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Sample records for asce environmental engineering

  1. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan : ASC software quality engineering practices Version 3.0.

    Energy Technology Data Exchange (ETDEWEB)

    Turgeon, Jennifer L.; Minana, Molly A.; Hackney, Patricia; Pilch, Martin M.

    2009-01-01

    The purpose of the Sandia National Laboratories (SNL) Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. Quality is defined in the US Department of Energy/National Nuclear Security Agency (DOE/NNSA) Quality Criteria, Revision 10 (QC-1) as 'conformance to customer requirements and expectations'. This quality plan defines the SNL ASC Program software quality engineering (SQE) practices and provides a mapping of these practices to the SNL Corporate Process Requirement (CPR) 001.3.6; 'Corporate Software Engineering Excellence'. This plan also identifies ASC management's and the software project teams responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals. This SNL ASC Software Quality Plan establishes the signatories commitments to improving software products by applying cost-effective SQE practices. This plan enumerates the SQE practices that comprise the development of SNL ASC's software products and explains the project teams opportunities for tailoring and implementing the practices.

  2. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan. Part 1 : ASC software quality engineering practices version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Minana, Molly A.; Sturtevant, Judith E.; Heaphy, Robert; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Forsythe, Christi A.; Schofield, Joseph Richard, Jr.; Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2005-01-01

    The purpose of the Sandia National Laboratories (SNL) Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. Quality is defined in DOE/AL Quality Criteria (QC-1) as conformance to customer requirements and expectations. This quality plan defines the ASC program software quality practices and provides mappings of these practices to the SNL Corporate Process Requirements (CPR 1.3.2 and CPR 1.3.6) and the Department of Energy (DOE) document, ASCI Software Quality Engineering: Goals, Principles, and Guidelines (GP&G). This quality plan identifies ASC management and software project teams' responsibilities for cost-effective software engineering quality practices. The SNL ASC Software Quality Plan establishes the signatories commitment to improving software products by applying cost-effective software engineering quality practices. This document explains the project teams opportunities for tailoring and implementing the practices; enumerates the practices that compose the development of SNL ASC's software products; and includes a sample assessment checklist that was developed based upon the practices in this document.

  3. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan. Part 1: ASC software quality engineering practices, Version 2.0.

    Energy Technology Data Exchange (ETDEWEB)

    Sturtevant, Judith E.; Heaphy, Robert; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Minana, Molly A.; Hackney, Patricia; Forsythe, Christi A.; Schofield, Joseph Richard, Jr. (,; .); Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2006-09-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR 1.3.2 and 1.3.6 and to a Department of Energy document, ASCI Software Quality Engineering: Goals, Principles, and Guidelines. This document also identifies ASC management and software project teams responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  4. Fundamentals of civil engineering an introduction to the ASCE body of knowledge

    CERN Document Server

    McCuen, Richard H; Wong, Melanie K

    2011-01-01

    While the ASCE Body of Knowledge (BOK2) is the codified source for all technical and non-technical information necessary for those seeking to attain licensure in civil engineering, recent graduates have notoriously been lacking in the non-technical aspects even as they excel in the technical. Fundamentals of Civil Engineering: An Introduction to the ASCE Body of Knowledge addresses this shortfall and helps budding engineers develop the knowledge, skills, and attitudes suggested and implied by the BOK2. Written as a resource for all of the non-technical outcomes not specifically covered in the

  5. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan part 2 mappings for the ASC software quality engineering practices, version 2.0.

    Energy Technology Data Exchange (ETDEWEB)

    Heaphy, Robert; Sturtevant, Judith E.; Hodges, Ann Louise; Boucheron, Edward A.; Drake, Richard Roy; Minana, Molly A.; Hackney, Patricia; Forsythe, Christi A.; Schofield, Joseph Richard, Jr. (,; .); Pavlakos, Constantine James; Williamson, Charles Michael; Edwards, Harold Carter

    2006-09-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR001.3.2 and CPR001.3.6 and to a Department of Energy document, ''ASCI Software Quality Engineering: Goals, Principles, and Guidelines''. This document also identifies ASC management and software project teams' responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  6. Performance Measurement of Advanced Stirling Convertors (ASC-E3)

    Science.gov (United States)

    Oriti, Salvatore M.

    2013-01-01

    NASA Glenn Research Center (GRC) has been supporting development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG project is providing life, reliability, and performance testing data of the Advanced Stirling Convertor (ASC). The latest version of the ASC (ASC-E3, to represent the third cycle of engineering model test hardware) is of a design identical to the forthcoming flight convertors. For this generation of hardware, a joint Sunpower and GRC effort was initiated to improve and standardize the test support hardware. After this effort was completed, the first pair of ASC-E3 units was produced by Sunpower and then delivered to GRC in December 2012. GRC has begun operation of these units. This process included performance verification, which examined the data from various tests to validate the convertor performance to the product specification. Other tests included detailed performance mapping that encompassed the wide range of operating conditions that will exist during a mission. These convertors were then transferred to Lockheed Martin for controller checkout testing. The results of this latest convertor performance verification activity are summarized here.

  7. Advanced Stirling Convertor (ASC) Technology Maturation

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Scott; Collins, Josh; Wilson, Kyle

    2016-01-01

    The Advanced Stirling Convertor (ASC) development effort was initiated by NASA Glenn Research Center with contractor Sunpower, Inc., to develop high-efficiency thermal-to-electric power conversion technology for NASA Radioisotope Power Systems (RPSs). Early successful performance demonstrations led to the expansion of the project as well as adoption of the technology by the Department of Energy (DOE) and system integration contractor Lockheed Martin Space Systems Company as part of the Advanced Stirling Radioisotope Generator (ASRG) flight project. The ASRG integrates a pair of ASCs to convert the heat from a pair of General Purpose Heat Source (GPHS) modules into electrical power. The expanded NASA ASC effort included development of several generations of ASC prototypes or engineering units to help prepare the ASC technology and Sunpower for flight implementation. Sunpower later had two parallel contracts allowing the last of the NASA engineering units called ASC-E3 to serve as pathfinders for the ASC-F flight convertors being built for DOE. The ASC-E3 convertors utilized the ASC-F flight specifications and were built using the ASC-F design and process documentation. Shortly after the first ASC-F pair achieved initial operation, due to budget constraints, the DOE ASRG flight development contract was terminated. NASA continues to invest in the development of Stirling RPS technology including continued production of the ASC-E3 convertors, seven of which have been delivered with one additional unit in production. Starting in fiscal year 2015, Stirling Convertor Technology Maturation has been reorganized as an element of the RPS Stirling Cycle Technology Development (SCTD) Project and long-term plans for continued Stirling technology advancement are in reformulation. This paper provides a status on the ASC project, an overview of advancements made in the design and production of the ASC at Sunpower, and a summary of acceptance tests, reliability tests, and tactical

  8. Advanced Stirling Convertor (ASC) Development for NASA RPS

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Scott; Collins, Josh

    2014-01-01

    Sunpower's Advanced Stirling Convertor (ASC) initiated development under contract to the NASA Glenn Research Center (GRC) and after a series of successful demonstrations, the ASC began transitioning from a technology development project to flight development project. The ASC has very high power conversion efficiency making it attractive for future Radioisotope Power Systems (RPS) in order to make best use of the low plutonium-238 fuel inventory in the U.S. In recent years, the ASC became part of the NASA-Department of Energy Advanced Stirling Radioisotope Generator (ASRG) Integrated Project. Sunpower held two parallel contracts to produce ASC convertors, one with the Department of Energy/Lockheed Martin to produce the ASC-F flight convertors, and one with NASA GRC for the production of ASC-E3 engineering units, the initial units of which served as production pathfinders. The integrated ASC technical team successfully overcame various technical challenges that led to the completion and delivery of the first two pairs of flight-like ASC-E3 by 2013. However, in late Fall 2013, the DOE initiated termination of the Lockheed Martin ASRG flight development contract driven primarily by budget constraints. NASA continues to recognize the importance of high efficiency ASC power conversion for RPS and continues investment in the technology including the continuation of ASC-E3 production at Sunpower and the assembly of the ASRG Engineering Unit #2. This paper provides a summary of ASC technical accomplishments, overview of tests at GRC, plans for continued ASC production at Sunpower, and status of Stirling technology development.

  9. Structure of AscE and Induced Burial Regions in AscE and AscG upon Formation of the Chaperone Needle-subunit Complex of Type III Secretion System in Aeromonas Hydrophila

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Y.; Yu, H; Leung, K; Sivaraman, J; Mok, Y

    2008-01-01

    In the type III secretion system (T3SS) of Aeromonas hydrophila, the putative needle complex subunit AscF requires both putative chaperones AscE and AscG for formation of a ternary complex to avoid premature assembly. Here we report the crystal structure of AscE at 2.7 A resolution and the mapping of buried regions of AscE, AscG, and AscF in the AscEG and AscEFG complexes using limited protease digestion. The dimeric AscE is comprised of two helix-turn-helix monomers packed in an antiparallel fashion. The N-terminal 13 residues of AscE are buried only upon binding with AscG, but this region is found to be nonessential for the interaction. AscE functions as a monomer and can be coexpressed with AscG or with both AscG and AscF to form soluble complexes. The AscE binding region of AscG in the AscEG complex is identified to be within the N-terminal 61 residues of AscG. The exposed C-terminal substrate-binding region of AscG in the AscEG complex is induced to be buried only upon binding to AscF. However, the N-terminal 52 residues of AscF remain exposed even in the ternary AscEFG complex. On the other hand, the 35-residue C-terminal region of AscF in the complex is resistant to protease digestion in the AscEFG complex. Site-directed mutagenesis showed that two C-terminal hydrophobic residues, Ile83 and Leu84, of AscF are essential for chaperone binding.

  10. Repair of Achilles tendon defect with autologous ASCs engineered tendon in a rabbit model.

    Science.gov (United States)

    Deng, Dan; Wang, Wenbo; Wang, Bin; Zhang, Peihua; Zhou, Guangdong; Zhang, Wen Jie; Cao, Yilin; Liu, Wei

    2014-10-01

    Adipose derived stem cells (ASCs) are an important cell source for tissue regeneration and have been demonstrated the potential of tenogenic differentiation in vitro. This study explored the feasibility of using ASCs for engineered tendon repair in vivo in a rabbit Achilles tendon model. Total 30 rabbits were involved in this study. A composite tendon scaffold composed of an inner part of polyglycolic acid (PGA) unwoven fibers and an outer part of a net knitted with PGA/PLA (polylactic acid) fibers was used to provide mechanical strength. Autologous ASCs were harvested from nuchal subcutaneous adipose tissues and in vitro expanded. The expanded ASCs were harvested and resuspended in culture medium and evenly seeded onto the scaffold in the experimental group, whereas cell-free scaffolds served as the control group. The constructs of both groups were cultured inside a bioreactor under dynamic stretch for 5 weeks. In each of 30 rabbits, a 2 cm defect was created on right side of Achilles tendon followed by the transplantation of a 3 cm cell-seeded scaffold in the experimental group of 15 rabbits, or by the transplantation of a 3 cm cell-free scaffold in the control group of 15 rabbits. Animals were sacrificed at 12, 21 and 45 weeks post-surgery for gross view, histology, and mechanical analysis. The results showed that short term in vitro culture enabled ASCs to produce matrix on the PGA fibers and the constructs showed tensile strength around 50 MPa in both groups (p > 0.05). With the increase of implantation time, cell-seeded constructs gradually form neo-tendon and became more mature at 45 weeks with histological structure similar to that of native tendon and with the presence of bipolar pattern and D-periodic structure of formed collagen fibrils. Additionally, both collagen fibril diameters and tensile strength increased continuously with significant difference among different time points (p tendon tissue with fibril structure observable only at 45 weeks

  11. Advanced Stirling Convertor (ASC-E2) Characterization Testing

    Science.gov (United States)

    Williams, Zachary D.; Oriti, Salvatore M.

    2012-01-01

    Testing has been conducted on Advanced Stirling Convertors (ASCs)-E2 at NASA Glenn Research Center in support of the Advanced Stirling Radioisotope Generator (ASRG) project. This testing has been conducted to understand sensitivities of convertor parameters due to environmental and operational changes during operation of the ASRG in missions to space. This paper summarizes test results and explains the operation of the ASRG during space missions

  12. ASC-PROBA Interface Control Document

    DEFF Research Database (Denmark)

    Betto, Maurizio; Jørgensen, John Leif; Jørgensen, Finn E

    1999-01-01

    of Automation of the Technical University of Denmark. The document is structured as follows. First we present the ASC - heritage, system description, performance - then we address more specifically the environmental properties, like the EMC compatibility and thermal characteristics, and the design...... and reliability issues. Section 6 deals with the testing and the calibration procedures and in section 7 the mechanical and electrical interfaces are given. In section 8 and 9 we address issues like manufacturing, transportation and storage and to conclude we review the ASC specifications against the PROBA...

  13. Pathfinding the Flight Advanced Stirling Convertor Design with the ASC-E3

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Kyle; Smith, Eddie; Collins, Josh

    2012-01-01

    The Advanced Stirling Convertor (ASC) was initially developed by Sunpower, Inc. under contract to NASA Glenn Research Center (GRC) as a technology development project. The ASC technology fulfills NASA's need for high efficiency power convertors for future Radioisotope Power Systems (RPS). Early successful technology demonstrations between 2003 to 2005 eventually led to the expansion of the project including the decision in 2006 to use the ASC technology on the Advanced Stirling Radioisotope Generator (ASRG). Sunpower has delivered 22 ASC convertors of progressively mature designs to date to GRC. Currently, Sunpower with support from GRC, Lockheed Martin Space System Company (LMSSC), and the Department of Energy (DOE) is developing the flight ASC-F in parallel with the ASC-E3 pathfinders. Sunpower will deliver four pairs of ASC-E3 convertors to GRC which will be used for extended operation reliability assessment, independent validation and verification testing, system interaction tests, and to support LMSSC controller verification. The ASC-E3 and -F convertors are being built to the same design and processing documentation and the same product specification. The initial two pairs of ASC-E3 are built before the flight units and will validate design and processing changes prior to implementation on the ASC-F flight convertors. This paper provides a summary on development of the ASC technology and the status of the ASC-E3 build and how they serve the vital pathfinder role ahead of the flight build for ASRG. The ASRG is part of two of the three candidate missions being considered for selection for the Discovery 12 mission.

  14. 77 FR 25168 - Appraisal Subcommittee (ASC); ASC Rules of Operation; Amended

    Science.gov (United States)

    2012-04-27

    ... heads of the Bureau of Consumer Financial Protection and the Federal Housing Finance Agency. The ASC Rules of Operation serve as corporate bylaws outlining the ASC's purpose, functions, authority... Title XI. The ASC Rules of Operation serve as corporate bylaws outlining the ASC's purpose, functions...

  15. 75 FR 80813 - Appraisal Subcommittee (ASC); ASC Rules of Operation; Amended

    Science.gov (United States)

    2010-12-23

    ... name and must rely on the General Services Administration (GSA) for the procurement of office space by... administration, procurement, and other services, consistent with directives of the ASC. In executing this... Conduct Section 11.01. Ethics Provision. The ASC members of the ASC and its officers and employees shall...

  16. The Effects of Environmental Factors on Smooth Muscle Cells Differentiation from Adipose-Derived Stem Cells and Esophagus Tissues Engineering

    DEFF Research Database (Denmark)

    Wang, Fang

    Adipose-derived stem cells (ASCs) are increasingly being used for regenerative medicine and tissue engineering. Smooth muscle cells (SMCs) can be differentiated from ASCs. Oxygen is a key factor influencing the stem cell differentiation. Tissue engineered esophagus has been a preferred solution...... of esophagus was studied. Our results showed that both SMCs and ASCs could attach on the porcine esophageal acellular matrix (EAM) scaffold in vitro after 24 hours and survive until 7 days. Thus ASCs might be a substitute for SMCs in the construction of tissue engineered esophageal muscle layer....

  17. ASC-1

    DEFF Research Database (Denmark)

    Jakimoski, Goce; Khajuria, Samant

    2011-01-01

    uses leak extraction from diÆerent AES rounds to compute the key material that is XOR-ed with the message to compute the ciphertext. Unlike LEX, the ASC-1 operates in a CFB fashion to compute an authentication tag over the encrypted message. We argue that ASC-1 is secure by reducingits (IND-CCA , INT......The goal of the modes of operation for authenticated encryption is to achieve faster encryption and message authentication by performing both the encryption and the message authentication in a single pass as opposed to the traditional encrypt-then-mac approach, which requires two passes....... Unfortunately, the use of a block cipher as a building block limits the performance of the authenticated encryption schemes to at most one message block per block cipher evaluation. In this paper, we propose the authenticated encryption scheme ASC-1 (Authenticating Stream Cipher One). Similarly to LEX, ASC-1...

  18. Comparison of Simulated Microgravity and Hydrostatic Pressure for Chondrogenesis of hASC.

    Science.gov (United States)

    Mellor, Liliana F; Steward, Andrew J; Nordberg, Rachel C; Taylor, Michael A; Loboa, Elizabeth G

    2017-04-01

    Cartilage tissue engineering is a growing field due to the lack of regenerative capacity of native tissue. The use of bioreactors for cartilage tissue engineering is common, but the results are controversial. Some studies suggest that microgravity bioreactors are ideal for chondrogenesis, while others show that mimicking hydrostatic pressure is crucial for cartilage formation. A parallel study comparing the effects of loading and unloading on chondrogenesis has not been performed. The goal of this study was to evaluate chondrogenesis of human adipose-derived stem cells (hASC) under two different mechanical stimuli relative to static culture: microgravity and cyclic hydrostatic pressure (CHP). Pellets of hASC were cultured for 14 d under simulated microgravity using a rotating wall vessel bioreactor or under CHP (7.5 MPa, 1 Hz, 4 h · d-1) using a hydrostatic pressure vessel. We found that CHP increased mRNA expression of Aggrecan, Sox9, and Collagen II, caused a threefold increase in sulfated glycosaminoglycan production, and resulted in stronger vimentin staining intensity and organization relative to microgravity. In addition, Wnt-signaling patterns were altered in a manner that suggests that simulated microgravity decreases chondrogenic differentiation when compared to CHP. Our goal was to compare chondrogenic differentiation of hASC using a microgravity bioreactor and a hydrostatic pressure vessel, two commonly used bioreactors in cartilage tissue engineering. Our results indicate that CHP promotes hASC chondrogenesis and that microgravity may inhibit hASC chondrogenesis. Our findings further suggest that cartilage formation and regeneration might be compromised in space due to the lack of mechanical loading.Mellor LF, Steward AJ, Nordberg RC, Taylor MA, Loboa EG. Comparison of simulated microgravity and hydrostatic pressure for chondrogenesis of hASC. Aerosp Med Hum Perform. 2017; 88(4):377-384.

  19. Revision of ASCE 4

    International Nuclear Information System (INIS)

    Nelson, T.A.; Murray, R.C.; Short, S.A.

    1995-01-01

    The original version of ASCE Standard 4, ''Seismic Analysis of Safety-Related Nuclear Structures'' was published in September 1986. It is ASCE policy to update its standards on a five year interval and the Working Group on Seismic Analysis of Safety Related Nuclear Structures was reconvened to formulate the revisions. The goal in updating the standard is to make sure that it is still relevant and that it incorporates the state of the practice in seismic engineering or, in some cases, where it has been demonstrated that state-of-the-art improvements need to be made to standard practice; new improvements are included. The contents of the new standard cover the same areas as the original version, with some additions. The contents are as follows: Input - response spectra and time histories; modeling of structures; analysis of structures; soil-structure interaction; input for subsystem analysis; special structures - buried pipes and conduits, earth-retaining walls, above-ground vertical tanks, raceways, and base-isolated structures; and an appendix providing seismic probabilistic risk assessment and margin assessment

  20. Test Hardware Design for Flightlike Operation of Advanced Stirling Convertors (ASC-E3)

    Science.gov (United States)

    Oriti, Salvatore M.

    2012-01-01

    NASA Glenn Research Center (GRC) has been supporting development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG project is providing life, reliability, and performance testing of the Advanced Stirling Convertor (ASC). For this purpose, the Thermal Energy Conversion branch at GRC has been conducting extended operation of a multitude of free-piston Stirling convertors. The goal of this effort is to generate long-term performance data (tens of thousands of hours) simultaneously on multiple units to build a life and reliability database. The test hardware for operation of these convertors was designed to permit in-air investigative testing, such as performance mapping over a range of environmental conditions. With this, there was no requirement to accurately emulate the flight hardware. For the upcoming ASC-E3 units, the decision has been made to assemble the convertors into a flight-like configuration. This means the convertors will be arranged in the dual-opposed configuration in a housing that represents the fit, form, and thermal function of the ASRG. The goal of this effort is to enable system level tests that could not be performed with the traditional test hardware at GRC. This offers the opportunity to perform these system-level tests much earlier in the ASRG flight development, as they would normally not be performed until fabrication of the qualification unit. This paper discusses the requirements, process, and results of this flight-like hardware design activity.

  1. Comparison of lysimeter based and calculated ASCE reference evapotranspiration in a subhumid climate

    Science.gov (United States)

    Nolz, Reinhard; Cepuder, Peter; Eitzinger, Josef

    2016-04-01

    The standardized form of the well-known FAO Penman-Monteith equation, published by the Environmental and Water Resources Institute of the American Society of Civil Engineers (ASCE-EWRI), is recommended as a standard procedure for calculating reference evapotranspiration (ET ref) and subsequently plant water requirements. Applied and validated under different climatic conditions it generally achieved good results compared to other methods. However, several studies documented deviations between measured and calculated reference evapotranspiration depending on environmental and weather conditions. Therefore, it seems generally advisable to evaluate the model under local environmental conditions. In this study, reference evapotranspiration was determined at a subhumid site in northeastern Austria from 2005 to 2010 using a large weighing lysimeter (ET lys). The measured data were compared with ET ref calculations. Daily values differed slightly during a year, at which ET ref was generally overestimated at small values, whereas it was rather underestimated when ET was large, which is supported also by other studies. In our case, advection of sensible heat proved to have an impact, but it could not explain the differences exclusively. Obviously, there were also other influences, such as seasonal varying surface resistance or albedo. Generally, the ASCE-EWRI equation for daily time steps performed best at average weather conditions. The outcomes should help to correctly interpret ET ref data in the region and in similar environments and improve knowledge on the dynamics of influencing factors causing deviations.

  2. William Knocke receives 2008 Virginia Outstanding Civil Engineer Award

    OpenAIRE

    Daniilidi, Christina

    2008-01-01

    William R. Knocke, W.C. English Professor and head of the Charles E. Via, Jr. Department of Civil and Environmental Engineering at Virginia Tech, was awarded the 2008 Virginia Outstanding Civil Engineer Award at the Virginia Section of the American Society of Civil Engineers' (ASCE) banquet, held recently in Williamsburg, Va.

  3. Required number of records for ASCE/SEI 7 ground-motion scaling procedure

    Science.gov (United States)

    Reyes, Juan C.; Kalkan, Erol

    2011-01-01

    The procedures and criteria in 2006 IBC (International Council of Building Officials, 2006) and 2007 CBC (International Council of Building Officials, 2007) for the selection and scaling ground-motions for use in nonlinear response history analysis (RHA) of structures are based on ASCE/SEI 7 provisions (ASCE, 2005, 2010). According to ASCE/SEI 7, earthquake records should be selected from events of magnitudes, fault distance, and source mechanisms that comply with the maximum considered earthquake, and then scaled so that the average value of the 5-percent-damped response spectra for the set of scaled records is not less than the design response spectrum over the period range from 0.2Tn to 1.5Tn sec (where Tn is the fundamental vibration period of the structure). If at least seven ground-motions are analyzed, the design values of engineering demand parameters (EDPs) are taken as the average of the EDPs determined from the analyses. If fewer than seven ground-motions are analyzed, the design values of EDPs are taken as the maximum values of the EDPs. ASCE/SEI 7 requires a minimum of three ground-motions. These limits on the number of records in the ASCE/SEI 7 procedure are based on engineering experience, rather than on a comprehensive evaluation. This study statistically examines the required number of records for the ASCE/SEI 7 procedure, such that the scaled records provide accurate, efficient, and consistent estimates of" true" structural responses. Based on elastic-perfectly-plastic and bilinear single-degree-of-freedom systems, the ASCE/SEI 7 scaling procedure is applied to 480 sets of ground-motions. The number of records in these sets varies from three to ten. The records in each set were selected either (i) randomly, (ii) considering their spectral shapes, or (iii) considering their spectral shapes and design spectral-acceleration value, A(Tn). As compared to benchmark (that is, "true") responses from unscaled records using a larger catalog of ground

  4. ASC deficiency suppresses proliferation and prevents medulloblastoma incidence.

    Science.gov (United States)

    Knight, E R W; Patel, E Y; Flowers, C A; Crowther, A J; Ting, J P; Miller, C R; Gershon, T R; Deshmukh, M

    2015-01-15

    Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is silenced by promoter methylation in many types of tumors, yet ASC's role in most cancers remains unknown. Here, we show that ASC is highly expressed in a model of medulloblastoma, the most common malignant pediatric brain cancer; ASC is also expressed in human medulloblastomas. Importantly, while ASC deficiency did not affect normal cerebellar development, ASC knockout mice on the Smoothened (ND2:SmoA1) transgenic model of medulloblastoma exhibited a profound reduction in medulloblastoma incidence and a delayed tumor onset. A similar decrease in tumorigenesis with ASC deficiency was also seen in the hGFAP-Cre:SmoM2 mouse model of medulloblastoma. Interestingly, hyperproliferation of the external granule layer (EGL) was comparable at P20 in both wild-type and ASC-deficient SmoA1 mice. However, while the apoptosis and differentiation markers remained unchanged at this age, proliferation makers were decreased, and the EGL was reduced in thickness and area by P60. This reduction in proliferation with ASC deficiency was also seen in isolated SmoA1 cerebellar granule precursor cells in vitro, indicating that the effect of ASC deletion on proliferation was cell autonomous. Interestingly, ASC-deficient SmoA1 cerebella exhibited disrupted expression of genes in the transforming growth factor-β pathway and increased level of nuclear Smad3. Taken together, these results demonstrate an unexpected role for ASC in Sonic hedgehog-driven medulloblastoma tumorigenesis, thus identifying ASC as a promising novel target for antitumor therapy.

  5. How many records should be used in ASCE/SEI-7 ground motion scaling procedure?

    Science.gov (United States)

    Reyes, Juan C.; Kalkan, Erol

    2012-01-01

    U.S. national building codes refer to the ASCE/SEI-7 provisions for selecting and scaling ground motions for use in nonlinear response history analysis of structures. Because the limiting values for the number of records in the ASCE/SEI-7 are based on engineering experience, this study examines the required number of records statistically, such that the scaled records provide accurate, efficient, and consistent estimates of “true” structural responses. Based on elastic–perfectly plastic and bilinear single-degree-of-freedom systems, the ASCE/SEI-7 scaling procedure is applied to 480 sets of ground motions; the number of records in these sets varies from three to ten. As compared to benchmark responses, it is demonstrated that the ASCE/SEI-7 scaling procedure is conservative if fewer than seven ground motions are employed. Utilizing seven or more randomly selected records provides more accurate estimate of the responses. Selecting records based on their spectral shape and design spectral acceleration increases the accuracy and efficiency of the procedure.

  6. Probability-Based Design Criteria of the ASCE 7 Tsunami Loads and Effects Provisions (Invited)

    Science.gov (United States)

    Chock, G.

    2013-12-01

    Mitigation of tsunami risk requires a combination of emergency preparedness for evacuation in addition to providing structural resilience of critical facilities, infrastructure, and key resources necessary for immediate response and economic and social recovery. Critical facilities would include emergency response, medical, tsunami refuges and shelters, ports and harbors, lifelines, transportation, telecommunications, power, financial institutions, and major industrial/commercial facilities. The Tsunami Loads and Effects Subcommittee of the ASCE/SEI 7 Standards Committee is developing a proposed new Chapter 6 - Tsunami Loads and Effects for the 2016 edition of the ASCE 7 Standard. ASCE 7 provides the minimum design loads and requirements for structures subject to building codes such as the International Building Code utilized in the USA. In this paper we will provide a review emphasizing the intent of these new code provisions and explain the design methodology. The ASCE 7 provisions for Tsunami Loads and Effects enables a set of analysis and design methodologies that are consistent with performance-based engineering based on probabilistic criteria. . The ASCE 7 Tsunami Loads and Effects chapter will be initially applicable only to the states of Alaska, Washington, Oregon, California, and Hawaii. Ground shaking effects and subsidence from a preceding local offshore Maximum Considered Earthquake will also be considered prior to tsunami arrival for Alaska and states in the Pacific Northwest regions governed by nearby offshore subduction earthquakes. For national tsunami design provisions to achieve a consistent reliability standard of structural performance for community resilience, a new generation of tsunami inundation hazard maps for design is required. The lesson of recent tsunami is that historical records alone do not provide a sufficient measure of the potential heights of future tsunamis. Engineering design must consider the occurrence of events greater than

  7. Authenticated Secure Container System (ASCS)

    International Nuclear Information System (INIS)

    1991-01-01

    Sandia National Laboratories developed an Authenticated Secure Container System (ASCS) for the International Atomic Energy Agency (IAEA). Agency standard weights and safeguards samples can be stored in the ASCS to provide continuity of knowledge. The ASCS consists of an optically clear cover, a base containing the Authenticated Item Monitoring System (AIMS) transmitter, and the AIMS receiver unit for data collection. The ASCS will provide the Inspector with information concerning the status of the system, during a surveillance period, such as state of health, tampering attempts, and movement of the container system. The secure container is located inside a Glove Box with the receiver located remotely from the Glove Box. AIMS technology uses rf transmission from the secure container to the receiver to provide a record of state of health and tampering. The data is stored in the receiver for analysis by the Inspector during a future inspection visit. 2 refs

  8. Ambulatory Surgical Center (ASC) Payment System

    Data.gov (United States)

    U.S. Department of Health & Human Services — This file contains a summary of service utilization by ASC supplier and is derived from 2011 ASC line item level data, updated through June 2012, that is, line items...

  9. Engineering anatomically shaped vascularized bone grafts with hASCs and 3D-printed PCL scaffolds.

    Science.gov (United States)

    Temple, Joshua P; Hutton, Daphne L; Hung, Ben P; Huri, Pinar Yilgor; Cook, Colin A; Kondragunta, Renu; Jia, Xiaofeng; Grayson, Warren L

    2014-12-01

    The treatment of large craniomaxillofacial bone defects is clinically challenging due to the limited availability of transplantable autologous bone grafts and the complex geometry of the bones. The ability to regenerate new bone tissues that faithfully replicate the anatomy would revolutionize treatment options. Advances in the field of bone tissue engineering over the past few decades offer promising new treatment alternatives using biocompatible scaffold materials and autologous cells. This approach combined with recent advances in three-dimensional (3D) printing technologies may soon allow the generation of large, bioartificial bone grafts with custom, patient-specific architecture. In this study, we use a custom-built 3D printer to develop anatomically shaped polycaprolactone (PCL) scaffolds with varying internal porosities. These scaffolds are assessed for their ability to support induction of human adipose-derived stem cells (hASCs) to form vasculature and bone, two essential components of functional bone tissue. The development of functional tissues is assessed in vitro and in vivo. Finally, we demonstrate the ability to print large mandibular and maxillary bone scaffolds that replicate fine details extracted from patient's computed tomography scans. The findings of this study illustrate the capabilities and potential of 3D printed scaffolds to be used for engineering autologous, anatomically shaped, vascularized bone grafts. © 2014 Wiley Periodicals, Inc.

  10. Environmental Engineering in Mining Engineering Education

    Science.gov (United States)

    Mahamud-Lopez, Manuel Maria; Menendez-Aguado, Juan Maria

    2005-01-01

    In this paper, the current profile of the environmental engineer and the programming of the subject "Environmental Engineering and Technology" corresponding to the studies of Mining Engineering at the University of Oviedo in Spain, is discussed. Professional profile, student knowledge prior to and following instruction as well as…

  11. The development of the brake system of the BMW 850i including ABS and ASC. Entwicklung des Bremssystems des BMW 850i einschliesslich ABS und ASC

    Energy Technology Data Exchange (ETDEWEB)

    Kraft, H.J.; Leffler, H.

    1990-02-01

    The brake system of the new BMW 850i is described in the following. The brake actuation takes place via an hydraulic brake booster. The disc brakes at front and rear axle are arranged in diagnonal brake split. The 4-channel ABS is fitted as standard equipment. The ABS control unit also incorporates the algorithm for the Automatic Stability Control System ASC or ASC+T. The ASC+T shows improved traction compared with the pure stability system ASC and is standard in the BMW 850i with manual gear box. The automatic gear box equipped BMW 850i are supplied with ASC, the ASC+T is available as an option. Both systems, the ASC and the ASC+T are described with special view on the electronical and hydraulical network in the car. A performance comparison of the ASC-systems completes the description. (orig.).

  12. Advanced Stirling Convertor (ASC) Technology Maturation in Preparation for Flight

    Science.gov (United States)

    Wong, Wayne A.; Cornell, Peggy A.

    2012-01-01

    The Advanced Stirling Convertor (ASC) is being developed by an integrated team of Sunpower and National Aeronautics and Space Administration s (NASA s) Glenn Research Center (GRC). The ASC development, funded by NASA s Science Mission Directorate, started as a technology development effort in 2003 and has since evolved through progressive convertor builds and successful testing to demonstrate high conversion efficiency, low mass, and capability to meet long-life Radioisotope Power System (RPS) requirements. The technology has been adopted by the Department of Energy and Lockheed Martin Space Systems Company s Advanced Stirling Radioisotope Generator (ASRG), which has been selected for potential flight demonstration on Discovery 12. This paper provides an overview of the status of ASC development including the most recent ASC-E2 convertors that have been delivered to GRC and an introduction to the ASC-E3 and ASC flight convertors that Sunpower will build next. The paper also describes the technology maturation and support tasks being conducted at GRC to support ASC and ASRG development in the areas of convertor and generator extended operation, high-temperature materials, heater head life assessment, organics, nondestructive inspection, spring fatigue testing, and other reliability verification tasks.

  13. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2006-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention......-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental Engineering, thus, in essence...... comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual disciplines, within each...

  14. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2004-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention...... of Eco-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental...... Engineering, thus, in essence comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual...

  15. Introduction to environmental engineering

    Science.gov (United States)

    Šalić, Anita; Zelić, Bruno

    2018-02-01

    Nowadays we can easily say that environmental engineering is truly an interdisciplinary science. Combining biology, ecology, geology, geography, mathematics, chemistry, agronomy, medicine, economy, etc. environmental engineering strives to use environmental understanding and advancements in technology to serve mankind by decreasing production of environmental hazards and the effects of those hazards already present in the soil, water, and air. Major activities of environmental engineer involve water supply, waste water and solid management, air and noise pollution control, environmental sustainability, environmental impact assessment, climate changes, etc. And all this with only one main goal - to prevent or reduce undesirable impacts of human activities on the environment. To ensure we all have tomorrow.

  16. American Society of Civil Engineers | ASCE

    Science.gov (United States)

    Membership Your New Membership: Getting Started Member Value Civil Engineering Salaries Manage Your Account Vote Now Education & Careers Training & Courses Getting Licensed & Certified Live Exam Reviews Specialty Certifications Civil Engineering Body of Knowledge Volunteer Opportunities Jobs Ethics

  17. Trends in Environmental Health Engineering

    Science.gov (United States)

    Rowe, D. R.

    1972-01-01

    Reviews the trends in environmental health engineering and describes programs in environmental engineering technology and the associated environmental engineering courses at Western Kentucky University (four-year program), Wytheville Community College (two-year program), and Rensselaer Polytechnic Institute (four-year program). (PR)

  18. MRI-tracking of transplanted human ASC in a SCID mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Siegmund, Birte J.; Kasten, Annika [Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical Center (Germany); Kühn, Jens-Peter [Institute of Diagnostic Radiology and Neuroradiology, Greifswald University Medical Center (Germany); Winter, Karsten [Institute of Anatomy, Faculty of Medicine, University of Leipzig (Germany); Grüttner, Cordula [Micromod Partikeltechnologie GmbH, Rostock (Germany); Frerich, Bernhard, E-mail: bernhard.frerich@med.uni-rostock.de [Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical Center (Germany)

    2017-04-01

    Background: Regarding strategies improving the efficacy of stem cell transplantation in adipose tissue engineering, cell tracking might be useful. Here we report the in vivo tracking of adipose tissue derived stem cells (ASC) by means of nanoparticle labeling and magnetic resonance imaging (MRI). Here we report the in vivo tracking of adipose tissue derived stromal cells (ASC) by means of nanoparticle labeling and magnetic resonance imaging (MRI). Materials and methods: Human ASC were amplified and labeled with two types of magnetic nanoparticles (MNP), BNF starch and nanomag®-D-spio. Adipose tissue constructs were fabricated by seeding collagen scaffolds with labeled and unlabeled ASCs. Constructs were implanted subcutaneously in the back of severe combined immunodeficient (SCID) mice (n =69, group 1: control with cells w/o label, group 2: BNF starch labeled cells, group 3: nanomag®-D-spio labeled cells). MRI scans were performed at 24 hours, four, twelve and 28 days and four months in a 7.1 T animal device. Explanted constructs were analyzed histomorphometrically. Results: MRI scans showed high contrast of the labeled cells in t2-tse-sequence compared to unlabeled controls. Loss of volume of the implants was observed over time due to partial loss for transplanted cells without significant difference (level of significance p<0.017). Compared to histomorphometry, there was found a positiv correlations in measurement of implant size with a significant at day four (correlation coefficient =0.643; p=0.024) and day twelve (correlation coefficient =0.687; p=0.010). Additional Prussian blue stain showed iron in all implants. Significant differences between the three groups (significance level p<0.017) were found after twelve days between control group and group 3 (p=0.008) and after 28 days between control group and group 2 and 3 (p=0.011). Conclusion: Both MNPs might be suitable for tracking of ASC in vivo and show long term stability over 4 months. - Highlights:

  19. Antiproliferative effect of ASC-J9 delivered by PLGA nanoparticles against estrogen-dependent breast cancer cells.

    Science.gov (United States)

    Verderio, Paolo; Pandolfi, Laura; Mazzucchelli, Serena; Marinozzi, Maria Rosaria; Vanna, Renzo; Gramatica, Furio; Corsi, Fabio; Colombo, Miriam; Morasso, Carlo; Prosperi, Davide

    2014-08-04

    Among polymeric nanoparticles designed for cancer therapy, PLGA nanoparticles have become one of the most popular polymeric devices for chemotherapeutic-based nanoformulations against several kinds of malignant diseases. Promising properties, including long-circulation time, enhanced tumor localization, interference with "multidrug" resistance effects, and environmental biodegradability, often result in an improvement of the drug bioavailability and effectiveness. In the present work, we have synthesized 1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one (ASC-J9) and developed uniform ASC-J9-loaded PLGA nanoparticles of about 120 nm, which have been prepared by a single-emulsion process. Structural and morphological features of the nanoformulation were analyzed, followed by an accurate evaluation of the in vitro drug release kinetics, which exhibited Fickian law diffusion over 10 days. The intracellular degradation of ASC-J9-bearing nanoparticles within estrogen-dependent MCF-7 breast cancer cells was correlated to a time- and dose-dependent activity of the released drug. A cellular growth inhibition associated with a specific cell cycle G2/M blocking effect caused by ASC-J9 release inside the cytosol allowed us to put forward a hypothesis on the action mechanism of this nanosystem, which led to the final cell apoptosis. Our study was accomplished using Annexin V-based cell death analysis, MTT assessment of proliferation, radical scavenging activity, and intracellular ROS evaluation. Moreover, the intracellular localization of nanoformulated ASC-J9 was confirmed by a Raman optical imaging experiment designed ad hoc. PLGA nanoparticles and ASC-J9 proved also to be safe for a healthy embryo fibroblast cell line (3T3-L1), suggesting a possible clinical translation of this potential nanochemotherapeutic to expand the inherently poor bioavailability of hydrophobic ASC-J9 that could be proposed for the treatment of malignant breast cancer.

  20. The Astrobiology in Secondary Classrooms (ASC) curriculum: focusing upon diverse students and teachers.

    Science.gov (United States)

    Arino de la Rubia, Leigh S

    2012-09-01

    The Minority Institution Astrobiology Collaborative (MIAC) began working with the NASA Goddard Center for Astrobiology in 2003 to develop curriculum materials for high school chemistry and Earth science classes based on astrobiology concepts. The Astrobiology in Secondary Classrooms (ASC) modules emphasize interdisciplinary connections in astronomy, biology, chemistry, geoscience, physics, mathematics, and ethics through hands-on activities that address national educational standards. Field-testing of the Astrobiology in Secondary Classrooms materials occurred over three years in eight U.S. locations, each with populations that are underrepresented in the career fields of science, technology, engineering, and mathematics. Analysis of the educational research upon the high school students participating in the ASC project showed statistically significant increases in students' perceived knowledge and science reasoning. The curriculum is in its final stages, preparing for review to become a NASA educational product.

  1. Environmental, safety, and health engineering

    International Nuclear Information System (INIS)

    Woodside, G.; Kocurek, D.

    1997-01-01

    A complete guide to environmental, safety, and health engineering, including an overview of EPA and OSHA regulations; principles of environmental engineering, including pollution prevention, waste and wastewater treatment and disposal, environmental statistics, air emissions and abatement engineering, and hazardous waste storage and containment; principles of safety engineering, including safety management, equipment safety, fire and life safety, process and system safety, confined space safety, and construction safety; and principles of industrial hygiene/occupational health engineering including chemical hazard assessment, personal protective equipment, industrial ventilation, ionizing and nonionizing radiation, noise, and ergonomics

  2. Environmental Engineering in the Slovak Republic

    Science.gov (United States)

    Stevulova, N.; Balintova, M.; Zelenakova, M.; Estokova, A.; Vilcekova, S.

    2017-10-01

    The fundamental role of environmental engineering is to protect human population and environment from impacts of human activities and to ensure environmental quality. It relates to achieving the environmental sustainability goals through advanced technologies for pollutants removing from air, water and soil in order to minimize risk in ecosystem and ensuring favourable conditions for life of humans and organisms. Nowadays, a critical analysis of the environment quality and innovative approaches to problem solving in order to achieve sustainability in environmental engineering, are necessary. This article presents an overview of the quality of the environment and progress in environmental engineering in Slovakia and gives information regarding the environmental engineering education at Faculty of Civil Engineering at Technical University in Kosice.

  3. Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion

    Directory of Open Access Journals (Sweden)

    Zeynep Tosuner

    2017-01-01

    Full Text Available Aims: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A and minichromosome maintenance protein 2 (MCM2 in abnormal interpreted smears. Settings and Design: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions. ProEx C for topoisomerase II alpha (TOP2A and minichromosome maintenance protein 2 (MCM2 has been considered to have tight association with high grade intraepithelial lesions. Materials and Methods: A total number of 54 SurePath cervical cytology specimens of patients previously interpreted as atypical squamous cells-undetermined significance (ASC-US, atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion (ASC-H, low grade squamous intraepithelial lesion (LSIL, and high grade squamous intraepithelial lesion (HSIL were included in our study. Results and Conclusions: ProEx C was positive in 14 of HSILs (100%, 3 of 19 LSILs (16%, 2 of 4 ASC-Hs, and none of ASC-USs (0%. The ProEx C test showed very intense nuclear staining in all cytologically abnormal cells. Further studies are indicated to evaluate the diagnostic role of ProEx C.

  4. Engineering for Sustainable Development and the Common Good

    Science.gov (United States)

    Kelly, William E.

    2006-01-01

    In 1994, the American Society of Civil Engineers (ASCE) updated its Code of Ethics to include specific statements on sustainable development and at about the same time, 1994, ASCE adopted its Policy 418 on sustainable development. Sustainable development as defined by ASCE "is the challenge of meeting human needs for natural resources, industrial…

  5. Information technologies in environmental engineering. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Athanasiadis, Ioannis N.; Rizzoli, Andrea E. [Istituto dalle Molle di Studi sull' Intelligenza Artificiale (IDSIA), Manno (Switzerland); Mitkas, Pericles A. [Aristotle Univ. of Thessaloniki (Greece); Marx Gomez, Jorge (eds.) [Oldenburg Univ. (Germany). Abt. Wirtschaftsinformatik

    2009-07-01

    Information technologies have evolved to an enabling science for natural resource management and conservation, environmental engineering, scientific simulation and integrated assessment studies. Computing plays a significant role in every day practices of environmental engineers, natural scientists, economists, and social scientists. The complexity of natural phenomena requires interdisciplinary approaches, where computing science offers the infrastructure for environmental data collection and management, scientific simulations, decision support documentation and reporting. Ecology, environmental engineering and natural resource management comprise an excellent real-world testbed for IT system demonstration, while raising new challenges for computer science. Complexity, uncertainty and scaling issues of natural systems form a demanding application domain for sensor networks and earth observation systems; modelling, simulation and scientific workflows, data management and reporting, decision support and intelligent systems, distributed computing environments, geographical information systems, heterogeneous systems integration, software engineering, accounting systems and control systems. This books offers a collection of papers presented at the 4th International Symposium on Environmental Engineering, held in May 2009, in Thessaloniki, Greece. Recent success stories in ecoinformatics, promising ideas and new challenges are discussed among computer scientists, environmental engineers, economists and social scientists, demonstrating new paradigms for problem solving and decision making. (orig.)

  6. Health effects engineering: Perspectives for environmental health and environmental engineering studies-domestic biomass combustion as an example

    International Nuclear Information System (INIS)

    Gao Xiang; Yu Qi; Chen Limin

    2007-01-01

    Health effects engineering (HEE) is a newly developed research field, which involves collaboration with environmental scientists, engineering researchers, and toxicologists. By employing the methods of HEE, one can not only confirm which attributes of the project are likely to contribute to certain health effects, but can also get rid of the adverse health effects by engineering technologies. HEE is thought to be particularly important to domestic projects in which there is a lack of environmental assessment. This paper presented the authors' viewpoints of the principles of HEE in the field of the environmental health and engineering studies by using programs of domestic biomass combustion as an example. The authors showed that there are three sub-fields of HEE, which are as follows: engineering behavior, the pollution characteristics, and the health effects. The authors conclude that the principles of HEE compose a helix with the studies in the fields of environmental science, health, and engineering, and give suggestions on how to perform HEE in a practical field

  7. Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC regulates inflammasomes

    Directory of Open Access Journals (Sweden)

    Rojanasakul Yon

    2010-05-01

    Full Text Available Abstract Background The apoptotic speck-like protein containing a caspase recruitment domain (ASC is the essential adaptor protein for caspase 1 mediated interleukin (IL-1β and IL-18 processing in inflammasomes. It bridges activated Nod like receptors (NLRs, which are a family of cytosolic pattern recognition receptors of the innate immune system, with caspase 1, resulting in caspase 1 activation and subsequent processing of caspase 1 substrates. Hence, macrophages from ASC deficient mice are impaired in their ability to produce bioactive IL-1β. Furthermore, we recently showed that ASC translocates from the nucleus to the cytosol in response to inflammatory stimulation in order to promote an inflammasome response, which triggers IL-1β processing and secretion. However, the precise regulation of inflammasomes at the level of ASC is still not completely understood. In this study we identified and characterized three novel ASC isoforms for their ability to function as an inflammasome adaptor. Methods To establish the ability of ASC and ASC isoforms as functional inflammasome adaptors, IL-1β processing and secretion was investigated by ELISA in inflammasome reconstitution assays, stable expression in THP-1 and J774A1 cells, and by restoring the lack of endogenous ASC in mouse RAW264.7 macrophages. In addition, the localization of ASC and ASC isoforms was determined by immunofluorescence staining. Results The three novel ASC isoforms, ASC-b, ASC-c and ASC-d display unique and distinct capabilities to each other and to full length ASC in respect to their function as an inflammasome adaptor, with one of the isoforms even showing an inhibitory effect. Consistently, only the activating isoforms of ASC, ASC and ASC-b, co-localized with NLRP3 and caspase 1, while the inhibitory isoform ASC-c, co-localized only with caspase 1, but not with NLRP3. ASC-d did not co-localize with NLRP3 or with caspase 1 and consistently lacked the ability to function as an

  8. ASC FY17 Implementation Plan, Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, P. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-06-14

    The Stockpile Stewardship Program (SSP) is an integrated technical program for maintaining the safety, surety, and reliability of the U.S. nuclear stockpile. The SSP uses nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of experimental facilities and programs, and the computational capabilities to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources that support annual stockpile assessment and certification, study advanced nuclear weapons design and manufacturing processes, analyze accident scenarios and weapons aging, and provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balance of resources, including technical staff, hardware, simulation software, and computer science solutions.

  9. Dimorfismo de ascósporos em Glomerella cingulata f.sp. phaseoli

    OpenAIRE

    Castro, Renata A.; Mendes-Costa, Maria C.; Souza, Elaine A.

    2006-01-01

    O objetivo deste trabalho foi caracterizar linhagens de Glomerella cingulata f. sp. phaseoli quanto ao crescimento micelial, formação de peritécio e dimorfismo de ascósporos. Foram avaliadas quatro linhagens nos meios de cultura de folhas de feijoeiro e meio M3 e em condições com e sem fotoperíodo. O comprimento dos ascósporos da linhagem normal e da mutante foi determinado. Houve diferença significativa quanto ao crescimento micelial e tamanho dos ascósporos. Constatou-se, pela primeira vez,...

  10. USDA-ASCS 1936-1939 Air Photos

    Data.gov (United States)

    Minnesota Department of Natural Resources — This data set is a digital version of aerial photographs taken during the 1936-1939 time frame for the USDA-ASCS. These photos were originally recorded at a scale of...

  11. The AscSimulationMode command

    DEFF Research Database (Denmark)

    Jørgensen, John Leif

    1998-01-01

    Complex instruments like the ASC may be quite difficult to test in closed loops. This problem is augmented by the fact, that no direct stimulation of the CHU is possible that will render the full performance, noise-spectrum and real-timeliness with high fidelity. In order to circumvent this impasse...

  12. Environmental Ethics and Civil Engineering.

    Science.gov (United States)

    Vesilind, P. Aarne

    1987-01-01

    Traces the development of the civil engineering code of ethics. Points out that the code does have an enforceable provision that addresses the engineer's responsibility toward the environment. Suggests revisions to the code to accommodate the environmental impacts of civil engineering. (TW)

  13. Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.

    Science.gov (United States)

    Cero, Fadila Telarevic; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine; Lunde, Ida Gjervold; Olsen, Maria Belland; Lien, Egil; Zhang, Lili; Haugstad, Solveig Bjærum; Løberg, Else Marit; Christensen, Geir; Larsen, Karl-Otto; Skjønsberg, Ole Henning

    2015-08-15

    Pulmonary hypertension is a serious condition that can lead to premature death. The mechanisms involved are incompletely understood although a role for the immune system has been suggested. Inflammasomes are part of the innate immune system and consist of the effector caspase-1 and a receptor, where nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3) is the best characterized and interacts with the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC). To investigate whether ASC and NLRP3 inflammasome components are involved in hypoxia-induced pulmonary hypertension, we utilized mice deficient in ASC and NLRP3. Active caspase-1, IL-18, and IL-1β, which are regulated by inflammasomes, were measured in lung homogenates in wild-type (WT), ASC(-/-), and NLRP3(-/-) mice, and phenotypical changes related to pulmonary hypertension and right ventricular remodeling were characterized after hypoxic exposure. Right ventricular systolic pressure (RVSP) of ASC(-/-) mice was significantly lower than in WT exposed to hypoxia (40.8 ± 1.5 mmHg vs. 55.8 ± 2.4 mmHg, P right ventricular remodeling. RVSP of NLRP3(-/-) mice exposed to hypoxia was not significantly altered compared with WT hypoxia. Whereas hypoxia increased protein levels of caspase-1, IL-18, and IL-1β in WT and NLRP3(-/-) mice, this response was absent in ASC(-/-) mice. Moreover, ASC(-/-) mice displayed reduced muscularization and collagen deposition around arteries. In conclusion, hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC, suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension. Copyright © 2015 the American Physiological Society.

  14. Environmental Engineering and Sustainable Development

    OpenAIRE

    Said Salah Eldin Elnashaie

    2018-01-01

    Chemical Engineering is a very rich discipline and it is best classified using System Theory (ST) and utilized using the Integrated System Approach (ISA). Environmental Engineering (EE) is a subsystem of Chemical Engineering and also a subsystem of Sustainable Development (SD). In this paper both EE and SD are discussed from a Chemical Engineering point of view utilizing ST and ISA.

  15. Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC.

    Science.gov (United States)

    Gambin, Yann; Giles, Nichole; O'Carroll, Ailís; Polinkovsky, Mark; Hunter, Dominic; Sierecki, Emma

    2018-02-16

    Single-molecule fluorescence has the unique ability to quantify small oligomers and track conformational changes at a single-protein level. Here we tackled one of the most extreme protein behaviors, found recently in an inflammation pathway. Upon danger recognition in the cytosol, NLRP3 recruits its signaling adaptor, ASC. ASC start polymerizing in a prion-like manner and the system goes in "overdrive" by producing a single micron-sized "speck." By precisely controlling protein expression levels in an in vitro translation system, we could trigger the polymerization of ASC and mimic formation of specks in the absence of inflammasome nucleators. We utilized single-molecule spectroscopy to fully characterize prion-like behaviors and self-propagation of ASC fibrils. We next used our controlled system to monitor the conformational changes of ASC upon fibrillation. Indeed, ASC consists of a PYD and CARD domains, separated by a flexible linker. Individually, both domains have been found to form fibrils, but the structure of the polymers formed by the full-length ASC proteins remains elusive. For the first time, using single-molecule Förster resonance energy transfer, we studied the relative positions of the CARD and PYD domains of full-length ASC. An unexpectedly large conformational change occurred upon ASC fibrillation, suggesting that the CARD domain folds back onto the PYD domain. However, contradicting current models, the "prion-like" conformer was not initiated by binding of ASC to the NLRP3 platform. Rather, using a new method, hybrid between Photon Counting Histogram and Number and Brightness analysis, we showed that NLRP3 forms hexamers with self-binding affinities around 300nM. Overall our data suggest a new mechanism, where NLRP3 can initiate ASC polymerization simply by increasing the local concentration of ASC above a supercritical level. Copyright © 2017. Published by Elsevier Ltd.

  16. Environmental Engineering Curricula assessment in the global world

    Science.gov (United States)

    Caporali, Enrica; Catelani, Marcantonio; Manfrida, Giampaolo; Valdiserri, Juna

    2014-05-01

    Environmental engineers are technicians with specific expertise on the sustainability of human presence in the environment. Among other global dilemmas, to the environmental engineers it is often demanded to be able in developing systematic, innovative solutions in order to simultaneously meet water and energy needs, to build resilience to natural and technological disasters, to more accurately gauge and manage countries' greenhouse gas emissions. The general objectives of the Environmental Engineers are to establish actions of environmental sustainability as well as to verify progress toward global goals or international commitments. The globalization of challenges and problems to be faced, leads, in general, to the globalization of the engineering profession. In particular, since the environmental issues are without boundaries, and many and different are the involved professions and the competences, the environmental engineer must have a multidisciplinary and interdisciplinary approach to adequately answer to the demand of technical innovative knowledge at global scale. The environmental engineers, more and more, are involved in international projects were the effective collaboration requires not only the capacity to communicate in a common technical language, but also the assurance of an adequate and common level of technical competences, knowledge and understanding. The Europe-based EUR ACE system, currently operated by ENAEE - European Network for Accreditation of Engineering Education, can represent the proper framework and accreditation system in order to provide a set of measures to assess the quality of engineering degree programmes in Europe and abroad. In the global frame of the knowledge triangle: education-innovation-research, the accreditation and quality assurance of engineering curricula in Europe is discussed with reference to the Environmental engineering curricula, of the 1st and 2nd cycle, based on the European Credit Transfer System and in

  17. General Model Study of Scour at Proposed Pier Extensions - Santa Ana River at BNSF Bridge, Corona, California

    Science.gov (United States)

    2017-11-01

    nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and military engineering , geospatial sciences...around bridge piers.” Journal of the Hydraulics Division, Proceedings of the American Society of Civil Engineers , ASCE 95(6): 1919–1940. Vanoni, V. A...2006. Sedimentation Engineering . ASCE Manuals and Reports on Engineering Practice No. 54. Reston, VA: American Society of Civil Engineers . http

  18. The effect of magnetic stimulation on the osteogenic and chondrogenic differentiation of human stem cells derived from the adipose tissue (hASCs)

    Science.gov (United States)

    Lima, João; Gonçalves, Ana I.; Rodrigues, Márcia T.; Reis, Rui L.; Gomes, Manuela E.

    2015-11-01

    The use of magnetic nanoparticles (MNPs) towards the musculoskeletal tissues has been the focus of many studies, regarding MNPs ability to promote and direct cellular stimulation and orient tissue responses. This is thought to be mainly achieved by mechano-responsive pathways, which can induce changes in cell behavior, including the processes of proliferation and differentiation, in response to external mechanical stimuli. Thus, the application of MNP-based strategies in tissue engineering may hold potential to propose novel solutions for cell therapy on bone and cartilage strategies to accomplish tissue regeneration. The present work aims at studying the influence of MNPs on the osteogenic and chondrogenic differentiation of human adipose derived stem cells (hASCs). MNPs were incorporated in hASCs and cultured in medium supplemented for osteogenic and chondrogenic differentiation. Cultures were maintained up to 28 days with/without an external magnetic stimulus provided by a magnetic bioreactor, to determine if the MNPs alone could affect the osteogenic or chondrogenic phenotype of the hASCs. Results indicate that the incorporation of MNPs does not negatively affect the viability nor the proliferation of hASCs. Furthermore, Alizarin Red staining evidences an enhancement in extracellular (ECM) mineralization under the influence of an external magnetic field. Although not as evident as for osteogenic differentiation, Toluidine blue and Safranin-O stainings also suggest the presence of a cartilage-like ECM with glycosaminoglycans and proteoglycans under the magnetic stimulus provided. Thus, MNPs incorporated in hASCs under the influence of an external magnetic field have the potential to induce differentiation towards the osteogenic and chondrogenic lineages.

  19. Predicting on-site environmental impacts of municipal engineering works

    International Nuclear Information System (INIS)

    Gangolells, Marta; Casals, Miquel; Forcada, Núria; Macarulla, Marcel

    2014-01-01

    The research findings fill a gap in the body of knowledge by presenting an effective way to evaluate the significance of on-site environmental impacts of municipal engineering works prior to the construction stage. First, 42 on-site environmental impacts of municipal engineering works were identified by means of a process-oriented approach. Then, 46 indicators and their corresponding significance limits were determined on the basis of a statistical analysis of 25 new-build and remodelling municipal engineering projects. In order to ensure the objectivity of the assessment process, direct and indirect indicators were always based on quantitative data from the municipal engineering project documents. Finally, two case studies were analysed and found to illustrate the practical use of the proposed model. The model highlights the significant environmental impacts of a particular municipal engineering project prior to the construction stage. Consequently, preventive actions can be planned and implemented during on-site activities. The results of the model also allow a comparison of proposed municipal engineering projects and alternatives with respect to the overall on-site environmental impact and the absolute importance of a particular environmental aspect. These findings are useful within the framework of the environmental impact assessment process, as they help to improve the identification and evaluation of on-site environmental aspects of municipal engineering works. The findings may also be of use to construction companies that are willing to implement an environmental management system or simply wish to improve on-site environmental performance in municipal engineering projects. -- Highlights: • We present a model to predict the environmental impacts of municipal engineering works. • It highlights significant on-site environmental impacts prior to the construction stage. • Findings are useful within the environmental impact assessment process. • They also

  20. Predicting on-site environmental impacts of municipal engineering works

    Energy Technology Data Exchange (ETDEWEB)

    Gangolells, Marta, E-mail: marta.gangolells@upc.edu; Casals, Miquel, E-mail: miquel.casals@upc.edu; Forcada, Núria, E-mail: nuria.forcada@upc.edu; Macarulla, Marcel, E-mail: marcel.macarulla@upc.edu

    2014-01-15

    The research findings fill a gap in the body of knowledge by presenting an effective way to evaluate the significance of on-site environmental impacts of municipal engineering works prior to the construction stage. First, 42 on-site environmental impacts of municipal engineering works were identified by means of a process-oriented approach. Then, 46 indicators and their corresponding significance limits were determined on the basis of a statistical analysis of 25 new-build and remodelling municipal engineering projects. In order to ensure the objectivity of the assessment process, direct and indirect indicators were always based on quantitative data from the municipal engineering project documents. Finally, two case studies were analysed and found to illustrate the practical use of the proposed model. The model highlights the significant environmental impacts of a particular municipal engineering project prior to the construction stage. Consequently, preventive actions can be planned and implemented during on-site activities. The results of the model also allow a comparison of proposed municipal engineering projects and alternatives with respect to the overall on-site environmental impact and the absolute importance of a particular environmental aspect. These findings are useful within the framework of the environmental impact assessment process, as they help to improve the identification and evaluation of on-site environmental aspects of municipal engineering works. The findings may also be of use to construction companies that are willing to implement an environmental management system or simply wish to improve on-site environmental performance in municipal engineering projects. -- Highlights: • We present a model to predict the environmental impacts of municipal engineering works. • It highlights significant on-site environmental impacts prior to the construction stage. • Findings are useful within the environmental impact assessment process. • They also

  1. Advanced Stirling Radioisotope Generator Engineering Unit 2 Anomaly Investigation

    Science.gov (United States)

    Lewandowski, Edward J.; Dobbs, Michael W.; Oriti, Salvatore M.

    2018-01-01

    The Advanced Stirling Radioisotope Generator (ASRG) Engineering Unit 2 (EU2) is the highest fidelity electrically heated Stirling radioisotope generator built to date. NASA Glenn Research Center completed the assembly of the ASRG EU2 in September 2014 using hardware from the now cancelled ASRG flight development project. The ASRG EU2 integrated the first pair of Sunpower's Advanced Stirling Convertors (ASC-E3 #1 and #2) in an aluminum generator housing with Lockheed Martin's (LM's) Engineering Development Unit (EDU) 4 controller. After just 179 hr of EU2 generator operation, the first power fluctuation occurred on ASC-E3 #1. The first power fluctuation occurred 175 hr later on ASC-E3 #2. Over time, the power fluctuations became more frequent on both convertors and larger in magnitude. Eventually the EU2 was shut down in January 2015. An anomaly investigation was chartered to determine root cause of the power fluctuations and other anomalous observations. A team with members from Glenn, Sunpower, and LM conducted a thorough investigation of the EU2 anomalies. Findings from the EU2 disassembly identified proximate causes of the anomalous observations. Discussion of the team's assessment of the primary possible failure theories, root cause, and conclusions is provided. Recommendations are made for future Stirling generator development to address the findings from the anomaly investigation. Additional findings from the investigation are also discussed.

