WorldWideScience

Sample records for asme research committee

  1. Activated sludge models ASM1, ASM2, ASM2d and ASM3

    DEFF Research Database (Denmark)

    Henze, Mogens; Gujer, W.; Mino, T.;

    This book has been produced to give a total overview of the Activated Sludge Model (ASM) family at the start of 2000 and to give the reader easy access to the different models in their original versions. It thus presents ASM1, ASM2, ASM2d and ASM3 together for the first time.Modelling of activated...... sludge processes has become a common part of the design and operation of wastewater treatment plants. Today models are being used in design, control, teaching and research.ContentsASM3: Introduction, Comparison of ASM1 and ASM3, ASM3: Definition of compounds in the model, ASM3: Definition of processes...... in the Model, ASM3: Stoichiometry, ASM3: Kinetics, Limitations of ASM3, Aspects of application of ASM3, ASM3C: A Carbon based model, Conclusion ASM 2d: Introduction, Conceptual Approach, ASM 2d, Typical Wastewater Characteristics and Kinetic and Stoichiometric Constants, Limitations, Conclusion ASM 2...

  2. Using ASM Podcasts to Excite Undergraduate Students about Current Microbiological Research

    Directory of Open Access Journals (Sweden)

    Stacey E. Lettini

    2014-08-01

    Full Text Available Innovative technology is often used as a mechanism to engage students in and out of the classroom and can be used to increase critical thinking skills. Podcasts are an excellent way to introduce students to current topics and research in microbiology. The American Society for Microbiology (ASM produces three podcasts that are microbiologically focused: This Week in Microbiology (TWiM, This Week in Parasitology (TWiP, and This Week in Virology (TWiV. These podcasts are usually presented in a manner similar to a journal club, as the presenters regularly invite guests to discuss current research papers. Since students often find reading scientific literature difficult and get bogged down in the details rather than seeing the over-arching purpose of a paper, these podcasts have been used in a General Microbiology course to introduce recent research articles. The students were first assigned an original research article to read and review, and they were asked to generate questions pertaining to things they did not understand. Next, students listened to the corresponding podcast that discussed the article and used it to answer their questions. This was followed by a classroom discussion of the article and the podcast. The ASM podcast helped to demystify original research by providing details of the experimental design and presentation of the results in a language that is more casual and relatable. Students demonstrated greater critical thinking and comprehension of microbiology literature after listening to the podcast. This activity can be used in a variety of courses in the biology curriculum.

  3. Research ethics committees: agents of research policy?

    Directory of Open Access Journals (Sweden)

    Hemminki Elina

    2005-10-01

    Full Text Available Abstract The purpose of this commentary is to describe the unintended effects ethics committees may have on research and to analyse the regulatory and administrative problems of clinical trials. Discussion The Finnish law makes an arbitrary distinction between medical research and other health research, and the European Union's directive for good clinical trials further differentiates drug trials. The starting point of current rules is that clinical trials are lesser in the interest of patients and society than routine health care. However, commercial interests are not considered unethical. The contrasting procedures in research and normal health care may tempt physicians to continue introducing innovations into practice by relying on unsystematic and uncontrolled observations. Tedious and bureaucratic rules may lead to the disappearance of trials initiated by researchers. Trying to accommodate the special legislative requirements for new drug trials into more complex interventions may result in poor designs with unreliable results and increased costs. Meanwhile, current legal requirements may undermine the morale of ethics committee members. Conclusion The aims and the quality of the work of ethics committees should be evaluated, and a reformulation of the EU directive on good clinical trials is needed. Ethical judgement should consider the specific circumstance of each trial, and ethics committees should not foster poor research for legal reasons.

  4. The first twenty years of the ASME Committee on nuclear air and gas treatment - a retrospective by a founding member

    Energy Technology Data Exchange (ETDEWEB)

    Jacox, J. [Jacox Associates, Columbus, OH (United States)

    1997-08-01

    Since the 1996 Winter Meeting of CONAGT was the twentieth anniversary of CONAGT a review of the Committee and its members seems in order. This Paper will cover the background and formation of CONAGT as well as the history to date. This history will include not only the basic accomplishments but some of the less successfully met goals and a look at some of the personalities involved in the Committee work. General future plans will be included. The intent of the Paper is less a formal history than a personal recollection of the Committee and those who worked so hard to create the best possible Codes and Standards for the industry to use. 10 refs.

  5. 77 FR 16894 - Financial Research Advisory Committee

    Science.gov (United States)

    2012-03-22

    ... recognized experts in the fields of economics, financial institutions and markets, statistical analysis, financial markets analysis, econometrics, applied sciences, risk management, data, information standards... Financial Research Advisory Committee AGENCY: Office of Financial Research, Treasury. ACTION: Notice...

  6. Human research ethics committees in technical universities.

    Science.gov (United States)

    Koepsell, David; Brinkman, Willem-Paul; Pont, Sylvia

    2014-07-01

    Human research ethics has developed in both theory and practice mostly from experiences in medical research. Human participants, however, are used in a much broader range of research than ethics committees oversee, including both basic and applied research at technical universities. Although mandated in the United States, the United Kingdom, Canada, and Australia, non-medical research involving humans need not receive ethics review in much of Europe, Asia, Latin America, and Africa. Our survey of the top 50 technical universities in the world shows that, where not specifically mandated by law, most technical universities do not employ ethics committees to review human studies. As the domains of basic and applied sciences expand, ethics committees are increasingly needed to guide and oversee all such research regardless of legal requirements. We offer as examples, from our experience as an ethics committee in a major European technical university, ways in which such a committee provides needed services and can help ensure more ethical studies involving humans outside the standard medical context. We provide some arguments for creating such committees, and in our supplemental article, we provide specific examples of cases and concerns that may confront technical, engineering, and design research, as well as outline the general framework we have used in creating our committee.

  7. 78 FR 46331 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2013-07-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Biomass... for candidates to fill vacancies on the Biomass Research and Development Technical Advisory Committee...: http://biomassboard.gov/committee/committee.html . SUPPLEMENTARY INFORMATION: The Biomass Research...

  8. [Research ethics committees: a necessary good].

    Science.gov (United States)

    Riera, Alejandra V

    2013-12-01

    The Nuremberg Code, issued as the result of the deliberations of the Nuremberg Trials, which judged the atrocities carried out during Nazi Germany (1933-1945), was the first universal document that defined research ethics principles for human experimentation. This code served as the basis for the subsequent ethical codes and principles used today by the Research Ethics Committees. The Research Ethics Committee is a multidisciplinary body whose primary role is to protect the rights and welfare of research subjects through the review of research protocols, ensuring compliance with internationally and locally accepted ethical guidelines. Worldwide, there have been important improvements in order to promote and regulate bioethics in medical research. In Venezuela, several national organizations have been constituted with the aim of promoting the establishment of ethics committees; however, there has not been a significant progress in the quantity or quality of the functioning of Research Ethics Committees in the country. It is imperative for each research institution to establish and work to improve their ethics committee to ensure the quality of the clinical research conducted, making it adherent to ethical codes, and safeguarding the integrity and credibility of the investigators and the research institutions, and more importantly, the patient's rights.

  9. Sdz asm 981.

    Science.gov (United States)

    Wellington, K; Spencer, C M

    2000-12-01

    SDZ ASM 981 is an anti-inflammatory macrolactam which binds with high affinity to macrophilin-12. The resulting complex inhibits calcineurin, thus blocking the synthesis of inflammatory cytokines. Twice daily application of topical SDZ ASM 981 1% cream was effective in the treatment of atopic dermatitis in adults and children in clinical trials. Summarised results from 260 patients with atopic dermatitis indicate that the efficacy of SDZ ASM 981 is dose dependent. The highest concentration evaluated (1% cream) was not as effective as betamethasone valerate 1% cream in this 3-week trial. The efficacy of SDZ ASM 981 and clobetasol ointments, used under occlusion, did not differ significantly in 10 patients with chronic psoriasis. Likewise, SDZ ASM 981 0.6% and betamethasone valerate 1% creams were similarly effective in 66 patients with allergic contact dermatitis. Concentrations of SDZ ASM 981 in the blood during topical treatment were invariably below 2.1 microg/L. Oral SDZ ASM 981 20mg or 30mg twice daily were effective in a dose dependent manner in the reduction of psoriasis in adults with no evidence of adverse effects. SDZ ASM 981 was well tolerated in the available trials, exhibiting no potential for systemic adverse reactions and no atrophogenic potential, a problem commonly associated with corticosteroid treatment.

  10. [Why to audit to research ethics committees?].

    Science.gov (United States)

    Quiroz, Estela

    2010-09-01

    Ethics committees in biomedical research have the responsibility to ensure the protection of human participants in the studies. In order to improve the quality of their work they must undergo audit procedures commissioned by the sponsors and inspections done by the regulatory authorities. Through these procedures, improvement of their functions should be guaranteed, so they can optimize their tasks and accomplish in the best way the purpose for which they were created.

  11. ACOG committee opinion: ethical considerations in research involving women. Number 290, November 2003: Committee on Ethics.

    Science.gov (United States)

    2004-07-01

    In this Committee Opinion, the American College of Obstetricians and Gynecologists Committee on Ethics affirms both the need for women to serve as research participants and the obligation for researchers, institutional review boards, and others reviewing clinical research to evaluate the potential effect of proposed research on women of childbearing potential, pregnant women, and the developing fetus.

  12. ASME Code Efforts Supporting HTGRs

    Energy Technology Data Exchange (ETDEWEB)

    D.K. Morton

    2011-09-01

    In 1999, an international collaborative initiative for the development of advanced (Generation IV) reactors was started. The idea behind this effort was to bring nuclear energy closer to the needs of sustainability, to increase proliferation resistance, and to support concepts able to produce energy (both electricity and process heat) at competitive costs. The U.S. Department of Energy has supported this effort by pursuing the development of the Next Generation Nuclear Plant, a high temperature gas-cooled reactor. This support has included research and development of pertinent data, initial regulatory discussions, and engineering support of various codes and standards development. This report discusses the various applicable American Society of Mechanical Engineers (ASME) codes and standards that are being developed to support these high temperature gascooled reactors during construction and operation. ASME is aggressively pursuing these codes and standards to support an international effort to build the next generation of advanced reactors so that all can benefit.

  13. ASME Code Efforts Supporting HTGRs

    Energy Technology Data Exchange (ETDEWEB)

    D.K. Morton

    2010-09-01

    In 1999, an international collaborative initiative for the development of advanced (Generation IV) reactors was started. The idea behind this effort was to bring nuclear energy closer to the needs of sustainability, to increase proliferation resistance, and to support concepts able to produce energy (both electricity and process heat) at competitive costs. The U.S. Department of Energy has supported this effort by pursuing the development of the Next Generation Nuclear Plant, a high temperature gas-cooled reactor. This support has included research and development of pertinent data, initial regulatory discussions, and engineering support of various codes and standards development. This report discusses the various applicable American Society of Mechanical Engineers (ASME) codes and standards that are being developed to support these high temperature gascooled reactors during construction and operation. ASME is aggressively pursuing these codes and standards to support an international effort to build the next generation of advanced reactors so that all can benefit.

  14. ASME Code Efforts Supporting HTGRs

    Energy Technology Data Exchange (ETDEWEB)

    D.K. Morton

    2012-09-01

    In 1999, an international collaborative initiative for the development of advanced (Generation IV) reactors was started. The idea behind this effort was to bring nuclear energy closer to the needs of sustainability, to increase proliferation resistance, and to support concepts able to produce energy (both electricity and process heat) at competitive costs. The U.S. Department of Energy has supported this effort by pursuing the development of the Next Generation Nuclear Plant, a high temperature gas-cooled reactor. This support has included research and development of pertinent data, initial regulatory discussions, and engineering support of various codes and standards development. This report discusses the various applicable American Society of Mechanical Engineers (ASME) codes and standards that are being developed to support these high temperature gascooled reactors during construction and operation. ASME is aggressively pursuing these codes and standards to support an international effort to build the next generation of advanced reactors so that all can benefit.

  15. Research on the Formal Semantics of Verilog Based on ASM%Verilog语义的ASM表示方法研究

    Institute of Scientific and Technical Information of China (English)

    胡燕翔

    2006-01-01

    使用抽象状态机模型(ASM)对Verilog的语义进行研究,给出各类赋值语句和延迟/事件控制结构的形式定义.以此为基础与VHDL进行对比,说明各种赋值语句和延迟/事件控制结构向VHDL的转换方法以及二者在转换前后的差异.

  16. Paying Clinical Research Participants: One Institution's Research Ethics Committees' Perspective.

    Science.gov (United States)

    Ripley, Elizabeth B D; Macrina, Frank L; Markowitz, Monika

    2006-12-01

    REGULATORY GUIDELINES LEAVE determination of coercion and undue influence of research participants open to interpretation. A web-based survey was conducted of the research ethics committees members at Virginia Commonwealth University (VCU) to evaluate their perspectives on paying participants in clinical research via general questions, as well as 8 short cases involving hypertension placebo-controlled trials, a pilot exercise study, a survey of substance abusers, a healthy-volunteer pharmacokinetic study, a twin study involving DNA samples, and an asthma medication study in children. Research ethics committee members were asked to state what payment they would consider appropriate for a given type of protocol. The results suggest that risk, time required, reimbursement for expenses, and inconvenience were important in determining appropriate payment, while income and funding source were not. The case studies revealed wide variation in recommended payments both within type of study and between studies.

  17. 77 FR 42298 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2012-07-18

    ... Efficiency and Renewable Energy Biomass Research and Development Technical Advisory Committee AGENCY: Energy... Appointment as a Member of the Biomass Research and Development Technical Advisory Committee. SUMMARY: In... soliciting nominations for candidates to fill vacancies on the Biomass Research and Development...

  18. 76 FR 44648 - Research, Engineering and Development Advisory Committee

    Science.gov (United States)

    2011-07-26

    ..., DC on July 14, 2011. Paul Fontaine, Director (A), Research & Technology Development. BILLING CODE... Federal Aviation Administration Research, Engineering and Development Advisory Committee Pursuant to... given of a meeting of the FAA Research, Engineering and Development (R,E&D) Advisory Committee....

  19. 76 FR 12404 - Research, Engineering and Development Advisory Committee

    Science.gov (United States)

    2011-03-07

    ..., DC, on February 24, 2011. Paul Fontaine, Director (A), Research & Technology Development. BILLING... Federal Aviation Administration Research, Engineering and Development Advisory Committee Pursuant to... given of a meeting of the FAA Research, Engineering and Development (R,E&D) Advisory Committee....

  20. 75 FR 45130 - Guidance for Industry and Researchers on the Radioactive Drug Research Committee: Human Research...

    Science.gov (United States)

    2010-08-02

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Researchers on the Radioactive Drug Research Committee: Human Research Without an Investigational New Drug Application; Availability... the availability of a draft guidance for industry and researchers entitled ``The Radioactive...

  1. 78 FR 44105 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2013-07-23

    ... Efficiency and Renewable Energy Biomass Research and Development Technical Advisory Committee AGENCY: Energy... announces an open meeting of the Biomass Research and Development Technical Advisory Committee. The Federal... contact (Departments of Energy and Agriculture) with respect to the Biomass R&D Initiative...

  2. 75 FR 74026 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2010-11-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Biomass... meeting of the Biomass Research and Development Technical Advisory Committee under Section 9008(d) of the... meeting of the Biomass Research and Development Technical Advisory Committee. DATES: December 15, 2010...

  3. 76 FR 22091 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2011-04-20

    ... Efficiency and Renewable Energy Biomass Research and Development Technical Advisory Committee AGENCY: Energy... announces an open meeting of the Biomass Research and Development Technical Advisory Committee. The Federal... products. Tentative Agenda: Agenda will include the following: Update on USDA Biomass R&D Activities...

  4. 77 FR 26276 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2012-05-03

    ... Efficiency and Renewable Energy Biomass Research and Development Technical Advisory Committee AGENCY: Energy... announces an open meeting of the Biomass Research and Development Technical Advisory Committee. The Federal... products. Tentative Agenda: Agenda will include the following: Update on USDA Biomass R&D Activities...

  5. Cisco ASM Router

    CERN Multimedia

    2001-01-01

    One of the two "ASM/2-32EM" boxes installed in 1988, from "Cisco Systems Inc." - then an unknown 20-employee company in Menlo Park, California (USA). This is one of the first two Cisco boxes to appear in Switzerland, and possibly Europe. The 220v power supply was a special modification made for use at CERN. They supported IP address filtering, which seemed just what CERN needed to help protect the new Cray XMP-48 super computer from network hackers. The two ASM boxes were both routers and terminal servers. They protected a secure private Ethernet segment used by the Cray project, as well as providing secure terminal connections to that segment, including CERN's first dialback terminal service, which allowed Cray and CERN system analysts to work on the machine from home, using another Cisco feature called TACACS. (Kindly offered by B. Segal who discovered this company while at a Usenix Conference in Phoenix, Arizona in June 1987.)

  6. 78 FR 6087 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2013-01-29

    ... Biological and Environmental Research Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Biological and.... Department of Energy, Office of Science, Office of Biological and Environmental Research,...

  7. 77 FR 4028 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2012-01-26

    ... Biological and Environmental Research Advisory Committee AGENCY: Department of Energy; Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Biological and... of Biological and Environmental Research, SC-23/Germantown Building, 1000 Independence Avenue...

  8. 77 FR 6791 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2012-02-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Biomass... Biomass Research and Development Technical Advisory Committee. The Federal Advisory Committee Act requires... production of biobased fuels and biobased products. Tentative Agenda Update on USDA Biomass R&D...

  9. 78 FR 34088 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2013-06-06

    ... Biological and Environmental Research Advisory Committee AGENCY: Office of Science, Department of Energy... Office of Biological and Environmental Research News from the Biological Systems Science and Climate and..., Office of Science, Office of Biological and Environmental Research, SC-23/Germantown Building, 1000...

  10. 75 FR 6651 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2010-02-10

    ... Biological and Environmental Research Advisory Committee AGENCY: Department of Energy; Office of Science... the Office of Biological and Environmental Research News From the Biological Systems Science and.... David Thomassen, Designated Federal Officer, BERAC, U.S. Department of Energy, Office of Science, Office...

  11. 75 FR 56525 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2010-09-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Biomass... meeting of the Biomass Research and Development Technical Advisory Committee under Section 9008(d) of the... participation. This notice announces the meeting of the Biomass Research and Development Technical...

  12. 75 FR 30804 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2010-06-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Biomass... meeting of the Biomass Research and Development Technical Advisory Committee under Section 9008(d) of the... participation. This notice announces the meeting of the Biomass Research and Development Technical...

  13. 75 FR 11526 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2010-03-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Biomass... meeting of the Biomass Research and Development Technical Advisory Committee under Section 9008(d) of the... participation. This notice announces the meeting of the Biomass Research and Development Technical...

  14. 78 FR 64932 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2013-10-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Biomass... Biomass Research and Development Technical Advisory Committee under Section 9008(d) of the Food.... This notice announces the meeting of the Biomass Research and Development Technical Advisory...

  15. Safety Analysis Report for the KRI-ASM Transport Package

    Energy Technology Data Exchange (ETDEWEB)

    Bang, K. S.; Lee, J. C.; Kim, D. H.; Seo, K. S

    2006-10-15

    Safety evaluation for the KRI-ASM transport package to transport safely I-131, which is produced at HANARO research reactor in KAERI, was carried out. In the safety analyses results for the KRI-ASM transport package, all the maximum stresses as well as the maximum temperature of the surface are lower than their allowable limits. The safety tests to verify the safety analyses results will be performed by using the test model of the KRI-BGM transport package.

  16. Recurring themes arising during medical research ethics committee review.

    Science.gov (United States)

    Kelleher, E; Stanton, A; Vale, G; Smith, D

    2013-06-01

    A standard application form for the ethical review of health-related research studies has recently been adopted by many Irish medical research ethics committees. In order to assess the impact of the new form, we reviewed all comments made by the Beaumont Hospital Ethics Committee during two six-month periods, immediately prior to adoption of the new form (2010), and soon afterwards (2011). Neither volume nor comment type differed significantly between the two observation periods. Participant documentation (information leaflets and consent forms) accounted for the largest proportion of comments (2010; 44%, 2011; 37%). Other common areas prompting queries were study administration (7%), design (12%) and procedures (13%), participant selection and recruitmen (8%), and lastly data protection (9%). Because of these findings, the standard operating procedures of the committee have been revised--use of provided template participant documentation is strongly encouraged, and a "Recurring Review Themes" checklist is highlighted to all applicants.

  17. Payment of research participants: current practice and policies of Irish research ethics committees.

    LENUS (Irish Health Repository)

    Roche, Eric

    2013-09-01

    Payment of research participants helps to increase recruitment for research studies, but can pose ethical dilemmas. Research ethics committees (RECs) have a centrally important role in guiding this practice, but standardisation of the ethical approval process in Ireland is lacking.

  18. 75 FR 48411 - Research, Engineering and Development Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-08-10

    .... Barry Scott, Director, Research & Technology Development. BILLING CODE 4910-13-M ... Federal Aviation Administration Research, Engineering and Development Advisory Committee; Notice of... of a meeting of the FAA Research, Engineering and Development (R, E&D) Advisory Committee....

  19. 76 FR 8357 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2011-02-14

    ... Biological and Environmental Research Advisory Committee AGENCY: Department of Energy; Office of Science... News from the Biological Systems Science and Climate and Environmental Sciences Divisions Discussions...) 903-9817; fax (301) 903-5051 or e-mail: david.thomassen@science.doe.gov . The most current information...

  20. Significant issues and changes for ANSI/ASME OM-1 1981, part 1, ASME OMc code-1994, and ASME OM Code-1995, Appendix I, inservice testing of pressure relief devices in light water reactor power plants

    Energy Technology Data Exchange (ETDEWEB)

    Seniuk, P.J.

    1996-12-01

    This paper identifies significant changes to the ANSI/ASME OM-1 1981, Part 1, and ASME Omc Code-1994 and ASME OM Code-1995, Appendix I, {open_quotes}Inservice Testing of Pressure Relief Devices in Light-Water Reactor Power Plants{close_quotes}. The paper describes changes to different Code editions and presents insights into the direction of the code committee and selected topics to be considered by the ASME O&M Working Group on pressure relief devices. These topics include scope issues, thermal relief valve issues, as-found and as-left set-pressure determinations, exclusions from testing, and cold setpoint bench testing. The purpose of this paper is to describe some significant issues being addressed by the O&M Working Group on Pressure Relief Devices (OM-1). The writer is currently the chair of OM-1 and the statements expressed herein represents his personal opinion.

  1. Committees

    Science.gov (United States)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  2. 78 FR 42805 - NASA Advisory Council; Human Exploration Operations Committee; Research Subcommittee; Meeting

    Science.gov (United States)

    2013-07-17

    ... SPACE ADMINISTRATION NASA Advisory Council; Human Exploration Operations Committee; Research... Aeronautics and Space Administration (NASA) announces a meeting of the Research Subcommittee of the Human Exploration and Operations Committee (HEOC) of the NASA Advisory Council (NAC). This Subcommittee reports...

  3. Stating the Case for Nursing Research Ethics Committees: A Discussion Paper.

    Science.gov (United States)

    Mitchell, Theresa; Fletcher, Ian

    1998-01-01

    Nurse-led research ethics committees are generally more tolerant of diversity in research proposals than are medical committees steeped in empirical traditions. However, national trends in nursing in Britain may influence a preference for multidisciplinary over nurse-led committees. (SK)

  4. 76 FR 36231 - American Society of Mechanical Engineers (ASME) Codes and New and Revised ASME Code Cases

    Science.gov (United States)

    2011-06-21

    ... Engineers (ASME) Codes and New and Revised ASME Code Cases; Final Rule #0;#0;Federal Register / Vol. 76 , No... 50 RIN 3150-AI35 American Society of Mechanical Engineers (ASME) Codes and New and Revised ASME Code... 2004 ASME Boiler and Pressure Vessel Code, Section III, Division 1; 2007 ASME Boiler and...

  5. Status Report [Air Pollution Research Advisory Committee of the Coordinating Research Council].

    Science.gov (United States)

    Coordinating Research Council, New York, NY. Air Pollution Research Advisory Committee.

    Research projects sponsored by the Coordinating Research Council, Air Pollution Research Advisory Committee, and dealing with vehicle emissions and their wide ranging effects on the environment are compiled in this status report. Spanning the range of problems associated with reducing emissions, they are divided into three main areas of research:…

  6. Ethical aspects in tissue research: thematic analysis of ethical statements to the research ethics committee

    Science.gov (United States)

    2012-01-01

    Background Many studies have been published about ethics committees and the clarifications requested about the submitted applications. In Finland, ethics committees require a separate statement on ethical aspects of the research in applications to the ethics committee. However, little is known about how researchers consider the ethical aspects of their own studies. Methods The data were collected from all the applications received by the official regional ethics committee in the Hospital District of Northern Savo during 2004–2009 (n = 688). These included a total of 56 studies involving research on tissue other than blood. The statements by the researchers about the ethics about their own research in these applications were analyzed by thematic content analysis under the following themes: recruitment, informed consent, risks and benefits, confidentiality and societal meaning. Results The researchers tended to describe recruitment and informed consent process very briefly. Usually these descriptions simply stated who the recruiter was and that written consent would be required. There was little information provided on the recruitment situation and on how the study recruiters would be informed. Although most of the studies were clinical, the possibility was hardly ever discussed that patients could fail to distinguish between care and research. Conclusion The written guidelines, available on the webpages of the ethics committee, do not seem to be enough to help researchers achieve this goal. In addition to detailed guidelines for researchers, investigators need to be taught to appreciate the ethical aspects in their own studies. PMID:22873761

  7. Research ethics committee auditing: the experience of a university hospital.

    Science.gov (United States)

    Marchetti, Daniela; Spagnolo, Angelico; Cicerone, Marina; Cascini, Fidelia; La Monaca, Giuseppe; Spagnolo, Antonio G

    2013-09-01

    The authors report the first Italian experience of a research ethics committee (REC) audit focused on the evaluation of the REC's compliance with standard operating procedures, requirements in insurance coverage, informed consent, protection of privacy and confidentiality, predictable risks/harms, selection of subjects, withdrawal criteria and other issues, such as advertisement details and justification of placebo. The internal audit was conducted over a two-year period (March 2009-February 2011) divided into quarters to better value the influence of the new insurance coverage regulation that came into effect in March 2010 (Ministerial Decree of 14 July, 2009) and expand the requirements to safeguard participants in clinical drug trials including other critical items as information and consent and the risks to benefits ratio. Out of a total of 639 REC's opinions and research studies, 316 were reviewed. Regarding the insurance policy requirements, Auditor/REC non-compliance occurred only in one case. The highest number of Auditor/REC non-compliance was in regard to information and consent, which should have incurred a suspended decision rather than a favorable opinion. This internal audit shows the importance and the difficulty of the review process. For this reason, specific courses for members of the research ethics committee and for those who aspire to become auditors will be provided. There may also be efforts to improve the standard operating procedures already in place.

  8. 75 FR 64321 - Interagency Coordinating Committee on Oil Pollution Research (ICCOPR); Public Meeting

    Science.gov (United States)

    2010-10-19

    ... Interagency Committee is coordinating an update of the Technology Plan during the next two fiscal years. Tentative Meeting Agenda The agenda for the November 17, 2010 Committee meeting is as follows: (1) 9 a.m... Biennial Report The Interagency Coordinating Committee on Oil Pollution Research Biennial Report for...

  9. 77 FR 31677 - Request for Public Comment on Interagency Arctic Research Policy Committee (IARPC) Arctic...

    Science.gov (United States)

    2012-05-29

    ... TECHNOLOGY POLICY Request for Public Comment on Interagency Arctic Research Policy Committee (IARPC) Arctic... and Policy Act of 1984 (ARPA), Public Law 98-373, established the Interagency Arctic Research Policy Committee (IARPC) to develop national Arctic research policy five-year Federal research plans to...

  10. Regulatory and Financial Reform of Federal Research Policy: Recommendations to the NRC Committee on Research Universities

    Science.gov (United States)

    Association of American Universities, 2011

    2011-01-01

    At the request of the National Research Council (NRC) Committee on Research Universities, the Council on Governmental Relations (COGR), the Association of American Universities (AAU), and the Association of Public and Land-grant Universities (APLU) have assembled a set of ten recommendations for regulatory reform that would improve research…

  11. Delays and diversity in the practice of local research ethics committees.

    OpenAIRE

    Ahmed, A. H.; Nicholson, K. G.

    1996-01-01

    OBJECTIVES: To compare the practices of local research ethics committees and the time they take to obtain ethical approval for a multi-centre study. DESIGN: A retrospective analysis of outcome of applications for a multi-centre study to local research ethics committees. SETTING: Thirty-six local research ethics committees covering 38 district health authorities in England. MAIN MEASURES: Response of chairmen and women, the time required to obtain approval, and questions asked in application f...

  12. Ethics committees and externally - sponsored research in Iran

    Directory of Open Access Journals (Sweden)

    Bagher Larijani

    2006-03-01

    Full Text Available Globally, there have been considerable debates on the ethical conduct and review of collaborative international researches. One of the great challenges is to conduct clinical trials in developing countries as Externally-Sponsored Researches (ESR. "nThis descriptive survey has reviewed the status of this type of researches in Iran during 2002 to 2003. This study was carried out in 44 universities of medical sciences and 32 research centers. The questionnaires containing closed and open-ended questions were sent to their Ethics Review Committees (ECs. After collection of data and coding, they were analyzed by means of SPSS software version 11.5. "nForty one universities and 25 research centers have been responded but only 35 ECs retrieved the questionnaire. According to the collected data, 26 and 54 studies have been carried out as a collaborative research or externally-sponsored researches in Iran in 2002 and 2003, respectively. Although more than half of ECs' members have received necessary preliminary educations but there were professional educational courses in only 25% of ECs. About 17% of ESR projects have not been examined in ECs, although they have been evaluated in the Scientific Research Council. Only one of the evaluated ESR proposals has been rejected and the rest have been approved and conducted. Socio-cultural issues and religious beliefs, scientific validity, and national priorities were the most important factors for proposals evaluation. "nThe ethical issues concerning international collaboration for clinical research in developing countries are complex. We should enhance educational programs for researchers and establish appropriate regulatory guidelines at national and international levels.

  13. 75 FR 59720 - Methodology Committee of the Patient-Centered Outcomes Research Institute (PCORI)

    Science.gov (United States)

    2010-09-28

    ... OFFICE Methodology Committee of the Patient-Centered Outcomes Research Institute (PCORI) AGENCY... appointing not more than 15 members to a Methodology Committee of the Patient- Centered Outcomes Research Institute. In addition, the Directors of the Agency for Healthcare Research and Quality and the...

  14. 12th Meeting of China-Korea Joint Committee for Basic Scientific Research Held

    Institute of Scientific and Technical Information of China (English)

    Zhang Yongtao

    2008-01-01

    @@ The 12th Meeting of the China-Korea Joint Committee for Basic Scientific Research was successfully held in Xiamen,China from May 21 to 24,2008.Through evaluation,the Joint Committee selected 37 bilateral cooperative projects to grant in FY 2008,including 12 joint seminars and 25 joint research projects.The Committee members also made in-depth discussions on the issues of strengthening future cooperation and selecting the topics for the Northeastern Asian Symposium.

  15. 76 FR 36102 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2011-06-21

    ... or physical handicap, marital status, or sexual orientation. To ensure that recommendations of the..., duties, terms, and membership types. The Committee must meet quarterly and should not duplicate...

  16. 76 FR 46781 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2011-08-03

    ... under Section 9008(d) of the Food, Conservation, and Energy Act of 2008. The Federal Advisory Committee...; Presentation on Genetically Modified Organism (GMO) regulations; Presentation on Greenhouse Gases,...

  17. 78 FR 38846 - Potato Research and Promotion Plan; Amend the Administrative Committee Structure and Delete the...

    Science.gov (United States)

    2013-06-28

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 1207 Potato Research and Promotion Plan... of the Administrative Committee (Committee) of the U.S. Potato Board (Board) and deleting the Board's mailing address from the Potato Research and Promotion Plan. The Plan is administered by the Board...

  18. 78 FR 36309 - Research Advisory Committee on Gulf War Veterans' Illnesses, Notice of Meeting

    Science.gov (United States)

    2013-06-17

    ... diagnosing and treating Gulf War Veterans, and a drug treatment trial which is underway. On June 18, the... AFFAIRS Research Advisory Committee on Gulf War Veterans' Illnesses, Notice of Meeting The Department of... Research Advisory Committee on Gulf War Veterans' Illnesses will meet on June 17 and 18, 2013, in room...

  19. Committees

    Science.gov (United States)

    2003-08-01

    Born in Buenos Aires, Argentina, in 1930, Alberto Sirlin studied at the University of Buenos Aires from 1948-52, where he carried out research work in classical nonlinear physics, under the guidance of Richard Gans, and in 1953 received the degree of doctor in Physical-Mathematical Sciences. In 1953 he held a fellowship at the Centro Brasileiro de Pesquisas Fisicas in Rio de Janeiro, Brazil, where he did research work and attended some graduate courses, including a memorable and highly influential one taught by Richard Feynman. He spent the academic year 1954-55 at UCLA, where he initiated his work on electroweak physics in collaboration with Robert Finkelstein and Ralph Behrends. His next move was to Cornell University in 1955, earning his PhD there in 1958 for research in electroweak physics in collaboration with Toichiro Kinoshita. Sirlin spent 1957-59 as a research associate at Columbia University, becoming an Assistant Professor of Physics at New York University in 1959, an Associate Professor in 1961, and a full Professor in 1968. It is a remarkable coincidence that one of his fellow post-docs, Steven Weinberg, was to become one of the founders of the Standard Model, which in turn has provided the natural setting for Sirlin's work. During his formative years, he was extremely fortunate to receive guidance and advice from an extraordinary group of distinguished scientists, including R Gans, R P Feynman, R J Finkelstein, H A Bethe and E E Salpeter. He also enjoyed close and fruitful long-term collaborations with a number of brilliant theorists, including R E Behrends, T Kinoshita, T D Lee, M A B Beg, W J Marciano, P Langacker, G Degrassi, P Gambino and B A Kniehl, and has had fourteen excellent, interesting, and highly enterprising graduate students, who have remained close friends. Sirlin's main research interests have been in precision electroweak physics, other topics in weak interaction theory, the search for higher symmetries of the strong interactions

  20. ASME Evaluation on Grid Mobile E-Commerce Process

    OpenAIRE

    Dan Chang; Wei Liao

    2012-01-01

    With the development of E-commerce, more scholars have paid attention to research on Mobile E-commerce and mostly focus on the optimization and evaluation of existing process. This paper researches the evaluation of Mobile E-commerce process with a method called ASME. Based on combing and analyzing current mobile business process and utilizing the grid management theory, mobile business process based on grid are constructed. Firstly, the existing process, namely Non-grid Mobile E-commerce, an...

  1. ASME Evaluation on Grid Mobile E-Commerce Process

    OpenAIRE

    Dan Chang; Wei Liao

    2012-01-01

    With the development of E-commerce, more scholars have paid attention to research on Mobile E-commerce and mostly focus on the optimization and evaluation of existing process. This paper researches the evaluation of Mobile E-commerce process with a method called ASME. Based on combing and analyzing current mobile business process and utilizing the grid management theory, mobile business process based on grid are constructed. Firstly, the existing process, namely Non-grid Mobile E-commerce, an...

  2. A cross-sectional survey to investigate community understanding of medical research ethics committees.

    Science.gov (United States)

    Fritschi, Lin; Kelsall, Helen L; Loff, Bebe; Slegers, Claudia; Zion, Deborah; Glass, Deborah C

    2015-07-01

    Study explanatory forms often state that an ethics committee has approved a research project. To determine whether the lay community understand the roles of ethics committees in research, we took a cross-sectional national sample from three sampling frames: the general population (n=1532); cohort study participants (n=397); and case-control study participants (n=151). About half (51.3%) of the participants had heard of ethics committees. Those who had were more likely to be those who had participated in previous surveys, older participants, those born in Australia and those with higher education. Almost all participants agreed that the roles of an ethics committee were to protect participants' privacy and ensure no harm came to study participants and most agreed that the committee's role was to ensure that the research was capable of providing answers. Case-control and cohort participants were more likely than the general population to consider that the role of an ethics committee was to design the research and obtain research funding. Overall, we found that about half of the population are aware of ethics committees and that most could correctly identify that ethics committees are there to protect the welfare and rights of research participants, although a substantial minority had some incorrect beliefs about the committees' roles. Increased education, particularly for migrants and older people, might improve understanding of the role of ethics committees in research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  3. ASME BPE专家访谈

    Institute of Scientific and Technical Information of China (English)

    王欣

    2009-01-01

    ASME BPE,这一串字符对于药品生产商和设备供应商来说意味着什么?这是否是开启生物制药大门的成功密钥?本刊特邀ASME BPE委员会现任委员、资深专家为您详细破译。

  4. Research Ethics Committees and Participatory Action Research With Young People: The Politics of Voice.

    Science.gov (United States)

    Yanar, Zeynep M; Fazli, Mehria; Rahman, Jahanara; Farthing, Rys

    2016-04-01

    Participatory action research (PAR) is a methodological approach that seeks to maximize the participation of people whose lives it researches. It is underpinned by an ethical concern to research "with" people, rather than "on" people. However, this ethical approach to research is often, paradoxically, problematized by universities' research ethics committees (RECs). This article explores one site of tension between PAR and RECs-the requirement for anonymity for below 18-year-olds. It explores this tension by exploring a case study of a peer-to-peer research project undertaken by young women in East London, and using our own experiences and perspectives, it argues that anonymity can be unjust, disempowering, and unnecessary, and can reduce "pride." Without wanting to develop specific recommendations, given the limited scope of our case study, this article uses firsthand experiences to add weight to the broader discussions calling for a critical rethink of REC guidelines.

  5. 75 FR 20618 - Interagency Coordinating Committee on Oil Pollution Research (ICCOPR); Public Meeting

    Science.gov (United States)

    2010-04-20

    ... the Technology Plan during the next two fiscal years. Tentative Meeting Agenda The agenda for the May... Coordinating Committee on Oil Pollution Research Biennial Report for Fiscal Years 2008 and 2009, which will...

  6. A syllabus for research ethics committees: training needs and resources in different European countries.

    Science.gov (United States)

    Cairoli, Ester; Davies, Hugh T; Helm, Jürgen; Hook, Georg; Knupfer, Petra; Wells, Frank

    2012-03-01

    This paper reports a European Forum for Good Clinical Practice workshop held in 2011 to consider a research ethics committee training syllabus, subsequent training needs and resources. The syllabus that was developed was divided into four competencies: committee working; scientific method; ethical analysis and the regulatory framework. Appropriate training needs for each, with possible resources, were discussed. Lack of funding for training was reported as a major problem but affordable alternatives were debated. Strengths and weaknesses of this approach were discussed and the resultant proposal will be disseminated through the European Forum for Good Clinical Practice and the research ethics committees of member states.

  7. [Institutional ethics committees in Mexico: the ambiguous boundary between health care ethics and research ethics].

    Science.gov (United States)

    Valdez-Martínez, Edith; Lifshitz-Guinzberg, Alberto; Medesigo-Micete, José; Bedolla, Miguel

    2008-08-01

    To identify ethics committees in medical practice in Mexico and possible implications stemming from their composition and functions. A cross-sectional descriptive study was conducted from January-December 2005. A survey was sent by e-mail to the hospitals and family medicine centers with at 10 practices within the Mexican Institute for Social Security (Instituto Mexicano del Seguro Social) (n=437) and the Institute for Security and Social Services for State Employees (Seguridad y Servicios Sociales de los Trabajadores del Estado) (n=167) and to the Mexican Ministry of Health's most important health care centers (n=15). The following items were analyzed: name of the committee, date of formation, current status, composition, functions, and level of authority. In all, 116 committees were identified, with various names. Of these, 101 (87.1%) were active. The committees were formed from 1985-2006, with a spike occurring in 2004-2005. Of the active committees, 59 (58.4%) were charged with ethical problems/dilemmas related to clinical practice as well as those related to research projects. Of the committee members, 357 (59.0%) held managing positions in the establishment to which the committee pertained; most were medical professionals (71.5%), followed by nursing staff (11.9%). Among the members of the active committees, 77.9% had not received training in ethics. Legal conflicts can be expected, mainly within the organizations whose committees have the authority to determine a course of action. An integrated plan is needed that will set standards for the composition and proceedings of Mexico's ethics committees and the improved training of committee members.

  8. Protecting vulnerable research participants: a Foucault-inspired analysis of ethics committees.

    Science.gov (United States)

    Juritzen, Truls I; Grimen, Harald; Heggen, Kristin

    2011-09-01

    History has demonstrated the necessity of protecting research participants. Research ethics are based on a concept of asymmetry of power, viewing the researcher as powerful and potentially dangerous and establishing ethics committees as external agencies in the field of research. We argue in favour of expanding this perspective on relationships of power to encompass the ethics committees as one among several actors that exert power and that act in a relational interplay with researchers and participants. We employ Michel Foucault's ideas of power as an omnipresent force which is dynamic and unstable, as well as the notion that knowledge and power are inextricably intertwined. The article discusses how research ethics committees may affect academic freedom. In addition it is pointed out that research participants could be harmed - not only by unfortunate research practices, but also by being subjected to the protective efforts of ethics monitoring bodies.

  9. ASME Material Challenges for Advanced Reactor Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Piyush Sabharwall; Ali Siahpush

    2013-07-01

    This study presents the material Challenges associated with Advanced Reactor Concept (ARC) such as the Advanced High Temperature Reactor (AHTR). ACR are the next generation concepts focusing on power production and providing thermal energy for industrial applications. The efficient transfer of energy for industrial applications depends on the ability to incorporate cost-effective heat exchangers between the nuclear heat transport system and industrial process heat transport system. The heat exchanger required for AHTR is subjected to a unique set of conditions that bring with them several design challenges not encountered in standard heat exchangers. The corrosive molten salts, especially at higher temperatures, require materials throughout the system to avoid corrosion, and adverse high-temperature effects such as creep. Given the very high steam generator pressure of the supercritical steam cycle, it is anticipated that water tube and molten salt shell steam generators heat exchanger will be used. In this paper, the ASME Section III and the American Society of Mechanical Engineers (ASME) Section VIII requirements (acceptance criteria) are discussed. Also, the ASME material acceptance criteria (ASME Section II, Part D) for high temperature environment are presented. Finally, lack of ASME acceptance criteria for thermal design and analysis are discussed.

  10. Understanding the structure and practices of research ethics committees through research and audit: a study from Mexico.

    Science.gov (United States)

    Valdez-Martinez, Edith; Trumbull, Bernardo; Garduño-Espinosa, Juan; Porter, John David Henley

    2005-09-28

    This paper reports on a series of studies that were conducted at the Mexican Institute of Social Security (IMSS) between 2001 and 2002 to determine the role, structure and workings of their local research ethics committees (LRECs). The IMSS, unlike other Mexican health institutions, has a formal system of committees. Such committees operate under a regulatory system and are charged with scrutinising all research proposals in order to ensure their scientific validity and to protect the rights and well being of research subjects [Instituto Mexicano del Seguro Social. Dirección de Prestaciones Médicas (México). Manual de Investigación Médica en el IMSS: Instituto Mexicano del Seguro Social; 1999]. The organisation wanted to know how the committees were functioning and if the work of the committees needed to be improved. The problems that were encountered included issues with the composition of the committees, the process of project assessment, the continuing review process, and a lack of motivation of staff. In addition a qualitative study [Valdez-Martínez E, Turnbull B, Garduño-Espinosa J, Porter JDH. Descriptive ethics: a qualitative study of local research ethics committees in Mexico, Developing World Bioethics, 2005, in press] highlighted the focus of the committees on rules, regulations and the law with little understanding of the important individual role of members in complementing and adding to these structures and perspectives. The paper suggests that, to support staff and to protect research subjects, the organizational structure, management and decision making process of the IMSS's LRECs ought to be assessed regularly through audit cycles. In order to support the further development of the committees, the aim of the audit cycles should be focused on education and development of the vision, perspectives, values, and working processes of each LREC.

  11. Ethical assessment of research protocols: the experience of the Research Ethics Committee of the Hospital Israelita Albert Einstein (HIAE

    Directory of Open Access Journals (Sweden)

    Sonia Maria Oliveira de Barros

    2005-03-01

    Full Text Available This is a review article on the origin of the ethical analysis ofresearch protocols, the Brazilian and International legislation,including the Research Ethics Committee of Hospital IsraelitaAlbert Einstein. Since 1997, when the Committee was validatedits role has been recognized as that of a consultant and educator,participating on local and national scientific events andcollaborating with researchers in order to improve their projectsand learn to recognize ethical dilemmas in their protocols.

  12. Final report of the Committee on Interagency Radiation Research and Policy Coordination, 1984-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This document is the final report of the Committee on Interagency Radiation Research and Policy Coordination (CIRRPC). The committee was established to address national and international issues involving ionizing and nonionizing radiation. Three sections are included in the report: a summary of CIRRPC`s history structure, and operations; CIRRPC`s most significant activities, findings and recommendations on national radiation issues of sufficient importance and scope to require interagency attention; topics for future consideration by Federal agencies.

  13. 78 FR 20696 - NASA Advisory Council; Human Exploration and Operations Committee; Research Subcommittee; Meeting

    Science.gov (United States)

    2013-04-05

    ... SPACE ADMINISTRATION NASA Advisory Council; Human Exploration and Operations Committee; Research... and fact-finding with respect to the research activities within the Human Exploration and Operations... Aeronautics and Space Administration (NASA) announces a meeting of the Research Subcommittee of the Human...

  14. Improvement of ASME NH for Grade 91

    Energy Technology Data Exchange (ETDEWEB)

    Bernard Riou

    2007-10-09

    This report has been prepared in the context of Task 3 of the ASME/DOE Gen IV material project. It has been identified that creep-fatigue evaluation procedures presently available in ASME (1) and RCC-MR (2) have been mainly developed for austenitic stainless steels and may not be suitable for cyclic softening materials such as mod 9 Cr 1 Mo steel (grade 91). The aim of this document is, starting from experimental test results, to perform a review of the procedures and, if necessary, provide recommendations for their improvements.

  15. Human Participants in Engineering Research: Notes from a Fledgling Ethics Committee.

    Science.gov (United States)

    Koepsell, David; Brinkman, Willem-Paul; Pont, Sylvia

    2015-08-01

    For the past half-century, issues relating to the ethical conduct of human research have focused largely on the domain of medical, and more recently social-psychological research. The modern regime of applied ethics, emerging as it has from the Nuremberg trials and certain other historical antecedents, applies the key principles of: autonomy, respect for persons, beneficence, non-maleficence, and justice to human beings who enter trials of experimental drugs and devices (Martensen in J Hist Med Allied Sci 56(2):168-175, 2001). Institutions such as Institutional Review Boards (in the U.S.) and Ethics Committees (in Europe and elsewhere) oversee most governmentally-funded medical research around the world, in more than a hundred nations that are signers of the Declaration of Helsinki (World Medical Association 2008). Increasingly, research outside of medicine has been recognized to pose potential risks to human subjects of experiments. Ethics committees now operate in the US, Canada, the U.K. and Australia to oversee all governmental-funded research, and in other jurisdictions, the range of research covered by such committees is expanding. Social science, anthropology, and other fields are falling under more clear directives to conduct a formal ethical review for basic research involving human participants (Federman et al. in Responsible research: a systems approach to protecting research participants. National Academies Press, Washington, 2003, p. 36). The legal and institutional response for protecting human subjects in the course of developing non-medical technologies, engineering, and design is currently vague, but some universities are establishing ethics committees to oversee their human subjects research even where the experiments involved are non-medical and not technically covered by the Declaration of Helsinki. In The Netherlands, as in most of Europe, Asia, Latin America, or Africa, no laws mandate an ethical review of non-medical research. Yet, nearly 2

  16. PHASE I MATERIALS PROPERTY DATABASE DEVELOPMENT FOR ASME CODES AND STANDARDS

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL; Lin, Lianshan [ORNL

    2013-01-01

    To support the ASME Boiler and Pressure Vessel Codes and Standard (BPVC) in modern information era, development of a web-based materials property database is initiated under the supervision of ASME Committee on Materials. To achieve efficiency, the project heavily draws upon experience from development of the Gen IV Materials Handbook and the Nuclear System Materials Handbook. The effort is divided into two phases. Phase I is planned to deliver a materials data file warehouse that offers a depository for various files containing raw data and background information, and Phase II will provide a relational digital database that provides advanced features facilitating digital data processing and management. Population of the database will start with materials property data for nuclear applications and expand to data covering the entire ASME Code and Standards including the piping codes as the database structure is continuously optimized. The ultimate goal of the effort is to establish a sound cyber infrastructure that support ASME Codes and Standards development and maintenance.

  17. 78 FR 37848 - ASME Code Cases Not Approved for Use

    Science.gov (United States)

    2013-06-24

    ... COMMISSION ASME Code Cases Not Approved for Use AGENCY: Nuclear Regulatory Commission. ACTION: Draft... public comment draft regulatory guide (DG), DG-1233, ``ASME Code Cases not Approved for Use.'' This regulatory guide lists the American Society of Mechanical Engineers (ASME) Code Cases that the NRC...

  18. Activated sludge model No. 2d, ASM2d

    DEFF Research Database (Denmark)

    Henze, M.

    1999-01-01

    The Activated Sludge Model No. 2d (ASM2d) presents a model for biological phosphorus removal with simultaneous nitrification-denitrification in activated sludge systems. ASM2d is based on ASM2 and is expanded to include the denitrifying activity of the phosphorus accumulating organisms (PAOs...

  19. Heterogeneity of Human Research Ethics Committees and Research Governance Offices across Australia: An observational study.

    Science.gov (United States)

    De Smit, Elisabeth; Kearns, Lisa S; Clarke, Linda; Dick, Jonathan; Hill, Catherine L; Hewitt, Alex W

    2016-01-01

    Conducting ethically grounded research is a fundamental facet of all investigations. Nevertheless, the administrative burdens of current ethics review are substantial, and calls have been made for a reduction in research waste. To describe the heterogeneity in administration and documentation required by Human Research Ethics Committees (HRECs) and Research Governance Offices (RGOs) across Australia. In establishing a nationwide study to investigate the molecular aetiology of Giant Cell Arteritis (GCA), for which archived pathological specimens from around Australia are being recruited, we identified variation across separate HREC and RGO requirements. Submission paperwork and correspondence from each collaborating site and its representative office for research were reviewed. This data was interrogated to evaluate differences in current guidelines. Twenty-five pathology departments across seven Australian States collaborated in this study. All states, except Victoria, employed a single ethics review model. There was discrepancy amongst HRECs as to which application process applied to our study: seven requested completion of a "National Ethics Application Form" and three a "Low Negligible Risk" form. Noticeable differences in guidelines included whether electronic submission was sufficient. There was variability in the total number of documents submitted (range five to 22) and panel review turnaround time (range nine to 136 days). We demonstrate the challenges and illustrate the heavy workload involved in receiving widespread ethics and governance approval across Australia. We highlight the need to simplify, homogenise, and nationalise human ethics for non-clinical trial studies. Reducing unnecessary administration will enable investigators to achieve research aims more efficiently.

