Coincidence scanning with positron-emitting arsenic or copper in the diagnosis of focal intracranial disease; Exploration par coincidences avec l'Arsenic ou le Cuivre Emetteurs de Positrons dans le Diagnostic des Maladies intracraniennes localisees; Raspoznavanie ochagovykh vnutricherepnykh zabolevanij putem podscheta (skanirovaniya) sovpralenij s primeneniem mysh'yaka ili medi, vydelyayushchikh pozitrony; Exploracion por coincidencia con arsenico o cobre emisores de positrones en el diagnostico de enfermedades intracraneanas localizadas

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Sweet, William H; Mealey, John Jr; Brownell, Gordon L; Aronow, Saul [Departments of Surgery and Medicine, Harvard Medical School, and Neurosurgical Service and Physics Research Laboratory of Massachusetts General Hospital, Boston, MA (United States)

1959-07-01

kontsentratsiej v tkani normal'nogo mozga dostigaet 30 dlya opukholej myagkikh mozgovykh obolochek (meningiom). Ostal'nye glavnye vidy opukholej, perechislennye v poryadke umen'shayushchejs ya kontsentratsii izotopa, sleduyushchie: slukhovye nevromy, glioblastomy, zlokachestvenny e metastazy i astrotsitomy. Sil'noe pogloshchenie mysh'yaka v tkani opukholi prodolzhaetsya dostatochno dolgo, chtoby povtornoe skanirovanie cherez 24 chasa posle in{sup e}ktsii davalo polozhitel'nye rezul'taty. Koehffitsient sootnosheniya mezhdu kontsentratsiej v myshtsakhiv mozgu nastol'tko velik, chto on prepyatstvuet ustanovleniyu tochnogo diagnoza, esli porazheniya raspolozheny pod nizhnimi myshtsami viska i osobenno pod verkhnimi myshtsami zatylka. Raznitsa v zakhvate izotopa mezhdu normal'noj i bol'noj tkanyo pri nalichii krovyanykh opukholej, abstsessov i zon razrusheniya mielina takzhe dostatochno znachitel'na, chtoby mozhno bylo lokalizirovat' dannoe zabolevanie u bol'shinstva patsientov. Biopsiya tkani, soderzhashchej mednyj versenat, vyyavila nalichie analogichnykh koehffitsientov , poskol'ku ikh mozhno opredelit' pri pomoshchi men'shego chisla obraztsov. Meningiomy, veroyatno, predstavlyayut soboj isklyuchenie v tom smysle, chto pri ispol'zovanii medi upomyanutye koeffitsienty yavlyayutsya bolee nizkimi. Na osnovanii analiza radioaktivnost i kak mochi, tak i vsekh vidov poluchaemykh posle posmertnogo vskrytiya tkanej my ustanovili, chto pri ispol'zovanii izotopa As{sup 74} obshchee obluchenie tela ravnyaetsya priblizitel'n o 3,2 rad posle vvedeniya obychnoj dlya skanirovaniya dozy v 2,3 millikyuri na 70 kg. vesa. Pochki pogloshchayut okolo 12,7, a pechen' 9,7 rad. Sootvetstvuyushchie tsifry dlya izotopa Cu{sup 64} sleduyushchie: 325 rad dlya vsego tela, prichem pechen' pogloshchaet 3,2 rad, tak kak ehtot organ zakhvatyvaet priblizitel'n o polovinu vvedennogo v organizm versenata. Avtomaticheskoe skanirovanie daet v dvukh odnovremenno poluchaemykh bokovykh zapisyakh podschet sovpadenij ili