  2. THERMODYNAMICS USED IN ENVIRONMENTAL ENGINEERING

    Science.gov (United States)

    Thermodynamics is a science in which energy transformations are studied as well as their relationships to the changes in the chemical properties of a system. It is the fundamental basis of many engineering fields. The profession of environmental engineering is no exception. In pa...

  3. Environmental Restoration Project - Systems Engineering Management Plan

    International Nuclear Information System (INIS)

    Anderson, T.D.

    1998-06-01

    This Environmental Restoration (ER) Project Systems Engineering Management Plan (SEMP) describes relevant Environmental Restoration Contractor (ERC) management processes and shows how they implement systems engineering. The objective of this SEMP is to explain and demonstrate how systems engineering is being approached and implemented in the ER Project. The application of systems engineering appropriate to the general nature and scope of the project is summarized in Section 2.0. The basic ER Project management approach is described in Section 3.0. The interrelation and integration of project practices and systems engineering are outlined in Section 4.0. Integration with sitewide systems engineering under the Project Hanford Management Contract is described in Section 5.0

  4. Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

    Science.gov (United States)

    Sborgi, Lorenzo; Ravotti, Francesco; Dandey, Venkata P.; Dick, Mathias S.; Mazur, Adam; Reckel, Sina; Chami, Mohamed; Scherer, Sebastian; Huber, Matthias; Böckmann, Anja; Egelman, Edward H.; Stahlberg, Henning; Broz, Petr; Meier, Beat H.; Hiller, Sebastian

    2015-01-01

    Inflammasomes are multiprotein complexes that control the innate immune response by activating caspase-1, thus promoting the secretion of cytokines in response to invading pathogens and endogenous triggers. Assembly of inflammasomes is induced by activation of a receptor protein. Many inflammasome receptors require the adapter protein ASC [apoptosis-associated speck-like protein containing a caspase-recruitment domain (CARD)], which consists of two domains, the N-terminal pyrin domain (PYD) and the C-terminal CARD. Upon activation, ASC forms large oligomeric filaments, which facilitate procaspase-1 recruitment. Here, we characterize the structure and filament formation of mouse ASC in vitro at atomic resolution. Information from cryo-electron microscopy and solid-state NMR spectroscopy is combined in a single structure calculation to obtain the atomic-resolution structure of the ASC filament. Perturbations of NMR resonances upon filament formation monitor the specific binding interfaces of ASC-PYD association. Importantly, NMR experiments show the rigidity of the PYD forming the core of the filament as well as the high mobility of the CARD relative to this core. The findings are validated by structure-based mutagenesis experiments in cultured macrophages. The 3D structure of the mouse ASC-PYD filament is highly similar to the recently determined human ASC-PYD filament, suggesting evolutionary conservation of ASC-dependent inflammasome mechanisms. PMID:26464513

  5. Using Notable Women in Environmental Engineering to Dispel Misperceptions of Engineers

    Science.gov (United States)

    Hoh, Yin Kiong

    2009-01-01

    This paper describes an activity the author has carried out with 72 high school science teachers to enable them to overcome their stereotypical perceptions of engineers. The activity introduced them to notable women in environmental engineering, and raised their awareness of these female engineers' contributions to engineering and society. The…

  6. Yearbook of environmental and engineering law 1990

    International Nuclear Information System (INIS)

    Marburger, P.

    1990-01-01

    The yearbook 1990 again contains individual contributions on German, foreign, and international environmental and engineering law. Beginning with this volume, there will always be a detailed report on previous year developments in environmental and engineering law in order to master the continuously increasing legal material. Some contributions - there are others - deal with the following subjects: Legislative need to act in matters of genetic engineering; ethics commissions and constitutional law; nature's own rights; legal protection of local government against brown coal plans; mining laws; sports and air-traffic noise; questions of nuclear waste management; removal of long-standing multi-party liability in environmental law; waste and restoration of abandoned industrial sites; technological development and liability insurance; problems of legislation coming into effect in pollution abatement procedures; Dutch air pollution abatement fund; environmental absolute liability in Austria; EC environmental legislation and solo actions by individual member states. (HSCH) [de

  7. A global study of undergraduate environmental engineering programs

    International Nuclear Information System (INIS)

    Abro, Q.M.

    2005-01-01

    Recent analyses of environmental engineering and management (EE and M) field has highlighted its rapidly expanding size and increasingly diverse nature (Hart and Nolan, 1999). The last 30 years have seen growing international recognition that the challenges associated with environmental degradation and sustainable development have important implications for, and connections with, education and research (IUCN, 1970; UNCED, 1992). The concept of environmental education is now widespread in national educational policies, curriculum documents, curriculum development initiatives, and conservation strategies. Reflecting this trend, several universities throughout the world offer a wide range of graduate as well as undergraduate programs in environment. These programs have originated from various academic schools and disciplines (engineering, public policy, business, management, etc) creating considerable diversity of focus, themes emphasized, courses and methods of offerings. The rise of these programs, in part, reflects the growing need for engineers, technologists as well as managers, who are able to understand, contribute to, and manage a wide variety of technology-based programs and organizations. In addition, the large number of environmental engineering research journals, professional associations and international/national conferences point to the rapid growth of this field. This paper will examine the trends in provision, type of program, major curriculum focus of undergraduate environmental engineering and management education and then compare these trends with the emerging trends in the environmental engineering and management research journals of the last decade. (author)

  8. Environmental and waste disposal options in nuclear engineering curricula

    International Nuclear Information System (INIS)

    Elleman, T.S.; Gilligan, J.G.

    1991-01-01

    The strong national emphasis on waste and environmental issues has prompted increasing interest among nuclear engineering students in study options that will prepare them for careers in these areas. Student interest appears to focus principally on health physics, radioactive waste disposal, and environmental interactions with radionuclides. One motivation for this interest appears to be the growing national programs in environmental restoration and waste remediation that have produced fellowship support for nuclear engineering students as well as employment opportunities. Also, the recent National Academy of sciences study on nuclear engineering education specifically emphasized the importance of expanding nuclear engineering curricula and research programs to include a greater emphasis on radioactive waste and environmental issues. The North Carolina State University (NCSU) Department of Nuclear Engineering is attempting to respond to these needs through the development of course options that will allow students to acquire background in environmental subjects as a complement to the traditional nuclear engineering education

  9. Environmental engineering education: examples of accreditation and quality assurance

    Science.gov (United States)

    Caporali, E.; Catelani, M.; Manfrida, G.; Valdiserri, J.

    2013-12-01

    Environmental engineers respond to the challenges posed by a growing population, intensifying land-use pressures, natural resources exploitation as well as rapidly evolving technology. The environmental engineer must develop technically sound solutions within the framework of maintaining or improving environmental quality, complying with public policy, and optimizing the utilization of resources. The engineer provides system and component design, serves as a technical advisor in policy making and legal deliberations, develops management schemes for resources, and provides technical evaluations of systems. Through the current work of environmental engineers, individuals and businesses are able to understand how to coordinate society's interaction with the environment. There will always be a need for engineers who are able to integrate the latest technologies into systems to respond to the needs for food and energy while protecting natural resources. In general, the environment-related challenges and problems need to be faced at global level, leading to the globalization of the engineering profession which requires not only the capacity to communicate in a common technical language, but also the assurance of an adequate and common level of technical competences, knowledge and understanding. In this framework, the Europe-based EUR ACE (European Accreditation of Engineering Programmes) system, currently operated by ENAEE - European Network for Accreditation of Engineering Education can represent the proper framework and accreditation system in order to provide a set of measures to assess the quality of engineering degree programmes in Europe and abroad. The application of the accreditation model EUR-ACE, and of the National Italian Degree Courses Accreditation System, promoted by the Italian National Agency for the Evaluation of Universities and Research Institutes (ANVUR), to the Environmental Engineering Degree Courses at the University of Firenze is presented. In

  10. MicroASC instrument onboard Juno spacecraft utilizing inertially controlled imaging

    DEFF Research Database (Denmark)

    Pedersen, David Arge Klevang; Jørgensen, Andreas Härstedt; Benn, Mathias

    2016-01-01

    This contribution describes the post-processing of the raw image data acquired by the microASC instrument during the Earth-fly-by of the Juno spacecraft. The images show a unique view of the Earth and Moon system as seen from afar. The procedure utilizes attitude measurements and inter......-calibration of the Camera Head Units of the microASC system to trigger the image capturing. The triggering is synchronized with the inertial attitude and rotational phase of the sensor acquiring the images. This is essentially works as inertially controlled imaging facilitating image acquisition from unexplored...

  11. The effect of magnetic stimulation on the osteogenic and chondrogenic differentiation of human stem cells derived from the adipose tissue (hASCs)

    Energy Technology Data Exchange (ETDEWEB)

    Lima, João; Gonçalves, Ana I.; Rodrigues, Márcia T.; Reis, Rui L. [3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães (Portugal); ICVS/3Bs–PT Government Associate Laboratory, Braga/Guimarães (Portugal); Gomes, Manuela E., E-mail: megomes@dep.uminho.pt [3Bs Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães (Portugal); ICVS/3Bs–PT Government Associate Laboratory, Braga/Guimarães (Portugal)

    2015-11-01

    The use of magnetic nanoparticles (MNPs) towards the musculoskeletal tissues has been the focus of many studies, regarding MNPs ability to promote and direct cellular stimulation and orient tissue responses. This is thought to be mainly achieved by mechano-responsive pathways, which can induce changes in cell behavior, including the processes of proliferation and differentiation, in response to external mechanical stimuli. Thus, the application of MNP-based strategies in tissue engineering may hold potential to propose novel solutions for cell therapy on bone and cartilage strategies to accomplish tissue regeneration. The present work aims at studying the influence of MNPs on the osteogenic and chondrogenic differentiation of human adipose derived stem cells (hASCs). MNPs were incorporated in hASCs and cultured in medium supplemented for osteogenic and chondrogenic differentiation. Cultures were maintained up to 28 days with/without an external magnetic stimulus provided by a magnetic bioreactor, to determine if the MNPs alone could affect the osteogenic or chondrogenic phenotype of the hASCs. Results indicate that the incorporation of MNPs does not negatively affect the viability nor the proliferation of hASCs. Furthermore, Alizarin Red staining evidences an enhancement in extracellular (ECM) mineralization under the influence of an external magnetic field. Although not as evident as for osteogenic differentiation, Toluidine blue and Safranin-O stainings also suggest the presence of a cartilage-like ECM with glycosaminoglycans and proteoglycans under the magnetic stimulus provided. Thus, MNPs incorporated in hASCs under the influence of an external magnetic field have the potential to induce differentiation towards the osteogenic and chondrogenic lineages. - Highlights: • Cellular viability was not negatively influenced by the nanoparticles. • Chondrogenic medium influences more the synthesis of cartilage-like ECM than MNPs. • Synergetic effect among

  12. The effect of magnetic stimulation on the osteogenic and chondrogenic differentiation of human stem cells derived from the adipose tissue (hASCs)

    International Nuclear Information System (INIS)

    Lima, João; Gonçalves, Ana I.; Rodrigues, Márcia T.; Reis, Rui L.; Gomes, Manuela E.

    2015-01-01

    The use of magnetic nanoparticles (MNPs) towards the musculoskeletal tissues has been the focus of many studies, regarding MNPs ability to promote and direct cellular stimulation and orient tissue responses. This is thought to be mainly achieved by mechano-responsive pathways, which can induce changes in cell behavior, including the processes of proliferation and differentiation, in response to external mechanical stimuli. Thus, the application of MNP-based strategies in tissue engineering may hold potential to propose novel solutions for cell therapy on bone and cartilage strategies to accomplish tissue regeneration. The present work aims at studying the influence of MNPs on the osteogenic and chondrogenic differentiation of human adipose derived stem cells (hASCs). MNPs were incorporated in hASCs and cultured in medium supplemented for osteogenic and chondrogenic differentiation. Cultures were maintained up to 28 days with/without an external magnetic stimulus provided by a magnetic bioreactor, to determine if the MNPs alone could affect the osteogenic or chondrogenic phenotype of the hASCs. Results indicate that the incorporation of MNPs does not negatively affect the viability nor the proliferation of hASCs. Furthermore, Alizarin Red staining evidences an enhancement in extracellular (ECM) mineralization under the influence of an external magnetic field. Although not as evident as for osteogenic differentiation, Toluidine blue and Safranin-O stainings also suggest the presence of a cartilage-like ECM with glycosaminoglycans and proteoglycans under the magnetic stimulus provided. Thus, MNPs incorporated in hASCs under the influence of an external magnetic field have the potential to induce differentiation towards the osteogenic and chondrogenic lineages. - Highlights: • Cellular viability was not negatively influenced by the nanoparticles. • Chondrogenic medium influences more the synthesis of cartilage-like ECM than MNPs. • Synergetic effect among

  13. Environmental engineering education - summary report of the 1st European Seminar

    DEFF Research Database (Denmark)

    Alha, K; Holliger, C.; Larsen, Bo Skjold

    2000-01-01

    This paper summarizes the discussions of the 1st European Seminar on Environmental Engineering Education (E3), which was held at EAWAG, Zurich, Switzerland in August 1999. Although the emerging discipline of environmental engineering, which was once viewed as being a sub-set of civil or chemical...... engineering, has established a status in its own right, a definition of environmental engineering is still not agreed among European engineering educators. This report discusses the variation between European countries and the way in which higher education institutions in these countries address...... the educational needs of environmental engineers. A review of the acceptance of this new discipline by employers and the status of environmental engineering as a profession throughout Europe is presented. The question of how to achieve greater compatibility and comparability of the systems of environmental...

  14. The suitability of human adipose-derived stem cells for the engineering of ligament tissue.

    Science.gov (United States)

    Eagan, Michael J; Zuk, Patricia A; Zhao, Ke-Wei; Bluth, Benjamin E; Brinkmann, Elyse J; Wu, Benjamin M; McAllister, David R

    2012-10-01

    Rupture of the anterior cruciate ligament (ACL) is the one of the most common sports-related injuries. With its poor healing capacity, surgical reconstruction using either autografts or allografts is currently required to restore function. However, serious complications are associated with graft reconstructions and the number of such reconstructions has steadily risen over the years, necessitating the search for an alternative approach to ACL repair. Such an approach may likely be tissue engineering. Recent engineering approaches using ligament-derived fibroblasts have been promising, but the slow growth rate of such fibroblasts in vitro may limit their practical application. More promising results are being achieved using bone marrow mesenchymal stem cells (MSCs). The adipose-derived stem cell (ASC) is often proposed as an alternative choice to the MSC and, as such, may be a suitable stem cell for ligament engineering. However, the use of ASCs in ligament engineering still remains relatively unexplored. Therefore, in this study, the potential use of human ASCs in ligament tissue engineering was initially explored by examining their ability to express several ligament markers under growth factor treatment. ASC populations treated for up to 4 weeks with TGFβ1 or IGF1 did not show any significant and consistent upregulation in the expression of collagen types 1 and 3, tenascin C and scleraxis. While treatment with EGF or bFGF resulted in increased tenascin C expression, increased expression of collagens 1 and 3 were never observed. Therefore, simple in vitro treatment of human ASC populations with growth factors may not stimulate their ligament differentiative potential. Copyright © 2011 John Wiley & Sons, Ltd.

  15. 78 FR 50052 - Chief of Engineers Environmental Advisory Board; Meeting

    Science.gov (United States)

    2013-08-16

    ... DEPARTMENT OF DEFENSE Department of the Army; Corps of Engineers Chief of Engineers Environmental... Environmental Advisory Board (EAB). Date: September 11, 2013. Time: 9:00 a.m. through 12:00 p.m. Location: Room... Agenda: The Board will advise the Chief of Engineers on environmental policy, identification and...

  16. [Effects of chronic fluoxetine treatment on manifestation of sexual motivation and social behavior in mice of ASC line].

    Science.gov (United States)

    Tikhonova, M A; Otroshchenko, E A; Kulikov, A V

    2010-02-01

    Sexual dysfunctions are the typical symptoms accompanying depressive disorders. However antidepressants which improve general state of the patients have no effect on sexual disorders. Mice of ASC (Antidepressant Sensitive Catalepsy) line with high hereditary predisposition to catalepsy were proposed as a model of genetically associated depressive-like condition. The work was aimed at comparison of behavioral indices of sexual motivation and social interest of ASC mice with those of mice of parental inbred AKR and CBA strains, and at the study of the effects of chronic fluoxetine treatment in doses of 10 and 20 mg/kg on these parameters in ASC mice. ASC males demonstrated reduced sexual motivation which was not corrected by fluoxetine. ASC mice did not differ in the expression of social interest and aggression towards juvenile intruder from mice of parental strains. Fluoxetine failed to alter social behavior of ASC mice in social interaction test but its higher dose decreased percentage of aggressors. ASC mouse line seems to be a perspective model to study genetic mechanisms of sexual dysfunctions associated with depressive conditions.

  17. Environmental Engineering Talent Demand and Undergraduate Education in China

    Science.gov (United States)

    Zhang, Huan-zhen; Li, Jian-bo; Luo, Xiang-nan; Zhao, Bin-yan; Luo, Ren-ming; Wang, Qiao-ling

    2004-01-01

    In Chinese higher environmental education, undergraduate education of environmental engineering starts earliest and develops fastest. The undergraduate has been playing an important role in controlling pollution for more than twenty years. The setting and distribution of the environmental engineering major was analyzed, the conditions of the…

  18. Acute stress among adolescents and female rape victims measured by ASC-Kids: a pilot study.

    Science.gov (United States)

    Nilsson, Doris; Nordenstam, Carin; Green, Sara; Wetterhall, Annika; Lundin, Tom; Svedin, Carl Göran

    2015-01-01

    Rape is considered a stressful trauma and often with durable consequences. How the aftermath of rape is for young adolescents' girls considering acute stress is an overlooked field and remains to be studied. In this study, we wanted to investigate acute stress among adolescent victims of rape and the psychometric properties of the Acute Stress Checklist for Children (ASC-Kids). A clinical sample (n = 79) of raped girls, 13-17 years old who had turned to a special rape victim unit for treatment, answered the ASC-Kids. ASC-Kids was also given to a group of minor stressed, non-raped adolescents in the same age range (n = 154) together with the University of California at Los Angeles Post-traumatic Stress Disorder Reaction Index (UCLA PTSD RI), and the Sense of Coherence Scale 13 (SOC-13). The scores from the groups were compared and showed significant differences in mean values on all the diagnostic criteria of acute stress disorder. In the clinical group, 36.7% obtained full ASD criteria. ASC-Kids could discriminate well between groups. Cronbach's alpha was found to be excellent, and the correlation between the UCLA PTSD RI and ASC-Kids found to be good; both ASC-Kids and UCLA PTSD RI had a good and moderate negative correlation with SOC-13. Adolescent female rape victims were shown to have a very high level of acute stress, and the ASC-Kids was found to have sound psychometrics and can be a valuable screening instrument to support clinicians in their assessments of an indication of adolescents after potentially stressful events such as rape.

  19. Sensors for everyday life environmental and food engineering

    CERN Document Server

    Postolache, Octavian; Jayasundera, Krishanthi; Swain, Akshya

    2017-01-01

    This book offers an up-to-date overview of the concepts, modeling, technical and technological details and practical applications of different types of sensors, and discusses the trends of next generation of sensors and systems for environmental and food engineering. This book is aimed at researchers, graduate students, academics and industry professionals working in the field of environmental and food engineering, environmental monitoring, precision agriculture and food quality control.

  20. Fundamentals of environmental engineering. 2. rev. ed.

    International Nuclear Information System (INIS)

    Bank, M.

    1994-01-01

    'Fundamentals of Environmental Engineering' contains the technical and legal bases for the force environmental areas water supply and waste water disposal, clean air, waste avoidance and waste disposal, as well as noise protection in compact form. Particular scope was allowed for the description of the linkages between the individual environmental areas - for instance, waste combustion and clean air, waste deposition at landfills and treatment of leachate, residual products from successful water and air pollution control measures. For all those who have to familiarize themselves with the complex subject of 'environmental engineering' while in training or during continuing education this book offers a broad approach to the essential general, technical and legal bases. (orig.) [de

  1. Efficient myogenic differentiation of human adipose-derived stem cells by the transduction of engineered MyoD protein

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Min Sun [Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of); Biosystems and Bioengineering Program, University of Science and Technology (UST), Daejeon 305-350 (Korea, Republic of); Mun, Ji-Young [Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of); Kwon, Ohsuk [Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of); Biosystems and Bioengineering Program, University of Science and Technology (UST), Daejeon 305-350 (Korea, Republic of); Kwon, Ki-Sun [Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of); Oh, Doo-Byoung, E-mail: dboh@kribb.re.kr [Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of); Biosystems and Bioengineering Program, University of Science and Technology (UST), Daejeon 305-350 (Korea, Republic of)

    2013-07-19

    Highlights: •MyoD was engineered to contain protein transduction domain and endosome-disruptive INF7 peptide. •The engineered MyoD-IT showed efficient nuclear targeting through an endosomal escape by INF7 peptide. •By applying MyoD-IT, human adipose-derived stem cells (hASCs) were differentiated into myogenic cells. •hASCs differentiated by applying MyoD-IT fused to myotubes through co-culturing with mouse myoblasts. •Myogenic differentiation using MyoD-IT is a safe method without the concern of altering the genome. -- Abstract: Human adipose-derived stem cells (hASCs) have great potential as cell sources for the treatment of muscle disorders. To provide a safe method for the myogenic differentiation of hASCs, we engineered the MyoD protein, a key transcription factor for myogenesis. The engineered MyoD (MyoD-IT) was designed to contain the TAT protein transduction domain for cell penetration and the membrane-disrupting INF7 peptide, which is an improved version of the HA2 peptide derived from influenza. MyoD-IT showed greatly improved nuclear targeting ability through an efficient endosomal escape induced by the pH-sensitive membrane disruption of the INF7 peptide. By applying MyoD-IT to a culture, hASCs were efficiently differentiated into long spindle-shaped myogenic cells expressing myosin heavy chains. Moreover, these cells differentiated by an application of MyoD-IT fused to myotubes with high efficiency through co-culturing with mouse C2C12 myoblasts. Because internalized proteins can be degraded in cells without altering the genome, the myogenic differentiation of hASCs using MyoD-IT would be a safe and clinically applicable method.

  2. Efficient myogenic differentiation of human adipose-derived stem cells by the transduction of engineered MyoD protein

    International Nuclear Information System (INIS)

    Sung, Min Sun; Mun, Ji-Young; Kwon, Ohsuk; Kwon, Ki-Sun; Oh, Doo-Byoung

    2013-01-01

    Highlights: •MyoD was engineered to contain protein transduction domain and endosome-disruptive INF7 peptide. •The engineered MyoD-IT showed efficient nuclear targeting through an endosomal escape by INF7 peptide. •By applying MyoD-IT, human adipose-derived stem cells (hASCs) were differentiated into myogenic cells. •hASCs differentiated by applying MyoD-IT fused to myotubes through co-culturing with mouse myoblasts. •Myogenic differentiation using MyoD-IT is a safe method without the concern of altering the genome. -- Abstract: Human adipose-derived stem cells (hASCs) have great potential as cell sources for the treatment of muscle disorders. To provide a safe method for the myogenic differentiation of hASCs, we engineered the MyoD protein, a key transcription factor for myogenesis. The engineered MyoD (MyoD-IT) was designed to contain the TAT protein transduction domain for cell penetration and the membrane-disrupting INF7 peptide, which is an improved version of the HA2 peptide derived from influenza. MyoD-IT showed greatly improved nuclear targeting ability through an efficient endosomal escape induced by the pH-sensitive membrane disruption of the INF7 peptide. By applying MyoD-IT to a culture, hASCs were efficiently differentiated into long spindle-shaped myogenic cells expressing myosin heavy chains. Moreover, these cells differentiated by an application of MyoD-IT fused to myotubes with high efficiency through co-culturing with mouse C2C12 myoblasts. Because internalized proteins can be degraded in cells without altering the genome, the myogenic differentiation of hASCs using MyoD-IT would be a safe and clinically applicable method

  3. Research report 1987-1989: Environmental Quality Laboratory and Environmental Engineering Science, W. M. Keck Laboratories

    OpenAIRE

    Brooks, Norman H.

    1990-01-01

    This research biennial report for 1987-89 covers the activities of both the Environmental Engineering Science program and the Environmental Quality Laboratory for the period October 1987-November 1989. Environmental Engineering Science is the degree-granting academic program housed in the Keck Laboratories, with associated research projects. The Environmental Quality Laboratory is a research center focusing on large scale problems of environmental quality and natural resources. All the facult...

  4. Mechanical Stimulation of Adipose-Derived Stem Cells for Functional Tissue Engineering of the Musculoskeletal System via Cyclic Hydrostatic Pressure, Simulated Microgravity, and Cyclic Tensile Strain.

    Science.gov (United States)

    Nordberg, Rachel C; Bodle, Josie C; Loboa, Elizabeth G

    2018-01-01

    It is critical that human adipose stem cell (hASC) tissue-engineering therapies possess appropriate mechanical properties in order to restore function of the load bearing tissues of the musculoskeletal system. In an effort to elucidate the hASC response to mechanical stimulation and develop mechanically robust tissue engineered constructs, recent research has utilized a variety of mechanical loading paradigms including cyclic tensile strain, cyclic hydrostatic pressure, and mechanical unloading in simulated microgravity. This chapter describes methods for applying these mechanical stimuli to hASC to direct differentiation for functional tissue engineering of the musculoskeletal system.

  5. Developments in environmental and engineering law in 1990

    International Nuclear Information System (INIS)

    Brandner, T.

    1991-01-01

    The detailed and clear compilation for the period 1.1.1990-31.1.1991 covers the following topics: Environmental and engineering law in the German unification process; superordinate developments in the EG and in Germany, in particular: Draft Federal Environmental Code, Civil Environmental Liability Act, EIA, German Federal Environmental Foundation; technological safety; climate protection - international agreements, EC law, developments in Germany; air and noise pollution control law; atomic and radiation protection law - point of departure, legislation, individual questions: Federal supervision, nuclear disposal and recycling. Moreover: Environmental concerns in regional planning; the law of nature conservation, water protection, waste management, hazardous materials, genetic engineering and soil protection. (HSCH) [de

  6. Environmental impact assessment of a turboprop engine with the aid of exergy

    International Nuclear Information System (INIS)

    Atılgan, Ramazan; Turan, Önder; Altuntaş, Önder; Aydın, Hakan; Synylo, Kateryna

    2013-01-01

    To develop approaches that effectively reduce engine environmental effect of aircrafts, it is necessary to understand the mechanisms that have enabled improvements in thermodynamic efficiency of aircraft engines. In the present work, a turboprop engine used in regional aircrafts that produces 1948 shp and 640 N.m torque is examined using exergo-environmental method. The results show compressor, combustion chamber, gas generator turbine, power turbine and exhaust nozzle create 9%, 69%, 13%, 7%, 2% of total environmental impact of the engine, respectively. According to rates, the compressor and gas turbine can be considered first to improve in case of component related environmental impact. Furthermore, total component related environmental impact for the turboprop engine is found to be 2.26 mPts/s for the constructional phase and 2.34 mPts/s for the operation/maintenance phases. Accordingly, it is suggested that, in order to estimate environmental impact metric of aircrafts, the exergo-environmental analysis can be employed for aircraft propulsion systems. - Highlights: • Evaluating the exergo-environmental aspects of the turboprop engine. • According to exergo-environmental results, the biggest candidate for improving is the combustion chamber. • Specific environmental impact dominates at engine exhaust outlet of the turboprop engine. • Greatest total component related environmental impact is found at the gas generator turbine of the turboprop engine

  7. Environmental engineering: Saving a threatened resource--In search of solutions

    International Nuclear Information System (INIS)

    Linaweaver, F.P.

    1992-01-01

    This proceedings, Environmental Engineering: Saving a Threatened Resource--In search of solutions, contains papers presented at the 1992 National Conference on Environmental Engineering, a component of Water Forum '92, Baltimore, Maryland, August 2-5, 1992. Some of the topics addressed include air quality; environmental assessment; sludge management and disposal; solid waste, toxic and hazardous materials; water supply and treatment; and water/wastewater infrastructure. In addition, key areas explored are toxicity reduction; urban nonpoint source pollution; incineration; landfills; leachate control; and VOC emissions from wastewater treatment plants. This publication provides the environmental engineer with state-of-the-art information on practical environmental engineering and results from recent advancements in scientific knowledge in this field. Individual papers are processed separately for inclusion in the appropriate data bases

  8. 7 CFR 1780.55 - Preliminary engineering reports and Environmental Reports.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Preliminary engineering reports and Environmental..., Designing, Bidding, Contracting, Constructing and Inspections § 1780.55 Preliminary engineering reports and Environmental Reports. Preliminary engineering reports (PERs) must conform to customary professional standards...

  9. Engineering noble metal nanomaterials for environmental applications

    Science.gov (United States)

    Li, Jingguo; Zhao, Tingting; Chen, Tiankai; Liu, Yanbiao; Ong, Choon Nam; Xie, Jianping

    2015-04-01

    Besides being valuable assets in our daily lives, noble metals (namely, gold, silver, and platinum) also feature many intriguing physical and chemical properties when their sizes are reduced to the nano- or even subnano-scale; such assets may significantly increase the values of the noble metals as functional materials for tackling important societal issues related to human health and the environment. Among which, designing/engineering of noble metal nanomaterials (NMNs) to address challenging issues in the environment has attracted recent interest in the community. In general, the use of NMNs for environmental applications is highly dependent on the physical and chemical properties of NMNs. Such properties can be readily controlled by tailoring the attributes of NMNs, including their size, shape, composition, and surface. In this feature article, we discuss recent progress in the rational design and engineering of NMNs with particular focus on their applications in the field of environmental sensing and catalysis. The development of functional NMNs for environmental applications is highly interdisciplinary, which requires concerted efforts from the communities of materials science, chemistry, engineering, and environmental science.

  10. Engineering noble metal nanomaterials for environmental applications.

    Science.gov (United States)

    Li, Jingguo; Zhao, Tingting; Chen, Tiankai; Liu, Yanbiao; Ong, Choon Nam; Xie, Jianping

    2015-05-07

    Besides being valuable assets in our daily lives, noble metals (namely, gold, silver, and platinum) also feature many intriguing physical and chemical properties when their sizes are reduced to the nano- or even subnano-scale; such assets may significantly increase the values of the noble metals as functional materials for tackling important societal issues related to human health and the environment. Among which, designing/engineering of noble metal nanomaterials (NMNs) to address challenging issues in the environment has attracted recent interest in the community. In general, the use of NMNs for environmental applications is highly dependent on the physical and chemical properties of NMNs. Such properties can be readily controlled by tailoring the attributes of NMNs, including their size, shape, composition, and surface. In this feature article, we discuss recent progress in the rational design and engineering of NMNs with particular focus on their applications in the field of environmental sensing and catalysis. The development of functional NMNs for environmental applications is highly interdisciplinary, which requires concerted efforts from the communities of materials science, chemistry, engineering, and environmental science.

  11. Environmental engineering. 2. ed.

    International Nuclear Information System (INIS)

    Foerstner, U.

    1991-01-01

    This introductory textbook has been written in response to the demand for information on environmentally sound techniques and methods. On the basis of the knowledge taught in traditional engineering sciences, and referring to it, the author explains the specific problems encountered in the various environmental sectors, and reviews and discusses the technical solutions available or possible. In this process, there is, of course, opportunity or reason enough to refer to ecologic, economic, ethical or legal aspects, too. The book takes pollutants in a very general sense, their origin (sources), dispersion or transport, and their effects on the environment, as a red thread leading to the relevant technical equipment or engineering methods for problem solution in the various environmental sectors. An extensive and detailed bibliography points to literature for further reading. This second edition under review focusses on environmental problems in the eastern states of the Federal Republic: an account of the situation there refers to 'water' (catchment area of the Elbe river), 'soil' (long-standing pollution due to the mining industry in Thueringen and Sachsen), and 'air' (dispersion of pollutants, radon in uranium mines). The chapter 'Pollutants' now contains references to the handling of noxious chemical in accordance with the Ordinance on transport and handling of dangerous goods, explains the (mis)-development in the chlorine industry, shows the different dispersion processes of organic chemicals, etc. The chapters 'waste' and 'recycling' now part more emphasis on showing the significance of short- or medium-termed measures for prevention or rentilization of waste. (orig./HSCH) With 116 figs [de

  12. Environmental engineering. 3. ed.

    International Nuclear Information System (INIS)

    Foerstner, U.

    1992-01-01

    This introductory textbook has been written in response to the demand for information on environmentally sound techniques and methods. On the basis of the knowledge taught in traditional engineering sciences, and referring to it, the author explains the specific problems encountered in the various environmental sectors, and reviews and discusses the technical solutions available or possible. In this process, there is, of course, opportunity or reason enough to refer to ecologic, economic, ethical or legal aspects, too. The book takes pollutants in a very general sense, their origin (sources), dispersion or transport, and their effects on the environment, as a red thread leading to the relevant technical equipment or engineering methods for problem solution in the various environmental sectors. An extensive and detailed bibliography points to literature for further reading. This third edition under review focusses on environmental problems in the eastern states of the Federal Republic: an account of the situation there refers to 'water' (catchment area of the Elbe river), 'soil' (long-standing pollution due to the mining industry in Thueringen and Sachsen), and 'air' (dispersion of pollutants, radon in uranium mines). The chapter 'Pollutants' now contains references to the handling of noxious chemical in accordance with the Ordinance on transport and handling of dangerous goods, explains the (mis)-development in the chlorine industry, shows the different dispersion processes of organic chemicals, etc. The chapters 'waste' and 'recycling' now part more emphasis on showing the significance of short- or medium-termed measures for prevention or rentilization of waste. (orig.) With 116 figs [de

  13. Function of microRNAs in the Osteogenic Differentiation and Therapeutic Application of Adipose-Derived Stem Cells (ASCs

    Directory of Open Access Journals (Sweden)

    Walter M. Hodges

    2017-12-01

    Full Text Available Traumatic wounds with segmental bone defects represent substantial reconstructive challenges. Autologous bone grafting is considered the gold standard for surgical treatment in many cases, but donor site morbidity and associated post-operative complications remain a concern. Advances in regenerative techniques utilizing mesenchymal stem cell populations from bone and adipose tissue have opened the door to improving bone repair in the limbs, spine, and craniofacial skeleton. The widespread availability, ease of extraction, and lack of immunogenicity have made adipose-derived stem cells (ASCs particularly attractive as a stem cell source for regenerative strategies. Recently it has been shown that small, non-coding miRNAs are involved in the osteogenic differentiation of ASCs. Specifically, microRNAs such as miR-17, miR-23a, and miR-31 are expressed during the osteogenic differentiation of ASCs, and appear to play a role in inhibiting various steps in bone morphogenetic protein-2 (BMP2 mediated osteogenesis. Importantly, a number of microRNAs including miR-17 and miR-31 that act to attenuate the osteogenic differentiation of ASCs are themselves stimulated by transforming growth factor β-1 (TGFβ-1. In addition, transforming growth factor β-1 is also known to suppress the expression of microRNAs involved in myogenic differentiation. These data suggest that preconditioning strategies to reduce TGFβ-1 activity in ASCs may improve the therapeutic potential of ASCs for musculoskeletal application. Moreover, these findings support the isolation of ASCs from subcutaneous fat depots that tend to have low endogenous levels of TGFβ-1 expression.

  14. Transport phenomena in environmental engineering

    Science.gov (United States)

    Sander, Aleksandra; Kardum, Jasna Prlić; Matijašić, Gordana; Žižek, Krunoslav

    2018-01-01

    A term transport phenomena arises as a second paradigm at the end of 1950s with high awareness that there was a strong need to improve the scoping of chemical engineering science. At that point, engineers became highly aware that it is extremely important to take step forward from pure empirical description and the concept of unit operations only to understand the specific process using phenomenological equations that rely on three elementary physical processes: momentum, energy and mass transport. This conceptual evolution of chemical engineering was first presented with a well-known book of R. Byron Bird, Warren E. Stewart and Edwin N. Lightfoot, Transport Phenomena, published in 1960 [1]. What transport phenomena are included in environmental engineering? It is hard to divide those phenomena through different engineering disciplines. The core is the same but the focus changes. Intention of the authors here is to present the transport phenomena that are omnipresent in treatment of various process streams. The focus in this chapter is made on the transport phenomena that permanently occur in mechanical macroprocesses of sedimentation and filtration for separation in solid-liquid particulate systems and on the phenomena of the flow through a fixed and a fluidized bed of particles that are immanent in separation processes in packed columns and in environmental catalysis. The fundamental phenomena for each thermal and equilibrium separation process technology are presented as well. Understanding and mathematical description of underlying transport phenomena result in scoping the separation processes in a way that ChEs should act worldwide.

  15. Environmental education in Saudi general environment system - an engineering perspective

    International Nuclear Information System (INIS)

    Abdulrahman Salih Hariri

    2006-01-01

    The Saudi Cabinet of Ministers approved the Saudi General Environment System (SGES) in 2001. This approval is considered a step forward towards preserving the environment in Saudi Arabia. One of the targets of this system is to make environmental planning as an un-replaceable part of every comprehensive development planning in all industrial, agricultural, and architectural sectors. Achieving such a target requires a specialized labor force. Therefore, College of Engineering should act positively and actively in disseminating environmental awareness among engineers since they play a major rule in development projects. A degree in environmental engineering is a must at present, which is not available yet at any university in Saudi Arabia. Details of a B. Sc degree in environmental engineering offered by two universities in USA, are discussed. The syllabus of a degree in environment engineering adapted for the Saudi environment and culture is outlined

  16. Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

    DEFF Research Database (Denmark)

    Wang, Xiaole; Hald, Helle; Ernst, Heidi Asschenfeldt

    2010-01-01

    The human alanine-serine-cysteine transporter 1 (Asc-1) belongs to the slc7a family of solute carrier transporters. Asc-1 mediates the uptake of D-serine in an exchanger-type fashion, coupling the process to the release of alanine and cysteine. Among the bacterial Asc-1 homologues, one transporter...... of auto-induction was crucial for obtaining high yields and purity of the transporter. The transporter was purified with yields in the range of 0.2-0.4 mg per L culture and eluted in a single peak from a size-exclusion column. The circular dichroism spectrum revealed a folded and apparently all...

  17. Engineering proteins for environmental applications

    NARCIS (Netherlands)

    Janssen, Dick B.; Schanstra, Joost P.

    1994-01-01

    Recently, significant new insight has been obtained into the structure and catalytic mechanism of enzymes that convert environmental pollutants. Recent advances in protein engineering make it possible to use this information for improving the catalytic performance of such enzymes to achieve

  18. Dynamic culture induces a cell type-dependent response impacting on the thickness of engineered connective tissues.

    Science.gov (United States)

    Fortier, Guillaume Marceau; Gauvin, Robert; Proulx, Maryse; Vallée, Maud; Fradette, Julie

    2013-04-01

    Mesenchymal cells are central to connective tissue homeostasis and are widely used for tissue-engineering applications. Dermal fibroblasts and adipose-derived stromal cells (ASCs) allow successful tissue reconstruction by the self-assembly approach of tissue engineering. This method leads to the production of multilayered tissues, devoid of exogenous biomaterials, that can be used as stromal compartments for skin or vesical reconstruction. These tissues are formed by combining cell sheets, generated through cell stimulation with ascorbic acid, which favours the cell-derived production/organization of matrix components. Since media motion can impact on cell behaviour, we investigated the effect of dynamic culture on mesenchymal cells during tissue reconstruction, using the self-assembly method. Tissues produced using ASCs in the presence of a wave-like movement were nearly twice thicker than under standard conditions, while no difference was observed for tissues produced from dermal fibroblasts. The increased matrix deposition was not correlated with an increased proliferation of ASCs, or by higher transcript levels of fibronectin or collagens I and III. A 30% increase of type V collagen mRNA was observed. Interestingly, tissues engineered from dermal fibroblasts featured a four-fold higher level of MMP-1 transcripts under dynamic conditions. Mechanical properties were similar for tissues reconstructed using dynamic or static conditions. Finally, cell sheets produced using ASCs under dynamic conditions could readily be manipulated, resulting in a 2 week reduction of the production time (from 5 to 3 weeks). Our results describe a distinctive property of ASCs' response to media motion, indicating that their culture under dynamic conditions leads to optimized tissue engineering. Copyright © 2011 John Wiley & Sons, Ltd.

  19. Research on the Development and Enlightenment of Urban Environmental Engineering

    Science.gov (United States)

    Tian, Mingjing; Li, Guanglou; Zhang, Lu; Shou, Youping; Li, Yajuan; Ye, Wei; Xu, Jing

    2018-04-01

    In recent years, under the promotion of reform and opening up, China's economic development has greatly accelerated, urbanization is also gradually accelerated. In the process of urbanization, there are many problems. The development of environmental engineering is one of the most important points. While building our living environment; we should also pay attention to the implementation of sustainable development strategies. First of all, This paper describes basic situation of environmental engineering, and finally provided some measures to promote the strengthening of China's environmental engineering

  20. Atypical squamous cells, cannot exclude high grade squamous intraepithelial (ASC-H in HIV-positive women

    Directory of Open Access Journals (Sweden)

    Michelow Pam

    2010-01-01

    Full Text Available Objective: South Africa has very high rates of both HIV infection and cervical pathology. The management of ASC-H is colposcopy and directed biopsy, but with so many women diagnosed with HSIL and a dearth of colposcopy centres in South Africa, women with cytologic diagnosis of ASC-H may not be prioritized for colposcopy. The aim of this study was to determine if HIV-positive women with a cytologic diagnosis of ASC-H should undergo immediate colposcopy or whether colposcopy can be delayed, within the context of an underfunded health care setting with so many competing health needs. Materials and Methods: A computer database search was performed from the archives of an NGO-administered clinic that offers comprehensive HIV care. All women with a cytologic diagnosis of ASC-H on cervical smears from September 2005 until August 2009 were identified. Histologic follow up was sought in all patients. Results: A total of 2111 cervical smears were performed and 41 diagnosed as ASC-H (1.94%. No histologic follow up data was available in 15 cases. Follow up histologic results were as follows: three negative (11.5%, five koilocytosis and/ or CIN1 (19.2%, ten CIN2 (38.5% and eight CIN3 (30.8%. There were no cases of invasive carcinoma on follow up. Conclusion: The current appropriate management of HIV-positive women in low-resource settings with a diagnosis of ASC-H on cervical smear is colposcopy, despite the costs involved. In the future and if cost-effective in developing nations, use of novel markers may help select which HIV-positive women can be managed conservatively and which ones referred for more active treatment. More research in this regard is warranted.

  1. ASC Addresses Unit Commanders' Concerns through LBE and Reset Programs

    National Research Council Canada - National Science Library

    Young, Mark E

    2008-01-01

    .... Army Sustainment Command (ASC), part of the U.S. Army Materiel Command (AMC) team, is available to assist, identify, and resolve equipment and maintenance problems as well as materiel readiness issues for combatant commanders...

  2. Distance Teaching of Environmental Engineering Courses at the Open University.

    Science.gov (United States)

    Porteous, Andrew; Nesaratnam, Suresh T.; Anderson, Judith

    1997-01-01

    Describes two integrated distance learning environmental engineering degree courses offered by the environmental engineering group of the Open University in Great Britain. Discusses admission requirements for courses, advantages offered by distance learning, professional accreditation, site visits, and tutors. (AIM)

  3. The American Satellite Company (ASC) satellite deployed from payload bay

    Science.gov (United States)

    1985-01-01

    The American Satellite Company (ASC) communications satellite is deployed from the payload bay of the Shuttle Discovery. A portion of the cloudy surface of the earth can be seen to the left of the frame.

  4. Idaho National Engineering and Environmental Laboratory Environmental Technologies Proof-of-Concepts. Final report FY-96

    Energy Technology Data Exchange (ETDEWEB)

    Barrie, S.L.; Carpenter, G.S.; Crockett, A.B. [and others

    1997-04-01

    The Idaho National Engineering and Environmental Laboratory Environmental Technologies Proof-of-Concept Project was initiated for the expedited development of new or conceptual technologies in support of groundwater fate, transport, and remediation; buried waste characterization, retrieval, and treatment; waste minimization/pollution prevention; and spent fuel handling and storage. In Fiscal Year 1996, The Idaho National Engineering and Environmental Laboratory proposed 40 development projects and the Department of Energy funded 15. The projects proved the concepts of the various technologies, and all the technologies contribute to successful environmental management.

  5. Idaho National Engineering and Environmental Laboratory Environmental Technologies Proof-of-Concepts. Final report FY-96

    International Nuclear Information System (INIS)

    Barrie, S.L.; Carpenter, G.S.; Crockett, A.B.

    1997-04-01

    The Idaho National Engineering and Environmental Laboratory Environmental Technologies Proof-of-Concept Project was initiated for the expedited development of new or conceptual technologies in support of groundwater fate, transport, and remediation; buried waste characterization, retrieval, and treatment; waste minimization/pollution prevention; and spent fuel handling and storage. In Fiscal Year 1996, The Idaho National Engineering and Environmental Laboratory proposed 40 development projects and the Department of Energy funded 15. The projects proved the concepts of the various technologies, and all the technologies contribute to successful environmental management

  6. Ultrasound in environmental engineering. Papers

    Energy Technology Data Exchange (ETDEWEB)

    Tiehm, A; Neis, U [eds.

    1999-07-01

    This book presents recent research and state-of-the-art information on the scientific basis, modes of use, and engineering developments of ultrasound application in the field of environmental protection. The information is loosely grouped into the following themes: ultrasound and sonochemistry, design of sonoreactors, applications in water, waste water and sludge treatment: aggregation of suspended particles, degradation of hazardous pollutants, disinfection, disintegration of biosolids. Ultrasound is generated and applied at frequencies from 20 kHz to several MHz. Reactor design, applied intensity, duration of sonication, and physico-chemical parameters of the sonicated media influence ultrasound effects. Thus, ultrasound, at a first glance, is a complex and probably confusing matter. This book has been compiled from presentations held at the first workshop 'Ultrasound in Environmental Engineering' on March 22nd and 23rd, 1999, at the Technical University of Hamburg-Harburg in cooperation with the German Association for the Water Environment (ATV) and the DECHEMA e.V. (orig.)

  7. Ultrasound in environmental engineering. Papers

    Energy Technology Data Exchange (ETDEWEB)

    Tiehm, A.; Neis, U. [eds.

    1999-07-01

    This book presents recent research and state-of-the-art information on the scientific basis, modes of use, and engineering developments of ultrasound application in the field of environmental protection. The information is loosely grouped into the following themes: ultrasound and sonochemistry, design of sonoreactors, applications in water, waste water and sludge treatment: aggregation of suspended particles, degradation of hazardous pollutants, disinfection, disintegration of biosolids. Ultrasound is generated and applied at frequencies from 20 kHz to several MHz. Reactor design, applied intensity, duration of sonication, and physico-chemical parameters of the sonicated media influence ultrasound effects. Thus, ultrasound, at a first glance, is a complex and probably confusing matter. This book has been compiled from presentations held at the first workshop 'Ultrasound in Environmental Engineering' on March 22nd and 23rd, 1999, at the Technical University of Hamburg-Harburg in cooperation with the German Association for the Water Environment (ATV) and the DECHEMA e.V. (orig.)

  8. FY17 ASC CSSE L2 Milestone 6018: Power Usage Characteristics of Workloads Running on Trinity.

    Energy Technology Data Exchange (ETDEWEB)

    Pedretti, Kevin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-01

    The overall goal of this work was to utilize the Advanced Power Management (APM) capabilities of the ATS-1 Trinity platform to understand the power usage behavior of ASC workloads running on Trinity and gain insight into the potential for utilizing power management techniques on future ASC platforms.

  9. Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner.

    Directory of Open Access Journals (Sweden)

    Jung-Eun Koo

    Full Text Available Orientia tsutsugamushi, a causative agent of scrub typhus, is an obligate intracellular bacterium, which escapes from the endo/phagosome and replicates in the host cytoplasm. O. tsutsugamushi infection induces production of pro-inflammatory mediators including interleukin-1β (IL-1β, which is secreted mainly from macrophages upon cytosolic stimuli by activating cysteine protease caspase-1 within a complex called the inflammasome, and is a key player in initiating and maintaining the inflammatory response. However, the mechanism for IL-1β maturation upon O. tsutsugamushi infection has not been identified. In this study, we show that IL-1 receptor signaling is required for efficient host protection from O. tsutsugamushi infection. Live Orientia, but not heat- or UV-inactivated Orientia, activates the inflammasome through active bacterial uptake and endo/phagosomal maturation. Furthermore, Orientia-stimulated secretion of IL-1β and activation of caspase-1 are ASC- and caspase-1- dependent since IL-1β production was impaired in Asc- and caspase-1-deficient macrophages but not in Nlrp3-, Nlrc4- and Aim2-deficient macrophages. Therefore, live O. tsutsugamushi triggers ASC inflammasome activation leading to IL-1β production, which is a critical innate immune response for effective host defense.

  10. Evaluation of gold nanotracers to track adipose-derived stem cells in a PEGylated fibrin gel for dermal tissue engineering applications

    Directory of Open Access Journals (Sweden)

    Chung E

    2013-01-01

    Full Text Available Eunna Chung,1 Seung Yun Nam,1,2 Laura M Ricles,1 Stanislav Y Emelianov,1,2 Laura J Suggs11Department of Biomedical Engineering, 2Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX, USAAbstract: Evaluating the regenerative capacity of a tissue-engineered device in a noninvasive and synchronous manner is critical to determining the mechanisms for success in clinical applications. In particular, directly tracking implanted cells in a three-dimensional (3D scaffold is desirable in that it enables the monitoring of cellular activity in a specific and localized manner. The authors' group has previously demonstrated that the PEGylation of fibrin results in a 3D scaffold that supports morphologic and phenotypic changes in mesenchymal stem cells that may be advantageous in wound healing applications. Recently, the authors have evaluated adipose-derived stem cells (ASCs as a mesenchymal cell source to regenerate skin and blood vessels due to their potential for proliferation, differentiation, and production of growth factors. However, tracking and monitoring ASCs in a 3D scaffold, such as a PEGylated fibrin gel, have not yet been fully investigated. In the current paper, nanoscale gold spheres (20 nm as cell tracers for ASCs cultured in a PEGylated fibrin gel were evaluated. An advanced dual-imaging modality combining ultrasound and photoacoustic imaging was utilized to monitor rat ASCs over time. The ASCs took up gold nanotracers and could be detected up to day 16 with high sensitivity using photoacoustic imaging. There were no detrimental effects on ASC morphology, network formation, proliferation, and protein expression/secretion (ie, smooth muscle α-actin, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 associated with gold nanotracers. Therefore, utilization of gold nanotracers can be an effective strategy to monitor the regenerative process of a stem cell

  11. Characterization of the Advanced Stirling Radioisotope Generator Engineering Unit 2

    Science.gov (United States)

    Lewandowski, Edward J.; Oriti, Salvatore M.; Schifer, Niholas A.

    2016-01-01

    Significant progress was made developing the Advanced Stirling Radioisotope Generator (ASRG) 140-W radioisotope power system. While the ASRG flight development project has ended, the hardware that was designed and built under the project is continuing to be tested to support future Stirling-based power system development. NASA Glenn Research Center recently completed the assembly of the ASRG Engineering Unit 2 (EU2). The ASRG EU2 consists of the first pair of Sunpower's Advanced Stirling Convertor E3 (ASC-E3) Stirling convertors mounted in an aluminum housing, and Lockheed Martin's Engineering Development Unit (EDU) 4 controller (a fourth-generation controller). The ASC-E3 convertors and Generator Housing Assembly (GHA) closely match the intended ASRG Qualification Unit flight design. A series of tests were conducted to characterize the EU2, its controller, and the convertors in the flight-like GHA. The GHA contained an argon cover gas for these tests. The tests included measurement of convertor, controller, and generator performance and efficiency; quantification of control authority of the controller; disturbance force measurement with varying piston phase and piston amplitude; and measurement of the effect of spacecraft direct current (DC) bus voltage on EU2 performance. The results of these tests are discussed and summarized, providing a basic understanding of EU2 characteristics and the performance and capability of the EDU 4 controller.

  12. Environmental Testing of the NEXT PM1R Ion Engine

    Science.gov (United States)

    Snyder, John S.; Anderson, John R.; VanNoord, Jonathan L.; Soulas, George C.

    2007-01-01

    The NEXT propulsion system is an advanced ion propulsion system presently under development that is oriented towards robotic exploration of the solar system using solar electric power. The subsystem includes an ion engine, power processing unit, feed system components, and thruster gimbal. The Prototype Model engine PM1 was subjected to qualification-level environmental testing in 2006 to demonstrate compatibility with environments representative of anticipated mission requirements. Although the testing was largely successful, several issues were identified including the fragmentation of potting cement on the discharge and neutralizer cathode heater terminations during vibration which led to abbreviated thermal testing, and generation of particulate contamination from manufacturing processes and engine materials. The engine was reworked to address most of these findings, renamed PM1R, and the environmental test sequence was repeated. Thruster functional testing was performed before and after the vibration and thermal-vacuum tests. Random vibration testing, conducted with the thruster mated to the breadboard gimbal, was executed at 10.0 Grms for 2 min in each of three axes. Thermal-vacuum testing included three thermal cycles from 120 to 215 C with hot engine re-starts. Thruster performance was nominal throughout the test program, with minor variations in a few engine operating parameters likely caused by facility effects. There were no significant changes in engine performance as characterized by engine operating parameters, ion optics performance measurements, and beam current density measurements, indicating no significant changes to the hardware as a result of the environmental testing. The NEXT PM1R engine and the breadboard gimbal were found to be well-designed against environmental requirements based on the results reported herein. The redesigned cathode heater terminations successfully survived the vibration environments. Based on the results of this test

  13. The role of colposcopy and typization of human papillomavirus in further diagnostic proceedings in patients with ASC-US cytological finding of the uterine cervix

    Directory of Open Access Journals (Sweden)

    Živadinović Radomir

    2009-01-01

    Full Text Available Background/Aim. Bethesda system of classification of cytological findings was introduced in 2001 two subcategories in the category of atypical squamous cells (ASC findings: ASC of undetermined significance (ASC-US and ASC which cannot exclude high-grade intraepithelial lesions (ASC-H. The aim of our study was to assess a possible association of these two subcategories with pathologic biopsy finding and to find out the best further diagnostic proceedings. Methods. At the Clinic of Gynecology and Obstetrics, Niš 130 patients with ASC findings were analyzed. Colposcopy was performed in all study participants. Patients with pathological colposcopic findings underwent cervical biopsy. In 10 patients with pathologic histologic and 15 with benign findings human papilloma virus (HPV typization was done using the Hybrid Capture method. Results. Patients with ASC-H finding had significantly more pathologic biopsies compared with patients with ASC-US finding (57.84: 20.72. Conclusion. Colposcopy was exhibited somewhat higher sensitivity compared to HPV typization (94.7 : 90, but lower sensitivity (79.27 : 86.6. The usage of HPV typization in the triage of patients with ASC cytologic smear induces statistically significant reduction of unnecessary percentage of cervical biopsies.

  14. Antidepressant-Like Effects of Central BDNF Administration in Mice of Antidepressant Sensitive Catalepsy (ASC) Strain.

    Science.gov (United States)

    Tikhonova, Maria; Kulikov, Alexander V

    2012-08-31

    Although numerous data evidence the implication of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression, the potential for BDNF to correct genetically defined depressive-like states is poorly studied. This study was aimed to reveal antidepressant-like effects of BDNF (300 ng, 2×, i.c.v.) on behavior and mRNA expression of genes associated with depression-like state in the brain in mice of antidepressant sensitive catalepsy (ASC) strain characterized by high hereditary predisposition to catalepsy and depressive-like features. Behavioral tests were held on the 7th-16th days after the first (4th-13th after the second) BDNF injection. Results showed that BDNF normalized impaired sexual motivation in the ASC males, and this BDNF effect differed, with advantageous effects, from that of widely used antidepressants. The anticataleptic effect of two BDNF injections was enhanced compared with a single administration. A tendency to decrease the immobility duration in tail-suspension test was observed in BDNF-treated ASC mice. The effects on catalepsy and sexual motivation were specific since BDNF did not alter locomotor and exploratory activity or social interest in the ASC mice. Along with behavioral antidepressant-like effects on the ASC mice, BDNF increased hippocampal mRNA levels of Bdnf and Creb1 (cAMP response element-binding protein gene). BDNF also augmented mRNA levels of Arc gene encoding Arc (Activity-regulated cytoskeleton-associated) protein involved in BDNF-induced processes of neuronal and synaptic plasticity in hippocampus and prefrontal cortex. The data suggest that: [1] BDNF is effective in the treatment of some genetically defined behavioral disturbances; [2] BDNF influences sexually-motivated behavior; [3] Arc mRNA levels may serve as a molecular marker of BDNF physiological activity associated with its long-lasting behavioral effects; [4] ASC mouse strain can be used as a suitable model to study mechanisms of BDNF effects on

  15. ASC Trilab L2 Codesign Milestone 2015

    Energy Technology Data Exchange (ETDEWEB)

    Trott, Christian Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hammond, Simon David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dinge, Dennis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Paul T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Vaughan, Courtenay T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cook, Jeanine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Edwards, Harold C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rajan, Mahesh [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoekstra, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    For the FY15 ASC L2 Trilab Codesign milestone Sandia National Laboratories performed two main studies. The first study investigated three topics (performance, cross-platform portability and programmer productivity) when using OpenMP directives and the RAJA and Kokkos programming models available from LLNL and SNL respectively. The focus of this first study was the LULESH mini-application developed and maintained by LLNL. In the coming sections of the report the reader will find performance comparisons (and a demonstration of portability) for a variety of mini-application implementations produced during this study with varying levels of optimization. Of note is that the implementations utilized including optimizations across a number of programming models to help ensure claims that Kokkos can provide native-class application performance are valid. The second study performed during FY15 is a performance assessment of the MiniAero mini-application developed by Sandia. This mini-application was developed by the SIERRA Thermal-Fluid team at Sandia for the purposes of learning the Kokkos programming model and so is available in only a single implementation. For this report we studied its performance and scaling on a number of machines with the intent of providing insight into potential performance issues that may be experienced when similar algorithms are deployed on the forthcoming Trinity ASC ATS platform.

  16. NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling.

    Science.gov (United States)

    Lech, Maciej; Lorenz, Georg; Kulkarni, Onkar P; Grosser, Marian O O; Stigrot, Nora; Darisipudi, Murthy N; Günthner, Roman; Wintergerst, Maximilian W M; Anz, David; Susanti, Heni Eka; Anders, Hans-Joachim

    2015-12-01

    The NLRP3/ASC inflammasome drives host defence and autoinflammatory disorders by activating caspase-1 to trigger the secretion of mature interleukin (IL)-1β/IL-18, but its potential role in autoimmunity is speculative. We generated and phenotyped Nlrp3-deficient, Asc-deficient, Il-1r-deficient and Il-18-deficient C57BL/6-lpr/lpr mice, the latter being a mild model of spontaneous lupus-like autoimmunity. While lack of IL-1R or IL-18 did not affect the C57BL/6-lpr/lpr phenotype, lack of NLRP3 or ASC triggered massive lymphoproliferation, lung T cell infiltrates and severe proliferative lupus nephritis within 6 months, which were all absent in age-matched C57BL/6-lpr/lpr controls. Lack of NLRP3 or ASC increased dendritic cell and macrophage activation, the expression of numerous proinflammatory mediators, lymphocyte necrosis and the expansion of most T cell and B cell subsets. In contrast, plasma cells and autoantibody production were hardly affected. This unexpected immunosuppressive effect of NLRP3 and ASC may relate to their known role in SMAD2/3 phosphorylation during tumour growth factor (TGF)-β receptor signalling, for example, Nlrp3-deficiency and Asc-deficiency significantly suppressed the expression of numerous TGF-β target genes in C57BL/6-lpr/lpr mice and partially recapitulated the known autoimmune phenotype of Tgf-β1-deficient mice. These data identify a novel non-canonical immunoregulatory function of NLRP3 and ASC in autoimmunity. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  17. ASC Tri-lab Co-design Level 2 Milestone Report 2015

    Energy Technology Data Exchange (ETDEWEB)

    Hornung, Rich [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Jones, Holger [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Keasler, Jeff [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Neely, Rob [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pearce, Olga [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hammond, Si [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Trott, Christian [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Paul [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Vaughan, Courtenay [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cook, Jeanine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoekstra, Rob [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bergen, Ben [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Payne, Josh [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Womeldorff, Geoff [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-23

    In 2015, the three Department of Energy (DOE) National Laboratories that make up the Advanced Sci- enti c Computing (ASC) Program (Sandia, Lawrence Livermore, and Los Alamos) collaboratively explored performance portability programming environments in the context of several ASC co-design proxy applica- tions as part of a tri-lab L2 milestone executed by the co-design teams at each laboratory. The programming environments that were studied included Kokkos (developed at Sandia), RAJA (LLNL), and Legion (Stan- ford University). The proxy apps studied included: miniAero, LULESH, CoMD, Kripke, and SNAP. These programming models and proxy-apps are described herein. Each lab focused on a particular combination of abstractions and proxy apps, with the goal of assessing performance portability using those. Performance portability was determined by: a) the ability to run a single application source code on multiple advanced architectures, b) comparing runtime performance between \

  18. EEE (environmental engineering economics) attributes for oil and gas industry

    International Nuclear Information System (INIS)

    Isreb, M.

    2006-01-01

    This paper outlined the basic attributes of environmental engineering economics (EEE) with reference to the oil and gas industry in Australia. The paper was designed as a reference guide for policy-makers, educators, and environmental engineers. Methods of calculating the Pareto Optimum status were discussed, and environmental values and principles were identified. Air quality indicators were outlined. The paper considered multidisciplinary approaches to EEE and sustainable development, as well as the application of statistics and qualitative methods in addressing contemporary issues. The ethical aspects of environmental policies were discussed. Issues related to environmental toxicity and public health were also examined. Various taxation approaches and financial incentives were reviewed. Environmental laws related to the oil and gas industry were outlined. Environmental assessment procedures were presented. It was concluded that environmental regulations within the industry will help to ensure appropriate pollution reductions. 7 refs

  19. Environmental Testing of the NEXT PM1 Ion Engine

    Science.gov (United States)

    Synder, John S.; Anderson, John R.; VanNoord, Jonathan L.; Soulas, George C.

