shown an autosomic dominant trait, incomplete penetrance and association with mutations on the genes that encode voltage-dependent sodium channels and the chloride neuronal channels on the central nervous system. The wide spectrum GEFS+ phenotype has been related with others entities such as Severe Myoclonic Epilepsy of Infancy (SMEI and Intractable Childhood Epilepsy with Frequent Generalized Tonic-Clonic Seizures (ICEGTC; they have mutations in common with GEFS+ according to several recently published articles. This review compiles up to date information about EGCF+ with the aim of giving the reader a knowledge of this entity and of its association with mutations that participate in its pathogenesis. La Epilepsia Generalizada Con Convulsiones Febriles Plus (EGCF+, es una entidad relativamente común. Se caracteriza por convulsiones de tipo generalizado con una gran variabilidad fenotípica; se presenta desde los 3 meses de edad y persiste más allá de los 6 años; las convulsiones pueden ser precipitadas por fiebre pero se presentan también sin ella. La enfermedad se ha asociado a herencia autosómica dominante con penetrancia incompleta, en la que intervienen mutaciones de los genes que codifican los canales iónicos de sodio dependientes del voltaje y de los canales iónicos de cloro en las neuronas del Sistema Nervioso Central (SNC. El amplio fenotipo de la EGCF+ se ha encontrado en asociación con otras entidades como la Epilepsia Mioclónica Severa del Lactante (EMSL y la Epilepsia Generalizada Tónico-Clónica Intratable de la Infancia (EGTCII, las cuales han presentado mutaciones comunes con las de la EGCF+, según informes recientemente publicados. Esta revisi

  6. Early Prediction of Preeclampsia

    Directory of Open Access Journals (Sweden)

    Leona C. Poon

    2014-01-01

    Full Text Available Effective screening for the development of early onset preeclampsia (PE can be provided in the first-trimester of pregnancy. Screening by a combination of maternal risk factors, uterine artery Doppler, mean arterial pressure, maternal serum pregnancy-associated plasma protein-A, and placental growth factor can identify about 95% of cases of early onset PE for a false-positive rate of 10%.

  7. Resiliencia y Variables Asociadas en Cuidadores Informales de Pacientes con Alzheimer/Resilience and Associated Variables in Informal Caregivers of Alzheimer Patients/Resiliência e Variáveis Associadas em Cuidadores Informais de Pacientes com Alzheimer

    Directory of Open Access Journals (Sweden)

    Ara Mercedes Cerquera Córdoba

    2016-03-01

    Full Text Available La resiliencia es una variable protectora ante el rol del cuidador, por ello, este estudio pretende identificar la relación entre la resiliencia y la sobrecarga, la depresión, la percepción de apoyo social y estrategias de afrontamiento. Se trata de un estudio transversal de alcance correlacional que contó con una muestra de 101 cuidadores, evaluados por medio de los instrumentos Zarit, mos, ider, Coping, la Escala de Resiliencia de Wagnild y Young. Se identificaron correlaciones positivas estadísticamente significativas entre apoyo social y solución de problemas como estrategia de afrontamiento y resiliencia, y correlaciones egativas con depresión, evidenciando en estos resultados los factores protectores y de riesgo que pueden aportar a la creación de futuros programas de intervención.

  8. Calcificación vascular asociada a inflamación : influencia de la vitamina D

    OpenAIRE

    Guerrero Pavón, Fátima

    2012-01-01

    Arteriosclerosis y aterosclerosis son procesos comunes en los pacientes con enfermedad renal crónica (ERC). De hecho, la calcificación vascular (CV) representa un importante factor de riesgo que contribuye a la alta tasa de mortalidad cardiovascular asociada a la ERC. En pacientes urémicos, la CV está causada, en parte, por alteraciones en el metabolismo mineral estrechamente relacionadas con el control del hiperparatiroidismo secundario (HPT2º). Los pacientes con ERC muestr...

  9. Assistência de Enfermagem na opinião das mulheres com pré-eclâmpsia Asistencia de Enfermería en la opinión de las mujeres con preeclampsia Nursing assistance in the opinion of women with pre-eclampsia

    Directory of Open Access Journals (Sweden)

    Karla Joelma Bezerra Cunha

    2007-06-01

    Full Text Available Estudo qualitativo cujo objeto é a assistência de enfermagem na ótica das mulheres com pré-eclâmpsia. Os objetivos foram descrever os motivos da hospitalização e suas expectativas; e discutir a assistência de enfermagem recebida em uma maternidade pública de Teresina - PI. A metodologia utilizada foi um formulário semi-estruturado cuja coleta dos dados foi realizada através da entrevista. Os resultados foram apresentados em categorias evidenciando como motivos mais comuns que levaram às 12 mulheres a internação: edema e cefaléia. A assistência de enfermagem prestada limitou-se à verificação da pressão arterial e administração de medicamentos. Quanto à satisfação referiram-se a realização dos procedimentos técnicos e a insatisfação destacou-se pela falta de atenção, apoio e diálogo. O relacionamento equipe de enfermagem-paciente foi considerado frio, impessoal e descompromissado. No entanto, há expectativas de maior humanização na equipe e o estabelecimento de ações confiáveis e motivacionais. Conclui-se que a assistência de enfermagem deva ser mais humana no atendimento às necessidades físicas, sociais e psicoemocionais dos clientesEstudio cualitativo cuyo objeto es la ayuda de enfermería en la óptica de las mujeres con preeclampsia. Los objetivos fueron describir las razones de la hospitalización y sus expectativas; y, discutir la ayuda de enfermería recibida en una maternidad pública de Teresina Piauí (Brasil. La metodología usada fué el un formulario medio estructurado cuya colecta de datos fué hecha a través de la entrevista. Los resultados fueron presentados en categorías que evidenciaban como razones más comunes que llevaran las 12 mujeres a internación: edema y dolor de cabeza crónica. La ayuda de enfermería prestada fue limitada a la verificación de la presión arterial y administración de medicina. Cuánto a la satisfacción fué mencionada la realización de los procedimientos

  10. Management of preeclampsia.

    Science.gov (United States)

    Dekker, Gustaaf Albert

    2014-07-01

    Most patients with a pregnancy-induced hypertensive disorder have no clinical symptoms. So it can only be reliably detected by repetitive searches (screening) for the early signs and symptoms in the 2nd half of pregnancy. Adequate and proper prenatal care is the most important part of management of preeclampsia. Maternal antenatal monitoring includes identifying women at increased risk, early detection of preeclampsia by recognizing clinical signs and symptoms, and to observe progression of the condition to the severe state. As the etiology of preeclampsia remains in question, the only effective treatment is to deliver the infant and placenta; ancillary therapy is predominantly symptomatic and not directed at underlying causes. Once the diagnosis of preeclampsia is made, subsequent therapy will depend on the results of initial maternal and fetal evaluation. The primary objective of management of preeclampsia must always be safety of the mother. Although delivery is always appropriate for the mother, it may not be optimal for the fetus that is extremely premature. The decision between delivery and expectant management depends on fetal gestational age, maternal and fetal status at time of initial evaluation, presence of labor or rupture of fetal membranes, and level of available neonatal and maternal services. It is important to emphasize that hypertension is merely one manifestation of this disease, albeit directly related to one of the most serious consequences for the mother, i.e cerebral involvement, which may manifest itself as convulsions, focal neurological events such as cortical blindness, and even cerebral hemorrhage. The benefits of acute pharmacologic control of severe hypertension prior to delivery are generally accepted. The more contentious issues are the role of pharmacologic therapy in allowing prolongation of pregnancy and the ability of such therapy to modify the course of the underlying systemic disorder and affect fetal and maternal outcome. Ali

  11. El impacto de la crisis en la relación entre vivienda y salud. Políticas de buenas prácticas para reducir las desigualdades en salud asociadas con las condiciones de vivienda

    Directory of Open Access Journals (Sweden)

    Ana M. Novoa

    2014-06-01

    Full Text Available Las condiciones de vivienda pueden repercutir sobre la salud física y mental a través de cuatro dimensiones interrelacionadas: 1 el hogar (condiciones emocionales relacionadas con la vivienda, 2 las condiciones físicas de la vivienda, 3 el entorno físico y 4 el entorno social (comunidad del barrio donde está situada la vivienda. En España, la utilización del mercado de la construcción como motor de crecimiento económico del país y la promoción de la propiedad privada como régimen de tenencia mayoritario han comportado que la vivienda sea utilizada como bien especulativo en lugar de ser considerada un bien de primera necesidad. Mientras España es el país de la Organización para la Cooperación y el Desarrollo Económicos (OCDE con el mayor parque de viviendas por habitante, éste se encuentra altamente infrautilizado y la población con menos recursos queda excluida del acceso a la vivienda. El impacto de la actual crisis económica sobre la vivienda se ha debido sobre todo a la reducción de los ingresos de los hogares, con el consecuente aumento del número de familias o personas con problemas para afrontar los gastos de la vivienda o desahuciadas. Existe evidencia de que estos problemas tienen un impacto negativo en la salud, en especial en la salud mental, pero también las dificultades económicas para satisfacer otras necesidades básicas como la alimentación. Existen distintos instrumentos para reducir el impacto de la crisis económica, como la financiación de la deuda o la dación en pago. A largo plazo, debería promoverse la creación de un parque de vivienda social y sistemas de ayudas al pago del alquiler.

  12. Pancreatitis aguda recidivante con enteropatía por gluten asociada: Características clínico-analíticas y evolutivas en 34 pacientes Relapsing acute pancreatitis associated with gluten enteropathy: Clinical, laboratory, and evolutive characteristics in thirty-four patients

    Directory of Open Access Journals (Sweden)

    L. Rodrigo

    2008-12-01

    Full Text Available Objetivos: describir la frecuencia y características clínico-analíticas de la pancreatitis aguda (PA recidivante con enteropatía por gluten (EG asociada. Pacientes y métodos: estudiamos de forma prospectiva los casos de pancreatitis agudas ingresados en nuestro Servicio durante el año 2006. Registramos un total de 185 pacientes. A las formas recurrentes que fueron 40 en total (22%, les aplicamos un protocolo clínico-analítico consistente en la determinación de marcadores serológicos, genéticos y biopsias duodenales, para descartar una EG asociada. Resultados: un total de 34 pacientes (18% cumplían criterios clínico-biológicos de EG asociada (grupo 1 y se compararon con el resto de las PA no-EG (n = 161 (grupo 2. La edad media en la EG fue de 54 ± 25 años, ligeramente inferior al grupo 2, (61 ± 14 (NS. Existía un ligero predominio de mujeres (50% en el grupo 1, respecto al grupo 2 (38,5% (NS. Siete pacientes del grupo 1 (20% presentaron una PA grave, frente a 27 (17% en el grupo 2 (NS. La presencia de colelitiasis en el grupo 1, fue de 6 casos (18%, significativamente inferior a la del grupo 2, de 72 casos (45% (p Objectives: to describe the frequency and the clinical and laboratory characteristics of relapsing acute pancreatitis (AP associated with gluten enteropathy (GE. Patients and methods: we prospectively examined all acute pancreatitis cases admitted to our Department in 2006. We recorded a total of 185 patients. With recurring forms, 40 (22% in all, we used a clinical-lab protocol including serologic and genetic markers, and duodenal biopsy to rule out GE. Results: a total of 34 patients (18% met clinical-biological criteria for GE (group 1, and were compared to the remaining non-GE AP cases (n = 161 (group 2. Mean age in the GE group was 54 ± 25 years, slightly younger than group 2 (61 ± 14 (NS. There was a mild predominance of women (50% in group 1 versus group 2 (38.5% (NS. Seven patients in group 1 (20% had severe

  13. Maternal Preeclampsia and Neonatal Outcomes

    Directory of Open Access Journals (Sweden)

    Carl H. Backes

    2011-01-01

    Full Text Available Preeclampsia is a multiorgan, heterogeneous disorder of pregnancy associated with significant maternal and neonatal morbidity and mortality. Optimal strategies in the care of the women with preeclampsia have not been fully elucidated, leaving physicians with incomplete data to guide their clinical decision making. Because preeclampsia is a progressive disorder, in some circumstances, delivery is needed to halt the progression to the benefit of the mother and fetus. However, the need for premature delivery has adverse effects on important neonatal outcomes not limited to the most premature infants. Late-preterm infants account for approximately two thirds of all preterm deliveries and are at significant risk for morbidity and mortality. Reviewed is the current literature in the diagnosis and obstetrical management of preeclampsia, the outcomes of late-preterm infants, and potential strategies to optimize fetal outcomes in pregnancies complicated by preeclampsia.

  14. Enfermedad de Jacob asociada con el síndrome de disfunción de la articulación temporomandibular: presentación de un caso

    OpenAIRE

    Capote, Ana; Rodríguez, Francisco J.; Blasco, Ana; Muñoz, Mario F.

    2005-01-01

    La enfermedad de Jacob se describe como una entidad infrecuente en la cual se establece una formación articular sinovial entre una apófisis coronoide mandibular elongada y el hueso malar homolateral. El Síndrome de disfunción de la articulación temporomandibular (ATM) ha sido postulado como posible factor etiológico del alargamiento este proceso coronoideo. Presentamos el caso de una mujer de 23 años con un desplazamiento discal de ATM de larga evolución y limitación de l...

  15. Frecuencia de infección por virus sincitial respiratorio y virus influenza y su relación con características clínico-radiológicas y sociodemográficas asociadas

    OpenAIRE

    Diaz Martínez, Ines; Gaviria Diaz, Alicia

    2015-01-01

    Tesis (Magíster en Microbiología Clínica).-- Universidad de San Buenaventura, Facultad de Ciencias de la Salud, Programa de Bacteriología, 2014 La presente investigación está enmarcada en un diseño de cohortes retrospectivas, pareadas por edad, en el cual se estimará la asociación de algunas condiciones clínicas, radiológicas y sociodemográficas con las infecciones por virus Influenza y virus Sincitial Respiratorio en pacientes menores de 15 años, atendidos en la Fundación Hospita...

  16. Urbanizing the wild: shifts in bird communities associated to small human settlements Urbanizando la naturaleza: cambios en las comunidades de aves asociadas con asentamientos humanos pequeños

    Directory of Open Access Journals (Sweden)

    Ian MacGregor-Fors

    2012-06-01

    Full Text Available Urbanization limits the number and type of species that can colonize urban environments. As habitat change and large abundances of urban exploiter species have been related to changes in urban bird communities, we evaluated shifts in the bird communities in 2 small sized settlements, 1 with exploiter species and one without them. Our results show that bird species richness decreases when an area becomes urbanized, regardless of the presence of urban exploiters. While bird densities were low in the human settlement lacking urban exploiters, they were high in the other settlement due to the numbers of 2 urban exploiter species. Bird community evenness decreased from forests to the human settlement lacking urban exploiters, while decreased importantly in the settlement dominated by urban exploiters. The composition of bird communities was highly similar between forest conditions and the settlement lacking urban exploiters, and highly different to that from the settlement with urban exploiters. Our results thus suggest that when an area becomes urbanized, changes in habitat structure and their subsequent invasion by urban exploiter species generate a significant loss in bird species richness, favoring those species that can inhabit and exploit the new urban condition.La urbanización limita el número y tipo de especies que pueden colonizar a los ambientes urbanos. Debido a que los cambios de hábitat y las elevadas abundancias de especies explotadoras de ambientes urbanos han sido relacionadas con cambios en las comunidades de aves, en este trabajo evaluamos los cambios en las comunidades de aves en dos asentamientos humanos pequeños, uno con especies explotadoras y otro sin ellas. Nuestros resultados muestran que la riqueza de especies de aves disminuye cuando un área es urbanizada, sin importar la presencia de especies explotadoras. Las densidades de aves fueron bajas en asentamientos humanos sin especies explotadoras y fueron

  17. Variabilidad interdiaria de la precipitación en Medellín (Colombia) asociada con las ondas tropicales del este y su comportamiento durante las fases del ENSO.

    OpenAIRE

    Salas Parra, Hernán Darío; Carmona Duque, Alejandra María; Poveda Jaramillo, Germán

    2012-01-01

    El sistema ENSO y las Ondas Tropicales del Este se encuentran entre los factores que ayudan a explicar las anomalías hidrológicas en Colombia. En el presente trabajo se implementan la Transformada en Onditas y la Transformada de Hilbert-Huang al estudio de series de lluvia diaria en los Andes Tropicales de Colombia con el fin de estudiar la influencia de las Ondas Tropicales del Este en la precipitación para diferentes fases del ENSO. Se analizan los dos años más fuertes de cada fase del sist...

  18. Estudio de la respuesta inmune en mujeres asociada a la implantación de prótesis mamaria con cápsula periprotésica de silicona

    OpenAIRE

    Contell Villagrasa, Antonio

    2015-01-01

    El implante quirúrgico de prótesis mamarias con cápsula periprotésica de silicona, en cirugía reconstructiva o por motivos estéticos, viene realizándose desde hace más de cinco décadas. Pese a ser considerados seguros, en algunas pacientes sometidas a estos implantes, sin embargo, se ha descrito un grupo de síntomas similares a los observados en enfermedades del tejido conectivo como artritis reumatoide, lupus eritematoso sistémico o polimiositis. Hasta la fecha, las secuelas inmunológicas no...

  19. Dificultades asociadas al aprendizaje del álgebra lineal en entornos mediados tecnológicamente. Experiencia con profesores de matemáticas en formación inicial

    OpenAIRE

    Herrera, Mariela Lilibeth; González, Andrés

    2011-01-01

    El propósito de la investigación fue indagar las dificultades de los profesores de matemática en formación inicial en el aprendizaje del álgebra lineal apoyado en un entorno virtual. En el marco teórico se considera la teoría de dificultades de Socas (1997), el concepto de pensamiento algebraico así como aspectos teóricos y prácticos relacionados con la mediación tecnológica del aprendizaje. Se empleó un enfoque cualitativo, el grupo focal lo constituyó un curso de “introducción al Álgebra li...

  20. Mortalidad asociada con la contaminación atmosférica por SO2: A propósito de un caso de autopsia médico legal tras un episodio de polución atmosférica Mortality associated with atmospheric pollution by SO2: A medical legal case of autopsy after an episode of atmospheric pollution

    Directory of Open Access Journals (Sweden)

    P.M. Garamendi González

    2003-07-01

    Full Text Available Se presenta un caso de muerte súbita de origen respiratorio en un paciente afecto de broncopatía previa en el entorno de un episodio de contaminación atmosférica por SO2. Se exponen los resultados del estudio histopatológico y toxicológico, así como las conclusiones de las encuestas clínicas en la población expuesta y de los análisis de concentraciones ambientales por SO2 durante el episodio. Se presentan los datos de revisión bibliográfica sobre la mortalidad asociada con exposición ambiental al SO2. Se analizan los criterios de causalidad de la posible muerte relacionada con la exposición a tóxicos y se valoran los posibles factores de confusión en la interpretación de los resultados del estudio forense.We present a case report on a sudden pulmonary death in an asthmatic subject exposed to sulphur dioxide air pollution. We present the results of histopathological and toxicological investigations and those of the epidemiological survey on the general population exposed to a sulphur dioxide pollution episode. Air concentrations of sulphur dioxide during the pollution episode are summarised. We also developed a short bibliographic review on sudden death associated with sulphur dioxide pollution. Finally, we analyse causality criteria about the relationship between sudden death in this case and the sulphur dioxide exposure episode and we point out some possible misinterpretation factors related to forensic evaluation of the episode and its relation with sudden death.

  1. Características de la caña de azúcar asociadas con toneladas de caña por hectárea y sacarosa (% caña

    Directory of Open Access Journals (Sweden)

    Carlos Arturo Viveros Valens

    2015-07-01

    Full Text Available En las etapas iníciales del proceso de selección clonal en caña de azúcar (Saccharum spp. se realiza la selección indirecta para las variables toneladas de caña por hectárea (TCH y porcentaje de sacarosa. Esta selección indirecta puede aumentar su eficiencia en la medida que se precise mejor el conocimiento acerca de la naturaleza y la magnitud de las asociaciones existentes entre las características de interés y entre éstas y los indicadores de productividad. El objetivo del presente trabajo fue estimar las correlaciones genéticas entre las variables de tipo agronómico (factores causales y las de rendimiento (variables de respuesta, además descomponer su magnitud mediante análisis de sendero. Se evaluaron cinco caracteres de interés en caña de azúcar (altura, diámetro de tallos, población de tallos por metro, TCH y sacarosa (% caña en cinco localidades de la zona semiseca del valle del río Cauca para 17 variedades y dos testigos (CC 85-92 y MZC 74-275 en plantilla utilizando un diseño experimental Latice. Para estimar los coeficientes de correlación genética y de sendero (‘path coefficient’ se utilizó el software GENES. El análisis mostró que para obtener variedades con alto TCH y alta sacarosa (% caña, primero se deben seleccionar clones con altura superior que la variedad testigo CC 85-92 (334 cm para asegurar un contenido alto de sacarosa y posteriormente hacer un segundo tamizado por tallos gruesos de diámetro mayor que el testigo (32 mm y alta población de tallos igual o superiores que el testigo (14 tallos/m

  2. Efecto de la calidad de la materia orgánica asociada con el uso y manejo de suelos en la retención de cadmio, en sistemas altoandinos de Colombia

    Directory of Open Access Journals (Sweden)

    Isabel del Socorro Bravo Realpe

    2014-04-01

    Full Text Available El cadmio (Cd proveniente de suelos afectados por intemperismo y actividades antropogénicas puede producir efectos tóxicos, asociados con la baja afinidad de las formas adsorbentes, la alta solubilidad y la movilidad. Es de gran importancia conocer los fenómenos de adsorción y los factores de movilidad de este elemento y predecir su posible toxicidad en suelos de la región altoandina de Colombia cuyo sistema de uso está cambiando a pasturas y cultivos con aplicación de fertilizantes fosfatados que contienen cadmio. Para determinar la influencia en la retención y el factor de movilidad de Cd en estos suelos de la subcuenca Rio Las Piedras, Departamento del Cauca (Colombia, utilizados en sistemas de bosque, cultivo de papa (Solanum tuberosum y pastura de kikuyo (Pennisetum clandestinum fueron caracterizados por sus propiedades físicas y químicas, encontrando alta acidez, presencia de alófanos, alto contenido de carbono orgánico, alta capacidad de intercambio catiónico, y baja densidad. Para determinar la influencia en la retención y el factor de movilidad de cadmio, la calidad de la materia orgánica (M.O fue evaluada mediante índices de humificación obtenidos por la caracterización de sus diferentes fracciones. La retención fue evaluada mediante isotermas de adsorción de Freundlich en ácidos húmicos en suelos de los tres sistemas de uso. Los valores encontrados de K (máxima capacidad de adsorción y n (fuerza de retención fueron, respectivamente, de 131.98 y 1.18 en suelos de bosque, 340.93 y 1.19 en cultivo, y 170.36 y 1.19 en pasturas. La calidad de la M.O. tiene un efecto significativo en estos procesos, así, una mejor calidad redunda en menor movilidad de cadmio, previniendo contaminación de aguas subterráneas y toxicidad por bioacumulación de cadmio.

  3. Insulinorresistencia asociada a cambios en los niveles de tirotrofina en pacientes eutiroideos o con disfunción tiroidea subclínica Insulin Resistance and Changes in thyrotropin levels in patients with euthyroidism or subclinic thyroid dysfunction

    Directory of Open Access Journals (Sweden)

    JD Herrera

    2012-12-01

    Full Text Available La relación entre síndrome metabólico y disfunción tiroidea subclínica es un tema aun controvertido. Por tal motivo, el objetivo principal de nuestro trabajo fue tratar de establecer la existencia de una asociación entre la insulinorresistencia medida por el HOMA-IR (Homeostasis Model Assessment con los niveles de TSH en pacientes eutiroideos o con disfunción tiroidea subclínica. A su vez, y en forma secundaria, se valoraron cambios en el perfil lipídico. Se analizaron los niveles de T4L, TSH, insulina, glucemia, colesterol total, HDL colesterol, triglicéridos e índice de masa corporal en 233 pacientes eutiroideos o con disfunción tiroidea subclínica y se dividieron en tres grupos según su nivel de TSH: Grupo A: TSH de 2,5 mUI/L. Encontramos que, los niveles de insulina y el HOMA-IR en el grupo B fueron significativamente menores que en el grupo C (7,91 ± 0,67 mUI/L vs. 10,23 ± 0,91 mUI/L - p = 0,0073 y 1,84 ± 0,17 vs. 2,49 ± 0,27 - p = 0,0113, respectivamente. Esta diferencia fue independiente de la edad y del IMC. Además, se encontró una leve pero significativa disminución de los niveles de HDL-colesterol en el grupo C respecto al B (48,3 ± 0,5 vs. 46,3± 0,7 mg/dl; p = 0,0455 y un incremento de los triglicéridos (146,9 ± 11,9 vs. 112,3 ± 5,6 mg/dl; p = 0,0162. La prevalencia de insulinorresistencia definida como un valor de HOMA-IR > de 2,5 fue superior en el grupo C comparado con el B (39,5 % vs. 23,9 %; OR de 2,06 - IC 95 %: 1,19-3,63 - p = 0,013. Por último, se observó una débil pero significativa correlación negativa entre HOMA-IR y T4L (r - 0,2336; p = 0,0047 y positiva entre HOMA-IR y TSH (r = 0,1909; p = 0,0066 en toda la cohorte analizada. Concluimos que en la población analizada, los pacientes con TSH > de 2,5 mUI/L presentaron: a niveles de HDL colesterol más bajos, b triglicéridos y HOMA-IR más elevados, independientemente de la edad y del IMC, y c un aumento significativo del riesgo de tener

  4. Mutaciones asociadas con resistencia a rifampicina o isoniazida en aislamientos clínicos de M. tuberculosis de Sonora, México DNA mutations associated to rifampicin or isoniazid resistance in M. tuberculosis clinical isolates from Sonora, Mexico

    Directory of Open Access Journals (Sweden)

    Enrique Bolado-Martínez

    2012-04-01

    Full Text Available OBJETIVO: Realizar el análisis de regiones específicas de genes asociados con resistencia a isoniazida o rifampicina. MATERIAL Y MÉTODOS: Se estudiaron 22 cepas de M. tuberculosis, aisladas en Sonora, México. Se utilizaron iniciadores para regiones específicas de los genes rpoB, katG e inhA y la región ahpC-oxyR. Los productos de PCR se secuenciaron y analizaron. RESULTADOS: Se identificaron mutaciones en la región promotora del gen inhA, región ahpC-oxyR, codón 315 del gen katG y codones 451 ó 456 del gen rpoB. CONCLUSIONES: La identificación de mutaciones no descritas previamente obliga a continuar el análisis genotípico de cepas aisladas en Sonora.OBJECTIVE: To perform the analysis of specific regions of the major genes associated with resistance to isoniazid or rifampin. MATERIALS AND METHODS: Twenty two M. tuberculosis strains, isolated from human samples obtained in Sonora, Mexico. Specific primers for hotspots of the rpoB, katG, inhA genes and the ahpC-oxyR intergenic region were used. The purified PCR products were sequenced. RESULTS: Mutations in the promoter of inhA, the ahpC-oxyR region, and codon 315 of katG and in 451 or 456 codons of rpoB, were identified. CONCLUSIONS: Detection of mutations not previously reported requires further genotypic analysis of Mycobacterium tuberculosis isolates in Sonora.

  5. ENFERMEDAD RENAL POLIQUISTICA ASOCIADA A LINFOMA EXTRANODAL EN UN CANINO

    Directory of Open Access Journals (Sweden)

    Diego Echeverry B

    2006-12-01

    Full Text Available Objetivo: Presentar el caso de un paciente canino, con enfermedad renal poliquística, asociada alinfoma extranodal. Materiales y métodos: Se estudió el caso de un paciente canino de raza SiberianHusky de 7 años de edad, al que se le encontraron múltiples nódulos renales bilaterales, condiagnóstico histopatológico de linfoma extranodal. Resultados: Se expone el caso clínico de unpaciente canino de raza Siberian Husky, que es presentado a consulta dermatológica por exhibirlesiones alopécicas multifocales. Una vez realizado el examen físico sistemático se evidenció demanera incidental nefromegalia. Los exámenes paraclínicos e histopatológicos aplicadosdemostraron la presencia de enfermedad renal poliquística asociada a linfoma extranodal, comoconsecuencia se presento falla renal crónica. Conclusiones: El linfoma extranodal renal es unaentidad patológica de rara presentación, clínicamente cursa con signos muy similares a otrasalteraciones tumorales, su diagnóstico suele ser histopatológico.

  6. Manejo de la salinidad en aguas asociadas de producción de la industria petrolera.

    OpenAIRE

    Guerrero Fajardo, Carlos Alberto; Escobar C, Sandra; Ramírez N, Diego

    2010-01-01

    En este artIculo se presenta el diseno conceptual de una alternativa complementaria de la solución al manelo de las aguas asociadas de producción dentro de un marco ambiental y técnico factible, cuyo fin es la recuperación de la sal de mayor porcentale, mediante un proceso de cristalización fraccionada tipo I.Para plantear y analizar la alternativa de trabalo con las aguas asociadas de producción provenientes de las estaciones La Gloria, La Gloria Norte y Morichal, pertenecientes a la Asociac...

  7. Queratodermia palmoplantar asociada a Hipotiroidismo Acquired palmoplantar keratoderma with hypothyroidism

    Directory of Open Access Journals (Sweden)

    María Dolores Salduna

    2005-03-01

    Full Text Available Describimos un paciente de 45 años de sexo masculino, con hiperqueratosis palmoplantar. Simultáneamente se diagnosticó hipotiroidismo primario de origen autoinmune. Al realizar tratamiento sustitutivo con levotiroxina, el cuadro dermatológico se resolvió en el transcurso de siete meses. La queratodermia palmoplantar adquirida asociada a hipotiroidismo es una condición reversible. A pesar de ser una asociación infrecuente, debe ser considerada en el diagnóstico diferencial.We report the case of a 45 year-old male with palmoplantar hyperkeratosis. He had chronic thyroiditis with severe hypothyroidism. Skin lesions improved upon thyroid hormone replacement. Complete resolution of palmoplantar keratoderma was achieved after 7 months of therapy. The association of acquired palmoplantar keratoderma with hypothyroidism even though extremely unusual, should be considered in the differential diagnosis. It is a reversible condition.

  8. Osteonecrosis maxilar asociada a bifosfonatos

    OpenAIRE

    Argüello, M. C.; Bonifaci, J.; Quintana Toulouse, J. I.; E. Ibáñez

    2015-01-01

    Los bifosfonatos (BF) son un grupo de medicamentos, análogos sintéticos de la hidroxiapatita, que reducen la velocidad de recambio óseo, inhibiendo la reabsorción, principalmente mediante la inhibición de la acción de los osteoclastos. Se utilizan en pacientes con enfermedades oncológicas y en patología reumatológica. Objetivos: informar a los profesionales de la salud sobre la problemática, dar a conocer el protocolo de trabajo planteado por la AAOMS (Asociación Americana de cirujanos Orales...

  9. Maternal and umbilical homocysteine in preeclampsia

    OpenAIRE

    Vuković Bobić, Mirna; Čerkez Habek, Jasna; Habek, Dubravko

    2016-01-01

    Background and purpose: Were to assess the association between homocysteine levels and development of preeclampsia, to determine homocysteine levels in fetal circulation, to differentiate homocysteine levels in mild and severe preeclampsia and to compare homocysteine levels in pregnant women with preeclampsia with homocysteine levels measured in the same group of women six months after delivery. Material and methods: The study included 55 pregnant women with mild or severe preeclampsia (h...

  10. Cytomegalovirus Infection and Pre-Eclampsia

    OpenAIRE

    Rădulescu Carmen; Huţanu Adina; Gabor Rozalia; Şincu Nina

    2016-01-01

    Introduction: Pre-eclampsia is a pregnancy-specific disease characterized by hypertension after 20 weeks of gestation and proteinuria. It is a major cause of maternal and perinatal morbidity and mortality. The pathogenesis of pre-eclampsia is not completely understood. In our study we investigated if there is a potential link between cytomegalovirus infection and pre-eclampsia and if cytomegalovirus infection is the triggering factor of pre-eclampsia.

  11. C-reactive protein and later preeclampsia

    DEFF Research Database (Denmark)

    Rebelo, Fernanda; Schlüssel, Michael M; Vaz, Juliana S;

    2013-01-01

    This study aims to determine whether high C-reactive protein (CRP) concentration during pregnancy is associated with later preeclampsia and whether weight status (BMI) is a potential modifier of the relation between CRP and preeclampsia.......This study aims to determine whether high C-reactive protein (CRP) concentration during pregnancy is associated with later preeclampsia and whether weight status (BMI) is a potential modifier of the relation between CRP and preeclampsia....

  12. Cytomegalovirus Infection and Pre-Eclampsia

    Directory of Open Access Journals (Sweden)

    Rădulescu Carmen

    2016-06-01

    Full Text Available Introduction: Pre-eclampsia is a pregnancy-specific disease characterized by hypertension after 20 weeks of gestation and proteinuria. It is a major cause of maternal and perinatal morbidity and mortality. The pathogenesis of pre-eclampsia is not completely understood. In our study we investigated if there is a potential link between cytomegalovirus infection and pre-eclampsia and if cytomegalovirus infection is the triggering factor of pre-eclampsia.

  13. Neuroplasticidad asociada a miembro fantasma

    Directory of Open Access Journals (Sweden)

    R. de la Puerta Huertas

    2014-12-01

    Full Text Available En las últimas décadas, el concepto de neuroplasticidad ha tomado clara relevancia asociado a la salud del paciente y al aprendizaje y conducta en el individuo sano. Esta capacidad del sistema nervioso implica asimilación, reorganización y modificación de nuestro mecanismo biológico, bioquímico y fisiológico. Con el advenimiento de nuevas tecnologías científicas que han aparecido en los últimos años, respondemos y mantenemos a este concepto de plasticidad del sistema nervioso como premisa base de ser susceptible a cambios externos y dinámicos. La experiencia del miembro fantasma pone al descubierto, de forma permanente, la existencia de un mapa corporal mental que subyace y modifica la experiencia con nuestro cuerpo, cuyo sistema nervioso posee la capacidad de reorganización cortical por estimulación sensitiva, sensorial, endocrina y motora. La relación entre miembro fantasma y neuroplasticidad es compleja, difícil de investigar a pesar de los avances científicos obtenidos y, a la vez, es dinámica, ya que esta capacidad responde a las necesidades de salud en el ser humano en las diferentes etapas de su vida.

  14. Uso de filtros de Bangerter para el tratamiento de la ambliopía leve o moderada asociada a estrabismo

    OpenAIRE

    Laria Ochaíta, Carlos; Piñero Llorens, David Pablo

    2013-01-01

    Objetivo: Evaluar los resultados obtenidos mediante el empleo de los filtros de Bangerter en casos de ambliopía media o moderada asociada a estrabismo. Material y métodos: Se realizó un estudio prospectivo con 30 pacientes de edades comprendidas entre 2 y 9 años con ambliopía media o moderada unilateral asociada a estrabismo. Todos los pacientes fueron tratados mediante la prescripción del empleo de filtros de Bangerter en el ojo no ambliope junto a su corrección refractiva. En todos los caso...

  15. Representações sociais sobre a alimentação por sonda obtidas de pacientes adultos hospitalizados Representaciones sociales asociadas con la nutrición por sondas en pacientes hospitalizados Social representations associated with tube feeding among adult hospitalized patients

    Directory of Open Access Journals (Sweden)

    Jaqueline Almeida Guimarães Barbosa

    2005-04-01

    Full Text Available Identificar e compreender as representações de pacientes sobre alimentação por sonda. Entrevista aberta com 16 pacientes em uso de sondas para alimentação. A análise das entrevistas foi fundamentada na análise de discurso. O referencial teórico adotado foi a Teoria das Representações Sociais. Identificou-se a existência de uma trajetória, na qual as representações vão sendo reorganizadas e reconstruídas pela experiência, para tornar tolerável esse tratamento, começando quando o paciente se depara com a necessidade do uso, passando pela experiência do uso e, finalmente, tendo que se decidir pela continuidade ou não do uso no ambiente domiciliar. Dentre as representações encontradas, existem algumas que contribuem para a adesão e outras para a rejeição a esse tratamento. Conhecendo as idéias e crenças positivas e negativas sobre esse tratamento, torna-se possível atuar de forma mais direcionada a fim de aumentar a adesão ao tratamento e satisfação com ele.La finalidad fue identificar y comprender las representaciones asociadas con la nutrición por sondas en pacientes hospitalizados. Fueron realizadas entrevistas con 16 pacientes en uso de sondas para nutrición enteral. El análisis de las entrevistas tuvo como base el análisis del discurso y la Teoría de Representación Social. Fue identificada una secuencia en que las representaciones son reorganizadas y reconstruidas por la experiencia, para hacer el tratamiento tolerable. Esta secuencia se inicia cuando el paciente tiene que enfrentar la necesidad del uso de la sonda, seguida por la experiencia de su uso y, finalmente, cuando tiene que decidir sobre la permanencia o no de la sonda cuando se va al hogar. Entre las representaciones encontradas existen algunas que contribuyen para la adhesión y otras para su rechazo. Con base en las representaciones identificadas, es posible actuar de manera mas dirigida para aumentar la adhesión y satisfacción con el

  16. Immunology and Genetic of Preeclampsia

    Directory of Open Access Journals (Sweden)

    Norma C. Serrano

    2006-01-01

    Full Text Available Preeclampsia is a disease characterized by hypertension and proteinuria in the third trimester of pregnancy. Preeclampsia is a major cause of maternal mortality, and fetal death, especially in developing countries, but its aetiology remains unclear. Key findings support a causal role of superficial placentation driven by immune mal maladaptation, which then lead to reduced concentrations of angiogenic growth factors and to an increase in placental debris in the maternal circulation resulting in a maternal inflammatory response. Epidemiological research has consistently demonstrated a substantial familial predisposition to preeclampsia. Unfortunately, the conquest of the genes explaining such a individual susceptibility has been proved to be a hard task. However, genetics will also inform us about causality of environmental factors, and then serve as a tool to prioritize therapeutic targets for preventive strategies.

  17. Incidencia de infección asociada a catéter y factores de riesgo relacionados en pacientes hospitalizados con nutrición parenteral Incidence of catheter-related infection and associated risk factors in hospitalized patients with parenteral nutrition

    Directory of Open Access Journals (Sweden)

    M.ª J. Aguilella Vizcaíno

    2012-06-01

    Full Text Available Introducción: La complicación más grave de la nutrición parenteral (NPT es la infección asociada a catéter (IAC. Objetivos: Estudiar la tasa de incidencia y los factores asociados a IAC. Material y métodos: 271 pacientes seguidos por la Unidad de Nutrición durante seis meses. La composición de la NPT se calculaba de acuerdo a las necesidades metabólicas. Un 20,3% recibió la solución lipídica enriquecida con ácidos grasos omega3 (SMOF Fresenius Kabi® y un 79,7% con aceite de oliva (Clinoleic Baxter®. Resultados: La tasa de IAC fue de 25 por 1.000 días de NPT (55 pacientes: 61,7 ± 17,8 años, 60,3% hombres, 29,3 ± 10,6 días de estancia y 10,4% mortalidad. El Staphiloccocus coagulasa negativo fue el germen aislado más frecuente. No existían diferencias en la edad, sexo, mortalidad y composición de la NPT entre pacientes con y sin infección. Los pacientes tratados con omega-3 recibían más calorías en la NPT, a expensas de mayor aporte de glucosa y de lípidos. Sin embargo, la frecuencia de infección era similar, aunque existía una tendencia no significativa a ser menor con el uso de omega-3 (14,5% vs 23,1% respectivamente, p = 0,112. La duración del soporte nutricional fue mayor en los enfermos con IAC (13,0 ± 9,7 vs 9,3 ± 8,1, p = 0,038. La mortalidad total (16,9% fue independiente de si el paciente presentaba o no IAC (10,4% vs 18,7%, p = 0,090 o del uso de lípidos omega3 o aceite de oliva en la NPT (10,9% vs 18,5%, p = 0,125. Conclusión: Los pacientes sometidos a NPT cursan con una tasa elevada de IAC. La presencia de infección se relaciona con la duración de la NPT, siendo independiente de la edad, sexo y composición de la solución. El uso de soluciones lipídicas con omega-3 podría ser beneficiosa, aunque se necesitan más estudios para su confirmación.Introduction: The most severe complication of parenteral nutrition (PTN is catheter-related infection (CRI. Objectives: To study the incidence rate and

  18. Incremento en la prevalencia del VIH y en las conductas de riesgo asociadas en hombres que tienen sexo con hombres: 12 años de encuestas de vigilancia conductual en Cataluña Increase in the prevalence of HIV and in associated risk behaviors in men who have sex with men: 12 years of behavioral surveillance surveys in Catalonia (Spain

    Directory of Open Access Journals (Sweden)

    Cinta Folch

    2010-01-01

    Full Text Available Objetivos: Describir las tendencias en la prevalencia de la infección por VIH, las conductas de riesgo asociadas a su transmisión y las actitudes respecto a los tratamientos antirretrovirales en el colectivo de hombres que tienen sexo con hombres reclutados en Cataluña entre 1995 y 2006. Métodos: Estudios transversales bianuales en una muestra de conveniencia de hombres que tienen sexo con hombres reclutados en saunas, sex-shops, bares y un parque público, y por correo a los socios de la Coordinadora Gai-Lesbiana, mediante un cuestionario anónimo y autoadministrado. Se recogieron muestras de saliva para determinar la prevalencia de la infección por VIH. La significación de las tendencias lineales en las proporciones se analizó mediante el test de ji² de tendencia lineal, estratificando por edad. Resultados: La prevalencia global del VIH aumentó del 8,5% (1995 al 14,1% (2006 en los menores de 30 años (p=0,162, y del 18,2% (1995 al 21,2% (2006 en los de 30 años y más (p=0,07. El uso consistente del preservativo en la penetración anal con parejas ocasionales descendió del 72,9% al 58,7% en los menores de 30 años (pObjectives: To describe trends in HIV prevalence, in risk behaviors associated with HIV transmission, and in knowledge and attitudes related to antiretroviral therapy (ART among men who have sex with men (MSM recruited in Catalonia between 1995 and 2006. Methods: Biannual cross-sectional surveys were performed. An opportunistic sample of MSM was recruited in saunas, sex shops, bars and a cruising site in a public park. In addition, an anonymous self-administered questionnaire was sent by mail to all members of a gay and lesbian association (Coordinadora Gai-Lesbiana. Oral fluid samples were collected to determine HIV prevalence. Linear trends in proportions were assessed by the chi² test, stratified by age. Results: The overall prevalence of HIV infection increased from 8.5% (1995 to 14.1% (2006 among men aged less than

  19. Epigenetic Placental Programming of Preeclampsia

    Science.gov (United States)

    Preeclampsia (PE) affects 8-10% of women in the US and long-term consequences include subsequent development of maternal hypertension and hypertension in offspring. As methylation patterns are established during fetal life, we focused on epigenetic alterations in DNA methylation as a plausible expla...

  20. Update in pre-eclampsia.

    Science.gov (United States)

    Chanprapaph, Pharuhas

    2004-10-01

    Pre-eclampsia, formerly called pregnancy-induced hypertension, refers to the new onset of hypertension (SBP > or = 140 mmHg or DBP > or = 90 mmHg) and proteinuria (> or = 0.3 g protein in a 24-hour urine specimen or 1+ on dipstick) after 20 weeks of gestation in a previously normotensive women. It is a life-threatening, multi-organ involvement disease and remains the leading cause of maternal death. Its clinical manifestations are the result of generalized vasospasm, activation of the coagulation system, and changes in several humoral and autoregulatory systems related to volume and blood pressure control. Pre-eclampsia is responsible for high perinatal mortality and morbidity rates, primarily due to early termination of pregnancy. Fetus growth restriction, oligohyrdramnios and non-reassuring fetal status are the consequences of chronic placental hypoperfusion. Pre-eclampsia does not appear to accelerate fetal maturation, as once believed. Delivery remains the definitive treatment of choice for pre-eclampsia and should be timely. Cesarean section is not necessary and reserved for the obstetrical indications only. The expectant management may be considered for women remote from term (< 32 to 34 weeks of gestation) with stable and uncomplicated severe disease. The supportive management such as blood pressure control, seizure prevention, and fetal well-being assessment are also important to ensure the satisfactory outcome. To date, no screening test has been proved to be reliable and cost-effective. The prevention of pre-eclampsia with antioxidant therapy (vitamin C, E) has shown promise, but large, randomized trials are needed. Although controversy exists, calcium supplementation has shown no benefit in large trials, and most evidence suggests little or no benefit for low-dose aspirin as prevention in women in the low-risk category.

  1. Severe Preeclampsia: Characteristics and Consequences

    Directory of Open Access Journals (Sweden)

    Arturo Pérez de Villa Amil Álvarez

    2015-07-01

    Full Text Available Background: preeclampsia is a hypertensive disorder of pregnancy and a major cause of perinatal and maternal morbidity and mortality. Objective: to identify maternal and therapeutic factors as well as damage associated with severe preeclampsia in pregnant women. Method: a case series study was conducted in 69 patients diagnosed with severe preeclampsia treated at the Dr. Gustavo Aldereguía Lima University General Hospital from January 1, 2012 through December 31, 2013. They were divided into two groups according to presence of severe preeclampsia with and without aggravating factors. The variables analyzed were related to maternal characteristics, characteristics of medical care and fetal and neonatal characteristics. A questionnaire based on the data obtained from medical records was applied in line with the International Classification of Diseases, Tenth Revision. Comparisons between groups were performed using a chi-square statistic, considering a P<0.05 statically significant. Results: frequency of severe preeclampsia was 0.8 per 100 deliveries. The highest frequency occurred in the age range of 31-35 years. Eclampsia was observed in 0.91 per 1000 deliveries. Maternal damage amounted to 30.4%. Magnesium sulfate prophylaxis was used in 89% of cases. Eclampsia frequency when not used was 50%, while it was only 6.4% when this therapy was applied. Caesarean section was performed in 85.5% of patients. Neonatal damage was 52.3%. The late fetal death rate was 4.6 per 100 live births. Among the intergroup differences, significant dissimilarities were observed in neonatal damage. Conclusion: high association of intrauterine growth restriction with induced prematurity is evident as well as the high rate of first-time Caesarean sections and significant maternal, fetal and neonatal damage. The use of magnesium sulfate shows good results in the prophylaxis of eclampsia.

  2. Enzyme activity of superoxide dismutase and zincemia in women with preeclampsia.

    Science.gov (United States)

    Araújo Brito, José; do Nascimento Marreiro, Dilina; Moita Neto, José Machado; Michelle Costa e Silva, Danilla; Gonçalves de Sousa Almondes, Kaluce; Valadares Neto, João de Deus; do Nascimento Nogueira, Nadir

    2013-01-01

    Introducción: La preeclampsia es un síndrome de origen desconocido del punto de vista etiológico. Se caracteriza clínicamente por una tríada de síntomas: edema, hipertensión y proteinuria. Los conceptos actuales sobre la patogénesis de la preeclampsia incluyen la disfunción endotelial y el estrés oxidativo. Objetivo: En este estudio se evaluó la relación entre la actividad de la superóxido dismutasa, zincemia y preeclampsia. Métodos: Este estudio de casos y controles se llevó a cabo con 94 mujeres, con un rango de edad situado entre 17 y 44 AÑOs, los que fueron divididos en dos grupos: mujeres con preeclampsia (n = 44) y grupo control, las mujeres con embarazo normal (n = 50). La actividad de la superóxido dismutasa se llevó a cabo según el kit Ransod. Las concentraciones de zinc en plasma y los eritrocitos fue realizada según el metodo de espectrofotometría de absorción atómica de llama, ambos determinados antes del nacimiento y después del parto. La prueba de la t de Student y la prueba t pareada fue utilizada para el análisis estadístico (p eritrocitos, cuya concentración se mantuvo estable antes del parto y en el puerperio, en las mujeres con preeclampsia y en las con embarazo normal. La actividad antioxidante de la superóxido dismutasa, se encontró elevada en las mujeres con y sin preeclampsia (p > 0,05), con una reducción significativa en la actividad en el periodo postparto (p 0,05). Conclusiones: Este estudio revelló que hay cambios en los parámetros bioquímicos de zinc en mujeres con preeclampsia. La actividad de la superóxido dismutasa se revelló que este marcador no se puede utilizar para predecir la progresión de la enfermedad.

  3. What Are the Symptoms of Preeclampsia, Eclampsia, and HELLP Syndrome?

    Science.gov (United States)

    ... Resources and Publications What are the symptoms of preeclampsia, eclampsia, & HELLP syndrome? Skip sharing on social media links Share this: Page Content Preeclampsia Possible symptoms of preeclampsia include: High blood pressure ...

  4. What Are the Treatments for Preeclampsia, Eclampsia, and HELLP Syndrome?

    Science.gov (United States)

    ... for preeclampsia, eclampsia, & HELLP syndrome? Skip sharing on social media links Share this: Page Content Preeclampsia The only cure for preeclampsia when it occurs during pregnancy is delivering the fetus. Treatment decisions need to ...

  5. Inmunodetección de metaloproteinasas de matriz extracelular (MMPs-2, -9, -13 y -14 en lesiones apicales asociadas con periodontitis apical asintomática Immunodetection of matrix metalloproteinases (MMPs-2, -9, -13 and -14 in periapical lesions associated with asymptomatic apical periodontitis

    Directory of Open Access Journals (Sweden)

    V Mundi Burgos

    2011-04-01

    Full Text Available La periodontitis apical asintomática (PAa es una patología infecciosa caracterizada por destrucción ósea perirradicular asociada a un proceso inflamatorio crónico y producción de mediadores inflamatorios, entre los cuales se encuentran las metaloproteinasas de matriz extracelular (MMPs. Entre éstas, las MMPs-13, -14, -2 y -9, son producidas por el tejido óseo y degradan sinérgicamente el colágeno tipo I, principal componente de los tejidos periodontales, y gelatina, producto de la degradación y desnaturación del colágeno. El objetivo de este estudio fue determinar el patrón de expresión de las MMPs-2, -9, -13 y -14 en granulomas periapicales (GPAs, quistes radiculares inflamatorios (QRIs y ligamento periodontal sano (LS. Materiales y Métodos: Se seleccionaron 12 pacientes con diagnóstico clínico de PAa e indicación de exodoncia a partir de los cuales se obtuvieron biopsias de lesiones periapicales (LPAs. Como controles, se seleccionaron 7 individuos con indicación de exodoncia de premolares por ortodoncia, obteniéndose biopsias de LS. Se efectuó el diagnóstico anátomo-patológico de los especímenes y se caracterizó la expresión de las MMPs en estudio mediante inmunohistoquímica. Resultados: Las MMPs en estudio sólo se detectaron en GPAs y QRIs, y se inmunolocalizaron principalmente en el infiltrado inflamatorio de éstos. Adicionalmente, la MMP-2 se identificó en fibroblastos del tejido conectivo. Conclusiones: MMPs-2, -9, -13 y -14 se expresan predominantemente en el infiltrado inflamatorio de las LPAs y no en LS, y por tanto se sugiere la participación de estos mediadores en la patogénesis de la PAa.Asymptomatic apical periodontitis (aAP is an infectious disease characterized by perirradicular bone destruction associated with chronic inflammation and release of inflammatory mediators, such as matrix metalloproteinases (MMPs. MMPs-13, -14 and -2, -9 are bone-expressed enzymes that can synergistically degrade

  6. Effect of Periodontal Disease on Preeclampsia

    Directory of Open Access Journals (Sweden)

    F Sayar

    2011-09-01

    Full Text Available Background: A lot of studies have shown periodontal diseases as a risk factor for adverse pregnancy out­comes. The as­sociation between periodontitis and preeclampsia has been studied recently with contro­versy. Considering the importance of preventing preeclampsia as a dangerous and life-threatening disease in pregnant women, the pre­sent study was carried out. Methods: Two hundred and ten pregnant women participated in this case-control study (105 controls & 105 cases during years 2007 and 2008. Preeclamptic cases were defined as blood pressure ≥140/90mmHg and protein­uria +1. Control group were pregnant women with normal blood pressure with­out proteinuria. Both groups were examined during 48 hours after child delivery. Plaque Index (PLI, Pocket Depth (PD, Clinical Attachment Level (CAL, Bleeding On Probing (BOP, Gingival Recession (GR were measured on all teeth except for third molars and recorded as periodontal examination. Data was ana­lyzed using t-test, chi-square, and Mann-Whitney U statistical tests.Results: There was no significant difference between the two study groups for PD. CAL, GR, BOP signifi­cantly in­creased in the case group (P< 0.02. This study showed that preeclamptic cases were more likely to develop perio­dontal disease (P< 0.0001. Eighty three percent of the control group and 95% of the case group had perio­dontal disease (P< 0.005 which had shown that preeclamptic cases were 4.1 times more likely to have periodontal disease (OR= 4.1.Conclusion: Preeclamptic cases significantly had higher attachment loss and gingival recession than the con­trol group.