  20. Co-design and implementation research: challenges and solutions for ethics committees.

    Science.gov (United States)

    Goodyear-Smith, Felicity; Jackson, Claire; Greenhalgh, Trisha

    2015-11-16

    Implementation science research, especially when using participatory and co-design approaches, raises unique challenges for research ethics committees. Such challenges may be poorly addressed by approval and governance mechanisms that were developed for more traditional research approaches such as randomised controlled trials. Implementation science commonly involves the partnership of researchers and stakeholders, attempting to understand and encourage uptake of completed or piloted research. A co-creation approach involves collaboration between researchers and end users from the onset, in question framing, research design and delivery, and influencing strategy, with implementation and broader dissemination strategies part of its design from gestation. A defining feature of co-creation is its emergent and adaptive nature, making detailed pre-specification of interventions and outcome measures impossible. This methodology sits oddly with ethics committee protocols that require precise pre-definition of interventions, mode of delivery, outcome measurements, and the role of study participants. But the strict (and, some would say, inflexible) requirements of ethics committees were developed for a purpose - to protect participants from harm and help ensure the rigour and transparency of studies. We propose some guiding principles to help square this circle. First, ethics committees should acknowledge and celebrate the diversity of research approaches, both formally (through training) and informally (by promoting debate and discussion); without active support, their members may not understand or value participatory designs. Second, ground rules should be established for co-design applications (e.g. how to judge when 'consultation' or 'engagement' becomes research) and communicated to committee members and stakeholders. Third, the benefits of power-sharing should be recognised and credit given to measures likely to support this important goal, especially in research with

  1. [The role of bioethics committees in the systems protecting scientific biomedical research participants in France and in Poland].

    Science.gov (United States)

    Czarkowski, Marek; Sieczych, Alicja

    2013-08-01

    Bioethics committees are along with ethic regulations and rules of law one of three main pillars in the system of protection of scientific biomedical research participants. Although principal directives for bioethics committees are established by international guidelines, detailed regulations may differ in particular states. The aim of this article was to compare two bioethic committees systems: French and Polish one. Historical beginnings of the bioethics committees system in France and in Poland are briefly mentioned, Subsequently, the networks of bioethics committees in both countries are compared. Although the number of bioethics committees (Research Ethic Committees) in both countries is comparable, the procedure of their establishment varies. French committees are based on administrative division of the country and divide on regional and interregional committees. In Poland, bioethics committees are established by medical universities, medical research and development units or regional chambers of physicians and dentists. In France there is no equivalent of Appeal Bioethics Committee, however one could appeal from the negative bioethics committee's opinion. The composition of French bioethics committees is more diverse and half of the members are not related to medical professions. Members of French committees are named on indefinite term by headmaster of Regional Health Agency after having been chosen in competition for the post. In Poland members are called on three-year-term but the rotation of members is not overwhelming since there is no limit of terms for one member. French legal solutions seems more secure for scientific bioethics research participants. For this reason, a detailed research on legislation in other countries is necessary before introducing any new regulations in Polish law.

  2. Evaluation of the work of hospital districts' research ethics committees in Finland.

    Science.gov (United States)

    Halila, Ritva

    2014-12-01

    The main task of research ethics committees (RECs) is to assess research studies before their start. In this study, 24 RECs that evaluate medical research were sent questionnaires about their structure and functions. The RECs were divided into two separate groups: those working in university hospital districts (uRECs) and those in central hospital districts (non-uRECs). The two groups were different in many respects: the uRECs were bigger in size, covered a wider range of disciplines (both medical and non-medical), had better resources and more frequent and regular meetings. After the survey was performed and analysed, the Medical Research Act was amended so that only hospital districts with a medical faculty in their region had a duty to establish ethics committees. After the amendment, the number of RECs evaluating medical research in Finland decreased from 25 to 9. The ethics committees that remained had wider expertise and were better equipped already by the time of this survey. Only one non-uREC was continuing its work, and this was being done under the governance of a university hospital district. Simple measures were used for qualitative analysis of the work of RECs that evaluate medical research. These showed differences between RECs. This may be helpful in establishing an ethics committee network in a research field or administrational area. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  3. Evaluation in health promotion: thoughts from inside a human research ethics committee.

    Science.gov (United States)

    Allen, Judy; Flack, Felicity

    2015-12-01

    Health promotion research, quality improvement and evaluation are all activities that raise ethical issues. In this paper, the Chair and a member of human resear ch ethics committees provide an insiders' point of view on how to demonstrate ethical conduct in health promotion research and quality improvement. Several common issues raised by health promotion research and evaluation are discussed including researcher integrity, conflicts of interest, use of information, consent and privacy.

  4. The 15th Meeting of China-Korea Joint Committee for Basic Scientific Research held in Busan%The 15th Meeting of China-Korea Joint Committee for Basic Scientific Research held in Busan

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The 15th Meeting of the China-Korea Joint Committee for Basic Scientific Research was successfullyheld in Busan, Korea on June 16, 2011. 33 bilateral cooperative projects were selected by the Committee forFY2011, including 21 joint research projects and 12 joint seminars. The Committee members made indepth discussions on the issues of strengthening future cooperation and topics for the Northeastern Asian Symposium.

  5. Multispecies networks: visualizing the psychological research of the Committee for Research in Problems of Sex.

    Science.gov (United States)

    Pettit, Michael; Serykh, Darya; Green, Christopher D

    2015-03-01

    In our current moment, there is considerable interest in networks, in how people and things are connected. This essay outlines one approach that brings together insights from actor-network theory, social network analysis, and digital history to interpret past scientific activity. Multispecies network analysis (MNA) is a means of understanding the historical interactions among scientists, institutions, and preferred experimental animals. A reexamination of studies of sexual behavior funded by the Committee for Research in Problems of Sex between the 1920s and the 1940s demonstrates the applicability of MNA to clarifying the relations that sustained this area of psychology. The measures of weighted degree and betweenness can highlight which nodes (whether organisms or institutions) were particularly "central" to this network. Rats featured as the animals most widely studied during this period, but the analysis also reveals distinct institutional and disciplinary cultures where different species were favored as either surrogates for humans or representatives of more general biological groups.

  6. Consideration of the Construction Code for TBM-body in ASME BPVC

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dongjun; Kim, Yunjae [Korea Univ., Seoul (Korea, Republic of); Kim, Suk Kwon; Park, Sung Dae; Lee, Dong Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    In this paper, ASME code is briefly introduced, and the TBM-body is classified for selecting the ASME section. With the classification of TBM-body, the appropriate section is determined. Helium Cooled Ceramic Reflector (HCCR) Test Blanket System (TBS) has been designed to research on the functions of breeding blanket by KO TBM team. The functions has three subjects as 1) Tritium breeding, 2) Heat conversion and extraction, and 3) Neutron and Gamma-ray shielding. For the process of design, it is needed to select the appropriate construction code as the design criteria. ITER Organization (IO) has proposed that RCC-MR Edition 2007 ver. shall be used for TBM-shield. Because the TBM-shield is connected to the vacuum boundary. For the other part of TBM-set, TBM-body, there is no constraint on the selected code, and the manufacturer can appropriately select the construction code to apply design and fabrication parts. KO TBM Team has considered whether it is appropriate to choose any code for TBM-body. One of the things is ASME code. The advantage of ASME choice is suitable to the domestic status. In the domestic nuclear plant, ASME or KEPIC code is used as regulatory requirements. Based on this, it is possible to prepare a domestic fusion plant regulatory. In this paper, the construction code of TBM-body was determined in ASME BPVC. For the determination of code, the structure of ASME BPVC was introduced and the classification for TBM-body was conducted by the ITER criteria. And the operation conditions of TBM-body that contained creep and irradiation effects was considered to determine the construction code.

  7. Research ethics on the agenda - the debates preceding the establishment of the ethics committees.

    Science.gov (United States)

    Paulsen, Nadia Shad; Lie, Anne Kveim

    2016-11-01

    BACKGROUND This article examines two factors that helped to trigger and drive forward the debate about research ethics committees (now the Regional Committees for Medical and Health Research Ethics) in Norway in the 1970s: the revision of the Declaration of Helsinki by a Scandinavian working group, and the unfolding of the so-called Gro case in the Norwegian national media.METHOD We have used existing literature in the form of books and articles on the history of research ethics from the University Library of the University of Oslo, the National Library of Norway, the History of Science, Technology and Medicine database, and Retriever. We have manually reviewed issues of the Dagbladet daily newspaper from 1974, and relevant volumes of the Journal of the Norwegian Medical Association from the 1960s and 1970s. Finally, we have used the archives of the Norwegian Association of Higher Education Institutions, and the Faculty of Social Sciences at the University of Oslo.RESULTS The World Medical Association's revision of the Declaration of Helsinki in 1975 stipulated the use of independent ethics committees for the assessment and supervision of research projects. The Gro case, which concerned the testing of behavioural therapeutic treatment on a young girl resident in an institution and the ensuing public debate, led to a demand from the public for closer monitoring and ethical regulation of research activity.INTERPRETATION Both of the events mentioned were used actively in the argumentation and preparatory work for the establishment of research ethics committees.

  8. Descriptive ethics: a qualitative study of local research ethics committees in Mexico.

    Science.gov (United States)

    Valdez-Martinez, Edith; Turnbull, Bernardo; Garduño-Espinosa, Juan; Porter, John D H

    2006-05-01

    To describe how local research ethics committees (LRECs) consider and apply research ethics in the evaluation of biomedical research proposals. A qualitative study was conducted using purposeful sampling, focus groups and a grounded theory approach to generate data and to analyse the work of the LRECs. 11 LRECs of the Mexican Institute of Social Security (IMSS). LRECs considered ethics to be implicit in all types of research, but that ethics reviews were only necessary for projects that included the direct participation of human beings. The LRECs appeared to understand the importance of consent, as in the completion of a consent form, but did not emphasise the importance of the process of acquiring 'informed' consent. The committees considered their main roles or functions to be: (a) to improve the methodological quality of research and to verify - if applicable - the ethical aspects; (b) to encourage personnel to undergo research training; (c) to follow-up research to oversee the adherence to norms and compliance with a specified research timetable. This study provides a valuable insight into how these LRECs understand the ethical review process. The emphasis of the committees was on rules, regulations, improving research methodology and research training, rather than a focus on efforts to protect the rights and well being of research subjects. The results encourage further normative and descriptive lines of investigation concerning education and the development of LRECs.

  9. 77 FR 20377 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2012-04-04

    ... of Energy Efficiency and Renewable Energy Biomass Research and Development Technical Advisory... Open Webinar. SUMMARY: This notice announces an open webinar of the Biomass Research and Development..., members of the public are welcome to observe the business of the Biomass Research and...

  10. Dr. Andras Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division, Budapest, Hungary

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 01: Dr András Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division (right) and Barbara Vizkelety Secretary of the Hungarian CERN Committee visiting the ASACUSA experiment on the Antiproton Decelerator Photo 02: Dr András Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division (right) visiting the ASACUSA experiment on the Antiproton Decelerator with (from left to right) Dezso Horvath, Cecilia Jarlskog, Barbara Vizkelety Secretary of the Hungarian CERN Committee. Photo 03: Dr András Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division (right) and Barbara Vizkelety Secretary of the Hungarian CERN Committee visiting the ASACUSA experiment on the Antiproton Decelerator.

  11. Heterogeneity of Human Research Ethics Committees and Research Governance Offices across Australia: An observational study

    Directory of Open Access Journals (Sweden)

    Elisabeth De Smit

    2016-02-01

    Full Text Available Background Conducting ethically grounded research is a fundamental facet of all investigations. Nevertheless, the administrative burdens of current ethics review are substantial, and calls have been made for a reduction in research waste. Aims To describe the heterogeneity in administration and documentation required by Human Research Ethics Committees (HRECs and Research Governance Offices (RGOs across Australia. Methods In establishing a nationwide study to investigate the molecular aetiology of Giant Cell Arteritis (GCA, for which archived pathological specimens from around Australia are being recruited, we identified variation across separate HREC and RGO requirements. Submission paperwork and correspondence from each collaborating site and its representative office for research were reviewed. This data was interrogated to evaluate differences in current guidelines. Results Twenty-five pathology departments across seven Australian States collaborated in this study. All states, except Victoria, employed a single ethics review model. There was discrepancy amongst HRECs as to which application process applied to our study: seven requested completion of a “National Ethics Application Form” and three a “Low Negligible Risk” form. Noticeable differences in guidelines included whether electronic submission was sufficient. There was variability in the total number of documents submitted (range five to 22 and panel review turnaround time (range nine to 136 days. Conclusion We demonstrate the challenges and illustrate the heavy workload involved in receiving widespread ethics and governance approval across Australia. We highlight the need to simplify, homogenise, and nationalise human ethics for non-clinical trial studies. Reducing unnecessary administration will enable investigators to achieve research aims more efficiently

  12. Institutional Animal Care and Use Committee Considerations for the Use of Wildlife in Research and Education.

    Science.gov (United States)

    Sikes, Robert S; Bryan, John A

    2016-01-01

    Ethical and effective oversight of the use of wildlife species in research and education requires consideration of issues and methods not relevant to work with traditional laboratory or domesticated animals, just as the effective oversight of biomedical research requires consideration of issues and methods not germane to wildlife research. Institutional Animal Care and Use Committees or other institutional review committees can meet their responsibilities in these disparate types of animal activities only by using resources tailored to the animals and situations encountered. Here we review the issues and the resources that facilitate effective oversight of such activities in the wildlife research arena available to researchers, institutional review committees, regulatory bodies, and accrediting bodies. Issues covered include an understanding of the fundamental differences between wildlife research and biomedical research; the profound differences between wildlife species and traditional laboratory subjects, most of which are domesticated animals; and the unique issues presented when the research subjects are members of wild populations and communities. We review the resources available for effective oversight of wildlife projects and emphasize that competent oversight of wildlife research demands the use of appropriate resources. These resources include guidelines designed for the use of wild species (taxon-specific guidelines) and protocol forms tailored for the species and situations encountered.

  13. Current Activities of the ASME Subgroup NUPACK

    Energy Technology Data Exchange (ETDEWEB)

    Gerald M. Foster; D. Keith Morton; Paul McConnell

    2007-10-01

    Current activities of the American Society of Mechanical Engineers (ASME), Section III Subgroup on Containment Systems for Spent Fuel High-Level Waste Transport Packagings (also known as Subgroup NUPACK) are reviewed with emphasis on the recent revision of Subsection WB. Also, brief insightson new proposals for the development of rules for internal support structures and for a strain-based acceptance criteria are provided.

  14. 78 FR 37242 - Draft Report and Recommendations Prepared by the Research Committee of the Scientific Working...

    Science.gov (United States)

    2013-06-20

    ... of Justice Programs Draft Report and Recommendations Prepared by the Research Committee of the Scientific Working Group on Medicolegal Death Investigation AGENCY: National Institute of Justice, DOJ..., the U.S. Department of Justice, Office of Justice Programs, National Institute of Justice, Scientific...

  15. 76 FR 9339 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2011-02-17

    ... of Energy Efficiency and Renewable Energy Biomass Research and Development Technical Advisory... Open Meeting. SUMMARY: This notice announces an open meeting of the Biomass Research and Development... on USDA Biomass R&D Activities. Update on DOE Biomass R&D Activities. Overview of the DOE...

  16. 76 FR 63614 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2011-10-13

    ... Doc No: 2011-26476] DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy Biomass Research and.... ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Biomass Research... Update on USDA Biomass R&D Activities; Update on DOE Biomass R&D Activities; Presentation on...

  17. 77 FR 64970 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2012-10-24

    ... Office of Energy Efficiency and Renewable Energy Biomass Research and Development Technical Advisory... open meeting. SUMMARY: This notice announces an open meeting of the Biomass Research and Development... and biobased products. Tentative Agenda: Agenda will include the following: Update on USDA Biomass...

  18. 78 FR 29125 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2013-05-17

    ... of Energy Efficiency and Renewable Energy Biomass Research and Development Technical Advisory... open meeting. SUMMARY: This notice announces an open meeting of the Biomass Research and Development... ] Energy and Agriculture) with respect to the Biomass R&D Initiative (Initiative) and also makes...

  19. 78 FR 8500 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2013-02-06

    ... of Energy Efficiency and Renewable Energy Biomass Research and Development Technical Advisory... Open Meeting. SUMMARY: This notice announces an open meeting of the Biomass Research and Development.... Tentative Agenda: Agenda will include the following: Update on USDA Biomass R&D Activities Update on...

  20. 77 FR 47047 - Biomass Research and Development Technical Advisory Committee

    Science.gov (United States)

    2012-08-07

    ... of Energy Efficiency and Renewable Energy Biomass Research and Development Technical Advisory... open meeting. SUMMARY: This notice announces an open meeting of the Biomass Research ] and Development... Biomass R&D Activities Update on DOE Biomass R&D Activities Review of the recently awarded Biomass...

  1. Reporting ethics committee approval in public administration research.

    Science.gov (United States)

    Jordan, Sara R; Gray, Phillip W

    2014-03-01

    While public administration research is thriving because of increased attention to social scientific rigor, lingering problems of methods and ethics remain. This article investigates the reporting of ethics approval within public administration publications. Beginning with an overview of ethics requirements regarding research with human participants, I turn to an examination of human participants protections for public administration research. Next, I present the findings of my analysis of articles published in the top five public administration journals over the period from 2000 to 2012, noting the incidences of ethics approval reporting as well as funding reporting. In explicating the importance of ethics reporting for public administration research, as it relates to replication, reputation, and vulnerable populations, I conclude with recommendations for increasing ethics approval reporting in public administration research.

  2. Low-frequency electrical dosimetry: research agenda of the IEEE International Committee on Electromagnetic Safety.

    Science.gov (United States)

    Reilly, J Patrick; Hirata, Akimasa

    2016-06-21

    This article treats unsettled issues in the use of numerical models of electrical dosimetry as applied to international limits on human exposure to low-frequency (typically  IEEE-ICES (International Committee on Electromagnetic Safety) Technical Committee 95. The paper discusses 25 issues needing attention, fitting into three general categories: induction models; electrostimulation models; and human exposure limits. Of these, 9 were voted as 'high priority' by members of Subcommittee 6. The list is presented as a research agenda for refinements in numerical modeling with applications to human exposure limits. It is likely that such issues are also important in medical and electrical product safety design applications.

  3. Education in research: results of a survey commissioned by the research committee of the European Society of Radiology

    OpenAIRE

    ,

    2012-01-01

    Objectives The purpose of this investigation was to assess the current status of education in research in Europe with a view to making recommendations and improvements in the status of education in research for involved stakeholders. Methods A questionnaire concerning education in research in Europe was sent to the National Society representatives, to Subspecialty Societies and potentially interested ESR committees. Questions were posed to assess the current status and to explore a desired fu...

  4. 75 FR 38504 - Meetings of the Naval Research Advisory Committee

    Science.gov (United States)

    2010-07-02

    ... current technical core competencies of the Warfare Centers employed by the Systems Commands (SYSCOMs) and Program Executive Offices (PEOs) (as well as the stewardship provided for those competencies and the technical core competencies that are provided by the Navy University Affiliated Research Centers...

  5. 75 FR 37813 - Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2010-06-30

    ..., Office for Human Research Protections (OHRP), or Julia Gorey, J.D., Executive Director, SACHRP; U.S...-8141; fax: 240-453-6909; e-mail address: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the... as sign language interpretation or other reasonable accommodations, should notify the...

  6. Health Research Ethics Committees in South Africa 12 years into democracy

    OpenAIRE

    Myer Landon; Moodley Keymanthri

    2007-01-01

    Abstract Background Despite the growth of biomedical research in South Africa, there are few insights into the operation of Research Ethics Committees (RECs) in this setting. We investigated the composition, operations and training needs of health RECs in South Africa against the backdrop of national and international guidelines. Methods The 12 major health RECs in South Africa were surveyed using semi-structured questionnaires that investigated the composition and functions of each REC as we...

  7. Donating embryos for human embryonic stem cell (hESC) research: a committee opinion.

    Science.gov (United States)

    2013-10-01

    hESC research is an ethically acceptable use of human embryos that are in excess of those needed to meet the fertility goals of patients. The ethical basis for this view and issues to be considered during the informed consent process for the donation of embryos are developed in this document. This report replaces the Committee's 2009 report, "Donating spare embryos for stem cell research" (Fertil Steril 2009;91:667-70).

  8. ASM Based Synthesis of Handwritten Arabic Text Pages.

    Science.gov (United States)

    Dinges, Laslo; Al-Hamadi, Ayoub; Elzobi, Moftah; El-Etriby, Sherif; Ghoneim, Ahmed

    2015-01-01

    Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs) based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available.

  9. ASM Based Synthesis of Handwritten Arabic Text Pages

    Science.gov (United States)

    Al-Hamadi, Ayoub; Elzobi, Moftah; El-etriby, Sherif; Ghoneim, Ahmed

    2015-01-01

    Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs) based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available. PMID:26295059

  10. Incorporating ethical principles into clinical research protocols: a tool for protocol writers and ethics committees.

    Science.gov (United States)

    Li, Rebecca H; Wacholtz, Mary C; Barnes, Mark; Boggs, Liam; Callery-D'Amico, Susan; Davis, Amy; Digilova, Alla; Forster, David; Heffernan, Kate; Luthin, Maeve; Lynch, Holly Fernandez; McNair, Lindsay; Miller, Jennifer E; Murphy, Jacquelyn; Van Campen, Luann; Wilenzick, Mark; Wolf, Delia; Woolston, Cris; Aldinger, Carmen; Bierer, Barbara E

    2016-04-01

    A novel Protocol Ethics Tool Kit ('Ethics Tool Kit') has been developed by a multi-stakeholder group of the Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard. The purpose of the Ethics Tool Kit is to facilitate effective recognition, consideration and deliberation of critical ethical issues in clinical trial protocols. The Ethics Tool Kit may be used by investigators and sponsors to develop a dedicated Ethics Section within a protocol to improve the consistency and transparency between clinical trial protocols and research ethics committee reviews. It may also streamline ethics review and may facilitate and expedite the review process by anticipating the concerns of ethics committee reviewers. Specific attention was given to issues arising in multinational settings. With the use of this Tool Kit, researchers have the opportunity to address critical research ethics issues proactively, potentially speeding the time and easing the process to final protocol approval.

  11. Committee on Interagency Radiation Research and Policy Coordination (CIRRPC)

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-10

    Enclosed are proceedings of the workshop on Internal Dosimetry held on Atlanta, Georgia in April 1992. The recommendations from the Workshop were considered by the CIRRPC Subpanel on Occupational Radiation Protection Research in identifying those areas to be undertaken by individual Federal Agencies or in cooperative efforts. This document presents summaries of the following sessions: A.1 Applications and limitations of ICRP and other metabolic models, A.2 Applications and implementation of proposed ICRP lung model, A.3 Estimates of intake from repetitive bioassay data, A.4 Chelation models for plutonium urinalysis data, B.1 Transuranium/uranium registry data, B.2 Autopsy tissue analysis, B.3 Bioassay / Whole body counting, B.4 Data base formatting and availability, C.1 An overview of calculational techniques in use today, C.2 The perfect code, C.3 Dose calculations based on individuals instead of averages, C.4 From macro dosimetry to micro dosimetry.

  12. The new ASME consensus on operating practices for the control of feedwater and boilerwater chemistry in modern industrial boilers

    Energy Technology Data Exchange (ETDEWEB)

    Tvedt, T.J. Jr. [Dow Chemical Co., Freeport, TX (United States); Holloway, R.T. [Holloway Associates, Islington, Ontario (Canada)

    1997-09-01

    In 1979 the American Society of Mechanical Engineers first published Consensus on Operating Practices for the Control of Feedwater and Boiler Water Quality in Modern Industrial boilers. This document quickly became accepted throughout the world. However, as time went on, it became apparent that the document needed to be revised and expanded. For example, the use of equipment not addressed in the original document (such as waste heat recovery boilers and electrode boilers) became much more common. Furthermore, the original document never addressed issues such as steam purity. In 1994 the ASME Committee on Water and Steam in Thermal Power Systems reissued the Consensus document which included guidance on these and many other important feedwater and boiler water parameters. This paper will briefly contrast the new document with the original one, then discuss the content of the present document. Numerous examples will be used to illustrate the practices recommended by the ASME committee.

  13. Dr. Andras Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division, Budapest, Hungary

    CERN Document Server

    Maximilien Brice

    2002-01-01

    Photo 01: Dr András Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division (right) visiting the ALICE data acquisition laboratory with Ervin Denes. Photo 02: Ervin Denes in the ALICE DAQ (data acquisition) laboratory on the occasion of the visit of Dr András Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division. Photo 03: Detector Data Link and data generator used for data acquisition system of the ALICE experiment photographed on the occasion of the visit of Dr. András Siegler, President of the Hungarian CERN Committee, Ministry of Education, Research and Development Division.

  14. A Retrospective Look at 20 Years of ASM Education Programs (1990-2010 and a Prospective Look at the Next 20 Years (2011-2030

    Directory of Open Access Journals (Sweden)

    Amy Chang

    2011-03-01

    Full Text Available The Education Board of the American Society for Microbiology (ASM was established in the mid-1970s to address the graduate and medical education needs of ASM members. Since then, I have watched our offerings evolve from a small, graduate-level travel grant program for ASM meetings to a growing suite of professional development and networking opportunities including fellowships, publications, and conferences. Along the way, our audience has expanded from  graduate students to undergraduate biology and K-12 teachers, students of all ages, researchers, and the public.I have been fortunate enough to watch several pivotal programs and projects support our growth and change the status quo by providing opportunities for biology educators to flourish. These include the: (i Coalition for Education in the Life Sciences, (ii ASM Division on Microbiology Education, (iii ASM Conference for Undergraduate Educators, (iv ASM Journal of Microbiology & Biology Education, and (v ASM Fellowship Fund. In this review, the background and details I offer on each initiative help explain ASM Education offerings, how our growth has been supported, and where are we headed.

  15. Committee on air pollution effects research: 40 years of UK air pollution.

    Science.gov (United States)

    Fowler, David; Dise, Nancy; Sheppard, Lucy

    2016-01-01

    The UK Committee on Air Pollution Effects Research (CAPER) was established 40 years ago. This special section was compiled to mark this anniversary. During this time there have been dramatic changes in the composition of the air over the UK. The four papers in this special section of Environmental Pollution represent the current air pollution effects research focus on ozone and nitrogen deposition, two related issues and are proving from a policy perspective to be quite intractable issues. The UK CAPER research community continues to advance the underpinning science and engages closely with the user community in government departments.

  16. Are research subjects adequately protected? A review and discussion of studies conducted by the Advisory Committee on Human Radiation Experiments.

    Science.gov (United States)

    Kass, Nancy E; Sugarman, Jeremy

    1996-09-01

    In light of information uncovered about human radiation experiments conducted during the Cold War, an important charge for the Advisory Committee on Human Radiation Experiments was to assess the current state of protections for human research subjects. This assessment was designed to enhance the Committee's ability to make informed recommendations for the improvement of future policies and practices for the protection of research subjects. The Committee's examination of current protections revealed great improvement over those from the past, yet some problems remain. Although the data collected by the Committee highlight specific areas in need of attention, the Committee's work should be viewed in part as the beginning of a series of ongoing assessments of the adequacy and effectiveness of the protections afforded to human subjects.

  17. Proceedings of RIKEN BNL Research Center Workshop, Volume 91, RBRC Scientific Review Committee Meeting

    Energy Technology Data Exchange (ETDEWEB)

    Samios,N.P.

    2008-11-17

    The ninth evaluation of the RIKEN BNL Research Center (RBRC) took place on Nov. 17-18, 2008, at Brookhaven National Laboratory. The members of the Scientific Review Committee (SRC) were Dr. Dr. Wit Busza (Chair), Dr. Miklos Gyulassy, Dr. Akira Masaike, Dr. Richard Milner, Dr. Alfred Mueller, and Dr. Akira Ukawa. We are pleased that Dr. Yasushige Yano, the Director of the Nishina Institute of RIKEN, Japan participated in this meeting both in informing the committee of the activities of the Nishina Institute and the role of RBRC and as an observer of this review. In order to illustrate the breadth and scope of the RBRC program, each member of the Center made a presentation on his/her research efforts. This encompassed three major areas of investigation, theoretical, experimental and computational physics. In addition the committee met privately with the fellows and postdocs to ascertain their opinions and concerns. Although the main purpose of this review is a report to RIKEN Management (Dr. Ryoji Noyori, RIKEN President) on the health, scientific value, management and future prospects of the Center, the RBRC management felt that a compendium of the scientific presentations are of sufficient quality and interest that they warrant a wider distribution. Therefore we have made this compilation and present it to the community for its information and enlightenment.

  18. [About the genesis of the first Polish local research ethics committee].

    Science.gov (United States)

    Paprocka-Lipinska, Anna

    2014-12-01

    From the moment in which the development of medicine became necessary experimental research involving human subjects, the question arose about the ethical limits and limitations of the experiment. The turning point was the year 1947. The Nuremberg Code was formulated after the disclosure of pseudo-medical experiments involving human subjects during the Second World War. In 1964, the medical world accepted the Declaration of Helsinki, which, however, did not prevent abuses and it became necessary to appoint independent ethics committees supervising and enforcing the application of ethics in biomedical experiments. In Poland in the 60's and 70's started a discussion on the ethical rules related to conduct of research involving humans. The initiators of the appointment of bioethics committees were professors of medicine, inspiring experiences of their Western colleagues. It was difficult for reasons of political ideologies to convince the authorities to use the best of western solutions. This paper attempts to describe the circumstances connected with the appointment in 1979 at the Medical University of Gdansk, the first Polish bioethics committee.

  19. Engineering students catch top prizes at ASME competition

    OpenAIRE

    Crumbley, Liz

    2006-01-01

    The Virginia Tech chapter of the American Society of Mechanical Engineers (ASME) carried away several top awards - including one for the design of a fishing apparatus for a quadriplegic - during the recent ASME District F student conference hosted by the University of Tennessee.

  20. Low-frequency electrical dosimetry: research agenda of the IEEE International Committee on Electromagnetic Safety

    Science.gov (United States)

    Reilly, J. Patrick; Hirata, Akimasa

    2016-06-01

    This article treats unsettled issues in the use of numerical models of electrical dosimetry as applied to international limits on human exposure to low-frequency (typically  electromagnetic fields and contact current. The perspective in this publication is that of Subcommittee 6 of IEEE-ICES (International Committee on Electromagnetic Safety) Technical Committee 95. The paper discusses 25 issues needing attention, fitting into three general categories: induction models; electrostimulation models; and human exposure limits. Of these, 9 were voted as ‘high priority’ by members of Subcommittee 6. The list is presented as a research agenda for refinements in numerical modeling with applications to human exposure limits. It is likely that such issues are also important in medical and electrical product safety design applications.

  1. Activities of RILEM Technical Committee: Internal Curing of Concrete and Anticipated Research

    DEFF Research Database (Denmark)

    Kovler, Konstantin; Jensen, Ole Mejlhede

    in the domain. To account for the different practices and different standards around the world, the TC included representatives from three different world regions: Europe, North America and Asia. Totally more than 30 members from 17 countries contributed in the committee work. Some of them serve in parallel...... in ACI, JCI (Japan Concrete Institute) and other well-known research associations in the field of concrete science and engineering. Internal curing, as well as external curing, can be classified into two categories: • Internal water curing (sometimes called “water entrainment”), when the curing agent...... performs as a water reservoir, which gradually releases water, and • Internal sealing, when the curing agent is intended to delay or prevent loss of water from the hardening concrete. The committee addressed both internal water curing and internal sealing, but focused on the first method, which is much...

  2. Report of the second joint Research Committee for Fusion Reactor and Materials. July 12, 2002, Tokyo, Japan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-05-01

    Joint research committees in purpose of the discussion on DEMO blanket in view point of the both of reactor technology and materials were held by the Research Committee for Fusion Reactor and Fusion Materials. The joint research committee was held in Tokyo on July 12, 2002. In the committee, the present status of development of solid and liquid breeding blanket, the present status of development of reduced activation structure materials, and IFMIF (International Fusion Materials Irradiation Facility) program were discussed based on the discussions of the development programs of the blanket and materials at the first joint research committee. As a result, it was confirmed that high electric efficiency with 41% would be obtained in the solid breeding blanket system, that neutron radiation data of reduced activation ferritic steel was obtained by HFIR collaboration, and that KEP (key element technology phase) of IFMIF would be finished at the end of 2002 and the data base for the next step, i.e. EVEDA (engineering validation/engineering design activity) was obtained. In addition, the present status of ITER CTA, which was a transient phase for the construction, and the outline of ITER Fast Track, which was an accelerated plan for the performance of the power plants, were reported. This report consists of the summary of the discussion and the viewgraphs which were used at the second joint research committee, and these are very useful for the researchers of the fusion area in Japan. (author)

  3. Osteoarthritis research priorities: a report from a EULAR ad hoc expert committee.

    Science.gov (United States)

    Conaghan, Philip G; Kloppenburg, Margreet; Schett, Georg; Bijlsma, Johannes W J

    2014-08-01

    Osteoarthritis (OA) currently affects over 40 million Europeans, with its associated personal suffering and significant economic burden for health systems set to dramatically escalate in a rapidly ageing Europe. Given the very limited effective therapeutic options for OA, the European League Against Rheumatism (EULAR) created an ad hoc committee of OA researchers, clinicians and patients to consider a research agenda focussed on the areas of epidemiology, pathogenesis, imaging and biomarkers, and therapies. The committee deliberated and listed research needs in these areas and also established some cross-area priority themes: predictors of OA progression, especially where this might enable stratified interventions; understanding mechanisms of OA pain; improved understanding of tissue communication in a process where multiple tissue pathologies are common; developing concepts of, and consequently interventions for, early OA where both pain and structural processes may be more effectively targeted than in typical clinical presentations; and the need for new treatment strategies, with examples discussed on pathology-targeted therapies and optimal combinations of therapies. This research agenda should provide useful guidance for all researchers in this field and hopefully lead to improved OA care. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  4. The Challenge of Timely, Responsive and Rigorous Ethics Review of Disaster Research: Views of Research Ethics Committee Members

    Science.gov (United States)

    Hunt, Matthew; Tansey, Catherine M.

    2016-01-01

    Background Research conducted following natural disasters such as earthquakes, floods or hurricanes is crucial for improving relief interventions. Such research, however, poses ethical, methodological and logistical challenges for researchers. Oversight of disaster research also poses challenges for research ethics committees (RECs), in part due to the rapid turnaround needed to initiate research after a disaster. Currently, there is limited knowledge available about how RECs respond to and appraise disaster research. To address this knowledge gap, we investigated the experiences of REC members who had reviewed disaster research conducted in low- or middle-income countries. Methods We used interpretive description methodology and conducted in-depth interviews with 15 respondents. Respondents were chairs, members, advisors, or coordinators from 13 RECs, including RECs affiliated with universities, governments, international organizations, a for-profit REC, and an ad hoc committee established during a disaster. Interviews were analyzed inductively using constant comparative techniques. Results Through this process, three elements were identified as characterizing effective and high-quality review: timeliness, responsiveness and rigorousness. To ensure timeliness, many RECs rely on adaptations of review procedures for urgent protocols. Respondents emphasized that responsive review requires awareness of and sensitivity to the particularities of disaster settings and disaster research. Rigorous review was linked with providing careful assessment of ethical considerations related to the research, as well as ensuring independence of the review process. Conclusion Both the frequency of disasters and the conduct of disaster research are on the rise. Ensuring effective and high quality review of disaster research is crucial, yet challenges, including time pressures for urgent protocols, exist for achieving this goal. Adapting standard REC procedures may be necessary. However

  5. The Challenge of Timely, Responsive and Rigorous Ethics Review of Disaster Research: Views of Research Ethics Committee Members.

    Directory of Open Access Journals (Sweden)

    Matthew Hunt

    Full Text Available Research conducted following natural disasters such as earthquakes, floods or hurricanes is crucial for improving relief interventions. Such research, however, poses ethical, methodological and logistical challenges for researchers. Oversight of disaster research also poses challenges for research ethics committees (RECs, in part due to the rapid turnaround needed to initiate research after a disaster. Currently, there is limited knowledge available about how RECs respond to and appraise disaster research. To address this knowledge gap, we investigated the experiences of REC members who had reviewed disaster research conducted in low- or middle-income countries.We used interpretive description methodology and conducted in-depth interviews with 15 respondents. Respondents were chairs, members, advisors, or coordinators from 13 RECs, including RECs affiliated with universities, governments, international organizations, a for-profit REC, and an ad hoc committee established during a disaster. Interviews were analyzed inductively using constant comparative techniques.Through this process, three elements were identified as characterizing effective and high-quality review: timeliness, responsiveness and rigorousness. To ensure timeliness, many RECs rely on adaptations of review procedures for urgent protocols. Respondents emphasized that responsive review requires awareness of and sensitivity to the particularities of disaster settings and disaster research. Rigorous review was linked with providing careful assessment of ethical considerations related to the research, as well as ensuring independence of the review process.Both the frequency of disasters and the conduct of disaster research are on the rise. Ensuring effective and high quality review of disaster research is crucial, yet challenges, including time pressures for urgent protocols, exist for achieving this goal. Adapting standard REC procedures may be necessary. However, steps should be

  6. Extension of ASME VIII Division 1 design limits

    Energy Technology Data Exchange (ETDEWEB)

    Marriott, D.L. [Stress Engineering Services, Inc., Cincinnati, OH (United States). Consumer Products Division

    1995-12-01

    ASME Subcommittee 2 on materials presented a series of questions to PVRC regarding the acceptability of using the criteria of ASME Section 2, Part D, Appendix 1 for extending design limits for AISI 304 stainless steel beyond 1,500 F to 2,000 F and Alloy 800 HT from 1,650 F to 1,800 F respectively. This paper describes a project supported by PVRC to try and find an answer to this question. The project consisted of three parts. The first was a survey to determine the intent behind the wording of the ASME criteria in order to make an extrapolation of methods for setting design limits to higher temperatures. The second was a demonstration of a methodology for developing very high temperature limits, using a set of creep data for Alloy 800 HT. The third was a parametric study to evaluate the feasibility of using the minimum creep rate based deformation criterion used in the ASME Code to set strain related limits on materials showing predominantly tertiary creep. Based on this study, an alternative method to that currently employed by ASME in Appendix 1 has been proposed for setting high temperature design limits, based on a consistent margin on time to failure. This method has been presented to ASME for possible adoption. In addition, this investigation revealed some more detailed issues involving cyclic loading at very high temperature. It was recommended that these should be examined further by ASME. These issues are summarized briefly in this paper.

  7. Accelerator System Model (ASM) user manual with physics and engineering model documentation. ASM version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-07-01

    The Accelerator System Model (ASM) is a computer program developed to model proton radiofrequency accelerators and to carry out system level trade studies. The ASM FORTRAN subroutines are incorporated into an intuitive graphical user interface which provides for the {open_quotes}construction{close_quotes} of the accelerator in a window on the computer screen. The interface is based on the Shell for Particle Accelerator Related Codes (SPARC) software technology written for the Macintosh operating system in the C programming language. This User Manual describes the operation and use of the ASM application within the SPARC interface. The Appendix provides a detailed description of the physics and engineering models used in ASM. ASM Version 1.0 is joint project of G. H. Gillespie Associates, Inc. and the Accelerator Technology (AT) Division of the Los Alamos National Laboratory. Neither the ASM Version 1.0 software nor this ASM Documentation may be reproduced without the expressed written consent of both the Los Alamos National Laboratory and G. H. Gillespie Associates, Inc.

  8. Evaluation of Research Ethics Committees: Criteria for the Ethical Quality of the Review Process.

    Science.gov (United States)

    Scherzinger, Gregor; Bobbert, Monika

    2017-01-01

    Repeatedly, adequacy, performance and quality of Ethics Committees that oversee medical research trials are being discussed. Although they play a crucial role in reviewing medical research and protecting human subjects, it is far from clear to what degree they fulfill the task they have been assigned to. This eventuates in the call for an evaluation of their activity and, in some places, led to the establishment of accreditation schemes. At the same time, IRBs have become subject of detailed legislation in the process of the ongoing global juridification of medical research. Unsurprisingly, there is a tendency to understand the evaluation of RECs as a question of controlling their legal compliance. This paper discusses the need for a quality evaluation of IRBs from an ethical point of view and, by systematically reviewing the major ethical guidelines for IRBs, proposes a system of criteria that should orientate any evaluation of IRBs.

  9. Ethics that exclude: the role of ethics committees in lesbian and gay health research in South Africa.

    Science.gov (United States)

    de Gruchy, J; Lewin, S

    2001-06-01

    Prevailing state and institutional ideologies regarding race/ethnicity, gender, and sexuality help to shape, and are influenced by, research priorities. Research ethics committees perform a gatekeeper role in this process. In this commentary, we describe efforts to obtain approval from the ethics committee of a large medical institution for research into the treatment of homosexual persons by health professionals in the South African military during the apartheid era. The committee questioned the "scientific validity" of the study, viewing it as having a "political" rather than a "scientific" purpose. They objected to the framing of the research topic within a human rights discourse and appeared to be concerned that the research might lead to action against health professionals who committed human rights abuses against lesbians and gay men during apartheid. The process illustrates the ways in which heterosexism, and concerns to protect the practice of health professionals from scrutiny, may influence the decisions of ethics committees. Ethics that exclude research on lesbian and gay health cannot be in the public interest. Ethics committees must be challenged to examine the ways in which institutionalized ideologies influence their decision making.

  10. [The relevance of the International Committee of Medical Journal Editors (ICMJE) for medical publishing and research].

    Science.gov (United States)

    Reyes, Humberto B

    2014-01-01

    The International Committee of Medical Journal Editors is a leading independent institution providing guidance for the report of biomedical research and health related topics in medical journals. Established in 1978, it is currently constituted by editors of fourteen general medical journals from different countries, plus one representative for the US National Library of Medicine and one representative for the World Association of Biomedical Journal Editors. Since 1978 the Committee provides a document, originally named "Uniform Requirements…", "to help authors, editors, and others involved in peer review and biomedical publishing create and distribute accurate, clear, unbiased medical journal articles". This document has been updated several times and the last version was released in August 2013, now renamed "Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals", available in www.icmje.org and citable as "ICMJE Recommendations". A vast proportion of medical journals, worldwide, have adopted these recommendations as rules. The ICMJE discusses and provides guidance on several relevant aspects including criteria on authorship, peer review, scientific misconduct, conflicts of interest, clinical trials registration, good editorial practices, the relations between editors and journal owners, the protection of individuals subject to medical research, the solvency of electronic publications, among others. The 2013 ICMJE Annual Meeting took place in Santiago, Chile, in November 4 and 5. The photograph shows attendants to the final session.

  11. 77 FR 31041 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-American Society...

    Science.gov (United States)

    2012-05-24

    ... of 1993, 15 U.S.C. 4301 et seq. (``the Act''), the American Society of Mechanical Engineers (``ASME... actual damages under specified circumstances. Specifically, since December 1, 2011, ASME has published... charter of three consensus committees within the general nature and scope of ASME's standards...

  12. Sword, Shield and Buoys: A History of the NATO Sub-Committee on Oceanographic Research, 1959–19731

    Science.gov (United States)

    Turchetti, Simone

    2012-01-01

    In the late 1950s the North-Atlantic Treaty Organization (NATO) made a major effort to fund collaborative research between its member states. One of the first initiatives following the establishment of the alliance's Science Committee was the creation of a sub-group devoted to marine science: the Sub-committee on Oceanographic Research.This paper explores the history of this organization, charts its trajectory over the 13 years of its existence, and considers its activities in light of NATO's naval defence strategies. In particular it shows how the alliance's naval commands played a key role in the sub-committee's creation due to the importance of oceanographic research in the tracking of enemy submarines. The essay also scrutinizes the reasons behind the committee's dissolution, with a special focus on the changing landscape of scientific collaboration at NATO. The committee's fall maps onto a more profound shift in the alliance's research agenda, including the re-organization of defence research and the rise of environmentalism. PMID:23935209

  13. Sword, Shield and Buoys: A History of the NATO Sub-Committee on Oceanographic Research, 1959-1973.

    Science.gov (United States)

    Turchetti, Simone

    2012-08-01

    In the late 1950s the North-Atlantic Treaty Organization (NATO) made a major effort to fund collaborative research between its member states. One of the first initiatives following the establishment of the alliance's Science Committee was the creation of a sub-group devoted to marine science: the Sub-committee on Oceanographic Research.This paper explores the history of this organization, charts its trajectory over the 13 years of its existence, and considers its activities in light of NATO's naval defence strategies. In particular it shows how the alliance's naval commands played a key role in the sub-committee's creation due to the importance of oceanographic research in the tracking of enemy submarines. The essay also scrutinizes the reasons behind the committee's dissolution, with a special focus on the changing landscape of scientific collaboration at NATO. The committee's fall maps onto a more profound shift in the alliance's research agenda, including the re-organization of defence research and the rise of environmentalism.

  14. Auriculoterapia en pacientes asmáticos

    Directory of Open Access Journals (Sweden)

    Adolfo González Salvador

    1997-04-01

    Full Text Available Se realiza un estudio para evaluar la eficacia de la auriculopuntura en 30 asmáticos del área de salud de Aguada de Pasajeros, durante los meses de noviembre de 1992 a abril de 1993. El tratamiento se aplicó durante un mes, con seguimiento durante los 5 meses posteriores. Se observó una disminución en la frecuencia, intensidad y duración de las crisis de asma; la mayoría de los pacientes tuvo una evolución satisfactoria y no se presentaron complicaciones. Se concluye que la auriculoterapia es un método útil en pacientes con asma bronquial debido a su eficacia e inocuidadA study was conducted to evaluate the efficacy of auriculopuncture in 30 asthmatic patients from the health area of Aguada de Pasajeros between November, 1992, and April, 1993. The treatment was applied for a month, with a follow-up during the next 5 months. It was observed a reduction in the frequency, intensity and duration of the asthma crises. Most of the patients had a satisfactory evolution and there were no complications. It is concluded that auriculotherapy is a useful method for patients with bronchial asthma due to its effectiveness and innocuousness.

  15. Report of the evaluation by the Ad Hoc Review Committee on Advance Science Research. Result evaluation, interim evaluation, in-advance evaluation in fiscal year 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The Research Evaluation Committee, which consisted of 13 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Advanced Science Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the accomplishments of the research completed in Fiscal Year 2001, the accomplishments of the research started in Fiscal Year 2000, and the adequacy of the programs of the research to be started in Fiscal Year 2003 at Advanced Science Research Center of JAERI. The Ad Hoc Review Committee consisted of eight specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from May to July 2002. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on June 4, 2002, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on August 5, 2002. This report describes the result of the evaluation by the Ad Hoc Review Committee on Advanced Science Research. (author)

  16. PHYSICAL METHODS IN CHEMISTRY INVESTIGATIONS OF THE CHEMISTRY INSTITUTE OF ASM

    Directory of Open Access Journals (Sweden)

    Constantin Turta

    2009-06-01

    Full Text Available The following classes of compounds are presented: terpenes, cyclic nitrogen compounds, dioximates, carboxylates etc., which have been studied with the participation of experts on physical methods of research - IR, UV-Vis, Atomic, Mössbauer spectroscopy, as well as Mass-spectrometry and Nuclear Magnetic Resonance in the IC ASM. Also, a number of significant scientific results obtained in collaboration of chemists and specialists in physical methods are described.

  17. Activities of RILEM Technical Committee: Internal Curing of Concrete and Anticipated Research

    DEFF Research Database (Denmark)

    Kovler, Konstantin; Jensen, Ole Mejlhede

    Novel methods of shrinkage mitigation, based on special advanced methods of internal curing (IC), are currently being intensively studied in research groups in several countries. They have been the focus of the State-of-the-Art report prepared by the Technical Committee TC 196-ICC “Internal Curing...... of Concrete” of the International Union of Laboratories and Experts in Construction Materials, Systems and Structures (RILEM). The authors of this short communication served as a chair (K. Kovler) and secretary (O.M. Jensen) of the TC. The regular and corresponding members were acknowledged RILEM experts...... in ACI, JCI (Japan Concrete Institute) and other well-known research associations in the field of concrete science and engineering. Internal curing, as well as external curing, can be classified into two categories: • Internal water curing (sometimes called “water entrainment”), when the curing agent...

  18. Health Research Ethics Committees in South Africa 12 years into democracy

    Directory of Open Access Journals (Sweden)

    Myer Landon

    2007-01-01

    Full Text Available Abstract Background Despite the growth of biomedical research in South Africa, there are few insights into the operation of Research Ethics Committees (RECs in this setting. We investigated the composition, operations and training needs of health RECs in South Africa against the backdrop of national and international guidelines. Methods The 12 major health RECs in South Africa were surveyed using semi-structured questionnaires that investigated the composition and functions of each REC as well as the operational issues facing committees. Results Health RECs in SA have an average of 16 members and REC members are predominantly male and white. Overall, there was a large discrepancy in findings between under-resourced RECs and well resourced RECs. The majority of members (56% are scientists or clinicians who are typically affiliated to the same institution as the health REC. Community representatives account for only 8% of membership. Training needs for health REC members varied widely. Conclusion Most major health RECs in South Africa are well organized given the resource constraints that exist in relation to research ethics in developing countries. However, the gender, racial and occupational diversity of most of these RECs is suboptimal, and most RECs are not constituted in accordance with South African guidelines. Variability in the operations and training needs of RECs is a reflection of apartheid-entrenched influences in tertiary education in SA. While legislation now exists to enforce standardization of research ethics review systems, no provision has been made for resources or capacity development, especially to support historically-disadvantaged institutions. Perpetuation of this legacy of apartheid represents a violation of the principles of justice and equity.

  19. [Experience of a research Ethics Committee and the challenges of the new Chilean legislation on research in human beings].

    Science.gov (United States)

    Oyarzún G, Manuel; Pinto C, María Eugenia; Raineri B, Gina G; Amigo, Hugo; Cifuentes O, Lucía; González, María Julieta; Horwitz, Nina; Marshall F, Claudia; Orellana V, Gricel

    2014-07-01

    The welfare of research participants must be guaranteed by international ethical standards. This article communicates the procedures of the Research Ethics Committee of the School of Medicine, University of Chile (CEISH). The new Chilean legislation on research in human beings is also discussed. Law 20.120: "On scientific research in human beings, its genome and forbidding human cloning" establishes the ethical principles that must be accomplished in every research involving human beings. Article 28 of the Law 20.584 "Regulation of the rights and duties of health care users", forbids the participation of handicapped people who cannot express their will in scientific research. Article 13 states that people not related directly with patient care cannot have access to his clinical records (with the exception of people with notarial authorization by the patient). CEISH proposes that, in case of people with intellectual deficiency, the decision to approve a scientific research should be analyzed on an individual basis. If the person is capable of expressing his or her will or has stated his or her consent beforehand, the research can be authorized. If the person cannot express his or her will, the scientific research cannot take place. In prospective studies, a consent from the patient and an authorization of the health authority should be required to access clinical records. In retrospective studies, consent should be obtained from the patient when personal information is going to be used. If the information is nameless, the consent can be disregarded.

  20. The Ethics of Traditional Chinese and Western Herbal Medicine Research: Views of Researchers and Human Ethics Committees in Australia

    Directory of Open Access Journals (Sweden)

    Caroline A. Smith

    2011-01-01

    Full Text Available Despite the growth of traditional Chinese medicine (TCM and western herbal medicine (WHM research in Australia, little is known about how ethics committees (HRECs assess the ethics of TCM or WHM research. The objectives of this study were to examine the experiences of TCM and WHM researchers and HRECs with the evaluation of ethics applications. Two cross-sectional surveys were undertaken of HRECs and TCM and WHM researchers in Australia. Anonymous self-completion questionnaires were administered to 224 HRECs and 117 researchers. A response confirming involvement in TCM or WHM research applications was received from 20 HRECs and 42 researchers. The most frequent ethical issues identified by HRECs related to herbal products including information gaps relating to mode of action of herbal medicines and safety when combining herbal ingredients. Researchers concurred that they were frequently requested to provide additional information on multiple aspects including safety relating to the side effects of herbs and herb-drug interactions. Overall adherence with the principles of ethical conduct was high among TCM and WHM researchers although our study did identify the need for additional information regarding assessment of risk and risk management.