    2008-01-01

    The NEXT propulsion system is an advanced ion propulsion system presently under development that is oriented towards robotic exploration of the solar system using solar electric power. The Prototype Model engine PM1 was subjected to qualification-level environmental testing to demonstrate compatibility with environments representative of anticipated mission requirements. Random vibration testing, conducted with the thruster mated to the breadboard gimbal, was executed at 10.0 Grms for 2 minutes in each of three axes. Thermal-vacuum testing included a deep cold soak of the engine to temperatures of -168 C and thermal cycling from -120 to 203 C. Although the testing was largely successful, several issues were identified including the fragmentation of potting cement on the discharge and neutralizer cathode heater terminations during vibration which led to abbreviated thermal testing, and generation of particulate contamination from manufacturing processes and engine materials. Thruster performance was nominal throughout the test program, with minor variations in some engine operating parameters likely caused by facility effects. In general, the NEXT PM1 engine and the breadboard gimbal were found to be well-designed against environmental requirements based on the results reported herein. After resolution of the findings from this test program the hardware environmental qualification program can proceed with confidence.

  20. Aeroacoustics research in Europe : the CEAS-ASC report on 2007 highlights

    NARCIS (Netherlands)

    Brouwer, H.H.; Rienstra, S.W.

    2008-01-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on a European scale and European aeronautics activities internationally. In this context, "aeroacoustics"

  1. Enhancing environmental engineering education in Europe

    Science.gov (United States)

    Caporali, Enrica; Tuneski, Atanasko

    2013-04-01

    In the frame of knowledge triangle: education-innovation-research, the environmental engineering higher education is here discussed with reference to the TEMPUS-Trans European Mobility Programme for University Studies promoted by the European Commission. Among the focused aspects of TEMPUS are curricula harmonization and lifelong learning programme development in higher education. Two are the curricula, since the first TEMPUS project, coordinated in the period 2005-2008 by University of Firenze in cooperation with colleagues of the Ss Cyril and Methodius University, Skopje. The second three years TEMPUS Joint Project denominated DEREL-Development of Environment and Resources Engineering Learning, is active since October 2010. To the consortium activities participate 4 EU Universities (from Italy, Greece, Germany and Austria), 7 Partner Countries (PC) Universities (from FYR of Macedonia, Serbia and Albania), and 1 PC Ministry, 4 PC National Agencies, 1 PC non governmental organization and 1 PC enterprise. The same 4 EU Universities and the same Macedonian Institutions participated at the first TEMPUS JEP entitled DEREC-Development of Environmental and Resources Engineering Curriculum. Both the first and second cycle curriculum, developed through the co-operation, exchange of know-how and expertise between partners, are based on the European Credit Transfer System and are in accordance with the Bologna Process. Within DEREC a new three-years first cycle curriculum in Environmental and Resources Engineering was opened at the University Ss Cyril and Methodius, Skopje, and the necessary conditions for offering a Joint Degree Title, on the basis of an agreement between the Ss. Cyril and Methodius University and the University of Firenze, were fulfilled. The running DEREL project, as a continuation of DEREC, is aimed to introduce a new, up-to-date, postgraduate second cycle curriculum in Environment and Resources Engineering at the Ss Cyril and Methodius University in

  2. Predicting on-site environmental impacts of municipal engineering works

    OpenAIRE

    Gangolells Solanellas, Marta; Casals Casanova, Miquel; Forcada Matheu, Núria; Macarulla Martí, Marcel

    2014-01-01

    The research findings fill a gap in the body of knowledge by presenting an effective way to evaluate the significance of on-site environmental impacts of municipal engineering works prior to the construction stage. First, 42 on-site environmental impacts of municipal engineering works were identified by means of a process-oriented approach. Then, 46 indicators and their corresponding significance limits were determined on the basis of a statistical analysis of 25 new-build and remodelling mun...

  3. Surface engineering and environmental issues

    International Nuclear Information System (INIS)

    Aguero, A.

    2007-01-01

    Surface engineering addresses the modification of the microstructure and/or composition of the surface of components by mechanical, physical or chemical methods that may imply adding a material in order to change the surface properties of said components. One of its most important consequences is the significant increase of the useful life of a variety of components in a large number of industrial applications. Moreover, it contributes to energy savings by increasing efficiencies as it allows higher combustion temperatures, by allowing the use of lighter components and by significant friction reduction. In this paper, surface engineering is introduced, as well as its different modalities, examples of industrial applications and positive and negative environmental impacts. (Author) 29 refs

  4. Characterization of a novel variant of amino acid transport system asc in erythrocytes from Przewalski's horse (Equus przewalskii).

    Science.gov (United States)

    Fincham, D A; Ellory, J C; Young, J D

    1992-08-01

    In thoroughbred horses, red blood cell amino acid transport activity is Na(+)-independent and controlled by three codominant genetic alleles (h, l, s), coding for high-affinity system asc1 (L-alanine apparent Km for influx at 37 degrees C congruent to 0.35 mM), low-affinity system asc2 (L-alanine Km congruent to 14 mM), and transport deficiency, respectively. The present study investigated amino acid transport mechanisms in red cells from four wild species: Przewalski's horse (Equus przewalskii), Hartmann's zebra (Zebra hartmannae), Grevy's zebra (Zebra grevyi), and onager (Equus hemonius). Red blood cell samples from different Przewalski's horses exhibited uniformly high rates of L-alanine uptake, mediated by a high-affinity asc1-type transport system. Mean apparent Km and Vmax values (+/- SE) for L-alanine influx at 37 degrees C in red cells from 10 individual animals were 0.373 +/- 0.068 mM and 2.27 +/- 0.11 mmol (L cells.h), respectively. As in thoroughbreds, the Przewalski's horse transporter interacted with dibasic as well as neutral amino acids. However, the Przewalski asc1 isoform transported L-lysine with a substantially (6.4-fold) higher apparent affinity than its thoroughbred counterpart (Km for influx 1.4 mM at 37 degrees C) and was also less prone to trans-stimulation effects. The novel high apparent affinity of the Przewalski's horse transporter for L-lysine provides additional key evidence of functional and possible structural similarities between asc and the classical Na(+)-dependent system ASC and between these systems and the Na(+)-independent dibasic amino acid transport system y+. Unlike Przewalski's horse, zebra red cells were polymorphic with respect to L-alanine transport activity, showing high-affinity or low-affinity saturable mechanisms of L-alanine uptake. Onager red cells transported this amino acid with intermediate affinity (apparent Km for influx 3.0 mM at 37 degrees C). Radiation inactivation analysis was used to estimate the target

  5. Factors Affecting Innovation Within Aeronautical Systems Center (ASC) Organizations - An inductive Study

    National Research Council Canada - National Science Library

    Feil, Eric

    2003-01-01

    .... This thesis analyzed data collected during the 2002 Chief of Staff of the Air Force Organizational Climate Survey to identify factors that affect innovation within Aeronautical Systems Center (ASC) organizations...

  6. Fuzzy control in environmental engineering

    CERN Document Server

    Chmielowski, Wojciech Z

    2016-01-01

    This book is intended for engineers, technicians and people who plan to use fuzzy control in more or less developed and advanced control systems for manufacturing processes, or directly for executive equipment. Assuming that the reader possesses elementary knowledge regarding fuzzy sets and fuzzy control, by way of a reminder, the first parts of the book contain a reminder of the theoretical foundations as well as a description of the tools to be found in the Matlab/Simulink environment in the form of a toolbox. The major part of the book presents applications for fuzzy controllers in control systems for various manufacturing and engineering processes. It presents seven processes and problems which have been programmed using fuzzy controllers. The issues discussed concern the field of Environmental Engineering. Examples are the control of a flood wave passing through a hypothetical, and then the real Dobczyce reservoir in the Raba River, which is located in the upper Vistula River basin in Southern Poland, th...

  7. Collaborative-Large scale Engineering Assessment Networks for Environmental Research: The Overview

    Science.gov (United States)

    Moo-Young, H.

    2004-05-01

    A networked infrastructure for engineering solutions and policy alternatives is necessary to assess, manage, and protect complex, anthropogenic ally stressed environmental resources effectively. Reductionist and discrete disciplinary methodologies are no longer adequate to evaluate and model complex environmental systems and anthropogenic stresses. While the reductonist approach provides important information regarding individual mechanisms, it cannot provide complete information about how multiple processes are related. Therefore, it is not possible to make accurate predictions about system responses to engineering interventions and the effectiveness of policy options. For example, experts cannot agree on best management strategies for contaminated sediments in riverine and estuarine systems. This is due, in part to the fact that existing models do not accurately capture integrated system dynamics. In addition, infrastructure is not available for investigators to exchange and archive data, to collaborate on new investigative methods, and to synthesize these results to develop engineering solutions and policy alternatives. Our vision for the future is to create a network comprising field facilities and a collaboration of engineers, scientists, policy makers, and community groups. This will allow integration across disciplines, across different temporal and spatial scales, surface and subsurface geographies, and air sheds and watersheds. Benefits include fast response to changes in system health, real-time decision making, and continuous data collection that can be used to anticipate future problems, and to develop sound engineering solutions and management decisions. CLEANER encompasses four general aspects: 1) A Network of environmental field facilities instrumented for the acquisition and analysis of environmental data; 2) A Virtual Repository of Data and information technology for engineering modeling, analysis and visualization of data, i.e. an environmental

  8. Profiling Autism Symptomatology: An Exploration of the Q-ASC Parental Report Scale in Capturing Sex Differences in Autism

    Science.gov (United States)

    Ormond, Sarah; Brownlow, Charlotte; Garnett, Michelle Sarah; Rynkiewicz, Agnieszka; Attwood, Tony

    2018-01-01

    The Questionnaire for Autism Spectrum Conditions (Q-ASC) was developed by Attwood et al. (2011) to identify gender-sensitive profiles of autism symptomatology; prioritise and adjust the direction of clinical interventions; and support positive psychosocial outcomes and prognosis into adulthood. The current research piloted the Q-ASC with parents…

  9. Aeroacoustics research in Europe : the CEAS-ASC report on 1997 highlights

    NARCIS (Netherlands)

    Rienstra, S.W.

    1998-01-01

    This paper is a report on the highlights of aeroacoustics research and development in Europe in 1997, compiled from information provided in the CEAS Aeroacoustics Specialists Committee (ASC). The Confederation of European Aerospace Societies (CEAS) comprises the national Aerospace Societies of

  10. Environmental concentrations of engineered nanomaterials: Review of modeling and analytical studies

    International Nuclear Information System (INIS)

    Gottschalk, Fadri; Sun, TianYin; Nowack, Bernd

    2013-01-01

    Scientific consensus predicts that the worldwide use of engineered nanomaterials (ENM) leads to their release into the environment. We reviewed the available literature concerning environmental concentrations of six ENMs (TiO 2 , ZnO, Ag, fullerenes, CNT and CeO 2 ) in surface waters, wastewater treatment plant effluents, biosolids, sediments, soils and air. Presently, a dozen modeling studies provide environmental concentrations for ENM and a handful of analytical works can be used as basis for a preliminary validation. There are still major knowledge gaps (e.g. on ENM production, application and release) that affect the modeled values, but over all an agreement on the order of magnitude of the environmental concentrations can be reached. True validation of the modeled values is difficult because trace analytical methods that are specific for ENM detection and quantification are not available. The modeled and measured results are not always comparable due to the different forms and sizes of particles that these two approaches target. -- Highlights: •Modeled environmental concentrations of engineered nanomaterials are reviewed. •Measured environmental concentrations of engineered nanomaterials are reviewed. •Possible validation of modeled data by measurements is critically evaluated. •Different approaches in modeling and measurement methods complicate validation. -- Modeled and measured environmental concentrations of engineered nanomaterials are reviewed and critically discussed

  11. Human adipose stem cell and ASC-derived cardiac progenitor cellular therapy improves outcomes in a murine model of myocardial infarction

    Directory of Open Access Journals (Sweden)

    Davy PMC

    2015-10-01

    Full Text Available Philip MC Davy,1 Kevin D Lye,2,3 Juanita Mathews,1 Jesse B Owens,1 Alice Y Chow,1 Livingston Wong,2 Stefan Moisyadi,1 Richard C Allsopp1 1Institute for Biogenesis Research, 2John A. Burns School of Medicine, University of Hawaii at Mānoa, 3Tissue Genesis, Inc., Honolulu, HI, USA Background: Adipose tissue is an abundant and potent source of adult stem cells for transplant therapy. In this study, we present our findings on the potential application of adipose-derived stem cells (ASCs as well as induced cardiac-like progenitors (iCPs derived from ASCs for the treatment of myocardial infarction. Methods and results: Human bone marrow (BM-derived stem cells, ASCs, and iCPs generated from ASCs using three defined cardiac lineage transcription factors were assessed in an immune-compromised mouse myocardial infarction model. Analysis of iCP prior to transplant confirmed changes in gene and protein expression consistent with a cardiac phenotype. Endpoint analysis was performed 1 month posttransplant. Significantly increased endpoint fractional shortening, as well as reduction in the infarct area at risk, was observed in recipients of iCPs as compared to the other recipient cohorts. Both recipients of iCPs and ASCs presented higher myocardial capillary densities than either recipients of BM-derived stem cells or the control cohort. Furthermore, mice receiving iCPs had a significantly higher cardiac retention of transplanted cells than all other groups. Conclusion: Overall, iCPs generated from ASCs outperform BM-derived stem cells and ASCs in facilitating recovery from induced myocardial infarction in mice. Keywords: adipose stem cells, myocardial infarction, cellular reprogramming, cellular therapy, piggyBac, induced cardiac-like progenitors

  12. State of radiotracer application at the Division of Environmental Engineering, CDTN, NUCLEBRAS

    International Nuclear Information System (INIS)

    Aun, P.E.; Castro, J.O.N.M. de; Moreira, R.M.; Bandeira, J.V.

    1984-01-01

    The history and working phylosophy of the NUCLEBRAS division of environmental engineering are reported. Some aspects of tracer applications and of the tasks performed by the division of environmental engineering are described. (M.A.C.) [pt

  13. Development of the environmental management integrated baseline at the Idaho National Engineering Laboratory using systems engineering

    International Nuclear Information System (INIS)

    Murphy, J.A.; Caliva, R.M.; Wixson, J.R.

    1997-01-01

    The Idaho National Engineering Laboratory (INEL) is one of many Department of Energy (DOE) national laboratories that has been performing environmental cleanup and stabilization, which was accelerated upon the end of the cold war. In fact, the INEL currently receives two-thirds of its scope to perform these functions. However, the cleanup is a highly interactive system that creates an opportunity for systems engineering methodology to be employed. At the INEL, a group called EM (Environmental Management) Integration has been given this charter along with a small core of systems engineers. This paper discusses the progress to date of converting the INEL legacy system into one that uses the systems engineering discipline as the method to ensure that external requirements are met

  14. Materials, processes, and environmental engineering network

    Science.gov (United States)

    White, Margo M.

    1993-01-01

    The Materials, Processes, and Environmental Engineering Network (MPEEN) was developed as a central holding facility for materials testing information generated by the Materials and Processes Laboratory. It contains information from other NASA centers and outside agencies, and also includes the NASA Environmental Information System (NEIS) and Failure Analysis Information System (FAIS) data. Environmental replacement materials information is a newly developed focus of MPEEN. This database is the NASA Environmental Information System, NEIS, which is accessible through MPEEN. Environmental concerns are addressed regarding materials identified by the NASA Operational Environment Team, NOET, to be hazardous to the environment. An environmental replacement technology database is contained within NEIS. Environmental concerns about materials are identified by NOET, and control or replacement strategies are formed. This database also contains the usage and performance characteristics of these hazardous materials. In addition to addressing environmental concerns, MPEEN contains one of the largest materials databases in the world. Over 600 users access this network on a daily basis. There is information available on failure analysis, metals and nonmetals testing, materials properties, standard and commercial parts, foreign alloy cross-reference, Long Duration Exposure Facility (LDEF) data, and Materials and Processes Selection List data.

  15. Adapting Infrastructure and Civil Engineering Practice to a Changing Climate: Developing a Manual of Practice

    Science.gov (United States)

    Walker, D.; Ayyub, B. M.

    2017-12-01

    According to U.S. Census, new construction spending in the U.S. for 2014 was $993 Billion (roughly 6 percent of U.S. GDP). Informing the development of standards of engineering practice related to design and maintenance thus represents a significant opportunity to promote climate adaptation and mitigation, as well as community resilience. The climate science community informs us that extremes of climate and weather are changing from historical values and that the changes are driven substantially by emissions of greenhouse gases caused by human activities. Civil infrastructure systems traditionally have been designed, constructed, operated and maintained for appropriate probabilities of functionality, durability and safety while exposed to climate and weather extremes during their full service lives. Because of uncertainties in future greenhouse gas emissions and in the models for future climate and weather extremes, neither the climate science community nor the engineering community presently can define the statistics of future climate and weather extremes. The American Society for Civil Engineering's (ASCE) Committee on Adapting to a Changing Climate is actively involved in efforts internal and external to ASCE to promote understanding of the challenges climate change represents in engineering practice and to promote a re-examination of those practices that may need to change in light of changing climate. In addition to producing an ASCE e-book, as well as number of ASCE webinars, the Committee is currently developing a Manual of Practice intended to provide guidance for the development or enhancement of standards for infrastructure analysis and design in a world in which risk profiles are changing (non-stationarity) and climate change is a reality, but cannot be projected with a high degree of certainty. This presentation will explore both the need for such guidance as well as some of the challenges and opportunities facing its implementation.

  16. 18 CFR Appendix 1 to Part 301 - ASC Utility Filing Template

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false ASC Utility Filing Template 1 Appendix 1 to Part 301 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS FOR FEDERAL POWER MARKETING ADMINISTRATIONS AVERAGE SYSTEM COST...

  17. View of the firing of a single engine OMS

    Science.gov (United States)

    1985-01-01

    View of a single engine orbital maneuvering system (OMS) firing on the Discovery. The payload bay is open and the protective canisters for the AUSSAT communications satellite (open) and the ASC-1 are visible. A cloudy Earth's horizon can be seen above the orbiter.

  18. Enhancing Engineering Students’ Learning in an Environmental Microbiology Course

    Directory of Open Access Journals (Sweden)

    Zhi Zhou

    2012-08-01

    Full Text Available While environmental engineering students have gained some knowledge of biogeochemical cycles and sewage treatment, most of them haven’t learned microbiology previously and usually have difficulty in learning environmental microbiology because microbiology deals with invisible living microorganisms instead of visible built environment. Many teaching techniques can be used to enhance students’ learning in microbiology courses, such as lectures, animations, videos, small-group discussions, and active learning techniques. All of these techniques have been applied in the engineering class, but the results indicate that these techniques are often inadequate for students. Learning difficulties have to be identified to enhance students’ learning.

  19. Evolution of Project-Based Learning in Small Groups in Environmental Engineering Courses

    Science.gov (United States)

    Requies, Jesús M.; Agirre, Ion; Barrio, V. Laura; Graells, Moisès

    2018-01-01

    This work presents the assessment of the development and evolution of an active methodology (Project-Based Learning--PBL) implemented on the course "Unit Operations in Environmental Engineering", within the bachelor's degree in Environmental Engineering, with the purpose of decreasing the dropout rate in this course. After the initial…

  20. A Comparison of ASCE and FAO56 Reference Evapotranspiration at Different Subdaily Timescales: a Numerical Study

    Directory of Open Access Journals (Sweden)

    Farzin Parchami-Araghi

    2017-01-01

    Full Text Available Introduction: Subdaily estimates of reference evapotranspiration (ETo are needed in many applications such as dynamic agro-hydrological modeling. The ASCE and FAO56 Penman–Monteith models (ASCE-PM and FAO56-PM, respectively has received favorable acceptance and application over much of the world, including the United States, for establishing a reference evapotranspiration (ETo index as a function of weather parameters. In the past several years various studies have evaluated ASCE-PM and FAO56-PM models for calculating the commonest hourly or 15-min ETo either by comparing them with lysimetric measurements or by comparison with one another (2, 3, 5, 9, 10, 11, 16, 17, 19. In this study, sub-daily ET o estimates made by the ASCE-PM and FAO56-PM models at different timescales (1-360 min were compared through conduction of a computational experiment, using a daily to sub-daily disaggregation framework developed by Parchami-Araghi et al. (14. Materials and Methods: Daily and sub-daily weather data at different timescales (1-360 min were generated via a daily-to-sub-daily weather data disaggregation framework developed by Parchami-Araghi et al. (14, using long-term (59 years daily weather data obtained from Abadan synoptic weather station. Daily/sub-daily net long wave radiation (Rnl was estimated through 6 different approaches, including using two different criteria for identifying the daytime/nighttime periods : 1 the standard criteria implemented in both ASCE-PM and FAO56-PM models and 2 criterion of actual time of sunset and sunrise in combination with 1 estimation of clear-sky radiation (Rso based on the standard approach implemented in both ASCE-PM and FAO56-PM models (1st and 2nd Rnl estimation approaches, respectively, 2 integral of the Rso estimates derived via a physically based solar radiation model developed by Yang et al. (25, YNG model, for one-second time-steps (3rd and 4th Rnl estimation approaches, respectively, and 3 integral of

  1. Environmental Protection Versus Foundry Engineering Practice

    Directory of Open Access Journals (Sweden)

    Maj M.

    2017-06-01

    Full Text Available • Theory and practice of environmental protection in the case of foundries in Europe and Asia • Experience resulting from the cooperation with the foundries in a few European countries, China and India • Phenomena and factors affecting the pollution of the natural environment and the implementation of measures aiming at the environmental protection. Every specialist dealing with foundry processes and their impact on environmental pollution must have encountered in their professional careers numerous situations in which the theory of environmental protection confronts the stark reality. The discrepancy between theory and practice can particularly be noticed in foundry engineering in developing countries where the contrasts between different countries and casting plants are extremely striking. The comparison of working conditions in European and Asian foundries provides a vast scope for further observations and analyses. Environmental protection seems not only a concern of manufacturers of castings, but also of their customers whose opinion exerts a significant influence on both the acceptability of working conditions and on the approach to environmental pollution adopted in metal casting industry. The article presents a number of examples of various outlooks on environmental issues in foundries manufacturing a wide range of cast steel and cast iron castings, where different technologies and production processes are applied.

  2. Applied statistics for civil and environmental engineers

    CERN Document Server

    Kottegoda, N T

    2009-01-01

    Civil and environmental engineers need an understanding of mathematical statistics and probability theory to deal with the variability that affects engineers'' structures, soil pressures, river flows and the like. Students, too, need to get to grips with these rather difficult concepts.This book, written by engineers for engineers, tackles the subject in a clear, up-to-date manner using a process-orientated approach. It introduces the subjects of mathematical statistics and probability theory, and then addresses model estimation and testing, regression and multivariate methods, analysis of extreme events, simulation techniques, risk and reliability, and economic decision making.325 examples and case studies from European and American practice are included and each chapter features realistic problems to be solved.For the second edition new sections have been added on Monte Carlo Markov chain modeling with details of practical Gibbs sampling, sensitivity analysis and aleatory and epistemic uncertainties, and co...

  3. Androgen receptor (AR) degradation enhancer ASC-J9® in an FDA-approved formulated solution suppresses castration resistant prostate cancer cell growth.

    Science.gov (United States)

    Cheng, Max A; Chou, Fu-Ju; Wang, Keliang; Yang, Rachel; Ding, Jie; Zhang, Qiaoxia; Li, Gonghui; Yeh, Shuyuan; Xu, Defeng; Chang, Chawnshang

    2018-03-28

    ASC-J9 ® is a recently-developed androgen receptor (AR)-degradation enhancer that effectively suppresses castration resistant prostate cancer (PCa) cell proliferation and invasion. The optimal half maximum inhibitory concentrations (IC 50 ) of ASC-J9 ® at various PCa cell confluences (20%, 50%, and 100%) were assessed via both short-term MTT growth assays and long-term clonogenic proliferation assays. Our results indicate that the IC 50 values for ASC-J9 ® increased with increasing cell confluency. The IC 50 values were significantly decreased in PCa AR-positive cells compared to PCa AR-negative cells or in normal prostate cells. This suggests that ASC-J9 ® may function mainly via targeting the AR-positive PCa cells with limited unwanted side-effects to suppress the surrounding normal prostate cells. Mechanism dissection indicated that ASC-J9 ® might function via altering the apoptosis signals to suppress the PCa AR-negative PC-3 cells. Preclinical studies using multiple in vitro PCa cell lines and an in vivo mouse model with xenografted castration-resistant PCa CWR22Rv1 cells demonstrated that ASC-J9 ® has similar AR degradation effects when dissolved in FDA-approved solvents, including DMSO, PEG-400:Tween-80 (95:5), DMA:Labrasol:Tween-80 (10:45:45), and DMA:Labrasol:Tween-20 (10:45:45). Together, results from preclinical studies suggest a potential new therapy with AR-degradation enhancer ASC-J9 ® may potentially be ready to be used in human clinical trials in order to better suppress PCa at later castration resistant stages. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Meet EPA Environmental Engineer Terra Haxton, Ph.D.

    Science.gov (United States)

    EPA Environmental Engineer Terra Haxton, Ph.D., uses computer simulation models to protect drinking water. She investigates approaches to help water utilities be better prepared to respond to contamination incidents in their distribution systems.

  5. Near-Surface Engineered Environmental Barrier Integrity

    International Nuclear Information System (INIS)

    Piet, S.J.; Breckenridge, R.P.

    2002-01-01

    The INEEL Environmental Systems Research and Analysis (ESRA) program has launched a new R and D project on Near-Surface Engineered Environmental Barrier Integrity to increase knowledge and capabilities for using engineering and ecological components to improve the integrity of near-surface barriers used to confine contaminants from the public and the environment. The knowledge gained and the capabilities built will help verify the adequacy of past remedial decisions and enable improved solutions for future cleanup decisions. The research is planned to (a) improve the knowledge of degradation mechanisms (weathering, biological, geological, chemical, radiological, and catastrophic) in times shorter than service life, (b) improve modeling of barrier degradation dynamics, (c) develop sensor systems to identify degradation prior to failure, and (d) provide a better basis for developing and testing of new barrier systems to increase reliability and reduce the risk of failure. Our project combine s selected exploratory studies (benchtop and field scale), coupled effects accelerated aging testing and the meso-scale, testing of new monitoring concepts, and modeling of dynamic systems. The performance of evapo-transpiration, capillary, and grout-based barriers will be examined

  6. Engineering Education: Environmental and Chemical Engineering or Technology Curricula--A European Perspective

    Science.gov (United States)

    Glavic, Peter; Lukman, Rebeka; Lozano, Rodrigo

    2009-01-01

    Over recent years, universities have been incorporating sustainable development (SD) into their systems, including their curricula. This article analyses the incorporation of SD into the curricula of chemical and environmental engineering or technology bachelor degrees at universities in the European Union (EU) and European Free Trade Association…

  7. A study of HPV typing for the management of HPV-positive ASC-US cervical cytologic results.

    Science.gov (United States)

    Schiffman, Mark; Vaughan, Laurence M; Raine-Bennett, Tina R; Castle, Philip E; Katki, Hormuzd A; Gage, Julia C; Fetterman, Barbara; Befano, Brian; Wentzensen, Nicolas

    2015-09-01

    In US cervical screening, immediate colposcopy is recommended for women with HPV-positive ASC-US (equivocal) cytology. We evaluated whether partial typing by Onclarity™ (BD) might identify HPV-positive women with low enough CIN3+ risk to permit 1-year follow-up instead. The NCI-Kaiser Permanente Northern California Persistence and Progression cohort includes a subset of 13,890 women aged 21+ with HC2 (Qiagen)-positive ASC-US at enrollment; current median follow-up is 3.0years. Using stratified random sampling, we typed 2079 archived enrollment specimens including 329 women subsequently diagnosed with CIN3+, 563 with CIN2, and 1187 with ASC-US was 5.2%; this establishes the "benchmark" risk for colposcopic referral. Hierarchically, 3-year cumulative risks for each typing channel were 16.0% for HPV16, 7.4% for HPV18, 7.0% for HPV31, 7.1% for grouped HPV33/58, 4.3% for HPV52, 3.9% for HPV45, 2.7% for HPV51, 1.6% for HPV39/68/35, and 1.3% for HPV59/56/66. ASC-US linked to HPV16, HPV18, HPV31, or HPV33/58 warrants immediate colposcopy. Optimal management of women with HPV52 or HPV45 is uncertain. Risk of women with only HPV51, HPV39/68/35, or HPV59/56/66 might be low enough to recommend 1-year retesting permitting viral clearance. This strategy would defer colposcopy for 40% of women with HPV-positive ASC-US, half of whom would be cotest-negative at 1-year return. Approximately 10% of those with CIN3 diagnosable at enrollment would be delayed 1year instead. Cost-effectiveness analyses are needed. Published by Elsevier Inc.

  8. 1996 LMITCO environmental monitoring program report for the Idaho National Engineering and Environmental Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    This report describes the calendar year 1996 environmental surveillance and compliance monitoring activities of the Lockheed Martin Idaho Technologies Company Environmental Monitoring Program performed at the Idaho National Engineering and Environmental Laboratory (INEEL). Results of sampling performed by the Radiological Environmental Surveillance, Site Environmental Surveillance, Drinking Water, Effluent Monitoring, Storm Water Monitoring, Groundwater Monitoring, and Special Request Monitoring Programs are included in this report. The primary purposes of the surveillance and monitoring activities are to evaluate environmental conditions, to provide and interpret data, to verify compliance with applicable regulations or standards, and to ensure protection of human health and the environment. This report compares 1996 data with program-specific regulatory guidelines and past data to evaluate trends.

  9. 1996 LMITCO environmental monitoring program report for the Idaho National Engineering and Environmental Laboratory

    International Nuclear Information System (INIS)

    1997-09-01

    This report describes the calendar year 1996 environmental surveillance and compliance monitoring activities of the Lockheed Martin Idaho Technologies Company Environmental Monitoring Program performed at the Idaho National Engineering and Environmental Laboratory (INEEL). Results of sampling performed by the Radiological Environmental Surveillance, Site Environmental Surveillance, Drinking Water, Effluent Monitoring, Storm Water Monitoring, Groundwater Monitoring, and Special Request Monitoring Programs are included in this report. The primary purposes of the surveillance and monitoring activities are to evaluate environmental conditions, to provide and interpret data, to verify compliance with applicable regulations or standards, and to ensure protection of human health and the environment. This report compares 1996 data with program-specific regulatory guidelines and past data to evaluate trends

  10. Low-frequency, low-magnitude vibrations (LFLM enhances chondrogenic differentiation potential of human adipose derived mesenchymal stromal stem cells (hASCs

    Directory of Open Access Journals (Sweden)

    Krzysztof Marycz

    2016-02-01

    Full Text Available The aim of this study was to evaluate if low-frequency, low-magnitude vibrations (LFLM could enhance chondrogenic differentiation potential of human adipose derived mesenchymal stem cells (hASCs with simultaneous inhibition of their adipogenic properties for biomedical purposes. We developed a prototype device that induces low-magnitude (0.3 g low-frequency vibrations with the following frequencies: 25, 35 and 45 Hz. Afterwards, we used human adipose derived mesenchymal stem cell (hASCS, to investigate their cellular response to the mechanical signals. We have also evaluated hASCs morphological and proliferative activity changes in response to each frequency. Induction of chondrogenesis in hASCs, under the influence of a 35 Hz signal leads to most effective and stable cartilaginous tissue formation through highest secretion of Bone Morphogenetic Protein 2 (BMP-2, and Collagen type II, with low concentration of Collagen type I. These results correlated well with appropriate gene expression level. Simultaneously, we observed significant up-regulation of α3, α4, β1 and β3 integrins in chondroblast progenitor cells treated with 35 Hz vibrations, as well as Sox-9. Interestingly, we noticed that application of 35 Hz frequencies significantly inhibited adipogenesis of hASCs. The obtained results suggest that application of LFLM vibrations together with stem cell therapy might be a promising tool in cartilage regeneration.

  11. Idaho National Engineering and Environmental Laboratory Wildland Fire Management Environmental Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Irving, John S

    2003-04-01

    DOE prepared an environmental assessment (EA)for wildland fire management activities on the Idaho National Engineering and Environmental Laboratory (INEEL) (DOE/EA-1372). The EA was developed to evaluate wildland fire management options for pre-fire, fire suppression, and post fire activities. Those activities have an important role in minimizing the conversion of the native sagebrush steppe ecosystem found on the INEEL to non-native weeds. Four alternative management approaches were analyzed: Alternative 1 - maximum fire protection; Alternative 2 - balanced fire protection; Alternative 2 - balanced fire protection; Alternative 3 - protect infrastructure and personnel; and Alternative 4 - no action/traditional fire protection.

  12. Interferência do ácido ascórbico na dosagem glicêmica - doi: 10.5102/ucs.v6i2.722

    OpenAIRE

    Aline Cardoso Barbosa; Tania Cristina Andrade

    2009-01-01

    Sabe-se que exames laboratoriais estão sujeitos a fatores interferentes. A literatura científica cita interferência do ácido ascórbico em dosagens que envolvam oxirredução, como a glicêmica. Devido a isto, buscou-se avaliar o efeito do ácido ascórbico sobre a dosagem glicêmica em dois tipos de soro controle submetidos a diferentes concentrações de ácido ascórbico, variando de 2,5 a 100 mg/dL. Utilizou-se um soro controle com valores normais de glicemia e outro com valores patológicos. Observo...

  13. Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out.

    Science.gov (United States)

    Cytryn, Andréa; Russomano, Fábio Bastos; Camargo, Maria José de; Zardo, Lucília Maria Gama; Horta, Nilza Maria Sobral Rebelo; Fonseca, Rachel de Carvalho Silveira de Paula; Tristão, Maria Aparecida; Monteiro, Aparecida Cristina Sampaio

    2009-09-01

    The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS) into ASC-US (undetermined significance) and ASC-H (high-grade intraepithelial lesion cannot be ruled out). The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III) and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF) with ASC-H cytology, and compare them with ASC-US cases. Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis) was taken as the gold standard. The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55%) and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764). Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83); P = 0.2786998). There were no uterine cervical cancer cases. The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions.

  14. Environmental Barrier Coatings for Turbine Engines: A Design and Performance Perspective

    Science.gov (United States)

    Zhu, Dongming; Fox, Dennis S.; Ghosn, Louis; Smialek, James L.; Miller, Robert A.

    2009-01-01

    Ceramic thermal and environmental barrier coatings (TEBC) for SiC-based ceramics will play an increasingly important role in future gas turbine engines because of their ability to effectively protect the engine components and further raise engine temperatures. However, the coating long-term durability remains a major concern with the ever-increasing temperature, strength and stability requirements in engine high heat-flux combustion environments, especially for highly-loaded rotating turbine components. Advanced TEBC systems, including nano-composite based HfO2-aluminosilicate and rare earth silicate coatings are being developed and tested for higher temperature capable SiC/SiC ceramic matrix composite (CMC) turbine blade applications. This paper will emphasize coating composite and multilayer design approach and the resulting performance and durability in simulated engine high heat-flux, high stress and high pressure combustion environments. The advances in the environmental barrier coating development showed promise for future rotating CMC blade applications.

  15. Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H cannot be ruled out

    Directory of Open Access Journals (Sweden)

    Andréa Cytryn

    Full Text Available CONTEXT AND OBJECTIVE: The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS into ASC-US (undetermined significance and ASC-H (high-grade intraepithelial lesion cannot be ruled out. The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF with ASC-H cytology, and compare them with ASC-US cases. DESIGN AND SETTING: Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. METHODS: ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis was taken as the gold standard. RESULTS: The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55% and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764. Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83; P = 0.2786998. There were no uterine cervical cancer cases. CONCLUSION: The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions.

  16. Certain aspects of the environmental impact of nuclear power engineering and thermal power engineering

    Energy Technology Data Exchange (ETDEWEB)

    Malenchenko, A F [AN Belorusskoj SSR, Minsk. Inst. Yadernoj Ehnergetiki

    1979-01-01

    A review is made of the both environmental impact and hazard to man resulting from nuclear power engineering as compared with those of thermal power engineering. At present, in addition to such criteria, as physical-chemical characteristic of energy sources, their efficiency and accessibility for exploitation, new requirements were substantiated in relation to safety of their utilization for environment. So, one of essential problems of nuclear power engineering development consists in assessment and prediction of radioecological consequence. The analysis and operating experience of more than 1000 reactor/years with no accidents and harm for pupulation show, that in respect to impact on environment and man nuclear power engineering is much more safe in comparison with energy sources using tradidional fossile fuel.

  17. HEAT TRANSFER IN EXHAUST SYSTEM OF A COLD START ENGINE AT LOW ENVIRONMENTAL TEMPERATURE

    Directory of Open Access Journals (Sweden)

    Snežana D Petković

    2010-01-01

    Full Text Available During the engine cold start, there is a significantly increased emission of harmful engine exhaust gases, particularly at very low environmental temperatures. Therefore, reducing of emission during that period is of great importance for the reduction of entire engine emission. This study was conducted to test the activating speed of the catalyst at low environmental temperatures. The research was conducted by use of mathematical model and developed computer programme for calculation of non-stationary heat transfer in engine exhaust system. During the research, some of constructional parameters of exhaust system were adopted and optimized at environmental temperature of 22 C. The combination of design parameters giving best results at low environmental temperatures was observed. The results showed that the temperature in the environment did not have any significant influence on pre-catalyst light-off time.

  18. Environmental protection, a task of chemical engineering

    Energy Technology Data Exchange (ETDEWEB)

    Schlachter, H

    1980-12-01

    The environmental burden in air and water in Germany is surveyed. The terms 'eco-unobjectionable technology' and 'disposal technology' are then considered with the aid of examples. These are fundamental chemical engineering approaches for reducing or eliminating environmental burdens due to industrial production processes. 'Eco-unobjectionable processes' are those in which undesired pollutants are not even formed, i.e. when possible emissions are eliminated at source. If this is only partly possible, or impossible, then disposal measures are adopted. This means removal of unavoidable pollutants from waste gases and waste water, and the disposal of other wastes.

  19. Climate engineering field research : The favorable setting of international environmental law

    NARCIS (Netherlands)

    Reynolds, J.L.(Jesse)

    2014-01-01

    As forecasts for climate change and its impacts have become more dire, climate engineering proposals have come under increasing consideration and are presently moving toward field trials. This article examines the relevant international environmental law, distinguishing between climate engineering

  20. Increasing Capacity for Environmental Engineering in Salta, Argentina

    Science.gov (United States)

    Rajal, Verónica B.; Cid, Alicia G.; Cruz, Mercedes C.; Poma, Hugo R.; Cacciabue, Dolores Gutierrez; Romano, Neli; Moraga, Norma B.; Last, Jerold A.

    2012-01-01

    Background The Fogarty International Center (FIC) of the United States National Institutes of Health includes the International Training and Research in Environmental and Occupational Health (ITREOH) Program. The “International Training Program in Environmental Toxicology and Public Health” Center, funded in 2002 is based at the University of California, Davis, and is part of the ITREOH group of Centers. It has major efforts focused at the public universities in Montevideo, Uruguay, and Salta, Argentina. Results Training and research efforts in Salta begun in 2005 in the College of Engineering. A donated used real-time PCR machine was the starting point and the initial FIC support was instrumental to face other problems including physical space, research projects and grants, trainees, training, networking, and distractions/opportunities in order to develop local capacities in Environmental Engineering using modern methodology. After six years of successful work, the Salta center has become a reference Center in the field, and is still growing and consolidating. Conclusions This program has had a significant impact locally and regionally. The model used in Argentina could be easily adapted to other fields or types of projects in Argentina and in other developing countries. PMID:22467330

  1. Increasing capacity for environmental engineering in Salta, Argentina.

    Science.gov (United States)

    Rajal, Verónica B; Cid, Alicia G; Cruz, Mercedes C; Poma, Hugo R; Cacciabue, Dolores Gutierrez; Romano, Neli; Moraga, Norma B; Last, Jerold A

    2013-01-01

    The Fogarty International Center (FIC) of the United States National Institutes of Health includes the International Training and Research in Environmental and Occupational Health (ITREOH) Program. The "International Training Program in Environmental Toxicology and Public Health" Center, funded in 2002 is based at the University of California, Davis, and is part of the ITREOH group of Centers. It has major efforts focused at the public universities in Montevideo, Uruguay, and Salta, Argentina. Training and research efforts in Salta begun in 2005 in the College of Engineering. A donated used real-time PCR machine was the starting point and the initial FIC support was instrumental to face other problems including physical space, research projects and grants, trainees, training, networking, and distractions/opportunities in order to develop local capacities in Environmental Engineering using modern methodology. After 6 years of successful work, the Salta center has become a reference Center in the field, and is still growing and consolidating. This program has had a significant impact locally and regionally. The model used in Argentina could be easily adapted to other fields or types of projects in Argentina and in other developing countries. Copyright © 2012 Wiley Periodicals, Inc.

  2. Environmental aspects of engineering geological mapping in the United States

    Science.gov (United States)

    Radbruch-Hall, Dorothy H.

    1979-01-01

    Many engineering geological maps at different scales have been prepared for various engineering and environmental purposes in regions of diverse geological conditions in the United States. They include maps of individual geological hazards and maps showing the effect of land development on the environment. An approach to assessing the environmental impact of land development that is used increasingly in the United States is the study of a single area by scientists from several disciplines, including geology. A study of this type has been made for the National Petroleum Reserve in northern Alaska. In the San Francisco Bay area, a technique has been worked out for evaluating the cost of different types of construction and land development in terms of the cost of a number of kinds of earth science factors. ?? 1979 International Association of Engineering Geology.

  3. Examining the Relationship between Resistance to Change and Undergraduate Engineering Students' Environmental Knowledge and Attitudes

    Science.gov (United States)

    Dyehouse, Melissa; Weber, Nicole; Fang, Jun; Harris, Constance; David, Ray; Hua, Inez; Strobel, Johannes

    2017-01-01

    Engineering professional associations identified environmental sustainability as a key responsibility of the educated engineer. Data from national surveys of the general public demonstrate low environmental knowledge levels and a high level of resistance when it comes to environmental behavior. The purpose of this study was to examine the…

  4. 1998 Environmental Monitoring Program Report for the Idaho National Engineering and Environmental Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    L. V. Street

    1999-09-01

    This report describes the calendar year 1998 compliance monitoring and environmental surveillance activities of the Lockheed Martin Idaho Technologies Company Environmental Monitoring Program performed at the Idaho National Engineering and Environmental Laboratory. This report includes results of sampling performed by the Drinking Water, Effluent, Storm Water, Groundwater Monitoring, and Environmental Surveillance Programs. This report compares the 1998 results to program-specific regulatory guidelines and past data to evaluate trends. The primary purposes of the monitoring and surveillance activities are to evaluate environmental conditions, to provide and interpret data, to verify compliance with applicable regulations or standards, and to ensure protection of public health and the environment. Surveillance of environmental media did not identify any previously unknown environmental problems or trends, which would indicate a loss of control or unplanned releases from facility operations. The INEEL complied with permits and applicable regulations, with the exception of nitrogen samples in a disposal pond effluent stream and iron and total coliform bacteria in groundwater downgradient from one disposal pond. Data collected by the Environmental Monitoring Program demonstrate that the public health and environment were protected.

  5. ETHICS AND JUSTICE IN ENVIRONMENTAL SCIENCE AND ENGINEERING

    Science.gov (United States)

    Science and engineering are built on trust. C.P. Snow's famous quote, "the only ethical principle which has made science possible is that the truth shall be told all the time" underscores the importance of honesty in science. Environmental scientists must do work that is useful...

  6. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.

    Directory of Open Access Journals (Sweden)

    Toshihiko Suzuki

    2007-08-01

    Full Text Available Shigella infection, the cause of bacillary dysentery, induces caspase-1 activation and cell death in macrophages, but the precise mechanisms of this activation remain poorly understood. We demonstrate here that caspase-1 activation and IL-1beta processing induced by Shigella are mediated through Ipaf, a cytosolic pattern-recognition receptor of the nucleotide-binding oligomerization domain (NOD-like receptor (NLR family, and the adaptor protein apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC. We also show that Ipaf was critical for pyroptosis, a specialized form of caspase-1-dependent cell death induced in macrophages by bacterial infection, whereas ASC was dispensable. Unlike that observed in Salmonella and Legionella, caspase-1 activation induced by Shigella infection was independent of flagellin. Notably, infection of macrophages with Shigella induced autophagy, which was dramatically increased by the absence of caspase-1 or Ipaf, but not ASC. Autophagy induced by Shigella required an intact bacterial type III secretion system but not VirG protein, a bacterial factor required for autophagy in epithelial-infected cells. Treatment of macrophages with 3-methyladenine, an inhibitor of autophagy, enhanced pyroptosis induced by Shigella infection, suggesting that autophagy protects infected macrophages from pyroptosis. Thus, Ipaf plays a critical role in caspase-1 activation induced by Shigella independently of flagellin. Furthermore, the absence of Ipaf or caspase-1, but not ASC, regulates pyroptosis and the induction of autophagy in Shigella-infected macrophages, providing a novel function for NLR proteins in bacterial-host interactions.

  7. Utilization of electromigration in civil and environmental engineering - Processes, transport rates and matrix changes

    DEFF Research Database (Denmark)

    Ottosen, Lisbeth M.; Christensen, Iben Vernegren; Rörig-Dalgaard, Inge

    2008-01-01

    Electromigration (movement of ions in an applied electric field) is utilized for supply or extraction of ions from various porous materials within both civil and environmental engineering. In civil engineering, most research has been conducted on the removal of chlorides from concrete to hinder...... reinforcement corrosion while in environmental engineering remediation of heavy metal polluted soil is the issue most studied. Never the less, experiments have been conducted with utilization for several other materials and purposes within both engineering fields. Even though there are many topics of common...

  8. Estabilidade de ácido ascórbico em sucos de frutas frescos sob diferentes formas de armazenamento

    OpenAIRE

    Cunha, Kelly Damasceno; Silva, Priscila Ribeiro da; Costa, Ana Lígia Faria e Silva da Fonseca; Teodoro, Anderson Junger; Koblitz, Maria Gabriela Bello

    2014-01-01

    O ácido ascórbico é uma vitamina hidrossolúvel de importância nutricional há muito estabelecida, por sua atuação como cofator em diversos processos fisiológicos e como antioxidante. O ser humano depende da ingestão diária desse micronutriente, cujas principais fontes são as frutas e hortaliças. Por ser um nutriente menos estável, o ácido ascórbico sofre perdas no processamento e no armazenamento, influenciadas por diversos fatores, como pH, temperatura, presença de íons, etc. A literatura apr...

  9. The basics of integrating environmental and engineering in early wind farm siting

    Energy Technology Data Exchange (ETDEWEB)

    Alberti, A. [Tetra Tech Inc., Oakville, ON (Canada)

    2010-07-01

    This PowerPoint presentation discussed methods of integrating environmental and engineering studies into the early phases of wind farm siting plans. Most renewable energy development projects begin by an assessment of the transmission capability and renewable resources, followed by engineering and environmental screening procedures. Transmission screening is conducted to identify preliminary interconnection corridors between potential development sites and potential interconnecting transmission lines. Critical issues analysis (CIA) studies identify conditions, siting issues, and potential environmental and engineering tasks related to early scheduling and budget procedures. The components of a CIA include desktop and field studies that are conducted to document issues that warrant special consideration. Team members are comprised of qualified experts who are familiar with the geographic region and are able to collaborate at an early stage in the project. However, many CIA studies do not consider engineering constructability issues or develop strategies for ensuring community support for wind power projects. Conceptual layouts for wind power facilities include information related to turbine locations, access roads, and transmission lines and equipment. Engineering studies are used to evaluate conditions and potential hazards. Issues related to agricultural sites must also be considered. The final locations of turbines must be checked to ensure constructability and energy production potential. tabs., figs.

  10. Tipo de respuesta según el genotipado del virus del papiloma humano según cobas 4800 en las lesiones asc-us HPV positivas

    OpenAIRE

    Kanjou Augé, Nadwa

    2016-01-01

    Objetivos: Evaluar el riesgo de patología subyacente en las pacientes ASC-US HPV positivas de nuestra área de influencia analizadas por el método COBAS 4800. Se estudió el riesgo de CIN2+ en el momento del diagnóstico de las mujeres ASC-US HPV positivas según el genotipo del virus del papiloma: HPV16, HPV18 ( ambos incluyendo coinfecciones) u otros HPV de alto riesgo (HR-HPV). El objetivo es detectar aquellas mujeres con citologías ASC-US HPV positivo con un mayor riesgo de progresión y por l...

  11. Completion Report for Multi-Site Incentive MRT 2779 Implement ASC Tripod Initiative by 30SEP08

    Energy Technology Data Exchange (ETDEWEB)

    East, D; Cerutti, J; Noe, J; Cupps, K; Loncaric, J; Sturtevant, J

    2008-09-22

    This report provides documentation and evidence for the completion of the deployment of the Tripod common operating system (TripodOS, also known as and generally referred to below as TOSS). Background documents for TOSS are provided in Appendices A and B, including the initial TOSS proposal accepted by ASC HQ and Executives in July 2007 and a Governance Model defined by a Tri-Lab working group in September 2007. Appendix C contains a document that clarifies the intent and requirements for the completion criteria associated with MRT 2779. The deployment of TOSS is a Multi-Site Incentive from the ASC FY08-09 Implementation Plan due at the end of Quarter 4 in FY08.

  12. Influence of an Environmental Studies Course on Attitudes of Undergraduates at an Engineering University

    Science.gov (United States)

    Kuo, Shih-Yun; Jackson, Nancy L.

    2014-01-01

    Studies suggest that at engineering universities, where the percentage of males and engineering majors is high, pro-environmental attitudes are likely to be weak and may not change. The 15-item New Ecological Paradigm (NEP) scale was used to measure differences in student attitudes before and after an environmental studies course. Results revealed…

  13. Lean engineering education driving content and competency mastery

    CERN Document Server

    Flumerfelt, Shannon

    2015-01-01

    Recent studies by professional organizations devoted to engineering education, such as Vision 2030 (ASME) and Vision 2025 (ASCE), highlight the need for the restructuring of engineering education. Deficiencies of many engineering graduates include poor systems thinking and systems analysis skills, lack of sensitivity for sustainability issues, poorly developed problem solving skills and lack of training to work in (multi- disciplinary) teams, as well as a lack of leadership, entrepreneurship, innovation, and project management skills. The book's contents include an analysis of current shortfalls in engineering education and education related to professional practice in engineering. Further, the authors describe desirable improvements as well as advocacy for the use of lean tenets and tools to create a new future for engineering education. This book presents, for the first time, an outside-in lean engineering perspective of how this commonly accepted and widely practiced and adapted engineering perspecti...

  14. Bridging Water Resources Policy and Environmental Engineering in the Classroom at Cornell University

    Science.gov (United States)

    Walter, M. T.; Shaw, S. B.; Seifert, S.; Schwarz, T.

    2006-12-01

    Current university undergraduate students in environmental sciences and engineering are the next generation of environmental protection practitioners. Recognizing this, Cornell's Biological and Environmental Engineering department has developed a popular class, Watershed Engineering (BEE 473), specifically designed to bridge the too-common gap between water resources policy and state-of-art science and technology. Weekly homework assignments are to design real-life solutions to actual water resources problems, often with the objective of applying storm water policies to local situations. Where appropriate, usually in conjunction with recent amendments to the Federal Clean Water Act, this course introduces water resource protection tools and concepts developed in the Cornell Soil and Water Lab. Here we present several examples of how we build bridges between university classrooms and the complex world of water resources policy.

  15. Efficient generation of smooth muscle cells from adipose-derived stromal cells by 3D mechanical stimulation can substitute the use of growth factors in vascular tissue engineering.

    Science.gov (United States)

    Parvizi, Mojtaba; Bolhuis-Versteeg, Lydia A M; Poot, André A; Harmsen, Martin C

    2016-07-01

    Occluding artery disease causes a high demand for bioartificial replacement vessels. We investigated the combined use of biodegradable and creep-free poly (1,3-trimethylene carbonate) (PTMC) with smooth muscle cells (SMC) derived by biochemical or mechanical stimulation of adipose tissue-derived stromal cells (ASC) to engineer bioartificial arteries. Biochemical induction of cultured ASC to SMC was done with TGF-β1 for 7d. Phenotype and function were assessed by qRT-PCR, immunodetection and collagen contraction assays. The influence of mechanical stimulation on non-differentiated and pre-differentiated ASC, loaded in porous tubular PTMC scaffolds, was assessed after culturing under pulsatile flow for 14d. Assays included qRT-PCR, production of extracellular matrix and scanning electron microscopy. ASC adhesion and TGF-β1-driven differentiation to contractile SMC on PTMC did not differ from tissue culture polystyrene controls. Mesenchymal and SMC markers were increased compared to controls. Interestingly, pre-differentiated ASC had only marginal higher contractility than controls. Moreover, in 3D PTMC scaffolds, mechanical stimulation yielded well-aligned ASC-derived SMC which deposited ECM. Under the same conditions, pre-differentiated ASC-derived SMC maintained their SMC phenotype. Our results show that mechanical stimulation can replace TGF-β1 pre-stimulation to generate SMC from ASC and that pre-differentiated ASC keep their SMC phenotype with increased expression of SMC markers. Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Construction Site Environmental Impact in Civil Engineering Education

    Science.gov (United States)

    Teixeira, Jose M. Cardoso

    2005-01-01

    The environmental impact of construction activity has gained increasing importance in the last few years and become a key subject for civil engineering education. A survey of Portuguese higher education institutions shows that concern with this topic is mostly directed at the impact of large construction projects and especially focused on their…

  17. Idaho National Engineering and Environmental Laboratory Wildland Fire Management Environmental Assessment - April 2003

    Energy Technology Data Exchange (ETDEWEB)

    Irving, J.S.

    2003-04-30

    DOE prepared an environmental assessment (EA)for wildland fire management activities on the Idaho National Engineering and Environmental Laboratory (INEEL) (DOE/EA-1372). The EA was developed to evaluate wildland fire management options for pre-fire, fire suppression, and post fire activities. Those activities have an important role in minimizing the conversion of the native sagebrush steppe ecosystem found on the INEEL to non-native weeds. Four alternative management approaches were analyzed: Alternative 1 - maximum fire protection; Alternative 2 - balanced fire protection; Alternative 2 - balanced fire protection; Alternative 3 - protect infrastructure and personnel; and Alternative 4 - no action/traditional fire protection.

  18. Exergy, Economic and Environmental Analysis for Simple and Combined Heat and Power IC Engines

    Directory of Open Access Journals (Sweden)

    Mehdi Aliehyaei

    2015-04-01

    Full Text Available This study reports the results of exergy, economic and environmental analyses of simple and combined heat and power internal combustion engines. Values of entropy production, second law efficiency are calculated, and an objective function, including initial, operation, maintenance and fuel costs, as well as the external costs of environmental pollutants, such as CO2, CO and NOx, are presented for the flue gas of the internal combustion engine. The results show that entropy generation in the combined heat and power mode is 30% lower than that in the simple internal combustion engine. Also, by excessively increasing the air ratio, the system entropy generation decreases in both cases of simple and combined heat and power IC engines. The greatest portion of entropy generation is related to the combined heat and power internal combustion engine. The gas heat exchanger generates more entropy than the jacket heat exchanger. Lower values of electricity cost and external costs of air pollution are provided by higher values of molar air to fuel ratio. The environmental aspects depend on location of the system and time of engine operation.

  19. Environmental resource document for the Idaho National Engineering Laboratory. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Irving, J.S.

    1993-07-01

    This document contains information related to the environmental characterization of the Idaho National Engineering Laboratory (INEL). The INEL is a major US Department of Energy facility in southeastern Idaho dedicated to nuclear research, waste management, environmental restoration, and other activities related to the development of technology. Environmental information covered in this document includes land, air, water, and ecological resources; socioeconomic characteristics and land use; and cultural, aesthetic, and scenic resources.

  20. Environmental resource document for the Idaho National Engineering Laboratory. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Irving, J.S.

    1993-07-01

    This document contains information related to the environmental characterization of the Idaho National Engineering Laboratory (INEL). The INEL is a major US Department of Energy facility in southeastern Idaho dedicated to nuclear research, waste management, environmental restoration, and other activities related to the development of technology. Environmental information covered in this document includes land, air, water, and ecological resources; socioeconomic characteristics and land use; and cultural, aesthetic, and scenic resources.

  1. 1997 LMITCO Environmental Monitoring Program Report for the Idaho National Engineering and Environmental Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, B.; Street, L.; Wilhelmsen, R.

    1998-09-01

    This report describes the calendar year 1997 environmental surveillance and compliance monitoring activities of the Lockheed Martin Idaho Technologies Company Environmental Monitoring Program performed at the Idaho National Engineering and Environmental Laboratory. This report includes results of sampling performed by the Radiological Environmental Surveillance, Site Environmental Surveillance, Drinking Water, Effluent Monitoring, Storm Water Monitoring, Groundwater Monitoring, and Special Request Monitoring Programs and compares 1997 data with program-specific regulatory guidelines and past data to evaluate trends. The primary purposes of the surveillance and monitoring activities are to evaluate environmental conditions, to provide and interpret data, to verify compliance with applicable regulations or standard, and to ensure protection of human health and the environment. Surveillance of environmental media did not identify any previously unknown environmental problems or trends indicating a loss of control or unplanned releases from facility operations. With the exception of one nitrogen sample in the disposal pond effluent stream and iron and total coliform bacteria in groundwater downgradient from one disposal pond, compliance with permits and applicable regulations was achieved. Data collected by the Environmental Monitoring Program demonstrate that public health and the environment were protected.

  2. The Barrett Foundation: Undergraduate Research Program for Environmental Engineers and Scientists

    Science.gov (United States)

    Rizzo, D. M.; Paul, M.; Farmer, C.; Larson, P.; Matt, J.; Sentoff, K.; Vazquez-Spickers, I.; Pearce, A. R.

    2007-12-01

    A new program sponsored by The Barrett Foundation in the University of Vermont College of Engineering and Mathematical Sciences (UVM) supports undergraduate students in Environmental Engineering, Earth and Environmental Sciences to pursue independent summer research projects. The Barrett Foundation, a non-profit organization started by a UVM Engineering alum, provided a grant to support undergraduate research. Students must work with at least two different faculty advisors to develop project ideas, then independently prepare a research proposal and submit it to a faculty panel for review. The program was structured as a scholarship to foster a competitive application process. In the last three years, fourteen students have participated in the program. The 2007 Barrett Scholars projects include: - Using bacteria to change the chemistry of subsurface media to encourage calcite precipitation for soil stability and pollutant sequestration - Assessing structural weaknesses in a historic post and beam barn using accelerometers and wireless data collection equipment - Using image processing filters to 1) evaluate leaf wetness, a leading indicator of disease in crops and 2) assess the movement of contaminants through building materials. - Investigating the impact of increased water temperature on cold-water fish species in two Vermont streams. - Studying the impacts of light duty vehicle tailpipe emissions on air quality This program supports applied and interdisciplinary environmental research and introduces students to real- world engineering problems. In addition, faculty from different research focuses are presented the opportunity to establish new collaborations around campus through the interdisciplinary projects. To date, there is a successful publication record from the projects involving the Barrett scholars, including students as authors. One of the objectives of this program was to provide prestigious, competitive awards to outstanding undergraduate engineers

  3. An approach to teaching and research of simulation for environmental engineering design

    NARCIS (Netherlands)

    Bartak, M.; Drkal, F.; Hensen, J.L.M.; Schwarzer, J.; Lain, M.; Sourek, B.

    2003-01-01

    This paper starts out by elaborating why computer modeling and simulation is such an important technique/ tool for modern state-of-the-art environmental engineering. It then continues with how this is currently integrated in engineering analysis and design. The paper continues with describing what

  4. Advanced SiC/SiC Ceramic Composites For Gas-Turbine Engine Components

    Science.gov (United States)

    Yun, H. M.; DiCarlo, J. A.; Easler, T. E.

    2004-01-01

    NASA Glenn Research Center (GRC) is developing a variety of advanced SiC/SiC ceramic composite (ASC) systems that allow these materials to operate for hundreds of hours under stress in air at temperatures approaching 2700 F. These SiC/SiC composite systems are lightweight (approximately 30% metal density) and, in comparison to monolithic ceramics and carbon fiber-reinforced ceramic composites, are able to reliably retain their structural properties for long times under aggressive gas-turbine engine environments. The key for the ASC systems is related first to the NASA development of the Sylramic-iBN Sic fiber, which displays higher thermal stability than any other SiC- based ceramic fibers and possesses an in-situ grown BN surface layer for higher environmental durability. This fiber is simply derived from Sylramic Sic fiber type that is currently produced at ATK COI Ceramics (COIC). Further capability is then derived by using chemical vapor infiltration (CVI) and/or polymer infiltration and pyrolysis (PIP) to form a Sic-based matrix with high creep and rupture resistance as well as high thermal conductivity. The objectives of this study were (1) to optimize the constituents and processing parameters for a Sylramic-iBN fiber reinforced ceramic composite system in which the Sic-based matrix is formed at COIC almost entirely by PIP (full PIP approach), (2) to evaluate the properties of this system in comparison to other 2700 F Sylramic-iBN systems in which the matrix is formed by full CVI and CVI + PIP, and (3) to examine the pros and cons of the full PIP approach for fabricating hot-section engine components. A key goal is the development of a composite system with low porosity, thereby providing high modulus, high matrix cracking strength, high interlaminar strength, and high thermal conductivity, a major property requirement for engine components that will experience high thermal gradients during service. Other key composite property goals are demonstration at

  5. Environmental engineering at the University of Strathclyde in Glasgow

    NARCIS (Netherlands)

    Clarke, J.A.; Hensen, J.L.M.; Johnstone, C.M.; McLean, R.C.

    1994-01-01

    This paper describes the recently revised curriculum for the Environmental Engineering course at the University of Strathclyde in Glasgow. This is done in relation to course content and scope, design and research projects, the role of experimentation and the deployment of advanced computing in terms

  6. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT: NEW CONDENSATOR, INC.--THE CONDENSATOR DIESEL ENGINE RETROFIT CRANKCASE VENTILATION SYSTEM

    Science.gov (United States)

    EPA's Environmental Technology Verification Program has tested New Condensator Inc.'s Condensator Diesel Engine Retrofit Crankcase Ventilation System. Brake specific fuel consumption (BSFC), the ratio of engine fuel consumption to the engine power output, was evaluated for engine...