  7. Significance of maternal periodontal health in preeclampsia

    OpenAIRE

    Desai, Khushboo; Desai, Parth; Duseja, Shilpa; Kumar, Santosh; Mahendra, Jaideep; Duseja, Sareen

    2015-01-01

    Objective: The aim of the present case–control study was to evaluate the association between maternal periodontitis and preeclampsia. Association studies between maternal periodontitis and elevated risk for preeclampsia have shown conflicting results. Periodontal maintenance is necessary to reduce the risk of adverse pregnancy outcomes like preeclampsia. Materials and Methods: Periodontal parameters [bleeding on probing, probing depth (PD), and clinical attachment level (CAL)] of 1320 women w...

  8. Role of fetal DNA in preeclampsia (review).

    Science.gov (United States)

    Konečná, Barbora; Vlková, Barbora; Celec, Peter

    2015-02-01

    Preeclampsia is an autoimmune disorder characterized by hypertension. It begins with abnormal cytotrophoblast apoptosis, which leads to inflammation and an increase in the levels of anti-angiogenic factors followed by the disruption of the angiogenic status. Increased levels of fetal DNA and RNA coming from the placenta, one of the most commonly affected organs in pregnancies complicated by preeclampsia, have been found in pregnant women with the condition. However, it remains unknown as to whether this is a cause or a consequence of preeclampsia. Few studies have been carried out on preeclampsia in which an animal model of preeclampsia was induced by an injection of different types of DNA that are mimic fetal DNA and provoke inflammation through Toll-like receptor 9 (TLR9) or cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). The specific mechanisms involved in the development of preeclampsia are not yet fully understood. It is hypothesized that the presence of different fragments of fetal DNA in maternal plasma may cause for the development of preeclampsia. The function of DNase during preeclampsia also remains unresolved. Studies have suggested that its activity is decreased or the DNA is protected against its effects. Further research is required to uncover the pathogenesis of preeclampsia and focus more on the condition of patients with the condition.

  9. Protein profiling of preeclampsia placental tissues.

    Science.gov (United States)

    Shu, Chang; Liu, Zitao; Cui, Lifeng; Wei, Chengguo; Wang, Shuwen; Tang, Jian Jenny; Cui, Miao; Lian, Guodong; Li, Wei; Liu, Xiufen; Xu, Hongmei; Jiang, Jing; Lee, Peng; Zhang, David Y; He, Jin; Ye, Fei

    2014-01-01

    Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated disorder is still not completely understood. The objective of this study is to evaluate the alterations of protein expression and phosphorylations that are important in regulating placental cell function in preterm and term preeclampsia. Using the Protein Pathway Array, 38 proteins in placental tissues were found to be differentially expressed between preterm preeclampsia and gestational age matched control, while 25 proteins were found to be expressed differentially between term preeclampsia and matched controls. Among these proteins, 16 proteins and their associated signaling pathways overlapped between preterm and term preeclampsia, suggesting the common pathogenesis of two subsets of disease. On the other hand, many proteins are uniquely altered in either preterm or term preeclampsia and correlated with severity of clinical symptoms and outcomes, therefore, providing molecular basis for these two subsets of preeclampsia. Furthermore, the expression levels of some of these proteins correlated with neonatal small for gestational age (PAI-1 and PAPP-A) and adverse outcomes (Flt-1) in women with preterm preeclampsia. These proteins could potentially be used as candidate biomarkers for predicting outcomes of preeclampsia.

  10. Serum copeptin and pregnancy outcome in preeclampsia

    Directory of Open Access Journals (Sweden)

    Kehinde Sola Akinlade

    2015-01-01

    Full Text Available Background: A number of biochemical predictors of preeclampsia have been reported, but little is known about their possible relationship with maternal and fetal outcomes. This study determined serum copeptin in pregnant women with preeclampsia and assessed its relationship with pregnancy outcomes. Materials and Methods: Thirty women with severe preeclampsia (SP, 30 with mild preeclampsia (MP, and 30 with uncomplicated pregnancy were enrolled into this study. Serum copeptin, creatinine, and liver function were determined using enzyme-linked immunosorbent assay and colorimetry as appropriate. Pregnancy outcomes, both maternal and fetal, were taken using standard methods. Results: Copeptin was significantly elevated in preeclampsia subjects compared with controls and in SP compared with MP. Assessing the diagnostic property of copeptin for preeclampsia, the area under the curve for copeptin was 0.99. Nine (30% and 3 (10% of SP and MP, respectively had abruptio placenta while 6 (20%, 2 (6.7%, and 1 (3.3% still births were recorded in SP, MP, and controls, respectively. Neonates of mothers with preeclampsia had significantly lower birth weight, infant length, ponderal index, and head circumference compared with neonates of the controls. Copeptin had a significant inverse relationship with birth weight, ponderal index, head circumference, Apgar score, and infant length in neonates of mothers with preeclampsia. Conclusion: Serum copeptin level in the third trimester could predict preeclampsia and its elevation is associated with adverse perinatal outcome.

  11. Oclusión arterial aguda asociada a hidatidosis diseminada

    Directory of Open Access Journals (Sweden)

    Jose Somocurcio

    Full Text Available Hidatidosis o equinococosis son términos usados para denominar a la infestación zoonótica causada por los estadios adulto y larvario (metacéstode del céstode del género Equinococcus (familia tenidae. El término hidatidosis debe ser aplicado a la infestación por el metacéstode mientras que el de equinococosis a los estadios larvario y adulto. En el Perú existe una alta prevalencia de esta infección siendo el hígado y pulmón los órganos más afectados. Existen factores tanto del agente infeccioso como del hospedero que contribuyen a esta infección, donde el componente inmunológico del hospedero es un punto importante tanto en la infección como en la diseminación. En el presente artículo se reporta un caso de oclusión arterial aguda asociada a hidatidosis diseminada en un paciente de 54 años de edad, natural y procedente de Huancavelica, de inicio súbito con un cuadro de obstrucción arterial aguda; que no mejoró luego de la cirugía con fallecimiento a las 48 horas de la presentación

  12. Oclusión arterial aguda asociada a hidatidosis diseminada

    Directory of Open Access Journals (Sweden)

    Jose Somocurcio

    2014-06-01

    Full Text Available Hidatidosis o equinococosis son términos usados para denominar a la infestación zoonótica causada por los estadios adulto y larvario (metacéstode del céstode del género Equinococcus (familia tenidae. El término hidatidosis debe ser aplicado a la infestación por el metacéstode mientras que el de equinococosis a los estadios larvario y adulto. En el Perú existe una alta prevalencia de esta infección siendo el hígado y pulmón los órganos más afectados. Existen factores tanto del agente infeccioso como del hospedero que contribuyen a esta infección, donde el componente inmunológico del hospedero es un punto importante tanto en la infección como en la diseminación. En el presente artículo se reporta un caso de oclusión arterial aguda asociada a hidatidosis diseminada en un paciente de 54 años de edad, natural y procedente de Huancavelica, de inicio súbito con un cuadro de obstrucción arterial aguda; que no mejoró luego de la cirugía con fallecimiento a las 48 horas de la presentación

  13. ÍNDICE ATEROGÉNICO COMO FACTOR DE RIESGO PARA EL SÍNDROME DE PREECLAMPSIA / Atherogenic index as a risk factor for preeclampsia syndrome

    Directory of Open Access Journals (Sweden)

    José P. Rueda Villalpando

    2012-10-01

    Full Text Available ResumenIntroducción y objetivos: La hipertensión inducida por el embarazo o preeclampsia presenta características fisiopatológicas similares a las de la aterosclerosis y las enfermedades cardiovasculares. El propósito del estudio fue identificar los factores de riesgo aterogénico y su relación en la preeclampsia. Método: Se realizó una investigación descriptiva de tipo transversal, con 50 pacientes en el tercer trimestre del embarazo. Mediante la entrevista se establecieron el peso y la talla, para calcular el índice de masa corporal. La tensión arterial > 140/90 mmHg acompañada de edema y proteinuria en el embarazo, se clasificó como hipertensión arterial. Se tomaron muestras de sangre para determinar los valores de colesterol sérico, triglicéridos y HDL. Las variables se expresaron en porcentajes. Resultados: En cada paciente se analizó el número de factores de riesgo y sus asociaciones. Los resultados más relevantes consistieron en que el 76 % presentó sobrepeso u obesidad. En cuanto al síndrome de preeclampsia, se mostró en el 30 % con un riesgo relativo de 3 veces más que las normolipídicas, y 30 % tuvo un índice aterogénico elevado. Conclusiones: La dislipidemia es un factor de riesgo aterogénico de importancia, y en conjunto constituyen un factor de riesgo para la preeclampsia. El incremento del índice aterogénico aumenta la susceptibilidad a la aterogénesis en la preeclampsia. La dislipidemia aparenta ser el punto de inicio de esta cadena de sucesos. El estudio del papel de la dislipidemia podría contribuir a la comprensión de los mecanismos de disfunción endotelial en la preeclampsia. / AbstractIntroduction and Objectives: Pregnancy−induced hypertension or preeclampsia presents pathophysiological features similar to atherosclerosis and cardiovascular disease. Identify atherogenic risk factors and their relationship in preeclampsia was the purpose of this study. Method: We conducted a cross

  14. Increased plasma carnitine concentrations in preeclampsia

    NARCIS (Netherlands)

    Thiele, IGI; Niezen-Koning, KE; van Gennip, AH; Aarnoudse, JG

    2004-01-01

    OBJECTIVE: Preeclampsia is associated with abnormal lipid metabolism, including fatty acid metabolism. Carnitine plays an indispensable role in the oxidation of fatty acids. The aim of the study was to evaluate the possible role of abnormal fatty add oxidation in preeclampsia by comparing plasma car

  15. Pre-eclampsia, eclampsia, and hypertension

    OpenAIRE

    Duley, Lelia

    2011-01-01

    Pre-eclampsia (raised blood pressure and proteinuria) complicates 2% to 8% of pregnancies, and increases morbidity and mortality in the mother and child. Pre-eclampsia is more common in women with multiple pregnancy and in those with conditions associated with microvascular disease.

  16. Preeclampsia: from epidemiological observations to molecular mechanisms

    Directory of Open Access Journals (Sweden)

    P. López-Jaramillo

    2001-10-01

    Full Text Available Preeclampsia is the main cause of maternal mortality and is associated with a five-fold increase in perinatal mortality in developing countries. In spite of this, the etiology of preeclampsia is unknown. The present article analyzes the contradictory results of the use of calcium supplementation in the prevention of preeclampsia, and tries to give an explanation of these results. The proposal of an integrative model to explain the clinical manifestations of preeclampsia is discussed. In this proposal we suggest that preeclampsia is caused by nutritional, environmental and genetic factors that lead to the creation of an imbalance between the free radicals nitric oxide, superoxide and peroxynitrate in the vascular endothelium. The adequate interpretation of this model would allow us to understand that the best way of preventing preeclampsia is the establishment of an adequate prenatal control system involving adequate antioxidant vitamin and mineral supplementation, adequate diagnosis and early treatment of asymptomatic urinary and vaginal infections. The role of infection in the genesis of preeclampsia needs to be studied in depth because it may involve a fundamental change in the prevention and treatment of preeclampsia.

  17. Preeclampsia : At risk for remote cardiovascular disease

    NARCIS (Netherlands)

    Harskamp, Ralf E.; Zeeman, Gerda G.

    2007-01-01

    Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to 3.07

  18. Perinatal epidemiological risk factors for preeclampsia.

    Science.gov (United States)

    Bobić, Mirna Vuković; Habek, Dubravko; Habek, Jasna Čerkez

    2015-03-01

    In the present study, the impact of the potential perinatal epidemiological factors on preeclampsia development was assessed. This clinical study included 55 pregnant women with preeclampsia and control group of 50 healthy pregnant women. Positive family history of cardiovascular disease, diabetes mellitus or thromboembolic disease was recorded in 50% of women with preeclampsia versus 28% of control group women. Positive personal history of this disease was recorded in 15% of women with preeclampsia, whereas all control group women had negative personal history of preeclampsia. Dietary habits, i.e. the intake of meat and meat products, fruit and vegetables, coffee and alcohol drinks were similar in the two groups, without statistically significant differences. The women with preeclampsia and control women reported comparable habits; there was no difference in the consumption of meat, fruit, vegetables, coffee and alcohol, smoking, use of folate and oral hormonal contraception before pregnancy, or in physical activity as the potential risk factors for preeclampsia in current pregnancy. However, personal and family history of vascular disease proved to be significant risk factors for the occurrence of preeclampsia, emphasizing the need of lifestyle and dietary modifications with healthy dietary habits, while avoiding adverse habits in pregnancy.

  19. Hemodynamic studies in preeclampsia: implications for management

    NARCIS (Netherlands)

    W. Visser (Willy)

    1995-01-01

    textabstractPreeclampsia is a condition unique to pregnancy, characterized by hypertension and proteinuria. Nulliparous pregnancies and those affected by preexisting hypertension, diabetes and renal disease are at increased risk. Preeclampsia may develop during pregnancy, labor or in the early puerp

  20. Echocardiographic differences between preeclampsia and peripartum cardiomyopathy.

    Science.gov (United States)

    Dennis, A T; Castro, J M

    2014-08-01

    Peripartum heart failure due to preeclampsia or peripartum cardiomyopathy represents a significant global health issue. Transthoracic echocardiography enables differentiation of heart failure with preserved ejection fraction, commonly observed in women with preeclampsia, from that with peripartum cardiomyopathy in which a reduced ejection fraction is more common. An understanding of the different definitions and diagnostic features of these two diseases, as well as accurate characterisation of the haemodynamics in preeclampsia and peripartum cardiomyopathy, allows clinicians to manage these conditions appropriately. This article outlines the echocardiographic differences between preeclampsia and peripartum cardiomyopathy, the likely mechanisms for heart failure in preeclampsia and the relevance of these differences to clinicians in relation to prevention and treatment. It also emphasises the importance of disease definitions as a key framework for the more consistent classification of the two diseases.

  1. Immunomodulatory role of vitamin D in the pathogenesis of preeclampsia.

    Science.gov (United States)

    Smith, Tyler A; Kirkpatrick, Daniel R; Kovilam, Oormila; Agrawal, Devendra K

    2015-01-01

    Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia has been identified, including endothelial dysfunction, immunological dysregulation and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.

  2. The role of selenium in predicting preeclampsia

    Directory of Open Access Journals (Sweden)

    Z Ghaemi

    2013-10-01

    Full Text Available Introduction: Preeclampsia is a common disorder that is a leading cause of perinatal and maternal morbidity and mortality; however its specific etiology has still remained obscure.The first step in preventing preeclampsia is early detection of women at risk. Since there is no valid and reliable screening test, appropriate diagnostic and screening tests are necessary, which are inexpensive, non-invasive and beneficial for pregnant women. Therefore, regarding the role of selenium as an antioxidant in the prevention preeclampsia, this study was designed which aimed to determine the prognostic value of plasma selenium levels in the diagnosis of preeclampsia in primigravida women Methods: In a nested case control design, a sample of 650 normal primigravida women of 24-28 weeks participated in the study. Subjects who involved the case group were followed up for 3 months and 38 were affected by preeclampsia. Blood samples were obtained from these 38patients as well as from 38 subjects as their matched controls. Moreover, the amount of selenium was measured by atomic absorption spectrometry. Results: The mean level of selenium in blood plasma of the cases was significantly lower than in their matched controls. The present study findings revealed that pregnant women with serum Se < 66.1 μg/L had a significantly increased risk of preeclampsia. Conclusion: Lower plasma selenium level in women destines to suffering from preeclampsia which confirms the destructive effect of selenium deficiency as an antioxidant in etiopathology of preeclampsia. Measurement of plasma selenium can improve the prediction of preeclampsia; thus, it seems that plasma selenium level test owns an acceptable sensitivity and specificity for predicting preeclampsia.

  3. Pesando riscos e benefícios: lições aprendidas com as intervenções terapêuticas de um caso com pré-eclâmpsia grave Balance entre beneficios y riesgos: lecciones aprendidas con las intervenciones terapéuticas de un caso con preclampsia grave Balancing the benefits and risks: lessons learned from the therapeutic interventions of a case with severe preeclampsia

    Directory of Open Access Journals (Sweden)

    Shiqin Xu

    2013-06-01

    érias.JUSTIFICATIVA Y OBJETIVOS: La preclampsia es un síndrome de la disfunción de múltiples órganos (SDMO debido a sus manifestaciones típicas y atípicas que incluyen hipertensión, proteinuria, síndrome HELLP, encefalopatía hipertensiva y coagulopatía. El manejo ideal de esos pacientes necesita una evaluación del balance entre los beneficios y riesgos de las estrategias terapéuticas, anestésicas y obstétricas. RELATO DE CASO: Paciente embarazada de 35 años, con un embarazo anterior sin complicaciones, llegó a nuestro instituto médico en carácter de urgencia a las 29 semanas de embarazo. La paciente estaba con mareos, molestias en el pecho, cardiopalmia, visión nublada y sangramiento vaginal. Posteriormente al examen físico y laboratorial, la paciente fue diagnosticada con preclampsia grave, síndrome HELLP, desplazamiento prematuro de la placenta y SDMO. La paciente también presentaba una deformidad de la columna vertebral y pélvica, fijación de la articulación mandibular y desplazamiento traqueal debido a un accidente de tránsito ocurrido hacía 11 años. Por tanto, se realizó una cesárea de urgencia con anestesia general con intubación nasotraqueal usando un cable guía. La paciente recibió alta directamente de la unidad de cuidados intensivos obstétrica (UCI-OB al séptimo día del postoperatorio, con una presión arterial normal y la recuperación completa de las funciones orgánicas. CONCLUSIONES: Este caso merece una discusión más detallada sobre las consideraciones anestésicas al momento de tomar una decisión clínica para el tratamiento de tal paciente. El bloqueo del neuro eje es la primera elección para pacientes con preclampsia sometidas a la cesárea cuando existe una trombocitopenia moderada, pero no progresiva. Cuando se opta por la anestesia general, una sedación y una analgesia adecuadas se hacen necesarias para el buen control de la respuesta del estrés a la intubación, especialmente en los pacientes con signos neurológicos, y

  4. Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity.

    Science.gov (United States)

    Redman, Christopher W G; Staff, Anne Cathrine

    2015-10-01

    The maternal syndrome of preeclampsia is mediated by dysfunctional syncytiotrophoblast (STB). When this is stressed by uteroplacental malperfusion, its signaling to the mother changes, as part of a highly coordinated stress response. The STB signals are both proinflammatory and dysangiogenic such that the preeclamptic mother has a stronger vascular inflammatory response than normal, with an antiangiogenic bias. Angiogenic factors have limitations as preeclampsia biomarkers, especially for prediction and diagnosis of preeclampsia at term. However, if they are recognized as markers of STB stress, their physiological changes at term demonstrate that STB stress develops in all pregnancies. The biomarkers reveal that the duration of pregnancies is restricted by placental capacity, such that there is increasing placental dysfunction, at and beyond term. This capacity includes limitations imposed by the size of the uterus, the capacity of the uteroplacental circulation and, possibly, the supply of villous progenitor trophoblast cells. Limited placental capacity explains the increasing risks of postmaturity, including preeclampsia. Early-onset preeclampsia is predictable because STB stress and changes in its biomarkers are intrinsic to poor placentation, an early pregnancy pathology. Prediction of preeclampsia at term is not good because there is no early STB pathology. Moreover, biomarkers cannot accurately diagnose term preeclampsia against a background of universal STB dysfunction, which may or may not be clinically revealed before spontaneous or induced delivery. In this sense, postterm pregnancy is, at best, a pseudonormal state. However, the markers may prove useful in screening for women with more severe problems of postmaturity.

  5. Animal models of preeclampsia; uses and limitations.

    LENUS (Irish Health Repository)

    McCarthy, F P

    2012-01-31

    Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality and has an unknown etiology. The limited progress made regarding new treatments to reduce the incidence and severity of preeclampsia has been attributed to the difficulties faced in the development of suitable animal models for the mechanistic research of this disease. In addition, animal models need hypotheses on which to be based and the slow development of testable hypotheses has also contributed to this poor progress. The past decade has seen significant advances in our understanding of preeclampsia and the development of viable reproducible animal models has contributed significantly to these advances. Although many of these models have features of preeclampsia, they are still poor overall models of the human disease and limited due to lack of reproducibility and because they do not include the complete spectrum of pathophysiological changes associated with preeclampsia. This review aims to provide a succinct and comprehensive assessment of current animal models of preeclampsia, their uses and limitations with particular attention paid to the best validated and most comprehensive models, in addition to those models which have been utilized to investigate potential therapeutic interventions for the treatment or prevention of preeclampsia.

  6. How Many Women Are Affected by or at Risk of Preeclampsia?

    Science.gov (United States)

    ... women are affected by or at risk of preeclampsia? Skip sharing on social media links Share this: ... severe preeclampsia or eclampsia. 3 Risk Factors for Preeclampsia Preeclampsia occurs primarily in first pregnancies. Other factors ...

  7. Neumonía intersticial linfoidea asociada a inmunodeficiencia común variable

    Directory of Open Access Journals (Sweden)

    Gonzalo Peralta

    2011-10-01

    Full Text Available La neumonía intersticial linfoidea (NIL es una rara entidad, descripta como hiperplasia no neoplásica del tejido linfoide pulmonar y clasificada dentro de las enfermedades intersticiales idiopáticas. Se la ha descripto asociada a infección por HIV, fenómenos autoinmunes, hipergamaglobulinemia policlonal o menos frecuentemente a hipogammaglobulinemia. Presentamos una paciente de 66 años de edad con diabetes mellitus, síndrome de Sjögren e hipertensión arterial, derivada a nuestro centro por tos seca y disnea clase funcional II-III. En el examen físico presentaba rales tipo “velcro” bibasales y esplenomegalia. Los estudios de laboratorio evidenciaron plaquetopenia (50 000/mm³ e hipogammaglobulinemia; la tomografía axial computarizada (TAC de tórax mostró compromiso intersticial bibasal, con nódulos peribroncovasculares menores a un centímetro. Se realizó una videotoracoscopia con biopsia pulmonar, la anatomía patológica mostró hallazgos compatibles con neumonía intersticial linfoidea. Se inició tratamiento con metilprednisona 40 mg/día vía oral e infusión endovenosa de gammaglobulina 500 mg/kg, mensual, evolucionando con mejoría clínico-radiológica. Por persistencia de plaquetopenia, asociada a hiperesplenismo, se realizó esplenectomía con buena respuesta. En la anatomía patológica no se observo clonalidad linfoide.

  8. Colitis fulminante asociada a Clostridium difficile

    OpenAIRE

    BANNURA C,GUILLERMO; ROSS R,GONZALO; GABLER N,FERNANDO; ESPERGUEL G,CARLOS

    2012-01-01

    Se presenta el caso de una paciente de 46 años sometida a una artroplastía de cadera bilateral que presenta diarrea secundaria a infección por Clostridium difficile (CD), que fi1e tratada con metronidazol y vancomicina por 10 días con buena evolución. Reingresa 3 días después con un cuadro caracterizado por fiebre, compromiso del estado general, diarrea, distensión abdominal, deshidratación y signos de hipotensión. La tomografía computada (TC) mostró imágenes compatibles con colitis pseudomem...

  9. Avaliação do tratamento da discopatia degenerativa cervical pela artrodese via anterior utilizando placas associadas a cages ou cages em peek isoladamente Evaluación del tratamiento de la enfermedad degenerativa del disco cervical por la artrodesis anterior utilizando placas asociadas con jaulas o jaulas en peec, aisladamente Evaluation of cervical degenerative disc disease treatment by anterior arthrodesis using plates associated with cages or cages in peek alone

    Directory of Open Access Journals (Sweden)

    André Rafael Hübner

    2011-01-01

    Full Text Available OBJETIVOS: Avaliar comparativamente o tratamento da discopatia degenerativa cervical por discectomia e artrodese cervical via anterior utilizando placas associadas a cages ou cages em PEEK isoladamente. MÉTODOS: Foi realizado um estudo retrospectivo comparativo entre dois grupos de pacientes operados pela técnica de discectomia e artrodese cervical via anterior. Foram selecionados aleatoriamente 70 pacientes, 35 operados com o método de fixação com placas associadas a cages - denominado Grupo I - e 35 com o cage em PEEK isoladamente - Grupo II. Realizou-se anamnese, exame físico, escores de dor (escala visual e analógica da dor e função (critérios de Odom's, SF-36, Indice de incapacidade do pescoço o pré e pós-operatório e exames de imagem. RESULTADOS: Houve predominância de pacientes do sexo feminino em ambos os grupos, com média de idade de 55 anos no Grupo I e 47 no Grupo II. Ambos os grupos apresentaram distribuição semelhante quanto ao número de níveis operados, assim como nas complicações encontradas e escores de dor, cervicalgia e SF36 no pré e pós-operatório. Houve 97.1% de fusão com 94.3% de bons resultados no Grupo I e 100% de fusão, com 97 % de bons resultados no Grupo II. CONCLUSÕES: O estudo comparativo da utilização de placas com cages e cages em PEEK isoladamente apresentou resultados semelhantes e satisfatórios para os grupos estudados, não se constatando superioridade ou inferioridade de um método com relação ao outro.OBJETIVOS: Evaluar comparativamente el tratamiento de la enfermedad degenerativa del disco cervical por discectomía y artrodesis cervical vía anterior, utilizando placas asociadas con el uso de jaulas o estas en PEEK [Poliéster-Éter-Éter-Cetona], aisladamente. MÉTODOS: fue realizado un estudio retrospectivo comparativo de dos grupos de pacientes tratados con la técnica de discectomía y artrodesis cervical vía anterior. Se seleccionaron al azar 70 pacientes, 35 operados

  10. Pacientes vivendo com HIV/AIDS e coinfecção tuberculose: dificuldades associadas à adesão ou ao abandono do tratamento Pacientes que viven con el VIH/ SIDA y coinfectados con tuberculosis: las dificultades asociadas con la adhesión o abandono del tratamiento Patients living with HIV/AIDS and co-infection by tuberculosis: difficulties associated with treatment compliance or dropout

    Directory of Open Access Journals (Sweden)

    Manoel Pereira de Sousa Filho

    2012-06-01

    Full Text Available Pesquisa realizada em Fortaleza-CE, entre março e abril de 2011, com o objetivo de identificar as dificuldades que influenciam a adesão ou o abandono do tratamento de tuberculose em pacientes com Síndrome da Imunodeficiência Adquirida. Estudo qualitativo, com informações coletadas por meio de entrevista semiestruturada aplicada a pacientes com Síndrome da Imunodeficiência Adquirida e coinfecção tuberculose. Utilizamos o discurso do sujeito coletivo para a análise dos resultados. Os pacientes relataram dificuldades relacionadas aos aspectos socioeconômicos, ao estilo de vida e ao uso da medicação. O uso de álcool e o consumo de drogas ilícitas surgiram como fatores que levam a episódios de interrupção do processo terapêutico da doença. Concluímos que as barreiras relacionadas aos aspectos sociais, econômicos e ao estilo de vida são mais difíceis de serem enfrentadas para uma adesão continuada ao tratamento, tornando necessário o papel desempenhado pelos profissionais da saúde, apoiado por políticas públicas e sociais mais resolutivas.Investigación realizada en Fortaleza-CE, entre marzo y abril de 2011, con el objetivo de describir las dificultades que influyen en la adhesión o abandono del tratamiento de la tuberculosis en pacientes infectados con Virus de la Inmunodeficiencia Humana. Estudio cualitativo, con informaciones recopiladas a través de entrevista semiestructurada, aplicada en pacientes con Síndrome de Inmunodeficiencia Adquirida coinfectados con tuberculosis. Se utilizó el Discurso del Sujeto Colectivo para el análisis de los resultados. Los pacientes relataron dificultades cuanto a los aspectos socioeconómicos, estilo de vida y uso de medicamentos. El uso de alcohol y consumo de drogas fueron factores que llevaron a episodios de interrupción del proceso terapéutico de la enfermedad. Concluimos que obstáculos relacionados a los aspectos sociales, económicos y estilo de vida son más dif

  11. Complicaciones médicas asociadas al abuso de alcohol y drogas

    OpenAIRE

    Rivas Puy, Inmaculada

    2014-01-01

    La adicción al alcohol y las drogas es una enfermedad crónica relacionada con un amplio espectro de complicaciones clínicas asociadas. En la presente Tesis Doctoral mostramos tres aspectos concretos enmarcados en la diversidad de dichas complicaciones. El primero de ellos hace referencia a una enfermedad infecciosa frecuente entre los consumidores de drogas como es la tuberculosis. Las técnicas de detección de interferón gamma (IFN-γ) han demostrado su utilidad en el diagnóstico de infección ...

  12. Enfermedad gingival asociada al paciente pediátrico asmático

    OpenAIRE

    Carfi Marin, Indhira Del Valle; Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima,; Alarcón Palacios, Marco; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    El asma es una enfermedad infl amatoria crónica del sistema respiratorio, caracterizada por ser hipersensible y episódica, reversible y con síntomas de abstracción del fl ujo de aire. La prevalencia del asma ha ido en aumento a través de todas las edades, sexo y grupos raciales; y resulta ser mayor entre los niños que en adultos. Últimamente ha sido asociada en numerosas investigaciones a la prevalencia de caries y enfermedad periodontal, donde diversos factores y la respuesta inmune actúan d...

  13. Respuesta neuroinmunológica en la encefalitis asociada al virus del dengue

    OpenAIRE

    Bárbara Padilla-Docal; Daisy Wainshtok-Tomáss; José Pedro Martínez-Larrarte; Edmundo Rivero-Arias; Ana Herrera- Wainshtok; Jesús Callol-Barroso; Alberto Juan Dorta-Contreras

    2013-01-01

    El virus del dengue es un virus ARN miembro de la familia Flaviviridae, la cual incluye, además, el de la fiebre amarilla, el del Nilo del Oeste y la encefalitis japonesa. Se realizó un estudio retrospectivo con tres pacientes diagnosticados de encefalitis asociada al dengue, en cuyas muestras de suero y líquido cefalorraquídeo se cuantificaron los niveles de las clases mayores de inmunoglobulinas por inmunodifusión radial y la manosa de unión a lectina, proteína de la vía de las lectinas del...

  14. Consumo energético y emisiones asociadas del sector residencial

    OpenAIRE

    Hernández Sánchez, Juan Manuel

    2012-01-01

    El objetivo del artículo es reunir información acerca del consumo energético del sector residencial y sus emisiones asociadas a nivel regional, estatal y europeo. La finalidad es poder contrastar los datos entre sí y comprobar que se ajustan cotejando los resultados con estudios y artículos académicos. En primer lugar se presentan los resultados de consumo y emisiones totales del sector residencial para tres regiones: Cataluña, España y Europa. Para cada una de estas regiones se calcula el...

  15. Preeclampsia As Modulator of Offspring Health

    NARCIS (Netherlands)

    Stojanovska, Violeta; Scherjon, Sicco A; Plösch, Torsten

    2016-01-01

    A balanced intrauterine homeostasis during pregnancy is crucial for optimal growth and development of the fetus. The intrauterine environment is extremely vulnerable to multisystem pregnancy disorders such as preeclampsia, which can be triggered by various pathophysiological factors, such as angioge

  16. Cerebral Autoregulation in Normal Pregnancy and Preeclampsia

    NARCIS (Netherlands)

    van Veen, Teelkien R.; Panerai, Ronney B.; Haeri, Sina; Griffioen, Annemiek C.; Zeeman, Gerda; Belfort, Michael A.

    2013-01-01

    OBJECTIVE: To test the hypothesis that preeclampsia is associated with impaired dynamic cerebral autoregulation. METHODS: In a prospective cohort analysis, cerebral blood flow velocity of the middle cerebral artery (determined by transcranial Doppler), blood pressure (determined by noninvasive arter

  17. Update in the Management of Patients with Preeclampsia.

    Science.gov (United States)

    Dhariwal, Nerlyne K; Lynde, Grant C

    2017-03-01

    Hypertensive disorders of pregnancy complicate approximately 10% of all deliveries in the United States and are a leading cause of maternal and fetal morbidity and mortality. Preeclampsia is defined as hypertension in association with proteinuria, thrombocytopenia, impaired liver function, renal insufficiency, pulmonary edema, or new-onset cerebral or visual disturbances. The greatest risk factor for the development of preeclampsia is a history of preeclampsia. There currently is no effective means for the prevention of preeclampsia. Approximately 39% of patients diagnosed with preeclampsia have hypertension and approximately 20% have proteinuria 3 months postpartum. Preeclampsia increases the risk of patients developing hypertension later in life.

  18. Trophoblast differentiation, fetal growth restriction and preeclampsia.

    Science.gov (United States)

    Huppertz, Berthold

    2011-01-01

    The number of hypotheses trying to decipher the etiologies of preeclampsia and fetal growth restriction (FGR) is still increasing. However, for preeclampsia the actual knowledge we have is that the placenta is a prerequisite for the development of the syndrome. The recent years have seen a shift in understanding of the causes of preeclampsia from mostly focusing on the extravillous trophoblast towards the dysregulation of villous trophoblast development and maintenance. It seems as if a failure of the villous syncytiotrophoblast differentiation results in abnormal release of non-apoptotic fragments into maternal blood. In preeclampsia such necrotic or aponecrotic fragments can be found in maternal blood systemically and seem to be causative in the development of the inflammatory response of the mother. In cases with fetal growth restriction (FGR) extravillous trophoblast fails to adequately transform uterine spiral arteries. However, in FGR cases abnormal development of villous cytotrophoblast may have an impact on fetal nutrition without the induction of an inflammatory response of the mother. It is still unclear why the villous trophoblast fails to achieve an adequate turnover both in preeclampsia and in FGR. However, the detection of new biomarkers for preeclampsia such as placental protein 13 (PP13) has helped in clarifying the issue of when the syndrome starts to develop. PP13 levels in maternal serum are significantly altered already at six to seven weeks of gestation in women subsequently developing preeclampsia. Thus, there needs to be a very early alteration of villous development in such placentas. Herein the changes in villous trophoblast in preeclampsia and FGR are compared and differences between both scenarios are presented.

  19. DNA Methylation as a Biomarker for Preeclampsia

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Cindy M.; Ralph, Jody L.; Wright, Michelle L.; Linggi, Bryan E.; Ohm, Joyce E.

    2014-10-01

    Background: Preeclampsia contributes significantly to pregnancy-associated morbidity and mortality as well as future risk of cardiovascular disease in mother and offspring, and preeclampsia in offspring. The lack of reliable methods for early detection limits the opportunities for prevention, diagnosis, and timely treatment. Purpose: The purpose of this study was to explore distinct DNA methylation patterns associated with preeclampsia in both maternal cells and fetal-derived tissue that represent potential biomarkers to predict future preeclampsia and inheritance in children. Method: A convenience sample of nulliparous women (N = 55) in the first trimester of pregnancy was recruited for this prospective study. Genome-wide DNA methylation was quantified in first-trimester maternal peripheral white blood cells and placental chorionic tissue from normotensive women and those with preeclampsia (n = 6/group). Results: Late-onset preeclampsia developed in 12.7% of women. Significant differences in DNA methylation were identified in 207 individual linked cytosine and guanine (CpG) sites in maternal white blood cells collected in the first trimester (132 sites with gain and 75 sites with loss of methylation), which were common to approximately 75% of the differentially methylated CpG sites identified in chorionic tissue of fetal origin. Conclusion: This study is the first to identify maternal epigenetic targets and common targets in fetal-derived tissue that represent putative biomarkers for early detection and heritable risk of preeclampsia. Findings may pave the way for diagnosis of preeclampsia prior to its clinical presentation and acute damaging effects, and the potential for prevention of the detrimental long-term sequelae.

  20. [The role of angiogenic factors in preeclampsia].

    Science.gov (United States)

    Alasztics, Bálint; Gullai, Nóra; Molvarec, Attila; Rigó, János

    2014-11-23

    Preeclampsia is one of the most common and most serious complications of pregnancy and the management of this condition still challenges obstetricians. Despite intensive research the etiology of preeclampsia still remains unclear. At the beginning of the 2000s preeclampsia-related research was directed towards factors that influence angiogenesis. Most studies have been carried out on the placental growth factor and soluble fms-like tyrosine kinase-1. Most publications confirm the increased concentrations of antiangiogenic factors and decreased concentrations of proangiogenic factors in maternal blood samples in preeclampsia even before the onset of clinical symptoms. According to our current knowledge antiangiogenic proteins are responsible for the endothelial dysfunction in the symptomatic stage of the disease. Placental growth factor and soluble fms-like tyrosine kinase-1 may have important roles in the prediction and treatment of the disease. The point of care detection of placental growth factor and soluble fms-like tyrosine kinase-1 may be used to predict preeclampsia. Rapid tests are available to determine the serum levels of the two proteins. Removal of soluble fms-like tyrosine kinase-1 from maternal circulation is a potential treatment option for early onset preeclampsia.

  1. Prostaglandins, renin, aldosterone, and catecholamines in preeclampsia.

    Science.gov (United States)

    Pedersen, E B; Christensen, N J; Christensen, P; Johannesen, P; Kornerup, H J; Kristensen, S; Lauritsen, J G; Leyssac, P P; Rasmussen, A B; Wohlert, M

    1983-01-01

    Urinary excretion of prostaglandin E2 (PGE2) and F2 alpha (PGF2 alpha), plasma concentrations of renin (PRC), aldosterone (PAC), noradrenaline (PNA) and adrenaline (PA) were determined in the third trimester of pregnancy, 5 days and 3 months after delivery in preeclampsia and normotensive pregnant and non-pregnant control subjects. PGE2 was higher in pregnant control subjects than in non-pregnant subjects, but reduced to non-pregnant level in preeclampsia. PGF2 alpha was the same in preeclampsia and normotensive pregnancy but higher than in the non-pregnant group. PRC and PAC were increased during pregnancy, but considerably lesser in preeclampsia than during normotensive pregnancy. PNA and PA were the same in all three groups. All parameters were normal 3 months after delivery. There were no correlations between any of the hormones and blood pressure in any of the groups. PGE2 was positively correlated to PRC. The lack of renal PGE2 in preeclampsia might be responsible for the decrease in renal blood flow and sodium excretion, and the changes in PRC and PAC are supposed to be secondary to changes in PGE2. It is hypothesised that preeclampsia is a state of prostaglandin deficiency.

  2. Hemostasis in pre-eclampsia.

    LENUS (Irish Health Repository)

    Ismail, Siti Khadijah

    2012-01-31

    Pre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.

  3. Hemostasis in pre-eclampsia.

    LENUS (Irish Health Repository)

    Ismail, Siti Khadijah

    2011-03-01

    Pre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.

  4. The association between nursing diagnoses and the occurrence of falls observed among eldery individuals assisted in an outpatient facility Variables asociadas con la ocurrencia de caidas a partir del diagnósticos de enfermería en ancianos atendidos ambulatorialmente Variáveis associadas à ocorrência de quedas a partir dos diagnósticos de enfermagem em idosos atendidos ambulatorialmente

    Directory of Open Access Journals (Sweden)

    Marcia Duarte Moreira

    2007-04-01

    Full Text Available This is an exploratory descriptive study with a quantitative approach, in which variables associated to the occurrence of falls observed in elderly assisted in an outpatient clinic are delineated from the nursing diagnoses. Data from the files of 490 elderly with age between 60 and 98 years old were investigated. Univariate and bivariate statistical analyses were performed (p Estudio descriptivo - exploratorio con enfoque cuantitativo, en el cual son mencionadas variables asociadas con caídas de ancianos atendidos ambulatoriamente, en base a los diagnósticos de Enfermería. Fueron investigados los registros de informaciones de las historias clínicas de 490 personas ancianas a partir de 60 años. Fue utilizado el análisis estadístico univariado y bivariado (p Trata-se de estudo descritivo exploratório com abordagem quantitativa, no qual são delineadas variáveis associadas à ocorrência de quedas nos idosos atendidos ambulatorialmente, a partir dos diagnósticos de enfermagem. Foram investigados os registros de dados dos prontuários de 490 idosos a partir de 60 anos. As variáveis sofreram análise univariada e bivariada (p<0,05. A variável dependente - ocorrência de quedas - obteve prevalência de 30% com maior proporção no sexo feminino. Foi encontrada associação positiva e independente com os seguintes diagnósticos de enfermagem: perda de equilíbrio (p<0,001, pressão arterial elevada (p<0,001, fraqueza (p<0,025 e incontinência urinária (p<0,025. Não se observou associação entre quedas e os diagnósticos: visão alterada, audição alterada, dores osteoarticulares, marcha alterada e hipotensão postural. O estudo demonstra a importância de se trabalhar melhor as questões relativas às variáveis que apresentaram associação positiva com a ocorrência de quedas, na abordagem de enfermagem.

  5. Cuando la preeclampsia irrumpe inesperadamente en el embarazo: Dolor, miedo y fe en Dios When preeclampsia bursts into pregnancy: Pain, fear, and faith in God

    Directory of Open Access Journals (Sweden)

    Celmira Laza Vásquez

    2012-12-01

    Full Text Available La preeclampsia es la alteración de mayor frecuencia durante la gestación y el puerperio, ocasionando una alta morbilidad en el binomio madre-hijo. Sin embargo, las consecuencias de ésta no deben valorarse solo teniendo en cuenta las alteraciones en la salud que ocasiona en la mujer y su hijo, sino también en términos de lo difícil y doloroso que puede ser la vivencia para las gestantes que han tenido que enfrentarse a esta enfermedad. Este es el relato biográfico de una joven estudiante de enfermería que describe su experiencia de enfrentarse a la preeclampsia durante su primera gestación, cuando ésta irrumpió inesperadamente en su anhelada maternidad, generando miedo y angustia por la gravedad que para ella significó la enfermedad y la posibilidad de la muerte de su hija junto con la experiencia de una larga hospitalización. La fe en Dios y la presencia de su compañero se constituyeron en soporte para sobrellevar los amargos momentos vividos.Preeclampsia is the most frequent disease during pregnancy and delivery, causing high morbidity to the maternofetal unit. However, the difficult, painful life experiences of pregnant women who suffered preeclampsia must be kept in mind, beyond their health alterations. This paper offers the biographical account of a young nursery student, who describes her experience while engaging preeclampsia in her first pregnancy, when disease abruptly stopped her much desired maternity, causing to her fear, distress, and a long hospitalization. God and his mate were her support while leaving behind her bitter experience.

  6. Persistent Maternal Cardiac Dysfunction After Preeclampsia Identifies Patients at Risk for Recurrent Preeclampsia.

    Science.gov (United States)

    Valensise, Herbert; Lo Presti, Damiano; Gagliardi, Giulia; Tiralongo, Grazia Maria; Pisani, Ilaria; Novelli, Gian Paolo; Vasapollo, Barbara

    2016-04-01

    The purpose of our study was to assess cardiac function in nonpregnant women with previous early preeclampsia before a second pregnancy to highlight the cardiovascular pattern, which may take a risk for recurrent preeclampsia. Seventy-five normotensive patients with previous preeclampsia and 147 controls with a previous uneventful pregnancy were enrolled in a case-control study and submitted to echocardiographic examination in the nonpregnant state 12 to 18 months after the first delivery. All patients included in the study had pregnancy within 24 months from the echocardiographic examination and were followed until term. Twenty-two (29%) of the 75 patients developed recurrent preeclampsia. In the nonpregnant state, patients with recurrent preeclampsia compared with controls and nonrecurrent preeclampsia had lower stroke volume (63 ± 14 mL versus 73 ± 12 mL and 70 ± 11 mL, Ppreeclampsia compared with controls (30.0 ± 6.3 g/m(2.7) and 30.4 ± 6.8 g/m(2.7) versus 24.8 ± 5.0 g/m(2.7), Ppreeclampsia. Previous preeclamptic patients with nonrecurrent preeclampsia show left ventricular structural and functional features intermediate with respect to controls and recurrent preeclampsia.

  7. Vascular associated gene variants in patients with preeclampsia

    DEFF Research Database (Denmark)

    Lykke, Jacob A; Bare, Lance A; Olsen, Jørn

    2012-01-01

    Preeclampsia has been linked to subsequent vascular disease with many shared predisposing factors. We investigated the association between severe preeclampsia, and its subtypes, and specific vascular-related polymorphisms....

  8. Preeclampsia and Stroke: Risks during and after Pregnancy

    OpenAIRE

    2011-01-01

    Preeclampsia and stroke are significantly related, both pathologically and temporally (across the life span) in women. Cerebrovascular events can complicate preeclampsia, and can also manifest later in life. A history of preeclampsia is associated with long-term risk for hypertension, stroke, and heart disease. Cerebrovascular complications occur in only a small proportion of women with severe preeclampsia, but with high morbidity and mortality. Endothelial dysfunction and impaired cerebral ...

  9. GASTO CARDÍACO MATERNO COMO PREDICTOR DEL SÍNDROME DE PREECLAMPSIA-ECLAMPSIA / Maternal cardiac output as a predictor of preeclampsia-eclampsia syndrome

    Directory of Open Access Journals (Sweden)

    Luis A. Díaz Moreno

    2012-03-01

    Full Text Available Resumen Introducción y objetivos: La hipertensión es la complicación médica más común del embarazo, y puede dejar secuelas permanentes como: alteraciones neurológicas, hepáticas, hematológicas o renales. Cada tres minutos muere una mujer debido a la preeclampsia. Durante el embarazo el gasto cardíaco sufre un incremento de hasta 40 %. Este incremento es secundario al aumento de aproximadamente 30 % del volumen sistólico. El objetivo de la investigación fue predecir la aparición del síndrome de preeclampsia-eclampsia mediante la identificación de alteraciones del gasto cardíaco. Método: Se realizó un estudio observacional, descriptivo, longitudinal y analítico, de cohorte prospectiva, donde se determinó, por ecocardiografía, el gasto cardíaco en 31 embarazadas, entre las semanas 11 y 13,6 de gestación como único valor; y mediante seguimiento prenatal, se observó la aparición o no del síndrome de Preeclampsia-Eclampsia. Resultados: Se logró el seguimiento de 31 embarazadas a las que se le midió el gasto cardíaco, y se encontró una prevalecía de la enfermedad de 12,9 % con un 64,5 % de pacientes correctamente diagnosticados, con una sensibilidad de 75 %, con valor predictivo positivo de 23 %, especificidad de 62 % y valor predictivo negativo de 94%, con un riesgo relativo de 4,1 (intervalo de confianza 95 %, 0,48-35,6. Conclusiones: Es posible establecer la medición de gasto cardíaco como estudio de escrutinio para predecir la aparición del síndrome de Preeclampsia desde el control prenatal, y contribuir así a la disminución de la muerte materna. / Abstract Introduction and Objectives: Hypertension is the most common medical complication of pregnancy, and it can leave permanent sequelae such as neurological, hepatic, hematological or renal disorders. Every three minutes a woman dies due to preeclampsia. During pregnancy, cardiac output suffers an increase of 40%. This increase is secondary to an increase of

  10. Neumonía asociada al cuidado de la salud

    Directory of Open Access Journals (Sweden)

    Adrián Ceccato

    2014-02-01

    Full Text Available La neumonía asociada al cuidado de la salud (NACS es una entidad diferente a la neumonía adquirida en la comunidad y a la neumonía intrahospitalaria. Existen circunstancias de riesgo para su desarrollo, se describen diferentes formas de presentación, gravedad y patógenos; y hay desacuerdo sobre el tratamiento empírico inicial. El objetivo de este estudio fue analizar la etiología, las características clínicas y la evolución de la NACS en un hospital general. Estudio prospectivo observacional con 60 pacientes; 32 con internación previa en los últimos 90 días, 9 en hemodiálisis, 12 residentes en hogares asistenciales y 7 en tratamiento en un hospital de día. El promedio de edad fue de 63 años; los índices de gravedad al ingreso fueron elevados. Las comorbilidades más frecuentes fueron las cardiológicas. El compromiso radiológico abarcó más de un lóbulo en el 42% de los casos y un 18% mostró derrame pleural. Se aisló el germen patógeno en 18 pacientes (30%; Streptococcus pneumoniae fue el más aislado (9 casos. Solo hubo un caso de multirresistencia. La estadía hospitalaria promedio fue de 11 días; 6 pacientes presentaron complicaciones, y la mortalidad fue del 5%. Las complicaciones, aunque no la mortalidad, fueron significativamente mayores en el grupo en diálisis (valor de p: 0.011 y 0.056, respectivamente. Los cuadros fueron graves pero la mortalidad fue baja. La resistencia antibiótica hallada no justifica un cambio en el esquema antibiótico usado habitualmente en las neumonías de la comunidad.

  11. Associations of personal and family preeclampsia history with the risk of early-, intermediate- and late-onset preeclampsia.

    Science.gov (United States)

    Boyd, Heather A; Tahir, Hassaan; Wohlfahrt, Jan; Melbye, Mads

    2013-12-01

    Preeclampsia encompasses multiple conditions of varying severity. We examined the recurrence and familial aggregation of preeclampsia by timing of onset, which is a marker for severity. We ascertained personal and family histories of preeclampsia for women who delivered live singletons in Denmark in 1978-2008 (almost 1.4 million pregnancies). Using log-linear binomial regression, we estimated risk ratios for the associations between personal and family histories of preeclampsia and the risk of early-onset (before 34 weeks of gestation, which is typically the most severe), intermediate-onset (at 34-36 weeks of gestation), and late-onset (after 36 weeks of gestation) preeclampsia. Previous early-, intermediate-, or late-onset preeclampsia increased the risk of recurrent preeclampsia with the same timing of onset 25.2 times (95% confidence interval (CI): 21.8, 29.1), 19.7 times (95% CI: 17.0, 22.8), and 10.3 times (95% CI: 9.85, 10.9), respectively, compared with having no such history. Preeclampsia in a woman's family was associated with a 24%-163% increase in preeclampsia risk, with the strongest associations for early- and intermediate-onset preeclampsia in female relatives. Preeclampsia in the man's family did not affect a woman's risk of early-onset preeclampsia and was only weakly associated with her risks of intermediate- and late-onset preeclampsia. Early-onset preeclampsia appears to have the largest genetic component, whereas environmental factors likely contribute most to late-onset preeclampsia. The role of paternal genes in the etiology of preeclampsia appears to be limited.

  12. Estudio de las preocupaciones asociadas al embarazo en un grupo de embarazadas primigestas chilenas

    Directory of Open Access Journals (Sweden)

    Chamarrita Farkas

    2008-05-01

    Full Text Available Este artículo se centra en la identificación de las preocupaciones y temores que surgen en el período del primer embarazo. Se utiliza una metodología cualitativa, con un diseño transversal, exploratorio y descriptivo. La muestra se compone de 17 embarazadas primigestas de 19 a 40 años y nivel socio-económico medio, que asistieron a dos talleres de “Promoción del primer vínculo” con una frecuencia semanal durante 6 semanas. A partir de las transcripciones de las sesiones, se identificaron y construyeron categorías de respuesta asociadas a temores y preocupaciones de esta etapa. Los resultados se presentan considerando los temores y preocupaciones asociados al embarazo, al parto y a la primera etapa de la maternidad.

