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Sample records for asbestosis

  1. Asbestosis Asbestosis

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    B. Marín Martínez

    2005-01-01

    Full Text Available La asbestosis es una fibrosis pulmonar intersticial difusa secundaria a la inhalación de fibras de asbesto. Existe una relación dosis respuesta entre la exposición a asbesto y riesgo de desarrollar asbestosis, de tal forma que a mayor exposición, mayor riesgo de desarrollar la enfermedad. El tiempo de latencia clínica es inversamente proporcional al nivel de exposición. La disnea de esfuerzo y la tos seca junto con los crepitantes inspiratorios tardíos son los síntomas y signos más frecuentes. La radiografía de tórax constituye un instrumento básico en la identificación de la enfermedad, no obstante el TAC de alta resolución ha añadido una mayor sensibilidad. Las pruebas de función respiratoria muestran alteraciones ventilatorias restrictivas con disminución de la difusión pulmonar. La determinación de cuerpos de asbesto en BAL es un indicador de exposición aunque su ausencia no descarta enfermedad. El diagnóstico de certeza es histopatológico aunque en la mayor parte de los casos se establece el diagnóstico basándose en la existencia de antecedente de exposición a asbesto junto con hallazgos clínicos, radiológicos y funcionales sugestivos y tiempo de latencia adecuado sin recurrir a la biopsia pulmonar.Asbestosis is a diffuse interstitial pulmonary fibrosis, secondary to the inhalation of asbestos fibres. There is a dose-response relationship between exposure to asbestos and the risk of developing asbestosis, in such a way that the greater the exposure, the greater the risk of developing the disease. The time of clinical latency is inversely proportional to the level of exposure. Dyspnoea upon exertion and a dry cough together with end-inspiratory crackles are the most frequent symptoms and signs. Chest radiography is a basic tool in identifying the disease, however high resolution CAT has added greater sensitivity. Tests of the respiratory function show alterations and restrictive ventilations with a reduction of

  2. Radiologic diagnosis of asbestosis in Korea

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    Cha, Yoon Ki; Kim, Jeung Sook [Dept. of Radiology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang (Korea, Republic of); Kim, Yook Kyung [Dept. of Radiology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul (Korea, Republic of); Kim, Yoon Kyung [Dept. of Radiology, Gachon University Gil Medical Center, Gachon University, Incheon (Korea, Republic of)

    2016-09-15

    Asbestosis is the most important change noted in the lung parenchyma after environmental and occupational exposure to asbestos fibers. It is characterized by diffuse interstitial pulmonary fibrosis. In Korea, the incidence of asbestosis will continue to increase for many years to come and the government enacted the Asbestos Damage Relief Law in 2011 to provide compensation to those suffering from asbestos-related diseases. Radiologic evaluation is necessary for diagnosis of asbestosis, and radiologists play a key role in this process. Therefore, it is important for radiologists to be aware of the various imaging features of asbestosis.

  3. Radiologic Diagnosis of Asbestosis in Korea

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    Cha, Yoon Ki; Kim, Jeung Sook [Department of Radiology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326 (Korea, Republic of); Kim, Yookyung [Department of Radiology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul 07985 (Korea, Republic of); Kim, Yoon Kyung [Department of Radiology, Gachon University Gil Medical Center, Gachon University, Incheon 21565 (Korea, Republic of)

    2016-11-01

    Asbestosis is the most important change noted in the lung parenchyma after environmental and occupational exposure to asbestos fibers. It is characterized by diffuse interstitial pulmonary fibrosis. In Korea, the incidence of asbestosis will continue to increase for many years to come and the government enacted the Asbestos Damage Relief Law in 2011 to provide compensation to those suffering from asbestos-related diseases. Radiologic evaluation is necessary for diagnosis of asbestosis, and radiologists play a key role in this process. Therefore, it is important for radiologists to be aware of the various imaging features of asbestosis.

  4. The problems of asbestosis in Spain.

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    Segarra, F

    1979-04-01

    About 50 cases of asbestosis have been descirbed in Spain from 1948 through 1974. Since 1975 the Instituto Territorial de Barcelona, Servicio Social de Higiene y Seguridad del Trabajo, has initiated a survey of all the industries with an asbestosis risk in the Barcelona area. Nearly 300 cases of asbestosis have been detected to date. Given the poor hygienic conditions of most of the industries, with an asbestosis risk, and the considerably large number of exposed people, it can easily be predicted that a rapid increase of the incidence of the disease in the years to come will occur. Most of the observed cases in Barcelona were from two fibrocement industries. Of a total of 1003 workers examined, 247 (about 25%) had asbestosis.

  5. Asbestosis

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    ... et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 73. Tarlo SM. Occupational lung disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil ...

  6. Asbestos and Asbestosis. LC Science Tracer Bullet.

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    Alderson, Karen L., Comp.

    Asbestos is a naturally occurring mineral found in several forms and because of its temperature-resisting properties, flexibility, and strength, it was widely used in the construction industry, automobile industry, and textile industry. Asbestos becomes dangerous when it crumbles and breaks releasing fibers that can cause asbestosis and certain…

  7. Iron and iron-related proteins in asbestosis.

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    ABSTRACT: We tested the postulate that iron homeostasis is altered among patients diagnosed to have asbestosis. Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferroportin 1 (FP...

  8. Retention of asbestos fibres in lungs of workers with asbestosis, asbestosis and lung cancer, and mesothelioma in Asbestos township.

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    Dufresne, A; Bégin, R; Massé, S; Dufresne, C M; Loosereewanich, P; Perrault, G

    1996-01-01

    OBJECTIVE: To conduct a mineralogical study on the particles retained in the necropsied lungs of a homogenous group of asbestos miners and millers from Asbestos township (and a local reference population) and to consider the hypothesis that there is a difference in size between fibres retained in the lungs of patients with asbestosis with and without lung cancer. METHODS: Samples of lung tissue were obtained from 38 patients with asbestosis without lung cancer, 25 with asbestosis and lung cancer, and 12 with mesothelioma, from necropsied Quebec chrysotile miners and millers from Asbestos township. Fibre concentrations in the lungs of these patients were compared with those in tissue from necropsies carried out on a local reference population: men who had died of either accidental death or acute myocardial infarction between 1990 and 1992. 23 were born before 1940 and 26 after 1940. RESULTS: Geometric mean (GM) concentrations were higher in cases than in the controls for chrysotile fibres 5 to 10 microns long in patients with asbestosis with or without lung cancer; for tremolite fibres 5 to 10 microns long in all patients; for crocidolite, talc, or anthophyllite fibres 5 to 10 microns long in patients with mesothelioma; for chrysotile and tremolite fibres > or = 10 microns long in patients with asbestosis; and crocidolite, talc, or anthophyllite fibres > or = 10 microns long in patients with mesothelioma. However, median concentrations of each type of fibre in the lungs did not show any significant differences between the three disease groups. Average length to diameter ratios of the fibres were calculated to be larger in patients with asbestosis and lung cancer than in those without lung cancer for crocidolite fibres > or = 10 microns long, for chrysotile, amosite, and tremolite fibres 5 to 10 microns long, and for chrysotile and crocidolite fibres Asbestos township who had an equal concentration of retained fibres but a tendency to a higher length to diameter

  9. Commentary on pathologic diagnosis of asbestosis and critique of the 2010 Asbestosis Committee of the College of American Pathologists (CAP) and Pulmonary Pathology Society's (PPS) update on the diagnostic criteria for pathologic asbestosis.

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    Hammar, Samuel P; Abraham, Jerrold L

    2015-10-01

    We reviewed the 2010 Asbestosis Committee's update on the diagnostic criteria for pathologic asbestosis. We must respectfully disagree with many of the criteria set forth therein, especially for recognizing asbestosis at its earliest stages; with statements focusing on the number of asbestos bodies needed in order to make a pathologic diagnosis of asbestosis; and regarding the benefits and pitfalls of relying on fiber analysis for diagnostic purposes, especially where chrysotile asbestos is concerned, including the methodology used for fiber determination. This critique has become even more relevant with the 2014 Helsinki criteria publication, which adopted the 2010 CAP/PPS criteria. Based on our review of these newer criteria and our experience in this field, we find that the CAP-NIOSH 1982 criteria is still the most acceptable method for the pathologic diagnosis and grading of asbestosis, which can be described as pulmonary fibrosis caused by inhalation of asbestos fibers.

  10. Interobserver variations in diagnosing asbestosis according to the ILO classification.

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    Perić, Irena; Novak, Katarina; Barisić, Igor; Mise, Kornelija; Vucković, Maja; Janković, Stipan; Tocilj, Jadranka

    2009-06-01

    Inhalation of asbestos fibres leads to asbestosis of the pleura and the lung, with possible progression to lung cancer and malignant pleural or peritoneal mesothelioma. Asbestosis remains difficult to diagnose, especially in its early stages. The most important role in its diagnosis is that of chest radiographs. The aim of this cross-sectional study was to address interobserver variations in interpreting chest radiographs in asbestos workers, which remain to be an issue, despite improvements in the International Labour Office (ILO) classification system. In our ten-year study, we investigated 318 workers occupationally exposed to asbestos, and in 210 workers with diagnosed asbestos-related changes we compared interpretations of chest radiographs according to ILO by two independent radiologists. The apparent degree of interobserver variation in classifying lung fibrosis was 26.66% for the diameter of changes and 42.2% for the profusion of the changes. In cases with diffuse pleural thickening, the interobserver variation using ILO procedures was 34.93%. This investigation raises the issue of standardisation and objectivity of interpretation of asbestosis according to the ILO classification system. This study has revealed a significant disagreement in the estimated degree of pleural and parenchymal asbestos pulmonary disease. This is why we believe high-resolution computed tomography (HRCT) should also be used as a part of international classification.

  11. Asbestosis: Past voices from the Mumbai factory floor

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    Abhijeet V Jadhav

    2012-01-01

    Full Text Available Background: Asbestos′s production, processing, and consumption is on very high scale in India and it is increasing, and so do the related diseases. Asbestosis is such a disease which causes progressive respiratory disability. Aim: To find out perceptions and thinking about this disease and its risk among the patients which will help in constructing an effective community-based prevention and rehabilitation program. Materials and Methods: It was a community-based, qualitative study using a semi-structured interview schedule with 17 asbestosis patients from Mumbai, disgnosed by specialist with pulmonary function test and X-rays as per International Labour Organisation′s recommandations. Results: The risk percived by the patients is very less and attitude toward the illness is bengine as there is no clear understanding about the causation. The prolong latent period appears to be the main cause. It suggests a need of very strong program for prevention of asbestosis with the incorporation of worker awareness and eduaction for safety. The socio-economical status and educational levels of the workers make this floating population more vulnarable for manipulation by the corporates. Conclusion: Apart from the radical step of ban on asbestos, there is a need of community-based sustainable, affordable, and accessible rehabilitation program with a component of palliative care which will consider the different needs of this marginalized group. The need for such a program is intense as the number of asbestisis patients will keep on increasing till 30 to 40 years of asbestos ban.

  12. Cancer Mortality and Asbestosis Among Workers in an Asbestos Plant in Chongqing, China

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    FEI ZHONG; EIJI YANO; ZHI-MING WANG; MIAN-ZHEN WANG; YA-JIA LAN

    2008-01-01

    Objective To investigate whether asbestosis is a risk factor for mortality of lung cancer. Methods A fixed cohort study was established in an asbestos plant in Chongqing, China, and followed up for 30 years from the beginning of 1972. Basic personal information on life state, cause of death, and diagnosis of asbestosis was collected. Multiple logistic regressions were applied to analyze risk factors. Results During the 30-year follow-up, 584 male workers constituting a total of 14 664 person-years were monitored and data were analyzed. Among them, 203 (34.8%) died and the mortality rate was 13.8 per 1000 person-years, cancer accounting for 37.4%. Excess risks were observed for lung cancer (OR=3.72) and nonmalignant respiratory diseases (OR=2.73) among workers with asbestosis. High-exposure level was another risk factor for lung cancer (OR=3.20). Workers with category Ⅱ of asbestusis demonsatrated a higher OR of both lung cancer and nonmalignant respiratory diseases than those with category Ⅰ of asbestosis. Conclusion High asbestos exposure level and asbestosis were the risk factors for death of lung cancer and nonmalignant respiratory diseases. Asbestosis is an independent risk factor for lung cancer among Chinese workers exposed to chrysotile, the risk increases with the increasing profusion of opacities of lung.

  13. Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations

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    Arakawa, Hiroaki [Dokkyo Medical University, Department of Radiology, Mibu, Tochigi (Japan); Kishimoto, Takumi [Okayama Rosai Hospital, Asbestos Research Center, Okayama (Japan); Ashizawa, Kazuto [Nagasaki University Graduate School of Biomedical Sciences, Department of Clinical Oncology, Nagasaki (Japan); Kato, Katsuya [Kawasaki Medical School, Department of Diagnostic Radiology 2, Okayama (Japan); Okamoto, Kenzo [Hokkaido Chuo Hospital, Department of Pathology, Iwamizawa, Hokkaido (Japan); Honma, Koichi [Dokkyo Medical University, Department of Pathology, Mibu, Tochigi (Japan); Hayashi, Seiji [National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka (Japan); Akira, Masanori [National Hospital Organization Kinki-Chuo Chest Medical Center, Department of Radiology, Osaka (Japan)

    2016-05-15

    The purpose was to identify distinguishing CT features of pathologically diagnosed asbestosis, and correlate diagnostic confidence with asbestos body burden. Thirty-three workers (mean age at CT: 73 years) with clinical diagnoses of asbestosis, who were autopsied (n = 30) or underwent lobectomy (n = 3), were collected. Two radiologists independently scored high-resolution CT images for various CT findings and the likelihood of asbestosis was scored. Two pathologists reviewed the pathology specimens and scored the confidence of their diagnoses. Asbestos body count was correlated with CT and pathology scores. Pathologically, 15 cases were diagnosed as asbestosis and 18 cases with various lung fibroses other than asbestosis. On CT, only the score of the subpleural curvilinear lines was significantly higher in asbestosis (p = 0.03). Accuracy of CT diagnosis of asbestosis with a high confidence ranged from 0.73 to 0.79. Asbestos body count positively correlated with CT likelihood of asbestosis (r = 0.503, p = 0.003), and with the confidence level of pathological diagnosis (r = 0.637, p < 0.001). Subpleural curvilinear lines were the only clue for the diagnosis of asbestosis. However, this was complicated by other lung fibrosis, especially at low asbestos body burden. (orig.)

  14. Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis

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    Sangani RG

    2015-05-01

    Full Text Available Rahul G Sangani,1 Andrew J Ghio,2 John E Parker11Department of Pulmonary and Critical Care Medicine, West Virginia University, Morgantown, WV, USA; 2Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC, USABledsoe et al presents an interesting study examining the disparities between radiologic and pathologic diagnoses of asbestosis in cases referred for consultation in pulmonary malignancy.1 The authors conclude that the clinical diagnosis of asbestosis cannot be reliably distinguished from interstitial fibrosis in heavy smokers. These findings highlight the confounding role of cigarette smoking in the diagnosis of asbestosis when it is based on non-pathologic criteria.View original paper by Bledsoe et al.

  15. Asbestosis in an asbestos composite mill at Mumbai: A prevalence study

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    Kanhere Vijay

    2005-10-01

    Full Text Available Abstract Background Of an estimated 100000 workers exposed to asbestos in India, less than 30 have been compensated. The reasons for such a small number are: refusal by management sponsored studies to grant medical certifications to workers suffering from occupational diseases, lack of training for doctors in diagnosis of occupational lung diseases, deliberate misdiagnosis by doctors of asbestosis as either chronic bronchitis or tuberculosis and the inherent class bias of middle class doctors against workers. The aim of the study was to identify workers suffering from Asbestosis (parenchymal and pleural non-malignant disease among the permanent workers of the Hindustan Composites Factory and assess their disability and medically certify them, whereupon they could avail of their basic rights to obtain compensation and proper treatment. Methods The study was conducted by the Occupational Health and Safety Centre and the Workers' Union. Asbestosis was diagnosed if they had an occupational history of asbestos exposure for at least 15 years and showed typical radiographic findings. Results Of 232 workers in the factory, 181 participated in the survey. 22% of them had asbestosis. All the asbestos affected workers had at least 20 years of exposure. 7% had rhonchi, 34% had late basal inspiratory rates, 82% had more than 80% of Forced Expiratory Volume in the first second (FEV1/Forced Vital capacity (FVC ratio and 66% had FVC less than 80% of the predicted value. On radiology 7% had only pleural disease, 10% had both pleural and parenchymal disease and 82% had only parenchymal disease. The association of pleural disease with chest pain was statistically significant. Conclusion We found the prevalence of asbestosis among exposed workers to be less than that anticipated for the number of years of exposure due to "Healthy Worker Effect". We suggest that all affected asbestos workers (including those who have been forced to leave in India be medically

  16. Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis

    Institute of Scientific and Technical Information of China (English)

    Motoko Sasaki; Ichiro Araki; Toshiaki Yasui; Masaru Kinoshita; Keita Itatsu; Takayuki Nojima; Yasuni Nakanuma

    2009-01-01

    We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-yearold man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6,mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15,BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type.