  7. Idaho National Engineering and Environmental Laboratory site environmental report for calendar year 1997

    Energy Technology Data Exchange (ETDEWEB)

    Evans, R.B.; Brooks, R.W.; Roush, D.; Martin, D.B. [Environmental Science and Research Foundation, Idaho Falls, ID (United States); Lantz, B.S. [Dept. of Energy, Idaho Falls, ID (United States). Idaho Operations Office

    1998-08-01

    To verify that exposures resulting from operations at Department of Energy (DOE) nuclear facilities remain very small, each site at which nuclear activities are conducted operates an environmental surveillance program to monitor the air, water and any other pathway whereby radionuclides from operations might conceivably reach workers and members of the public. Environmental surveillance and monitoring results are reported annually to the DOE-Headquarters. This report presents a compilation of data collected in 1997 for the routine environmental surveillance programs conducted on and around the Idaho National Engineering and Environmental Laboratory (INEEL). The results of the various monitoring programs for 1997 indicated that radioactivity from the INEEL operations could generally not be distinguished from worldwide fallout and natural radioactivity in the region surrounding the INEEL. Although some radioactive materials were discharged during INEEL operations, concentrations in the offsite environment and doses to the surrounding population were far less than state of Idaho and federal health protection guidelines.

  8. Idaho National Engineering and Environmental Laboratory site environmental report for calendar year 1997

    International Nuclear Information System (INIS)

    Evans, R.B.; Brooks, R.W.; Roush, D.; Martin, D.B.; Lantz, B.S.

    1998-08-01

    To verify that exposures resulting from operations at Department of Energy (DOE) nuclear facilities remain very small, each site at which nuclear activities are conducted operates an environmental surveillance program to monitor the air, water and any other pathway whereby radionuclides from operations might conceivably reach workers and members of the public. Environmental surveillance and monitoring results are reported annually to the DOE-Headquarters. This report presents a compilation of data collected in 1997 for the routine environmental surveillance programs conducted on and around the Idaho National Engineering and Environmental Laboratory (INEEL). The results of the various monitoring programs for 1997 indicated that radioactivity from the INEEL operations could generally not be distinguished from worldwide fallout and natural radioactivity in the region surrounding the INEEL. Although some radioactive materials were discharged during INEEL operations, concentrations in the offsite environment and doses to the surrounding population were far less than state of Idaho and federal health protection guidelines

  9. Genetic organization of ascB-dapE internalin cluster serves as a potential marker for Listeria monocytogenes sublineages IIA, IIB, and IIC.

    Science.gov (United States)

    Chen, Jianshun; Fang, Chun; Zhu, Ningyu; Lv, Yonghui; Cheng, Changyong; Bei, Yijiang; Zheng, Tianlun; Fang, Weihuan

    2012-05-01

    Listeria monocytogenes is an important foodborne pathogen that comprises four genetic lineages: I, II, III, and IV. Of these, lineage II is frequently recovered from foods and environments and responsible for the increasing incidence of human listeriosis. In this study, the phylogenetic structure of lineage II was determined through sequencing analysis of the ascB-dapE internalin cluster. Fifteen sequence types proposed by multilocus sequence typing based on nine housekeeping genes were grouped into three distinct sublineages, IIA, IIB, and IIC. Organization of the ascBdapE internalin cluster could serve as a molecular marker for these sublineages, with inlGHE, inlGC2DE, and inlC2DE for IIA, IIB, and IIC, respectively. These sublineages displayed specific genetic and phenotypic characteristics. IIA and IIC showed a higher frequency of recombination (rho/theta). However, recombination events had greater effect (r/m) on IIB, leading to its high nucleotide diversity. Moreover, IIA and IIB harbored a wider range of internalin and stress-response genes, and possessed higher nisin tolerance, whereas IIC contained the largest portion of low-virulent strains owing to premature stop codons in inlA. The results of this study indicate that IIA, IIB, and IIC might occupy different ecological niches, and IIB might have a better adaptation to a broad range of environmental niches.

  10. Environmental engineering education enhancement

    Science.gov (United States)

    Caporali, E.

    2012-04-01

    Since higher education plays a central role in the development of both human beings and modern societies, enhancing social, cultural and economic development, active citizenship, ethical values and expertises for a sustainable growth, environment respectful, the European Commission promotes a wide range of programmes. Among the EC programmes, the TEMPUS - Trans European Mobility Programme for University Studies, with the support of the DG EAC of the European Commission, has contributed to many aspects of general interest for higher education. Curricula harmonization, LifeLong Learning Programme development, ICT use, quality assessment, accreditation, innovation learning methods, growth of networks of institutions trusting each other, are the focused aspects. Such a solid cooperation framework is surely among the main outcomes of the TEMPUS Projects leaded by the University of Firenze UNIFI (Italy), DEREC - Development of Environment and Resources Engineering Curriculum (2005-2008), and its spin-off DEREL - Development of Environment and Resources Engineering Learning (2010-2013), and VICES - Videoconferencing Educational Services (2009-2012). DEREC and DEREL TEMPUS projects, through the co-operation of Universities in Italy, Austria, Germany, Greece, Macedonia, Albania and Serbia, are aimed at the development of first and second level curricula in "Environment and Resources Engineering" at the Ss. Cyril and Methodius University - UKIM Skopje (MK). In the DEREC Project the conditions for offering a joint degree title in the field of Environmental Engineering between UNIFI and UKIM Skopje were fulfilled and a shared educational programme leading to the mutual recognition of degree titles was defined. The DEREL project, as logical continuation of DEREC, is aimed to introduce a new, up-to-date, postgraduate second level curriculum in Environment and Resources Engineering at UKIM Skopje, University of Novi Sad (RS) and Polytechnic University of Tirana (AL). following

  11. Environmental impact of offshore operation reduced using innovative engineering solutions

    International Nuclear Information System (INIS)

    Ritchie, C.J.; Wensel, E.A.; Edelblum, L.S.; Beal, D.

    1994-01-01

    The North Dauphin Island Tract 73 platform is located in eleven feet (3.4 m) of water and one mile (1.6 km) from shore in Mobile Bay, Alabama. The platform is designed to dehydrate and compress up to 70 MMSCFD (1.98 x 10 6 SM 3 ) from five remote gas production wells. Located near the city of Mobile, Alabama, the surrounding metropolitan and coastal areas has multiple uses including manufacturing, tourism, commercial and sport fishing, and wetlands and wildlife conservation. The multiple and interdependent economic uses of the area required that the platform be designed to minimize any adverse environmental impact. A cost-effective environmental engineering solution was desired at the design phase of the project. A water catchment, containment and disposal system was designed to meet the zero discharge requirement. Pollution from air emissions was reduced by the installation of lean burning engines. A floatover installation process was used to prevent dredging of the bay, thus protecting the bay water quality. An aesthetically concealing paint and lighting scheme was chosen and applied to the entire structure. These cost-effective engineering solutions during the design phase of the project saved time and money over the life of the project. All regulatory permits were obtained in a timely manner, with little or no opposition. The operator of the North Dauphin Island Development won several environmental awards due to the implementation of innovative solutions and their commitment to conservation of the natural environment

  12. R+D programme 'Environmental engineering'. R+D projects 1994. Data of September 1, 1994

    International Nuclear Information System (INIS)

    1994-01-01

    Research programmes of the Federal Republic of Germany in the field of environmental engineering are presented. Research is done in the fields of low-emission production processes, environmentally acceptable materials and products, and environmental analysis and measuring instruments. (SR) [de

  13. Optimizing the ASC WAN: evaluating network performance tools for comparing transport protocols.

    Energy Technology Data Exchange (ETDEWEB)

    Lydick, Christopher L.

    2007-07-01

    The Advanced Simulation & Computing Wide Area Network (ASC WAN), which is a high delay-bandwidth network connection between US Department of Energy National Laboratories, is constantly being examined and evaluated for efficiency. One of the current transport-layer protocols which is used, TCP, was developed for traffic demands which are different from that on the ASC WAN. The Stream Control Transport Protocol (SCTP), on the other hand, has shown characteristics which make it more appealing to networks such as these. Most important, before considering a replacement for TCP on any network, a testing tool that performs well against certain criteria needs to be found. In order to try to find such a tool, two popular networking tools (Netperf v.2.4.3 & v.2.4.6 (OpenSS7 STREAMS), and Iperf v.2.0.6) were tested. These tools implement both TCP and SCTP and were evaluated using four metrics: (1) How effectively can the tool reach a throughput near the bandwidth? (2) How much of the CPU does the tool utilize during operation? (3) Is the tool freely and widely available? And, (4) Is the tool actively developed? Following the analysis of those tools, this paper goes further into explaining some recommendations and ideas for future work.

  14. Mitigating Climate Change at the Carbon Water Nexus: A Call to Action for the Environmental Engineering Community.

    Science.gov (United States)

    Clarens, Andres F; Peters, Catherine A

    2016-10-01

    Environmental engineers have played a critical role in improving human and ecosystem health over the past several decades. These contributions have focused on providing clean water and air as well as managing waste streams and remediating polluted sites. As environmental problems have become more global in scale and more deeply entrenched in sociotechnical systems, the discipline of environmental engineering must grow to be ready to respond to the challenges of the coming decades. Here we make the case that environmental engineers should play a leadership role in the development of climate change mitigation technologies at the carbon-water nexus (CWN). Climate change, driven largely by unfettered emissions of fossil carbon into the atmosphere, is a far-reaching and enormously complex environmental risk with the potential to negatively affect food security, human health, infrastructure, and other systems. Solving this problem will require a massive mobilization of existing and innovative new technology. The environmental engineering community is uniquely positioned to do pioneering work at the CWN using a skillset that has been honed, solving related problems. The focus of this special issue, on "The science and innovation of emerging subsurface energy technologies," provides one example domain within which environmental engineers and related disciplines are beginning to make important contributions at the CWN. In this article, we define the CWN and describe how environmental engineers can bring their considerable expertise to bear in this area. Then we review some of the topics that appear in this special issue, for example, mitigating the impacts of hydraulic fracturing and geologic carbon storage, and we provide perspective on emergent research directions, for example, enhanced geothermal energy, energy storage in sedimentary formations, and others.

  15. Integration of project management and systems engineering: Tools for a total-cycle environmental management system

    International Nuclear Information System (INIS)

    Blacker, P.B.; Winston, R.

    1997-01-01

    An expedited environmental management process has been developed at the Idaho National Engineering and Environmental Laboratory (INEEL). This process is one result of the Lockheed Martin commitment to the US Department of Energy to incorporate proven systems engineering practices with project management and program controls practices at the INEEL. Lockheed Martin uses a graded approach of its management, operations, and systems activities to tailor the level of control to the needs of the individual projects. The Lockheed Martin definition of systems engineering is: ''''Systems Engineering is a proven discipline that defines and manages program requirements, controls risk, ensures program efficiency, supports informed decision making, and verifies that products and services meet customer needs.'''' This paper discusses: the need for an expedited environmental management process; how the system was developed; what the system is; what the system does; and an overview of key components of the process

  16. Department of Energy environmental management complex-wide integration using systems engineering

    International Nuclear Information System (INIS)

    Fairbourn, P.

    1997-01-01

    A systems engineering approach was successfully used to recommend changes to environmental management activities across the DOE Complex. A team of technical experts and systems engineers developed alternatives that could save tax payers billions of dollars if the barriers are removed to allow complete implementation. The alternatives are technically-based and defensible, and are being worked through the stakeholder review process. The integration process and implementing project structure are both discussed

  17. Scaffold preferences of mesenchymal stromal cells and adipose-derived stem cells from green fluorescent protein transgenic mice influence the tissue engineering of bone.

    Science.gov (United States)

    Wittenburg, Gretel; Flade, Viktoria; Garbe, Annette I; Lauer, Günter; Labudde, Dirk

    2014-05-01

    We have analysed the growth and differentiation of mesenchymal stromal cells (MSC) from bone marrow, and of adipose derived stem cells (ASC) from murine abdominal fat tissue, of green fluorescent protein (GFP) transgenic animals grown directly on two types of hydroxyapatite ceramic bone substitutes. BONITmatrix® and NanoBone® have specific mechanical and physiochemical properties such as porosity and an inner surface that influence cellular growth. Both MSC and ASC were separately seeded on 200mg of each biomaterial and cultured for 3 weeks under osteogenic differentiation conditions. The degree of mineralisation was assessed by alizarin red dye and the specific alkaline phosphatase activity of the differentiated cells. The morphology of the cells was examined by scanning electron microscopy and confocal microscopy. The osteoblastic phenotype of the cells was confirmed by analysing the expression of bone-specific genes (Runx2, osteocalcin, osteopontin, and osteonectin) by semiquantitative reverse transcriptase polymerase chain reaction (PCR). Comparison of BONITmatrix® and NanoBone® showed cell type-specific preferences in terms of osteogenic differentiation. MSC-derived osteoblast-like cells spread optimally on the surface of NanoBone® but not BONITmatrix® granules. In contrast BONITmatrix® granules conditioned the growth of osteoblast-like cells derived from ASC. The osteoblastic phenotype of the cultured cells on all matrices was confirmed by specific gene expression. Our results show that the in vitro growth and osteogenic differentiation of murine MSC or ASC of GFP transgenic mice are distinctly influenced by the ceramic substratum. While NanoBone® granules support the proliferation and differentiation of murine MSC isolated from bone marrow, the growth of murine ASC is supported by BONITmatrix® granules. NanoBone® is therefore recommended for use as scaffold in tissue engineering that requires MSC, whereas ASC can be combined with BONITmatrix® for

  18. Findings on Motivation and the Environmental Awareness and Practice of Future Engineers in Zagreb

    Directory of Open Access Journals (Sweden)

    Damir Milos

    2014-04-01

    Full Text Available This article is the result of a survey conducted on first year students of the Faculty of Mechanical Engineering and Naval Architecture in Zagreb. Heavy particles in the focus of this article are intrinsic and extrinsic motivation of students and their ecological awareness and practice. Accordingly, we wanted to examine which form of motivation was prevalent in students when choosing a career in engineering and the degree of environmental awareness and practice of those students. The results show that extrinsic elements of motivation were more important to students in terms of their future career. When it comes to environmental awareness and practices, results show a higher level of environmental awareness and practices among students. Conclusively, it can be noted that the dominance of extrinsic motivation for a career does not compromise the interest in environmental issues or environmental practices.

  19. Environmental restoration value engineering guidance document

    International Nuclear Information System (INIS)

    1995-07-01

    This document provides guidance on Value Engineering (VE). VE is an organized team effort led by a person trained in the methodology to analyze the functions of projects, systems, equipment, facilities, services, and processes for achieving the essential functions at the lowest life cycle cost while maintaining required performance, reliability, availability, quality, and safety. VE has proven to be a superior tool to improve up-front project planning, cut costs, and create a better value for each dollar spent. This document forms the basis for the Environmental Restoration VE Program, describes the VE process, and provides recommendations on when it can be most useful on ER projects

  20. The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.

    Directory of Open Access Journals (Sweden)

    Fabio Carrilho Galvão

    Full Text Available The putative eukaryotic translation initiation factor 5A (eIF5A is a highly conserved protein among archaea and eukaryotes that has recently been implicated in the elongation step of translation. eIF5A undergoes an essential and conserved posttranslational modification at a specific lysine to generate the residue hypusine. The enzymes deoxyhypusine synthase (Dys1 and deoxyhypusine hydroxylase (Lia1 catalyze this two-step modification process. Although several Saccharomyces cerevisiae eIF5A mutants have importantly contributed to the study of eIF5A function, no conditional mutant of Dys1 has been described so far. In this study, we generated and characterized the dys1-1 mutant, which showed a strong depletion of mutated Dys1 protein, resulting in more than 2-fold decrease in hypusine levels relative to the wild type. The dys1-1 mutant demonstrated a defect in total protein synthesis, a defect in polysome profile indicative of a translation elongation defect and a reduced association of eIF5A with polysomes. The growth phenotype of dys1-1 mutant is severe, growing only in the presence of 1 M sorbitol, an osmotic stabilizer. Although this phenotype is characteristic of Pkc1 cell wall integrity mutants, the sorbitol requirement from dys1-1 is not associated with cell lysis. We observed that the dys1-1 genetically interacts with the sole yeast protein kinase C (Pkc1 and Asc1, a component of the 40S ribosomal subunit. The dys1-1 mutant was synthetically lethal in combination with asc1Δ and overexpression of TIF51A (eIF5A or DYS1 is toxic for an asc1Δ strain. Moreover, eIF5A is more associated with translating ribosomes in the absence of Asc1 in the cell. Finally, analysis of the sensitivity to cell wall-perturbing compounds revealed a more similar behavior of the dys1-1 and asc1Δ mutants in comparison with the pkc1Δ mutant. These data suggest a correlated role for eIF5A and Asc1 in coordinating the translational control of a subset of m

  1. Genomic presence of gadD1 glutamate decarboxylase correlates with the organization of ascB-dapE internalin cluster in Listeria monocytogenes.

    Science.gov (United States)

    Chen, Jianshun; Fang, Chun; Zheng, Tianlun; Zhu, Ningyu; Bei, Yijiang; Fang, Weihuan

    2012-02-01

    The ability to survive and proliferate in acidic environments is a prerequisite for the infection of Listeria monocytogenes. The glutamate decarboxylase (GAD) system is responsible for acid resistance, and three GAD homologs have been identified in L. monocytogenes: gadD1, gadD2, and gadD3. To examine whether GAD genes are specific to lineage, serovar, or certain subpopulation, we performed a systematic investigation on the prevalence of GAD genes in 164 L. monocytogenes. In contrast to gadD2 and gadD3 conserved in all L. monocytogenes strains, gadD1 was identified in 36.6% (60/164) of L. monocytogenes strains, including all serovar 1/2c and 68.5% (37/54) of serovar 1/2a strains, as well as a small fraction of serovar 1/2b (3.4%, 1/29) and lineage III (13.8%, 4/29) strains. All serovar 4b and lineage IV strains lacked this gene. According to the ascB-dapE structure, L. monocytogenes strains were classified into four subpopulations, carrying inlC2DE, inlGC2DE, inlGHE, or no internalin cluster, respectively. All L. monocytogenes strains with inlGC2DE or inlGHE pattern harbored gadD1, whereas those bearing inlC2DE or no internalin cluster between ascB and dapE lacked gadD1. In addition, other five non-monocytogenes Listeria species lacking ascB-dapE internalin cluster were gadD1-negative. Overall, the presence of gadD1 is not fully dependent on lineages or serovars but correlates with ascB-dapE internalin profiles, suggesting gadD1 might have co-evolved with the ascB-dapE internalin cluster in the primitive L. monocytogenes before divergence of serovars.

  2. 76 FR 81485 - Chief of Engineers Environmental Advisory Board; Meeting

    Science.gov (United States)

    2011-12-28

    ... the potential effects of climate change. Following the discussions and presentations there will be a public comment period. FOR FURTHER INFORMATION CONTACT: Mr. John C. Furry, Designated Federal Officer... (202) 512-6000. Agenda: The Board will advise the Chief of Engineers on environmental policy...

  3. Report on the CESE (Council of Environmental Science and Engineering) conference: environmental effects of utilizing more coal

    Energy Technology Data Exchange (ETDEWEB)

    Lees, B.

    1980-03-01

    A review of a Council of Environmental Science and Engineering conference which looked at the consequences of increased amounts of coal being burned or converted into other products. The speakers and summaries of their papers are given.

  4. Consumo de ácido ascórbico y niveles séricos en hombres adultos fumadores y no fumadores de la CD. de Hermosillo, Sonora, México

    OpenAIRE

    Méndez E, Rosa Olivia; Wyatt, C. Jane; Saavedra, Javier; Ornelas, Alicia

    2002-01-01

    El ácido ascórbico es uno de las antioxidantes más importantes a nivel extracelular, sin embargo su papel preventivo de enfermedades degenerativas se puede comprometer al disminuir sus niveles séricos. Bajos valores de ácido ascórbico sérico se han reportado en hombres fumadores. En el presente estudio se estimó la ingestión de ácido ascórbico en 25 hombres adultos sanos de Hermosillo, Sonora, México, divididos en dos grupos: fumadores y no fumadores; se compararon los niveles séricos de ácid...

  5. Applied chemistry and environmental engineering for engineers. Manual for students and practicians. 2. ed.; Angewandte Chemie und Umwelttechnik fuer Ingenieure. Handbuch fuer Studium und betriebliche Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Fessmann, J.; Orth, H.

    2002-07-01

    This is a practically oriented textbook for chemistry and environmental protection training of students of mechanical engineering, vehicle engineering, electrical engineering, space HVAc engineering etc. Students are also given useful information on the practical applications of chemistry and on environmental protection in industrial practice. The book also contains problem solutions for managing engineers in organizations of the metal and electrical branch who are confronted with chemical problems in chemical engineering, quality assurance, industrial safety and environmental protection. [German] Das Handbuch vermittelt in konzentrierter Form die Grundlagen der Chemie und Umwelttechnik und schlaegt rasch die Bruecke zur industriellen Anwendung bevorzugt in der Metall- und Elektroindustrie. Das Handbuch ist ein praxisorientiertes Lehrbuch fuer die Chemie- und Umweltschutzausbildung von Ingenieurstudenten der Fachrichtungen Maschinenbau, Fahrzeugtechnik, Elektrotechnik, Versorgungstechnik u.a. Darueberhinaus finden Schueler von Chemieleistungskursen an Gymnasien oder Chemiestudenten an Fachhochschulen oder Universitaeten viele nuetzliche Informationen ueber die Anwendungen von Chemie und Umweltschutz in der industriellen Praxis. Nicht zuletzt enthaelt das Buch Problemloesungen fuer Betriebsingenieure, insbesondere aus dem Bereich der Metall- und Elektrobranche, die mit chemischen Fragestellungen in der Verfahrenstechnik, Qualitaetssicherung oder Arbeits-/Umweltschutzueberwachung konfrontiert sind. (orig.)

  6. Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+) using HPV DNA testing after a diagnosis of atypical squamous cell of undetermined significance (ASC-US) in Catalonia, Spain.

    Science.gov (United States)

    Ibáñez, Raquel; Moreno-Crespi, Judit; Sardà, Montserrat; Autonell, Josefina; Fibla, Montserrat; Gutiérrez, Cristina; Lloveras, Belen; Alejo, María; Català, Isabel; Alameda, Francesc; Casas, Miquel; Bosch, F Xavier; de Sanjosé, Silvia

    2012-01-26

    A protocol for cervical cancer screening among sexually active women 25 to 65 years of age was introduced in 2006 in Catalonia, Spain to increase coverage and to recommend a 3-year-interval between screening cytology. In addition, Human Papillomavirus (HPV) was offered as a triage test for women with a diagnosis of atypical squamous cells of undetermined significance (ASC-US). HPV testing was recommended within 3 months of ASC-US diagnosis. According to protocol, HPV negative women were referred to regular screening including a cytological exam every 3 years while HPV positive women were referred to colposcopy and closer follow-up. We evaluated the implementation of the protocol and the prediction of HPV testing as a triage tool for cervical intraepithelial lesions grade two or worse (CIN2+) in women with a cytological diagnosis of ASC-US. During 2007-08 a total of 611 women from five reference laboratories in Catalonia with a novel diagnosis of ASC-US were referred for high risk HPV (hrHPV) triage using high risk Hybrid Capture version 2. Using routine record linkage data, women were followed for 3 years to evaluate hrHPV testing efficacy for predicting CIN2+ cases. Logistic regression analysis was used to estimate the odds ratio for CIN2 +. Among the 611 women diagnosed with ASC-US, 493 (80.7%) had at least one follow-up visit during the study period. hrHPV was detected in 48.3% of the women at study entry (mean age 35.2 years). hrHPV positivity decreased with increasing age from 72.6% among women younger than 25 years to 31.6% in women older than 54 years (p < 0.01). At the end of the 3 years follow-up period, 37 women with a diagnosis of CIN2+ (18 CIN2, 16 CIN3, 2 cancers, and 1 with high squamous intraepithelial lesions--HSIL) were identified and all but one had a hrHPV positive test at study entry. Sensitivity to detect CIN2+ of hrHPV was 97.2% (95%confidence interval (CI) = 85.5-99.9) and specificity was 68.3% (95%CI = 63.1-73.2). The odds ratio for CIN2

  7. ASC-J9 Suppresses Castration-Resistant Prostate Cancer Growth through Degradation of Full-length and Splice Variant Androgen Receptors

    Directory of Open Access Journals (Sweden)

    Shinichi Yamashita

    2012-01-01

    Full Text Available Early studies suggested androgen receptor (AR splice variants might contribute to the progression of prostate cancer (PCa into castration resistance. However, the therapeutic strategy to target these AR splice variants still remains unresolved. Through tissue survey of tumors from the same patients before and after castration resistance, we found that the expression of AR3, a major AR splice variant that lacks the AR ligand-binding domain, was substantially increased after castration resistance development. The currently used antiandrogen, Casodex, showed little growth suppression in CWR22Rv1 cells. Importantly, we found that AR degradation enhancer ASC-J9 could degrade both full-length (fAR and AR3 in CWR22Rv1 cells as well as in C4-2 and C81 cells with addition of AR3. The consequences of such degradation of both fAR and AR3 might then result in the inhibition of AR transcriptional activity and cell growth in vitro. More importantly, suppression of AR3 specifically by short-hairpin AR3 or degradation of AR3 by ASC-J9 resulted in suppression of AR transcriptional activity and cell growth in CWR22Rv1-fARKD (fAR knockdown cells in which DHT failed to induce, suggesting the importance of targeting AR3. Finally, we demonstrated the in vivo therapeutic effects of ASC-J9 by showing the inhibition of PCa growth using the xenografted model of CWR22Rv1 cells orthotopically implanted into castrated nude mice with undetectable serum testosterone. These results suggested that targeting both fAR- and AR3-mediated PCa growth by ASC-J9 may represent the novel therapeutic approach to suppress castration-resistant PCa. Successful clinical trials targeting both fAR and AR3 may help us to battle castration-resistant PCa in the future.

  8. Introducing Ethical, Social and Environmental Issues in ICT Engineering Degrees

    Science.gov (United States)

    Miñano, Rafael; Aller, Celia Fernández; Anguera, Áurea; Portillo, Eloy

    2015-01-01

    This paper describes the experience of introducing ethical, social and environmental issues in undergraduate ICT engineering degrees at the Universidad Politécnica de Madrid. The experience before the Bologna Process was concentrated on developing elective courses related mainly on the field of the International Development Cooperation. The…

  9. Engineering Task Plan to Expand the Environmental Operational Envelope of Core Sampling

    International Nuclear Information System (INIS)

    BOGER, R.M.

    1999-01-01

    This Engineering Task Plan authorizes the development of an Alternative Generation and Analysis (AGA). The AGA will determine how to expand the environmental operating envelope during core sampling operations

  10. Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+ using HPV DNA testing after a diagnosis of atypical squamous cell of undetermined significance (ASC-US in Catalonia, Spain

    Directory of Open Access Journals (Sweden)

    Ibáñez Raquel

    2012-01-01

    Full Text Available Abstract Background A protocol for cervical cancer screening among sexually active women 25 to 65 years of age was introduced in 2006 in Catalonia, Spain to increase coverage and to recommend a 3-year-interval between screening cytology. In addition, Human Papillomavirus (HPV was offered as a triage test for women with a diagnosis of atypical squamous cells of undetermined significance (ASC-US. HPV testing was recommended within 3 months of ASC-US diagnosis. According to protocol, HPV negative women were referred to regular screening including a cytological exam every 3 years while HPV positive women were referred to colposcopy and closer follow-up. We evaluated the implementation of the protocol and the prediction of HPV testing as a triage tool for cervical intraepithelial lesions grade two or worse (CIN2+ in women with a cytological diagnosis of ASC-US. Methods During 2007-08 a total of 611 women from five reference laboratories in Catalonia with a novel diagnosis of ASC-US were referred for high risk HPV (hrHPV triage using high risk Hybrid Capture version 2. Using routine record linkage data, women were followed for 3 years to evaluate hrHPV testing efficacy for predicting CIN2+ cases. Logistic regression analysis was used to estimate the odds ratio for CIN2 +. Results Among the 611 women diagnosed with ASC-US, 493 (80.7% had at least one follow-up visit during the study period. hrHPV was detected in 48.3% of the women at study entry (mean age 35.2 years. hrHPV positivity decreased with increasing age from 72.6% among women younger than 25 years to 31.6% in women older than 54 years (p At the end of the 3 years follow-up period, 37 women with a diagnosis of CIN2+ (18 CIN2, 16 CIN3, 2 cancers, and 1 with high squamous intraepithelial lesions -HSIL were identified and all but one had a hrHPV positive test at study entry. Sensitivity to detect CIN2+ of hrHPV was 97.2% (95%confidence interval (CI = 85.5-99.9 and specificity was 68.3% (95%CI

  11. Introducing Molecular Biology to Environmental Engineers through Development of a New Course.

    Science.gov (United States)

    Oerther, Daniel B.

    2002-01-01

    Introduces a molecular biology course designed for environmental engineering majors using 16S ribosomal ribonucleic acid-targeted technology that allows students to identify and study microorganisms in bioreactor environments. (Contains 17 references.) (YDS)

  12. Evaporation Basin Test Reactor Area, Idaho National Engineering Laboratory: Environmental assessment

    International Nuclear Information System (INIS)

    1991-12-01

    The Department of Energy (DOE) has prepared an environmental assessment (EA), DOE/EA-0501, on the construction and operation of the proposed Evaporation Basin at the Test Reactor Area (TRA) at the Idaho National Engineering Laboratory (INEL) near Idaho Falls, Idaho. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement (EIS) is not required, and the Department is issuing this Finding of No Significant Impact

  13. Antocianinas, ácido ascórbico, polifenoles totales y actividad antioxidante, en la cáscara de camu-camu (Myrciaria dubia (H.B.K McVaugh Antocianinas, ácido ascórbico, polifenóis totais e atividade antioxidante na casca do camu-camu (Myrciaria dubia (H.B.K McVaugh

    Directory of Open Access Journals (Sweden)

    Juan Edson Villanueva-Tiburcio

    2010-05-01

    Full Text Available Este trabajo fue realizado en la UNAS, Tingo María, Perú. Los objetivos fueron evaluar el contenido de antocianinas, ácido ascórbico, y polifenoles totales, en la cáscara fresca y seca de camu-camu (Myrciaria dubia (H.B.K McVaugh en diferentes estados de madurez; evaluar la actividad antioxidante en la cáscara seca, usando diferentes tipos de radicales (DPPH, ABTS+ y Peroxilo y correlacionar el valor de ácido ascórbico y polifenoles totales con la actividad antioxidante. La extracción fue realizada en medio acuoso, y los resultados de las evaluaciones de cada experimento fueron analizados por un diseño completamente al azar (DCA, según la prueba de t-student (p A pesquisa foi realizada na UNAS em Tingo Maria, Peru, teve como objetivos: avaliar o teor de antocianinas, ácido ascórbico e polifenóis totais, na casca fresca e na casca seca do camu-camu (Myrciaria dubia (HBK McVaugh em diferentes tempos de maturação; avaliar a atividade antioxidante na casca seca utilizando diferentes tipos de radicais (DPPH, ABTS+ e Peroxilo e correlacionar o teor de ácido ascórbico e polifenóis totais com a atividade antioxidante. A extraç��o foi realizada em meio aquoso, os resultados das avaliações de cada experiência são analisados no delineamento inteiramente casualizado (DIC, pelo teste de t-student (p < 0,05. O extrato da casca da amostra madura fresca apresentou as concentrações mais elevadas de ácido ascórbico e de antocianinas em relação a meio madura e verde, com 21,95 mg.g-1 de casca e 46,42 mg.L-1 de cianidin-3-glucosídeo, respectivamente, enquanto que o extrato da casca seca meio madura apresentou o maior teor de ácido ascórbico em relação a madura e verde (53,49 mg.g-1 e de polifenóis totais: 7,70 mg Ác. Gálico/g. A maior atividade antioxidante foi encontrada no extrato da casca seca da amostra meio madura com IC50 = 46,20; 20,25 e 8,30 μg.mL-1, em comparação com DPPH radical, ABTS+ e Perox

  14. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells.

    Science.gov (United States)

    Wang, Chen; Guo, Fangfang; Zhou, Heng; Zhang, Yun; Xiao, Zhigang; Cui, Lei

    2013-02-01

    Adipose-derived stem cells (ASCs) can differentiate into smooth muscle cells and have been engineered into elastic small diameter blood vessel walls in vitro. However, the mechanisms involved in the development of three-dimensional (3D) vascular tissue remain poorly understood. The present study analyzed protein expression profiles of engineered blood vessel walls constructed by human ASCs using methods of two-dimensional gel electrophoresis (2DE) and mass spectrometry (MS). These results were compared to normal arterial walls. A total of 1701±15 and 1265±26 protein spots from normal and engineered blood vessel wall extractions were detected by 2DE, respectively. A total of 20 spots with at least 2.0-fold changes in expression were identified, and 38 differently expressed proteins were identified by 2D electrophoresis and ion trap MS. These proteins were classified into seven functional categories: cellular organization, energy, signaling pathway, enzyme, anchored protein, cell apoptosis/defense, and others. These results demonstrated that 2DE, followed by ion trap MS, could be successfully utilized to characterize the proteome of vascular tissue, including tissue-engineered vessels. The method could also be employed to achieve a better understanding of differentiated smooth muscle protein expression in vitro. These results provide a basis for comparative studies of protein expression in vascular smooth muscles of different origin and could provide a better understanding of the mechanisms of action needed for constructing blood vessels that exhibit properties consistent with normal blood vessels.

  15. Environmental Aspects of the Engineering Training at Technical University

    Directory of Open Access Journals (Sweden)

    V. V. Bushueva

    2015-01-01

    Full Text Available Problem relevance. The article gives a justification for a need to train professionally competent, ecologically oriented engineers capable to create new equipment taking into account the ecological characteristics. Such approach expresses a requirement coherence to develop technical systems and technologies taking into account, both technical reliability and human and environmental safety. Today, in conditions of modern industrial production it is an important point in engineer’s activity. So to train future engineers who meet these requirements new forms and methods are to be found.Objectives. To prove that involvement of creative student’s teams in training the future ecologically oriented engineers is of importance. The organisational structure and methods of activities along with the principles of revitalizing search for engineering ideas and solutions to develop environmentally safe technical systems and technologies allow us to solve more complicated problems. This is the important characteristic in activities of creative groups. The article considers a significance of the future engineer’s responsibility in terms of environment safety. It gives "Methodical advices to analyse the operational impacts of technical systems on the human and environment" to show that there is a need in development of reliable and environment-safe technical systems.Novelty of this work is a technique for the organization and forms of student creative team’s activities. It represents a revised and updated option of a technique of the creative teams working at the industrial enterprises in France. The revised technique takes into consideration both the specifics of student's audience at technical university and the environment-oriented tasks to be solved. Efficiency of search and solution of environment-oriented engineering tasks is enhanced owing to use of revitalizing methods for the creative team’s activities, which are widely used today in student

  16. Evaluation of engineered barriers at the Idaho National Engineering and Environmental Laboratory

    International Nuclear Information System (INIS)

    Bhatt, R.N.; Porro, I.

    1998-03-01

    Subsurface Disposal (SDA) of the Radioactive Waste Management Complex serves as the low level waste burial ground at the Idaho National Engineering and Environmental Laboratory (INEEL). The low level wastes are buried in trenches, pits, and soil vaults in surficial sediments. A closure/post-closure plan must be written prior to closure of the SDA. The closure plan for the facility must include a design for an engineered barrier closure cover that will meet all applicable regulatory requirements. This paper describes the approach being followed at the INEEL to choose an appropriate cover design for the SDA closure. Regulatory requirements and performance objectives potentially applicable to closure of the SDA were identified. Technical issues related to SDA closure were identified from a literature search of previous arid site engineered barrier studies and from previous SDA closure cover evaluations. Five engineered barrier conceptual design alternatives were identified: (1) a bio/capillary barrier cover, (2) a thin soil cover, (3) a thick soil cover, (4) a Resource Conservation and Recovery Act cover, and (5) a concrete sealed surface cover. Two of these designs were chosen for in situ hydraulic testing, rather than all five, in order to maximize the amount of information generated relative to projected project costs. Testing of these two cover designs provides data to quantify hydrologic model input parameters and for verification of site specific hydrologic models for long term closure cover performance evaluation and detailed analysis of closure cover alternatives. The specific objectives of the field tests are to determine the water balance for the two covers over several years and to determine cover soil physical and hydraulic properties

  17. Report of experiments and evidence for ASC L2 milestone 4467 : demonstration of a legacy application's path to exascale.

    Energy Technology Data Exchange (ETDEWEB)

    Curry, Matthew L.; Ferreira, Kurt Brian; Pedretti, Kevin Thomas Tauke; Leung, Vitus Joseph; Moreland, Kenneth D.; Lofstead, Gerald Fredrick, II; Gentile, Ann C. (Sandia National Laboratories, Livermore, CA); Klundt, Ruth Ann; Ward, H. Lee; Laros, James H., III; Hemmert, Karl Scott; Fabian, Nathan D.; Levenhagen, Michael J.; Barrett, Brian W.; Brightwell, Ronald Brian; Barrett, Richard; Wheeler, Kyle Bruce; Kelly, Suzanne Marie; Rodrigues, Arun F.; Brandt, James M. (Sandia National Laboratories, Livermore, CA); Thompson, David (Sandia National Laboratories, Livermore, CA); VanDyke, John P.; Oldfield, Ron A.; Tucker, Thomas (Open Grid Computing, Inc., Austin, TX); Vaughan, Courtenay Thomas

    2012-03-01

    This report documents thirteen of Sandia's contributions to the Computational Systems and Software Environment (CSSE) within the Advanced Simulation and Computing (ASC) program between fiscal years 2009 and 2012. It describes their impact on ASC applications. Most contributions are implemented in lower software levels allowing for application improvement without source code changes. Improvements are identified in such areas as reduced run time, characterizing power usage, and Input/Output (I/O). Other experiments are more forward looking, demonstrating potential bottlenecks using mini-application versions of the legacy codes and simulating their network activity on Exascale-class hardware. The purpose of this report is to prove that the team has completed milestone 4467-Demonstration of a Legacy Application's Path to Exascale. Cielo is expected to be the last capability system on which existing ASC codes can run without significant modifications. This assertion will be tested to determine where the breaking point is for an existing highly scalable application. The goal is to stretch the performance boundaries of the application by applying recent CSSE RD in areas such as resilience, power, I/O, visualization services, SMARTMAP, lightweight LWKs, virtualization, simulation, and feedback loops. Dedicated system time reservations and/or CCC allocations will be used to quantify the impact of system-level changes to extend the life and performance of the ASC code base. Finally, a simulation of anticipated exascale-class hardware will be performed using SST to supplement the calculations. Determine where the breaking point is for an existing highly scalable application: Chapter 15 presented the CSSE work that sought to identify the breaking point in two ASC legacy applications-Charon and CTH. Their mini-app versions were also employed to complete the task. There is no single breaking point as more than one issue was found with the two codes. The results were

  18. Surface Immobilization of Engineered Nanomaterials for in Situ Study of their Environmental Transformations and Fate

    Science.gov (United States)

    The transformation and environmental fate of engineered nanomaterials (ENMs) is the focus of intense research due to concerns about their potential impacts in the environment as a result of their uniquely engineered properties. Many approaches are being applied to investigate th...

  19. Determinação das constantes cinéticas de degradação do ácido ascórbico em purê de pêssego: efeito da temperatura e concentração

    OpenAIRE

    Toralles,Ricardo Peraça; Vendruscolo,João Luiz; Vendruscolo,Claire Tondo; Del Pino,Francisco Augusto Burkert; Antunes,Pedro Luiz

    2008-01-01

    O ácido ascórbico, vitamina C, é usado extensivamente na indústria de alimentos, não só devido ao seu valor nutricional, mas devido a suas contribuições funcionais na qualidade do produto. Existem muitos estudos sobre a estabilidade cinética do ácido ascórbico em bebidas, mas nenhum estudo foi encontrado sobre as constantes cinéticas de degradação do ácido ascórbico adicionado em purê de pêssego. Neste trabalho, estudou-se a cinética de degradação do ácido ascórbico em purê de pêssego da cult...

  20. Integrating Sustainable Development in Chemical Engineering Education: The Application of an Environmental Management System

    Science.gov (United States)

    Montanes, M. T.; Palomares, A. E.; Sanchez-Tovar, R.

    2012-01-01

    The principles of sustainable development have been integrated in chemical engineering education by means of an environmental management system. These principles have been introduced in the teaching laboratories where students perform their practical classes. In this paper, the implementation of the environmental management system, the problems…

  1. Establishment of first engineering specifications for environmental modification to eliminate schistosomiasis epidemic foci in urban areas.

    Science.gov (United States)

    Kong, Shibo; Tan, Xiaodong; Deng, Zhiqing; Xie, Yaofei; Yang, Fen; Zheng, Zengwang

    2017-08-01

    Snail control is a key link in schistosomiasis control, but no unified methods for eliminating snails have been produced to date. This study was conducted to explore an engineering method for eliminating Oncomelania hupensis applicable to urban areas. The engineering specifications were established using the Delphi method. An engineering project based on these specifications was conducted in Hankou marshland to eliminate snails, including the transformation of the beach surface and ditches. Molluscicide was used as a supplement. The snail control effect was evaluated by field investigation. The engineering results fulfilled the requirements of the design. The snail density decreased to 0/0.11m 2 , and the snail area dropped to 0m 2 after the project. There was a statistically significant difference in the number of frames with snails before and after the project (Pengineering specifications for environmental modification were successfully established. Environmental modification, mainly through beach and ditch remediation, can completely change the environment of Oncomelania breeding. This method of environmental modification combined with mollusciciding was highly effective at eliminating snails. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Carbon storage in the Mississippi River delta enhanced by environmental engineering

    Science.gov (United States)

    Shields, Michael R.; Bianchi, Thomas S.; Mohrig, David; Hutchings, Jack A.; Kenney, William F.; Kolker, Alexander S.; Curtis, Jason H.

    2017-11-01

    River deltas have contributed to atmospheric carbon regulation throughout Earth history, but functioning in the modern era has been impaired by reduced sediment loads, altered hydrologic regimes, increased global sea-level rise and accelerated subsidence. Delta restoration involves environmental engineering via river diversions, which utilize self-organizing processes to create prograding deltas. Here we analyse sediment cores from Wax Lake delta, a product of environmental engineering, to quantify the burial of organic carbon. We find that, despite relatively low concentrations of organic carbon measured in the cores (about 0.4%), the accumulation of about 3 T m-2 of sediment over the approximate 60 years of delta building resulted in the burial of a significant amount of organic carbon (16 kg m-2). This equates to an apparent organic carbon accumulation rate of 250 +/- 23 g m-2 yr-1, which implicitly includes losses by carbon emissions and erosion. Our estimated accumulation rate for Wax Lake delta is substantially greater than previous estimates based on the top metre of delta sediments and comparable to those of coastal mangrove and marsh habitats. The sedimentation of carbon at the Wax Lake delta demonstrates the capacity of engineered river diversions to enhance both coastal accretion and carbon burial.

  3. Incorporating geoethics into environmental engineering lectures - three years of experience from international students visiting Iceland

    Science.gov (United States)

    Finger, David C.

    2017-04-01

    Never before has human kind been facing bigger environmental challenges than today. The challenges are overwhelming: growing human population, increasing ecological footprints, accelerated climate change, severe soil degradation, eutrophication of vital fresh water resources, acidification of oceans, health threatening air pollution and rapid biodiversity loss, to name just a few. It is the task of environmental scientists to transmit established knowledge on these complex and interdisciplinary challenges while demonstrating that management and engineering solutions exist to meet these threats. In this presentation I will outline the concept of my environmental impact (EI) assessment course, where prospective engineering students can select a topic of their choice, assess the environmental impacts, discuss with relevant stakeholders and come up with innovative solutions. The course is structured in three parts: i) lecturing of theoretical methods frequently used within the EI assessment process, ii) interaction with local businesses to acquire first-hand experience and iii) hands on training by writing an EI statement on a selected topic (see link below). Over the course of three years over 70 prospective engineering students from all over the world have not only acquired environmental system understanding, but also enhanced their awareness and developed potential solutions to mitigate, compensate and reverse the persistent environmental challenges. Most importantly, during this process all involved stakeholders (students, teachers, industry partners, governmental bodies and NGO partners) will hopefully develop a mutual understanding of the above mentioned environmental challenges and engage in an open and constructive dialogue necessary to generate acceptable solutions. Link to student projects from previous years: https://fingerd.jimdo.com/teaching/courses/environmental-impact-assessment/

  4. Comprehensive probabilistic modelling of environmental emissions of engineered nanomaterials.

    Science.gov (United States)

    Sun, Tian Yin; Gottschalk, Fadri; Hungerbühler, Konrad; Nowack, Bernd

    2014-02-01

    Concerns about the environmental risks of engineered nanomaterials (ENM) are growing, however, currently very little is known about their concentrations in the environment. Here, we calculate the concentrations of five ENM (nano-TiO2, nano-ZnO, nano-Ag, CNT and fullerenes) in environmental and technical compartments using probabilistic material-flow modelling. We apply the newest data on ENM production volumes, their allocation to and subsequent release from different product categories, and their flows into and within those compartments. Further, we compare newly predicted ENM concentrations to estimates from 2009 and to corresponding measured concentrations of their conventional materials, e.g. TiO2, Zn and Ag. We show that the production volume and the compounds' inertness are crucial factors determining final concentrations. ENM production estimates are generally higher than a few years ago. In most cases, the environmental concentrations of corresponding conventional materials are between one and seven orders of magnitude higher than those for ENM. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Efeito do ácido ascórbico em massa de pão na presença do ácido tânico - doi: 10.4025/actascitechnol.v32i2.5290

    Directory of Open Access Journals (Sweden)

    Ana Leticia Gomes Saraiva

    2010-07-01

    Full Text Available Pães de farinha de trigo com adição do agente oxidante ácido ascórbico foram elaborados, tentando-se encontrar a concentração de ácido tânico que melhor retivesse o ácido ascórbico, sem afetar significativamente as características reológicas e os principais atributos sensoriais do pão. Os pães foram elaborados com a formulação de pão-padrão. Na primeira etapa, determinou-se a concentração de ácido ascórbico que melhor proporcionasse estabilidade à massa de pão-padrão (300 ppm. Na etapa seguinte, foram utilizadas na formulação da massa-padrão três concentrações diferentes de ácido tânico: 0,10; 0,20 e 0,30%, com a finalidade de se verificar a concentração que melhor retivesse o ácido ascórbico. Os pães foram elaborados com a formulação-padrão. Após o resfriamento dos pães, foi avaliada a retenção de ácido ascórbico, presente no pão de acordo com a concentração previamente determinada. Os resultados indicaram que o pão elaborado com a massa de pão-padrão (300 ppm de ácido ascórbico apresentou concentração de ácido ascórbico de 41,50 mg 100 g-1 de pão.

  6. Observaciones histopatologicas de juveniles penaeus vannamei sometidos a dietas artificiales con diferentes concentraciones de una sal de ácido ascórbico (vitamina c)

    OpenAIRE

    Vera Muñoz, L.

    1995-01-01

    Observaciones histopatologicas de juveniles Penaeus Vannamei sometidos a dietas artificiales con diferentes concentraciones de una sal de ácido ascórbico (vitamina C) Se realizaron análisis histológicos y comprobación mediante métodos histoquímicos de la presencia de melanina, a juveniles Penaeus vannamei sometidos a cinco dietas experimentales con diferentes concentraciones de una sal de L-Ascorbato-2-Fosfato de Mg (APM) usada como fuente de ácido ascórbico (AA).

  7. Clinical significance of HPV DNA cotesting in Korean women with ASCUS or ASC-H.

    Science.gov (United States)

    Lee, Sanghoon; Kim, Jae Won; Hong, Jin Hwa; Song, Jae Yun; Lee, Jae Kwan; Kim, In Sun; Lee, Nak Woo

    2014-12-01

    The purpose of this study was to evaluate the clinical significance of Human papillomavirus (HPV) DNA cotesting in Korean women with abnormal Papanicolaou (Pap) smear results based on colposcopic pathology. A total of 1012 women underwent liquid-based Pap smears and hybrid capture II HPV DNA tests followed by colposcopy at the Korea University Hospital from January 2007 to May 2012. Of these women, 832 women were included in this retrospective study. The mean patient age was 45.4 ± 13.7 years (range:15-80). The distribution of Pap smear results was normal (4.7%), atypical squamous cells of uncertain significance (ASCUS) (42.1%), low-grade squamous intraepithelial lesion (26.8%), ASC-H (7.0%), and high-grade squamous intraepithelial lesion (HSIL) (19.5%). In women with ASCUS, none of the 87 HPV-negative had ≥cervical intraepithelial neoplasia (CIN2) (P age groups: ASCUS and ASC-H furnish healthcare providers with informative data. There is a lower proportion of ≥CIN2 in HPV-negative women and a higher proportion of ≥CIN2 in HPV-positive. When HPV data were further evaluated by age group, the risk of ≥CIN2 was lower in HPV-negative women, especially in women ≥30. © 2014 Wiley Periodicals, Inc.

  8. Effects of Metal Micro and Nano-Particles on hASCs: An In Vitro Model.

    Science.gov (United States)

    Palombella, Silvia; Pirrone, Cristina; Rossi, Federica; Armenia, Ilaria; Cherubino, Mario; Valdatta, Luigi; Raspanti, Mario; Bernardini, Giovanni; Gornati, Rosalba

    2017-08-03

    As the knowledge about the interferences of nanomaterials on human staminal cells are scarce and contradictory, we undertook a comparative multidisciplinary study based on the size effect of zero-valent iron, cobalt, and nickel microparticles (MPs) and nanoparticles (NPs) using human adipose stem cells (hASCs) as a model, and evaluating cytotoxicity, morphology, cellular uptake, and gene expression. Our results suggested that the medium did not influence the cell sensitivity but, surprisingly, the iron microparticles (FeMPs) resulted in being toxic. These data were supported by modifications in mRNA expression of some genes implicated in the inflammatory response. Microscopic analysis confirmed that NPs, mainly internalized by endocytosis, persist in the vesicles without any apparent cell damage. Conversely, MPs are not internalized, and the effects on hASCs have to be ascribed to the release of ions in the culture medium, or to the reduced oxygen and nutrient exchange efficiency due to the presence of MP agglomerating around the cells. Notwithstanding the results depicting a heterogeneous scene that does not allow drawing a general conclusion, this work reiterates the importance of comparative investigations on MPs, NPs, and corresponding ions, and the need to continue the thorough verification of NP and MP innocuousness to ensure unaffected stem cell physiology and differentiation.

  9. Challenges and Opportunities for Establishing Design as a Research Discipline in Civil and Environmental Engineering

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn

    2013-01-01

    faculty, research and education communities, conferences, and journals. However, design remains an emerging sub-discipline in civil and environmental engineering – practiced, valued, and taught but not subject to rigorous academic research. This paper presents some of the challenges associated...... with the establishment of design as a research discipline within civil and environmental engineering, some of the benefits and opportunities that will come from that establishment, and some evidence for the fact that this process has already begun.......There are a number of fields including architecture, industrial design, and urban planning and design, where design is the discipline upon which all research and teaching activities are based. In other fields such as aerospace and mechanical engineering, design is a sub-discipline with its own...

  10. Space Station Environmental Control/Life Support System engineering

    Science.gov (United States)

    Miller, C. W.; Heppner, D. B.

    1985-01-01

    The present paper is concerned with a systems engineering study which has provided an understanding of the overall Space Station ECLSS (Environmental Control and Life Support System). ECLSS/functional partitioning is considered along with function criticality, technology alternatives, a technology description, single thread systems, Space Station architectures, ECLSS distribution, mechanical schematics per space station, and Space Station ECLSS characteristics. Attention is given to trade studies and system synergism. The Space Station functional description had been defined by NASA. The ECLSS will utilize technologies which embody regenerative concepts to minimize the use of expendables.

  11. Idaho National Engineering Laboratory site environmental report for calendar year 1995

    International Nuclear Information System (INIS)

    Mitchell, R.G.; Peterson, D.; Hoff, D.L.

    1996-08-01

    This report presents a compilation of data collected in 1995 for the routine environmental surveillance programs conducted on and around the Idaho National Engineering Laboratory (INEL). During 1995, the offsite surveillance program was conducted by the Environmental Science and Research Foundation. Onsite surveillance was performed by Lockheed Idaho Technologies Company (LITCO). Ground-water monitoring, both on and offsite, was performed by the US Geological Survey (USGS). This report also presents summaries of facility effluent monitoring data collected by INEL contractors. This report, prepared in accordance with the requirements in DOE Order 5400.1, is not intended to cover the numerous special environmental research programs being conducted at the INEL by the Foundation, LITCO, USGS, and others

  12. Idaho National Engineering Laboratory site environmental report for calendar year 1995

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, R.G.; Peterson, D.; Hoff, D.L.

    1996-08-01

    This report presents a compilation of data collected in 1995 for the routine environmental surveillance programs conducted on and around the Idaho National Engineering Laboratory (INEL). During 1995, the offsite surveillance program was conducted by the Environmental Science and Research Foundation. Onsite surveillance was performed by Lockheed Idaho Technologies Company (LITCO). Ground-water monitoring, both on and offsite, was performed by the US Geological Survey (USGS). This report also presents summaries of facility effluent monitoring data collected by INEL contractors. This report, prepared in accordance with the requirements in DOE Order 5400.1, is not intended to cover the numerous special environmental research programs being conducted at the INEL by the Foundation, LITCO, USGS, and others.

  13. Environmental education and socioresponsive engineering. Report of an educational initiative in Hyderabad, India.

    Science.gov (United States)

    Ansari, Ali Uddin; Jafari, Ashfaque; Mirzana, Ishrat Meera; Imtiaz, Zulfia; Lukacs, Heather

    2003-07-01

    A recent initiative at Muffakham Jah College of Engineering and Technology, Hyderabad, India, has resulted in setting up a program called Centre for Environment Studies and Socioresponsive Engineering which seeks to involve undergraduate students in studying and solving environmental problems in and around the city of Hyderabad, India. Two pilot projects have been undertaken--one focusing on design and construction of an eco-friendly house, The Natural House, and another directed at improving environmental and general living conditions in a slum area. The paper describes our attempts and experience of motivating our students to take interest in such projects. In an interesting development we invited a member of a student-faculty team at Massachusetts Institute of Technology (M.I.T.) that is doing a project in Nepal on safe drinking water. We report in our paper how the presentation by the guest from M.I.T. served as a catalyst for generating interest among civil and mechanical engineering students in our own projects. The paper includes contributions from one of our students and the M.I.T. staff member, reporting on their experiences related to the slum development project. We also discuss the Natural House project and its international and educational significance as a means of inculcating sensitivity and interest in nature among engineering students. We propose a pledge for engineers similar to the Hippocratic Oath for medical professionals.

  14. Life cycle assessment of supercharger for automotive use. Small displacement, high charging pressure engine and environmental load; Jidosha tosaiyo supercharger no life cycle assessment (LCA hyoka). Shohaikiryo kokakyu engine no kankyo eno yasashisa

    Energy Technology Data Exchange (ETDEWEB)

    Takabe, S; Sonoya, T; Hara, M [Ishikawajima-Harima Heavy Industries Co. Ltd., Tokyo (Japan)

    1997-10-01

    In resent years environmental conservation requires low fuel consumption and low emission engine. And environmental load of every car life stage (production, using, abolition) is considered. Life Cycle Assessment of supercharging small displacement engine is reported, compared with natural aspirated engine as same maximum torque and maximum power as supercharging engine. 6 refs., 8 figs., 3 tabs.

  15. The application of computer image analysis in life sciences and environmental engineering

    Science.gov (United States)

    Mazur, R.; Lewicki, A.; Przybył, K.; Zaborowicz, M.; Koszela, K.; Boniecki, P.; Mueller, W.; Raba, B.

    2014-04-01

    The main aim of the article was to present research on the application of computer image analysis in Life Science and Environmental Engineering. The authors used different methods of computer image analysis in developing of an innovative biotest in modern biomonitoring of water quality. Created tools were based on live organisms such as bioindicators Lemna minor L. and Hydra vulgaris Pallas as well as computer image analysis method in the assessment of negatives reactions during the exposition of the organisms to selected water toxicants. All of these methods belong to acute toxicity tests and are particularly essential in ecotoxicological assessment of water pollutants. Developed bioassays can be used not only in scientific research but are also applicable in environmental engineering and agriculture in the study of adverse effects on water quality of various compounds used in agriculture and industry.

  16. 1986 environmental monitoring program report for the Idaho National Engineering Laboratory Site

    International Nuclear Information System (INIS)

    Hoff, D.L.; Chew, E.W.; Rope, S.K.

    1987-05-01

    This report presents onsite and offsite data collected in 1986 for the routine environmental monitoring program conducted by the Radiological and Environmental Sciences Laboratory (RESL) of the Department of Energy (DOE) at the Idaho National Engineering Laboratory (INEL) Site. The purpose of this routine program is to monitor radioactive and nonradioactive materials resulting from INEL Site operations which may reach the surrounding offsite environment and population. This report is prepared in accordance with the DOE requirements in draft DOE Order 5484.1 and is not intended to cover the numerous special environmental research programs being conducted at the INEL by RESL and others

  17. Modeling approaches for characterizing and evaluating environmental exposure to engineered nanomaterials in support of risk-based decision making.

    Science.gov (United States)

    Hendren, Christine Ogilvie; Lowry, Michael; Grieger, Khara D; Money, Eric S; Johnston, John M; Wiesner, Mark R; Beaulieu, Stephen M

    2013-02-05

    As the use of engineered nanomaterials becomes more prevalent, the likelihood of unintended exposure to these materials also increases. Given the current scarcity of experimental data regarding fate, transport, and bioavailability, determining potential environmental exposure to these materials requires an in depth analysis of modeling techniques that can be used in both the near- and long-term. Here, we provide a critical review of traditional and emerging exposure modeling approaches to highlight the challenges that scientists and decision-makers face when developing environmental exposure and risk assessments for nanomaterials. We find that accounting for nanospecific properties, overcoming data gaps, realizing model limitations, and handling uncertainty are key to developing informative and reliable environmental exposure and risk assessments for engineered nanomaterials. We find methods suited to recognizing and addressing significant uncertainty to be most appropriate for near-term environmental exposure modeling, given the current state of information and the current insufficiency of established deterministic models to address environmental exposure to engineered nanomaterials.

  18. Effects of Metal Micro and Nano-Particles on hASCs: An In Vitro Model

    OpenAIRE

    Palombella, Silvia; Pirrone, Cristina; Rossi, Federica; Armenia, Ilaria; Cherubino, Mario; Valdatta, Luigi; Raspanti, Mario; Bernardini, Giovanni; Gornati, Rosalba

    2017-01-01

    As the knowledge about the interferences of nanomaterials on human staminal cells are scarce and contradictory, we undertook a comparative multidisciplinary study based on the size effect of zero-valent iron, cobalt, and nickel microparticles (MPs) and nanoparticles (NPs) using human adipose stem cells (hASCs) as a model, and evaluating cytotoxicity, morphology, cellular uptake, and gene expression. Our results suggested that the medium did not influence the cell sensitivity but, surprisingly...

  19. Skill Sets Required for Environmental Engineering and Where They Are Learned

    Science.gov (United States)

    Reed, Kathaleen

    2010-01-01

    The purpose of this study was to investigate the knowledge, skills, abilities and traits environmental engineers need. Two questions were asked: what skills are considered important, and where are they learned? Dreyfus and Dreyfus' novice-to-expert model, which describes a progressive, five-step process of skill development that occurs over time…

  20. Visualization on supercomputing platform level II ASC milestone (3537-1B) results from Sandia.

    Energy Technology Data Exchange (ETDEWEB)

    Geveci, Berk (Kitware, Inc., Clifton Park, NY); Fabian, Nathan; Marion, Patrick (Kitware, Inc., Clifton Park, NY); Moreland, Kenneth D.

    2010-09-01

    This report provides documentation for the completion of the Sandia portion of the ASC Level II Visualization on the platform milestone. This ASC Level II milestone is a joint milestone between Sandia National Laboratories and Los Alamos National Laboratories. This milestone contains functionality required for performing visualization directly on a supercomputing platform, which is necessary for peta-scale visualization. Sandia's contribution concerns in-situ visualization, running a visualization in tandem with a solver. Visualization and analysis of petascale data is limited by several factors which must be addressed as ACES delivers the Cielo platform. Two primary difficulties are: (1) Performance of interactive rendering, which is most computationally intensive portion of the visualization process. For terascale platforms, commodity clusters with graphics processors(GPUs) have been used for interactive rendering. For petascale platforms, visualization and rendering may be able to run efficiently on the supercomputer platform itself. (2) I/O bandwidth, which limits how much information can be written to disk. If we simply analyze the sparse information that is saved to disk we miss the opportunity to analyze the rich information produced every timestep by the simulation. For the first issue, we are pursuing in-situ analysis, in which simulations are coupled directly with analysis libraries at runtime. This milestone will evaluate the visualization and rendering performance of current and next generation supercomputers in contrast to GPU-based visualization clusters, and evaluate the performance of common analysis libraries coupled with the simulation that analyze and write data to disk during a running simulation. This milestone will explore, evaluate and advance the maturity level of these technologies and their applicability to problems of interest to the ASC program. Scientific simulation on parallel supercomputers is traditionally performed in four

  1. Detecting and Characterizing Engineered Nanomaterials: A Key Tool for Environmentally Responsible Nanotechnology

    Science.gov (United States)

    The same properties of engineered nanomaterials (ENMs) that are the basis for their many novel applications also raise important issues related to their environmental impact. ENMs might not behave similarly in the environment to the dissolved or solid forms of the chemicals from ...

  2. The role of karst in engineering and environmental geosciences

    Directory of Open Access Journals (Sweden)

    H. C. Ho

    2011-08-01

    Full Text Available Karst is a unique landform developed by soluble rock. It usually relates to the groundwater drainage system, and provides important water resources. Current researches indicate that karst is closely related to the Earth system and environmental protection, and it can also create potential natural hazards such as sinkhole flooding and land subsidence in urban area. Its relationship with hydrogeology has also been an important factor for studying water pollution and nutrient cycles in engineering geosciences and agricultural geology.

  3. Genetic diversity of internalin genes in the ascB-dapE locus among Listeria monocytogenes lineages III and IV strains.

    Science.gov (United States)

    Chen, Jianshun; Cheng, Changyong; Lv, Yonghui; Fang, Weihuan

    2013-09-01

    Listeria monocytogenes is an important foodborne pathogen encompassing four phylogenetic lineages. Lineages III and IV are rare, but have been reported to show considerable biodiversity, providing important clues for the evolutionary history in Listeria. In this study, analysis of the ascB-dapE locus reveals genetic diversity in lineages III and IV, and is consistent with the classification of sublineages. Four of the six genetic patterns (two of sublineage IIIC and two of lineage IV) are specific to these two lineages. The ascB-dapE locus suggests a hot spot for genome diversification, and serves as an attractive molecular marker for better understanding of the biodiversity and population structure of lineages III and IV strains. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.