  13. Severe hyponatraemia associated with pre-eclampsia.

    Science.gov (United States)

    Anglim, Breffini; Levins, Kirk; Bussmann, Neidin; Imcha, Mendinaro

    2016-08-24

    Pre-eclampsia is a multisystem disorder with incidence rates ranging from 2% to 5%. Hyponatraemia is a rare complication of pre-eclampsia. A 41-year-old, para 0+1 in vitro fertilisation monochorionic diamniotic triplet pregnancy woman presented at 25 weeks with dyspnoea and general malaise. Her antenatal course was complicated by the diagnosis of intrauterine growth restriction in triplet one at 27 weeks of gestation. At 27+3 weeks gestation, she was diagnosed as having pre-eclampsia. Subsequent biochemical analysis demonstrated hyponatraemia with serum sodium falling steadily to 117 mmol/L over the next 19 days. She was admitted to intensive care unit for stabilisation of fulminant pre-eclampsia and severe hyponatraemia at 30+5 weeks of gestation. Hypertonic saline and intravenous labetolol were administered prior to delivery by caesarean section. She recovered well postdelivery with stabilisation of her blood pressure and normalisation of her sodium level to 135 mmol/L. Awareness and frequent monitoring of hyponatraemia should become an integral part of monitoring women with pre-eclampsia.

  14. Antioxidants for Preventing Preeclampsia: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Adriana Magalhaes Ribeiro Salles

    2012-01-01

    Full Text Available Objective. To investigate the efficacy of antioxidants for preventing preeclampsia and other maternal and fetal complications among pregnant women with low, moderate, or high risk of preeclampsia. Methods. We searched MEDLINE, Embase, CENTRAL, mRCT, and other databases, with no language or publication restrictions. Two independent reviewers selected randomized controlled trials that evaluated the use of antioxidants versus placebo and extracted the relevant data. Relative risks (RRs and 95% confidence intervals (95% CIs were calculated. The data were compiled through the random effects model. Main Results. Fifteen studies were included (21,012 women and 21,647 fetuses. No statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia (RR =0.92; 95% CI: 0.82–1.04, severe preeclampsia (RR =1.03; 95% CI: 0.87–1.22, preterm birth (RR =1.03; 95% CI: 0.94–1.14, and small for gestational age <10th centile (RR =0.92; 95% CI: 0.80–1.05. Side effects were numerically more frequent in the antioxidants group compared to placebo, but without significant statistical difference (RR =1.24; 95% CI: 0.85–1.80. Conclusions. The available evidence reviewed does not support the use of antioxidants during pregnancy for the prevention of preeclampsia and other outcomes.

  15. Risk factors and effective management of preeclampsia

    Directory of Open Access Journals (Sweden)

    English FA

    2015-03-01

    Full Text Available Fred A English,1 Louise C Kenny,1 Fergus P McCarthy1,2 1Irish Centre for Fetal and Neonatal Translational Research (INFANT, Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland; 2Women’s Health Academic Centre, King's Health Partners, St Thomas' Hospital, London, UK Abstract: Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%–8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Significant progress has been made in developing tests to predict risk of preeclampsia in pregnancy, but these remain confined to clinical trial settings and center around measuring angiogenic profiles, including placental growth factor or newer tests involving metabolomics. Less progress has been made in developing new treatments and therapeutic targets, and aspirin remains one of the few agents shown to consistently reduce the risk of developing preeclampsia. This review serves to discuss recent advances in risk factor identification, prediction techniques, and management of preeclampsia in antenatal, intrapartum, and postnatal patients. Keywords: pregnancy, treatment, risk reduction, prediction

  16. Critical pathways for the management of preeclampsia and severe preeclampsia in institutionalised health care settings

    Directory of Open Access Journals (Sweden)

    Daftari Ashi

    2003-10-01

    Full Text Available Abstract Background Preeclampsia is a complex disease in which several providers should interact continuously and in a coordinated manner to provide proper health care. However, standardizing criteria to treat patients with preeclampsia is problematical and severe flaws have been observed in the management of the disease. This paper describes a set of critical pathways (CPs designed to provide uniform criteria for clinical decision-making at different levels of care of pregnant patients with preeclampsia or severe preeclampsia. Methods Clinicians and researchers from different countries participated in the construction of the CPs. The CPs were developed using the following steps: a Definition of the conceptual framework; b Identification of potential users: primary care physicians and maternal and child health nurses in ambulatory settings; ob/gyn and intensive care physicians in secondary and tertiary care levels. c Structural development. Results The CPs address the following care processes: 1. Screening for preeclampsia, risk assessment and classification according to the level of risk. 2. Management of preeclampsia at primary care clinics. 3. Evaluation and management of preeclampsia at secondary and tertiary care hospitals: 4. Criteria for clinical decision-making between conservative management and expedited delivery of patients with severe preeclampsia. Conclusion Since preeclampsia continues to be one of the primary causes of maternal deaths and morbidity worldwide, the expected impact of these CPs is the contribution to improving health care quality in both developed and developing countries. The CPs are designed to be applied in a complex health care system, where different physicians and health providers at different levels of care should interact continuously and in a coordinated manner to provide care to all preeclamptic women. Although the CPs were developed using evidence-based criteria, they could require careful evaluation and

  17. Infecciones intrahospitalarias asociadas a dispositivos invasivos en unidades de cuidados intensivos de un hospital nacional de Lima, Perú

    Directory of Open Access Journals (Sweden)

    Omayra Chincha

    2013-12-01

    Full Text Available Con el objetivo de describir la incidencia de infecciones intrahospitalarias asociadas a dispositivos invasivos en unidades de cuidados intensivos (UCI del Hospital Nacional Cayetano Heredia se realizó un estudio observacional retrospectivo utilizando datos de la Oficina de Epidemiología y Salud Ambiental durante los años 2010 al 2012. Se notificó un total de 222 infecciones intrahospitalarias, la UCI de Medicina tuvo la incidencia por 1000 días de uso del dispositivo más alta para neumonía asociada a ventilador mecánico (28,6; infección del torrente sanguíneo asociado a catéter venoso central (11,9, e infección del tracto urinario asociado a catéter (8,1. Los principales agentes infecciosos aislados fueron Pseudomona sp. (32,3% en la UCI de emergencia, Staphylococcus coagulasa negativo(36% en la UCI de medicina y Candida sp (69,2% en la UCI de cirugía. Las tasas de infecciones asociadas a dispositivos invasivos se reportaron altas semejantes a otros hospitales nacionales con limitados recursos e infraestructura

  18. Infecciones intrahospitalarias asociadas a dispositivos invasivos en unidades de cuidados intensivos de un hospital nacional de Lima, Perú

    Directory of Open Access Journals (Sweden)

    Omayra Chincha

    Full Text Available Con el objetivo de describir la incidencia de infecciones intrahospitalarias asociadas a dispositivos invasivos en unidades de cuidados intensivos (UCI del Hospital Nacional Cayetano Heredia se realizó un estudio observacional retrospectivo utilizando datos de la Oficina de Epidemiología y Salud Ambiental durante los años 2010 al 2012. Se notificó un total de 222 infecciones intrahospitalarias, la UCI de Medicina tuvo la incidencia por 1000 días de uso del dispositivo más alta para neumonía asociada a ventilador mecánico (28,6; infección del torrente sanguíneo asociado a catéter venoso central (11,9, e infección del tracto urinario asociado a catéter (8,1. Los principales agentes infecciosos aislados fueron Pseudomona sp. (32,3% en la UCI de emergencia, Staphylococcus coagulasa negativo(36% en la UCI de medicina y Candida sp (69,2% en la UCI de cirugía. Las tasas de infecciones asociadas a dispositivos invasivos se reportaron altas semejantes a otros hospitales nacionales con limitados recursos e infraestructura

  19. First trimester serum markers to predict preeclampsia.

    Science.gov (United States)

    Huppertz, Berthold; Kawaguchi, Rie

    2012-05-01

    A variety of different biomarkers to predict preeclampsia have been identified in the last ten years. Most of these markers have been detected and quantified in maternal blood, and their potency to predict preeclampsia prior to the onset of clinical symptoms has been evaluated. The amount of such markers depends on various conditions, including the source of the marker (fetal/placental and/or maternal), the interaction of this marker with other proteins in maternal blood as well as the stability of the markers during freezing and thawing. Here we describe two of the putative early, first trimester biomarkers, placental protein 13 and placental growth factor. There is still the hope that - even in the absence of any treatment regimen today - such predictive markers will help to speed the development of a cure for preeclampsia.

  20. [Latest developments: management and treatment of preeclampsia].

    Science.gov (United States)

    Winer, N; Tsasaris, V

    2008-02-01

    Preeclampsia is defined as the association of pregnancy-induced hypertension and proteinuria of 300 mg/24h or more after 20 weeks gestation. It complicates 0.5 to 7% of pregnancies. It is a severe complication of pregnancy, which leads to persisting fetal morbidity and mortality. It is also responsible for maternal morbidity as placental abruption, HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and eclampsia. Without treatment, maternal risks are high. Once the disease is confirmed, the treatment consists of ending the pregnancy. Corticosteroids for lung maturity have to be prioritized depending on the term. Antihypertensive drugs are used to limit maternal complications, in particular, in neurological form. Calcium pump inhibitors are increasingly used as a first line choice. Magnesium sulfate, which is probably not used enough in France, needs to be administered with care and strict monitoring. It can be used to prevent a recurrence of eclamptic fits or in the context of early severe preeclampsia with neurological irritability where an eclamptic fit seems imminent. Preventive treatment of preeclampsia consists essentially of low dose aspirin. The efficacy of this treatment is real but moderate. It decreases the risk of recurrence of preeclampsia by 10 to 15%, of prematurity by 8% and of perinatal mortality by 14%. These figures were recently corrected to 10% for the risk of recurrence of preeclampsia: RR=0.95; 90% CI; (0.84-0.97) and prematurity: RR=0.95; 90%CI; (0.83-0.98). It seems that it has no significant effect on intra-uterine growth restriction (IUGR) and perinatal death prevention. For the main outcome of preeclampsia, there was no evidence that women in any of subgroups as preexisting renal disease, preexisting diabetes or hypertension benefited more or less from the use of antiplatelet agents than those in any other subgroup.

  1. Evidence-based management for preeclampsia.

    Science.gov (United States)

    von Dadelszen, Peter; Menzies, Jennifer; Gilgoff, Sarah; Xie, Fang; Douglas, M Joanne; Sawchuck, Diane; Magee, Laura A

    2007-05-01

    This review reflects both the variable presentation and the systemic nature of preeclampsia. Recommendations for the comprehensive evaluation and management of organ dysfunction associated with pre-eclampsia are included. The main points in the review are that: (1) Preeclampsia is a systemic disorder that may affect many organ systems. (2) For preeclampsia remote from term (management improves perinatal outcomes, but requires obsessive surveillance to mitigate maternal risks and is a "package." (3) Initial assessment and ongoing surveillance of women with preeclampsia should include assessment of all vulnerable maternal organs as well as of the fetus. (4) Initiate antihypertensive drug treatment immediately if sBP >160 mmHg or dBP more than 110 mmHg, or if sBP 140-159 mmHg and/or dBP 85-109 mmHg (prepregnancy renal disease or diabetes). (5) The treatment of nonsevere pregnancy hypertension should include a treatment goal of dBP 80-105 mmHg (depending on practitioner preference), with one of the following agents, Methyldopa, Labetalol, Nifedipine, or, with special indications (renal or cardiac diseases), diuretics. (6) Drugs to avoid: angiotensin-converting enzyme inhibitors; angiotensin II receptor antagonists; and atenolol. (7) For the acute management of severe hypertension, initially reduce dBP by 10 mmHg and maintain the blood pressure at or below that level with either Nifedipine or Labetalol. (8) For both prophylaxis against and treatment of eclampsia, MgSO4 (4 g IV stat, then 1 g/hr). (9) For recurrent seizures, MgSO4 (2g IV stat, then increase to 1.5 g/hr). (10) Total fluid intake should not exceed 80 ml/hr; tolerate urine outputs as low as 10 ml/hr. (11) Early-onset and/or severe preeclampsia predict later cardiovascular morbidity and mortality; it would seem prudent to offer such women screening and lipid lowering interventions.

  2. Ethical issues related to screening for Preeclampsia

    DEFF Research Database (Denmark)

    Jørgensen, Jennifer M.; Hedley, Paula L.; Gjerris, Mickey;

    2014-01-01

    The implementation of new methods of treating and preventing disease raises many question of both technical and moral character. Currently, many studies focus on developing a screening test for preeclampsia (PE), a disease complicating 2–8% of pregnancies, potentially causing severe consequences...... feasibility and clinical efficacy, it also requires an analysis of how the test influences the conditions and choices for those tested. This study evaluates state-of-the-art techniques for preeclampsia screening in an ethical framework, pointing out the central areas of moral relevance within the context...

  3. Pre-eclampsia: pathophysiology, diagnosis, and management

    OpenAIRE

    Ayoubi JM

    2011-01-01

    Jennifer Uzan1, Marie Carbonnel1, Olivier Piconne1,3, Roland Asmar2, Jean-Marc Ayoubi11Department of Gynecology and Obstetrics, Hôpital Foch, Suresnes, France; 2Foundation Medical Research Institutes, Geneva, Switzerland; 3Department of Gynecology and Obstetrics, Hôpital Antoine Béclère, Clamart, FranceAbstract: The incidence of pre-eclampsia ranges from 3% to 7% for nulliparas and 1% to 3% for multiparas. Pre-eclampsia is a major cause of maternal mo...

  4. Francisella philomiragia, bacteria asociada con altas mortalidades en salmones del Atlántico (Salmo salar cultivados en balsas-jaulas en el lago Llanquihue Francisella philomiragia, a bacteria associated with high mortalities in Atlantic salmon (Salmo salar cage-farmed in Llanquihue lake

    Directory of Open Access Journals (Sweden)

    H Bohle

    2009-01-01

    Full Text Available Francisella philomiragia fue aislada de salmón del Atlántico cultivado en balsas-jaulas en el lago Llanquihue con brotes de una enfermedad granulomatosa con altas tasas de morbilidad y mortalidad acumuladas entre 5% a 20%. Los aislados bacterianos tienen 100% similitud con F. philomiragia ssp noatunensis o F. piscicida aislado de bacalao en Noruega, 99% de similitud con Francisella sp. detectado en tilapia en Asia y Centroamérica y 99% de similitud con la especie tipo F. philomiragia por análisis filogenético del gen 16s rDNA.Francisella philomiragia was isolated from Atlantic salmon cage-farmed in the Llanquihue lake with outbreaks of a granulomatous disease, with high rates of morbidity and an accumulated mortalities between 5% to 20%. The isolates had 100% similarity with F. philomiragia ssp noatunensis or F. piscicida isolated in Atlantic cod, 99% similarity with Francisella sp. detected in tilapia from Asia and Central America and 99% of similarity with the reference strain F. philomiragia through 16s rDNA phylogenetic analysis.

  5. Ensayo clínico randomizado prospectivo experimental en humanos, del comportamiento de la matriz de colágeno de origen porcino (Mucoderm ®), usada sola o asociada a plasma rico en factores de crecimiento, en comparación con la técnica de injerto gingival libre

    OpenAIRE

    Gioia Palavecino, Claudio Francisco

    2016-01-01

    1. OBJETIVOS El objetivo del presente estudio fue evaluar si el empleo de plasma rico en factores de crecimiento (PRGF) supone una mejoría respecto del empleo de Mucoderm® solo, en pacientes con una cantidad limitada de encía queratinizada. 2. METODOLOGÍA Para el desarrollo del estudio se seleccionaron 21 pacientes con edades comprendidas entre los 18 y los 80 años que presentaban áreas en las cuales la presencia de encía queratinizada era menor de 2 mm., existiendo una afectación ...

  6. Enfermedad pulmonar intersticial asociada a rituximab

    OpenAIRE

    Marcelo Fernández Casares; Gisela Espósito; Alejandra González; Jaime Segovia; María de los Ángeles Galperín; Eduardo Del Valle

    2013-01-01

    La introducción en la práctica clínica del anticuerpo anti-CD20 rituximab ha mejorado sustancialmente el pronóstico de diversas enfermedades autoinmunes y hematológicas. Con el incremento de su uso ha aumentado el registro de efectos adversos, entre ellos la toxicidad pulmonar. Una de sus complicaciones más serias es la enfermedad pulmonar intersticial, entidad potencialmente fatal que debe ser considerada en pacientes que han recibido rituximab y presentan disnea, fiebre y tos sin clara evid...

  7. Cervicobraquialgia asociada a sindrome de Coob

    OpenAIRE

    Luís Rafael Moscote Salazar

    2013-01-01

     Resumen La cervicobraquialgia es el dolor cervical irradiado a una de las extremidades superiores. Es un síndrome clínico que puede estar causado por diversas patologías. El síndrome de Coob consiste en la asociación de una malformación vascular que compromete la piel y malformación vascular de la medula espinal. Presentamos el caso de un paciente con cervicobraquialgia y síndrome de Coob manejado por el Servicio de Neurocirugía del Hospital Universitario CARI en Barranquilla, Colombia. (DUA...

  8. Placenta Copper Transport Proteins in Preeclampsia

    Science.gov (United States)

    Placental insufficiency underlying preeclampsia (PE) is associated with impaired placental angiogenesis. As copper (Cu) is essential to angiogenesis, we investigated differences in the expression of placental Cu transporters Menkes (ATP7A), Wilsons (ATP7B) and the Cu chaperone (CCS) for superoxide d...

  9. Neurologic Complications of Pre-eclampsia

    NARCIS (Netherlands)

    Zeeman, Gerda G.

    2009-01-01

    Pre-eclampsia is mainly responsible for the world's large maternal mortality rates, mostly due to acute cerebral complications. This review provides insight into the pathogenesis of the neurologic complications of hypertensive disease in pregnancy. In addition, practical relevance for clinical care

  10. Hydrogen Sulfide in Preeclampsia : Potential Therapeutic Implications

    NARCIS (Netherlands)

    Holwerda, Kim

    2015-01-01

    The thesis provide insights into the production and possible therapeutic effect of the gaseous molecule hydrogen sulfide (H2S) in preeclampsia (PE). H2S is an important molecule in the (human) body. It is among others involved in blood pressure regulation, stimulation of vascular growth and modulati

  11. Prediction of preeclampsia with angiogenic biomarkers

    DEFF Research Database (Denmark)

    Andersen, Louise Bjørkholt; Dechend, Ralf; Jørgensen, Jan Stener;

    2016-01-01

    OBJECTIVE: We aimed to investigate how maternal serum soluble Fms-like kinase 1 (sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio prospectively associate to preeclampsia (PE) and clinical subtypes. METHODS: In an unselected cohort of 1909 pregnant women, sFlt-1 and PlGF were measured...

  12. Visual Disturbances in (Pre)eclampsia

    NARCIS (Netherlands)

    Roos, Nina M.; Wiegman, Marjon J.; Jansonius, Nomdo M.; Zeeman, Gerda G.

    2012-01-01

    This review aims to summarize existing information concerning visual disturbances in (pre) eclampsia that have been described in the literature. Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality worldwide. Visual disturbances in (pre) eclampsia seem to be freque

  13. Stress responses and pre-eclampsia.

    Science.gov (United States)

    Redman, C W G

    2013-04-01

    Biological stress may affect individual cells, tissues or whole organisms, arising from disturbed homoeostasis of any cause. Stress is rarely localised. Because biological systems are closely integrated, it spreads to involve other systems. Stress responses are highly integrated and work to restore homoeostasis. Different response pathways overlap and interlink. If the responses fail or decompensate, distress ensues, of which the end-stage is death. Pre-eclampsia results from a series of biological stresses, possibly from conception, which become established by abnormal placentation and affect the mother, her foetus and her placenta. The stresses involve dialogue between mother and placenta. Even a normal placenta imposes substantial stress on maternal systems. When placental growth and perfusion is abnormal (poor placentation) then the placenta, particularly its outer trophoblast layer, becomes stressed - loosely denoted hypoxic damage or oxidative stress. Signals from the placenta spread the stress to the mother, who develops signs of pre-eclampsia. Cellular stress sensors initiate stress responses. Different stresses may trigger similar responses in specific cell types. The first cell response is reduced protein synthesis. However some synthetic pathways are spared or activated to produce stress signals. In relation to pre-eclampsia and the placenta, an excessive release of sFlt-1 a soluble decoy receptor for vascular endothelial growth factor (VEGF) is a trophoblast related stress signal. SFlt1 perturbs the angiogenic balance in the maternal circulation and is considered to cause many of the specific features of the maternal syndrome in pre-eclampsia. Three key points will be emphasised. First, multiple stressors, not simply hypoxia, stimulate the release of sFlt-1 from trophoblast. Second, sFlt-1 is only one of the group of stress signals delivered by trophoblast to the mother. Third, sFlt-1 is not the only trophoblast derived factor to perturb the maternal

  14. Pre-eclampsia and childhood asthma.

    Science.gov (United States)

    Magnus, Maria C; Håberg, Siri E; Magnus, Per; Engeland, Anders; Nafstad, Per; Karlstad, Øystein; Nystad, Wenche

    2016-12-01

    Studies of pre-eclampsia and childhood asthma are conflicting, and none have performed a formal mediation analysis of preterm birth.We examined the association between pre-eclampsia and asthma at 7 years using national registries, including all births in Norway from 1999 to 2006 (n=406 907), and a subsample of children in the Norwegian Mother and Child Cohort Study (MoBa) (n=45 028) using log-linear regression. We performed a mediation analysis of preterm birth, and a sibling comparison to evaluate unobserved confounding.There was a positive association between pre-eclampsia and asthma in the registry study, with an adjusted relative risk of 1.31 (95% CI 1.22-1.41), but not in MoBa, which had an adjusted relative risk of 1.19 (95% CI 0.99-1.44). The odds ratios for the direct effect not mediated through preterm birth and the indirect effect in the registry linkage were 1.19 (95% CI 1.10-1.29) and 1.12 (95% CI 1.11-1.14), respectively. The sibling comparison indicated no association between pre-eclampsia and asthma (adjusted OR 1.07, 95% CI 0.87-1.33).In this large study, which used different datasets and analytic approaches, there was little evidence for an association between pre-eclampsia and childhood asthma. The association was weak and largely explained by pre-term birth and confounders shared by siblings.

  15. [Effect of astaxanthin on preeclampsia rat model].

    Science.gov (United States)

    Xuan Rong-rong; Gao Xin; Wu, Wei; Chen, Hai-min

    2014-10-01

    The effect of astaxanthin on N(Ω)-nitro-L-arginine methyl ester (L-NAME) induced preeclampsia disease rats was investigated. Thirty pregnant Sprague-Dawley rats were randomly divided into three groups (n = 10): blank group, L-NAME group and astaxanthin group. From day 5 to 20, astaxanthin group rats were treated with astaxanthin (25 mg x kg(-1) x d(-1) x bw(-1)) from pregnancy (day 5). To establish the preeclamptic rat model, L-NAME group and astaxanthin group rats were injected with L-NAME (125 mg x kg(-1) x d(-1) x bw(-1)) from days 10-20 of pregnancy. The blood pressure and urine protein were recorded. Serum of each group was collected and malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide synthase (NOS) activities were analyzed. Pathological changes were observed with HE stain. The expression of NF-κB (nuclear factor kappa B), ROCK II (Rho-associated protein kinase II), HO-1 (heme oxygenase-1) and Caspase 3 were analyzed with immunohistochemistry. L-NAME induced typical preeclampsia symptoms, such as the increased blood pressure, urinary protein, the content of MDA, etc. Astaxanthin significantly reduced the blood pressure (P astaxanthin, the thickness of basilal membrane was improved and the content of trophoblast cells and spiral arteries was reduced. Immunohistochemistry results revealed that the expressions of NF-κB, ROCK II and Caspase 3 in placenta tissue were effectively decreased, and HO-1 was increased. Results indicated that astaxanthin can improve the preeclampsia symptoms by effectively reducing the oxidative stress and inflammatory damages of preeclampsia. It revealed that astaxanthin may be benefit for prevention and treatment of preeclampsia disease.

  16. Cloning and sequencing genes related to preeclampsia

    Institute of Scientific and Technical Information of China (English)

    SHI Juan-zi; LIU Yan-fang; YAO Yuan-qing; YAN Wei; ZHU Feng; ZHAO Zhong-liang

    2001-01-01

    To clone genes specifically expressed in the placenta of patients with preeclampsia, and to explain the mechanism in the etiopathology ofpreeclampsia. Methods: The placentae ofpreeclamptic and normotensive subjects with pregnancy were used as models, and the cDNA Library was constructed and 20 differentially expressed fragments were cloned after a new version of PCR-based subtractive hybridization. The false positive clones were identified by reverse dot blot analysis. With one of the obtained gene taken as the probe, the placentas of 10 normal pregnant women and 10 preeclamptic patients were studied by using dot hybridization methods. Results: Six false positive clones were identified by reverse dot blot, and the rest 14 clones were identified as preeclampsia-related genes. These clones were sequenced, and analyzed with BLAST analysis system. Eleven of 14 clones were genes already known, among which one belongs to necdin family; the rest 3 were identified as novel genes. These 3 genes were acknowledged by GenBank, with the accession numbers AF232216, AF232217, AF233648. The results of dot hybridization using necdin gene as probe were as follows: (1) There was this mRNA in the placental tissues of normal pregnancy as well as in that ofpreeclampsia.(2) The intensity of transcription of this mRNA in the placental tissues of preeclampsia increased significantly compared with that of the normal pregnancy (P<0.05). Conclusions: This study for the first time reported this group of genes, especially necdin-expressing gene, which are related to the etiopathology of preeclampsia. In addition, the overtranscription ofnecdin gene has been found in preeclampsia. It is helpful in further studies of the etiology ofpreeclampsia.

  17. Low Soluble Syndecan-1 Precedes Preeclampsia.

    Directory of Open Access Journals (Sweden)

    Robin E Gandley

    Full Text Available Syndecan-1 (Sdc1; CD138 is a major transmembrane heparan sulfate proteoglycan expressed on the extracellular, luminal surface of epithelial cells and syncytiotrophoblast, thus comprising a major component of the glycocalyx of these cells. The "soluble" (shed form of Sdc1 has paracrine and autocrine functions and is normally produced in a regulated fashion. We compared plasma soluble Sdc1 concentrations, in relation to placental Sdc1 expression, in uncomplicated (control and preeclamptic pregnancies.We evaluated soluble Sdc1 across uncomplicated pregnancy, and between preeclamptic, gestational hypertensive and control patients at mid-pregnancy (20 weeks and 3rd trimester by ELISA. Placental expression level of Sdc1 was compared between groups in relation to pre-delivery plasma soluble Sdc1. Participants were recruited from Magee-Womens Hospital.In uncomplicated pregnancy, plasma soluble Sdc1 rose significantly in the 1st trimester, and reached an approximate 50-fold increase at term compared to post pregnancy levels. Soluble Sdc1 was lower at mid-pregnancy in women who later developed preeclampsia (P<0.05, but not gestational hypertension, compared to controls, and remained lower at late pregnancy in preeclampsia (P<0.01 compared to controls. Sdc1 was prominently expressed on syncytiotrophoblast of microvilli. Syncytiotrophoblast Sdc1 immunostaining intensities, and mRNA content in villous homogenates, were lower in preeclampsia vs. controls (P<0.05. Soluble Sdc1 and Sdc1 immunostaining scores were inversely associated with systolic blood pressures, and positively correlated with infant birth weight percentile.Soluble Sdc1 is significantly lower before the clinical onset of preeclampsia, with reduced expression of Sdc1 in the delivered placenta, suggesting a role for glycocalyx disturbance in preeclampsia pathophysiology.

  18. Prevalencia de sobrepeso y obesidad materna y sus complicaciones obstétrico-neonatales asociadas, Hospital Vicente Corral Moscoso, 2014

    OpenAIRE

    Cangas Herrera, Víctor Javier

    2016-01-01

    Introducción: La obesidad materna es un factor de riesgo que incrementa la frecuencia de problemas maternos como hipertensión arterial, diabetes, preeclampsia; problemas en el momento del parto como: mayor frecuencia de cesáreas, mayor tiempo quirúrgico; y, del recién nacido: macrosomía, distres respiratorio, entre otros. Metodología: Para el efecto se realizó un estudio observacional, analítico transversal, con una muestra de 823 parturientas. Se estudiaron las variables, riesgo de hemo...

  19. On the pathology of preeclampsia : genetic variants, complement dysregulation and angiogenesis

    NARCIS (Netherlands)

    Buurma, Aletta Atje Jacoba

    2013-01-01

    Preeclampsia is a pregnancy-specific condition that originates in the placenta. Despite decades of research, its pathogenesis remains largely unknown. However, several risk factors for preeclampsia have been identified, including a (family) history of preeclampsia, autoimmune disease and conditions

  20. How Do Health Care Providers Diagnose Preeclampsia, Eclampsia, and HELLP Syndrome?

    Science.gov (United States)

    ... and Publications How do health care providers diagnose preeclampsia, eclampsia, and HELLP syndrome? Skip sharing on social ... weeks of pregnancy. Gestational hypertension can develop into preeclampsia. 1 Mild preeclampsia is diagnosed when a pregnant ...

  1. Protocolo del ensayo clínico: “dopamina comparada con fenilefrina para prevención y manejo de la hipotensión arterial asociada a anestesia subaracnoidea para cesárea segmentaria categoría nice 3-4: un ensayo clínico aleatorizado, ciego, de no inferioridad

    OpenAIRE

    González Maldonado, Julián Felipe

    2014-01-01

    Antecedentes: La anestesia subaracnoidea en cesárea se asocia hasta en un 90% a hipotensión arterial, la cual puede generar morbilidad materna y fetal. Entre las opciones de prevención y manejo están los vasopresores fenilefrina y efedrina. En Colombia se tiene mayor disponibilidad de otros vasopresores como la dopamina, sin embargo la evidencia sobre su efectividad y seguridad no es definitiva. Objetivo: Establecer la no inferioridad de dopamina, comparada con fenilefrina, par...

  2. La preeclampsia y la hipertensión gestacional como factores de riesgo para el desarrollo del estado de prehipertensión y de hipertensión arterial a las doce semanas posparto. Un estudio descriptivo prospectivo

    Directory of Open Access Journals (Sweden)

    Bernardo Agudelo Jaramillo

    2008-11-01

    Full Text Available OBJETIVO: explorar si la preeclampsia y la hipertensión gestacional son factores de riesgo para los estados prehipertensivo e hipertensivo a las doce semanas posparto. DISEÑO: estudio descriptivo prospectivo de pacientes del área metropolitana del valle de Aburrá, hospitalizadas por preeclampsia o hipertensión gestacional, a quienes se les atendió el parto en el Hospital Universitario San Vicente de Paúl de Medellín, Colombia, y se les hizo seguimiento hasta las doce semanas posparto. MÉTODO: se midió la presión arterial a las doce semanas posparto en las pacientes que cumplieron con los criterios de inclusión con el fin de establecer la presencia de estado prehipertensivo o de hipertensión. RESULTADOS: 51 pacientes cumplieron los criterios de inclusión, 28 (55% con preeclampsia y 23 (45% con hipertensión gestacional; 28,6% (8/28 de las mujeres en el grupo con preeclampsia y 26,1% (6/23 en el grupo con hipertensión gestacional estaban prehipertensas a las doce semanas posparto; 28,6% (8/28 de las pacientes en el grupo con preeclampsia y 21,7% (5/23 en el grupo con hipertensión gestacional estaban hipertensas a las doce semanas posparto. CONCLUSIÓN: la preeclampsia y la hipertensión gestacional están relacionadas con la presencia de prehipertensión e hipertensión a las doce semanas posparto.

  3. Respuesta neuroinmunológica en la encefalitis asociada al virus del dengue

    Directory of Open Access Journals (Sweden)

    Bárbara Padilla-Docal

    2013-12-01

    Full Text Available El virus del dengue es un virus ARN miembro de la familia Flaviviridae, la cual incluye, además, el de la fiebre amarilla, el del Nilo del Oeste y la encefalitis japonesa. Se realizó un estudio retrospectivo con tres pacientes diagnosticados de encefalitis asociada al dengue, en cuyas muestras de suero y líquido cefalorraquídeo se cuantificaron los niveles de las clases mayores de inmunoglobulinas por inmunodifusión radial y la manosa de unión a lectina, proteína de la vía de las lectinas del sistema del complemento por fluorometría. En el reibergrama se muestra la presencia de síntesis intratecal de las tres clases de inmunoglobulinas y ausencia de síntesis intratecal de lectina de unión a manosa. Existieron diferencias en cuanto al por ciento de síntesis intratecal de inmunoglobulinas, las cuales estuvieron relacionadas con el momento de la infección por el virus y la aparición de las manifestaciones neurológicas compatibles con una encefalitis. Este es el primer reporte de afectaciones neurológicas en pacientes cubanos con dengue. La respuesta inmune intratecal puede ser utilizada para el mejor conocimiento de la enfermedad y contribuir al desarrollo de posibles candidatos vacunales.

  4. Fitotoxicidad de herbicidas postemergentes sobre Adesmia bicolor (Poir. DC y control de malezas asociadas

    Directory of Open Access Journals (Sweden)

    V.A Autrán

    2013-12-01

    Full Text Available Un mejor conocimiento del manejo de las especies nativas de leguminosas forrajeras como Adesmia bicolor puede ayudar a lograr una mayor calidad y estabilidad en la producción de los pastizales. No existe información disponible en la Argentina sobre el tipo y dosis de herbicidas adecuados para el control de malezas en A. bicolor. Los objetivos fueron evaluar el efecto fitotóxico de herbicidas postemergentes a diferentes dosis sobre A. bicolor y el control de las malezas latifoliadas que crecen asociadas en ensayos a campo durante 2009 y 2010. El diseño fue de parcelas divididas donde la parcela mayor fue el tipo de herbicida (2,4-DB e imazetapir y la parcela menor la dosis (1/4X, 1/2X, 1X, 2X, 4X, 8X, siendo X = 250 g i.a. ha-1 para 2,4-DB y X=100 g i.a. ha-1 para imazetapir, con tres repeticiones para cada tratamiento. La materia seca de A. bicolor y el control de malezas se ajustaron a curvas de dosis-respuesta. Se observó efectos fitotóxicos aun con muy baja dosis de 2,4-DB, mientras que imazetapir mostró baja fitotoxicidad para las dosis entre 25 y 100 g a.i. ha-1. El control de malezas con ambos herbicidas fue mayor al 80% con dosis de 1X.

  5. A baixa estatura leve está associada ao aumento da pressão arterial em adolescentes com sobrepeso La baja estatura leve está asociada al aumento de la presión arterial en adolescentes con sobrepeso Mild stunting is associated with higher blood pressure in overweight adolescents

    Directory of Open Access Journals (Sweden)

    Ana Paula Grotti Clemente

    2012-01-01

    confirmam que a baixa estatura leve aumenta o risco futuro de hipertensão e essas alterações são evidentes em indivíduos jovens.FUNDAMENTO: Estudios han demostrado que la desnutrición pre/post-natal lleva a un mayor riesgo de enfermedades no transmisibles, como diabetes, hipertensión y obesidad en la edad adulta. OBJETIVO: Determinar si los adolescentes con sobrepeso y desnutrición leve [escores-Z altura/edad (HAZ en la franja de -2] tienen presión arterial más elevada que los individuos con sobrepeso y con estatura normal (HAZ > -1. MÉTODOS: Los participantes fueron clasificados como de baja estatura leve o de estatura normal, y estratificados de acuerdo con los percentiles de masa corporal para la edad, como sobrepeso, peso normal o abajo del peso. Las presiones arteriales sistólica (PAS y diastólica (PAD fueron determinadas de acuerdo con las directrices y la grasa abdominal fue analizada por absorciometría de doble emisión de rayos-X. RESULTADOS: Individuos con baja estatura leve y sobrepeso presentaron valores más elevados de la PAD (p = 0,001 que sus contrapartes de bajo peso (69,75 ± 12,03 y 54,46 ± 11,24 mmHg, respectivamente, pero semejantes a aquellos con IMC normal. No fueron encontradas diferencias en los valores de PAD en individuos normales, individuos con sobrepeso y con bajo peso entre los grupos de estatura normal. Fue encontrado un aumento en la PAS (p = 0,01 entre los individuos con baja estatura leve cuando fueron comparados los individuos con sobrepreso con sus contrapartes de bajo peso y IMC normal (114,70 ± 15,46, 97,38 ± 10,87 y 104,72 ± 12,24 mmHg, respectivamente. Aunque no hayan sido observadas diferencias en las medias de PAS entre los grupos de baja estatura leve y estatura normal, fue encontrado un intercepto significativo (p = 0,01, revelando mayor PAS entre los individuos con baja estatura leve. Hubo correlación entre PAS y grasa abdominal (r = 0,42, ρ = 0,02 en el grupo con baja estatura leve. CONCLUSIONES: Individuos

  6. Anestesia peridural contínua com ropivacaína a 0,2% associada a anestesia geral para cirurgia do abdômen superior em crianças Anestesia peridural contínua con ropivacaína a 0,2% asociada a anestesia general para cirugía del abdomen superior en niños Continuous epidural anesthesia with 0.2% ropivacaine associated to general anesthesia for upper abdominal surgery in children

    Directory of Open Access Journals (Sweden)

    Jyrson Guilherme Klamt

    2003-04-01

    pacientes do grupo Sufentanil. CONCLUSÕES: A combinação da anestesia peridural torácica contínua com ropivacaína a 0,2% (1,5 ml.kg-1 associada à infusão de propofol promove anestesia efetiva e segura para cirurgias abdominais altas em crianças. O ritmo de infusão de propofol e o tempo de sedação foram reduzidos com a adição de sufentanil.JUSTIFICATIVA Y OBJETIVOS: Técnicas anestésicas han sido empleadas en pacientes pediátricos para varios tipos de cirugías, presentando entre otras ventajas, la analgesia pós-operatoria. El objetivo de este estudio fue evaluar el ritmo de infusión de propofol y la recuperación pós-anestésica de niños sometidos a cirugía abdominal alta bajo anestesia peridural torácica con ropivacaína a 0,2%, asociada a anestesia general con propofol o propofol más sufentanil. MÉTODO: Veintiséis niños ASA I, II y III, con edades entre 0 y 4 años, sometidos a cirugía abdominal alta fueron seleccionados para anestesia peridural torácica (T7-T8 con ropivacaína a 0,2% (1,5 ml.kg-1. Fueron divididos aleatoriamente en dos grupos: Propofol (infusión de propofol y Sufentanil (infusión de propofol más sufentanil 1 µg.kg-1. Los ritmos de infusiones de propofol fueron de 20 y 10 mg.kg-1.h-1 en los grupos Propofol y Sufentanil, respectivamente, ajustadas de modo a mantener la presión arterial cerca de 20% de los valores pré-inducción e interrumpidas 10 a 15 minutos antes del final estimado de la cirugía. La recuperación pós-anestésica fue evaluada a través de una escala modificada de Aldrete-Kroulik y sedación evaluada a través de una escala de 5 puntos. RESULTADOS: Dos niños de cada grupo fueron excluidos por problemas técnicos. El ritmo de infusión fue significativamente menor en el grupo Sufentanil en relación al grupo Propofol durante 100 minutos después del inicio de la cirugía. Los tiempos para extubación y transferencia para la sala de recuperación pós-anestésica (SRPA fueron significativamente menores en

  7. Cervicobraquialgia asociada a sindrome de Coob

    Directory of Open Access Journals (Sweden)

    Luís Rafael Moscote Salazar

    2013-10-01

    Full Text Available  Resumen La cervicobraquialgia es el dolor cervical irradiado a una de las extremidades superiores. Es un síndrome clínico que puede estar causado por diversas patologías. El síndrome de Coob consiste en la asociación de una malformación vascular que compromete la piel y malformación vascular de la medula espinal. Presentamos el caso de un paciente con cervicobraquialgia y síndrome de Coob manejado por el Servicio de Neurocirugía del Hospital Universitario CARI en Barranquilla, Colombia. (DUAZARY 2010, 88 - 90AbstractThe cervicobraquialgia is neck pain radiating to the upper extremities. it is a clinical syndrome that can be caused by various pathologies. Cobb syndrome is the association of a vascular malformation that involves the skin and vascular malformation of the spinal cord. We present a patient with cobb syndrome cervicobraquialgia and managed by the department of neurosurgery, university hospital Cari in Barranquilla, Colombia.Keywords: cobb syndrome; cervicobraquialgia; spinal vascular malformation; angiomatosis meningocutaneoespinal.

  8. Niveles de ácido úrico sérico y riesgo de desarrollar preeclampsia

    Directory of Open Access Journals (Sweden)

    Ana I Corominas

    2014-12-01

    Full Text Available Si bien se conoce que existe una asociación entre los niveles elevados de ácido úrico y la preeclampsia, el debate sobre su aplicación clínica aún está abierto. Nuestro objetivo fue estudiar la utilidad del dosaje periódico del ácido úrico sérico durante el embarazo para identificar gestantes con mayor riesgo de desarrollar preeclampsia. Realizamos un estudio retrospectivo en gestantes primíparas: 79 normotensas y 79 con preeclampsia atendidas en el Hospital Nacional Posadas durante el año 2010. Se analizaron los niveles séricos de ácido úrico, creatinina y urea, y los datos de proteinuria de las historias clínicas de las mujeres embarazadas. Los niveles de ácido úrico fueron similares en ambos grupos durante la primera mitad de la gestación. Sin embargo, a partir de la semana 20, el ácido úrico se incrementó 1.5 veces en gestantes preeclámpticas, sin cambios en la uremia y creatininemia, descartándose así el compromiso renal. Además, encontramos que niveles más altos de ácido úrico se correlacionaban con bajo peso del recién nacido. También vimos que las gestantes con antecedentes familiares de hipertensión eran más propensas a desarrollar esta condición. Por otro lado, no observamos una relación directa ni con el sexo fetal ni con el tiempo de aparición de los síntomas clínicos. Estos hallazgos sugieren que los cambios en las concentraciones de ácido úrico se deberían a alteraciones en los estadios iniciales de la preeclampsia. Por ello, la monitorización de los niveles del mismo durante el embarazo podría contribuir al abordaje precoz de este desorden gestacional.

  9. The investigation of relationship between preeclampsia and antiphospholipid antibody syndrome

    Directory of Open Access Journals (Sweden)

    Mehmet Tayyar

    2013-03-01

    Full Text Available Aim. The aim of this study was evaluate the relationship between preeclampsia and antiphospholipid antibodies. Methods. A total of 116 pregnant women between 20th and 40th weeks of gestation admitted to our department were investigated. 63 of them were allocated our preeclampsia group and 53 of them were allocated our control group. Lupus anticoagulant, anti-cardiolipin antibodies (IG G ve M and antiphosphatidylserine antibodies (IG G ve M were measured. Results. There was no statistical significance between preeclampsia and control group for antiphospholipid antibodies but these were two times higher in preeclamptic group compared to control group. (22.2% in preeclampsia, 11.3% in control group p=0.193. Conclusions. In an unselected population we were not able to demonstrate an association between preeclampsia and antiphospholipid antibody syndrome but antiphospholipid antibody ratio elevated in women with preeclampsia. These findings show that, there is a need for large scale studies.

  10. Maternal lipids in pre-eclampsia: innocent bystander or culprit?

    Science.gov (United States)

    Barrett, Helen L; Dekker Nitert, Marloes; McIntyre, H David; Callaway, Leonie K

    2014-11-01

    Pre-eclampsia continues to be a challenge--to understand the underlying pathogenesis and to prevent or treat in the clinical setting. One area of potential therapies opening up is treatment of maternal lipids and clinical trials are underway using statins in early pre-eclampsia. At present, most potential therapies to treat lipids cannot be recommended for general use in pregnancy and if we were to target maternal lipids to reduce rates of pre-eclampsia, very large numbers of women may need to be treated. Prior to reaching that point, we first need to understand whether maternal lipids are pathogenic in the processes underlying pre-eclampsia. The aim of this review is to examine the role of lipids in the pathogenesis and outcomes of pre-eclampsia, how abnormal lipid genes may be implicated and consider whether treatment of hyperlipidemia has a more general place in the prevention or treatment of pre-eclampsia.

  11. Expression of RhoA in Placenta of Preeclampsia

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In order to detect the expression of RhoA in placenta from normal pregnancy and preeclampsia and evaluate the role of RhoA in preeclampsia, the expression of RhoA in placenta collected from 40 preeclampsia patientsand 20 normotensive controls was determined by immunohistochemistry and RT-PCR. RhoA was found in syncytiotrophoblasts and cytotrophoblasts. The mean density of RhoA protein in placental tissues of mild and severe preeclampsia groups was significantly higher than that in normal pregnancy. The expression level of RhoA mRNA in mild and severe preeclampsia groups was significantly higher than that of normal pregnancy. Increased expression of RhoA in placental tissues might play an important role in the pathogenesis of preeclampsia.

  12. The potential participation of abdominal pressure in preeclampsia.

    Science.gov (United States)

    Zhang, Andy K

    2015-06-01

    Preeclampsia is a major cause of maternal and perinatal mortality and morbidity. Regardless of susceptibility or predisposing conditions and risk factors, the degree of increase in abdominal pressure is directly related to the severity of preeclampsia, particularly in women with hydatidiform mole. When increased abdominal pressure is normalized by delivery, preeclampsia is cured. Recent genetic studies highlighted two leading risk factors for preeclampsia: chronic renal disease and T235 homozygosity for the AGT gene. Thus, while there is increased abdominal pressure in pregnancy, an imbalanced renin angiotensin system and renal injuries lead to a vicious cycle of increasing abdominal pressure and further renal injuries. A hypothesis for the potential participation of pressure in preeclampsia is described and the amelioration of preeclampsia through postural intervention and the possible therapeutic effect of angiotensin is suggested.

  13. Biological notes on two species of Oxycorynus (Coleoptera: Belidae associated with parasitic plants of the genus Lophophytum (Balanophoraceae, and new distribution records in Argentina Notas biológicas sobre dos especies de Oxycorynus (Coleoptera: Belidae asociadas con plantas parásitas del género Lophophytum (Balanophoraceae, y nuevos registros de distribución en Argentina

    Directory of Open Access Journals (Sweden)

    María S. Ferrer

    2011-12-01

    Full Text Available This contribution provides new information on the association of weevils of the genus Oxycorynus Chevrolat (Belidae: Oxycoryninae with parasitic plants of the genus Lophophytum Schott & Endl. (Balanophoraceae. New distribution records of Oxycorynus in Argentina are provided.Se brinda nueva información sobre la asociación de gorgojos del género Oxycorynus Chevrolat (Belidae: Oxycoryninae con plantas parásitas del género Lophophytum Schott & Endl. (Balanophoraceae. Se proveen, además, nuevos registros de distribución de Oxycorynus en Argentina.

  14. Early pre-eclampsia unmasks underlying IgA nephropathy

    OpenAIRE

    Mona Singh; Akhenaton Pappoe; Don, Burl R.

    2010-01-01

    Mona Singh, Akhenaton Pappoe, Burl R DonDivision of Nephrology, University of California Davis Medical Center, Sacramento, CA, USAAbstract: Pre-eclampsia is the most ominous complication of pregnancy, and primary glomerular diseases can mimic pre-eclampsia in presentation. A patient presented at 21 weeks gestation with signs and symptoms of both pre-eclampsia and primary glomerular nephropathy. A critical clinical decision whether to continue or terminate the pregnancy was dependent on result...

  15. Thyroid function/antibodies in Sudanese patients with preeclampsia

    Directory of Open Access Journals (Sweden)

    Enaam T Elhaj

    2015-06-01

    Full Text Available Preeclampsia is an important cause of maternal and prenatal morbidity and mortality in the developing countries. Changes in thyroid function/antibodies profiles in preeclamptic women are controversial and were never investigated before in Sudan.A case-control study was conducted at Medani Hospital, Sudan to investigate thyroid function/antibodies in preeclampsia.The socio-demographic, medical history was gathered using questionnaire. Thyroid hormones (TSH, free T3, T4 anti-TPO and anti-TG antibodies were measured using ELISA.The three groups [controls (55 and mild (68 and severe preeclampsia (55] were matched in the age and parity. While median (interquartile range of TSH was significantly lower, the free level of both T3 and T4 were significantly higher in women with preeclampsia than in the healthy controls. There was no significant difference in the TSH levels in women with mild and severe preeclampsia. In comparison with women with mild preeclampsia, women with severe preeclampsia had significantly higher levels of free T3 and significantly lower levels of free T4. While anti -TPO antibodies were significantly higher, anti-TG antibodies were significantly lower in women with preeclampsia. Likewise anti -TPO antibodies were significantly higher and anti-TG antibodies were significantly lower in women with severe preeclampsia than in women with mild preeclampsia. In linear regression, preeclampsia was significantly associated with TSH (−0.675 IU//ml, P = 0.009, free T3 (0.977 pg/ml, P < 0.001 free T4 (0.186 ng/dl, P < 0.001 levels. In contrast to anti-TG antibodies and TSH, Sudanese patient with preeclampsia had higher levels of T3, T4, and anti-TPO antibodies irrespective of parity, gestational age, and hemoglobin levels.

  16. Angiopoietin-related growth factor level in preeclampsia

    OpenAIRE

    2012-01-01

    Abstract Aim. Angiopoietin-related growth factor (AGF) is associated with angiogenesis but it can also affect glucose and energy metabolism. The aim of this study was to determine AGF levels in preeclampsia. Method. The study included 32 women with preeclampsia (preeclampsia group) and 32 non-preeclamptic, healthy, third trimester pregnant women (Control group). We analyzed serum levels of AGF and other biochemical and anthropometric markers in all subjects. Results. Serum AGF levels were sig...

  17. Glomerulonefritis aguda post-infecciosa asociada a neumonía neumocócica Acute post infectious glomerulonephritis associated to pneumococcal pneumonia

    OpenAIRE

    S. Fernández de Miguel; E. de Goicoechea Manzanares; M. Gaboli; J.M. Sánchez Granados; V. Murga Herrera

    2009-01-01

    Presentamos un niño de 6 años con insuficiencia renal aguda secundaria a glomerulonefritis asociada a neumonía neumocócica. El paciente presentó en primer lugar un síndrome nefrítico con hematuria, proteinuria, oliguria, edemas y deterioro de la función renal, siendo diagnosticado a continuación de neumonía con derrame pleural. La función renal se normalizó tras 72 horas, persistiendo una hipertensión arterial que precisó tratamiento en la fase aguda. El cuadro se resolvió sin secue...

  18. Valor de los metodos directos e indirectos de diagnóstico en las micosis sitémicas asociadas al SIDA

    OpenAIRE

    Arechavala,A.I.; A.M. Robles; R. Negroni; Bianchi,M.H.; A. Taborda

    1993-01-01

    Durante 5 años se estudiaron 117 pacientes con micosis sistémicas asociadas al SIDA: 74 criptococosis, 39 histoplasmosis y 4 con ambas enfermedades. Para el diagnóstico analizamos los siguientes materiales: escarificaciones de lesiones cutáneas o mucosas, aspirados de médula ósea, secreciones bronquiales, biopsias de diversos órganos, líquido cefalorraquídeo, hemocultivos y sueros para determinaciones serológicas. Fueron estudiadas en total 203 muestras de pacientes con histoplasmosis, el 46....

  19. Preeclampsia: Short-term and Long-term Implications.

    Science.gov (United States)

    Pauli, Jaimey M; Repke, John T

    2015-06-01

    Preeclampsia is a hypertensive disorder that affects 4% of pregnancies and has a high risk of maternal, fetal, and neonatal morbidity and mortality, as well as long-term cardiovascular risk. Recent updates in the definition, diagnosis, and management guidelines for preeclampsia warrant review by general obstetrician-gynecologists. Screening and prevention algorithms for preeclampsia are available, but ultimately the cure remains delivery of the fetus and placenta. Close monitoring for the development and worsening of preeclampsia during pregnancy is essential to optimize both maternal and fetal/neonatal outcomes.

  20. [Preeclampsia--two manifestations of the same disease].