  17. Fatal asbestosis 50 years after brief high intensity exposure in a vermiculite expansion plant.

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    Wright, Robert S; Abraham, Jerrold L; Harber, Philip; Burnett, Bryan R; Morris, Peter; West, Phil

    2002-04-15

    The authors report the case of a 65-year-old accountant whose only asbestos exposure was during a summer job 50 years earlier in a California vermiculite expansion plant. Vermiculite is a silicate material that is useful in building and agriculture as a filler and insulating agent. He developed extensive fibrocalcific pleural plaques and end-stage pulmonary fibrosis, with rapidly progressive respiratory failure. Careful occupational and environmental history revealed no other source of asbestos exposure, and the initial clinical diagnosis was idiopathic pulmonary fibrosis; open lung biopsy shortly before his death confirmed asbestosis. Electron microscopic lung fiber burden analysis revealed over 8,000,000 asbestos fibers per gram dry lung, 68% of which were tremolite asbestos. Additional asbestiform fibers of composition not matching any of the standard asbestos varieties were also present at over 5,000,000 fibers per gram dry lung. Comparison analysis of a sample of Libby, Montana, vermiculite showed a similar mix of asbestiform fibers including tremolite asbestos. This case analysis raises several concerns: risks of vermiculite induced disease among former workers of the more than 200 expansion plants throughout the United States; health effects of brief but very high-intensity exposures to asbestos; and possible health effects in end-users of consumer products containing vermiculite.

  18. Autopsia por silico-asbestosis: revisión a propósito de un caso forense

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    A. Sibón Olano

    2014-09-01

    Full Text Available Se presenta el caso de un varón de 72 años de edad, ex fumador desde hace años, diagnosticado de silicosis y carcinoma epidermoide de pulmón derecho, solicitándose por parte de la familia autopsia judicial por la sospecha de padecimiento de asbestosis y tras su confirmación reclamación como enfermedad profesional. La exposición de este suceso nos permite realizar una revisión de una enfermedad profesional que suele pasar como desconocida en las salas de autopsia, a pesar de su repercusión judicial. La asbestosis es un tipo de neumoconiosis reconocida como enfermedad profesional producida por la inhalación de fibras de asbesto. Su inhalación provoca fibrosis pulmonar. Presenta un tiempo de latencia clínica inversamente proporcional al nivel de exposición. Además de fibrosis pulmonar pueden producirse derrames pleurales, placas fibrosas pleurales, mesoteliomas, carcinomas pleurales y carcinoma de laringe. La silicosis es la neumoconiosis producida por inhalación de partículas de sílice, entendiendo por neumoconiosis la enfermedad ocasionada por el depósito de polvo en los pulmones con una reacción patológica frente a este, en especial de tipo fibroso. La silicosis es una enfermedad fibrótica-pulmonar de carácter irreversible y considerada enfermedad profesional incapacitante en muchos países, una de cuyas variantes más raras es la silico-asbestosis, la cual requiere exposición al sílice y al amianto.

  19. Autopsia por silico-asbestosis: revisión a propósito de un caso forense

    OpenAIRE

    A. Sibón Olano; E. Sánchez Rodríguez; E. Barrera Pérez; J. Larrondo Espinosa; M. Salguero Villadiego

    2014-01-01

    Se presenta el caso de un varón de 72 años de edad, ex fumador desde hace años, diagnosticado de silicosis y carcinoma epidermoide de pulmón derecho, solicitándose por parte de la familia autopsia judicial por la sospecha de padecimiento de asbestosis y tras su confirmación reclamación como enfermedad profesional. La exposición de este suceso nos permite realizar una revisión de una enfermedad profesional que suele pasar como desconocida en las salas de autopsia, a pesar de su repercusión jud...

  20. [Comparison of descriptive expressions between ILO U/C international classification of radiographs of pneumoconiosis 1971 and Japanese classification of pneumoconiosis law in Japan 1960 in pulmonary asbestosis (author's transl)].

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    Horai, Z

    1977-07-01

    In the explanatory text of the ILO U/C International classification of Radiographs of Pneumoconiosis (1971) sent to Japan in 1973, items of its expression on pulmonary asbestosis were analyzed by the author. On the other hand, items of Japanese Asbestosis Classification of Pneumoconiosis Law were also analyzed. The ILO U/C International Classification of Radiographs of Pneumoconiosis (1971) have some confused words. As to pulmonary asbestosis, an expression of irregular opacities is used, but the fundamental X-ray opacities such as linear opacities are forgot in the description. The X-ray findings of the pulmonary asbestosis are divided into 3 types as s, t and u. It is, however, difficult in practice to divide X-ray findings of the pulmonary asbestosis into such types. The classification of X-ray findings of the pulmonary asbestosis in the Japanese Pneumoconiosis Law is based on the classification worked out by many investigators i; the past, providing for simplicity and ease of handling.

  1. Differentiation of the ILO boundary chest roentgenograph (0/1 to 1/0) in asbestosis by high-resolution computed tomography scan, alveolitis, and respiratory impairment.

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    Harkin, T J; McGuinness, G; Goldring, R; Cohen, H; Parker, J E; Crane, M; Naidich, D P; Rom, W N

    1996-01-01

    High-resolution computed tomography (HRCT) scans have been advocated as providing greater sensitivity in detecting parenchymal opacities in asbestos-exposed individuals, especially in the presence of pleural fibrosis, and having excellent inter- and intraobserver reader interpretation. We compared the 1980 International Labor Organization (ILO) International Classification of the Radiographs of the Pneumoconioses for asbestosis with the high-resolution CT scan using a grid scoring system to better differentiate normal versus abnormal in the ILO boundary 0/1 to 1/0 chest roentgenograph. We studied 37 asbestos-exposed individuals using the ILO classification, HRCT grid scores, respiratory symptom questionnaires, pulmonary function tests, and bronchoalveolar lavage. We used Pearson correlation coefficients to evaluate the linear relationship between outcome variables and each roentgenographic method. The normal HRCT scan proved to be an excellent predictor of "normality," with pulmonary function values close to 100% for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), total lung capacity (TLC), and carbon monoxide diffusing capacity (DLCO) and no increase in BAL inflammatory cells. Concordant HRCT/ILO abnormalities were associated with reduced FEV1/FVC ratio, reduced diffusing capacity, and alveolitis consistent with a definition of asbestosis. In our study, the ILO classification and HRCT grid scores were both excellent modalities for the assessment of asbestosis and its association with impaired physiology and alveolitis, with their combined use providing statistical associations with alveolitis and reduced diffusing capacity.

  2. Incidencia en España de la asbestosis y otras enfermedades pulmonares benignas debidas al amianto durante el período 1962-2010

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    Montserrat García Gómez

    2012-01-01

    Full Text Available Fundamentos: En España carecemos de una descripción completa de las enfermedades profesionales causadas por el amianto. El objetivo del presente trabajo esconocer la incidencia durante el período 1962-2010 de las asbestosis y otras enfermedades pulmonares benignas por amianto reconocidas como profesionales y su distribución por sectores, ocupación, sexo y ámbito geográfico. Métodos: El número de casos se obtuvo de las Memorias del INP (años 1962 a 1975, de la Estadística del Ministerio de Trabajo y las Memorias del Servicio de Higiene y Seguridad en el Trabajo (1976 a 1981 y de los Anuarios de Estadísticas Laborales a partir de 1982. Se obtuvieron tasas de incidencia específicas por actividad económica y ocupación. Se estudió la tendencia temporal del número de enfermedades a estudio, así como su distribución geográfica por Comunidad Autónoma y provincia. Resultados: Desde 1963 hasta 2010 se reconocieron 815 asbestosis y 46 afecciones fibrosantes de pleura y pericardio. La incidencia media anual de asbestosis fue 0,20 por 100.000 personas asalariadas (0,31 en el año 1990 y 0,40 en 2010. De 1990 a 2001 el sector del fibrocemento acumuló 189 casos de asbestosis, el naval 173, la construcción 49 y la metalurgia 35. Por ocupación, los operadores de maquinas fijas presentaron 114 casos, los moldeadores, soldadores, chapistas y montadores de estructuras metálicas 88 casos y los pintores, fontaneros e instaladores de tuberías 59. Las Comunidades Autónomas con más casos fueron la Valenciana (106, Galicia (86, Andalucía (82, Cataluña (75, Madrid (58 y País Vasco (41. Conclusiones: Las tasas de incidencia y la tendencia de asbestosis profesionales en España pueden estar evidenciando el infrareconocimiento del origen profesional de estas enfermedades en nuestro país. Los sectores más afectados fueron el del fibrocemento y el naval y la incidencia más alta se dió en la Comunidad Valenciana.

  3. Study on the dose-response relationship of asbestosis prevalence%接触石棉尘量与石棉肺发病的剂量-反应关系研究

    Institute of Scientific and Technical Information of China (English)

    孙统达; 朱胜军

    2001-01-01

    Objective To learn the dose-response relationship of asbestosis prevalence in the workers of small towns chrysotile processing plants.Methods To collect the chrysotile dust concentration records of all workplaces and the prevalence of asbestosis during recent 37 years;the chrysotile fiber concentration could be gotten by calculation from the chrysotile dust concentration;the amount of accumulative exposure amount to chrysotile fibers might be calculated from exposure concentration multiplied with exposure time.The dose-response relationship between chrysotile and fiber concentration and? asbestosis prevalence was established by the method of life table.Results The maximum allowable dust concentration and fiber concentration of asbestos dust were predicted as 2.71mg/m3 and 1.93 f/ml respectively,according to the presumption that the workers would work for 30 years and the prevalence of asbestosis would be controlled under 1%.Conclusion The present hygienic standard of asbestos dust(MAC)of our country is reasonable.%目的探讨乡镇石棉加工人员接触石棉尘量与石棉肺发病的剂量-反应关系。方法记录接尘工人的职业史、体检史,纤维计数浓度由质量浓度通过公式换算得到,累积接尘量由接触浓度与时间相乘所得,以寿命表法建立石棉尘质量浓度与纤维计数浓度的剂量患病概率直线回归方程式。结果按1%石棉肺患病率、工人30年工作年限计算,预测石棉尘质量浓度与纤维计数浓度应低于2.71mg/m3与1.93f/ml。结论现行国家石棉尘卫生标准是合理的。

  4. Asbesto, asbestose e câncer: critérios diagnósticos Asbestos, asbestosis and cancer: diagnostic criteria

    Directory of Open Access Journals (Sweden)

    VERA LUIZA CAPELOZZI

    2001-07-01

    Full Text Available As doenças asbesto-induzidas constituem um grave problema de saúde em decorrência de grande número de trabalhadores expostos ao asbesto ao longo dos últimos 50 anos. Processos judiciais contra indústrias que lidam com asbesto somam centenas, com crescente adição de novos casos. O assunto relativo à asbestose é complexo e, muito embora a história natural das doenças induzidas esteja bem estabelecida, muitas áreas importantes, como a patologia, permanecem ainda pouco compreendidas. No Brasil, desde 1940, o asbesto é explorado comercialmente e nos últimos anos sua produção foi da ordem de 200.000 toneladas por ano, estimando-se que na atividade de mineração cerca de 10.000 trabalhadores foram expostos a essa fibra, desconhecendo-se a estimativa do número de pessoas expostas na produção de fibrocimento, especialmente telhas e caixas d'água. Um estudo, com metodologia de investigação científica apropriada, para avaliar as repercussões sobre a saúde dos trabalhadores nas minas de asbesto em nosso país, foi elaborado e intitulado "Morbidade e mortalidade entre trabalhadores expostos ao asbesto na atividade de mineração 1940-1996", de cunho interinstitucional. O objetivo deste trabalho foi fornecer uma visão ampla das doenças asbesto-induzidas, com ênfase nas dificuldades no diagnóstico histopatológico, através da experiência adquirida com o desenrolar desse projeto.Asbestos-induced diseases are still major health problems, as a remarkably large number of workers have been exposed to asbestos over the past 50 years. Personal injury lawsuits against asbestos manufacturers number hundreds of thousands, and new cases are still being filed. Asbestosis is a complex issue, and although the broad outlines of asbestos-related diseases are well set, many important areas, especially pathology, are poorly understood. In Brazil, since 1940, asbestos has been commercially explored, producing around 200,000 tons/year, exposing

  5. Inherited glutathione-S-transferase deficiency is a risk factor for pulmonary asbestosis.

    Science.gov (United States)

    Smith, C M; Kelsey, K T; Wiencke, J K; Leyden, K; Levin, S; Christiani, D C

    1994-09-01

    Pulmonary diseases attributable to asbestos exposure constitute a significant public health burden, yet few studies have investigated potential genetic determinants of susceptibility to asbestos-related diseases. The glutathione-S-transferases are a family of conjugating enzymes that both catalyze the detoxification of a variety of potentially cytotoxic electrophilic agents and act in the generation of sulfadipeptide leukotriene inflammatory mediators. The gene encoding glutathione-S-transferase class mu (GSTM-1) is polymorphic; approximately 50% of Caucasian individuals have a homozygous deletion of this gene and do not produce functional enzyme. Glutathione-S-transferase mu (GST-mu) deficiency has been previously reported to be associated with smoking-induced lung cancer. We conducted a cross-sectional study to examine the prevalence of the homozygous deletion for the GSTM-1 gene in members of the carpentry trade occupationally exposed to asbestos. Members of the United Brotherhood of Carpenters and Joiners of America attending their 1991 National Union conference were invited to participate. Each participant was offered a chest X-ray and was asked to complete a comprehensive questionnaire and have their blood drawn. All radiographs were assessed for the presence of pneumoconiosis in a blinded fashion by a National Institute for Occupational Safety and Health-certified International Labor Office "B" reader. Individual GSTM-1 status was determined using polymerase chain reaction methods. Six hundred fifty-eight workers were studied. Of these, 80 (12.2%) had X-ray abnormalities associated with asbestos exposure. Individuals genetically deficient in GST-mu were significantly more likely to have radiographic evidence of nonmalignant asbestos-related disease than those who were not deficient (chi 2 = 5.0; P < 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)

  6. [Genetic polymorphism of haptoglobin and quantitative changes in its levels during exposure to asbestos].

    Science.gov (United States)

    Afanas'eva, I S; Spitsyn, V A; Tsurikova, G V

    1993-11-01

    The polymorphism and serum levels of haptoglobin were studied in asbestosis patients, in the control and the workers exposed to asbest. Hp1-1 has the highest, Hp2-2--the lowest and Hp2-1 has the intermediate concentration of this protein. In the course of contact with asbest, and especially in asbestosis patients, the haptoglobin levels are higher (for all phenotypes). The standard deviation from the Hp concentration in asbestosis patients was significantly higher. The phenotypes Hp1-1 were found more often in asbestosis patients than among asbest-exposed workers.

  7. The importance of lung function, non-malignant diseases associated with asbestos, and symptoms as predictors of ischaemic heart disease in shipyard workers exposed to asbestos.

    Science.gov (United States)

    Sandén, A; Järvholm, B; Larsson, S

    1993-01-01

    The mortality from ischaemic heart disease was studied in a prospective cohort of 1725 shipyard workers exposed to asbestos. The analyses were stratified for age and smoking habits and restricted to men. In agreement with other findings, men with impaired lung function had a significantly higher risk (relative risk (RR) = 3.5) of dying from ischaemic heart disease than men with normal lung function. Men with asbestosis or suspected asbestosis had a significantly higher risk (RR = 3.1) of dying from ischaemic heart disease than men without asbestosis. Thus asbestosis or suspected asbestosis also seemed to be a risk factor for ischaemic heart disease. This finding was independent of respiratory function. There was no increased risk for ischaemic heart disease in men with compared with men without pleural plaques. Men with production of phlegm or sputum and wheezing or whistling had no increased risk for ischaemic heart disease compared with men without these symptoms. In the group with normal lung function men with dyspnoea had a significantly higher risk of dying from ischaemic heart disease than men without dyspnoea. The findings for men with asbestosis or suspected asbestosis indicated a further risk factor besides impaired lung function, in persons exposed to asbestos. Perhaps this risk factor is due to lesions of the pericardium with consequences for heart function. PMID:8398871

  8. 77 FR 20434 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Standard on...

    Science.gov (United States)

    2012-04-04

    ... (DOL) will submit the Occupational Safety and Health Administration (OSHA) sponsored information... to asbestos can cause numerous disabling or fatal diseases, including asbestosis, a disease in which lung scarring (fibrosis) impairs breathing and causes death from respiratory or heart failure;...

  9. [WHO and ILO Program on elimination of asbestos-related diseases].

    Science.gov (United States)

    Izmerov, N F

    2008-01-01

    The article covers analysis of contemporary international documents on asbestosis problem. Suggestions are presented to Russia participation in realization of joint WHO and ILO Program on elimination of asbestos-related diseases.

  10. Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

    Science.gov (United States)

    2016-04-19

    Lung Transplant; Lung Resection; Lung Cancer; Asthma; Cystic Fibrosis; Chronic Obstructive Pulmonary Disease; Emphysema; Mesothelioma; Asbestosis; Pulmonary Embolism; Interstitial Lung Disease; Pulmonary Fibrosis; Bronchiectasis; Seasonal Allergies; Cold Virus; Lung Infection; Pulmonary Hypertension; Pulmonary Dysplasia; Obstructive Sleep Apnea

  11. Environmental Assessment East Coast Basing of C-17 Aircraft. Volume 1

    Science.gov (United States)

    2005-09-01

    with exposure to airborne asbestos fibers include asbestosis, lung cancer , and mesothelioma. Although the USEPA promulgated a ban on asbestos and...include: broomsedge, little bluestem, barnyard grass, several species of foxtail, Canada thistle, milkweed , early goldenrod, and common reed

  12. [Ecogenetic aspects of the study of phenotypes and levels of beta-aminoisobutyric acid excretion].