    Science.gov (United States)

    Wu, Qiong; Liu, Ming-Chao; Yang, Jun; Wang, Jiu-Feng; Zhu, Yao-Hong

    2016-02-15

    Escherichia coli is a major environmental pathogen causing bovine mastitis, which leads to mammary tissue damage and cell death. We explored the effects of the probiotic Lactobacillus rhamnosus GR-1 on ameliorating E. coli-induced inflammation and cell damage in primary bovine mammary epithelial cells (BMECs). Increased Toll-like receptor 4 (TLR4), NOD1, and NOD2 mRNA expression was observed following E. coli challenge, but this increase was attenuated by L. rhamnosus GR-1 pretreatment. Immunofluorescence and Western blot analyses revealed that L. rhamnosus GR-1 pretreatment decreased the E. coli-induced increases in the expression of the NOD-like receptor family member pyrin domain-containing protein 3 (NLRP3) and the serine protease caspase 1. However, expression of the adaptor protein apoptosis-associated speck-like protein (ASC, encoded by the Pycard gene) was decreased during E. coli infection, even with L. rhamnosus GR-1 pretreatment. Pretreatment with L. rhamnosus GR-1 counteracted the E. coli-induced increases in interleukin-1β (IL-1β), -6, -8, and -18 and tumor necrosis factor alpha mRNA expression but upregulated IL-10 mRNA expression. Our data indicate that L. rhamnosus GR-1 reduces the adhesion of E. coli to BMECs, subsequently ameliorating E. coli-induced disruption of cellular morphology and ultrastructure and limiting detrimental inflammatory responses, partly via promoting TLR2 and NOD1 synergism and attenuating ASC-independent NLRP3 inflammasome activation. Although the residual pathogenic activity of L. rhamnosus, the dosage regimen, and the means of probiotic supplementation in cattle remain undefined, our data enhance our understanding of the mechanism of action of this candidate probiotic, allowing for development of specific probiotic-based therapies and strategies for preventing pathogenic infection of the bovine mammary gland. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  5. An Alternative Optimization Model and Robust Experimental Design for the Assignment Scheduling Capability for Unmanned Aerial Vehicles (ASC-U) Simulation

    National Research Council Canada - National Science Library

    Oliver, Derek M

    2007-01-01

    .... TRAC selected ASC-U to provide insight into the programmatic decisions addressed in the U.S. Army UAV-Mix Analysis that directly affects future development and fielding of UAVs to include the Future Combat System...

  6. Report for Working Group 1: Design Research in Civil and Environmental Engineering

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn; Paradisi, Irene

    2013-01-01

    The first 2013 DCEE working group meeting focused on issues associated with design research in civil and environmental engineering. It addressed some of the motivation for establishing design as a research discipline in CEE and some of the challenges and outstanding questions about how to do so....

  7. Quantificação de compostos fenólicos e ácido ascórbico em frutos e polpas congeladas de acerola, caju, goiaba e morango

    Directory of Open Access Journals (Sweden)

    Juliana Mesquita Freire

    2013-12-01

    Full Text Available O crescente interesse da população pela promoção da saúde vem despertando a atenção dos consumidores por alimentos ricos em antioxidantes, combinado com a praticidade do consumo de sucos de frutos processados. O presente trabalho objetivou quantificar e avaliar a capacidade antioxidante de compostos fenólicos e ácido ascórbico em frutas in natura e polpas congeladas. As frutas in natura e polpas congeladas obtidas na região de Lavras - MG foram submetidas à quantificação de compostos fenólicos e ácido ascórbico e os respectivos extratos acetônico-etanólico e acetônico-metanólico. Foram determinadas suas atividades antioxidantes pelos métodos radicalares DPPH e ABTS. O extrato acetônico-metanólico foi mais efetivo para extrair os compostos antioxidantes das amostras. Apenas as polpas congeladas de acerola apresentaram uma redução do teor de compostos fenólicos em relação ao fruto. Para o teor de ácido ascórbico, houve uma redução nas polpas congeladas de acerola e goiaba. As amostras de acerola apresentaram os maiores teores de compostos fenólicos, ácido ascórbico e atividade antioxidante em relação aos demais frutos analisados.

  8. EXTENSION OF COMPUTER-AIDED PROCESS ENGINEERING APPLICATIONS TO ENVIRONMENTAL LIFE CYCLE ASSESSMENT AND SUPPLY CHAIN MANAGEMENT

    Science.gov (United States)

    The potential of computer-aided process engineering (CAPE) tools to enable process engineers to improve the environmental performance of both their processes and across the life cycle (from cradle-to-grave) has long been proffered. However, this use of CAPE has not been fully ach...

  9. The influence of environmental factors on bone tissue engineering.

    Science.gov (United States)

    Szpalski, Caroline; Sagebin, Fabio; Barbaro, Marissa; Warren, Stephen M

    2013-05-01

    Bone repair and regeneration are dynamic processes that involve a complex interplay between the substrate, local and systemic cells, and the milieu. Although each constituent plays an integral role in faithfully recreating the skeleton, investigators have long focused their efforts on scaffold materials and design, cytokine and hormone administration, and cell-based therapies. Only recently have the intangible aspects of the milieu received their due attention. In this review, we highlight the important influence of environmental factors on bone tissue engineering. Copyright © 2012 Wiley Periodicals, Inc.

  10. Environmental assessment for Breeder Reprocessing Engineering Test (BRET): Revision 1

    International Nuclear Information System (INIS)

    Lerch, R.E.

    1989-03-01

    This Environmental Assessment (EA) is for the proposed installation and operation of an integrated breeder fuel reprocessing test system in the shielded cells of the Fuels and Materials Examination Facility (FMEF) at Hanford and the associated modifications to the FMEF to accommodate BRET. These modifications would begin in FY-1986 subject to Congressional authorization. Hot operations would be scheduled to start in the early 1990's. The system, called the Breeder Reprocessing Engineering Test (BRET), is being designed to provide a test capability for developing the demonstrating fuel reprocessing, remote maintenance, and safeguards technologies for breeder reactor fuels. This EA describes (1) the action being proposed, (2) the existing environment which would be affected, (3) the potential environmental impacts from normal operations and severe accidents from the proposed action, (4) potential conflicts with federal, state, regional, and/or local plans for the area, and (5) environmental implications of alternatives considered to the proposed action. 41 refs., 10 figs., 31 tabs

  11. The Environmental Compliance Office at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Cooper, S.C.

    1990-01-01

    The Idaho Operations Office of the U.S. Department of Energy (DOE-ID) has established an Environmental Compliance Office (ECO) at the Idaho National Engineering Laboratory (INEL). This office has been formed to ensure that INEL operations and activities are in compliance with all applicable environmental state and federal regulations. The ECO is headed by a DOE-ID manager and consists of several teams, each of which is led by a DOE-ID employee with members from DOE-ID, from INEL government contractors, and from DOE-ID consultants. The teams are (a) the negotiated compliance team, (b) the compliance implementation team (CIT), (c) the permits team, (d) the interagency agreement (IAG) team, (e) the consent order and compliance agreement (COCA) oversight team, and (f) the National Environmental Policy Act (NEPA) team. The last two teams were short term and have already completed their respective assignments. The functions of the teams and the results obtained by each are discussed

  12. In summary: Idaho National Engineering and Environmental Laboratory site environmental report for calendar year 1997

    International Nuclear Information System (INIS)

    Mitchell, R.G.; Roush, D.E. Jr.; Evans, R.B.

    1998-10-01

    Every human is exposed to natural radiation. This exposure comes from many sources, including cosmic radiation from outer space, naturally-occurring radon, and radioactivity from substances in the body. In addition to natural sources of radiation, humans can also be exposed to human-generated sources of radiation. Some examples of these sources include nuclear medicine, X-rays, nuclear weapons testing, and accidents at nuclear power plants. The Idaho National Engineering and Environmental Laboratory (INEEL) is a US Department of Energy (DOE) research facility that deals, in part, with studying nuclear reactors and the storage and cleanup of radioactive materials. Careful handling and rigorous procedures do not completely eliminate the risk of releasing radioactivity. So, there is a possibility for a member of the public near the INEEL to be exposed to radioactivity from the INEEL. Extensive monitoring of the environment takes place one and around the INEEL. These programs search for radionuclides and other contaminants. The results of these programs are presented each year in a site environmental report. This document summarizes the INEEL site environmental report for 1997

  13. Virtual Placements to Develop Employability Skills for Civil and Environmental Engineering Students

    Science.gov (United States)

    Paul, Parneet

    2015-01-01

    This project work addresses the crucial need to encourage undergraduate civil and environmental engineering students to gain employment skills and training right from the start of their studies so that their overall employability increases; their confidence level in networking with industry and within the workplace increases; and so that they are…

  14. Cytocompatible in situ forming chitosan/hyaluronan hydrogels via a metal-free click chemistry for soft tissue engineering.

    Science.gov (United States)

    Fan, Ming; Ma, Ye; Mao, Jiahui; Zhang, Ziwei; Tan, Huaping

    2015-07-01

    Injectable hydrogels are important cell scaffolding materials for tissue engineering and regenerative medicine. Here, we report a new class of biocompatible and biodegradable polysaccharide hydrogels derived from chitosan and hyaluronan via a metal-free click chemistry, without the addition of copper catalyst. For the metal-free click reaction, chitosan and hyaluronan were modified with oxanorbornadiene (OB) and 11-azido-3,6,9-trioxaundecan-1-amine (AA), respectively. The gelation is attributed to the triazole ring formation between OB and azido groups of polysaccharide derivatives. The molecular structures were verified by FT-IR spectroscopy and elemental analysis, giving substitution degrees of 58% and 47% for chitosan-OB and hyaluronan-AA, respectively. The in vitro gelation, morphologies, equilibrium swelling, compressive modulus and degradation of the composite hydrogels were examined. The potential of the metal-free hydrogel as a cell scaffold was demonstrated by encapsulation of human adipose-derived stem cells (ASCs) within the gel matrix in vitro. Cell culture showed that this metal-free hydrogel could support survival and proliferation of ASCs. A preliminary in vivo study demonstrated the usefulness of the hydrogel as an injectable scaffold for adipose tissue engineering. These characteristics provide a potential opportunity to use the metal-free click chemistry in preparation of biocompatible hydrogels for soft tissue engineering applications. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  15. TLD environmental monitoring at the Institute of Nuclear Engineering in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Taam, I.H. [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Caixa Postal 68550, 21945-970 Rio de Janeiro, RJ (Brazil); Rosa, L.A.R. da [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Av. Salvador Allende s/n, Caixa Postal 37760, 22780-160 Rio de Janeiro, RJ (Brazil)], E-mail: lrosa@ird.gov.br; Crispim, V.R. [PEN/COPPE-DNC/POLI/CT/UFRJ, Caixa Postal 68509, 21941-972 Rio de Janeiro, RJ (Brazil)

    2008-09-15

    Since 2003 the Institute of Nuclear Engineering in Rio de Janeiro city, Brazil, operates a new cyclotron, RDS-111, to produce {sup 18}F-Fluorodeoxyglucose to be used in nuclear medicine. Additionally, the IEN radioactive waste repository has been enlarged during the past last years, receiving a considerable amount of radioactive materials. Therefore, it became necessary to evaluate a possible increase of the environmental gamma exposure rates at the institute site due to the operation of the new accelerator and the enlargement of the institute waste repository as well. LiF:Mg,Cu,P, TLD-100H, and TL detectors were employed for environmental kerma rate evaluation and the results were compared with previous results obtained before the RDS-111 operation initialisation and the enlargement of IEN waste repository. No significant contribution for the enhancement of environmental gamma kerma rates was detected.

  16. Mechanical Engineering | Classification | College of Engineering & Applied

    Science.gov (United States)

    Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on Energy Doctoral Programs in Engineering Non-Degree Candidate Departments Biomedical Engineering Biomedical Engineering Industry Advisory Council Civil & Environmental Engineering Civil &

  17. Biomedical Engineering | Classification | College of Engineering & Applied

    Science.gov (United States)

    Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on Energy Doctoral Programs in Engineering Non-Degree Candidate Departments Biomedical Engineering Biomedical Engineering Industry Advisory Council Civil & Environmental Engineering Civil &

  18. Electrical Engineering | Classification | College of Engineering & Applied

    Science.gov (United States)

    Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on Energy Doctoral Programs in Engineering Non-Degree Candidate Departments Biomedical Engineering Biomedical Engineering Industry Advisory Council Civil & Environmental Engineering Civil &

  19. Genetic and physical analysis of a YAC contig spanning the fungal disease resistance locus Asc of tomato (Lycopersicon esculentum)

    NARCIS (Netherlands)

    Mesbah, L.A.; Kneppers, T.J.A.; Takken, F.L.W.; Laurent, P.; Hille, J.; Nijkamp, H.J.J.

    1998-01-01

    The Alternaria stem canker disease of tomato is caused by the necrotrophic fungal pathogen Alternaria alternata f. sp. lycopersici (AAL). The fungus produces AAL toxins that kill the plant tissue. Resistance to the fungus segregates as a single locus, called Asc, and has been genetically mapped on

  20. Genetic and physical analysis of a YAC contig spannig the fungal disease resistance locus Asc of tomato (Lycopersicon esculentum)

    NARCIS (Netherlands)

    Mesbah, L.A.; Kneppers, T.J.A.; Takken, F.L.W.; Laurent, P.J.F.; Hille, J.; Nijkamp, H.J.J.

    1999-01-01

    The Alternaria in stem canker disease of tomato is caused by the necrotrophic fungal pathogen Alternaria alternata f. sp. lycopersici (AAL). The fungus produces AAL toxins that kill the plant tissue. Resistance to the fungus segregates as a single locus, called Asc, and has been genetically mapped

  1. Materials Science & Engineering | Classification | College of Engineering &

    Science.gov (United States)

    Biomedical Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on Energy Doctoral Programs in Engineering Non-Degree Candidate Departments Biomedical Engineering Biomedical Engineering Industry Advisory Council Civil & Environmental Engineering Civil &

  2. 2003 Wastewater Land Application Site Performance Reports for the Idaho National Engineering and Environmental Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Teresa R. Meachum

    2004-02-01

    The 2003 Wastewater Land Application Site Performance Reports for the Idaho National Engineering and Environmental Laboratory describe the conditions for the facilities with State of Idaho Wastewater Land Application Permits. Permit-required monitoring data are summarized, and permit exceedences or environmental impacts relating to the operations of the facilities during the 2003 permit year are discussed.

  3. Engineering the Surface/Interface Structures of Titanium Dioxide Micro and Nano Architectures towards Environmental and Electrochemical Applications

    DEFF Research Database (Denmark)

    Wang, Xiaoliang; Zhao, Yanyan; Mølhave, Kristian

    2017-01-01

    advances in the surface and interface engineering and applications in environmental and electrochemical applications. We analyze the advantages of surface/interface engineered TiO₂ micro and nano structures, and present the principles and growth mechanisms of TiO₂ nanostructures via different strategies...

  4. The Role of Alternative Testing Strategies in Environmental Risk Assessment of Engineered Nanomaterials

    DEFF Research Database (Denmark)

    Hjorth, Rune; Holden, Patricia; Hansen, Steffen Foss

    2017-01-01

    ) workshop in Washington, D.C. and serves as the point of depature for this paper. Here we present the main outcomes by describing and defining the use of ATS for ENMs as well as discussing its future role in environmental risk science. We conclude that diversity in testing should be encouraged to avoid...... chemicals are challenged. Nonetheless, standardized whole organism animal testing is still considered the gold standard for environmental risk assessment. Advancing risk analysis of engineered nanomaterials (ENMs) through ATS was discussed in September 2014 at an international Society for Risk Analysis (SRA...... be utilized to skip uncertain environmental extrapolations and give rise to more accurate risk analysis....

  5. 78 FR 37533 - Notice of Intent To Prepare a Programmatic Environmental Impact Statement for Engineered High...

    Science.gov (United States)

    2013-06-21

    ... that occur in nature without human intervention), and specifically engineered to produce more energy... Environmental Policy Act (NEPA) of 1969 (42 U.S.C. 4321 et seq.) requirements, the Council on Environmental... promoting U.S. energy security by providing reliable, clean, and affordable energy and strengthening U.S...

  6. Advanced Stirling Convertor Development for NASA Radioisotope Power Systems

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Scott D.; Collins, Josh

    2015-01-01

    Sunpower Inc.'s Advanced Stirling Convertor (ASC) initiated development under contract to the NASA Glenn Research Center and after a series of successful demonstrations, the ASC began transitioning from a technology development project to a flight development project. The ASC has very high power conversion efficiency making it attractive for future Radioisotope Power Systems (RPS) in order to make best use of the low plutonium-238 fuel inventory in the United States. In recent years, the ASC became part of the NASA and Department of Energy (DOE) Advanced Stirling Radioisotope Generator (ASRG) Integrated Project. Sunpower held two parallel contracts to produce ASCs, one with the DOE and Lockheed Martin to produce the ASC-F flight convertors, and one with NASA Glenn for the production of ASC-E3 engineering units, the initial units of which served as production pathfinders. The integrated ASC technical team successfully overcame various technical challenges that led to the completion and delivery of the first two pairs of flightlike ASC-E3 by 2013. However, in late fall 2013, the DOE initiated termination of the Lockheed Martin ASRG flight development contract driven primarily by budget constraints. NASA continues to recognize the importance of high-efficiency ASC power conversion for RPS and continues investment in the technology including the continuation of ASC-E3 production at Sunpower and the assembly of the ASRG Engineering Unit #2. This paper provides a summary of ASC technical accomplishments, overview of tests at Glenn, plans for continued ASC production at Sunpower, and status of Stirling technology development.

  7. Evaluation of environmental filtration control of engineered nanoparticles using the Harvard Versatile Engineered Nanomaterial Generation System (VENGES)

    Science.gov (United States)

    Echevarría-Vega, Manuel E.; Sotiriou, Georgios A.; Santeufemio, Christopher; Schmidt, Daniel; Demokritou, Philip; Ellenbecker, Michael

    2013-01-01

    Applying engineering controls to airborne engineered nanoparticles (ENPs) is critical to prevent environmental releases and worker exposure. This study evaluated the effectiveness of two air sampling and six air cleaning fabric filters at collecting ENPs using industrially relevant flame-made engineered nanoparticles generated using a versatile engineered nanomaterial generation system (VENGES), recently designed and constructed at Harvard University. VENGES has the ability to generate metal and metal oxide exposure atmospheres while controlling important particle properties such as primary particle size, aerosol size distribution, and agglomeration state. For this study, amorphous SiO2 ENPs with a 15.4 nm primary particle size were generated and diluted with HEPA-filtered air. The aerosol was passed through the filter samples at two different filtration face velocities (2.3 and 3.5 m/min). Particle concentrations as a function of particle size were measured upstream and downstream of the filters using a specially designed filter test system to evaluate filtration efficiency. Real time instruments (FMPS and APS) were used to measure particle concentration for diameters from 5 to 20,000 nm. Membrane-coated fabric filters were found to have enhanced nanoparticle collection efficiency by 20–46 % points compared to non-coated fabric and could provide collection efficiency above 95 %. PMID:23412707

  8. Evaluation of environmental filtration control of engineered nanoparticles using the Harvard Versatile Engineered Nanomaterial Generation System (VENGES)

    International Nuclear Information System (INIS)

    Tsai, Candace S.-J.; Echevarría-Vega, Manuel E.; Sotiriou, Georgios A.; Santeufemio, Christopher; Schmidt, Daniel; Demokritou, Philip; Ellenbecker, Michael

    2012-01-01

    Applying engineering controls to airborne engineered nanoparticles (ENPs) is critical to prevent environmental releases and worker exposure. This study evaluated the effectiveness of two air sampling and six air cleaning fabric filters at collecting ENPs using industrially relevant flame-made engineered nanoparticles generated using a versatile engineered nanomaterial generation system (VENGES), recently designed and constructed at Harvard University. VENGES has the ability to generate metal and metal oxide exposure atmospheres while controlling important particle properties such as primary particle size, aerosol size distribution, and agglomeration state. For this study, amorphous SiO 2 ENPs with a 15.4 nm primary particle size were generated and diluted with HEPA-filtered air. The aerosol was passed through the filter samples at two different filtration face velocities (2.3 and 3.5 m/min). Particle concentrations as a function of particle size were measured upstream and downstream of the filters using a specially designed filter test system to evaluate filtration efficiency. Real time instruments (FMPS and APS) were used to measure particle concentration for diameters from 5 to 20,000 nm. Membrane-coated fabric filters were found to have enhanced nanoparticle collection efficiency by 20–46 % points compared to non-coated fabric and could provide collection efficiency above 95%.

  9. Network protocol changes can improve DisCom WAN performance : evaluating TCP modifications and SCTP in the ASC tri-lab environment.

    Energy Technology Data Exchange (ETDEWEB)

    Tolendino, Lawrence F.; Hu, Tan Chang

    2005-06-01

    The Advanced Simulation and Computing (ASC) Distance Computing (DisCom) Wide Area Network (WAN) is a high performance, long distance network environment that is based on the ubiquitous TCP/IP protocol set. However, the Transmission Control Protocol (TCP) and the algorithms that govern its operation were defined almost two decades ago for a network environment vastly different from the DisCom WAN. In this paper we explore and evaluate possible modifications to TCP that purport to improve TCP performance in environments like the DisCom WAN. We also examine a much newer protocol, SCTP (Stream Control Transmission Protocol) that claims to provide reliable network transport while also implementing multi-streaming, multi-homing capabilities that are appealing in the DisCom high performance network environment. We provide performance comparisons and recommendations for continued development that will lead to network communications protocol implementations capable of supporting the coming ASC Petaflop computing environments.

  10. First environmental data from the EUV engineering test stand

    Science.gov (United States)

    Klebanoff, Leonard E.; Malinowski, Michael E.; Grunow, Philip A.; Clift, W. Miles; Steinhaus, Chip; Leung, Alvin H.; Haney, Steven J.

    2001-08-01

    The first environmental data from the Engineering Test Stand (ETS) has been collected. Excellent control of high-mass hydrocarbons has been observed. This control is a result of extensive outgas testing of components and materials, vacuum compatible design of the ETS, careful cleaning of parts and pre-baking of cables and sub assemblies where possible, and clean assembly procedures. As a result of the hydrocarbon control, the residual ETS vacuum environment is rich in water vapor. Analysis of witness plate data indicates that the ETS environment does not pose a contamination risk to the optics in the absence of EUV irradiation. However, with EUV exposure, the water rich environment can lead to EUV- induced water oxidation of the Si-terminated Mo/Si optics. Added ethanol can prevent optic oxidation, allowing carbon growth via EUV cracking of low-level residual hydrocarbons to occur. The EUV environmental issues are understood, mitigation approaches have been validated, and EUV optic contamination appears to be manageable.

  11. Simulated environmental risk estimation of engineered nanomaterials: a case of cosmetics in Johannesburg City

    CSIR Research Space (South Africa)

    Musee, N

    2011-09-01

    Full Text Available This paper attempts to quantify the potential risks posed by engineered nanomaterials (ENMs) to the aquatic and terrestrial ecosystems from cosmetic-based nanoproducts. The predicted environmental concentrations (PEC) were modelled for the silver (n...

  12. Environmental Science and Engineering Merit Badges: An Exploratory Case Study of a Non-Formal Science Education Program and the U.S. Scientific and Engineering Practices

    Science.gov (United States)

    Vick, Matthew E.; Garvey, Michael P.

    2016-01-01

    The Boy Scouts of America's Environmental Science and Engineering merit badges are two of their over 120 merit badges offered as a part of a non-formal educational program to U.S. boys. The Scientific and Engineering Practices of the U.S. Next Generation Science Standards provide a vision of science education that includes integrating eight…

  13. A national environmental/energy workforce assessment. Post-secondary education profile: composite i (environmental engineering/health). Final report on phase 2

    International Nuclear Information System (INIS)

    1978-12-01

    This study is one of 16 volumes aggregating data on representative environmental education offerings in the United States at post-secondary education institutions and in the private sector of the economy. Structured around on-site interviews, the study describes the institutions' education programs--their program structure, representative course offerings, faculty structure, and program requirements. In addition, the study provides information on the employment history of graduates. Designed as Phase II of a three-phase program, the study presents the information on schools with emphasis on environmental engineering/health. The study is an overview. It doesn't include all environmental programs in the United States, and it makes no attempt to evaluate the program offerings

  14. Isolation and expansion of adipose-derived stem cells for tissue engineering

    DEFF Research Database (Denmark)

    Fink, Trine; Rasmussen, Jeppe Grøndahl; Lund, Pia

    2011-01-01

    For treatment of cardiac failure with bone marrow-derived mesenchymal stem cells, several clinical trials are ongoing. However, more attention is gathering on the use of adipose tissue-derived stem cells (ASCs). This paper describes the optimization of isolation and propagation of ASCs for subseq......For treatment of cardiac failure with bone marrow-derived mesenchymal stem cells, several clinical trials are ongoing. However, more attention is gathering on the use of adipose tissue-derived stem cells (ASCs). This paper describes the optimization of isolation and propagation of ASCs...

  15. 2016 Milwaukee Engineering Research Conference | College of Engineering &

    Science.gov (United States)

    Biomedical Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on Energy Doctoral Programs in Engineering Non-Degree Candidate Departments Biomedical Engineering Biomedical Engineering Industry Advisory Council Civil & Environmental Engineering Civil &

  16. Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials

    Science.gov (United States)

    Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant ...

  17. High-resolution global grids of revised Priestley-Taylor and Hargreaves-Samani coefficients for assessing ASCE-standardized reference crop evapotranspiration and solar radiation

    Science.gov (United States)

    Aschonitis, Vassilis G.; Papamichail, Dimitris; Demertzi, Kleoniki; Colombani, Nicolo; Mastrocicco, Micol; Ghirardini, Andrea; Castaldelli, Giuseppe; Fano, Elisa-Anna

    2017-08-01

    The objective of the study is to provide global grids (0.5°) of revised annual coefficients for the Priestley-Taylor (P-T) and Hargreaves-Samani (H-S) evapotranspiration methods after calibration based on the ASCE (American Society of Civil Engineers)-standardized Penman-Monteith method (the ASCE method includes two reference crops: short-clipped grass and tall alfalfa). The analysis also includes the development of a global grid of revised annual coefficients for solar radiation (Rs) estimations using the respective Rs formula of H-S. The analysis was based on global gridded climatic data of the period 1950-2000. The method for deriving annual coefficients of the P-T and H-S methods was based on partial weighted averages (PWAs) of their mean monthly values. This method estimates the annual values considering the amplitude of the parameter under investigation (ETo and Rs) giving more weight to the monthly coefficients of the months with higher ETo values (or Rs values for the case of the H-S radiation formula). The method also eliminates the effect of unreasonably high or low monthly coefficients that may occur during periods where ETo and Rs fall below a specific threshold. The new coefficients were validated based on data from 140 stations located in various climatic zones of the USA and Australia with expanded observations up to 2016. The validation procedure for ETo estimations of the short reference crop showed that the P-T and H-S methods with the new revised coefficients outperformed the standard methods reducing the estimated root mean square error (RMSE) in ETo values by 40 and 25 %, respectively. The estimations of Rs using the H-S formula with revised coefficients reduced the RMSE by 28 % in comparison to the standard H-S formula. Finally, a raster database was built consisting of (a) global maps for the mean monthly ETo values estimated by ASCE-standardized method for both reference crops, (b) global maps for the revised annual coefficients of the P

  18. ASCE application guide for recommended practice for fiber-reinforced polymer products for overhead utility line structures

    Energy Technology Data Exchange (ETDEWEB)

    Gnandt, E. [T and D High Voltage Consulting, Vancouver, BC (Canada)

    2002-07-01

    The participants to the American Society of Civil Engineers (ASCE) prepared an application guide to provide guidelines to utilities and manufacturers on topics ranging from design to manufacture, testing and installation of fiber-reinforced polymer (FRP) products. The intent was also to help utilities with a possible replacement material for wood, steel and pre-stressed concrete. FRP products are constructed from fiber and resin and offer several advantages such as light weight and high strength-to-weight ratio, low maintenance, dimensional stability, resistance to rot, corrosion, chemicals and pest damage. FRP products can be used for lighting poles, ladders and grating, transformer pads, pole line hardware and crossarms, and other applications. There are five structural configurations: (1) cantilevered structures (single pole), (2) guyed structures, framed structures (H-Frame), (4) a combination of (1), (2), and (3), and (5) lattice structures (transmission class). The author listed some of the initial considerations: physical characteristics, guying and grounding, deflection and load testing, attached items, and durability to name only a few. The materials and manufacturing processes were briefly explained, namely the pultrusion method, the filament winding method, and the centrifugal casting method. Design loads considerations are discussed, as are performance-based criteria such as mechanical, coating durability and electrical. Quality control, assembly erection and storage, and in-service considerations are also discussed. The author concluded the presentation with a section dealing with field inspections. figs.

  19. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement

    International Nuclear Information System (INIS)

    1994-06-01

    This document analyzes at a programmatic level the potential environmental consequences over the next 40 years of alternatives related to the transportation, receipt, processing, and storage of spent nuclear fuel under the responsibility of the US Department of Energy. It also analyzes the site-specific consequences of the Idaho National Engineering Laboratory sitewide actions anticipated over the next 10 years for waste and spent nuclear fuel management and environmental restoration. For programmatic spent nuclear fuel management this document analyzes alternatives of no action, decentralization, regionalization, centralization and the use of the plans that existed in 1992/1993 for the management of these materials. For the Idaho National Engineering Laboratory, this document analyzes alternatives of no action, ten-year plan, minimum and maximum and maximum treatment, storage, and disposal of US Department of Energy wastes

  20. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement

    International Nuclear Information System (INIS)

    1994-06-01

    This document analyzes at a pregrammatic level the potential environmental consequences over the next 40 years of alternatives related to the transportation, receipt, processing, and storage of spent nuclear fuel under the responsibility of the US Department of Energy. It also analyzes the site-specific consequences of the Idaho National Engineering Laboratory sitewide actions anticipated over the next 10 years for waste and spent nuclear fuel management and environmental restoration. For pregrammatic spent nuclear fuel management, this document analyzes alternatives of no action, decentralization, regionalization, centralization and the use of the plans that existed in 1992/1993 for the management of these materials. For the Idaho National Engineering Laboratory, this document analyzes alternatives of no action, ten-year plan, minimum and maximum treatment, storage, and disposal of US Department of Energy wastes

  1. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs draft environmental impact statement

    International Nuclear Information System (INIS)

    1994-06-01

    This document analyzes at a programmatic level the potential environmental consequences over the next 40 years of alternatives related to the transportation, receipt, processing, and storage of spent nuclear fuel under the responsibility of the US Department of Energy. It also analyzes the site-specific consequences of the Idaho National Engineering Laboratory sitewide actions anticipated over the next 10 years for waste and spent nuclear fuel management and environmental restoration. For programmatic spent nuclear fuel management, this document analyzes alternatives of no action, decentralization, regionalization, centralization and the use of the plans that existed in 1992/1993 for the management of these materials. For the Idaho National Engineering Laboratory, this document analyzes alternatives of no action, ten-year plan, minimum and maximum treatment, storage, and disposal of US Department of Energy wastes

  2. Methylcellulose Based Thermally Reversible Hydrogel System for Tissue Engineering Applications

    Directory of Open Access Journals (Sweden)

    Ram V. Devireddy

    2013-06-01

    Full Text Available The thermoresponsive behavior of a Methylcellulose (MC polymer was systematically investigated to determine its usability in constructing MC based hydrogel systems in cell sheet engineering applications. Solution-gel analyses were made to study the effects of polymer concentration, molecular weight and dissolved salts on the gelation of three commercially available MCs using differential scanning calorimeter and rheology. For investigation of the hydrogel stability and fluid uptake capacity, swelling and degradation experiments were performed with the hydrogel system exposed to cell culture solutions at incubation temperature for several days. From these experiments, the optimal composition of MC-water-salt that was able to produce stable hydrogels at or above 32 °C, was found to be 12% to 16% of MC (Mol. wt. of 15,000 in water with 0.5× PBS (~150mOsm. This stable hydrogel system was then evaluated for a week for its efficacy to support the adhesion and growth of specific cells in culture; in our case the stromal/stem cells derived from human adipose tissue derived stem cells (ASCs. The results indicated that the addition (evenly spread of ~200 µL of 2 mg/mL bovine collagen type -I (pH adjusted to 7.5 over the MC hydrogel surface at 37 °C is required to improve the ASC adhesion and proliferation. Upon confluence, a continuous monolayer ASC sheet was formed on the surface of the hydrogel system and an intact cell sheet with preserved cell–cell and cell–extracellular matrix was spontaneously and gradually detached when the grown cell sheet was removed from the incubator and exposed to room temperature (~30 °C within minutes.

  3. Methylcellulose based thermally reversible hydrogel system for tissue engineering applications.

    Science.gov (United States)

    Thirumala, Sreedhar; Gimble, Jeffrey M; Devireddy, Ram V

    2013-06-25

    The thermoresponsive behavior of a Methylcellulose (MC) polymer was systematically investigated to determine its usability in constructing MC based hydrogel systems in cell sheet engineering applications. Solution-gel analyses were made to study the effects of polymer concentration, molecular weight and dissolved salts on the gelation of three commercially available MCs using differential scanning calorimeter and rheology. For investigation of the hydrogel stability and fluid uptake capacity, swelling and degradation experiments were performed with the hydrogel system exposed to cell culture solutions at incubation temperature for several days. From these experiments, the optimal composition of MC-water-salt that was able to produce stable hydrogels at or above 32 °C, was found to be 12% to 16% of MC (Mol. wt. of 15,000) in water with 0.5× PBS (~150mOsm). This stable hydrogel system was then evaluated for a week for its efficacy to support the adhesion and growth of specific cells in culture; in our case the stromal/stem cells derived from human adipose tissue derived stem cells (ASCs). The results indicated that the addition (evenly spread) of ~200 µL of 2 mg/mL bovine collagen type -I (pH adjusted to 7.5) over the MC hydrogel surface at 37 °C is required to improve the ASC adhesion and proliferation. Upon confluence, a continuous monolayer ASC sheet was formed on the surface of the hydrogel system and an intact cell sheet with preserved cell-cell and cell-extracellular matrix was spontaneously and gradually detached when the grown cell sheet was removed from the incubator and exposed to room temperature (~30 °C) within minutes.

  4. Engineering for Sustainable Development - an Obligatory Skill of the Future Engineer

    DEFF Research Database (Denmark)

    Alting, Leo

    2001-01-01

    , the environmental and the social/societal. The economical responsibility is handled by the well-known and accepted methods/tools/regulations, to handle the environmental responsibility good engineering methods and tools are appearing, but to handle the social/societal responsibility only fragmented and inconsistent...... elements exist. However, one thing is clear - we will have to provide our engineering students with understanding, methods and tools so that they can engineer sustainable solutions - especially engineer environmentally friendlier solutions. The Department of Manufacturing Engineering and the Institute...... for Product Development have actively taken part in the development from awareness of the environmental problems to providing methods and tools to support a sustainable development. The situation today in the education at DTU is shortly mentioned and the education at the Department of Manufacturing...

  5. Pangasius in the EU market; Prospects for the position of (ASC-certified) pangasius in the EU retail and food service sector

    NARCIS (Netherlands)

    Beukers, R.; Pijl, van der W.; Duijn, van A.P.

    2014-01-01

    The objective of this market study is to investigate the potential short- and long-term benefits for investors to invest in the production of pangasius with a trademark based on ASC certification, for the retail and food service market segments in the EU market.

  6. Using stated preferences to estimate the environmental benefits of using biodiesel fuel in diesel engines

    OpenAIRE

    Jeanty, Pierre Wilner; Hitzhusen, Frederick J.

    2007-01-01

    Using biodiesel fuel to reduce emissions from diesel engines is an area of increasing interest. Many environmental benefits associated with biodiesel are not traded in markets and their estimation requires economic valuation methods applied to non-market goods and services. This paper presents the results of a contingent valuation survey conducted in 2006 in two Ohio regions to estimate willingness to pay for air pollution reduction arising from using biodiesel fuel in diesel engines. The dou...

  7. Environmental monitoring for EG and G Idaho facilities at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Tkachyk, J.W.; Wright, K.C.; Wilhelmsen, R.N.

    1990-08-01

    This report describes the 1989 environmental-monitoring activities of the Environmental Monitoring Unit of EG ampersand G Idaho, Inc., at EG ampersand G-operated facilities at the Idaho National Engineering Laboratory (INEL). The major facilities monitored include the Radioactive Waste Management Complex, the Waste Experimental Reduction Facility, the Mixed Waste Storage Facility, and two surplus facilities. Additional monitoring activities performed by Environmental Monitoring are also discussed, including drinking-water monitoring and nonradiological liquid-effluent monitoring, as well as data management. The primary purposes of monitoring are to evaluate environmental conditions and to provide and interpret data, in compliance with applicable regulations, to ensure protection of human health and the environment. This report compares 1989 environmental-monitoring data with derived concentration guides and with data from previous years. This report also presents results of sampling performed by the Radiological and Environmental Sciences Laboratory and by the United States Geological Survey. 17 refs., 49 figs., 11 tabs

  8. In summary: Idaho National Engineering Laboratory site environmental report for calendar year 1995

    International Nuclear Information System (INIS)

    Roush, D.; Mitchell, R.G.; Peterson, D.

    1996-08-01

    Every human is exposed to natural radiation. This exposure comes from many sources, including cosmic radiation from outer space, naturally-occurring radon, and radioactivity from substances in our bodies. In addition to natural sources of radiation, humans can also be exposed to man-made sources of radiation. Examples of man-made sources include nuclear medicine, X-rays, nuclear weapons testing, and accidents at nuclear power plants. The Idaho National Engineering Laboratory (INEL) is a U.S. Department of Energy (DOE) research facility that deals, in part, with studying nuclear reactors and storing radioactive materials. Careful handling and rigorous procedures do not completely eliminate the risk of releasing radioactivity. So, there is a remote possibility for a member of the public near the INEL to be exposed to radioactivity from the INEL. Extensive monitoring of the environment takes place on and around the INEL. These programs search for radionuclides and other contaminants. The results of these programs are presented each year in a site environmental report. This document summarizes the Idaho National Engineering Laboratory Site Environmental Report for Calendar Year 1995

  9. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure

    NARCIS (Netherlands)

    Oedayrajsingh-Varma, M. J.; van Ham, S. M.; Knippenberg, M.; Helder, M. N.; Klein-Nulend, J.; Schouten, T. E.; Ritt, M. J. P. F.; van Milligen, F. J.

    2006-01-01

    Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were

  10. The Idaho National Engineering Laboratory Site Environmental Report for Calendar Year 1993

    International Nuclear Information System (INIS)

    Mitchell, R.G.

    1994-07-01

    Results of the various environmental monitoring programs for 1993 are presented from the Idaho National Engineering Laboratory (INEL) operations. Although some radioactive materials were discharged during Site operations, concentrations and doses to the surrounding population were of no health consequence and were far less than State of Idaho and Federal health protection guidelines. Chapter 2 summarizes INEL activities related to compliance with environmental regulations and laws for Calendar Year 1993. The major portion of the report summarizes results of the environmental surveillance program conducted by the DOE Radiological and Environmental Sciences Laboratory, which includes the collection of foodstuffs at the INEL boundary and distant offsite locations, and the collection of air and water samples at onsite locations and offsite boundary and distant locations. The report also compares and evaluates the sample results to appropriate federal regulations and standards and discusses implications, if any. The US Geological Survey (USGS) ground-water monitoring program is briefly summarized and data are included in maps showing the spread of contaminants. Effluent monitoring and nonradiological drinking water monitoring are discussed briefly and data are summarized

  11. Curricular Reform: Systems Modeling and Sustainability in Civil and Environmental Engineering at the University of Vermont

    Science.gov (United States)

    Rizzo, D. M.; Hayden, N. J.; Dewoolkar, M.; Neumann, M.; Lathem, S.

    2009-12-01

    Researchers at the University of Vermont were awarded a NSF-sponsored Department Level Reform (DLR) grant to incorporate a systems approach to engineering problem solving within the civil and environmental engineering programs. A systems approach challenges students to consider the environmental, social, and economic aspects within engineering solutions. Likewise, sustainability requires a holistic approach to problem solving that includes economic, social and environmental factors. Our reform has taken a multi-pronged approach in two main areas that include implementing: a) a sequence of three systems courses related to environmental and transportation systems that introduce systems thinking, sustainability, and systems analysis and modeling; and b) service-learning (SL) projects as a means of practicing the systems approach. Our SL projects are good examples of inquiry-based learning that allow students to emphasize research and learning in areas of most interest to them. The SL projects address real-world open-ended problems. Activities that enhance IT and soft skills for students are incorporated throughout the curricula. Likewise, sustainability has been a central piece of the reform. We present examples of sustainability in the SL and modeling projects within the systems courses (e.g., students have used STELLA™ systems modeling software to address the impact of different carbon sequestration strategies on global climate change). Sustainability in SL projects include mentoring home schooled children in biomimicry projects, developing ECHO exhibits and the design of green roofs, bioretention ponds and porous pavement solutions. Assessment includes formative and summative methods involving student surveys and focus groups, faculty interviews and observations, and evaluation of student work.

  12. Overview of environmental surveillance of waste management activities at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Smith, T.H.; Hedahl, T.G.; Wiersma, G.B.; Chew, E.W.; Mann, L.J.; Pointer, T.F.

    1986-02-01

    The Idaho National Engineering Laboratory (INEL), in southeastern Idaho, is a principal center for nuclear energy development for the Department of Energy (DOE) and the US Nuclear Navy. Fifty-two reactors have been built at the INEL, with 15 still operable. Extensive environmental surveillance is conducted at the INEL by DOE's Radiological and Environmental Sciences Laboratory (RESL), the US Geological Survey (USGS), the National Oceanic and Atmospheric Administration (NOAA), EG and G Idaho, Inc., and Westinghouse Idaho Nuclear Company (WINCO). Surveillance of waste management facilities is integrated with the overall INEL Site surveillance program. Air, water, soil, biota, and environmental radiation are monitored or sampled routinely at the INEL. Results to date indicate very small or no impacts from the INEL on the surrounding environment. Environmental surveillance activities are currently underway to address key environmental issues at the INEL. 7 refs., 6 figs., 2 tabs

  13. Hydrology for Engineers, Geologists, and Environmental Professionals

    Science.gov (United States)

    Ince, Simon

    For people who are involved in the applied aspects of hydrology, it is refreshing to find a textbook that begins with a meaningful disclaimer, albeit in fine print on the back side of the frontispiece:“The present book and the accompanying software have been written according to the latest techniques in scientific hydrology. However, hydrology is at best an inexact science. A good book and a good computer software by themselves do not guarantee accurate or even realistic predictions. Acceptable results in the applications of hydrologic methods to engineering and environmental problems depend to a greater extend (sic) on the skills, logical assumptions, and practical experience of the user, and on the quantity and quality of long-term hydrologic data available. Neither the author nor the publisher assumes any responsibility or any liability, explicitly or implicitly, on the results or the consequences of using the information contained in this book or its accompanying software.”

  14. Thermal Environmental Testing of NSTAR Engineering Model Ion Thrusters

    Science.gov (United States)

    Rawlin, Vincent K.; Patterson, Michael J.; Becker, Raymond A.

    1999-01-01

    NASA's New Millenium program will fly a xenon ion propulsion system on the Deep Space 1 Mission. Tests were conducted under NASA's Solar Electric Propulsion Technology Applications Readiness (NSTAR) Program with 3 different engineering model ion thrusters to determine thruster thermal characteristics over the NSTAR operating range in a variety of thermal environments. A liquid nitrogen-cooled shroud was used to cold-soak the thruster to -120 C. Initial tests were performed prior to a mature spacecraft design. Those results and the final, severe, requirements mandated by the spacecraft led to several changes to the basic thermal design. These changes were incorporated into a final design and tested over a wide range of environmental conditions.

  15. A methodological approach of 'environmental engineering' for the rescue and protection of a territory

    International Nuclear Information System (INIS)

    Cautilli, F.; Polizzano, C.; Tassoni, E.; Zarlenga, F.

    1989-02-01

    In this report the methodological process, that should be followed when an environmental protection and restoration problem is dealt with, is described. Moreover the actions that 'the environmental engineer' has to carry out to study every multidisciplinary problem on territory protection and restoration are synthesized, keeping in mind that the territory knowledge and the geological hazard specification are the essential bases for research work. Finally, some typical territory protection actions against the hydrogeological failures, the quarry excavation activity and the hazardous waste disposal impact, are briefly described. (author)

  16. Utilization of electromigration in civil and environmental engineering--processes, transport rates and matrix changes.

    Science.gov (United States)

    Ottosen, Lisbeth M; Christensen, Iben V; Rorig-Dalgård, Inge; Jensen, Pernille E; Hansen, Henrik K

    2008-07-01

    Electromigration (movement of ions in an applied electric field) is utilized for supply or extraction of ions from various porous materials within both civil and environmental engineering. In civil engineering, most research has been conducted on the removal of chlorides from concrete to hinder reinforcement corrosion while in environmental engineering remediation of heavy metal polluted soil is the issue most studied. Never the less, experiments have been conducted with utilization for several other materials and purposes within both engineering fields. Even though there are many topics of common interest in the use of electromigration for the two fields, there is no tradition for collaboration. The present paper is a review with the aim of pointing out areas of shared interest. Focus is laid on the purposes of the different processes, transport rates of various ions in different materials and on changes in the matrix itself. Desorption and dissolution of the target elements into ionic form is a key issue to most of the processes, and can be the limiting step. The removal rate is generally below 1 cm day(- 1), but it can be much less than 1 mm day(- 1) when desorption is slow and insufficient. Matrix changes occurs under the action of the applied electric field and it includes both physico-chemical and hydrological changes. Some of the solid phases is weathered and new can be formed. Increased fundamental understanding of the effects and side effects, when applying the electric field to a porous material, can lead to improvement of the known technologies and possibly to new applications.

  17. Business | College of Engineering & Applied Science

    Science.gov (United States)

    & Environmental Engineering TA Online Application Civil & Environmental Engineering Research in Computer Science - FAQ's Computer Science TA Online Application Ph.D. Program in Computer Science Electrical Engineering Electrical Engineering TA Online Application Electrical Engineering Research

  18. Coupled-Double-Quantum-Dot Environmental Information Engines: A Numerical Analysis

    Science.gov (United States)

    Tanabe, Katsuaki

    2016-06-01

    We conduct numerical simulations for an autonomous information engine comprising a set of coupled double quantum dots using a simple model. The steady-state entropy production rate in each component, heat and electron transfer rates are calculated via the probability distribution of the four electronic states from the master transition-rate equations. We define an information-engine efficiency based on the entropy change of the reservoir, implicating power generators that employ the environmental order as a new energy resource. We acquire device-design principles, toward the realization of corresponding practical energy converters, including that (1) higher energy levels of the detector-side reservoir than those of the detector dot provide significantly higher work production rates by faster states' circulation, (2) the efficiency is strongly dependent on the relative temperatures of the detector and system sides and becomes high in a particular Coulomb-interaction strength region between the quantum dots, and (3) the efficiency depends little on the system dot's energy level relative to its reservoir but largely on the antisymmetric relative amplitudes of the electronic tunneling rates.

  19. Off-road compression-ignition engine emission regulations under the Canadian Environmental Protection Act 1999 : guidance document

    International Nuclear Information System (INIS)

    2006-03-01

    This guide explained the requirements for Off-Road Compression Ignition Engine Emission Regulations established under the Canadian Environmental Protection Act. The regulations are enforced by Environment Canada, which authorizes and monitors the use of the national emissions mark. The regulations prescribe standards for off-road engines that operate as reciprocating, internal combustion engines, other than those that operate under characteristics similar to the Otto combustion cycle and that use a spark plug or other sparking device. The regulations apply to engines that are typically diesel-fuelled and found in construction, mining, farming and forestry machines such as tractors, excavators and log skidders. Four different types of persons are potentially affected by the regulations: Canadian engine manufacturers; distributors of Canadian engines or machines containing Canadian engines; importers of engines or machines for the purpose of sale; and persons not in companies importing engines or machines. Details of emission standards were presented, as well as issues concerning evidence of conformity, importing engines, and special engine cases. Compliance and enforcement details were reviewed, as well as applicable standards and provisions for emission control systems and defeat devices; exhaust emissions; crankcase and smoke emissions; and adjustable parameters. Details of import declarations were reviewed, as well as issues concerning defects and maintenance instructions. 4 tabs., 4 figs

  20. An overview of environmental surveillance of waste management activities at the Idaho National Engineering Laboratory

    Science.gov (United States)

    Smith, T.H.; Chew, E.W.; Hedahl, T.G.; Mann, L.J.; Pointer, T.F.; Wiersma, G.B.

    1986-01-01

    The Idaho National Engineering Laboratory (INEL), in southeastern Idaho, is a principal center for nuclear energy development for the Department of Energy (DOE) and the U.S. Nuclear Navy. Fifty-two reactors have been built at the INEL, with 15 still operable. Extensive environmental surveillance is conducted at the INEL by DOE's Radiological Environmental Sciences Laboratory (RESL), and the U.S. Geological Survey (USGS), the National Oceanic and Atmospheric Administration (NOAA), EG&G Idaho, Inc., and Westinghouse Idaho Nuclear Company (WINCO). Surveillance of waste management facilities radiation is integrated with the overall INEL Site surveillance program. Air, warer, soil, biota, and environmental radiation are monitored or sampled routinely at INEL. Results to date indicate very small or no impacts from INEL on the surrounding environment. Environmental surveillance activities are currently underway to address key environmental issues at the INEL.

  1. Lineage of global civil engineering. Global civil engineering no keifu

    Energy Technology Data Exchange (ETDEWEB)

    Hashimoto, M

    1994-04-15

    This paper considers which way the global civil engineering should go in the future. Civil engineering has now a paradigm with a new dimension debuted as the global environmental problems are taken up specifically. Achieving the target of civil engineering requires a critical review that how the cost effect and efficiency discussions in only the dimensions of the conventional technologies and economies can be incorporated into the dimensions and measures of new fields to create the new horizons. Conceiving the relationship between civil engineered structures and environmental climate encounters the indispensable judgment criterion on how such social scientific conditions as weather, culture, religion, economy, and politics are combined to reach a judgment. The global civil engineering is desired to have the ideas and directional role to work on the ultimate assignment of environment and development called a global environmental problem analytically, comprehensively, innovatively and creatively as the civil engineering science, rather than as a mere existence of one area of the advanced civil engineering science. 5 refs., 1 tab.

  2. Adipose-derived stem cells and BMP-2 delivery in chitosan-based 3D constructs to enhance bone regeneration in a rat mandibular defect model.

    Science.gov (United States)

    Fan, Jiabing; Park, Hyejin; Lee, Matthew K; Bezouglaia, Olga; Fartash, Armita; Kim, Jinku; Aghaloo, Tara; Lee, Min

    2014-08-01

    Reconstructing segmental mandiblular defects remains a challenge in the clinic. Tissue engineering strategies provide an alternative option to resolve this problem. The objective of the present study was to determine the effects of adipose-derived stem cells (ASCs) and bone morphogenetic proteins-2 (BMP-2) in three-dimensional (3D) scaffolds on mandibular repair in a small animal model. Noggin expression levels in ASCs were downregulated by a lentiviral short hairpin RNA strategy to enhance ASC osteogenesis (ASCs(Nog-)). Chitosan (CH) and chondroitin sulfate (CS), natural polysaccharides, were fabricated into 3D porous scaffolds, which were further modified with apatite coatings for enhanced cellular responses and efficient delivery of BMP-2. The efficacy of 3D apatite-coated CH/CS scaffolds supplemented with ASCs(Nog-) and BMP-2 were evaluated in a rat critical-sized mandibular defect model. After 8 weeks postimplantation, the scaffolds treated with ASCs(Nog-) and BMP-2 significantly promoted rat mandibular regeneration as demonstrated by micro-computerized tomography, histology, and immunohistochemistry, compared with the groups treated with ASCs(Nog-) or BMP-2 alone. These results suggest that our combinatorial strategy of ASCs(Nog-)+BMP-2 in 3D apatite microenvironments can significantly promote mandibular regeneration, and these may provide a potential tissue engineering approach to repair large bony defects.

  3. Test Rack Development for Extended Operation of Advanced Stirling Convertors at NASA Glenn Research Center

    Science.gov (United States)

    Dugala, Gina M.

    2010-01-01

    The U.S. Department of Energy, Lockheed Martin Space Systems Company, Sunpower Inc., and NASA Glenn Research Center (GRC) have been developing an Advanced Stirling Radioisotope Generator (ASRG) for use as a power system on space science missions. This generator will make use of free-piston Stirling convertors to achieve higher conversion efficiency than with currently available alternatives. One part of NASA GRC's support of ASRG development includes extended operation testing of Advanced Stirling Convertors (ASCs) developed by Sunpower Inc. and GRC. The ASC consists of a free-piston Stirling engine integrated with a linear alternator. NASA GRC has been building test facilities to support extended operation of the ASCs for several years. Operation of the convertors in the test facility provides convertor performance data over an extended period of time. One part of the test facility is the test rack, which provides a means for data collection, convertor control, and safe operation. Over the years, the test rack requirements have changed. The initial ASC test rack utilized an alternating-current (AC) bus for convertor control; the ASRG Engineering Unit (EU) test rack can operate with AC bus control or with an ASC Control Unit (ACU). A new test rack is being developed to support extended operation of the ASC-E2s with higher standards of documentation, component selection, and assembly practices. This paper discusses the differences among the ASC, ASRG EU, and ASC-E2 test racks.

  4. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    This document analyzes at a pregrammatic level the potential environmental consequences over the next 40 years of alternatives related to the transportation, receipt, processing, and storage of spent nuclear fuel under the responsibility of the US Department of Energy. It also analyzes the site-specific consequences of the Idaho National Engineering Laboratory sitewide actions anticipated over the next 10 years for waste and spent nuclear fuel management and environmental restoration. For pregrammatic spent nuclear fuel management, this document analyzes alternatives of no action, decentralization, regionalization, centralization and the use of the plans that existed in 1992/1993 for the management of these materials. For the Idaho National Engineering Laboratory, this document analyzes alternatives of no action, ten-year plan, minimum and maximum treatment, storage, and disposal of US Department of Energy wastes.

  5. Energy and environmental challenges to chemical engineers

    International Nuclear Information System (INIS)

    McHenry, K.W.

    1991-01-01

    The National Research Council's report, Frontiers in Chemical Engineering, was written four years ago. Three high-priority research areas concerned with energy and the environment were identified in the report: in situ processing, liquid fuels for the future, and responsible management of hazardous wastes. As outlined in the recently released National Energy Strategy, in situ processing is viewed by the Department of Energy (DOE) primarily through its use in enhanced oil recovery, and some research is still funded. Industry, driven by the economics of low oil prices, is doing little research on in situ processing but much more on reservoir characterization, a prerequisite to processing. Research on liquid fuels for the future is driven more by environmental concerns now than by energy security concerns. It appears to be wise policy for the future to try to solve the alternative fuel problem as quickly and simply as possible. Otherwise, the nation will find itself with a costly and complex fuel and vehicle system that may have to be changed again in a generation. For the interim, we should look closely at reformulated gasoline followed by compressed natural gas, if necessary. In the long run, vehicle systems based on electricity seem most promising for the middle of the next century. To deliver this technology we need to capitalize on three new high-priority research areas: batteries, fuel cells, and nuclear power. For chemical engineers, future challenges of a different sort will be added to the technical challenges, among them are explaining to a skeptical public the wisdom of proceeding to design the interim system of alternative fuel(s) and to move expeditiously to a final solution

  6. Effects of heat stimulation and l-ascorbic acid 2-phosphate supplementation on myogenic differentiation of artificial skeletal muscle tissue constructs.

    Science.gov (United States)

    Ikeda, Kazushi; Ito, Akira; Sato, Masanori; Kanno, Shota; Kawabe, Yoshinori; Kamihira, Masamichi

    2017-05-01

    Although skeletal muscle tissue engineering has been extensively studied, the physical forces produced by tissue-engineered skeletal muscles remain to be improved for potential clinical utility. In this study, we examined the effects of mild heat stimulation and supplementation of a l-ascorbic acid derivative, l-ascorbic acid 2-phosphate (AscP), on myoblast differentiation and physical force generation of tissue-engineered skeletal muscles. Compared with control cultures at 37°C, mouse C2C12 myoblast cells cultured at 39°C enhanced myotube diameter (skeletal muscle hypertrophy), whereas mild heat stimulation did not promote myotube formation (differentiation rate). Conversely, AscP supplementation resulted in an increased differentiation rate but did not induce skeletal muscle hypertrophy. Following combined treatment with mild heat stimulation and AscP supplementation, both skeletal muscle hypertrophy and differentiation rate were enhanced. Moreover, the active tension produced by the tissue-engineered skeletal muscles was improved following combined treatment. These findings indicate that tissue culture using mild heat stimulation and AscP supplementation is a promising approach to enhance the function of tissue-engineered skeletal muscles. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  7. Source Release Modeling for the Idaho National Engineering and Environmental Laboratory's Subsurface Disposal Area

    International Nuclear Information System (INIS)

    Becker, B.H.

    2002-01-01

    A source release model was developed to determine the release of contaminants into the shallow subsurface, as part of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) evaluation at the Idaho National Engineering and Environmental Laboratory's (INEEL) Subsurface Disposal Area (SDA). The output of the source release model is used as input to the subsurface transport and biotic uptake models. The model allowed separating the waste into areas that match the actual disposal units. This allows quantitative evaluation of the relative contribution to the total risk and allows evaluation of selective remediation of the disposal units within the SDA

  8. Experimental Engineering Section semiannual progress report, March 1-August 31, 1976. Volume 2. Biotechnology and environmental programs

    Energy Technology Data Exchange (ETDEWEB)

    Pitt, Jr., W. W.; Mrochek, J. E. [comps.

    1978-03-01

    This volume contains the progress report of the biotechnology and environmental programs in the Experimental Engineering Section of the Chemical Technology Division. Research efforts in these programs during this report period have been in five areas: (1) environmental research; (2) centrifugal analyzer development; (3) advanced analytical systems development; (4) bioengineering research; and (5) bioengineering development. Summaries of these programmatic areas are contained in Volume I.

  9. Idaho National Engineering and Environmental Laboratory Site Environmental Report for Calendar Year 1997

    Energy Technology Data Exchange (ETDEWEB)

    R. B. Evans; D. Roush; R. W. Brooks; D. B. Martin

    1998-08-01

    The results of the various monitoring programs for 1997 indicated that radioactivity from the Idaho National Engineering and Environmental Laboratory (INEEL) operations could generally not be distinguished from worldwide fallout and natural radioactivity in the region surrounding the INEEL. Although some radioactive materials were discharged during INEEL operations, concentrations in the offsite environment and doses to the surrounding population were far less than state of Idaho and federal health protection guidelines. The maximum potential population dose from submersion, ingestion, inhalation, and deposition to the approximately 121,500 people residing within an 80-km (50-mi) radius from the geographical center of the INEEL was estimated to be 0.2 person-rem (2 x 10-3 person-Sv) using the MDIFF air dispersion model. This population dose is less than 0.0005% of the estimated 43,700 person-rem (437 person-Sv) population dose from background radioactivity.

  10. Advances in complex societal, environmental and engineered systems

    CERN Document Server

    Essaaidi, Mohammad

    2017-01-01

    This book addresses recent technological progress that has led to an increased complexity in many natural and artificial systems. The resulting complexity research due to the emergence of new properties and spatio-temporal interactions among a large number of system elements - and between the system and its environment - is the primary focus of this text. This volume is divided into three parts: Part one focuses on societal and ecological systems, Part two deals with approaches for understanding, modeling, predicting and mastering socio-technical systems, and Part three includes real-life examples. Each chapter has its own special features; it is a self-contained contribution of distinguished experts working on different fields of science and technology relevant to the study of complex systems. Advances in Complex Systems of Contemporary Reality: Societal, Environmental and Engineered Systems will provide postgraduate students, researchers and managers with qualitative and quantitative methods for handling th...

  11. Environmental implications and applications of engineered ...

    Science.gov (United States)

    This review focus on environmental implications and applications of engineered magnetite (Fe3O4) nanoparticles (MNPs) as a single phase or a component of a hybrid nanocomposite that take advantages of their superparamagnetism and high surface area. MNPs are synthesized via co-precipitation, thermal decomposition, hydrothermal process, emulsion, and microbial process. Aggregation/sedimentation and transport of MNPs depend on surface charge of MNPs and geochemical parameters such as pH, ionic strength, and organic matter. MNPs generally have low toxicity to humans and ecosystem. MNPs are used for making excellent anode electrode materials in lithium-ion battery, for constructing biosensors, and for catalyzing a variety of chemical reactions. MNPs are used for air cleanup and carbon sequestration. MNP nanocomposites are made as antimicrobial agent for water disinfection and flocculants for water treatment. Conjugated MNPs are widely used for adsorptive/separative removal of organics, dye, oil, arsenic, Cr(VI), heavy metals, radionuclides, and rare earth elements. MNPs can degrade organic/inorganic contaminants via chemical reduction or oxidation in water, sediment, and soil. Future studies should further explore mechanisms of MNP interactions with other nanomaterials and contaminants, economic and green approaches of MNP synthesis, and field scale demonstration of MNP utilization. Submit to Journal of Hazardous Materials.

  12. Environmental Analysis

    Science.gov (United States)

    1980-01-01

    Burns & McDonnell Engineering's environmental control study is assisted by NASA's Computer Software Management and Information Center's programs in environmental analyses. Company is engaged primarily in design of such facilities as electrical utilities, industrial plants, wastewater treatment systems, dams and reservoirs and aviation installations. Company also conducts environmental engineering analyses and advises clients as to the environmental considerations of a particular construction project. Company makes use of many COSMIC computer programs which have allowed substantial savings.

  13. Engineer Ethics

    International Nuclear Information System (INIS)

    Lee, Dae Sik; Kim, Yeong Pil; Kim, Yeong Jin

    2003-03-01

    This book tells of engineer ethics such as basic understanding of engineer ethics with history of engineering as a occupation, definition of engineering and specialized job and engineering, engineer ethics as professional ethics, general principles of ethics and its limitation, ethical theory and application, technique to solve the ethical problems, responsibility, safety and danger, information engineer ethics, biotechnological ethics like artificial insemination, life reproduction, gene therapy and environmental ethics.

  14. Design and characterization of a biodegradable double-layer scaffold aimed at periodontal tissue-engineering applications.