    Science.gov (United States)

    Kornacki, Jakub; Skrzypczak, Jana

    2008-06-01

    Preeclampsia, due to its complicated and unexplained pathophysiology, remains one of the most difficult subjects in modern maternal-fetal medicine. Despite of the fact that diagnostic criteria of preeclampsia are clear and homogenous, the clinical manifestation of the disease, the prognosis and the frequency of maternal and fetal complications differ considerably among the cases. The aim of the review was to emphasize the heterogenous character of preeclampsia which may be manifested in two different clinical forms--a maternal and placental one. The maternal preeclampsia occurs mostly in multiparous patients with known risk factors of preeclampsia such as: 1) insulin resistance, 2) diabetes mellitus, 3) dyslipidemia, 4) obesisty, and 5) chronic hypertension. The placental form of the disease is more common among nulliparous women without prior risk factors of preeclampsia. The main clinical differences between the two forms are: 1) an earlier onset of placental preeclampsia in most cases, and 2) a more frequent presence of placental insufficiency in placental preeclampsia. The following article focuses on both forms of preeclampsia in the aspect of different clinical manifestations, different prognosis, as well as different management of the disease.

  1. Encefalopatía Asociada A Trastornos Renales En Perros y Gatos: Revisión Bibliográfica

    OpenAIRE

    Pellegrino, Fernando Carlos

    2009-01-01

    La encefalopatía asociada a trastornos renales es una condición mal defi nida, reportada infrecuentemente en perros y gatos con insufi ciencia renal. Esta categoría de encefalopatía metabólica incluye la encefalopatía urémica, el síndrome de desequilibrio de diálisis, la demencia dialítica y la encefalitis postrasplante. Los trastornos de la conciencia y la actividad convulsiva son anormalidades típicas de este trastorno. Otros signos clínicos pueden incluir tremores musculare...

  2. Espondilolistesis traumática del axis asociada a fractura de odontoides: a propósito de un caso

    OpenAIRE

    Lozano Requena, J.A.; Pina Medina, A.; Boronat Pérez, J.; Puchol Castillo, E.

    1992-01-01

    Se presentan dos casos de espondilolistesis traumática del axis, tipo I de Effendi, asociadas a fractura de odontoides. En ninguno de los casos fue necesario realizar tratamiento quirúrgico, consiguiendo la consolidación de ambas fracturas mediante inmovilización con halo-chaleco. Two new case s of traumatic spondylolisthesis of the axis, Effendi's type I, associated to fracture of the odontoid process are reported. Surgical treatment wa s not necessary in any of the cases. ...

  3. Patrón de las alteraciones dentales asociadas a la impactación del canino maxilar por palatino

    OpenAIRE

    Olivera Aguilar, Esther

    2015-01-01

    La tesis doctoral se ha realizado para poder encontrar un método de diagnóstico precoz de la impactación del canino maxilar por palatino, mediante la detección temprana de otras alteraciones dentales asociadas y así poder aplicar tratamientos tempranos, que mejoren el pronóstico de la impactación del canino maxilar por palatino. La impactación del canino maxilar por palatino, supone la alteración del trayecto eruptivo del mismo, que lo conduce a la zona palatina. Los pacientes con esta altera...

  4. Pancreatic Necrosis Associated with Preeclampsia-Eclampsia

    Directory of Open Access Journals (Sweden)

    Parmar MS

    2004-03-01

    Full Text Available CONTEXT: Acute pancreatitis during pregnancy is rare and commonly occurs in association with biliary disease. Preeclampsia is associated with microvascular abnormalities that may involve cerebral, placental, hepatic, renal and splanchnic circulation and rarely can cause acute pancreatitis. CASE REPORT: A case of acute pancreatitis in a patient with preeclampsia-eclampsia where the diagnosis was missed initially that resulted in a protracted course and development of organized pancreatic necrosis. The pancreatic necrosis resolved with conservative management over 8 weeks. CONCLUSIONS: The development of severe hypoalbuminemia, out of proportion to proteinuria, hypocalcemia and findings of capillary leak should alert the physician to search for other inflammatory causes, including acute pancreatitis so that early and effective management be given to avoid complications.

  5. Pre-eclampsia, diagnosis and treatment.

    Science.gov (United States)

    Sunanda, G V; Johanson, R

    2001-11-01

    Pre-eclampsia is a multisystem disorder of pregnancy usually associated with raised blood pressure (BP) and proteinuria. The pathogenesis is not understood despite decades of research. Abnormal placentation related to immune mechanisms and maladaptation of the placenta may be the first step in the development of the disease. Although there are a number of risk factors and new innovatory tests (e.g., uterine artery Doppler) which can be used to predict pre-eclampsia, none fulfils standard diagnostic criteria. Of possible prophylactic value are antiplatelet agents, calcium supplementation and vitamins C and E. Prevention of eclampsia with magnesium sulfate is the subject of a current international randomised controlled trial (RCT), known as MAGPIE. Therapeutic strategies include avoidance of hypertensive injury and delivery of the baby and placenta. Further research into specific antihypertensive agents and conservative management strategies is required.

  6. Lipoproteína (a está associada com níveis basais de insulina em pacientes com Diabetes Mellitus tipo 2 Lipoproteína (a está asociada a niveles basales de insulina en pacientes con Diabetes Mellitus tipo 2 Lipoprotein (a is associated with basal insulin levels in patients with type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Syed Shahid Habib

    2009-07-01

    Full Text Available FUNDAMENTO: Ainda não foi claramente estabelecido se a resistência/deficiência insulínica leva diretamente à aterogênese ou através de sua associação com outros fatores de risco como os níveis de lipoproteína (a[Lp(a]. OBJETIVO: O objetivo do estudo foi estabelecer a relação entre os níveis basais de insulina, lípides e lipoproteína (a em pacientes com diabetes mellitus (DM tipo 2. MÉTODOS: Amostras de sangue foram colhidas em jejum e os níveis de insulina, lipoproteína (a, colesterol total (CT, triglicérides (TG, lipoproteína de baixa densidade (LDL-C, lipoproteína de alta densidade (LDL-C, glicose e hemoglobina glicada (HbA1c foram medidos em 60 pacientes com DM tipo 2 e 28 indivíduos saudáveis. Nós dividimos os pacientes em dois grupos baseados nos níveis basais de insulina: > 10 µIU/ml e 10 µIU/ml comparados com aqueles que apresentavam insulina basal FUNDAMENTO: Todavía no se aclaró totalmente si la resistencia/deficiencia insulínica lleva directamente a la aterogénesis o a través de su asociación con otros factores de riesgo como los niveles de lipoproteína (a [Lp(a]. OBJETIVO: : El objetivo del estudio fue establecer la relación entre los niveles basales de insulina, lípidos y lipoproteína (a en pacientes con diabetes mellitus (DM tipo 2. MÉTODOS: Se extrajeron muestras de sangre en ayuno y se determinaron los niveles de insulina, lipoproteína (a, colesterol total (CT, triglicéridos (TG, lipoproteína de baja densidad (LDL-C, lipoproteína de alta densidad (LDL-C, glucosa y hemoglobina glicosilada (HbA1c en 60 pacientes con DM tipo 2 y 28 individuos sanos. Dividimos a los pacientes en dos grupos basados en los niveles basales de insulina: > 10 µIU/ml y 10 µIU/ml comparados con aquellos que presentaban insulina basal BACKGROUND: It has not been clearly established whether insulin resistance/deficiency leads directly to atherogenesis or through its association with other risk factors such as

  7. Is ethnicity a risk factor for developing preeclampsia? An analysis of the prevalence of preeclampsia in China.

    Science.gov (United States)

    Xiao, J; Shen, F; Xue, Q; Chen, G; Zeng, K; Stone, P; Zhao, M; Chen, Q

    2014-11-01

    Preeclampsia is a major complication of pregnancy. Risk factors for preeclampsia include population and regional ethnicity. Chinese women living outside the Chinese mainland have a lower prevalence of preeclampsia than resident Caucasians. We performed a retrospective study to identify potential factors that may be associated with developing preeclampsia in China. A total of 67,746 pregnant women were included in this study from 2002 to 2011. Data included maternal age, maternal body mass index (BMI), age at marriage, parity, gestation and blood pressure at diagnosis, proteinuria, and birth weight. In the study period, 1301 (1.92%) nulliparous women developed preeclampsia. The prevalence of mild or severe preeclampsia was 1.42% or 0.49%, respectively. The average BMI was 21.61 kg m(-2). On the basis of the WHO BMI classification, 78.8% of women were of normal BMI, 18.3% were overweight and 2.9% were obese. A total of 37.8% of preeclamptic women had lived with the same partner for less than 1 year, which was significantly higher than those healthy pregnant women who did not develop preeclampsia (24.2%). The prevalence of preeclampsia in China is low compared with Caucasians, and the contribution to this lower prevalence may be dependent on BMI or lifestyle including period of cohabitation with the partner. Our data suggest that Chinese ethnicity may be a factor responsible for the low risk of developing preeclampsia in the populations studied.

  8. EVALUACIÓN PRELIMINAR DE LAS PATOLOGÍAS CUTÁNEAS ASOCIADAS CON LA ACLIMATACIÓN EN CAUTIVERIO DEL “CAPITÁN DE LA SABANA”, Eremophilus mutisii Preliminary Evaluation of Skin Pathology Associated with Captivity Aclimatation of “Capitán de la Sabana”, Eremophilus mutisii

    Directory of Open Access Journals (Sweden)

    A RODRÍGUEZ

    Full Text Available El objetivo de este estudio fue investigar las causas que provocan ulceraciones mortales en capitanes de la sabana, Eremophilus mutisii, provenientes del embalse de Fúquene, departamento de Cundinamarca, Colombia (05°28’N 73°44’W, sometidos a cautiverio. De un lote de 53 peces se tomaron diez animales a los cuales se les realizaron, estudios clínicos, bacteriológicos, e histopatológicos de las úlceras durante ocho días, igualmente se realizó un antibiograma. Tanto en las lesiones como en el agua se aislaron bacterias Pseudomona spp. y Escherichia coli, resistentes a amoxicilina y sensibles a ciprofloxacina, norfloxacina, furazolidona y tetraciclina. El análisis histológico demostró necrosis de la epidermis y de los tejidos dérmicos subyacentes, e hiperplasia de las laminillas branquiales. El cuadro patológico se asocia con factores de estrés. Se sugiere realizar estudios adicionales sobre la etiología de la enfermedad y diseñar planes profilácticas con el fin de minimizar las pérdidas de los peces en cautiverio, los cuales exceden el 50% de los animales capturados.The aim of the present study was to explore the etiology of mortal ulcerations in “capitán de la sabana”. Fishes were captured from Fúquene Lake, Cundinamarca department, Colombia (05°28’N 73°44’W and stocked in 100 L glass tanks in captivity. Ten fishes with skin ulcers were kept in an independent tank and changes in morphology, bacterial flora and organization of tissues were evaluated by means of bacteriology and histology techniques during eight days. Cultures for bacteria were done from the skin ulcers and from the tank water, and an antibiogram was carried out. The analysis showed the presence of common bacteria in the water flora and ulcers: Pseudomona spp. and Escherichia coli, resistant to the amoxicilin and sensitive to the ciprofloxacin, norfloxacin, furazolidon and tetraciclin. The histology demonstrated necrosis of the epidermis and

  9. Evaluación preliminar de las patologías cutáneas asociadas con la aclimatación en cautiverio del “capitán de la sabana”, Eremophilus mutisii Preliminary Evaluation of Skin Pathology Associated with Captivity Aclimatation of “Capitán de la Sabana”, Eremophilus mutisii

    Directory of Open Access Journals (Sweden)

    Rodríguez A.

    2005-12-01

    Full Text Available El objetivo de este estudio fue investigar las causas que provocan ulceraciones mortales en capitanes de la sabana, Eremophilus mutisii, provenientes del embalse de Fúquene, departamento de Cundinamarca, Colombia (05°28'N 73°44'W, sometidos a cautiverio. De un lote de 53 peces se tomaron diez animales a los cuales se les realizaron, estudios clínicos, bacteriológicos, e histopatológicos de las úlceras dur ante ocho días, igualmente se realizó un antibiograma. Tanto en las lesiones como en el agua se aislaron bacterias Pseudomona spp. y Escherichia coli, resistentes a amoxicilina y sensibles a ciprofloxacina, norfloxacina, furazolidona y tetraciclina. El análisis histológico demostró necrosis de la epidermis y de los tejidos dérmicos subyacentes, e hiperplasia de las laminillas branquiales. El cuadro patológico se asocia con factores de estrés. Se sugiere realizar estudios adicionales sobre la etiología de la enfermedad y diseñar planes profilácticas con el fin de minimizar las pérdidas de los peces en cautiverio, los cuales exceden el 50% de los animales capturados.The aim of the present study was to explore the etiology of mortal ulcerations in "capitán de la sabana". Fishes were captured from Fúquene Lake, Cundinamarca department, Colombia (05°28'N 73°44'W and stocked in 100 L glass tanks in captivity. Ten fishes with skin ulcers were kept in an independent tank and changes in morphology, bacterial flora and organization of tissues were evaluated by means of bacteriology and histology techniques during eight days. Cultures for bacteria were done from the skin ulcers and from the tank water, and an antibiogram was carried out. The analysis showed the presence of common bacteria in the water flora and ulcers: Pseudomona spp. and Escherichia coli, resistant to the amoxicilin and sensitive to the ciprofloxacin, norfloxacin, furazolidon and tetraciclin. The histology demonstratednecrosis of the epidermis and underlaying

  10. Factores de riesgo para la preeclampsia severa y temprana en el Hospital General de Medellín (HGM 1999-2001

    Directory of Open Access Journals (Sweden)

    Mercedes Jimeno

    2001-04-01

    Full Text Available Se ha calculado, por estudios en otras partes del mundo, que la
    frecuencia de presentación del Síndrome Hipertensivo del embarazo
    oscila entre 7% y 10% de los embarazos, y que el 30% corresponde a Preeclampsia y de éstos, menos del 10% a Preeclampsia temprana. Entre los factores maternos, uno de los que más peso ha tenido es la paridad materna y en segundo lugar la edad materna. Además, también se ha encontrado asociación con el antecedente de hipertensión esencial. Se pretendió con este estudio evaluar si la presencia de factores de riesgo en esta población se relaciona con la presentación del síndrome en sus formas severas y con las formas tempranas del mismo.

  11. Cesariana em paciente com doença de von Willebrand associada à infecção pelo HIV: relato de caso Cesárea en paciente con enfermedad de von Willebrand asociada a la infección por el HIV: relato de caso Anesthesia for cesarean section in patient with von Willebrand's disease and HIV infection: case report

    Directory of Open Access Journals (Sweden)

    Vanessa Rezende Balle

    2004-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A doença de von Willebrand é a alteração inata da coagulação mais freqüente em mulheres jovens. A infecção por HIV tem mostrado incidência progressivamente maior em mulheres, constatando-se transmissão vertical em até 25% dos casos. O objetivo deste relato é mostrar o caso de uma paciente com doença de von Willebrand e HIV positivo submetida à cesariana. RELATO DO CASO: Paciente de 24 anos, portadora de anemia microcítica, doença de von Willebrand e HIV, chegou à emergência obstétrica em início de trabalho de parto. Não realizou pré-natal. Foi indicada cesariana a fim de diminuir os riscos de transmissão vertical em paciente com carga viral de HIV desconhecida. Apresentava hematomas pelo corpo e história de hematoma de parede abdominal em cesariana anterior. Os testes de coagulação eram pouco alterados. Após infusão de concentrado de fator VIII foi realizada anestesia geral. Mãe e recém-nascido apresentaram evolução satisfatória. CONCLUSÕES: A avaliação de manifestações clínicas em pacientes com coagulopatia é fundamental na decisão do tipo de anestesia a ser indicada para cada paciente. A avaliação deve ser individualizada, considerando os riscos e benefícios da técnica escolhida. Nestas pacientes, deve-se sempre restringir ao máximo a indicação de interrupção da gestação por via alta, optando-se sempre pelos métodos menos invasivos. A terapia com concentrado de fator VIII é atualmente a melhor opção de tratamento, corrigindo a deficiência específica e diminuindo os riscos de transmissão viral.JUSTIFICATIVA Y OBJETIVOS: La enfermedad de von Willebrand es la alteración innata de la coagulación más frecuente en mujeres jóvenes. La infección por HIV ha mostrado incidencia progresivamente mayor en mujeres, constatandose transmisión vertical en hasta 25% de los casos. El objetivo de este relato es mostrar el caso de una paciente con Enfermedad de von

  12. LncRNAs expression in preeclampsia placenta reveals the potential role of LncRNAs contributing to preeclampsia pathogenesis.

    Directory of Open Access Journals (Sweden)

    Xiaoju He

    Full Text Available BACKGROUND: Long non-coding RNAs (lncRNAs are an important class of pervasive genes involved in a variety of biological functions. They are aberrantly expressed in many types of diseases. In this study, we aimed to investigate the lncRNA profiles in preeclampsia. Preeclampsia has been observed in patients with molar pregnancy where a fetus is absent, which demonstrate that the placenta is sufficient to cause this condition. Thus, we analyzed the lncRNA profiles in preeclampsia placentas. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we described the lncRNA profiles in six preeclampsia placentas (T and five normal pregnancy placentas (N using microarray. With abundant and varied probes accounting for 33,045 LncRNAs in our microarray, 28,443 lncRNAs that were expressed at a specific level were detected. From the data, we found 738 lncRNAs that were differentially expressed (≥ 1.5-fold-change among preeclampsia placentas compared with controls. Coding-non-coding gene co-expression networks (CNC network were constructed based on the correlation analysis between the differentially expressed lncRNAs and mRNAs. According to the CNC network and GO analysis of differentially expressed lncRNAs/mRNAs, we selected three lncRNAs to analyze the relationship between lncRNAs and preeclampsia. LOC391533, LOC284100, and CEACAMP8 were evaluated using qPCR in 40 preeclampsia placentas and 40 controls. These results revealed that three lncRNAs were aberrantly expressed in preeclampsia placentas compared with controls. CONCLUSIONS/SIGNIFICANCE: Our study is the first study to determine the genome-wide lncRNAs expression patterns in preeclampsia placenta using microarray. These results revealed that clusters of lncRNAs were aberrantly expressed in preeclampsia placenta compared with controls, which indicated that lncRNAs differentially expressed in preeclampsia placenta might play a partial or key role in preeclampsia development. Misregulation of LOC391533, LOC

  13. ESPECTRO CLÍNICO DE LA PREECLAMPSIA: ESTUDIO COMPARATIVO DE SUS DIVERSOS GRADOS DE SEVERIDAD

    OpenAIRE

    Parra C,Mauro; San Martín O,Alfredo; Valdés R,Enrique; Hasbún H,Jorge; Quiroz V,Lorena; Schepeler S,Manuel; Pérez B,Sebastián; Rau M,Carlos; Miranda 0,Juan Pablo

    2007-01-01

    Objetivo: Comparar los resultados maternos y perinatales en embarazadas que cursaron con preeclampsia (PE) en sus diversas presentaciones en el período 2001 -2005. Material y Método: Estudio retrospectivo de 7.205 partos asistidos en la maternidad del Hospital Clínico de la Universidad de Chile. 204 mujeres presentaron PE/eclampsia, dividiéndose en 3 grupos: PE modera, severa y síndrome de HELLP. Se analizaron las variables clínicas y de laboratorio de la embarazada y del recién nacido. Se co...

  14. Diseño de intervención ante una de las problemáticas asociadas al Absentismo Escolar: la falta de motivación escolar

    OpenAIRE

    Armesto Arias, Marta

    2014-01-01

    Diseño de intervención con tres colectivos (padres y madres, alumnos y alumnas y profesorado), ante una de las problemáticas asociadas al Absentismo Escolar en la ciudad de Gijón como es la falta de motivación escolar.

  15. Características do apoio social associados à prematuridade em uma população de puérperas de baixa renda Características del apoyo social asociadas con la prematuridad en una población de madres de bajos ingresos Characteristics of social support associated with prematurity in a population of mothers of low income

    Directory of Open Access Journals (Sweden)

    Elaine da Costa Guimarães

    2011-03-01

    Full Text Available Trata-se de um estudo caso-controle que teve como objetivo investigar a associação entre prematuridade e o nível de apoio social, segundo variáveis socioeconômicas, demográficas e relacionadas à saúde e à assistência, em uma população de puérperas de baixa renda atendidas em um hospital público do município do Rio de Janeiro. Foram entrevistados 108 casos e 228 controles, em um total 336 mulheres. A idade das mulheres variou entre 14 e 45 anos. A média da idade foi de 25,8 anos (desvio-padrão: 6,9 para os casos e de 24,9 (desvio-padrão 6,5 para os controles. Quanto à raça/etnia autorreferida, 77,1% denominaram-se não brancas. Da amostra, 68,8% iniciaram o pré-natal antes do terceiro trimestre gestacional. O número de consultas durante o pré-natal, ocorrência de ameaça de parto prematuro e história de prematuridade anterior mostraram-se associados ao nível de apoio, calculado a partir do escore total das dimensões do apoio social.Se trata de un estudio caso-control cuyo objetivo fue investigar la asociación entre el nacimiento prematuro y el nivel de apoyo social, según indicadores socioeconómicos, demográficos y de asistencia relacionados con la salud y, en una población de madres de bajos ingresos que asisten a un hospital público en la ciudad de Río de Janeiro. Fueron analizados 108 casos y 228 controles, de un total de 336 mujeres. Las edades de las mujeres oscilaron entre 14 y 45 años. La edad media fue de 25,8 años (desviación estándar: 6,9 para los casos y el 24,9 (desviación estándar de 6,5 para los controles. En cuanto a la raza/origen étnico auto-reportado 77,1% se denominaron no blancos. El 68,8% comenzó la atención prenatal antes del tercer trimestre de embarazo. El número de visitas durante el período prenatal, ocurrencia de amenaza de parto prematuro y antecedentes de prematuridad se asociaron con el nivel de apoyo, se calcularon a partir de la puntuación total de las dimensiones de

  16. Gene expression profiling of placentas affected by pre-eclampsia

    DEFF Research Database (Denmark)

    Hoegh, Anne Mette; Borup, Rehannah; Nielsen, Finn Cilius;

    2010-01-01

    Several studies point to the placenta as the primary cause of pre-eclampsia. Our objective was to identify placental genes that may contribute to the development of pre-eclampsia. RNA was purified from tissue biopsies from eleven pre-eclamptic placentas and eighteen normal controls. Messenger RNA...

  17. Serum lipid levels in pregnancies complicated by preeclampsia

    Directory of Open Access Journals (Sweden)

    Valmir Jose de Lima

    Full Text Available CONTEXT AND OBJECTIVE: Pre-eclampsia is a disorder that occurs only during pregnancy. Postpartum changes relating to lipid metabolism may contribute towards the endothelial lesions observed in preeclampsia. Thus, the aim of the present study was to evaluate the lipid profile among patients who present preeclampsia and correlate these parameters with 24-hour proteinuria. DESIGN AND SETTING: Cross-sectional analytical study including 77 pregnant patients seen at Hospital Dório Silva. METHODS: This study involved 42 women with preeclampsia and 35 healthy pregnant women in the third trimester of pregnancy as controls. Blood samples were obtained from all the patients, and the serum levels of triglycerides, total cholesterol, low-density lipoproteins (LDL, high-density lipoproteins (HDL and very low density lipoproteins (VLDL were determined. Cases and controls were matched for maternal age, gestational week and body mass index. RESULTS: The VLDL and triglyceride values from the women with preeclampsia were significantly higher than those of the healthy women. There was a positive correlation between increased proteinuria and higher VLDL and triglyceride levels in patients with preeclampsia. CONCLUSION: Among the patients with preeclampsia, higher VLDL and triglyceride levels were positively correlated with proteinuria. These observations indicate that the pregnant women who presented elevated lipid levels were more susceptible to cardiovascular disorders and, consequently, pre-eclampsia.

  18. Association between Asymptomatic Bacteriuria and Pre-Eclampsia.

    Science.gov (United States)

    Rezavand, Negin; Veisi, Firooze; Zangane, Mrayam; Amini, Roghaye; Almasi, Afshin

    2015-12-18

    Asymptomatic bacteriuria is one of the most common and important bacterial infections during pregnancy and can result in progressive infections and endanger maternal as well as fetal health. In this study, we assessed the relationship between asymptomatic bacteriuria and pre-eclampsia. In this case-control study, pregnant women who presented to Imam Reza Hospital in Kermanshah in 2013-14 were studied. The minimum sample size was calculated as 125 pregnant women in each group with a total of 250 subjects. There were 125 women with pre-eclampsia and 125 women without pre-eclampsia (control group). Matching was done for age, gestational age, and parity between case and control groups. Matching was verified by a P value of 0.061 for maternal age and gestational age and 0.77 for parity. The statistical analyses were done by applying the chi-squared test and determining odds ratio (OR) for having bacteriuria in univariate logistic regression as well as multivariate regression with adjusting the effect of maternal age, gestational age, and parity. Pyuria and bacteriuria were significantly more common in pre-eclampsia group than in control group. The results showed that a significant association existed between asymptomatic bacteriuria and pre-eclampsia. The rate of asymptomatic bacteriuria was 6.8 times higher in women with pre-eclampsia compared to those without pre-eclampsia. Further studies are required for better clarification of association between asymptomatic bacteriuria and pre-eclampsia.

  19. Monocytes and macrophages in pregnancy and pre-eclampsia

    NARCIS (Netherlands)

    Faas, Marijke M.; Spaans, Floor; De Vos, Paul

    2014-01-01

    Preeclampsia is an important complication in pregnancy, characterized by hypertension and proteinuria in the second half of pregnancy. Generalized activation of the inflammatory response is thought to play a role in the pathogenesis of pre-eclampsia. Monocytes may play a central role in this inflamm

  20. Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia.

    Science.gov (United States)

    Silasi, Michelle; Cohen, Bruce; Karumanchi, S Ananth; Rana, Sarosh

    2010-06-01

    Preeclampsia is a common complication of pregnancy with potentially devastating consequences to both the mother and the baby.It is the leading cause of maternal deaths in developing countries. In developed countries it is the major cause of iatrogenic premature delivery and contributes significantly to increasing health care cost associated with prematurity. There is currently no known treatment for preeclampsia; ultimate treatment involves delivery of the placenta. Although there are several risk factors (such as multiple gestation or chronic hypertension), most patients present with no obvious risk factors. The molecular pathogenesis of preeclampsia is just now being elucidated. It has been proposed that abnormal placentation and an imbalance in angiogenic factors lead to the clinical findings and complications seen in preeclampsia. Preeclampsia is characterized by high levels of circulating antiangiogenic factors such as soluble fms-like tyrosine kinase-1 and soluble endoglin, which induce maternal endothelial dysfunction. These soluble factors are altered not only at the time of clinical disease but also several weeks before the onset of clinical signs and symptoms. Many methods of prediction and surveillance have been proposed to identify women who will develop preeclampsia, but studies have been inconclusive. With the recent discovery of the role of angiogenic factors in preeclampsia, novel methods of prediction and diagnosis are being developed to aid obstetricians and midwives in clinical practice. This article discusses the role of angiogenic factors in the pathogenesis, prediction, diagnosis, and possible treatment of preeclampsia.

  1. Preeclampsia and its interaction with common variants in thrombophilia genes

    NARCIS (Netherlands)

    Maat, M.P.M. de; Jansen, M.W.J.C.; Hille, E.T.M.; Vos, H.; Bloemenkamp, K.W.M.; Buitendijk, S.E.; Helmerhorst, F.M.; Wladimiroff, J.W.; Bertina, R.M.; Groot, C.J.M. de

    2004-01-01

    Recently, it has been proposed that abnormalities in coagulation and fibrinolysis contribute to the development of preeclampsia by increasing the thrombotic tendency. This hypothesis was tested in women who have had preeclampsia (cases) compared with matched controls. Polymorphisms in the thrombophi

  2. Pulse wave analysis for the prediction of preeclampsia.

    Science.gov (United States)

    Carty, D M; Neisius, U; Rooney, L K; Dominiczak, A F; Delles, C

    2014-02-01

    Preeclampsia is associated with a number of changes to maternal vascular function. Assessment of arterial stiffness using pulse wave analysis (PWA) has been proposed as a means of predicting preeclampsia before the onset of clinically detectable disease. One hundred and eighty women with 2 risk factors for preeclampsia were examined at gestational weeks 16 and 28, of whom 17 (9.4%) developed preeclampsia. To study the effects of pregnancy itself women were also examined at 6-9 months post-natally; an additional 30 healthy non-pregnant women were also examined. PWA was performed using SphygmoCor; augmentation index (AIx), a marker of arterial wave reflection, was also measured using EndoPAT-2000. Women who developed preeclampsia were more likely to be overweight and had a higher brachial and central diastolic BP at gestational week 16 than those who remained normotensive. There was no difference in any parameter of arterial wave reflection between non-pregnant and pregnant women, nor between those who developed preeclampsia and those who remained normotensive, when examined at weeks 16 and 28 or post-natally. In this cohort of women with risk factors for preeclampsia, PWA did not provide additional information beyond brachial blood pressure and maternal risk factor profile about the risk of future development of preeclampsia.

  3. Increased intima-media thickness after early-onset preeclampsia

    NARCIS (Netherlands)

    Blaauw, Judith; van Pampus, Maria G; Van Doormaal, Jasper J; Fokkema, M Rebecca; Fidler, Vaclav; Smit, Andries J; Aarnoudse, Jan G

    2006-01-01

    OBJECTIVE: Preeclampsia is associated with cardiovascular atherosclerotic events later in life. However, little is known about earlier subdinical signs of atherosclerosis. We aimed to investigate whether women who recently had preeclampsia show increased intima-media thickness (IMT), as marker of ea

  4. Leukocyte Activation and Circulating Leukocyte-Derived Microparticles in Preeclampsia

    NARCIS (Netherlands)

    Lok, Christianne A. R.; Jebbink, Jiska; Nieuwland, Rienk; Faas, Marijke M.; Boer, Kees; Sturk, Augueste; Van Der Post, Joris A. M.

    2009-01-01

    Preeclampsia shows characteristics of an inflammatory disease including leukocyte activation. Analyses of leukocyte-derived microparticles (MP) and mRNA expression of inflammation-related genes in leukocytes may establish which subgroups of leukocytes contribute to the development of preeclampsia. B

  5. Studies on Activity of NK Cells in Preeclampsia Patients

    Institute of Scientific and Technical Information of China (English)

    张展; 龚非力; 贾莉婷; 常彩红; 侯磊; 杨如镜; 郑芳

    2004-01-01

    The activity of the NK cells in patients with preeclampsia was studied to investigate the pathogenesis of preeclampsia. By using MTT and 51Cr releasing technique, the proliferation and killing ability of the NK cells in maternal and umbilical blood from preeclampsia patients (n= 18)and normal third trimester pregnant women (n= 18) were detected. The NK-92 cell line was as the positive control. The results showed that the NK cell counts of umbilical blood in preeclampsia patients and normal third trimester pregnant women were significantly greater than those of maternal blood (both P<0.05). Compared with that in normal third trimester pregnant women, the proliferative ability of the NK cells in preeclampsia patients was apparently increased (P<0.05). Compared with that in maternal blood, the proliferative ability of the NK cells in umbilical blood from both preeclampsia patients and normal third trimester pregnant women was dramatically increased.The killing ability of the NK cells in preeclampsia patients was significantly higher than that in normal third trimester pregnant women (P <0.05). It was suggested that both number and function of the NK cells in preeclampsia women were increased, and that in umbilical blood was greater than that in maternal blood, speculating that the function of the NK cells may affect the maintenance of the maternal and fetal immune tolerance during pregnancy.

  6. Counselling and management of cardiovascular risk factors after preeclampsia

    NARCIS (Netherlands)

    Van Kesteren, Floortje; Visser, Sanne; Hermes, Wietske; Teunissen, Pim W.; Franx, Arie; Van Pampus, Maria G.; Mol, Ben W.; De Groot, Christianne J M

    2016-01-01

    Objective: Women with a history of preeclampsia have an increased risk of cardiovascular disease. Gynaecologists have an important role in the counselling and management of cardiovascular risk factors after preeclampsia. We aimed to assess the role of gynaecologists in informing women on interventio

  7. Treatment of preeclampsia: current approach and future perspectives.

    Science.gov (United States)

    Berzan, Ecaterina; Doyle, Ross; Brown, Catherine M

    2014-09-01

    Hypertension is the most common medical disorder encountered during pregnancy, occurring in about 6-8 % of pregnancies. Preeclampsia is a pregnancy-specific disorder that occurs after 20 weeks' gestation, characterized by hypertension and proteinuria. Preeclampsia can also occur superimposed upon chronic hypertension. Eclampsia is the convulsive form of preeclampsia, and affects 0.1 % of all pregnancies. In low-income and middle-income countries, preeclampsia and eclampsia are associated with 10-15 % of direct maternal deaths. Women who develop preeclampsia in pregnancy are at greater risk of cardiovascular and cerebrovascular events even years after their pregnancies. There is significant progress in the elucidation of the underlying mechanisms and pathophysiology of preeclampsia, although its therapeutics remains challenging; delivery of the fetus is still the definitive treatment. Different international societies have produced recommendations and guidelines for clinicians treating preeclampsia, with an overall goal of improving maternal and fetal outcomes. In this review, we focus on the level of blood pressure at which to commence treatment and the current clinical management strategies available to treat and possibly prevent preeclampsia. We also briefly outline some newer perspectives on management of the disorder.

  8. Periodontal disease and pre-eclampsia : a systematic review

    NARCIS (Netherlands)

    Kunnen, Alina; van Doormaal, Jasper J.; Abbas, Frank; Aarnoudse, Jan G.; van Pampus, Maria; Faas, Marijke M.

    2010-01-01

    P>Aim This review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state, period

  9. Resultados a largo plazo del tratamiento antiangiogénico en la degeneración macular asociada en la edad en la práctica clínica diaria

    OpenAIRE

    Rodríguez Nicho, Hernán Vicente

    2012-01-01

    Nuestro Objetivo es conocer los resultados a largo plazo en los pacientes con DMAE exudativa tratados con Antiangiogénicos en la práctica clínica diaria. Estudio retrospectivo, transaccional y descriptivo mediante una revisión de Historias Clínicas. Se incluyeron a pacientes con DMAE exudativa tratados con AAGs cuyo comienzo del tratamiento fue antes del 31 de Diciembre de 2008. Se excluyeron a aquellos con patología asociada que pudiera producir disminución de agudeza visual, excepto catara...

  10. Serum homocysteine in pre-eclampsia and eclampsia.

    Science.gov (United States)

    Hoque, Md Mozammel; Bulbul, Tania; Mahal, Monzarin; Islam, Nur-A-Farzana; Ferdausi, Munira

    2008-04-01

    Pre-eclampsia and eclampsia are common obstetrical problem causing adverse effects on pregnancy outcome. Large bodies of evidences suggest that hyperhomocysteinemia is a causal factor of pre-eclampsia/eclampsia. This study designed to explore the association between hyperhomocysteinemia and pre-eclampsia/eclampsia, the knowledge of which expected to be used for prevention of pre-eclampsia and eclampsia. In a case-control study serum homocysteine was measured in 136 controls (healthy pregnant), 84 pre-eclamptic and 120 eclamptic pregnant women. Serum homocysteine in patients with pre-eclampsia (9.54 +/- 3.21 micromol/L) and eclampsia (10.57 +/- 3.39 micromol/L) found to be significantly increased compared to controls (6.86 +/- 2.47 micromol/L) (p homocysteine found to be raised more in eclampsia compared to pre-eclampsia (p homocysteine elevation is more compared to that in pre-eclampsia.

  11. Combined Screening for Early Detection of Pre-Eclampsia.

    Science.gov (United States)

    Park, Hee Jin; Shim, Sung Shin; Cha, Dong Hyun

    2015-08-04

    Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.

  12. Combined Screening for Early Detection of Pre-Eclampsia

    Directory of Open Access Journals (Sweden)

    Hee Jin Park

    2015-08-01

    Full Text Available Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.

  13. Dynamic Cerebral Autoregulation in Pregnancy and the Risk of Preeclampsia

    DEFF Research Database (Denmark)

    Janzarik, Wibke G; Ehlers, Elena; Ehmann, Renata;

    2014-01-01

    Preeclampsia may affect severely the cerebral circulation leading to impairment of cerebral autoregulation, edema, and ischemia. It is not known whether impaired autoregulation occurs before the clinical onset of preeclampsia, and whether this can predict the occurrence of preeclampsia. Seventy......) of respiratory-induced 0.1 Hz hemodynamic oscillations. Uterine artery ultrasound was performed to search for a notch sign as an early marker of general endothelial dysfunction. All women were followed up until 6 weeks after delivery for the occurrence of preeclampsia. The autoregulation parameter gain did...... not differ between pregnant and nonpregnant women. Phase was slightly but significantly higher in pregnant women, indicating better DCA. Women with a notch sign did not show altered DCA. A history of preeclampsia during a previous pregnancy was associated with lower phase in middle cerebral artery...

  14. Preeclampsia Associates with Asthma, Allergy, and Eczema in Childhood

    DEFF Research Database (Denmark)

    Stokholm, Jakob; Sevelsted, Astrid; Anderson, Ulrik D

    2017-01-01

    .55 to -0.06]; P = 0.0348), and allergic rhinitis (adjusted odds ratio, 4.83 [95% CI, 1.58-14.78]; P = 0.0057) in the 7-year-old children. Furthermore, the children had an increased risk of sensitization to both aeroallergens and food allergens, and increased amount of total IgE during childhood......RATIONALE: Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. OBJECTIVES: We studied associations between preeclampsia and asthma, allergy, and eczema in Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and in national registries. METHODS....... In the registry-based cohort, 3.7% (n = 62,728) were born to mothers with preeclampsia. Preeclampsia was associated with increased risk of asthma, eczema, and aeroallergen and food allergy, especially pronounced after a duration of preeclampsia of 14 days or more. Maternal asthma increased the risk...

  15. Preeclampsia -- a state of prostaglandin deficiency? Urinary prostaglandin excretion, the renin-aldosterone system, and circulating catecholamines in preeclampsia.

    Science.gov (United States)

    Pedersen, E B; Christensen, N J; Christensen, P; Johannesen, P; Kornerup, H J; Kristensen, S; Lauritsen, J G; Leyssac, P P; Rasmussen, A; Wohlert, M

    1983-01-01

    Urinary excretion of prostaglandin E2 (PGE2) and F2 alpha (PGF2 alpha), plasma concentrations of renin, aldosterone, norepinephrine (NE) and epinephrine (E) were determined during pregnancy, 5 days, 3, and 6 months after delivery in preeclampsia, normotensive pregnant, and nonpregnant control subjects. The PGE2 was higher in normotensive pregnant control subjects than in nonpregnant subjects. In preeclampsia, PGE2 was reduced to nonpregnant level. PGF2 alpha was the same in preeclampsia and in normotensive pregnancy, but elevated when compared to the normotensive nonpregnant control group. Plasma concentrations of renin and aldosterone were increased during pregnancy, but considerably less in preeclampsia than during normotensive pregnancy. NE and E were the same as in nonpregnant subjects during both hypertensive and normotensive pregnancy. All parameters were normal 3 months after delivery. There were no correlations between PGE2, PGF2 alpha, plasma concentrations of renin, aldosterone, NE, or E and blood pressure level in third trimester either in preeclampsia or in normotensive pregnancy. PGE2 was positively correlated to plasma concentrations of renin. It is suggested that the lack of renal PGE2 in preeclampsia might be responsible for the decrease in renal blood flow and sodium excretion. It is hypothesized that preeclampsia is a state of prostaglandin deficiency. The changes in the renin-aldosterone system may be secondary to changes in prostaglandin concentration both in preeclampsia and normotensive pregnancy.

  16. IFPA Senior Award Lecture: making sense of pre-eclampsia - two placental causes of preeclampsia?

    Science.gov (United States)

    Redman, C W; Sargent, I L; Staff, A C

    2014-02-01

    Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Uncomplicated term pregnancy is associated with increasing sVEGFR-1 and decreasing PlGF, which can be interpreted as evidence of increasing STB stress. STB pathology, at or after term (for example focal STB necrosis) demonstrates this stress, with or without pre-eclampsia. We review the evidence that when placental growth reaches its limits at term, terminal villi become over-crowded with diminished intervillous pore size impeding intervillous perfusion with increasing intervillous hypoxia and STB stress. This type of STB stress has no antecedent pathology, so the fetuses are well-grown, as typifies late onset pre-eclampsia, and prediction is less effective than for the early onset syndrome because STB stress is a late event. In summary, abnormal placental perfusion and STB stress contribute to the pathogenesis of early and late onset pre-eclampsia. But the former has an extrinsic cause - poor placentation, whereas the latter has an intrinsic cause, 'microvillous overcrowding', as placental growth reaches its functional limits. This model explains important features of late pre-eclampsia and raises questions of how antecedent medical risk factors such as

  17. Osteonecrosis de los maxilares asociada al empleo de bifosfonatos Bisphosphonate-associated osteonecrosis of the jaw

    Directory of Open Access Journals (Sweden)

    J.L. del Castillo Pardo de Vera

    2007-10-01

    Full Text Available Los bifosfonatos constituyen un grupo de fármacos inhibidores de la resorción ósea, utilizados en el tratamiento de numerosas patologías como la osteoporosis, la enfermedad de Paget, el mieloma múltiple, la hipercalcemia maligna y las metástasis óseas asociadas al cáncer de mama o de próstata. El principal efecto farmacológico de los bifosfonatos es la inhibición de la resorción ósea, mediante una disminución de la actividad de los osteoclastos, sin intervenir en la formación y mineralización del hueso. Son fármacos utilizados a nivel mundial con unos claros beneficios contrastados clínicamente. Numerosas publicaciones durante los últimos tres años, y debido a su utilización masiva, consideran que la osteonecrosis de los maxilares está asociada al tratamiento con bifosfonatos. Es importante que los pacientes sean informados del riesgo de presentarse esta complicación, para tener la oportunidad de someterse a procedimientos dentales previos al inicio del tratamiento. Las medidas preventivas deben realizarse antes, durante y después del tratamiento con bifosfonatos. El tratamiento quirúrgico debe reservarse para aquellos pacientes que presenten síntomas. Son necesarias nuevas investigaciones que clarifiquen esta complicación.Bisphosphonates constitute a group of inhibitors of bone resorption that are used for treating many disor-ders such as osteoporosis, Paget´s disease, multiple myeloma, malignant hypercalcemia and bone metas-tases associated with breast and prostate cancer. The main pharmacological effect of bisphosphonates is the inhibition of bone resorption, mediated by a decreased function of osteoclasts without interfering in bone formation and mineralization. These drugs are used worldwide, with clear and clinically proven benefits. Several publications within the last three years consider osteonecrosis of the jaw to be associated with bisphosphonate therapy as a result of their extensive use. It is important

  18. Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are neither associated with muscle characteristics nor physical performance in elderly. [Variaciones genéticas en la vía de la mitocondriogénesis PPARD-PPARGC1A-NRF-TFAM no están asociadas ni con características musculares ni con rendimiento físico en personas mayores].

    Directory of Open Access Journals (Sweden)

    Nuria Garatachea

    2015-07-01

    Full Text Available We studied the influence of genetic polymorphisms involved in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway (rs6949152, rs12594956, rs2267668, rs8192678, and rs1937 on muscle phenotypes (thigh muscles’ cross-sectional, maximal handgrip-strength and 30-second chair stand-test and Barthel index in Caucasian (Spanish community-dwelling old people (n=75, 21 men, 54 women; 71–94 years. We found no significant genetic associations with the studied phenotypes. Multiple, complex gene-environment and gene-gene interactions which are yet to be determined are likely to play a more determinant role. Resumen Se estudió la influencia de los polimorfismos genéticos implicados en la vía de mitocondriogénesis PPARD-PPARGC1A-NRF-TFAM (rs6949152, rs12594956, rs2267668, rs8192678 y rs1937 en distintos fenotipos musculares (sección transversal muscular del muslo, fuerza máxima de prensión manual y 30 segundos de sentarse-levantarse de una silla y en el índice de Barthel en personas mayores caucásicas (españoles (n = 75, 21 hombres, 54 mujeres; 71 a 94 años. No se encontraron asociaciones genéticas significativas con los fenotipos estudiados. Interacciones múltiples, complejos gen-ambiente y relaciones gen-gen aún no determinadas podrían desempeñar un papel más determinante.

  19. Reemplazo total de rodilla en gonartrosis asociada a deformidad extraarticular. [Total knee replacement inosteoarthritis associated with extra-articular deformity

    Directory of Open Access Journals (Sweden)

    Hernan del Sel

    2012-12-01

    Full Text Available Introducción El éxito a largo plazo de un reemplazo total de rodilla (RTR depende de la restitución del eje mecánico del miembro, de la correcta colocación del implante y del balance de partes blandas. Los pacientes con gonartrosis asociada a una deformidad extraarticular, femoral o tibial, requieren de una cuidadosa evaluación y planificación preoperatoria con el objeto de decidir si la corrección del eje podrá realizarse mediante la resección ósea intraarticular, o si deberá asociarse una osteotomía extraarticular. Material y Método Se evaluaron 22 RTR (en 20 pacientes por gonartrosis asociada a deformidad extraarticular. La etiología de la deformidad extraarticular fue postraumática en 8 casos y postosteotomía en 14 (8 femorales y 6 tibiales. Resultados En todos los casos se realizó la corrección del eje del miembro mediante un RTR con cortes óseos intra articulares “inusuales”, sin que fuera necesario realizar una osteotomía. La evaluación clínica y funcional se realizó mediante el sistema de puntaje de la Knee Society2. El promedio de la evaluación clínica fue de 24,3 puntos en el prequirúrgico y 86 al año postoperatorio. Con respecto al puntaje funcional, paso de un promedio de 34 puntos en el prequirúrgico a 85,3 puntos al año. Conclusión No hay un criterio único en relación al tratamiento del paciente con gonartrosis sintomática asociada a una deformidad extraarticular. La corrección de la deformidad extraarticular por medio de cortes óseos intraarticulares ¨inusuales¨ es posible si estos no afectan las inserciones ligamentarias femorales ni tibiales. Este método puede aplicarse en desejes femorales de hasta 20° y tibiales de hasta 30° en el plano coronal. Mediante esta técnica hemos obtenido buenos resultados, a más de 5 años de seguimiento, en 20 de los 22 casos operados.

  20. Uso de la cepa FVB de ratones para la evaluación clínico-experimental de Ketamina (IP) asociada a fenotiacínicos, benzodiacepinas y α2-agonistas

    OpenAIRE

    Molina López, Ana María; Moyano Salvago, M. Rosario; Moreno Barrientos, Sergio; Lora Benítez, Antonio; Barasona García-Arévalo, José A.; Serrano-Caballero, J.M.

    2009-01-01

    El objetivo de este trabajo ha consistido en evaluar el estado fisiológico de los animales mediante el control de las frecuencias respiratoria y cardiaca así como la tasa de saturación de oxígeno durante la anestesia con ketamina asociada a otros fármacos. Para ello hemos utilizado 40 ratones FVB consanguíneos (20 machos y 20 hembras) de 11 semanas de edad, a los que se les administró por vía intraperitoneal ketamina asociada a un depresor del sistema nervioso central: acepr...

  1. Las hormigas (Hymenoptera, Formicidae asociadas a pulgones (Hemiptera, Aphididae en la provincia de Valencia

    Directory of Open Access Journals (Sweden)

    Suay-Cano, V. A.

    2002-06-01

    Full Text Available Twenty-six species of ants associated with aphids, belonging to twelve genera, are collected. Three subfamilies are identified, being the Formicinae the more represented about number of samples, genera and species. On the other hand, Lasius niger has been the species that is found with a more number of aphids (fifty eight species, and it seems to be the ant with a more capacity to establish associations with the different species of aphids. 224 different associations between the ants and the aphids are established and 164 of them are not recorded in the bibliography consulted for Spain.

    Se han recogido veintiséis especies de hormigas asociadas a pulgones, pertenecientes a doce géneros. De las tres subfamilias identificadas, Formicinae ha sido la más representada en cuanto a número de muestras, géneros y especies. Lasius niger, por otra parte, ha sido la especie que se ha encontrado junto a un mayor número de pulgones (cincuenta y ocho especies, demostrando ser la hormiga con mayor capacidad para establecer asociaciones con las diferentes especies de pulgones. Se han establecido un total de 224 asociaciones diferentes entre las hormigas y los áfidos, de las cuales 164 no se han encontrado citadas en la bibliografía consultada para España.

  2. Neumonía asociada al cuidado de la salud

    OpenAIRE

    Adrián Ceccato; Alejandra González; Marcela Heres; Graciela Peluffo; Alfredo Monteverde

    2014-01-01

    La neumonía asociada al cuidado de la salud (NACS) es una entidad diferente a la neumonía adquirida en la comunidad y a la neumonía intrahospitalaria. Existen circunstancias de riesgo para su desarrollo, se describen diferentes formas de presentación, gravedad y patógenos; y hay desacuerdo sobre el tratamiento empírico inicial. El objetivo de este estudio fue analizar la etiología, las características clínicas y la evolución de la NACS en un hospital general. Estudio prospectivo observacional...

  3. Riesgo coronario en la hipertensión arterial sistólica asociada a factores de riesgo prevalentes. Hospital Nacional PNP "Luis N. Saenz"

    OpenAIRE

    2016-01-01

    Estimar el riesgo de padecer una enfermedad coronaria es posible con el uso de herramientas como el score Framingham. La hipertensión arterial sistólica de acuerdo a los lineamientos de las Guías de Práctica Clínica vigentes constituye un punto inicial valido para la investigación de enfermedad coronaria asociada a sus factores de riesgo prevalentes como son diabetes Mellitus, dislipidemia y tabaquismo. El objetivo de esta investigación fue determinar el riesgo coronario en la población con h...

  4. RAS in Pregnancy and Preeclampsia and Eclampsia

    Directory of Open Access Journals (Sweden)

    M. Rodriguez

    2012-01-01

    Full Text Available Preeclampsia is a common disease of pregnancy characterized by the presence of hypertension and commitment of many organs, including the brain, secondary to generalized endothelial dysfunction. Its etiology is not known precisely, but it involved several factors, highlighting the renin angiotensin system (RAS, which would have an important role in the origin of multisystem involvement. This paper reviews the evidence supporting the involvement of RAS in triggering the disease, in addition to the components of this system that would be involved and how it eventually produces brain engagement.

  5. Epidemia de neumonía asociada a ventilación mecánica en Mérida, Yucatán

    Directory of Open Access Journals (Sweden)

    Zaidi Mussaret

    1999-01-01

    Full Text Available OBJETIVO. Determinar las principales características epidemiológicas, clínicas y microbiológicas de una epidemia de neumonía asociada a ventilación mecánica en una unidad de cuidados intensivos en Mérida, Yucatán. MATERIAL Y MÉTODOS. Se diseñó un estudio prospectivo y observacional de 11 meses para determinar incidencia, mortalidad, reservorios potenciales, agentes etiológicos y sus patrones de sensibilidad antimicrobiana. RESULTADOS. La incidencia de neumonía asociada a ventilador fue de 74%. La mortalidad cruda fue de 88%, comparada con una mortalidad esperada de 19.5%. Se aislaron bacterias gramnegativas en 98% de los cultivos, de las cuales 46% fueron sensibles a cefalosporinas de tercera generación, 59% a cefalosporinas de cuarta generación, 70% a ciprofloxacina y 100% a imipenem. Se aislaron Klebsiella pneumoniae y Pseudomonas aeruginosa de algunos circuitos del ventilador y el lavado. CONCLUSIONES. La elevada incidencia de neumonía y la mortalidad asociada en esta unidad de cuidados intensivos se pueden atribuir a la falta de medidas de control de infecciones y a una elevada prevalencia de gérmenes multirresistentes que se relaciona con el uso desmesurado e irracional de antibióticos.