  1. Networking 2.0: Expanding your collaboration circles through the Interagency Arctic Research Policy Committee (IARPC)

    Science.gov (United States)

    Rohde, J. A.; Bowden, S.; Stephenson, S. N.; Starkweather, S.

    2015-12-01

    The Interagency Arctic Research Policy Committee (IARPC) envisions a prosperous, sustainable, and healthy Arctic understood through innovative and collaborative research coordinated among Federal agencies and domestic and international partners. IARPC's approach is to harnesses the talent of the scientific and stakeholder community through Federally-run but broadly open collaboration teams, and an innovative website that expands the frontiers of collaborative research. The Obama Administration released the five-year Arctic Research Plan: FY2013-2017 in February 2013. The Plan focuses on advancing knowledge and sustainability of the Arctic by improving collaboration in seven priority research areas: sea ice and marine ecosystems, terrestrial ice and ecosystems, atmospheric studies, observing systems, regional climate models, human health studies, and adaptation tools for communities. From these seven research areas, 12 collaboration teams were formed to respond to the 145 milestones laid out in the Plan. The collaboration teams are charged with enhancing inter-institutional and interdisciplinary implementation of scientific research on local, regional, and circumpolar environmental and societal issues in the Arctic. The collaboration teams are co-chaired by Federal program managers, and, in some cases, external partners and are open to research and stakeholder communities. They meet on a regular basis by web- or teleconference to inform one another about ongoing and planned programs and new research results, as well as to inventory existing programs, identify gaps in knowledge and research, and address and implement the Plan's milestones. In-between meetings, team members communicate via our innovative, user-driven, collaboration website. Members share information about their research activities by posting updates, uploading documents, and including events on our calendar, and entering into dialogue about their research activities. Conversations taking place on the

  2. The SCAR Standing Committee on Antarctic Data Management - new directions in access to Antarctic research data

    Science.gov (United States)

    de Bruin, T.

    2009-04-01

    The SCAR Standing Committee on Antarctic Data Management (SC-ADM) was established by the Scientific Committee on Antarctic Research (SCAR) and the Council of Managers of National Antarctic Programs (COMNAP), to assist in the fulfillment of the data management obligations imposed by the Antarctic Treaty (section III.1.c): "Scientific observations and results from Antarctica shall be exchanged and made freely available." SC-ADM comprises representatives of the National Antarctic Data Centres or national points of contact. Currently 31 nations around the world are represented in SC-ADM. So far, SC-ADM has been focussing on the coordination of the Antarctic Master Directory (AMD), the internationally accessible, web-based, searchable record of Antarctic and Southern Ocean data set descriptions. The AMD is directly integrated into the international Global Change Master Directory (GCMD) to help further merge Antarctic science into global science. The AMD is a resource for scientists to advertise the data they have collected and to search for data they may need. Currently, SC-ADM is in a transition phase, moving forward to provide data access. Existing systems and web services technology will be used as much as possible, to increase efficiency and prevent 're-inventing the wheel' This poster will give an overview of this process, the current status and the expected results.

  3. Overall Assessment of Human Research and Ethics Committees in the United Arab Emirates.

    Science.gov (United States)

    Abdulrahman, Mahera; Nair, Satish Chandrasekhar

    2017-04-01

    Growing demand for human health research in the United Arab Emirates (UAE) has prompted the need to develop a robust research ethics oversight. Examination of the structure, function, and practices of the human research ethics committees (HRECs), followed by evaluation of standards for measuring research output, was conducted. Results indicate that among the HRECs, 90% followed International Council for Harmonization-Good Clinical Practice guidelines, 66.6% have been in operation for more than 5 years, 95% reviewed proposals within 8 weeks, and 56% reviewed for scientific merit apart from ethics. However, systems to recognize accomplishments of researchers, funding transparency, and adverse event reporting were deployed in less than 30% of all HRECs. Research was incorporated into the vision and mission statements of many (65%) organizations. Research publications, collaborations, and recognitions were used to measure research output and report key performance indicators. In spite, resources to generate research output such as dedicated budget (20%), support staff (20%), and continuous training and mentoring program for medical residents (15%) and HREC members (25%) were somehow lacking. HREC structure and operations in the UAE are similar to other regions of the world. Systems to conduct research and report outcomes are defined in the UAE. Regulatory legislation and allocation of resources to support the clinical research enterprise will not only help to meet growing demand for clinical trials but also transform the quality of patient care in the UAE. It is anticipated that the results of this study will benefit investigators, regulators, pharmaceutical sponsors, and the policy makers in the region.

  4. Report of the evaluation by the Ad Hoc Review Committee on Materials Science Research. In-advance evaluation in fiscal year 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The Research Evaluation Committee, which consisted of 13 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Materials Science Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the adequacy of the R and D programs to be implemented for five years starting in Fiscal Year 2003 at Department of Materials Science in Tokai Research Establishment of JAERI. The Ad Hoc Review Committee consisted of eight specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from April 2002 to August 2002. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on June 5th, 2002, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on August 5th, 2002. This report describes the result of the evaluation by the Ad Hoc Review Committee on Materials Science Research. (author)

  5. Report of the evaluation by the Ad Hoc Review Committee on Materials Science Research. In-advance evaluation in fiscal year 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The Research Evaluation Committee, which consisted of 13 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Materials Science Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the adequacy of the R and D programs to be implemented for five years starting in Fiscal Year 2003 at Department of Materials Science in Tokai Research Establishment of JAERI. The Ad Hoc Review Committee consisted of eight specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from April 2002 to August 2002. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on June 5th, 2002, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on August 5th, 2002. This report describes the result of the evaluation by the Ad Hoc Review Committee on Materials Science Research. (author)

  6. Unintended consequences of human research ethics committees: au revoir workplace studies?

    Science.gov (United States)

    Bamber, Greg J; Sappey, Jennifer

    2007-07-01

    To protect the welfare and rights of participants in research and to facilitate research that will be of benefit, as well as protect them against litigation, universities and research-funding agencies in Australia adopted the National Statement on Ethical Conduct in Research Involving Humans (NHMRC 1999). In many other countries there are similar statements. However, the ways in which such statements are often implemented by Human Research Ethics Committees (HRECs) are in conflict with an important stream of industrial sociological research. This stream seeks to deconstruct workplaces and de-layer management rhetoric to understand the realities and complexities of the social relations of production. There is a pluralist basis for much industrial sociology that challenges the unitarist view of the workplace as essentially harmonious. While views of workplaces as being conflictual and exploitative have to be tempered with an understanding of the accommodative and cooperative nature of workplace relations, there is nevertheless a general recognition of acts of resistance, as well as those of cooperation. The way in which the National Statement is typically implemented in Australia means that many HRECs require written, informed consent, which in the first instance will usually be that of management. An unintended consequence is a research focus on consensus, which is at best one-sided and at worst seriously misleading. It is unlikely that managerial consent will be granted unless there is a 'good news story' guaranteed. This article explores the ways in which HRECs may influence workplace research. The publication of the revised National Statement provides a valuable opportunity not to be missed by HRECs to implement more effective and efficient practices which would not have the unintended consequences of the earlier version. This would deserve the support of researchers in industrial sociology and other branches of the social sciences.

  7. Animal models in epigenetic research: institutional animal care and use committee considerations across the lifespan.

    Science.gov (United States)

    Harris, Craig

    2012-01-01

    The rapid expansion and evolution of epigenetics as a core scientific discipline have raised new questions about how endogenous and environmental factors can inform the mechanisms through which biological form and function are regulated. Existing and proposed animal models used for epigenetic research have targeted a myriad of health and disease endpoints that may be acute, chronic, and transgenerational in nature. Initiating events and outcomes may extend across the entire lifespan to elicit unanticipated phenotypes that are of particular concern to institutional animal care and use committees (IACUCs). The dynamics and plasticity of epigenetic mechanisms produce effects and consequences that are manifest differentially within discreet spatial and temporal contexts, including prenatal development, stem cells, assisted reproductive technologies, production of sexual dimorphisms, senescence, and others. Many dietary and nutritional interventions have also been shown to have a significant impact on biological functions and disease susceptibilities through altered epigenetic programming. The environmental, chemical, toxic, therapeutic, and psychosocial stressors used in animal studies to elicit epigenetic changes can become extreme and should raise IACUC concerns for the well-being and proper care of all research animals involved. Epigenetics research is rapidly becoming an integral part of the search for mechanisms in every major area of biomedical and behavioral research and will foster the continued development of new animal models. From the IACUC perspective, care must be taken to acknowledge the particular needs and concerns created by superimposition of epigenetic mechanisms over diverse fields of investigation to ensure the proper care and use of animals without impeding scientific progress.

  8. [Independent ethics committees for clinical research in Argentina. An evaluation and a system to guarantee their independence].

    Science.gov (United States)

    Gonorazky, Sergio E

    2008-01-01

    The Administración Nacional de Medicamentos, Alimentos y Tecnología Médica de la República Argentina (ANMAT) requires that an independent ethics committee of sponsors and/or researchers must previously evaluate and approve all the new pharmacological research protocols carried out on human beings. However, due to the lucrative nature of the evaluation, and because the selection of the Independent Ethics Committee is carried out by the sponsors and/or researchers, the assumed autonomy of the former can be reduced to merely a relationship of "service provider-customer". The Institutional Review Board of the Mar del Plata s Community Hospital has evaluated, between 2005 and 2006, thirty three research protocols (with their corresponding information sheets for patients and informed consent forms) previously approved by a non-institutional Independent Ethics Committee. The median number of objections made by the Institutional Review Board, which prompted the previously mentioned protocols to be modified in order to be approved, was of three per protocol. In other words, the accreditation of an Independent Ethics Committee requires a system that guarantees actual independence from the sponsors and/or researchers, as well as management control mechanisms that may lead them into an eventual loss of accreditation. Several measures are proposed in order to correct the deficiencies of the present system.

  9. Protected Lists of Members : Experiment Committees, Research Board and LHC-RRBs

    CERN Document Server

    Mage-Granados, Patricia

    2016-01-01

    Defines the use of the Sharepoint Site : http://cern.ch/scientific-committees/, where all members of any CERN Scientific Committee are listed. Different views shhow 'active' or 'all' (history). The end date of a mandate automatically removes an entry from the 'active' view but keeps it under 'all'. Some entries are double, e.g. if a member becomes ex-officio or changes from one committee to another.

  10. News from the Library: A new key reference work for the engineer: ASME's Boiler and Pressure Vessel Code at the CERN Library

    CERN Multimedia

    CERN Library

    2011-01-01

    The Library is aiming at offering a range of constantly updated reference books, to cover all areas of CERN activity. A recent addition to our collections strengthens our offer in the Engineering field.   The CERN Library now holds a copy of the complete ASME Boiler and Pressure Vessel Code, 2010 edition. This code establishes rules of safety governing the design, fabrication, and inspection of boilers and pressure vessels, and nuclear power plant components during construction. This document is considered worldwide as a reference for mechanical design and is therefore important for the CERN community. The Code published by ASME (American Society of Mechanical Engineers) is kept current by the Boiler and Pressure Committee, a volunteer group of more than 950 engineers worldwide. The Committee meets regularly to consider requests for interpretations, revision, and to develop new rules. The CERN Library receives updates and includes them in the volumes until the next edition, which is expected to ...

  11. Penetration of ASM 981 in canine skin: a comparative study.

    Science.gov (United States)

    Gutzwiller, Meret E Ricklin; Reist, Martin; Persohn, Elke; Peel, John E; Roosje, Petra J

    2006-01-01

    ASM 981 has been developed for topical treatment of inflammatory skin diseases. It specifically inhibits the production and release of pro-inflammatory cytokines. We measured the skin penetration of ASM 981 in canine skin and compared penetration in living and frozen skin. To make penetration of ASM 981 visible in dog skin, tritium labelled ASM 981 was applied to a living dog and to defrosted skin of the same dog. Using qualitative autoradiography the radioactive molecules were detected in the lumen of the hair follicles until the infundibulum, around the superficial parts of the hair follicles and into a depth of the dermis of 200 to 500 microm. Activity could not be found in deeper parts of the hair follicles, the dermis or in the sebaceous glands. Penetration of ASM 981 is low in canine skin and is only equally spread in the upper third of the dermis 24 hours after application. Penetration in frozen skin takes even longer than in living canine skin but shows the same distribution.

  12. The policies of ethics committees in the management of biobanks used for research: an Italian survey.

    Science.gov (United States)

    Porteri, Corinna; Togni, Elena; Pasqualetti, Patrizio

    2014-02-01

    Gaps in regulations pertaining to the collection and storage of biological materials in a biobank, at least in the European context, have made the writing of local guidelines essential from an ethical point of view. Nevertheless, until recently, the elaboration of local guidelines for the collection, use and storage of biological materials in a biobank has been the exception in Italy and all European countries. In this context, it is of value to know the policies, even if they are unwritten, of local ethics committees (ECs) engaged in the evaluation of research protocols involving biobanks and biological materials. This paper presents the results of a survey carried out among local Italian ECs (229) to document their attitudes and policies regarding the management of the ethical issues related to biobanks and the use of biological materials. A questionnaire was developed to investigate the areas regarded as critical from an ethical-legal point of view: informed consent and information to the subjects; protection of confidentiality; communication of research results; access/transfer of biological materials and related data; ownership of samples and data and intellectual property rights; and subjects' remuneration and benefit sharing. Twenty-six ECs from the Italian Institutes for Research and Care (62%) and 26 other ECs (14%) participated in the survey.

  13. The National Shipbuilding Research Program, Proceedings of the REAPS Technical Symposium Paper No. 1: Ship Production Committee Panel Overviews

    Science.gov (United States)

    1980-10-01

    consensus specification, we experienced sematical problems. Avondale Shipyards, Inc. requested Mr. Richard Muther , President of Richard Muther and...1978, Mr. Richard Muther addressed the panel. His primary objective was definition which would do away with the sematical problems. Mr. Richard Muther’s...COMMITTEE PANEL OVERVIEWS SP-1 - SHIPYARD FACILITIES AND ENVIRONMENTAL EFFECTS Richard A. Price Program Manager Maritime Administration Research and

  14. New Semantic Model for Authentication Protocols in ASMs

    Institute of Scientific and Technical Information of China (English)

    Rui Xue; Deng-Guo Feng

    2004-01-01

    A new semantic model in Abstract State Model(ASM)for authentication protocols is presented.It highlights the Woo-Lam's ideas for authentication,which is the strongest one in Lowe's definition hierarchy for entity authentication.Apart from the flexible and natural features in forming and analyzing protocols inherited from ASM,the model defines both authentication and secrecy properties explicitly in first order sentences as invariants.The process of proving security properties with respect to an authentication protocol blends the correctness and secrecy properties together to avoid the potential flaws which may happen when treated separately.The security of revised Helsinki protocol is shown as a case study.The new model is different from the previous ones in ASMs.

  15. 75 FR 41439 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2010-07-16

    ... distribution of public presentation materials to the Committee members, the Committee suggests that presenters forward the public presentation materials prior to the meeting to Ms. Springer via e-mail. The Assistant... conference, submit inquiries to Ms. Yvette Springer at Yspringer@bis.doc.gov no later than July 27, 2010....

  16. 75 FR 72792 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2010-11-26

    ... come, first serve basis. To join the conference, submit inquiries to Ms. Yvette Springer at Yspringer... the meeting. However, to facilitate the distribution of public presentation materials to the Committee members, the Committee suggests that presenters forward the public presentation materials prior to...

  17. 75 FR 62508 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2010-10-12

    ... a first come, first serve basis. To join the conference, submit inquiries to Ms. Yvette Springer at... after the meeting. However, to facilitate the distribution of public presentation materials to the Committee members, the Committee suggests that presenters forward the public presentation materials prior...

  18. New directions and challenges for the O&M committee

    Energy Technology Data Exchange (ETDEWEB)

    Pelletier, J.P.

    1996-12-01

    In the second half of the decade of the nineties, the imperative of finding new ways to improve efficiency while maintaining safety is taking on a new urgency. The looming deregulation of the electric industry and the expected competition in the power production business fuels this urgency. The recently completed ASME research in the area of Risk-Based Inservice Testing offers the Operations and Maintenance (O&M) Committee an opportunity to meet this challenge. This opportunity, however, offers its own challenges. New ways of thinking about inservice testing and new technical skills will be needed to successfully incorporate this technology into Code documents. It will not be adequate to rely solely on incorporation of risk-based methods into the Code to meet this challenge. A thorough self assessment of what O&M does, how it is done, and the value added will help assure that the directions which are pursued do, indeed, meet the challenge ahead.

  19. AsmL Specification of a Ptolemy II Scheduler

    DEFF Research Database (Denmark)

    Lázaro Cuadrado, Daniel; Koch, Peter; Ravn, Anders Peter

    2003-01-01

    Ptolemy II is a tool that combines different computational models for simulation and design of embedded systems. AsmL is a software specification language based on the Abstract State Machine formalism. This paper reports on development of an AsmL model of the Synchronous Dataflow domain scheduler...... of Ptolemy II. By building this model we can give precise semantics to the implementation. Furthermore it allows us to isolate the scheduling problem from the tool and make the potential parallelism of the implementation explicit. The model is executable and is tested against the implementation...

  20. 76 FR 29756 - Office of Planning, Research and Evaluation; Advisory Committee on Head Start Research and...

    Science.gov (United States)

    2011-05-23

    ... interpretations of the findings, discussing implications for practice and policy, and providing recommendations on... implementation of best practices in Head Start and other early childhood programs around the country. DATES: The... early childhood programs by enhancing the use of research-informed practices in early childhood. Finally...

  1. 14 CFR 330.31 - What data must air carriers submit concerning ASMs or RTMs?

    Science.gov (United States)

    2010-01-01

    ... combination passenger/cargo carrier, you must have submitted your August 2001 total completed ASM report to... correct an error that you document to the Department, you must not alter the ASM or RTM reports...

  2. Research ethics committees in the regulation of clinical research: comparison of Finland to England, Canada, and the United States.

    Science.gov (United States)

    Hemminki, Elina

    2016-01-19

    The aim of this paper is to compare common features and variation in the work of research ethics committees (RECs) in Finland to three other countries - England, Canada, the United States of America (USA) - in the late 2000s. Several approaches and data sources were used, including semi- or unstructured interviews of experts, documents, previous reports, presentations in meetings and observations. A theoretical framework was created and data from various sources synthesized. In Finland, RECs were regulated by a medical research law, whereas in the other countries many related laws and rules guided RECs; drug trials had specific additional rules. In England and the USA, there was a REC control body. In all countries, members were voluntary and included lay-persons, and payment arrangements varied. Patient protection was the main ethics criteria, but other criteria (research advancement, availability of results, payments, detailed fulfilment of legislation) varied. In all countries, RECs had been given administrative duties. Variations by country included the mandate, practical arrangements, handling of multi-site research, explicitness of proportionate handlings, judging scientific quality, time-limits for decisions, following of projects, role in institute protection, handling conflicts of interests, handling of projects without informed consent, and quality assurance research. The division of work between REC members and secretariats varied in checking of formalities. In England, quality assurance of REC work was thorough, fairly thorough in the USA, and not performed in Finland. The work of RECs in the four countries varied notably. Various deficiencies in the system require action, for which international comparison can provide useful insights.

  3. Impact of the economic crisis on the activity of a clinical research ethics committee

    Directory of Open Access Journals (Sweden)

    Paula Arcenillas

    2014-11-01

    Full Text Available Purpose: Analyze the impact of economic and social crisis in volume and funding of clinical trials (CT and observational studies (ES from the activity of an Research Ethics Committee (REC. Method: REC memories 2003-2012 were reviewed. Financing of evaluated projects, CT and OS were analyzed classifying them into four groups: 1 promoted by pharmaceutical industry, 2 by scientific societies with industry support, 3 by scientific societies with government support and 4 unfunding.Two periods were compared: pre-crisis (2003-2007 and crisis (2008-2012. Results: During 10 studied years, 744 protocols were evaluated: a 71% of group 1, a 9% of group 2, a 3% of group 3 and a 17% was no funding. Regarding OS, 40%, 5,4%, 8,6% and 46% were the groups 1, 2, 3 and 4 respectively. Analyzing crisis versus pre-crisis period, statistically significant differences were observed in the decreasing of number of CT phase 2 and 3 and in the rising EO. Comparing crisis related to the pre-crisis period, the Group 4 increased statistically significantly. Conclusions: Evolution of total number of studies evaluated by REC tends to be maintained and even increased over time. REC maintains its activity and even increased at the expense of financing and unfunded OS.

  4. [Impact of the economic crisis on the activity of a clinical research ethics committee].

    Science.gov (United States)

    Redondo Capafons, S; Arcenillas, Paula; Giménez, Nuria; March López, Pablo; Soriano, Laura; Pla, Ramon; Quintana, Salvador

    2014-11-03

    Analyze the impact of economic and social crisis in volume and funding of clinical trials (CT) and observational studies (ES) from the activity of an Research Ethics Committee (REC). REC memories 2003-2012 were reviewed. Financing of evaluated projects, CT and OS were analyzed classifying them into four groups: 1) promoted by pharmaceutical industry, 2) by scientific societies with industry support, 3) by scientific societies with government support and 4) unfunding.Two periods were compared: pre-crisis (2003-2007) and crisis (2008-2012). During 10 studied years, 744 protocols were evaluated: a 71% of group 1, a 9% of group 2, a 3% of group 3 and a 17% was no funding. Regarding OS, 40%, 5,4%, 8,6% and 46% were the groups 1, 2, 3 and 4 respectively. Analyzing crisis versus pre-crisis period, statistically significant differences were observed in the decreasing of number of CT phase 2 and 3 and in the rising EO. Comparing crisis related to the pre-crisis period, the Group 4 increased statistically significantly. Evolution of total number of studies evaluated by REC tends to be maintained and even increased over time. REC maintains its activity and even increased at the expense of financing and unfunded OS. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  5. After-School Math PLUS (ASM+) Final Evaluation Report

    Science.gov (United States)

    Academy for Educational Development, 2007

    2007-01-01

    This report summarizes findings from the Academy for Educational Development's (AED's) evaluation of After-School Math PLUS (ASM+). This program was designed to help students find the math in everyday experiences and create awareness about the importance of math skills for future career options. The evaluation was conducted by AED's Center for…

  6. 46 CFR 57.02-2 - Adoption of section IX of the ASME Code.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of section IX of the ASME Code. 57.02-2 Section... AND BRAZING General Requirements § 57.02-2 Adoption of section IX of the ASME Code. (a) The... accordance with section IX of the ASME (American Society of Mechanical Engineers) Code, as limited,...

  7. The How of Successful Citizen Advisory Committee Operation. A Research and Development Project: Citizen Participation in Policy Making for Public Schools in Illinois.

    Science.gov (United States)

    Phipps, Lloyd J.; Knell, Kenneth

    As a means of encouraging the formation of school-sponsored, citizen advisory committees, the Illinois Citizens Education Council embarked on a 3-year research and development project. This publication describes this project and thereby serves as a guide for organizing and using citizens' education advisory committees. Specific objectives of the…

  8. Recommendations for research studies on treatment of idiopathic scoliosis: Consensus 2014 between SOSORT and SRS non-operative management committee.

    Science.gov (United States)

    Negrini, Stefano; Hresko, Timothy M; O'Brien, Joseph P; Price, Nigel

    2015-01-01

    The two main societies clinically dealing with idiopathic scoliosis are the Scoliosis Research Society (SRS), founded in 1966, and the international Society on Scoliosis Orthopedic and Rehabilitation Treatment (SOSORT), started in 2004. Inside the SRS, the Non-Operative Management Committee (SRS-NOC) has the same clinical interest of SOSORT, that is the Orthopaedic and Rehabilitation (or Non-Operative, or conservative) Management of idiopathic scoliosis patients. The aim of this paper is to present the results of a Consensus among the best experts of non-operative treatment of Idiopathic Scoliosis, as represented by SOSORT and SRS, on the recommendation for research studies on treatment of Idiopathic Scoliosis. The goal of the consensus statement is to establish a framework for research with clearly delineated inclusion criteria, methodologies, and outcome measures so that future meta- analysis or comparative studies could occur. A Delphi method was used to generate a consensus to develop a set of recommendations for clinical studies on treatment of Idiopathic Scoliosis. It included the development of a reference scheme, which was judged during two Delphi Rounds; after this first phase, it was decided to develop the recommendations and 4 other Delphi Rounds followed. The process finished with a Consensus Meeting, that was held during the SOSORT Meeting in Wiesbaden, 8-10 May 2014, moderated by the Presidents of SOSORT (JP O'Brien) and SRS (SD Glassman) and by the Chairs of the involved Committees (SOSORT Consensus Committee: S Negrini; SRS Non-Operative Committee: MT Hresko). The Boards of the SRS and SOSORT formally accepted the final recommendations. The 18 Recommendations focused: Research needs (3), Clinically significant outcomes (4), Radiographic outcomes (3), Other key outcomes (Quality of Life, adherence to treatment) (2), Standardization of methods of non-operative research (6).

  9. Governance and oversight of researcher access to electronic health data: the role of the Independent Scientific Advisory Committee for MHRA database research, 2006-2015.

    Science.gov (United States)

    Waller, P; Cassell, J A; Saunders, M H; Stevens, R

    2017-03-01

    In order to promote understanding of UK governance and assurance relating to electronic health records research, we present and discuss the role of the Independent Scientific Advisory Committee (ISAC) for MHRA database research in evaluating protocols proposing the use of the Clinical Practice Research Datalink. We describe the development of the Committee's activities between 2006 and 2015, alongside growth in data linkage and wider national electronic health records programmes, including the application and assessment processes, and our approach to undertaking this work. Our model can provide independence, challenge and support to data providers such as the Clinical Practice Research Datalink database which has been used for well over 1,000 medical research projects. ISAC's role in scientific oversight ensures feasible and scientifically acceptable plans are in place, while having both lay and professional membership addresses governance issues in order to protect the integrity of the database and ensure that public confidence is maintained.

  10. Identifying structures, processes, resources and needs of research ethics committees in Egypt

    Directory of Open Access Journals (Sweden)

    Sleem Hany

    2010-06-01

    Full Text Available Abstract Background Concerns have been expressed regarding the adequacy of ethics review systems in developing countries. Limited data are available regarding the structural and functional status of Research Ethics Committees (RECs in the Middle East. The purpose of this study was to survey the existing RECs in Egypt to better understand their functioning status, perceived resource needs, and challenges. Methods We distributed a self-administered survey tool to Egyptian RECs to collect information on the following domains: general characteristics of the REC, membership composition, ethics training, workload, process of ethics review, perceived challenges to effective functioning, and financial and material resources. We used basic descriptive statistics to evaluate the quantitative data. Results We obtained responses from 67% (12/18 of the identified RECs. Most RECs (10/12 have standard operating procedures and many (7/12 have established policies to manage conflicts of interests. The average membership was 10.3 with a range from 7-19. The predominant member type was physicians (69.5% of all of the REC members with little lay representation (13.7%. Most RECs met at least once/month and the average number of protocols reviewed per meeting was 3.8 with a range from 1-10. Almost three-quarters of the members from all of the 12 RECs indicated they received some formal training in ethics. Regarding resources, roughly half of the RECs have dedicated capital equipment (e.g., meeting room, computers, office furniture, etc; none of the RECs have a formal operating budget. Perceived challenges included the absence of national research ethics guidelines and national standards for RECs and lack of ongoing training of its members in research ethics. Conclusion Our study documents several areas of strengths and areas for improvements in the operations of Egyptian RECs. Regarding strengths, many of the existing RECs meet frequently, have a majority of members

  11. Reasons for resubmission of research projects to the research ethics committee of a University Hospital in São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Mariana Bueno

    2009-01-01

    Full Text Available INTRODUCTION: It is important to know the reasons for resubmitting research projects to the Research Ethics Committee in order to help researchers to prepare their research projects, informed consent forms and needed research documentation. OBJECTIVES: To verify the reasons for resubmitting projects that were previously rejected by the Ethics Committee. METHOD: This is a cross-sectional study that evaluated research projects involving human beings. Research projects were submitted in 2007 to the Research Ethics Committee of the Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo. RESULTS: One thousand two hundred and fifty six research projects were submitted to the ethics committee and the average time for evaluating the research projects and related documents until a final decision was reached was 49.95 days. From the total, 399 projects were reviewed in 2 or more meetings until a final decision was reached. Of these, 392 research projects were included in the study; 35 projects were subsequently excluded for involving animals. Among the research projects included, 42.5% concerned research with new drugs, vaccines and diagnostic tests, 48.5% consisted of undergraduate students' research projects, 68.9% of the research had no sponsorship, and 97.5% were eventually approved. The main reasons for returning the projects to the researchers were the use of inadequate language and/or difficulty of understanding the informed consent form (32.2%, lack of information about the protocol at the informed consent form (25.8%, as well as doubts regarding methodological and statistical issues of the protocol (77.1%. Other reasons for returning the research projects involved lack of, inaccuracy on or incomplete documentation, need of clarification or approval for participation of external entities on the research, lack of information on financial support. CONCLUSION: Among the research projects that were returned to the researchers for

  12. About the Dissertations in Geological Sciences defended at Dissertation Committee Д 212.189.01 of the Perm State National Research University in 2013

    Directory of Open Access Journals (Sweden)

    V. A. Gershanok

    2014-03-01

    Full Text Available The article contains the information about the candidate’s dissertations in geological sciences defended at the Dissertation Committee of Perm State National Research University in 2013. The annotations of these works are presented as well.

  13. Assessment of ASME code examinations on regenerative, letdown and residual heat removal heat exchangers

    Energy Technology Data Exchange (ETDEWEB)

    Gosselin, Stephen R.; Cumblidge, Stephen E.; Anderson, Michael T.; Simonen, Fredric A.; Tinsley, G. A.; Lydell, B.; Doctor, Steven R.

    2005-07-01

    Inservice inspection requirements for pressure retaining welds in the regenerative, letdown, and residual heat removal heat exchangers are prescribed in Section XI Articles IWB and IWC of the ASME Boiler and Pressure Vessel Code. Accordingly, volumetric and/or surface examinations are performed on heat exchanger shell, head, nozzle-to-head, and nozzle-to-shell welds. Inspection difficulties associated with the implementation of these Code-required examinations have forced operating nuclear power plants to seek relief from the U.S. Nuclear Regulatory Commission. The nature of these relief requests are generally concerned with metallurgical, geometry, accessibility, and radiation burden. Over 60% of licensee requests to the NRC identify significant radiation exposure burden as the principle reason for relief from the ASME Code examinations on regenerative heat exchangers. For the residual heat removal heat exchangers, 90% of the relief requests are associated with geometry and accessibility concerns. Pacific Northwest National Laboratory was funded by the NRC Office of Nuclear Regulatory Research to review current practice with regard to volumetric and/or surface examinations of shell welds of letdown heat exchangers regenerative heat exchangers and residual (decay) heat removal heat exchangers Design, operating, common preventative maintenance practices, and potential degradation mechanisms are reviewed. A detailed survey of domestic and international PWR-specific operating experience was performed to identify pressure boundary failures (or lack of failures) in each heat exchanger type and NSSS design. The service data survey was based on the PIPExp® database and covers PWR plants worldwide for the period 1970-2004. Finally a risk assessment of the current ASME Code inspection requirements for residual heat removal, letdown, and regenerative heat exchangers is performed. The results are then reviewed to discuss the examinations relative to plant safety and

  14. The ASM-NSF Biology Scholars Program: An Evidence-Based Model for Faculty Development.

    Science.gov (United States)

    Chang, Amy L; Pribbenow, Christine M

    2016-05-01

    The American Society for Microbiology (ASM) established its ASM-NSF (National Science Foundation) Biology Scholars Program (BSP) to promote undergraduate education reform by 1) supporting biologists to implement evidence-based teaching practices, 2) engaging life science professional societies to facilitate biologists' leadership in scholarly teaching within the discipline, and 3) participating in a teaching community that fosters disciplinary-level science, technology, engineering, and mathematics (STEM) reform. Since 2005, the program has utilized year-long residency training to provide a continuum of learning and practice centered on principles from the scholarship of teaching and learning (SoTL) to more than 270 participants ("scholars") from biology and multiple other disciplines. Additionally, the program has recruited 11 life science professional societies to support faculty development in SoTL and discipline-based education research (DBER). To identify the BSP's long-term outcomes and impacts, ASM engaged an external evaluator to conduct a study of the program's 2010-2014 scholars (n = 127) and society partners. The study methods included online surveys, focus groups, participant observation, and analysis of various documents. Study participants indicate that the program achieved its proposed goals relative to scholarship, professional society impact, leadership, community, and faculty professional development. Although participants also identified barriers that hindered elements of their BSP participation, findings suggest that the program was essential to their development as faculty and provides evidence of the BSP as a model for other societies seeking to advance undergraduate science education reform. The BSP is the longest-standing faculty development program sponsored by a collective group of life science societies. This collaboration promotes success across a fragmented system of more than 80 societies representing the life sciences and helps

  15. Regulatory Safety Issues in the Structural Design Criteria of ASME Section III Subsection NH and for Very High Temperatures for VHTR & GEN IV

    Energy Technology Data Exchange (ETDEWEB)

    William J. O’Donnell; Donald S. Griffin

    2007-05-07

    The objective of this task is to identify issues relevant to ASME Section III, Subsection NH [1], and related Code Cases that must be resolved for licensing purposes for VHTGRs (Very High Temperature Gas Reactor concepts such as those of PBMR, Areva, and GA); and to identify the material models, design criteria, and analysis methods that need to be added to the ASME Code to cover the unresolved safety issues. Subsection NH was originally developed to provide structural design criteria and limits for elevated-temperature design of Liquid Metal Fast Breeder Reactor (LMFBR) systems and some gas-cooled systems. The U.S. Nuclear Regulatory Commission (NRC) and its Advisory Committee for Reactor Safeguards (ACRS) reviewed the design limits and procedures in the process of reviewing the Clinch River Breeder Reactor (CRBR) for a construction permit in the late 1970s and early 1980s, and identified issues that needed resolution. In the years since then, the NRC and various contractors have evaluated the applicability of the ASME Code and Code Cases to high-temperature reactor designs such as the VHTGRs, and identified issues that need to be resolved to provide a regulatory basis for licensing. This Report describes: (1) NRC and ACRS safety concerns raised during the licensing process of CRBR , (2) how some of these issues are addressed by the current Subsection NH of the ASME Code; and (3) the material models, design criteria, and analysis methods that need to be added to the ASME Code and Code Cases to cover unresolved regulatory issues for very high temperature service.

  16. 76 FR 72902 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2011-11-28

    ..., submit inquiries to Ms. Yvette Springer at ] Yvette.Springer@bis.doc.gov no later than, December 7, 2011... that presenters forward the public presentation materials prior to the meeting to Ms. Springer via... information, call Yvette Springer at (202) 482-2813. Dated: November 21, 2011. Yvette Springer, Committee...

  17. 76 FR 10004 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2011-02-23

    ... the conference, submit inquiries to Ms. Yvette Springer at Yspringer@bis.doc.gov no later than, March... that presenters forward the public presentation materials prior to the meeting to Ms. Springer via... information, call Yvette Springer at (202) 482-2813. Dated: February 17, 2011. Yvette Springer, Committee...

  18. 77 FR 39209 - Emerging Technology and Research Advisory Committee; Notice of Open Meeting

    Science.gov (United States)

    2012-07-02

    ..., submit inquiries to Ms. Yvette Springer at Yvette.Springer@bis.doc.gov , no later than July 12, 2012. A... forward the public presentation materials prior to the meeting to Ms. Springer via email. For more information, call Yvette Springer at (202) 482-2813. Dated: June 27, 2012. Teresa Telesco, Assistant Committee...

  19. 75 FR 18484 - Emerging Technology and Research Advisory Committee; Notice of Open Meeting

    Science.gov (United States)

    2010-04-12

    ..., submit inquiries to Ms. Yvette Springer at Yspringer@bis.doc.gov no later than April 19, 2010. A limited... forward the public presentation materials prior to the meeting to Ms. Springer via email. For more information, call Yvette Springer at (202) 482-2813. Dated: April 6, 2010. Yvette Springer, Committee Liaison...

  20. 76 FR 54734 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2011-09-02

    ... Ms. Yvette Springer at Yvette.Springer@bis.doc.gov no later than September 9, 2011. A limited number... the public presentation materials prior to the meeting to Ms. Springer via e-mail. The Assistant... Springer at (202) 482-2813. Dated: August 29, 2011. Yvette Springer, Committee Liaison Officer. BILLING...

  1. 78 FR 21346 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2013-04-10

    ... Ms. Yvette Springer at Yvette.Springer@bis.doc.gov no later than, April 18, 2013. A limited number of... presentation materials prior to the meeting to Ms. Springer via email. For more information, call Yvette Springer at (202) 482-2813. ] Dated: April 4, 2013. Yvette Springer, Committee Liaison Officer. BILLING...

  2. 77 FR 19179 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2012-03-30

    ..., submit inquiries to Ms. Yvette Springer at Yvette.Springer@bis.doc.gov no later than April 9, 2012. A... forward the public presentation materials prior to the meeting to Ms. Springer via email. For more information, call Yvette Springer at (202) 482-2813. Dated: March 26, 2012. Yvette Springer, Committee Liaison...

  3. 77 FR 70140 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting

    Science.gov (United States)

    2012-11-23

    ... join the conference, submit inquiries to Ms. Yvette Springer at Yvette.Springer@bis.doc.gov no later.... Springer via email. The Assistant Secretary for Administration, with the concurrence of the delegate of the..., call Yvette Springer at (202) 482-2813. Dated: November 19, 2012. Yvette Springer, Committee...

  4. ASME code ductile failure criteria for impulsively loaded pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Nickell, Robert E.; Duffey, T. A. (Thomas A.); Rodriguez, E. A. (Edward A.)

    2003-01-01

    Ductile failure criteria suitable for application to impulsively loaded high pressure vessels that are designed to the rules of the ASME Code Section VI11 Division 3 are described and justified. The criteria are based upon prevention of load instability and the associated global failure mechanisms, and on protection against progressive distortion for multiple-use vessels. The criteria are demonstrated by the design and analysis of vessels that contain high explosive charges.

  5. 专家谈ASME BPE——推动ASME BPE在亚洲的应用

    Institute of Scientific and Technical Information of China (English)

    Tony Cirillo

    2007-01-01

    ASME BPE是一种国际行业规范,其应用的领域包括生物产品的生产,制药业和个人护理品业等,目前已在世界30多个国家进行认证工作。但作为经济飞速发展的亚洲国家一直鲜有参与。因此,ASME BPE委员会非常希望招募亚洲国家成员.并使其参与到规范的制订中,以扩大规范的使用领域。

  6. HIV/AIDS research conducted in the developing world and sponsored by the developed world: reporting of research ethics committee review in two countries.

    Science.gov (United States)

    Chin, Lisa Judy; Rifai-Bashjawish, Hoda; Kleinert, Kelly; Saltman, Alexandra; Leu, Cheng-Shiun; Klitzman, Robert

    2011-09-01

    We explored how often journal articles reporting HIV research sponsored by a developed country, but conducted in a developing country, mention research ethics committee (REC) approval from both countries, and what factors are involved. Of all such 2007 articles on Medline conducted in one of four developing countries (N = 154), only 52% mentioned such dual approval. Mention of dual vs. single approval was more likely among articles with ≥ 50% sponsor country authors, and the United States as the sponsor country. Also, dual approval was more likely among articles that mentioned informed consent and funding, had ≥ 50% sponsor country authors, were biomedical (vs. psychosocial), and appeared in journals adopting International Committee Medical Journal Editors (ICMJE) guidelines. Dual approval was thus obtained in only half of the articles and was associated with ethical and logistic issues, indicating the need for clearer and more universally accepted guidelines.

  7. Using the activated sludge model 2d (ASM2d) to understand and predict the phosphorus accumulating organisms mechanism in enhanced biological phosphorus removal in relation to disintegrated sludge as a carbon source

    OpenAIRE

    Boontian, Nittaya

    2012-01-01

    Carbon sources are considered as one of the most important factors in the performance of enhanced biological phosphorus removal (EBPR). Disintegrated sludge (DS) can act as carbon source to increase the efficiency of EBPR. This research explores the influence of DS upon phosphorus removal efficiency using mathematical simulation modeling. Activated Sludge Model No. 2d (ASM2d) is one of the most useful of activated sludge (AS) models. This is because ASM2d can express the integrated mechanisms...

  8. ASM News Volume 71 Number 9, 2005

    Energy Technology Data Exchange (ETDEWEB)

    Tamar Barkay and Barth F. Smets

    2005-01-01

    Genetic exchanges among prokaryotes, formerly considered only a marginal phenomenon, increasingly are being viewed as profoundly affecting evolution. Indeed, some researchers argue for utterly revamping our concept of microbial speciation and phylogeny by replacing the traditional ''tree'' with a newer ''net'' to account for these horizontal transfers of genes. This conceptual ferment is occurring while molecular biologists reveal how horizontal gene transfers occur even as microbes protect the integrity of their genomes. Other studies reveal the number and diversity and abundance of genetic elements that mediate horizontal gene transfers (HGTs) or facilitate genome rearrangements, deletions, and insertions. Taken together, this information suggests that microbial communities collectively possess a dynamic gene pool, where novel genetic combinations act as a driving force in genomic innovation, compensating individual microbial species for their inability to reproduce sexually. These microbial genomic dynamics can present both environmental threats and promise to humans. One major threat, for example, comes from the spread of antibiotic resistance and virulence genes among pathogenic microbes. Another less-documented issue involves transgenic plants and animals, whose uses are being restricted because of concerns that genes may be transferred to untargeted organisms where they might cause harm. A possible benefit from HGT comes from its potential to enhance the functional diversity of microbial communities and to improve their performance in changing or extreme environments. Such changes might be exploited, for example, as part of efforts to manage environmental pollution and might be achieved by spreading genes into resident microbes to confer specific biochemical activities.

  9. Gender equality in the work of local research ethics committees in Europe: a study of practice in five countries.

    Science.gov (United States)

    Moerman, C J; Haafkens, J A; Söderström, M; Rásky, E; Maguire, P; Maschewsky-Schneider, U; Norstedt, M; Hahn, D; Reinerth, H; McKevitt, N

    2007-02-01

    Funding organisations and research ethics committees (RECs) should play a part in strengthening attention to gender equality in clinical research. In the research policy of European Union (EU), funding measures have been taken to realise this, but such measures are lacking in the EU policy regarding RECs. To explore how RECs in Austria, Germany, Ireland, The Netherlands and Sweden deal with gender equality issues by asking two questions: (1) Do existing procedures promote representation of women and gender expertise in the committee? (2) How are sex and gender issues dealt with in protocol evaluation? Two RECs were selected from each country. Data were obtained through interviews with key informants and content analysis of relevant documents (regulations, guidelines and review tools in use in 2003). All countries have rules (mostly informal) to ensure the presence of women on RECs; gender expertise is not required. Drug study protocols are carefully evaluated, sometimes on a formal basis, as regards the inclusion of women of childbearing age. The reason for excluding either one of the sexes or including specific groups of women or making a gender-specific risk-benefit analysis are investigated by some RECs. Such measures are, however, neither defined in the regulations nor integrated in review tools. The RECs investigated in five European member states are found to pay limited attention to gender equality in their working methods and, in particular in protocol evaluation. Policy and regulations of EU are needed to strengthen attention to gender equality in the work of RECs.

  10. ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas.

    Science.gov (United States)

    Israël-Assayag, Evelyne; Beaulieu, Marie-Josée; Cormier, Yvon

    2015-01-01

    Inhaled β2-adrenoreceptor agonists are widely used in asthma and chronic obstructive pulmonary disease (COPD) for bronchoconstriction relief. β2-Adrenoreceptor agonists relax airway smooth muscle cells via cyclic adenosine monophosphate (cAMP) mediated pathways. However, prolonged stimulation induces functional desensitization of the β2-adrenoreceptors (β2-AR), potentially leading to reduced clinical efficacy with chronic or prolonged administration. ASM-024, a small synthetic molecule in clinical stage development, has shown activity at the level of nicotinic receptors and possibly at the muscarinic level and presents anti-inflammatory and bronchodilator properties. Aerosolized ASM-024 reduces airway resistance in mice and promotes in-vitro relaxation of tracheal and bronchial preparations from animal and human tissues. ASM-024 increased in vitro relaxation response to maximally effective concentration of short-acting beta-2 agonists in dog and human bronchi. Although the precise mechanisms by which ASM-024 promotes airway smooth muscle (ASM) relaxation remain unclear, we hypothesized that ASM-024 will attenuate and/or abrogate agonist-induced contraction and remain effective despite β2-AR tachyphylaxis. β2-AR tachyphylaxis was induced with salbutamol, salmeterol and formoterol on guinea pig tracheas. The addition of ASM-024 relaxed concentration-dependently intact or β2-AR desensitized tracheal rings precontracted with methacholine. ASM-024 did not induce any elevation of intracellular cAMP in isolated smooth muscle cells; moreover, blockade of the cAMP pathway with an adenylate cyclase inhibitor had no significant effect on ASM-024-induced guinea pig trachea relaxation. Collectively, these findings show that ASM-024 elicits relaxation of β2-AR desensitized tracheal preparations and suggest that ASM-024 mediates smooth muscle relaxation through a different target and signaling pathway than β2-adrenergic receptor agonists. These findings suggest ASM-024

  11. [Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.

    Science.gov (United States)

    Sweeney, David; Hollins, Fay; Gomez, Edith; Saunders, Ruth; Challiss, R A John; Brightling, Christopher E

    2014-07-01

    The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.

  12. Estado asmático en niños.

    Directory of Open Access Journals (Sweden)

    Camilo Cañas

    2009-10-01

    Full Text Available El estado asmático es una entidad que se ve con relativa frecuencia en los servicios de emergencia; el pilar de su tratamiento son los esteroides y los ß-agonistas. Sin embargo cuando el enfermo no responde favorablemente al tratamiento se debe recurrir a otras alternativas como: adrenalina subcutánea, anticolinérgicos, aminofilina, sulfato de magnesio, helio, gases anestésicos, etc. Sólo 5% de los casos de asma severa requieren ventilación mecánica pero en tales ocasiones la mortalidad puede ser 13%.

  13. Dose reconstruction for the Urals population. Joint Coordinating Committee on Radiation Effects Research, Project 1.1 -- Final report

    Energy Technology Data Exchange (ETDEWEB)

    Degteva, M.O. [Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation); Drozhko, E. [Branch 1 of Moscow Biophysics Inst., Ozersk (Russian Federation); Anspaugh, L.R. [Lawrence Livermore National Lab., CA (United States); Napier, B.A. [Pacific Northwest National Lab., Richland, WA (United States); Bouville, A.C. [National Cancer Inst., Bethesda, MD (United States); Miller, C.W. [Centers for Disease Control and Prevention, Atlanta, GA (United States)

    1996-02-01

    This work is being carried out as a feasibility study to determine if a long-term course of work can be implemented to assess the long-term risks of radiation exposure delivered at low to moderate dose rates to the populations living in the vicinity of the Mayak Industrial Association (MIA). This work was authorized and conducted under the auspices of the US-Russian Joint Coordinating Committee on Radiation Effects Research (JCCRER) and its Executive Committee (EC). The MIA was the first Russian site for the production and separation of plutonium. This plant began operation in 1948, and during its early days there were technological failures that resulted in the release of large amounts of waste into the rather small Techa River. There were also gaseous releases of radioiodines and other radionuclides during the early days of operation. In addition, there was an accidental explosion in a waste storage tank in 1957 that resulted in a significant release. The Techa River Cohort has been studied for several years by scientists from the Urals Research Centre for Radiation Medicine and an increase in both leukemia and solid tumors has been noted.

  14. Animal Care Use Committees.

    Science.gov (United States)

    Snyder, Margaret D.; And Others

    1992-01-01

    Describes the structure, activities, responsibilities, and practices of animal care and use committees established to review classroom activities and student research using animals. Provides six hypothetical situations with suggested solutions to test a committee's decision-making ability. Includes a proposed activity form for teachers. (MDH)

  15. Personality and culture, the Social Science Research Council, and liberal social engineering: the Advisory Committee on Personality and Culture, 1930-1934.

    Science.gov (United States)

    Bryson, Dennis

    2009-01-01

    The field of personality and culture was given a significant impetus during the 1930s with the establishment of the Advisory Committee on Personality and Culture (1930-1934) by the Social Science Research Council. This committee provided an early formulation of personality and culture that emphasized the interdisciplinary focus on the processes of personality formation within small-scale social settings. The committee's formulation also coupled personality and culture with a liberal social engineering approach geared toward cultural reconstruction. Major social scientists and clinicians were involved in the activities of the committee, including Edward Sapir, W. I. Thomas, E. W. Burgess, E. A. Bott, Robert S. Woodworth, Harry Stack Sullivan, C. M. Hincks, and Adolf Meyer.

  16. Energy in transition, 1985-2010. Final report of the Committee on Nuclear and Alternative Energy Systems, National Research Council

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    This exhaustive study, in assessing the roles of nuclear and alternative energy systems in the nation's energy future, focuses on the period between 1985 and 2010. Its intent is to illuminate the kinds of options the nation may wish to keep open in the future and to describe the actions, policies, and R and D programs that may be required to do so. The timing and the context of these decisions depend not only on the technical, social, and economic features of energy-supply technologies, but also on assumptions about future demand for energy and the possibilities for energy conservation through changes in consumption patterns and improved efficiency of the supply and end-use systems. The committee developed a three-tiered functional structure for the project. The first tier was CONAES itself, whose report embodies the ultimate findings, conclusions, and judgments of the study. To provide scientific and engineering data and economic analyses for the committee, a second tier of four panels was appointed by the committee to examine (1) energy demand and conservation, (2) energy supply and delivery systems, (3) risks and impacts of energy supply and use, and (4) various models of possible future energy systems and decision making. Each panel in turn established a number of resource groups - some two dozen in all - to address in detail an array of more particular matters. Briefly stated, recommended strategies are: (1) increased energy conservation; (2) expansion of the nation's balanced coal and nuclear electrical generation base; (3) retention of the breeder option; (4) stimulation of fluid energy development; and (5) immediate increase in research and development of new energy options to ensure availability over the long term.

  17. Discriminating Between Legitimate and Predatory Open Access Journals: Report from the International Federation for Emergency Medicine Research Committee

    Directory of Open Access Journals (Sweden)

    Bhakti Hansoti

    2016-09-01

    Full Text Available Introduction: Open access (OA medical publishing is growing rapidly. While subscription-based publishing does not charge the author, OA does. This opens the door for “predatory” publishers who take authors’ money but provide no substantial peer review or indexing to truly disseminate research findings. Discriminating between predatory and legitimate OA publishers is difficult. Methods: We searched a number of library indexing databases that were available to us through the University of California, Irvine Libraries for journals in the field of emergency medicine (EM. Using criteria from Jeffrey Beall, University of Colorado librarian and an expert on predatory publishing, and the Research Committee of the International Federation for EM, we categorized EM journals as legitimate or likely predatory. Results: We identified 150 journal titles related to EM from all sources, 55 of which met our criteria for OA (37%, the rest subscription based. Of these 55, 25 (45% were likely to be predatory. We present lists of clearly legitimate OA journals, and, conversely, likely predatory ones. We present criteria a researcher can use to discriminate between the two. We present the indexing profiles of legitimate EM OA journals, to inform the researcher about degree of dissemination of research findings by journal. Conclusion: OA journals are proliferating rapidly. About half in EM are legitimate. The rest take substantial money from unsuspecting, usually junior, researchers and provide no value for true dissemination of findings. Researchers should be educated and aware of scam journals.