    Science.gov (United States)

    Spitsyn, V A; Afanas'eva, I S; Alekseeva, N V

    1993-11-01

    The levels of excretion of beta-aminoisobutyric acid (BAIB) in urea were examined in five groups. The distribution of BAIB concentration revealed the existence of high and low excretors in each group. Asbestosis patients had the lowest frequency of high excretors. The BAIB concentration among high excretors was similar for all the groups. The BAIB levels of low excretors varied. The most alike were two children groups, asbestosis patients and the workers from the town Asbest.

  13. Association Between Polymorphisms of DNA Repair Gene XRCC1 and DNA Damage in Asbestos-Exposed Workers

    Institute of Scientific and Technical Information of China (English)

    XIAO-HONG ZHAO; GUANG JIA; YONG-QUAN LIU; SHAO-WEI LIU; LEI YAN; YU JIN; NIAN LIU

    2006-01-01

    Objective To compare the asbestos-induced DNA damage and repair capacities of DNA damage between 104 asbestos exposed workers and 101 control workers in Qingdao City of China and to investigate the possible association between polymorphisms in codon 399 of XRCC1 and susceptibility to asbestosis. Methods DNA damage levels in peripheral bloodlymphocytes were determined by comet assay, and XRCC 1 genetic polymorphisms of DNA samples from 51 asbestosis cases and 53 non-asbestosis workers with a similar asbestos exposure history were analyzed by PCR/RFLP. Results The basal comet scores (3.95±2.95) were significantly higher in asbestos-exposed workers than in control workers (0.10±0.28). After 1 h H2O2 stimulation, DNA damage of lymphocytes exhibited different increases. After a 4 h repair period, the comet scores were 50.98±19.53 in asbestos-exposed workers and 18.32±12.04 in controls. The residual DNA damage (RD) was significantly greater (P<0.01) in asbestos-exposed workers (35.62%) than in controls (27.75%). XRCC1 genetic polymorphism in 104 asbestos-exposed workers was not associated with increased risk of asbestosis. But compared with polymorphisms in the DNA repair gene XRCC1 (polymorphisms in codon 399) and the DNA damage induced by asbestos, the comet scores in asbestosis cases with Gln/Gln, Gln/Arg, and Arg/Arg were 40.26±18.94, 38.03±28.22, and 32.01±11.65, respectively, which were higher than those in non-asbestosis workers with the same genotypes (25.58±11.08, 37.08±14.74, and 29.38±10.15). There were significant differences in the comet scores between asbestosis cases and non-asbestosis workers with Gln/Gln by Student's t-test (P<0.05 or 0.01). The comet scores were higher in asbestosis workers with Gln/Gln than in those with Arg/Arg and in non-asbestosis workers exposed to asbestos, but without statistically significant difference. Conclusions Exposure to asbestos may be related to DNA damage or the capacity of cells to repair H2O2-induced

  14. Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos.

    Science.gov (United States)

    Stayner, L; Smith, R; Bailer, J; Gilbert, S; Steenland, K; Dement, J; Brown, D; Lemen, R

    1997-01-01

    OBJECTIVES: To evaluate alternative models and estimate risk of mortality from lung cancer and asbestosis after occupational exposure to chrysotile asbestos. METHODS: Data were used from a recent update of a cohort mortality study of workers in a South Carolina textile factory. Alternative exposure-response models were evaluated with Poisson regression. A model designed to evaluate evidence of a threshold response was also fitted. Lifetime risks of lung cancer and asbestosis were estimated with an actuarial approach that accounts for competing causes of death. RESULTS: A highly significant exposure-response relation was found for both lung cancer and asbestosis. The exposure-response relation for lung cancer seemed to be linear on a multiplicative scale, which is consistent with previous analyses of lung cancer and exposure to asbestos. In contrast, the exposure-response relation for asbestosis seemed to be nonlinear on a multiplicative scale in this analysis. There was no significant evidence for a threshold in models of either the lung cancer or asbestosis. The excess lifetime risk for white men exposed for 45 years at the recently revised OSHA standard of 0.1 fibre/ml was predicted to be about 5/1000 for lung cancer, and 2/1000 for asbestosis. CONCLUSIONS: This study confirms the findings from previous investigations of a strong exposure-response relation between exposure to chrysotile asbestos and mortality from lung cancer, and asbestosis. The risk estimates for lung cancer derived from this analysis are higher than those derived from other populations exposed to chrysotile asbestos. Possible reasons for this discrepancy are discussed. PMID:9423577

  15. Health hazards from fine asbestos dusts. An analysis of 70,656 occupational preventive medical investigations from 1973 to the end of 1986.

    Science.gov (United States)

    Raithel, H J; Weltle, D; Bohlig, H; Valentin, H

    1989-01-01

    For the period from 1973 to the end of 1986, 70,656 data sets on occupational preventive medical examinations in employees exposed occupationally to asbestos dust (G 1.2) were made available to us by the Central Registry for Employees Exposed to Asbestos Dust (ZAS). On the basis of this data, an analysis of asbestosis risk was to be made in relation to specific areas of work, taking into consideration the beginning and duration of exposure. Proceedings for declaratory appraisal in accordance with occupational disease no. 4103 were instituted in 1760 cases in the report period. In accordance with the character of the available data, the X-ray findings in the lungs were available from the persons investigated as parameters of possible asbestosis risk on the basis of coding consistent with the International Pneumoconiosis Classification (ILO U/C 1971 and/or ILO 1980 West Germany). The major result of the statistical analyses on the mainframe macrocomputer of the University of Erlangen-Nuremberg was that the relatively highest risk of asbestosis was present in persons whose exposure began before 1955. On the other hand, with increasing duration of exposure, an unequivocal rise of the asbestosis risk could not be detected on the basis of the overall population. In relation to the individual fields of work, the relatively highest risk of asbestosis was shown to be in the asbestos textile and paper industry, as well as in the asbestos cement industry. No detectable risk of asbestosis was present in the fields of mining, traffic and health service and for women in the industrial sectors of building material, gas and water, catering trade, building, commerce as well as banking and insurance. Accordingly, it can be assumed that certain fields of work are or were exposed to such a small extent or not at all that a risk of asbestosis which is relevant in terms of occupational medicine is no longer to be assumed or was not to be assumed. This applies above all to certain work

  16. Oversight Hearings on Asbestos Health Hazards to Schoolchildren. Hearings before the Subcommittee on Elementary, Secondary, and Vocational Education of the Committee on Education and Labor. House of Representatives, Ninety-Sixth Congress, First Session on H.R. 1435 and H.R. 1524 (January 8, 16, and February 22, 1979).

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    Testimony and prepared statements presented during three days of hearings in January and February, 1979, concern the problems of asbestos in school buildings. Medical research indicates that the inhalation of asbestos dust vastly increases a person's chances of contacting fatal diseases such as lung cancer, mesothelioma, and asbestosis. Asbestos…

  17. 75 FR 17164 - Asbestos in General Industry; Extension of the Office of Management and Budget's (OMB) Approval...

    Science.gov (United States)

    2010-04-05

    ... Occupational Safety and Health Administration Asbestos in General Industry; Extension of the Office of... requirements specified in its Standard on Asbestos in General Industry (29 CFR 1910.1001). DATES: Comments must... workers with protection from hazardous asbestos exposure. Asbestos exposure results in asbestosis,...

  18. SUBCHRONIC INHALATION EXPOSURE OF RATS TO LIBBY AMPHIBOLE AND AMOSITE ASBESTOS

    Science.gov (United States)

    Exposure to Libby amphibole (LA) is associated with significant increases in asbestosis, lung cancer, and mesothelioma. To support biological potency assessment and dosimetry model development, a subchronic nose-only inhalation exposure study (6 hr/d, 5 d/wk, 13 wk) was conducted...

  19. March 2014 ciritcal care case of the month: interstitial lung disease

    Directory of Open Access Journals (Sweden)

    Yun S

    2014-03-01

    Full Text Available No abstract available. Article truncated after 150 words. History of Present Illness An 80 year-old man with a history of chronic obstructive pulmonary disease, asbestosis and interstitial lung disease, presented to the outpatient clinic with cough, sinus congestion and mild sputum. He was sent home with amoxicillin for the treatment of a sinus infection. However, he came back to emergency department with worsening respiratory symptoms including shortness of breath and persistent cough. He required 8-10 L/min of oxygen to maintain an oxygen saturation above 90 %. PMH: COPD, Asbestosis, Interstitial lung disease, Diabetes mellitus type II, Hypertension, Aortic valve replacement. Medications: Fluticasone-salmeterol 250-50 mcg inhaler, Mometasone 50 mcg/actuation nasal spray, Furosemide 40 mg PO daily, Felodipine 5 mg PO BID, Warfarin 3 mg PO daily, Insulin aspart 5 units SC injection before meals, Insulin glargine 15 units SC injection night time. Social History 50 pack-year ...

  20. Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos.

    Science.gov (United States)

    Pesch, Beate; Taeger, Dirk; Johnen, Georg; Gross, Isabelle M; Weber, Daniel G; Gube, Monika; Müller-Lux, Alice; Heinze, Evelyn; Wiethege, Thorsten; Neumann, Volker; Tannapfel, Andrea; Raithel, Hans-Jürgen; Brüning, Thomas; Kraus, Thomas

    2010-01-01

    The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were calculated and Poisson regression was performed to assess mesothelioma risks. A high risk was observed for pleural mesothelioma (SMR 28.10, 95% CI 15.73-46.36) that decreased after cessation of exposure (RR 0.1; 95% CI 0.0-0.6 for > or =30 vs. <30 years after last exposure). Asbestosis was a significant risk factor for mesothelioma (RR 6.0, 95% CI 2.4-14.7). Mesothelioma mortality was still in excess in former asbestos workers although decreasing after cessation of exposure. Fibrosis was associated with subsequent malignancy.

  1. Mining and mendacity, or how to keep a toxic product in the marketplace.

    Science.gov (United States)

    McCulloch, Jock

    2005-01-01

    The corruption of medical evidence about the hazards of asbestos began with the Canadian mines. Quebec at one time boasted ten of the 13 mines in Canada. Work conditions in the mines were harsh, and the mills were full of airborne fiber. Given the size of the industry, the Quebec mines were where occupational asbestosis should first have been identified, but research at the mines was done in company towns, where clinics were staffed by company doctors. Since the late 1920s U.S. parent companies and their Canadian subsidiaries have maintained that there is little if any disease among mine workers. Asbestosis in textile workers, they have claimed, has been due to the conditions in that industry and not the inherent dangers of asbestos. That fiction continues to shape the discourse about the usefulness of asbestos.

  2. Historical developments and perspectives in inorganic fiber toxicity in man.

    OpenAIRE

    Selikoff, I J

    1990-01-01

    The first patient known to have died from asbestosis (1900) began work in 1885, approximately 5 years after the industrial use of asbestos began in Britain. Mineral particles were found in his lungs. No special comment was made of their fibrous nature then nor when the first case was reported in 1924. The various neoplasms attributed to asbestos in the next decades posed an additional question: What influence did the fibrous shape of the particles have on carcinogenic potential? The cogency o...

  3. Relation of airway responsiveness to duration of work in a dusty environment.

    OpenAIRE

    Ernst, P.; Dales, R E; Nunes, F.; Becklake, M. R.

    1989-01-01

    Health selection within a workforce has been found in several industries and appears to be more pronounced in dustier occupations. In this study of airway disease among workers exposed to asbestos and man made mineral fibres, 215 of 246 construction insulators 50 years old or less and currently working in the Montreal area were examined. Spirometry was completed successfully in 214 workers without known asbestosis and 207 underwent methacholine bronchoprovocation testing. Airway responsivenes...

  4. Pitfalls in diagnostic imaging and assessment of benign asbestos-related thoracic diseases; Fallstricke in der radiologischen Diagnostik und Begutachtung der benignen asbestbedingten Erkrankungen des Thorax

    Energy Technology Data Exchange (ETDEWEB)

    Rehbock, B. [Praxis fuer Diagnostische Radiologie am St.-Hedwig-Krankenhaus Berlin-Mitte, Berlin (Germany). Diagnostische Radiologie; Hofmann-Preiss, K. [Radiologische Gemeinschaftspraxis Erlangen (Germany). Radiologische Diagnostik; Kraus, T. [Universitaetsklinikum der RWTH Aachen (Germany). Inst. fuer Arbeits- und Sozialmedizin

    2012-05-15

    The recognition of asbestos-related diseases of the lung and/or pleura as an occupational disease is of psychosocial, medical and legal importance to the insured person. Radiological imaging is an essential part of the assessment and requires an increasingly high level of competence in the field of radiological diagnosis of pneumoconiosis in interdisciplinary collaboration with occupational medicine and pneumonology. The chest radiogram remains an integral part of basic diagnostic procedures in asbestos-related diseases of the lungs and/or pleura. Its importance lies in the detection of extended pleural changes as well as substantial fibrosis. The inherent low sensitivity and specificity of projection radiography is taken into account by the increasing use of multi-slice high resolution (HR) CT (in low dose technique). Radiological pitfalls in pleural plaque assessment with respect to plain chest X-ray concern all structures that superimpose on the pleural circumference, particularly the anatomical layers of the chest wall (extra-pleural fatty tissue, muscles, thoracic skeleton) as well as other pulmonary findings that can only be reliably assigned using CT. Even if state-of the-art CT is applied, asymmetries and abnormal expression of anatomical structures and variants (e.g. muscles and blood vessels) can lead to false-positive findings. The interstitial fibrosis of asbestosis, manifested as usual interstitial pneumonia (UIP) is non-pathognomonic for asbestosis. Therefore, parietal pleural thickening as a coincident finding to UIP is considered as being the main feature and a highly suggestive indicator of asbestosis in patients with a history of asbestos exposure. (orig.)

  5. Patterns of pulmonary dysfunction in asbestos workers: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Kales Stefanos N

    2010-06-01

    Full Text Available Abstract Background Restrictive patterns of pulmonary function abnormalities associated with asbestos exposure are well described. Studies are less consistent, however, regarding the association of asbestos inhalation with airway dysfunction and obstructive impairment. Methods We compared pulmonary function test results between 277 chrysotile exposed workers (22% non-smokers and 177 unexposed controls (50.3% non-smokers. Information on exposure and smoking were collected using a standardized questionnaire. Standardized spirometric and DCLO Measurement methods were utilized. CXRs were read based on ILO pneumoconiosis guidelines. Results Asbestos exposed subjects had significantly reduced FVC, FEV1, FEV1/FVC and DLCO. Restricting the analysis to non-smokers, asbestos workers still had about 3% lower FEV1/FVC ratio than controls, but this difference did not reach statistical significance. Among exposed workers, the presence of radiographic evidence of asbestosis further lowered FVC and DLCO but not FEV1/FVC compared to asbestos exposure without radiographic asbestosis. Additionally, smoking asbestos workers had significantly lower DLCO compared to non-smoking workers. Conclusion Asbestos exposure, especially when radiographic evidence of interstitial fibrosis from asbestosis is present, leads to significant decreases in FVC, FEV1 and the DLCO. However, asbestos exposure alone is not significantly associated with a reduction of the FEV1/FVC. Smoking-asbestos workers had significantly lower DLCO than their non-smoking counterparts. Whether asbestos interacts with smoking additively or synergistically on DLCO needs further investigation. Similarly, further studies are needed to assess the progression and clinical significance of asbestos induced airway dysfunction.

  6. Proposed national strategies for the prevention of leading work-related diseases and injuries. Part 1

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    Preliminary strategies developed at the National Symposium on the Prevention of Leading Work Related Diseases and Injuries, held in Atlanta, Georgia on May 1 to 3, 1985 were revised, elaborated, and further developed. Strategies were developed for the prevention of occupational lung diseases, musculoskeletal injuries, occupational cancers, severe occupational traumatic injuries, and occupational cardiovascular diseases. Lung diseases considered included silicosis, asbestosis, lung cancer mesothelioma, coal workers' pneumoconiosis, byssinosis, occupational asthma, hypersensitivity pneumonitis, asphyxiation, irritation, pulmonary edema, brucellosis, psitticosis, anthrax, mycobacterioses, histoplasmosis, aspergillosis, and coccidioidomycosis. Occupational cancers were discussed as they occur in the lung, pleura, peritoneum, bladder, kidneys, blood, nasal cavity, skin, nasal sinuses, and liver.

  7. Malignant Mesothelioma of the Pericardium: A Report of Two Different Presentations

    Directory of Open Access Journals (Sweden)

    Pattarapong Makarawate

    2013-01-01

    Full Text Available Malignant mesothelioma of the pericardium is a rare and fatal condition that clinicians should be aware of due to its variability of clinical manifestation. The diagnosis may be delayed as a result of delayed treatment. Here, we report two cases of malignant pericardial mesothelioma with two different clinical aspects: cardiac tamponade and mimic tuberculous pericarditis. Both patients: may have indirect exposure to asbestos. Despite chemotherapy, both patients died at 2 weeks and 3 months after the diagnosis. Malignant mesothelioma of the pericardium is fatal, has a variety of presentation, and may not be related to asbestosis exposure.

  8. [Asbestos carcinogenesis from clinical and hypothetical viewpoints].

    Science.gov (United States)

    Luther, R; Preisler, J; Bärsch, J

    1986-04-01

    On the basis of a case of mesothelioma of the pleura in a 28-year-old female who among our patients had the longest survival time after establishment of the diagnosis (31 months) the authors adopt a definite attitude to the problems of asbestosis. It can be regarded as ascertained that after asbest exposition a systemic contamination of the organism occurs. Apart from the inhalative intake further possibilities of the asbest fibre incorporation and the elimination are referred to. As to the cancerogenesis of asbest-induced malignomas the existing theories appear at present still insufficient; analogies to Virchow's irritation theory are possible in the serosa tumours.