  6. Aspirin for Prevention of Preeclampsia in Lupus Pregnancy

    Directory of Open Access Journals (Sweden)

    Amelie M. Schramm

    2014-01-01

    Full Text Available Preeclampsia, the onset of hypertension and proteinuria during pregnancy, is a common medical disorder with high maternal and fetal mortality and morbidity. The underlying pathology remains poorly understood and includes inflammation, endothelial dysfunction, and an unbalanced thromboxane A2/prostacyclin ratio. For women with systemic lupus erythematosus (SLE, particularly those with preexisting renal disease or with active lupus, the risk of developing preeclampsia is up to 14% higher than it is among healthy individuals. The mechanism is still unknown and the data for preventing preeclampsia in lupus pregnancies are rare. Modulating the impaired thromboxane A2/prostacyclin ratio by administration of low-dose aspirin appears to be the current best option for the prevention of preeclampsia. After providing an overview of the pathogenesis of preeclampsia, preeclampsia in lupus pregnancies, and previous trials for prevention of preeclampsia with aspirin treatment, we recommend low-dose aspirin administration for all lupus patients starting prior to 16 weeks of gestation. Patients with SLE and antiphospholipid syndrome should receive treatment with heparin and low-dose aspirin during pregnancy.

  7. [Serum homocysteine levels in pregnant women with preeclampsia].

    Science.gov (United States)

    Stoĭkova, V; Ivanov, S; Mazneĭkova, V; Tsoncheva, A

    2005-01-01

    Preeclampsia is one of the most common and severe pregnancy complications, which ethiology remains unclear. It is certain that endothelial dysfunction plays a key role in the development of preeclampsia. Homocysteine is an important independent cardiovascular risk factor, which might induce the endothelial dysfunction observed in preeclampsia. 26 pregnant women--14 with preeclampsia (group 1) and 12 healthy term pregnant controls (group 2) were enrolled in the study between December 2003 and August 2004. Six of the women in this group had a superimposed preeclampsia. The mean homocysteine level in the first group was 11,04 mol/l, while in the control group it was 6,24 micromol/l (p homocysteine levels than those with mild form (F = 0.025). Seven of the patients (50%) gave birth before 34th weeks of gestation. The study finds a link between the serum homocysteine as an endothelial dysfunction marker and the development of preeclampsia and a relation between the severity of preeclampsia and the degree of the elevation of the serum homocysteine levels.

  8. Oxidative stress and antioxidant status in fetal circulation in preeclampsia.

    Science.gov (United States)

    Braekke, Kristin; Harsem, Nina K; Staff, Anne C

    2006-11-01

    Preeclampsia is associated with oxidative stress in maternal circulation. The purpose of this study was to explore oxidative stress and antioxidants in the fetal circulation in preeclampsia. Women with preeclampsia (n = 19) or uncomplicated pregnancies (n = 33) delivered by cesarean section were included. Blood was sampled separately from the umbilical vein and artery. 8-Iso-prostaglandin F(2alpha) (8-isoprostane), a stable product of lipid peroxidation, is a reliable marker of oxidative stress. Concentration of total 8-isoprostane in cord plasma was analyzed by gas chromatography-mass spectrometry. Antioxidant status was evaluated measuring ferric reducing ability of plasma and vitamin E. There was no difference between preeclampsia and control groups regarding median plasma concentration of 8-isoprostane in umbilical vein (955 versus 780 pg/mL, p = 0.41) or in umbilical artery (233 versus 276 pg/mL, p = 0.65). Concentration of 8-isoprostane was much higher in plasma from the umbilical vein than artery, suggesting placenta as the source of 8-isoprostane. Median ferric reducing ability of plasma concentration was higher in preeclampsia than in controls, both in the umbilical vein and artery. Median vitamin E concentration in the umbilical vein was higher in preeclampsia, but no difference was found in the umbilical artery. In conclusion, no evidence of increased oxidative stress, evaluated by 8-isoprostane concentration, was found in fetal circulation in preeclampsia.

  9. Potential role of folate in pre-eclampsia.

    Science.gov (United States)

    Singh, Mansi Dass; Thomas, Philip; Owens, Julie; Hague, William; Fenech, Michael

    2015-10-01

    Dietary deficiencies of folate and other B vitamin cofactors involved in one-carbon metabolism, together with genetic polymorphisms in key folate-methionine metabolic pathway enzymes, are associated with increases in circulating plasma homocysteine, reduction in DNA methylation patterns, and genome instability events. All of these biomarkers have also been associated with pre-eclampsia. The aim of this review was to explore the literature and identify potential knowledge gaps in relation to the role of folate at the genomic level in either the etiology or the prevention of pre-eclampsia. A systematic search strategy was designed to identify citations in electronic databases for the following terms: folic acid supplementation AND pre-eclampsia, folic acid supplementation AND genome stability, folate AND genome stability AND pre-eclampsia, folic acid supplementation AND DNA methylation, and folate AND DNA methylation AND pre-eclampsia. Forty-three articles were selected according to predefined selection criteria. The studies included in the present review were not homogeneous, which made pooled analysis of the data very difficult. The present review highlights associations between folate deficiency and certain biomarkers observed in various tissues of women at risk of pre-eclampsia. Further investigation is required to understand the role of folate in either the etiology or the prevention of pre-eclampsia.

  10. Strategy for standardization of preeclampsia research study design.

    Science.gov (United States)

    Myatt, Leslie; Redman, Christopher W; Staff, Anne Cathrine; Hansson, Stefan; Wilson, Melissa L; Laivuori, Hannele; Poston, Lucilla; Roberts, James M

    2014-06-01

    Preeclampsia remains a major problem worldwide for mothers and babies. Despite intensive study, we have not been able to improve the management or early recognition of preeclampsia. At least part of this is because of failure to standardize the approach to studying this complex syndrome. It is possible that within the syndrome there may be different phenotypes with pathogenic pathways that differ between the subtypes. The capacity to recognize and to exploit different subtypes is of obvious importance for prediction, prevention, and treatment. We present a strategy for research to study preeclampsia, which will allow discrimination of such possible subtypes and also allow comparison and perhaps combinations of findings in different studies by standardized data and biosample collection. To make studies relevant to current clinical practice, the definition of preeclampsia can be that currently used and accepted. However, more importantly, sufficient data should be collected to allow other diagnostic criteria to be used and applied retrospectively. To that end, we present what we consider to be the minimum requirements for a data set in a study of preeclampsia that will facilitate comparisons. We also present a comprehensive or optimal data set for in-depth investigation of pathophysiology. As we approach the definition of phenotypes of preeclampsia by clinical and biochemical criteria, adherence to standardized protocols will hasten our understanding of the causes of preeclampsia and development of targeted treatment strategies.

  11. Major changes in diagnosis and management of preeclampsia.

    Science.gov (United States)

    Snydal, Susan

    2014-01-01

    Preeclampsia and eclampsia continue to be major contributors to maternal mortality and morbidity. Lack of appreciation for the multi-organ involvement of preeclampsia, combined with overly rigid criteria for diagnosis, may hinder early diagnosis and appropriate management. Recently, the American College of Obstetricians and Gynecologists Task Force on Hypertension in Pregnancy evaluated the evidence and formulated new recommendations for diagnosis and management. This article reviews some of these recommended changes, including the new classification of the hypertensive diseases of pregnancy. Systolic blood pressure has been shown to be as important as diastolic blood pressure in the diagnosis of preeclampsia. Changes in proteinuria are not predictive of disease severity or maternal or fetal complications; therefore, the magnitude of proteinuria or changes in the amount should not dictate diagnosis or management. Instead, symptoms of cerebral involvement, such as headache and visual changes or signs of end-organ involvement including abnormal laboratory tests (elevated serum creatinine or liver function tests, low platelet count), are evidence of preeclampsia with severe features. Immediate induction of labor is recommended for women with gestational hypertension or preeclampsia at 37 weeks' gestation or later. Pregnant and postpartum women need to know important warning signs and symptoms of preeclampsia. Prompt diagnosis of preeclampsia and appropriate management will improve the quality of care for women.

  12. Copper and Zinc Status in Patients with Preeclampsia in Bangladesh.

    Science.gov (United States)

    Ferdousi, S; Akhtar, S; Begum, S

    2015-10-01

    This study assessed maternal serum copper and zinc levels in preeclampsia to find out the role of trace element disorder in the aetiology of preeclampsia. This cross sectional study was conducted in the dept of Physiology of BSMMU during 2009. Sixty patients of Preeclampsia (BP--140/90 aged 18-39 years, with >20th weeks of pregnancy with proteinuria and edema) participated. Thirty normotensive gravida was control. All subjects were collected from in and out patient department of Obstetric and Gynecology of BSMMU and Dhaka medical college hospital. Serum copper and zinc levels were measured by auto analyzer and atomic absorption sprectrophotometric method respectively. Data were compared between preeclampsia and normotensive pregnant women. Data were expressed as mean and SD and independent sample 't' test and two proportion 'z' test was used for statistical analysis. Mean value of maternal serum zinc (ppreeclampsia. In addition Cu/Zn ratio was significantly higher (preeclampsia. Hypozincemia was found in 13% and hypocupremia was found in 38% of preeclampsia. The result of this study concludes that trace element disorders may be involved in the etiology of preeclampsia.

  13. Enfermedad pulmonar difusa asociada al consumo de tabaco Smoking related interstitial lung disease. Case report

    Directory of Open Access Journals (Sweden)

    JORGE YÁNEZ V

    2008-03-01

    Full Text Available la enfermedad pulmonar difusa asociada al consumo de tabaco no ha sido claramente definida, la bronquiolitis respiratoria (RB es un hallazgo morfológico frecuente en fumadores asintomáticos, se caracteriza por la acumulación de macrófagos pigmentados en los bronquiolos respiratorios. Sólo una pequeña proporción de los sujetos fumadores presenta una respuesta inflamatoria exagerada que compromete el intersticio y espacio alveolar, lo cual corresponde a la bronquiolitis respiratoria asociada a enfermedad pulmonar difusa (RBIID, que se manifiesta por disnea de esfuerzos y tos. la neumonía intersticial descamativa (DIP se caracteriza por compromiso panlobular, fibrosis intersticial discreta e infiltración masiva del espacio aéreo por macrófagos. El patrón histopatológico de RBIID y DIP se pueden sobreponer, siendo los principales elementos diferenciadores entre ambas entidades, la distribución y extensión de las lesiones: compromiso bronquiolo-céntrico en RBIID y difuso en DIP. Se ha planteado que la RB, RBIID y DIP pueden constituir diferentes fases de una misma enfermedad asociada al consumo de tabaco, lo cual aún es motivo de controversia. Con el propósito de ilustrar este problema, se presenta el caso clínico de un paciente fumador que consultó por disnea progresiva, tos e infiltrados pulmonares bilaterales sugerentes de enfermedad pulmonar difusa asociada al tabaquismoThe relationship between cigarette smoke and interstitial lung diseases (ILD is not clear. Respiratory bronchiolitis (RB, usually found as an incidental histologic abnormality in otherwise asymptomatic smokers, is characterized by the accumulation of cytoplasmic golden-brown-pigmented macrophages within respiratory bronchioles. A small proportion of smokers have a more exaggerated response that, in addition to the bronchiole-centered lesions, provokes interstitial and air spaces inflammation and fibrosis extending to the nearby alveoli. This set of histologic

  14. Nefritis tubulo intersticial asociada a parvovirus b19 Tubulointerstitial nephritis associated with parvovirus b19 infection

    Directory of Open Access Journals (Sweden)

    José A. Ramírez

    2005-08-01

    Full Text Available Paciente de 9 años, previamente sana, que ingresa en anasarca con síndrome nefrótico clínico y humoral, asociado a hipertensión arterial y microhematuria, con función renal normal y se comporta como corticorresistente. Se realiza 1° biopsia renal que informa glomerulonefritis proliferativa mesangial difusa con esclerosis focal y segmentaria. En tratamiento con ciclofosfamida y corticoides, presenta síndrome febril prolongado con anemia secundaria a crisis aplásica de la serie roja, asociada con una infección aguda por parvovirus B19, e insuficiencia renal aguda secundaria a nefritis tubulointersticial severa. La PCR para parvovirus B19 DNA fue positiva en tejido renal y médula ósea. La paciente evoluciona a insuficiencia renal crónica terminal. No se puede descartar que desde su inicio, el síndrome nefrótico estuviera asociado al daño glomerular por la infección viral, que comenzó como síndrome nefrótico con componentes nefríticos y que evoluciona inesperadamente a una nefritis tubulointersticial. Este sería el primer caso en el que se documenta como causa de insuficiencia renal crónica terminal, un daño tubulointersticial secundario a parvovirus B19.A previously healthy 9 year old girl developed nephrotic syndrome with hypertension, microhematuria and normal renal function. The patient evolved as steroid resistant nephrotic syndrome whose initial renal biopsy was consistent with diffuse proliferative mesangial glomerulonephritis with focal segmental glomerulosclerosis. At the time of cyclophosphamide and prednisone treatment, she developed a prolonged febrile syndrome. She also had severe anemia following an aplastic crisis induced by human parvovirus B19 infection and acute renal failure secondary to a severe tubulointersticial disease. Bone marrow and renal tissue, tested by polimerase chain reaction were positive for parvovirus, while the patient’s blood was negative. The renal involvement did not improve requiring

  15. Seasonal variation of the onset of preeclampsia and eclampsia

    Directory of Open Access Journals (Sweden)

    Ziba Zahiri

    2007-08-01

    Full Text Available

    BACKGROUND: Preeclampsia is one of the three leading causes of maternal mortality. Studies have suggested that the incidence of preeclampsia may be partially dependent on the month or season of delivery. This study was conducted to evaluate whether seasonal variation has any effect on the incidence of eclampsia or preeclampsia.
    METHODS: From 1999 to 2001, a cross-sectional study in Alzahra Hospital was performed using all deliveries with gestational age more than 20 weeks. Variables of maternal age, parity, occurrence of preeclampsia and eclampsia, and season were evaluated and analyzed by chi-square test in SPSS 10.
    RESULTS: During the period of the study, there were 12,142 deliveries at Alzahra Hospital in Rasht. There were 2,579 (21.3% deliveries in spring, 2,696 (22.2% in summer, 3,645 (30% in autumn, and 3,222 (26.5% in winter. There was no statistically significant relationship between the age, parity and season. Hypertensive disorder was reported in 609 pregnancies (5%, with 11,533 (95% having no hypertensive disorder. Data showed that 397 patients (3.3% had preeclampsia and eclampsia. The highest rate of preeclampsia was in spring (3.6%, and the lowest rate was in summer (3%, but it revealed no statistical difference in the incidence of preeclampsia with season.
    CONCLUSIONS: We found no correlation between preeclampsia or eclampsia and season. It may be due to relative similarities between seasons in North of Iran. For example, there are relative similarities between spring and summer, and between autumn and winter.
    KEY WORDS: Pregnancy-induced hypertension, preeclampsia, eclampsia, seasonal.

  16. Electronegativity and intrinsic disorder of preeclampsia-related proteins.

    Science.gov (United States)

    Polanco, Carlos; Castañón-González, Jorge Alberto; Uversky, Vladimir N; Buhse, Thomas; Samaniego Mendoza, José Lino; Calva, Juan J

    2017-01-01

    Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related proteins was assessed with a supervised technique, a Polarity Index Method (PIM), which evaluates the electronegativity of proteins based solely on their sequence. The commonness of intrinsic disorder was evaluated using several disorder predictors from the PONDR family, the charge-hydropathy plot (CH-plot) and cumulative distribution function (CDF) analyses, and using the MobiDB web-based tool, whereas potential functionality of intrinsic disorder was studied with the D2P2 resource and ANCHOR predictor of disorder-based binding sites, and the STRING tool was used to build the interactivity networks of the preeclampsia-related proteins. Peculiarities of the PIM-derived polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disordered proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. We also showed that many preeclampsia-related proteins contain numerous functional disordered regions. Therefore, these bioinformatics results led us to assume that the preeclampsia proteins are highly associated with the lipoproteins group, and that some preeclampsia-related proteins contain significant amounts of functional disorders.

  17. Prognostic risk factors for early diagnosing of Preeclampsia in Nulliparas

    Directory of Open Access Journals (Sweden)

    Morteza Ghojazadeh

    2013-01-01

    Full Text Available Background: Preeclampsia is of major complications of pregnancy that is associated with maternal morbidity and mortality. Therefore, prediction and early diagnosis of preeclampsia would be helpful for better controlling of related complications. Our study aimed to investigate risk factors helping to predict and early diagnose of preeclampsia. Materials and Methods: A total of 739 nulliparous women at their 24-28 th weeks of the first pregnancy were enrolled in this multi-center cohort study. Incidence or absence of preeclampsia in this population was evaluated up to the end of pregnancy period. For each case, a record sheet was assigned that contained information about haematocrit level in weeks 24-28 th of pregnancy, blood pressure, result of roll-over test in weeks 24-28 th of pregnancy and the presence of disease up to end of the study. Diagnosis of preeclampsia was made based on gold standard. Results : Overall, 3.9 % of all cases developed preeclampsia. The mean maternal age, body mass index (BMI, years of education and positive roll-over test were significantly higher in preeclampsia group (P < 0.001. However, the mean gestational age and changes in the levels of haematocrit were significantly higher in normotensive cases (P < 0.001. Our combined model could predict preeclampsia with a sensitivity of 93% and a specificity of 80%. Conclusion: Simple combined model of demographic characteristics including maternal age, BMI, years of education and positive roll-over tests can predict preeclampsia without any cost for the patients.

  18. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.

    Science.gov (United States)

    Buhimschi, Irina A; Nayeri, Unzila A; Zhao, Guomao; Shook, Lydia L; Pensalfini, Anna; Funai, Edmund F; Bernstein, Ira M; Glabe, Charles G; Buhimschi, Catalin S

    2014-07-16

    Preeclampsia is a pregnancy-specific disorder of unknown etiology and a leading contributor to maternal and perinatal morbidity and mortality worldwide. Because there is no cure other than delivery, preeclampsia is the leading cause of iatrogenic preterm birth. We show that preeclampsia shares pathophysiologic features with recognized protein misfolding disorders. These features include urine congophilia (affinity for the amyloidophilic dye Congo red), affinity for conformational state-dependent antibodies, and dysregulation of prototype proteolytic enzymes involved in amyloid precursor protein (APP) processing. Assessment of global protein misfolding load in pregnancy based on urine congophilia (Congo red dot test) carries diagnostic and prognostic potential for preeclampsia. We used conformational state-dependent antibodies to demonstrate the presence of generic supramolecular assemblies (prefibrillar oligomers and annular protofibrils), which vary in quantitative and qualitative representation with preeclampsia severity. In the first attempt to characterize the preeclampsia misfoldome, we report that the urine congophilic material includes proteoforms of ceruloplasmin, immunoglobulin free light chains, SERPINA1, albumin, interferon-inducible protein 6-16, and Alzheimer's β-amyloid. The human placenta abundantly expresses APP along with prototype APP-processing enzymes, of which the α-secretase ADAM10, the β-secretases BACE1 and BACE2, and the γ-secretase presenilin-1 were all up-regulated in preeclampsia. The presence of β-amyloid aggregates in placentas of women with preeclampsia and fetal growth restriction further supports the notion that this condition should join the growing list of protein conformational disorders. If these aggregates play a pathophysiologic role, our findings may lead to treatment for preeclampsia.

  19. Ethical issues related to screening for preeclampsia.

    Science.gov (United States)

    Jørgensen, Jennifer M; Hedley, Paula L; Gjerris, Mickey; Christiansen, Michael

    2014-09-01

    The implementation of new methods of treating and preventing disease raises many question of both technical and moral character. Currently, many studies focus on developing a screening test for preeclampsia (PE), a disease complicating 2-8% of pregnancies, potentially causing severe consequences for pregnant women and their fetuses. The purpose is to develop a test that can identify pregnancies at high risk for developing PE sufficiently early in pregnancy to allow for prophylaxis. However, the question of implementing a screening test for PE does not only involve an evaluation of technical feasibility and clinical efficacy, it also requires an analysis of how the test influences the conditions and choices for those tested. This study evaluates state-of-the-art techniques for preeclampsia screening in an ethical framework, pointing out the central areas of moral relevance within the context of such screening activity. Furthermore, we propose ethical guidelines that a screening programme for PE should meet in order to become an uncontroversial addition to prenatal health care.

  20. Inventario de la entomofauna asociada al cultivo de pitahaya amarilla (Selenicereus megalanthus Haw.) en Briceño (Boyacá)

    OpenAIRE

    Héctor Iván Patiño-Tiria; Jhon Wilson Martínez-Osorio; Álvaro Enrique Alvarado-Gaona

    2015-01-01

    Boyacá es uno de los departamentos con mayor producción de pitahaya amarilla en el país. Los estudios realizados sobre este cultivo son muy pocos, y el conocimiento de la entomofauna asociada a él es un punto de partida para realizar nuevas investigaciones que permitan identificar la entomofauna asociada a este cultivo en el municipio de Briceño (Boyacá). El desarrollo de esta investigación se llevó a cabo en plantaciones de pitahaya en tres fincas del municipio de Briceño (Boyacá). Se realiz...

  1. Diversidad de levaduras asociadas a chichas tradicionales de Colombia

    Directory of Open Access Journals (Sweden)

    William Andrés López-Arboleda

    2011-01-01

    Full Text Available Título en inglés: Yeast diversity associated to Colombian traditional “chichas” Resumen En Colombia el conocimiento de la comunidad levaduriforme ha sido limitado, ya que los estudios se han enfocado principalmente en especies de interés clínico. Las fermentaciones espontáneas a partir de diversos sustratos representan hábitats de gran importancia para el estudio de la dinámica de las poblaciones de levaduras nativas, por esta razón, en el presente estudio se aislaron e identificaron las levaduras asociadas a las chichas de maíz, piña y arracacha, que son bebidas fermentadas de manera artesanal en Colombia. Se realizó el aislamiento de las levaduras más representativas de la chicha durante sus tres fases de fermentación: inicial, tumultuosa y final. Inicialmente, se hizo una caracterización parcial de los aislados, que incluyó pruebas fisiológicas, y medición de su capacidad para producir filamentos y esporas. Sin embargo, debido a que estas técnicas no fueron suficientes para identificar los aislados hasta el nivel taxonómico de género o de especie, se complementó el estudio de cada aislado empleando técnicas moleculares basadas en el análisis de restricción del gen rRNA 5.8S y los espaciadores transcritos internos (ITS1 e ITS2. Cuando el empleo de esta técnica no permitió obtener resultados definitivos y para confirmar las asignaciones realizadas usando PCR-RFLPs, se secuenció el dominio D1/D2 del gen 26S rRNA de los aislados más representativos. Mediante estas técnicas se lograron identificar las especies más representativas de los tres tipos de chicha: Candida tropicalis, Pichia kluyveri, Pichia guilliermondii, Hanseniapora guilliermondii, Pichia fermentans, Saccharomyces cerevisiae, Candida maltosa, Rhodotorula glutinis, Torulaspora delbrueckii, Hanseniaspora uvarum, Kazachstania exigua, Kluyveromyces marxianus, Yarrowia lypolitica, Candida parapsilosis, Debaromyces hansenii, Cryptococcus arboriformis

  2. A follow-up study of women with a history of severe preeclampsia: relationship between metabolic syndrome and preeclampsia

    Institute of Scientific and Technical Information of China (English)

    LU Jie; ZHAO Yang-yu; QIAO Jie; ZHANG Hong-jun; GE Lin; WEI Yuan

    2011-01-01

    Background Women with a history of preeclampsia have twice the risk of cardiovascular diseases, and there is a graded relationship between the severity of preeclampsia and the risk of cardiac disease. Moreover, metabolic scores are associated with developing preeclampsia. However, since there are no diagnostic criteria for metabolic syndrome during pregnancy and pregnant women undergo metabolic changes, it is difficult to elucidate the relationship between preeclampsia and metabolic syndrome. We carried out a cross-sectional study to investigate the relationship between metabolic syndrome and preeclampsia among women with a history of severe preeclampsia shortly after an indexed pregnancy.Methods We recruited 62 women with a history of severe preeclampsia 1 to 3 years after an indexed pregnancy. Blood pressure and body compositional indices were recorded. Fasting blood samples were tested for glucose, total cholesterol,high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, triglycerides, and insulin. A questionnaire was used to collect demographic data including pre-pregnancy weight and family history of diseases associated with cardiovascular diseases. Criteria for metabolic syndrome were defined by the National Cholesterol Education Program,Adult Treatment Panel Ⅲ 2001 (NCEP Ⅲ) and International Diabetes Federation 2005 (IDF). Data were analyzed by the α2 test and multivariate Logistic regression.Results According to NCEP Ⅲ and IDF standards, 17 (27%) and 24 (39%) women, respectively, were identified as having metabolic syndrome. Being overweight pre-pregnancy and currently overweight were risk factors, and currently overweight was an independent risk factor. A combination of blood pressure and waist circumference was predictive of metabolic syndrome with a sensitivity of 91.67% and specificity of 94.74%.Conclusions An unfavorable metabolic constitution in women may lead to metabolic syndrome, preeclampsia, and long-term cardiovascular

  3. Infección por chikunguña materno-fetal asociada con miocarditis neonatal

    OpenAIRE

    Corrales Martínez, Silvia Catalina; Facultad de Salud, Universidad Surcolombiana-Hospital Universitario Hernando Moncaliano, Neiva, Colombia.; Fonseca, Carlos; Unidad de Cuidado Intensivo Neonatal-Hospital Universitario Hernando Moncaliano, Neiva, Colombia; Salgado, Doris; Departamento Infectología Pediátrica, Facultad de Salud, Universidad Surcolombiana-Hospital Universitario Hernando Moncaliano, Neiva, Colombia.

    2016-01-01

     El virus de chikunguña es un arbovirus de la familia Togaviridae y fue aislado por primera vez en Tanzania y Uganda, en 1953. Esta infección se ha desarrollado de manera endémica y es transmitida por el mosquito del género Aedes. El mecanismo exacto de la transmisión de madre a hijo aún no se tiene claro, pero se han identificado potenciales complicaciones de la transmisión vertical, como malformaciones congénitas, mortinatos, restricción del crecimiento intrauterino y partos pretérmino. En ...

  4. Escritura en niños con dificultades en lectura: ¿habilidades asociadas o disociadas?

    OpenAIRE

    Cartagena Vélez, Paula Gisela; Muñetón Ayala, Mercedes Amparo

    2016-01-01

    El presente artículo es producto de una investigación cuyo objetivo principal fue identificar las relaciones entre los procesos de lectura y escritura. Para ello, se realizó un estudio en la ciudad de Medellín (Colombia), donde se examinó si los niños y las niñas (8 – 10 años) que presentaban dificultades de lectura (CDL) también mostraban dificultades en escritura a pesar de aportarles input visual y auditivo. Una psicóloga clínica, como criterio experto, evaluó el rendimiento de escritura e...

  5. Escritura en niños con dificultades en lectura: ¿habilidades asociadas o disociadas?

    Directory of Open Access Journals (Sweden)

    Cartagena Vélez, Paula Gisela

    2016-01-01

    Full Text Available El presente artículo es producto de una investigación cuyo objetivo principal fue identificar las relaciones entre los procesos de lectura y escritura. Para ello, se realizó un estudio en la ciudad de Medellín (Colombia, donde se examinó si los niños y las niñas (8 – 10 años que presentaban dificultades de lectura (CDL también mostraban dificultades en escritura a pesar de aportarles input visual y auditivo. Una psicóloga clínica, como criterio experto, evaluó el rendimiento de escritura en 11 participantes sin dificultades de lectura (SDL y 12 CDL. Se analizaron diferentes tipos de errores como los de sustitución, omisión, rotación, adición, inversión, fragmentación y cambios consonánticos. Así mismo se tuvo en cuenta la latencia de la respuesta. Los resultados mostraron que el grupo CDL presenta latencias de las respuestas más altas que el grupo SDL. Asimismo, el grupo CDL invierte más tiempo en la escritura de las palabras y cometen más errores. En este sentido, los resultados apoyan la asociación de ambos procesos.

  6. Cardiovascular and thrombogenic risk of decidual vasculopathy in preeclampsia.

    NARCIS (Netherlands)

    Stevens, D.U.; Al-Nasiry, S.; Fajta, M.M.; Bulten, J.; Dijk, A.P.J. van; Vlugt, M.J. van der; Oyen, W.J.G.; Vugt, J.M.G. van; Spaanderman, M.E.A.

    2014-01-01

    OBJECTIVE: Women with a history of preeclampsia (PE) have an increased prevalence of cardiometabolic, cardiovascular, and prothrombotic risk factors. Remotely, these women are at increased risk of developing cardiovascular and thrombotic disease. Decidual vasculopathy (DV) describes vascular lesions

  7. Metabolic syndrome as a risk factor for hypertension after preeclampsia

    NARCIS (Netherlands)

    Spaan, J.J.; Sep, S.J.; Balen, V.L. van; Spaanderman, M.E.A.; Peeters, L.L.

    2012-01-01

    OBJECTIVE: To identify metabolic and obstetric risk factors associated with hypertension after preeclampsia. METHODS: We analyzed demographic and clinical data from a postpartum screening (blood pressure, microalbuminuria and fasting plasma levels of glucose, insulin, and lipid profile) from 683 pri

  8. Loss of Thrombomodulin in Placental Dysfunction in Preeclampsia

    NARCIS (Netherlands)

    Turner, Rosanne J; Bloemenkamp, Kitty W M; Bruijn, Jan A; Baelde, Hans J

    2016-01-01

    OBJECTIVE: Preeclampsia is a pregnancy-specific syndrome characterized by placental dysfunction and an angiogenic imbalance. Systemically, levels of thrombomodulin, an endothelium- and syncytiotrophoblast-bound protein that regulates coagulation, inflammation, apoptosis, and tissue remodeling, are i

  9. Gene expression profiling of placentas affected by pre-eclampsia

    DEFF Research Database (Denmark)

    Hoegh, Anne Mette; Borup, Rehannah; Nielsen, Finn Cilius;

    2010-01-01

    Several studies point to the placenta as the primary cause of pre-eclampsia. Our objective was to identify placental genes that may contribute to the development of pre-eclampsia. RNA was purified from tissue biopsies from eleven pre-eclamptic placentas and eighteen normal controls. Messenger RNA...... expression from pooled samples was analysed by microarrays. Verification of the expression of selected genes was performed using real-time PCR. A surprisingly low number of genes (21 out of 15,000) were identified as differentially expressed. Among these were genes not previously associated with pre-eclampsia...... as bradykinin B1 receptor and a 14-3-3 protein, but also genes that have already been connected with pre-eclampsia, for example, inhibin beta A subunit and leptin. A low number of genes were repeatedly identified as differentially expressed, because they may represent the endpoint of a cascade of events...

  10. New diagnosis myasthenia gravis and preeclampsia in late pregnancy.

    Science.gov (United States)

    Ozcan, John; Balson, Ian Frank; Dennis, Alicia T

    2015-02-26

    Myasthenia gravis is a chronic autoimmune disease of neuromuscular transmission resulting in fatigable skeletal muscle weakness. Preeclampsia is a multisystem disease of pregnancy which is characterised by hypertension and involvement of one or more organ systems. Both diseases are responsible for considerable morbidity and mortality for mother and fetus. The occurrence of both preeclampsia and myasthenia gravis in pregnancy is very rare, and conflicts arise when considering the optimal management of each disease.We present a case of a parturient who was newly diagnosed with both myasthenia gravis and preeclampsia in late pregnancy. Myasthenia treatment was started with prednisolone and pyridostigmine, and delivery was by caesarean section at 37 weeks gestation under spinal anaesthesia. Postnatally, the patient developed worsening of myasthenia and preeclampsia symptoms. We consider the anaesthetic implications for both diseases and describe our approach for the management of this case.

  11. What's new in obstetric anesthesia? Focus on preeclampsia.

    Science.gov (United States)

    Leffert, L R

    2015-08-01

    Recent advances in the diagnosis, pathogenesis, and understanding of preeclampsia-related morbidity provide opportunities to optimize clinical management of the mother and fetus. These discoveries are timely, as contemporary data suggest that the prevalence of preeclampsia, affecting 7.5% of pregnancies globally and 2-5% in the USA, has increased by up to 30% over the last decade. Managing pregnant patients with preeclampsia can be challenging for all members of the obstetric care team due to the disease's multi-organ system maternal and fetal effects. This review presents recent updates in the definition of preeclampsia, etiology, comorbidities and therapeutic interventions and discusses how they impact the care of these high-risk patients.

  12. Assessment of maternal cerebral blood flow in patients with preeclampsia

    Directory of Open Access Journals (Sweden)

    Mandić Vesna

    2005-01-01

    Full Text Available Introduction Systemic vasoconstrktion in preeclamptic patients increases vascular resistance, and is manifested by increased arterial blood flow velocity. The aim of the study is to evaluate if there is a change of Doppler indices in maternal medial cerbral artery (MCA in severe preeclampsia due to: 1 severity of clinical symptoms, 2 the beginning of eclamptic attack and 3 the application of anticonvidsive therapy. Material and methods A prospective clinical study included 92 pregnant women, gestational age 28-36 weeks. They were divided into three groups: normotensive (n=30, mild preeclampsia (n=33, and severe preeclampsia (n=29. We investigated maternal cerebral circulation by assessing the MCA. We registrated: pulsatility index (Pi, resistance index (Ri, Systolic/diastolic ratio (S/D, and the maximum systolic, end diastolic and medium velocity. Patients with severe preeclampsia were divided into two subgroups: subgroup 1 included patients without symptoms of threatening eclampsia (n=18; 62.06%; while subgroup 2 included those with symptoms of preeclampsia (n=11; 37.94%. All patients with severe preeclampsia were treated with magnesium sulfate (MgSO4, and cerebral blood flow was measured before and after the treatment. Statistical analysis was done by oneway ANOVA, Student t-test and t-paired sample test. The difference was considered to be significant if p < 0.05. Results Significantly increased Pi, Ri and all velocities were established in the group of patients with severe preeclampsia compared with the other two groups. In the group with severe preeclamsia we registrated significantly increased values of all velocities (patients with signs of threatening eclampsia. After MgSO4 treatment in patients with severe preeclampsia significantly decreased values of Pi, Ri, S/D ratio and all velocities were registered. Discussion In the studied group of patients with severe preclampsia we found increased velocity values, Pi and Ri, especially in

  13. Platelet count and platelet indices in women with preeclampsia

    Directory of Open Access Journals (Sweden)

    AlSheeha MA

    2016-11-01

    Full Text Available Muneera A AlSheeha,1 Rafi S Alaboudi,1 Mohammad A Alghasham,1 Javed Iqbal,2 Ishag Adam1 1Department of Obstetrics and Gynaecology, College of Medicine, Qassim University, Buriadah, 2Department of Obstetrics and Gynecology, Maternity and Children’s Hospital, Qassim, Kingdom of Saudi Arabia Background: Although the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia.Objective: To compare platelet indices, namely platelet count (PC, mean platelet volume (MPV, platelet distribution width (PDW, and PC to MPV ratio in women with preeclampsia compared with healthy controls.Setting: Qassim Hospital, Kingdom of Saudi Arabia.Design: A case–control study. Sixty preeclamptic women were the cases and an equal number of healthy pregnant women were the controls.Results: There was no significant difference in age, parity, and body mass index between the study groups. Sixteen and 44 of the cases were severe and mild preeclampsia, respectively. There was no significant difference in PDW and MPV between the preeclamptic and control women. Both PC and PC to MPV ratios were significantly lower in the women with preeclampsia compared with the controls. There was no significant difference in the PC, PDW, MPV, and PC to MPV ratio when women with mild and severe preeclampsia were compared. Using receiver operating characteristic (ROC curves, the PC cutoff was 248.0×103/µL for diagnosis of preeclampsia (P=0.019; the area under the ROC curve was 62.4%. Binary regression suggests that women with PC <248.010×103/µL were at higher risk of preeclampsia (odds ratio =2.2, 95% confidence interval =1.08–4.6, P=0.03. The PC/MPV cutoff was 31.2 for diagnosis of preeclampsia (P=0.035, the area under the ROC curve was 62.2%.Conclusion: PC <248.010×103/µL and PC to MPV ratio 31.2 are valid predictors of preeclampsia. Keywords: preeclampsia, platelets, PDW, mean platelet

  14. The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia

    Directory of Open Access Journals (Sweden)

    Norikazu Ueki

    2015-01-01

    Full Text Available Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5–8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called “a disease of theories.” The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analyze the molecular mechanisms of preeclampsia with a particular focus on the pathogenesis of the hypertension in preeclampsia and its association with the renin-angiotensin system. In addition, we propose potential alternative strategies to target the renin-angiotensin system, which is enhanced during pregnancy.

  15. EVALUATION OF THYROID FUNCTION IN PRE-ECLAMPSIA

    Directory of Open Access Journals (Sweden)

    Sunanda

    2016-03-01

    Full Text Available Hypertensive disorders of pregnancy complicate about 5-10% of all pregnancies. According to world health organisation (WHO nearly one tenth of all maternal deaths are associated with hypertensive disorders of pregnancy in Asia. The majority of deaths due to preeclampsia and eclampsia are avoidable through the provision of timely and effective care to the women presenting with these complications. Optimizing health care to prevent and treat women with hypertensive disorders is a necessary step towards achieving the Millennium Development Goals. AIMS AND OBJECTIVES The present study is aimed to evaluate thyroid function in pre-eclampsia and to compare maternal and foetal outcome in cases of pre-eclampsia with and without hypothyroidism. METHODS The study was conducted at Gandhi Hospital, Secunderabad from September 2010 to September 2012. A observational study was conducted. Hundred pregnant women meeting the criteria of preeclampsia and eclampsia presenting to antenatal ward, delivery room and high risk unit in the third trimester were selected and compared to hundred normotensive pregnant women in the third trimester. RESULTS In the present study, thyroid stimulating hormone levels were raised in 38 % of pre-eclampsia cases compared to 14% of normotensive cases (P value 3 mIU/L had more complications compared to pre-eclamptic patients with TSH < 3 mIU/L. CONCLUSION Pre-eclampsia is associated with hypothyroidism. Pre-eclamptic patients with raised thyroid stimulating hormone levels had poor maternal and foetal outcome compared to those with normal levels. Thyroid Function tests must be done in all pre-eclampsia cases. Therefore, identification of thyroid abnormalities and appropriate measures might affect the occurrence and severity of the morbidity and mortality associated with pre-eclampsia.

  16. Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria

    OpenAIRE

    2013-01-01

    Gilles Guerrier,1 Bukola Oluyide,2 Maria Keramarou,1 Rebecca Grais11Epicentre, Paris, France; 2Médecins Sans Frontières, Paris, FranceObjective: To explore traditional herbal medicines as potential risk factors of severe preeclampsia and eclampsia in Nigeria.Methods: We conducted a retrospective case-control study from October 2010 to May 2011. The cases were all pregnant women admitted to the Jahun Hospital during the study period with severe preeclampsia or eclampsia a...

  17. VEGF Deficit is Involved in Endothelium Dysfunction in Preeclampsia

    Institute of Scientific and Technical Information of China (English)

    周琼; 刘海意; 乔福元; 吴媛媛; 徐京晶

    2010-01-01

    This study examined the association of expression of vascular endothelial growth factor(VEGF),a promoter of angiogenesis,with endothelium dysfunction in preeclampsia.The level of VEGF protein and mRNA in the placenta and peripheral blood samples of 30 preeclampsia patients and 30 normotensive pregnant women was measured by immunohistochemistry,real-time reverse transcriptase-polymerase chain reaction(RT-PCR) and enzyme-linked immunosorbent assay(ELISA),respectively.VEGF expression in the human umbilical vei...

  18. Contemporary Clinical Management of the Cerebral Complications of Preeclampsia

    OpenAIRE

    Kane, Stefan C.; Alicia Dennis; Fabricio da Silva Costa; Louise Kornman; Shaun Brennecke

    2013-01-01

    The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality arising from these conditions, for women and their infants alike. This paper outlines the evidence base for contemporary management principles pertaining to the neurological sequelae of preeclampsia, primarily from the maternal perspective, but with consideration of fetal and neonatal aspects as well. It concludes with a discussion regarding future directions in t...

  19. Proteinuria as a predictor of complications of pre-eclampsia

    Directory of Open Access Journals (Sweden)

    Belfort Michael

    2009-03-01

    Full Text Available Abstract Proteinuria is a defining criterion for the diagnosis of pre-eclampsia. The amount of protein lost per day has been thought by some to predict both maternal and fetal outcome. The systematic review of 16 primary papers including over 6700 patients by Thangaratinam and colleagues published this month in BMC Medicine suggests otherwise. This finding may influence our management of pre-eclampsia.

  20. Contemporary Clinical Management of the Cerebral Complications of Preeclampsia

    Directory of Open Access Journals (Sweden)

    Stefan C. Kane

    2013-01-01

    Full Text Available The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality arising from these conditions, for women and their infants alike. This paper outlines the evidence base for contemporary management principles pertaining to the neurological sequelae of preeclampsia, primarily from the maternal perspective, but with consideration of fetal and neonatal aspects as well. It concludes with a discussion regarding future directions in the management of this potentially lethal condition.

  1. Platelet count and platelet indices in women with preeclampsia

    OpenAIRE

    AlSheeha MA; Alaboudi RS; Alghasham MA; Iqbal J; Adam I

    2016-01-01

    Muneera A AlSheeha,1 Rafi S Alaboudi,1 Mohammad A Alghasham,1 Javed Iqbal,2 Ishag Adam1 1Department of Obstetrics and Gynaecology, College of Medicine, Qassim University, Buriadah, 2Department of Obstetrics and Gynecology, Maternity and Children’s Hospital, Qassim, Kingdom of Saudi Arabia Background: Although the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia.Obj...

  2. Asymmetric dimethylarginine in the maternal and fetal circulation in preeclampsia.

    Science.gov (United States)

    Braekke, Kristin; Ueland, Per M; Harsem, Nina K; Staff, Anne Cathrine

    2009-10-01

    Preeclampsia is a leading cause of intrauterine growth restriction and preterm birth. Endothelial dysfunction is the common final pathway leading to clinical signs of preeclampsia including hypertension and proteinuria. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS and induces endothelial dysfunction by reversibly inhibiting NO production from l-arginine. The purpose of this study was to investigate maternal and fetal concentrations of ADMA, l-arginine, and symmetric dimethylarginine (SDMA). Women with preeclampsia (n = 47) and controls (n = 51) who gave birth by cesarean section were included in the study. We analyzed the maternal plasma and umbilical vein and artery plasma. We found that not only maternal concentrations of ADMA and SDMA but also l-arginine were significantly higher in women with preeclampsia than in controls. In fetal samples, only SDMA concentrations were higher in the preeclampsia group than in controls. The median ADMA concentration was three times higher in the fetal circulation than in the maternal circulation, but there was no difference between the preeclampsia group and the control group, and the veno-arterious gradient indicated that the placenta was the source of ADMA.

  3. Galectin signature in normal pregnancy and preeclampsia.

    Science.gov (United States)

    Blois, Sandra M; Barrientos, Gabriela

    2014-03-01

    Members of the galectin family are expressed within the female reproductive tract and have been shown to be involved in multiple biological functions that support the progression of pregnancy. Specific expression patterns of different members of this family have been identified at the maternal decidua and on the placental side. In some cases, mechanisms by which galectins exert their functions have been delineated in adverse pregnancy outcomes. This review summarizes studies on galectins that have been documented to be important for pregnancy maintenance, either supporting the maternal adaptation to pregnancy or the placentation process. In addition, we focus our discussion on the role of galectins in preeclampsia, a specific life-threatening pregnancy disorder.

  4. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury.

    Science.gov (United States)

    Pruthi, Dafina; Khankin, Eliyahu V; Blanton, Robert M; Aronovitz, Mark; Burke, Suzanne D; McCurley, Amy; Karumanchi, S Ananth; Jaffe, Iris Z

    2015-04-01

    Cardiovascular disease (CVD) remains the leading killer of women in developed nations. One sex-specific risk factor is preeclampsia, a syndrome of hypertension and proteinuria that complicates 5% of pregnancies. Although preeclampsia resolves after delivery, exposed women are at increased long-term risk of premature CVD and mortality. Pre-existing CVD risk factors are associated with increased risk of developing preeclampsia but whether preeclampsia merely uncovers risk or contributes directly to future CVD remains a critical unanswered question. A mouse preeclampsia model was used to test the hypothesis that preeclampsia causes an enhanced vascular response to future vessel injury. A preeclampsia-like state was induced in pregnant CD1 mice by overexpressing soluble fms-like tyrosine kinase-1, a circulating antiangiogenic protein that induces hypertension and glomerular disease resembling human preeclampsia. Two months postpartum, soluble fms-like tyrosine kinase-1 levels and blood pressure normalized and cardiac size and function by echocardiography and renal histology were indistinguishable in preeclampsia-exposed compared with control mice. Mice were then challenged with unilateral carotid injury. Preeclampsia-exposed mice had significantly enhanced vascular remodeling with increased vascular smooth muscle cell proliferation (180% increase; Ppreeclampsia. These data support a new model in which vessels exposed to preeclampsia retain a persistently enhanced vascular response to injury despite resolution of preeclampsia after delivery. This new paradigm may contribute to the substantially increased risk of CVD in woman exposed to preeclampsia.

  5. LOS NIVELES SÉRICOS DE ADENOSIN DEAMINASA Y ÁCIDO ÚRICO SE CORRELACIONAN EN PACIENTES GESTANTES CON TRASTORNOS HIPERTENSIVOS

    OpenAIRE

    2009-01-01

    Objetivo: Evaluar los niveles séricos de la enzima adenosin-deaminasa (ADA) en pacientes gestantes normales y en pacientes con trastornos hipertensivos del embarazo, para determinar su relación con la gravedad del trastorno hipertensivo y con los niveles séricos de marcadores bioquímicos. Método: Se evaluaron pacientes con preeclampsia leve, preeclampsia grave, hipertensión gestacional y embarazadas sanas (n=10 por cada grupo). Se determinaron los niveles de ADA, ácido úrico, creatinina, amon...

  6. Estudio de variables asociadas a la psicoterapia grupal en los procesos de duelo patológico.

    OpenAIRE

    Juan Díaz Curiel

    2011-01-01

    Se estudian variables asociadas al proceso terapéutico grupal (10 sesiones de 75 minutos) de 24 sujetos adultos (23 mujeres y 1 varón) distribuídos en cuatro grupos de terapia durante los años 2007-2010 con diagnóstico de duelo complicado (DC). El DC se evalúa a través de la Escala de Prigerson (punto de corte más de 24) (Prigerson, 1995, Traducción Española Olmeda y García, 2006). Los pacientes pertenecen al Equipo de Salud (ESM) de Vallecas Villa y acuden remitidos por el médico de Atención...

  7. What Are the Risks of Preeclampsia and Eclampsia to the Mother?

    Science.gov (United States)

    ... Resources and Publications What are the risks of preeclampsia & eclampsia to the mother? Skip sharing on social ... links Share this: Page Content Risks During Pregnancy Preeclampsia during pregnancy is mild in 75% of cases. ...

  8. What Are the Risks of Preeclampsia and Eclampsia to the Fetus?

    Science.gov (United States)

    ... Resources and Publications What are the risks of preeclampsia & eclampsia to the fetus? Skip sharing on social media links Share this: Page Content Preeclampsia affects the flow of blood to the placenta. ...

  9. A prospective study of trans fat intake and risk of preeclampsia in Denmark

    DEFF Research Database (Denmark)

    Chavarro, J. E.; Halldorsson, T. I.; Leth, Torben;

    2011-01-01

    Association of intake of trans fatty acids in the 2nd trimester of pregnancy with risk of preeclampsia was studied by following 67 186 pregnancies of women participating in the Danish National Birth Cohort between 1998 and 2003. Diet was assessed with a food frequency questionnaire at gestation wk...... 25; preeclampsia diagnosis was obtained by linkage with the Danish National Patient Registry. 1804 cases of preeclampsia and 402 cases of severe preeclampsia were identified in the cohort. Intake of trans fats decreased during the study period as a consequence of reduction in industrial trans fat...... intake. Intake of trans fats in the 2nd trimester was unrelated to risk of preeclampsia or severe preeclampsia. Relative risk (95% confidence interval; P, trend) of preeclampsia and severe preeclampsia comparing top to bottom quintiles of trans fat intake were 0.95 (0.81; 1.11, 0.33) and 1.07 (0.78; 1...

  10. Amiloidosis renal en paciente con osteomielitis de extremidad inferior

    Directory of Open Access Journals (Sweden)

    María Vicente Santos

    2012-09-01

    Full Text Available La amiloidosis secundaria (AA sistémica es una entidad frecuente, asociada con enfermedades inflamatorias e infecciones de larga evolución, así como con algunas neoplasias. Presentamos el caso de un varón de 58 años, con antecedente de úlcera en miembro inferior derecho de más de 30 años de evolución y con síndrome nefrótico secundario a amiloidosis AA.

  11. The Relationship between Preeclampsia and Quadruple Screening Test in Nuliparous

    Directory of Open Access Journals (Sweden)

    Farnaz Zand Vakili

    2017-01-01

    Full Text Available Introduction: Early diagnosis and prediction of preeclampsia needs appropriate obstetric care. Preeclampsia predicting methods are important. This study was designed to determine the correlation between preeclampsia and quadruple screening test in the nulliparous. Materials and Methods:  This case - control study was conducted on 54 pregnant women with preeclampsia (case group and 108 healthy pregnant women (control group who referred to health centers in Sanandaj, Iran. Ultrasonography was performed to determine the gestational age by a radiologist. Maternal serum levels of alpha fetoprotein (AFP, human chorionic gonadotropin (hCG, unconjugated estriol (uE3, and inhibin-A were measured in the second trimester of pregnancy. Data were analyzed using SPSS statistical software and Chi-square test, T-test, sensitivity, specificity, positive and negative predictive values. Results: The results showed that the sensitivity and specificity for the diagnosis of preeclampsia in pregnant women for hCG were 35.2% and 79.6 respectively. These findings for estriol were 20.4% and 88.9%, for inhibin-A were 38.8% and 88% and for alpha fetoprotein were 38.8% and 74.1%. The positive predictive value for hCG, estriol, inhibin-A and alpha fetoprotein were 46.3%, 47.8%, 61.8% and 42.9% respectively. The negative predictive value for hCG, estriol, inhibin-A and alpha fetoprotein were also 71%, 69.1%, 74.2% and 70.8% respectively. Conclusion: There was a relationship between preeclampsia and high levels of inhibin-A and hCG. Further studies on these markers and evaluating their usefulness in the diagnosis and management of preeclampsia are recommended.

  12. Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria

    Directory of Open Access Journals (Sweden)

    Guerrier G

    2013-08-01

    Full Text Available Gilles Guerrier,1 Bukola Oluyide,2 Maria Keramarou,1 Rebecca Grais11Epicentre, Paris, France; 2Médecins Sans Frontières, Paris, FranceObjective: To explore traditional herbal medicines as potential risk factors of severe preeclampsia and eclampsia in Nigeria.Methods: We conducted a retrospective case-control study from October 2010 to May 2011. The cases were all pregnant women admitted to the Jahun Hospital during the study period with severe preeclampsia or eclampsia and women presenting with normal pregnancy after 22 weeks.Results: During the study period, a total of 1,257 women (44% were recorded as having normal pregnancy, and 419 (16% women had severe preeclampsia/eclampsia (175 with severe preeclampsia and 244 with eclampsia. The risk factors found to be associated with a greater risk of severe preeclampsia/eclampsia included personal history of preeclampsia (odds ratio [OR] = 21.5; P < 0.001, personal history of preexisting hypertension (OR = 10.5; P < 0.001, primiparity (OR = 2.5; P = 0.001, occupation as housewife (OR = 1.9; P = 0.008, and fewer than four antenatal care visits (OR = 1.6; P = 0.02. Use of traditional treatments during pregnancy was associated with a higher risk of developing severe preeclampsia/eclampsia (OR = 1.6 95%; confidence interval [CI]: 1.2-2.1 by univariate analysis only.Conclusion: Use of traditional treatment, which increases delays before consulting the official health sector, might be a marker for harmful behavior. Community-based studies could provide additional information on the practice of herbal therapy in this population.Keywords: hypertensive disorders, pregnancy, traditional treatments, herbal use

  13. Vasculitis asociadas a anticuerpos anti-citoplasma de neutrófilos: Clínica y tratamiento

    Directory of Open Access Journals (Sweden)

    María Virginia Paolini

    2013-04-01

    Full Text Available Las vasculitis asociadas a anticuerpos anti-citoplasma de neutrófilos (ANCA comprenden a un grupo de enfermedades caracterizadas por la inflamación de la pared de pequeños vasos. Analizamos las características epidemiológicas y clínicas en una serie de 47 pacientes: 23 (49% granulomatosis de Wegener (GW, 15 (32% poliangeítis microscópica (PAM y nueve (19% vasculitis limitada al riñón (VLR. La edad media al inicio de los síntomas fue de 50.7 ± 14.9 años. La manifestación clínica más frecuente fue el compromiso renal en 41 (87% pacientes, seguido por el pulmonar en 26 (55% y el otorrinolaringológico en 17 (36%. En 26 (55% se asoció compromiso renal y pulmonar. La forma clínica más frecuente fue la generalizada en 23 (49%, seguida por la grave en 18 (38%. El 89% presentaron determinaciones de ANCA positivas. Cuatro (8% no recibieron tratamiento inmunosupresor de inicio. De los 43 que recibieron tratamiento de inicio, 29 (67% tuvieron remisión completa, con un tiempo de remisión promedio de 35.3 meses. Once (26% presentaron recaídas, diez (91% recaídas mayores y uno (9% menor. Doce (28% fallecieron, siete en forma temprana y cinco durante la evolución de la enfermedad. Quince (31% evolucionaron a insuficiencia renal crónica. Los 26 pacientes en seguimiento tuvieron respuesta al tratamiento y 20 (77% de ellos estaban en remisión al finalizar el estudio. Las vasculitis asociadas a ANCA continúan siendo enfermedades de alta morbilidad y mortalidad, a pesar de las mejorías logradas con los tratamientos inmunosupresores.