  18. Shortcomings of protocols of drug trials in relation to sponsorship as identified by Research Ethics Committees: analysis of comments raised during ethical review

    NARCIS (Netherlands)

    Lent, M.J. van; Rongen, G.A.; Out, H.J.

    2014-01-01

    BACKGROUND: Submission of study protocols to research ethics committees (RECs) constitutes one of the earliest stages at which planned trials are documented in detail. Previous studies have investigated the amendments requested from researchers by RECs, but the type of issues raised during REC revie

  19. 75 FR 8789 - Research Advisory Committee on Gulf War Veterans' Illnesses; Notice of Meeting

    Science.gov (United States)

    2010-02-25

    ... Secretary of Veterans Affairs on proposed research studies, research plans and research strategies relating.... Individuals who speak are invited to submit a 1-2 page summary of their comments at the time of the...

  20. 77 FR 31071 - Research Advisory Committee on Gulf War Veterans' Illnesses, Notice of Meeting

    Science.gov (United States)

    2012-05-24

    ... research studies, research plans and research strategies relating to the health consequences of military... speak and will be accommodated on a first-come, first-served basis. Individuals who speak are invited...

  1. PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP, VOLUME 77, RBRC SCIENTIFIC REVIEW COMMITTEE MEETING, OCTOBER 10-12, 2005

    Energy Technology Data Exchange (ETDEWEB)

    SAMIOS, N.P.

    2005-10-10

    The eighth evaluation of the RIKEN BNL Research Center (RBRC) took place on October 10-12, 2005, at Brookhaven National Laboratory. The members of the Scientific Review Committee (SRC) were Dr. Jean-Paul Blaizot, Professor Makoto Kobayashi, Dr. Akira Masaike, Professor Charles Young Prescott (Chair), Professor Stephen Sharpe (absent), and Professor Jack Sandweiss. We are grateful to Professor Akira Ukawa who was appointed to the SRC to cover Professor Sharpe's area of expertise. In addition to reviewing this year's program, the committee, augmented by Professor Kozi Nakai, evaluated the RBRC proposal for a five-year extension of the RIKEN BNL Collaboration MOU beyond 2007. Dr. Koji Kaya, Director of the Discovery Research Institute, RIKEN, Japan, presided over the session on the extension proposal. In order to illustrate the breadth and scope of the RBRC program, each member of the Center made a presentation on higher research efforts. In addition, a special session was held in connection with the RBRC QCDSP and QCDOC supercomputers. Professor Norman H. Christ, a collaborator from Columbia University, gave a presentation on the progress and status of the project, and Professor Frithjof Karsch of BNL presented the first physics results from QCDOC. Although the main purpose of this review is a report to RIKEN Management (Dr. Ryoji Noyori, RIKEN President) on the health, scientific value, management and future prospects of the Center, the RBRC management felt that a compendium of the scientific presentations are of sufficient quality and interest that they warrant a wider distribution. Therefore we have made this compilation and present it to the community for its information and enlightenment.

  2. ASME Code requirements for multi-canister overpack design and fabrication

    Energy Technology Data Exchange (ETDEWEB)

    SMITH, K.E.

    1998-11-03

    The baseline requirements for the design and fabrication of the MCO include the application of the technical requirements of the ASME Code, Section III, Subsection NB for containment and Section III, Subsection NG for criticality control. ASME Code administrative requirements, which have not historically been applied at the Hanford site and which have not been required by the US Nuclear Regulatory Commission (NRC) for licensed spent fuel casks/canisters, were not invoked for the MCO. As a result of recommendations made from an ASME Code consultant in response to DNFSB staff concerns regarding ASME Code application, the SNF Project will be making the following modifications: issue an ASME Code Design Specification and Design Report, certified by a Registered Professional Engineer; Require the MCO fabricator to hold ASME Section III or Section VIII, Division 2 accreditation; and Use ASME Authorized Inspectors for MCO fabrication. Incorporation of these modifications will ensure that the MCO is designed and fabricated in accordance with the ASME Code. Code Stamping has not been a requirement at the Hanford site, nor for NRC licensed spent fuel casks/canisters, but will be considered if determined to be economically justified.

  3. Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma.

    Science.gov (United States)

    Teoh, Chun Ming; Tam, John Kit Chung; Tran, Thai

    2012-01-01

    Airway hyperresponsiveness (AHR) is one of the cardinal features of asthma. Contraction of airway smooth muscle (ASM) cells that line the airway wall is thought to influence aspects of AHR, resulting in excessive narrowing or occlusion of the airway. ASM contraction is primarily controlled by agonists that bind G protein-coupled receptor (GPCR), which are expressed on ASM. Integrins also play a role in regulating ASM contraction signaling. As therapies for asthma are based on symptom relief, better understanding of the crosstalk between GPCRs and integrins holds good promise for the design of more effective therapies that target the underlying cellular and molecular mechanism that governs AHR. In this paper, we will review current knowledge about integrins and GPCRs in their regulation of ASM contraction signaling and discuss the emerging concept of crosstalk between the two and the implication of this crosstalk on the development of agents that target AHR.

  4. A Review & Assessment of Current Operating Conditions Allowable Stresses in ASME Section III Subsection NH

    Energy Technology Data Exchange (ETDEWEB)

    R. W. Swindeman

    2009-12-14

    The current operating condition allowable stresses provided in ASME Section III, Subsection NH were reviewed for consistency with the criteria used to establish the stress allowables and with the allowable stresses provided in ASME Section II, Part D. It was found that the S{sub o} values in ASME III-NH were consistent with the S values in ASME IID for the five materials of interest. However, it was found that 0.80 S{sub r} was less than S{sub o} for some temperatures for four of the materials. Only values for alloy 800H appeared to be consistent with the criteria on which S{sub o} values are established. With the intent of undertaking a more detailed evaluation of issues related to the allowable stresses in ASME III-NH, the availabilities of databases for the five materials were reviewed and augmented databases were assembled.

  5. A legacy of the ""megagoule committee,"" thirty years of explosive pulsed power research and development at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Goforth, James H [Los Alamos National Laboratory; Oona, Henn [Los Alamos National Laboratory; Herrera, Dennis H [Los Alamos National Laboratory; Torres, David T [Los Alamos National Laboratory; Tasker, D. G. [Los Alamos National Laboratory; Meyer, R. K. [Los Alamos National Laboratory; Atchison, W. L. [Los Alamos National Laboratory; Rousculp, C. L. [Los Alamos National Laboratory; Reinovsky, R. E. [Los Alamos National Laboratory; Sheppard, M. [Los Alamos National Laboratory; Turchi, P. J. [Los Alamos National Laboratory; Watt, R. G. [Los Alamos National Laboratory

    2010-10-29

    In 1980, Los Alamos formed the 'Megajoule Committee' with the expressed goal of developing a one Megajoule plasma radiation source. The ensuing research and development has given rise to a wide variety of high explosive pulsed power accomplishments, and there is a continuous stream of work that continues to the present. A variety of flux compression generators (FCGs or generators) have been designed and tested, and a number of pulse shortening schemes have been investigated. Supporting computational tools have been developed in parallel with experiments. No fewer that six unique systems have been developed and used for experiments. This paper attempts to pull together the technical details, achievements, and wisdom amassed during the intervening thirty years, and notes how we would push for increased performance in the future.

  6. Conference Committees: Conference Committees

    Science.gov (United States)

    2009-09-01

    International Programm Committee (IPC) Harald Ade NCSU Sadao Aoki University Tsukuba David Attwood Lawrence Berkeley National Laboratory/CXRO Christian David Paul Scherrer Institut Peter Fischer Lawrence Berkeley National Laboratory Adam Hitchcock McMaster University Chris Jacobsen SUNY, Stony Brook Denis Joyeux Lab Charles Fabry de l'Institut d'Optique Yasushi Kagoshima University of Hyogo Hiroshi Kihara Kansai Medical University Janos Kirz SUNY Stony Brook Maya Kiskinova ELETTRA Ian McNulty Argonne National Lab/APS Alan Michette Kings College London Graeme Morrison Kings College London Keith Nugent University of Melbourne Zhu Peiping BSRF Institute of High Energy Physics Francois Polack Soleil Christoph Quitmann Paul Scherrer Institut Günther Schmahl University Göttingen Gerd Schneider Bessy Hyun-Joon Shin Pohang Accelerator Lab Jean Susini ESRF Mau-Tsu Tang NSRRC Tony Warwick Lawrence Berkeley Lab/ALS Local Organizing Committee Christoph Quitmann Chair, Scientific Program Charlotte Heer Secretary Christian David Scientific Program Frithjof Nolting Scientific Program Franz Pfeiffer Scientific Program Marco Stampanoni Scientific Program Robert Rudolph Sponsoring, Financials Alfred Waser Industry Exhibition Robert Keller Public Relation Markus Knecht Computing and WWW Annick Cavedon Proceedings and Excursions and Accompanying Persons Program Margrit Eichler Excursions and Accompanying Persons Program Kathy Eikenberry Excursions and Accompanying Persons Program Marlies Locher Excursions and Accompanying Persons Program

  7. User-inspired design methodology using Affordance Structure Matrix (ASM for construction projects

    Directory of Open Access Journals (Sweden)

    Maheswari J. Uma

    2017-01-01

    Full Text Available Traditionally, design phase of construction projects is often performed with incomplete and inaccurate user preferences. This is due to inefficiencies in the methodologies used for capturing the user requirements that can subsequently lead to inconsistencies and result in non-optimised end-result. Iterations and subsequent reworks due to such design inefficiencies is one of the major reasons for unsuccessful project delivery as they impact project performance measures such as time and cost among others. The existing design theories and practice are primarily based on functional requirements. Function-based design deals with design of artifact alone, which may yield favourable or unfavourable consequences with the design artifact. However, incorporating other interactions such as interactions between user & designer is necessary for optimised end-result. Hence, the objective of this research work is to devise a systematic design methodology considering all the three interactions among users, designers and artefacts for improved design efficiency. In this study, it has been attempted to apply the theory of affordances in a case project that involves the design of an offshore facility. A step-by-step methodology for developing Affordance Structure Matrix (ASM, which integrates House of Quality (HOQ and Design Structure Matrix (DSM, is proposed that can effectively capture the user requirements. HOQ is a popular quality management tool for capturing client requirements and DSM is a matrix-based tool that can capture the interdependency among the design entities. The proposed methodology utilises the strengths of both the tools, as DSM compliments HOQ in the process. In this methodology, different affordances such as AUA (Artifact-User-Affordance, AAA (Artifact-Artifact-Affordance and DDA (Designer-Designer-Affordance are captured systematically. Affordance is considered to be user-driven in this context that is in contrast to prevailing design

  8. ACOG Committee Opinion No. 646: Ethical Considerations for Including Women as Research Participants.

    Science.gov (United States)

    2015-11-01

    Inclusion of women in research studies is necessary for valid inferences about health and disease in women. The generalization of results from trials conducted in men may yield erroneous conclusions that fail to account for the biologic differences between men and women. Although significant changes in research design and practice have led to an increase in the proportion of women included in research trials, knowledge gaps remain because of a continued lack of inclusion of women, especially those who are pregnant, in premarketing research trials. This document provides a historical overview of issues surrounding women as participants in research trials, followed by an ethical framework and discussion of the issues of informed consent, contraception requirements, intimate partner consent, and the appropriate inclusion of pregnant women in research studies.

  9. Symposium 'Methodology in Medical Education Research' organised by the Methodology in Medical Education Research Committee of the German Society of Medical Education May, 25th to 26th 2013 at Charité, Berlin.

    Science.gov (United States)

    Schüttpelz-Brauns, Katrin; Kiessling, Claudia; Ahlers, Olaf; Hautz, Wolf E

    2015-01-01

    In 2013, the Methodology in Medical Education Research Committee ran a symposium on "Research in Medical Education" as part of its ongoing faculty development activities. The symposium aimed to introduce to participants educational research methods with a specific focus on research in medical education. Thirty-five participants were able to choose from workshops covering qualitative methods, quantitative methods and scientific writing throughout the one and a half days. The symposium's evaluation showed participant satisfaction with the format as well as suggestions for future improvement. Consequently, the committee will offer the symposium again in a modified form in proximity to the next annual Congress of the German Society of Medical Education.

  10. Learning Disabilities: Implications for Policy regarding Research and Practice--A Report by the National Joint Committee on Learning Disabilities, March 2011

    Science.gov (United States)

    Learning Disabilities: A Multidisciplinary Journal, 2012

    2012-01-01

    The National Joint Committee on Learning Disabilities (NJCLD) affirms that the construct of learning disabilities represents a valid, unique, and heterogeneous group of disorders, and that recognition of this construct is essential for sound policy and practice. An extensive body of scientific research on learning disabilities continues to support…

  11. Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.

    Science.gov (United States)

    Xu, Ming; Zhang, Qiufang; Li, Pin-Lan; Nguyen, Thaison; Li, Xiang; Zhang, Yang

    2016-01-01

    Acid sphingomyelinase (ASM; gene symbol Smpd1) has been shown to play a crucial role in autophagy maturation by controlling lysosomal fusion with autophagosomes in coronary arterial smooth muscle cells (CASMCs). However, the underlying molecular mechanism by which ASM controls autophagolysosomal fusion remains unknown. In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release. In these CASMCs, ASM deficiency or TRPML1 gene silencing markedly inhibited 7-Ket-induced dynein activation. In addition, 7-Ket-induced autophagosome trafficking, an event associated with lysosomal Ca(2+) release and dynein activity, was significantly inhibited in ASM-deficient (Smpd1(-/-)) CASMCs compared to that in Smpd1(+/+) CASMCs. Finally, overexpression of TRPML1 proteins restored 7-Ket-induced lysosomal Ca(2+) release and autophagosome trafficking in Smpd1-/- CASMCs. Collectively, these results suggest that ASM plays a critical role in regulating lysosomal TRPML1-Ca(2+) signaling and subsequent dynein-mediated autophagosome trafficking, which leads its role in controlling autophagy maturation in CASMCs under atherogenic stimulation.

  12. Federal Council on Science, Engineering and Technology: Committee on Computer Research and Applications, Subcommittee on Science and Engineering Computing: The US Supercomputer Industry

    Energy Technology Data Exchange (ETDEWEB)

    1987-12-01

    The Federal Coordinating Council on Science, Engineering, and Technology (FCCSET) Committee on Supercomputing was chartered by the Director of the Office of Science and Technology Policy in 1982 to examine the status of supercomputing in the United States and to recommend a role for the Federal Government in the development of this technology. In this study, the FCCSET Committee (now called the Subcommittee on Science and Engineering Computing of the FCCSET Committee on Computer Research and Applications) reports on the status of the supercomputer industry and addresses changes that have occured since issuance of the 1983 and 1985 reports. The review based upon periodic meetings with and site visits to supercomputer manufacturers and consultation with experts in high performance scientific computing. White papers have been contributed to this report by industry leaders and supercomputer experts.

  13. 76 FR 74040 - Emerging Technology and Research Advisory Committee (ETRAC): Notice of Recruitment of Private...

    Science.gov (United States)

    2011-11-30

    ... Rule in the Era of Globalization, to the Secretary of Commerce. The DEAC recommended that BIS create a... senior officials with significant experience in business, educational research, and national...

  14. 75 FR 7481 - Meeting of the Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2010-02-19

    ... Menikoff, M.D., J.D., Director, Office for Human Research Protections (OHRP), or Julia Gorey, J.D... who plan to attend the meeting and need special assistance, such as sign language interpretation...

  15. ASME Non-Nuclear Authorization Certification and Recertification Requirements of Nondestructive Testing%ASME 非核授权证书取换证无损检测要求

    Institute of Scientific and Technical Information of China (English)

    金磊

    2015-01-01

    ASME 取换证过程中,无损检测作为质量保证的一部分,是 ASME 取换证过程中重要的一环。介绍在 ASME 非核授权证书取换证过程中涉及的 ASME 规范2013版中对无损检测的相关要求,给相关技术人员提供借鉴。%In the process of ASME certification and recertification,nondestructive testing as the part of the quality assurance is important.This paper introduces relevant requirements of nondestructive testing involved in ASME 2013 version in the process of the ASME certification and recertification for non-nuclear application,the technician can consult it.

  16. Cooperation between research institutions and journals on research integrity cases: Guidance from the committee on publication ethics.

    Science.gov (United States)

    Wager, Elizabeth; Kleinert, Sabine

    2012-04-01

    Institutions and journals both have important duties relating to research and publication misconduct. Institutions are responsible for the conduct of their researchers and for encouraging a healthy research environment. Journals are responsible for the conduct of their editors, for safeguarding the research record, and for ensuring the reliability of everything they publish. It is, therefore, important for institutions and journals to communicate and collaborate effectively on cases relating to research integrity. To achieve this, we make the following recommendations.The institutions should:have a research integrity officer (or office) and publish their contact details prominentlyinform journals about cases of proven misconduct that affect the reliability or attribution of the research that they have publishedrespond to journals if they request information about issues, such as, disputed authorship, misleading reporting, competing interests, or other factors, including honest errors, that could affect the reliability of the published studyinitiate inquiries into allegations of research misconduct or unacceptable publication practice raised by journalshave policies supporting a responsible research conduct and systems in place for investigating suspected research misconduct.The journals should:publish the contact details of their editor-in-chief who should act as the point of contact for questions relating to research and publication integrityinform institutions if they suspect misconduct by their researchers, and provide evidence to support these concernscooperate with investigations and respond to institutions' questions about misconduct allegationsbe prepared to issue retractions or corrections (according to the COPE guidelines on retractions) when provided with findings of misconduct arising from investigationshave policies for responding to institutions and other organizations that investigate cases of research misconduct.

  17. The Characteristics and Applied Limits for the Test Code ASME PTC6 and ASME PTC46%发电设备性能试验规程ASME PTC6与ASME PTC46的特点及适用范围

    Institute of Scientific and Technical Information of China (English)

    王兴平

    2003-01-01

    对美国机械工程师协会汽轮机及全厂性试验规程ASME PTC6与ASME PTC46的目的、方法、边界条件等作了分析论述,着重介绍了ASME PTC46的特点和方法,并根据国内的实际情况,并提出了实际应用方面的建议.表1参4

  18. Federal Coordinating Council on Science, Engineering and Technology, Committee on Computer Research and Applications, Subcommittee on Science and Engineering Computing: Annual report, 1987

    Energy Technology Data Exchange (ETDEWEB)

    1988-03-01

    In the past year the committee initiated efforts that resulted in the report ''A Research and Development Strategy for High Performance Computing'' and will presently provide a government-wide implementation plan to address the technological opportunities possible with the achievement of significantly enhanced supercomputer capability. The committee met on a regular basis to review government supported programs in research, development and application of new supercomputer technology. The Committee annually visits supercomputer manufacturers to be briefed on their plans for future generation machines. Cray Research and ETA Systems continue to make progress toward developing more advanced supercomputers. The US supercomputer manufacturers remain dependent upon their emerging Japanese competitors for high performance IC'S although progress has been made toward achieving more adequate domestic sourcing. Reports by the Defense Science Board and the National Security Council/Economic Policy Council, which addressed semiconductor issues, were completed during the year with advice and input from the Committee. IBM has re-entered the supercomputer marketplace. The current 3090 series with expandable vector processing capability has achieved a low end position in the supercomputer performance spectrum. Subsequent development and marketing by IBM of more powerful machines would have important and far reaching impact on the domestic and world supercomputer market. Computers with massively parallel architecture--thousands of processors--are entering the market place and are beginning to become more of a factor in the computational productivity scale.

  19. Cooperation between research institutions and journals on research integrity cases: guidance from the committee on publication ethics (cope).

    Science.gov (United States)

    Wager, Elizabeth; Kleinert, Sabine

    2012-09-01

    Institutions and journals both have important duties relating to research and publication misconduct. Institutions are responsible for the conduct of their researchers and for encouraging a healthy research environment. Journals are responsible for the conduct of their editors, for safeguarding the research record, and for ensuring the reliability of everything they publish. It is therefore important for institutions and journals to communicate and collaborate effectively on cases relating to research integrity. To achieve this, we make the following recommendations. Institutions should: have a research integrity officer (or office) and publish their contact details prominently; inform journals about cases of proven misconduct that affect the reliability or attribution of work that they have published; respond to journals if they request information about issues, such as disputed authorship, misleading reporting, competing interests, or other factors, including honest errors, that could affect the reliability of published work; initiate inquiries into allegations of research misconduct or unacceptable publication practice raised by journals; have policies supporting responsible research conduct and systems in place for investigating suspected research misconduct.Journals should: publish the contact details of their editor-in-chief who should act as the point of contact for questions relating to research and publication integrity; inform institutions if they suspect misconduct by their researchers, and provide evidence to support these concerns; cooperate with investigations and respond to institutions' questions about misconduct allegations; be prepared to issue retractions or corrections (according to the COP E guidelines on retractions) when provided with findings of misconduct arising from investigations; have policies for responding to institutions and other organizations that investigate cases of research misconduct.

  20. The ASM Curriculum Guidelines for Undergraduate Microbiology: A Case Study of the Advocacy Role of Societies in Reform Efforts.

    Science.gov (United States)

    Horak, Rachel E A; Merkel, Susan; Chang, Amy

    2015-05-01

    A number of national reports, including Vision and Change in Undergraduate Biology Education: A Call to Action, have called for drastic changes in how undergraduate biology is taught. To that end, the American Society for Microbiology (ASM) has developed new Curriculum Guidelines for undergraduate microbiology that outline a comprehensive curriculum for any undergraduate introductory microbiology course or program of study. Designed to foster enduring understanding of core microbiology concepts, the Guidelines work synergistically with backwards course design to focus teaching on student-centered goals and priorities. In order to qualitatively assess how the ASM Curriculum Guidelines are used by educators and learn more about the needs of microbiology educators, the ASM Education Board distributed two surveys to the ASM education community. In this report, we discuss the results of these surveys (353 responses). We found that the ASM Curriculum Guidelines are being implemented in many different types of courses at all undergraduate levels. Educators indicated that the ASM Curriculum Guidelines were very helpful when planning courses and assessments. We discuss some specific ways in which the ASM Curriculum Guidelines have been used in undergraduate classrooms. The survey identified some barriers that microbiology educators faced when trying to adopt the ASM Curriculum Guidelines, including lack of time, lack of financial resources, and lack of supporting resources. Given the self-reported challenges to implementing the ASM Curriculum Guidelines in undergraduate classrooms, we identify here some activities related to the ASM Curriculum Guidelines that the ASM Education Board has initiated to assist educators in the implementation process.

  1. 76 FR 76417 - Office of Planning, Research and Evaluation Advisory Committee on Head Start Research and Evaluation

    Science.gov (United States)

    2011-12-07

    ... research efforts to inform HHS about how to guide the development and implementation of best practices in... report for the Head Start Impact Study, offering interpretations of the findings, discussing implications for practice and policy, and providing recommendations on follow-up research, including additional...

  2. Ethical issues in genomic research on the African continent: experiences and challenges to ethics review committees.

    Science.gov (United States)

    Ramsay, Michèle; de Vries, Jantina; Soodyall, Himla; Norris, Shane A; Sankoh, Osman

    2014-01-01

    This is a report on a workshop titled 'Ethics for genomic research across five African countries: Guidelines, experiences and challenges', University of the Witwatersrand, Johannesburg, South Africa, 10 and 11 December 2012. The workshop was hosted by the Wits-INDEPTH partnership, AWI-Gen, as part of the H3Africa Consortium.

  3. 77 FR 6799 - Meeting of the Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2012-02-09

    ... Bioethical Issues on that group's recent report Moral Science: Protecting Participants in Human Subjects... Secretary for Health on issues and topics pertaining to or associated with the protection of human research..., SACHRP, prior to the close of business February 23, 2012. Dated: February 3, 2012. Jerry Menikoff...

  4. Partial Support for the Federal Committee for Meteorological Services and Supporting Research

    Energy Technology Data Exchange (ETDEWEB)

    Williamson, Samuel P

    2012-04-30

    DOE E-link Report Number DOE/ER62778 1999-2012 Please see attached Final Technical Report (size too large to post here). Annual Products Provided to DOE: Federal Plan for Meteorological Services and Supporting Research; National Hurricane Operations Plan; Interdepartmental Hurricane Conference Summary Report. All reports and publications can be found on the OFCM website, www.ofcm.noaa.gov.

  5. 78 FR 52080 - Potato Research and Promotion Plan; Amend the Administrative Committee Structure and Delete the...

    Science.gov (United States)

    2013-08-22

    .... Interested persons wanting to contact the Board can reach them through their Web site, Facebook, or... amendments to the regulations. The Board can easily be contacted by using their Web site, Facebook or... proposed rule. List of Subjects in 7 CFR Part 1207 Advertising, Agricultural research, Imports,...

  6. 76 FR 42712 - Advisory Committee on Head Start Research and Evaluation

    Science.gov (United States)

    2011-07-19

    ... findings, discussing implications for practice and policy, and providing recommendations on follow-up... implementation of best practices in Head Start and other early childhood programs around the country. DATES: The... childhood programs by enhancing the use of research-informed practices in early childhood. Finally, the...

  7. National Kitchen Research Survey. A Report to the Curricula Advisory Committee.

    Science.gov (United States)

    National Craft Curricula and Certification Board for the Hotel, Catering and Tourism Industry, Dublin (Ireland).

    In 1983, as part of its overall review of craft catering education and training in Ireland, the National Craft Curricula and Certification Board commissioned a nationwide research study of the trends and developments in professional kitchen practice in all sectors of the hotel and catering industry. The study was conducted through interviews with…

  8. 76 FR 11248 - Secretary's Advisory Committee on Human Research Protections; Notice of Meeting

    Science.gov (United States)

    2011-03-01

    ...: Jerry Menikoff, M.D., J.D., Director, Office for Human Research Protections, or Julia Gorey, J.D..., Rockville, Maryland 20852; 240-453-6900, fax: 240-453-6909; e-mail address: Julia.Gorey@hhs.gov... as sign language interpretation or other reasonable accommodations, should notify the...

  9. National Kitchen Research Survey. A Report to the Curricula Advisory Committee.

    Science.gov (United States)

    National Craft Curricula and Certification Board for the Hotel, Catering and Tourism Industry, Dublin (Ireland).

    In 1983, as part of its overall review of craft catering education and training in Ireland, the National Craft Curricula and Certification Board commissioned a nationwide research study of the trends and developments in professional kitchen practice in all sectors of the hotel and catering industry. The study was conducted through interviews with…

  10. 78 FR 40743 - Mine Safety and Health Research Advisory Committee, National Institute for Occupational Safety...

    Science.gov (United States)

    2013-07-08

    ... trade literature; a plan for periodically updating the demographic survey of the mining industry; an analysis of the research needs of the stone, sand and gravel sector; reinventing deep vein mining to... Laboratory; a presentation on emerging lithium batteries; and findings for improving rock dusting...

  11. Rules Governing Female Professionals——Symposium sponsored by the Working Committee of Professional Women, under the China Personnel Research Association

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    THE number of nongovernmental women’s organizations in China has increased dramatically in recent years. The long list includes friendship organizations of women in the same trade and a number of academic research associations. The Working Committee on Female Professionals, under China Personnel Research Association represents on the major national academic women’s societies. The association’s goal is to study problems confronting female professional women, establishing for

  12. Equilíbrio corporal em crianças e adolescentes asmáticos e não asmáticos

    OpenAIRE

    Marta Cristina Rodrigues da Silva; Sara Teresinha Corazza; Juliana Izabel Katzer; Carlos Bolli Mota; Juliana Côrrea Soares

    2013-01-01

    O objetivo foi analisar e comparar o equilíbrio corporal em crianças e adolescentes asmáticos e não asmáticos. Fizeram parte do grupo de estudos 24 sujeitos com idades de 7 a 14 anos divididos em dois grupos: grupo asmático e grupo controle. Para avaliação do equilíbrio corporal utilizou-se uma plataforma de força. Foram utilizadas as condições, olhos abertos e fechados com três tentativas aleatórias, com duração de 30 segundos cada uma. Os resultados apontaram diferença significativa entre o...

  13. 115-year-old society knows how to reach young scientists: ASM Young Ambassador Program.

    Science.gov (United States)

    Karczewska-Golec, Joanna

    2015-12-25

    With around 40,000 members in more than 150 countries, American Society for Microbiology (ASM) faces the challenge of meeting very diverse needs of its increasingly international members base. The newly launched ASM Young Ambassador Program seeks to aid the Society in this effort. Equipped with ASM conceptual support and financing, Young Ambassadors (YAs) design and pursue country-tailored approaches to strengthen the Society's ties with local microbiological communities. In a trans-national setting, the active presence of YAs at important scientific events, such as 16th European Congress on Biotechnology, forges new interactions between ASM and sister societies. The paper presents an overview of the Young Ambassadors-driven initiatives at both global and country levels, and explores the topic of how early-career scientists can contribute to science diplomacy and international relations.

  14. High Level Analysis, Design and Validation of Distributed Mobile Systems with CoreASM

    Science.gov (United States)

    Farahbod, R.; Glässer, U.; Jackson, P. J.; Vajihollahi, M.

    System design is a creative activity calling for abstract models that facilitate reasoning about the key system attributes (desired requirements and resulting properties) so as to ensure these attributes are properly established prior to actually building a system. We explore here the practical side of using the abstract state machine (ASM) formalism in combination with the CoreASM open source tool environment for high-level design and experimental validation of complex distributed systems. Emphasizing the early phases of the design process, a guiding principle is to support freedom of experimentation by minimizing the need for encoding. CoreASM has been developed and tested building on a broad scope of applications, spanning computational criminology, maritime surveillance and situation analysis. We critically reexamine here the CoreASM project in light of three different application scenarios.

  15. Review of ASME-NH Design Materials for Creep-Fatigue

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Gyeong Hoi; Kim, Jong Bum [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2010-05-15

    To review and recommend the candidate design materials for the Sodium-Cooled Fast Reactor, the material sensitivity evaluations by the comparison of design data between the ASME-NH materials were performed by using the SIE ASME-NH computer program implementing the material database of the ASME-NH. The design material data provided by the ASME-NH code are the elastic modulus and yield Strength, Time-Independent Allowable Stress Intensity value, time-dependent allowable stress intensity value, expected minimum stress-to rupture value, stress rupture Factors for weldment, isochronous stress-strain curves, and design fatigue curves. Among these, the data related with the creep-fatigue evaluation are investigated in this study

  16. The First ASME Code Stamped Cryomodule at SNS

    Energy Technology Data Exchange (ETDEWEB)

    Howell, M P; Crofford, M T; Douglas, D L; Kim, S -H; Steward, S T; Strong, W H; Afanador, R; Hannah, B S; Saunders, J

    2012-07-01

    The first spare cryomodule for the Spallation Neutron Source (SNS) has been designed, fabricated, and tested by SNS personnel. The approach to design for this cryomodule was to hold critical design features identical to the original design such as bayonet positions, coupler positions, cold mass assembly, and overall footprint. However, this is the first SNS cryomodule that meets the pressure requirements put forth in the 10 CFR 851: Worker Safety and Health Program. The most significant difference is that Section VIII of the ASME Boiler and Pressure Vessel Code was applied to the vacuum vessel of this cryomodule. Applying the pressure code to the helium vessels within the cryomodule was considered. However, it was determined to be schedule prohibitive because it required a code case for materials that are not currently covered by the code. Good engineering practice was applied to the internal components to verify the quality and integrity of the entire cryomodule. The design of the cryomodule, fabrication effort, and cryogenic test results will be reported in this paper.

  17. Electric Power Research Institute Environmental Control Technology Center Report to the Steering Committee

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1998-01-12

    Operations and maintenance continued this month at the Electric Power Research Institute's (EPRI's) Environmental Control Technology Center (ECTC). Testing for the month involved the Dry Sorbent Injection (DSI) test block with the Carbon Injection System. The 1.0 MW Cold-Side Selective Catalytic Reduction (SCR) unit, the 0.4 MW Mini-Pilot Wet Scrubber, and the 4.0 MW Pilot Wet Scrubber remained idle this month in a cold-standby mode and were inspected regularly. These units remain available for testing as future project work is identified.

  18. Review and Recommendations for the Interagency Ship Structure Committee’s Fiscal 1984 Research Program,

    Science.gov (United States)

    1983-01-01

    E. I. DuPont de Nemours & Company Center for Law and Social Policy Wilmington, Delaware Washington, D.C. Eric Schenker CRobert G. Dean University of...Naval Sa UniUd Stan Mitiiw Miliary phW~ B ureau of jSysuMs COWt Guard Aillnalilt serviceif S96. prq Commaind IoWw sevc 1.~Pk b Mkingsns SHIP STRUCTURE...approves program plans, and provides financial support through its member agencies for the research program. A maximum of four representatives from

  19. Electric Power Research Institute, Environmental Control Technology Center monthly report to the Steering Committee, June 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-11-02

    Operations and maintenance continued this month at the Electric Power Research Institute`s Environmental Control Technology Center. Testing on the 4.0 MW Pilot FGD unit continued this month with High Velocity Scrubbing and the Tampa Electric Company (TECO) Tailored Collaboration test block. Additionally, Phase III of the Toxics Removal/Carbon Injection test block was conducted concurrently with FGD testing. At the beginning of the month, a second phase of third-party testing began for Suncor, Inc. The Suncor Gypsum Sample Collection test block (MSUN) began on June 5 on the 0.4 MW Mini-Pilot Wet FGD unit. Testing was completed on June 13. On the Cold-Side Selective Catalytic Reduction (SCR) unit, testing continued this month as ammonia slip measurements were conducted under low catalyst inlet temperatures and at baseline conditions.

  20. [International regulation of ethics committees on biomedical research as protection mechanisms for people: analysis of the Additional Protocol to the Convention on Human Rights and Biomedicine, concerning Biomedical Research of the Council of Europe].

    Science.gov (United States)

    de Lecuona, Itziar

    2013-01-01

    The article explores and analyses the content of the Council of Europe's Additional Protocol to the Convention on Human Rights and Biomedicine concerning Biomedical Research regarding the standard legal instrument in biomedical research, issued by an international organization with leadership in bioethics. This implies ethics committees are mechanisms of protection of humans in biomedical research and not mere bureaucratic agencies and that a sound inescapable international regulatory framework exists for States to regulate biomedical research. The methodology used focuses on the analysis of the background, the context in which it is made and the nature and scope of the Protocol. It also identifies and analyses the characteristics and functions of ethics committees in biomedical research and, in particular, the information that should be provided to this bodies to develop their functions previously, during and at the end of research projects. This analysis will provide guidelines, suggestions and conclusions for the awareness and training of members of these committees in order to influence the daily practice. This paper may also be of interest to legal practitioners who work in different areas of biomedical research. From this practical perspective, the article examines the legal treatment of the Protocol to meet new challenges and classic issues in research: the treatment of human biological samples, the use of placebos, avoiding double standards, human vulnerability, undue influence and conflicts of interest, among others. Also, from a critical view, this work links the legal responses to develop work procedures that are required for an effective performance of the functions assigned of ethics committees in biomedical research. An existing international legal response that lacks doctrinal standards and provides little support should, however, serve as a guide and standard to develop actions that allow ethics committees -as key bodies for States- to advance in

  1. A Minimal Path Searching Approach for Active Shape Model (ASM)-based Segmentation of the Lung.

    Science.gov (United States)

    Guo, Shengwen; Fei, Baowei

    2009-03-27

    We are developing a minimal path searching method for active shape model (ASM)-based segmentation for detection of lung boundaries on digital radiographs. With the conventional ASM method, the position and shape parameters of the model points are iteratively refined and the target points are updated by the least Mahalanobis distance criterion. We propose an improved searching strategy that extends the searching points in a fan-shape region instead of along the normal direction. A minimal path (MP) deformable model is applied to drive the searching procedure. A statistical shape prior model is incorporated into the segmentation. In order to keep the smoothness of the shape, a smooth constraint is employed to the deformable model. To quantitatively assess the ASM-MP segmentation, we compare the automatic segmentation with manual segmentation for 72 lung digitized radiographs. The distance error between the ASM-MP and manual segmentation is 1.75 ± 0.33 pixels, while the error is 1.99 ± 0.45 pixels for the ASM. Our results demonstrate that our ASM-MP method can accurately segment the lung on digital radiographs.

  2. A minimal path searching approach for active shape model (ASM)-based segmentation of the lung

    Science.gov (United States)

    Guo, Shengwen; Fei, Baowei

    2009-02-01

    We are developing a minimal path searching method for active shape model (ASM)-based segmentation for detection of lung boundaries on digital radiographs. With the conventional ASM method, the position and shape parameters of the model points are iteratively refined and the target points are updated by the least Mahalanobis distance criterion. We propose an improved searching strategy that extends the searching points in a fan-shape region instead of along the normal direction. A minimal path (MP) deformable model is applied to drive the searching procedure. A statistical shape prior model is incorporated into the segmentation. In order to keep the smoothness of the shape, a smooth constraint is employed to the deformable model. To quantitatively assess the ASM-MP segmentation, we compare the automatic segmentation with manual segmentation for 72 lung digitized radiographs. The distance error between the ASM-MP and manual segmentation is 1.75 +/- 0.33 pixels, while the error is 1.99 +/- 0.45 pixels for the ASM. Our results demonstrate that our ASM-MP method can accurately segment the lung on digital radiographs.

  3. Research Committee. New Assessments for New Standards: The Potential Transformation of Mathematics Education and Its Research Implications

    Science.gov (United States)

    Tarr, James E.; Walker, Erica N.; Hollebrands, Karen F.; Chval, Kathryn B.; Berry, Robert Q., III; Rasmussen, Chris L.; Konold, Cliff; King, Karen

    2013-01-01

    The current era of common curriculum standards, increased accountability, and rapid expansion of technology within a complex and highly charged political context has influenced changes in assessment practices in mathematics classrooms. This research commentary situates high-stakes assessments in a historical context, discusses recent advances in…

  4. 76 FR 17130 - Office of Planning, Research and Evaluation Advisory Committee on Head Start Research and Evaluation

    Science.gov (United States)

    2011-03-28

    ... of the findings, discussing implications for practice and policy, and providing recommendations on... implementation of best practices in Head Start and other early childhood programs around the country. DATES: The... early childhood programs by enhancing the use of research-informed practices in early childhood. Finally...

  5. 76 FR 789 - Office of Planning, Research and Evaluation Advisory Committee on Head Start Research and Evaluation

    Science.gov (United States)

    2011-01-06

    ... of the findings, discussing implications for practice and policy, and providing recommendations on... implementation of best practices in Head Start and other early childhood programs around the country. DATES: The... early childhood programs by enhancing the use of research-informed practices in early childhood. Finally...

  6. Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195

    NARCIS (Netherlands)

    Sechopoulos, I.; Ali, E.S.; Badal, A.; Badano, A.; Boone, J.M.; Kyprianou, I.S.; Mainegra-Hing, E.; McMillan, K.L.; McNitt-Gray, M.F.; Rogers, D.W.; Samei, E.; Turner, A.C.

    2015-01-01

    The use of Monte Carlo simulations in diagnostic medical imaging research is widespread due to its flexibility and ability to estimate quantities that are challenging to measure empirically. However, any new Monte Carlo simulation code needs to be validated before it can be used reliably. The type a

  7. Biomedical Challenges Presented by the American Indian, Proceedings of the Special Session of the PAHO Advisory Committee on Medical Research (7th, Washington, D.C., June 25, 1968).

    Science.gov (United States)

    Pan American Health Organization, Washington, DC.

    At each meeting of the Pan American Health Organization Advisory Committee on Medical Research, a special 1-day session is held on a topic chosen by the committee as being of particular interest. At the 7th meeting, which convened in June of 1968 in Washington, D.C., the session surveyed the origin, present distribution, and principal biological…

  8. Extent of non-publication in cohorts of studies approved by research ethics committees or included in trial registries.

    Directory of Open Access Journals (Sweden)

    Christine Schmucker

    Full Text Available BACKGROUND: The synthesis of published research in systematic reviews is essential when providing evidence to inform clinical and health policy decision-making. However, the validity of systematic reviews is threatened if journal publications represent a biased selection of all studies that have been conducted (dissemination bias. To investigate the extent of dissemination bias we conducted a systematic review that determined the proportion of studies published as peer-reviewed journal articles and investigated factors associated with full publication in cohorts of studies (i approved by research ethics committees (RECs or (ii included in trial registries. METHODS AND FINDINGS: Four bibliographic databases were searched for methodological research projects (MRPs without limitations for publication year, language or study location. The searches were supplemented by handsearching the references of included MRPs. We estimated the proportion of studies published using prediction intervals (PI and a random effects meta-analysis. Pooled odds ratios (OR were used to express associations between study characteristics and journal publication. Seventeen MRPs (23 publications evaluated cohorts of studies approved by RECs; the proportion of published studies had a PI between 22% and 72% and the weighted pooled proportion when combining estimates would be 46.2% (95% CI 40.2%-52.4%, I2 = 94.4%. Twenty-two MRPs (22 publications evaluated cohorts of studies included in trial registries; the PI of the proportion published ranged from 13% to 90% and the weighted pooled proportion would be 54.2% (95% CI 42.0%-65.9%, I2 = 98.9%. REC-approved studies with statistically significant results (compared with those without statistically significant results were more likely to be published (pooled OR 2.8; 95% CI 2.2-3.5. Phase-III trials were also more likely to be published than phase II trials (pooled OR 2.0; 95% CI 1.6-2.5. The probability of publication within two

  9. Summary of proceedings of the first meeting of the executive committee on building and community systems. Electricity council Research Centre, Capenhurst, United Kingdom

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-01-01

    The International Energy Agency (IEA) meeting on Building and Community Systems was conducted in three phases. First, participants toured the Electricity Council Research Centre (ECRC) research facilities to observe the ECRC's building research activities and to receive information on their ongoing research into energy usage in buildings. The final meeting of the Experts Group on Building and Community Systems was then held on May 4. During this meeting, analysts discussed the progress of their analysis of office buildings that has been conducted since the October, 1976, Experts Group meeting in Stockholm. In accordance with IEA rules, this Experts Group was then abolished and an Executive Committee on Buildings and Community Systems created to direct further work in this project area. This action reflects the signing in March of the Implementing Agreement on Building and Community Systems and Annex I on Thermal Characteristics by the United States, Canada, and Italy. The discussion of study activities, begun by the Experts Group, was continued at this Executive Committee meeting. Sections I and II describe the meetings of the Experts Group and Executive Committee. Section III describes the field trip at the ECRC.

  10. Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195.

    Science.gov (United States)

    Sechopoulos, Ioannis; Ali, Elsayed S M; Badal, Andreu; Badano, Aldo; Boone, John M; Kyprianou, Iacovos S; Mainegra-Hing, Ernesto; McMillan, Kyle L; McNitt-Gray, Michael F; Rogers, D W O; Samei, Ehsan; Turner, Adam C

    2015-10-01

    The use of Monte Carlo simulations in diagnostic medical imaging research is widespread due to its flexibility and ability to estimate quantities that are challenging to measure empirically. However, any new Monte Carlo simulation code needs to be validated before it can be used reliably. The type and degree of validation required depends on the goals of the research project, but, typically, such validation involves either comparison of simulation results to physical measurements or to previously published results obtained with established Monte Carlo codes. The former is complicated due to nuances of experimental conditions and uncertainty, while the latter is challenging due to typical graphical presentation and lack of simulation details in previous publications. In addition, entering the field of Monte Carlo simulations in general involves a steep learning curve. It is not a simple task to learn how to program and interpret a Monte Carlo simulation, even when using one of the publicly available code packages. This Task Group report provides a common reference for benchmarking Monte Carlo simulations across a range of Monte Carlo codes and simulation scenarios. In the report, all simulation conditions are provided for six different Monte Carlo simulation cases that involve common x-ray based imaging research areas. The results obtained for the six cases using four publicly available Monte Carlo software packages are included in tabular form. In addition to a full description of all simulation conditions and results, a discussion and comparison of results among the Monte Carlo packages and the lessons learned during the compilation of these results are included. This abridged version of the report includes only an introductory description of the six cases and a brief example of the results of one of the cases. This work provides an investigator the necessary information to benchmark his/her Monte Carlo simulation software against the reference cases included here

  11. Twelve Years of Acoustical Research. American School Band Directors' Association, Research Committee Reports for the 17th Annual Convention, Hot Springs, Arkansas, 1969.

    Science.gov (United States)

    American School Band Directors Association, Newark, OH.

    The guide, one in a series of committee reports relating to school band performance, organization, and equipment needs, discusses acoustical problems inherent to the clarinet. The report is presented in five sections. Section I summarizes findings of an American School Band Directors' Association (ASBDA) clarinet testing committee. A major finding…

  12. Audit Committees

    OpenAIRE

    2009-01-01

    We have produced this booklet to explain the role of audit committees as they can help to improve how an organisation is governed. In a company, an audit committee is a group of its directors whose main responsibilities are to: advise all directors about the quality of the company’s financial statements; work with the company’s external auditor; and examine the reports of the company’s internal auditor, if it employs one.

  13. Report to the Nuclear energy Research Advisory Committee (NERAC) Subcommittee on "Long-Term Isotope Research and Productions Plan" - Responses to Questions

    Energy Technology Data Exchange (ETDEWEB)

    Ammoniums

    1999-07-01

    This report presents responses to two series of questions that were raised by a subcommittee of the Nuclear Energy Research Advisory Committee (NERAC) that has been charged with producing a ''Long-Term Isotope Research and Production Plan.'' The NERAC subcommittee is chaired by Dr. Richard Reba, and the Hanford Site Visit team, which comprises a subset of the subcommittee members, is chaired by Dr. Thomas Ruth. The first set of questions raised by the subcommittee on isotope production at the Hanford Site was received from Dr. Ruth on May 10, 1999, and the second set was received from him on July 5, 1999. Responses to the first set of questions were prepared as part of a June 1999 report entitled ''Isotope Production at the Hanford Site in Richland, Washington'' (PNNL 1999a). The responses to these questions are summarized in this document, with frequent references to the June 1999 report for additional details. Responses to the second set of questions from the NERAC subcommittee are presented in this document for the first time.

  14. 使用ASME Ⅷ-2规范进行容器建造的基本原则%Basic Principle of Application of ASME Ⅷ-2 Code in Vessel Construction

    Institute of Scientific and Technical Information of China (English)

    于志刚; 董方亮

    2009-01-01

    针对使用ASME Ⅷ-2规范进行容器建造的实际需要,介绍了ASME Ⅷ-2规范的基本原理,分析了ASMEⅧ-2规范的基本要素,总结了按照ASME Ⅷ-2规范进行设计、建造的一些基本要点.

  15. Radiation in MRC supported research in the 1950s and 1960s. Report of a committee inquiry[Medical research; Radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    On 6 July 1995, a television documentary entitled 'Deadly Experiments' was broadcast on Channel 4 as part of the 'True Stories' series. The programme, produced by Twenty-Twenty Television, featured a number of research projects conducted between 1950 and 1970 in which either measurements were made of the amount of radiation absorbed by, or radioactive substances were administered to, human subjects in the UK and USA. The level of public concern generated by the broadcast and the implication of unethical practices in the conduct of some of the research sponsored by the MRC, has acted as the trigger for the MRC to establish this independent Committee of Inquiry. Its remit has been to clarify the facts surrounding the research and to examine issues of 'acceptability and consent in the context of the scientific and ethical standards of the period in, which the research was carried out. The following studies featured in the programme were funded by the MRC. The study measuring levels of Strontium 90 uptake, in which samples of bone were taken at autopsy (the programme featured a case in North Wales where the femora were removed from a deceased infant). The work carried out at University College London and reported in 1952 and 1958, in which radioiodine was administered to women in order to measure thyroid function throughout the menstrual cycle and in pregnancy. The work carried out at the Hammersmith Hospital, London, in 1953, in which radioactive sodium was used to measure maternal placental blood flow in normal and hypertensive women. The studies at Aberdeen Maternity Hospital, which investigated iodine metabolism and maternal thyroid function during pregnancy, and the development of the human fetal thyroid. The Coventry study in which women from the Asian community were asked to consume specially prepared chapattis in order to measure levels of iron absorption, with a view to investigating the problem of anaemia.

  16. Research for AGRI Committee

    NARCIS (Netherlands)

    Berge, ten H.F.M.; Schroder, J.J.; Olesen, Jørgen Eivind; Giraldez Cervera, J.V.

    2017-01-01

    This study explains how threats to soils and soil services are linked to agricultural soil management, how threats can be mitigated, and which barriers complicate this. It highlights trade-offs and synergies that exist between different interests affected by soil management, such as climate change

  17. 46 CFR 56.01-5 - Adoption of ASME B31.1 for power piping, and other standards.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of ASME B31.1 for power piping, and other... ENGINEERING PIPING SYSTEMS AND APPURTENANCES General § 56.01-5 Adoption of ASME B31.1 for power piping, and... accordance with ASME B31.1 (incorporated by reference; see 46 CFR 56.01-2), as limited, modified, or...

  18. ASME code considerations for the compact heat exchanger

    Energy Technology Data Exchange (ETDEWEB)

    Nestell, James [MPR Associates Inc., Alexandria, VA (United States); Sham, Sam [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-08-31

    robustness. Classic shell and tube designs will be large and costly, and may only be appropriate in steam generator service in the SHX where boiling inside the tubes occurs. For other energy conversion systems, all of these features can be met in a compact heat exchanger design. This report will examine some of the ASME Code issues that will need to be addressed to allow use of a Code-qualified compact heat exchanger in IHX or SHX nuclear service. Most effort will focus on the IHX, since the safety-related (Class A) design rules are more extensive than those for important-to-safety (Class B) or commercial rules that are relevant to the SHX.

  19. Dr. Hans Chang, Director, Physics Research Committee, Stichting voor Fundamenteel Onderzoek der Materie (FOM), Dr. Joris Van Enst, Head of Science Policy Division, Ministry of Education, Culture and S cience, Dr. Jan Bezemer, NL Delegate CERN, Netherlands

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    Dr. Hans Chang, Director, Physics Research Committee, Stichting voor Fundamenteel Onderzoek der Materie (FOM), Dr. Joris Van Enst, Head of Science Policy Division, Ministry of Education, Culture and S cience, Dr. Jan Bezemer, NL Delegate CERN, Netherlands

  20. A Retrospective Look at 20 Years of ASM Education Programs (1990-2010) and a Prospective Look at the Next 20 Years (2011-2030).

    Science.gov (United States)

    Chang, Amy

    2011-01-01

    Professional societies provide visibility and legitimacy to the work of their post secondary educator members, advocate best practices in courses and sponsored student research, and establish deep networks and communities that catalyze members to collectively engage in undergraduate teaching and learning scholarship. Within the American Society for Microbiology (ASM), the Education Board, established in the mid-1970s, assumes this role. I have been fortunate enough to watch several pivotal programs support our growth and change the status quo by providing opportunities for biology educators to flourish. In this retrospective review, the background and details I offer about each initiative help explain ASM Education offerings, how our growth has been supported and how the status quo has changed. In this prospective look, I offer my vision of the future in post secondary education where classroom learning is student-centered and focused on global problems affecting our health and environment. For the profession to proliferate, the ASM must provide members as many opportunities in learning biology as they do with advancing biology to new frontiers.