    Science.gov (United States)

    Requicha, João F; Viegas, Carlos A; Hede, Shantesh; Leonor, Isabel B; Reis, Rui L; Gomes, Manuela E

    2016-05-01

    The inefficacy of the currently used therapies in achieving the regeneration ad integrum of the periodontium stimulates the search for alternative approaches, such as tissue-engineering strategies. Therefore, the core objective of this study was to develop a biodegradable double-layer scaffold for periodontal tissue engineering. The design philosophy was based on a double-layered construct obtained from a blend of starch and poly-ε-caprolactone (30:70 wt%; SPCL). A SPCL fibre mesh functionalized with silanol groups to promote osteogenesis was combined with a SPCL solvent casting membrane aiming at acting as a barrier against the migration of gingival epithelium into the periodontal defect. Each layer of the double-layer scaffolds was characterized in terms of morphology, surface chemical composition, degradation behaviour and mechanical properties. Moreover, the behaviour of seeded/cultured canine adipose-derived stem cells (cASCs) was assessed. In general, the developed double-layered scaffolds demonstrated adequate degradation and mechanical behaviour for the target application. Furthermore, the biological assays revealed that both layers of the scaffold allow adhesion and proliferation of the seeded undifferentiated cASCs, and the incorporation of silanol groups into the fibre-mesh layer enhance the expression of a typical osteogenic marker. This study allowed an innovative construct to be developed, combining a three-dimensional (3D) scaffold with osteoconductive properties and with potential to assist periodontal regeneration, carrying new possible solutions to current clinical needs. Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd.

  15. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement

    International Nuclear Information System (INIS)

    1994-06-01

    This volume contains the following attachments: transportation of Naval spent nuclear fuel; description of Naval spent nuclear receipt and handling at the Expended Core Facility at the Idaho National Engineering Laboratory; comparison of storage in new water pools versus dry container storage; description of storage of Naval spent nuclear fuel at servicing locations; description of receipt, handling, and examination of Naval spent nuclear fuel at alternate DOE facilities; analysis of normal operations and accident conditions; and comparison of the Naval spent nuclear fuel storage environmental assessment and this environmental impact statement

  16. Designation of Environmental Impacts and Damages of Turbojet Engine: A Case Study with GE-J85

    OpenAIRE

    Altuntas, Onder

    2014-01-01

    Between the troposphere and stratosphere layers of the atmosphere is a critical zone for collecting emissions and negative effects on the Earth (ecological, humanity, and resources). Aircrafts are the main causes of the impacts in this layer. In this study, environmental effects (Damages, Specific Fuel Consumption Impact-SFCI and Thrust Environmental Impact-TEI) of different fueled (Jet-A and Liquid Hydrogen-H2) jet engines (a case study with GE-J85) are investigated. This comparison was made...

  17. Evaluation and Validation of Organic Materials for Advanced Stirling Convertors (ASCs): Overview

    Science.gov (United States)

    Shin, Euy-Sik Eugene

    2015-01-01

    Various organic materials are used as essential parts in Stirling Convertors for their unique properties and functionalities such as bonding, potting, sealing, thread locking, insulation, and lubrication. More efficient Advanced Stirling Convertors (ASC) are being developed for future space applications especially with a long mission cycle, sometimes up to 17 years, such as deep space exploration or lunar surface power or Mars rovers, and others. Thus, performance, durability, and reliability of those organics should be critically evaluated in every possible material-process-fabrication-service environment relations based on their mission specifications. In general, thermal stability, radiation hardness, outgassing, and material compatibility of the selected organics have been systematically evaluated while their process and fabrication conditions and procedures were being optimized. Service environment-simulated long term aging tests up to 4 years were performed as a function of temperature for durability assessment of the most critical organic material systems.

  18. The Role of Alternative Testing Strategies in Environmental Risk Assessment of Engineered Nanomaterials

    OpenAIRE

    Hjorth, Rune; Holden, Patricia; Hansen, Steffen Foss; Colman, Ben; Grieger, Khara; Hendren, Christine

    2017-01-01

    Within toxicology there is a pressure to find new test systems and organisms to replace, reduce and refine animal testing. In nanoecotoxicology the need for alternative testing strategies (ATS) is further emphasized as the validity of tests and risk assessment practices developed for dissolved chemicals are challenged. Nonetheless, standardized whole organism animal testing is still considered the gold standard for environmental risk assessment. Advancing risk analysis of engineered nanomater...

  19. Studies on Experimental Ontology and Knowledge Service Development in Bio-Environmental Engineering

    Science.gov (United States)

    Zhang, Yunliang

    2018-01-01

    The existing domain-related ontology and information service patterns are analyzed, and the main problems faced by the experimental scheme knowledge service were clarified. The ontology framework model for knowledge service of Bio-environmental Engineering was proposed from the aspects of experimental materials, experimental conditions and experimental instruments, and this ontology will be combined with existing knowledge organization systems to organize scientific and technological literatures, data and experimental schemes. With the similarity and priority calculation, it can improve the related domain research.

  20. HPV genotype profile in a Norwegian cohort with ASC-US and LSIL cytology with three year cumulative risk of high grade cervical neoplasia.

    Science.gov (United States)

    Lie, A K; Tropé, A; Skare, G B; Bjørge, T; Jonassen, C M; Brusegard, K; Lönnberg, S

    2018-01-01

    To explore the HPVgenotype profile in Norwegian women with ASC-US/LSIL cytology and the subsequent risk of high-grade cervical neoplasia (CIN 3+). In this observational study delayed triage of ASC-US/LSIL of 6058 women were included from 2005 to 2010. High-risk HPV detection with Hybrid Capture 2 (HC2) was used and the HC2+ cases were genotyped with in-house nmPCR. Women were followed-up for histologically confirmed CIN3+ within three years of index HPV test by linkage to the screening databases at the Cancer Registry of Norway. HC2 was positive in 45% (2756/6058) of the women. Within 3years CIN3+ was diagnosed in 26% of womenrisk for CIN3+. Among older women, all 13 high-risk genotypes as single infection were associated with >20% risk of CIN3+. Further studies are necessary to risk stratify the individual genotypes to reduce the number of colposcopies in Norway. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Compatibility of Porous Chitosan Scaffold with the Attachment and Proliferation of human Adipose-Derived Stem Cells In Vitro

    Directory of Open Access Journals (Sweden)

    Gomathysankar S

    2016-11-01

    Full Text Available Adipose-derived stem cells (ASCs have potential applications in the repair and regeneration of various tissues and organs. The use of various scaffold materials as an excellent template for mimicking the extracellular matrix to induce the attachment and proliferation of different cell types has always been of interest in the field of tissue engineering because ideal biomaterials are in great demand. Chitosan, a marine polysaccharide, have wide clinical applications and it acts as a promising scaffold for cell migration and proliferation. ASCs, with their multi-differentiation potential, and chitosan, with its great biocompatibility with ASCs, were investigated in the present study. ASCs were isolated and were characterized by two different methods: immunocytochemistry and flow cytometry, using the mesenchymal stem cell markers CD90, CD105, CD73 and CD29. The ASCs were then induced to differentiate into adipogenic, osteogenic and chondrogenic lineages. These ASCs were incorporated into a porous chitosan scaffold (PCS, and their structural morphology was studied using a scanning electron microscope and hematoxylin and eosin staining. The proliferation rate of the ASCs on the PCS was assessed using a PrestoBlue viability assay. The results indicated that the PCS provides an excellent template for the adhesion and proliferation of ASCs. Thus, this study revealed that PCS is a promising biomaterial for inducing the proliferation of ASCs, which could lead to successful tissue reconstruction in the field of tissue engineering.

  2. Validation of the GPU-Accelerated CFD Solver ELBE for Free Surface Flow Problems in Civil and Environmental Engineering

    Directory of Open Access Journals (Sweden)

    Christian F. Janßen

    2015-07-01

    Full Text Available This contribution is dedicated to demonstrating the high potential and manifold applications of state-of-the-art computational fluid dynamics (CFD tools for free-surface flows in civil and environmental engineering. All simulations were performed with the academic research code ELBE (efficient lattice boltzmann environment, http://www.tuhh.de/elbe. The ELBE code follows the supercomputing-on-the-desktop paradigm and is especially designed for local supercomputing, without tedious accesses to supercomputers. ELBE uses graphics processing units (GPU to accelerate the computations and can be used in a single GPU-equipped workstation of, e.g., a design engineer. The code has been successfully validated in very different fields, mostly related to naval architecture and mechanical engineering. In this contribution, we give an overview of past and present applications with practical relevance for civil engineers. The presented applications are grouped into three major categories: (i tsunami simulations, considering wave propagation, wave runup, inundation and debris flows; (ii dam break simulations; and (iii numerical wave tanks for the calculation of hydrodynamic loads on fixed and moving bodies. This broad range of applications in combination with accurate numerical results and very competitive times to solution demonstrates that modern CFD tools in general, and the ELBE code in particular, can be a helpful design tool for civil and environmental engineers.

  3. Advanced Stirling Radioisotope Generator EU2 Anomaly Investigation

    Science.gov (United States)

    Lewandowski, Edward J.; Dobbs, Michael W.; Oriti, Salvatore M.

    2016-01-01

    The Advanced Stirling Radioisotope Generator (ASRG) Engineering Unit 2 (EU2) is the highest fidelity electrically-heated Stirling radioisotope generator built to date. NASA Glenn Research Center (GRC) completed the assembly of the ASRG EU2 in September, 2014 using hardware from the now cancelled ASRG flight development project. The ASRG EU2 integrated the first pair of Sunpower's ASC-E3 Stirling convertors (ASC-E3 #1 and #2) in an aluminum generator housing with Lockheed Martin's Engineering Development Unit (EDU) 4 controller. After just 179 hours of EU2 generator operation, the first power fluctuation occurred on ASC-E3 #1. The first power fluctuation occurred 175 hours later on ASC-E3 #2. Over time, the power fluctuations became more frequent on both convertors and larger in magnitude. Eventually the EU2 was shut down in January, 2015. An anomaly investigation was chartered to determine root cause of the power fluctuations and other anomalous observations. A team with members from GRC, Sunpower, and Lockheed Martin conducted a thorough investigation of the EU2 anomalies. Findings from the EU2 disassembly identified proximate causes of the anomalous observations. Discussion of the team's assessment of the primary possible failure theories, root cause, and conclusions is provided. Recommendations are made for future Stirling generator development to address the findings from the anomaly investigation. Additional findings from the investigation are also discussed.

  4. 2-D Resistivity Assessment of Subsurface Characterization and its Engineering and Environmental Implications at SiLC

    Science.gov (United States)

    Nordiana, M. M.; Azwin, I. N.; Saad, Rosli; Jia, Teoh Ying; Anderson, A. B.; Tonnizam, Edy; Taqiuddin Zakaria, Muhamad

    2017-04-01

    The role of geophysics in Environmental Earth Sciences and Engineering is considered. In the developing era, geophysics has mainly contributed in investigation of new constructions such as tunnels, road, dams and high-rise buildings. This study was carried out to assess the foundation depths around a construction site in the Southern Industrial & Logistics Clusters (SiLC), Nusajaya, Johor using 2-D resistivity method. The 2-D resistivity method was carried out with a view to characterize different subsurface geological and to provide the engineering and environmental geophysical characterization of the study area. Measurements of eight 2-D resistivity profile using Pole-dipole array with 2 m minimum electrode spacing was taken with the use of ABEM Terrameter SAS4000 and ES10-64C selector. The results are presented as inversion model resistivity with the outline of the survey line. The inversion model resistivity from L1-L8 obtained is characterized by resistivity range of 1-8000 ohm-m. This range indicates the occurrence of silt, clay, sandy clay and sand whose ranges are; 10-100 ohm-m, 1-100 ohm-m, 100-800 ohm-m and 100-3000 ohm-m respectively. However, there was a boulder with range of >5000 ohm-m and saturated zone (1-20 ohm-m) which may indicate the weak zones of the study area. The 2-D resistivity method is not intended to replace borings, except in specific cases where information gathered would be sufficient to address the intended engineering and environmental purpose.

  5. Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs)

    Science.gov (United States)

    Romero-Franco, Michelle; Godwin, Hilary A; Bilal, Muhammad

    2017-01-01

    The potential environmental impact of nanomaterials is a critical concern and the ability to assess these potential impacts is top priority for the progress of sustainable nanotechnology. Risk assessment tools are needed to enable decision makers to rapidly assess the potential risks that may be imposed by engineered nanomaterials (ENMs), particularly when confronted by the reality of limited hazard or exposure data. In this review, we examine a range of available risk assessment frameworks considering the contexts in which different stakeholders may need to assess the potential environmental impacts of ENMs. Assessment frameworks and tools that are suitable for the different decision analysis scenarios are then identified. In addition, we identify the gaps that currently exist between the needs of decision makers, for a range of decision scenarios, and the abilities of present frameworks and tools to meet those needs. PMID:28546894

  6. Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs

    Directory of Open Access Journals (Sweden)

    Michelle Romero-Franco

    2017-05-01

    Full Text Available The potential environmental impact of nanomaterials is a critical concern and the ability to assess these potential impacts is top priority for the progress of sustainable nanotechnology. Risk assessment tools are needed to enable decision makers to rapidly assess the potential risks that may be imposed by engineered nanomaterials (ENMs, particularly when confronted by the reality of limited hazard or exposure data. In this review, we examine a range of available risk assessment frameworks considering the contexts in which different stakeholders may need to assess the potential environmental impacts of ENMs. Assessment frameworks and tools that are suitable for the different decision analysis scenarios are then identified. In addition, we identify the gaps that currently exist between the needs of decision makers, for a range of decision scenarios, and the abilities of present frameworks and tools to meet those needs.

  7. Biochemical, Environmental Engineering and Water Treatment

    International Nuclear Information System (INIS)

    Ahmed, A.A.E.; Ibrahem, I.M.

    2004-01-01

    to Environmental Considerations - The environmental impacts of a proposed wastewater treatment facility are as important,t, if not more so, as cost considerations, a few comments regarding applicable environmental considerations that must also be addressed are appropriate. - The environmental evaluations should focus on social, technical, ecological, economic, political, legal, and institutional (STEEPLI) criteria. - Environmental Impact Statement (EIS) prepared for any proposed governmental action that is determined to have a significant impact on the quality of the human environment. - The regulations ensure that the probable environmental effects are identified, that a reasonable number of alternative actions and their environmental impacts are considered, that the environmental information is available for public understanding and scrutiny, and that the public and governmental agencies participate as a part of the decision process. - All pertinent regulations and the inherent participate afforded must be disclosed in the EIS. - National Environmental Policy Act of USA (NEP A ) neither prohibits nor permits any action but requires full disclosure of environmental information and public participation in the decision making process

  8. Expansion of the Idaho National Engineering Laboratory Research Center: Environmental assessment

    International Nuclear Information System (INIS)

    1994-03-01

    The US Department of Energy (DOE) proposes to expand and upgrade facilities at the Idaho National Engineering Laboratory (INEL) Research Center (IRC) by constructing a research laboratory addition on the northeast corner of existing laboratory building; upgrading the fume hood system in the existing laboratory building; and constructing a hazardous waste handling facility and a chemical storage building. The DOE also proposes to expand the capabilities of biotechnology research programs by increasing use of radiolabeled compounds to levels in excess of current facility limits for three radionuclides (carbon-14, sulfur-35, and phosphorus-32). This Environmental assessment identifies the need for the new facilities, describes the proposed projects and environmental setting, and evaluates the potential environmental effects. Impacts associated with current operation are discussed and established as a baseline. Impacts associated with the proposed action and cumulative impacts are described against this background. Alternatives to the proposed action (No action; Locating proposed facilities at a different site) are discussed and a list of applicable regulations is provided. The no action alternative is continuation of existing operations at existing levels as described in Section 4 of this EA. Proposed facilities could be constructed at a different location, but these facilities would not be useful or practical since they are needed to provide a support function for IRC operations. Further, the potential environmental impacts would not be reduced if a different site was selected

  9. 40 CFR 91.115 - Certification procedure-determining engine power and engine families.

    Science.gov (United States)

    2010-07-01

    ... engine power and engine families. 91.115 Section 91.115 Protection of Environment ENVIRONMENTAL... engine power and engine families. (a) Engine power must be calculated using SAE J1228. This procedure has... engine families as specified by paragraph (c) of this section, comprised of engines expected to have...

  10. Environmental Management Plan for the Chemical Engineering Laboratory (LIQ) of the National University of Colombia, Bogotá

    OpenAIRE

    Javier Gama Chávez; Martha Lozano García; Paulo César Narváez Rincón; Óscar Javier Suárez Medina

    2004-01-01

    An Enviromental Management Plan was formulated with the objective of improving the environmental performance of the Chemical Engineering Laboratory (LIQ). The plan was supported on the principles established by the ISO 140001 standard. In a first step, an environmental politic was proposed. Next, by means of an initial review of the laboratory, the most significant impacts related to the activities developed in the Laboratory were identified: dangerous chemical wastes accumulation, water cont...

  11. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement. Volume 2, Part A

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    This document analyzes at a programmatic level the potential environmental consequences over the next 40 years of alternatives related to the transportation, receipt, processing, and storage of spent nuclear fuel under the responsibility of the US Department of Energy. It also analyzes the site-specific consequences of the Idaho National Engineering Laboratory sitewide actions anticipated over the next 10 years for waste and spent nuclear fuel management and environmental restoration. For programmatic spent nuclear fuel management this document analyzes alternatives of no action, decentralization, regionalization, centralization and the use of the plans that existed in 1992/1993 for the management of these materials. For the Idaho National Engineering Laboratory, this document analyzes alternatives of no action, ten-year plan, minimum and maximum and maximum treatment, storage, and disposal of US Department of Energy wastes.

  12. 3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration

    Science.gov (United States)

    Hu, Yu; Wu, Yao; Gou, Zhiyuan; Tao, Jie; Zhang, Jiumeng; Liu, Qianqi; Kang, Tianyi; Jiang, Shu; Huang, Siqing; He, Jiankang; Chen, Shaochen; Du, Yanan; Gou, Maling

    2016-08-01

    Tissue engineered conduits have great promise for bridging peripheral nerve defects by providing physical guiding and biological cues. A flexible method for integrating support cells into a conduit with desired architectures is wanted. Here, a 3D-printing technology is adopted to prepare a bio-conduit with designer structures for peripheral nerve regeneration. This bio-conduit is consisted of a cryopolymerized gelatin methacryloyl (cryoGelMA) gel cellularized with adipose-derived stem cells (ASCs). By modeling using 3D-printed “lock and key” moulds, the cryoGelMA gel is structured into conduits with different geometries, such as the designed multichannel or bifurcating and the personalized structures. The cryoGelMA conduit is degradable and could be completely degraded in 2-4 months in vivo. The cryoGelMA scaffold supports the attachment, proliferation and survival of the seeded ASCs, and up-regulates the expression of their neurotrophic factors mRNA in vitro. After implanted in a rat model, the bio-conduit is capable of supporting the re-innervation across a 10 mm sciatic nerve gap, with results close to that of the autografts in terms of functional and histological assessments. The study describes an indirect 3D-printing technology for fabricating cellularized designer conduits for peripheral nerve regeneration, and could lead to the development of future nerve bio-conduits for clinical use.

  13. 40 CFR 1033.130 - Instructions for engine remanufacturing or engine installation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Instructions for engine remanufacturing or engine installation. 1033.130 Section 1033.130 Protection of Environment ENVIRONMENTAL... and Related Requirements § 1033.130 Instructions for engine remanufacturing or engine installation. (a...

  14. The Idaho National Engineering Laboratory Site environmental report for calendar year 1988

    International Nuclear Information System (INIS)

    Hoff, D.L.; Mitchell, R.G.; Moore, R.

    1989-06-01

    This report describes the monitoring program, the collection of foodstuffs at the Idaho National Engineering Laboratory (INEL) boundary and distant offsite locations, and the collection of air and water samples at Site locations and offsite boundary and distant locations. The report also compares and evaluates the samples results, discussing implications, if any. Significant environmental activities at the INEL Site during 1988, nonradioactive and radioactive effluent monitoring at the Site, and the US Geological Survey (USGS) ground-water monitoring program are also summarized. 42 refs., 15 figs., 12 tabs

  15. Martian Surface Boundary Layer Characterization: Enabling Environmental Data for Science, Engineering and Human Exploration

    Science.gov (United States)

    England, C.

    2000-01-01

    For human or large robotic exploration of Mars, engineering devices such as power sources will be utilized that interact closely with the Martian environment. Heat sources for power production, for example, will use the low ambient temperature for efficient heat rejection. The Martian ambient, however, is highly variable, and will have a first order influence on the efficiency and operation of all large-scale equipment. Diurnal changes in temperature, for example, can vary the theoretical efficiency of power production by 15% and affect the choice of equipment, working fluids, and operating parameters. As part of the Mars Exploration program, missions must acquire the environmental data needed for design, operation and maintenance of engineering equipment including the transportation devices. The information should focus on the variability of the environment, and on the differences among locations including latitudes, altitudes, and seasons. This paper outlines some of the WHY's, WHAT's and WHERE's of the needed data, as well as some examples of how this data will be used. Environmental data for engineering design should be considered a priority in Mars Exploration planning. The Mars Thermal Environment Radiator Characterization (MTERC), and Dust Accumulation and Removal Technology (DART) experiments planned for early Mars landers are examples of information needed for even small robotic missions. Large missions will require proportionately more accurate data that encompass larger samples of the Martian surface conditions. In achieving this goal, the Mars Exploration program will also acquire primary data needed for understanding Martian weather, surface evolution, and ground-atmosphere interrelationships.

  16. Engineered wetlands : an innovative environmental solution

    International Nuclear Information System (INIS)

    Wallace, S.; Davis, B.M.

    2008-01-01

    Engineered wetlands are now considered as an emerging technology for the in situ remediation of hydrocarbon-contaminated soil and waters. Engineered wetlands incorporate a horizontal subsurface flow gravel bed reactor lined with impermeable liners, and are equipped with forced bed aeration systems in order to enhance oxygen delivery to the wetland's aerobic micro-organisms. The wetlands typically emphasize specific characteristics of wetland ecosystems to improve treatment capacities. This article discussed an engineered wetlands installed at a set of pipeline terminals as well as at a former British Petroleum (BP) refinery. The pipeline terminal generated contact wastewater containing BTEX and ammonia, and a subsurface engineered wetland was built in 1998. To date, the 16,000 2 foot wetland has treated a flow-equalized input of approximately 1.5 m 3 per day of contaminants. At the refinery, a wetland treatment system was designed to treat 6000 m 3 of benzene, toluene, ethylbenzene and xylene (BTEX) and volatile organic compounds (VOCs). The treatment site consists of a golf course, river front trails, and a white water kayak course. A cascade aeration system was used for iron oxidation and air-stripping. A soil matrix biofilter was used for passive gas phase benzene removal, as well as for the removal of ferric hydroxide precipitates. It was concluded that engineered wetlands can offer long-term solutions to site remediation challenges. 1 fig

  17. Dam construction as an engineering solution for water supply problem : environmental thrusts

    Energy Technology Data Exchange (ETDEWEB)

    Hosseini, A.H. [Alberta Univ., Edmonton, AB (Canada). Dept. of Civil and Environmental Engineering

    2004-09-01

    Water supply management and the potential impacts associated with engineering practices in water supply systems were examined. Global aspects of increasing water demand were presented and compared with populations, urbanization and water demand. Engineering practices in waterworks developments such as dam construction, river intakes, infiltration galleries, wells, boreholes and adits were also discussed. Construction of large dams and the problems associated with damming the rivers were studied as large dams generally have substantial impacts on rivers, watersheds and aquatic ecosystems, leading to the irreversible loss of species populations and ecosystems. These problems include negative impacts on the terrestrial ecosystem, greenhouse gas emissions from reservoirs due to decaying vegetation and carbon inflows from the catchment, changes in flow regimes, trapping of sediments and nutrients behind a dam, blocking migration of aquatic organisms, as well as negative impacts on flood plain ecosystems and fisheries. In addition, a case study, on the environmental impacts associated with damming in Three Gorges Valley in China was presented. 9 refs., 8 figs.

  18. Short-Term and Long-Term Technology Needs/Matching Status at Idaho National Engineering and Environmental Laboratory

    International Nuclear Information System (INIS)

    Claggett, S.L.

    1999-01-01

    This report identifies potential technology deployment opportunities for the Environmental Management (EM) programs at the Idaho National Engineering and Environmental Laboratory (INEEL). The focus is on identifying candidates for Accelerated Site Technology Deployment (ASTD) proposals within the Environmental Restoration and Waste Management areas. The 86 technology needs on the Site Technology Coordination Group list were verified in the field. Six additional needs were found, and one listed need was no longer required. Potential technology matches were identified and then investigated for applicability, maturity, cost, and performance. Where promising, information on the technologies was provided to INEEL managers for evaluation. Eleven potential ASTD projected were identified, seven for near-term application and four for application within the next five years

  19. Engineering Students' Sustainability Approaches

    Science.gov (United States)

    Haase, S.

    2014-01-01

    Sustainability issues are increasingly important in engineering work all over the world. This article explores systematic differences in self-assessed competencies, interests, importance, engagement and practices of newly enrolled engineering students in Denmark in relation to environmental and non-environmental sustainability issues. The…

  20. The Idaho National Engineering Laboratory site environmental report for calendar year 1989

    International Nuclear Information System (INIS)

    Hoff, D.L.; Mitchell, R.G.; Bowman, G.C.; Moore, R.

    1990-06-01

    To verify that exposures resulting from operations at the Department of Energy (DOE) nuclear facilities have remained very small, each site at which nuclear activities are underway operates an environmental surveillance program to monitor the air, water and any other pathway where radionuclides from operations might conceivably reach workers or members of the public. This report presents data collected in 1989 for the routine environmental surveillance program conducted by the Radiological and Environmental Sciences Laboratory (RESL) of DOE and the US Geological Survey (USGS) at the Idaho National Engineering Laboratory (INEL) site. The environmental surveillance program for the INEL and vicinity for 1989 included the collection and analysis of samples from potential exposure pathways. Three basic groups of samples were collected. Those collected within the INEL boundaries will be referred to as onsite samples. Samples collected outside, but near, the Site boundaries will be referred to as boundary samples or part of a group of offsite samples. Samples collected from locations considerably beyond the Site boundaries will be referred to as distant samples or part of the offsite group. With the exception of Craters of the Moon National Monument, the distant locations are sufficiently remote from the Site to ensure that detectable radioactivity is primarily due to natural background sources or sources other than INEL operations. 35 refs., 14 figs., 13 tabs

  1. Astronomical performance of the engineering model Ørsted Advanced Stellar Compass

    DEFF Research Database (Denmark)

    Eisenman, Allan R.; Liebe, Carl Christian; Jørgensen, John Leif

    1996-01-01

    of its star tracker, the Advanced Stellar Compass (ASC). The ASC features low cost, low mass, low power, low magnetic disturbance, autonomous operation, a high level of functionality and the high precision. These features are enabled by the use of advanced optical and electronic design which permit...

  2. Bio energy: Environment and Environmental Engineering

    International Nuclear Information System (INIS)

    Soma, Morten; Noreng, Katrina; Soerensen, Heidi; Teslo, Einar; Daehlen, Knut; Liodden, Ole Joergen; Wilhelmsen, Gunnar; Hohle, Erik Eid

    2001-01-01

    This is Chapter 5 of the book ''Bio energy - Environment, technique and market''. Its main sections are: (1) Environmental issues in the use of energy, (2) Environmental issues in the production of biomass, (3) Forestry, (4) Agriculture, (5) Environmental issues in fuel production and storage, (6) Environmental issues in combustion, (7) Environmental issues in using bio fuel, (8) Life cycle analyses, (9) Laws, regulations and norms for the use of bio fuel. Unlike the other sections, the one on laws is mostly concerned with Norwegian conditions

  3. Environmental Management Plan for the Chemical Engineering Laboratory (LIQ of the National University of Colombia, Bogotá

    Directory of Open Access Journals (Sweden)

    Javier Gama Chávez

    2004-01-01

    Full Text Available An Enviromental Management Plan was formulated with the objective of improving the environmental performance of the Chemical Engineering Laboratory (LIQ. The plan was supported on the principles established by the ISO 140001 standard. In a first step, an environmental politic was proposed. Next, by means of an initial review of the laboratory, the most significant impacts related to the activities developed in the Laboratory were identified: dangerous chemical wastes accumulation, water contamination by effusions generation and air contamination. These impacts were the base for formulating following and control programs, furthermire, a training an communication program was done. All the programs, including the requiered documents and procedures, were published in the Environmental Management Plan and the Environmental Procedures Manual.

  4. Engineered wetlands : an innovative environmental solution

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, S.; Davis, B.M. [Jacques Whitford NAWE, White Bear Lake, MN (United States)

    2008-03-15

    Engineered wetlands are now considered as an emerging technology for the in situ remediation of hydrocarbon-contaminated soil and waters. Engineered wetlands incorporate a horizontal subsurface flow gravel bed reactor lined with impermeable liners, and are equipped with forced bed aeration systems in order to enhance oxygen delivery to the wetland's aerobic micro-organisms. The wetlands typically emphasize specific characteristics of wetland ecosystems to improve treatment capacities. This article discussed an engineered wetlands installed at a set of pipeline terminals as well as at a former British Petroleum (BP) refinery. The pipeline terminal generated contact wastewater containing BTEX and ammonia, and a subsurface engineered wetland was built in 1998. To date, the 16,000{sup 2} foot wetland has treated a flow-equalized input of approximately 1.5 m{sup 3} per day of contaminants. At the refinery, a wetland treatment system was designed to treat 6000 m{sup 3} of benzene, toluene, ethylbenzene and xylene (BTEX) and volatile organic compounds (VOCs). The treatment site consists of a golf course, river front trails, and a white water kayak course. A cascade aeration system was used for iron oxidation and air-stripping. A soil matrix biofilter was used for passive gas phase benzene removal, as well as for the removal of ferric hydroxide precipitates. It was concluded that engineered wetlands can offer long-term solutions to site remediation challenges. 1 fig.

  5. Critical issues in water and wastewater treatment. Proceedings of the 1994 national conference on environmental engineering

    International Nuclear Information System (INIS)

    Ryan, J.N.; Edwards, M.

    1994-01-01

    This proceedings, Critical Issues in Water and Wastewater, contains short versions of most of the 114 papers presented at the 1994 Specialty Conference on Environmental Engineering held in Boulder, Colorado on July 11 to 13, 1994. These papers are organized into 23 distinct sessions that focus primarily on water treatment, water distribution, and wastewater treatment. Some of the topics discussed concern microbes in drinking water, contaminated groundwater remediation, and the effects of floods on hazardous waste sites. To summarize, this proceedings provides a practical and timely reference for engineers interested in the current state of water and wastewater concerns

  6. Should LSIL with ASC-H (LSIL-H in cervical smears be an independent category? A study on SurePath™ specimens with review of literature

    Directory of Open Access Journals (Sweden)

    Shidham Vinod B

    2007-03-01

    Full Text Available Abstract Background Cervical smears exhibiting unequivocal features of 'low grade squamous intraepithelial lesion' (LSIL are occasionally also admixed with some cells suspicious for, but not diagnostic of, 'high grade squamous intraepithelial lesion' (HSIL. Only a few studies, mostly reported as abstracts, have evaluated this concurrence. In this study, we evaluate the current evidence that favors a distinct category for "LSIL, cannot exclude HSIL" (LSIL-H, and suggest a management algorithm based on combinations of current ASCCP guidelines for related interpretations. Methods We studied SurePath™ preparations of cervical specimens from various institutions during one year period. Cytohisto correlation was performed in cases with cervical biopsies submitted to our institution. The status of HPV DNA testing was also noted in some LSIL-H cases with biopsy results. Results Out of 77,979 cases 1,970 interpreted as LSIL (1,523, LSIL-H (146, 'atypical squamous cells, cannot exclude HSIL' (ASC-H (109, and HSIL (192 were selected. Concurrent biopsy results were available in 40% (Total 792 cases: 557 LSIL, 88 LSIL-H, 38 ASCH, and 109 HSIL. Biopsy results were grouped into A. negative for dysplasia (ND, B. low grade (HPV, CIN1, CIN1 with HPV, and C. high grade (CIN 2 and above. The positive predictive values for various biopsy results in relation to initial cytopathologic interpretation were: a. LSIL: (557 cases: ND 32% (179, low grade- 58% (323, high grade- 10% (55; b. LSIL-H: (88 cases: ND 24% (21, low grade- 43% (38, high grade- 33% (29; c. ASCH: (38 cases: ND 32% (12, low grade- 37% (14, high grade- 31% (12; d. HSIL (109 cases: ND 5% (6, low grade 26% (28, high grade 69% (75. The patterns of cervical biopsy results in cases reported as LSIL-H were compared with that observed in cases with LSIL, ASC-H, and HSIL. 94% (32 of 34 of LSIL-H were positive for high risk (HR HPV, 1 was negative for HR HPV but positive for low risk (LR, and 1 LSIL-H was

  7. Idaho National Engineering and Environmental Laboratory institutional plan -- FY 2000--2004

    Energy Technology Data Exchange (ETDEWEB)

    Enge, R.S.

    1999-12-01

    In this first institutional plan prepared by Bechtel BWXT Idaho, LLC, for the Idaho National Engineering and Environmental Laboratory, the INEEL will focus its efforts on three strategic thrusts: (1) Environmental Management stewardship for DOE-EM, (2) Nuclear reactor technology for DOE-Nuclear Energy (NE), and (3) Energy R and D, demonstration, and deployment (initial focus on biofuels and chemicals from biomass). The first strategic thrust focuses on meeting DOE-EMs environmental cleanup and long-term stewardship needs in a manner that is safe, cost-effective, science-based, and approved by key stakeholders. The science base at the INEEL will be further used to address a grand challenge for the INEEL and the DOE complex--the development of a fundamental scientific understanding of the migration of subsurface contaminants. The second strategic thrust is directed at DOE-NEs needs for safe, economical, waste-minimized, and proliferation-resistant nuclear technologies. As NE lead laboratories, the INEEL and ANL will pursue specific priorities. The third strategic thrust focuses on DOE's needs for clean, efficient, and renewable energy technology. As an initial effort, the INEEL will enhance its capability in biofuels, bioprocessing, and biochemicals. The content of this institutional plan is designed to meet basic DOE requirements for content and structure and reflect the key INEEL strategic thrusts. Updates to this institutional plan will offer additional content and resource refinements.

  8. Environmental implications and applications of engineered nanoscale magnetite and its hybrid nanocomposites: A review of recent literature

    Science.gov (United States)

    This review focus on environmental implications and applications of engineered magnetite (Fe3O4) nanoparticles (MNPs) as a single phase or a component of a hybrid nanocomposite that take advantages of their superparamagnetism and high surface area. MNPs are synthesized via co-pre...

  9. Uso do ácido ascórbico no controle do escurecimento do pericarpo de lichia Use of ascorbic acid in the control of browning in the pericarp of lychees

    Directory of Open Access Journals (Sweden)

    Danieele Fabíola Pereira da Silva

    2010-06-01

    Full Text Available Um dos maiores problemas na pós-colheita da lichia é o escurecimento do pericarpo, o qual tem sido atribuído à degradação da antocianina. O objetivo do trabalho foi avaliar o efeito de diferentes doses de ácido ascórbico na prevenção do escurecimento do pericarpo e na manutenção da qualidade pós-colheita de lichia. Frutos de lichieira 'Bengal' com o pericarpo completamente vermelho foram imersos em solução com diferentes doses de ácido ascórbico (0; 5; 10; 15 e 30 mM, por 5 minutos. Após secagem à temperatura ambiente, foram acondicionados em bandejas de poliestireno, armazenados em câmara fria a 5 ± 1,2°C e 90 ± 5% de UR e avaliados a cada 4 dias, durante 12 dias. Observou-se que a perda de massa fresca foi maior nos frutos não tratados com ácido ascórbico. Independentemente da dose, o ácido ascórbico teve pouco efeito na retenção da cor vermelha do pericarpo de lichia. A atividade das enzimas polifenoloxidase e peroxidase no pericarpo foi maior com as menores doses de ácido ascórbico (0; 5 e 10 mM, entretanto observou-se escurecimento a partir do quarto dia no pericarpo dos frutos tratados com este ácido. O ácido ascórbico também não foi eficiente na manutenção da qualidade interna dos frutos.One of the biggest problems in postharvest of lychees is the pericarp browning, which has been attributed to anthocyanins degradation. The purpose of this work was to evaluate the effect of different doses of ascorbic acid to prevent pericarp browning and on the maintenance of postharvest quality of lychees. Fruits of 'Bengal' lychee with completely red pericarp were immersed in solution with different doses of ascorbic acid (0, 5, 10, 15 and 30 mM for 5 minutes. After dried, the fruits were packed in polystyrene trays, stored in cold chamber at 5 ± 1,2°C e 90 ± 5% de RH and evaluated every other 4 days for 12 days. It was observed that the loss of fresh weight was higher in non-treated with ascorbic acid

  10. Integrated Hydrologic Science and Environmental Engineering Observatory: CLEANER's Vision for the WATERS Network

    Science.gov (United States)

    Montgomery, J. L.; Minsker, B. S.; Schnoor, J.; Haas, C.; Bonner, J.; Driscoll, C.; Eschenbach, E.; Finholt, T.; Glass, J.; Harmon, T.; Johnson, J.; Krupnik, A.; Reible, D.; Sanderson, A.; Small, M.; van Briesen, J.

    2006-05-01

    With increasing population and urban development, societies grow more and more concerned over balancing the need to maintain adequate water supplies with that of ensuring the quality of surface and groundwater resources. For example, multiple stressors such as overfishing, runoff of nutrients from agricultural fields and confined animal feeding lots, and pathogens in urban stormwater can often overwhelm a single water body. Mitigating just one of these problems often depends on understanding how it relates to others and how stressors can vary in temporal and spatial scales. Researchers are now in a position to answer questions about multiscale, spatiotemporally distributed hydrologic and environmental phenomena through the use of remote and embedded networked sensing technologies. It is now possible for data streaming from sensor networks to be integrated by a rich cyberinfrastructure encompassing the innovative computing, visualization, and information archiving strategies needed to cope with the anticipated onslaught of data, and to turn that data around in the form of real-time water quantity and quality forecasting. Recognizing this potential, NSF awarded $2 million to a coalition of 12 institutions in July 2005 to establish the CLEANER Project Office (Collaborative Large-Scale Engineering Analysis Network for Environmental Research; http://cleaner.ncsa.uiuc.edu). Over the next two years the project office, in coordination with CUAHSI (Consortium of Universities for the Advancement of Hydrologic Science, Inc.; http://www.cuahsi.org), will work together to develop a plan for a WATer and Environmental Research Systems Network (WATERS Network), which is envisioned to be a collaborative scientific exploration and engineering analysis network, using high performance tools and infrastructure, to transform our scientific understanding of how water quantity, quality, and related earth system processes are affected by natural and human-induced changes to the environment

  11. Induction of osteogenic differentiation of adipose derived stem cells by microstructured nitinol actuator-mediated mechanical stress.

    Directory of Open Access Journals (Sweden)

    Sarah Strauß

    Full Text Available The development of large tissue engineered bone remains a challenge in vitro, therefore the use of hybrid-implants might offer a bridge between tissue engineering and dense metal or ceramic implants. Especially the combination of the pseudoelastic implant material Nitinol (NiTi with adipose derived stem cells (ASCs opens new opportunities, as ASCs are able to differentiate osteogenically and therefore enhance osseointegration of implants. Due to limited knowledge about the effects of NiTi-structures manufactured by selective laser melting (SLM on ASCs the study started with an evaluation of cytocompatibility followed by the investigation of the use of SLM-generated 3-dimensional NiTi-structures preseeded with ASCs as osteoimplant model. In this study we could demonstrate for the first time that osteogenic differentiation of ASCs can be induced by implant-mediated mechanical stimulation without support of osteogenic cell culture media. By use of an innovative implant design and synthesis via SLM-technique we achieved high rates of vital cells, proper osteogenic differentiation and mechanically loadable NiTi-scaffolds could be achieved.

  12. College of Engineering & Applied Science

    Science.gov (United States)

    Computational Mechanics Laboratory Environmental Engineering Laboratory Geotechnical Engineering Laboratory Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on Energy Doctoral Programs in Engineering Non-Degree Candidate Departments Biomedical Engineering

  13. Magnetic hyaluronic acid nanospheres via aqueous Diels-Alder chemistry to deliver dexamethasone for adipose tissue engineering.

    Science.gov (United States)

    Jia, Yang; Fan, Ming; Chen, Huinan; Miao, Yuting; Xing, Lian; Jiang, Bohong; Cheng, Qifan; Liu, Dongwei; Bao, Weikang; Qian, Bin; Wang, Jionglu; Xing, Xiaodong; Tan, Huaping; Ling, Zhonghua; Chen, Yong

    2015-11-15

    Biopolymer-based nanospheres have great potential in the field of drug delivery and tissue regenerative medicine. In this work, we present a flexible way to conjugate a magnetic hyaluronic acid (HA) nanosphere system that are capable of vectoring delivery of adipogenic factor, e.g. dexamethasone, for adipose tissue engineering. Conjugation of nanospheres was established by aqueous Diels-Alder chemistry between furan and maleimide of HA derivatives. Simultaneously, a furan functionalized dexamethasone peptide, GQPGK, was synthesized and covalently immobilized into the nanospheres. The magnetic HA nanospheres were fabricated by encapsulating super-paramagnetic iron oxide nanoparticles, which exhibited quick magnetic sensitivity. The aqueous Diels-Alder chemistry made nanospheres high binding efficiency of dexamethasone, and the vectoring delivery of dexamethasone could be easily controlled by a external magnetic field. The potential application of the magnetic HA nanospheres on vectoring delivery of adipogenic factor was confirmed by co-culture of human adipose-derived stem cells (ASCs). In vitro cytotoxicity tests demonstrated that incorporation of dexamethasone into magnetic HA nanospheres showed high efficiency to promote ASCs viabilities, in particular under a magnetic field, which suggested a promising future for adipose regeneration applications. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Modelling of Electrokinetic Processes in Civil and Environmental Engineering Applications

    DEFF Research Database (Denmark)

    Paz-Garcia, Juan Manuel; Johannesson, Björn; Ottosen, Lisbeth M.

    2011-01-01

    conditions are assumed between the aqueous species and the solid matrix for a set of feasible chemical equilibrium reactions defined for each specific application. A module for re-establishing the chemical equilibrium has been developed and included in the system for this purpose. Changes in the porosity......A mathematical model for the electrokinetic phenomena is described. Numerical simulations of different applications of electrokinetic techniques to the fields of civil and environmental engineering are included, showing the versatility and consistency of the model. The electrokinetics phenomena......-Nernst-Planck system of equations, accounting for ionic migration, chemical diffusion and advection is used for modeling the transport process. The advection term contributor is studied by including in the system the water transport through the porous media, mainly due to electroosmosis. The pore solution filling...

  15. Adsorption of Oxy-Anions in the Teaching Laboratory: An Experiment to Study a Fundamental Environmental Engineering Problem

    Science.gov (United States)

    D'Arcy, Mitch; Bullough, Florence; Moffat, Chris; Borgomeo, Edoardo; Teh, Micheal; Vilar, Ramon; Weiss, Dominik J.

    2014-01-01

    Synthesizing and testing bicomposite adsorbents for the removal of environmentally problematic oxy-anions is high on the agenda of research-led universities. Here we present a laboratory module successfully developed at Imperial College London that introduces the advanced undergraduate student in engineering (chemical, civil, earth) and science…

  16. The calculation and estimation of wastes generated by decommissioning of nuclear facilities. Tokai works and Ningyo-toge Environmental Engineering Center

    International Nuclear Information System (INIS)

    Ayame, Y.; Tanabe, T.; Takahashi, K.; Takeda, S.

    2001-07-01

    This investigation was conducted as a part of planning the low-level radioactive waste management program (LLW management program). The aim of this investigation was contributed to compile the radioactive waste database of JNC's LLW management program. All nuclear facilities of the Tokai works and Ningyo-toge Environmental Engineering Center were investigated in this work. The wastes generated by the decommissioning of each nuclear facility were classified into radioactive waste and others (exempt waste and non-radioactive waste), and the amount of the wastes was estimated. The estimated amounts of radioactive wastes generated by decommissioning of the nuclear facilities are as follows. (1) Tokai works: The amount of waste generated by decommissioning of nuclear facilities of the Tokai works is about 1,079,100 ton. The amount of radioactive waste is about 15,400 ton. The amount of exempt waste and non-radioactive waste is about 1,063,700 ton. (2) Ningyo-toge Environmental Engineering Center: The amount of waste generated by decommissioning of nuclear facilities of Ningyo-toge Environmental Engineering Center is about 112,500 ton. The amount of radioactive waste is about 7,800 ton. The amount of exempt waste and non-radioactive waste is about 104,700 ton. (author)

  17. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement

    International Nuclear Information System (INIS)

    1994-06-01

    Two types of projects in the spent nuclear fuel and environmental restoration and waste management activities at the Idaho National Engineering Laboratory (INEL) are described. These are: foreseeable proposed projects where some funding for preliminary planning and/or conceptual design may already be authorized, but detailed design or planning will not begin until the Department of Energy (DOE) has determined that the requirements of the National Environmental Policy Act process for the project have been completed; planned or ongoing projects not yet completed but whose National Environmental Policy Act documentation is already completed or is expected to be completed before the Record of Decision for this Envirorunental Impact Statement (EIS) is issued. The section on project summaries describe the projects (both foreseeable proposed and ongoing).They provide specific information necessary to analyze the environmental impacts of these projects. Chapter 3 describes which alternative(s) each project supports. Summaries are included for (a) spent nuclear fuel projects, (b) environmental remediation projects, (c) the decontamination and decommissioning of surplus INEL facilities, (d) the construction, upgrade, or replacement of existing waste management facilities, (e) infrastructure projects supporting waste management activities, and (f) research and development projects supporting waste management activities

  18. Development of an Engineering Soil Database

    Science.gov (United States)

    2017-12-27

    ER D C TR 1 7- 15 Rapid Airfield Damage Recovery (RADR) Program Development of an Engineering Soil Database En gi ne er R es ea rc...distribution is unlimited. The US Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental...challenges. ERDC develops innovative solutions in civil and military engineering , geospatial sciences, water resources, and environmental sciences

  19. Modification of Displacement Coefficient Method in Estimation of Target Displacement for Regular Concrete Bridges Based on ASCE 41-06 Standard

    Directory of Open Access Journals (Sweden)

    Seyed Bahram Beheshti-Aval

    2015-06-01

    Full Text Available Displacement Coefficient Method (DCM stipulated in the ASCE 41-06 standard is becoming the preferred method for seismic rehabilitation of buildings in many high-seismic-hazard countries. Applications of the method for non-building constructions such as bridges are beyond the scope of this standard. Thus its application to this kind of structure should be approached with care. Target displacement has reasonable accuracy for buildings with strong columns and weak beams, where there is the development of plastic hinges. Due to high stiffness and strength of the deck relative to the piers in most bridges, this mechanism does not occur, and it is necessary to evaluate the accuracy of DCM for such structures. In this research, an attempt is made to evaluate the credibility of DCM in the ASCE/SEI 41-06 standard for estimating target drifts in concrete regular bridges under strong ground motions. To apply the extension of the method to bridge structures, the definition of new correction factor CB, which should be multiplied to previous coefficients, is required. This novel coefficient can improve the accuracy of the mentioned method in accessing seismic displacement demands. The coefficient is presented for soil types A to D based on NEHRP soil classification. The validity of the modified DCM is examined for several bridges with use of nonlinear dynamic analysis. Good correlation is found between both procedures.

  20. Pedagogic project of the Environmental Engineering Course of UNIPINHAL: structure, curricular emphasis and approaches

    OpenAIRE

    Maurício Salvetti; Marcelo Della Mura Jannini; Maria Eugenia Garcia Porto; Celso Henrique Zuppi da Conceição; Maristela Della Libera Reis Piccinini; Marta Wilk Donida; Ana Claudia Camargo Lima Tresmondi; Rogéria Maria Alves de Almeida; Nirlei Maria Oliveira; André Luis Paradela; Carlos Antonio Centurion Maciel; Gilberto José Hussar; Fabio Augusto Gomes Vieira Reis; Gerson Araujo de Medeiros; Mônica Luri Giboshi

    2006-01-01

    The courses of environmental engineering have increasingly become more common in Brazil. In spite of the common legislation that defines the subjects of basic, professional and specific graduation, there has been a variation in the focus given in the list of subjects of these courses, which have been strongly influenced by the vocation of the Institution of Undergraduate Teaching (IES). The objective of this essay is to present the structure, the curricular emphasis and the approaches used by...

  1. LCA as an environmental technology development performance indicator of engineered nano-materials and their application in polymers

    DEFF Research Database (Denmark)

    Miseljic, Mirko; Olsen, Stig Irving; Hauschild, Michael Zwicky

    Engineered nano‐material (ENM) application in products has in recent years developed to an important market segment but with rising environmental concerns, as the environmental life cycle impacts, especially toxicity of nanoparticles, are not assessed. Life cycle assessment (LCA) is a holistic tool...... project is aimed to be holistic and thereby include the entire life cycle of the nano‐polymer products and not be like the current frequently applied nano‐material LCA case study approaches where the life cycle is reduced and system boundaries substantially limited. In order to perform accurate...

  2. Automated Method to Develop a Clark Synthetic Unit Hydrograph within ArcGIS

    Science.gov (United States)

    2015-08-01

    the totaltime.asc raster to determine how long the rain in each cell takes to get to the outlet. This second method takes a Lagrangian approach to...occurred between 15 August and 15 September 2011 when multiple large rain events occurred over the study area. This time period will serve to show how...storm sewers . ASCE (American Society of Civil Engineers) Manual on Engineering Practice No. 37 and WPCF (Water Pollution Control Federation) Manual

  3. ONR K-16 Engineering Pipeline: Engineering Success in STEM Project

    Science.gov (United States)

    2016-10-19

    Algebra I Industrial and Engineering - AP Statistics - Algebra II - Precalculus / Technology Core Science: Trigonometry - Calculus - AP...AP Environmental Sequence Science - Algebra II Grade 10 - Precalculus / Engineering Program Trigonometry TIU5810 of Study Cluster -Calculus

  4. Environmental engineering of navigation infrastructure: a survey of existing practices, challenges, and potential opportunities.

    Science.gov (United States)

    Fredette, Thomas J; Foran, Christy M; Brasfield, Sandra M; Suedel, Burton C

    2012-01-01

    Navigation infrastructure such as channels, jetties, river training structures, and lock-and-dam facilities are primary components of a safe and efficient water transportation system. Planning for such infrastructure has until recently involved efforts to minimize impacts on the environment through a standardized environmental assessment process. More recently, consistent with environmental sustainability concepts, planners have begun to consider how such projects can also be constructed with environmental enhancements. This study examined the existing institutional conditions within the US Army Corps of Engineers and cooperating federal agencies relative to incorporating environmental enhancements into navigation infrastructure projects. The study sought to (1) investigate institutional attitudes towards the environmental enhancement of navigation infrastructure (EENI) concept, (2) identify potential impediments to implementation and solutions to such impediments, (3) identify existing navigation projects designed with the express intent of enhancing environmental benefit in addition to the primary project purpose, (4) identify innovative ideas for increasing environmental benefits for navigation projects, (5) identify needs for additional technical information or research, and (6) identify laws, regulations, and policies that both support and hinder such design features. The principal investigation tool was an Internet-based survey with 53 questions. The survey captured a wide range of perspectives on the EENI concept including ideas, concerns, research needs, and relevant laws and policies. Study recommendations included further promotion of the concept of EENI to planners and designers, documentation of existing projects, initiation of pilot studies on some of the innovative ideas provided through the survey, and development of national goals and interagency agreements to facilitate implementation. Copyright © 2011 SETAC.

  5. Hydrologic Engineering Center River Analysis System (HEC-RAS) Water Temperature Models Developed for the Missouri River Recovery Management Plan and Environmental Impact Statement

    Science.gov (United States)

    2017-09-18

    ER D C/ EL T R- 17 -1 8 Missouri River Recovery Program (MRRP) Hydrologic Engineering Center-River Analysis System (HEC-RAS) Water...Zhonglong Zhang and Billy E. Johnson September 2017 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research...and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and

  6. Budget-impact model for colonoscopy cost calculation and comparison between 2 litre PEG+ASC and sodium picosulphate with magnesium citrate or sodium phosphate oral bowel cleansing agents.

    Science.gov (United States)

    Gruss, H-J; Cockett, A; Leicester, R J

    2012-01-01

    With the availability of several bowel cleansing agents, physicians and hospitals performing colonoscopies will often base their choice of cleansing agent purely on acquisition cost. Therefore, an easy to use budget impact model has been developed and established as a tool to compare total colon preparation costs between different established bowel cleansing agents. The model was programmed in Excel and designed as a questionnaire evaluating information on treatment costs for a range of established bowel cleansing products. The sum of costs is based on National Health Service reference costs for bowel cleansing products. Estimations are made for savings achievable when using a 2-litre polyethylene glycol with ascorbate components solution (PEG+ASC) in place of other bowel cleansing solutions. Test data were entered into the model to confirm validity and sensitivity. The model was then applied to a set of audit cost data from a major hospital colonoscopy unit in the UK. Descriptive analysis of the test data showed that the main cost drivers in the colonoscopy process are the procedure costs and costs for bed days rather than drug acquisition costs, irrespective of the cleansing agent. Audit data from a colonoscopy unit in the UK confirmed the finding with a saving of £107,000 per year in favour of PEG+ASC when compared to sodium picosulphate with magnesium citrate solution (NaPic+MgCit). For every patient group the model calculated overall cost savings. This was irrespective of the higher drug expenditure associated with the use of PEG+ASC for bowel preparation. Savings were mainly realized through reduced costs for repeat colonoscopy procedures and associated costs, such as inpatient length of stay. The budget impact model demonstrated that the primary cost driver was the procedure cost for colonoscopy. Savings can be realized through the use of PEG+ASC despite higher drug acquisition costs relative to the comparator products. From a global hospital funding

  7. Development of a Study Module on and Pedagogical Approaches to Industrial Environmental Engineering and Sustainability in Mozambique

    Science.gov (United States)

    Husgafvel, Roope; Martikka, Mikko; Egas, Andrade; Ribiero, Natasha; Dahl, Olli

    2017-01-01

    Addressing the sustainability challenges in the forest sector in Mozambique requires capacity building for higher education and training of new skilled expert and future decision-makers. Our approach was to develop a study module on and pedagogical approaches to industrial environmental engineering and sustainability. The idea was to develop a…

  8. Engineering students' sustainability approaches

    Science.gov (United States)

    Haase, S.

    2014-05-01

    Sustainability issues are increasingly important in engineering work all over the world. This article explores systematic differences in self-assessed competencies, interests, importance, engagement and practices of newly enrolled engineering students in Denmark in relation to environmental and non-environmental sustainability issues. The empirical base of the article is a nation-wide, web-based survey sent to all newly enrolled engineering students in Denmark commencing their education in the fall term 2010. The response rate was 46%. The survey focused on a variety of different aspects of what can be conceived as sustainability. By means of cluster analysis, three engineering student approaches to sustainability are identified and described. The article provides knowledge on the different prerequisites of engineering students in relation to the role of sustainability in engineering. This information is important input to educators trying to target new engineering students and contribute to the provision of engineers equipped to meet sustainability challenges.

  9. Testing of Environmental Satellite Bus-Instrument Interfaces Using Engineering Models

    Science.gov (United States)

    Gagnier, Donald; Hayner, Rick; Nosek, Thomas; Roza, Michael; Hendershot, James E.; Razzaghi, Andrea I.

    2004-01-01

    This paper discusses the formulation and execution of a laboratory test of the electrical interfaces between multiple atmospheric scientific instruments and the spacecraft bus that carries them. The testing, performed in 2002, used engineering models of the instruments and the Aura spacecraft bus electronics. Aura is one of NASA s Earth Observatory System missions. The test was designed to evaluate the complex interfaces in the command and data handling subsystems prior to integration of the complete flight instruments on the spacecraft. A problem discovered during the flight integration phase of the observatory can cause significant cost and schedule impacts. The tests successfully revealed problems and led to their resolution before the full-up integration phase, saving significant cost and schedule. This approach could be beneficial for future environmental satellite programs involving the integration of multiple, complex scientific instruments onto a spacecraft bus.

  10. 1995 annual epidemiologic surveillance report for Idaho National Engineering and Environmental Laboratory

    International Nuclear Information System (INIS)

    1995-01-01

    The US Department of Energy's (DOE) conduct of epidemiologic surveillance provides an early warning system for health problems among workers. This program monitors illnesses and health conditions that result in an absence of five or more consecutive workdays, occupational injuries and illnesses, and disabilities and deaths among current workers. This report summarizes epidemiologic surveillance data collected from the Idaho National Engineering and Environmental Laboratory (INEEL) from January 1, 1995 through December 31, 1995. The data were collected by a coordinator at INEEL and submitted to the Epidemiologic Surveillance Data Center, located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out

  11. 1995 annual epidemiologic surveillance report for Idaho National Engineering and Environmental Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The US Department of Energy's (DOE) conduct of epidemiologic surveillance provides an early warning system for health problems among workers. This program monitors illnesses and health conditions that result in an absence of five or more consecutive workdays, occupational injuries and illnesses, and disabilities and deaths among current workers. This report summarizes epidemiologic surveillance data collected from the Idaho National Engineering and Environmental Laboratory (INEEL) from January 1, 1995 through December 31, 1995. The data were collected by a coordinator at INEEL and submitted to the Epidemiologic Surveillance Data Center, located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out.

  12. Air Emission Inventory for the Idaho National Engineering and Environmental Laboratory - Calendar Year 1999 Emission Report

    Energy Technology Data Exchange (ETDEWEB)

    Zohner, S.K.

    2000-05-30

    This report presents the 1999 calendar year update of the Air Emission Inventory for the Idaho National Engineering and Environmental Laboratory (INEEL). The INEEL Air Emission Inventory documents sources and emissions of nonradionuclide pollutants from operations at the INEEL. The report describes the emission inventory process and all of the sources at the INEEL, and provides nonradionuclide emissions estimates for stationary sources.

  13. Air Emission Inventory for the Idaho National Engineering and Environmental Laboratory - Calendar Year 1998 Emissions Report

    Energy Technology Data Exchange (ETDEWEB)

    S. K. Zohner

    1999-10-01

    This report presents the 1998 calendar year update of the Air Emission Inventory for the Idaho National Engineering and Environmental Laboratory (INEEL). The INEEL Air Emission Inventory documents sources and emissions of nonradionuclide pollutants from operations at the INEEL. The report describes the emission inventory process and all of the sources at the INEEL, and provides nonradiological emissions estimates for stationary sources.

  14. The Role of Gender in Students' Ratings of Teaching Quality in Computer Science and Environmental Engineering

    Science.gov (United States)

    Price, Linda; Svensson, Ingrid; Borell, Jonas; Richardson, John T. E.

    2017-01-01

    Students' ratings of teaching quality on course units in a computer science program and an environmental engineering program at a large Swedish university were obtained using the Course Experience Questionnaire; 8888 sets of ratings were obtained from men and 4280 sets were obtained from women over ten academic years. These student ratings from…

  15. Engineered nano materials and the U.S. Environmental Protection Agency: Research at the Western Ecology Division in Oregon, USA

    Science.gov (United States)

    Engineered nanoparticles represent a unique hazard to human health and the environment because their inherent characteristics differ significantly from commonly used chemicals and bulk forms of materials. The U.S. Environmental Protection Agency (EPA) is responsible for protecti...

  16. Idaho National Engineering and Environmental Laboratory Site Environmental Report for Calendar Year 1998

    Energy Technology Data Exchange (ETDEWEB)

    T. R. Saffle; R. G. Mitchell; R. B. Evans; D. B. Martin

    2000-07-01

    The results of the various monitoring programs for 1998 indicated that radioactivity from the DOE's Idaho National Engineering and Environmental Laboratory (INEEL) operations could generally not be distinguished from worldwide fallout and natural radioactivity in the region surrounding the INEEL. Although some radioactive materials were discharged during INEEL operations, concentrations in the offsite environment and doses to the surrounding population were far less than state of Idaho and federal health protection guidelines. Gross alpha and gross beta measurements, used as a screening technique for air filters, were investigated by making statistical comparisons between onsite or boundary location concentrations and the distant community group concentrations. Gross alpha activities were generally higher at distant locations than at boundary and onsite locations. Air samples were also analyzed for specific radionuclides. Some human-made radionuclides were detected at offsite locations, but most were near the minimum detectable concentration and their presence was attributable to natural sources, worldwide fallout, and statistical variations in the analytical results rather than to INEEL operations. Low concentrations of 137Cs were found in muscle tissue and liver of some game animals and sheep. These levels were mostly consistent with background concentrations measured in animals sampled onsite and offsite in recent years. Ionizing radiation measured simultaneously at the INEEL boundary and distant locations using environmental dosimeters were similar and showed only background levels. The maximum potential population dose from submersion, ingestion, inhalation, and deposition to the approximately 121,500 people residing within an 80-km (50-mi) radius from the geographical center of the INEEL was estimated to be 0.08 person-rem (8 x 10-4 person-Sv) using the MDIFF air dispersion model. This population dose is less than 0.0002 percent of the estimated 43,7 00

  17. Assessment of Environmental Factors of Geology on Waste and Engineering Barriers for Waste Storage Near Surface

    International Nuclear Information System (INIS)

    Arimuladi SP

    2007-01-01

    Geological environment factors include features and processes occurring within that spatial and temporal (post-closure) domain whose principal effect is to determine the evolution of the physical, chemical, biological and human conditions of the domain that are relevant to estimating the release and migration of radionuclide and consequent exposure to man. Hardness of radioactive waste and engineer barrier can be decrease by environmental factors. Disposal system domain geological environment factors is a category in the International FEP list and is divided into sub-categories. There are 13 sub-factors of geological environment, 12 sub-factors influence hardness of radioactive waste and engineer barrier, thermal processes and conditions in geosphere can be excluded. (author)

  18. An approach for environmental risk assessment of engineered nanomaterials using Analytical Hierarchy Process (AHP) and fuzzy inference rules

    NARCIS (Netherlands)

    Topuz, E.; van Gestel, C.A.M.

    2016-01-01

    The usage of Engineered Nanoparticles (ENPs) in consumer products is relatively new and there is a need to conduct environmental risk assessment (ERA) to evaluate their impacts on the environment. However, alternative approaches are required for ERA of ENPs because of the huge gap in data and

  19. Environmental Protection Versus Foundry Engineering Practice

    OpenAIRE

    Maj M.; Werrtz J.; Piekło J.