  14. Pre-eclampsia Diagnosis and Treatment Options : A Review of Published Economic Assessments

    NARCIS (Netherlands)

    Zakiyah, Neily; Postma, Maarten J.; Baker, Philip N.; van Asselt, Antoinette D. I.

    2015-01-01

    Pre-eclampsia is a pregnancy complication affecting both mother and fetus. Although there is no proven effective method to prevent pre-eclampsia, early identification of women at risk of pre-eclampsia could enhance appropriate application of antenatal care, management and treatment. Very little is k

  15. Maternal Preeclampsia and Androgens in the Offspring around Puberty: A Follow-Up Study

    Science.gov (United States)

    Janszky, Imre; Åsvold, Bjørn O.; Økland, Inger; Forman, Michele R.; Vatten, Lars J.

    2016-01-01

    Background Children born after preeclampsia may have a dominant androgen profile in puberty compared with other children. Circulating androgen concentrations at 11–12 years of age were compared between offspring born after preeclampsia, and children whose mothers did not have preeclampsia. Methods A total of 611 mother-offspring pairs were followed up 11 (daughters) or 12 (sons) years after birth: 218 pairs in the preeclampsia group, and 383 pairs without preeclampsia. Circulating total testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor I (IGF-I) were measured in the children. In boys, testicular volume was also measured. Results Among girls born after preeclampsia, DHEAS concentrations were higher than in unexposed girls (ppreeclampsia with severe features had the lowest DHEAS levels. In contrast, testosterone concentrations were highest in girls born after preeclampsia with severe features, both compared to other girls in the preeclampsia group, and compared to unexposed girls (ppreeclampsia group compared with unexposed boys (ppreeclampsia with severe features had the lowest concentrations of DHEAS. Compared with unexposed boys, testicular volume (p = 0.015) and IGF-I (p = 0.004) were higher for boys in the preeclampsia group, except for boys in the clinically severe preeclampsia group. Conclusions In utero exposure to preeclampsia is associated with androgen hormonal patterns in early puberty that depend on clinical severity of preeclampsia and sex of the offspring. The hormonal differences may reflect different timing of pubertal development, and may have consequences for future health of the offspring. PMID:27992610

  16. Association of vitamin D deficiency during pregnancy with preeclampsia and eclampsia

    Directory of Open Access Journals (Sweden)

    Poonam Goel

    2016-09-01

    Conclusions: Although mean serum 25(OHD levels were significantly less in preeclampsia/eclampsia group, prevelance of vitamin D deficiency was not significantly different in pregnant women with preeclampsia/eclampsia as compared to women who did not have preeclampsia/eclampsia. [Int J Reprod Contracept Obstet Gynecol 2016; 5(9.000: 3046-3050

  17. An analysis of the differences between early and late preeclampsia with severe hypertension.

    Science.gov (United States)

    Li, X L; Guo, P L; Xue, Y; Gou, W L; Tong, M; Chen, Q

    2016-01-01

    Preeclampsia is clinically divided into early onset and late onset preeclampsia based on the gestational age at delivery. Although the diagnostic criteria are the same in each subgroup of preeclampsia, it has been suggested that the maternal and perinatal mortalities of early onset and late onset preeclampsia are different. However, studies that compare clinical parameters or laboratory biomarkers between early onset and late onset preeclampsia are limited. Data on 177 women with early or late preeclampsia with severe hypertension were collected from a University Teaching Hospital from January 2010 to January 2011 and analysed. Data included all the clinical parameters and laboratory biomarkers of liver and renal function. 63 women and 114 women were diagnosed with early and late preeclampsia with severe hypertension, respectively. There was no difference in the maternal age and the incidence of clinical symptoms including edema, vision disturbance, severe headache and stillbirth between two groups. There was a decrease in alkaline phosphatase levels in early preeclampsia with severe hypertension but other markers of liver function were not altered. However, renal function including blood urea nitrogen, creatinine and uric acid were significantly higher in early preeclampsia with severe hypertension. Umbilical artery systolic velocity/diastolic velocity ratio was significantly higher in early preeclampsia with severe hypertension. Our data demonstrates that the laboratory biomarkers of renal function differ between early and late preeclampsia with severe hypertension. The severity of renal dysfunction correlated with the time of delivery in preeclampsia with severe hypertension.

  18. Chronic hypertension superimposed on preeclampsia at 13 gestational weeks: a case report with review

    Institute of Scientific and Technical Information of China (English)

    ZHU Yu-chun; SUN Yu; YANG Hui-xia

    2012-01-01

    Preeclampsia is represented by hypertension and proteinuria in pregnancy.It usually occurs after 20 gestational weeks.There are few reports on preeclampsia before 20 gestational weeks.In this case,we report a patient with chronic hypertension superimposed with preeclampsia at 13 gestational weeks.

  19. Serum uric acid may not be involved in the development of preeclampsia.

    Science.gov (United States)

    Chen, Q; Lau, S; Tong, M; Wei, J; Shen, F; Zhao, J; Zhao, M

    2016-02-01

    Higher serum levels of uric acid are associated with preeclampsia and may signal an early change in preeclampsia. However there is less evidence suggesting there is a meaningful association between uric acid and the development of preeclampsia. A total of 877 women with preeclampsia at presentation and 580 normotensive pregnancies were retrospectively recruited from January 2009 to May 2014. In addition, 5556 pregnant women were also prospectively recruited from September 2012 to December 2013. Retrospective serum levels of uric acid were obtained from women with preeclampsia at the time of presentation (n=877), and serum levels of uric acid in the first, second and third trimester were prospectively collected in women who later developed preeclampsia (n=78), as well as those who did not (n=5478). The serum levels of uric acid were significantly increased in women with preeclampsia at presentation from retrospective samples and this increase correlated with the time of onset and the severity of preeclampsia. However, in prospective samples, serum levels of uric acid were not increased in the first and second trimesters in women who later developed preeclampsia compared with those who did not. The serum level of uric acid in the first and second trimesters in women who developed preeclampsia was not different. Our results demonstrate that the serum levels of uric acid were only increased after the presentation of clinical symptoms of preeclampsia. Therefore, it is likely that uric acid is not involved in the development of preeclampsia and cannot be an early prediction biomarker of this disease.

  20. Caracterización histopatológica de gastritis asociada a la presencia de Helicobacter spp en estomagos de caballos

    OpenAIRE

    José Cardona Á; Enrique Paredes H; Heriberto Fernández

    2009-01-01

    Objetivo. Caracterizar el tipo de lesión histopatológica asociada a la presencia de Helicobacter spp. en úlceras gástricas de caballos. Materiales y métodos. Se utilizaron 25 muestras de estómagos de caballos con úlceras positivas en 2 o mas pruebas diagnósticas a bacterias curvoespiraladas Helicobacter spp. Se analizó en forma descriptiva el tipo de lesión histopatológica y el grado de la úlcera gástrica, mediante la tinción de hematoxilina-eosina. A todas las muestras, se le determinó su gr...

  1. Monoartritis gotosa de muñeca asociada a necrosis del semilunar: a propósito de un caso clínico

    OpenAIRE

    Olmedo García, N.; Mackenney Carrasco, Enrique

    1994-01-01

    Se presenta un caso de monoartritis de muñeca asociada a imágenes radiológicas de necrosis avascular del semilunar que, tras biopsia de la sinovial, se diagnostica de artritis gotosa. Esta asociación es rara. La alteración metabólica que se produce en la gota da lugar a una sinovitis, que provoca un aumento de presión intraarticular. Esta hiperpresión en el carpo podría determinar una necrosis isquémica del semilunar, pero con una evolución diferente a la enfermedad de Kienböck...

  2. Alteraciones neuropsicológicas asociadas a la diabetes mellitus 2 (dm2) y a sus factores de riesgo en población antioqueña

    OpenAIRE

    Gómez Muñoz, Natalia

    2011-01-01

    Ubicación en Biblioteca USB Medellín: CD-1914t.-- Grupo de Investigación en Salud Comportamental; Línea de Investigación: Neurociencia Cognitiva. La Diabetes Mellitus 2 (DM2) es un trastorno metabólico de múltiples etiologías. Los cambios en el estilo de vida, el envejecimiento progresivo de la población ha contribuido a un aumento significativo de la enfermedad, con una prevalencia mundial de población afectada de casi el 7%. La DM2 ha sido asociada a múltiples complicaciones microvascula...

  3. Fauna silvestre asociada a ganado vacuno doble propósito en sistema de silvopastoreo, Pinto, Magdalena, Colombia

    Directory of Open Access Journals (Sweden)

    Jaime De La Ossa V.

    2011-12-01

    Full Text Available Objetivo. Evaluar la biodiversidad faunística asociada a ganadería vacuna de doble propósito en dos potreros estructurados con Botriochloa pertusa (colosoana como herbácea dominante, uno de ellos plantado con Crescentia cujete (Bignoniaceae como fuente de alimento adicional y otro con escaso y disperso arbolado. Materiales y métodos. El área de estudio está ubicada en el municipio de Pinto, Magdalena. Cada potrero evaluado fue de 10 ha, se mantuvo en cada uno un lote de quince vacas (½ Cebú, ¼ Pardo y ¼ Costeño con Cuernos, la separación entre las áreas muestreadas fue de 500m. Los registros de fauna se condujeron mediante punto fijo de conteo, en diez sitios de avistamiento, durante 20 días continuos, con cubrimiento visual amplio. Al ganado vacuno adulto presente en las dos áreas de trabajo se le realizó un pesaje individual al inicio del trabajo y al final del mismo, con el fin de determinar posibles diferencias entre ellos. Resultados. Estadísticamente el número de individuos y el número de especies presentaron diferencias significativas, siendo mayor la diversidad biológica para el potrero que poseía la plantación de C. cujete, mientras que el peso corporal de las vacas sometidas a pastoreo en las dos áreas no presentó diferencias significativas. Conclusiones. Se demuestra la importancia de este modelo pecuario como promotor de la conservación faunística local al convertirse enrefugio de variadas especies silvestres, al tiempo que mantiene la productividad existente sin alterar el ambiente sustancialmente.

  4. The Role of Neutrophil Activation in Pathogenesis of Preeclampsia

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    To investigate the effect of neutrophil activation on pathogenesis of pre-eclampsia, neutrophil activation was examined by using flow cytometry to assess the CD11b expression and the levels of plasma endothelin-1 (ET-1) and serum NO-2 were also measured by using non-equilibrium radioimmunoassay and by Griess assay in 29 pregnant women with pre-eclampsia and 31 normal pregnant women at third trimester. The expression of neutrophil CD11b was significantly elevated in women with pre-eclampsia as compared with that of normal pregnant women at third trimester. The mean fluorescence index of CD11b was 438.38±179.91 and 326.97±170.14 respectively (P<0.05). The plasma ET-1 level and serum NO 2 concentration in pre-eclampsic women (63.69±48.33 pg/ml and 20.03±4.77 μmol/L, respectively) were both significantly increased as compared with those in the normal pregnancy women (29.98±20.25 pg/ml and 15.47±5.47 μmol/L, respectively, P<0.01). The neutrophil CD11b expression was significantly elevated in pre-eclampsia. The increased neutrophil activation may cause the damage of vascular endothelium and result in NO release compensatory increase in endothelial cells, suggesting that the neutrophil activation may play a key role in pathogenesis of pre-eclampsia.

  5. Podocytes in urine, a novel biomarker of preeclampsia?

    Science.gov (United States)

    Konieczny, Andrzej; Ryba, Monika; Wartacz, Justyna; Czyżewska-Buczyńska, Agnieszka; Hruby, Zbigniew; Witkiewicz, Wojciech

    2013-01-01

    Preeclampsia is a disorder occurring during pregnancy typically after 20 weeks of gestation. It affects both mother and unborn baby in at least 5-8% of all pregnancies. It is a rapidly progressive condition characterized by high blood pressure and the presence of protein in the urine. The symptoms, such as swelling, sudden weight gain, headaches and vision disturbances, are important signs of preeclampsia which can lead to maternal and infant illness and death. It is estimated that this disorder is responsible for 76,000 maternal and 500,000 infant deaths each year. The main hypothesis explaining the development of preeclampsia is the theory of placental hypoxia/ischemia. An imbalance between vascular endothelial growth factor (VEGF) and soluble fms-like tyro-sine kinase-1 (sFlt-1) seems to play a crucial role. Currently there is no way to predict, with certainty whether preeclampsia will develop during a given pregnancy. There is a need for a diagnostic tool which can help to identify and monitor women at risk. There is growing evidence that podocyturia - urinary excretion of viable podocytes may be a useful predictor of preeclampsia. This paper presents facts supporting such a hypothesis.

  6. Preeclampsia: Reflections on How to Counsel About Preventing Recurrence.

    Science.gov (United States)

    Costa, Maria Laura

    2015-10-01

    Preeclampsia is one of the most challenging diseases of pregnancy, with unclear etiology, no specific marker for prediction, and no precise treatment besides delivery of the placenta. Many risk factors have been identified, and diagnostic and management tools have improved in recent years. However, this disease remains one of the leading causes of maternal morbidity and mortality worldwide, especially in under-resourced settings. A history of previous preeclampsia is a known risk factor for a new event in a future pregnancy, with recurrence rates varying from less than 10% to 65%, depending on the population or methodology considered. A recent review that performed an individual participant data meta-analysis on the recurrence of hypertensive disorders of pregnancy in over 99 000 women showed an overall recurrence rate of 20.7%; when specifically considering preeclampsia, it was 13.8%, with milder disease upon recurrence. Prevention of recurrent preeclampsia has been attempted by changes in lifestyle, dietary supplementation, antihypertensive drugs, antithrombotic agents, and others, with much uncertainty about benefit. It is always challenging to treat and counsel a woman with a previous history of preeclampsia; this review will be based on hypothetical clinical cases, using common scenarios in obstetrical practice to consider the available evidence on how to counsel each woman during pre-conception and prenatal consultations.

  7. Programa hospitalario-domiciliario de entrenamiento al esfuerzo en pacientes con EPOC

    OpenAIRE

    García García, Almudena

    2013-01-01

    La enfermedad pulmonar obstructiva crónica (EPOC), es una entidad caracterizada esencialmente por una limitación crónica al flujo aéreo, no reversible, asociada a una respuesta inflamatoria anormal de los pulmones a partículas nocivas y gases. Los pacientes con EPOC tienen una importante pérdida de calidad de vida relacionada con la salud (CVRS), consecuencia de la limitación respiratoria y de las comorbilidades sistémicas asociadas, que derivan en el desarrollo de miedo y ansiedad ante el es...

  8. Caracterización molecular de la microbiota asociada al queso cotija

    OpenAIRE

    Barrera Chavez, Hugo

    2013-01-01

    El presente trabajo contempla la caracterización fenotípica y molecular de la microbiota asociada al proceso de elaboracion del queso cotija. Para esto, se obtuvieron 27 aislamientos pertenecientes a bacterias (16) y a levaduras (11).

  9. Realidad del ámbito fisioterapéutico de los centros e instituciones en el cantón Babahoyo y propuesta de guía dirigida a padres de familia de los niños de 0-8 años de edad con parálisis cerebral asociada a la baja visión, orientada a fomentar el desarrollo locomotor.

    OpenAIRE

    Mora Mora, Ana Lucía

    2014-01-01

    Este trabajo de tesis se lo efectúo en la ciudad de Babahoyo en la escuela de educación especial a “ayúdanos a empezar” abordando el tema de la parálisis cerebral y la baja visión desde la intervención fisioterapéutica dando respuesta a la problemática que los padres no apoyan en el hogar con los ejercicios para el desarrollo motor de los niños. Con los resultados obtenidos de las encuestas aplicadas a docente, padres de familia, fisioterapeutas y un test locomotor para los niños, se confir...

  10. Peptidomic Identification of Serum Peptides Diagnosing Preeclampsia.

    Directory of Open Access Journals (Sweden)

    Qiaojun Wen

    Full Text Available We sought to identify serological markers capable of diagnosing preeclampsia (PE. We performed serum peptide analysis (liquid chromatography mass spectrometry of 62 unique samples from 31 PE patients and 31 healthy pregnant controls, with two-thirds used as a training set and the other third as a testing set. Differential serum peptide profiling identified 52 significant serum peptides, and a 19-peptide panel collectively discriminating PE in training sets (n = 21 PE, n = 21 control; specificity = 85.7% and sensitivity = 100% and testing sets (n = 10 PE, n = 10 control; specificity = 80% and sensitivity = 100%. The panel peptides were derived from 6 different protein precursors: 13 from fibrinogen alpha (FGA, 1 from alpha-1-antitrypsin (A1AT, 1 from apolipoprotein L1 (APO-L1, 1 from inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4, 2 from kininogen-1 (KNG1, and 1 from thymosin beta-4 (TMSB4. We concluded that serum peptides can accurately discriminate active PE. Measurement of a 19-peptide panel could be performed quickly and in a quantitative mass spectrometric platform available in clinical laboratories. This serum peptide panel quantification could provide clinical utility in predicting PE or differential diagnosis of PE from confounding chronic hypertension.

  11. Pathogenesis of Preeclampsia: The Genetic Component

    Directory of Open Access Journals (Sweden)

    Francisco J. Valenzuela

    2012-01-01

    Full Text Available Preeclampsia (PE is one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40% of births delivered before 35 weeks of gestation. PE begins with inadequate trophoblast invasion early in pregnancy, which produces an increase in oxidative stress contributing to the development of systemic endothelial dysfunction in the later phases of the disease, leading to the characteristic clinical manifestation of PE. Numerous methods have been used to predict the onset of PE with different degrees of efficiency. These methods have used fetal/placental and maternal markers in different stages of pregnancy. From an epidemiological point of view, many studies have shown that PE is a disease with a strong familiar predisposition, which also varies according to geographical, socioeconomic, and racial features, and this information can be used in the prediction process. Large amounts of research have shown a genetic association with a multifactorial polygenic inheritance in the development of this disease. Many biological candidate genes and polymorphisms have been examined in their relation with PE. We will discuss the most important of them, grouped by the different pathogenic mechanisms involved in PE.

  12. RELACIÓN DE LOS HÁBITOS HIGIÉNICO – DIETÉTICOS Y LATERALIDAD MOTORA CON LA DESMINERALIZACIÓN DURANT E EL TRATAMIENTO ORTODÓNCICO CON APARATOLOGÍA FIJA

    OpenAIRE

    VALENZUELA BENÍTEZ, DULCE YADIRA

    2013-01-01

    Con lo anteriormente descrito , es importante para los ortodoncistas investigar la desmineralización asociada a los factores ya mencionados en pacientes con 6 aparatología ortodónti ca fija y así realizar un manejo adecuado durant e el tratamiento

  13. Prediction of the preeclampsia: a view of biochemical markers

    Directory of Open Access Journals (Sweden)

    Mehmet Sühha Bostancı

    2013-10-01

    Full Text Available Preeclampsia is a diverse, multiorgan group of related disease processes that occurs in up to 5%-8% of pregnancies after 20 weeks’ gestation and it is one of the leading causes of maternal and fetal morbidity and mortality. Many molecular mechanisms are contributed to the pathogenesis of preeclampsia. Although it is unknown whether the mechanisms act independently or have synergistic effects. This review describes review of primary papers investigating blood based biomarker such as PAP-A, Inhibin A, sFlt1, and PP13 in general and first trimester biochemical markers and combinations of them specifically for preeclampsia.http://dx.doi.org/10.7175/rhc.v4i4.699

  14. Severe Preeclampsia in the Setting of Myasthenia Gravis

    Science.gov (United States)

    Keeney, Renée

    2017-01-01

    Myasthenia gravis (MG) is a rare autoimmune disease that leads to progressive muscle weakness and is common during female reproductive years. The myasthenic mother and her newborn must be observed carefully, as complications during all stages of pregnancy and the puerperium may arise suddenly. Preeclampsia is a common obstetrical condition for which magnesium sulfate is used for seizure prophylaxis. However, magnesium sulfate is strongly contraindicated in MG as it impairs already slowed nerve-muscle connections. Similarly, many first-line antihypertensive medications, including calcium channels blockers and β-blockers, may lead to MG exacerbation. This case describes the effective obstetrical management of a patient with MG who developed severe preeclampsia. The effective use of levetiracetam and various antihypertensive medications including intravenous labetalol is described. A review of the ten reported cases of MG complicated by preeclampsia is examined to aggregate observations of clinical care, with focus on delivery methods, anticonvulsants, and antihypertensive medications. PMID:28280642

  15. Severe Preeclampsia in the Setting of Myasthenia Gravis

    Directory of Open Access Journals (Sweden)

    Adam J. Lake

    2017-01-01

    Full Text Available Myasthenia gravis (MG is a rare autoimmune disease that leads to progressive muscle weakness and is common during female reproductive years. The myasthenic mother and her newborn must be observed carefully, as complications during all stages of pregnancy and the puerperium may arise suddenly. Preeclampsia is a common obstetrical condition for which magnesium sulfate is used for seizure prophylaxis. However, magnesium sulfate is strongly contraindicated in MG as it impairs already slowed nerve-muscle connections. Similarly, many first-line antihypertensive medications, including calcium channels blockers and β-blockers, may lead to MG exacerbation. This case describes the effective obstetrical management of a patient with MG who developed severe preeclampsia. The effective use of levetiracetam and various antihypertensive medications including intravenous labetalol is described. A review of the ten reported cases of MG complicated by preeclampsia is examined to aggregate observations of clinical care, with focus on delivery methods, anticonvulsants, and antihypertensive medications.

  16. Problemas y necesidades relacionados con la salud en personas con discapacidad intelectual

    OpenAIRE

    Mirón, J.A.; et al.

    2005-01-01

    El objetivo del estudio es valorar los problemas y necesidades de Salud en personas adultas con discapacidad intelectual (PADI). Se evidencia la asociación de comorbilidad asociada a discapacidad intelectual con una alta prevalencia de enfermedades cardiovasculares, neurológicas y osteomusculares. El factor de riesgo más importante es el sobrepeso y la obesidad. La demanda de consulta médica es alta y la consulta al dentista es baja; ambas se asocian significativamente al bajo nivel socioecon...

  17. Outcome and risk factors of early onset severe preeclampsia

    Institute of Scientific and Technical Information of China (English)

    GONG Yun-hui; JIA Jin; L(U) Dong-hao; DAI Li; BAI Yi; ZHOU Rong

    2012-01-01

    Background Early onset severe preeclampsia is a specific type of severe preeclampsia,which causes high morbidity and mortality of both mothers and fetus.This study aimed to investigate the clinical definition,features,treatment,outcome and risk factors of early onset severe preaclampsia in Chinese women.üMethods Four hundred and thirteen women with severe preeclampsia from June 2006 to June 2009 were divided into three groups according to the gestational age at the onset of preeclampsia as follows:group A (less than 32 weeks,73 cases),group B (between 32 and 34 weeks,71 cases),and group C (greater than 34 weeks,269 cases).The demographic characteristics of the subjects,complications,delivery modes and outcome of pregnancy were analyzed retrospectively.üResults The systolic blood pressure at admission and the incidence of severe complications were significantly lower in group C than those in groups A and B,prolonged gestational weeks and days of hospitalization were significantly shorter in group C than those in groups A and B.Liver and kidney dysfunction,pleural and peritoneal effusion,placental abruption and postpartum hemorrhage were more likely to occur in group A compared with the other two groups.Twenty-four-hour urine protein levels at admission,intrauterine fetal death and days of hospitalization were risk factors that affected complications of severe preeclampsia.Gestational week at admission and delivery week were also risk factors that affected perinatal outcome.Conclusions Early onset severe preeclampsia should be defined as occurring before 34 weeks,and it is featured by more maternal complications and a worse perinatal prognosis compared with that defined as occurring after 34 weeks.Independent risk factors should be used to tailor the optimized individual treatment plan,to balance both maternal and neonatal safety.

  18. Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers.

    LENUS (Irish Health Repository)

    Kenny, Louise C

    2010-09-13

    Preeclampsia is a pregnancy-specific syndrome that causes substantial maternal and fetal morbidity and mortality. The etiology is incompletely understood, and there is no clinically useful screening test. Current metabolomic technologies have allowed the establishment of metabolic signatures of preeclampsia in early pregnancy. Here, a 2-phase discovery\\/validation metabolic profiling study was performed. In the discovery phase, a nested case-control study was designed, using samples obtained at 15±1 weeks\\' gestation from 60 women who subsequently developed preeclampsia and 60 controls taking part in the prospective Screening for Pregnancy Endpoints cohort study. Controls were proportionally population matched for age, ethnicity, and body mass index at booking. Plasma samples were analyzed using ultra performance liquid chromatography-mass spectrometry. A multivariate predictive model combining 14 metabolites gave an odds ratio for developing preeclampsia of 36 (95% CI: 12 to 108), with an area under the receiver operator characteristic curve of 0.94. These findings were then validated using an independent case-control study on plasma obtained at 15±1 weeks from 39 women who subsequently developed preeclampsia and 40 similarly matched controls from a participating center in a different country. The same 14 metabolites produced an odds ratio of 23 (95% CI: 7 to 73) with an area under receiver operator characteristic curve of 0.92. The finding of a consistent discriminatory metabolite signature in early pregnancy plasma preceding the onset of preeclampsia offers insight into disease pathogenesis and offers the tantalizing promise of a robust presymptomatic screening test.

  19. Complement factor B activation in patients with preeclampsia.

    Science.gov (United States)

    Velickovic, Ivan; Dalloul, Mudar; Wong, Karen A; Bakare, Olufunke; Schweis, Franz; Garala, Maya; Alam, Amit; Medranda, Giorgio; Lekovic, Jovana; Shuaib, Waqas; Tedjasukmana, Andreas; Little, Perry; Hanono, Daniel; Wijetilaka, Ruvini; Weedon, Jeremy; Lin, Jun; Toledano, Roulhac d'Arby; Zhang, Ming

    2015-06-01

    Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators. We hypothesized that the disagreement in findings may be due to the racial/ethnic differences among various study groups, and that fB activation is significant in women of an ethnic minority with preeclampsia. We investigated the maternal and fetal levels of Bb (the activated fB fragment) in pregnant women of an ethnic minority with or without preeclampsia. We enrolled 291 pregnant women (96% of an ethnic minority, including 78% African-American). Thirteen percent of these were diagnosed with preeclampsia. Maternal venous blood was collected from all participants together with fetal umbilical cord blood samples from 154 deliveries in the 291 women. The results were analyzed using the Mann-Whitney U test and multivariate analyses. Maternal Bb levels were significantly higher in the preeclamptic group than in the nonpreeclamptic group. Levels of Bb in fetal cord blood were similar in both groups. Subgroup analyses of African-American patients' results confirmed the study hypothesis that there would be a significant increase in Bb in the maternal blood of the preeclamptic group and no increase in Bb in the fetal cord blood of this group. These results suggest that a maternal immune response through complement fB might play a role in the development of preeclampsia, particularly in African-American patients.

  20. Heart Rate Variability and Autonomic Modulations in Preeclampsia.

    Directory of Open Access Journals (Sweden)

    Shaza M Musa

    Full Text Available Although the exact pathophysiology of preeclampsia is not well understood, autonomic nervous system imbalance is suggested as one of the main factors.To investigate heart rate variability (HRV and autonomic modulations in Sudanese pregnant women with preeclampsia.A case-control study (60 women in each arm was conducted at Omdurman Maternity Hospital-Sudan, during the period from June to August, 2014. Cases were women presented with preeclampsia and healthy pregnant women were the controls. Studied groups were matched for important determinants of HRV. Natural logarithm (Ln of total power (TP, high frequency (HF, low frequency (LF and very low frequency (VLF were used to determine HRV. Normalized low and high frequencies (LF Norm and HF Norm were used to evaluate sympathetic and parasympathetic autonomic modulations respectively.Patients with preeclampsia achieved significantly higher LF Norm [49.80 (16.25 vs. 44.55 (19.15, P = 0.044] and LnLF/HF [0.04 (0.68 vs. -0.28 (0.91, P = 0.023] readings, but lower HF Norm [49.08 (15.29 vs. 55.87 (19.56, P = 0.012], compared with healthy pregnant women. Although all other HRV measurements were higher in the patients with preeclampsia compared with the controls, only LnVLF [4.50 (1.19 vs. 4.01 (1.06, P = 0.017] and LnLF [4.01 (1.58 vs. 3.49 (1.23, P = 0.040] reached statistical significance.The study adds further evidence for the dominant cardiac sympathetic modulations on patients with preeclampsia, probably secondary to parasympathetic withdrawal in this group. However, the higher LnVLF and LnLF readings achieved by preeclamptic women compared with the controls are unexpected in the view that augmented sympathetic modulations usually depresses all HRV parameters including these two measures.

  1. Heart Rate Variability and Autonomic Modulations in Preeclampsia

    Science.gov (United States)

    Musa, Shaza M.; Adam, Ishag; Lutfi, Mohamed F.

    2016-01-01

    Background Although the exact pathophysiology of preeclampsia is not well understood, autonomic nervous system imbalance is suggested as one of the main factors. Aims To investigate heart rate variability (HRV) and autonomic modulations in Sudanese pregnant women with preeclampsia. Subjects and Methods A case-control study (60 women in each arm) was conducted at Omdurman Maternity Hospital—Sudan, during the period from June to August, 2014. Cases were women presented with preeclampsia and healthy pregnant women were the controls. Studied groups were matched for important determinants of HRV. Natural logarithm (Ln) of total power (TP), high frequency (HF), low frequency (LF) and very low frequency (VLF) were used to determine HRV. Normalized low and high frequencies (LF Norm and HF Norm) were used to evaluate sympathetic and parasympathetic autonomic modulations respectively. Results Patients with preeclampsia achieved significantly higher LF Norm [49.80 (16.25) vs. 44.55 (19.15), P = 0.044] and LnLF/HF [0.04 (0.68) vs. -0.28 (0.91), P = 0.023] readings, but lower HF Norm [49.08 (15.29) vs. 55.87 (19.56), P = 0.012], compared with healthy pregnant women. Although all other HRV measurements were higher in the patients with preeclampsia compared with the controls, only LnVLF [4.50 (1.19) vs. 4.01 (1.06), P = 0.017] and LnLF [4.01 (1.58) vs. 3.49 (1.23), P = 0.040] reached statistical significance. Conclusion The study adds further evidence for the dominant cardiac sympathetic modulations on patients with preeclampsia, probably secondary to parasympathetic withdrawal in this group. However, the higher LnVLF and LnLF readings achieved by preeclamptic women compared with the controls are unexpected in the view that augmented sympathetic modulations usually depresses all HRV parameters including these two measures. PMID:27043306

  2. A new mouse model to explore therapies for preeclampsia.

    Directory of Open Access Journals (Sweden)

    Abdulwahab Ahmed

    Full Text Available BACKGROUND: Pre-eclampsia, a pregnancy-specific multisystemic disorder is a leading cause of maternal and perinatal mortality and morbidity. This syndrome has been known to medical science since ancient times. However, despite considerable research, the cause/s of preeclampsia remain unclear, and there is no effective treatment. Development of an animal model that recapitulates this complex pregnancy-related disorder may help to expand our understanding and may hold great potential for the design and implementation of effective treatment. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that the CBA/J x DBA/2 mouse model of recurrent miscarriage is also a model of immunologically-mediated preeclampsia (PE. DBA/J mated CBA/J females spontaneously develop many features of human PE (primigravidity, albuminuria, endotheliosis, increased sensitivity to angiotensin II and increased plasma leptin levels that correlates with bad pregnancy outcomes. We previously reported that antagonism of vascular endothelial growth factor (VEGF signaling by soluble VEGF receptor 1 (sFlt-1 is involved in placental and fetal injury in CBA/J x DBA/2 mice. Using this animal model that recapitulates many of the features of preeclampsia in women, we found that pravastatin restores angiogenic balance, ameliorates glomerular injury, diminishes hypersensitivity to angiotensin II and protects pregnancies. CONCLUSIONS/SIGNIFICANCE: We described a new mouse model of PE, were the relevant key features of human preeclampsia develop spontaneously. The CBA/J x DBA/2 model, that recapitulates this complex disorder, helped us identify pravastatin as a candidate therapy to prevent preeclampsia and its related complications. We recognize that these studies were conducted in mice and that clinical trials are needed to confirm its application to humans.

  3. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers.

    LENUS (Irish Health Repository)

    Kenny, Louise C

    2012-01-31

    Preeclampsia is a pregnancy-specific syndrome that causes substantial maternal and fetal morbidity and mortality. The etiology is incompletely understood, and there is no clinically useful screening test. Current metabolomic technologies have allowed the establishment of metabolic signatures of preeclampsia in early pregnancy. Here, a 2-phase discovery\\/validation metabolic profiling study was performed. In the discovery phase, a nested case-control study was designed, using samples obtained at 15+\\/-1 weeks\\' gestation from 60 women who subsequently developed preeclampsia and 60 controls taking part in the prospective Screening for Pregnancy Endpoints cohort study. Controls were proportionally population matched for age, ethnicity, and body mass index at booking. Plasma samples were analyzed using ultra performance liquid chromatography-mass spectrometry. A multivariate predictive model combining 14 metabolites gave an odds ratio for developing preeclampsia of 36 (95% CI: 12 to 108), with an area under the receiver operator characteristic curve of 0.94. These findings were then validated using an independent case-control study on plasma obtained at 15+\\/-1 weeks from 39 women who subsequently developed preeclampsia and 40 similarly matched controls from a participating center in a different country. The same 14 metabolites produced an odds ratio of 23 (95% CI: 7 to 73) with an area under receiver operator characteristic curve of 0.92. The finding of a consistent discriminatory metabolite signature in early pregnancy plasma preceding the onset of preeclampsia offers insight into disease pathogenesis and offers the tantalizing promise of a robust presymptomatic screening test.

  4. Deconstructing the smoking-preeclampsia paradox through a counterfactual framework.

    Science.gov (United States)

    Luque-Fernandez, Miguel Angel; Zoega, Helga; Valdimarsdottir, Unnur; Williams, Michelle A

    2016-06-01

    Although smoking during pregnancy may lead to many adverse outcomes, numerous studies have reported a paradoxical inverse association between maternal cigarette smoking during pregnancy and preeclampsia. Using a counterfactual framework we aimed to explore the structure of this paradox as being a consequence of selection bias. Using a case-control study nested in the Icelandic Birth Registry (1309 women), we show how this selection bias can be explored and corrected for. Cases were defined as any case of pregnancy induced hypertension or preeclampsia occurring after 20 weeks' gestation and controls as normotensive mothers who gave birth in the same year. First, we used directed acyclic graphs to illustrate the common bias structure. Second, we used classical logistic regression and mediation analytic methods for dichotomous outcomes to explore the structure of the bias. Lastly, we performed both deterministic and probabilistic sensitivity analysis to estimate the amount of bias due to an uncontrolled confounder and corrected for it. The biased effect of smoking was estimated to reduce the odds of preeclampsia by 28 % (OR 0.72, 95 %CI 0.52, 0.99) and after stratification by gestational age at delivery ( 1, revealing the structure of the paradox. The bias-adjusted estimation of the smoking effect on preeclampsia showed an OR of 1.22 (95 %CI 0.41, 6.53). The smoking-preeclampsia paradox appears to be an example of (1) selection bias most likely caused by studying cases prevalent at birth rather than all incident cases from conception in a pregnancy cohort, (2) omitting important confounders associated with both smoking and preeclampsia (preventing the outcome to develop) and (3) controlling for a collider (gestation weeks at delivery). Future studies need to consider these aspects when studying and interpreting the association between smoking and pregnancy outcomes.

  5. Resibufogenin corrects hypertension in a rat model of human preeclampsia.

    Science.gov (United States)

    Vu, Hop; Ianosi-Irimie, Monica; Danchuk, Svitlana; Rabon, Edd; Nogawa, Toshihiko; Kamano, Yoshiaki; Pettit, G Robert; Wiese, Thomas; Puschett, Jules B

    2006-02-01

    The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.

  6. Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids in preeclampsia.

    Science.gov (United States)

    Das, Undurti N

    2015-09-01

    Preeclampsia is a low-grade systemic inflammatory condition in which oxidative stress and endothelial dysfunction occurs. Plasma levels of soluble receptor for vascular endothelial growth factor (VEGFR)-1, also known as sFlt1 (soluble fms-like tyrosine kinase 1), an antiangiogenic factor have been reported to be elevated in preeclampsia. It was reported that pregnant mice deficient in catechol-O-methyltransferase (COMT) activity show a preeclampsia-like phenotype due to a deficiency or absence of 2-methoxyoestradiol (2-ME), a natural metabolite of estradiol that is elevated during the third trimester of normal human pregnancy. Additionally, autoantibodies (AT1-AAs) that bind and activate the angiotensin II receptor type 1 a (AT1 receptor) also have a role in preeclampsia. None of these abnormalities are consistently seen in all the patients with preeclampsia and some of them are not specific to pregnancy. Preeclampsia could occur due to an imbalance between pro- and antiangiogenic factors. VEGF, an angiogenic factor, is necessary for the transport of polyunsaturated fatty acids (PUFAs) to endothelial cells. Hence reduced VEGF levels decrease the availability of PUFAs to endothelial cells. This leads to a decrease in the formation of anti-inflammatory and angiogenic factors: lipoxins, resolvins, protectins, and maresins from PUFAs. Lipoxins, resolvins, protectins, maresins, and PUFAs suppress insulin resistance; activation of leukocytes, platelets, and macrophages; production of interleukin-6 and tumor necrosis factor-α; and oxidative stress and endothelial dysfunction; and enhance production of prostacyclin and nitric oxide (NO). Estrogen enhances the formation of lipoxin A4 and NO. PUFAs also augment the production of NO and inhibit the activity of angiotensin-converting enzyme and antagonize the actions of angiotensin II. Thus, PUFAs can prevent activation of angiotensin II receptor type 1 a (AT1 receptor). Patients with preeclampsia have decreased plasma

  7. Efecto de la cobertura de rastrojos en la germinación del arroz (Oryza sativa L. y principales malezas asociadas

    Directory of Open Access Journals (Sweden)

    Yemel M. Ortega

    2005-01-01

    Full Text Available Efecto de la cobertura de rastrojos en la germinacióndel arroz (Oryza sativaL. y principales malezas asociadas. Para determinar el grado de interferencia causado por distintas cantidades de rastrojos de arroz (Oryza sativaL. sobrela emergencia de arroz y malezas asociadas al cultivo, en el2003 se realizaron tres experimentos simultáneos en la hacienda el Pelón de la Bajura, Guanacaste, Costa Rica. Se aplicaron nueve tratamientos (0 a 9 t/ha de coberturas con rastrojosde la variedad de arroz CR 1113 para medir los efectos en laemergencia del arroz y malezas. Las malezas asociadas incluyen las más frecuentes en agroecosistemas arroceros inundados: Oryza sativa, Echinochloa colona, Cyperusspp., Fim-bristylisspp., Ludwigiaspp. y Heteranthera limosa. En losprimeros dos experimentos se determinaron relaciones inversas entre el grado de cobertura y la densidad de plántulas demalezas emergidas (R2>0,89, y entre el grado de cobertura yel porcentaje de germinación del arroz (R2=0,86, respectivamente. Usando coberturas con rastrojos de frijol (Phaseolusvulgaris en el tercer experimento, no se observó efecto supresor en la germinación del arroz, probablemente debido a supronta descomposición. Aunque la germinación del arroz nose afectó aún a las intensidades más altas de rastrojos evaluadas, conviene realizar pruebas similares a largo plazo para determinar posibles efectos debidos a la descomposición de residuos, alelopatía y acarreo de herbicidas después de variosciclos consecutivos del cultivo de arroz.

  8. Higher risk of pre-eclampsia after change of partner. An effect of longer interpregnancy intervals?

    DEFF Research Database (Denmark)

    Basso, Olga; Christensen, Kaare; Olsen, J.

    2001-01-01

    Epidemiologic studies have shown that pre-eclampsia is mainly a disease of first pregnancy, possibly associated with primipaternity. The interpregnancy interval, which is strongly associated with change of partner, has received little attention. In this study, based on Danish hospital records, we...... evaluated whether the interpregnancy interval may confound or modify the paternal effect on pre-eclampsia. We studied the outcome of the second birth in a cohort of Danish women with pre-eclampsia in the previous birth (8,401 women) and in all women with pre-eclampsia in second (but not first) birth...... together with a sample of women with two births (26,596 women). A long interpregnancy interval was associated with a higher risk of pre-eclampsia in women with no previous pre-eclampsia when the father was the same. We estimated the risk of pre-eclampsia in second birth according to paternal change...

  9. Long-term impact of preeclampsia on maternal endometrial cancer risk

    DEFF Research Database (Denmark)

    Hallum, Sara; Pinborg, Anja; Kamper-Jørgensen, Mads

    2016-01-01

    BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk. METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during...... 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models. RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk...... (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)). CONCLUSIONS: Although we report no obvious...

  10. Diagnosis of preeclampsia with soluble Fms-like tyrosine kinase 1/placental growth factor ratio

    DEFF Research Database (Denmark)

    Andersen, Louise Bjørkholt; Frederiksen-Møller, Britta; Work Havelund, Kathrine;

    2015-01-01

    The angiogenic factor ratio soluble Fms-kinase 1 (sFlt-1)/placental growth factor (PlGF) is a novel diagnostic tool for preeclampsia. We compared the efficacy of the KRYPTOR (BRAHMS) automated assays for sFlt-1 and PlGF with the Elecsys (Roche) assays in a routine clinical setting. Preeclamptic...... = .047). For early-onset preeclampsia, KRYPTOR area under the curve increased to 0.929 with a 100% specificity for preeclampsia at cut-off 85 and an 88.9% sensitivity for preeclampsia at cut-off 33. For women with preeclampsia and preterm delivery or Hemolysis, Elevated Liver enzymes, Low Platelet count...... (HELLP) syndrome, the KRYPTOR sFlt-1/PlGF ratio was manifold increased (P preeclampsia, preeclampsia with preterm delivery or HELLP, and among non-obese women....

  11. Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension.

    Science.gov (United States)

    Veerbeek, Jan H W; Hermes, Wietske; Breimer, Anath Y; van Rijn, Bas B; Koenen, Steven V; Mol, Ben W; Franx, Arie; de Groot, Christianne J M; Koster, Maria P H

    2015-03-01

    Observational studies have shown an increased lifetime risk of cardiovascular disease (CVD) in women who experienced a hypertensive disorder in pregnancy. This risk is related to the severity of the pregnancy-related hypertensive disease and gestational age at onset. However, it has not been investigated whether these differences in CVD risk factors are already present at postpartum cardiovascular screening. We evaluated postpartum differences in CVD risk factors in 3 subgroups of patients with a history of hypertensive pregnancy. We compared the prevalence of common CVD risk factors postpartum among 448 women with previous early-onset preeclampsia, 76 women with previous late-onset preeclampsia, and 224 women with previous pregnancy-induced hypertension. Women with previous early-onset preeclampsia were compared with women with late-onset preeclampsia and pregnancy-induced hypertension and had significantly higher fasting blood glucose (5.29 versus 4.80 and 4.83 mmol/L), insulin (9.12 versus 6.31 and 6.7 uIU/L), triglycerides (1.32 versus 1.02 and 0.97 mmol/L), and total cholesterol (5.14 versus 4.73 and 4.73 mmol/L). Almost half of the early-onset preeclampsia women had developed hypertension, as opposed to 39% and 25% of women in the pregnancy-induced hypertension and late-onset preeclampsia groups, respectively. Our data show differences in the prevalence of common modifiable CVD risk factors postpartum and suggest that prevention strategies should be stratified according to severity and gestational age of onset for the hypertensive disorders of pregnancy.

  12. Renal Evaluation in Women with Preeclampsia

    Directory of Open Access Journals (Sweden)

    T.A. Facca

    2012-05-01

    Full Text Available Background/Aims: Preeclampsia (PE is a cause of glomerulopathy worldwide. Urinary retinol-binding protein (RBP is a marker of proximal tubular dysfunction, albuminuria is an endothelial injury marker, urine protein:creatinine ratio (PCR may have a predictive value for renal disease later in life, and, recently, podocyturia has been proposed as a sensitive tool in pregnancy, but it needs to be tested. The aim of this study was to evaluate renal involvement in PE and healthy pregnancy. Methods: Case-control study with 39 pregnant women assessed after 20 weeks of gestation (25 in the control group, CG, and 14 in the PE group by performing urinary tests. Results: Mean (±SD age and gestational age of the CG were 26.9 ± 6.4 years and 37.1 ± 5.0 weeks, and of the PE group 26.4 ± 6.9 years and 30.6 ± 5.6 weeks, respectively (p = 0.001. Mean (±SD urinary RBP (p = 0.017, albuminuria (p = 0.002, and urinary albumin concentration (UAC ratio (p = 0.006 of the CG were 0.4 ± 0.7 mg/l, 7.3 ± 6.9 mg/l, and 8.2 ± 6.7 mg/g and of the PE group 2.0 ± 4.4 mg/l, 2,267.4 ± 2,130.8 mg/l (p = 0.002, and 3,778.9 ± 4,296.6 mg/g (p = 0.006, respectively. Mean (±SD urine PCR in the PE group was 6.7 ± 6.1 g/g (p Conclusions: Urinary RBP, PCR, albuminuria, and UAC ratio were elevated in the PE group in comparison to the CG. Podocyturia did not predict PE.

  13. Immune Mechanisms Linking Obesity and Preeclampsia

    Directory of Open Access Journals (Sweden)

    Frank T. Spradley

    2015-11-01

    Full Text Available Preeclampsia (PE is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal morbidity and mortality in developing countries and its pervasiveness is increasing within developed countries including the USA. However, the mechanisms mediating the pathogenesis of this maternal disorder and its rising prevalence are far from clear. A major theory with strong experimental evidence is that placental ischemia, resulting from inappropriate remodeling and widening of the maternal spiral arteries, stimulates the release of soluble factors from the ischemic placenta causing maternal endothelial dysfunction and hypertension. Aberrant maternal immune responses and inflammation have been implicated in each of these stages in the cascade leading to PE. Regarding the increased prevalence of this disease, it is becoming increasingly evident from epidemiological data that obesity, which is a state of chronic inflammation in itself, increases the risk for PE. Although the specific mechanisms whereby obesity increases the rate of PE are unclear, there are strong candidates including activated macrophages and natural killer cells within the uterus and placenta and activation in the periphery of T helper cells producing cytokines including TNF-α, IL-6 and IL-17 and the anti-angiogenic factor sFlt-1 and B cells producing the agonistic autoantibodies to the angiotensin type 1 receptor (AT1-aa. This review will focus on the immune mechanisms that have been implicated in the pathogenesis of hypertension in PE with an emphasis on the potential importance of inflammatory factors in the increased risk of developing PE in obese pregnancies.

  14. Infección adquirida en una Unidad de Cuidados Intensivos. Análisis descriptivo y con minería de datos

    OpenAIRE

    Ballesteros Herráez, Juan Carlos

    2016-01-01

    [ES]Las infecciones asociadas a los cuidados sanitarios constituyen uno de los efectos adversos más frecuentemente ligados con la hospitalización. En el ámbito de las unidades de cuidados intensivos (UCI), su incidencia es mayor que en otras áreas del hospital. Mediante los programas de vigilancia de la infección nosocomial (en nuestro caso el ENVIN), podemos conocer las tasas de infección adquirida en UCI, especialmente las asociadas a dispositivos invasivos como son: las neumonías asociadas...

  15. MORBILIDAD Y MORTALIDAD NEONATAL ASOCIADA A LA DIABETES GESTACIONAL

    OpenAIRE

    Velázquez G,Pablo; Vega M,Genaro; Martínez M,Martha Leticia

    2010-01-01

    Objetivo: Determinar la asociación de la morbilidad y mortalidad neonatal con la diabetes gestacional. Método: Estudio tipo cohortes. Se realizó un estudio en embarazadas desde diciembre de 2007 a noviembre de 2008 en el servicio de tococirugía del Hospital General Regional No. 1 de Querétaro, México, se formaron dos grupos de 71 pacientes, uno con diabetes gestacional y otro sin ella. El muestreo fue por cuota pareado por edad. En ambos grupos se midieron variables sociodemográficas, anteced...

  16. Terapia asistida con perros en niños con autismo revisión sistemática

    OpenAIRE

    Isaza Narváez, Ana Milena; Muñoz Chilito, Doumer Adrian

    2013-01-01

    Introducción: El autismo es un trastorno temprano y masivo del desarrollo en el cual se afecta la interacción social, el desarrollo del lenguaje, se presentan rituales y estereotipias. Hay evidencia que la interacción con un perro está asociada con efectos positivos en la salud del niño, lo cual se extiende al terreno terapéutico donde la compañía del perro estimula habilidades comunicativas para conectarse con el mundo exterior y romper el aislamiento que lo hace refractario a formas convenc...

  17. Increased cerebral blood flow in preeclampsia with magnetic resonance imaging

    NARCIS (Netherlands)

    Zeeman, GG; Hatab, MR; Twickler, DM

    2004-01-01

    Objective: The purpose of this study was to compare third trimester and nonpregnant cerebral blood flow of women with preeclampsia to normotensive control subjects with the use of magnetic resonance imaging techniques. Study design: Nine normotensive pregnant women and 12 untreated women with preecl

  18. Regional changes of placental vascularization in preeclampsia: a review.

    Science.gov (United States)

    Sahay, Akriti S; Sundrani, Deepali P; Joshi, Sadhana R

    2015-08-01

    Preeclampsia is characterized by vascular dysfunction and results in maternal and fetal morbidity and mortality. The placenta plays a critical role in the growth and development of the fetus, and recent studies indicate that placental architecture, oxygen availability, and oxidative stress indices vary across different regions of the placenta. Our earlier studies have reported altered maternal angiogenesis and differential placental gene expression and methylation patterns of angiogenic factors in women with preeclampsia when compared with normotensive women. We have also demonstrated lower maternal and placental neurotrophin (NT) levels in women with preeclampsia. Studies suggest that oxidative stress is associated with proteases like matrix metalloproteinases (MMPs) and growth factors like NTs and angiogenic factors known to be involved in the process of angiogenesis. Recently, we have reported regionwise differential oxidative stress, antioxidant enzyme activity, and NT levels in placenta from normotensive control women and women with preeclampsia. The current review describes the regional changes in the placenta and highlights the role of placental oxidative stress in influencing regional differences in the expression of angiogenic factors, MMPs, and NTs. This review discusses the need for further research on various growth factors and proteins involved in the process of placental development across different regions of the placenta. This would help to understand whether regional differences in these factors affect the growth and development of the fetus.