  1. US medical researchers, the Nuremberg Doctors Trial, and the Nuremberg Code. A review of findings of the Advisory Committee on Human Radiation Experiments.

    Science.gov (United States)

    Faden, R R; Lederer, S E; Moreno, J D

    1996-11-27

    The Advisory Committee on Human Radiation Experiments (ACHRE), established to review allegations of abuses of human subjects in federally sponsored radiation research, was charged with identifying appropriate standards to evaluate the ethics of cold war radiation experiments. One central question for ACHRE was to determine what role, if any, the Nuremberg Code played in the norms and practices of US medical researchers. Based on the evidence from ACHRE's Ethics Oral History Project and extensive archival research, we conclude that the Code, at the time it was promulgated, had little effect on mainstream medical researchers engaged in human subjects research. Although some clinical investigators raised questions about the conduct of research involving human beings, the medical profession did not pursue this issue until the 1960s.

  2. 76 FR 76937 - Emerging Technology and Research Advisory Committee; Notice of Partially Closed Meeting-Room Change

    Science.gov (United States)

    2011-12-09

    ... serve basis. To join the conference, submit inquiries to Ms. Yvette Springer at Yvette.Springer@bis.doc.... Springer via email. The Assistant Secretary for Administration, with the concurrence of the delegate of the... information, call Yvette Springer at (202) 482-2813. Dated: December 5, 2011. Yvette Springer, Committee...

  3. Symposium 'methodology in medical education research' organised by the Methodology in Medical Education Research Committee of the German Society of Medical Education May, 25 to 26 2013 at Charité, Berlin

    Directory of Open Access Journals (Sweden)

    Schüttpelz-Brauns, Katrin

    2015-02-01

    Full Text Available In 2013, the Methodology in Medical Education Research Committee ran a symposium on “Research in Medical Education” as part of its ongoing faculty development activities. The symposium aimed to introduce to participants educational research methods with a specific focus on research in medical education. Thirty-five participants were able to choose from workshops covering qualitative methods, quantitative methods and scientific writing throughout the one and a half days. The symposium’s evaluation showed participant satisfaction with the format as well as suggestions for future improvement. Consequently, the committee will offer the symposium again in a modified form in proximity to the next annual Congress of the German Society of Medical Education.

  4. Roles of the Outer Membrane Protein AsmA of Salmonella enterica in the Control of marRAB Expression and Invasion of Epithelial Cells▿

    OpenAIRE

    Ramos Morales, Francisco; Prieto Ortega, Ana Isabel; Hernández Piñero, Sara Belén; Cota García, Ignacio; Pucciarelli, María Graciela; Orlov, Yuri; García del Portillo, Francisco; Casadesús Pursals, José

    2009-01-01

    A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA gene. Disruption of asmA suppressed bile sensitivity also in phoP and wec mutants of S. enterica and increased the MIC of sodium deoxycholate for the parental strain ATCC 14028. Increased levels of marA mRNA were found in asmA, asmA dam, asmA phoP, and asmA wec strains of S....

  5. 77 FR 29667 - Blood Products Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-05-18

    ... No. FDA-2012-N-0001] Blood Products Advisory Committee; Notice of Meeting AGENCY: Food and Drug... public. Name of Committee: Blood Products Advisory Committee. General Function of the Committee: To..., Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA. FDA intends...

  6. Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition.

    Science.gov (United States)

    Allen, Jodi C; Seidel, Petra; Schlosser, Tobias; Ramsay, Emma E; Ge, Qi; Ammit, Alaina J

    2012-01-01

    Hyperplasia of airway smooth muscle (ASM) is a feature of the remodelled airway in asthmatics. We examined the antiproliferative effectiveness of the corticosteroid dexamethasone on expression of the key regulator of G(1) cell cycle progression-cyclin D1-in ASM cells from nonasthmatics and asthmatics stimulated with the mitogen platelet-derived growth factor BB. While cyclin D1 mRNA and protein expression were repressed in cells from nonasthmatics in contrast, cyclin D1 expression in asthmatics was resistant to inhibition by dexamethasone. This was independent of a repressive effect on glucocorticoid receptor translocation. Our results corroborate evidence demonstrating that corticosteroids inhibit mitogen-induced proliferation only in ASM cells from subjects without asthma and suggest that there are corticosteroid-insensitive proliferative pathways in asthmatics.

  7. Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1.

    Science.gov (United States)

    Quante, Timo; Ng, Yee Ching; Ramsay, Emma E; Henness, Sheridan; Allen, Jodi C; Parmentier, Johannes; Ge, Qi; Ammit, Alaina J

    2008-08-01

    The mechanisms by which corticosteroids reduce airway inflammation are not completely understood. Traditionally, corticosteroids were thought to inhibit cytokines exclusively at the transcriptional level. Our recent evidence, obtained in airway smooth muscle (ASM), no longer supports this view. We have found that corticosteroids do not act at the transcriptional level to reduce TNF-alpha-induced IL-6 gene expression. Rather, corticosteroids inhibit TNF-alpha-induced IL-6 secretion by reducing the stability of the IL-6 mRNA transcript. TNF-alpha-induced IL-6 mRNA decays at a significantly faster rate in ASM cells pretreated with the corticosteroid dexamethasone (t(1/2) = 2.4 h), compared to vehicle (t(1/2) = 9.0 h; P ASM cells.

  8. Practice affairs committee

    Directory of Open Access Journals (Sweden)

    Dan Sadowski

    2004-01-01

    Full Text Available The Practice Affairs Committee has had a productive year representing the interests of gastroenterologists involved in clinical care. The principle mandate of the committee is to address all issues relevant to the practice of gastroenterology, such as participation in the development of clinical practice guidelines and education programs, and the facilitation of clinical research. A major activity in 2003 was participation in the drafting of several new clinical practice guidelines: Infliximab and the management of Crohn's disease;Screening for colorectal cancer; andManagement of gastroesophageal reflux disease.

  9. 7 CFR 1260.104 - Committee.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Committee. 1260.104 Section 1260.104 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Promotion and Research Order Definitions § 1260.104 Committee. Committee means the Beef Promotion...

  10. ASM LabCap's contributions to disease surveillance and the International Health Regulations (2005).

    Science.gov (United States)

    Specter, Steven; Schuermann, Lily; Hakiruwizera, Celestin; Sow, Mah-Séré Keita

    2010-12-03

    The revised International Health Regulations [IHR(2005)], which requires the Member States of the World Health Organization (WHO) to develop core capacities to detect, assess, report, and respond to public health threats, is bringing new challenges for national and international surveillance systems. As more countries move toward implementation and/or strengthening of their infectious disease surveillance programs, the strengthening of clinical microbiology laboratories becomes increasingly important because they serve as the first line responders to detect new and emerging microbial threats, re-emerging infectious diseases, the spread of antibiotic resistance, and the possibility of bioterrorism. In fact, IHR(2005) Core Capacity #8, "Laboratory", requires that laboratory services be a part of every phase of alert and response.Public health laboratories in many resource-constrained countries require financial and technical assistance to build their capacity. In recognition of this, in 2006, the American Society for Microbiology (ASM) established an International Laboratory Capacity Building Program, LabCap, housed under the ASM International Board. ASM LabCap utilizes ASM's vast resources and its membership's expertise-40,000 microbiologists worldwide-to strengthen clinical and public health laboratory systems in low and low-middle income countries. ASM LabCap's program activities align with HR(2005) by building the capability of resource-constrained countries to develop quality-assured, laboratory-based information which is critical to disease surveillance and the rapid detection of disease outbreaks, whether they stem from natural, deliberate or accidental causes.ASM LabCap helps build laboratory capacity under a cooperative agreement with the U.S. Centers for Disease Control and Prevention (CDC) and under a sub-contract with the Program for Appropriate Technology in Health (PATH) funded by the United States Agency for International Development (USAID

  11. A Survey of Variable Extragalactic Sources with XTE's All Sky Monitor (ASM)

    Science.gov (United States)

    Jernigan, Garrett

    1998-01-01

    The original goal of the project was the near real-time detection of AGN utilizing the SSC 3 of the ASM on XTE which does a deep integration on one 100 square degree region of the sky. While the SSC never performed sufficiently well to allow the success of this goal, the work on the project has led to the development of a new analysis method for coded aperture systems which has now been applied to ASM data for mapping regions near clusters of galaxies such as the Perseus Cluster and the Coma Cluster. Publications are in preparation that describe both the new method and the results from mapping clusters of galaxies.

  12. 46 CFR 53.01-3 - Adoption of section IV of the ASME Boiler and Pressure Vessel Code.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of section IV of the ASME Boiler and Pressure...) MARINE ENGINEERING HEATING BOILERS General Requirements § 53.01-3 Adoption of section IV of the ASME Boiler and Pressure Vessel Code. (a) Heating boilers shall be designed, constructed, inspected,...

  13. 46 CFR 52.01-2 - Adoption of section I of the ASME Boiler and Pressure Vessel Code.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of section I of the ASME Boiler and Pressure...) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-2 Adoption of section I of the ASME Boiler and Pressure Vessel Code. (a) Main power boilers and auxiliary boilers shall be designed,...

  14. Plasma Science Committee (PLSC)

    Science.gov (United States)

    1990-12-01

    The Plasma Science Committee (PLSC) is a standing committee under the auspices of the Board on Physics and Astronomy, Commission on Physical Sciences, Mathematics, and Applications of the National Academy of Sciences - National Research Council. Plasma sciences represent a broad and diverse field. The PLSC has accepted the responsibility of monitoring the continuing development and assessing the general health of the field as whole. Although select advisory bodies have been created to address specific issues that affect plasma science, such as the Fusion Policy Advisory Committee (FPAC), the PLSC provides a focus for the plasma science community that is unique and essential. The membership of the PLSC is drawn from research laboratories in universities, industry, and government. Areas of expertise on the committee include accelerators and beams, space physics, astrophysics, computational physics and applied mathematics, fusion plasmas, fundamental experiments and theory, radiation sources, low temperature plasmas, and plasma-surface interactions. The PLSC is well prepared to respond to requests for studies on specific issues.

  15. Roles of the outer membrane protein AsmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells.

    Science.gov (United States)

    Prieto, Ana I; Hernández, Sara B; Cota, Ignacio; Pucciarelli, M Graciela; Orlov, Yuri; Ramos-Morales, Francisco; García-del Portillo, Francisco; Casadesús, Josep

    2009-06-01

    A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA gene. Disruption of asmA suppressed bile sensitivity also in phoP and wec mutants of S. enterica and increased the MIC of sodium deoxycholate for the parental strain ATCC 14028. Increased levels of marA mRNA were found in asmA, asmA dam, asmA phoP, and asmA wec strains of S. enterica, suggesting that lack of AsmA activates expression of the marRAB operon. Hence, asmA mutations may enhance bile resistance by inducing gene expression changes in the marRAB-controlled Mar regulon. In silico analysis of AsmA structure predicted the existence of one transmembrane domain. Biochemical analysis of subcellular fractions revealed that the asmA gene of S. enterica encodes a protein of approximately 70 kDa located in the outer membrane. Because AsmA is unrelated to known transport and/or efflux systems, we propose that activation of marRAB in asmA mutants may be a consequence of envelope reorganization. Competitive infection of BALB/c mice with asmA(+) and asmA isogenic strains indicated that lack of AsmA attenuates Salmonella virulence by the oral route but not by the intraperitoneal route. Furthermore, asmA mutants showed a reduced ability to invade epithelial cells in vitro.

  16. Simulation and optimization of a coking wastewater biological treatment process by activated sludge models (ASM).

    Science.gov (United States)

    Wu, Xiaohui; Yang, Yang; Wu, Gaoming; Mao, Juan; Zhou, Tao

    2016-01-01

    Applications of activated sludge models (ASM) in simulating industrial biological wastewater treatment plants (WWTPs) are still difficult due to refractory and complex components in influents as well as diversity in activated sludges. In this study, an ASM3 modeling study was conducted to simulate and optimize a practical coking wastewater treatment plant (CWTP). First, respirometric characterizations of the coking wastewater and CWTP biomasses were conducted to determine the specific kinetic and stoichiometric model parameters for the consecutive aeration-anoxic-aeration (O-A/O) biological process. All ASM3 parameters have been further estimated and calibrated, through cross validation by the model dynamic simulation procedure. Consequently, an ASM3 model was successfully established to accurately simulate the CWTP performances in removing COD and NH4-N. An optimized CWTP operation condition could be proposed reducing the operation cost from 6.2 to 5.5 €/m(3) wastewater. This study is expected to provide a useful reference for mathematic simulations of practical industrial WWTPs.

  17. Technical justification for ASME code section xi crack detection by visual examination

    Energy Technology Data Exchange (ETDEWEB)

    Nickell, R.E. [Applied Science and Technology, Poway, CA (United States); Rashid, Y.R. [ANATECH Corp., San Diego (United States)

    2001-07-01

    A critical technical element of nuclear power plant license renewal in the United States is the demonstration that the effects of aging do not compromise the intended safety function(s) of a system, structure, or component during the extended term of operation. The demonstration may take either of two forms. First, it can be shown that the design basis for the system, structure, or component is sufficiently robust that the aging effects have been insignificant through the current license term, and will continue to be insignificant through the extended term. Alternatively, it can be shown that, while the aging effects may be potentially significant, those effects can be managed and functionality maintained by defined programmatic activities during the extended term of operation. The first of the two approaches is generally provided by the construction basis, such as construction in accordance with the ASME Code Section III and other consensus codes and standards. The second of the two approaches is often provided by periodic inservice inspection and testing, in accordance with the ASME Code Section XI. The purpose of the ASME Section XI inspections and tests is to assure that systems, components, and structures are fit for continued service until the next scheduled inspection or test. The purpose of this paper is to document the effectiveness of the current ASME Code Section XI visual examination procedures in detecting the effects of aging for systems, structures, and components that are tolerant of mature cracks. (author)

  18. SDZ ASM 981 : an emerging safe and effective treatment for atopic dermatitis

    NARCIS (Netherlands)

    Luger, T; Van Leent, EJM; Graeber, M; Hedgecock, S; Thurston, M; Kandra, A; Berth-Jones, J; Bjerke, J; Christophers, E; Knulst, AC; Morren, M; Morris, A; Reitamo, S; Roed-Petersen, J; Schoepf, E; Thestrup-Pedersen, K; Van der Valk, PGM; Bos, JD

    2001-01-01

    Background SDZ ASM 981 is a selective inhibitor of the production of pro-inflammatory cytokines from T cells and mast cells in vitro. It is the first ascomycin macrolactam derivative under development for the treatment of inflammatory skin diseases. Objectives This study was: designed to determine t

  19. Welding of NPT-Stamped Vessel in Accordance with ASME Code%ASME规范NPT钢印取证容器的焊接

    Institute of Scientific and Technical Information of China (English)

    吴佳

    2014-01-01

    Based on ASME Boiler&Pressure Vessel Code, the paper explains how to conduct welding operation on NPT-Stamped vessels that are certificated in accordance with ASME code.%结合ASME规范,介绍ASME NPT钢印取证容器焊接过程。

  20. Late Cenozoic genus Fupingopollenites development and its implications for the Asian summer monsoon (ASM) evolution

    Science.gov (United States)

    Miao, Y.; Song, C.; Fang, X.; Meng, Q.; Zhang, P.; Wu, F.; Yan, X.

    2015-12-01

    An extinct palynomorph, Fupingopollenites, was used as the basis for a discussion of the late Cenozoic Asian summer monsoon (ASM) evolution and its possible driving forces. Based on the spatial and temporal variations in its percentages across Inner and East Asia, we found that Fupingopollenites mainly occurred in East Asia, with boundaries to the NE of ca. 42°N, 135°E and NW of ca. 36°N, 103°E during the Early Miocene (ca. 23-17 Ma). This region enlarged westwards, reaching the eastern Qaidam Basin (ca. 36°N, 97.5°E) during the Middle Miocene (ca. 17-11 Ma), before noticeably retreating to a region bounded to the NW at ca. 33°N, 105°E during ca. 11-5.3 Ma. The region then shrank further in the Pliocene, with the NE boundary shrinking southwards to about 35°N, 120°E; the area then almost disappeared during the Pleistocene (2.6-0 Ma). The flourishing and subsequent extinction of Fupingopollenites is indicative of a narrow ecological amplitude with a critical dependence on habitat humidity and temperature (most likely mean annual precipitation (MAP) >1000 mm and mean annual temperature (MAT) >10°C). Therefore, the Fupingopollenites geographic distribution can indicate the humid ASM evolution during the late Cenozoic, revealing that the strongest ASM period occurred during the Middle Miocene Climate Optimum (MMCO, ~17-14 Ma), after which the ASM weakened coincident with global cooling. We argue that the global cooling played a critical role in the ASM evolution, while the Tibetan Plateau uplifts made a relatively small contribution. This result was supported by a Miocene pollen record at the Qaidam Basin, inner Asia and the contemporaneously compiled pollen records across the Eurasia.

  1. Statistical analysis of geomagnetic field intensity differences between ASM and VFM instruments onboard Swarm constellation

    Science.gov (United States)

    De Michelis, Paola; Tozzi, Roberta; Consolini, Giuseppe

    2017-02-01

    From the very first measurements made by the magnetometers onboard Swarm satellites launched by European Space Agency (ESA) in late 2013, it emerged a discrepancy between scalar and vector measurements. An accurate analysis of this phenomenon brought to build an empirical model of the disturbance, highly correlated with the Sun incidence angle, and to correct vector data accordingly. The empirical model adopted by ESA results in a significant decrease in the amplitude of the disturbance affecting VFM measurements so greatly improving the vector magnetic data quality. This study is focused on the characterization of the difference between magnetic field intensity measured by the absolute scalar magnetometer (ASM) and that reconstructed using the vector field magnetometer (VFM) installed on Swarm constellation. Applying empirical mode decomposition method, we find the intrinsic mode functions (IMFs) associated with ASM-VFM total intensity differences obtained with data both uncorrected and corrected for the disturbance correlated with the Sun incidence angle. Surprisingly, no differences are found in the nature of the IMFs embedded in the analyzed signals, being these IMFs characterized by the same dominant periodicities before and after correction. The effect of correction manifests in the decrease in the energy associated with some IMFs contributing to corrected data. Some IMFs identified by analyzing the ASM-VFM intensity discrepancy are characterized by the same dominant periodicities of those obtained by analyzing the temperature fluctuations of the VFM electronic unit. Thus, the disturbance correlated with the Sun incidence angle could be still present in the corrected magnetic data. Furthermore, the ASM-VFM total intensity difference and the VFM electronic unit temperature display a maximal shared information with a time delay that depends on local time. Taken together, these findings may help to relate the features of the observed VFM-ASM total intensity

  2. 78 FR 64230 - DHS Data Privacy and Integrity Advisory Committee

    Science.gov (United States)

    2013-10-28

    ... participate in Committee activities and provide material input into Committee research and recommendations... Department ethics officials. DHS may not release these reports or the information in them to the public... Committee; however, while attending meetings or otherwise engaged in Committee business, members may...

  3. Anchoring contextual analysis in health policy and systems research: A narrative review of contextual factors influencing health committees in low and middle income countries.

    Science.gov (United States)

    George, Asha; Scott, Kerry; Garimella, Surekha; Mondal, Shinjini; Ved, Rajani; Sheikh, Kabir

    2015-05-01

    Health committees, councils or boards (HCs) mediate between communities and health services in many health systems. Despite their widespread prevalence, HC functions vary due to their diversity and complexity, not least because of their context specific nature. We undertook a narrative review to better understand the contextual features relevant to HCs, drawing from Scopus and the internet. We found 390 English language articles from journals and grey literature since 1996 on health committees, councils and boards. After screening with inclusion and exclusion criteria, we focused on 44 articles. Through an iterative process of exploring previous attempts at understanding context in health policy and systems research (HPSR) and the HC literature, we developed a conceptual framework that delineates these contextual factors into four overlapping spheres (community, health facilities, health administration, society) with cross-cutting issues (awareness, trust, benefits, resources, legal mandates, capacity-building, the role of political parties, non-governmental organizations, markets, media, social movements and inequalities). While many attempts at describing context in HPSR result in empty arenas, generic lists or amorphous detail, we suggest anchoring an understanding of context to a conceptual framework specific to the phenomena of interest. By doing so, our review distinguishes between contextual elements that are relatively well understood and those that are not. In addition, our review found that contextual elements are dynamic and porous in nature, influencing HCs but also being influenced by them due to the permeability of HCs. While reforms focus on tangible HC inputs and outputs (training, guidelines, number of meetings held), our review of contextual factors highlights the dynamic relationships and broader structural elements that facilitate and/or hinder the role of health committees in health systems. Such an understanding of context points to its

  4. Neurospora crassa ASM-1 complements the conidiation defect in a stuA mutant of Aspergillus nidulans.

    Science.gov (United States)

    Chung, Dawoon; Upadhyay, Srijana; Bomer, Brigitte; Wilkinson, Heather H; Ebbole, Daniel J; Shaw, Brian D

    2015-01-01

    Aspergillus nidulans StuA and Neurospora crassa ASM-1 are orthologous APSES (ASM-1, PHD1, SOK2, Efg1, StuA) transcription factors conserved across a diverse group of fungi. StuA and ASM-1 have roles in asexual (conidiation) and sexual (ascospore formation) development in both organisms. To address the hypothesis that the last common ancestor of these diverse fungi regulated conidiation with similar genes, asm-1 was introduced into the stuA1 mutant of A. nidulans. Expression of asm-1 complemented defective conidiophore morphology and restored conidia production to wild type levels in stuA1. Expression of asm-1 in the stuA1 strain did not rescue the defect in sexual development. When the conidiation regulator AbaA was tagged at its C-terminus with GFP in A. nidulans, it localized to nuclei in phialides. When expressed in the stuA1 mutant, AbaA::GFP localized to nuclei in conidiophores but no longer was confined to phialides, suggesting that expression of AbaA in specific cell types of the conidiophore was conditioned by StuA. Our data suggest that the function in conidiation of StuA and ASM-1 is conserved and support the view that, despite the great morphological and ontogenic diversity of their condiphores, the last common ancestor of A. nidulans and N. crassa produced an ortholog of StuA that was involved in conidiophore development.

  5. The risk-benefit task of research ethics committees: An evaluation of current approaches and the need to incorporate decision studies methods

    Directory of Open Access Journals (Sweden)

    Bernabe Rosemarie D L C

    2012-04-01

    Full Text Available Abstract Background Research ethics committees (RECs are tasked to assess the risks and the benefits of a trial. Currently, two procedure-level approaches are predominant, the Net Risk Test and the Component Analysis. Discussion By looking at decision studies, we see that both procedure-level approaches conflate the various risk-benefit tasks, i.e., risk-benefit assessment, risk-benefit evaluation, risk treatment, and decision making. This conflation makes the RECs’ risk-benefit task confusing, if not impossible. We further realize that RECs are not meant to do all the risk-benefit tasks; instead, RECs are meant to evaluate risks and benefits, appraise risk treatment suggestions, and make the final decision. Conclusion As such, research ethics would benefit from looking beyond the procedure-level approaches and allowing disciplines like decision studies to be involved in the discourse on RECs’ risk-benefit task.

  6. NIH oversight of human gene transfer research involving retroviral, lentiviral, and adeno-associated virus vectors and the role of the NIH recombinant DNA advisory committee.

    Science.gov (United States)

    O'Reilly, Marina; Shipp, Allan; Rosenthal, Eugene; Jambou, Robert; Shih, Tom; Montgomery, Maureen; Gargiulo, Linda; Patterson, Amy; Corrigan-Curay, Jacqueline

    2012-01-01

    In response to public and scientific concerns regarding human gene transfer research, the National Institutes of Health (NIH) developed a transparent oversight system that extends to human gene transfer protocols that are either conducted with NIH funding or conducted at institutions that receive NIH funding for recombinant DNA research. The NIH Recombinant DNA Advisory Committee (RAC) has been the primary advisory body to NIH regarding the conduct of this research. Human gene transfer research proposals that are subject to the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines) must be submitted to the NIH Office of Biotechnology Activities (OBA), and protocols that raise novel scientific, safety, medical, ethical, or social issues are publicly discussed at the RAC's quarterly public meetings. OBA also convenes gene transfer safety symposia and policy conferences to provide a public forum for scientific experts to discuss emerging issues in the field. This transparent system of review promotes the rapid exchange of important scientific information and dissemination of data. The goal is to optimize the conduct of individual research protocols and to advance gene transfer research generally. This process has fostered the development of retroviral, lentiviral, and adeno-associated viral vector mediated gene delivery.

  7. Sociocultural barriers to medical care among Mexican Americans in Texas: a summary report of research conducted by the Southwest Medical Sociology Ad Hoc Committee.

    Science.gov (United States)

    Quesada, G M; Heller, P L

    1977-05-01

    This paper summarizes research findings from members of the Southwest Medical Sociology Ad Hoc Committee concerning sociocultural barriers to medical care among Mexican Americans in Texas. Committee members individually, or in two-person groups, studied a number of factors concerning Mexican-American medical care in Texas such as: 1) mortality, morbidity, and other health status indicators; 2) health manpower and educational needs; 3) political factors impeding economical health care; 4) alienation, familism, and their relationship to utilization of the health services; 5) language and communication barriers; and 6) folk medicine. Findings include documentation that structural alienation of Mexican-Americans from mainstream Anglo-American middle-class society is carried over into their relation with utilization of the health care delivery system; that their emphasis on familism works alternatively to encourage and discourage their seeking access to health care; the language differences serve to perpetuate certain cultural differences that are inimical to health care delivery; and that curanderismo can be seen as complementing other types of health care. The report concludes with a number of recommendations for accomplishing cultural integration that will lead to better care for this segment of the health population.

  8. Report on task assignment No. 3 for the Waste Package Project; Parts A & B, ASME pressure vessel codes review for waste package application; Part C, Library search for reliability/failure rates data on low temperature low pressure piping, containers, and casks with long design lives

    Energy Technology Data Exchange (ETDEWEB)

    Trabia, M.B.; Kiley, M.; Cardle, J.; Joseph, M.

    1991-07-01

    The Waste Package Project Research Team, at UNLV, has four general required tasks. Task one is the management, quality assurance, and overview of the research that is performed under the cooperative agreement. Task two is the structural analysis of spent fuel and high level waste. Task three is an American Society of Mechanical Engineers (ASME) Pressure Vessel Code review for waste package application. Finally, task four is waste package labeling. This report includes preliminary information about task three (ASME Pressure Vessel Code review for Waste package Application). The first objective is to compile a list of the ASME Pressure Vessel Code that can be applied to waste package containers design and manufacturing processes. The second objective is to explore the use of these applicable codes to the preliminary waste package container designs. The final objective is to perform a library search for reliability and/or failure rates data on low pressure, low temperature, containers and casks with long design lives.

  9. 81 FR 54586 - Agenda and Notice of Public Meetings of the Moving To Work Research Advisory Committee

    Science.gov (United States)

    2016-08-16

    ...-day meeting to discuss the framework and associated research methodologies for potential policies that... research methodology discussion b. Discuss framework and possible research methodologies for each policy c... Comment VII. BREAK VIII. Policy Framework and Research Methodologies--MTW Statutory Objective #1:...

  10. Executive committee

    Science.gov (United States)

    Xiao, Guoqing; Cai, Xiaohong; Ding, Dajun; Ma, Xinwen; Zhao, Yongtao

    2014-04-01

    ChairVice Chair Toshiyuki AzumaRoberto Rivarola Atomic, Molecular & Optical Physics LabUniversidad Nacional de Rosario and Advanced Science InstituteInstituto de Fisica Rosario RIKEN, JapanRosario, Argentina SecretaryMembers Dominique VernhetJoachim Burgdörfer, Austria Institut des NanoSciences de Paris Birgit Lohmann, Australia Université Pierre et Marie Curie Hossein Sadeghpour, USA Paris, FranceThomas Stöhlker, Germany Past ChairJim McCann, UK Barry DunningGuoqing Xiao, China Physics & AstronomyXiaohong Cai, China Rice University, HoustonXinwen Ma, China Texas, USAYongtao Zhao, China TreasurerFernando Martin, Spain Henrik CederquistLuis Mendez, Spain Alba Nova University CenterAnatoli Kheifets, Australia Stockholm University Stockholm, Sweden Details of the general committee are available in the PDF

  11. Conference Committees

    Science.gov (United States)

    2015-11-01

    Scientific Committee Silvia Arrese-Igor Irigoyen (CFM, CSIC - UPV/EHU, Donostia), Javier Campo (ICMA-CSIC, Zaragoza), Carlos Frontera (ICMAB-CSIC, Barcelona), Victoria García Sakai (ISIS, Chilton), Cristina Gómez-Polo (UPNa, Pamplona), Miguel Ángel González (ILL, Grenoble), Pedro Gorría (Universidad Oviedo), Jon Gutiérrez Echevarría (EHU/UPV, Bilbao), J. Iñaki Pérez Landazábal (UPNa, Pamplona), Vicente Recarte (UPNa, Pamplona), Jesús Ruíz Hervías (UPM, Madrid), Vicente Sánchez-Alarcos (UPNa, Pamplona), Antonio Urbina (UPC, Cartagena) Organizing Committee J. Iñaki Pérez Landazábal (Co-Chair), Vicente Recarte ( Co-Chair), Cristina Gómez-Polo, Silvia Larumbe Abuin, Vicente Sánchez-Alarcos Editors of the Proceedings J. Iñaki Pérez Landazábal, Vicente Recarte Plenary speakers Charles Simon (Institut Laue-Langevin, Grenoble, France), Miguel Angel Alario Franco (Universidad Complutense, Madrid, Spain), Dieter Richter (Jülich Centre for Neutron Science, Jülich, Germany), James Yeck (European Spallation Source, Lund, Sweden) Invited speakers Manu Barandiarán (BCMaterials & EHU/UPV), Arantxa Arbe (MFC, CSIC- UPV/EHU), José Luis Martínez (Consorcio ESS-Bilbao), Marta Castellote, IETcc-CSIC), Josep Lluis Tamarit (UPC), Diego Alba-Venero (ISIS), Elizabeth Castillo (CIC Energigune), Josu M. Igartua (EHU/UPV), Antonio Dos Santos (UPM), Alex Masalles (Museu Nacional d'Art de Catalunya), José Abad (UPCT), Claudia Mondelli (ILL), Oscar Fabelo (ILL), Aurora Nogales (IEM-CSIC), Jesús Rodríguez (UC), Gerardo

  12. ASME AG-1 Section FC Qualified HEPA Filters; a Particle Loading Comparison - 13435

    Energy Technology Data Exchange (ETDEWEB)

    Stillo, Andrew [Camfil Farr, 1 North Corporate Drive, Riverdale, NJ 07457 (United States); Ricketts, Craig I. [New Mexico State University, Department of Engineering Technology and Surveying Engineering, P.O. Box 30001 MSC 3566, Las Cruces, NM 88003-8001 (United States)

    2013-07-01

    High Efficiency Particulate Air (HEPA) Filters used to protect personnel, the public and the environment from airborne radioactive materials are designed, manufactured and qualified in accordance with ASME AG-1 Code section FC (HEPA Filters) [1]. The qualification process requires that filters manufactured in accordance with this ASME AG-1 code section must meet several performance requirements. These requirements include performance specifications for resistance to airflow, aerosol penetration, resistance to rough handling, resistance to pressure (includes high humidity and water droplet exposure), resistance to heated air, spot flame resistance and a visual/dimensional inspection. None of these requirements evaluate the particle loading capacity of a HEPA filter design. Concerns, over the particle loading capacity, of the different designs included within the ASME AG-1 section FC code[1], have been voiced in the recent past. Additionally, the ability of a filter to maintain its integrity, if subjected to severe operating conditions such as elevated relative humidity, fog conditions or elevated temperature, after loading in use over long service intervals is also a major concern. Although currently qualified HEPA filter media are likely to have similar loading characteristics when evaluated independently, filter pleat geometry can have a significant impact on the in-situ particle loading capacity of filter packs. Aerosol particle characteristics, such as size and composition, may also have a significant impact on filter loading capacity. Test results comparing filter loading capacities for three different aerosol particles and three different filter pack configurations are reviewed. The information presented represents an empirical performance comparison among the filter designs tested. The results may serve as a basis for further discussion toward the possible development of a particle loading test to be included in the qualification requirements of ASME AG-1

  13. ASME B16.34-2004标准核心内容

    Institute of Scientific and Technical Information of China (English)

    韩肇俊

    2007-01-01

    在美国的国家标准中,编号为B16的系列标准是由ASME B16委员会负责编制、与ASME锅炉及压力容器规范配套使用的”管道组成件标准(Piping component standards)”。

  14. Appropriate nominal stresses for use with ASME Code pressure-loading stress indices for nozzles

    Energy Technology Data Exchange (ETDEWEB)

    Rodabaugh, E.C.

    1976-06-01

    This program is part of a cooperative effort with industry to develop and verify analytical methods for assessing the safety of nuclear pressure-vessel and piping-system design. The study of nominal stresses and stress indices described is part of a continuing study of design rules for nozzles in pressure vessels being coordinated by the PVRC Subcommittee on Reinforced Openings and External Loadings. Results from these studies are used by appropriate ASME Code groups in drafting new and improved design rules.

  15. The Investment Committee. AGB Effective Committee Series

    Science.gov (United States)

    Yoder, Jay A.

    2011-01-01

    This publication is part of an AGB series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices included in this text support the objectives of board committees:…

  16. 基于ASME SECTION I的集箱旋压封头强度计算

    Institute of Scientific and Technical Information of China (English)

    夏国泉

    2010-01-01

    根据集箱旋压封头的结构特点,研究了ASME SECTION I与GB/T9222-2008适用的强度计算规定,分析了ASME SECTION I与GB/T9222-2008在集箱热旋压收口封头设计方面的异同。

  17. Comparison of SKIFS 2004:1 and Tillsynshandbok PSA against the ASME PRA Standard and European requirements on PSA; Jaemfoerelse av SKIFS 2004:1 och Tillsynshandbok PSA mot ASME PRA Standard och Europeiska krav paa PSA

    Energy Technology Data Exchange (ETDEWEB)

    Hellstroem, Per

    2005-04-15

    Requirements on PSA for risk informed applications are expressed in different international documents. The ASME PRA standard published in spring 2002 is one such document, PSA requirements are also expressed in the European Utility Requirements (EUR) for new reactors. The Swedish PSA requirements are provided in the Swedish regulators (SKI) statutes SKIFS 2004:1. SKI also has a review handbook for PSA activities (SKI report 2003:48). The review handbook is a support during review of the utilities PSA activities and the PSAs themselves. The review handbook expresses SKIs expectations by providing so called important aspects for both the PSA work and the PSAs, A comparison of SKIFS requirements and the important aspects in the Review handbook, on one side, and the requirements on PSA in EUR and ASME on the other side, is presented. The comparison shows a large difference in the level of detail in the different documents, where ASME is most detailed and specific. This is expected since the SKI review handbook not is a 'PSA guide' in the same way as the ASME PRA standard. A direct comparison of the ASME PRA standard requirements with the important aspects in the review handbook cannot answer the question which ASME capacity level that is achieved by a PSA meeting all important aspects. The conclusion is that it is not likely to achieve capacity level 2 and 3, since very few ASME level 3 attributes are explicitly expressed as important aspects, though many are expressed in general terms. The review handbook important aspects that are most similar to the ASME capacity level 1 attributes are initiating events, sequence analysis, and system analysis while less similarity is found for analysis of operator actions data analysis, quantification and containment analysis (level 2). Less similarity is found for capacity level 2 and 3. However, the number of additional ASME attributes on capacity level 2 and 3 are few. There are also important aspects in the review

  18. GC-ASM: Synergistic Integration of Graph-Cut and Active Shape Model Strategies for Medical Image Segmentation.

    Science.gov (United States)

    Chen, Xinjian; Udupa, Jayaram K; Alavi, Abass; Torigian, Drew A

    2013-05-01

    Image segmentation methods may be classified into two categories: purely image based and model based. Each of these two classes has its own advantages and disadvantages. In this paper, we propose a novel synergistic combination of the image based graph-cut (GC) method with the model based ASM method to arrive at the GC-ASM method for medical image segmentation. A multi-object GC cost function is proposed which effectively integrates the ASM shape information into the GC framework. The proposed method consists of two phases: model building and segmentation. In the model building phase, the ASM model is built and the parameters of the GC are estimated. The segmentation phase consists of two main steps: initialization (recognition) and delineation. For initialization, an automatic method is proposed which estimates the pose (translation, orientation, and scale) of the model, and obtains a rough segmentation result which also provides the shape information for the GC method. For delineation, an iterative GC-ASM algorithm is proposed which performs finer delineation based on the initialization results. The proposed methods are implemented to operate on 2D images and evaluated on clinical chest CT, abdominal CT, and foot MRI data sets. The results show the following: (a) An overall delineation accuracy of TPVF > 96%, FPVF segmentation step compared to GC which requires seed specification and improves on the accuracy of GC. (e) One disadvantage of GC-ASM is its increased computational expense owing to the iterative nature of the algorithm.

  19. 76 FR 45578 - Request for Nominations for Members on a Public Advisory Committee; Medical Imaging Drugs...

    Science.gov (United States)

    2011-07-29

    ... Committee; Medical Imaging Drugs Advisory Committee AGENCY: Food and Drug Administration, HHS. ACTION... on the Medical Imaging Drugs Advisory Committee in the Center for Drug Evaluation and Research. FDA... requesting nominations for voting members on the Medical Imaging Drugs Advisory Committee (the Committee...

  20. 76 FR 39404 - Cardiovascular and Renal Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-07-06

    ... HUMAN SERVICES Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee; Notice of... to the public. Name of Committee: Cardiovascular and Renal Drugs Advisory Committee. General Function... application (NDA) 202439, rivaroxaban tablets, submitted by Johnson & Johnson Pharmaceutical Research...

  1. Understanding the Long-Term Spectral Variability of Cygnus X-1 from BATSE and ASM Observations

    Science.gov (United States)

    Zdziarski, Andrzej A.; Poutanen, Juri; Paciesas, William S.; Wen, Linqing; Six, N. Frank (Technical Monitor)

    2002-01-01

    We present a spectral analysis of observations of Cygnus X-1 by the RXTE/ASM (1.5-12 keV) and CGRO/BATSE (20-300 keV), including about 1200 days of simultaneous data. We find a number of correlations between intensities and hardnesses in different energy bands from 1.5 keV to 300 keV. In the hard (low) spectral state, there is a negative correlation between the ASM 1.5-12 keV flux and the hardness at any energy. In the soft (high) spectral state, the ASM flux is positively correlated with the ASM hardness (as previously reported) but uncorrelated with the BATSE hardness. In both spectral states, the BATSE hardness correlates with the flux above 100 keV, while it shows no correlation with the flux in the 20-100 keV range. At the same time, there is clear correlation between the BATSE fluxes below and above 100 keV. In the hard state, most of the variability can be explained by softening the overall spectrum with a pivot at approximately 50 keV. The observations show that there has to be another, independent variability pattern of lower amplitude where the spectral shape does not change when the luminosity changes. In the soft state, the variability is mostly caused by a variable hard (Comptonized) spectral component of a constant shape superimposed on a constant soft blackbody component. These variability patterns are in agreement with the dependence of the rms variability on the photon energy in the two states. We interpret the observed correlations in terms of theoretical Comptonization models. In the hard state, the variability appears to be driven mostly by changing flux in seed photons Comptonized in a hot thermal plasma cloud with an approximately constant power supply. In the soft state, the variability is consistent with flares of hybrid, thermal/nonthermal, plasma with variable power above a stable cold disk. Also, based on broadband pointed observations simultaneous with those of the ASM and BATSE, we find the intrinsic bolometric luminosity increases by a

  2. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.

    Science.gov (United States)

    Kim, Yongsoon; Sun, Hong

    2012-01-01

    In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor signaling (IIS) pathway regulates longevity, metabolism, reproduction and development. In mammals, acid sphingomyelinase (ASM) is an enzyme that hydrolyzes sphingomyelin to produce ceramide. ASM has been implicated in CD95 death receptor signaling under certain stress conditions. However, the involvement of ASM in growth factor receptor signaling under physiological conditions is not known. Here, we report that in vivo ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans. We have shown that inactivation of asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process. A significant cooperative effect on lifespan is observed between asm-3 deficiency and loss-of-function alleles of the age-1/PI 3-kinase, with the asm-3; age-1 double mutant animals having a mean lifespan 259% greater than that of the wild-type animals. The lifespan extension phenotypes caused by the loss of asm-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN. We have demonstrated that inactivation of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targeting genes of DAF-16. Together, our findings reveal a novel role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway. Importantly, we have found that two drugs known to inhibit mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type animals, in a manner similar to that achieved by genetic inactivation of the asm genes. Our studies illustrate a novel strategy of anti-aging by targeting ASM, which may potentially be extended to mammals.

  3. The Battlefield Health and Trauma Research Institute Scientific Ethics Committee: An Evolving Model for Fostering a Culture of Integrity

    Science.gov (United States)

    2012-01-01

    grants and contracts.8 The ORI defines research misconduct as ‘‘fabrication, falsification, or plagiarism in proposing, performing, or reviewing research...fabrication, falsification, or plagiarism (FFP) is only 1% to 2%, based on self-reporting.10,11 However, approx- imately 33% of scientists admitted...provide investigators training and guidance? THE ACADEMIC MODEL Just as regulations governing the ethical use of human and animal research subjects grew

  4. 78 FR 38351 - Blood Products Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-06-26

    ... HUMAN SERVICES Food and Drug Administration Blood Products Advisory Committee; Notice of Meeting AGENCY... will be closed to the public. Name of Committee: Blood Products Advisory Committee. General Function of..., Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA. FDA intends...

  5. 7 CFR 1260.167 - Powers of the Committee.

    Science.gov (United States)

    2010-01-01

    ... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Beef Promotion Operating Committee § 1260.167 Powers of the Committee. The... rules for the conduct of its business as it may deem advisable; (c) To establish committees of...

  6. 76 FR 42112 - Specialty Crop Committee Stakeholder Listening Sessions

    Science.gov (United States)

    2011-07-18

    ...; ] DEPARTMENT OF AGRICULTURE Office of the Secretary Specialty Crop Committee Stakeholder Listening Sessions AGENCY: Research, Education, and Economics, USDA. ACTION: Notice of stakeholder listening sessions... Department of Agriculture announces two stakeholder listening sessions of the Specialty Crop Committee,...

  7. 76 FR 62050 - DOE/NSF Nuclear Science Advisory Committee

    Science.gov (United States)

    2011-10-06

    ... (National Science Foundation), on scientific priorities within the field of basic nuclear science research... consultation with the Committee Management Secretariat, General Services Administration, notice is hereby given..., Committee Management Officer. BILLING CODE 6450-01-P ...

  8. 78 FR 62609 - DOE/NSF Nuclear Science Advisory Committee

    Science.gov (United States)

    2013-10-22

    ... within the field of basic nuclear science research. Additionally, the renewal of the DOE/NSF Nuclear... consultation with the Committee Management Secretariat, General Services Administration, notice is hereby given.... Matthews, Committee Management Officer. BILLING CODE 6450-01-P ...

  9. 78 FR 59381 - Advisory Committee for Engineering; Notice of Meeting

    Science.gov (United States)

    2013-09-26

    ... from the Office of the Director Industrial Innovation and Partnerships Overview Industrial Innovation and Partnerships Committee of Visitors Report Service Innovation Advisory Committee Member Topics... Director Discussion on Bilateral Collaborations 2-DARE (Emerging Frontiers in Research and Innovation...

  10. Alzheimer disease ethics--informed consent and related issues in clinical trials: results of a survey among the members of the Research Ethics Committees in Sweden.

    Science.gov (United States)

    Peterson, Gunbrith; Wallin, Anders

    2003-06-01

    The rapid advances in biomedical sciences have induced special moral and ethical attitudes, which ought to be taken into account. One of the most essential issues is the principles for participation in research of subjects with reduced decision-making capacity. We conducted a questionnaire survey among members of the research ethics committees in Sweden to find out their attitudes to a range of ethical issues related to research on subjects with Alzheimer's disease. One hundred thirty-six of those approached responded (66%), and 117 of the responses (56%) were considered substantially complete. There were 16 questions with fixed reply alternatives. Some central questions concerned the informed consent process. With a few exceptions, there were no significant differences in attitudes between the experts and laypersons, between persons of different ages, and between men and women. However, women and laypersons were in general keener to preserve the patient's integrity and the experts were more willing than the laypersons to allow participation of subjects with dementia in placebo-controlled trials.

  11. Study on Measurement of Kinetic Parameters in ASM-CN Model%ASM-CN模型中主要动力学参数的测定研究

    Institute of Scientific and Technical Information of China (English)

    刘芳; 陈季华; 顾国维

    2005-01-01

    灵敏度分析表明,ASM-CN模型中的异养菌衰减系数(bH)、异养菌最大比增长速率(μmH)和自养菌最大比增长速率(μmA)对活性污泥系统的性能有显著影响,着重研究了这3个参数.试验结果表明,在20℃时bH的平均值为0.48d-1,μmH的平均值为5.7 d-1,μmA的平均值为0.449 d-1.此外,还对这3个参数测定过程中的影响因素进行了分析.

  12. 管道剩余强度评价标准ASME B31G-2009的应用及优化改进

    Institute of Scientific and Technical Information of China (English)

    高富超

    2014-01-01

    管道是我国天然气、原油、成品油等能源输送的重要方式,随着国家多条战略能源管道服役年限的增长,腐蚀成为威胁管道安全运行的较大因素.目前我国在役输油气管道体积型腐蚀缺陷评价多采用ASME B31G标准.ASME B31G标准几经修改形成目前的ASME B31G-2009版本,本文通过比较ASME B31G-1984、ASME B31G-2009评定方法的不同,分析得出ASME B31G-2009的优化方法及结论.

  13. Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma.

    Science.gov (United States)

    Assayag, Evelyne Israël; Beaulieu, Marie-Josée; Cormier, Yvon

    2014-01-01

    Conventional asthma and COPD treatments include the use of bronchodilators, mainly β2-adrenergic agonists, muscarinic receptor antagonists and corticosteroids or leukotriene antagonists as anti-inflammatory agents. These active drugs are administered either separately or given as a fixed-dose combination medication into a single inhaler. ASM-024, a homopiperazinium compound, derived from the structural modification of diphenylmethylpiperazinium (DMPP), has been developed to offer an alternative mechanism of action that could provide symptomatic control through combined anti-inflammatory and bronchodilator properties in a single entity. A dose-dependent inhibition of cellular inflammation in bronchoalveolar lavage fluid was observed in ovalbumin-sensitized mice, subsequently treated for 3 days by nose-only exposure with aerosolized ASM-024 at doses up to 3.8 mg/kg (ED50 = 0.03 mg/kg). The methacholine ED250 values indicated that airway hyperresponsivenness (AHR) to methacholine decreased following ASM-024 administration by inhalation at a dose of 1.5 mg/kg, with a value of 0.145 ± 0.032 mg/kg for ASM 024-treated group as compared to 0.088 ± 0.023 mg/kg for untreated mice. In in vitro isometric studies, ASM-024 elicited dose-dependent relaxation of isolated mouse tracheal, human, and dog bronchial preparations contracted with methacholine and guinea pig tracheas contracted with histamine. ASM-024 showed also a dose and time dependant protective effect on methacholine-induced contraction. Overall, with its combined anti-inflammatory, bronchodilating and bronchoprotective properties, ASM-024 may represent a new class of drugs with a novel pharmacological approach that could prove useful for the chronic maintenance treatment of asthma and, possibly, COPD.

  14. Bronchodilatory and Anti-Inflammatory Effects of ASM-024, a Nicotinic Receptor Ligand, Developed for the Treatment of Asthma

    Science.gov (United States)

    Assayag, Evelyne Israël; Beaulieu, Marie-Josée; Cormier, Yvon

    2014-01-01

    Conventional asthma and COPD treatments include the use of bronchodilators, mainly β2-adrenergic agonists, muscarinic receptor antagonists and corticosteroids or leukotriene antagonists as anti-inflammatory agents. These active drugs are administered either separately or given as a fixed-dose combination medication into a single inhaler. ASM-024, a homopiperazinium compound, derived from the structural modification of diphenylmethylpiperazinium (DMPP), has been developed to offer an alternative mechanism of action that could provide symptomatic control through combined anti-inflammatory and bronchodilator properties in a single entity. A dose-dependent inhibition of cellular inflammation in bronchoalveolar lavage fluid was observed in ovalbumin-sensitized mice, subsequently treated for 3 days by nose-only exposure with aerosolized ASM-024 at doses up to 3.8 mg/kg (ED50 = 0.03 mg/kg). The methacholine ED250 values indicated that airway hyperresponsivenness (AHR) to methacholine decreased following ASM-024 administration by inhalation at a dose of 1.5 mg/kg, with a value of 0.145±0.032 mg/kg for ASM 024-treated group as compared to 0.088±0.023 mg/kg for untreated mice. In in vitro isometric studies, ASM-024 elicited dose-dependent relaxation of isolated mouse tracheal, human, and dog bronchial preparations contracted with methacholine and guinea pig tracheas contracted with histamine. ASM-024 showed also a dose and time dependant protective effect on methacholine-induced contraction. Overall, with its combined anti-inflammatory, bronchodilating and bronchoprotective properties, ASM-024 may represent a new class of drugs with a novel pharmacological approach that could prove useful for the chronic maintenance treatment of asthma and, possibly, COPD. PMID:24465890

  15. Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma.

    Directory of Open Access Journals (Sweden)

    Evelyne Israël Assayag

    Full Text Available Conventional asthma and COPD treatments include the use of bronchodilators, mainly β2-adrenergic agonists, muscarinic receptor antagonists and corticosteroids or leukotriene antagonists as anti-inflammatory agents. These active drugs are administered either separately or given as a fixed-dose combination medication into a single inhaler. ASM-024, a homopiperazinium compound, derived from the structural modification of diphenylmethylpiperazinium (DMPP, has been developed to offer an alternative mechanism of action that could provide symptomatic control through combined anti-inflammatory and bronchodilator properties in a single entity. A dose-dependent inhibition of cellular inflammation in bronchoalveolar lavage fluid was observed in ovalbumin-sensitized mice, subsequently treated for 3 days by nose-only exposure with aerosolized ASM-024 at doses up to 3.8 mg/kg (ED50 = 0.03 mg/kg. The methacholine ED250 values indicated that airway hyperresponsivenness (AHR to methacholine decreased following ASM-024 administration by inhalation at a dose of 1.5 mg/kg, with a value of 0.145 ± 0.032 mg/kg for ASM 024-treated group as compared to 0.088 ± 0.023 mg/kg for untreated mice. In in vitro isometric studies, ASM-024 elicited dose-dependent relaxation of isolated mouse tracheal, human, and dog bronchial preparations contracted with methacholine and guinea pig tracheas contracted with histamine. ASM-024 showed also a dose and time dependant protective effect on methacholine-induced contraction. Overall, with its combined anti-inflammatory, bronchodilating and bronchoprotective properties, ASM-024 may represent a new class of drugs with a novel pharmacological approach that could prove useful for the chronic maintenance treatment of asthma and, possibly, COPD.