    2017-01-01

    • Theory and practice of environmental protection in the case of foundries in Europe and Asia • Experience resulting from the cooperation with the foundries in a few European countries, China and India • Phenomena and factors affecting the pollution of the natural environment and the implementation of measures aiming at the environmental protection. Every specialist dealing with foundry processes and their impact on environmental pollution must have encountered in their professional careers n...

  20. Environmental surveillance for EG ampersand G Idaho Waste Management facilities at the Idaho National Engineering Laboratory. 1993 annual report

    International Nuclear Information System (INIS)

    Wilhelmsen, R.N.; Wright, K.C.; McBride, D.W.; Borsella, B.W.

    1994-08-01

    This report describes calendar year 1993 environmental surveillance activities of Environmental Monitoring of EG ampersand G Idaho, Inc., performed at EG ampersand G Idaho operated Waste Management facilities at the Idaho National Engineering Laboratory (INEL). The major facilities monitored include the Radioactive Waste Management Complex, the Waste Experimental Reduction Facility, the Mixed Waste Storage Facility, and two surplus facilities. Included are results of the sampling performed by the Radiological and Environmental Sciences Laboratory and the United States Geological Survey. The primary purposes of monitoring are to evaluate environmental conditions, to provide and interpret data, to ensure compliance with applicable regulations or standards, and to ensure protection of human health and the environment. This report compares 1993 environmental surveillance data with US Department of Energy derived concentration guides and with data from previous years

  1. Annual report -- 1992: Environmental surveillance for EG ampersand G Idaho Waste Management Facilities at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Wilhelmsen, R.N.; Wright, K.C.; McBride, D.W.

    1993-08-01

    This report describes the 1992 environmental surveillance activities of the Environmental Monitoring Unit of EG ampersand G Idaho, Inc., at EG ampersand G Idaho-operated Waste Management facilities at the Idaho National Engineering Laboratory (INEL). The major facilities monitored include the Radioactive Waste Management Complex, the Waste Experimental Reduction Facility, the Mixed Waste Storage Facility, and two surplus facilities. Included are some results of the sampling performed by the Radiological and Environmental Sciences Laboratory and the United States Geological Survey. The primary purposes of monitoring are to evaluate environmental conditions, to provide and interpret data, to ensure compliance with applicable regulations or standards, and to ensure protection of human health and the environment. This report compares 1992 environmental surveillance data with DOE derived concentration guides, and with data from previous years

  2. Introduction of Microbial Biopolymers in Soil Treatment for Future Environmentally-Friendly and Sustainable Geotechnical Engineering

    Directory of Open Access Journals (Sweden)

    Ilhan Chang

    2016-03-01

    Full Text Available Soil treatment and improvement is commonly performed in the field of geotechnical engineering. Methods and materials to achieve this such as soil stabilization and mixing with cementitious binders have been utilized in engineered soil applications since the beginning of human civilization. Demand for environment-friendly and sustainable alternatives is currently rising. Since cement, the most commonly applied and effective soil treatment material, is responsible for heavy greenhouse gas emissions, alternatives such as geosynthetics, chemical polymers, geopolymers, microbial induction, and biopolymers are being actively studied. This study provides an overall review of the recent applications of biopolymers in geotechnical engineering. Biopolymers are microbially induced polymers that are high-tensile, innocuous, and eco-friendly. Soil–biopolymer interactions and related soil strengthening mechanisms are discussed in the context of recent experimental and microscopic studies. In addition, the economic feasibility of biopolymer implementation in the field is analyzed in comparison to ordinary cement, from environmental perspectives. Findings from this study demonstrate that biopolymers have strong potential to replace cement as a soil treatment material within the context of environment-friendly construction and development. Moreover, continuing research is suggested to ensure performance in terms of practical implementation, reliability, and durability of in situ biopolymer applications for geotechnical engineering purposes.

  3. Public health engineering education in India: current scenario, opportunities and challenges.

    Science.gov (United States)

    Hussain, Mohammad Akhtar; Sharma, Kavya; Zodpey, Sanjay

    2011-01-01

    Public health engineering can play an important and significant role in solving environmental health issues. In order to confront public health challenges emerging out of environmental problems we need adequately trained public health engineers / environmental engineers. Considering the current burden of disease attributable to environmental factors and expansion in scope of applications of public health / environmental engineering science, it is essential to understand the present scenario of teaching, training and capacity building programs in these areas. Against this background the present research was carried out to know the current teaching and training programs in public health engineering and related disciplines in India and to understand the potential opportunities and challenges available. A systematic, predefined approach was used to collect and assemble the data related to various teaching and training programs in public health engineering / environmental engineering in India. Public health engineering / environmental engineering education and training in the country is mainly offered through engineering institutions, as pre-service and in-service training. Pre-service programs include diploma, degree (graduate) and post-graduate courses affiliated to various state technical boards, institutes and universities, whereas in-service training is mainly provided by Government of India recognized engineering and public health training institutes. Though trainees of these programs acquire skills related to engineering sciences, they significantly lack in public health skills. The teaching and training of public health engineering / environmental engineering is limited as a part of public health programs (MD Community Medicine, MPH, DPH) in India. There is need for developing teaching and training of public health engineering or environmental engineering as an interdisciplinary subject. Public health institutes can play an important and significant role in this

  4. Spirulina platensis Improves Mitochondrial Function Impaired by Elevated Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells (ASCs) and Intestinal Epithelial Cells (IECs), and Enhances Insulin Sensitivity in Equine Metabolic Syndrome (EMS) Horses.

    Science.gov (United States)

    Nawrocka, Daria; Kornicka, Katarzyna; Śmieszek, Agnieszka; Marycz, Krzysztof

    2017-08-03

    Equine Metabolic Syndrome (EMS) is a steadily growing life-threatening endocrine disorder linked to insulin resistance, oxidative stress, and systemic inflammation. Inflammatory microenvironment of adipose tissue constitutes the direct tissue milieu for various cell populations, including adipose-derived mesenchymal stromal cells (ASCs), widely considered as a potential therapeutic cell source in the course of the treatment of metabolic disorders. Moreover, elevated oxidative stress induces inflammation in intestinal epithelial cells (IECs)-the first-line cells exposed to dietary compounds. In the conducted research, we showed that in vitro application of Spirulina platensis contributes to the restoration of ASCs' and IECs' morphology and function through the reduction of cellular oxidative stress and inflammation. Enhanced viability, suppressed senescence, and improved proliferation of ASCs and IECs isolated from metabolic syndrome-affected individuals were evident following exposition to Spirulina. A protective effect of the investigated extract against mitochondrial dysfunction and degeneration was also observed. Moreover, our data demonstrate that Spirulina extract effectively suppressed LPS-induced inflammatory responses in macrophages. In vivo studies showed that horses fed with a diet based on Spirulina platensis supplementation lost weight and their insulin sensitivity improved. Thus, our results indicate the engagement of Spirulina platensis nourishing as an interesting alternative approach for supporting the conventional treatment of equine metabolic syndrome.

  5. Implementing of action plans for risk communication on the uranium mining sites remedy at Ningyo-toge Environmental Engineering Center (2) (Contract research)

    International Nuclear Information System (INIS)

    Yabuta, Naohiro; Kawai, Jun; Hikawa, Tamae; Tokizawa, Takayuki; Sato, Kazuhiko; Koga, Osamu

    2008-11-01

    On the closure of uranium mine site at Ningyo-Toge Environmental Engineering Center Japan Atomic Energy Agency, the action plans for risk communication with residence and local governments were developed and implemented. Under a practical program of the risk communication, an ethnographical research on Ningyo-Toge Environmental Engineering Center has been conducted by local high school students. The research was focused on several social groups such as engineers at the Center and residents around Ningyo-Toge and described their circumstances from the past to the present, since the discovery of the uranium outcrop 1955. In the second year of the program, the results of the research were presented at symposium and the students had opportunities to exchange their views with others from different high schools that held in similar programs. Through those activities, the importance of the program was rediscovered and some new issues were also identified. (author)

  6. Addressing the complexity of water chemistry in environmental fate modeling for engineered nanoparticles.

    Science.gov (United States)

    Sani-Kast, Nicole; Scheringer, Martin; Slomberg, Danielle; Labille, Jérôme; Praetorius, Antonia; Ollivier, Patrick; Hungerbühler, Konrad

    2015-12-01

    Engineered nanoparticle (ENP) fate models developed to date - aimed at predicting ENP concentration in the aqueous environment - have limited applicability because they employ constant environmental conditions along the modeled system or a highly specific environmental representation; both approaches do not show the effects of spatial and/or temporal variability. To address this conceptual gap, we developed a novel modeling strategy that: 1) incorporates spatial variability in environmental conditions in an existing ENP fate model; and 2) analyzes the effect of a wide range of randomly sampled environmental conditions (representing variations in water chemistry). This approach was employed to investigate the transport of nano-TiO2 in the Lower Rhône River (France) under numerous sets of environmental conditions. The predicted spatial concentration profiles of nano-TiO2 were then grouped according to their similarity by using cluster analysis. The analysis resulted in a small number of clusters representing groups of spatial concentration profiles. All clusters show nano-TiO2 accumulation in the sediment layer, supporting results from previous studies. Analysis of the characteristic features of each cluster demonstrated a strong association between the water conditions in regions close to the ENP emission source and the cluster membership of the corresponding spatial concentration profiles. In particular, water compositions favoring heteroaggregation between the ENPs and suspended particulate matter resulted in clusters of low variability. These conditions are, therefore, reliable predictors of the eventual fate of the modeled ENPs. The conclusions from this study are also valid for ENP fate in other large river systems. Our results, therefore, shift the focus of future modeling and experimental research of ENP environmental fate to the water characteristic in regions near the expected ENP emission sources. Under conditions favoring heteroaggregation in these

  7. Support for the Symposium on the Application of Geophysics to Environmental and Engineering Problems, 2012-2014

    Science.gov (United States)

    2014-07-02

    or to purchase EEGS merchandise , books, past SAGEEP Proceedings, copies of the Journal of Environmental & Engineering Geophysics, and FastTIMES...utilities. GSSI, Inc. GSSI will demonstrate our very popular UtilityScan DF (Dual-Frequency). The UtilityScan DF features a 300 and 800 MHz digital ...word processors, and image file collections. Case studies will include: (1) Creating digital geologic maps with 3-D symbols, emergent cross

  8. Source-to-sink sediment transfers, environmental engineering and hazard mitigation in the steep Var River catchment, French Riviera, southeastern France

    Science.gov (United States)

    Anthony, Edward J.; Julian, Maurice

    1999-12-01

    Steep coastal margins are potentially subject to mass wasting processes involving notable landslide activity and sediment evacuation downstream by steep-gradient streams. Sediment transfer from short source-to-sink segments, coupled with mountain hydrological regimes, regulate patterns of river channel aggradation and coastal sediment supply in such geomorphic settings. On the steep French Riviera margin, sediment transfers from existing landslides or from various minor mass wasting processes to stream channels may result following bursts of heavy, concentrated rainfall. High-magnitude flooding and massive sediment transport downstream are generally related to unpredictable extreme rainfalls. Both mass movements and channel sediment storage pose serious hazards to downvalley settlements and infrastructure. A consideration of channel sediment storage patterns in the Var River catchment, the most important catchment in this area, highlights two important shortcomings relative to environmental engineering and hazard mitigation practices. In the first place, the appreciation of geomorphic processes is rather poor. This is illustrated by the undersized nature of engineering works constructed to mitigate hazards in the upstream bedload-dominated channels, and by the unforeseen effects that ten rock dams, constructed in the early 1970s, have had on downstream and coastal sediment storage and on sediment dispersal patterns and, consequently, valley flooding. Secondly, planners and environmental engineers have lacked foresight in valley and coastal management issues on this steep setting, notably as regards the reclaimed areas of the lower Var channel and delta liable to flooding. Urbanization and transport and environmental engineering works have progressively affected patterns of storage and transport of fine-grained sediments in the lower Var channel and delta. Meanwhile the problems raised by these changes have not been adequately addressed in terms of scientific

  9. Cinética de la degradación del ácido ascórbico en jugo de parchita

    OpenAIRE

    Páez, Gisela; Freay, Jenny; Moreno, Mónica; Mármol, Zulay; Araujo, Karelen; Rincón, Marisela

    2008-01-01

    Se evaluó la cinética de la degradación del ácido ascórbico en el jugo de parchita maracuyá (Passiflora edulis f. flavicarpa) fresco y pasteurizado a diferentes temperaturas de almacenamiento (0 ºC, 10 ºC, 25 ºC, 40 ºC, 60 ºC).El jugo se caracterizó en términos de pH, acidez titulable,sólidos solubles totales, relación grados Brix acidez y azucares totales. Las muestras de jugo fresco y pasteurizado se almacenaron a temperaturas de 0 ºC y 10 ºC durante un periodo de 60 y 15 días respectivamen...

  10. In vitro dosimetry modeling will be a critical step toward efficient assessment of engineered nanomaterials for environmental health and safety

    Science.gov (United States)

    Presentation Description: The development and application of engineered nanomaterials (ENM) into commercial and consumer products is far outpacing the ability of traditional approaches to evaluate the potential implications for environmental health and safety. This problem recen...

  11. Polyurethane/Polylactide-Blend Films Doped with Zinc Ions for the Growth and Expansion of Human Olfactory Ensheathing Cells (OECs and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs for Regenerative Medicine Applications

    Directory of Open Access Journals (Sweden)

    Krzysztof Marycz

    2016-04-01

    Full Text Available Polymeric biomaterials based on polyurethane and polylactide blends are promising candidates for regenerative medicine applications as biocompatible, bioresorbable carriers. In current research we showed that 80/20 polyurethane/polylactide blends (PU/PLDL with confirmed biological properties in vitro may be further improved by the addition of ZnO nanoparticles for the delivery of bioactive zinc oxide for cells. The PU/PLDL blends were doped with different concentrations of ZnO (0.001%, 0.01%, 0.05% and undertaken for in vitro biological evaluation using human adipose stromal stem cells (ASCs and olfactory ensheathing cells (OECs. The addition of 0.001% of ZnO to the biomaterials positively influenced the morphology, proliferation, and phenotype of cells cultured on the scaffolds. Moreover, the analysis of oxidative stress markers revealed that 0.001% of ZnO added to the material decreased the stress level in both cell lines. In addition, the levels of neural-specific genes were upregulated in OECs when cultured on sample 0.001 ZnO, while the apoptosis-related genes were downregulated in OECs and ASCs in the same group. Therefore, we showed that PU/PLDL blends doped with 0.001% of ZnO exert beneficial influence on ASCs and OECs in vitro and they may be considered for future applications in the field of regenerative medicine.

  12. Efeito do resveratrol e do ácido ascórbico na criopreservação de sêmen humano

    OpenAIRE

    Garcez, Márcia Esteves Silva

    2011-01-01

    A criopreservação de sêmen humano é de grande importância para a medicina reprodutiva, porém esse processo pode causar danos ao espermatozóide devido, entre outros aspectos, à produção de espécies reativas de oxigênio, as quais podem lesar as biomoléculas. Tanto o resveratrol quanto o ácido ascórbico são compostos com reconhecida capacidade antioxidante, porém ainda pouco estudados em relação à prevenção de criodanos em espermatozóides humanos. Desta forma, o objetivo deste est...

  13. Adoção de Cidadãos Presos e Formação de Professores para a Prisão: Ações de Fraternidade Política e Direitos, aproximando a extensão universitária da ASCES e da UFPE no agreste pernambucano. Adoption of inmates and teacher training for prison: Actions of political fraternity and human rights approaching university extension to ASCES and UFPE in the rural area of Pernambuco state, Brazil

    Directory of Open Access Journals (Sweden)

    Jordão, Maria Perpétua S. D.

    2014-08-01

    Full Text Available Este artigo trata de analisar como dois projetos extensionistas – Adoção Jurídica de Cidadãos Presos (ASCES e Formação de Professores para o Sistema Penitenciário (UFPE – possibilitam desde 2001 (ASCES e 2009 (UFPE ações articuladas de cidadania e direitos humanos em uma unidade prisional do agreste de Pernambuco, Brasil. O trabalho foi articulado a partir da participação de professores da ASCES em Grupo de Pesquisa da UFPE-CNPq e da percepção de como a integração das atividades institucionais poderiam melhorar os resultados e incluir um número maior de docentes, discentes e beneficiados, os reclusos e educadores do Sistema Penitenciário. As ações são realizadas quinzenalmente na unidade prisional, envolvendo ampla participação da sociedade civil; os trabalhos são apresentados em forma de encontros de formação com os professores, palestras e debates com os detentos e atividades mediadas por elementos lúdicos: imagens, fotografias, filmes, documentários, músicas, poesias. Os estudantes das duas instituições se integram sem competição, os professores recebem formação continuada e as atividades lúdicas com os detentos quebram a rotina da prisão e estimulam os detentos a se manter nas salas de aula, reduzindo a evasão. A atividade é utilizada como carga horária de estágio para os alunos da ASCES e como atividades complementares para os estudantes de Pedagogia, e permitem às duas instituições contribuir para a melhoria da qualidade de ensino na prisão. Essa atividade também estimula o convívio de estudantes de instituições distintas, incluindo estudantes de instituições que, inclusive, não são parceiras dos projetos, atraindo a participação de muitos voluntários e ex-alunos da ASCES e da Faculdade de Filosofia, Ciências e Letras de Caruaru (FAFICA. A fraternidade política aparece como referencial teórico no trabalho com os docentes e no estímulo às relações entre os sujeitos envolvidos

  14. Environmental effects of engineered nanomaterials

    DEFF Research Database (Denmark)

    Lützhøft, Hans-Christian Holten; Hartmann, Nanna B.; Brinch, Anna

    This report presents ecotoxicological data and Predicted No-Effect Concentrations (PNECs) for nine selected nanomaterials which are considered to be environmentally relevant due to high usage or how they are used. These data will together with data from other reports/projects be used in an overall...... assessment of the environmental risk of nanomaterials in Denmark. The nine investigated nanomaterials are: Titanium Dioxide, Zinc Oxide, Silver, Carbon Nanotubes, Copper Oxide, Nano Zero Valent Iron, Cerium Dioxide, Quantum Dots and Carbon Black. To support the assessment of the data found in the peer...

  15. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement

    International Nuclear Information System (INIS)

    1994-06-01

    The US Department of Energy (DOE) is engaged in two related decision making processes concerning: (1) the transportation, receipt, processing, and storage of spent nuclear fuel (SNF) at the DOE Idaho National Engineering Laboratory (INEL) which will focus on the next 10 years; and (2) programmatic decisions on future spent nuclear fuel management which will emphasize the next 40 years. DOE is analyzing the environmental consequences of these spent nuclear fuel management actions in this two-volume Environmental Impact Statement (EIS). Volume 1 supports broad programmatic decisions that will have applicability across the DOE complex and describes in detail the purpose and need for this DOE action. Volume 2 is specific to actions at the INEL. This document, which limits its discussion to the Savannah River Site (SRS) spent nuclear fuel management program, supports Volume 1 of the EIS. Following the introduction, Chapter 2 contains background information related to the SRS and the framework of environmental regulations pertinent to spent nuclear fuel management. Chapter 3 identifies spent nuclear fuel management alternatives that DOE could implement at the SRS, and summarizes their potential environmental consequences. Chapter 4 describes the existing environmental resources of the SRS that spent nuclear fuel activities could affect. Chapter 5 analyzes in detail the environmental consequences of each spent nuclear fuel management alternative and describes cumulative impacts. The chapter also contains information on unavoidable adverse impacts, commitment of resources, short-term use of the environment and mitigation measures

  16. "The Invisible Staff": A Qualitative Analysis of Environmental Service Workers' Perceptions of the VA Clostridium difficile Prevention Bundle Using a Human Factors Engineering Approach.

    Science.gov (United States)

    Yanke, Eric; Moriarty, Helene; Carayon, Pascale; Safdar, Nasia

    2018-06-11

    Using a novel human factors engineering approach, the Systems Engineering Initiative for Patient Safety model, we evaluated environmental service workers' (ESWs) perceptions of barriers and facilitators influencing adherence to the nationally mandated Department of Veterans Affairs Clostridium difficile infection (CDI) prevention bundle. A focus group of ESWs was conducted. Qualitative analysis was performed employing a visual matrix display to identify barrier/facilitator themes related to Department of Veterans Affairs CDI bundle adherence using the Systems Engineering Initiative for Patient Safety work system as a framework. Environmental service workers reported adequate cleaning supplies/equipment and displayed excellent knowledge of CDI hand hygiene requirements. Environmental service workers described current supervisory practices as providing an acceptable amount of time to clean CDI rooms, although other healthcare workers often pressured ESWs to clean rooms more quickly. Environmental service workers reported significant concern for CDI patients' family members as well as suggesting uncertainty regarding the need for family members to follow infection prevention practices. Small and cluttered patient rooms made cleaning tasks more difficult, and ESW cleaning tasks were often interrupted by other healthcare workers. Environmental service workers did not feel comfortable asking physicians for more time to finish cleaning a room nor did ESWs feel comfortable pointing out lapses in physician hand hygiene. Multiple work system components serve as barriers to and facilitators of ESW adherence to the nationally mandated Department of Veterans Affairs CDI bundle. Environmental service workers may represent an underappreciated resource for hospital infection prevention, and further efforts should be made to engage ESWs as members of the health care team.

  17. Engineering geology and environmental protection

    Energy Technology Data Exchange (ETDEWEB)

    Sergeev, E M

    1979-01-01

    A classification is made of the anthropogenic processes in the environment into global, local, universally distributed, zonal, regional, and essentially local processes. Engineering geology is defined as the principal science concerned with the study of the geological medium which in turn involves the study of fossil fuel geology. 22 references.

  18. Extended Operation of Stirling Convertors at NASA Glenn Research Center

    Science.gov (United States)

    Oriti, Salvatore, M.

    2012-01-01

    NASA Glenn Research Center (GRC) has been supporting development of free-piston Stirling conversion technology for spaceflight electrical power generation since 1999. GRC has also been supporting the development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG project is providing life, reliability, and performance data for the Advanced Stirling Convertor (ASC). The Thermal Energy Conversion branch at GRC is conducting extended operation of several free-piston Stirling convertors. The goal of this effort is to generate long-term performance data (tens of thousands of hours) on multiple units to build a life and reliability database. Currently, GRC is operating 18 convertors. This hardware set includes Technology Demonstration Convertors (TDCs) from Infinia Corporation, of which one pair (TDCs #13 and #14) has accumulated over 60,000 hr (6.8 years) of operation. Also under test are various Sunpower, Inc. convertors that were fabricated during the ASC development activity, including ASC-0, ASC-E (including those in the ASRG engineering unit), and ASC-E2. The ASC-E2s also completed, or are in progress of completing workmanship vibration testing, performance mapping, and extended operation. Two ASC-E2 units will also be used for durability testing, during which components will be stressed to levels above nominal mission usage. Extended operation data analyses from these tests are covered in this paper.

  19. Real-time environmental monitoring at the Japan Nuclear Cycle Development Institute O-arai Engineering Center. Using the internet to promote safety and environmental transparency

    International Nuclear Information System (INIS)

    Motomatsu, Sheila; Nakashima Inoue, Naoko

    2000-12-01

    The report documents the results of an effort at the Japan Nuclear Cycle Development Institute O-arai Engineering Center (JNC/OEC) to provide via the Internet, in real-time, environmental monitoring data to promote safety and environmental transparency. Provided in Japanese as well as in English, the Internet site provides assurance that OEC nuclear operations are being conducted in a manner that is safe to both people in the surrounding area and the environment. This work conducted by Environmental Monitoring Team of the OEC Safety Administration Section fulfilled the assignment to release data real-time via the Internet tasked by the Information Disclosure Section of the JNC Headquarters Public Relations Division. The work conducted by the visiting exchange scientist fulfilled the experimental portion of Action Sheet 34 of the Agreement between JNC and DOE for Cooperation in Research and Development Concerning Nuclear Material Control and Accounting Measures for Safeguards and Nonproliferation. In Japan, the project for Action Sheet 34 Personnel Exchange on Remote Monitoring and Transparency' entailed both a study and an experiment on how remote monitoring technologies can be used to promote nonproliferation, environmental and safety transparency. Environmental airborne radionuclide monitoring falls under the definition of remote monitoring technology more broadly defined as 'remotely accessed unattended monitoring system technology'. (author)

  20. Hydropower and Environmental Resource Assessment (HERA): a computational tool for the assessment of the hydropower potential of watersheds considering engineering and socio-environmental aspects.

    Science.gov (United States)

    Martins, T. M.; Kelman, R.; Metello, M.; Ciarlini, A.; Granville, A. C.; Hespanhol, P.; Castro, T. L.; Gottin, V. M.; Pereira, M. V. F.

    2015-12-01

    The hydroelectric potential of a river is proportional to its head and water flows. Selecting the best development alternative for Greenfield projects watersheds is a difficult task, since it must balance demands for infrastructure, especially in the developing world where a large potential remains unexplored, with environmental conservation. Discussions usually diverge into antagonistic views, as in recent projects in the Amazon forest, for example. This motivates the construction of a computational tool that will support a more qualified debate regarding development/conservation options. HERA provides the optimal head division partition of a river considering technical, economic and environmental aspects. HERA has three main components: (i) pre-processing GIS of topographic and hydrologic data; (ii) automatic engineering and equipment design and budget estimation for candidate projects; (iii) translation of division-partition problem into a mathematical programming model. By integrating an automatic calculation with geoprocessing tools, cloud computation and optimization techniques, HERA makes it possible countless head partition division alternatives to be intrinsically compared - a great advantage with respect to traditional field surveys followed by engineering design methods. Based on optimization techniques, HERA determines which hydro plants should be built, including location, design, technical data (e.g. water head, reservoir area and volume, engineering design (dam, spillways, etc.) and costs). The results can be visualized in the HERA interface, exported to GIS software, Google Earth or CAD systems. HERA has a global scope of application since the main input data area a Digital Terrain Model and water inflows at gauging stations. The objective is to contribute to an increased rationality of decisions by presenting to the stakeholders a clear and quantitative view of the alternatives, their opportunities and threats.

  1. A summary of the environmental restoration program retrieval demonstration project at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    McQuary, J.

    1991-02-01

    This report provides a summary of the Environmental Restoration Program's Retrieval Demonstration Project at the Idaho National Engineering Laboratory. This project developed concepts for demonstrating facilities and equipment for the retrieval of buried transuranic mixed waste at the INEL. Included is a brief assessment of the viability, cost effectiveness, and safety of retrieval based on the developed concept. Changes made in Revision 1 reflect editorial changes only. 31 refs., 1 fig

  2. Estudo potenciométrico de reações oscilantes para a determinação de ácido ascórbico, por perturbação do padrão de oscilação

    OpenAIRE

    Baliza, Patrícia Xavier

    2006-01-01

    Neste trabalho, é proposta a determinação de ácido ascórbico em amostras de medicamentos, utilizando-se um sistema potenciométrico, desenvolvido no laboratório que permitiu o estudo de reações oscilantes. Esse método baseia-se na determinação de ácido ascórbico utilizando como princípio o efeito desta substância no padrão de oscilação da reação de Belousov-Zhabotinskii. As condições experimentais como temperatura e concentrações dos reagentes, foram otimizadas. O sistema era constituído de...

  3. Fluid mechanics of environmental interfaces

    CERN Document Server

    Gualtieri, Carlo

    2008-01-01

    Fluid Mechanics of Environmental Interfaces describes the concept of the environmental interface, defined as a surface between two either abiotic or biotic systems. These are in relative motion and exchange mass, heat and momentum through biophysical and/or chemical processes. These processes are fluctuating temporally and spatially.The book will be of interest to graduate students, PhD students as well as researchers in environmental sciences, civil engineering and environmental engineering, (geo)physics and applied mathematics.

  4. Comparison of the clinical performance of an HPV mRNA test and an HPV DNA test in triage of atypical squamous cells of undetermined significance (ASC-US)

    DEFF Research Database (Denmark)

    Waldstrom, M; Ornskov, D

    2012-01-01

    The effect of triaging women with atypical squamous cells of undetermined significance (ASC-US) with human papillomavirus (HPV) DNA testing has been well documented. New tests detecting HPV E6/E7 mRNA are emerging, claiming to be more specific for detecting high-grade disease. We evaluated the cl...

  5. Environmental development plan for transportation programs: FY80 update

    Energy Technology Data Exchange (ETDEWEB)

    Saricks, C.L.; Singh, M.K.; Bernard, M.J. III; Bevilacqua, O.M.

    1980-09-01

    This is the second annual update of the environmental development plan (EDP) for transportation programs. It has been prepared as a cooperative effort of the Assistant Secretaries for Conservation and Solar Energy (ASCS) Office of Transportation Programs (CS/TP) and the Environment (ASEV) Office of Environmental Assessments. EDPs identify the ecosystem, resource, physical environment, health, safety, socioeconomic, and environmental control concerns associated with DOE programs. The programs include the research, development, demonstration, and assessment (RDD and A) of 14 transportation technologies and several strategy implementation projects. This EDP update presents a research and assessment plan for resolving any potentially adverse environmental concerns arising from these programs. The EDP process provides a framework for: incorporating environmental concerns into CS/TP planning and decision processes early to ensure they are assigned the same importance as technological, fiscal, and institutional concerns in decision making; resolving environmental concerns concurrently with energy technology and strategy development; and providing a research schedule that mitigates adverse environmental effects through sound technological design or policy analysis. This EDP also describes the status of each environmental concern and the plan for its resolution. Much of ongoing DOE reseirch and technology development is aimed at resolving concerns identified in this EDP. Each EDP is intended to be so comprehensive that no concerns escape notice. Care is taken to include any CS/TP action that may eventually require an Environmental Impact Statement. Because technology demonstration and commercialization tend to raise more environmental concerns than other portions of the transportation program, most of this EDP addresses these concerns.

  6. Safety Research Experiment Facilities, Idaho National Engineering Laboratory, Idaho. Draft environmental statement

    International Nuclear Information System (INIS)

    1977-01-01

    This environmental statement was prepared in accordance with the National Environmental Policy Act of 1969 (NEPA) in support of the Energy Research and Development Administration's (ERDA) proposal for legislative authorization and appropriations for the Safety Research Experiment Facilities (SAREF) Project. The purpose of the proposed project is to modify some existing facilities and provide a new test facility at the Idaho National Engineering Laboratory (INEL) for conducting fast breeder reactor (FBR) safety experiments. The SAREF Project proposal has been developed after an extensive study which identified the FBR safety research needs requiring in-reactor experiments and which evaluated the capability of various existing and new facilities to meet these needs. The proposed facilities provide for the in-reactor testing of large bundles of prototypical FBR fuel elements under a wide variety of conditions, ranging from those abnormal operating conditions which might be expected to occur during the life of an FBR power plant to the extremely low probability, hypothetical accidents used in the evalution of some design options and in the assessment of the long-term potential risk associated with wide-scale deployment of the FBR

  7. Endothelial differentiation of human stem cells seeded onto electrospun polyhydroxybutyrate/polyhydroxybutyrate-co-hydroxyvalerate fiber mesh.

    Directory of Open Access Journals (Sweden)

    Alessandra Zonari

    Full Text Available Tissue engineering is based on the association of cultured cells with structural matrices and the incorporation of signaling molecules for inducing tissue regeneration. Despite its enormous potential, tissue engineering faces a major challenge concerning the maintenance of cell viability after the implantation of the constructs. The lack of a functional vasculature within the implant compromises the delivery of nutrients to and removal of metabolites from the cells, which can lead to implant failure. In this sense, our investigation aims to develop a new strategy for enhancing vascularization in tissue engineering constructs. This study's aim was to establish a culture of human adipose tissue-derived stem cells (hASCs to evaluate the biocompatibility of electrospun fiber mesh made of polyhydroxybutyrate (PHB and its copolymer poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHB-HV and to promote the differentiation of hASCs into the endothelial lineage. Fiber mesh was produced by blending 30% PHB with 70% PHB-HV and its physical characterization was conducted using scanning electron microscopy analysis (SEM. Using electrospinning, fiber mesh was obtained with diameters ranging 300 nm to 1.3 µm. To assess the biological performance, hASCs were extracted, cultured, characterized by flow cytometry, expanded and seeded onto electrospun PHB/PHB-HV fiber mesh. Various aspects of the cells were analyzed in vitro using SEM, MTT assay and Calcein-AM staining. The in vitro evaluation demonstrated good adhesion and a normal morphology of the hASCs. After 7, 14 and 21 days of seeding hASCs onto electrospun PHB/PHB-HV fiber mesh, the cells remained viable and proliferative. Moreover, when cultured with endothelial differentiation medium (i.e., medium containing VEGF and bFGF, the hASCs expressed endothelial markers such as VE-Cadherin and the vWF factor. Therefore, the electrospun PHB/PHB-HV fiber mesh appears to be a suitable material that can be used in

  8. Endothelial differentiation of human stem cells seeded onto electrospun polyhydroxybutyrate/polyhydroxybutyrate-co-hydroxyvalerate fiber mesh.

    Science.gov (United States)

    Zonari, Alessandra; Novikoff, Silviene; Electo, Naira R P; Breyner, Natália M; Gomes, Dawidson A; Martins, Albino; Neves, Nuno M; Reis, Rui L; Goes, Alfredo M

    2012-01-01

    Tissue engineering is based on the association of cultured cells with structural matrices and the incorporation of signaling molecules for inducing tissue regeneration. Despite its enormous potential, tissue engineering faces a major challenge concerning the maintenance of cell viability after the implantation of the constructs. The lack of a functional vasculature within the implant compromises the delivery of nutrients to and removal of metabolites from the cells, which can lead to implant failure. In this sense, our investigation aims to develop a new strategy for enhancing vascularization in tissue engineering constructs. This study's aim was to establish a culture of human adipose tissue-derived stem cells (hASCs) to evaluate the biocompatibility of electrospun fiber mesh made of polyhydroxybutyrate (PHB) and its copolymer poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHB-HV) and to promote the differentiation of hASCs into the endothelial lineage. Fiber mesh was produced by blending 30% PHB with 70% PHB-HV and its physical characterization was conducted using scanning electron microscopy analysis (SEM). Using electrospinning, fiber mesh was obtained with diameters ranging 300 nm to 1.3 µm. To assess the biological performance, hASCs were extracted, cultured, characterized by flow cytometry, expanded and seeded onto electrospun PHB/PHB-HV fiber mesh. Various aspects of the cells were analyzed in vitro using SEM, MTT assay and Calcein-AM staining. The in vitro evaluation demonstrated good adhesion and a normal morphology of the hASCs. After 7, 14 and 21 days of seeding hASCs onto electrospun PHB/PHB-HV fiber mesh, the cells remained viable and proliferative. Moreover, when cultured with endothelial differentiation medium (i.e., medium containing VEGF and bFGF), the hASCs expressed endothelial markers such as VE-Cadherin and the vWF factor. Therefore, the electrospun PHB/PHB-HV fiber mesh appears to be a suitable material that can be used in combination with

  9. Career Fairs | College of Engineering & Applied Science

    Science.gov (United States)

    Engineering Concentration on Ergonomics M.S. Program in Computer Science Interdisciplinary Concentration on Energy Doctoral Programs in Engineering Non-Degree Candidate Departments Biomedical Engineering Biomedical Engineering Industry Advisory Council Civil & Environmental Engineering Civil &

  10. Staged fluidized-bed coal combustor for boiler retrofit

    International Nuclear Information System (INIS)

    Rehmat, A.; Dorfman, L.; Shibayama, G.; Waibel, R.

    1991-01-01

    The Advanced Staged Fluidized-Bed Coal Combustion System (ASC) is a novel clean coal technology for either coal-fired repowering of existing boilers or for incremental power generation using combined-cycle gas turbines. This new technology combines staged combustion for gaseous emission control, in-situ sulfur capture, and an ash agglomeration/vitrification process for the agglomeration/vitrification of ash and spent sorbent, thus rendering solid waste environmentally benign. The market for ASC is expected to be for clean coal-fired repowering of generating units up to 250 MW, especially for units where space is limited. The expected tightening of the environmental requirements on leachable solids residue by-products could considerably increase the marketability for ASC. ASC consists of modular low-pressure vessels in which coal is partially combusted and gasified using stacked fluidized-bed processes to produce low-to-medium-Btu, high-temperature gas. This relatively clean fuel gas is used to repower/refuel existing pulverized-coal, natural gas, or oil-fired boilers using bottom firing and reburning techniques. The benefits of ASC coal-fired repowering include the ability to repower boilers without obtaining additional space while meeting the more stringent environmental requirements of the future. Low NO x , SO x , and particulate levels are expected while a nonleachable solid residue with trace metal encapsulation is produced. ASC also minimizes boiler modification and life-extension expenditures. Repowered efficiencies can be restored to the initial operating plant efficiency, and the existing boiler capacity can be increased by 10%. Preliminary cost estimates indicate that ASC will have up to a $250/kW capital cost advantage over existing coal-fired repowering options. 4 figs., 4 tabs

  11. LCA as an environmental technology development performance indicator of engineered nano-materials and their application in polymers

    DEFF Research Database (Denmark)

    Miseljic, Mirko; Olsen, Stig Irving; Hauschild, Michael Zwicky

    project is aimed to be holistic and thereby include the entire life cycle of the nano‐polymer products and not be like the current frequently applied nano‐material LCA case study approaches where the life cycle is reduced and system boundaries substantially limited. In order to perform accurate......Engineered nano‐material (ENM) application in products has in recent years developed to an important market segment but with rising environmental concerns, as the environmental life cycle impacts, especially toxicity of nanoparticles, are not assessed. Life cycle assessment (LCA) is a holistic tool...... to the conventional ways of attaining these in the polymer product industry. To assure environmental sustainability LCA will be performed within the MINANO project and more precisely comparing the new ENM technology and the conventional technology approach to attain the same functionalities. The LCA in the MINANO...

  12. Pacific Northwest Laboratory annual report for 1982 to the DOE Office of the Assistant Secretary for Environmental Protection, Safety and Emergency Preparedness. Part 5. Environmental and occupational protection, assessment, and engineering

    International Nuclear Information System (INIS)

    Bair, W.J.

    1983-02-01

    Part 5 of the 1982 Annual Report to the Department of Energy's Office of Environmental Protection, Safety and Emergency Preparedness presents Pacific Northwest Laboratory's progress on work performed for the Office of Environmental Programs, Office of Operational Safety, and the Office of Nuclear Safety. The report is in three sections, introduced by blue divider pages, corresponding to the program elements: Technology Impacts, Environmental and Safety Engineering, Operational and Environmental Safety. In each section, articles describe progress made during FY 1982 on individual projects, as identified by the Field Task Proposal/Agreement. Authors of these articles represent a broad spectrum of capabilities derived from various segments of the Laboratory, reflecting the interdisciplinary nature of the work

  13. Sliding and Rocking of Unanchored Components and Structures: Chapter 7.6 ASCE 4 Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    S. R. Jensen

    2011-04-01

    Chapter 7.6 of ASCE 4-Rev 2, Seismic Analysis of Safety-Related Nuclear Structures: Standard and Commentary, provides updated guidance for analysis of rocking and sliding of unanchored structures and components subjected to seismic load. This guidance includes provisions both for simplified approximate energy-based approaches, and for detailed probabilistic time history analysis using nonlinear methods. Factors to be applied to the analytical results are also provided with the intent of ensuring achievement of the 80% non-exceedence probability target of the standard. The present paper surveys the published literature supporting these provisions. The results of available testing and analysis are compared to results produced by both simplified and probabilistic approaches. In addition, adequacy of the standard's provisions for analysis methods and factors is assessed. A comparison is made between the achieved level of conservatism and the standard's non-exceedence probability target.

  14. Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: perspectives from stem cell biology and molecular medicine.

    Science.gov (United States)

    Wu, Ling; Cai, Xiaoxiao; Zhang, Shu; Karperien, Marcel; Lin, Yunfeng

    2013-05-01

    Adipose-derived stem cells (ASCs) have been discovered for more than a decade. Due to the large numbers of cells that can be harvested with relatively little donor morbidity, they are considered to be an attractive alternative to bone marrow derived mesenchymal stem cells. Consequently, isolation and differentiation of ASCs draw great attention in the research of tissue engineering and regenerative medicine. Cartilage defects cause big therapeutic problems because of their low self-repair capacity. Application of ASCs in cartilage regeneration gives hope to treat cartilage defects with autologous stem cells. In recent years, a lot of studies have been performed to test the possibility of using ASCs to re-construct damaged cartilage tissue. In this article, we have reviewed the most up-to-date articles utilizing ASCs for cartilage regeneration in basic and translational research. Our topic covers differentiation of adipose tissue derived mesenchymal stem cells into chondrocytes, increased cartilage formation by co-culture of ASCs with chondrocytes and enhancing chondrogenic differentiation of ASCs by gene manipulation. Copyright © 2012 Wiley Periodicals, Inc.

  15. Incorporating a Systems Approach into Civil and Environmental Engineering Curricula: Effect on Course Redesign, and Student and Faculty Attitudes

    Science.gov (United States)

    Hayden, Nancy J.; Rizzo, Donna M.; Dewoolkar, Mandar M.; Neumann, Maureen D.; Lathem, Sandra; Sadek, Adel

    2011-01-01

    This paper presents a brief overview of the changes made during our department level reform (DLR) process (Grant Title: "A Systems Approach for Civil and Environmental Engineering Education: Integrating Systems Thinking, Inquiry-Based Learning and Catamount Community Service-Learning Projects") and some of the effects of these changes on…

  16. Pedagogies to Achieve Sustainability Learning Outcomes in Civil and Environmental Engineering Students

    Directory of Open Access Journals (Sweden)

    Angela R. Bielefeldt

    2013-10-01

    Full Text Available The civil and environmental engineering disciplines have identified the levels of knowledge about sustainability that are desirable for students to achieve as they graduate with a bachelor’s degree, as well as sustainability-related competencies to be obtained during a master’s degree, and on-the-job, prior to professional licensure. Different pedagogies are better suited to help students attain these levels of cognitive ability, while also developing affective outcomes. This paper provides examples of different methods that have been used at one institution to educate engineering students about sustainability, supported with data that indicates whether the method successfully achieved the targeted learning outcomes. Lectures, in-class active learning, readings, and appropriately targeted homework assignments can achieve basic sustainability knowledge and comprehension by requiring students to define, identify, and explain aspects of sustainability. Case studies and the application of software tools are good methods to achieve application and analysis competencies. Project-based learning (PBL and project-based service-learning (PBSL design projects can reach the synthesis level and may also develop affective outcomes related to sustainability. The results provide examples that may apply to a wider range of disciplines and suggest sustainability outcomes that are particularly difficult to teach and/or assess.

  17. 40 CFR 1054.140 - What is my engine's maximum engine power and displacement?

    Science.gov (United States)

    2010-07-01

    ... internal diameter of 6.00 cm and a 6.25 cm stroke length, the rounded displacement would be: (1) × (6.00/2... power and displacement? 1054.140 Section 1054.140 Protection of Environment ENVIRONMENTAL PROTECTION... engine power and displacement? This section describes how to quantify your engine's maximum engine power...

  18. Shrubs as ecosystem engineers across an environmental gradient: effects on species richness and exotic plant invasion.

    Science.gov (United States)

    Kleinhesselink, Andrew R; Magnoli, Susan M; Cushman, J Hall

    2014-08-01

    Ecosystem-engineering plants modify the physical environment and can increase species diversity and exotic species invasion. At the individual level, the effects of ecosystem engineers on other plants often become more positive in stressful environments. In this study, we investigated whether the community-level effects of ecosystem engineers also become stronger in more stressful environments. Using comparative and experimental approaches, we assessed the ability of a native shrub (Ericameria ericoides) to act as an ecosystem engineer across a stress gradient in a coastal dune in northern California, USA. We found increased coarse organic matter and lower wind speeds within shrub patches. Growth of a dominant invasive grass (Bromus diandrus) was facilitated both by aboveground shrub biomass and by growing in soil taken from shrub patches. Experimental removal of shrubs negatively affected species most associated with shrubs and positively affected species most often found outside of shrubs. Counter to the stress-gradient hypothesis, the effects of shrubs on the physical environment and individual plant growth did not increase across the established stress gradient at this site. At the community level, shrub patches increased beta diversity, and contained greater rarified richness and exotic plant cover than shrub-free patches. Shrub effects on rarified richness increased with environmental stress, but effects on exotic cover and beta diversity did not. Our study provides evidence for the community-level effects of shrubs as ecosystem engineers in this system, but shows that these effects do not necessarily become stronger in more stressful environments.

  19. Service Modeling for Service Engineering

    Science.gov (United States)

    Shimomura, Yoshiki; Tomiyama, Tetsuo

    Intensification of service and knowledge contents within product life cycles is considered crucial for dematerialization, in particular, to design optimal product-service systems from the viewpoint of environmentally conscious design and manufacturing in advanced post industrial societies. In addition to the environmental limitations, we are facing social limitations which include limitations of markets to accept increasing numbers of mass-produced artifacts and such environmental and social limitations are restraining economic growth. To attack and remove these problems, we need to reconsider the current mass production paradigm and to make products have more added values largely from knowledge and service contents to compensate volume reduction under the concept of dematerialization. Namely, dematerialization of products needs to enrich service contents. However, service was mainly discussed within marketing and has been mostly neglected within traditional engineering. Therefore, we need new engineering methods to look at services, rather than just functions, called "Service Engineering." To establish service engineering, this paper proposes a modeling technique of service.

  20. The Japanese aerial attack on Hanford Engineer Works

    Science.gov (United States)

    Clark, Charles W.

    The day before the Pearl Harbor attack, December 6, 1941, the University of Chicago Metallurgical Laboratory was given four goals: design a plutonium (Pu) bomb; produce Pu by irradiation of uranium (U); extract Pu from the irradiated U; complete this in time to be militarily significant. A year later the first controlled nuclear chain reaction was attained in Chicago Pile 1 (CP-1). In January 1943, Hanford, WA was chosen as the site of the Pu factory. Neutron irradiation of 238U was to be used to make 239Pu. This was done by a larger version of CP-1, Hanford Reactor B, which went critical in September 1944. By July 1945 it had made enough Pu for two bombs: one used at the Trinity test in July; the other at Nagasaki, Japan in August. I focus on an ironic sidelight to this story: disruption of hydroelectric power to Reactor B by a Japanese fire balloon attack on March 10, 1945. This activated the costly coal-fired emergency backup plant to keep the reactor coolant water flowing, thwarting disaster and vindicating the conservative design of Hanford Engineer Works. Management of the Hanford Engineer Works in World War II, H. Thayer (ASCE Press 1996).

  1. Integrating Social Science, Environmental Science, and Engineering to Understand Vulnerability and Resilience to Environmental Hazards in the Bengal Delta

    Science.gov (United States)

    Gilligan, J. M.; Ackerly, B.; Goodbred, S. L.

    2013-12-01

    In populated delta environments, it is impossible to separate human and natural systems. Human activities change the landscape by altering the dynamics of water and sediment and in return, humans themselves are affected by the natural and anthropogenic changes to the landscape. Such interactions can also have significant impacts on the ecology and natural resources of a delta system, affecting local and regional food supply, livelihoods, and economies, particularly in developing nations. Successful adaptation to environmental change in a strongly coupled human-natural system, such as the Bengal delta, requires understanding how the physical environment and the changing social, political, and economic conditions of people's lives interact. Research on human-delta interactions has largely focused on macro-scale effects from major dams, water diversions, and catchment-scale land use; but at the smaller scale of households and communities, decisions, actions, and outcomes may occur abruptly and have significant local impacts (positive or negative). Southwest Bangladesh experiences profound environmental problems at the local human-landscape interface, including groundwater salinity, soil fertility, conflicting land-use practices, management of engineering structures, and declining land-surface elevations. The impacts of climate-induced sea-level rise, especially with respect to population migration, receive great attention and concern, but neither sea level rise nor migration occurs against a background of static physical or human environments. For example, changing land use (e.g., building embankments, which affect drainage, sediment transport, and the evolution of tidal channels; and the transformation of rice fields to shrimp aquaculture, which affects soil chemistry, labor markets, river ecology, and possibly the integrity of embankments) can significantly change the impact that sea level rise will have on flood hazards and the resulting effect on people living on

  2. Adipose-Derived-Stem-Cell-Seeded Fibrin Matrices for Periodontal Ligament Engineering: The Need for Dynamic Strain

    NARCIS (Netherlands)

    de Jong, Thijs; Oostendorp, Corien; Bakker, Astrid D.; van Kuppevelt, Toin H.; Smit, Theo H.

    2017-01-01

    Introduction: The periodontal ligament (PDL) connects the tooth to the alveolar bone. For PDL regeneration after tissue damage, we propose human adipose-derived stem cells (hASCs) embedded in fibrin. We showed previously that hASCs in fibrin extensively produce collagen, but in a non-functional,

  3. Environmental contaminants: assessment and control

    National Research Council Canada - National Science Library

    Vallero, Daniel A

    2004-01-01

    ... Understanding Policy by Understanding Science Connections and Interrelationships of Environmental Science Environmental Assessment and Intervention Engineering Technical Note: Cleaning up a Hazardous Waste Site Social Aspects of Environmental Science Introduction to Environmental Policy The National Environmental Policy Act Issues in Environmental Science: Co...

  4. Environmental surveillance for the EG and G Idaho Radioactive Waste Management areas at the Idaho National Engineering Laboratory. Annual report 1985

    International Nuclear Information System (INIS)

    Reyes, B.D.; Case, M.J.; Wilhelmsen, R.N.

    1986-08-01

    The 1985 environmental surveillance report for the EG and G Idaho, Inc., radioactive waste management areas at the Idaho National Engineering Laboratory describes the environmental monitoring activities at the Radioactive Waste Management Complex (RWMC), the Waste Experimental Reduction Facility (WERF), the Process Experimental Pilot Plant (PREPP), and two surplus facilities. The purpose of these monitoring activities is to provide for continuous evaluation and awareness of environmental conditions resulting from current operations, to detect significant trends, and to project possible future conditions. This report provides a public record comparing RWMC, WERF, PREPP, and surplus facility environmental data with past results and radiation protection standards or concentration guides established for operation of Department of Energy facilities

  5. Modern water resources engineering

    CERN Document Server

    Yang, Chih

    2014-01-01

    The Handbook of Environmental Engineering series is an incredible collection of methodologies that study the effects of pollution and waste in their three basic forms: gas, solid, and liquid. This exciting new addition to the series, Volume 15: Modern Water Resources Engineering , has been designed to serve as a water resources engineering reference book as well as a supplemental textbook. We hope and expect it will prove of equal high value to advanced undergraduate and graduate students, to designers of water resources systems, and to scientists and researchers. A critical volume in the Handbook of Environmental Engineering series, chapters employ methods of practical design and calculation illustrated by numerical examples, include pertinent cost data whenever possible, and explore in great detail the fundamental principles of the field. Volume 15: Modern Water Resources Engineering, provides information on some of the most innovative and ground-breaking advances in the field today from a panel of esteemed...

  6. Effects of hypoxia on the immunomodulatory properties of adipose tissue-derived mesenchymal stem cells

    NARCIS (Netherlands)

    M. Roemeling-Van Rhijn (Marieke); F.K.F. Mensah (Fane ); S.S. Korevaar (Sander); M.J.C. Leijs (Maarten J.C.); G.J.V.M. van Osch (Gerjo); J.N.M. IJzermans (Jan); M.G.H. Betjes (Michiel); C.C. Baan (Carla); W. Weimar (Willem); M.J. Hoogduijn (Martin)

    2013-01-01

    textabstractAdipose tissue-derived mesenchymal stem cells (ASC) are of great interest as a cellular therapeutic agent for regenerative and immunomodulatory purposes. The function of ASC adapts to environmental conditions, such as oxygen tension. Oxygen levels within tissues are typically much lower

  7. 40 CFR 1048.330 - May I sell engines from an engine family with a suspended certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false May I sell engines from an engine... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.330 May I sell engines from an engine...

  8. Implementing of action plans for risk communication on the uranium mining sites remedy at Ningyo-toge Environmental Engineering Center (1) (Contract research)

    International Nuclear Information System (INIS)

    Yabuta, Naohiro; Kawai, Jun; Hikawa, Tamae; Tokizawa, Takayuki; Sato, Kazuhiko; Koga, Osamu

    2008-11-01

    On the closure of uranium mine site at Ningyo-Toge Environmental Engineering Center Japan Atomic Energy Agency, the action plans for risk communication with residence and local governments were developed and implemented. Under a practical program of the risk communication, an ethnographical research on Ningyo-Toge Environmental Engineering Center has been conducted by local high school students. The research was focused on several social groups such as engineers at the Center and residents around Ningyo-toge and described their circumstances from the past to the present, since the discovery of the uranium outcrop 1955. In addition, it should be noted that as a results, the research project led several effects listed below; 1) High school students understood significance of the uranium development projects implemented at Ningyo-toge, 2) Differences of standpoints between local residents and Ningyo-toge became clearer, 3) Foundation to communicate between local communities and Ningyo-toge was found out, and 4) The educational program on an ethnographical research was conducted autonomously by local high school students. (author)

  9. Avaliação da interferência do ácido ascórbico na detecção da glicosúria Evaluation of ascorbic acid interference in the detection of glycosuria

    Directory of Open Access Journals (Sweden)

    Jaime Murilo Fernandes Costa

    2012-02-01

    Full Text Available INTRODUÇÃO: O ácido ascórbico (vitamina C é comumente ingerido como suplemento vitamínico. É uma vitamina hidrossolúvel, excretada pela urina e pode interferir nos ensaios laboratoriais, como nas reações de oxirredução para detecção da glicosúria. OBJETIVO: Este trabalho tem como objetivo avaliar a interferência do ácido ascórbico na detecção de glicosúria pelo método de química seca por meio do uso de tiras reagentes. MATERIAIS E MÉTODOS: Amostras de urina foram avaliadas no analisador da marca Clinitek Atlas (Siemens Healthcare Diagnostics Inc., EUA. Foram selecionadas quatro amostras de urina com diferentes concentrações de glicose: 100 mg/dl, 250 mg/dl, 500 mg/dl e 1.000 mg/dl. Para cada concentração de glicose foram criadas cinco alíquotas, adicionando-se uma solução de ácido ascórbico 200 mg/dl, suficiente para obter uma concentração final de ácido ascórbico de 20 mg/dl no primeiro tubo, de 50 mg/dl no segundo tubo, de 270 mg/dl no terceiro tubo, de 1.000 mg/dl no quarto tubo e de 2.000 mg/dl no quinto tubo. Após essa adição, as amostras foram novamente avaliadas no analisador Clinitek Atlas. RESULTADOS: Nas amostras com concentração de 20 mg/dl de ácido, não se evidenciou interferência. Nas concentrações iguais e acima de 50 mg/dl, a interferência do ácido ascórbico se fez presente, sendo que o fato foi caracterizado pelos resultados falso negativos para detecção da glicose urinária. CONCLUSÃO: Os resultados demonstraram a interferência do ácido ascórbico no método da química seca (tiras reagentes, subestimando o nível de glicose urinária.INTRODUCTION: Ascorbic acid (vitamin C is commonly used as a vitamin supplement. It is a water soluble vitamin, which is excreted through urine and may interfere in laboratory tests as well as redox reactions for urinary glucose detection. OBJECTIVE: This study aims to assess ascorbic acid interference in glycosuria detection by dry chemistry

  10. Environmental Field Surveys, EMF Rapid Program, Engineering Project No.3

    Energy Technology Data Exchange (ETDEWEB)

    Enertech Consultants

    1996-04-01

    The EMF Research and Public Information Dissemination Program (RAPID) includes several engineering research in the area of exposure assessment and source characterization. RAPID engineering project No. 3: ''Environmental Field Surveys'' was performed to obtain information on the levels and characteristics of different environments, for which only limited data were available, especially in comparison to magnetic field data for the residential environment and for electric utility facilities, such as power lines and substations. This project was also to provide information on the contribution of various field sources in the surveyed environments. Magnetic field surveys were performed at four sites for each of five environments: schools, hospitals, office buildings, machine shops, and grocery stores. Of the twenty sites surveyed, 11 were located in the San Francisco Bay Area and 9 in Massachusetts. The surveys used a protocol based on magnetic field measurements and observation of activity patterns, designed to provide estimates of magnetic field exposure by type of people and by type of sources. The magnetic field surveys conducted by this project produced a large amount of data which will form a part of the EMF measurement database Field and exposure data were obtained separately for ''area exposure'' and ''at exposure points''. An exposure point is a location where persons engage in fixed, site specific activities near a local source that creates a significant increase in the area field. The area field is produced by ''area sources'', whose location and field distribution is in general not related to the location of the people in the area.

  11. Aerospace Ceramic Materials: Thermal, Environmental Barrier Coatings and SiC/SiC Ceramic Matrix Composites for Turbine Engine Applications

    Science.gov (United States)

    Zhu, Dongming

    2018-01-01

    Ceramic materials play increasingly important roles in aerospace applications because ceramics have unique properties, including high temperature capability, high stiffness and strengths, excellent oxidation and corrosion resistance. Ceramic materials also generally have lower densities as compared to metallic materials, making them excellent candidates for light-weight hot-section components of aircraft turbine engines, rocket exhaust nozzles, and thermal protection systems for space vehicles when they are being used for high-temperature and ultra-high temperature ceramics applications. Ceramic matrix composites (CMCs), including non-oxide and oxide CMCs, are also recently being incorporated in gas turbine engines for high pressure and high temperature section components and exhaust nozzles. However, the complexity and variability of aerospace ceramic processing methods, compositions and microstructures, the relatively low fracture toughness of the ceramic materials, still remain the challenging factors for ceramic component design, validation, life prediction, and thus broader applications. This ceramic material section paper presents an overview of aerospace ceramic materials and their characteristics. A particular emphasis has been placed on high technology level (TRL) enabling ceramic systems, that is, turbine engine thermal and environmental barrier coating systems and non-oxide type SiC/SiC CMCs. The current status and future trend of thermal and environmental barrier coatings and SiC/SiC CMC development and applications are described.

  12. Safety and environmental protection - realization efforts regarding the authorization of power engineering plants

    International Nuclear Information System (INIS)

    Dreyhaupt, F.J.

    1982-01-01

    As to power plants the author calls special attention to three statements concerning questions on safety and environmental protection which play a decisive part in authorizing conventional and nuclear facilities. After investigating the most important legal fundamental principles for the authorization of power engineering plants, the Atomic Act and the Federal Immission Protection Act, the author discusses the problems that arise with the application of the authorization procedures. The reasons which can be made responsible for the long running periods of the authorization procedures and therewith of the realization of the site installation work are given. Finally, the author describes and judges the outlines of regulations for large scale furnaces and for the TA-air supplementary clause. (orig.) [de

  13. A review on carbon nanotubes in an environmental protection and green engineering perspective

    Directory of Open Access Journals (Sweden)

    Yit Thai Ong

    2010-06-01

    Full Text Available Recent developments in nanotechnologies have helped to benchmark carbon nanotubes (CNTs as one of the most studied nanomaterials. By taking advantages of CNTs extraordinary physical, chemical and electronic properties, a wide variety of applications has been proposed in various engineering fields. In this short review, the contribution of CNTs is addressed in terms of sustainable environment and green technologies perspective, such as waste water treatment, air pollution monitoring, biotechnologies, renewable energy technologies, supercapacitors and green nanocomposites. Consideration of CNTs for large scale application from the aspect of cost and potential hazards are also discussed. Based on the literature studied, CNTs pose a great potential as a promising material for application in various environmental fields.

  14. Environmental Survey preliminary report, Idaho National Engineering Laboratory, Idaho Falls, Idaho and Component Development and Integration Facility, Butte, Montana

    International Nuclear Information System (INIS)

    1988-09-01

    This report presents the preliminary findings of the first phase of the Environmental Survey of the United States Department of Energy's (DOE) Idaho National Engineering Laboratory (INEL) and Component Development and Integration Facility (CDIF), conducted September 14 through October 2, 1987. The Survey is being conducted by an interdisciplinary team of environmental specialists, led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. The team includes outside experts supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with the INEL and CDIF. The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. The on-site phase of the Survey involves the review of existing site environmental data, observations of the operations' carried on at the INEL and the CDIF, and interviews with site personnel. The Survey team developed a Sampling and Analysis (S ampersand A) Plan to assist in further assessing certain of the environmental problems identified during its on-site activities. The S ampersand A Plan will be executed by the Oak Ridge National Laboratory. When completed, the S ampersand A results will be incorporated into the INEL/CDIF Survey findings for inclusion into the Environmental Survey Summary Report. 90 refs., 95 figs., 77 tabs

  15. Environmental Survey preliminary report, Idaho National Engineering Laboratory, Idaho Falls, Idaho and Component Development and Integration Facility, Butte, Montana

    Energy Technology Data Exchange (ETDEWEB)

    1988-09-01

    This report presents the preliminary findings of the first phase of the Environmental Survey of the United States Department of Energy's (DOE) Idaho National Engineering Laboratory (INEL) and Component Development and Integration Facility (CDIF), conducted September 14 through October 2, 1987. The Survey is being conducted by an interdisciplinary team of environmental specialists, led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. The team includes outside experts supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with the INEL and CDIF. The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. The on-site phase of the Survey involves the review of existing site environmental data, observations of the operations' carried on at the INEL and the CDIF, and interviews with site personnel. The Survey team developed a Sampling and Analysis (S A) Plan to assist in further assessing certain of the environmental problems identified during its on-site activities. The S A Plan will be executed by the Oak Ridge National Laboratory. When completed, the S A results will be incorporated into the INEL/CDIF Survey findings for inclusion into the Environmental Survey Summary Report. 90 refs., 95 figs., 77 tabs.

  16. Concordancia entre los hallazgos citológicos de ASC-US en atrofia y metaplasia con la biopsia en el laboratorio de Patología de Clínica Colsanitas S.A. durante los años 2009 a 2012

    OpenAIRE

    Posada Restrepo, Alejandro

    2015-01-01

    Introducción: La categoría atipia de células escamosas de significado indeterminado (ASC-US) en la terminología Bethesda plantea un reto para el citólogo(a)/patólogo(a), necesitándose una estrecha correlación con otras herramientas diagnósticas para lograr un diagnóstico preciso y un tratamiento adecuado. Se puede observar ASC-US en extendidos con atrofia y metaplasia que dificultan la interpretación, haciéndose necesario otros métodos como la biopsia cervical para acercarnos al diagnóstico p...