  19. Preeclampsia – Will Orphan Drug Status Facilitate Innovative Biological Therapies?

    Science.gov (United States)

    Hahn, Sinuhe

    2015-01-01

    It is generally accepted that the development of novel therapies to treat pregnancy-related disorders, such as preeclampsia, is hampered by the paucity of research funding. Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder: exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells. As these projects are being carried out by small biotech enterprises, the question arises of how they are able to fund such undertakings. A novel strategy adopted by two of these companies is that they successfully petitioned US and EU agencies in order that preeclampsia is accepted in the register of rare or orphan diseases. This provides a number of benefits including market exclusivity, assistance with clinical trials, and dedicated funding schemes. Other strategies to supplement meager research funds, especially to test novel approaches, could be crowdfunding, a venture that relies on intimate interaction with advocacy groups. In other words, preeclampsia meets Facebook. Perhaps similar strategies can be adopted to examine novel therapies targeting either the imbalance in pro- or anti-angiogenic growth factors, complement activation, reduced levels of placenta protein 13, or excessive neutrophil activation evident in preeclampsia. PMID:25767802

  20. Preeclampsia - will orphan drug status facilitate innovative biological therapies?

    Science.gov (United States)

    Hahn, Sinuhe

    2015-01-01

    It is generally accepted that the development of novel therapies to treat pregnancy-related disorders, such as preeclampsia, is hampered by the paucity of research funding. Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder: exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells. As these projects are being carried out by small biotech enterprises, the question arises of how they are able to fund such undertakings. A novel strategy adopted by two of these companies is that they successfully petitioned US and EU agencies in order that preeclampsia is accepted in the register of rare or orphan diseases. This provides a number of benefits including market exclusivity, assistance with clinical trials, and dedicated funding schemes. Other strategies to supplement meager research funds, especially to test novel approaches, could be crowdfunding, a venture that relies on intimate interaction with advocacy groups. In other words, preeclampsia meets Facebook. Perhaps similar strategies can be adopted to examine novel therapies targeting either the imbalance in pro- or anti-angiogenic growth factors, complement activation, reduced levels of placenta protein 13, or excessive neutrophil activation evident in preeclampsia.

  1. Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

    DEFF Research Database (Denmark)

    Laigaard, Jennie; Sørensen, Tina; Placing, Sophie;

    2005-01-01

    OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time-resolved, immu......OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time......-resolved, immunofluorometric assay for the quantification of ADAM12 in serum. The assay detected ADAM12 in a range of 78-1248 microg/L. Serum samples derived from women in the first trimester of a normal pregnancy (n = 324) and from women who later developed preeclampsia during pregnancy (n = 160) were obtained from the First...... Trimester Copenhagen Study. ADAM12 levels were assayed in these serum samples. Serum levels of ADAM12 were converted to multiples of the median (MoM) after log-linear regression of concentration versus gestational age. RESULTS: Serum ADAM12 levels in women who developed preeclampsia during pregnancy had...

  2. Emerging Role of Endothelial and Inflammatory Markers in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Menha Swellam

    2009-01-01

    Full Text Available Objectives: Endothelial disturbance and excess inflammatory response are pathogenic mechanisms in pre-eclampsia (PE. Authors determine the clinical diagnostic role for thrombomodulin (TM, plasminogen activator inhibitor-1 (PAI-1 as endothelial markers and C-reactive protein (CRP, and interlukin-6 (IL-6 as inflammatory markers when tested independently or in combinations.

  3. Management of pre-eclampsia: issues for anaesthetists.

    Science.gov (United States)

    Dennis, A T

    2012-09-01

    Pre-eclampsia is a leading cause of maternal morbidity and mortality. Substandard care is often present and many deaths are preventable. The aim of this review is to summarise the key management issues for anaesthetists in the light of the current literature. A systematic literature search of electronic databases was undertaken including MEDLINE, EMBASE and the Cochrane Library using the key words obstetrics, pregnancy, pregnancy complications, maternal, pre-eclampsia, preeclampsia, cardiac function, haemodynamics, haemolysis, elevated liver enzymes, low platelets (HELLP), eclampsia, anaesthesia, anesthesia, neuraxial. Relevant Colleges and Societies websites were examined for pertinent guidelines. The disease is defined within the context of hypertensive diseases, and early recognition of pre-eclampsia and its complications, as well as multidisciplinary expert team management is highlighted. Accurate monitoring and recording of observations including the use of transthoracic echocardiography is discussed. The importance of the treatment of systolic blood pressure>180 mmHg and the use of intravenous antihypertensive medication as well as the use of parenteral magnesium sulphate for the treatment and prevention of eclampsia is emphasised . Restricted intravenous fluid therapy and avoidance of ergometrine is discussed. Neuraxial analgesia and anaesthesia, and general anaesthesia for birth is summarised as well as postpartum management including analgesia, thromboprophylaxis, management of acute pulmonary oedema and the use of pharmacological agents in the setting of breastfeeding.

  4. Etiology and management of postpartum hypertension-preeclampsia.

    Science.gov (United States)

    Sibai, Baha M

    2012-06-01

    Postpartum hypertension can be related to persistence of gestational hypertension, preeclampsia, or preexisting chronic hypertension, or it could develop de novo postpartum secondary to other causes. There are limited data describing the etiology, differential diagnosis, and management of postpartum hypertension-preeclampsia. The differential diagnosis is extensive, and varies from benign (mild gestational or essential hypertension) to life-threatening such as severe preeclampsia-eclampsia, pheochromocytoma, and cerebrovascular accidents. Therefore, medical providers caring for postpartum women should be educated about continued monitoring of signs and symptoms and prompt management of these women in a timely fashion. Evaluation and management should be performed in a stepwise fashion and may require a multidisciplinary approach that considers predelivery risk factors, time of onset, associated signs/symptoms, and results of selective laboratory and imaging findings. The objective of this review is to increase awareness and to provide a stepwise approach toward the diagnosis and management of women with persistent and/or new-onset hypertension-preeclampsia postpartum period.

  5. Implication of Tumor Necrosis Factor - Alpha in Preeclampsia

    Directory of Open Access Journals (Sweden)

    Dan MIHU

    2008-12-01

    Full Text Available Introduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of preeclampsia. Material and Method: A transversal study was performed in three groups of patients: non-pregnant patients, patients with normal pregnancies in the third trimester, patients with preeclampsia. Serum TNF-α levels were determined using the immunometric sandwich EIA method.Results: The results obtained confirm a significant increase (p<0.01 in circulating TNF-α levels in the last trimester of pregnancy, compared to the non-pregnant status. Significantly increased serum TNF-α concentrations (p<0.001 were also found in pregnant patients with preeclampsia, compared to normotensive pregnant women. Conclusion: This proinflammatory cytokine can be a potential marker of the severity of the preeclamptic syndrome, without being an indicator of the fetal status at birth.

  6. Preeclampsia – will Orphan Drug Status facilitate innovative biological therapies?

    Directory of Open Access Journals (Sweden)

    Sinuhe eHahn

    2015-02-01

    Full Text Available It is generally accepted that development of novel therapies to treat pregnancy-relates disorders, such as preeclampsia, is hampered to the paucity of research funding. Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder, exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells. As these projects are being carried out by small biotech enterprises, the question arises of how they are able to fund such undertakings. A novel strategy adopted by two of these companies is that they successfully petitioned US and EU agencies in order that preeclampsia be accepted in the register of rare or orphan diseases. This provides a number of benefits including market exclusivity, assistance with clinical trials and dedicated funding schemes. Other strategies to supplement meager research funds, especially to test novel approaches, could be crowdfunding, a venture which relies on intimate interaction with advocacy groups. In other words, preeclampsia meets Facebook. Perhaps similar strategies can be adopted to examine novel therapies targeting either the imbalance in angiogenic growth factors, complement activation, reduced levels of placenta protein 13 or excessive neutrophil activation evident in preeclampsia.

  7. Poor Health-related Quality of Life After Severe Preeclampsia

    NARCIS (Netherlands)

    Hoedjes, Meeke; Berks, Durk; Vogel, Ineke; Franx, Arie; Duvekot, Johannes J.; Steegers, Eric A. P.; Raat, Hein

    2011-01-01

    Background: Preeclampsia is a major complication of pregnancy associated with increased maternal morbidity and mortality, and adverse birth outcomes. The objective of this study was to describe changes in all domains of health-related quality of life between 6 and 12 weeks postpartum after mild and

  8. [Serum uric acid levels and risk of developing preeclampsia].

    Science.gov (United States)

    Corominas, Ana I; Balconi, Silvia M; Palermo, Mario; Maskin, Bernardo; Damiano, Alicia E

    2014-01-01

    It is well known that preeclampsia is associated to high uric acid levels, but the clinical assessment of this relationship is still under consideration. Our research was to evaluate if periodic doses of uric acid during pregnancy might help to identify a high risk group prior to the onset of preeclampsia. We conducted a retrospective investigation in 79 primary gestates with normal blood pressure and 79 women with preeclampsia who were assisted at Hospital Nacional Posadas during 2010. Serum uric acid levels, creatininemia, uremia, and proteinuria data from the clinical records of the pregnant women were considered. Uric acid levels were similar in both groups during the first half of gestation. However, as of the 20th week, uric acid increased 1.5-times in preeclamptic women with no changes in creatinine and urea, confirming that these patients had no renal complications. Furthermore, we noted that higher levels of uric acid correlated with low birth weight. We also observed that pregnant women with a family history of hypertension were more likely to develop this condition. Moreover, we did not find a direct relationship with the fetal sex or the appearance of clinical symptoms. The analytical evidence suggests that changes in uric acid concentrations may be due to metabolic alterations at the initial stages of preeclampsia. Therefore, we propose that monitoring levels of uric acid during pregnancy might contribute to the early control of this condition.

  9. COSTE DE LA DIARREA ASOCIADA A CLOSTRIDIUM DIFFICILE EN ESPAÑA

    Directory of Open Access Journals (Sweden)

    Ángel Asensio

    2013-01-01

    Full Text Available Fundamentos: No se dispone de estudios adecuados del coste de las diarreas asociadas a Clostridium difficile (DACD en España. El objetivo del estudio es estimar el coste de las DACD para el Sistema Nacional de Salud (SNS. Métodos: Se realizó un modelo económico para calcular el coste por episodio de DACD (por antibióticos, prolongación del ingreso hospitalario, procedimientos quirúrgicos, medidas de control de la infección, recurrencias de las infecciones tratadas y el coste anual de la DACD. El uso de recursos en la práctica clínica se obtuvo mediante un panel Delphi de clínicos españoles con experiencia en la DACD y los costes unitarios (€ 2012 de fuentes españolas. Resultados: Se estimó que anualmente se produjeron 7.601 episodios de DACD en España (incidencia de 17,1 episodios/año/10.000 altas hospitalarias con un gasto anual para el SNS de 32.157.093 €. Coste por episodio de DACD: 3.901 € (infección inicial, 4.875 € (primera recurrencia y 5.916 € (segunda recurrencia. Coste total de las recurrencias: 10.426.750 € anuales. El 95,6% del gasto se debería a la prolongación de la duración de la estancia hospitalaria, el 0,5% a tratamientos antibióticos, el 2,8% a intervenciones quirúrgicas y el 1,1% a las medidas de control de la infección. Los resultados del estudio fueron sensibles a la incidencia y tasa de letalidad de la DACD en España y a la duración de la prolongación de la duración de la estancia hospitalaria debida a la DACD. Conclusiones: Según este estudio, el gasto asociado a la DACD se debe fundamentalmente a la prolongación de los ingresos hospitalarios y tiene un gran impacto económico en el SNS.

  10. Amenazas naturales asociadas al ascenso del nivel del mar en Caribe Colombiano

    Directory of Open Access Journals (Sweden)

    Robertson Kim Gregory

    2003-01-01

    Full Text Available Se presentan los resultados de recientes investigaciones sobre el impacto del ascenso del nivel del mar en la Costa Caribe colombiana, bases para el primer informe de Colombia a la Convención Internacional de Cambio Climático, adelantado en convenio con elIDE..-.1f. Con base en el estudio de las geoformas litorales, los procesos dinámicos asociadosy su evolución reciente, se evaluó la amenaza por inundación y erosión asociada al actual ascenso del nivel del mar, proyectado por IP(C (panel Intergubemamcntal de Expertos de Cambio Climático en un metro pata el año 2100. A partir de la interpretación de imágenes de satélite y fotografias aéreas, apoyada en información secundaria y verificación de campo, se identificaron 15 unidades geomorfológicas básicas de origen estructural, fluvial y marino. Con base las características geomorfológicas y criterios de resiliencia frente a la acción del oleaje y la inundación litoral, se generó un modelo morfodinámico que pronostica el impacto del ascenso del nivel marino para el litoral Caribe colombiano. De acuerdo con este análisis, se estima que las unidades geomorfológicas recientes desarrolladas durante los últimos 2.500 años podrían ser reactivadas por el actual ascenso del nivel del mar, afectando numerosos centros urbanos tales como Cartagena, Santa Marta, Puerto Colombia y Turbo y actividades económicas de-importancia como el comercio portuario y el turismo. Para los 1.819 Km. de línea de costa del Caribe Colombiano, se estima que el 33.7% presenta alta susceptibilidad a la erosión marina, representado por geoformas que presentan grari fragilidad ante los procesos erosivos. En la linea de costa restante, 31,2% presenta susceptibilidad mec!ia y 35.1% susceptibilidad baja y muy baja, en una linea de costa caracterizada por geoformas con fragilidad y mecanismos de resiliencia variables. Por inundación, se pronostica que 1192 Km2 de costa baja serán anegados, 2331 Km2 sufrir

  11. Estudio de variables asociadas a la psicoterapia grupal en los procesos de duelo patológico.

    Directory of Open Access Journals (Sweden)

    Juan Díaz Curiel

    2011-01-01

    Full Text Available Se estudian variables asociadas al proceso terapéutico grupal (10 sesiones de 75 minutos de 24 sujetos adultos (23 mujeres y 1 varón distribuídos en cuatro grupos de terapia durante los años 2007-2010 con diagnóstico de duelo complicado (DC. El DC se evalúa a través de la Escala de Prigerson (punto de corte más de 24 (Prigerson, 1995, Traducción Española Olmeda y García, 2006. Los pacientes pertenecen al Equipo de Salud (ESM de Vallecas Villa y acuden remitidos por el médico de Atención Primaria para evaluar y tratar síntomas compatibles con duelo complicado. En otros casos el DC se detecta en las primeras entrevistas de evaluación, o bien a lo largo del tratamiento psiquiátrico o psicoterapéutico por los profesionales del ESM. Una vez finalizado el tratamiento grupal (TG se vuelve a pasar La Escala de Prigerson obteniendo como resultado diferencias significativas en las puntuaciones antes y después del tratamiento, indicador de que el duelo complicado mejora significativamente en los sujetos que han participado en el tratamiento grupal.

  12. MATERNAL AND FETAL OUTCOME IN PRE-ECLAMPSIA AND ECLAMPSIA

    Directory of Open Access Journals (Sweden)

    Sipra

    2015-11-01

    Full Text Available BACKGROUND Pre-Eclampsia and Eclampsia are the leading causes of maternal and perinatal morbidity and mortality worldwide. In developed countries, much lower incidences have been achieved through aggressive screening and management of Pre-Eclampsia. In developing countries like India, there is a wide gap in quality of health care in cities and rural area. The present study was done to evaluate the incidence of hypertensive disorders and maternal and fetal outcome in a tertiary care centre catering to poor people of Bihar, Bengal and neighboring country, Nepal. MATERIALS AND METHODS This is an observational descriptive study. After obtaining institutional ethical committee approval and informed consent from patients, all the patients presenting to our institution for delivery with Pre-Eclampsia and Eclampsia were included in the study. Socio-economic status, frequency of ANC, age, parity and period of gestation were recorded. Investigations included complete blood count, urinary protein, coagulation profile, liver function tests and kidney function tests. Mode of conduct of delivery and maternal and fetal outcome were thoroughly recorded and described. Data was presented in the form of n (%. RESULTS 64.28% cases with Pre-Eclampsia and 95.12% cases with Eclampsia were from low socio-economic status. 95.12% cases with Eclampsia and 67.5% cases with Pre-Eclampsia had no ANC throughout the pregnancy. Most of the patients were in the age group of 20-25 years. 86.11% cases with Eclampsia and 66.68% with Pre-Eclampsia were primigravida. Most of the patients presented with 37 weeks of gestation. 54.76% Pre-Eclampsia cases and 58.94% Eclampsia delivered by L.S.C.S. Pulmonary edema and acute renal failure were the most common complications. Maternal mortality was 25.60% in Eclampsia cases. The most common cause of maternal mortality was pulmonary edema. Incidence of IUD+ stillbirth was 16.66% in Pre-Eclampsia cases and 34.14% in Eclampsia cases. Overall

  13. Evaluación intra e interobservador en el diagnóstico radiográfico de fracturas asociadas a la ingesta de bifosfonatos [Intraobserver and interobserver evaluation in the radiological diagnosis of bisphosphonate-related fractures

    OpenAIRE

    Guido Carabelli; Jorge Daniel Barla; Danilo Eric Taype; Carlos Federico Sancineto

    2015-01-01

    Objetivo Determinar la utilidad de la evaluación radiográfica, como único elemento, en el diagnóstico de las fracturas asociadas a la ingesta de bifosfonatos.  Material y método Del año 2006 al 2011, se evaluaron las radiografías de pacientes con fracturas subtrocantéricas y diafisarias de fémur, excluyendo fracturas de fémur proximal, distal, patológicas y  pacientes pediátricos. Se obtuvieron radiografías de 167 pacientes con 169 fracturas (2 bilaterales), siendo 109 mediodi...

  14. Aplicación para la grabación, obtención y reproducción de información asociada a etiquetas RFID sobre Windows Mobile 2005 en C# 2.0

    OpenAIRE

    Comas Fernández, Joan

    2009-01-01

    El objetivo principal de la aplicación es la de permitir a un usuario grabar un mensaje oral vinculado a una etiqueta RFID (1) y obtener la posible información asociada a esta etiqueta desde un sistema global, que haya podido ser introducida por un fabricante, reproduciéndola mediante un software existente de Text-To-Speech (2) (3), sobre una plataforma móvil PDA con Windows Mobile 5.0. Esta nueva herramienta está pensada para mejorar la calidad de vida y la autonomía de las personas con p...

  15. EVALUACIÓN DE LAS PÉRDIDAS ECONÓMICAS POR EVENTOS DE FALLA REPRODUCTIVA ASOCIADAS A BRUCELOSIS BOVINA EN HEMBRAS Y EXPLOTACIONES DE LA CUENCA LECHERA DE TIZAYUCA, HIDALGO, MÉXICO

    OpenAIRE

    Víctor Manuel Xolalpa Campos; Miguel Pérez Ruano; Alejandro Córdova Izquierdo

    2010-01-01

    Con el objetivo de determinar las pérdidas financieras asociadas a brucelosis, se estudiaron 20 unidades de producción lechera (UPL) de la Cuenca de Tizayuca, Hidalgo, México, que aplicaban diferentes subprogramas de control de la enfermedad. Para estimar las pérdidas se utilizaron los eventos que se relacionaron significativamente con la brucelosis (abortos, nacimientos prematuros, tumores uterinos, celos perdidos y becerros nacidos muertos). Las pérdidas más altas por eventos de falla repro...

  16. TO ASSESS THE MAGNITUDE OF OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE IN PREECLAMPSIA

    Directory of Open Access Journals (Sweden)

    Richa Pramod Priyamvada

    2016-07-01

    Full Text Available Preeclampsia is a multifactorial disease. Recent studies show that free radical induced endothelial injury may be a factor in pathogenesis of preeclampsia and that a biochemical imbalance occurs with an increase of oxidative stress, lipoperoxidation and deficient antioxidants. AIMS AND OBJECTIVES To evaluate parameters of oxidative stress and antioxidant defense in preeclampsia and thereby find any aetiological correlation. MATERIALS AND METHODS Study was carried on pregnant and non-pregnant women placed in four groups. This study was done to assess Malondialdehyde (MDA, as marker of oxidative stress and Total Antioxidant Capacity (TAC measured by Ferric Reducing Ability of Plasma (FRAP in normal pregnancy and preeclampsia and comparing with non-pregnant females. RESULTS Study shows rise in MDA level highest in severe preeclampsia (192.8 followed by mild preeclampsia (151.8 than in normal pregnancy (105.9, and non-pregnant (95.8 showing significant increase in levels of MDA (p<0.0001 in preeclamptic patients. TAC measured by FRAP significantly highest in severe preeclampsia (1725.6 followed by mild preeclampsia (1507 than in normal pregnancy (1203.3 and although there was increase in TAC in normal pregnant compared to non-pregnant (1173.7, increase was statistically insignificant. CONCLUSION Preeclampsia shows markedly increased oxidative stress as evidenced by significantly increased levels of malondialdehyde. There was strong correlation between total antioxidant capacity with severity of preeclampsia.

  17. Cluster analysis to estimate the risk of preeclampsia in the high-risk Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study

    Science.gov (United States)

    Marttinen, Pekka; Gillberg, Jussi; Lokki, A. Inkeri; Majander, Kerttu; Ordén, Maija-Riitta; Taipale, Pekka; Pesonen, Anukatriina; Räikkönen, Katri; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele

    2017-01-01

    Objectives Preeclampsia is divided into early-onset (delivery before 34 weeks of gestation) and late-onset (delivery at or after 34 weeks) subtypes, which may rise from different etiopathogenic backgrounds. Early-onset disease is associated with placental dysfunction. Late-onset disease develops predominantly due to metabolic disturbances, obesity, diabetes, lipid dysfunction, and inflammation, which affect endothelial function. Our aim was to use cluster analysis to investigate clinical factors predicting the onset and severity of preeclampsia in a cohort of women with known clinical risk factors. Methods We recruited 903 pregnant women with risk factors for preeclampsia at gestational weeks 12+0–13+6. Each individual outcome diagnosis was independently verified from medical records. We applied a Bayesian clustering algorithm to classify the study participants to clusters based on their particular risk factor combination. For each cluster, we computed the risk ratio of each disease outcome, relative to the risk in the general population. Results The risk of preeclampsia increased exponentially with respect to the number of risk factors. Our analysis revealed 25 number of clusters. Preeclampsia in a previous pregnancy (n = 138) increased the risk of preeclampsia 8.1 fold (95% confidence interval (CI) 5.7–11.2) compared to a general population of pregnant women. Having a small for gestational age infant (n = 57) in a previous pregnancy increased the risk of early-onset preeclampsia 17.5 fold (95%CI 2.1–60.5). Cluster of those two risk factors together (n = 21) increased the risk of severe preeclampsia to 23.8-fold (95%CI 5.1–60.6), intermediate onset (delivery between 34+0–36+6 weeks of gestation) to 25.1-fold (95%CI 3.1–79.9) and preterm preeclampsia (delivery before 37+0 weeks of gestation) to 16.4-fold (95%CI 2.0–52.4). Body mass index over 30 kg/m2 (n = 228) as a sole risk factor increased the risk of preeclampsia to 2.1-fold (95%CI 1.1–3

  18. The Relationship Between Blood Lead Level and Preeclampsia

    Science.gov (United States)

    Bayat, Fatemeh; Akbari, Sedigheh Amir Ali; Dabirioskoei, Atousa; Nasiri, Malihe; Mellati, Aliosat

    2016-01-01

    Introduction Lead is a heavy metal to which people are commonly exposed. One of the possible mechanisms of tissue damages caused by this toxic metal is oxidative stress, which in turn may cause numerous pregnancy complications such as preeclampsia. The present study was conducted to determine the relationship between maternal Blood Lead Level (BLL) and preeclampsia. Methods The present case-control study was conducted on 158 pregnant women admitted to a hospital in Zanjan, Iran, from August 2015 to March 2016. To measure their BLL, 1.5 cc of blood was drawn from each participant. The demographic and obstetric details of the patients were recorded in a form. The potentiometric method was used to test the samples. The data obtained were analyzed by SPSS version 22, using Mann-Whitney U test, the Chi square, independent-samples t-test, Pearson product-moment correlation, and simple linear regression analysis. Results The mean BLL was 6.24±1.74 μg/dl in the control group and 8.04±3.4 μg/dl in the preeclampsia group. The two groups were matching in terms of the mother’s age and education and the household income. A significant relationship was observed between BLL and preeclampsia (p=0.028), as per every unit of increase (1 μg/dl) in BLL, systolic blood pressure increased by 0.014 mm Hg and diastolic blood pressure by 0.013 mm Hg (p=0.004). Conclusion The results obtained suggest a relationship between BLL and preeclampsia. Global health measures should be taken to remove the exposure to lead so as to reduce its absorption by pregnant women. PMID:28163864

  19. Diagnosis and management of pre-eclampsia: an update

    Directory of Open Access Journals (Sweden)

    Judi A Turner

    2010-09-01

    Full Text Available Judi A TurnerDepartment of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USAAbstract: Pre-eclampsia is a significant, multifactorial, multiorgan disease affecting 5%–8% of all pregnancies in the US where it is the third leading cause of maternal mortality. Despite improvements in the diagnosis and management of pre-eclampsia, severe complications can occur in both the mother and the fetus, and there is no effective method of prevention. Early detection and identification of pregnant women most at risk of developing the disease have proven challenging, but recent efforts combining biochemical and biophysical markers are promising. Efforts at prevention of pre-eclampsia with aspirin and calcium have had limited success, but research on modifiable risk factors, such as obesity surgery, are encouraging. Obstetric management of severe pre-eclampsia focuses on medical management of blood pressure and prevention of seizures using magnesium sulfate, but the ultimate cure remains delivery of the fetus and placenta. Timing of delivery depends on several factors, including gestational age, fetal lung maturity, and most importantly, disease severity. Anesthetic management includes regional anesthesia with careful evaluation of the patient’s airway, volume status, and coagulation status to reduce morbidity and mortality. The potential complications of general anesthesia, including intracranial hemorrhage, in these patients make regional anesthesia the preferred choice in many cases. Nevertheless, it is important to be aware of the contraindications to neuraxial anesthesia and to prepare always for the possibility of encountering a difficult airway.Keywords: pre-eclampsia, diagnosis, risk factors, complications, management, anesthesia, prevention

  20. Disertación endocrina de la preeclampsia y propuesta de una hipótesis Endocrine dissertation on preeclampsia and proposal of a hypothesis

    Directory of Open Access Journals (Sweden)

    Bernardo Agudelo Jaramillo

    1992-01-01

    Full Text Available

    Se propone que la facies androgenizada en las embarazadas podría servir como elemento clínico para la búsqueda de la preeclampsia, con el fin de lograr un enfoque preventivo. El balance de las prostaglandinas vasodilatadoras y vasoconstrictoras es, en último término, responsable del control de la presión arterial en la gestante. Para ello se debe lograr un adecuado equilibrio en la producción de hormonas gestacionales; de ellas parece ser fundamental la dihidroprogesterona que se obtiene a través de la acción de la enzima 5-alfa reductasa. En el metabolismo de los andrógenos esta enzima cumple un papel único al transformar los andrógenos circulantes en la hormona trófica, la dihidrotestosterona. La hipótesis propone que la utilización androgénica de la enzima 5-alfa reductasa durante la gestación alteraría la producción de dihidroprogesterona con lo cual crearía un desequilibrio entre las diferentes hormonas y, finalmente, entre las prostaglandinas.

    The hypothesis that an androgenized facies In a pregnant woman could serve as a clinical clue for the search of preeclampsia, making It possible to apply a preventive approach is proposed. The balance between dilator and constrictor prostaglandins controls blood pressure during pregnancy; to keep such a balance an adequate equilibrium in the production of hormones, particularly dihydroprogesterone (DHP, is necessary. DHP is obtained through the action of 5-alpha reductase, which in androgen metabolism has the unique role of transforming circulating androgens into the trophic hormone dihydrotestosterone. The hypothesis proposes that androgenic utilization of 5- alpha reductase during pregnancy could alter the production of DHP I generating a lack of equilibrium among the various hormones, prostaglandins included.

  1. Medición de la eficiencia técnica relativa de las fincas asociadas a Coounión en Guasca Cundinamarca

    Directory of Open Access Journals (Sweden)

    Wilson Oviedo G.

    2011-05-01

    Full Text Available Objetivo. Medir la eficiencia técnica relativa en las fincas asociadas a la cooperativa COOUNIÓN mediante Data Envelopment Analysis DEA (Análisis Envolvente de Datos. Materiales y métodos. Se tomaron como muestra las doce fincas asociadas a la Cooperativa Coounión en el municipio de Guasca (Cundinamarca. La información se obtuvo durante el período comprendido entre el 1º de junio del 2008 y el 31 de mayo del 2009. Los datos se estructuraron en seis variables, de las cuales se plantean dos modelos, ambos con cuatro variables y que están orientados a las entradas con rendimientos constantes a escala (CRS. El primer modelo consta de tres entradas: nutrición, mantenimiento, ordeño, y una salida: leche; mientras que el segundo modelo cuenta con dos entradas: nutrición, mantenimiento y dos salidas: carne, crías. Resultados. De las doce fincas solo una presentó, la mejor eficiencia tanto en el modelo 1 como en el modelo 2. Por esta razón, se determinaron las mejores prácticas de esta finca con el fin de replicarlas en las demás. Conclusiones. Aplicar la metodología DEA en las fincas ganaderas es viable porque permite enfocarse principalmente en aquellas variables que son controlables por el ganadero como los insumos. Por consiguiente, la evaluación de la eficiencia técnica relativa se desarrolló orientada a estos; así se demostró que las fincas pueden mantener sus niveles de producción actuales haciendo reducciones significativas en sus costos.

  2. Cardiovascular risk factors in women 10 years post early preeclampsia: the Preeclampsia Risk EValuation in FEMales study (PREVFEM).

    NARCIS (Netherlands)

    Drost, J.T.; Arpaci, G.; Ottervanger, J.P.; Boer, M.J. de; Eyck, J. van; Schouw, Y.T. van der; Maas, A.H.E.M.

    2012-01-01

    Introduction: Preeclampsia is a complication of pregnancy and a known risk factor for cardiovascular disease (CVD) later in a women's life. The best approach for prevention of CVD in affected young women is yet unclear. We sought to investigate the prevalence of cardiovascular risk factors in women

  3. Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia : Cause or consequence of preeclampsia

    NARCIS (Netherlands)

    Prins, J.R.; van der Hoorn, M L P; Keijser, R; Ris-Stalpers, C; van Beelen, E; Afink, G B; Claas, F H J; van der Post, J A M; Scherjon, S A

    2016-01-01

    The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines i

  4. Ocorrência de hematoma peridural após anestesia geral associada à analgesia pós-operatória com cateter peridural em paciente em uso de heparina de baixo peso molecular: relato de caso Ocurrencia de hematoma postanestesia general asociada a analgesia postoperatoria con cateter peridural en paciente que usa heparina de bajo peso molecular: relato de caso Epidural hematoma after general anesthesia associated with postoperative analgesia with epidural catheter in patient using low molecular weight heparin: case report

    Directory of Open Access Journals (Sweden)

    Ranger Cavalcante da Silva

    2006-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apresentar um caso de paciente com hematoma peridural, na vigência do uso de cateter peridural e heparina de baixo peso molecular, seu quadro clínico e tratamento. RELATO DO CASO: Paciente do sexo feminino, 75 anos, submetida à fixação de coluna lombar por via anterior, que desenvolveu no pós-operatório quadro clínico de paralisia progressiva nos membros inferiores, com perda de sensibilidade, sem apresentar dor radicular intensa. O tratamento foi descompressão medular imediata, com drenagem e limpeza cirúrgica de hematoma peridural, que se estendia da quinta até a décima vértebra torácica. Após a drenagem do hematoma a paciente recuperou gradualmente a força nos membros inferiores, recebeu alta em 10 dias com quadro de disfunção esfincteriana. Após três meses o quadro regrediu e não houve seqüela neurológica definitiva. CONCLUSÕES: O rápido diagnóstico com intervenção cirúrgica precoce é o tratamento mais eficaz para redução de lesão neurológica, em pacientes que desenvolvem hematoma peridural no pós-operatório. A utilização de heparina de baixo peso molecular, na vigência do uso de cateter peridural, exige a adesão estrita a protocolos estabelecidos, para que se reduzam os riscos do desenvolvimento de hematoma peridural.JUSTIFICATIVA Y OBJETIVOS: presentar el caso de una paciente con hematoma peridural, con uso actual de catéter peridural y heparina de bajo peso molecular, su cuadro clínico y tratamiento. RELATO DEL CASO: Paciente de 75 años, sometida a la fijación de columna lumbar por vía anterior, que desarrolló en el postoperatorio un cuadro clínico de parálisis progresiva en los miembros inferiores, con pérdida de la sensibilidad, sin presentar dolor radicular intenso. El tratamiento fue descompresión medular inmediata, con drenaje y limpieza quirúrgica de un hematoma peridural, que se extendía desde la quinta hasta la décima vértebra toráxica. Después del

  5. INTERACCION DE ESPECIES ACTIVAS DEL OXIGENO Y RADICALES LIBRES CON ENZIMAS.

    OpenAIRE

    ASPEE LAMAS, ALEXIS

    2000-01-01

    En la presente Tesis, se estudió la inactivacián de enzimas por especies radicalarias, y la quimioluminiscencia asociada a la oxidación de aminoácidos y proteínas. En relación con la inactivación radicalaria de enzimas, el estudio se centró principalmente 178p.

  6. Fracturas psicosociales asociadas a la prejubilación

    Directory of Open Access Journals (Sweden)

    Héctor Tejón Sáez

    2010-10-01

    Full Text Available Este artículo analiza, de una manera introductoria, el concepto de prejubilación. A partir de una perspectiva psicosocial, se señalan los problemas derivados de esa expulsión prematura del mercado laboral que padecen personas mayores de cincuenta y cinco años. Son trabajadores cualificados, con una experiencia acumulada que, para muchas empresas, deja de ser un valor añadido y se convierte en una carga. La identificación con el trabajo y la percepción de la nueva situación son los factores principales que determinan la adaptación positiva o negativa de esas personas prejubiladas, en un mundo global donde los antiguos esquemas de sentido se han derrumbado.

  7. Luxación posterior de codo asociada a traslocación radiocubital proximal

    OpenAIRE

    Gascó Gómez, J.; Gomar Sancho, Francisco; Gascó Adrién, J.

    2004-01-01

    La luxación de codo en los niños es poco frecuente y normalmente suele ir asociada a fracturas. La luxación asociada a traslocación radiocubital proximal es excepcional y tan sólo nueve casos se han publicado. Se presenta el caso de un niño de 9 años que tras una caída casual presentó luxación de codo asociada a traslocación radiocubital. Esta lesión fue descrita por primera vez por MacSween en 1978. El mecanismo de producción más frecuente pude ser una caída sobre la mano y antebrazo en p...

  8. Dermatitis asociada a incontinencia en adultos: un problema sin definición, revisión sistemática

    Directory of Open Access Journals (Sweden)

    Renata Virginia González-Consuegra

    2015-04-01

    Full Text Available Antecedentes. La prevalencia de la dermatitis, asociada a incontinencia urinaria, fecal o mixta, está entre 5.6% y 50%, con una tasa de incidencia entre 3.4% y 25%. Estas lesiones infravaloradas no se afrontan adecuadamente por desconocimiento de sus implicaciones y su cuidado, lo que exige conocer la producción científica al respecto, estandarizando estos procesos en personas con riesgo de padecerla. Objetivo. Describir la producción científica disponible que aborde la gestión de los cuidados de las personas adultos mayores que presentan dermatitis asociada a incontinencia urinaria, fecal o mixta. Materiales y métodos. Se llevó a cabo una revisión sistemática de literatura científica en las bases de datos Ovid Nursing, SciELO, Biblioteca Virtual en Salud, Pubmed, Scopus, EBSCOhost, ScienceDirect, Cuiden, JSTOR y Springer Journal, sin fecha límite, en cualquier idioma. Se valoraron los artículos mediante el sistema GRADE. Resultados. Se encontraron 45 artículos, en su mayoría de Norteamérica y Europa, de los cuales un 15.22% abordan temas de epidemiología, 15.22% tratan sobre factores de riesgo, 32.61% sobre prevención primaria, 8.70% sobre diagnóstico, 17.39%, tratamiento, 4.35%, medición del problema y 6.52%, rehabilitación. La metodología en el 53% de los artículos correspondió a ensayos clínicos. Conclusión. La toma de decisiones con respecto al diagnóstico, la prevención y el tratamiento de la dermatitis asociada a incontinencia, deben apoyarse en los múltiples factores de riesgo y etiológicos de las lesiones de piel que puedan tener relación con la dependencia, los cuales, sin lugar a dudas, orientarán el mecanismo de producción y así, laintervención de la enfermedad.

  9. Angiogenic factors in superimposed preeclampsia: a longitudinal study of women with chronic hypertension during pregnancy.

    Science.gov (United States)

    Perni, Uma; Sison, Cristina; Sharma, Vijay; Helseth, Geri; Hawfield, Amret; Suthanthiran, Manikkam; August, Phyllis

    2012-03-01

    Imbalances in circulating angiogenic factors contribute to the pathogenesis of preeclampsia. To characterize levels of angiogenic factors in pregnant women with chronic hypertension, we prospectively followed 109 women and measured soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor at 12, 20, 28, and 36 weeks' gestation and postpartum. Superimposed preeclampsia developed in 37 (34%) and was early onset (hypertension. We conclude that alterations in angiogenic factors are detectable before and at the time of clinical diagnosis of early onset superimposed preeclampsia, whereas alterations were observed only at the time of diagnosis in women with late-onset superimposed preeclampsia. Longitudinal measurements of angiogenic factors may help anticipate early onset superimposed preeclampsia and facilitate diagnosis of superimposed preeclampsia in women with chronic hypertension.

  10. Maternal and fetal human leukocyte antigen class Ia and II alleles in severe preeclampsia and eclampsia

    DEFF Research Database (Denmark)

    Emmery, J.; Hachmon, R.; Pyo, C. W.;

    2016-01-01

    and -DPB1) alleles and the risk of developing severe preeclampsia/eclampsia were investigated in a detailed and large-scale study. In total, 259 women diagnosed with severe preeclampsia or eclampsia and 260 matched control women with no preeclampsia, together with their neonates, were included in the study....... HLA genotyping for mothers and neonates was performed using next-generation sequencing. The HLA-DPB1*04:01:01G allele was significantly more frequent (Pc=0.044) among women diagnosed with severe preeclampsia/eclampsia compared with controls, and the DQA1*01:02:01G allele frequency was significantly...... lower (Pc=0.042) among newborns born by women with severe preeclampsia/eclampsia compared with controls. In mothers with severe preeclampsia/eclampsia, homozygosity was significantly more common compared with controls at the HLA-DPB1 locus (Pc=0.0028). Although the current large study shows some...

  11. Pre-Eclampsia Increases the Risk of Postpartum Haemorrhage: A Nationwide Cohort Study in The Netherlands

    OpenAIRE

    Joost F von Schmidt auf Altenstadt; Hukkelhoven, Chantal W. P. M.; Jos van Roosmalen; Bloemenkamp, Kitty W. M.

    2013-01-01

    BACKGROUND: Postpartum haemorrhage is a leading cause of maternal morbidity and mortality worldwide. Identifying risk indicators for postpartum haemorrhage is crucial to predict this life threatening condition. Another major contributor to maternal morbidity and mortality is pre-eclampsia. Previous studies show conflicting results in the association between pre-eclampsia and postpartum haemorrhage. The primary objective of this study was to investigate the association between pre-eclampsia an...

  12. Community perceptions of pre-eclampsia and eclampsia in Ogun State, Nigeria: a qualitative study

    OpenAIRE

    Akeju, DO; Vidler, M; Oladapo, OT; Sawchuck, D.; Qureshi, R; von Dadelszen, P; Adetoro, OO; Dada, OA; CLIP Nigeria Feasibility Working Group,

    2016-01-01

    Background Pre-eclampsia is a complication of pregnancy responsible for high rates of morbidity and mortality, particularly in sub-Saharan Africa. When undetected or poorly managed, it may progress to eclampsia which further worsens the prognosis. While most studies examining pre-eclampsia have used a bio-medical model, this study recognizes the role of the socio-cultural environment, in order to understand perceptions of pre-eclampsia within the community. Methods The study was conducted in ...

  13. Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study

    OpenAIRE

    2009-01-01

    Objective: To investigate whether pre-eclampsia is more common in first pregnancies solely because fewer affected women, who presumably have a higher risk of recurrence, go on to have subsequent pregnancies. Design: Prospective cohort study. Setting: Swedish Medical Birth Register. Participants: 763 795 primiparous mothers who had their first births in Sweden, 1987-2004. Main outcome measures: Pre-eclampsia. Results: The risk of pre-eclampsia was 4.1% in the first pregnancy and 1.7% in later ...

  14. On the pathology of preeclampsia: genetic variants, complement dysregulation and angiogenesis

    OpenAIRE

    2013-01-01

    Preeclampsia is a pregnancy-specific condition that originates in the placenta. Despite decades of research, its pathogenesis remains largely unknown. However, several risk factors for preeclampsia have been identified, including a (family) history of preeclampsia, autoimmune disease and conditions associated with endothelial damage, including hypertension, diabetes mellitus and preexistent renal disease. This thesis aims to further investigate through which mechanisms these risk factors incr...

  15. Spontaneous Hepatic Rupture Associated with Preeclampsia: Treatment with Hepatic Artery Embolization

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Seung Boo; Goo, Dong Erk; Chang, Yun Woo; Kim, Yong Jae; Hwang, In Cheol; Han, Hyo Sang; Yoon, Jong Hyun; Lee, Tae Il [Soonchunhyang University Hospital, Gumi (Korea, Republic of)

    2010-02-15

    Spontaneous rupture of the liver due to preeclampsia is a rare condition of pregnant women, and it can be very dangerous if not treated. We report here on a case of successfully treating spontaneous liver rupture associated with preeclampsia by performing transcatheter hepatic arterial embolization. A 41-year-old woman with spontaneous rupture of the liver associated with preeclampsia was treated by hepatic arterial embolization

  16. Family history of hypertension increases risk of preeclampsia in pregnant women: a case-control study

    OpenAIRE

    2016-01-01

    Background Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortalities worldwide. Despite extensive research, the underlying cause of preeclampsia remains poorly understood. This study aimed to offer compelling evidence on the important risk factors of preeclampsia in Amhara region, Ethiopia. Methods A case control study was conducted in public health facilities of Bahir Dar city from September 2014 to January 2015. A total of 453 (151 cases and 302 co...

  17. Short-term outcome of patients with preeclampsia

    Directory of Open Access Journals (Sweden)

    Koual M

    2013-04-01

    Full Text Available Meriem Koual, Hind Abbou, Marie Carbonnel, Olivier Picone, Jean-Marc Ayoubi Department of Gynecology and Obstetrics, Hôpital Foch, Suresnes, France Introduction: Preeclampsia constitutes a cause of increased mortality in mothers and fetuses. Screening for promoting factors is essential for adequate prevention in the event of any subsequent pregnancy, and for the adequate follow-up of concerned patients. The aim of the present study was to evaluate the short-term outcome of patients with preeclampsia and to identify possible new factors predisposing them to the disease. Methods: One hundred fifty-five patients having experienced preeclampsia between 2005 and 2010 from the Gynecology and Obstetrics Department of the Foch Hospital (Suresnes, France were included in the study. All patients had undergone close clinical and standard biological follow-up immediately postpartum and then 3 months later with a reference practitioner. In severe cases, further investigation was carried out by full etiological examination with an assessment of both autoimmune and thrombophilic status. Results: Obesity and gestational diabetes were observed to be major risk factors for preeclampsia, which were found in 46% and 15% of the cases, respectively. The etiological assessment showed abnormalities in 11% of the patients. Impaired thrombophilia was found in 3% of the patients, impaired autoimmune status in 4%, a combination of both abnormalities in only 1% of the patients, and detection of renal abnormalities in 3% of the patients were observed. In the immediate postpartum period, 66% of patients had maintained elevated blood pressure levels, and 66% had proteinuria > 0.3 g/24 hours. At the 3-month postpartum assessment, persisting arterial hypertension was found in 16% of the patients, requiring continuation of antihypertensive therapy, and 22% of the patients had proteinuria over the accepted threshold (0.15 g/24 hours. Conclusion: Patients with preeclampsia have

  18. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?*

    Institute of Scientific and Technical Information of China (English)

    Jing Ge; Jun Wang; Dan Xue; Zhengsheng Zhu; Zhenyu Chen; Xiaoqiu Li; Dongfeng Su; Juan Du

    2013-01-01

    Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein ex-pressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preec-lampsia in pregnant rats.

  19. The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

    Directory of Open Access Journals (Sweden)

    Ji-peng Wan

    Full Text Available BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP rs11646213 was genotyped by polymerase chain reaction (PCR and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76. Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03 and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13. Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.

  20. Alteraciones cerebrales en enfermedad hipertensiva asociada a embarazo

    OpenAIRE

    Tena Suck, Martha Lilia; Fabíán San Miguel,María Guadalupe; Molina Cárdenas,Hugo Roberto; Parraguirre Martínez,Sara

    2004-01-01

    La mortalidad por eclampsia varía entre el rango de 0 al 20% según las diferentes series a nivel mundial. La muerte de las pacientes con eclampsia puede presentarse como resultado de la asociación de factores clinicopatológicos y terapéuticos. Una frecuencia alta de muerte por eclampsia se atribuye a complicaciones cerebrales y sobre todo a la hemorragia cerebral, factores que se asocian a daño renal y hepático, así como a la coagulación intravascular diseminada, situación que se presenta en ...

  1. Insuficiencia renal aguda asociada a picadura de abeja africanizada

    Directory of Open Access Journals (Sweden)

    Verny Huertas-Franco

    2008-03-01

    Full Text Available Se presenta el caso de un adulto mayor diabético tipo 2, que sufrió un ataque masivo de abejas africanizadas, y llegó a la sala de emergencias tres horas después del inicio del ataque. El paciente presentó insuficiencia renal aguda por combinación de factores, y se recuperó con tratamiento de diálisis temprana. Se discuten los problemas que refieren estos pacientes, y cuál sería el manejo ideal de tales casos.

  2. Preeclampsia-Eclampsia Adverse Outcomes Reduction: The Preeclampsia-Eclampsia Checklist

    Directory of Open Access Journals (Sweden)

    Oroma B. Nwanodi

    2016-05-01

    Full Text Available Globally, preeclampsia-eclampsia (PE-E is a major cause of puerperal intensive care unit admission, accounting for up to 10% of maternal deaths. PE-E primary prevention is possible. Antepartum low-dose aspirin prophylaxis, costing USD $10–24 can cut the incidence of PE-E in half. Antepartum low molecular weight heparin combined with low-dose aspirin prophylaxis can cut the incidence of early onset PE-E and fetuses that are small for their gestational age in half. Despite predictive antepartum models for PE-E prophylaxis, said prophylaxis is not routinely provided. Therefore, magnesium sulfate secondary prevention of eclampsia remains the globally recommended intervention. Implementation of a PE-E checklist is a continuous quality improvement (CQI tool facilitating appropriate antepartum PE-E prophylaxis and maternal care from the first trimester through the postpartum fourth trimester inter-partum interval. A novel clinical PE-E checklist and implementation strategy are presented below. CQI PE-E checklist implementation and appropriate PE-E prophylaxis provides clinicians and healthcare systems an opportunity to achieve Millennium Development Goals 4 and 5, reducing child mortality and improving maternal health. While CQI checklist implementation may be a tedious ongoing process requiring healthcare team resiliency, improved healthcare outcomes are well worth the effort.

  3. Fracturas costales múltiples asociadas a tos

    Directory of Open Access Journals (Sweden)

    Martín Bosio

    2008-10-01

    Full Text Available La tos es un frecuente motivo de consulta en la práctica ambulatoria. Aunque generalmente es autolimitada, cuando es crónica e intensa puede ser causa de complicaciones como síncope, neumotórax o más raramente fracturas costales. Presentamos un paciente con fracturas costales múltiples inducidas por la tos. El diagnóstico fue confirmado por un centellograma solicitado luego de la sospecha clínica debida a la intensidad y persistencia del dolor y a pesar de no mostrar alteraciones en las radiografías convencionales. Un centellograma de control a los 5 meses mostró desaparición de los focos hipercaptantes. Las fracturas costales múltiples son una complicación infrecuente de la tos que debería considerarse cuando el dolor torácico es intenso y persistente aun con radiografía de tórax o parrilla costal normal.Multiple rib fractures associated with cough

  4. Psicosis asociada a megacisterna magna Psychosis associated to megacisterna magna

    Directory of Open Access Journals (Sweden)

    M. Langarica

    2005-04-01

    Full Text Available La megacisterna magna es una malformación de las estructuras de la línea media cerebral, que existe a lo largo de un continuo con la hipoplasia cerebelar (variante de Dandy-Walker y la agenesia cerebelar (síndrome de Dandy-Walker. Actualmente los trastornos psicóticos, y la esquizofrenia en particular, son conceptualizados como trastornos del neurodesarrollo. Presentamos el caso de un paciente con un trastorno psicótico, de tipo delirante, y una megacisterna magna. Se trata del primer caso documentado donde coexiste esta asociación, y se sugiere que tanto el trastorno psicótico como la megacisterna magna pueden ser expresión de la misma anomalía del neurodesarrollo.Megacisterna magna is a developmental malformation of the middle-line brain structures, which exists along a continuum with cerebellum hypoplasia (Dandy-Walker variant and cerebellum agenesia (Dandy-Walker syndrome. Psychotic disorders, and particularly schizophrenia, are now conceptualised as disorders of neurodevelopment. We report on a patient who presented a psychotic disorder (delusional type, and mega cisterna magna. This is the first report of such an association, and it is suggested that both the psychotic disorder and the mega cisterna magna may be the expression of a single underlying neurodevelopment abnormality.

  5. Neumonía intersticial linfoidea asociada a inmunodeficiencia común variable Interstitial lymphoid pneumonia associated with common variable immunodeficiency

    Directory of Open Access Journals (Sweden)

    Gonzalo Peralta

    2011-10-01

    Full Text Available La neumonía intersticial linfoidea (NIL es una rara entidad, descripta como hiperplasia no neoplásica del tejido linfoide pulmonar y clasificada dentro de las enfermedades intersticiales idiopáticas. Se la ha descripto asociada a infección por HIV, fenómenos autoinmunes, hipergamaglobulinemia policlonal o menos frecuentemente a hipogammaglobulinemia. Presentamos una paciente de 66 años de edad con diabetes mellitus, síndrome de Sjögren e hipertensión arterial, derivada a nuestro centro por tos seca y disnea clase funcional II-III. En el examen físico presentaba rales tipo “velcro” bibasales y esplenomegalia. Los estudios de laboratorio evidenciaron plaquetopenia (50 000/mm³ e hipogammaglobulinemia; la tomografía axial computarizada (TAC de tórax mostró compromiso intersticial bibasal, con nódulos peribroncovasculares menores a un centímetro. Se realizó una videotoracoscopia con biopsia pulmonar, la anatomía patológica mostró hallazgos compatibles con neumonía intersticial linfoidea. Se inició tratamiento con metilprednisona 40 mg/día vía oral e infusión endovenosa de gammaglobulina 500 mg/kg, mensual, evolucionando con mejoría clínico-radiológica. Por persistencia de plaquetopenia, asociada a hiperesplenismo, se realizó esplenectomía con buena respuesta. En la anatomía patológica no se observo clonalidad linfoide.The interstitial lymphoid pneumonia (LIP is an uncommon disorder, described as non-neoplastic lung lymphoid tissue hyperplasia and classified as an interstitial lung disease. It has been described in association with HIV infection, autoimmune disorders, policlonal hypergammaglobulinemia and less frequently, with hypogammaglobulinemia. We report the case of a 66 year old female patient with a history of diabetes, Sjögren syndrome and hypertension. She was referred to our hospital due to a dry cough and dyspnea (FC II-III. The physical examination showed bilateral dry crackles and splenomegaly

  6. Aortic dissection accompanied by preeclampsia in a postpartum young woman

    Science.gov (United States)

    Park, Jin-Wan; Kim, Su-Mi; Yu, Gyu-Bong

    2016-01-01

    Aortic dissection is very rare in obstetrics, but it is a fatal disease. A 37-weeks primigravida woman with dyspnea and pitting edema presented to our emergency room. The patient was diagnosed with preeclampsia and underwent an emergency cesarean section under spinal anesthesia. The patient complained of severe dyspnea after the cesarean section, and the chest computed tomography scan was done. With the finding of aortic dissection, cardiopulmonary arrest occurred 5 hours after the cesarean section, and the patient died without reaction to cardio-pulmonary resuscitation. If a patient with preeclampsia complains of severe dyspnea or chest pain, aortic dissection needs to be suspected and a diagnosis should not be delayed. PMID:27668205

  7. ALTERATIONS OF SERUM URIC ACID CONCETRATIONS IN PREECLAMPSIA

    Directory of Open Access Journals (Sweden)

    T.Sharmila Krishna

    2015-05-01

    Full Text Available Hypertensive disorders during pregnancy increase maternal and fetal risk. Preeclampsia is characterised by hypertension and proteinuria. Increased uric acid is a key clinical feature of preeclampsia; higher levels correlate with significant maternal and fetal morbid ity and mortality. The present study was undertaken to estimate serum uric acid , the end product of purine cata bolism, in clinically diagnose d preeclamptic women (n=30 and the values were compared with that of normotensive pregnant women (n=30 ,aged 18-30yrs. All of them were in their third trimester and primigravida. Serum uric acid le vels were measured by spec trophotometry. We observed that serum uric acid levels were increased significantly when compared with that of normotensive pregnant women (p value < 0.000.