  16. Method,Measure,and Immunity of the ASME Standard for Anti-brittle Fracture Thoughts,Methods and Absolution Steps of ASME Code for Anti-Brittle Fracture%ASME标准防脆断的思路、措施和豁免判定步骤

    Institute of Scientific and Technical Information of China (English)

    程涛涛; 黄明松

    2015-01-01

    介绍ASME 标准中防止低温脆断的总体思路和措施,并对该措施进行分析,比较了ASME Ⅷ-Ⅰ和ASME Ⅷ-Ⅱ中对防低温脆断措施方面的主要区别,列出了ASME材料低温冲击试验豁免判定的具体操作步骤。%This paper introduces the general idea and measures of preventing the low temperature brittle frac-ture in ASME standard,and analyzes the measures;it contrasts the main differences between ASME Ⅷ-Ⅰand ASME Ⅷ-Ⅱin preventing the low temperature brittle fracture;it lists the specific steps of impact test exemption of ASME.

  17. 76 FR 28209 - Committee on Regulation

    Science.gov (United States)

    2011-05-16

    ... Administrative Process'' and receive input from the committee on the planned research for the project. Complete..., at 2:30 p.m. ADDRESSES: The meeting will be held at the Administrative Conference of the United...; ] ADMINISTRATIVE CONFERENCE OF THE UNITED STATES Committee on Regulation ACTION: Notice of Public Meeting. SUMMARY...

  18. Fusion Policy Advisory Committee (FPAC)

    Energy Technology Data Exchange (ETDEWEB)

    1990-09-01

    This document is the final report of the Fusion Policy Advisory Committee. The report conveys the Committee's views on the matters specified by the Secretary in his charge and subsequent letters to the Committee, and also satisfies the provisions of Section 7 of the Magnetic Fusion Energy Engineering Act of 1980, Public Law 96-386, which require a triennial review of the conduct of the national Magnetic Fusion Energy program. Three sub-Committee's were established to address the large number of topics associated with fusion research and development. One considered magnetic fusion energy, a second considered inertial fusion energy, and the third considered issues common to both. For many reasons, the promise of nuclear fusion as a safe, environmentally benign, and affordable source of energy is bright. At the present state of knowledge, however, it is uncertain that this promise will become reality. Only a vigorous, well planned and well executed program of research and development will yield the needed information. The Committee recommends that the US commit to a plan that will resolve this critically important issue. It also outlines the first steps in a development process that will lead to a fusion Demonstration Power Plant by 2025. The recommended program is aggressive, but we believe the goal is reasonable and attainable. International collaboration at a significant level is an important element in the plan.

  19. Report from IPNS research plan committee on particle and nuclear physics studies at JHF 50-GeV proton synchrotron

    CERN Document Server

    Enyo, H; Okada, Y

    2003-01-01

    This report summarizes the evaluations and suggestions of IPNS research programs for JHF 50-GeV proton synchrotron. The following subjects are described: the role of JHF for particle and nuclear physics, neutrino oscillation experiment, physics of rare decay K(+) and high intense muon sources, strangeness nuclear physics, experiments of hadron physics and antiproton science experiments. (J.P.N.)

  20. Basic research needs to assure a secure energy future. A report from the Basic Energy Sciences Advisory Committee

    Energy Technology Data Exchange (ETDEWEB)

    None

    2003-02-01

    This report has highlighted many of the possible fundamental research areas that will help our country avoid a future energy crisis. The report may not have adequately captured the atmosphere of concern that permeated the discussions at the workshop. The difficulties facing our nation and the world in meeting our energy needs over the next several decades are very challenging. It was generally felt that traditional solutions and approaches will not solve the total energy problem. Knowledge that does not exist must be obtained to address both the quantity of energy needed to increase the standard of living world-wide and the quality of energy generation needed to preserve the environment. In terms of investments, it was clear that there is no single research area that will secure the future energy supply. A diverse range of economic energy sources will be required--and a broad range of fundamental research is needed to enable these. Many of the issues fall into the traditional materials and chemical sciences research areas, but with specific emphasis on understanding mechanisms, energy related phenomena, and pursuing novel directions in, for example, nanoscience and integrated modeling. An important result from the discussions, which is hopefully apparent from the brief presentations above, is that the problems that must be dealt with are truly multidisciplinary. This means that they require the participation of investigators with different skill sets. Basic science skills have to be complemented by awareness of the overall nature of the problem in a national and world context, and with knowledge of the engineering, design, and control issues in any eventual solution. It is necessary to find ways in which this can be done while still preserving the ability to do first-class basic science. The traditional structure of research, with specific disciplinary groupings, will not be sufficient. This presents great challenges and opportunities for the funders of the

  1. Analysis of systematic errors of the ASM/RXTE monitor and GT-48 γ-ray telescope

    Science.gov (United States)

    Fidelis, V. V.

    2011-06-01

    The observational data concerning variations of light curves of supernovae remnants—the Crab Nebula, Cassiopeia A, Tycho Brahe, and pulsar Vela—over 14 days scale that may be attributed to systematic errors of the ASM/RXTE monitor are presented. The experimental systematic errors of the GT-48 γ-ray telescope in the mono mode of operation were also determined. For this the observational data of TeV J2032 + 4130 (Cyg γ-2, according to the Crimean version) were used and the stationary nature of its γ-ray emission was confirmed by long-term observations performed with HEGRA and MAGIC. The results of research allow us to draw the following conclusions: (1) light curves of supernovae remnants averaged for long observing periods have false statistically significant flux variations, (2) the level of systematic errors is proportional to the registered flux and decreases with increasing temporal scale of averaging, (3) the light curves of sources may be modulated by the year period, and (4) the systematic errors of the GT-48 γ-ray telescope, in the amount caused by observations in the mono mode and data processing with the stereo-algorithm come to 0.12 min-1.

  2. Elastic-plastic analysis of the PVRC burst disk tests with comparison to the ASME code -- Primary stress limits

    Energy Technology Data Exchange (ETDEWEB)

    Jones, D.P.; Holliday, J.E.

    1999-02-01

    This paper provides a comparison between finite element analysis results and test data from the Pressure Vessel Research Council (PVRC) burst disk program. Testing sponsored by the PVRC over 20 years ago was done by pressurizing circular flat disks made from three different materials until failure by bursting. The purpose of this re-analysis is to investigate the use of finite element analysis (FEA) to assess the primary stress limits of the ASME Boiler and Pressure Vessel Code (1998) and to qualify the use of elastic-plastic (EP-FEA) for limit load calculations. The three materials tested represent the range of strength and ductility found in modern pressure vessel construction and include a low strength high ductility material, a medium strength medium ductility material, and a high strength low ductility low alloy material. Results of elastic and EP-FEA are compared to test data. Stresses from the elastic analyses are linearized for comparison of Code primary stress limits to test results. Elastic-plastic analyses are done using both best-estimate and elastic-perfectly plastic (EPP) stress-strain curves. Both large strain-large displacement (LSLD) and small strain-small displacement (SSSD) assumptions are used with the EP-FEA. Analysis results are compared to test results to evaluate the various analysis methods, models, and assumptions as applied to the bursting of thin disks.

  3. Robust boundary detection of left ventricles on ultrasound images using ASM-level set method.

    Science.gov (United States)

    Zhang, Yaonan; Gao, Yuan; Li, Hong; Teng, Yueyang; Kang, Yan

    2015-01-01

    Level set method has been widely used in medical image analysis, but it has difficulties when being used in the segmentation of left ventricular (LV) boundaries on echocardiography images because the boundaries are not very distinguish, and the signal-to-noise ratio of echocardiography images is not very high. In this paper, we introduce the Active Shape Model (ASM) into the traditional level set method to enforce shape constraints. It improves the accuracy of boundary detection and makes the evolution more efficient. The experiments conducted on the real cardiac ultrasound image sequences show a positive and promising result.

  4. Batse/Sax and Batse/RXTE-ASM Joint Spectral Studies of GRBs

    Science.gov (United States)

    Paciesas, William S.

    2002-01-01

    We proposed to make joint spectral analysis of gamma-ray bursts (GRBs) in the BATSE data base that are located within the fields of view of either the BeppoSAX wide field cameras (WFCs) or the RXTE all-sky monitor (ASM). The very broad-band coverage obtained in this way would facilitate various studies of GRB spectra that are difficult to perform with BATSE data alone. Unfortunately, the termination of the CGRO mission in June 2000 was not anticipated at the time of the proposal, and the sample of common events turned out to be smaller than we would have liked.

  5. ASME N510 test results for Savannah River Site AACS filter compartments

    Energy Technology Data Exchange (ETDEWEB)

    Paul, J.D.; Punch, T.M. [Westinghouse Savannah River Company, Aiken, SC (United States)

    1995-02-01

    The K-Reactor at the Savannah River Site recently implemented design improvements for the Airborne Activity Confinement System (AACS) by procuring, installing, and testing new Air Cleaning Units, or filter compartments, to ASME AG-11, N509, and N510 requirements. Specifically, these new units provide documentable seismic resistance to a Design Basis Accident earthquake, provide 2 inch adsorber beds with 0.25 second residence time, and meet all AG-1, N509, and N510 requirements for testability and maintainability. This paper presents the results of the Site acceptance testing and discusses an issue associated with sample manifold qualification testing.

  6. Draft ASME code case on ductile cast iron for transport packaging

    Energy Technology Data Exchange (ETDEWEB)

    Saegusa, T. [Central Research Inst. of Electric Power Industry, Abiko (Japan); Arai, T. [Central Research Inst. of Electric Power Industry, Yokosuka (Japan); Hirose, M. [Nuclear Fuel Transport Co., Ltd., Tokyo (Japan); Kobayashi, T. [Nippon Chuzo, Kawasaki (Japan); Tezuka, Y. [Mitsubishi Materials Co., Tokyo (Japan); Urabe, N. [Kokan Keisoku K. K., Kawasaki (Japan); Hueggenberg, R. [GNB, Essen (Germany)

    2004-07-01

    The current Rules for Construction of ''Containment Systems for Storage and Transport Packagings of Spent Nuclear Fuel and High Level Radioactive Material and Waste'' of Division 3 in Section III of ASME Code (2001 Edition) does not include ductile cast iron in its list of materials permitted for use. The Rules specify required fracture toughness values of ferritic steel material for nominal wall thickness 5/8 to 12 inches (16 to 305 mm). New rule for ductile cast iron for transport packaging of which wall thickness is greater than 12 inches (305mm) is required.

  7. Parameter subset selection for the dynamic calibration of activated sludge models (ASMs): experience versus systems analysis

    DEFF Research Database (Denmark)

    Ruano, MV; Ribes, J; de Pauw, DJW

    2007-01-01

    In this work we address the issue of parameter subset selection within the scope of activated sludge model calibration. To this end, we evaluate two approaches: (i) systems analysis and (ii) experience-based approach. The evaluation has been carried out using a dynamic model (ASM2d) calibrated...... based approaches which excluded them from their analysis. Systems analysis reveals that parameter significance ranking and size of the identifiable parameter subset depend on the information content of data available for calibration. However, it suffers from heavy computational demand. In contrast...

  8. Biological phosphorus removal in an extended ASM2 model: Roles of extracellular polymeric substances and kinetic modeling.

    Science.gov (United States)

    Yang, Shan-Shan; Pang, Ji-Wei; Guo, Wan-Qian; Yang, Xiao-Yin; Wu, Zhong-Yang; Ren, Nan-Qi; Zhao, Zhi-Qing

    2017-05-01

    This paper presents the results of an extended ASM2 model for the modeling and calibration of the role of extracellular polymeric substances (EPS) in phosphorus (P) removal in an anaerobic-aerobic process. In this extended ASM2 model, two new components, the bound EPS (XEPS) and the soluble EPS (SEPS), are introduced. Compared with the ASM2, 7.71, 8.53, and 9.28% decreases in polyphosphate (polyP) were observed in the extended ASM2 in three sequencing batch reactors feeding with different COD/P ratios, indicating that 7.71-9.28% of P in the liquid was adsorbed by EPS. Sensitive analysis indicated that, five parameters were the significant influential parameters and had been chosen for further model calibration by using the least square method to simulate by MATLAB. This extended ASM2 has been successfully established to simulate the output variables and provides a useful reference for the mathematic simulations of the role of EPS in biological phosphorus removal process. Copyright © 2017. Published by Elsevier Ltd.

  9. OCLC and Its Advisory Committees.

    Science.gov (United States)

    Baker, Shirley K.

    1998-01-01

    Describes the Online Computer Library Center (OCLC) advisory committees in terms of research, public, college and university, and special libraries. All four of the type-of-library advisory groups work to shape OCLC policies and programs, according to the particular needs of each group. OCLC's financial and programmatic success depends upon…

  10. A Study of Assessing Errors and Completeness of Research Application Forms Submitted to Instituitional Ethics Committee (IEC) of a Tertiary Care Hospital.

    Science.gov (United States)

    Shah, Pruthak C; Panchasara, Ashwin K; Barvaliya, Manish J; Tripathi, C B

    2016-09-01

    Application form of research work is an essential requirement which is required to be submitted along with the research proposal to the Ethics Committee (EC). To check the completeness and to find the errors in application forms submitted to the EC of a tertiary care hospital. The application forms of research projects submitted to the Institutional Review Board (IRB), Government Medical College, Bhavnagar, Gujarat, India from January 2014 to June 2015 were analysed for completeness and errors, with respect to the following - type of study, information about study investigators, sample size, study participants, title of the studies, signatures of all investigators, regulatory approval, recruitment procedure, compensation to study participants, informed consent process, information about sponsor, declaration of conflict of interest, plans for storage and maintenance of data, patient information sheet, informed consent forms and study related documents. Total 100 application forms were analysed. Among them, 98 were academic and 2 were industrial studies. Majority of academic studies were of basic science type. In 63.26% studies, type of study was not mentioned in title. Age group of subjects was not mentioned in 8.16% application forms. In 34.6% informed consent, benefits of the study were not mentioned. Signature of investigators/co-investigators/Head of the Department was missing in 3.06% cases. Our study recommends that the efficiency and speed of review will increase if investigator will increase vigilance regarding filling of application forms. Regular meetings will be helpful to solve the problems related to content of application forms. The uniformity in functioning of EC can be achieved if common application form for all ECs is there.

  11. Report of the CIRRPC Executive Committee regarding EPA NESHAP regulations on radionuclides for medical research institutions and radiopharmaceutical manufacturers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-06-01

    There appears to be no compelling public health protection reason for EPA`s promulgation of NESHAP regulations to control air emissions of radioactive materials from NRC-licensed facilities engaged in activities associated with the practice and development of nuclear medicine. The NRC`s existing regulations provide the necessary controls for protection and EPA`s regulations would only add burdensome reporting requirements at substantial cost to medical treatment and diagnosis. Availability of nuclear medicine practice could be impacted and advancements through research delayed.

  12. Committee for international collaborative research of medical and welfare apparatus; Iryo fukushi kiki kokusai kyodo kenkyu jigyo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    The paper summarized activities for an investigational study on the international collaborative research project on the medical and welfare apparatus implemented in fiscal 1995. As investigation activities, the second meeting of information exchanges with E.U. and three north European countries was held following the meeting in fiscal 1994, and at the same time, information exchanges were made with organizations/institutions of industry/government/university in Germany, France and Canada. The study made it clear that Europe is also taking a direction of low-degree action diagnosis/care as Japan is. Further, concrete exchanges of information advanced and an awareness of the common issues was made clear such as the necessity of developing apparatus which meets the apparatus market and users` needs. As international collaborative activities, new methods of information exchanges were adopted such as the satellite meeting of the International MR Society, meetings with researchers who visited Japan. The satellite meeting of the International MR Society was favorably accepted by participants, and it was pointed out that it is important to continue the meeting in view of the materialization of themes, etc. 4 refs., 32 figs., 5 tabs.

  13. The Audit Committee. AGB Effective Committee Series

    Science.gov (United States)

    Staisloff, Richard L.

    2011-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  14. The Facilities Committee. AGB Effective Committee Series

    Science.gov (United States)

    Kaiser, Harvey H.

    2012-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  15. The Compensation Committee. AGB Effective Committee Series

    Science.gov (United States)

    Hyatt, Thomas K.

    2013-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  16. The Facilities Committee. AGB Effective Committee Series

    Science.gov (United States)

    Kaiser, Harvey H.

    2012-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  17. Electric Power Research Institute: Environmental Control Technology Center. Report to the Steering Committee, February 1996. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    Operations and maintenance continued this month at the Electric Power Research Institute`s Environmental Control Technology Center. Testing on the 4.0 MW Pilot Wet FGD unit continued this month with the Carbon Injection System and the Trace Element Removal test blocks. With this testing, the mercury measurement (Method 29) studies also continued with impinger capture solutions. The 4.0 MW Spray Dryer Absorber System (Carbon Injection System) was utilized in the TER test configuration this month. The B&W/CHX Heat Exchanger unit is being installed utilizing the Mini Pilot Flue Gas System. The 1.0 MW Cold- Side Selective Catalytic Reduction (SCR) unit remained idle this month in a cold-standby mode. Monthly inspections were conducted for all equipment in cold-standby, as well as for the fire safety systems, and will continue to be conducted by the ECTC Operations and Maintenance staff.

  18. Postharvest ASM or Harpin Treatment Induce Resistance of Muskmelons Against Trichothecium roseum

    Institute of Scientific and Technical Information of China (English)

    WANG Yi; LI Xuan; BI Yang; GE Yong-hong; LI Yong-cai; XIE Fang

    2008-01-01

    Induced resistance was studied in muskmelons(cv.Yindi)inoculated Trichothecium roseum with postharvest 1,2,3-benzothiadiazole-7-carbothioic acid S-methyl ester(ASM)(100 mg L-1)or harpin(50 mg L-1)treatment.Both ASM and harpin significantly reduced lesion diameter in inoculated fruit.Lesion diameter was limited in the treated and untreated halves of the same fruit,indicating that the local and systemic resistance was induced.Inhibiting efficacy of elicitors lasted 7 and 5 days in the treated and untreated halves.The resistance increased by the chemicals was associated with the activation of peroxidase(POD)and chitinase(CHT).The elicitors induced a significantly and progressively increasing activity of POD and CHT in the treated and untreated halves,and the activation lasted at least 5 days.The activities of POD isoenzymes increased in the treated fruit.However,no new enzyme band was found in the treated and untreated halves.

  19. Modelling the biological performance of a side-stream membrane bioreactor using ASM1

    Institute of Scientific and Technical Information of China (English)

    TIAN Ke-jun; LIU Xin-ai; JIANG Tao; M.D. Kennedy; J.C. Schippers; P.A. Vanrolleghem

    2004-01-01

    Membrane bioreactors(MBRs) are attracting global interest but the mathematical modeling of the biological performance of MBRs remains very limited. This study focuses on the modelling of a side-stream MBR system using Activated Sludge Model No.1(ASM1), and comparing the results with the modelling of traditional activated sludge processes. ASM1 parameters relevant for the long-term biological behaviour in MBR systems were calibrated(i.e. YH=0.72gCOD/gCOD, YA=0.25gCOD/gN, bH=0.25 d-1, bA=0.080 d-1 and fP=0.06), and generally agreed with the parameters in traditional activated sludge processes, with the exception that a higher autotrophic biomass decay rate was observed in the MBR. A sensitivity analysis for steady state operation and DO dynamics suggested that the biological performance of the MBR system(the sludge concentration, effluent quality and the DO dynamics) are very sensitive to the parameters(i.e. YH, YA, bH, bA, (maxH and (maxA), and influent wastewater components(XI, Ss, Xs, SNH).

  20. Code cases for implementing risk-based inservice testing in the ASME OM code

    Energy Technology Data Exchange (ETDEWEB)

    Rowley, C.W.

    1996-12-01

    Historically inservice testing has been reasonably effective, but quite costly. Recent applications of plant PRAs to the scope of the IST program have demonstrated that of the 30 pumps and 500 valves in the typical plant IST program, less than half of the pumps and ten percent of the valves are risk significant. The way the ASME plans to tackle this overly-conservative scope for IST components is to use the PRA and plant expert panels to create a two tier IST component categorization scheme. The PRA provides the quantitative risk information and the plant expert panel blends the quantitative and deterministic information to place the IST component into one of two categories: More Safety Significant Component (MSSC) or Less Safety Significant Component (LSSC). With all the pumps and valves in the IST program placed in MSSC or LSSC categories, two different testing strategies will be applied. The testing strategies will be unique for the type of component, such as centrifugal pump, positive displacement pump, MOV, AOV, SOV, SRV, PORV, HOV, CV, and MV. A series of OM Code Cases are being developed to capture this process for a plant to use. One Code Case will be for Component Importance Ranking. The remaining Code Cases will develop the MSSC and LSSC testing strategy for type of component. These Code Cases are planned for publication in early 1997. Later, after some industry application of the Code Cases, the alternative Code Case requirements will gravitate to the ASME OM Code as appendices.

  1. Ethics Committee or Community? Examining the identity of Czech Ethics Committees in the period of transition.

    Science.gov (United States)

    Simek, Jiri; Zamykalova, Lenka; Mesanyova, Marie

    2010-09-01

    Reflecting on a three year long exploratory research of ethics committees in the Czech Republic authors discuss the current role and identity of research ethics committees. The research of Czech ethics committees focused on both self-presentation and self-understanding of ECs members, and how other stakeholders (representatives of the pharmaceutical industry) view them. The exploratory research was based on formal and informal communication with the members of the ethics committees. Members of the research team took part at six regular voluntary meetings of the ethics committees' members, organised by the Forum of Czech Ethics Committees, and at three summer schools of medical ethics. There were realised twenty-five semi-structured interviews as well as six focus group sessions and a participant observation of several regular meetings of three ethics committees. On the grounds of experience from the interviews a simple questionnaire survey was realised among the members of the ethics committees. The ethics committees comprise a community of members working voluntarily, without claims to remuneration or prestige; the unifying goal is protection of subjects of research. The principal working methods are dialogue and agreement. The members of the ethics committees thus, among other things, create an informal community, which can be to a certain extent seen as a Kantian ethical community in a weak sense. The phenomenon of ethics committees can also be described by terms of an epistemic community and a community of practice. These concepts, which are borrowed from other authors and areas, are used as a way how to think of ECs role and identity a bit differently and are meant as a contribution to the current international debate on the topic.

  2. 3D automatic anatomy segmentation based on iterative graph-cut-ASM

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xinjian; Bagci, Ulas [Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Building 10 Room 1C515, Bethesda, Maryland 20892-1182 and Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi' an 710071 (China); Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Building 10 Room 1C515, Bethesda, Maryland 20892-1182 (United States)

    2011-08-15

    Purpose: This paper studies the feasibility of developing an automatic anatomy segmentation (AAS) system in clinical radiology and demonstrates its operation on clinical 3D images. Methods: The AAS system, the authors are developing consists of two main parts: object recognition and object delineation. As for recognition, a hierarchical 3D scale-based multiobject method is used for the multiobject recognition task, which incorporates intensity weighted ball-scale (b-scale) information into the active shape model (ASM). For object delineation, an iterative graph-cut-ASM (IGCASM) algorithm is proposed, which effectively combines the rich statistical shape information embodied in ASM with the globally optimal delineation capability of the GC method. The presented IGCASM algorithm is a 3D generalization of the 2D GC-ASM method that they proposed previously in Chen et al.[Proc. SPIE, 7259, 72590C1-72590C-8 (2009)]. The proposed methods are tested on two datasets comprised of images obtained from 20 patients (10 male and 10 female) of clinical abdominal CT scans, and 11 foot magnetic resonance imaging (MRI) scans. The test is for four organs (liver, left and right kidneys, and spleen) segmentation, five foot bones (calcaneus, tibia, cuboid, talus, and navicular). The recognition and delineation accuracies were evaluated separately. The recognition accuracy was evaluated in terms of translation, rotation, and scale (size) error. The delineation accuracy was evaluated in terms of true and false positive volume fractions (TPVF, FPVF). The efficiency of the delineation method was also evaluated on an Intel Pentium IV PC with a 3.4 GHZ CPU machine. Results: The recognition accuracies in terms of translation, rotation, and scale error over all organs are about 8 mm, 10 deg. and 0.03, and over all foot bones are about 3.5709 mm, 0.35 deg. and 0.025, respectively. The accuracy of delineation over all organs for all subjects as expressed in TPVF and FPVF is 93.01% and 0.22%, and

  3. Electric Power Research Institute: Environmental Control Technology Center report to the Steering Committee. Final technical monthly report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    Operations and maintenance continued this month at the Electric Power Research Institute`s Environmental Control Technology Center. Testing on the 4.0 MW Pilot Wet FGD unit continued this month with the Trace Element Removal test block (TER) as the Pilot was operated under forced oxidation conditions. With this testing, the mercury measurement (Method 29) studies also continued as investigations into various activated carbons, metal amalgams, and impinger capture solutions were conducted. Following these studies, a brief test of the Pilot High Velocity FGD configuration (PHV) was conducted. This test block will be continued at the end of the month after the Fall outage is completed. The 1.0 MW Cold-Side Selective Catalytic Reduction (SCR) unit remained idle this month in a cold-standby mode. During this month`s outage, the inlet and outlet damper plates were sealed to isolate the SCR system from flue gas. Also, the internals of the heat pipe heat exchanger (HPHE) and catalyst reactor tower were inspected and cleaned so that the system could be available for future test activities. Monthly inspections of all SCR system equipment placed in this cold-standby mode, as well as the fire safety systems in the SCR building, will continue to be conducted by the ECTC maintenance department and will include manual rotation of the booster fan.

  4. Politics of Elementary and Secondary Education. Committee on Basic Research in Education Research Workshop Report. (Stanford, California, September 14-19, 1970.) Working Document.

    Science.gov (United States)

    Kirst, Michael W.; Grossman, David L.

    The papers in this report fall into three focus areas: (1) new goals and objectives for educational institutions, with a stress on normative analysis of public policy alternatives and a reexamination of prior assumptions on which research is based; (2) the political education of youth, with a particular examination of directions in research on…

  5. 太钢通过ASME MO(材料组织)核电认证

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    近日,美国机械工程师协会(ASME)正式公布太钢获得了ASME MO(材料组织)核电产品质量体系认证书,标志着太钢成为中国首家通过ASME MO核电认证的钢铁企业,太钢将有资格按照ASME标准和质量体系要求制造核电产品。

  6. Medical imaging in personalised medicine: a white paper of the research committee of the European Society of Radiology (ESR).

    Science.gov (United States)

    2015-04-01

    The future of medicine lies in early diagnosis and individually tailored treatments, a concept that has been designated 'personalised medicine' (PM), which aims to deliver the right treatment to the right patient at the right time. Medical imaging has always been personalised and is fundamental to almost all aspects of PM. It is instrumental in solving clinical differential diagnoses. Imaging procedures are tailored to the clinical problem and patient characteristics. Screening for preclinical disease is done with imaging. Stratification based on imaging biomarkers can help identify individuals suited for preventive intervention. Treatment decisions are based on the in vivo visualisation of the location and extent of an abnormality, as well as the loco-regional physiological, biochemical and biological processes using structural and molecular imaging. Image-guided biopsy provides relevant tissue specimens for genetic/molecular characterisation. In addition, radiogenomics relate imaging biomarkers to these genetic and molecular features. Furthermore, imaging is essential to patient-tailored therapy planning, therapy monitoring and follow-up of disease, as well as targeting non-invasive or minimally invasive treatments, especially with the rise of theranostics. Radiologists need to be prepared for this new paradigm as it will mean changes in training, clinical practice and in research. Key Points • Medical imaging is a key component in personalised medicine • Personalised prevention will rely on image-based screening programmes • Anatomical, functional and molecular imaging biomarkers affect decisions on the type and intensity of treatment • Treatment response assessment with imaging will improve personalised treatment • Image-based invasive intervention integrates personalised diagnosis and personalised treatment.

  7. A regulator`s perspective on NRC`s participation in the operations & maintenance committees

    Energy Technology Data Exchange (ETDEWEB)

    Wessman, R.H.

    1996-12-01

    As a regulator fairly new to the American Society of Mechanical Engineers (ASME) Operations and Maintenance (O&M) Committee process, the author does not have a personal historical perspective as do many of the longer-term, and highly respected, members of the O&M Committee. However, as Branch Chief of the Mechanical Engineering Branch, Division of Engineering, in the Office of Nuclear Reactor Regulation at the NRC for just over two years, he has responsibility for the regulatory agency`s review of licensee actions involving the products that come from the efforts of the O&M Committee, as well as responsibility for portions of the activities of interest to other ASME Code groups such as Section III, Section XI, and Qualification of Mechanical Equipment. As a result, the author has learned a great deal about the code process in a short time. Here he gives his perspectives on the process and provides a few thoughts on the direction for the future.

  8. 76 FR 48117 - Committee on Rulemaking

    Science.gov (United States)

    2011-08-08

    ....@acus.gov. Click on ``Research,'' then on ``Conference Projects,'' and then on ``Agency Innovations in e-Rulemaking.'' Comments may be submitted by e-mail to Comments@acus.gov , with ``Committee on Rulemaking''...

  9. 76 FR 58237 - Committee on Rulemaking

    Science.gov (United States)

    2011-09-20

    ....acus.gov . Click on ``Research'' -> ``Conference Projects'' -> ``Agency Innovations in e-Rulemaking.'' Comments may be submitted by e-mail to Comments@acus.gov , with ``Committee on Rulemaking'' in the...

  10. CCCT - NCORP Cancer Control Steering Committees

    Science.gov (United States)

    The National Community Oncology Research Program (NCORP) Steering Committees review concepts for clinical trials to control cancer symptoms and cancer treatment side effects, and concepts for studies of cancer care delivery.

  11. Scientific Programme Committee

    Science.gov (United States)

    2013-02-01

    Scientific Programme Committee A. Blondel, University of Geneva A. Cervera, IFIC M. Dracos, IN2P3 I. Efhymiopoulos, CERN J. Ellis, CERN S. Geer, FNAL R. Garoby, CERN M. Goodman, ANL D. Harris, FNAL T. Hasegawa, KEK P. Huber, Virginia Tech. D. Kaplan, IIT Y.D. Kim, Sejong University H. Kirk, BNL Y. Kuno, Osaka University K. Long, Imperial College N.K. Mondal, TIFR J. Morfin, FNAL Y. Mori, Kyoto University K. Nishikawa, KEK V. Palladino, University of Napoli C. Prior, RAL F.J.P. Soler, University of Glasgow J. Strait, FNAL R. Svoboda, University of California Davis F. Terranova, LN Frascati M. Zisman, LBNL Local Organizing Committee E. Benedetto, CERN/NTUA C. Blanchard, University of Geneva A. Blondel, University of Geneva (co-chair) I. Efthymiopoulos, CERN (co-chair) F. Dufour, University of Geneva F. Girard-Madoux, CERN E. Gschwendtner, CERN A. Korzenev, University of Geneva M. Morer-Olafsen, CERN S. Murphy, University of Geneva G. Prior, CERN G. Wikström, University of Geneva E. Wildner, CERN Sponsors EuCARD European Organization for Nuclear Research (CERN) Swiss Institute for Particle Physics (CHIPP) University of Geneva

  12. Association of Finnish Members of Parliament and Researchers: Social Democratic Parliamentary group MP K. Olin, Former Finnish MP M. Tiuri, Finnish Centre Party MP P. Vilkuna, Senior Assistant Professor I. Ruostetsaari and Finnish Parliament Committee of Future Researcher U. Gabrielsson at ATLAS experiment with P. Jenn, M. Nordberg and M. Kotamaki on 15 September 2006.

    CERN Document Server

    Maximilien Brice

    2006-01-01

    Association of Finnish Members of Parliament and Researchers: Social Democratic Parliamentary group MP K. Olin, Former Finnish MP M. Tiuri, Finnish Centre Party MP P. Vilkuna, Senior Assistant Professor I. Ruostetsaari and Finnish Parliament Committee of Future Researcher U. Gabrielsson at ATLAS experiment with P. Jenn, M. Nordberg and M. Kotamaki on 15 September 2006.

  13. Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca(2+) regulation in airway smooth muscle (ASM).

    Science.gov (United States)

    Delmotte, Philippe; Sieck, Gary C

    2015-02-01

    Airway inflammation is a key aspect of diseases such as asthma. Several inflammatory cytokines (e.g., TNFα and IL-13) increase cytosolic Ca(2+) ([Ca(2+)]cyt) responses to agonist stimulation and Ca(2+) sensitivity of force generation, thereby enhancing airway smooth muscle (ASM) contractility (hyper-reactive state). Inflammation also induces ASM proliferation and remodeling (synthetic state). In normal ASM, the transient elevation of [Ca(2+)]cyt induced by agonists leads to a transient increase in mitochondrial Ca(2+) ([Ca(2+)]mito) that may be important in matching ATP production with ATP consumption. In human ASM (hASM) exposed to TNFα and IL-13, the transient increase in [Ca(2+)]mito is blunted despite enhanced [Ca(2+)]cyt responses. We also found that TNFα and IL-13 induce reactive oxidant species (ROS) formation and endoplasmic/sarcoplasmic reticulum (ER/SR) stress (unfolded protein response) in hASM. ER/SR stress in hASM is associated with disruption of mitochondrial coupling with the ER/SR membrane, which relates to reduced mitofusin 2 (Mfn2) expression. Thus, in hASM it appears that TNFα and IL-13 result in ROS formation leading to ER/SR stress, reduced Mfn2 expression, disruption of mitochondrion-ER/SR coupling, decreased mitochondrial Ca(2+) buffering, mitochondrial fragmentation, and increased cell proliferation.

  14. 46 CFR 54.01-2 - Adoption of division 1 of section VIII of the ASME Boiler and Pressure Vessel Code.

    Science.gov (United States)

    2010-10-01

    ... Boiler and Pressure Vessel Code. 54.01-2 Section 54.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (a) Pressure vessels shall be designed, constructed, and inspected in accordance with section VIII of the ASME Boiler and Pressure...

  15. Replacement of radiography with ultrasonic phased array for feeder tubes in CANDU reactors using ASME code case N-659-2

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, R.; Bower, Q.; Arseneau, S., E-mail: bsimmons@metalogicinspection.com, E-mail: qbower@metalogicinspection.com, E-mail: sarseneau@metalogicinspection.com [Metalogic Inspection Services, Edmonton, Alberta (Canada)

    2013-07-01

    In this paper we will discuss phased array technology for the replacement of radiography on new construction projects in the nuclear industry. Specifically, through the implementation of A.S.M.E. code N-659-2 and MetaPhase phased array services. Phased Array is not considered a new technique on in service welds in the nuclear industry; however it was unprecedented on new construction welds and required significant investment in regulatory approval (C.N.S.C.), technology research and development, regulatory, client and technician training for successful service implementation. This paper will illustrate the abilities and limitations associated in replacing radiography with MetaPhase, as well as the substantial benefits relative to increased production, improved weld quality, enhanced safety and overall project cost savings. (author)

  16. Calidad de la atención primaria en el paciente asmático

    Directory of Open Access Journals (Sweden)

    Patricia Varona Pérez

    1998-02-01

    Full Text Available Se ejecuta una investigación en servicios de salud con el objetivo de evaluar la calidad de la atención primaria en el paciente asmático en Ciudad de La Habana, mediante un diseño transversal, que incluyó pacientes asmáticos de los municipios Regla, Arroyo Naranjo y Cerro, seleccionados de forma aleatoria dentro de cada estrato, conformado según la tasa de mortalidad de 1993 a 1995. Se estudian 611 pacientes por medio de un cuestionario contentivo de variables sociodemográficas, relacionadas con conocimientos de la enfermedad, conducta del asmático y servicios vinculados con éste. Se muestra en los principales resultados que la atención brindada fue deficiente, expresada en escasos conocimientos del paciente sobre el manejo de su enfermedad y sus determinantes; conducta inadecuada ante una crisis y en períodos intercrisis; insuficiente atención por el psicólogo y el rehabilitador, en contraste con la aceptable satisfacción de los pacientes con la atención recibida. Se recomienda acciones orientadas a perfeccionar la capacitación del personal de salud, con énfasis en el enfoque preventivo de esta enfermedadAn investigation on the health services was carried out aimed at evaluating the quality of primary health care in the asthmatic patient, in Havana City, by a cross-sectional design that included asthmatics from the municipalities of Regla, Arroyo Naranjo and Cerro, who were selected at random within each stratum formed according to the mortality rate from 1993 to 1995. 611 patients were studied by using a questionnaire incluiding socidemographic variables connected with knowledge about the disease, behavior of the asthmatic and services linked with him. The main results showed that the attention was deficient, that the patient knew a little about the management of the disease and its determinants, that there was an inadequate conduct during the crisis and the intercrisis periods, and that the attention given by the

  17. 75 FR 80765 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

    Science.gov (United States)

    2010-12-23

    ... submitting the document (or signing the document, if submitted on behalf of an association, business, labor... membership professional organization that enables collaboration, knowledge-sharing, and skill development across all engineering disciplines. ASME is recognized globally for its leadership in providing the...

  18. Impact of the A18.1 ASME Standard on Platform Lifts and Stairway Chairlifts on Accessibility and Usability

    Science.gov (United States)

    Balmer, David C.

    2010-01-01

    This article summarizes the effect of the ASME A18.1 Standard concerning accessibility and usability of Platform Lifts and their remaining technological challenges. While elevators are currently the most effective means of vertical transportation related to speed, capacity, rise and usability, their major drawbacks for accessibility are cost and…

  19. 76 FR 11191 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

    Science.gov (United States)

    2011-03-01

    ... Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code AGENCY... Pressure Vessel Code, Section XII (2010 Edition) and the National Board of Boiler and Pressure Vessel Inspectors' National Board Inspection Code (2007 Edition). Further, PHMSA is extending the comment period...

  20. Acid sphingomyelinase (Asm) deficiency patients in The Netherlands and Belgium: Disease spectrum and natural course in attenuated patients

    NARCIS (Netherlands)

    Hollak, C.E.M.; Sonnaville, E.S. de; Cassiman, D.; Linthorst, G.E.; Groener, J.E.M.; Morava, E.; Wevers, R.A.; Mannens, M.; Aerts, J.M.F.G.; Meersseman, W.; Akkerman, E.; Niezen-Koning, K.E.; Mulder, M.F.; Visser, G.; Wijburg, F.A.; Lefeber, D.; Poorthuis, B.J.H.M.

    2012-01-01

    Niemann-Pick disease (NPD) is a neurovisceral lysosomal storage disorder caused by acid sphingomyelinase (ASM) deficiency, which can be categorized as either Niemann-Pick disease type A [NPD-A], with progressive neurological disease and death in early childhood, or as Niemann-Pick disease type B [NP

  1. Reaction invariant-based reduction of the activated sludge model ASM1 for batch applications

    DEFF Research Database (Denmark)

    Santa Cruz, Judith A.; Mussati, Sergio F.; Scenna, Nicolás J.

    2016-01-01

    that are unaffected by the reaction progress, i.e. so-called reaction invariants. The reaction invariant concept can be used to reduce the number of ordinary differential equations (ODEs) involved in batch bioreactor models. In this paper, a systematic methodology of model reduction based on this concept is applied...... to batch activated sludge processes described by the Activated Sludge Model No. 1 (ASM1) for carbon and nitrogen removal. The objective of the model reduction is to describe the exact dynamics of the states predicted by the original model with a lower number of ODEs. This leads to a reduction...... of the numerical complexity as nonlinear ODEs are replaced by linear algebraic relationships predicting the exact dynamics of the original model....

  2. ASME B89.4.19 Performance Evaluation Tests and Geometric Misalignments in Laser Trackers.

    Science.gov (United States)

    Muralikrishnan, B; Sawyer, D; Blackburn, C; Phillips, S; Borchardt, B; Estler, W T

    2009-01-01

    Small and unintended offsets, tilts, and eccentricity of the mechanical and optical components in laser trackers introduce systematic errors in the measured spherical coordinates (angles and range readings) and possibly in the calculated lengths of reference artifacts. It is desirable that the tests described in the ASME B89.4.19 Standard [1] be sensitive to these geometric misalignments so that any resulting systematic errors are identified during performance evaluation. In this paper, we present some analysis, using error models and numerical simulation, of the sensitivity of the length measurement system tests and two-face system tests in the B89.4.19 Standard to misalignments in laser trackers. We highlight key attributes of the testing strategy adopted in the Standard and propose new length measurement system tests that demonstrate improved sensitivity to some misalignments. Experimental results with a tracker that is not properly error corrected for the effects of the misalignments validate claims regarding the proposed new length tests.

  3. Change of nonlinear acoustics in ASME grade 122 steel welded joint during creep

    Science.gov (United States)

    Ohtani, Toshihiro; Honma, Takumi; Ishii, Yutaka; Tabuchi, Masaaki; Hongo, Hiromichi; Hirao, Masahiko

    2016-02-01

    In this paper, we described the changes of two nonlinear acoustic characterizations; resonant frequency shift and three-wave interaction, with electromagnetic acoustic resonance (EMAR) throughout the creep life in the welded joints of ASME Grade 122, one of high Cr ferritic heat resisting steels. EMAR was a combination of the resonant acoustic technique with a non-contact electromagnetic acoustic transducer (EMAT). These nonlinear acoustic parameters decreased from the start to 50% of creep life. After slightly increased, they rapidly increased from 80% of creep life to rupture. We interpreted these phenomena in terms of dislocation recovery, recrystallization, and restructuring related to the initiation and growth of creep void, with support from the SEM and TEM observation.

  4. Flanged joints with contact outside the bolt circle: ASME Part B design rules

    Energy Technology Data Exchange (ETDEWEB)

    Rodabaugh, E. C.; Moore, S. E.

    1976-05-01

    The ASME Boiler and Pressure Vessel Code, Section VIII, Division 1, gives rules which are subdivided into ''Part A'' and ''Part B''. Part A covers flanged joints where contact between flanges occurs through a gasket located inside the bolt holes. Part B covers flanged joints with contact outside the bolt holes. This report (a) summarizes the theory for Part B flanged joints, (b) presents examples which show the significant differences between Part A flanged joints and Part B flanged joints, (c) presents the available test data relevant to the characteristics of Part B flanged joints, (d) gives listings of two computer programs which can be used to evaluate the characteristics of Part B flanged joints, and (e) gives recommendations for Code revisions and other aspects of Part B flanged-joint design.

  5. ASME power test code ptc 4.1 for steam generators; Codigo de pruebas de potencia ASME ptc 4.1 para generadores de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Plauchu Alcantara, Jorge Alberto [Plauchu Consultores, Morelia, Michoacan (Mexico)

    2001-07-01

    This presentation is oriented towards those who in this subject have experience in the design and equipment specification, plant projects, factory and field testing, operation or result analyses. An important fraction of the national energy supply, approximately 13%, is applied to the steam generation in the different aspects of the industrial activity, in the electrical industry of public service and in the commercial and services sector. The development of the national programs of energy efficiency verifies this when dedicating to this use of the energy important projects, some of them with support of the USAID. The measurement of the energy utilization or the efficiency of steam generators (or boilers) is made applying some procedure agreed by the parts and the one of greater acceptance and best known in Mexico and internationally is the ASME Power Test Code PTC 4.1 for Steam Generators. The purpose and formality in the determination of efficiency and of steam generation capacity behavior, thermal basic regime or fulfillment of guarantees, radically changes the exigencies of strict attachment to the PTC 4.1 This definition will determine the importance of the test method selected, the deviations and convened exceptions, the influence of the precision and the measurement errors, the consideration of auxiliary equipment, etc. An interpretation or incorrect application of the Test Code has lead and will lead to results and nonreliable decisions. [Spanish] Esta exposicion se orienta a quienes en este tema cuenta con experiencia en diseno y especificacion de equipo, proyecto de planta, pruebas en fabrica y campo, operacion o analisis de resultados. Una fraccion importante de la oferta nacional de energia, 13% aproximadamente, se aplica a la generacion de vapor en diferentes giros de actividad industrial, en la industria electrica, de servicio publico y en el sector de servicios y comercial. El desarrollo de los programas nacionales de eficiencia energetica comprueba

  6. Corticosteroid-Induced MKP-1 Represses Pro-Inflammatory Cytokine Secretion by Enhancing Activity of Tristetraprolin (TTP) in ASM Cells.

    Science.gov (United States)

    Prabhala, Pavan; Bunge, Kristin; Ge, Qi; Ammit, Alaina J

    2016-10-01

    Exaggerated cytokine secretion drives pathogenesis of a number of chronic inflammatory diseases, including asthma. Anti-inflammatory pharmacotherapies, including corticosteroids, are front-line therapies and although they have proven clinical utility, the molecular mechanisms responsible for their actions are not fully understood. The corticosteroid-inducible gene, mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1, DUSP1) has emerged as a key molecule responsible for the repressive effects of steroids. MKP-1 is known to deactivate p38 MAPK phosphorylation and can control the expression and activity of the mRNA destabilizing protein-tristetraprolin (TTP). But whether corticosteroid-induced MKP-1 acts via p38 MAPK-mediated modulation of TTP function in a pivotal airway cell type, airway smooth muscle (ASM), was unknown. While pretreatment of ASM cells with the corticosteroid dexamethasone (preventative protocol) is known to reduce ASM synthetic function in vitro, the impact of adding dexamethasone after stimulation (therapeutic protocol) had not been explored. Whether dexamethasone modulates TTP in a p38 MAPK-dependent manner in this cell type was also unknown. We address this herein and utilize an in vitro model of asthmatic inflammation where ASM cells were stimulated with the pro-asthmatic cytokine tumor necrosis factor (TNF) and the impact of adding dexamethasone 1 h after stimulation assessed. IL-6 mRNA expression and protein secretion was significantly repressed by dexamethasone acting in a temporally distinct manner to increase MKP-1, deactivate p38 MAPK, and modulate TTP phosphorylation status. In this way, dexamethasone-induced MKP-1 acts via p38 MAPK to switch on the mRNA destabilizing function of TTP to repress pro-inflammatory cytokine secretion from ASM cells. J. Cell. Physiol. 231: 2153-2158, 2016. © 2016 Wiley Periodicals, Inc.

  7. Spectrum of SMPD1 mutations in Asian-Indian patients with acid sphingomyelinase (ASM)-deficient Niemann-Pick disease.

    Science.gov (United States)

    Ranganath, Prajnya; Matta, Divya; Bhavani, Gandham SriLakshmi; Wangnekar, Savita; Jain, Jamal Mohammed Nurul; Verma, Ishwar C; Kabra, Madhulika; Puri, Ratna Dua; Danda, Sumita; Gupta, Neerja; Girisha, Katta M; Sankar, Vaikom H; Patil, Siddaramappa J; Ramadevi, Akella Radha; Bhat, Meenakshi; Gowrishankar, Kalpana; Mandal, Kausik; Aggarwal, Shagun; Tamhankar, Parag Mohan; Tilak, Preetha; Phadke, Shubha R; Dalal, Ashwin

    2016-10-01

    Acid sphingomyelinase (ASM)-deficient Niemann-Pick disease is an autosomal recessive lysosomal storage disorder caused by biallelic mutations in the SMPD1 gene. To date, around 185 mutations have been reported in patients with ASM-deficient NPD world-wide, but the mutation spectrum of this disease in India has not yet been reported. The aim of this study was to ascertain the mutation profile in Indian patients with ASM-deficient NPD. We sequenced SMPD1 in 60 unrelated families affected with ASM-deficient NPD. A total of 45 distinct pathogenic sequence variants were found, of which 14 were known and 31 were novel. The variants included 30 missense, 4 nonsense, and 9 frameshift (7 single base deletions and 2 single base insertions) mutations, 1 indel, and 1 intronic duplication. The pathogenicity of the novel mutations was inferred with the help of the mutation prediction software MutationTaster, SIFT, Polyphen-2, PROVEAN, and HANSA. The effects of the identified sequence variants on the protein structure were studied using the structure modeled with the help of the SWISS-MODEL workspace program. The p. (Arg542*) (c.1624C>T) mutation was the most commonly identified mutation, found in 22% (26 out of 120) of the alleles tested, but haplotype analysis for this mutation did not identify a founder effect for the Indian population. To the best of our knowledge, this is the largest study on mutation analysis of patients with ASM-deficient Niemann-Pick disease reported in literature and also the first study on the SMPD1 gene mutation spectrum in India. © 2016 Wiley Periodicals, Inc.

  8. Verification of Allowable Stresses In ASME Section III Subsection NH For Grade 91 Steel & Alloy 800H

    Energy Technology Data Exchange (ETDEWEB)

    R. W. Swindeman; M. J. Swindeman; B. W. Roberts; B. E. Thurgood; D. L. Marriott

    2007-11-30

    The database for the creep-rupture of 9Cr-1Mo-V (Grade 91) steel was collected and reviewed to determine if it met the needs for recommending time-dependent strength values, S{sub t}, for coverage in ASME Section III Subsection NH (ASME III-NH) to 650 C (1200 F) and 600,000 hours. The accumulated database included over 300 tests for 1% total strain, nearly 400 tests for tertiary creep, and nearly 1700 tests to rupture. Procedures for analyzing creep and rupture data for ASME III-NH were reviewed and compared to the procedures used to develop the current allowable stress values for Gr 91 for ASME II-D. The criteria in ASME III-NH for estimating S{sub t} included the average strength for 1% total strain for times to 600,000 hours, 80% of the minimum strength for tertiary creep for times to 600,000 hours, and 67% of the minimum rupture strength values for times to 600,000 hours. Time-temperature-stress parametric formulations were selected to correlate the data and make predictions of the long-time strength. It was found that the stress corresponding to 1% total strain and the initiation of tertiary creep were not the controlling criteria over the temperature-time range of concern. It was found that small adjustments to the current values in III-NH could be introduced but that the existing values were conservative and could be retained. The existing database was found to be adequate to extend the coverage to 600,000 hours for temperatures below 650 C (1200 F).

  9. The Use of Radio and Television in Education and Training. Report of the Main Committee of the HSRC Education Research Programme.

    Science.gov (United States)

    Human Sciences Research Council, Pretoria (South Africa).

    This report describes the findings of a work committee on learning needs and media utilization, which conducted an investigation of: (1) the learning needs that exist at the macrolevel in South Africa in informal, formal, and nonformal education; (2) those needs that can be satisfied by the use of educational radio (ER) and educational television…

  10. 中政会行政效率研究(1924-1937)%The Central Political Committee of the administrative efficiency research(1924-1937)

    Institute of Scientific and Technical Information of China (English)

    徐家贵

    2014-01-01

    中政会作为党与政府的连锁机关,是国民党政治的重要组成部分,其行政效率如何,直接影响着国民党及整个政治体制。笔者从中政会委员人数、委员兼职及会议体制三方面,对制约中政会行政效率的要素展开宏观与微观分析,揭示中政会会而不议、议而不决、决而不行的成因及其与国民党政治体制的关系。%The Central Political Committee as a chain between the party and government organs, which is an important part of the kuomintang political. The administrative efficiency of The Central Political Committee directly affect the operation of the kuomintang and the entire political system. This article discusses three aspects from the number of members, committee members part-time and conference system, through the analysis to the administrative efficiency restricting factors in the macro and micro, revealing The Central Political Committee without discuss, discuss without decisions, make decisions without execution of genesis and its relationship with the kuomintang political system.

  11. Committee Reports, May 2008

    Science.gov (United States)

    2008-08-01

    The Division's Executive Committee conducted several items of business at the New Orleans meeting. Elsewhere in this issue [see p 1032] is a listing of the candidates for Division offices for Fall 2008 election, approved by the Committee and later affirmed at the Division business meeting. Among items of specific interest to Division members is a plan to have the Journal of Chemical Education send an announcement to members when each issues goes online, and the Committee approved this use of the Division email list. It also approved plans presented by Amina El-Ashmawy and the BCCE committee to proceed with a bid from Pennsylvania State University for the 2012 BCCE.