  9. Usefulness of CT in diffuse pleural disease

    Energy Technology Data Exchange (ETDEWEB)

    Ashizawa, Kazuto; Uetani, Masataka; Mori, Masaichi; Matsunaga, Naofumi; Hayashi, Kuniaki; Kawahara, Katsunobu; Ayabe, Kimiji; Tsuda, Nobuo (Nagasaki Univ. (Japan). School of Medicine)

    1993-01-01

    Alterations of the pleura and extrapleural fat were assessed by CT in 114 patients with diffuse pleural disease. The diseases included malignant pleural mesothelioma, pleuritis carcinomatosa, acute and chronic empyema, asbestosis and transudatory effusion. The pleural changes were classified into five types according to the degree, extent and contour of pleural thickening. Each type was relatively specific for the diagnosis of diffuse pleural diseases. Increased thickness of the extrapleural fat was seen in malignant pleural disease and empyema, and homogenous increased attenuation of extrapleural was a relatively characteristic finding in acute empyema. CT was useful in evaluating diffuse pleural disease. (author).

  10. Inhaled dust and disease

    Energy Technology Data Exchange (ETDEWEB)

    Holt, P.F.

    1987-01-01

    This book discusses the following: the respiratory system; respirable dust; the fate of inhaled dust; translocation and some general effects of inhaled dust; silicosis; experimental research on silica-related disease; natural fibrous silicates; asbestos dust levels and dust sources; asbestos-related diseases - asbestosis, lung cancer, mesothelioma and other diseases, cancers at sites other than lung and pleura; experimental research relating to asbestos-related diseases; asbestos hazard - mineral types and hazardous occupations, neighbourhood and domestic hazard; silicates other than asbestos-man-made mineral fibres, mineral silicates and cement; metals; coal mine dust, industrial carbon and arsenic; natural and synthetic organic substances; dusts that provoke allergic alveolitis; tobacco smoke.

  11. Asbestos-related diseases in Thailand and review literature.

    Science.gov (United States)

    Subhannachart, Ponglada; Dumavibhat, Narongpon; Siriruttanapruk, Somkiat

    2012-08-01

    Asbestos is a harmful substance that can cause both malignancy and non-malignancy in humans. Although it has been used in Thailand for several years, few cases of asbestos-related diseases were reported. Concerning about high consumption and long exposure of asbestos in the country, the incurable but preventable diseases caused by asbestos will be the health problem in the near future. The authors presented 2 cases with asbestos-related diseases, one diagnosed as malignant mesothelioma and the other as asbestosis.

  12. High-resolution CT in the evaluation of occupational and environmental disease

    Energy Technology Data Exchange (ETDEWEB)

    Akira, M. [National Kinki Central Hospital for Chest Diseases, Osaka (Japan). Dept. of Radiology

    2002-01-01

    CT has an increasing role in the radiologic evaluation of occupational/environmental lung disease. The high-resolution CT (HRCT) findings of silicosis, mixed dust pneumoconiosis, coal worker's pneumoconiosis, graphite pneumoconiosis, asbestosis, talcosis, welder's lung, berylliosis, aluminum lung, and hard metal pneumoconiosis are described. Hypersensitivity pneumonitis and lung damage caused by exposure to toxic fumes also are described. HRCT pathologic correlation with each type of pneumoconiosis is focused on. HRCT is useful in achieving an accurate categorization of the parenchymal changes in each type of pneumoconiosis.

  13. Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases.

    Science.gov (United States)

    Klebe, Sonja; Brownlee, Noel A; Mahar, Annabelle; Burchette, James L; Sporn, Thomas A; Vollmer, Robin T; Roggli, Victor L

    2010-03-01

    Sarcomatoid mesothelioma is the least common, but most aggressive of the three major histological types of mesotheliomas. This study comprises 326 cases of sarcomatoid mesotheliomas among 2000 consecutive malignant mesothelioma cases received in consultation (16%). Patients included 312 men (96%) and 14 women (4%), with a median age of 70 years (range 41-94 years). Most tumors were pleural (319; 98%), and 7 were peritoneal (2%). Some desmoplastic features were identified in 110 cases (34%), and 70 (21%) were classified as desmoplastic. Rare subtypes included two cases with a lymphohistiocytoid pattern (mesotheliomas (2%). Labeling for cytokeratins (CKs) was observed in 261/280 cases (93%), and for calretinin and vimentin in 31 and 91%, respectively. Pleural plaques were present in 79% of cases for which information was available, and asbestosis was diagnosed in 34/127 cases (27%). Median survival was 3.5 months. Fiber analysis was performed in 61 cases. The median asbestos body count was 1640/g wet lung tissue (by light microscopy). Amosite fibers were the most commonly identified fibers using energy-dispersive X-ray analysis and were significantly higher in the sarcomatoid cases, as were uncoated fibers using scanning electron microscopy. This study represents the largest series of sarcomatoid and desmoplastic malignant mesotheliomas to date and confirms the diagnostic usefulness of CK immunohistochemistry. The relationship with asbestos exposure--particularly amosite--and an association with pleural plaques and less often asbestosis is confirmed.

  14. Clinical and radiological observations on asbestos-related pathology

    Energy Technology Data Exchange (ETDEWEB)

    Bohlig, H.; Hain, E.

    1980-01-01

    The papers in this session, which are summarized briefly, do not cover the wide range of radiological and clinical problems resulting from inhalation of asbestos dust. Pleural effusions are found in persons exposed occupationally to asbestos, even in the absence of asbestosis, but they are difficult to attribute to such exposure. Asbestosis of the lung shows no striking symptoms and can also be diagnosed only after all other possibilities have been excluded. There are no convincing or striking morphological peculiarities that suggest that an 'asbestos lung cancer' exists. Mesotheliomas of the pleura and of the peritoneum are usually resistant to therapy of any kind, although several possibilities are discussed. Radiological surveillance is presented as being still the most effective and reliable method for medical surveillance of asbestos workers. Circumscribed pleural thickening is benign but a good indicator of exposure to mineral dusts. Diffuse pleural thickening occurs frequently in nonexposed groups and cannot, therefore, be used as an indication of exposure; however, it cannot yet be ruled out as being significant epidemiologically.

  15. Asbestos and other ferruginous bodies: their formation and clinical significance.

    Science.gov (United States)

    Churg, A. M.; Warnock, M. L.

    1981-01-01

    Analyses of asbestos bodies from the general population have confirmed that these structures, like asbestos bodies from the lungs of asbestos workers, contain an asbestos core. In members of the general population this core is almost always an amphibole, whereas asbestos workers may have bodies formed on either amphibole or chrysotile. Most adults have a few bodies, and increasing numbers are seen in blue collar workers and others who handle small amounts of the fiber, with the highest levels being seen in asbestos workers. In men with minimal or extensive occupational exposure, asbestos bodies are formed on the commercial fibers, amosite and crocidolite, whereas women also form a significant number of bodies on the noncommercial fibers, anthophyllite and tremolite. These findings suggest that women may be exposed to specific asbestos-containing products, eg, cosmetic talc. The commercial fibers found in women and white collar men probably reflect atmospheric pollution with asbestos. At the highest levels of exposure, numbers of asbestos bodies correlate in a general way with the presence of asbestosis, although no precise value has been determined above which asbestosis is always found. In persons with much lower or environmental exposure, there does not appear to be any correlation between numbers of bodies and disease, in particular between numbers of bodies and carcinoma of the lung or gastrointestinal tract. The situation for mesothelioma is uncertain. Images Figure 1 Figure 2 Figure 3 PMID:6101235

  16. Clearance of /sup 99m/-technetium-labelled DTPA in asbestos-exposed subjects without clinical or radiological evidence of interstitial lung disease

    Energy Technology Data Exchange (ETDEWEB)

    Gellert, A.R.; Langford, J.A.; Winter, R.J.; Lewis, C.A.; Tolfree, S.E.; Rudd, R.M.

    1985-01-01

    The half-time clearance of an inhaled aerosol of /sup 99m/-technetium-labelled diethylene triamine pentacetate from lung to blood (T1/2LB) was measured using a gamma camera in 20 non-smoking subjects (mean age 54, range 40-69 years) with previous occupational asbestos exposure, but no clinical or radiological evidence of asbestosis, and 20 non-smoking normal subjects (mean age 54, range 40-62). Mean T1/2LB was 44.7 minutes (range 12-102) in exposed subjects, significantly less than 57.2 minutes (range 30.5-109) in normal subjects (P less than 0.05). There was no correlation between age and T1/2LB in either group. In exposed subjects T1/2LB showed a weak rank correlation with the membrane component of DLco (Dm) (r = 0.40, P less than 0.05) but no significant correlation with FVC, TLC, DLco, Kco, resting Pao2 or change in Pao2 on exercise. In six exposed subjects T1/2LB was shorter than in any of the normal subjects. These six did not differ from the other 14 exposed subjects in any physiological variables. T1/2LB is abnormal in some asbestos-exposed subjects without clinical, radiological or physiological evidence of asbestosis. Follow-up will show whether it is an early indicator of development of interstitial lung disease.

  17. Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases

    Science.gov (United States)

    Jiang, Zhaoqiang; He, Xianglei; Yu, Min; Chen, Riping; Chen, Junqiang; Ru, Guoqing; Chen, Yuan; Chen, Wanyuan; Zhu, Lijin; Li, Tao; Zhang, Yixiao; Guo, Xinnian; Yin, Xianhong; Zhang, Xing

    2017-01-01

    High-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and is one of the most intriguing molecules in inflammatory disorders and cancers. Notably, HMGB1 is a potential therapeutic target and novel biomarker in related diseases. However, the diagnostic value of HMGB1 for benign and malignant asbestos-related diseases (ARDs) remains unclear. In this work, we detected preoperative serum HMGB1 levels in Chinese asbestos-exposed (AE) and ARDs populations and further evaluated the diagnostic value of HMGB1 in patients with certain types of ARDs, including those with pleural plaques, asbestosis, or malignant mesothelioma (MM). The experimental data presented that the serum level of HMGB1 was significantly elevated in AE and ARDs subjects. Our findings indicated that serum HMGB1 is a sensitive and specific biomarker for discriminating asbestosis- and MM-affected individuals from healthy or AE individuals. In addition, serum matrix metalloproteinases 2 and 9 are not correlated with HMGB1 in ARDs. Thus, our study provides supporting evidence for HMGB1 as a potential biomarker either for the clinical diagnosis of high-risk AE cohorts or for evaluating ARDs. PMID:28348451

  18. Exporting asbestos: disease and policy in the developing world.

    Science.gov (United States)

    Huncharek, M

    1993-01-01

    The health effects of asbestos are well known, with lung cancer, mesothelioma and asbestosis recognized as the most common causes of mortality and morbidity among exposed populations. Recognition of these hazards coupled with an explosion of litigation against asbestos manufacturers brought by injured workers has resulted in declining markets for this commodity in the U.S. and other Western democracies. With Western markets for asbestos decreasing, the developing world has become the target of asbestos exporters in an attempt to revitalize an industry in decline. This paper discusses the trends in worldwide asbestos markets over the last two decades and the serious health implications of policies directed at establishing viable markets for this commodity in developing nations.

  19. Does pneumoconiosis of dental technician cause to calcific pleural lesions? (Case report

    Directory of Open Access Journals (Sweden)

    Abdurrahman ŞENYİĞİT

    2009-03-01

    Full Text Available The articles about various pneumoconiosis in dental technicians who work in inconvenient conditions have been increasing in recent years. Exposure to dust and fume that occur during the dental procedure may play role in pneumoconiosis of dental technicians.A 53 years old male patient conveyed that he has worked in dental prosthesis procedures for 22 years (1968-1990.Environmental asbestosis was not established in the history of the case but there were calcified pleural plaques in the chest x-ray graphy.There were appearance of calcific asbest plaques in many section of thorax CT.A case of pneumoconiosis in dental technician who work in unadequate preventive conditions was reported in this paper. Probably ,exposure to the asbest fibers that occurs during the procedure of dental prosthesis were the main reason for developing calcific pleural lesions.

  20. Asbestos-related pleuropulmonary diseases: iconographic essay; Alteracoes pleurais e parenquimatosas relacionadas a exposicao ao asbesto: ensaio iconografico

    Energy Technology Data Exchange (ETDEWEB)

    Gustavo de Souza Portes Meirelles [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil); Rodrigues, Reynaldo Tavares; Nery, Luiz Eduardo [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil). Dept. de Diagnostico por Imagem; Bagatin, Ericson [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Dept. de Medicina Preventiva e Social; Terra-Filho, Mario [Instituto do Coracao (InCor). Sao Paulo, SP (Brazil)]. E-mail: gmeirelles@gmail.com

    2007-07-01

    The aim of this study is to illustrate the main imaging findings of asbestos-related diseases. Pleural and pulmonary asbestos-related diseases range from benign conditions, like pleural effusion and pleural plaques, to some neoplasias, such as lung cancer and malignant mesothelioma. Pleural effusion is the earliest finding after asbestos exposure, but the imaging findings are not specific. Diffuse pleural thickening involves the visceral pleura and pleural plaques are considered to be hallmarks of exposure. Asbestosis is the pulmonary fibrosis due to asbestos. Rounded atelectasis is a peripheral lung collapse in these individuals, generally related to pleural disease. Some neoplasias, like lung carcinoma and pleural mesothelioma, are more prevalent in asbestos-exposed subjects. (author)

  1. Doenças asbesto-relacionadas Asbestos-related diseases

    Directory of Open Access Journals (Sweden)

    Mário Terra Filho

    2006-05-01

    Full Text Available Apresenta-se uma revisão bibliográfica das doenças asbesto-relacionadas. São discutidos e atualizados os critérios diagnósticos, as características radiológicas, tomográficas e funcionais das alterações benignas de pleura, da asbestose, do câncer de pulmão ocupacional e do mesotelioma maligno de pleura.This chapter presents a bibliographic review of asbestos-related diseases. The latest diagnostic, radiological, computed tomography and lung function aspects of benign pleural disease, asbestosis, occupational lung cancer and mesothelioma are discussed.

  2. [Industrial injury insurance system in the UK].

    Science.gov (United States)

    Muramatsu, Keiji; Kubo, Tatsuhiko; Fujino, Yoshihisa; Matsuda, Shinya

    2013-12-01

    The Industrial Injuries Disablement Benefit (IIDB) is a benefit for people who are disabled either as a result of an accident at work or because of a prescribed disease. IIDB does not cover the self-employed, military personnel, or certain kinds of trainees. "Prescribed diseases" are defined by the Department of Work and Pension in a list of diseases covered by IIDB. Delivery of medical services, such as the medical treatment benefit in Japan, is not included in this scheme because most medical services are provided for in the scheme of the National Health Service (NHS). Prevention Projects, such as the Follow-up Medical Examination Benefits in Japan, are also not included. Benefits for people who have Pneumoconiosis (including asbestosis) are provided in the IIDB scheme.

  3. Clinical study of asbestos-related lung cancer in Japan with special reference to occupational history.

    Science.gov (United States)

    Kishimoto, Takumi; Gemba, Kenichi; Fujimoto, Nobukazu; Onishi, Kazuo; Usami, Ikuji; Mizuhashi, Keiichi; Kimura, Kiyonobu

    2010-05-01

    A total of 152 patients with asbestos-related lung cancer recognized by the criteria of Japanese compensation law for asbestos-related diseases were examined and compared with 431 patients with non-asbestos-related lung cancer. Male comprised 96% of patients. Ages ranged from 50 to 91 years with a median of 72 years. Eighty-nine percent were smokers or ex-smokers. Almost all patients had occupational histories of asbestos exposure. The median duration of asbestos exposure was 31 years and the median latency period was 47 years. Thirty-four percent of patients exhibited asbestosis and 81% exhibited pleural plaques by radiography. Regarding asbestos particles in the lung for 73 operated or autopsied patients, 62% had more than 5,000 particles per gram. On the other hand, 100% of non-asbestos-related lung cancer patients had <5000 particles per gram with a median of 554 particles. The number of asbestos bodies in the lung, male gender, absence of symptoms, smoking index, and early stage of cancer were significantly much more than those of non-asbestos-related lung cancer. In this study, a diagnosis of asbestos-related lung cancer was made in 34% of patients by asbestosis, in 62% by presence of both pleural plaques and more than 10 years' occupational asbestos exposure, and in 4% by more than 5000 asbestos particles per gram of lung tissue. Occupational histories, duration of asbestos exposure, and pleural plaques are common categories for the recognition of asbestos-related lung cancer in Japan.

  4. [Expectations after ban on asbestos].