  8. Cabestrillo subtrigonal con aponeurosis abdominal en el tratamiento de incontinencia urinaria de esfuerzo compleja

    OpenAIRE

    Eduardo Alonso Serrano-Brambila; Efraín Maldonado-Alcaraz; Xavier Abraham Espinoza-Guerrero; Jorge Moreno-Palacios; Guillermo Antonio Ixquiac-Pineda; Edgar Cárdenas-Rodríguez

    2009-01-01

    Objetivo: Describir la técnica de cabestrillo subtrigonal con fascia abdominal y demostrar su utilidad en la resolución de la incontinencia urinaria de esfuerzo compleja. Material y métodos: Estudio de cohorte longitudinal y observacional en mujeres adultas que acudieron al Servicio de Urodinamia, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, para tratamiento de incontinencia urinaria de esfuerzo recidivante o con factores de riesgo para recidiva, asociada o no a incontinencia...

  9. Reconstrucción de antebrazo con colgajo DIEP: caso clínico

    OpenAIRE

    2015-01-01

    Las heridas complejas del antebrazo con fracturas asociadas y pérdida circunferencial de piel, suponen un doble reto reconstructivo. Mostramos el tratamiento de una paciente con lesiones combinadas en el miembro superior tras atrapamiento por rodillos fríos industriales mediante el uso de un colgajo libre de perforante del eje epigástrico inferior profundo (DIEP), tras tratamiento de la fractura articular de la extremidad distal de radio guiado por artroscopia. Conseguimos la estabilización d...

  10. Acción de las olas sobre comunidades epibentónicas asociadas a raíces de Rhizophora mangle (Linnaeus

    Directory of Open Access Journals (Sweden)

    García R. Camilo B.

    2007-12-01

    Full Text Available Se sugiere un nuevo método de censo para comunidades bentónicas sésiles que tiene en cuenta la epibiosis y la complejidad comunitaria. La distribución entre sitios y vertical de especies es examinada en sitios con alto y bajo oleaje. Se examina como el oleaje determina mecanismos como el reclutamiento y algunas interacciones bióticas. Se relacionan estos mecanismos con la distribución vertical de las especies en las porciones de la raíz de mangle que están en el intermareal y en el submareal. Se propone un esquema idealizado de distribución vertical de especies para sitios con alto y bajo oleaje. La dinámica a pequeña escala fue examinada en huecos naturales de la biota sésil en las raíces de manglar. La recolonización de los huecos fue examinada y se relacionó con la teoría. La supervivencia de adultos, reclutas, organismos solitarios y coloniales fue examinada experimentalmente. Con la información experimental de la recolonización de los huecos y la supervivencia se examinaron las propiedades comunitarias de las comunidades naturales asociadas
    con raíces de Rhizophora mangle. Se relacionaron las propiedades comunitarias con la hipótesis del distur-bio
    intermedio. Se examinó experimentalmente la sucesión haciendo énfasis en el reemplazo direccional de especies. Se presentan las características de las comunidades en sitios con alto y bajo oleaje.

  11. Preeclampsia or initial diagnosis of chronic renal disease during pregnancy.

    Science.gov (United States)

    Iavazzo, C; Kalmantis, K; Bozemberg, T; Ntziora, F; Ioakeimidis, A; Paschalinopoulos, D

    2008-01-01

    An unusual case of early nephrotic syndrome without hypertension which slightly resolved after delivery is documented. Renal biopsy was performed postpartum and the diagnosis was focal and segmental glomerulosclerosis with moderate chronic renal changes. It is questioned whether the case was due to preeclampsia or was the initial diagnosis of chronic renal disease which was made during pregnancy. The role of renal biopsy in such cases is briefly discussed (Tab. 2, Ref. 15). Full Text (Free, PDF) www.bmj.sk.

  12. Clinical Practice Guidelines for Pre-eclampsia and Eclampsia Treatment.

    Directory of Open Access Journals (Sweden)

    Frank Carlos Alvarez Li

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Pre-eclampsia and Eclampsia Treatment. This disease is part of a group of conditions known as hypertensive disease in pregnancy that have in common the existence of high blood pressure. This document includes a review and update of the main clinical aspects, concepts, classification and treatment stressing the use of drugs that cause hypotension and magnesium sulphate. It includes assessment guidelines focused on the most important aspects to be accomplished.

  13. The relationship between maternal blood group and preeclampsia

    Directory of Open Access Journals (Sweden)

    Manjunatha S.

    2015-12-01

    Conclusions: The present study indicates that AB blood group have the highest risk of developing preeclampsia. AB blood group is associated with an increased risk of thrombotic events this may be the cause of increased incidence of PIH in this group. Thus attention should be given to the AB blood group pregnant women in order to prevent the PIH. [Int J Reprod Contracept Obstet Gynecol 2015; 4(6.000: 1749-1752

  14. Preeclampsia in pregnancy and later use of antihypertensive drugs

    OpenAIRE

    Engeland, Anders; Bjørge, Tone; Klungsøyr, Kari; Skjaerven, Rolv; Skurtveit, Svetlana; Furu, Kari

    2015-01-01

    We explored the association between preeclampsia and later use of antihypertensive drugs in a population-based study with data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. The study cohort consisted of 980,000 women having 2.1 million pregnancies during 1967–2012. Hazard ratios (HRs) with 95 % confidence intervals (95 % CI) were estimated in multivariate time-dependent Cox proportional hazards regression models. Overall, the HR of later use of antihyperte...

  15. Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond.

    Science.gov (United States)

    Xia, Yang; Kellems, Rodney E

    2013-06-21

    Hypertensive disorders are life-threatening diseases with high morbidity and mortality, affecting billions of individuals worldwide. A multitude of underlying conditions may contribute to hypertension, thus the need for a plethora of treatment options to identify the approach that best meets the needs of individual patients. A growing body of evidence indicates that (1) autoantibodies that bind to and activate the major angiotensin II type I (AT₁) receptor exist in the circulation of patients with hypertensive disorders, (2) these autoantibodies contribute to disease pathophysiology, (3) antibody titers correlate to the severity of the disease, and (4) efforts to block or remove these pathogenic autoantibodies have therapeutic potential. These autoantibodies, termed AT₁ agonistic autoantibodies have been extensively characterized in preeclampsia, a life-threatening hypertensive condition of pregnancy. As reviewed here, these autoantibodies cause symptoms of preeclampsia when injected into pregnant mice. Somewhat surprisingly, these auto antibodies also appear in 3 animal models of preeclampsia. However, the occurrence of AT₁ agonistic autoantibodies is not restricted to pregnancy. These autoantibodies are prevalent among kidney transplant recipients who develop severe transplant rejection and malignant hypertension during the first week after transplantation. AT₁ agonistic autoantibodies are also highly abundant among a group of patients with essential hypertension that are refractory to standard therapy. More recently these autoantibodies have been seen in patients with the autoimmune disease, systemic sclerosis. These 3 examples extend the clinical impact of AT₁ agonistic autoantibodies beyond pregnancy. Research reviewed here raises the intriguing possibility that preeclampsia and other hypertensive conditions are autoimmune diseases characterized by the presence of pathogenic autoantibodies that activate the major angiotensin receptor, AT₁. These

  16. Pregnancy Hypertenssion and Preeclampsia in Enviromental Expossure to Carbon Monoxide

    OpenAIRE

    2008-01-01

    Introduction: In this study relationship between carbon monoxide (CO) with pregnancy induced hypertension and preeclampsia in mothers in various levels of CO pollution was evaluated. Methods: The study was carried out in three teaching hospitals and 4500 pregnant women living area divided in one low-level CO polluted and as the second level, three moderate to high polluted areas (central, south and west). The subjects, residence places were within 5 kilometers of the air pollution monitoring ...

  17. Maternal-fetal interactions, predictive markers for preeclampsia, and programming.

    Science.gov (United States)

    Huppertz, Berthold

    2015-04-01

    During pregnancy close interactions between the maternal system and the fetal system via the placenta exist that result in a powerful crosstalk between both individuals. Looking for predictive biomarkers in maternal blood is extremely difficult because of this crosstalk as such markers may be derived from only maternal sources, only placental sources or both. In particular, the concentrations of markers derived from both sources may vary because of the huge variety of reasons and sources. During the last decade this has misled a number of scientists and clinicians who tried to decipher the sources of markers and the impact of the placenta and/or the maternal vascular system. A few examples for predictive biomarkers are presented, the placenta-specific marker placental protein 13 (PP13) and the angiogenic marker PlGF being released from both mother and placenta. Finally, a further reason why biomarkers may not be successful in predicting all cases of preeclampsia is that different causative routes lead to the development of preeclampsia. The differences in the development of preeclampsia not only explain why markers may or may not have a predictive value, but also why some mothers and/or children may display long-term effects later in life.

  18. Progression of pre-eclampsia to eclampsia under spinal anaesthesia

    Directory of Open Access Journals (Sweden)

    Longinus N Ebirim

    2012-01-01

    Full Text Available Eclampsia remains a problem in the developing countries despite improvements in antenatal care and emergency obstetric facilities. It is an important cause of maternal morbidity and mortality in Nigeria. A 26-year-old primipara, residing in an urban city in Nigeria with antenatal care facilities, booked for antenatal care at 36 weeks of gestation and was then diagnosed with severe pre-eclampsia. She initially refused therapy and was later booked for an emergency cesarean section. She had eclamptic fits during cesarean section under spinal anesthesia, and the seizure was aborted with intravenous diazepam. The postoperative period was uneventful. Progression of pre-eclampsia to eclampsia during cesarean section under spinal anesthesia is rare, but it can occur. Early booking for antenatal care to enable an early diagnosis and treatment are necessary to prevent the progression of pre-eclampsia to eclampsia. There is need to educate the populace on the importance of ante natal care so as to improve its utilization.

  19. A case of severe preeclampsia presenting as acute pulmonary oedema

    Directory of Open Access Journals (Sweden)

    D. Sumangala Devi

    2016-03-01

    Full Text Available Pulmonary edema refers to an excessive accumulation of fluid in the pulmonary interstitial and alveolar spaces. It may occur in low risk pregnancies but one very important predisposing factor is association with preeclampsia. We are reporting a case of severe preeclampsia presenting as acute pulmonary oedema. 21 year old primi, a known case of gestational hypertension on drugs had pedal edema which was progressively increasing. She was admitted at 29w5d as her BP was still high. Since her preeclampsia profile was normal and her BP was controlled she was continued on conservative management. After 2 days she developed cough, tachypnoea and tachycardia with clinical findings suggestive of A/c pulmonary oedema. Shifted to HDU and started on diuretics and other symptomatic management. After 1 hour as patient's condition was worsening with O2 saturation fall, decided for LSCS + elective post operative ventilatory support. LSCS done showed evidence of Grade 3 abruption with couvelaire changes on uterus. Baby weighed 1.24 kg, severely asphyxiated, died after 3 days. Patient was put on ventillatory support and she improved postoperatively. Acute pulmonary oedema in pregnant women is a life-threatening event. Prompt diagnosis and management is very important for the survival of the patient. [Int J Reprod Contracept Obstet Gynecol 2016; 5(3.000: 899-902

  20. Haptoglobin phenotype, preeclampsia risk and the efficacy of vitamin C and E supplementation to prevent preeclampsia in a racially diverse population.

    Directory of Open Access Journals (Sweden)

    Tracey L Weissgerber

    Full Text Available Haptoglobin's (Hp antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular disease risk and treatment response to antioxidant vitamins in some non-pregnant populations. We previously demonstrated that preeclampsia risk was doubled in white Hp 2-1 women, compared to Hp 1-1 women. Our objectives were to determine whether we could reproduce this finding in a larger cohort, and to determine whether Hp phenotype influences lack of efficacy of antioxidant vitamins in preventing preeclampsia and serious complications of pregnancy-associated hypertension (PAH. This is a secondary analysis of a randomized controlled trial in which 10,154 low-risk women received daily vitamin C and E, or placebo, from 9-16 weeks gestation until delivery. Hp phenotype was determined in the study prediction cohort (n = 2,393 and a case-control cohort (703 cases, 1,406 controls. The primary outcome was severe PAH, or mild or severe PAH with elevated liver enzymes, elevated serum creatinine, thrombocytopenia, eclampsia, fetal growth restriction, medically indicated preterm birth or perinatal death. Preeclampsia was a secondary outcome. Odds ratios were estimated by logistic regression. Sampling weights were used to reduce bias from an overrepresentation of women with preeclampsia or the primary outcome. There was no relationship between Hp phenotype and the primary outcome or preeclampsia in Hispanic, white/other or black women. Vitamin supplementation did not reduce the risk of the primary outcome or preeclampsia in women of any phenotype. Supplementation increased preeclampsia risk (odds ratio 3.30; 95% confidence interval 1.61-6.82, p<0.01 in Hispanic Hp 2-2 women. Hp phenotype does not influence preeclampsia risk, or identify a subset of women who may benefit from vitamin C and E supplementation to prevent preeclampsia.

  1. Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

    DEFF Research Database (Denmark)

    Nielsen, Lene Ringholm; Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger

    2011-01-01

    The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting that preecla......The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting...

  2. Serum TFAR19 Activity in Preeclampsia Patients%子痫前期患者血清中 TFAR19活性研究

    Institute of Scientific and Technical Information of China (English)

    仇秋明; 赵英伦

    2015-01-01

    preeclampsia patients,mild preeclampsia patients,and healthy con-trols were 43.56±2.93,33.38±2.32 and 23.63±2.94,respectively.The TFAR19 activity in each group was statistically significant difference (F = 10.65,P <0.01).Compared with healthy controls,the TFAR19 activity in severe preeclampsia group (q=6.384,P <0.001),mild preeclampsia group (q = 3.478,P =0.016)was statistically significant difference.The TFAR19 activity in preeclampsia patients subgroups (severe preeclampsia group,mild preeclampsia group)was statistically significant difference (q = 2.993,P = 0.037).Age between each groups was no-statistically significant difference (F =0.091,P =0.913).Gestation age and neonatal weight betweeneach groups was statistically significant difference (F=4.37, P =0.016;F=35.06,P <0.001).Conclusion The increase of TFAR19 could promote apoptosis,participating the occur-rence of preeclampsia.The content of TFAR19 could be increased with the severity of the preeclampsia.

  3. Lesiones oculares y perioculares asociadas a los traumatismos de órbita Ocular and periocular injuries associated to orbital trauma

    Directory of Open Access Journals (Sweden)

    J. C. Zambrano

    2007-12-01

    Full Text Available Los traumatismos faciales, en especial cuando se producen fracturas que comprometen la órbita, se relaciona en gran medida con daños de las estructuras blandas oculares y perioculares que pueden ser irreversibles. Por lo tanto, es imperativo sospechar y diagnosticar tempranamente las condiciones que ponen en riesgo el globo ocular y sus estructuras anexas y adyacentes para poder realizar un tratamiento temprano y efectivo y prevenir daños mayores. Presentamos una revisión del tema y el algoritmo de tratamiento utilizado en el Servicio de Cirugía Plástica del Hospital Universitario San Ignacio de Bogotá, Colombia, para detectar y tratar tempranamente lesiones oculares asociadas a los traumatismos faciales, potencialmente catastróficas para la función del ojo.Facial trauma, specially associated to fractures of the orbit, is related to a great extent of damages that can be irreversible to the ocular soft structures. Therefore it is imperative to suspect and to diagnose theese conditions that put in risk the ocular globe and its adjacent structures at an early stage, in order to be able to perform rapid and effective treatment to prevent greater damage. We present a review on the subject and the algorithm of treating used at the Service of Plastic Surgery of the Hospital San Ignacio, Bogotá, Colombia, for early detection and treatment of potentially catastrophic injuries to the eye, associated to the facial trauma.

  4. Ataque de viento externo con manifestaciones de parálisis facial periférica tratado con acupuntura

    OpenAIRE

    Pinzón Ramírez, Betty Alejandra

    2012-01-01

    El ataque de viento externo es considerado desde la medicina china como un síndrome patológico que puede cursar con manifestaciones de parálisis facial semejante a la parálisis de Bell o parálisis facial idiopática de la medicina occidental, la cual también es efectivamente tratada con acupuntura; sin embargo en la actualidad no hay estudios al respecto en nuestra población. El objetivo es describir las características de población, presentación y evolución de la parálisis facial asociada ...

  5. Actividades asistidas con perros orientadas al bienestar emocional en niños con parálisis cerebral

    OpenAIRE

    Gómez González, María

    2013-01-01

    Este trabajo se basa en el planteamiento de la relación existente entre las Intervenciones Asistidas con Animales y el bienestar emocional, entendido como satisfacción, alegría, sentimiento de valía y ausencia de estrés en personas con parálisis cerebral. Las personas que presentan este tipo de discapacidad pueden tener asociadas otras características afectivas y de personalidad cuya mejora puede verse favorecida mediante el incremento de su bienestar emocional. El trabajo que prese...

  6. Infección urinaria en pacientes con cateterismo vesical con sistema de drenaje cerrado, utilizando un frasco colector recambiable.

    OpenAIRE

    Valdez, Rosario; Miyahira Arakaki, Juan

    2014-01-01

    Con el objetivo de determinar la incidencia de ITU asociado a cateterismo vesical con sistema de drenaje cerrado utilizando un frasco recambiable, fueron evaluados 20 pacientes no críticos, cateterizados por 5 días. Se encontró una incidencia de bacteriuria asociada a cateterismo vesical de 5%, mientras que la contaminación del frasco de drenaje se documento en el 10% de los pacientes. Tanto la bacteriuría, como la contaminación del frasco colector ocurrieron a las 96 horas de cateterismo ves...

  7. Morphological Characteristics of Placental Complex in Pregnant Women without Complications in Pregnancy and in the Presence of Severe Preeclampsia

    Science.gov (United States)

    Umbetov, Turakbai Zh.; Berdalinova, Akzhenis K.; Tusupkalieyv, Akylbek B.; Koishybayev, Arip K.; Zharilkasynov, Karaman Ye.

    2016-01-01

    According to the WHO data, preeclampsia develops during late pregnancy in 2-8% of women. Preeclampsia is a major cause of maternal and perinatal morbidity and mortality, therefore, the study of the morphological features of placental complex, taking into account gestational complications in postpartum women with severe preeclampsia is an important…

  8. The increased maternal serum levels of IL-6 are associated with the severity and onset of preeclampsia.

    Science.gov (United States)

    Xiao, J P; Yin, Y X; Gao, Y F; Lau, S; Shen, F; Zhao, M; Chen, Q

    2012-12-01

    Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflammatory cytokine IL-6 has been postulated to be involved in some ways in the pathogenesis of preeclampsia. However studies investigating whether levels of IL-6 in the maternal circulation differ between the disease severities or between times of onset of preeclampsia, or between preeclamptic pregnancies that are or are not complicated by fetal growth restriction (FGR) are limited. 104 women with preeclampsia and 75 health pregnant women were included into this study. The levels of IL-6 in maternal circulation were measured by enzyme-linked immunosorbent assay (ELISA). The levels of IL-6 in serum were significantly increased in women with preeclampsia in early onset and late onset preeclampsia compared to gestation matched health pregnant women. In addition, the levels of IL-6 were significantly increased in women with severe preeclampsia, but not with mild preeclampsia compared to gestation matched health pregnant women. Furthermore there was no correlation in IL-6 levels between preeclamptic with or without FGR. Our data shows increased level of circulating IL-6 levels in both women with early onset or late onset preeclampsia and in women with severe preeclampsia. These results suggest the excessive maternal inflammatory response in preeclampsia.

  9. Atrial Natriuretic Peptide (ANP) in early pregnancy is associated with development of preeclampsia in type 1 diabetes

    DEFF Research Database (Denmark)

    Nielsen, Lene Ringholm; Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger;

    2011-01-01

    The vasoactive markers of cardiac overload Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) are elevated in preeclampsia. This study documents higher ANP concentrations as early as at 9 weeks in type 1 diabetic women subsequently developing preeclampsia suggesting...... that preeclampsia is associated with cardiovascular changes in early pregnancy....

  10. Paquimeningitis hipertrófica, glomerulonefritis y vasculitis de pequeños vasos asociada a ANCA Hypertrophic pachymeningitis, glomerulonephritis and P-ANCA associated small vessel vasculitis

    Directory of Open Access Journals (Sweden)

    Octavio Mazzocchi

    2007-04-01

    Full Text Available La paquimeningitis hipertrófica es una enfermedad poco frecuente caracterizada por engrosamiento de la duramadre. Presentamos una paciente con esta enfermedad que se manifestó con cefalea crónica y en la que concomitantemente se evidenció una glomerulonefritis necrotizante extracapilar pauciinmune asociada a anticuerpos anticitoplasma de neutrófilos de patrón perinuclear (ANCA-P. El diagnóstico se estableció por resonancia nuclear magnética. Recibió tratamiento inmunosupresor con prednisona y ciclofosfamida con evolución favorable.Hypertrophic pachymeningitis is a very unusual disease, the main characteristic of which is thickening of the dura mater. We describe a patient who started this illness showing chronic headache and pauci-immune necrotizing extracapillary perinuclear antineutrophil cytoplasmic antibody (P-ANCA associated glomerulonephritis. The diagnosis was made by brain magnetic resonance image. She received immunosuppressant therapy with prednisonel and cyclophosphamide with clinical improvement.

  11. Sellado de aneurisma coronario con stent cubierto de PTFE (stent graft)

    OpenAIRE

    Portero Pérez,Ma Pilar; Ortas Nadal,Ma Rosario; Ruiz Arroyo,José Ramón; Escota Villanueva,Javier; Peleato Peleato,Antonio

    2008-01-01

    Los aneurismas coronarios son muy raros, su frecuencia oscila entre el 1 y el 2%, siendo la aterosclerosis la enfermedad más asociada, aunque se han descrito los de origen congénito, los asociados a la enfermedad de Kawasaki, a enfermedades del tejido conectivo, a enfermedades infecciosas y a traumatismos torácicos. También se observan los relacionados con la implantación del stent, con la braquiterapia intracoronaria y con los "stents" recubiertos de fármacos. Su evolución no es muy bien con...

  12. Reducción de la mortalidad materna por preeclampsia mediante la aplicación de un modelo biopsicosocial en Colombia

    OpenAIRE

    Herrera Murgueitio, Julián Alberto

    2013-01-01

    La pre-eclampsia es la causa más importante de mortalidad materna en los países en vías de desarrollo. Un programa integral de atención prenatal incluyendo componentes biopsicosociales fue desarrollado e introducido a nivel nacional en Colombia. Se describen las tendencias de las razones de mortalidad materna y sus causas relacionadas con el antes y después de la introducción de este programa. Métodos: Las razones de mortalidad materna general y específica fueron monitoreados durante trece añ...

  13. History of preeclampsia is not associated with an increased risk of thyroid dysfunction

    NARCIS (Netherlands)

    Dekker, Ruth R.; Jochemsen, B.M.; van Pampus, M.G.; Santema, J.G.; Roozendaal, C.; Groen, H.; Links, T.P.; van Doormaal, J.J.

    2010-01-01

    Objective. We evaluated the thyroid function in women with a history of preeclampsia and/or HELLP syndrome at least 2 years after delivery. Design. Observational retrospective study. Setting. University Medical Center Groningen, The Netherlands. Population. Women with a history of preeclampsia and/o

  14. Changes in homocysteine levels during normal pregnancy and preeclampsia and its relation with oxidative stress

    Directory of Open Access Journals (Sweden)

    Shilpa A. V.

    2016-12-01

    Conclusions: The increased homocysteine levels in preeclampsia results in endothelial dysfunction and vasospasm. Also oxidative stress plays an important role in the pathogenesis of preeclampsia. Thus identifying the risk factors and aggressive management may prove to be beneficial in these women.

  15. Endothelial Nitric Oxide Synthase Haplotypes Are Associated with Preeclampsia in Maya Mestizo Women

    Directory of Open Access Journals (Sweden)

    Lizbeth Díaz-Olguín

    2011-01-01

    Full Text Available Preeclampsia is a specific disease of pregnancy and believed to have a genetic component. The aim of this study was to investigate if three polymorphisms in eNOS or their haplotypes are associated with preeclampsia in Maya mestizo women.

  16. Clinical risk factors for gestational hypertensive disorders in pregnant women at high risk for developing preeclampsia

    NARCIS (Netherlands)

    Wong, Tsz Y.; Groen, Henk; Faas, Marijke M.; van Pampus, Maria G.

    2013-01-01

    Objectives: To evaluate clinical risk factors for the development of gestational hypertensive disorders in a group of pregnant women at high risk for developing preeclampsia. Secondly we evaluated the incidence and recurrence rate of preeclampsia and pregnancy-induced hypertension. Study design: A p

  17. Decreased ovarian reserve relates to pre-eclampsia in IVF/ICSI pregnancies.

    NARCIS (Netherlands)

    Woldringh, G.H.; Frunt, M.H.A.; Kremer, J.A.M.; Spaanderman, M.E.A.

    2006-01-01

    BACKGROUND: Pre-eclampsia affects 2-10% of all pregnancies and is a major cause of maternal and fetal morbidity and mortality. As compared with the general population, IVF pregnancies are associated with a 2.7-fold risk of pre-eclampsia. An advanced age and associated subfertility in the IVF group r

  18. Risk Factors of Superimposed Preeclampsia in Women with Essential Chronic Hypertension Treated before Pregnancy

    OpenAIRE

    2013-01-01

    OBJECTIVE: To determine risk factors of superimposed preeclampsia in women with essential chronic hypertension receiving antihypertensive therapy prior to conception. METHODS: A retrospective study of 211 patients that analyzed risk factors of superimposed preeclampsia at first prenatal visit. Variables with a p

  19. Follow up of intima-media thickness after severe early-onset preeclampsia

    NARCIS (Netherlands)

    Blaauw, Judith; Souwer, Esteban T D; Coffeng, Sophie M; Smit, Andries J; van Doormaal, Jasper J; Faas, Marijke M; van Pampus, Maria G

    2014-01-01

    OBJECTIVE: Early-onset preeclampsia is associated with premature cardiovascular disease. We previously demonstrated that femoral intima-media thickness (IMT) and markers of cardiovascular disease were increased in women 1 year after early-onset preeclampsia. The current study measured (progression o

  20. Severe preeclampsia cured by heparin in a patient with twin-twin transfusion syndrome

    Institute of Scientific and Technical Information of China (English)

    CHU Hong-nü; ZHOU Cai-yun

    2007-01-01

    @@ Heparin therapy for preeclampsia has been reported frequently.1-3 Most of the authors used heparin to prevent thrombosis and achieved good results. But its mechanism is not clear.4 Here we describe a case of severe early-onset preeclampsia complicated with hypercoagulable state, fetal growth restriction, and twin-twin transfusion syndrome, that responded well to heparin.

  1. Preeclampsia in autologous and oocyte donation pregnancy: is there a different pathophysiology?

    Science.gov (United States)

    Lashley, Lisa E E L O; Buurma, Aletta; Swings, Godelieve M J S; Eikmans, Michael; Anholts, Jacqueline D H; Bakker, Jaap A; Claas, Frans H J

    2015-06-01

    Oocyte donation (OD) is a specific method of artificial reproductive technology that is accompanied by a higher risk of preeclampsia during pregnancy. The pathophysiological mechanism underlying preeclampsia in OD pregnancies is thought to differ from preeclampsia in autologous pregnancies. As preeclampsia in autologous pregnancies is suggested to be associated with complement activation, we studied C4d deposition, circulating complement components and placental complement regulatory proteins in preeclamptic OD pregnancies. Women with uncomplicated and preeclamptic pregnancies after OD or spontaneous conception were selected. We stained the placentas for C4d, marker for complement activation, measured complement factors C1q, C3 and C4 in maternal sera and quantified the placental mRNA expression of complement regulatory proteins CD46, CD55 and CD59. A significantly (p preeclampsia compared with uncomplicated pregnancies, both OD and autologous. The level of complement factors in serum did not differ between the groups. Children born in the autologous preeclampsia group were significantly lower in birth weight (p preeclampsia pregnancies, there is excessive activation of complement in preeclamptic OD pregnancies. However, in contrast to autologous pregnancies this is not associated with counterbalancing upregulation of complement regulatory proteins. Furthermore, C4d deposition in OD pregnancies is not related to the severity of preeclampsia, suggesting another trigger or regulatory mechanism of placental C4d deposition in preeclamptic OD pregnancies.

  2. VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population.

    Science.gov (United States)

    Amosco, Melissa D; Villar, Van Anthony M; Naniong, Justin Michael A; David-Bustamante, Lara Marie G; Jose, Pedro A; Palmes-Saloma, Cynthia P

    The vascular endothelial growth factor (VEGF) family is important for establishing normal pregnancy, and related single nucleotide polymorphisms (SNPs) are implicated in abnormal placentation and preeclampsia. We evaluated the association between preeclampsia and several VEGF SNPs among Filipinos, an ethnically distinct group with high prevalence of preeclampsia. The genotypes and allelic variants were determined in a case-control study (191 controls and 165 preeclampsia patients) through SNP analysis of VEGF-A (rs2010963, rs3025039) and VEGF-C (rs7664413) and their corresponding receptors VEGFR1 (rs722503, rs12584067, rs7335588) and VEGFR3 (rs307826) from venous blood DNA. VEGF-A rs3025039 C allele has been shown to associate with preeclampsia (odds ratio of 1.648 (1.03-2.62)), while the T allele bestowed an additive effect for the maintenance of normal, uncomplicated pregnancy and against the development of preeclampsia (odds ratio of 0.62 (0.39-0.98)). VEGFR1 rs722503 is associated with preeclampsia occurring at or after the age of 40 years. The results showed that genetic variability of VEGF-A and VEGFR1 are important in the etiology of preeclampsia among Filipinos.

  3. [46-OR] : Early and late onset preeclampsia versus small for gestational age risks in subsequent pregnancies

    NARCIS (Netherlands)

    Bernardes, Thomas P; Mol, Ben W; Ravelli, Anita C; van den Berg, Paul P; Stolk, Ronald P; Groen, Henk

    2015-01-01

    OBJECTIVES: Current literature suggests that early and late onset preeclampsia should be treated as distinct entities and that early onset preeclampsia shares pathophysiology aspects with intrauterine growth restriction. Our objective was to investigate whether 5th percentile small for gestational a

  4. Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes

    DEFF Research Database (Denmark)

    2010-01-01

    We evaluated the urinary orosomucoid excretion (UOE) as a biomarker of preeclampsia and preterm delivery in pregnant women with type 1 diabetes.......We evaluated the urinary orosomucoid excretion (UOE) as a biomarker of preeclampsia and preterm delivery in pregnant women with type 1 diabetes....

  5. Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women

    Institute of Scientific and Technical Information of China (English)

    Luo Dong; Zhang Yanyan; Bai Yi; Liu Xijing; Gong Yunhui; Zhou Bin; Zhang Lin

    2014-01-01

    Background Preeclampsia,characterized by hypertension and proteinuria,is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling.Trophoblast and tumor cells have similar invasion mechanism.Prostasin is closely related to tumor development,invasion and metastasis and influences blood pressure through activating epithelial sodium channel.The effect of prostasin on the pathogenesis of preeclampsia remains unclear.This study investigated the association of prostasin gene at rs12597511 with severe preeclampsia.Methods A single nucleotide polymorphism,rs12597511,was tested with polymerase chain reaction and restrictionfragment length polymorphism analyses in 179 severe preeclampsia patients and 222 normal pregnant women.Results The frequencies of TC + CC genotypes were significantly higher in severe preeclampsia group compared with in control group (the adjusted odds ratio was 2.030,95% confidence interval 1.195-3.449,P=0.009).The C allele of rs12597511 was present significantly more often among women with severe preeclampsia (P=0.001).Genotyping analysis showed that the C allele of rs12597511 could confer a risk for severe preeclampsia.Conclusion The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.

  6. Determinants of future cardiovascular health in women with a history of preeclampsia

    NARCIS (Netherlands)

    Zoet, G.A.; Koster, M.P.; Velthuis, B.K.; Groot, C.J. de; Maas, A.H.E.M.; Fauser, B.C.; Franx, A.; Rijn, B.B. van

    2015-01-01

    Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in

  7. Oxidized low-density lipoprotein (Oxidized LDL) and the risk of preeclampsia.

    Science.gov (United States)

    Qiu, C; Phung, T T T; Vadachkoria, S; Muy-Rivera, M; Sanchez, S E; Williams, M A

    2006-01-01

    Oxidative stress plays an important role in the pathophysiology of preeclampsia. In a case-control study of 99 women with preeclampsia and 99 controls, we assessed maternal plasma oxidized low-density lipoprotein (oxidized LDL) in relation to preeclampsia risk. Logistic regression procedures were used to derive odds ratios (OR) and 95 % confidence intervals (CI). Plasma oxidized LDL was determined using enzyme immunoassay. Maternal plasma oxidized LDL was significantly positively correlated with lipids in both cases and controls. After adjusting for nulliparity, pre-pregnancy body mass index, physical inactivity, family history of chronic hypertension and plasma vitamin C concentrations, women who had elevated oxidized LDL concentrations ( > or = 50 U/l) experienced a 2.9-fold increased risk of preeclampsia when compared with women having lower oxidized LDL concentrations (95 % CI 1.4-5.9). The risk of preeclampsia was markedly increased in women who had both elevated oxidized LDL and elevated triglyceride concentrations (OR=8.9, 95 % CI 3.1-26.2). Women with both elevated oxidized LDL and low vitamin C concentrations experienced a 9.8-fold increased risk of preeclampsia (95 % CI 3.0-32.2). Our results confirm the role of oxidative stress in the pathogenesis of preeclampsia. Prospective studies are needed to determine if elevated oxidized LDL concentrations can predict the occurrence of preeclampsia.

  8. Biomarker identification and pathway analysis of preeclampsia based on serum metabolomics.

    Science.gov (United States)

    Chen, Tingting; He, Ping; Tan, Yong; Xu, Dongying

    2017-02-07

    Preeclampsia presents serious risk of both maternal and fetal morbidity and mortality. Biomarkers for the detection of preeclampsia are critical for risk assessment and targeted intervention. The goal of this study is to screen potential biomarkers for the diagnosis of preeclampsia and to illuminate the pathogenesis of preeclampsia development based on the differential expression network. Two groups of subjects, including healthy pregnant women, subjects with preeclampsia, were recruited for this study. The metabolic profiles of all of the subjects' serum were obtained by liquid chromatography quadruple time-of-flight mass spectrometry. Correlation between metabolites was analyzed by bioinformatics technique. Results showed that the PC(14:0/00), proline betaine and proline were potential sensitive and specific biomarkers for preeclampsia diagnosis and prognosis. Perturbation of corresponding biological pathways, such as iNOS signaling, nitric oxide signaling in the cardiovascular system, mitochondrial dysfunction were responsible for the pathogenesis of preeclampsia. This study indicated that the metabolic profiling had a good clinical significance in the diagnosis of preeclampsia as well as in the study of its pathogenesis.

  9. Relationship between renal histology and plasma antithrombin III activity in women with early onset preeclampsia.

    Science.gov (United States)

    Weiner, C P; Bonsib, S M

    1990-04-01

    Renal biopsy was performed in 12 women with the clinical diagnosis of severe, early-onset preeclampsia at the time of cesarean delivery for the express purpose of aiding future counseling on the risk of recurrence. The mean gestation at delivery was 30 +/- 3 weeks. The mean birthweight was 1090 +/- 505 gm. Four women (33%) were multiparous. Antithrombin III activity was determined immediately prior to delivery unrelated to clinical care and as part of other protocols. The biopsy was performed without difficulty in each, although the sample was inadequate in one patient. The clinical diagnosis of preeclampsia was confirmed in nine (82%). However, three of the nine had underlying renal disease, as did the two women without histologic evidence of preeclampsia (42% of the total). Correlations between laboratory parameters with the histopathologic diagnoses were sought. Neither uric acid, creatinine, blood urea nitrogen, platelet count, or 24-hour urinary protein measurements aided the differentiation of the various subgroups. Antithrombin III activity in women with biopsy-supported preeclampsia (77% +/- 12%) was significantly lower than that in women without histologic evidence of preeclampsia (116% +/- 8%). Antithrombin III activity correctly predicted biopsy findings in at least 9 of 11 (82%). These preliminary findings confirm the high frequency of underlying disease in women with early-onset preeclampsia. Although low antithrombin III activity does not differentiate between "pure" preeclampsia and superimposed disease, a normal antithrombin III activity is reassuring and more consistent with a nonpreeclamptic renal complication than with preeclampsia.

  10. Physical well-being in women with a history of severe preeclampsia.

    NARCIS (Netherlands)

    Roes, E.M.; Raijmakers, M.; Schoonenberg, M.P.G.; Wanner, N.; Peters, W.H.M.; Steegers, E.A.P.

    2005-01-01

    OBJECTIVE: To evaluate the physical and mental health of women with a history of severe preeclampsia. METHODS: In a historical cohort study 131 former patients with a history of severe preeclampsia and 127 control patients received questionnaires about experienced physical and mental complaints afte

  11. From Glomerular Endothelium to Podocyte Pathobiology in Preeclampsia : a Paradigm Shift

    NARCIS (Netherlands)

    Turner, Rosanne J.; Bloemenkamp, Kitty W M; Penning, Marlies E.; Bruijn, Jan Anthonie; Baelde, Hans J.

    2015-01-01

    Preeclampsia is a pregnancy-specific syndrome characterized by renal dysfunction and high blood pressure. When evaluated with light microscopy, the renal lesion of preeclampsia is marked by endothelial cell swelling and the appearance of bloodless glomeruli. However, regarding the pathobiology of re

  12. Patología oral asociada a la sequedad bucal

    Directory of Open Access Journals (Sweden)

    A. Blanco Carrión

    2014-06-01

    Full Text Available El síndrome de boca seca es un importante problema de salud ya que ocasiona intensas alteraciones funcionales y lesiones orales de carácter orgánico. Las alteraciones funcionales son las primeras en aparecer. Existe una dificultad en la masticación, deglución, fonación y alteración en la captación del gusto. Estos problemas pueden desencadenar cambios en la alimentación e incluso comprometer el estado nutricional. Las lesiones orales de carácter orgánico provocan una alteración de la mucosa oral, aparece brillante, seca, eritematosa, sensible, friable y, en ocasiones, dolorida, facilita la aparición de caries, de evolución rápida y de localización preferentemente cervical; enfermedad periodontal; malestar con el uso de prótesis; predisposición a las infecciones, sobre todo candidiasis; halitosis e incluso manifestaciones extraorales.

  13. Plasma concentration of atrial natriuretic peptide in normal pregnant women and in pregnant women with preeclampsia

    DEFF Research Database (Denmark)

    Mikkelsen, A L; Schütten, G; Asping, U;

    1991-01-01

    Plasma concentration of atrial natriuretic peptide (ANP) was determined in pregnant women with preeclampsia, in normal pregnant and in nonpregnant women by a specific radioimmunoassay. Results did not show important differences between nonpregnant controls and normal pregnant women, but a signifi......Plasma concentration of atrial natriuretic peptide (ANP) was determined in pregnant women with preeclampsia, in normal pregnant and in nonpregnant women by a specific radioimmunoassay. Results did not show important differences between nonpregnant controls and normal pregnant women......, but a significant rise was seen in women with preeclampsia compared to nonpregnant controls. Marked interindividual variation was found in all three groups. The mechanism of ANP release may differ between those women with normal pregnancy and those with preeclampsia. It is unclear whether the increased level of ANP...... in preeclampsia is an effect or a cause of the disease....

  14. Sex Ratio and Twinning in Women with Hyperemesis or Pre-eclampsia

    DEFF Research Database (Denmark)

    Basso, Olga; Olsen, Jørn

    2001-01-01

    We examined twinning and fetal gender in births of women with a hospital diagnosis of pre-eclampsia or hyperemesis. We also investigated sex ratio in infants whose mothers had had hyperemesis or pre-eclampsia in a different pregnancy. From all the hospitalized cases in Denmark between 1980 and 1996...... we extracted 6,227 births with hyperemesis and 24,764 with pre-eclampsia. Twins were more frequent in pregnancies with either condition. The male to female sex ratio was 1.04 (95%CI = 1.02-1.05) in the reference population, 0.87 (95% CI = 0.82-0.91) in births with hyperemesis, and 1.10 (95% CI = 1.......07-1.12) in births with pre-eclampsia. Women with pre-eclampsia had slightly more males also in non-affected pregnancies....

  15. Delta-aminolevulinate dehydratase activity and oxidative stress markers in preeclampsia.

    Science.gov (United States)

    de Lucca, Leidiane; Rodrigues, Fabiane; Jantsch, Letícia B; Kober, Helena; Neme, Walter S; Gallarreta, Francisco M P; Gonçalves, Thissiane L

    2016-12-01

    Preeclampsia is an important pregnancy-specific multisystem disorder characterized by the onset of hypertension and proteinuria. It is of unknown etiology and involves serious risks for the pregnant women and fetus. One of the main factors involved in the pathophysiology of preeclampsia is oxidative stress, where excess free radicals produce harmful effects, including damage to macromolecules such as lipids, proteins and DNA. In addition, the sulfhydryl delta-aminolevulinate dehydratase enzyme (δ-ALA-D) that is part of the heme biosynthetic pathway in pro-oxidant conditions can be inhibited, which may result in the accumulation of 5-aminolevulinic acid (ALA), associated with the overproduction of free radicals, suggesting it to be an indirect marker of oxidative stress. As hypertensive pregnancy complications are a major cause of morbidity and mortality maternal and fetal where oxidative stress appears to be an important factor involved in preeclampsia, the aim of this study was to evaluate the activity of δ-ALA-D and classic oxidative stress markers in the blood of pregnant women with mild and severe preeclampsia. The analysis and quantification of the following oxidative stress markers were performed: thiobarbituric acid-reactive species (TBARS); presence of protein and non-protein thiol group; quantification of vitamin C; Catalase and δ-ALA--D activities in samples of blood of pregnant women with mild preeclampsia (n=25), with severe preeclampsia (n=30) and in a control group of healthy pregnant women (n=30). TBARS was significantly higher in women with preeclampsia, while the presence of thiol groups, levels of vitamin C, catalase and δ-ALA-D activity were significantly lower in groups of pregnant women with preeclampsia compared with healthy women. In addition, the results showed no significant difference between groups of pregnant women with mild and severe preeclampsia. The data suggest a state of increased oxidative stress in pregnant women with

  16. Pre-eclampsia increases the risk of postpartum haemorrhage: a nationwide cohort study in the Netherlands.

    Directory of Open Access Journals (Sweden)

    Joost F von Schmidt auf Altenstadt

    Full Text Available BACKGROUND: Postpartum haemorrhage is a leading cause of maternal morbidity and mortality worldwide. Identifying risk indicators for postpartum haemorrhage is crucial to predict this life threatening condition. Another major contributor to maternal morbidity and mortality is pre-eclampsia. Previous studies show conflicting results in the association between pre-eclampsia and postpartum haemorrhage. The primary objective of this study was to investigate the association between pre-eclampsia and postpartum haemorrhage. Our secondary objective was to identify other risk indicators for postpartum haemorrhage in the Netherlands. METHODS: A nationwide cohort was used, containing prospectively collected data of women giving birth after 19 completed weeks of gestation from January 2000 until January 2008 (n =  1,457,576. Data were extracted from the Netherlands Perinatal Registry, covering 96% of all deliveries in the Netherlands. The main outcome measure, postpartum haemorrhage, was defined as blood loss of ≥1000 ml in the 24 hours following delivery. The association between pre-eclampsia and postpartum haemorrhage was investigated with uni- and multivariable logistic regression analyses. RESULTS: Overall prevalence of postpartum haemorrhage was 4.3% and of pre-eclampsia 2.2%. From the 31 560 women with pre-eclampsia 2 347 (7.4% developed postpartum haemorrhage, compared to 60 517 (4.2% from the 1 426 016 women without pre-eclampsia (odds ratio 1.81; 95% CI 1.74 to 1.89. Risk of postpartum haemorrhage in women with pre-eclampsia remained increased after adjusting for confounders (adjusted odds ratio 1.53; 95% CI 1.46 to 1.60. CONCLUSION: Women with pre-eclampsia have a 1.53 fold increased risk for postpartum haemorrhage. Clinicians should be aware of this and use this knowledge in the management of pre-eclampsia and the third stage of labour in order to reach the fifth Millenium Developmental Goal of reducing maternal mortality ratios with 75% by

  17. The role of genetics in pre-eclampsia and potential pharmacogenomic interventions

    Directory of Open Access Journals (Sweden)

    Williams PJ

    2012-01-01

    Full Text Available Paula Juliet Williams, Linda MorganHuman Genetics Research Group, University of Nottingham, Nottingham, UKAbstract: The pregnancy-specific condition pre-eclampsia not only affects the health of mother and baby during pregnancy but also has long-term consequences, increasing the chances of cardiovascular disease in later life. It is accepted that pre-eclampsia has a placental origin, but the pathogenic mechanisms leading to the systemic endothelial dysfunction characteristic of the disorder remain to be determined. In this review we discuss some key factors regarded as important in the development of pre-eclampsia, including immune maladaptation, inadequate placentation, oxidative stress, and thrombosis. Genetic factors influence all of these proposed pathophysiological mechanisms. The inherited nature of pre-eclampsia has been known for many years, and extensive genetic studies have been undertaken in this area. Genetic research offers an attractive strategy for studying the pathogenesis of pre-eclampsia as it avoids the ethical and practical difficulties of conducting basic science research during the preclinical phase of pre-eclampsia when the underlying pathological changes occur. Although pharmacogenomic studies have not yet been conducted in pre-eclampsia, a number of studies investigating treatment for essential hypertension are of relevance to therapies used in pre-eclampsia. The pharmacogenomics of antiplatelet agents, alpha and beta blockers, calcium channel blockers, and magnesium sulfate are discussed in relation to the treatment and prevention of pre-eclampsia. Pharmacogenomics offers the prospect of individualized patient treatment, ensuring swift introduction of optimal treatment whilst minimizing the use of inappropriate or ineffective drugs, thereby reducing the risk of harmful effects to both mother and baby.Keywords: pre-eclampsia, pharmacogenetics, placenta, trophoblast, genetics

  18. Perinatal Outcomes in Women with Preeclampsia: Experience of a Tertiary Referral Center

    Directory of Open Access Journals (Sweden)

    Semra Eroglu

    2015-11-01

    Full Text Available Aim: The purpose of this study was to investigate the association between maternal-fetal outcomes and the severity of preeclampsia. Material and Method: A total of 528 singleton pregnancies diagnosed with preeclampsia, severe preeclampsia or HELLP syndrome with pregnancies >24 weeks of gestation were retrospectively evaluated. For each patient, maternal age, gravidity, previous obstetric history, family history, gestational age at the time of hospitalization, systolic and diastolic blood pressures, presence of severe preeclampsia symptoms, laboratory values, dexamethasone use for the treatment of thrombocytopenia, route of delivery, maternal and perinatal outcomes were recorded. Results: Within the study period, the occurences of preeclampsia, HELLP syndrome and severe preeclampsia were 1.4%, 0.12% and 0.57%, respectively. In patients with HELLP syndrome, cesarean delivery rate, blood product transfusion, acute renal failure, liver function tests, D-dimer levels, neonatal respiratory distress syndrome (RDS, necrotizing enterocolitis (NEC, preterm retinopathy, pulmonary hemorrhage and sepsis occurrences, were significantly higher than in patients with mild and severe preeclampsia. On the contrary, platelet counts were significantly lower . In patients with mild preeclampsia, gestational age at the time of delivery, vaginal delivery rate, 1 and 5 minute APGAR score and newborn birthweight were significantly higher when compared to patients with severe preeclampsia or HELLP syndrome. In contrast, systolic and diastolic blood pressures, neonatal intensive care unit admission rate, hospital stay, protein levels in 24 hr urine, and maternal hemoglobin levels were significantly lower in this group. Discussion: In the present study, it was found that HELLP syndrome was more frequently associated with maternal complications and neonatal morbidities. For the prevention of morbidities due to these unpredictable syndromes with unclear etiologies

  19. Variables psicosociales asociadas al intento suicida, ideación suicida y suicidio en jóvenes

    Directory of Open Access Journals (Sweden)

    Mildred Alexandra Vianchá Pinzón

    2013-01-01

    Full Text Available El objetivo del presente artículo es reflexionar en torno a la relación entre ideación suicida, acto sui - cida, suicidio en jóvenes y variables psicosociales, consideradas por diferentes autores como facto - res de riesgo con base en los estudios realizados durante la última década en español. Para la revi - sión se consultaron las siguientes bases de datos: Dialnet, Redalyc, Scielo y Proquest. A partir de lo anterior se establecieron como predictores: suici - dio, ideación suicida, intento suicida y factores de riesgo. Con respecto a la inclusión de los artículos analizados se tuvo en cuenta que fueran artícu - los empíricos con población joven. Los estudios concentran su atención en la caracterización del fenómeno en los jóvenes latinoamericanos identi - ficando variables psicosociales asociadas como los problemas interpersonales en el contexto escolar, variables psicológicas, las exposición a situaciones de violencia intrafamiliar y abuso sexual, y final - mente los estilos y estrategias de afrontamiento desarrollados por los jóvenes. Se concluye que el suicidio es un fenómeno multicausal (Cabra, In - fante & Sossa, 2010 que va en aumento con la aparición de problemáticas propias de la sociedad actual, tales como el acoso escolar, los trastornos alimentarios, el abuso sexual y el maltrato. Cabe resaltar, que la población más vulnerable a este tipo de problemas siguen siendo los niños y los jó - venes (Barrera, Ordóñez, Palacios & Peña, 2007, lo que exige a los profesionales en salud mental generar estrategias de intervención orientadas a la identificación y prevención de las mismas.

  20. Prevention of Vascular Dysfunction after Preeclampsia: A Potential Long-Term Outcome Measure and an Emerging Goal for Treatment

    Directory of Open Access Journals (Sweden)

    Merzaka Lazdam

    2012-01-01

    Full Text Available Preeclampsia is increasingly being recognised as more than an isolated disease of pregnancy. In particular, preeclampsia has emerged as an independent risk factor for maternal cardiovascular disease and has recently been recognised as a risk factor for cardiovascular disease in children exposed in utero. Preeclampsia and cardiovascular disease may share important pathophysiological and molecular mechanisms and further investigation into these is likely to offer insight into the origins of both conditions. This paper considers the links between cardiovascular disease and preeclampsia and the implication of these findings for refinement of the management of patients whose care is complicated by preeclampsia.