  17. Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs: An experimental and in silico study

    Directory of Open Access Journals (Sweden)

    Abdorrahim Absalan

    2017-03-01

    Full Text Available Objective(s: To investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. In addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (TIPs using in silico studies. Materials and Methods: Human adipose derived stem cells (hASCs were studied under treatments with 2.5 µM/ml cinnamaldehyde, 0.1 µg/ml eugenol, 0.01% DMSO or any additive. The expression of TERT, AKT1 and DKC1 genes and the telomere length were assessed over 48-hr treatment. In addition, docking study was conducted to show probable ways through which phytochemicals interact with TIPs. Results: Treated and untreated hASCs had undetectable TERT expression, but they did affect the AKT1 and DKC1 expression levels (CI=0.95; P

  18. The Fu Foundation School of Engineering & Applied Science - Columbia

    Science.gov (United States)

    Engineering Mechanics Computer Science Earth and Environmental Engineering Electrical Engineering Industrial Engineering & Applied Science - Columbia University Admissions Undergraduates Graduates Distance Learning Physics and Applied Mathematics Biomedical Engineering Chemical Engineering Civil Engineering and

  19. The Idaho National Engineering Laboratory Site environmental report for calendar year 1991

    International Nuclear Information System (INIS)

    Hoff, D.L.; Mitchell, R.G.; Moore, R.; Bingham, L.

    1992-09-01

    The results of the various monitoring programs for 1991 indicate that most radioactivity from the Idaho National Engineering Laboratory (INEL) operations could not be distinguished from worldwide fallout and natural radioactivity in the region surrounding the INEL Site. Although some radioactive materials were discharged during Site operations, concentrations and doses to the surrounding population were of no health consequence and were far less than State of Idaho and Federal health protection guidelines. The first section of the report summarizes Calendar Year 1991 and January 1 through June 1, 1992, INEL activities related to compliance with environmental regulations and laws. The major portion of the report summarizes results of the RESL environmental surveillance program, which includes the collection of foodstuffs at the INEL boundary and distant offsite locations, and the collection of air and water samples at onsite locations and offsite boundary and distant locations. The report also compares and evaluates the sample results to appropriate federal regulations and standards and discusses implications, if any. The US Geological Survey (USGS) groundwater monitoring program is briefly summarized and data from USGS reports are included in tables and maps showing the spread of contaminants. Effluent monitoring and nonradiological drinking water monitoring performed by INEL contractors are discussed briefly and data are summarized in tables

  20. HEMISPHERIC CENTER FOR ENVIRONMENTAL TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian

    1999-03-30

    A vendor was selected for the diamond wire technology demonstration scheduled for this summer at Princeton Plasma Physics Laboratory (PPPL). A team consisting of personnel from FIU-HCET, PPPL, and AEA Technology reviewed the submitted bids. FIU-HCET will contract this vendor. At the SRS Ninth ICT teleconference, the ICT team discussed the status of the following demonstrations: LRAD; x-ray, K-edge; Strippable Coatings; Thermal Spray Vitrification; Cutting/Shearing/Dismantlement/Size Reduction; and Electrets. The LRAD demo is complete, and the x-ray/K-edge, Strippable Coatings, and Electrets demos are ongoing. The Asbestos and Thermal Spray Vitrification demos require more laboratory testing. The Cutting/Shearing/Dismantlement/Size Reduction demo is undergoing procurement. Five FIU-HCET staff members took the 1S0 14000 environmental auditor training course February 22-26, 1999, given by ASC. The test plan for the Facility Dismantlement Technology Assessment is finished and ready for internal review.

  1. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement. Volume 2, Part B

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    Two types of projects in the spent nuclear fuel and environmental restoration and waste management activities at the Idaho National Engineering Laboratory (INEL) are described. These are: foreseeable proposed projects where some funding for preliminary planning and/or conceptual design may already be authorized, but detailed design or planning will not begin until the Department of Energy (DOE) has determined that the requirements of the National Environmental Policy Act process for the project have been completed; planned or ongoing projects not yet completed but whose National Environmental Policy Act documentation is already completed or is expected to be completed before the Record of Decision for this Envirorunental Impact Statement (EIS) is issued. The section on project summaries describe the projects (both foreseeable proposed and ongoing).They provide specific information necessary to analyze the environmental impacts of these projects. Chapter 3 describes which alternative(s) each project supports. Summaries are included for (a) spent nuclear fuel projects, (b) environmental remediation projects, (c) the decontamination and decommissioning of surplus INEL facilities, (d) the construction, upgrade, or replacement of existing waste management facilities, (e) infrastructure projects supporting waste management activities, and (f) research and development projects supporting waste management activities.

  2. The Cladophora glomerata Enriched by Biosorption Process in Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem Cells (ASCs) and Their Extracellular Vesicles (MV's).

    Science.gov (United States)

    Marycz, Krzysztof; Michalak, Izabela; Kocherova, Ievgeniia; Marędziak, Monika; Weiss, Christine

    2017-12-08

    This study investigated in vitro effects of freshwater alga Cladophora glomerata water extract enriched during a biosorption process in Cr(III) trivalent chromium and chromium picolinate on adipose-derived mesenchymal stromal stem cells (ASCs) and extracellular microvesicles (MVs) in equine metabolic syndrome-affected horses. Chemical characterisation of natural Cladophora glomerata was performed with special emphasis on: vitamin C, vitamin E, total phenols, fatty acids, free and protein-bound amino acids as well as measured Cr in algal biomass. To examine the influence of Cladophora glomerata water extracts, in vitro viability, oxidative stress factor accumulation, apoptosis, inflammatory response, biogenesis of mitochondria, autophagy in ASCs of EMS and secretory activity manifested by MV release were investigated. For this purpose, various methods of molecular biology and microscopic observations (i.e., immunofluorescence staining, SEM, TEM, FIB observations, mRNA and microRNA expression by RT-qPCR) were applied. The extract of Cladophora glomerata enriched with Cr(III) ions reduced apoptosis and inflammation in ASCs of EMS horses through improvement of mitochondrial dynamics, decreasing of PDK4 expression and reduction of endoplastic reticulum stress. Moreover, it was found, that Cladophora glomerata and Cr(III) induce antioxidative protection coming from enhanced SOD activity Therefore, Cladophora glomerata enriched with Cr(III) ions might become an interesting future therapeutic agent in the pharmacological treatment of EMS horses.

  3. 40 CFR 1045.330 - May I sell engines from an engine family with a suspended certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false May I sell engines from an engine... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.330 May I sell engines from an...

  4. Supplemental investigations in support of environmental assessments by the Idaho INEL Oversight Program at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    1992-01-01

    This document reports on the status of supplemental investigations in support of environmental assessments by the Idaho INEL Oversight Program at the Idaho National Engineering Laboratory. Included is information on hydrology studies in wells open through large intervals, unsaturated zone contamination and transport processes, surface water-groundwater interactions, regional groundwater flow, and independent testing of air quality data

  5. In Vivo and In Vitro Study of a Polylactide-Fiber-Reinforced β-Tricalcium Phosphate Composite Cage in an Ovine Anterior Cervical Intercorporal Fusion Model

    Directory of Open Access Journals (Sweden)

    Janek Frantzén

    2011-01-01

    Full Text Available A poly-70L/30DL-lactide (PLA70–β-tricalcium phosphate (β-TCP composite implant reinforced by continuous PLA-96L/4D-lactide (PLA96 fibers was designed for in vivo spinal fusion. The pilot study was performed with four sheep, using titanium cage implants as controls. The composite implants failed to direct bone growth as desired, whereas the bone contact and the proper integration were evident with controls 6 months after implantation. Therefore, the PLA70/β-TCP composite matrix material was further analyzed in the in vitro experiment by human and ovine adipose stem cells (hASCs and oASCs. The composites proved to be biocompatible as confirmed by live/dead assay. The proliferation rate of oASCs was higher than that of hASCs at all times during the 28 d culture period. Furthermore, the composites had only a minor osteogenic effect on oASCs, whereas the hASC osteogenesis on PLA70/β-TCP composites was evident. In conclusion, the composite implant material can be applied with hASCs for tissue engineering but not be evaluated in vivo with sheep.

  6. Engineering Evaluation/Cost Analysis for Decommissioning of the Engineering Test Reactor Complex

    International Nuclear Information System (INIS)

    A. B. Culp

    2006-01-01

    Preparation of this Engineering Evaluation/Cost Analysis is consistent with the joint U.S. Department of Energy and U.S. Environmental Protection Agency Policy on Decommissioning of Department of Energy Facilities Under the Comprehensive Environmental Response, Compensation, and Liability Act, which establishes the Comprehensive Environmental Response, Compensation, and Liability Act non-time-critical removal action (NTCRA) process as an approach for decommissioning

  7. Engineering Evaluation/Cost Analysis for Decommissioning of the Engineering Test Reactor Complex

    Energy Technology Data Exchange (ETDEWEB)

    A. B. Culp

    2006-10-01

    Preparation of this Engineering Evaluation/Cost Analysis is consistent with the joint U.S. Department of Energy and U.S. Environmental Protection Agency Policy on Decommissioning of Department of Energy Facilities Under the Comprehensive Environmental Response, Compensation, and Liability Act, which establishes the Comprehensive Environmental Response, Compensation, and Liability Act non-time-critical removal action (NTCRA) process as an approach for decommissioning.

  8. Intelligent environmental data warehouse

    International Nuclear Information System (INIS)

    Ekechukwu, B.

    1998-01-01

    Making quick and effective decisions in environment management are based on multiple and complex parameters, a data warehouse is a powerful tool for the over all management of massive environmental information. Selecting the right data from a warehouse is an important factor consideration for end-users. This paper proposed an intelligent environmental data warehouse system. It consists of data warehouse to feed an environmental researchers and managers with desire environmental information needs to their research studies and decision in form of geometric and attribute data for study area, and a metadata for the other sources of environmental information. In addition, the proposed intelligent search engine works according to a set of rule, which enables the system to be aware of the environmental data wanted by the end-user. The system development process passes through four stages. These are data preparation, warehouse development, intelligent engine development and internet platform system development. (author)

  9. Pre-engineering Spaceflight Validation of Environmental Models and the 2005 HZETRN Simulation Code

    Science.gov (United States)

    Nealy, John E.; Cucinotta, Francis A.; Wilson, John W.; Badavi, Francis F.; Dachev, Ts. P.; Tomov, B. T.; Walker, Steven A.; DeAngelis, Giovanni; Blattnig, Steve R.; Atwell, William

    2006-01-01

    The HZETRN code has been identified by NASA for engineering design in the next phase of space exploration highlighting a return to the Moon in preparation for a Mars mission. In response, a new series of algorithms beginning with 2005 HZETRN, will be issued by correcting some prior limitations and improving control of propagated errors along with established code verification processes. Code validation processes will use new/improved low Earth orbit (LEO) environmental models with a recently improved International Space Station (ISS) shield model to validate computational models and procedures using measured data aboard ISS. These validated models will provide a basis for flight-testing the designs of future space vehicles and systems of the Constellation program in the LEO environment.

  10. The Cladophora glomerata Enriched by Biosorption Process in Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem Cells (ASCs) and Their Extracellular Vesicles (MV’s)

    Science.gov (United States)

    Marycz, Krzysztof; Marędziak, Monika; Weiss, Christine

    2017-01-01

    This study investigated in vitro effects of freshwater alga Cladophora glomerata water extract enriched during a biosorption process in Cr(III) trivalent chromium and chromium picolinate on adipose-derived mesenchymal stromal stem cells (ASCs) and extracellular microvesicles (MVs) in equine metabolic syndrome-affected horses. Chemical characterisation of natural Cladophora glomerata was performed with special emphasis on: vitamin C, vitamin E, total phenols, fatty acids, free and protein-bound amino acids as well as measured Cr in algal biomass. To examine the influence of Cladophora glomerata water extracts, in vitro viability, oxidative stress factor accumulation, apoptosis, inflammatory response, biogenesis of mitochondria, autophagy in ASCs of EMS and secretory activity manifested by MV release were investigated. For this purpose, various methods of molecular biology and microscopic observations (i.e., immunofluorescence staining, SEM, TEM, FIB observations, mRNA and microRNA expression by RT-qPCR) were applied. The extract of Cladophora glomerata enriched with Cr(III) ions reduced apoptosis and inflammation in ASCs of EMS horses through improvement of mitochondrial dynamics, decreasing of PDK4 expression and reduction of endoplastic reticulum stress. Moreover, it was found, that Cladophora glomerata and Cr(III) induce antioxidative protection coming from enhanced SOD activity Therefore, Cladophora glomerata enriched with Cr(III) ions might become an interesting future therapeutic agent in the pharmacological treatment of EMS horses. PMID:29292726

  11. The Cladophora glomerata Enriched by Biosorption Process in Cr(III Improves Viability, and Reduces Oxidative Stress and Apoptosis in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem Cells (ASCs and Their Extracellular Vesicles (MV’s

    Directory of Open Access Journals (Sweden)

    Krzysztof Marycz

    2017-12-01

    Full Text Available This study investigated in vitro effects of freshwater alga Cladophora glomerata water extract enriched during a biosorption process in Cr(III trivalent chromium and chromium picolinate on adipose-derived mesenchymal stromal stem cells (ASCs and extracellular microvesicles (MVs in equine metabolic syndrome-affected horses. Chemical characterisation of natural Cladophora glomerata was performed with special emphasis on: vitamin C, vitamin E, total phenols, fatty acids, free and protein-bound amino acids as well as measured Cr in algal biomass. To examine the influence of Cladophora glomerata water extracts, in vitro viability, oxidative stress factor accumulation, apoptosis, inflammatory response, biogenesis of mitochondria, autophagy in ASCs of EMS and secretory activity manifested by MV release were investigated. For this purpose, various methods of molecular biology and microscopic observations (i.e., immunofluorescence staining, SEM, TEM, FIB observations, mRNA and microRNA expression by RT-qPCR were applied. The extract of Cladophora glomerata enriched with Cr(III ions reduced apoptosis and inflammation in ASCs of EMS horses through improvement of mitochondrial dynamics, decreasing of PDK4 expression and reduction of endoplastic reticulum stress. Moreover, it was found, that Cladophora glomerata and Cr(III induce antioxidative protection coming from enhanced SOD activity Therefore, Cladophora glomerata enriched with Cr(III ions might become an interesting future therapeutic agent in the pharmacological treatment of EMS horses.

  12. Preliminary Waste Form Compliance Plan for the Idaho National Engineering and Environmental Laboratory High-Level Waste

    Energy Technology Data Exchange (ETDEWEB)

    B. A. Staples; T. P. O' Holleran

    1999-05-01

    The Department of Energy (DOE) has specific technical and documentation requirements for high-level waste (HLW) that is to be placed in a federal repository. This document describes in general terms the strategy to be used at the Idaho National Engineering and Environmental Laboratory (INEEL) to demonstrate that vitrified HLW, if produced at the INEEL, meets these requirements. Waste form, canister, quality assurance, and documentation specifications are discussed. Compliance strategy is given, followed by an overview of how this strategy would be implemented for each specification.

  13. Preliminary Waste Form Compliance Plan for the Idaho National Engineering and Environmental Laboratory High-Level Waste

    International Nuclear Information System (INIS)

    Staples, B. A.; O'Holleran, T. P.

    1999-01-01

    The Department of Energy (DOE) has specific technical and documentation requirements for high-level waste (HLW) that is to be placed in a federal repository. This document describes in general terms the strategy to be used at the Idaho National Engineering and Environmental Laboratory (INEEL) to demonstrate that vitrified HLW, if produced at the INEEL, meets these requirements. Waste form, canister, quality assurance, and documentation specifications are discussed. Compliance strategy is given, followed by an overview of how this strategy would be implemented for each specification

  14. Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses

    Science.gov (United States)

    Christo, Susan N.; Diener, Kerrilyn R.; Manavis, Jim; Grimbaldeston, Michele A.; Bachhuka, Akash; Vasilev, Krasimir; Hayball, John D.

    2016-01-01

    Detailing the inflammatory mechanisms of biomaterial-implant induced foreign body responses (FBR) has implications for revealing targetable pathways that may reduce leukocyte activation and fibrotic encapsulation of the implant. We have adapted a model of poly(methylmethacrylate) (PMMA) bead injection to perform an assessment of the mechanistic role of the ASC-dependent inflammasome in this process. We first demonstrate that ASC−/− mice subjected to PMMA bead injections had reduced cell infiltration and altered collagen deposition, suggesting a role for the inflammasome in the FBR. We next investigated the NLRP3 and AIM2 sensors because of their known contributions in recognising damaged and apoptotic cells. We found that NLRP3 was dispensable for the fibrotic encapsulation; however AIM2 expression influenced leukocyte infiltration and controlled collagen deposition, suggesting a previously unexplored link between AIM2 and biomaterial-induced FBR. PMID:26860464

  15. INL Site Portion of the April 1995 Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Mamagement Programmatic Final Environmental Impact Statement

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    2005-06-30

    In April 1995, the Department of Energy (DOE) and the Department of the Navy, as a cooperating agency, issued the Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Final Environmental Impact Statement (1995 EIS). The 1995 EIS analyzed alternatives for managing The Department's existing and reasonably foreseeable inventories of spent nuclear fuel through the year 2035. It also included a detailed analysis of environmental restoration and waste management activities at the Idaho National Engineering and Environmental Laboratory (INEEL). The analysis supported facility-specific decisions regarding new, continued, or planned environmental restoration and waste management operations. The Record of Decision (ROD) was signed in June 1995 and amended in February 1996. It documented a number of projects or activities that would be implemented as a result of decisions regarding INL Site operations. In addition to the decisions that were made, decisions on a number of projects were deferred or projects have been canceled. DOE National Environmental Policy Act (NEPA) implementing procedures (found in 10 CFR Part 1 021.330(d)) require that a Supplement Analysis of site-wide EISs be done every five years to determine whether the site-wide EIS remains adequate. While the 1995 EIS was not a true site-wide EIS in that several programs were not included, most notably reactor operations, this method was used to evaluate the adequacy of the 1995 EIS. The decision to perform a Supplement Analysis was supported by the multi-program aspect of the 1995 EIS in conjunction with the spirit of the requirement for periodic review. The purpose of the SA is to determine if there have been changes in the basis upon which an EIS was prepared. This provides input for an evaluation of the continued adequacy of the EIS in light of those changes (i.e., whether there are substantial changes in the proposed

  16. Procedures | College of Engineering & Applied Science

    Science.gov (United States)

    Biomedical Engineering Industry Advisory Council Civil & Environmental Engineering Civil & . pirating software, music, movies or hacking) will be referred directly to the University Police. I feel I

  17. Cost-time management for environmental restoration activities at the Department of Energy's Idaho National Engineering Laboratory, Idaho Chemical Processing Plant

    International Nuclear Information System (INIS)

    Fourr, B.R.; Owen, A.H.; Williamson, D.J.; Nash, C.L.

    1992-01-01

    Cost-time management methods have been developed by Westinghouse to examine business applications from a cost-time perspective. The initial application of cost-time management within Westinghouse was targeted at reducing cycle time in the manufacturing sector. As a result of the tremendous success of reduced cycle time in manufacturing, Westinghouse initiated application of the management technique to Environmental Restoration activities at its Government Owned Contractor Operated facilities. The Westinghouse initiative was proposed in support of the Department of Energy's goals for cost effective Environmental Restoration activities. This paper describes the application of the cost-time method to Environmental Restoration work currently being performed at the Idaho National Engineering Laboratory (INEL) for the Department of Energy (DOE) by Westinghouse Idaho Nuclear Company (WINCO)

  18. Influência da embalagem de atmosfera modificada e do tratamento com cálcio na cinética de degradação de ácido ascórbico e perda de massa em goiabas (Psidium guajava L.

    Directory of Open Access Journals (Sweden)

    YAMASHITA Fábio

    2000-01-01

    Full Text Available Goiabas de mesa (var. Pedro Sato no estádio verde maturo foram armazenadas a 8°C (85-95% UR por 49 dias. Uma parte das amostras foi tratada com solução de cloreto de cálcio 2% (p/v e o restante permaneceu sem tratamento. Posteriormente, foram embaladas individualmente em dois tipos de embalagem de atmosfera modificada (CryovacÒ PD-900 e CryovacÒ PD-961. Goiabas sem embalagem e não tratadas com cálcio, mantidas à mesma temperatura de 8°C serviram como controle. Foram realizadas análises de perda de massa, acidez titulável, teores de sólidos solúveis totais e ácido ascórbico. Os frutos embalados apresentaram taxas de perda de massa menores que os sem embalagem (p<0,05. Os frutos tratados com cálcio não apresentaram diferença na taxa de degradação de ácido ascórbico em relação aos não tratados e os frutos embalados com PD-900 apresentaram retenção de ácido ascórbico maior. Após 4 semanas, as goiabas sem embalagem apresentaram-se impróprias para consumo, devido ao murchamento e ataque de fungos, enquanto que as embaladas estavam em bom estado. Após a sexta semana, apenas os frutos embalados com PD-900 sem tratamento com cálcio estavam próprios para consumo. A embalagem de atmosfera modificada reduziu a perda de massa e ácido ascórbico e prolongou a vida-de-prateleira do produto. O emprego de cálcio não afetou as características analisadas.

  19. EnviroTech: Enhancing Environmental Literacy and Technology Assessment Skills

    Science.gov (United States)

    Rose, Mary Annette

    2010-01-01

    It is no coincidence that many of the "Grand Challenges for Engineering" (National Academy of Engineering, 2007-2010)--such as carbon sequestration--address environmental problems that were precipitated by human inventiveness and engineering achievements. Although people recognize their dependence upon environmental processes to provide…

  20. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs, Draft Environmental Impact Statement

    International Nuclear Information System (INIS)

    1994-06-01

    Volume 1 to the Department of Energy's Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Management Programs Environmental Impact Statement evaluates a range of alternatives for managing naval spent nuclear fuel expected to be removed from US Navy nuclear-powered vessels and prototype reactors through the year 2035. The Environmental Impact Statement (EIS) considers a range of alternatives for examining and storing naval spent nuclear fuel, including alternatives that terminate examination and involve storage close to the refueling or defueling site. The EIS covers the potential environmental impacts of each alternative, as well as cost impacts and impacts to the Naval Nuclear Propulsion Program mission. This Appendix covers aspects of the alternatives that involve managing naval spent nuclear fuel at four naval shipyards and the Naval Nuclear Propulsion Program Kesselring Site in West Milton, New York. This Appendix also covers the impacts of alternatives that involve examining naval spent nuclear fuel at the Expended Core Facility in Idaho and the potential impacts of constructing and operating an inspection facility at any of the Department of Energy (DOE) facilities considered in the EIS. This Appendix also considers the impacts of the alternative involving limited spent nuclear fuel examinations at Puget Sound Naval Shipyard. This Appendix does not address the impacts associated with storing naval spent nuclear fuel after it has been inspected and transferred to DOE facilities. These impacts are addressed in separate appendices for each DOE site

  1. Environmental, health, and safety effects of engineered nanomaterials: challenges and research needs

    Science.gov (United States)

    Fairbrother, Howard

    2010-04-01

    The number of technologies and consumer products that incorporate engineered nanomaterials (ENMs) has grown rapidly. Indeed, ENMs such as carbon nanotubes and nano-silver, are revolutionizing many commercial technologies and have already been incorporated into more than 800 commercial products, including polymer composites, cell phone batteries, sporting equipment and cosmetics. The global market for ENMs has grown steadily from 7.5 billion in 2003 to 12.7 billion in 2008. Over the next five years, their market value is expected to exceed $27 billion. This surge in demand has been responsible for a corresponding increase in the annual production rates of ENMs. For example, Bayer anticipates that single and multi-walled carbon nanotubes (SWNT and MWNT) production rates will reach 3,000 tons/yr by 2012. Inevitably, some of these synthetic materials will enter the environment either from incidental release during manufacture and transport, or following use and disposal. Consequently, intense scientific research is now being directed towards understanding the environmental, health and safety (EHS) risks posed by ENMs. I will highlight some of the key research challenges and needs in this area, include (i) developing structure-property relationships that will enable physicochemical properties of ENMs to be correlated with environmentally relevant behavior (e.g. colloidal properties, toxicity), (ii) determining the behavior of nanoproducts, and (iii) developing analytical techniques capable of detecting and quantifying the concentration of ENMs in the environment.

  2. Computational modeling for eco engineering: Making the connections between engineering and ecology (Invited)

    Science.gov (United States)

    Bowles, C.

    2013-12-01

    Ecological engineering, or eco engineering, is an emerging field in the study of integrating ecology and engineering, concerned with the design, monitoring, and construction of ecosystems. According to Mitsch (1996) 'the design of sustainable ecosystems intends to integrate human society with its natural environment for the benefit of both'. Eco engineering emerged as a new idea in the early 1960s, and the concept has seen refinement since then. As a commonly practiced field of engineering it is relatively novel. Howard Odum (1963) and others first introduced it as 'utilizing natural energy sources as the predominant input to manipulate and control environmental systems'. Mtisch and Jorgensen (1989) were the first to define eco engineering, to provide eco engineering principles and conceptual eco engineering models. Later they refined the definition and increased the number of principles. They suggested that the goals of eco engineering are: a) the restoration of ecosystems that have been substantially disturbed by human activities such as environmental pollution or land disturbance, and b) the development of new sustainable ecosystems that have both human and ecological values. Here a more detailed overview of eco engineering is provided, particularly with regard to how engineers and ecologists are utilizing multi-dimensional computational models to link ecology and engineering, resulting in increasingly successful project implementation. Descriptions are provided pertaining to 1-, 2- and 3-dimensional hydrodynamic models and their use at small- and large-scale applications. A range of conceptual models that have been developed to aid the in the creation of linkages between ecology and engineering are discussed. Finally, several case studies that link ecology and engineering via computational modeling are provided. These studies include localized stream rehabilitation, spawning gravel enhancement on a large river system, and watershed-wide floodplain modeling of

  3. Environmental optimisation of natural gas fired engines. Measurement on four different engines. Project report

    Energy Technology Data Exchange (ETDEWEB)

    Kvist, T.

    2010-10-15

    The emissions of NO{sub x}, CO and UHC as well as the composition of the hydrocarbon emissions were measured for four different stationary lean burn natural gas fired engines installed at different combined heat and power (CHP) units in Denmark. The units have been chosen to be representative for the natural gas engine based on power production in Denmark. The NO{sub x} emissions were varied from around 200 to 500 mg/m3(n) by varying the ignition timing and the excess of air. For each of the examined engines measurements were conducted at different combinations of ignition timing and excess of air. The measurements showed the NO{sub x} emissions were relatively more sensitive to engine setting than UHC, CO and formaldehyde emissions. By reducing the NO{sub x} emissions to 40 % of the initial value (from 500 to 200 mg/m3(n)) the UHC emission were increased by 10 % to 50 % of the initial value. The electrical efficiency was reduced by 0,5 to 1,0 % point. (Author)

  4. Chemistry for environmental scientists

    International Nuclear Information System (INIS)

    Moeller, Detlev

    2015-01-01

    Non-chemists in environmental sciences and engineering (e.g. physicists, biologists, ecologists, geographers, soil scientists, hydrologists, meteorologists, economists, engineers) need chemical basic knowledge for understanding chemical processes in the environment. This book focuses on general and fundamental chemistry (including required physics) such as properties and bonding of matter, chemical kinetics and mechanisms, phase and chemical equilibrium, the basic features of air (gases), water (liquids) and soil (solids) and the most important substances and their reactions in the environment. Selected key environmental chemical processes are shortly characterised in the light of multi-component and multiphase chemistry. This book is also useful for chemists who are beginning work on environmental issues.

  5. Chemistry for environmental scientists

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, Detlev [Brandenburgische Technische Univ., Berlin (Germany). Lehrstuhl fuer Luftchemie und Luftreinhaltung

    2015-07-01

    Non-chemists in environmental sciences and engineering (e.g. physicists, biologists, ecologists, geographers, soil scientists, hydrologists, meteorologists, economists, engineers) need chemical basic knowledge for understanding chemical processes in the environment. This book focuses on general and fundamental chemistry (including required physics) such as properties and bonding of matter, chemical kinetics and mechanisms, phase and chemical equilibrium, the basic features of air (gases), water (liquids) and soil (solids) and the most important substances and their reactions in the environment. Selected key environmental chemical processes are shortly characterised in the light of multi-component and multiphase chemistry. This book is also useful for chemists who are beginning work on environmental issues.

  6. Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC adipocytes.

    Directory of Open Access Journals (Sweden)

    Darwin V Lee

    Full Text Available Fibroblast growth factor 21 (FGF21 has evolved as a major metabolic regulator, the pharmacological administration of which causes weight loss, insulin sensitivity and glucose control in rodents and humans. To understand the molecular mechanisms by which FGF21 exerts its metabolic effects, we developed a human in vitro model of adipocytes to examine crosstalk between FGF21 and insulin signaling. Human adipose stem cell-derived (hASC adipocytes were acutely treated with FGF21 alone, insulin alone, or in combination. Insulin signaling under these conditions was assessed by measuring tyrosine phosphorylation of insulin receptor (InsR, insulin receptor substrate-1 (IRS-1, and serine 473 phosphorylation of Akt, followed by a functional assay using 14C-2-deoxyglucose [14C]-2DG to measure glucose uptake in these cells. FGF21 alone caused a modest increase of glucose uptake, but treatment with FGF21 in combination with insulin had a synergistic effect on glucose uptake in these cells. The presence of FGF21 also effectively lowered the insulin concentration required to achieve the same level of glucose uptake compared to the absence of FGF21 by 10-fold. This acute effect of FGF21 on insulin signaling was not due to IR, IGF-1R, or IRS-1 activation. Moreover, we observed a substantial increase in basal S473-Akt phosphorylation by FGF21 alone, in contrast to the minimal shift in basal glucose uptake. Taken together, our data demonstrate that acute co-treatment of hASC-adipocytes with FGF21 and insulin can result in a synergistic improvement in glucose uptake. These effects were shown to occur at or downstream of Akt, or separate from the canonical insulin signaling pathway.

  7. Advancing Environmental Education and Training for Sustainable Management of Environmental Resources in Palestine

    Science.gov (United States)

    Al-Sa'ed, Rashed; Abu-Madi, Maher; Heun, Jetze

    2009-01-01

    This article describes the various capacity-building activities at the Institute of Environmental and Water Studies of Birzeit University during the past 10 years. It highlights the gained experience in advancing environmental science and engineering education and training programs as components of sustainable water and environmental management…

  8. THE HUMANIST FORMATION OF THE AGRONOMIST ENGINEER THROUGH THE ENVIRONMENTAL EDUCATION / LA FORMACIÓN HUMANISTA DEL INGENIERO AGRÓNOMO A TRAVÉS DE LA EDUCACIÓN AMBIENTAL

    Directory of Open Access Journals (Sweden)

    Adelaida Almaguer Álvarez

    2010-10-01

    Full Text Available To guide the formation of the agronomist professionals towards and for the environment, as a complex and multidimensional objective means to system and integrate contents of the natural, techniques and social sciences; this will allow, with a holistic thought, to deal with the environmental problematic, from a point of view that goes beyond the ecological and technological processes and integrates social and cultural processes. The creation of a humanist behavior and the acquisition of ethic convictions in an agronomist engineer require for the establishment of strategies, models and a good environmental practice that, from their own process of formation, will contribute to the integration to the sociocultural and humanist dimensions in the Environmental Education. In this sense the investigation offers a strategy for the humanist formation of the agronomist engineer; which is supported by the integration of the Environmental Education to the process of general formation of this professional, thorough the components and dimensions of such a process.

  9. Metabolic network modeling of microbial interactions in natural and engineered environmental systems

    Directory of Open Access Journals (Sweden)

    Octavio ePerez-Garcia

    2016-05-01

    Full Text Available We review approaches to characterize metabolic interactions within microbial communities using Stoichiometric Metabolic Network (SMN models for applications in environmental and industrial biotechnology. SMN models are computational tools used to evaluate the metabolic engineering potential of various organisms. They have successfully been applied to design and optimize the microbial production of antibiotics, alcohols and amino acids by single strains. To date however, such models have been rarely applied to analyze and control the metabolism of more complex microbial communities. This is largely attributed to the diversity of microbial community functions, metabolisms and interactions. Here, we firstly review different types of microbial interaction and describe their relevance for natural and engineered environmental processes. Next, we provide a general description of the essential methods of the SMN modeling workflow including the steps of network reconstruction, simulation through Flux Balance Analysis (FBA, experimental data gathering, and model calibration. Then we broadly describe and compare four approaches to model microbial interactions using metabolic networks, i.e. i lumped networks, ii compartment per guild networks, iii bi-level optimization simulations and iv dynamic-SMN methods. These approaches can be used to integrate and analyze diverse microbial physiology, ecology and molecular community data. All of them (except the lumped approach are suitable for incorporating species abundance data but so far they have been used only to model simple communities of two to eight different species. Interactions based on substrate exchange and competition can be directly modeled using the above approaches. However, interactions based on metabolic feedbacks, such as product inhibition and synthropy require extensions to current models, incorporating gene regulation and compounding accumulation mechanisms. SMN models of microbial

  10. Baseline Flowsheet Generation for the Treatment and Disposal of Idaho National Engineering and Environmental Laboratory Sodium Bearing Waste

    International Nuclear Information System (INIS)

    Barnes, C.M.; Lauerhass, L.; Olson, A.L.; Taylor, D.D.; Valentine, J.H.; Lockie, K.A.

    2002-01-01

    The High-Level Waste (HLW) Program at the Idaho National Engineering and Environmental Laboratory (INEEL) must implement technologies and processes to treat and qualify radioactive wastes located at the Idaho Nuclear Technology and Engineering Center (INTEC) for permanent disposal. This paper describes the approach and accomplishments to date for completing development of a baseline vitrification treatment flowsheet for sodium-bearing waste (SBW), including development of a relational database used to manage the associated process assumptions. A process baseline has been developed that includes process requirements, basis and assumptions, process flow diagrams, a process description, and a mass balance. In the absence of actual process or experimental results, mass and energy balance data for certain process steps are based on assumptions. Identification, documentation, validation, and overall management of the flowsheet assumptions are critical to ensuring an integrated, focused program. The INEEL HLW Program initially used a roadmapping methodology, developed through the INEEL Environmental Management Integration Program, to identify, document, and assess the uncertainty and risk associated with the SBW flowsheet process assumptions. However, the mass balance assumptions, process configuration and requirements should be accessible to all program participants. This need resulted in the creation of a relational database that provides formal documentation and tracking of the programmatic uncertainties related to the SBW flowsheet

  11. The role of environmental factors in regulating the development of cartilaginous grafts engineered using osteoarthritic human infrapatellar fat pad-derived stem cells.

    Science.gov (United States)

    Liu, Yurong; Buckley, Conor T; Downey, Richard; Mulhall, Kevin J; Kelly, Daniel J

    2012-08-01

    Engineering functional cartilaginous grafts using stem cells isolated from osteoarthritic human tissue is of fundamental importance if autologous tissue engineering strategies are to be used in the treatment of diseased articular cartilage. It has previously been demonstrated that human infrapatellar fat pad (IFP)-derived stem cells undergo chondrogenesis in pellet culture; however, the ability of such cells to generate functional cartilaginous grafts has not been adequately addressed. The objective of this study was to explore how environmental conditions regulate the functional development of cartilaginous constructs engineered using diseased human IFP-derived stem cells (FPSCs). FPSCs were observed to display a diminished chondrogenic potential upon encapsulation in a three-dimensional hydrogel compared with pellet culture, synthesizing significantly lower levels of glycosaminoglycan and collagen on a per cell basis. To engineer more functional cartilaginous grafts, we next explored whether additional biochemical and biophysical stimulations would enhance chondrogenesis within the hydrogels. Serum stimulation was observed to partially recover the diminished chondrogenic potential within hydrogel culture. Over 42 days, stem cells that had first been expanded in a low-oxygen environment proliferated extensively on the outer surface of the hydrogel in response to serum stimulation, assembling a dense type II collagen-positive cartilaginous tissue resembling that formed in pellet culture. The application of hydrostatic pressure did not further enhance extracellular matrix synthesis within the hydrogels, but did appear to alter the spatial accumulation of extracellular matrix leading to the formation of a more compact tissue with superior mechanically functionality. Further work is required in order to recapitulate the environmental conditions present during pellet culture within scaffolds or hydrogels in order to engineer more functional cartilaginous grafts using

  12. 40 CFR 1065.510 - Engine mapping.

    Science.gov (United States)

    2010-07-01

    ....510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS... the atmospheric pressure near the engine's air inlet is not within ± 5 kPa of the atmospheric pressure recorded at the time of the last engine map. (3) If the engine or emission-control system has undergone...

  13. Fernald Environmental Management Project 1995 site environmental report

    International Nuclear Information System (INIS)

    1996-06-01

    The Fernald site continues to examine the air and liquid pathways as possible routes through which pollutants from past operations and current remedial activities may leave the site. This 1995 Site Environmental Report provides the general public as well as scientists and engineers with the results from the site's ongoing Environmental Monitoring Program. Also included in this report is information concerning the site's progress toward achieving full compliance with requirements set forth by DOE, US Environmental Protection Agency (USEPA), and Ohio EPA

  14. Environmental Impact Assessment: A Procedure.

    Science.gov (United States)

    Stover, Lloyd V.

    Prepared by a firm of consulting engineers, this booklet outlines the procedural "whys and hows" of assessing environmental impact, particularly for the construction industry. Section I explores the need for environmental assessment and evaluation to determine environmental impact. It utilizes a review of the National Environmental Policy Act and…

  15. Synthesis of biomass derived carbon materials for environmental engineering and energy storage applications

    Science.gov (United States)

    Huggins, Mitchell Tyler

    Biomass derived carbon (BC) can serve as an environmentally and cost effective material for both remediation and energy production/storage applications. The use of locally derived biomass, such as unrefined wood waste, provides a renewable feedstock for carbon material production compared to conventional unrenewable resources like coal. Additionally, energy and capital cost can be reduced through the reduction in transport and processing steps and the use of spent material as a soil amendment. However, little work has been done to evaluate and compare biochar to conventional materials such as granular activated carbon or graphite in advanced applications of Environmental Engineering. In this work I evaluated the synthesis and compared the performance of biochar for different applications in wastewater treatment, nutrient recovery, and energy production and storage. This includes the use of biochar as an electrode and filter media in several bioelectrochemical systems (BES) treating synthetic and industrial wastewater. I also compared the treatment efficiency of granular biochar as a packed bed adsorbent for the primary treatment of high strength brewery wastewater. My studies conclude with the cultivation of fungal biomass to serve as a template for biochar synthesis, controlling the chemical and physical features of the feedstock and avoiding some of the limitations of waste derived materials.

  16. Final design of a free-piston hydraulic advanced Stirling conversion system

    Science.gov (United States)

    Wallace, D. A.; Noble, J. E.; Emigh, S. G.; Ross, B. A.; Lehmann, G. A.

    1991-01-01

    Under the US Department of Energy's (DOEs) Solar Thermal Technology Program, Sandia National Laboratories is evaluating heat engines for solar distributed receiver systems. The final design is described of an engineering prototype advanced Stirling conversion system (ASCS) with a free-piston hydraulic engine output capable of delivering about 25 kW of electric power to a utility grid. The free-piston Stirling engine has the potential for a highly reliable engine with long life because it has only a few moving parts, has noncontacting bearings, and can be hermetically sealed. The ASCS is designed to deliver maximum power per year over a range of solar input with a design life of 30 years (60,000 h). The system includes a liquid Nak pool boiler heat transport system and a free-piston Stirling engine with high-pressure hydraulic output, coupled with a bent axis variable displacement hydraulic motor and a rotary induction generator.

  17. Final design of a free-piston hydraulic advanced Stirling conversion system

    Science.gov (United States)

    Wallace, D. A.; Noble, J. E.; Emigh, S. G.; Ross, B. A.; Lehmann, G. A.

    Under the US Department of Energy's (DOEs) Solar Thermal Technology Program, Sandia National Laboratories is evaluating heat engines for solar distributed receiver systems. The final design is described of an engineering prototype advanced Stirling conversion system (ASCS) with a free-piston hydraulic engine output capable of delivering about 25 kW of electric power to a utility grid. The free-piston Stirling engine has the potential for a highly reliable engine with long life because it has only a few moving parts, has noncontacting bearings, and can be hermetically sealed. The ASCS is designed to deliver maximum power per year over a range of solar input with a design life of 30 years (60,000 h). The system includes a liquid Nak pool boiler heat transport system and a free-piston Stirling engine with high-pressure hydraulic output, coupled with a bent axis variable displacement hydraulic motor and a rotary induction generator.

  18. Discussion on teaching reform of environmental planning and management

    Science.gov (United States)

    Zhang, Qiugen; Chen, Suhua; Xie, Yu; Wei, Li'an; Ding, Yuan

    2018-05-01

    The curriculum of environmental planning and management is an environmental engineering major curriculum established by the teaching steering committee of environmental science and engineering of Education Ministry, which is the core curriculum of Chinese engineering education professional certification. It plays an important role in cultivating environmental planning and environmental management ability of environmental engineering major. The selection and optimization of the course teaching content of environmental planning and management were discussed which including curriculum teaching content updating and optimizing and teaching resource system construction. The comprehensive application of teaching method was discussed which including teaching method synthesis and teaching method. The final combination of the assessment method was also discussed which including the formative assessment normal grades and the final result of the course examination. Through the curriculum comprehensive teaching reform, students' knowledge had been broadened, the subject status and autonomy of learning had been enhanced, students' learning interest had been motivated, the ability of students' finding, analyzing and solving problems had been improved. Students' innovative ability and positive spirit had been well cultivated.

  19. Bioactive effects of graphene oxide cell culture substratum on structure and function of human adipose-derived stem cells.

    Science.gov (United States)

    Kim, Jangho; Choi, Kyoung Soon; Kim, Yeonju; Lim, Ki-Tack; Seonwoo, Hoon; Park, Yensil; Kim, Deok-Ho; Choung, Pill-Hoon; Cho, Chong-Su; Kim, Soo Young; Choung, Yun-Hoon; Chung, Jong Hoon

    2013-12-01

    Nanoscale topography of artificial substrates can greatly influence the fate of stem cells including adhesion, proliferation, and differentiation. Thus the design and manipulation of nanoscale stem cell culture platforms or scaffolds are of great importance as a strategy in stem cell and tissue engineering applications. In this report, we propose that a graphene oxide (GO) film is an efficient platform for modulating structure and function of human adipose-derived stem cells (hASCs). Using a self-assembly method, we successfully coated GO on glass for fabricating GO films. The hASCs grown on the GO films showed increased adhesion, indicated by a large number of focal adhesions, and higher correlation between the orientations of actin filaments and vinculin bands compared to hASCs grown on the glass (uncoated GO substrate). It was also found that the GO films showed the stronger affinity for hASCs than the glass. In addition, the GO film proved to be a suitable environment for the time-dependent viability of hASCs. The enhanced differentiation of hASCs included osteogenesis, adipogenesis, and epithelial genesis, while chondrogenic differentiation of hASCs was decreased, compared to tissue culture polystyrene as a control substrate. The data obtained here collectively demonstrates that the GO film is an efficient substratum for the adhesion, proliferation, and differentiation of hASCs. Copyright © 2013 Wiley Periodicals, Inc., a Wiley Company.

  20. Engineering hydro's future

    International Nuclear Information System (INIS)

    Anderson, J.L.

    1992-01-01

    In this challenging hydropower market, hydropower engineering services are in high demand. The number of new hydropower projects entering the pipeline may have slowed in recent years but that does not mean work is not being done. Independent developers, utilities and municipalities are carrying out a considerable amount of hydropower activity. Whatever the work involves - preliminary planning, licensing and relicensing, environmental mitigation, plant rehabilitation or new-plant startup - engineering firms are finding a brisk market for their services. The complexity of the regulatory framework makes hydropower facility and other water resource work more important then ever. Executives of three engineering firms - Acres International, Harza Engineering and Black and Veatch - active in these areas discuss their views on the future of the hydropower engineering market

  1. Immunostaining of p16INK4a/Ki-67 and L1 Capsid Protein on Liquid-based Cytology Specimens Obtained from ASC-H and LSIL-H Cases

    OpenAIRE

    Byun, Seung Won; Lee, Ahwon; Kim, Suyeon; Choi, Yeong Jin; Lee, Youn Soo; Park, Jong Sup

    2013-01-01

    Background: Atypical squamous cell cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and low-grade intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) are ambiguous diagnostic entities for the prediction of high-grade cervical lesion. Objective and reproducible tests for predicting high-grade cervical lesions are needed to reduce unnecessary colposcopic referrals or follow-ups. Objective: We aimed to identify an adequate set of adjunctive ...

  2. Application of classic engineering techniques (value engineering and observational method) at the Weldon Spring Quarry

    International Nuclear Information System (INIS)

    Ferguson, R.D.; Valett, G.L.

    1991-01-01

    In July of 1987 the Weldon Spring quarry was listed on the Environmental Protection Agency National Priority List as the highest priority Federal facility site. The Weldon Spring Site Remedial Action Project applied the principles and techniques of Value Engineering (VE) and the Observational Method to remedial planning efforts at the quarry. VE sessions resulted in modifications of the scenarios developed during the Remedial Investigation/Feasibility Study (RM) process in preparation for conceptual design activities for the removal of waste from the quarry. The Observational Method, a technique developed to manage uncertainties, was used to guide both environmental and engineering planning to ensure that the waste removal activities win be carried out in a safe and environmentally responsible manner

  3. Enforcement management system for decommissioning project in Ningyo-toge Environmental Engineering Center. Results of activities in fiscal year 2014

    International Nuclear Information System (INIS)

    Ema, Akira; Miyagawa, Hiroshi; Ishimori, Yuu

    2016-03-01

    The Ningyo-toge Environmental Engineering Center of the Japan Atomic Energy Agency had managed the decommissioning project based on the Quality Management System and the Environmental Management System, but found that these systems were unsuitable for project management from several viewpoints. In order to solve these problems, the Task Team for Enforcement Backend Project temporarily managed the decommissioning project in 2013. To enforce the project management systematically, the Research and Development Promotion Section was organized newly in the Environmental Research and Development Department in April 2014, and started the project management. On the other hand, to establish the primary and secondary documents related to the new system, until April 2015 the section has been developing the Enforcement Management System (EMS) to separate from the Quality Management System or the Environmental Management System. This report summarizes the state of these activities in the FY 2014. Section 1 presents the introduction. Section 2 explains the procedure of the project management and its achievements. Section 3 discusses how to develop the primary and secondary documents. Section 4 concludes the new management system and further views. (author)

  4. Armored Geomembrane Cover Engineering

    Directory of Open Access Journals (Sweden)

    Kevin Foye

    2011-06-01

    Full Text Available Geomembranes are an important component of modern engineered barriers to prevent the infiltration of stormwater and runoff into contaminated soil and rock as well as waste containment facilities—a function generally described as a geomembrane cover. This paper presents a case history involving a novel implementation of a geomembrane cover system. Due to this novelty, the design engineers needed to assemble from disparate sources the design criteria for the engineering of the cover. This paper discusses the design methodologies assembled by the engineering team. This information will aid engineers designing similar cover systems as well as environmental and public health professionals selecting site improvements that involve infiltration barriers.

  5. 19th International Congress on Project Management and Engineering

    CERN Document Server

    Blanco, José; Capuz-Rizo, Salvador

    2017-01-01

    This book gathers the best papers presented at the 19th International Congress on Project Management and Engineering, which was held in Granada, Spain in July 2015. It covers a range of project management and engineering contexts, including: civil engineering and urban planning, product and process engineering, environmental engineering, energy efficiency and renewable energies, rural development, information and communication technologies, safety, labour risks and ergonomics, and training in project engineering. Project management and engineering is taking on increasing importance as projects continue to grow in size, more stakeholders become involved, and environmental, organisational and technological issues become more complex. As such, this book offers a valuable resource for all professionals seeking the latest material on the changing face of project management.

  6. Cost-time management for environmental restoration activities at the Department of Energy`s Idaho National Engineering Laboratory, Idaho Chemical Processing Plant

    Energy Technology Data Exchange (ETDEWEB)

    Fourr, B.R.; Owen, A.H.; Williamson, D.J. [Westinghouse Idaho Nuclear Co., Inc., Idaho Falls, ID (United States); Nash, C.L. [USDOE Idaho Field Office, Idaho Falls, ID (United States)

    1992-05-22

    Cost-time management methods have been developed by Westinghouse to examine business applications from a cost-time perspective. The initial application of cost-time management within Westinghouse was targeted at reducing cycle time in the manufacturing sector. As a result of the tremendous success of reduced cycle time in manufacturing, Westinghouse initiated application of the management technique to Environmental Restoration activities at its Government Owned Contractor Operated facilities. The Westinghouse initiative was proposed in support of the Department of Energy`s goals for cost effective Environmental Restoration activities. This paper describes the application of the cost-time method to Environmental Restoration work currently being performed at the Idaho National Engineering Laboratory (INEL) for the Department of Energy (DOE) by Westinghouse Idaho Nuclear Company (WINCO).

  7. Fernald Environmental Management Project 1995 site environmental report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    The Fernald site continues to examine the air and liquid pathways as possible routes through which pollutants from past operations and current remedial activities may leave the site. This 1995 Site Environmental Report provides the general public as well as scientists and engineers with the results from the site`s ongoing Environmental Monitoring Program. Also included in this report is information concerning the site`s progress toward achieving full compliance with requirements set forth by DOE, US Environmental Protection Agency (USEPA), and Ohio EPA.

  8. Regulated and unregulated emissions from highway heavy-duty diesel engines complying with U.S. Environmental Protection Agency 2007 emissions standards.

    Science.gov (United States)

    Khalek, Imad A; Bougher, Thomas L; Merritt, Patrick M; Zielinska, Barbara

    2011-04-01

    As part of the Advanced Collaborative Emissions Study (ACES), regulated and unregulated exhaust emissions from four different 2007 model year U.S. Environmental Protection Agency (EPA)-compliant heavy-duty highway diesel engines were measured on an engine dynamometer. The engines were equipped with exhaust high-efficiency catalyzed diesel particle filters (C-DPFs) that are actively regenerated or cleaned using the engine control module. Regulated emissions of carbon monoxide, nonmethane hydrocarbons, and particulate matter (PM) were on average 97, 89, and 86% lower than the 2007 EPA standard, respectively, and oxides of nitrogen (NOx) were on average 9% lower. Unregulated exhaust emissions of nitrogen dioxide (NO2) emissions were on, average 1.3 and 2.8 times higher than the NO, emissions reported in previous work using 1998- and 2004-technology engines, respectively. However, compared with other work performed on 1994- to 2004-technology engines, average emission reductions in the range of 71-99% were observed for a very comprehensive list of unregulated engine exhaust pollutants and air toxic contaminants that included metals and other elements, elemental carbon (EC), inorganic ions, and gas- and particle-phase volatile and semi-volatile organic carbon (OC) compounds. The low PM mass emitted from the 2007 technology ACES engines was composed mainly of sulfate (53%) and OC (30%), with a small fraction of EC (13%) and metals and other elements (4%). The fraction of EC is expected to remain small, regardless of engine operation, because of the presence of the high-efficiency C-DPF in the exhaust. This is different from typical PM composition of pre-2007 engines with EC in the range of 10-90%, depending on engine operation. Most of the particles emitted from the 2007 engines were mainly volatile nuclei mode in the sub-30-nm size range. An increase in volatile nanoparticles was observed during C-DPF active regeneration, during which the observed particle number was

  9. Sustainable Development in Engineering Education

    Science.gov (United States)

    Taoussanidis, Nikolaos N.; Antoniadou, Myrofora A.

    2006-01-01

    The principles and practice of environmentally and socially sustainable engineering are in line with growing community expectations and the strengthening voice of civil society in engineering interventions. Pressures towards internationalization and globalization are reflected in new course accreditation criteria and higher education structures.…

  10. Vancomycin-Resistant Enterococci (VRE) in The Intensive Care Unit in a Nonoutbreak Setting: Identification of Potential Reservoirs and Epidemiological Associations Between Patient and Environmental VRE.

    Science.gov (United States)

    McDermott, Hélène; Skally, Mairead; O'Rourke, James; Humphreys, Hilary; Fitzgerald-Hughes, Deirdre

    2018-01-01

    OBJECTIVE Among nosocomial bloodstream infections caused by enterococcal species, Ireland has the highest proportion caused by vancomycin-resistant enterococci (VRE) in Europe at 45.8%. The contribution of the near-patient environment to VRE transmission outside of outbreaks was investigated. DESIGN A prospective observational study was conducted during 7 sampling periods. METHODS Recovery of VRE isolates by swabbing the near-patient environment and patients in the intensive care unit (ICU) was conducted to identify reservoirs, clinical and molecular epidemiological associations, and the success of active surveillance cultures (ASCs). RESULTS Of 289 sampling occasions involving 157 patients and their bed spaces, VRE isolates were recovered from patient bed spaces, clinical samples, or both on 114 of 289 sampling occasions (39.4%). The patient and their bed space were positive for VRE on 34 of 114 VRE-associated sampling occasions (29.8%). Of 1,647 environment samples, 107 sites (6.5%) were VRE positive, with significantly greater VRE recovery from isolation rooms than from the open-plan area (9.1% vs 4.1%; P < .0001). The most frequently VRE-contaminated sites were the drip stand, bed control panel, and chart holders, which together accounted for 61% of contaminated sites. The use of ASCs resulted in a 172% increase in identification of VRE-colonized patients. Molecular typing revealed 2 environmental clusters, 1 cluster involving 3 patients and generally greater heterogeneity of patient isolates compared to environmental isolates. CONCLUSION Even outside of outbreaks, near-patient ICU environmental contamination with VRE is common. Better infection control policies that limit environmental transmission of VRE in the ICU and that are supported by molecular epidemiological studies, in real time, are needed. Infect Control Hosp Epidemiol 2018;39:40-45.

  11. Environmentally friendly, oil-free free piston engine. Displacement engines in distributed energy systems. Research funding decision. Subproject: Free piston engine. Final report; Ympaeistoeystaevaellinen, oeljytoen vapaamaentaemoottori. Syrjaeytysmoottoriprosessit hajautetussa energiahuollossa. Lineaarimoottori-osaprojekti. Loppuraportti

    Energy Technology Data Exchange (ETDEWEB)

    Larjola, J.; Honkatukia, J.; Sallinen, P.

    2005-07-01

    A free piston engine suitable for small-scale energy production in distributed energy systems was preliminarily designed in this project, including a manufacturing survey as well. The properties of the engine were simulated using a simulation program developed in this project, and the results were utilized in preliminary constructional design. The engine simulation program was developed by combining and modifying the source codes of the simulation and calculation programs obtained from Helsinki University of Technology, Tampere University of Technology, and Lappeenranta University of Technology. Because of the contact-free labyrinth seal used in the piston, the efficiency of the motor is about 5 percentage points lower than the efficiency of a conventional motor with oil-lubricated piston rings. On the other hand, the lack of bearing losses, and the lack of losses associated with a crankshaft system and a gearbox, as well as the lack of lubrication oil expenses, compensates this effect. As a net result, it can be estimated, that the operating expenses of this new motor could be about one percentage point lower than with a conventional motor; that is, the new motor would be slightly better than the conventional one. An oil-free free piston engine is particularly suitable for distributed energy systems using natural gas, biogas, or liquid fuel made from biomass. Because it is completely oil-free, it is very environmentally friendly, and its exhaust gases are completely free of oil residuals which are causing problems in normal gas motors. In principle the oil-free free piston engine could be used also in road vehicles which are provided with an electric power transmission system. This could enable a complete oil-free traffic system, where DME (dimethyl ether) or alcohol produced from domestic biomass would be used as a fuel. The distribution of this kind of a fuel would be easier with the present service station network than the distribution of hydrogen. Because this

  12. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs draft environmental impact statement

    International Nuclear Information System (INIS)

    1994-06-01

    The US Department of Energy (DOE) has prepared this report to assist its management in making two decisions. The first decision, which is programmatic, is to determine the management program for DOE spent nuclear fuel. The second decision is on the future direction of environmental restoration, waste management, and spent nuclear fuel management activities at the Idaho National Engineering Laboratory. Volume 1 of the EIS, which supports the programmatic decision, considers the effects of spent nuclear fuel management on the quality of the human and natural environment for planning years 1995 through 2035. DOE has derived the information and analysis results in Volume 1 from several site-specific appendixes. Volume 2 of the EIS, which supports the INEL-specific decision, describes environmental impacts for various environmental restoration, waste management, and spent nuclear fuel management alternatives for planning years 1995 through 2005. This Appendix B to Volume 1 considers the impacts on the INEL environment of the implementation of various DOE-wide spent nuclear fuel management alternatives. The Naval Nuclear Propulsion Program, which is a joint Navy/DOE program, is responsible for spent naval nuclear fuel examination at the INEL. For this appendix, naval fuel that has been examined at the Naval Reactors Facility and turned over to DOE for storage is termed naval-type fuel. This appendix evaluates the management of DOE spent nuclear fuel including naval-type fuel

  13. Evolution of project-based learning in small groups in environmental engineering courses

    Directory of Open Access Journals (Sweden)

    Jesús M. Requies

    2018-03-01

    Full Text Available This work presents the assessment of the development and evolution of an active methodology (Project-Based Learning –PBL- implemented on the course “Unit Operations in Environmental Engineering”, within the bachelor’s degree in Environmental Engineering, with the purpose of decreasing the dropout rate in this course. After the initial design and implementation of this methodology during the first academic year (12/13, different modifications were adopted in the following ones (13-14, 14-15 & 15-16 in order to optimize the student’s and professor’s work load as well as correct some malfunctions observed in the initial design of the PBL. This active methodology seeks to make students the main architects of their own learning processes. Accordingly, they have to identify their learning needs, which is a highly motivating approach both for their curricular development and for attaining the required learning outcomes in this field of knowledge. The results obtained show that working in small teams (cooperative work enhances each group member’s self–learning capabilities. Moreover, academic marks improve when compared to traditional learning methodologies. Nevertheless, the implementation of more active methodologies, such as project-based learning, in small groups has certain specific characteristics. In this case it has been implemented simultaneously in two different groups of 10 students each one. Such small groups are more heterogeneoussince the presence of two highly motivated students or not can vary or affect the whole group’s attitude and academic results.

  14. Proceedings of the 6. Banska Stiavnica Days 2004. Environmental impacts on the environment. Trends in environmental sciences and radio-environmental sciences

    International Nuclear Information System (INIS)

    Hybler, P.; Maruskova, A.

    2004-12-01

    Scientific conference deals with problems in environmental sciences and radio-environmental sciences. The conference proceeded in two sections: (A) Environmental engineering, (B) Nuclear technologies. Sixty registered people and fifty guests participated on this conference. Twenty-seven presentations and eleven posters were presented. Proceedings contain twenty-six papers from which fourteen papers deal with the scope of INIS

  15. Southern California Coastal Processes Annotated Bibliography.

    Science.gov (United States)

    1985-12-01

    05/01/71 TITLE : Avalon Transportation Wharf CITATION : Journal of Waterways, Harbors and Coastal Engineering Division, ASCE, N. Y., Vol. 97, No. WW2 ...105, No. WW2 ; ASCE, N. Y., pp. 131-147 DESCRIPTION s Effect of various offshore structures as significant barriers to normal wave progress...California, 33 pp. DESCRIPTION Infrared satellite images are shown for each of two areas near +- the California coast, Cape Mendocino and Point

  16. 1985 Environmental Monitoring Program report for the Idaho National Engineering Laboratory site

    International Nuclear Information System (INIS)

    Hoff, D.L.; Chew, E.W.; Rope, S.K.

    1986-05-01

    The results of the various monitoring programs for 1985 indicated that radioactivity from the Idaho National Engineering Laboratory (INEL) Site operations could not be distinguished from worldwide fallout and natural radioactivity in the region surrounding the Site. Although some radioactive materials were discharged during Site operations, concentrations and doses to the surrounding population were of no health consequence and were far less than State of Idaho and Federal health protection guidelines. This report describes the air, water, and foodstuff samples routinely collected at the INEL boundary locations and at locations distant from the INEL Site. It compares and evaluates the sample results, discussing implications, if any. Included for the first time this year are data from air and water samples routinely collected from onsite locations. The report also summarizes significant environmental activities at the INEL Site during 1985, nonradioactive and radioactive effluent monitoring at the Site, and the US Geological Survey (USGS) groundwater monitoring program

  17. Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids

    International Nuclear Information System (INIS)

    Kapur, S K; Wang, X; Shang, H; Yun, S; Li, X; Feng, G; Khurgel, M; Katz, A J

    2012-01-01

    Adipose-derived stromal/stem cells (ASCs) have been gaining recognition as an extremely versatile cell source for tissue engineering. The usefulness of ASCs in biofabrication is further enhanced by our demonstration of the unique properties of these cells when they are cultured as three-dimensional cellular aggregates or spheroids. As described herein, three-dimensional formulations, or self-assembling ASC spheroids develop their own extracellular matrix that serves to increase the robustness of the cells to mechanical stresses. The composition of the extracellular matrix can be altered based on the external environment of the spheroids and these constructs can be grown in a reproducible manner and to a consistent size. The spheroid formulation helps preserve the viability and developmental plasticity of ASCs even under defined, serum-free media conditions. For the first time, we show that multiple generations of adherent ASCs produced from these spheroids retain their ability to differentiate into multiple cell/tissue types. These demonstrated properties support the idea that culture-expanded ASCs are an excellent candidate cellular material for ‘organ printing’—the approach of developing complex tissue structures from a standardized cell ‘ink’ or cell formulation. (paper)

  18. Radiological Engineering: A graduate engineering - based curriculum for radiation protection

    International Nuclear Information System (INIS)

    Kearfott, K.J.; Wepfer, W.J.

    1994-01-01

    Several U.S. universities maintain formal graduate health physics curricula within their Colleges of Engineering. The term radiological engineering was coined to describe the discipline of applying engineering principles to the radiation protection aspects of nuclear technology. Radiological engineering programmes may require a specific core group of courses such as radiation biology, radiation protection practice, nuclear physics, radiation detectors, and radiation dosimetry. Students then might specialist in environmental, nuclear facilities or medical applications areas by selecting advanced courses and graduate design or research projects. In some instances the master's degree may be completed through remotely-delivered lectures. Such programmes promise to assist in educating a new group of engineering professionals dedicated to the safe utilisation of nuclear technology. The Georgis Institute of Technology's programme will serve as the specific example for this report. 8 refs., 1 fig

  19. Innovative Approach to Validation of Ultraviolet (UV) Reactors for Disinfection in Drinking Water Systems

    Science.gov (United States)

    Slide presentation at Conference: ASCE 7th Civil Engineering Conference in the Asian Region. USEPA in partnership with the Cadmus Group, Carollo Engineers, and other State & Industry collaborators, are evaluating new approaches for validating UV reactors to meet groundwater & sur...

  20. 40 CFR 35.935-18 - Value engineering.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Value engineering. 35.935-18 Section 35.935-18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... engineering. A grantee must comply with the applicable value engineering requirements of § 35.926. ...