    Science.gov (United States)

    Sarić, Marko

    2009-11-01

    This article brings a brief review of asbestos exposure and asbestos-related diseases in Croatia in view of the asbestos ban. The first cases of asbestosis were diagnosed in workers from an asbestos-cement factory in 1961. Between 1990 and 2007, 403 cases of asbestosis had been registered as occupational disease: 300 with parenchymal fibrosis and the rest with parenchymal and pleural changes, or pleural plaques. As a rule, asbestos-related changes were diagnosed at an early stage thanks to regular checkups of the exposed workers. Pleural plaques, considered to be the consequence of asbestos exposure, were also occasionally found in subjects who lived in areas with asbestos processing plants, but were not occupationally exposed. Early epidemiological studies on respiratory and gastrointestinal tract tumours in areas with an asbestos processing plant (1994) and an asbestos-cement plant (1995, 1996) focused on the occurrence of malignant tumours in persons exposed to asbestos at work or in the environment. More recently, the focus has shifted to the malignant pleural mesotelioma (MPM). An epidemiological study published in 2002 showed that the MPM incidence was significantly higher in the coastal area than in the rest of the country. About two thirds of patients with the tumour were occupationally exposed to asbestos. This uneven distribution of the tumour incidence is obviously related to shipbuilding and other industrial sources of asbestos exposure located in the coastal Croatia. Sources of environmental exposure to asbestos also have to be taken into account. The second part of this article ventures into the issues ahead of us, after asbestos has been banned in the country. The long latency period of cancers, and particularly of asbestos-related mesothelioma, implies that the incidence of this tumour will not drop over the next few decades. In Croatia, the average annual rate of MPM between 1991 and 2006 was 40, and ranged between 20 in 1991 to 61 in 1999. In 2006

  5. Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions

    Directory of Open Access Journals (Sweden)

    Stevens John R

    2008-08-01

    Full Text Available Abstract Background Although exposure to asbestos is now regulated, patients continue to be diagnosed with mesothelioma, asbestosis, fibrosis and lung carcinoma because of the long latent period between exposure and clinical disease. Asbestosis is observed in approximately 200,000 patients annually and asbestos-related deaths are estimated at 4,000 annually1. Although advances have been made using single gene/gene product or pathway studies, the complexity of the response to asbestos and the many unanswered questions suggested the need for a systems biology approach. The objective of this study was to generate a comprehensive view of the transcriptional changes induced by crocidolite asbestos in A549 human lung epithelial cells. Results A statistically robust, comprehensive data set documenting the crocidolite-induced changes in the A549 transcriptome was collected. A systems biology approach involving global observations from gene ontological analyses coupled with functional network analyses was used to explore the effects of crocidolite in the context of known molecular interactions. The analyses uniquely document a transcriptome with function-based networks in cell death, cancer, cell cycle, cellular growth, proliferation, and gene expression. These functional modules show signs of a complex interplay between signaling pathways consisting of both novel and previously described asbestos-related genes/gene products. These networks allowed for the identification of novel, putative crocidolite-related genes, leading to several new hypotheses regarding genes that are important for the asbestos response. The global analysis revealed a transcriptome that bears signatures of both apoptosis/cell death and cell survival/proliferation. Conclusion Our analyses demonstrate the power of combining a statistically robust, comprehensive dataset and a functional network genomics approach to 1 identify and explore relationships between genes of known importance

  6. The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis

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    Seok-Jo Kim

    2015-09-01

    Full Text Available Convincing evidence has emerged demonstrating that impairment of mitochondrial function is critically important in regulating alveolar epithelial cell (AEC programmed cell death (apoptosis that may contribute to aging-related lung diseases, such as idiopathic pulmonary fibrosis (IPF and asbestosis (pulmonary fibrosis following asbestos exposure. The mammalian mitochondrial DNA (mtDNA encodes for 13 proteins, including several essential for oxidative phosphorylation. We review the evidence implicating that oxidative stress-induced mtDNA damage promotes AEC apoptosis and pulmonary fibrosis. We focus on the emerging role for AEC mtDNA damage repair by 8-oxoguanine DNA glycosylase (OGG1 and mitochondrial aconitase (ACO-2 in maintaining mtDNA integrity which is important in preventing AEC apoptosis and asbestos-induced pulmonary fibrosis in a murine model. We then review recent studies linking the sirtuin (SIRT family members, especially SIRT3, to mitochondrial integrity and mtDNA damage repair and aging. We present a conceptual model of how SIRTs modulate reactive oxygen species (ROS-driven mitochondrial metabolism that may be important for their tumor suppressor function. The emerging insights into the pathobiology underlying AEC mtDNA damage and apoptosis is suggesting novel therapeutic targets that may prove useful for the management of age-related diseases, including pulmonary fibrosis and lung cancer.

  7. [Evaluation of rounded atelectasis induced by exposure to asbestos].

    Science.gov (United States)

    Kishimoto, Takumi; Gemba, Kenichi; Fujimoto, Nobukazu; Nishi, Hideyuki; Ozaki, Shinji

    2008-09-01

    We encountered 19 patients of rounded atelectasis induced by exposure to asbestos from 2000 to 2007. All patients were men whose ages arranged from 60 to 89 years with a mean of 74.2 years. Twenty rounded atelectasis were present in the right lung and 5 in the left lung. Five patients had 2 rounded atelectasis. In 21 rounded atelectasis were found in Segment 10 and while other 2 found in S1 and each in S5 and 9. Eleven patients were diagnosed with no symptoms through medical examinations. Other 8 patients complained of dyspnea, chest pain and cough. Thirteen patients complicated with benign asbestos pleurisy and only 3 patients accompanied asbestosis. Eighteen patients (95%) displayed pleural plaques and 15 patients with calcified plaques. Ten patients had been exposed to asbestos in the shipyards and 4 in construction works and other 5 patients had also exposed by occupational exposure to asbestos. The mean period of exposure to asbestos was 26.6 years and the mean latency periods from the first asbestos exposure to the diagnosis of rounded atelectasis were 51.6 years. An autopsied patient had 18,100 asbestos bodies per 1 g of dry lung tissue which meant the heavy asbestos exposure. High incidence of pleural plaques and long period of latency from the first exposure to the appearance of rounded atelectasis in this study suggested that rounded atelectasis might appear less high-dose exposure to asbestos than former patients who were reported 6 years ago.

  8. Clinical Investigation of Benign Asbestos Pleural Effusion.

    Science.gov (United States)

    Fujimoto, Nobukazu; Gemba, Kenichi; Aoe, Keisuke; Kato, Katsuya; Yokoyama, Takako; Usami, Ikuji; Onishi, Kazuo; Mizuhashi, Keiichi; Yusa, Toshikazu; Kishimoto, Takumi

    2015-01-01

    There is no detailed information about benign asbestos pleural effusion (BAPE). The aim of the study was to clarify the clinical features of BAPE. The criteria of enrolled patients were as follows: (1) history of asbestos exposure; (2) presence of pleural effusion determined by chest X-ray, CT, and thoracentesis; and (3) the absence of other causes of effusion. Clinical information was retrospectively analysed and the radiological images were reviewed. There were 110 BAPE patients between 1991 and 2012. All were males and the median age at diagnosis was 74 years. The median duration of asbestos exposure and period of latency for disease onset of BAPE were 31 and 48 years, respectively. Mean values of hyaluronic acid, adenosine deaminase, and carcinoembryonic antigen in the pleural fluid were 39,840 ng/mL, 23.9 IU/L, and 1.8 ng/mL, respectively. Pleural plaques were detected in 98 cases (89.1%). Asbestosis was present in 6 (5.5%) cases, rounded atelectasis was detected in 41 (37.3%) cases, and diffuse pleural thickening (DPT) was detected in 30 (27.3%) cases. One case developed lung cancer (LC) before and after BAPE. None of the cases developed malignant pleural mesothelioma (MPM) during the follow-up.

  9. Clinical Investigation of Benign Asbestos Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Nobukazu Fujimoto

    2015-01-01

    Full Text Available There is no detailed information about benign asbestos pleural effusion (BAPE. The aim of the study was to clarify the clinical features of BAPE. The criteria of enrolled patients were as follows: (1 history of asbestos exposure; (2 presence of pleural effusion determined by chest X-ray, CT, and thoracentesis; and (3 the absence of other causes of effusion. Clinical information was retrospectively analysed and the radiological images were reviewed. There were 110 BAPE patients between 1991 and 2012. All were males and the median age at diagnosis was 74 years. The median duration of asbestos exposure and period of latency for disease onset of BAPE were 31 and 48 years, respectively. Mean values of hyaluronic acid, adenosine deaminase, and carcinoembryonic antigen in the pleural fluid were 39,840 ng/mL, 23.9 IU/L, and 1.8 ng/mL, respectively. Pleural plaques were detected in 98 cases (89.1%. Asbestosis was present in 6 (5.5% cases, rounded atelectasis was detected in 41 (37.3% cases, and diffuse pleural thickening (DPT was detected in 30 (27.3% cases. One case developed lung cancer (LC before and after BAPE. None of the cases developed malignant pleural mesothelioma (MPM during the follow-up.

  10. Acute exacerbations of fibrotic interstitial lung disease.

    Science.gov (United States)

    Churg, Andrew; Wright, Joanne L; Tazelaar, Henry D

    2011-03-01

    An acute exacerbation is the development of acute lung injury, usually resulting in acute respiratory distress syndrome, in a patient with a pre-existing fibrosing interstitial pneumonia. By definition, acute exacerbations are not caused by infection, heart failure, aspiration or drug reaction. Most patients with acute exacerbations have underlying usual interstitial pneumonia, either idiopathic or in association with a connective tissue disease, but the same process has been reported in patients with fibrotic non-specific interstitial pneumonia, fibrotic hypersensitivity pneumonitis, desquamative interstitial pneumonia and asbestosis. Occasionally an acute exacerbation is the initial manifestation of underlying interstitial lung disease. On biopsy, acute exacerbations appear as diffuse alveolar damage or bronchiolitis obliterans organizing pneumonia (BOOP) superimposed upon the fibrosing interstitial pneumonia. Biopsies may be extremely confusing, because the acute injury pattern can completely obscure the underlying disease; a useful clue is that diffuse alveolar damage and organizing pneumonia should not be associated with old dense fibrosis and peripheral honeycomb change. Consultation with radiology can also be extremely helpful, because the fibrosing disease may be evident on old or concurrent computed tomography scans. The aetiology of acute exacerbations is unknown, and the prognosis is poor; however, some patients survive with high-dose steroid therapy.

  11. [What are the tools for post-occupational follow-up, how should they be performed and what are their performance, limits and benefit/risk ratio? Chest X-Ray and CT scan].

    Science.gov (United States)

    Ferretti, G

    2011-06-01

    Chest radiography and computed tomography (CT) are the two radiological techniques used for the follow-up of people exposed to asbestos. Since the last conference of consensus (1999), the scientific literature has primarily covered high-resolution CT and high-resolution volume CT (HR-VCT). We consider in turn the contribution of digital thoracic radiography, recommendations for the performance of HR-VCT to ensure the quality of examination while controlling the delivered radiation dose, and the need to refer to the "CT atlas of benign diseases related to asbestos exposure", published by a group of French experts in 2007, for interpretation. The results of the published studies concerning radiography or CT are then reviewed. We note the great interobserver variability in the recognition of pleural plaques and asbestosis, indicating the need for adequate training of radiologists, and the importance of defining standardized, quantified criteria for CT abnormalities. The very low agreement between thoracic and general radiologists must be taken into account. The reading of CT scans in cases of occupational exposure to asbestos should be entrusted to thoracic radiologists or to general radiologists having validated specific training. A double interpretation of CT could be considered in medicosocial requests. CT is more sensitive than chest radiography in the detection of bronchial carcinoma but generates a great number of false positive results (96 to 99%). No scientific data are available to assess the role of imaging by either CT or chest radiography in the early detection of mesothelioma.

  12. Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease.

    Science.gov (United States)

    Gaffney, Adam; Christiani, David C

    2015-06-01

    Environmental and occupational pulmonary diseases impose a substantial burden of morbidity and mortality on the global population. However, it has been long observed that only some of those who are exposed to pulmonary toxicants go on to develop disease; increasingly, it is being recognized that genetic differences may underlie some of this person-to-person variability. Studies performed throughout the globe are demonstrating important gene-environment interactions for diseases as diverse as chronic beryllium disease, coal workers' pneumoconiosis, silicosis, asbestosis, byssinosis, occupational asthma, and pollution-associated asthma. These findings have, in many instances, elucidated the pathogenesis of these highly complex diseases. At the same time, however, translation of this research into clinical practice has, for good reasons, proceeded slowly. No genetic test has yet emerged with sufficiently robust operating characteristics to be clearly useful or practicable in an occupational or environmental setting. In addition, occupational genetic testing raises serious ethical and policy concerns. Therefore, the primary objective must remain ensuring that the workplace and the environment are safe for all.

  13. National occupational health service policies and programs for workers in small scale industries in China

    Energy Technology Data Exchange (ETDEWEB)

    Su Zhi; Wang Sheng; Levine, S.P.

    2000-07-01

    Over the 14 years since economic reform began, and the restructuring of the economy to encourage international trade, a large number of township enterprises have been developed and put into operation in the Peoples Republic of China. In this paper, a report is given on a sample survey in 30 counties in 1990, which showed that 82.69% of rural industrial enterprises had at least one type of occupational hazard in their work environments. Workers engaged in at least one type of hazardous working environment accounted for 33.91% of the blue-collar workers. Physical examinations were performed for seven types of occupational diseases: silicosis, coal worker's pneumoconiosis, asbestosis, chronic lead poisoning, benzene analogs poisoning, chronic chromium poisoning, and noise-induced hearing loss. The total detectable rate of the seven types of occupational diseases was 4.4% among those workers. In addition, 11% had illnesses suspected of being caused by occupational exposures. Most township enterprises do not provide basic occupational health services.

  14. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

    Science.gov (United States)

    Sanchez, Vanesa C; Pietruska, Jodie R; Miselis, Nathan R; Hurt, Robert H; Kane, Agnes B

    2009-01-01

    Human diseases associated with exposure to asbestos fibers include pleural fibrosis and plaques, pulmonary fibrosis (asbestosis), lung cancer, and diffuse malignant mesothelioma. The critical determinants of fiber bioactivity and toxicity include not only fiber dimensions, but also shape, surface reactivity, crystallinity, chemical composition, and presence of transition metals. Depending on their size and dimensions, inhaled fibers can penetrate the respiratory tract to the distal airways and into the alveolar spaces. Fibers can be cleared by several mechanisms, including the mucociliary escalator, engulfment, and removal by macrophages, or through splitting and chemical modification. Biopersistence of long asbestos fibers can lead to inflammation, granuloma formation, fibrosis, and cancer. Exposure to synthetic carbon nanomaterials, including carbon nanofibers and carbon nanotubes (CNTs), is considered a potential health hazard because of their physical similarities with asbestos fibers. Respiratory exposure to CNTs can produce an inflammatory response, diffuse interstitial fibrosis, and formation of fibrotic granulomas similar to that observed in asbestos-exposed animals and humans. Given the known cytotoxic and carcinogenic properties of asbestos fibers, toxicity of fibrous nanomaterials is a topic of intense study. The mechanisms of nanomaterial toxicity remain to be fully elucidated, but recent evidence suggests points of similarity with asbestos fibers, including a role for generation of reactive oxygen species, oxidative stress, and genotoxicity. Considering the rapid increase in production and use of fibrous nanomaterials, it is imperative to gain a thorough understanding of their biologic activity to avoid the human health catastrophe that has resulted from widespread use of asbestos fibers.

  15. Contribution of occupational risk factors to the global burden of disease - a summary of findings

    Energy Technology Data Exchange (ETDEWEB)

    Fingerhut, M.; Driscoll, T.; Nelson, D.I.; Concha-Barrientos, M.; Punnett, L.; Pruss-Ustin, A.; Steenland, K.; Leigh, J.; Corvalan, C. [NIOSH, Cincinnati, OH (United States)

    2005-07-01

    The World Health Organization conducted a comparative risk assessment to ascertain the contributions of 26 risk factors to the global burden of disease. Five occupational risk factors accounted for an estimated 37% of back pain, 16% of hearing loss, 13% of chronic obstructive pulmonary disease, 11% of asthma, 9% of lung cancer, 8% of injuries, and 2% of leukemia worldwide. Virtually all cases of silicosis, asbestosis, and coal workers' pneumoconiosis were work-related. Contaminated sharps injuries accounted for 40% of hepatitis B, 40% of hepatitis C, and 4% of HIV/AlDS infections among health care workers. Data limitations, primarily in developing countries, prevented the inclusion of other major occupational risk factors. These selected occupational risks accounted for about 850,000 deaths and 24 million years of healthy life lost each year. The deaths due to these selected occupational risk factors constitute only 43% of the International Labour Organization's estimate of 2 million deaths worldwide due to work-related risks.

  16. National Occupational Health Service policies and programs for workers in small-scale industries in China.

    Science.gov (United States)

    Zhi, S; Sheng, W; Levine, S P

    2000-01-01

    Over the 14 years since economic reform began, and the restructuring of the economy to encourage international trade, a large number of township enterprises have been developed and put into operation in the Peoples Republic of China. From 1978 to 1991, the number of enterprises has increased 11.5 times; the number of employees has increased 2.4 times; the fixed assets have increased 13.7 times; and the value of the total output has increased 22.5 times. In this article, a report is given on a sample survey in 30 counties in 1990, which showed that 82.69% of rural industrial enterprises had at least one type of occupational hazard in their work environments. Workers engaged in at least one type of hazardous working environment accounted for 33.91% of the blue-collar workers. Physical examinations were performed for seven types of occupational diseases: silicosis, coal worker's pneumoconiosis, asbestosis, chronic lead poisoning, benzene analogs poisoning, chronic chromium poisoning, and noise-induced hearing loss. The total detectable rate of the seven types of occupational diseases was 4.4% among those workers. In addition, 11% had illnesses suspected of being (though not proven to be) caused by occupational exposures. Most township enterprises do not provide basic occupational health services. The coverage of five routine occupational health service activities provided for township enterprises were very limited, from 1.4 to 36%.