  12. Consensus, contracts, and committees.

    Science.gov (United States)

    Moreno, J D

    1991-08-01

    Following a brief account of the puzzle that ethics committees present for the Western Philosophical tradition, I will examine the possibility that social contract theory can contribute to a philosophical account of these committees. Passing through classical as well as contemporary theories, particularly Rawls' recent constructivist approach, I will argue that social contract theory places severe constraints on the authority that may legitimately be granted to ethics committees. This, I conclude, speaks more about the suitability of the theory to this level of analysis than about the ethics committee phenomenon itself.

  13. 77 FR 57638 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-09-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... new measures; Formal safety assessment; Piracy and armed robbery against ships; Implementation...

  14. 75 FR 64390 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-10-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... --Formal safety assessment --Piracy and armed robbery against ships --General cargo ship...

  15. 76 FR 19176 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-04-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct two... safety --Piracy and armed robbery against ships --Implementation of instruments and related...

  16. 78 FR 29201 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-05-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... new measures Formal safety assessment Piracy and armed robbery against ships Implementation...

  17. Probabilistic Tsunami Hazard Assessment along Nankai Trough (1) An assessment based on the information of the forthcoming earthquake that Earthquake Research Committee(2013) evaluated

    Science.gov (United States)

    Hirata, K.; Fujiwara, H.; Nakamura, H.; Osada, M.; Morikawa, N.; Kawai, S.; Ohsumi, T.; Aoi, S.; Yamamoto, N.; Matsuyama, H.; Toyama, N.; Kito, T.; Murashima, Y.; Murata, Y.; Inoue, T.; Saito, R.; Takayama, J.; Akiyama, S.; Korenaga, M.; Abe, Y.; Hashimoto, N.

    2015-12-01

    The Earthquake Research Committee(ERC)/HERP, Government of Japan (2013) revised their long-term evaluation of the forthcoming large earthquake along the Nankai Trough; the next earthquake is estimated M8 to 9 class, and the probability (P30) that the next earthquake will occur within the next 30 years (from Jan. 1, 2013) is 60% to 70%. In this study, we assess tsunami hazards (maximum coastal tsunami heights) in the near future, in terms of a probabilistic approach, from the next earthquake along Nankai Trough, on the basis of ERC(2013)'s report. The probabilistic tsunami hazard assessment that we applied is as follows; (1) Characterized earthquake fault models (CEFMs) are constructed on each of the 15 hypothetical source areas (HSA) that ERC(2013) showed. The characterization rule follows Toyama et al.(2015, JpGU). As results, we obtained total of 1441 CEFMs. (2) We calculate tsunamis due to CEFMs by solving nonlinear, finite-amplitude, long-wave equations with advection and bottom friction terms by finite-difference method. Run-up computation on land is included. (3) A time predictable model predicts the recurrent interval of the present seismic cycle is T=88.2 years (ERC,2013). We fix P30 = 67% by applying the renewal process based on BPT distribution with T and alpha=0.24 as its aperiodicity. (4) We divide the probability P30 into P30(i) for i-th subgroup consisting of the earthquakes occurring in each of 15 HSA by following a probability re-distribution concept (ERC,2014). Then each earthquake (CEFM) in i-th subgroup is assigned a probability P30(i)/N where N is the number of CEFMs in each sub-group. Note that such re-distribution concept of the probability is nothing but tentative because the present seismology cannot give deep knowledge enough to do it. Epistemic logic-tree approach may be required in future. (5) We synthesize a number of tsunami hazard curves at every evaluation points on coasts by integrating the information about 30 years occurrence

  18. Special Committee on Financial Reporting: interim report

    National Research Council Canada - National Science Library

    Holder, William W

    1993-01-01

    ... information about the nature of information that is useful to those making investment and credit decisions and about how information is used in decision making processes. Commissioned Research Projects The Committee commissioned two separate research projects, both of which involved obtaining the services of independent researchers. The first...

  19. Ethics committees in Croatia

    NARCIS (Netherlands)

    Borovecki, Ana

    2007-01-01

    In this thesis the work of ethics committees in Croatia is being investigated for the first time. The 1997 Law on Health Protection introduced legal standards for the establishment of the so-called 'mixed' type of ethics committees in healthcare institutions. Our study aims to examine whether this t

  20. ASME 规范对核设备制造和运行期间的无损检验要求对比%Differences of NDT Technology Requirement between Manufacture and Operation Period of Nuclear Equipment in ASME Code

    Institute of Scientific and Technical Information of China (English)

    葛亮; 蔡家藩; 聂勇; 梁平

    2016-01-01

    对比分析了美国机械工程师协会(ASME)规范对核设备在制造和运行阶段中,在检验范围、检验技术和验收准则等方面的无损检验要求,对存在的差异进行了归纳总结。%This paper takes the ASME code as an example to describe the requirement of NDT for nuclear equipment in Manufacture and Operation Periods,and to analyze and compare the corresponding requirements of inspection scope,technique and acceptance standard in this two period,as well as,the sum-up the difference.

  1. Characteristics and Applied Limits for the Test Code ASME PTC 6.2 of Steam Turbine Performance%汽轮机性能试验规程ASME PTC6.2的特点及适用范围

    Institute of Scientific and Technical Information of China (English)

    刘利; 张敏

    2011-01-01

    对美国机械工程师学会制定的试验规程ASME PTC 6.2中蒸汽轮机的试验特点和试验方法等(联合循环)进行了系统阐述.ASME PTC 6.2规程具有边界条件、二元加法修正法等特点,适用于各种形式联合循环中汽轮机性能试验.将ASME PTC 6.2、ASME PTC 6和ASME PTC 46规程进行了比较分析,指出了规程的适用范围,得出了相关结论.

  2. The Compensation Committee. Effective Committees. Board Basics.

    Science.gov (United States)

    Tranquada, Robert E.

    2001-01-01

    This booklet describes some of the practices of committees charged with setting the compensation of the college or university president or chancellor. Whether the institution is private or public, the president's income will become public information, and apart from any public relations implications, it simply makes good sense for the compensation…

  3. Considerations on fatigue stress range calculations in nuclear power plants using on-line monitoring systems and the ASME Code

    Energy Technology Data Exchange (ETDEWEB)

    Cicero, R., E-mail: ciceror@unican.e [INESCO INGENIEROS S.L., Santander (Spain); Departamento de Ciencia e Ingenieria del Terreno y los Materiales, Universidad de Cantabria, Santander (Spain); Cicero, S. [Departamento de Ciencia e Ingenieria del Terreno y los Materiales, Universidad de Cantabria, Santander (Spain); Gorrochategui, I. [Centro Tecnologico de Componentes, Santander (Spain); Lacalle, R. [INESCO INGENIEROS S.L., Santander (Spain); Departamento de Ciencia e Ingenieria del Terreno y los Materiales, Universidad de Cantabria, Santander (Spain)

    2010-01-15

    Nuclear power plants are generally designed and inspected according to the ASME Code. This code indicates stress intensity (S{sub INT}) as the parameter to be used in the stress analysis of components. One of the particularities of S{sub INT} is that it always takes positive values, independently of the nature of the stress (tensile or compressive). This circumstance is relevant in the Fatigue Monitoring Systems used in nuclear power plants, due to the manner in which the different variable stresses are combined in order to obtain the final total stress range. This paper describes some situations derived from the application of the ASME Code, shows different ways of dealing with them and illustrates their influence on the evaluation of the fatigue usage factor through a case study.

  4. Cyclic-load crack growth in ASME SA-105 grade II steel in high-pressure hydrogen at ambient temperature

    Science.gov (United States)

    Walter, R. J.; Chandler, W. T.

    1976-01-01

    ASME SA-105 Grade II steel, which is used in high-pressure hydrogen compressor systems, is similar to steels used or considered for use in high-pressure hydrogen storage vessels and pipelines. This paper summarizes the results of a program conducted to provide cyclic-load crack growth rate (da/dN) data for a fracture mechanics analysis of a 15,000 psi hydrogen compressor facility which contains pulse quieter and after-cooler separator vessels constructed of the ASME SA-105 Grade II steel. Included in the program were tests performed to assist in establishing operating procedures that could minimize the effect of hydrogen on crack growth rates during operation.

  5. Flujo espiratorio máximo en niños asmáticos: Casos y controle.

    OpenAIRE

    Recabarren Lozada, Arturo; Apaza Atencio, Nelson

    2013-01-01

    Con el fin de determinar las variaciones del Flujo Espiratorio Máximo (PEF), se estudiaron a 38 niños asmáticos (CASOS) en período intercrítico de la enfermedad y a 38 niños sanos (CONTROLES), de ambos sexos comprendidos entre los 5 y 15 años de edad. Los niños asmáticos fueron clasificados por parámetros clínicos en determinado grado de severidad de asma bronquial, determinando el PEF de cada niño objeto de estudio conel mini-Wright Peak Flow Meter, en 2 registros diarios a los 06 y 18 horas...

  6. IL-17A acts via p38 MAPK to increase stability of TNF-alpha-induced IL-8 mRNA in human ASM.

    Science.gov (United States)

    Henness, Sheridan; van Thoor, Eveline; Ge, Qi; Armour, Carol L; Hughes, J Margaret; Ammit, Alaina J

    2006-06-01

    Human airway smooth muscle (ASM) plays an immunomodulatory role in asthma. Recently, IL-17A has become of increasing interest in asthma, being found at elevated levels in asthmatic airways and emerging as playing an important role in airway neutrophilia. IL-17A predominantly exerts its neutrophil orchestrating role indirectly via the induction of cytokines by resident airway structural cells. Here, we perform an in vitro study to show that although IL-17A did not induce secretion of the CXC chemokine IL-8 from ASM cells, IL-17A significantly potentiates TNF-alpha-induced IL-8 protein secretion and gene expression in a concentration- and time-dependent manner (P ASM cells, acting via a p38 MAPK-dependent posttranscriptional pathway to augment TNF-alpha-induced secretion of the potent neutrophil chemoattractant IL-8 from ASM cells.

  7. Función adrenal y metabolismo lipídico en niños asmáticos tratados con budesonida

    OpenAIRE

    Paoli-de Valeri Mariela; Zerpa-de Miliani Yajaira; Valeri-Dávila Ezio G.; Bellabarba Gabriela

    1999-01-01

    Objetivo. Evaluar el efecto de bajas dosis de budesonida inhalado sobre la función adrenal y el metabolismo lipídico en niños asmáticos. Material y métodos. Se estudiaron: 10 niños asmáticos (edad promedio, 8.6 años) tratados con budesonida inhalado (200-300 µg/día) por un lapso mayor a tres meses (grupo A); 15 niños asmáticos (edad promedio, 7.8 años) sin tratamiento esteroideo (grupo B), y 10 niños no asmáticos (grupo C). Se determinaron los niveles de cortisol basal y postestímulo con ACTH...

  8. Activated sludge model (ASM) based modelling of membrane bioreactor (MBR) processes: a critical review with special regard to MBR specificities.

    Science.gov (United States)

    Fenu, A; Guglielmi, G; Jimenez, J; Spèrandio, M; Saroj, D; Lesjean, B; Brepols, C; Thoeye, C; Nopens, I

    2010-08-01

    Membrane bioreactors (MBRs) have been increasingly employed for municipal and industrial wastewater treatment in the last decade. The efforts for modelling of such wastewater treatment systems have always targeted either the biological processes (treatment quality target) as well as the various aspects of engineering (cost effective design and operation). The development of Activated Sludge Models (ASM) was an important evolution in the modelling of Conventional Activated Sludge (CAS) processes and their use is now very well established. However, although they were initially developed to describe CAS processes, they have simply been transferred and applied to MBR processes. Recent studies on MBR biological processes have reported several crucial specificities: medium to very high sludge retention times, high mixed liquor concentration, accumulation of soluble microbial products (SMP) rejected by the membrane filtration step, and high aeration rates for scouring purposes. These aspects raise the question as to what extent the ASM framework is applicable to MBR processes. Several studies highlighting some of the aforementioned issues are scattered through the literature. Hence, through a concise and structured overview of the past developments and current state-of-the-art in biological modelling of MBR, this review explores ASM-based modelling applied to MBR processes. The work aims to synthesize previous studies and differentiates between unmodified and modified applications of ASM to MBR. Particular emphasis is placed on influent fractionation, biokinetics, and soluble microbial products (SMPs)/exo-polymeric substances (EPS) modelling, and suggestions are put forward as to good modelling practice with regard to MBR modelling both for end-users and academia. A last section highlights shortcomings and future needs for improved biological modelling of MBR processes.

  9. Flujo espiratorio máximo en niños asmáticos: Casos y controles

    Directory of Open Access Journals (Sweden)

    Arturo Recabarren Lozada

    1995-04-01

    Full Text Available Con el fin de determinar las variaciones del Flujo Espiratorio Máximo (PEF, se estudiaron a 38 niños asmáticos (CASOS en período intercrítico de la enfermedad y a 38 niños sanos (CONTROLES, de ambos sexos comprendidos entre los 5 y 15 años de edad. Los niños asmáticos fueron clasificados por parámetros clínicos en determinado grado de severidad de asma bronquial, determinando el PEF de cada niño objeto de estudio conel mini-Wright Peak Flow Meter, en 2 registros diarios a los 06 y 18 horas, durante 7 días consecutivos, obteniendo la variabilidad del mismo. Se encuentra diferencia en la variabilidad global de niños asmáticos de todos los grados de severidad de la enfermedad comprada con la de los niños normales, con diferencia estadística altamente significativa (p<0.000001. Las variaciones diurnas del PEF ayuda en el diagnóstico del asma bronquial y también son útiles para realizar la catalogación de severidad de la enfermedad. El PEF correlaciona bien con los síntomas presentados por los pacientes y por lo tanto guarda correspondencia con la Hiperreactividad bronquial (HRB del niño asmático. Postulamos que un niño con historia clínica sugestiva, una variabilidad global mayor del 8% indica que el diagnóstico de asma es altamente probable (Rev Med Hered 1995; 6: 76-82

  10. ASM-Triggered Too Observations of Kilohertz Oscillations in Three Atoll Sources

    Science.gov (United States)

    Kaaret, P.; Swank, Jean (Technical Monitor)

    2000-01-01

    Three Rossi Timing Explorer (RXTE) observations were carried out for this proposal based on target of opportunity triggers derived from the All-Sky Monitor (ASM) on RXTE. We obtained short observations of 4U1636-536 (15ks) and 4U1735-44 (23ks) and a longer observation of 4U0614+091 (117ks). Our analysis of our observations of the atoll neutron star x-ray binary 4U1735-44 lead to the discovery of a second high frequency quasiperiodic oscillation (QPO) in this source. These results were published in the Astrophysical Journal Letters. The data obtained on the source 4U0614+091 were used in a comprehensive study of this source, which will be published in the Astrophysical Journal. The data from this proposal were particularly critical for that study as they lead to the detection of the highest QPO frequency every found in the x-ray emission from an x-ray binary which will be important in placing limits on the equation of state of nuclear matter.

  11. 2016 ASMS Workshop Review: Next Generation LC/MS: Critical Insights and Future Perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Hongying; Makarov, Alexander; Smith, Richard D.

    2017-04-17

    The pilot workshop on BNext Generation LC/MS: Critical Insights and Future Perspectives was held on the evening of June 6, 2016 at the 64th ASMS Conference on Mass Spectrometry and Allied Topics held in San Antonio, TX. The workshop, chaired by Hongying Gao (Pfizer), consisted of stimulating talks from distinguished speakers and open discussion among the audience and invited presenters.The objectives of this workshop were to better understand the advances and limitations of current technologies; to exchange perspectives on the next generation LC/MS; and to discuss/debate the features of next generation LC/MS focusing on the following three questions: (1) What would the next generation LC/MS look like? (2) How would it change the way we do analysis? and (3) What fundamental issues need to be resolved? A real-world case in the biopharmaceutical industry was presented by Hongying Gao on the needs by industry for LC/MS innovation and technology advancements. The primary invited speakers were Alexander Makarov (Thermo Fisher Scientific) and Richard (Dick) Smith (Pacific Northwest National Laboratory). The open discussions started with Q&A and comments for Alexander Makarov and Dick Smith, followed by insights and perspectives from members of the audience and other invited presenters who shared their thoughts addressing the above questions.

  12. Safety relief valves according new requirements of EN (PED) versus AD/TRD or ASME

    Energy Technology Data Exchange (ETDEWEB)

    Foellmer, B.; Schnettler, A. [Bopp and Reuther, Mannheim (Germany)

    2004-07-01

    In Europe, only Pressure safety relief valves which conform with the Pressure Equipment Directive (PED) 97/23 EC may be used. They are classified PED Category IV and a Notified Body validates the fulfilment of the PED requirements in accordance with a selected conformity evaluation procedure also drawn from PED. The harmonized standards or other technical reference works are stated in a manufacturer's declaration of conformity, which is supplied with the safety relief valve at delivery. Only this ultimately makes it possible to establish the basis used for CE certification and the certified properties which can be derived there from. The CE symbol in the identification plate alone does not supply sufficient information for this purpose. A comparative assessment of the harmonized EN standards compared against the AD and TRD technical rules in this article discloses differences in the certified properties and the applications for spring-loaded safety relief valves. The ASME code is also included in the assessment, since it plays a significant role at least outside Europe. (orig.)

  13. RXTE/ASM Observations of the 35-day Cycle of Her X-1

    CERN Document Server

    Leahy, A

    1998-01-01

    Her X-1 has been monitored nearly continuously in soft X-rays (2-12 keV) since February 1996 by the ASM on board RXTE. We present analysis of these observations which include 23 contiguous 35-day cycles. We present the best yet average 35-day cycle lightcurve for Her X-1. 35-day lightcurve features such as eclipses and absorption dips, and the alternating occurrence of the Main High and Short High states, are well measured. The occurrence of X-ray eclipse during the Low state is confirmed as is the presence of Main High states that ``turn-on'' sharply at orbital phases 0.23 and 0.68. The Main High state covers 35-day phase 0-0.31 and the Short High state covers phase 0.57-0.79, with phase 0 defined by Main High state turn-on. We find extended ingresses and egresses for the Short High state. Marching pre-eclipse absorption dips progressively become shallower during the Main High state. The marching pre-eclipse dip period is best determined from reanalysis of archival data as 1.651 +/- .002 days if the dip marc...

  14. Unsteady Simulation of an ASME Venturi Flow in a Cross Flow

    Science.gov (United States)

    Bonifacio, Jeremy; Rahai, Hamid

    2010-11-01

    Unsteady numerical simulations of an ASME venturi flow into a cross flow were performed. The velocity ratios between the venturi flow and the free stream were 25, 50, and 75%. Two cases of the venturi with and without a tube extension have been investigated. The tube extension length was approximately 4D (here D is the inner diameter of the venturi's outlet), connecting the venturi to the bottom surface of the numerical wind tunnel. A finite volume approach with the Wilcox K-φ turbulence model were used. Results that include contours of the mean velocity, velocity vector, turbulent kinetic energy, pressure and vortices within the venturi as well as downstream in the interaction region indicate that when the venturi is flushed with the surface, there is evidence of flow separation within the venturi, near the outlet. However, when the tube extension was added, the pressure recovery was sustained and flow separation within the venturi was not present and the characteristics of the flow in the interaction region were similar to the corresponding characteristics of a pipe jet in a cross flow.

  15. ASME B89.4.19 Performance Evaluation Tests and Geometric Misalignments in Laser Trackers

    Directory of Open Access Journals (Sweden)

    Muralikrishnan, Bala

    2009-01-01

    Full Text Available Small and unintended offsets, tilts, and eccentricity of the mechanical and optical components in laser trackers introduce systematic errors in the measured spherical coordinates (angles and range readings and possibly in the calculated lengths of reference artifacts. It is desirable that the tests described in the ASME B89.4.19 Standard [1] be sensitive to these geometric misalignments so that any resulting systematic errors are identified during performance evaluation. In this paper, we present some analysis, using error models and numerical simulation, of the sensitivity of the length measurement system tests and two-face system tests in the B89.4.19 Standard to misalignments in laser trackers. We highlight key attributes of the testing strategy adopted in the Standard and propose new length measurement system tests that demonstrate improved sensitivity to some misalignments. Experimental results with a tracker that is not properly error corrected for the effects of the misalignments validate claims regarding the proposed new length tests.

  16. Modelling waste stabilisation ponds with an extended version of ASM3.

    Science.gov (United States)

    Gehring, T; Silva, J D; Kehl, O; Castilhos, A B; Costa, R H R; Uhlenhut, F; Alex, J; Horn, H; Wichern, M

    2010-01-01

    In this paper an extended version of IWA's Activated Sludge Model No 3 (ASM3) was developed to simulate processes in waste stabilisation ponds (WSP). The model modifications included the integration of algae biomass and gas transfer processes for oxygen, carbon dioxide and ammonia depending on wind velocity and a simple ionic equilibrium. The model was applied to a pilot-scale WSP system operated in the city of Florianópolis (Brazil). The system was used to treat leachate from a municipal waste landfill. Mean influent concentrations to the facultative pond of 1,456 g(COD)/m(3) and 505 g(NH4-N)/m(3) were measured. Experimental results indicated an ammonia nitrogen removal of 89.5% with negligible rates of nitrification but intensive ammonia stripping to the atmosphere. Measured data was used in the simulations to consider the impact of wind velocity on oxygen input of 11.1 to 14.4 g(O2)/(m(2) d) and sun radiation on photosynthesis. Good results for pH and ammonia removal were achieved with mean stripping rates of 18.2 and 4.5 g(N)/(m(2) d) for the facultative and maturation pond respectively. Based on measured chlorophyll a concentrations and depending on light intensity and TSS concentration it was possible to model algae concentrations.

  17. [Management committees in health services: an empirical study].

    Science.gov (United States)

    Cecilio, Luiz Carlos de Oliveira

    2010-03-01

    The aim of the article, based on field data collected from a continuing education program for primary health clinic administrators, was to analyze the functioning of a health service management strategy called "management committees". Different meanings and operational modalities emerged in the committees. Various antimonies appeared in the way the committees operate (autonomy versus heteronomy, reproduction of "instituted" versus "instituting" processes, and communicative versus instrumental reasoning), thus reflecting the level of complexity in this management mechanism. Healthcare provision per se by the clinics only appeared occasionally on the committees' agenda, which mainly focused on administrative issues. The article suggests that further research is needed on the coordinator's involvement in the field of forces constituting the management committee, besides developing pedagogical strategies to support the clinic coordinators and health teams in building the committees. The primary data were submitted to an epistemological discussion anchored in the idea of double hermeneutics, multiple validation of research results, and the relationship between theory and practice.

  18. Statistical re-evaluation of the ASME K{sub IC} and K{sub IR} fracture toughness reference curves

    Energy Technology Data Exchange (ETDEWEB)

    Wallin, K.; Rintamaa, R. [Valtion Teknillinen Tutkimuskeskus, Espoo (Finland)

    1998-11-01

    Historically the ASME reference curves have been treated as representing absolute deterministic lower bound curves of fracture toughness. In reality, this is not the case. They represent only deterministic lower bound curves to a specific set of data, which represent a certain probability range. A recently developed statistical lower bound estimation method called the `Master curve`, has been proposed as a candidate for a new lower bound reference curve concept. From a regulatory point of view, the Master curve is somewhat problematic in that it does not claim to be an absolute deterministic lower bound, but corresponds to a specific theoretical failure probability that can be chosen freely based on application. In order to be able to substitute the old ASME reference curves with lower bound curves based on the master curve concept, the inherent statistical nature (and confidence level) of the ASME reference curves must be revealed. In order to estimate the true inherent level of safety, represented by the reference curves, the original data base was re-evaluated with statistical methods and compared to an analysis based on the master curve concept. The analysis reveals that the 5% lower bound Master curve has the same inherent degree of safety as originally intended for the K{sub IC}-reference curve. Similarly, the 1% lower bound Master curve corresponds to the K{sub IR}-reference curve. (orig.)

  19. Denitrification activity of the bacterium Pseudomonas sp. ASM-2-3 isolated from the Ariake Sea tideland.

    Science.gov (United States)

    Kariminiaae-Hamedaani, Hamid-Reza; Kanda, Kohzo; Kato, Fumio

    2004-01-01

    A new denitrifying bacterium strain ASM-2-3 was isolated from the Ariake Sea tideland, Japan. The isolate had the capability to fully remove as high as 225.8 mg nitrate-nitrogen.l(-1) under stationary culture conditions without accumulation of nitrite as an intermediate. From biochemical tests and 16S rDNA sequencing analysis, the genus of the bacterium was identified as Pseudomonas and close to stutzeri species. The nitrate removal efficiency of the isolate was faster than that of the control strain Pseudomonas stutzeri NBRC 14165, using succinate as the sole carbon source. The isolate could grow in up to 10% (w/v) of NaCl containing medium. The enzymatic tests showed that the activity of enzymes responsible for the reduction of nitrate and nitrite in strain ASM-2-3 was 1.4 and 2.3 times higher than that of the control strain. The feasibility of application of the isolate strain ASM-2-3 in a packed bed bioreactor was investigated for 40 d.

  20. Dos esquemas terapéuticos en el manejo de crisis asmática en niños.

    Directory of Open Access Journals (Sweden)

    José Velasco

    1997-01-01

    Full Text Available Objetivo: Comparar los efectos terapéuticos y colaterales de dos esquemas de tratamiento en la crisis asmática: la asociación de fenoterol 100 ug en microdosificador inhalatorio (MDI con aerocámara más dexametasona endovenosa vs salbutamol 100 ug en MDI con aerocámara más hidrocortisona endovenosa. Materiales y métodos: En un estudio prospectivo, randomizado, multicéntrico y abierto, se incluyó 60 niños con crisis asmática leve-moderada (30 para cada grupo. Ambos grupos fueron comparables al ingreso. Resultados: En la evolución no hubo diferencia significativa en la frecuencia respiratoria, puntaje clínico, pico respiratorio forzado (PEF y tremor (p>0.05, hallándose mayor taquicardia en los primeros 30 y 60 minutos en el grupo que recibió Fenoterol - Dexametasona. No se encontró diferencia significativa en la proporción de altas al final del estudio. Conclusiones: Se concluye que la asociación Fenoterol - Dexametasona y Salbutamol - Hidrocortisona son igualmente efectivas en el manejo de la crisis asmática leve - moderada en niños (Ref Med Hered 1997; 8: 5-10

  1. 46 CFR 56.60-1 - Acceptable materials and specifications (replaces 123 and Table 126.1 in ASME B31.1).

    Science.gov (United States)

    2010-10-01

    ... Supports—Materials, Design and Manufacture. SP-61 Pressure Testing of Steel Valves. SP-67 Butterfly Valves... Limited to pipe fittings and valves. See 46 CFR 56.60-15(d) for additional information. Table 56.60-1(b... Buttwelding Fittings. ASME B16.10 2000 Face-to-Face and End-to-End Dimensions of Valves. ASME B16.11...

  2. Función adrenal y metabolismo lipídico en niños asmáticos tratados con budesonida

    Directory of Open Access Journals (Sweden)

    Paoli-de Valeri Mariela

    1999-01-01

    Full Text Available Objetivo. Evaluar el efecto de bajas dosis de budesonida inhalado sobre la función adrenal y el metabolismo lipídico en niños asmáticos. Material y métodos. Se estudiaron: 10 niños asmáticos (edad promedio, 8.6 años tratados con budesonida inhalado (200-300 µg/día por un lapso mayor a tres meses (grupo A; 15 niños asmáticos (edad promedio, 7.8 años sin tratamiento esteroideo (grupo B, y 10 niños no asmáticos (grupo C. Se determinaron los niveles de cortisol basal y postestímulo con ACTH, andrógenos adrenales, lípidos y cortisol urinario. Resultados. Entre los grupos A y B no hubo diferencias significativas en las variables estudiadas. En los niños asmáticos (grupo A-B el cortisol urinario fue significativamente mayor en relación con el grupo C. Los niveles de triglicéridos, colesterol total, colesterol de la lipoproteína de baja densidad e índices aterogénicos fueron mayores en el grupo de niños asmáticos, con y sin budesonida, comparados con el grupo C. Conclusiones. El tratamiento con dosis bajas de budesonida inhalado en niños asmáticos no modificó la función del eje adrenal ni el metabolismo lipídico. Los pacientes asmáticos presentaron un perfil lipídico aterogénico que podría incrementar el riesgo de enfermedad cardiovascular.

  3. [Ethics committees in the experience of the IMSS: a Latin American instance].

    Science.gov (United States)

    Valdez-Martínez, Edith; Mata-Valderrama, Guadalupe; Bedolla, Miguel; Fajardo-Dolci, Germán Enrique

    2015-01-01

    The aim of this article is to identify the current state of hospital bioethics committees and local research ethics committees of the Mexican Institute of Social Security (IMSS). A descriptive cross-sectional study was performed that included all hospitals of the IMSS (N = 262). Two self-administered questionnaires were e-mailed between october and november 2014 to the hospital directors: one for hospital bioethics committees and another for local research ethics committees. Both questionnaires had five sections: committee location, date of committee set up, activity situation, composition, functions, and experience. The response rate was 85 %. It was reported 150 active hospital bioethics committees and 67 active local research ethics committees. In both groups physicians and executive directors dominated committees' membership, and lay people were reported only in seven hospital bioethics committees. The primary function of hospital bioethics committees was case consultation, and their primary goal "to improve the quality of medical care". Local Research Ethics Committees reported as primary function "to evaluate health research protocols and rule of them", and as their primary goal "to protect the rights and wellbeing of the research subjects". Both groups of committees ought to be assessed regularly through audit cycles in order to identify the educative actions that enhance their efficiency.

  4. Hearings Before the Subcommittee on Advanced Research and Technology of the Committee on Science and Astronautics. U.S. House of Representatives, Ninety-First Congress, First Session

    Science.gov (United States)

    1969-12-11

    development group. Nor are we an inspector general who grades the work of others. I do believe. though, that one of our chief responsibilities is the...10M.’s %-d beyond. The Committee concluded that it will lie.-. iy, to upgrade the semiautomatic national airspace system (NAS) now being designed to...year life from the time we get the whole system installed. So I’think we have got a lot of homework to do in technology in order to make the system

  5. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2010-01-01

    Main issues examined at the meeting of 2 October 2009 The October 2009 meeting of the Standing Concertation Committee was entirely devoted to preparation of TREF’s meeting on 21-22 October. The Committee took note of, discussed and agreed on clarifications needed to some of the documents and presentations that the Management intended to submit and/or present to TREF on the following subjects: Equal opportunities The Committee took note of a preliminary report on equal opportunities at CERN drawn up by D. Chromek-Burckhart, the Equal Opportunities Officer, and T. Smith, Chairman of the Equal Opportunities Advisory Panel, containing in particular a proposal for a new process for resolving harassment conflicts. Technical analysis of the CERN Health Insurance Scheme - Actuary’s Report The Committee took note of a presentation by P. Charpentier, Chairman of the CERN Health Insurance Supervisory Board (CHIS Board), on the 2009 actuarial report on the CERN Health Insurance Scheme (CHIS). Th...

  6. The Chinese Olympic Committee

    Institute of Scientific and Technical Information of China (English)

    余信波

    2008-01-01

    The Chinese Olympic Committee (COC) is a non-governmental,non-profit national sports organization of a mass character,with the objective of developing sports and promoting the Olympic Movement in the country.

  7. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2008-01-01

    ORDINARY MEETING ON 27 FEBRUARY 2008 The main items discussed at the meetings of the Standing Concertation Committee on 27 February 2008 included: Short-term Saved Leave Scheme The Committee noted that, by the end of February 2008, some 600 staff had enrolled in the short-term saved leave scheme: approx. 58% had signed up for 1 slice, 14% for two slices, 5% for three slices and 23% for four slices. Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme The Committee agreed to recommend the Director-General to approve Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme. Administrative Circular No. 30 (Rev. 2) - Financial benefits upon taking up appointment and termination of contract The Committee agreed to recommend the Director-General to approve Administrative Circular No. 30 (Rev. 2) - Financial Benefits upon taking up appointment and termination of contract. Progressive Retirement Programme The Progressive Retirement Programme (PR...

  8. 75 FR 34418 - Notice of the Specialty Crop Committee's Stakeholder Listening Session

    Science.gov (United States)

    2010-06-17

    ...; ] DEPARTMENT OF AGRICULTURE Office of the Secretary Notice of the Specialty Crop Committee's Stakeholder Listening Session AGENCY: Research, Education, and Economics, USDA. ACTION: Notice of stakeholder listening session. SUMMARY: The notice announces the Specialty Crop Committee's Stakeholder Listening Session....

  9. Complicated Relationships among Audit Committee Independence, Nonfinancial and Financial Performance

    Directory of Open Access Journals (Sweden)

    David Han-Min Wang

    2013-10-01

    Full Text Available The relationships among the audit committee independence, nonfinancial performance and financial performance are quite complicated. They are not simply bivariate correlations. Rather, there may be mediating effects or moderating influences on these casual associations. Nonetheless, previous research has not investigated these complicated relationships. This paper seeks to examine the mediating impact of nonfinancial performance on the association between the audit committee independence and financial performance. Further, it also explores the moderating role of the audit committee independence in the influence of nonfinancial performance on financial performance. The findings imply that nonfinancial performance interferes with the effect of the audit committee independence on financial performance, in which it lessens this effect. The empirical results also suggest that the audit committee independence plays the moderating role in the relationship between nonfinancial performance and financial performance, in which the independence of the audit committee is positively related to this relationship.

  10. Fusion Energy Sciences Advisory Committee Reports on Review of the Fusion Materials Research Program, Review of the Proposed Proof-of-Principle Programs, Review of the Possible Pathways for Pursuing Burning Plasma Physics, and Comments on the ER Facilities Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1998-07-01

    The Fusion Energy Science Advisory Committee was asked to conduct a review of Fusion Materials Research Program (the Structural Materials portion of the Fusion Program) by Dr. Martha Krebs, Director of Energy Research for the Department of Energy. This request was motivated by the fact that significant changes have been made in the overall direction of the Fusion Program from one primarily focused on the milestones necessary to the construction of successively larger machines to one where the necessary scientific basis for an attractive fusion energy system is. better understood. It was in this context that the review of current scientific excellence and recommendations for future goals and balance within the Program was requested.

  11. [From Nuremberg to the ethics committees in human experimentation].

    Science.gov (United States)

    Demarez, Jean-Paul

    2008-02-01

    During the Nuremberg trials, the accusation prompted the creation of an ad hoc committee to advise on human experiments carried out on prisoners during wartime in the USA. Precisely a charge that had been brought against Karl Brandt and his colleagues. This committee was the forerunner of the Independent Committees, to which the Declaration of Helsinki assigned a role in analysing the ethics of research projects in humans. From 1980 onwards, in industrialised countries, the legislation regarding clinical trials began to incorporate similar structures, IRBs in the United States of America, Ethics Committees elsewhere, and the ''Committee for the Protection of Persons" in France. However, at that time, in spite of the misleading words, we went from ethics to law, from rules of conduct intended for researchers to legal regulations organising relations between sponsors, investigators and persons participating in biomedical research, which is not the same thing.

  12. 76 FR 18713 - Committees on Rulemaking, Regulation, and Adjudication

    Science.gov (United States)

    2011-04-05

    ... Assembly of the Administrative Conference of the United States (ACUS). Each committee will meet to discuss... ``Research'' section of the ACUS Web site, at http://www.acus.gov . Comments may be submitted by e-mail to Comments@acus.gov , with the name of the relevant committee in the subject line, or by postal mail...

  13. Occupational Safety and Health Administration (OSHA) Technical Support Committee

    Science.gov (United States)

    2000-12-29

    0575 N5-95-1 Occupational Safety & Health Administration (OSHA) Technical Support Committee U.S. DEPARTMENT OF THE NAVY CARDEROCK DIVISION, NAVAL...4. TITLE AND SUBTITLE The National Shipbuilding Research Program, Occupational Safety & Health Administration (OSHA) Technical Support...SPECIFICALLY DISCLAIMED. Sp-5 Safety and Health Final Report Occupational Safety & Health Administration (OSHA) Technical Support Committee Task No

  14. Updating of ASME Nuclear Code Case N-201 to Accommodate the Needs of Metallic Core Support Structures for High Temperature Gas Cooled Reactors Currently in Development

    Energy Technology Data Exchange (ETDEWEB)

    Mit Basol; John F. Kielb; John F. MuHooly; Kobus Smit

    2007-05-02

    On September 29, 2005, ASME Standards Technology, LLC (ASME ST-LLC) executed a multi-year, cooperative agreement with the United States DOE for the Generation IV Reactor Materials project. The project's objective is to update and expand appropriate materials, construction, and design codes for application in future Generation IV nuclear reactor systems that operate at elevated temperatures. Task 4 was embarked upon in recognition of the large quantity of ongoing reactor designs utilizing high temperature technology. Since Code Case N-201 had not seen a significant revision (except for a minor revision in September, 2006 to change the SA-336 forging reference for 304SS and 316SS to SA-965 in Tables 1.2(a) and 1.2(b), and some minor editorial changes) since December 1994, identifying recommended updates to support the current high temperature Core Support Structure (CSS) designs and potential new designs was important. As anticipated, the Task 4 effort identified a number of Code Case N-201 issues. Items requiring further consideration range from addressing apparent inconsistencies in definitions and certain material properties between CC-N-201 and Subsection NH, to inclusion of additional materials to provide the designer more flexibility of design. Task 4 developed a design parameter survey that requested input from the CSS designers of ongoing high temperature gas cooled reactor metallic core support designs. The responses to the survey provided Task 4 valuable input to identify the design operating parameters and future needs of the CSS designers. Types of materials, metal temperature, time of exposure, design pressure, design life, and fluence levels were included in the Task 4 survey responses. The results of the survey are included in this report. This research proves that additional work must be done to update Code Case N-201. Task 4 activities provide the framework for the Code Case N-201 update and future work to provide input on materials. Candidate

  15. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2009-01-01

    Main points examined at the meeting of 24 June 2009 Results of the 2009 MARS exercise The Committee took note of the results of the 2009 MARS exercise presented by the Head of the HR Department, expressing satisfaction for the early availability of the statistics and for the fact that the analysis of the results covered the last three years. Status report on the work on the five-yearly review The Committee took note of a presentation by P. Gildemyn on the data collection procedure for the 2010 five-yearly review (staff, fellows, associate members of the personnel, CHIS) and of the proposed work schedule. Implications for employment conditions of the discussions at the Finance Committee and Council on 17 and 18 June 2009 The Chairman briefly reported on the discussions at the meetings of the Finance Committee and Council in June 2009, on the 2010-2014 medium-term plan and the 2010 preliminary draft budget, as well as on the modified strategy and goals for 2009. The Committee ...

  16. Accreditation of ethics committees: experience of an ethics committee.

    Science.gov (United States)

    Kulkarni, Ragini; Saraiya, Usha

    2015-01-01

    Many ethics committees (ECs) approving clinical trials in India have got themselves registered with the Drugs Controller General of India as per regulatory requirements. However, there is still scope to improve their functioning. Accreditation, which entails adherence to national and international standards, helps an EC to protect the rights, safety and well-being of research participants. The National Institute for Research in Reproductive Health (NIRRH) ethics committee for clinical studies has received recognition, or accreditation, from the Strategic Initiative for Developing Capacity in Ethical Review (SIDCER). An EC receives recognition from SIDCER if it meets five standards related to its structure and composition; adherence to specific policies; completeness of the review process; after-review process; and documentation and archiving. The extent to which these standards have been met is assessed in various ways, such as review of the EC's records, interviews of selected EC members and observation of a full board meeting of the EC. This paper describes the experiences of the NIRRH EC during and after the process of receiving recognition.

  17. Towards a consensus-based biokinetic model for green microalgae - The ASM-A.

    Science.gov (United States)

    Wágner, Dorottya S; Valverde-Pérez, Borja; Sæbø, Mariann; Bregua de la Sotilla, Marta; Van Wagenen, Jonathan; Smets, Barth F; Plósz, Benedek Gy

    2016-10-15

    Cultivation of microalgae in open ponds and closed photobioreactors (PBRs) using wastewater resources offers an opportunity for biochemical nutrient recovery. Effective reactor system design and process control of PBRs requires process models. Several models with different complexities have been developed to predict microalgal growth. However, none of these models can effectively describe all the relevant processes when microalgal growth is coupled with nutrient removal and recovery from wastewaters. Here, we present a mathematical model developed to simulate green microalgal growth (ASM-A) using the systematic approach of the activated sludge modelling (ASM) framework. The process model - identified based on a literature review and using new experimental data - accounts for factors influencing photoautotrophic and heterotrophic microalgal growth, nutrient uptake and storage (i.e. Droop model) and decay of microalgae. Model parameters were estimated using laboratory-scale batch and sequenced batch experiments using the novel Latin Hypercube Sampling based Simplex (LHSS) method. The model was evaluated using independent data obtained in a 24-L PBR operated in sequenced batch mode. Identifiability of the model was assessed. The model can effectively describe microalgal biomass growth, ammonia and phosphate concentrations as well as the phosphorus storage using a set of average parameter values estimated with the experimental data. A statistical analysis of simulation and measured data suggests that culture history and substrate availability can introduce significant variability on parameter values for predicting the reaction rates for bulk nitrate and the intracellularly stored nitrogen state-variables, thereby requiring scenario specific model calibration. ASM-A was identified using standard cultivation medium and it can provide a platform for extensions accounting for factors influencing algal growth and nutrient storage using wastewater resources.

  18. Final Progress Report for the activity called AMO2010 committee

    Energy Technology Data Exchange (ETDEWEB)

    Donald Shapero; Michael Moloney

    2006-12-31

    The committee was charged to produce a comprehensive report on the status of AMO Science. The committee was charged to produce a report that: 1. Reviewed the field of AMO science, emphasize recent accomplishments, and identify new opportunities and compelling scientific questions; 2. Identified the impact of AMO science on other scientific fields, emerging technologies, and national needs; 3. Identified future workforce, societal and educational needs for AMO science; and 4. Made recommendations on how the US research enterprise might realize the full potential of AMO science. The committee also produced an intermediate report addressing key research issues and themes facing the research community.

  19. Audit committees: practices, practitioners and praxis of governance

    OpenAIRE

    Brennan, Niamh; Kirwan, Collette E.

    2015-01-01

    Purpose: The purpose of this paper is to review and critique prior research on audit committees using a practice-theory lens. Research on audit committees has followed the same trajectory as early research on boards of directors, which has been criticised for its singular theoretical perspectives and methodologies that do not capture the complexity of real-world experiences/behaviours. Design/methodology/approach: The authors devise an analytical framework based on practice theory to conduct ...

  20. [Hospital clinical ethics committees].

    Science.gov (United States)

    Gómez Velásquez, Luis; Gómez Espinosa, Luis Néstor

    2007-01-01

    The scientific and technological advances have been surprising, more in the two last decades, but they don't go united with to the ethical values of the medical professional practice, it has been totally escaped, specially when the biological subsistence, the maintenance of the life through apparatuses and the mechanisms that prolong the existence are who undergoes an alteration that until recently time was mortal shortly lapse. It is common listening that exist a crisis in the medical profession, but what really is it of human values, which as soon and taken into nowadays, actually professional account, which gives rise to a dehumanization towards the life, the health, the disease, the suffering and the death. The ideal of the doctor to give to service to the man in its life and health, as well to be conscious that the last biological process that must fulfill is the death, and when it appears, does not have considered as a actually professional failure. It has protect to the patient as the extreme cruelty therapeutic, that it has right a worthy death. It's taking to the birth of the hospital ethics committees, they have like function to analyze, to advise and to think about the ethical dilemmas that appear actually clinical or in the biomedical investigation. In 1982 in the UEA only 1% of its hospitals had a ethics committees; by 1988, it was 67% and the 100% in 2000. In Mexico the process of the formation by these committees begins, only in the Military Central Hospital, to count the ethics committee on 1983, also the Hospital no. 14 of the IMSS in Guadalajara, it works with regularity from 1995, with internal teaching of bioethic. The Secretariat of Health has asked the formation of the bioethical committees in each hospital, and order the it was be coordinated by the National Committee of Bioética. The integration of these committees is indispensable that their members have the knowledge necessary of bioética. The Mexican Society of Ortopedia, conscious of

  1. Acid sphingomyelinase (Asm) deficiency patients in The Netherlands and Belgium: disease spectrum and natural course in attenuated patients.

    Science.gov (United States)

    Hollak, C E M; de Sonnaville, E S V; Cassiman, D; Linthorst, G E; Groener, J E; Morava, E; Wevers, R A; Mannens, M; Aerts, J M F G; Meersseman, W; Akkerman, E; Niezen-Koning, K E; Mulder, M F; Visser, G; Wijburg, F A; Lefeber, D; Poorthuis, B J H M

    2012-11-01

    Niemann-Pick disease (NPD) is a neurovisceral lysosomal storage disorder caused by acid sphingomyelinase (ASM) deficiency, which can be categorized as either Niemann-Pick disease type A [NPD-A], with progressive neurological disease and death in early childhood, or as Niemann-Pick disease type B [NPD-B], with a more variable spectrum of manifestations. Enzyme replacement therapy (ERT) with recombinant sphingomyelinase is currently studied as potential treatment for NPD-B patients. The objective of this study is to characterize the clinical features of patients with ASM deficiency in the Netherlands and Belgium with focus on the natural disease course of NPD-B patients. Prospective and retrospective data on ASM deficient patients were collected in The Netherlands and part of Belgium. Patients with NPD-B that could be followed prospectively were evaluated every 6-12 months for pulmonary function tests, 6 minute walk test (6 MWT), imaging (bone marrow infiltration measured by QCSI, organ volumes by MRI and CT scan of the lungs) and biochemical markers. Twenty-five patients with ASM deficiency were identified (13 males, 12 females, median age 13years, range 1-59 years). Nine patients had died at the time of the study, including four NPD-A patients at the age of 1,1, 2, 3 and five NPDB patents at the age of 5, 6, 43, 56 and 60 years. There was a high prevalence of homozygosity and compound heterozygosity for the common p.Arg608del mutation in 43% and 19% of NPD-B patients, respectively. In NPD-B patients, thrombocytopenia was present in most, while anemia and leucopenia were less common (33% and 6 % respectively). HDL cholesterol was reduced in most patients. Pulmonary disease was severe in several patients. Follow-up up to 11 years revealed a gradual decrease in platelet count. Detailed investigations in 6 NPD-B patients with follow-up in 4 patients revealed remarkable stable disease parameters up to 6 years, with some decline in pulmonary function and 6 MWT. Bone

  2. 改进的ASM面部特征点定位算法%Improved ASM Algorithm for Facial Feature Location

    Institute of Scientific and Technical Information of China (English)

    刘姗姗

    2013-01-01

    为了提高主动形状模型(ASM)算法的性能,提出了从ASM模型的初始位置、人脸特征点局部搜索两方面改进的叠加ASM模型及局部特征点搜索的二维轮廓线算法.实验结果表明,该算法比传统的ASM对人脸面部特征点定位有更高的精确度.

  3. 77 FR 38768 - Smart Grid Advisory Committee

    Science.gov (United States)

    2012-06-29

    ... National Institute of Standards and Technology Smart Grid Advisory Committee AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Smart Grid... the Smart Grid Interoperability Panel transition plan, review the status of the research subcommittee...

  4. Energy Materials Coordinating Committee (EMaCC)

    Energy Technology Data Exchange (ETDEWEB)

    1991-05-31

    This report summarizes EMaCC activities for fiscal year 1990 and describes the materials research programs of various offices and divisions within the department. The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further the effective use of materials expertise within the department. (JL)

  5. Assays for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration.

    Science.gov (United States)

    Goncharova, Elena A; Goncharov, Dmitry A; Krymskaya, Vera P

    2006-01-01

    Migration of human pulmonary vascular smooth muscle (VSM) cells contributes to vascular remodeling in pulmonary arterial hypertension and atherosclerosis. Evidence also indicates that, in part, migration of airway smooth muscle (ASM) cells may contribute to airway remodeling associated with asthma. Here we describe migration of VSM and ASM cells in vitro using Transwell or Boyden chamber assays. Because dissecting signaling mechanisms regulating cell migration requires molecular approaches, our protocol also describes how to assess migration of transfected VSM and ASM cells. Transwell or Boyden chamber assays can be completed in approximately 8 h and include plating of serum-deprived VSM or ASM cell suspension on membrane precoated with collagen, migration of cells toward chemotactic gradient and visual (Transwell) or digital (Boyden chamber) analysis of membrane. Although the Transwell assay is easy, the Boyden chamber assay requires hands-on experience; however, both assays are reliable cell-based approaches providing valuable information on how chemotactic and inflammatory factors modulate VSM and ASM migration.

  6. Committee on Atomic, Molecular and Optical Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Lancaster, James [National Academy of Sciences, Washington, DC (United States)

    2015-06-30

    The Committee on Atomic, Molecular, and Optical Sciences (CAMOS) is a standing activity of the National Research Council (NRC) that operates under the auspices of the Board on Physics and Astronomy. CAMOS is one of five standing committees of the BPA that are charged with assisting it in achieving its goals—monitoring the health of physics and astronomy, identifying important new developments at the scientific forefronts, fostering interactions with other fields, strengthening connections to technology, facilitating effective service to the nation, and enhancing education in physics. CAMOS provides these capabilities for the atomic, molecular and optical (AMO) sciences.

  7. 78 FR 69991 - Advisory Committee; Veterinary Medicine Advisory Committee; Termination

    Science.gov (United States)

    2013-11-22

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 14 Advisory Committee; Veterinary Medicine... Food and Drug Administration (FDA) is announcing the termination of the Veterinary Medicine Advisory Committee. This document removes the Veterinary Advisory Committee from the Agency's list of...

  8. 75 FR 63888 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-10-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... regarding piracy --Matters arising from the 25th extraordinary and the 104th regular sessions of the...

  9. 76 FR 12787 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-03-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... piracy; --Matters arising from the 105th regular session of the IMO Council; --Technical...

  10. 77 FR 12353 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-02-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... Convention, 2006; Fair treatment of seafarers in the event of a maritime accident; Piracy; Matters...

  11. 78 FR 17467 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-03-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... seafarers in the event of a maritime accident. --Piracy. --Collation and preservation of evidence...

  12. 77 FR 21619 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-04-10

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will... implementation of new measures; Role of the human element; Formal safety assessment; Piracy and armed...

  13. Scope and implementation of standards ASME N510 / N511 in air treatment system (HVAC) of the Asco nuclear power plant; Alcance e implementacion de las normas ASME N511 en el sistema de tratamiento de aire (HVAC) de la central nuclear de Asco

    Energy Technology Data Exchange (ETDEWEB)

    Jaimot Jimenez, J. J.

    2013-07-01

    With the ITC for renewal of license units 1 and 2 of Asco, the CSN It required the commissioning tests underway in the air, according to ASME N510 filter units. It is required that, for safety-related units, to undertake preventive inspections according to ASME N511. All these requirements, in tight deadlines, have represented a great challenge for the organizations of maintenance and engineering of ANAV.

  14. 78 FR 7387 - Advisory Committee on Biotechnology and 21st Century Agriculture; Renewal

    Science.gov (United States)

    2013-02-01

    ...; ] DEPARTMENT OF AGRICULTURE Advisory Committee on Biotechnology and 21st Century Agriculture; Renewal AGENCY: Agricultural Research Service, USDA. ACTION: Advisory Committee on Biotechnology and 21st Century Agriculture... Committee on Biotechnology and 21st Century Agriculture (AC21). The Secretary of Agriculture has...