  17. Prospective study of asbestos-related diseases incidence cases in primary health care in an area of Barcelona province

    Science.gov (United States)

    2010-01-01

    Background Asbestos related diseases include a number of conditions due to inhalation of asbestos fibres at work, at home or in the environment, such as pleural mesothelioma, asbestosis and calcified pleural plaques. Few epidemiological studies have established the incidence of asbestos related diseases in our area. The present proposal is based on a retrospective study externally funded in 2005 that is currently taking place in the same area and largely carried out by the same research team. The aim of the study is to achieve a comprehensive and coordinated detection of all new cases of Asbestos Related Diseases presenting to primary care practitioners. Methods/design This is a multicentre, multidisciplinary and pluri-institutional prospective study. Setting 12 municipalities in the Barcelona province within the catchment area of the health facilities that participate in the study. Sample This is a population based study, of all patients presenting with diseases caused by asbestos in the study area. Measurements A clinical and epidemiological questionnaire will be filled in by the trained researchers after interviewing the patients and examining their clinical reports. Discussion Data on the incidence of the different Asbestos Related Diseases in this area will be obtained and the most plausible exposure source and space-time-patient profile will be described. The study will also improve the standardization of patient management, the coordination between health care institutions and the development of preventive activities related with asbestos exposure and disease. PMID:20412567

  18. [Need for occupational and environmental allergology in occupational health - the 45th Japanese society of Occupational and Environmental Allergy Annual Meeting 2014 in Fukuoka].

    Science.gov (United States)

    Kishikawa, Reiko; Oshikawa, Chie

    2014-12-01

    The 45th Japanese Society of Occupational and Environmental Allergy (OEA) Annual Meeting 2014 was held in Fukuoka city in conjunction with a technical course for occupational health physicians to learn occupational and environmental diseases more deeply. Allergic reaction due to low concentrations of chemical and biological materials is important in toxicological diseases due to highly concentrated chemical materials in the field of occupational and environmental medicine. In this paper we describe the activities of the OEA, which was established in 1970 and has completely cured patients with severe occupational asthma, such as the regional Konjac asthma in Gunma prefecture and Sea Squirt asthma in Hiroshima prefecture. Regard for the occupational environment will prevent the onset and/or exacerbation of allergic occupational disease in individual employees with allergy. Occupational cancer of the bile duct and asbestosis are also current, serious issues that should be resolved as soon as possible. It is desirable for the occupational health physician to have a large stock of knowledge about toxicological and allergic diseases in various occupational settings to maintain the health and safety of workers.

  19. Malignant mesothelioma in Hong Kong.

    Science.gov (United States)

    Chang, Kwok C; Leung, Chi C; Tam, Cheuk M; Yu, Wai C; Hui, David S; Lam, Wah K

    2006-01-01

    Malignant mesothelioma (mesothelioma) is rare. We conducted the first systematic study of the epidemiology of mesothelioma in Hong Kong from 1988 to May 2002 by reviewing medical records. Mesothelioma patients were identified from the database of 12 out of 20 hospitals that would have admitted mesothelioma patients territory-wide. These 12 hospitals served 73% of the total hospital bed-years of the 20 hospitals. We identified 67 mesothelioma patients. The estimated annual incidence was one per million, which was similar to the background incidence of one to two per million among Caucasians. Occupational history was available in 43 subjects. Three quarters of mesothelioma patients with available occupational history had occupational asbestos exposure. Restricting analysis to 48 patients with accessible medical records and using 67 occupational asbestosis patients for comparison, the epidemiology of mesothelioma in Hong Kong shares similarities with the literature: mean age of 63 years upon diagnosis, mean latency of 46 years, median survival of 9.5 months, male predominance, selective presentation among women, high prevalence among workers in ships and dockyards, predominantly epithelioid type, lower prevalence of asbestos bodies, and negative association with pleural plaques. Asbestos consumption in Hong Kong rose in the 1970s and peaked in early 1980s and late 1990s. Hong Kong may encounter an epidemic of mesothelioma in the 2010s if effective occupational asbestos control measures are not in place.

  20. Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression.

    Science.gov (United States)

    Cortez, Beatriz Araujo; Rezende-Teixeira, Paula; Redick, Sambra; Doxsey, Stephen; Machado-Santelli, Glaucia Maria

    2016-02-23

    Chrysotile, like other types of asbestos, has been associated with mesothelioma, lung cancer and asbestosis. However, the cellular abnormalities induced by these fibers involved in cancer development have not been elucidated yet. Previous works show that chrysotile fibers induce features of cancer cells, such as aneuploidy, multinucleation and multipolar mitosis. In the present study, normal and cancer derived human cell lines were treated with chrysotile and the cellular and molecular mechanisms related to generation of aneuploid cells was elucidated. The first alteration observed was cytokinesis regression, the main cause of multinucleated cells formation and centrosome amplification. The multinucleated cells formed after cytokinesis regression were able to progress through cell cycle and generated aneuploid cells after abnormal mitosis. To understand the process of cytokinesis regression, localization of cytokinetic proteins was investigated. It was observed mislocalization of Anillin, Aurora B, Septin 9 and Alix in the intercellular bridge, and no determination of secondary constriction and abscission sites. Fiber treatment also led to overexpression of genes related to cancer, cytokinesis and cell cycle. The results show that chrysotile fibers induce cellular and molecular alterations in normal and tumor cells that have been related to cancer initiation and progression, and that tetraploidization and aneuploid cell formation are striking events after fiber internalization, which could generate a favorable context to cancer development.

  1. [Granulomatous lung lesions after occupational exposure to glass fibers].

    Science.gov (United States)

    Klimczak, A; Langfort, R; Zych, J; Bestry, I; Rowińska-Zakrzewska, E

    2000-01-01

    39 years old man with granulomatous lesions in both lungs caused by occupational contact with glass fibers was described. He has been working as an bricklayer-plasterer for 18 years and was in contact with lime, cement, plaster, asbestos, dust of coal and wood and with glass fibers. For the last two years before admission in 1993 he has had frequent bronchial infections. On admission he was in good general condition, his spirometric examination and blood gases were within normal limits. On chest x-ray disseminated lesions were found. Those lesions were of the round shapes on chest CT. Many sputum cultures for tubercle bacilli were negative. ANA and ANCA were not found in the serum. ACE was within normal limits. No precipitins to environmental antigens were found. Cancer metastases were suspected and lung biopsy during videothoracoscopy was done. Many foreign body type granulomas were found throughout the specimen. The character of the lesions was not typical for tuberculosis, sarcoidosis, extrinsic allergic alveolitis, silicosis or asbestosis. There are some reports concerning the possibility of development of such lesions after the exposition to glass fibers. We suspect that case is an example of such pathology. His occupational exposition was stopped in 1993 and he was observed without treatment. During the 5 years of observation (up till 1998) he was in good health with stable chest x-ray picture and results of respiratory system function.

  2. Inhalational Lung Disease

    Directory of Open Access Journals (Sweden)

    S Kowsarian

    2010-01-01

    Full Text Available Inhalational lung diseases are among the most important occupational diseases. Pneumoconiosis refers to a group of lung diseases result from inhalation of usually inorganic dusts such as silicon dioxide, asbestos, coal, etc., and their deposition in the lungs. The resultant pulmonary disorders depend on the susceptibility of lungs; size, concentration, solubility and fibrogenic properties of the inhaled particles; and duration of exposure. Radiographic manifestations of pneumoconiosis become apparent several years after exposure to the particles. However, for certain types of dusts, e.g., silicone dioxide crystal and beryllium, heavy exposure within a short period can cause an acute disease. Pulmonary involvement in asbestosis is usually in the lower lobes. On the contrary, in silicosis and coal worker pneumoconiosis, the upper lobes are involved predominantly. For imaging evaluation of pneumoconiosis, high-resolution computed tomography (CT is superior to conventional chest x-ray. Magnetic resonance imaging (MRI and positron emission tomography (PET scan are helpful in those with suspected tumoral lesions. In this essay, we reviewed the imaging aspects of inhalational lung disease.

  3. Medical Surveillance for Former Workers

    Energy Technology Data Exchange (ETDEWEB)

    Tim Takaro

    2009-05-29

    The Former Hanford Worker Medical Monitoring Program, directed by the Occupational and Environmental Medicine Program at the University of Washington, served former production and other non-construction workers who were potentially exposed to workplace hazards while working for the USDOE or its contractors at Hanford. The USDOE Former Workers Program arose from Congressional action in the Defense Authorization of 1993 (Public Law 102). Section 3162 stated that, “The Secretary shall establish and carry out a program for the identification and ongoing medical evaluation of current and former Department of Energy employees who are subject to significant health risks as a result of exposure of such employees to hazardous or radioactive substances during such employment.” (This also covers former employees of USDOE contractors and subcontractors.) The key objective has been to provide these former workers with medical evaluations in order to determine whether workers have experienced significant risk due to workplace exposure to hazards. Exposures to asbestos, beryllium, and noise can produce specific medical conditions: asbestosis, berylliosis, and noise-induced hearing loss (NIHL). Each of these conditions can be identified by specific, non-invasive screening tests, which are widely available. Treatments are also available for individuals affected by these conditions. This project involved two phases. Phase I involved a needs and risk assessment, characterizing the nature and extent of workplace health hazards which may have increased the risk for long-term health effects. We categorized jobs and tasks by likelihood of exposures to specific workplace health hazards; and located and established contact with former Hanford workers. Phase II involved implementation of medical monitoring programs for former workers whose individual work history indicated significant risk for adverse health effects. We identified 118,000 former workers, employed from 1943 to 1997

  4. 1988至2014年青岛市某石棉厂石棉相关疾病发病情况%The incidence of asbestos-related diseases about on asbestos enterprises in Qingdao from 1988 to 2014

    Institute of Scientific and Technical Information of China (English)

    宋平平; 王艳; 孙建岭; 高燕; 刘娟; 陈艳霞

    2016-01-01

    目的 分析青岛市某石棉制品厂1988至2014年确诊的石棉相关疾病的发病状况和特点,为研究和制定石棉相关疾病防治措施及策略提供依据.方法 收集1988至2014年青岛某石棉制品厂确诊的石棉相关疾病资料,对全部资料进行录入、整理及汇总和进行统计分析.结果 在27年期间石棉相关疾病累计诊断625人,其中石棉肺617人,分期为Ⅰ期500人,Ⅱ期112人Ⅲ期5人;发病年龄(64.8±9.9)岁,工龄(24.5±7.4)年;石棉所致肺癌共12人,发病年龄(66.3±11.2)岁,工龄(29.2±7.8)年;石棉所致间皮瘤4人,发病年龄49-78(M=60)岁,工龄24-30(M=27)年;石棉肺病死率为38.74%,胸膜斑发生率为37.44%,肺结核发生率为5.19%,结论 青岛市某石棉制品厂石棉相关疾病发病率较高,以石棉肺为主,发病与接触石棉的工龄、车间石棉粉尘浓度、工种密切相关.石棉相关疾病仍是以后青岛市职业病防治的重点.%Objective It can provide statistics reference for the prevention and treatment by analysising the status and characteristics related to the asbestos disease of an asbestos products enterprises from 1988 to 2014.Methods We have collected the data concerning the case of asbestos-related disease between 1988 and 2014,then the data were arranged,collecteted and analyzed using statistical method.Results The total of patients is 625 (male:225,female:400).Diagnosis of asbestosis is 617 cases,Accordingly,stage Ⅰ is 500,stage Ⅱ is 112 and stage Ⅲ is 5.Average age of morbidity is 64.84±9.87 and working age is 24.45±7.40 years;The patients of lung cancer caused by asbestos are 12 people,and average age of morbidity is 66.25±11.20 years,and the working age is 29.18±7.77years;The patients of mesothelioma are 4 people,average age of morbidity is 49-78 (M=60)and working age is 27years.Asbestosis patients with complications of pleural plaque is 37.44%,complications of pulmonary tuberculosis is 5.19%.,and there are

  5. Asbestos-related diseases of the thorax; Asbestverursachte Veraenderungen am Thorax

    Energy Technology Data Exchange (ETDEWEB)

    Hieckel, H.G. [Evangelische Lungenklinik Berlin (Germany); Hering, K.G. [Knappschaftskrankenhaus Dortmund (Germany)

    2010-07-15

    Asbestos fibers can lead to pulmonary fibrosis, thickening of the pleura and malignancies. These pathologic changes are possible rather than determinate and depend on the type of asbestos fiber, length of exposure to fibers and individual factors. In Germany asbestos fibers were widely used until 1993. Worldwide, there is currently no general ban on the use of asbestos. The leading cause of asbestos-related diseases is occupational exposure. Due to a long latency period the appearance of such diseases may be delayed for more than 40 years so that the final number of cases has not yet been reached. Occupationally-derived asbestos-related diseases of the thorax are asbestosis, asbestos-related benign pleurisy and malignant pleural mesothelioma. Bronchial carcinoma can also be caused by asbestos exposure. For proof of occupational exposure, radiologists are required to report the presence of characteristic findings. The detection, in particular by chest X-ray and high resolution computed tomography (HRCT), requires high quality images and standardized evaluation. The standardized ILO classification and the semi-quantitative HRCT coding are medical findings on which statutory registration criteria are based. (orig.) [German] Asbestfasern koennen zu einer Lungenfibrose, zu Verdickungen der Pleura und zu Malignomen fuehren. Diese pathologischen Veraenderungen sind fakultativ und abhaengig von der Asbestart, der Dauer der Exposition und von individuellen Faktoren. Asbest fand bis 1993 in Deutschland breiten Einsatz. Weltweit besteht noch kein Verbot. Mehrheitlich sind asbestbedingte Erkrankungen Folgen beruflicher Expositionen. Bis zu ihrem Auftreten liegen lange Latenzzeiten bis ueber 40 Jahre, sodass das Maximum noch nicht erreicht ist. Asbestverursachte Berufserkrankungen am Thorax sind die Asbestose und asbestverursachte benigne Pleuraerkrankungen sowie das maligne Pleuramesotheliom. Bronchialkarzinome koennen asbestverursacht sein. Zur Beweisfuehrung wird von der

  6. Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoon Kyung [Department of Radiology, Gachon University Gil Medical Center, Incheon 21565 (Korea, Republic of); Kim, Jeung Sook [Department of Radiology, Dongguk University Ilsan Hospital, Goyang 10326 (Korea, Republic of); Lee, Kyung Won [Department of Radiology, Seoul National University Bundang Hospital, Seongnam 13620 (Korea, Republic of); Yi, Chin A [Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351 (Korea, Republic of); Koo, Jin Mo [Department of Radiology, Seoul National University College of Medicine, Seoul 03080 (Korea, Republic of); Jung, Soon-Hee [Department of Pathology, Yonsei University Wonju College of Medicine, Wonju 26426 (Korea, Republic of)

    2016-11-01

    To compare the multidetector CT (MDCT) features of malignant pleural mesothelioma (MPM) and metastatic pleural disease (MPD). The authors reviewed the MDCT images of 167 patients, 103 patients with MPM and 64 patients with MPD. All 167 cases were pathologically confirmed by sonography-guided needle biopsy of pleura, thoracoscopic pleural biopsy, or open thoracotomy. CT features were evaluated with respect to pleural effusion, pleural thickening, invasion of other organs, lung abnormality, lymphadenopathy, mediastinal shifting, thoracic volume decrease, asbestosis, and the presence of pleural plaque. Pleural thickening was the most common CT finding in MPM (96.1%) and MPD (93.8%). Circumferential pleural thickening (31.1% vs. 10.9%, odds ratio [OR] 3.670), thickening of fissural pleura (83.5% vs. 67.2%, OR 2.471), thickening of diaphragmatic pleura (90.3% vs. 73.4%, OR 3.364), pleural mass (38.8% vs. 23.4%, OR 2.074), pericardial involvement (56.3% vs. 20.3%, OR 5.056), and pleural plaque (66.0% vs. 21.9%, OR 6.939) were more frequently seen in MPM than in MPD. On the other hand, nodular pleural thickening (59.2% vs. 76.6%, OR 0.445), hilar lymph node metastasis (5.8% vs. 20.3%, OR 0.243), mediastinal lymph node metastasis (10.7% vs. 37.5%, OR 0.199), and hematogenous lung metastasis (9.7% vs. 29.2%, OR 0.261) were less frequent in MPM than in MPD. When we analyzed MPD from extrathoracic malignancy (EMPD) separately and compared them to MPM, circumferential pleural thickening, thickening of interlobar fissure, pericardial involvement and presence of pleural plaque were significant findings indicating MPM than EMPD. MPM had significantly lower occurrence of hematogenous lung metastasis, as compared with EMPD. Awareness of frequent and infrequent CT findings could aid in distinguishing MPM from MPD.

  7. Bilateral environmental and occupational health program with India.

    Science.gov (United States)

    Allred, Mike; Campolucci, Sharon; Falk, Henry; Ganguly, N K; Saiyed, H N; Shah, Bela

    2003-08-01

    In spite of considerable economic progress in recent years, India continues to face challenges dealing with poverty, unemployment, malnutrition, disease and disability. The governments of India and the United States have formed a collaborative effort to address outstanding issues in the fields of environmental and occupational health. The Joint Statement on Indo-U.S. Collaboration in Environmental and Occupational Health, which was approved by the Minister of the Indian Union of Health and Family Welfare and the Secretary of Health and Human Services of the United State in Geneva in May of 2002, formalizes the collaborative relationship and calls for the development of Implementation Guidelines. The Implementation Guidelines establish a Joint Working Group, which is responsible for identifying and implementing the collaborative projects. The collaborating organizations have identified three broad areas for collaboration: emergency preparedness and response; training, education, and technology transfer; and research. Within the three broad areas, the organizations have identified two subject areas for initiation: arsenicosis and asbestosis. Researchers and health officials in both India and the U.S. share interest in both research and interventions efforts in these subject areas. As many as 42 million people in the West Bengal area of India may be exposed to arsenic in drinking water at concentrations of health concern. Similarly, as many as 10 million industrial or mine workers in India may be exposed to asbestos or other dusts at concentrations of health concern. The first Joint Working Group meeting is scheduled for March 2003 in New Delhi and will consider these subject areas in developing collaborative projects. Other tasks being undertaken by the signatory agencies include expanding the relationship to include academic and nongovernmental organizations and obtaining funds for the various projects from governmental and nongovernmental sources.

  8. An Overview of the Health Hazards Due to Toxic Exposure in the Indian Work Environment

    Directory of Open Access Journals (Sweden)

    S. S. Ramaswamy

    1987-04-01

    Full Text Available Since independence, there has been a phenomenal growth in the chemical industry, the number of units rising from 98 in 1947 to 964 in 1953 and 4364 in 1976. With the national demands ever growing, this trend of growth in chemical industry will continue in future also. The chemical units handle numerous toxic chemicals such as asbestos, benzene, carbon disulphide, carcinogenic dye intermediates, lead, manganese, organophosphorus pesticides, phosgene, vinyl chloride etc.Being aware of the potential health hazards arising out of exposure to these toxic chemicals necessary safeguards against health hazards have been incorporated in the Factories Act 1948.With nearly 100,000 tonnes of asbestos, over 100,000 tonnes of benzene, and considerably large quantities of other toxic chemicals being handled in the country, understandably, the random studies and surveys by research agencies have revealed the incidence of definite        asbestosis (7 per cent, benzene intoxication in alkaloid extraction units ( 44.8 per cent, lead poisoning in storage battery units (10.6 per cent, carbon disulphide poisoning in viscose rayon units (20 per cent, mercury poisoning and intoxication in chloroalkali units (22.7 per cent, manganese poisoning in ferromanganese units (24 per cent, silicosis among slate pencil workers (54.7 per cent etc.Albeit such a condition, the cases documented in official reports are very few. Even the scattered studies by research institution in occupational health cannot be pooled to evolve a national picture, since, quite often there is no standardised approach in the studies undertaken by different institutions.After discussing the findings of studies on various toxic chemicals and substances, the paper enumerates the present deficiencies in the current studies and suggest steps for obtaining comprehensive information on health hazards.

  9. Pulmonary toxicity of carbon nanotubes and asbestos - similarities and differences.

    Science.gov (United States)

    Donaldson, Ken; Poland, Craig A; Murphy, Fiona A; MacFarlane, Marion; Chernova, Tatyana; Schinwald, Anja

    2013-12-01

    Carbon nanotubes are a valuable industrial product but there is potential for human pulmonary exposure during production and their fibrous shape raises the possibility that they may have effects like asbestos, which caused a worldwide pandemic of disease in the20th century that continues into present. CNT may exist as fibres or as more compact particles and the asbestos-type hazard only pertains to the fibrous forms of CNT. Exposure to asbestos causes asbestosis, bronchogenic carcinoma, mesothelioma, pleural fibrosis and pleural plaques indicating that both the lungs and the pleura are targets. The fibre pathogenicity paradigm was developed in the 1970s-80s and has a robust structure/toxicity relationship that enables the prediction of the pathogenicity of fibres depending on their length, thickness and biopersistence. Fibres that are sufficiently long and biopersistent and that deposit in the lungs can cause oxidative stress and inflammation. They may also translocate to the pleura where they can be retained depending on their length, and where they cause inflammation and oxidative stress in the pleural tissues. These pathobiological processes culminate in pathologic change - fibroplasia and neoplasia in the lungs and the pleura. There may also be direct genotoxic effects of fibres on epithelial cells and mesothelium, contributing to neoplasia. CNT show some of the properties of asbestos and other types of fibre in producing these types of effects and more research is needed. In terms of the molecular pathways involved in the interaction of long biopersistent fibres with target tissue the events leading to mesothelioma have been a particular area of interest. A variety of kinase pathways important in proliferation are activated by asbestos leading to pre-malignant states and investigations are under way to determine whether fibrous CNT also affects these molecular pathways. Current research suggests that fibrous CNT can elicit effects similar to asbestos but more

  10. Physical activity in people with asbestos related pleural disease and dust-related interstitial lung disease: An observational study.

    Science.gov (United States)

    Dale, Marita T; McKeough, Zoe J; Munoz, Phillip A; Corte, Peter; Bye, Peter T P; Alison, Jennifer A

    2015-11-01

    This study aimed to measure the levels of physical activity (PA) in people with dust-related pleural and interstitial lung diseases and to compare these levels of PA to a healthy population. There is limited data on PA in this patient population and no previous studies have compared PA in people with dust-related respiratory diseases to a healthy control group. Participants with a diagnosis of a dust-related respiratory disease including asbestosis and asbestos related pleural disease (ARPD) and a healthy age- and gender-matched population wore the SenseWear(®) Pro3 armband for 9 days. Six-minute walk distance, Medical Outcomes Study 36-item short-form health survey and the Hospital Anxiety and Depression Scale were also measured. Fifty participants were recruited and 46 completed the study; 22 with ARPD, 10 with dust-related interstitial lung disease (ILD) and 14 healthy age-matched participants. The mean (standard deviation) steps/day were 6097 (1939) steps/day for dust-related ILD, 9150 (3392) steps/day for ARPD and 10,630 (3465) steps/day for healthy participants. Compared with the healthy participants, dust-related ILD participants were significantly less active as measured by steps/day ((mean difference 4533 steps/day (95% confidence interval (CI): 1888-7178)) and energy expenditure, ((mean difference 512 calories (95% CI: 196-827)) and spent significantly less time engaging in moderate, vigorous or very vigorous activities (i.e. >3 metabolic equivalents; mean difference 1.2 hours/day (95% CI: 0.4-2.0)). There were no differences in levels of PA between healthy participants and those with ARPD. PA was reduced in people with dust-related ILD but not those with ARPD when compared with healthy age and gender-matched individuals.

  11. Asbestos-induced lung disease in small-scale clutch manufacturing workers

    Science.gov (United States)

    Gothi, Dipti; Gahlot, Tanushree; Sah, Ram B.; Saxena, Mayank; Ojha, U. C.; Verma, Anand K.; Spalgais, Sonam

    2016-01-01

    Background: The crocidolite variety of asbestos is banned. However, chrysotile, which is not prohibited, is still used in developing countries in making products such as clutch plate. Fourteen workers from a small-scale clutch plate-manufacturing factory were analyzed for asbestos-induced lung disease as one of their colleagues had expired due to asbestosis. Aims: This study was conducted to evaluate the awareness of workers, the prevalence and type of asbestos-induced lung disease, and the sensitivity and specificity of diffusion test. Materials and Methods: History, examination, chest radiograph, spirometry with diffusion, and high resolution computed tomography (HRCT) thorax was performed in all the workers. The diagnosis of asbestos-induced lung disease was suspected on the basis of HRCT. This was subsequently confirmed on transbronchial lung biopsy (TBLB). Results: None of the workers had detailed information about asbestos and its ill effects. Eleven out of 14 (71.42%) workers had asbestos-induced lung disease. All 11 had small airway disease (SAD). Three had SAD alone, 6 had additional interstitial lung disease (ILD), and 2 patients had additional ILD and chronic obstructive pulmonary disease. Sensitivity and specificity of residual volume (RV) or total lung capacity (TLC) for detecting SAD was 90% and 100%, respectively, and that of diffusion capacity of lung for carbon monoxide (DLCO) for detecting ILD was 100%. Conclusion: The awareness about asbestos in small-scale clutch-plate manufacturing industry is poor. The usage of chrysotile should be strictly regulated as morbidity and mortality is high. DLCO and RV/TLC are sensitive and specific in detecting nonmalignant asbestos induced lung disease.

  12. Predicting the mortality from asbestos-related diseases based on the amount of asbestos used and the effects of slate buildings in Korea.

    Science.gov (United States)

    Kim, Su-Young; Kim, Young-Chan; Kim, Yongku; Hong, Won-Hwa

    2016-01-15

    Asbestos has been used since ancient times, owing to its heat-resistant, rot-proof, and insulating qualities, and its usage rapidly increased after the industrial revolution. In Korea, all slates were previously manufactured in a mixture of about 90% cement and 10% chrysotile (white asbestos). This study used a Generalized Poisson regression (GPR) model after creating databases of the mortality from asbestos-related diseases and of the amount of asbestos used in Korea as a means to predict the future mortality of asbestos-related diseases and mesothelioma in Korea. Moreover, to predict the future mortality according to the effects of slate buildings, a comparative analysis based on the result of the GPR model was conducted after creating databases of the amount of asbestos used in Korea and of the amount of asbestos used in making slates. We predicted the mortality from asbestos-related diseases by year, from 2014 to 2036, according to the amount of asbestos used. As a result, it was predicted that a total of 1942 people (maximum, 3476) will die by 2036. Moreover, based on the comparative analysis according to the influence index, it was predicted that a maximum of 555 people will die from asbestos-related diseases by 2031 as a result of the effects of asbestos-containing slate buildings, and the mortality was predicted to peak in 2021, with 53 cases. Although mesothelioma and pulmonary asbestosis were considered as asbestos-related diseases, these are not the only two diseases caused by asbestos. However the results of this study are highly important and relevant, as, for the first time in Korea, the future mortality from asbestos-related diseases was predicted. These findings are expected to contribute greatly to the Korean government's policies related to the compensation for asbestos victims.

  13. 国产X射线衍射仪在婴儿爽身粉石棉检测的应用%Application of Domestic X-Ray Diffraction Instrument in Detecting Asbestos of Baby Toilet Powder

    Institute of Scientific and Technical Information of China (English)

    由健; 刘成雁

    2013-01-01

    化妆品级滑石粉是各种润肤粉、美容粉、婴儿爽身粉等化妆品中常用辅料.在生产滑石粉的矿物中常常含有伴生矿物石棉.石棉纤维对人体危害很大,长期吸入能引起石棉肺、肺癌、胸膜间皮瘤等疾病.采用国产X射线衍射(XRD)-偏光显微镜(PLM)法检测婴儿爽身粉中石棉.该方法可以有效检测婴儿爽身粉中有害矿物石棉.克服单独使用某一种检测手段的不足及片面性,实现快速准确的鉴定粉类化妆品中微量石棉.%Talc powder for cosmetic is the most useful excipient in moisturizing powder,after shave powder and baby powder.There is some asbestos in the production of talc powder mineral.Asbestos fiber does great harm to human body,which can cause disease such as lung cancer,pleural mesothelioma and asbestosis for long-term inhalation.The combined application of domestic X-ray diffraction (XRD) and polarizing microscope (PLM) is rapid and accurate,which can effectively detect the asbestos minerals in baby powder and conquer the lack of one-side in single detection.

  14. Enfermedad pulmonar por amianto en trabajadores de acería

    Directory of Open Access Journals (Sweden)

    Rita Zurbriggen

    2013-06-01

    Full Text Available Las enfermedades relacionadas al amianto se producen por la inhalación de fibras de asbestos en su variedad crisotilo o amianto blanco. A pesar de que en la Argentina la prohibición data del año 2003, existen numerosas industrias donde se sigue trabajando con este mineral, entre ellas las metalúrgicas y acerías. Actualmente se conoce la alta patogenicidad de este material, por lo que en muchos países existen programas de seguimiento de los trabajadores expuestos. Se describen las características generales y manifestaciones clínicas pulmonares de 27 pacientes que trabajaron en una gran acería de América del Sur. El diagnóstico de amiantopatías se realizó mediante historia clínica laboral, antecedente de exposición al amianto, estudios complementarios de función pulmonar e imágenes del tórax. Se analizaron la fuente de exposición (laboral, doméstica y ambiental, tiempo de exposición y período de latencia en los pacientes de los cuales se detectó enfermedad relacionada. Los antecedentes de tabaquismo fueron tenidos en cuenta para el análisis. En 22 pacientes se presentaron patologías benignas (81.4%, 16 de ellos tenían lesiones exclusivamente pleurales y otros 6 asbestosis. Las patologías malignas se presentaron en 5 pacientes (18.5%, en 4 fueron mesoteliomas y en uno carcinoma pulmonar. El problema de la exposición al amianto tiene vigencia actual. De ahí la necesidad de un programa de vigilancia en trabajadores expuestos al amianto actualmente o en el pasado, para detectar, notificar, registrar e investigar las características de estas patologías.

  15. CT characteristics of pleural plaques related to occupational or environmental asbestos exposure from South Korean asbestos mines

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoo Kyung [Dept. of Radiology, School of Medicine, Ewha Womans University, Seoul (Korea, Republic of); Myong, Jun Pyo [Dept. of Occupational and Environmental Medicine, Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of); Lee, Jeong Kyong [Dept. of Radiology, Dongguk University Ilsan Hospital, Goyang (Korea, Republic of); Kim, Yoon Kyung [Dept. of Radiology, Gachon University Gil Medical Center, Incheon (Korea, Republic of); Jung, Soon Hee [Dept. of Pathology, Yonsei University Wonju College of Medicine, Wonju (Korea, Republic of)

    2015-10-15

    This study evaluated the CT characteristics of pleural plaques in asbestos-exposed individuals and compared occupational versus environmental exposure groups. This study enrolled 181 subjects with occupational exposure and 98 with environmental exposure from chrysotile asbestos mines, who had pleural plaques confirmed by a chest CT. The CT scans were analyzed for morphological characteristics, the number and distribution of pleural plaques and combined pulmonary fibrosis. Furthermore, the CT findings were compared between the occupational and environmental exposure groups. Concerning the 279 subjects, the pleural plaques were single in 2.2% and unilateral in 3.6%, and showed variable widths (range, 1-20 mm; mean, 5.4 ± 2.7 mm) and lengths (5-310 mm; 72.6 ± 54.8 mm). The chest wall was the most commonly involved (98.6%), with an upper predominance on the ventral side (upper, 77.8% vs. lower, 55.9%, p < 0.001) and a lower predominance on the dorsal side (upper, 74.9% vs. lower, 91.8%, p = 0.02). Diaphragmatic involvement (78.1%) showed a right-side predominance (right, 73.8% vs. left, 55.6%, p < 0.001), whereas mediastinal plaques (42.7%) were more frequent on the left (right, 17.6% vs. left, 39.4%, p < 0.001). The extent and maximum length of plaques, and presence and severity of combined asbestosis, were significantly higher in the occupational exposure group (p < 0.05). Pleural plaques in asbestos-exposed individuals are variable in number and size; and show a predominant distribution in the upper ventral and lower dorsal chest walls, right diaphragm, and left mediastinum. Asbestos mine workers have a higher extent of plaques and pulmonary fibrosis versus environmentally exposed individuals.

  16. Multidetector CT findings and differential diagnoses of malignant pleural mesothelioma and metastatic pleural diseases in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoon Kyung [Dept. of Radiology, Gachon University Gil Medical Center, Incheon (Korea, Republic of); Kim, Jeung Sook [Dept. of Radiology, Dongguk University Ilsan Hospital, Goyang (Korea, Republic of); Lee, Kyung Won [Dept. of Radiology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Yi, Chin A [Dept. of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Koo, Jin Mo [Dept. of Radiology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Jung, Soon Hee [Dept. of Pathology, Yonsei University Wonju College of Medicine, Wonju (Korea, Republic of)

    2016-07-15

    To compare the multidetector CT (MDCT) features of malignant pleural mesothelioma (MPM) and metastatic pleural disease (MPD). The authors reviewed the MDCT images of 167 patients, 103 patients with MPM and 64 patients with MPD. All 167 cases were pathologically confirmed by sonography-guided needle biopsy of pleura, thoracoscopic pleural biopsy, or open thoracotomy. CT features were evaluated with respect to pleural effusion, pleural thickening, invasion of other organs, lung abnormality, lymphadenopathy, mediastinal shifting, thoracic volume decrease, asbestosis, and the presence of pleural plaque. Pleural thickening was the most common CT finding in MPM (96.1%) and MPD (93.8%). Circumferential pleural thickening (31.1% vs. 10.9%, odds ratio [OR] 3.670), thickening of fissural pleura (83.5% vs. 67.2%, OR 2.471), thickening of diaphragmatic pleura (90.3% vs. 73.4%, OR 3.364), pleural mass (38.8% vs. 23.4%, OR 2.074), pericardial involvement (56.3% vs. 20.3%, OR 5.056), and pleural plaque (66.0% vs. 21.9%, OR 6.939) were more frequently seen in MPM than in MPD. On the other hand, nodular pleural thickening (59.2% vs. 76.6%, OR 0.445), hilar lymph node metastasis (5.8% vs. 20.3%, OR 0.243), mediastinal lymph node metastasis (10.7% vs. 37.5%, OR 0.199), and hematogenous lung metastasis (9.7% vs. 29.2%, OR 0.261) were less frequent in MPM than in MPD. When we analyzed MPD from extrathoracic malignancy (EMPD) separately and compared them to MPM, circumferential pleural thickening, thickening of interlobar fissure, pericardial involvement and presence of pleural plaque were significant findings indicating MPM than EMPD. MPM had significantly lower occurrence of hematogenous lung metastasis, as compared with EMPD. Awareness of frequent and infrequent CT findings could aid in distinguishing MPM from MPD.

  17. Siderophores, the answer for micro to nanosized asbestos fibre related health hazard

    Science.gov (United States)

    Bhattacharya, Shabori; Ledwani, Lalita; John, P. J.

    2016-04-01

    Recent studies on the potential toxicity of High Aspect Ratio Nanoparticles (HARN) has yet once again reinforced the health hazard imposed by asbestos fibres ranging from nano to micro size. Asbestos a naturally occurring fibrous mineral declared a Group I definite carcinogen by IARC (International Agency for Research on Cancer), a unit of WHO in the year 1987, has been extensively used since World War II to the near past for various commercial products. According to the most recent World Health Organization (WHO) estimates, asbestos-related diseases, resulting from exposure at workplace claims more than 107000 lives every year worldwide. The various types of toxic effects induced by asbestos in humans include - i) inflammation and fibrogenesis of lung, ii) mesothelioma iii) asbestosis and iv) bronchogenic carcinoma. The stability of asbestos in natural environment and its biological aggressiveness is related to their fibrous structure and dimensions. The actual risk associated with the exposure to nanosized asbestos, which is still unknown and escapes most regulations worldwide, has been shown in various toxicity assessment studies conducted on various animal models.In an effort to reduce the size of asbestos and therby its toxicity by limiting its biopersistence, oxalic acid treatment of asbestos coupled to power ultrasound treatment was carried out. The nanosized particles formed were still found to retain their hazardous effect. Similar were the results obtained on strong acid treatment of asbestos as well. A probable solution to the asbestos toxicity problem therefore envisaged was bioremediation. This involved the secretion of iron chelating molecules termed siderophores by microbes, which are of significance due to their ability to form very stable and soluble complexes with iron. Iron in asbestos composition is a major factor responsible for its carcinogenicity, removal or extraction of which would prove to be an effective answer to the worldwide problem

  18. [Wonder matter and assassin. The perception of the asbestos danger as a mirror of the time 1930-1990].

    Science.gov (United States)

    Janssen, J H M

    2005-01-01

    In the seventies and eighties of the twentieth century the ideas of the dangers concerning the use of asbestos changed dramatically. The mineral, which had, more than half a century before been introduced in the Netherlands as a miraculous mineral, was completely banned from use. Asbestos became known as a 'silent killer' and 'the blue sand of death', and as a symbol of the hidden hazards of a deteriorating environment caused by unscrupulous companies and indolent authorities. Asbestos seems to fit perfectly into the ubiquitous hazards which Ulrich Beck defines in his concept of the 'risk society' as the dangerous side effects of industrial production. Yet the perception of the risk associated with asbestos depended more on socio-cultural characteristics than on scientifically risk assessments. In the first half of the twentieth century the use of asbestos was limited and therefore did not cause any concern. Economic crisis and war silenced the first alarming signals of asbestos related disease from foreign experts and a handful of Dutch physicians. The asbestos workers themselves were held responsible for their own health and safety. In the 1951 asbestosis became recognised as an industrial disease. Preventive measures with regard to the industrial use of asbestos were prescribed by law. Workers shared the responsibilities for a safe use with employers and authorities. However, during this period, all the attention was directed towards economic growth. Supervision by the labour inspection was scarce and workers and employers were not very interested in upholding the safety measures. Among asbestos workers the use of protective clothes and dust masks was generally seen as unmanly. In the sixties the foreign literature on the connection between the exposure to asbestos and the occurrence of lung cancer and mesothelioma became known among Dutch specialists. The results of these studies were confirmed by research among Dutch insulation workers. At the same time the

  19. Talcose entre artesãos em pedra-sabão em uma localidade rural do Município de Ouro Preto, Minas Gerais, Brasil Talc pneumoconiosis among soapstone handicraft workers in a rural area of Ouro Preto, Minas Gerais, Brazil

    Directory of Open Access Journals (Sweden)

    Olívia Maria de Paula Alves Bezerra

    2003-12-01

    12 adult workers. Chest x-rays showed evidence of small lung opacities in 5 workers, and in 11 there was suspicion of the same opacities. One worker showed a plaque-shaped pleural thickening. Seven workers showed abnormal spirometry. The soapstone dust composition showed breathable asbestos fibers from the amphibole group (tremolite-actinolite. The results suggest talc asbestosis occurrence among soapstone handicraft workers.

  20. CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.

    Science.gov (United States)

    Schneider, Joachim; Bernges, Ulrike

    2009-01-01

    CYP1A1 and CYP1B1 are involved in the metabolism of carcinogens. The effect of CYP1A1 and CYP1B1 polymorphisms as genetic modifiers of risk was investigated in individuals with asbestos, silica dust or ionizing radiation-induced occupational tumours compared to exposed non-cancer subjects suffering from pneumoconiosis, particularly in relation to tobacco smoking. CYP1A1 T6235C, CYP1A1 A4889G and CYP1B1 codon 432 polymorphisms were determined by real-time PCR analysis in patients with asbestos-related lung cancer (n=39), patients with diffuse malignant mesotheliomas (n=19), lung cancer in silicosis patients (n=7), uranium miners with lung cancer (UMLC) (n=40), patients with asbestosis (n=181), and silicosis patients (n=204). The results were compared to those from a healthy unexposed control group (n=50) not exposed to carcinogenic (or fibrogenic) agents in the workplace. An additional healthy control group (n=134) comprised smokers and ex-smokers. Allele frequencies were within the range described for Caucasians. Multivariate analysis revealed that patients with occupational diseases with the susceptible CYP1A1 T6235C genotype had a calculated risk ranging from OR=0.5 (95% CI 0.18-1.36) for UMLC to OR=1.23 (95% CI 0.39-4.05) for uranium miners with silicosis. The risk for patients with the susceptible CYP1A1 A4889G allele was calculated as being between OR=0.39 (95% CI 0.10-1.54) for mesothelioma patients and OR=1.54 (95% CI 0.49-4.89) for UMLC. CYP1B1 Val432Leu polymorphisms were associated with a risk of OR=0.56 (95% CI 0.2-1.55) for UMLC and OR=1.52 (95% CI 0.68-3.39) for asbestos-exposed lung cancer patients. By analyzing the interaction between tobacco smoking, type of exposure to carcinogens and the genotypes, it was determined that smoking and the presence of the susceptible genotypes did not have a combined effect. In this pilot study, the analyzed polymorphism had no consistent modifying effect on pneumoconiosis or occupationally related tumours.

  1. The Strength of Disease: Molecular Bonds Between Asbestos and Human Cells

    Science.gov (United States)

    Taylor, E. S.; Lower, S. K.; Wylie, A. G.; Mossman, B. T.

    2008-12-01

    Occupational exposure to asbestos has been linked to the development of life-threatening cancers (i.e., mesothelioma) and diseases (i.e., asbestosis), which can sometimes take decades to appear after initial exposure. There is increasing evidence that environmental exposure to asbestos is a significant public health concern in some regions of the United States, and this type of asbestos contamination could lead to an epidemic of mesothelioma for at least the next two decades. Although mines and regions nearby should be safer with stricter protocols for processing asbestos, the long latent period for asbestos-related diseases makes understanding them an ever-present concern. In addition to the many epidemiological studies, laboratory in vitro and in vivo studies on the biochemical effect of asbestos show that the most trusted predictor for disease is the dosage of longer, thinner chrysotile and amphibole asbestos fibers. However, many scientists agree that incorporating the many physical and chemical properties of the mineral fibers is needed to properly assess their influence. The study of asbestos-related disease is essentially a multidisciplinary task, requiring knowledge from medicine, biochemistry and mineralogy. To bridge the gap between these disciplines, attention needs to be placed on the molecular communication between the asbestos fibers and the biological environments in which they can be deposited. Our work focused on determining the surface chemical response of riebeckite and crocidolite-its asbestiform counterpart-to changes in salinity and pH. As expected, studies on the mineral surface charge using atomic force microscopy (AFM) yielded a slight dependence on pH, as measured by the adhesion force acting on the probe, but not on ionic strength, except at near zero salt concentration. A transition was found for the surface charge of crocidolite above pH 7, where forces at the mineral surface increased. In contrast, the surface charge on riebeckite was

  2. Review of Control Laws and Detection Methods for Asbestos%石棉控制法规及其检测方法

    Institute of Scientific and Technical Information of China (English)

    鲍俊; 王全林

    2011-01-01

    介绍了石棉的特性、危害,以及在建筑、纺织、设备制造业和国防工业等方面的应用情况.讨论了能够导致石棉肺、恶性间皮瘤、肺癌、支气管癌等恶性疾病的石棉纤维形态及进入人体的途径.对世界卫生组织、国际劳工组织、联合国环境规划署、联合国粮食及农业组织和世界贸易组织,以及美国、欧盟、日本、中国等40多个国家关于石棉控制法规的实施历程及现状进行了分析;同时对空气、饮用水、建筑材料和制品等实际样品中石棉的检测方法及标准化研究动态进行了评述.引用标准及学术文献91篇.%The characteristics of asbestos and its applications in the building, textile, equipment manufacturing and national defense industries are introduced in this paper. The shape and size of asbestos fiber which result in asbestosis, malignant mesothelioma, lung cancer and bronchial tube cancer, and the pathways into the human body are discussed. The control laws for asbestos around the world, such as the World Health Organization (WHO) , the International Labor Organization (ILO), the United Nations Environment Programme (UNEP), the Food and Agriculture Organization (FAO), the World Trade Organization (WTO), and more than 40 countries, are also discussed. Developments of detection methods of asbestos in the air, drinking water and building materials are reviewed using 91 publications as reference material. This information is valuable for environmental protection from asbestos.

  3. Registro de enfermedades respiratorias de origen laboral en Navarra Registry of occupational respiratory diseases in Navarre

    Directory of Open Access Journals (Sweden)

    K. Abú Shams

    2005-01-01

    Full Text Available Fundamento. Con objeto de analizar la incidencia y características de la patología respiratoria ocupacional en Navarra, se implantó en enero de 2002 el Registro de Enfermedades Respiratorias de Origen Laboral. Métodos. Los casos notificados por los médicos colaboradores durante los años 2002, 2003 y 2004, se introdujeron en una base de datos diseñada para su análisis posterior, que constaba de distintas variables: sexo, edad, tabaco, servicio y médico declarante, diagnóstico, profesión y agente causal. Resultados. Se notificaron 125 casos. 97 varones (77,6% y 28 mujeres (22,4%. La media de edad fue 55,4 años. Ochenta y ocho pacientes no fumaban (70,4% y 37 eran fumadores (29,6%. Neumología declaró 84 casos (67,2% y Alergología 41 (32,8%. Los diagnósticos fueron: 50 casos de asma bronquial (40%, 31 de enfermedad pleural benigna (24,8%, 8 alveolitis alérgica extrínseca (6,4%, 8 mesotelioma (6,4%, 7 cáncer broncopulmonar (5,6%, 5 inhalaciones agudas (4%, 3 asbestosis (2,4%, 2 rinitis (1,6%, 1 RADS (0,8% y 1 EPOC (0,8%. Las profesiones más declaradas: 13 pintura/barnizado (10,4%, 12 hilado de ovillos de amianto (9,6% y 8 panadería/pastelería (6,4%. Como agentes causales principales: 49 casos de asbesto (39,2%, 15 isocianatos (12% y 8 sílice (6,4%. Conclusiones. La patología más frecuente fue el asma bronquial, seguida de la enfermedad pleural benigna. La profesión más notificada era pintura/barnizado y en segundo lugar hilado de ovillos. El asbesto fue la primera sustancia implicada seguida de los isocianatos. La mayoría de pacientes eran varones y no fumadores. El Servicio de Neumología del Hospital Virgen del Camino notificó el mayor número de casos. El análisis de contraste de proporciones mostró cierta tendencia a la significación en rinitis, asma bronquial y asbestosis.Background. In January 2002 an occupational respiratory diseases record was established in Navarre so that the number and characteristics of the

  4. Opiniones y expectativas de pacientes con enfermedades relacionadas con la exposición al amianto Opinions and expectations of patients with health problems associated to asbestos exposure

    Directory of Open Access Journals (Sweden)

    M.A. Prieto

    2011-04-01

    Full Text Available Fundamento. La prevalencia de enfermedades relacionadas con la exposición al amianto requiere el desarrollo de programas de vigilancia y protocolos de atención sanitaria específicas. El objetivo del estudio es conocer las opiniones y expectativas de los ex trabajadores de una fábrica de uralita, con el fin de adecuar el proceso asistencial a las necesidades de la población afectada, así como conocer la actividad de la asociación que les representa. Métodos. Estudio cualitativo desarrollado con grupos focales con extrabajadores de una fábrica de uralita, miembros de la asociación AVIDA (Sevilla. Grabación y trascripción de las entrevistas. Análisis de discurso, con ayuda del programa Nudist Vivo 1.0. Resultados. Todas las personas entrevistadas presentan problemas de salud, entre ellos asbestosis, cáncer de pulmón y mesotelioma. A través de la asociación, están en un proceso continuado de negociación con la administración pública para mejorar la atención sanitaria, lograr el reconocimiento como enfermedad laboral y el pago de indemnizaciones. Señalan como mayor problema del proceso asistencial actual la falta de seguimiento y continuidad en la atención. Valoran positivamente la creación de unidades de atención específicas, el trato humano recibido y la calidad de los instrumentos técnicos en el Sistema de Salud Público. En cambio, critican las dificultades de un diagnóstico acertado, la falta de continuidad asistencial, así como las dificultades burocráticas y la escasez de atención sanitaria específica a familiares afectados. Como expectativa de futuro, resaltan su interés en seguir participando en la elaboración de programas y protocolos. Conclusiones. El estudio confirma el carácter multifactorial de las enfermedades relacionadas con la exposición al amianto, así como la relevancia de conocer las necesidades y demandas de la población afectada para mejorar la atención sanitaria espec

  5. Asbestos related diseases from environmental exposure to crocidolite in Da-yao, China. I. Review of exposure and epidemiological data

    Science.gov (United States)

    Luo, S; Liu, X; Mu, S; Tsai, S; Wen, C; Wong, O.

    2003-01-01

    Background: Scattered patches of crocidolite, one form of asbestos, were found in the surface soil in the rural county of Da-yao in southwestern China. In 1983, researchers from the West China University of Medical Sciences (WCUMS) discovered that residents of two villages in Da-yao had hyperendemic pleural plaques and excessive numbers of pleural mesotheliomas. Aims: To review and summarise epidemiological studies, along with other relevant data, and to discuss the potential contribution to environmental risk assessment. Methods: This report is based on a review of several clinical/epidemiological studies conducted by WCUMS researchers since 1984, which included one cross sectional medical examination survey, one clinical/pathological analysis of 46 cases of mesothelioma, and three retrospective cohort mortality studies. Additional information acquired from reviewing original data first hand during a personal visit along with an interview of medical specialists from Da-yao County Hospital was also incorporated. Results: The prevalence of pleural plaque was 20% among peasants in Da-yao over 40 years of age in the cross sectional survey. The average number of mesothelioma cases was 6.6 per year in the 1984–95 period and 22 per year in the 1996–99 period, in a population of 68 000. For those mesothelioma cases that were histology confirmed, there were 3.8 cases/year in the first period and 9 cases/year in the second. Of the 2175 peasants in this survey, 16 had asbestosis. Lung cancer deaths were significantly increased in all three cohort studies. The annual mortality rate for mesothelioma was 85 per million, 178 per million, and 365 per million for the three cohort studies, respectively. The higher exposed peasants had a fivefold increased mesothelioma mortality compared to their lower exposed counterparts. There were no cases of mesothelioma in the comparison groups where no crocidolite was known to exist in the environment. In the third cohort study, almost

  6. Occupational Health Survey and Evaluation on Machine Spinning Asbestos in Yuyao%余姚市机纺石棉企业职业卫生现状调查与评价

    Institute of Scientific and Technical Information of China (English)

    苗超; 邵迪初; 胡向前; 叶虹

    2011-01-01

    [Objective] To understand the occupational health status and the impact on the health of workers in machine spinning asbestos, and to provide scientific basis for prevention and control of relative occupational diseases. [ Methods ] A total of 8 enterprises were investigated. The occupational health survey included detection and evaluation of asbestos dust concentrations, as well as occupational health inspection of 183 workers exposed to asbestos. [ Results ] The asbestos dust concentrations were higher than the national standard except 2 points qualified in 25 monitoring points. 3 workers were diagnosed as suspected asbestosis, 9 were observed objects and 37 were abnormal lung markings among the 183 workers. Each selected enterprise installed a mechanical ventilation/dust removal system and 2 to 4 spray devices. Each worker received two sets of working clothes and a dust mask per month. [ Conclusion ] Occupational hazards and severe health effects are found in machine spinning asbestos industry. Current personal protective equipment and protection facilities are imperfect. Health supervision of asbestos spinning enterprises should be strengthened, in order to improve the working environment and protect workers' occupational health in future.%[目的]了解余姚市机纺石棉企业作业场所职业卫生现状及该作业环境对作业工人健康的影响,为机纺石棉企业职业病防制提供科学依据.[方法]对余姚市8家机纺石棉企业进行职业卫生现状调查、石棉尘浓度检测和评价、183名作业工人职业健康检查.[结果]石棉尘浓度超标、25个监测点仅2点合格;183名作业工人中检出3名疑似石棉肺患者,9名观察对象及37名肺纹理异常者;每一企业设一套机械通风除尘装置及2~4个水雾喷淋装置,企业为每名工人发两套工作服和每月一副防尘口罩.[结论]机纺石棉企业职业危害和对工人健康影响是严重的,防护设施和个人防护用品