  15. 77 FR 63840 - Cellular, Tissue and Gene Therapies Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-10-17

    ... HUMAN SERVICES Food and Drug Administration Cellular, Tissue and Gene Therapies Advisory Committee..., Tissue and Gene Therapies Advisory Committee. General Function of the Committee: To provide advice and..., Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, and...

  16. 78 FR 79699 - Cellular, Tissue, and Gene Therapies Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-12-31

    ... No. FDA-2013-N-0001] Cellular, Tissue, and Gene Therapies Advisory Committee; Notice of Meeting... the public. Name of Committee: Cellular, Tissue, and Gene Therapies Advisory Committee. General..., Tissue, and Gene Therapies, Center for Biologics Evaluation and Research (CBER), FDA. On February...

  17. 76 FR 81513 - Cellular, Tissue, and Gene Therapies Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-12-28

    ... HUMAN SERVICES Food and Drug Administration Cellular, Tissue, and Gene Therapies Advisory Committee..., Tissue, and Gene Therapies Advisory Committee. General Function of the Committee: To provide advice and... Gene Therapies, Center for Biologics Evaluation and Research, FDA. FDA intends to make...

  18. CCCT - Patient Advocate Steering Committee

    Science.gov (United States)

    The Patient Advocate Steering Committee (PASC) works to ensure advocates involved with the Scientific Steering Committees (SSCs) are completely integrated in the development, implementation, and monitoring of clinical trials within those groups.

  19. 76 FR 56454 - Consumer Advisory Committee Meeting

    Science.gov (United States)

    2011-09-13

    ... COMMISSION Consumer Advisory Committee Meeting AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (Committee). The purpose of the Committee is to make recommendations to the Commission regarding...

  20. 75 FR 9898 - Consumer Advisory Committee

    Science.gov (United States)

    2010-03-04

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (``Committee''). The purpose of the ] Committee is to make recommendations to the Commission regarding...

  1. 75 FR 4819 - Consumer Advisory Committee

    Science.gov (United States)

    2010-01-29

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding...

  2. The European Mathematical Society Ethics Committee

    DEFF Research Database (Denmark)

    Jensen, Arne

    2011-01-01

    The Executive Committee of the European Mathematical Society created an Ethics Committee in the Spring of 2010.......The Executive Committee of the European Mathematical Society created an Ethics Committee in the Spring of 2010....

  3. SENIOR STAFF ADVANCEMENT COMMITTEE (SSAC)

    CERN Document Server

    2000-01-01

    Composition and mandateThe Senior Staff Advancement Committee is composed of members nominated ad persona by the Director-General.The Committee examines proposals from Divisions concerning promotions to grade 13 in Career Path IX, changes of career path to Career Path IX and advancements to the exceptional grade in Career path VIII.The Director-General may consult the Committee on any matter related to senior staff careers.The Committee makes its recommendations to the Director-General.

  4. Citizens Advisory Committees.

    Science.gov (United States)

    Stemnock, Suzanne K.

    1968-01-01

    This document contains the results of a national survey designed to determine the composition and location of permanent citizens advisory committees operating within the nation's school districts. The 52 district-wide, continuing citizens advisory bodies identified by 290 responding school systems are listed alphabetically by State. The following…

  5. Module utilization committee

    Science.gov (United States)

    Volkmer, K.; Praver, G.

    1984-01-01

    Photovoltaic collector modules were declared surplus to the needs of the U.S. Dept. of Energy. The Module Utilization Committee was formed to make appropriate disposition of the surplus modules on a national basis and to act as a broker for requests for these modules originating outside of the National Photovoltaics Program.

  6. Solid state sciences committee forum

    Science.gov (United States)

    Smith, Philip

    1992-05-01

    The 1991 SSSC Forum was conducted under the auspices of the Board on Physics and Astronomy's Solid State Sciences Committee (SSSC) and cosponsored with the National Materials Advisory Board (NMAB). The Forum was the culmination of a year-long dissemination effort following up the NCR study Materials Science and Engineering for the 1990s that was released in September of 1989 and successfully brought together experts and policy makers in the field of advanced materials processing to discuss issues pertinent to the field. Support for the Forum was provided by the Air Force office of Scientific Research (AFOSR), the Department of Energy (DOE), the National Science Foundation (NSF), and the office of Naval Research (ONR).

  7. Module Utilization Committee. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1984-03-01

    Photovoltaic collector modules were declared surplus to the needs of the US Department of Energy. The Module Utilization Committee was formed to make appropriate disposition of the surplus modules. The final report of that committee accounts for that disposition. The membership and activities of the committee are set forth and the results of its activities are reported.

  8. Scholarship Committees--Their Duties

    Science.gov (United States)

    Fletcher, Oscar J.

    1978-01-01

    Some functions for members of a scholarship committee are presented along with a suggested technique for committee operation and examples of problems handled by members of such a committee at the College of Veterinary Medicine at the University of Georgia. (LBH)

  9. Comparative studies on the effects of a yucca extract and acibenzolar-S-methyl (ASM) on inhibition of Venturia inaequalis in apple leaves

    DEFF Research Database (Denmark)

    Bengtsson, Marianne Vibeke; Wulff, Ednar Gadelha; Jørgensen, Hans Jørgen Lyngs;

    2009-01-01

    The effect of an extract of Yucca schidigera on the control and infection process of the apple scab pathogen, Venturia inaequalis, was examined and compared with the chemical resistance inducer, acibenzolar-S-methyl (ASM). In seedling assays, both materials significantly reduced apple scab symptoms...... and pathogen sporulation on leaves and both showed similar control efficacies as the reference treatment, sulphur. Whereas yucca extract and sulphur gave significant inhibition of conidial germination in vitro, ASM did not inhibit germination. Histopathological studies of the infection process of V. inaequalis...... in apple leaves showed that the yucca extract primarily acted by inhibiting pre-penetration events and penetration itself. In contrast, the ASM treatment significantly inhibited more stages of the infection process (pre-penetration, penetration and post-penetration events). These observations suggest...

  10. Intervención educativa para población infanto-juvenil asmática

    Directory of Open Access Journals (Sweden)

    Maria Antonia Acevedo Veja

    2015-11-01

    Full Text Available Se realizó una intervención educativa a la población infanto-juvenil asmática con edades entre ocho y once años en el policlínico de Manatí, Las Tunas, entre enero y julio de 2012, con el objetivo de evaluar la eficacia de la misma. La población de estudio estuvo formada por los 258 pacientes asmáticos de los 29 Consultorios de Médico de Familia (CMF del área, y la muestra por los 50 seleccionados por muestreo aleatorio simple. La información se obtuvo mediante un cuestionario que fue aplicado antes y después de la intervención educativa y los datos fueron recogidos durante la consulta y de la historia clínica individual. Se concluyó que predominó el sexo masculino, con antecedentes de primera línea de asma bronquial, con factores desencadenantes tales como: infecciones respiratorias agudas, polvo y humedad, así como aquellos que presentan signos clínicos de reflujo y que tienen una mala técnica de aplicación de spray. Se apreció un insuficiente nivel de conocimientos sobre la evaluación de severidad de la crisis, los factores desencadenantes, el manejo del spray y el tratamiento intercrisis, y las exacerbaciones.

  11. Alteraciones espirométricas en pacientes asmáticos del municipio Majibacoa, 2009-2013

    Directory of Open Access Journals (Sweden)

    Mailin Molina Leyva

    2014-08-01

    Full Text Available Se realizó un estudio descriptivo, con el objetivo de identificar alteraciones espirométricas en pacientes asmáticos del municipio Majibacoa, en el período comprendido desde enero del 2009 a enero del 2013. La muestra se integró por cincuenta pacientes asmáticos con más de 20 años de evolución de la enfermedad. Se les realizó previo consentimiento informado y una prueba espirométrica. Predominó el sexo femenino y las edades comprendidas entre 35 y 54 años. Prevalecieron los pacientes en la categoría de asma persistente severa. El volumen espiratorio forzado del primer segundo se comportó patológico en el mayor por ciento de los pacientes y la capacidad vital forzada mostró alteración en un menor número de pacientes. El patrón espirométrico obstructivo fue el más frecuente en los pacientes estudiados

  12. Influencia de tres tratamientos psicológicos sobre dimensiones de personalidad en niños asmáticos

    OpenAIRE

    Benedito Monleón, Mari Carmen; Botella Arbona, Cristina; López Andreu, Juan Alonso

    1996-01-01

    El presente trabajo estudia la influencia de tres procedimientos terapéuticos sobre distintas dimensiones de personalidad en niños asmáticos. Se seleccionaron 39 sujetos asmáticos que fueron distribuidos al azar en tres grupos terapéuticos de 13 sujetos cada uno: Relajación, Desensibilización sistemática como técnica de autocontrol e Inoculación de estrés. Antes y después de la aplicación de cada una de las terapias se midieron en los pacientes las dimensiones ...

  13. Eficacia de la suplementación con calcifediol en el control del asma en pacientes asmáticos con déficit de vitamina D

    OpenAIRE

    Salinero González, Lourdes

    2016-01-01

    Introducción: Existen numerosos estudios transversales en niños y adultos que indican que los niveles bajos de vitamina D en los pacientes asmáticos se correlacionan con un peor control, una peor función pulmonar, una disminución de la respuesta a glucocorticoides y más frecuentes exacerbaciones. Por otra parte, existe un grupo importante de pacientes asmáticos que presentan un control insuficiente a pesar de altas dosis de corticoides inhalados, ante lo que se han investigado nuevas alternat...

  14. 19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

  15. The practice of obtaining approval from medical research ethics committees: a comparison within 12 European countries for a descriptive study on acetylcholinesterase inhibitors in Alzheimer's dementia.

    NARCIS (Netherlands)

    Olde Rikkert, M.G.M.; Lauque, S.; Frolich, L.; Vellas, B.; Dekkers, W.J.M.

    2005-01-01

    Across Europe the protection of research subjects with dementia has to meet a variety of national legislation and ethical codes. This research project compared how in different EU countries one single descriptive multinational study on dementia treatment strategies was evaluated by medical ethical

  16. Assessing the effectiveness of a local agricultural research committee in diffusing sustainable cocoa production practices: the case of capsid control in Ghana

    NARCIS (Netherlands)

    Ayenor, G.K.; Röling, N.; Huis, van A.; Padi, B.; Obeng-Ofori, D.

    2007-01-01

    The conventional method of `delivering¿ technologies recommended by researchers to farmers through extension has proved ineffective, resulting in a persistent low (3.5% over ten years) adoption of research-based cocoa technologies. The present study was conducted in the Eastern Region of Ghana and

  17. Judicial Training and Research for Child Custody Litigation. Report To Accompany H.R. 1253. Committee on the Judiciary, House of Representatives, 102d Congress, 2d Session.

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Committee on the Judiciary.

    The purpose of House Resolution (HR) 1253, an amendment to the State Justice Institute (SJI) Act of 1984, is to authorize the SJI to carry out research on state judicial decisions and develop judicial training curricula related to child custody litigation involving domestic violence, and to disseminate the results of this research. The report…

  18. Colleges and Institutes: Advanced Skills and Applied Research. Submission to the House of Commons Standing Committee on Finance Pre-Budget Consultations 2009

    Science.gov (United States)

    Association of Canadian Community Colleges, 2009

    2009-01-01

    Integrated with the industrial and technical drivers of the economy, Canada's colleges, institutes, polytechnics and cegeps offer the advanced skills of faculty and staff to support the private sector's need for applied research, product and process innovation, commercialization and technology transfer. Federal investments in research over the…

  19. The practice of obtaining approval from medical research ethics committees: a comparison within 12 European countries for a descriptive study on acetylcholinesterase inhibitors in Alzheimer's dementia.

    NARCIS (Netherlands)

    Olde Rikkert, M.G.M.; Lauque, S.; Frolich, L.; Vellas, B.; Dekkers, W.J.M.

    2005-01-01

    Across Europe the protection of research subjects with dementia has to meet a variety of national legislation and ethical codes. This research project compared how in different EU countries one single descriptive multinational study on dementia treatment strategies was evaluated by medical ethical c

  20. Committees and sponsors

    Science.gov (United States)

    2011-10-01

    International Advisory Committee Richard F CastenYale, USA Luiz Carlos ChamonSão Paulo, Brazil Osvaldo CivitareseLa Plata, Argentina Jozsef CsehATOMKI, Hungary Jerry P DraayerLSU, USA Alfredo Galindo-UribarriORNL & UT, USA James J KolataNotre Dame, USA Jorge López UTEP, USA Joseph B NatowitzTexas A & M, USA Ma Esther Ortiz IF-UNAM Stuart PittelDelaware, USA Andrés SandovalIF-UNAM Adam SzczepaniakIndiana, USA Piet Van IsackerGANIL, France Michael WiescherNotre Dame, USA Organizing Committee Libertad Barrón-Palos (Chair)IF-UNAM Roelof BijkerICN-UNAM Ruben FossionICN-UNAM David LizcanoININ Sponsors Instituto de Ciencias Nucleares, UNAMInstituto de Física, UNAMInstituto Nacional de Investigaciones NuclearesDivisión de Física Nuclear de la SMFCentro Latinoamericano de Física

  1. Standing Concertation Committee

    CERN Document Server

    HR Department

    2009-01-01

    Ordinary Meeting on 11 May 2009 The meeting of the Standing Concertation Committee held on 11 May 2009 was entirely dedicated to the preparation of the TREF meeting on 19 & 20 May 2009. The Committee took note, discussed and agreed on some clarifications on a number of documents and presentations that the Management planned to submit and/or present to TREF on the following subjects: • Personnel statistics 2008: J. Purvis presented the Personnel Statistics for 2008 prepared by HR Department. In line with the previous year, key messages were firstly, a general reduction in staff (2544 to 2400, - 6%), secondly, a reduction in administrative services personnel (from 422 to 387, - 8%) and thirdly, a marked increase in the number of Users and Unpaid Associates (from 8369 to 9140, + 9%) • Five-Yearly Review 2010: A series of draft documents were submitted for discussion, comprising an introductory document explaining the statutory basis for the following four document...

  2. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2009-01-01

    The main items discussed at the meetings of the Standing Concertation Committee in the first quarter of 2009 included: Merit Appraisal and Recognition Scheme (MARS) 2009 exercise The committee took note of 2009 MARS ceiling guidelines giving the advancement budget by career path and amounting to approx 1.80% of the basic salary bill. To this will be added 250 steps CERN-wide, financed by savings from implementation of the international indemnity for 2007, 2008 and the first half of 2009. The specific Senior Staff Guidelines, including the proposed number of promotions from Career Path E to F, were also noted. The guidelines with respect to step distribution were also noted: the minima and maxima remain the same as in previous years. Compliance with the guidelines will continue to be monitored closely (more details, including a frequently asked questions section). It was also noted that Financial Awards (awards for extraordinary service and responsibility allowances) may b...

  3. Regulatory Review Committee update

    Energy Technology Data Exchange (ETDEWEB)

    Steele, T. [Polishuk, Camman and Steele, London ON (Canada)

    2001-07-01

    The Committee's objectives, current membership and current issues are reviewed. Each current issue, notably the consultation process with the Ministry of Natural Resources, appeal of Ministry actions, orphan wells/security deposits, oilfield fluid disposal and labour code practices review are discussed in some detail. Dissatisfaction with the current appeals process to the Ministry is highlighted, along with a search for an all encompassing solution. The orphan well problem also received considerable attention, with similar demands for a comprehensive solution.

  4. Standing Concertation Committee

    CERN Multimedia

    2007-01-01

    ORDINARY MEETING ON 30 JANUARY 2007 The main items discussed at the meeting of the Standing Concertation Committee on 30 January 2007 included: Administrative Circular No. 26: with the introduction of the merit recognition system in the framework of the 5-yearly review of CERN employment conditions, Administrative Circular No. 26 has been revised. The Committee took note of the revised document which is being finalized for submission to the Director-General for approval in the near future. Technical analysis of CERN Health Insurance Scheme: the Committee was informed that a group has been set up by the Director-General to analyse the financial situation of the CERN Health Insurance Scheme in the short and long term, and to propose measures to ensure that the Scheme remains in financial balance, with adequate cover, over the medium term. The group's terms of reference and membership were communicated. Voluntary programmes It was announced that the programmes: 'part-time work as a pre-retirement mea...

  5. Standing Concertation Committee

    CERN Multimedia

    2007-01-01

    Ordinary meeting on 30 January 2007 The main items discussed at the meeting of the Standing Concertation Committee on 30 January 2007 included: Administrative Circular No. 26: with the introduction of the merit recognition system in the framework of the 5-yearly review of CERN employment conditions, Administrative Circular No. 26 has been revised. The committee took note of the revised document which is being finalized for submission to the Director-General for approval in the near future. Technical analysis of CERN Health Insurance Scheme: the Committee was informed that a group has been set up by the Director-General to analyse the financial situation of the CERN Health Insurance Scheme in the short and long term, and to propose measures to ensure that the Scheme remains in financial balance, with adequate cover, over the medium term. The group's terms of reference and membership were communicated. Voluntary programmes It was announced that the programmes: 'part-time work as a pre-retirement measure...

  6. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2007-01-01

    ORDINARY MEETING ON 27 FEBRUARY 2007 The main items discussed at the meeting of the Standing Concertation Committee on 27 February 2007 included: Saved Leave Scheme (SLS): It was announced that a Management/Staff Association working group had been set up to discuss the Saved Leave Scheme (SLS): Members : M. Büttner, E. Chiaveri (chair), Ph. Defert, D. Klem, M. Vitasse, J.-M. Saint-Viteux. It was noted that the Staff Association was launching a questionnaire on SLS and distributed to all members of the personnel. Merit Recognition Guidelines: In the context of the new Merit Appraisal and Recognition Scheme (MARS), the committee took note of the CERN-wide 2007 Merit Recognition Guidelines, including the Frequently Asked Questions on HR Department's dedicated website. Information on CERN's medium and long-term plans (MTP-LTP)/Contract renewals/ External mobility The Committee took note of the information provided on CERN's MTP-LTP and of documentation distributed at the meeting by the Staff ...

  7. Characteristics of effective health and safety committees: survey results.

    Science.gov (United States)

    Morse, Tim; Bracker, Anne; Warren, Nicholas; Goyzueta, Jeanette; Cook, Matthew

    2013-02-01

    Although perhaps the most common worker-management structure, there has been surprisingly little research on describing and evaluating the characteristics of health and safety committees. A survey of 380 health and safety committee members from 176 manufacturing workplaces was supplemented with administrative data and compared with reported workers' compensation rates. Survey respondents also reported perceptions of overall safety, committee, effectiveness, committee activities, and "best practices." Extensive descriptive data is presented, including a mean of 8.7 members per committee spending 1,167 hr per year on committee business for an estimate of $40,500 worth of time per committee. Higher speed to correct action items, a focus on ergonomics, and planning for safety training was associated with lower injury rates. The discrepancy between managers and hourly committee members in estimating overall safety was strongly positively associated with injury rates. Communications and worker involvement may be important to address discrepancy issues. Prospective studies are needed to distinguish directionality of associations. Copyright © 2012 Wiley Periodicals, Inc.

  8. 77 FR 48948 - Notice of the Advisory Committee on Biotechnology and 21st Century Agriculture Meeting; Correction

    Science.gov (United States)

    2012-08-15

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Research Service Notice of the Advisory Committee on Biotechnology and... meeting of the Advisory Committee on Biotechnology and 21st Century Agriculture (AC21). The notice...

  9. TOFD代替RT应用于ASME Ⅷ-1建造设备的规范要求%Code Requirements for TOFD instead of RT Apply to ASME Ⅲ-1

    Institute of Scientific and Technical Information of China (English)

    张亚统

    2016-01-01

    根据市场发展、检测经济性和检测质量的需要,TOFD(Time of Flight Diffraction)检测方法逐步被应用于ASME规范产品的制造,但以往成功的案例基本是以ASME规范案例2235为基础,考虑到ASME规范案例随时有可能被规范取消,如何才能使用符合ASME规范要求的TOFD代替RT并应用于ASME Ⅷ-1规范的产品就变成了很多ASME持证厂家思考的问题.本文通过对ASME规范的综合分析和研究,提出了解决办法.

  10. Measurement of stoichiometric parameter and kinetic parameters in ASM1%ASM1中化学计量系数与动力学参数的测定

    Institute of Scientific and Technical Information of China (English)

    于静洁; 马超; 李莉; 顾国维; 张志峰

    2006-01-01

    为了应用活性污泥1号模型模拟印染废水为主的污水集中处理厂,针对该厂实际废水,选取关键的化学计量系数YH和动力学参数bH及H进行测定.详细叙述了YH、bH和H的测定原理及具体操作过程.YH、bH和H的实测结果分别为0.65、0.50、3.23,这些值不同于ASM1中20 ℃下城市污水的推荐值0.67、0.62、6.0.

  11. The use of Borg's modified scale in asthma crises Uso de la escala modificada de Borg en la crisis asmática Uso da escala modificada de Borg na crise asmática

    Directory of Open Access Journals (Sweden)

    Tatiana de Medeiros Colletti Cavalcante

    2008-01-01

    Full Text Available OBJECTIVE: Verify the correlation of the improvement of the degree of dyspnea by BME with improved pulmonary performance verified by Expiratory Flow Peak (EFP and Peripheral Oxygen Saturation (PO2S. METHODS: Analytical, cross-sectional study with 124 patients during an asthma crisis, who received care at a Pneumology emergency service. Heart rate, respiratory frequency EFP, PO2S were evaluated before and after treatment of asthma crisis, and they were questioned about their perception of dyspnea by BME. RESULTS: In the pre-treatment stage, high scale values were related to low EFP values, inverting this relation after treatment. There was also a slight correlation between EFP, PO2S and the perception of dyspnea measured by the patient through BME. CONCLUSION: The scale does not replace other clinical parameters, and can be used as an additional tool, provided that the patient is correctly informed about the scale values.OBJETIVO: Verificar la correlación de la mejoría del grado de disnea por medio de la EMB con la mejora de la función pulmonar verificada por el Pico de Flujo Expiratorio (PFE y Saturación Periférica de Oxígeno (spO2. MÉTODOS: Estudio analítico y transversal realizado con 124 pacientes en crisis asmática atendidos en un Servicio de emergencia de neumología. Fueron evaluados antes y después del tratamiento de la crisis asmática: frecuencia cardiaca, frecuencia respiratoria, PFE, SpO2 e interrogados sobre su percepción de la disnea por medio de la EMB. RESULTADOS: En la fase de pre-tratamiento, los valores altos de la escala estaban relacionados a los valores bajos de PFE, invirtiéndose esta relación en el post-tratamiento. Hubo también una débil correlación entre el PFE, SpO2, y la percepción de la disnea mensurada por el paciente a través de la EMB. Conclusión: La escala no sustituye otros parámetros clínicos, pudiendo ser utilizada como una herramienta adicional, siempre y cuando el paciente sea

  12. National Advisory Committee for Aeronautics

    Science.gov (United States)

    1938-01-01

    NASA was created from the National Advisory Committee on Aeronautics in 1958. This is a photo of the members of the advisory board of NACA in 1938. NACA was the governmental organization charged with the supervision and conduct of scientific laboratory research in aeronautics. Its laboratories located at Langley Field, Virginia, provide new knowledge underlying the continuous improvement in the performance, efficiency, and safety of American aircraft. At this meeting Dr. Joesph S. Ames, President Emeritus of John Hopkins University, was re-elected Chairman, and Dr. Vannevar Bush, President- elect of the Carnegie Institution of Washington, was elected Vice Chairman. Dr. Ames' re-election as chairman was a recognition of his outstanding contributions to the science of aeronautics. He has been the leading scientific member of the Committee for over twenty-three years and chairman for eleven years. Under his visionary leadership the great laboratories of the N.A.C.A. at Langley Field have been developed. Left to Right: Hon. C. M. Hester, Administrator, Civil Aeronautics Authority Captain S. M. Kraus, U.S.N. Brig. General A. W. Robins, Chief, Materiel Division, Army Air Corps. Dr. L.J. Biggs, Director, National Bureau of Standards Dr. E.P. Warner Dr. Orville Wright Dr. Joesph S. Ames, Chairman Dr. C.J. Abbot, Secretary, Smithsonian Institution J.F. Victory, Secretary Rear Adm. A.B. Cook, U.S.N., Chief, Bureau Aeronautics Authority Dr. Vannevar Bush Dr. J.C. Hunsaker Dr. G.W. Lewis, Director of Aeronautical Research. Absent: Col. Charles A. Lindbergh and Maj. Gen. H. 'Hap' Arnold, Chief, Army Air Corps. One Vacany: U.S. Weather Bureau.

  13. Transforming medical imaging: the first SCAR TRIP conference a position paper from the SCAR TRIP subcommittee of the SCAR research and development committee.

    Science.gov (United States)

    Andriole, Katherine P; Morin, Richard L

    2006-03-01

    The First Society for Computer Applications in Radiology (SCAR) Transforming the Radiological Interpretation Process (TRIP) Conference and Workshop, "Transforming Medical Imaging" was held on January 31-February 1, 2005 in Bethesda, MD. Representatives from all areas of medical and scientific imaging-academia, research, industry, and government agencies-joined together to discuss the future of medical imaging and potential new ways to manage the explosion in numbers, size, and complexity of images generated by today's continually advancing imaging technologies. The two-day conference included plenary, scientific poster, and breakout sessions covering six major research areas related to TRIP. These topic areas included human perception, image processing and computer-aided detection, data visualization, image set navigation and usability, databases and systems integration, and methodology evaluation and performance validation. The plenary presentations provided a general status review of each broad research field to use as a starting point for discussion in the breakout sessions, with emphasis on specific topics requiring further study. The goals for the breakout sessions were to define specific research questions in each topic area, to list the impediments to carrying out research in these fields, to suggest possible solutions and near- and distant-future directions for each general topic, and to report back to the general session. The scientific poster session provided another mechanism for presenting and discussing TRIP-related research. This report summarizes each plenary and breakout session, and describes the group recommendations as to the issues facing the field, major impediments to progress, and the outlook for radiology in the short and long term. The conference helped refine the definition of the SCAR TRIP Initiative and the problems facing radiology with respect to the dramatic growth in medical imaging data, and it underscored a present and future need

  14. Comportamiento de variables clínico-epidemiológicas en pacientes asmáticos. Consultorio Médico de Familia 14, Puerto Padre

    Directory of Open Access Journals (Sweden)

    José Ramón Martínez Pérez

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal en 40 pacientes asmáticos de todas las edades, pertenecientes al Consultorio 14 del área de salud de Puerto Padre, provincia de Las Tunas, durante los meses de enero a junio de 2008; con el objetivo de determinar el comportamiento de variables clínico-epidemiológicas en dichos pacientes. Para cumplimentar los objetivos se diseñó una encuesta que recogió las variables de interés. El análisis se hizo a través del sistema Statistix, permitiendo  obtener  la distribución de frecuencia y los porcientos. El test de Chi-Cuadrado se empleó en la comparación de variables cualitativas. Los resultados fueron descritos, interpretados y comparados con otros estudios. Se concluye que los pacientes grado I según Kraeppelin son los mas representados en nuestra población de pacientes asmáticos;  los broncodilatadores son los medicamentos mas utilizados por la población asmática estudiada; el incumplimiento del tratamiento medicamentoso no se relacionó con la severidad de la enfermedad en la población estudiada;  las malas condiciones de la vivienda y  el tabaquismo influyeron de forma negativa en la evolución del paciente asmático.

  15. Structural diversity in gallium(III) complexes of the tripodal triarsine MeC(CH2AsMe2)3.

    Science.gov (United States)

    Cheng, Fei; Hector, Andrew L; Levason, William; Reid, Gillian; Webster, Michael; Zhang, Wenjian

    2007-06-07

    The preparation and crystal structures of the first examples of gallium halide complexes with the tripodal arsine, MeC(CH(2)AsMe(2))3, reveal three distinctly different coordination modes for the ligand; the neutral [{micro(3)-MeC(CH(2)AsMe(2))3-kappaAs:kappaAs':kappaAs''}(GaI(3))3] with the triarsine coordinating to three GaI(3) units, [{Me(2)AsCH(2)C(Me)(CH(2)AsMe(2))2-kappa(2)AsAs'}GaCl(2)][GaCl(4)] involving bidentate chelation to a GaCl2+ cationic unit with the third As donor atom uncoordinated, and [{MeC(CH(2)AsMe(2))3-kappaAs:kappa(2)As'As''}(GaCl3)(GaCl2)][GaCl4] in which the triarsine forms a bidentate chelate to the GaCl2+ unit and the third As donor atom binds to a further GaCl3 unit.

  16. Comparisons of ANS, ASME, AWS, and NFPA standards cited in the NRC standard review plan, NUREG-0800, and related documents

    Energy Technology Data Exchange (ETDEWEB)

    Ankrum, A.R.; Bohlander, K.L.; Gilbert, E.R.; Spiesman, J.B. [Pacific Northwest Lab., Richland, WA (United States)

    1995-11-01

    This report provides the results of comparisons of the cited and latest versions of ANS, ASME, AWS and NFPA standards cited in the NRC Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants (NUREG 0800) and related documents. The comparisons were performed by Battelle Pacific Northwest Laboratories in support of the NRC`s Standard Review Plan Update and Development Program. Significant changes to the standards, from the cited version to the latest version, are described and discussed in a tabular format for each standard. Recommendations for updating each citation in the Standard Review Plan are presented. Technical considerations and suggested changes are included for related regulatory documents (i.e., Regulatory Guides and the Code of Federal Regulations) citing the standard. The results and recommendations presented in this document have not been subjected to NRC staff review.

  17. Aeração nasal em crianças asmáticas Nasal ventilation in asthmatics children

    Directory of Open Access Journals (Sweden)

    Daniele Andrade da Cunha

    2011-10-01

    Full Text Available OBJETIVO: identificar a presença de sinais de alterações na expiração de crianças asmáticas. MÉTODO: este estudo foi realizado com 30 crianças com idades entre 6 e 10 anos de ambos os sexos com diagnóstico clínico de asma confirmado pelo prontuário médico e 30 crianças não asmáticas também de ambos os sexos na mesma faixa etária. Foi avaliada a aeração nasal com o espelho milimetrado de Altmann, sendo mensurado o escape de ar nasal objetivando a verificação da saída uni ou bilateral do ar e a relação de simetria entre a narina direita e a esquerda. As imagens foram importadas para o computador por meio do scanner HP da série Scanjet 2400. A análise foi realizada no software Scion Image for Windows (Alpha 4.0.3.2. Para análise das variáveis quantitativas entre grupos foi aplicado o teste t-student e para a análise intragrupos foi aplicado o teste t-Student pareado.Todas as conclusões foram tomadas ao nível de significância de 5%, sendo usados o Excel 2000 e o SPSS v8.0, para as análises. RESULTADOS: não foram encontradas diferenças estatisticamente significantes entre as crianças asmáticas e não-ásmáticas, acerca das mensurações quanto à área total e quanto às áreas das narinas direita e esquerda. CONCLUSÃO: não foi identificada a presença de sinais de alterações na expiração de crianças asmáticas, desta forma, faz-se necessário um estudo mais específico das funções nasal e pulmonar.PURPOSE: to identify the symptoms of changes in the exhalation of asthmatic children. METHOD: this study was conducted with 30 children from 6 to 10 year-old, of both genders and with asthma clinical diagnosis confirmed by medical records and 30 non-asthmatic children from 6 to 10 year-old, of both genders, and with same age. We evaluated the nasal ventilation with Altmann millimeter nasal mirror measuring the nasal air escape in order to check their unilateral or bilateral air output and the relation of

  18. Modeling Nitrous Oxide Production during Biological Nitrogen Removal via Nitrification and Denitrification: Extensions to the General ASM Models

    DEFF Research Database (Denmark)

    Ni, Bing-Jie; Ruscalleda, Maël; Pellicer i Nàcher, Carles

    2011-01-01

    Nitrous oxide (N2O) can be formed during biological nitrogen (N) removal processes. In this work, a mathematical model is developed that describes N2O production and consumption during activated sludge nitrification and denitrification. The well-known ASM process models are extended to capture N2O...... dynamics during both nitrification and denitrification in biological N removal. Six additional processes and three additional reactants, all involved in known biochemical reactions, have been added. The validity and applicability of the model is demonstrated by comparing simulations with experimental data...... on N2O production from four different mixed culture nitrification and denitrification reactor study reports. Modeling results confirm that hydroxylamine oxidation by ammonium oxidizers (AOB) occurs 10 times slower when NO2– participates as final electron acceptor compared to the oxic pathway. Among...

  19. RXTE/ASM and Swift / BAT observations of spectral transitions in bright X-ray binaries in 2005-2010

    Institute of Scientific and Technical Information of China (English)

    Jing Tang; Wen-Fei Yu; Zhen Yan

    2011-01-01

    We have studied X-ray spectral state transitions that can be seen in the longterm monitoring light curves of bright X-ray binaries from the All-Sky Monitor (ASM) onboard the Rossi X-ray Timing Explorer (RXTE) and the Burst Alert Telescope (BAT) onboard Swift during a period of five years from 2005 to 2010. We have applied a program to automatically identify the hard-to-soft (H-S) spectral state transitions in the bright X-ray binaries monitored by the ASM and the BAT. In total, we identified 128 hard-to-soft transitions, of which 59 occurred after 2008. We also determined the transition fluxes and the peak fluxes of the following soft states, updated the measurements of the luminosity corresponding to the H-S transition and the peak luminosity of the following soft state in about 30 bright persistent and transient black hole and neutron star binaries following Yu &Yan, and found the luminosity correlation and the luminosity range of spectral transitions in data between 2008-2010 are about the same as those derived from data before 2008. This further strengthens the idea that the luminosity at which the H-S spectral transition occurs in the Galactic X-ray binaries is determined by non-stationary accretion parameters such as the rate-of-change of the mass accretion rate rather than the mass accretion rate itself. The correlation is also found to hold in data of individual sources 4U 1608-52 and 4U 1636-53.

  20. Biotechnology: The U.S. Department of Agriculture's Biotechnology Research Efforts. Briefing Report. To the Chairman, Committee on Science and Technology, House of Representatives.

    Science.gov (United States)

    General Accounting Office, Washington, DC.

    Information pertaining to biotechnology research that was funded in whole or in part by the U.S. Department of Agriculture (USDA) is presented in this report. Findings obtained from state agricultural experimental stations and colleges of veterinary medicine are discussed in 11 appendices. These include: (1) information on USDA's biotechnology…

  1. The Quality of Education and Economic Development. A World Bank Symposium. Papers prepared for the Conference of the World Bank Research Committee (Harpers Ferry, West Virginia, May 1983).

    Science.gov (United States)

    Heyneman, Stephen P., Ed.; White, Daphne Siev, Ed.

    Recent research findings on the economic implications of investments in the quality of education are examined in this report. "The Quality of Education and Economic Growth: A Review of Literature" (Lewis C. Solmon) reviews evidence on ways to develop educational policy that would stimulate economic growth in developing countries. "School Quality…

  2. Panel Discussion : Report of the APS Ad-Hoc Committee on LGBT Issues

    Science.gov (United States)

    Atherton, Tim; Barthelemy, Ramon; Garmon, Savannah; Reeves, Kyle; APS Ad-Hoc Committee on LGBT Issues Team

    Following the presentation of the findings and recommendations of the APS Ad-Hoc Committee on LGBT Issues (C-LGBT) by Committee Chair Michael Falk, a panel discussion will be held featuring several members of the committee. The discussion will focus on how APS can best ensure the recommendations of the committee are carried out in a timely fashion and other ideas on future APS efforts toward LGBT inclusion in physics. Discussion topics will also include the research and other input that shaped the committee's findings and recommendations.

  3. Study of Cooperative Attack Control Law for ASM with Leader-follower Structure%反舰导弹主从式协同攻击样式

    Institute of Scientific and Technical Information of China (English)

    叶利民; 孙锋吾; 陶山

    2012-01-01

    In order to' research the dynamic behavior of cooperative attack style for ASM, a nonlinear mathematical model of leader-follower attack style is built based on the relative moving equation between the leader missile and the follower missile. According to the error dynamic of relative distance and yaw angle, the control law is designed by the theory of feedback linearization, and the stabilization of the control law and the inner dynamic system are proved. The simulated results with an example shows that all follower missiles can be close to their desired value quickly and move together with stable structure by means of the proposed control law.%针对群弹系统执行攻击任务时,从弹按照主从式协同攻击样式跟随领弹实施攻击,利用领弹与从弹的位置信息解算出相对距离和角度,依据相对距离和角度误差的动力学特性,建立了主从式协同攻击样式的非线性数学模型,采用输出线性化理论设计了主从式协同攻击样式的控制律,证明了该控制律及其内动态系统的稳定性.仿真表明,在领弹机动条件下,实现了对从弹的速度和弹道偏航角的控制,从弹能保持与领弹的相对距离和弹道偏航角均快速收敛并稳定到期望值.

  4. NGO Work Committee Visits Beijing

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    ON June 27, 19 members of the Work Committee of the UN FWCW’s 1995 NGO Forum on Women arrived in Beijing. During their five-day visit in the capital they talked with representatives from the host country about preparations for the forum, the meeting place, facilities and other relevant matters. Huang Qizao, Vice-Chairperson of the FWCW’s China Organizing Committee, Committee Director of the NGO Forum and

  5. TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice.

    Science.gov (United States)

    Li, Xiang; Han, Wei-Qing; Boini, Krishna M; Xia, Min; Zhang, Yang; Li, Pin-Lan

    2013-01-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor, death receptor 4 (DR4), have been implicated in the development of endothelial dysfunction and atherosclerosis. However, the signaling mechanism mediating DR4 activation leading to endothelial injury remains unclear. We recently demonstrated that ceramide production via hydrolysis of membrane sphingomyelin by acid sphingomyelinase (ASM) results in membrane raft (MR) clustering and the formation of important redox signaling platforms, which play a crucial role in amplifying redox signaling in endothelial cells leading to endothelial dysfunction. The present study aims to investigate whether TRAIL triggers MR clustering via lysosome fusion and ASM activation, thereby conducting transmembrane redox signaling and changing endothelial function. Using confocal microscopy, we found that TRAIL induced MR clustering and co-localized with DR4 in coronary arterial endothelial cells (CAECs) isolated from wild-type (Smpd1 (+/+)) mice. Furthermore, TRAIL triggered ASM translocation, ceramide production, and NADPH oxidase aggregation in MR clusters in Smpd1 ( +/+ ) CAECs, whereas these observations were not found in Smpd1 (-/-) CAECs. Moreover, ASM deficiency reduced TRAIL-induced O(2) (-[Symbol: see text]) production in CAECs and abolished TRAIL-induced impairment on endothelium-dependent vasodilation in small resistance arteries. By measuring fluorescence resonance energy transfer, we found that Lamp-1 (lysosome membrane marker protein) and ganglioside G(M1) (MR marker) were trafficking together in Smpd1 (+/+) CAECs, which was absent in Smpd1 (-/-) CAECs. Consistently, fluorescence imaging of living cells with specific lysosome probes demonstrated that TRAIL-induced lysosome fusion with membrane was also absent in Smpd1 (-/-) CAECs. Taken together, these results suggest that ASM is essential for TRAIL-induced lysosomal trafficking, membrane fusion and formation of MR redox signaling platforms

  6. Business ethics in ethics committees?

    Science.gov (United States)

    Boyle, P

    1990-01-01

    The "Ethics committees" column in this issue of the Hastings Center Report features an introduction by Cynthia B. Cohen and four brief commentaries on the roles hospital ethics committees may play in the making of institutional and public health care policy in the 1990s. The pros and cons of a broader, more public role for ethics committees in reconciling the business and patient care aspects of health care delivery are debated by Cohen in "Ethics committees as corporate and public policy advocates," and by Philip Boyle in this article. Boyle is an associate for ethical studies at The Hastings Center.

  7. 76 FR 66880 - Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee Meetings...

    Science.gov (United States)

    2011-10-28

    ... CFR Chapter VI Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee... set a schedule for committee meetings. DATES: We must receive your nominations for negotiators to...: Notice of establishment of negotiated rulemaking committee. SUMMARY: We announce our intention...

  8. 78 FR 71631 - Committee Name: Homeland Security Information Network Advisory Committee (HSINAC)

    Science.gov (United States)

    2013-11-29

    ... SECURITY Committee Name: Homeland Security Information Network Advisory Committee (HSINAC) AGENCY... Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The Homeland Security Information Network... Homeland Security Information Network Advisory Committee (HSINAC) is an advisory body to the...

  9. [Ethics in committees].

    Science.gov (United States)

    Hottois, Gilbert

    2007-01-01

    The management of techno-scientific and multicultural societies, open and evolving, can neither be conceived nor carried out on the basis of fundamentalist, essentialist rules that are characteristic of closed, immobile societies. Within a global civilisation, fundamentalisms are only acceptable as individual or community beliefs. Against the background of our civilisation on the chaotic road to globalisation described here, what are the methodological rules for bioethics committees? A first rule concerns the composition of the committees: it must be multidisciplinary and pluralist. The second rule concerns the distinction of types, which is less evident at a time which cultivates postmodernism. The "types" which absolutely must be distinguished are: science, ethics, morals, law, politics. The third rule concerns the concluding procedures. A majority vote procedure after information and limited discussion makes it possible to conclude easily and rapidly. But it generally seems not to be very ethical, especially if it does not allow minorities to have their divergent opinions appear among the conclusions in an explicit argued manner. The "lazy dissensus" must, however also be avoided: it consists in not really engaging the interdisciplinary, pluralist discussion, simply exposing and explaining each position, on the pretext that pluralism is respecting diversity, the freedom to believe, to think and to express oneself either each for himself or in the name of one's community or tradition. This sort of "postmodern" methodology, individualistic and communitarian to an extreme, is precariously balanced in relation to the committee's ethical vocation. It is therefore very important that an ethics committee really engages in discussion and expresses, let's say, a preference for consensus. This preference is the expression of its "ethical" nature: in this word (as in the word "moral", in fact), there is a reference to what is common, to what unites and makes social life

  10. 50 CFR 453.05 - Committee meetings.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Committee meetings. 453.05 Section 453.05... ENDANGERED SPECIES COMMITTEE § 453.05 Committee meetings. (a) The committee shall meet at the call of the... among themselves how it will be cast. (e) All meetings and records of the Committee shall be open to...

  11. Pulsed Power Peer Review Committee Report

    Energy Technology Data Exchange (ETDEWEB)

    BLOOMQUIST,DOUGLAS D.

    2000-12-01

    In 1993, the Government Performance and Results Act (GPRA, PL 103-62) was enacted. GPRA, which applies to all federal programs, has three components: strategic plans, annual performance plans, and metrics to show how well annual plans are being followed. As part of meeting the GRPA requirement in FY2000, a 14-member external peer review panel (the Garwin Committee) was convened on May 17-19, 2000 to review Sandia National Laboratories' Pulsed Power Programs as a component of the Performance Appraisal Process negotiated with the Department of Energy (DOE). The scope of the review included activities in inertial confinement fission (ICF), weapon physics, development of radiation sources for weapons effects simulation, x-ray radiography, basic research in high energy density physics (HEDP), and pulsed power technology research and development. In his charge to the committee, Jeffrey Quintenz, Director of Pulsed Power Sciences (1600) asked that the review be based on four criteria (1) quality of science, technology, and engineering, (2) programmatic performance, management, and planning, (3) relevance to national needs and agency missions, and (4) performance in the operation and construction of major research facilities. In addition, specific programmatic questions were posed by the director and by the DOE-Defense Programs (DP). The accompanying report, produced as a SAND document, is the report of the committee's findings.

  12. STANDING CONCERTATION COMMITTEE

    CERN Multimedia

    2003-01-01

    ORDINARY MEETING ON 29 SEPTEMBER 2003 Original: English This meeting was devoted to the main topics summarised below. 1 Follow-up from the meetings of TREF and the Finance Committee in September 2003 The last meeting of TREF had been devoted to presentations and clarifications on the 5-Yearly Review process. The content and planning of the 2005 Review are matters for the next Management, which will be presented to TREF next year. Underlining that due account has to be taken of the limited resources available to conduct such an exercise, the Staff Association stated that it looks forward to the concertation process at the SCC in preparing the next 5-Yearly Review to define an optimum set of topics in order to ensure that CERN can attract, retain and motivate the personnel that it needs to remain a centre of excellence. The Chairman of the SCC recalled that an information document on the Cost-Variation Index for 2004 had been transmitted to the Finance Committee last September and that complete information o...

  13. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee.

    Science.gov (United States)

    Rossini, P M; Burke, D; Chen, R; Cohen, L G; Daskalakis, Z; Di Iorio, R; Di Lazzaro, V; Ferreri, F; Fitzgerald, P B; George, M S; Hallett, M; Lefaucheur, J P; Langguth, B; Matsumoto, H; Miniussi, C; Nitsche, M A; Pascual-Leone, A; Paulus, W; Rossi, S; Rothwell, J C; Siebner, H R; Ugawa, Y; Walsh, V; Ziemann, U

    2015-06-01

    These guidelines provide an up-date of previous IFCN report on "Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application" (Rossini et al., 1994). A new Committee, composed of international experts, some of whom were in the panel of the 1994 "Report", was selected to produce a current state-of-the-art review of non-invasive stimulation both for clinical application and research in neuroscience. Since 1994, the international scientific community has seen a rapid increase in non-invasive brain stimulation in studying cognition, brain-behavior relationship and pathophysiology of various neurologic and psychiatric disorders. New paradigms of stimulation and new techniques have been developed. Furthermore, a large number of studies and clinical trials have demonstrated potential therapeutic applications of non-invasive brain stimulation, especially for TMS. Recent guidelines can be found in the literature covering specific aspects of non-invasive brain stimulation, such as safety (Rossi et al., 2009), methodology (Groppa et al., 2012) and therapeutic applications (Lefaucheur et al., 2014). This up-dated review covers theoretical, physiological and practical aspects of non-invasive stimulation of brain, spinal cord, nerve roots and peripheral nerves in the light of more updated knowledge, and include some recent extensions and developments.

  14. ¿Por qué auditar a los comités de ética en investigación? Why to audit to research ethics committees?

    Directory of Open Access Journals (Sweden)

    Estela Quiroz

    2010-09-01

    Full Text Available Los comités de ética en investigación biomédica tienen como responsabilidad asegurar la protección de los participantes humanos en las investigaciones. Para mejorar la calidad de su trabajo deben someterse a procedimientos de auditoría, encargadas por los patrocinadores, y de inspecciones por parte de la autoridad regulatoria. A través de dichos procedimientos se garantizaría que mejoren sus funciones, y así puedan perfeccionar su labor y cumplir de manera óptima con el objetivo para el que fueron creados.Ethics committees in biomedical research have the responsibility to ensure the protection of human participants in the studies. In order to improve the quality of their work they must undergo audit procedures commissioned by the sponsors and inspections done by the regulatory authorities. Through these procedures, improvement of their functions should be guaranteed, so they can optimize their tasks and accomplish in the best way the purpose for which they were created.

  15. Proposed replacement nuclear research reactor at Lucas Heights Science and Technology Centre, NSW. Statement of evidence to the Parliamentary Standing Committee on Public Works

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    This submission demonstrates the manner in which the replacement research reactor project is to be undertaken in accordance with all relevant Commonwealth requirements and standards. Successive submissions to Government have shown that the construction and operation of the replacement reactor will result in a range of significant benefits to Australia in the areas of health care, the national interest, scientific achievement and in industrial applications. ANSTO is confident that the construction and operation of the replacement research reactor will: meet the identified needs for an ongoing neutron source for Australia into the next century in a cost-effective manner; be effectively managed to ensure that the project is delivered to the agreed schedule and budget; involve an effective community consultation process with ongoing community consultation a feature of ANSTO`s approach; will have negligible environmental and public health implications taking account of the environmental management measures and commitments made by ANSTO in the Environmental Impact Statement and the stringent licensing arrangement by ARPANSA 24 refs., 8 tabs., 5 figs.

  16. Data monitoring committees for pragmatic clinical trials.

    Science.gov (United States)

    Ellenberg, Susan S; Culbertson, Richard; Gillen, Daniel L; Goodman, Steven; Schrandt, Suzanne; Zirkle, Maryan

    2015-10-01

    In any clinical trial, it is essential to monitor the accumulating data to be sure that the trial continues to be safe for participants and that the trial is being conducted properly. Data monitoring committees, independent expert panels who undertake regular reviews of the data as the trial progresses, serve an important role in safeguarding the interests of research participants and ensuring trial integrity in many trials. Many pragmatic clinical trials, which aim to inform healthcare decisions by comparing alternate interventions in heterogeneous healthcare delivery settings, will warrant review by an independent data monitoring committee due to their potential impact on clinical practice. However, the very features that make a trial "pragmatic" may pose challenges in terms of which aspects of a trial to monitor and when it is appropriate for a data monitoring committee to intervene. Using the Pragmatic-Explanatory Continuum Indicator Summary tool that draws distinctions between pragmatic and explanatory clinical trials, we review characteristics of pragmatic clinical trials that may have implications for data monitoring committees and interim monitoring plans. These include broad eligibility criteria, a focus on subjective patient-centered outcomes, and in some cases a lack of standardized follow-up procedures across study sites. Additionally, protocol adherence is often purposefully not addressed in pragmatic trials in order to accurately represent the clinical practice setting and maintain practicability of implementation; there are differing viewpoints as to whether adherence should be assessed and acted upon by data monitoring committees in these trials. Some other issues not specifically related to the Pragmatic-Explanatory Continuum Indicator Summary criteria may also merit special consideration in pragmatic trials. Thresholds for early termination of a pragmatic clinical trial might be controversial. The distinguishing features of pragmatic clinical

  17. How to evaluate the risks of work equipment and installations for health and safety? Research and activities of the German Committee for Plant Safety and consequences for regulation.

    Science.gov (United States)

    Pieper, R

    2012-01-01

    Work equipment and installations with a high risk for health and safety of employees should be paid a special attention. The German Product Safety Act, which is aimed to manufacturers or distributors in order to protect consumers, maintains a conclusive catalogue of these so-called "installations in need of monitoring" fixing the work equipment and installations for which such special inspections can be demanded. This catalogue has remained unchanged for decades and has been transformed nearly unmodified into the Plant Safety Ordinance. Currently, there is a discussion about this catalogue in Germany. A major point of concern is the definition and the significance of "especially" dangerous work equipment and installations. Two recent research projects are dealing with the problem how to define "especially".

  18. 76 FR 66891 - Committee on Rulemaking

    Science.gov (United States)

    2011-10-28

    ...'' section of the Conference's Web site, at http://www.acus.gov . Click on ``About'' -> ``The Committees'' -> ``Committee on Rulemaking.'' Comments may be submitted by email to Comments@acus.gov , with ``Committee...

  19. 75 FR 22435 - Notice of Committee Meeting

    Science.gov (United States)

    2010-04-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Notice of Committee Meeting Title: Shipping Coordinating Committee; Notice of Committee Meeting. The... of the human element --Formal safety assessment --Piracy and armed robbery against ships...

  20. 75 FR 28542 - Superior Resource Advisory Committee

    Science.gov (United States)

    2010-05-21

    ... orient the new Superior Resource Advisory Committee members on their roles and responsibilities. DATES... of the roles and responsibilities of the Superior Resource Advisory Committee members; Election of... Forest Service Superior Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice...