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Sample records for asa cssa sssa

  1. CSSA Spring Festival Gala 2004

    OpenAIRE

    CSSA, UK; CSSA, Cambridge; Yan, Xiaoxiao

    2004-01-01

    This is a 1 hour 37 minutes film recording exacts of Chinese Spring Festival Gala held in Corn Exchange Theatre in Cambridge on 16th January 2004. The occasion organiser was CSSA and audience were about 1000 people coming from all over UK in that evening.

  2. ASA branding

    OpenAIRE

    Kirkeby, Kennie; Jakobsen, Christian Yttergren; Birch, Frederik; Dalman, Newsha

    2014-01-01

    This thesis examines the company ASA Trading and how ASA, through branding, have used CSR and social entrepreneurship as a part of their branding. In order to illuminate these subjects, the thesis is based upon theory about branding, CSR, Story Telling and social entrepreneurship. In addition, the thesis uses a qualitative empirical data from interview with CEO of ASA Trading Julian Amery, and a rapport from CSE Roskilde University, 2008. This thesis discusses and analyses ASA’s us...

  3. Soil Science Education: Philosophy and Perspectives. SSSA Special Publication Number 37.

    Science.gov (United States)

    Baveye, Philippe, Ed.; And Others

    Soil science provides the educational framework to integrate components of earth science systems, to understand the causes and consequences of spatial variability, and view dynamic processes impacting ecosystems in a holistic perspective. This book, a special publication of the Soil Science Society of America (SSSA), identifies and analyzes…

  4. ASA education outreach

    Science.gov (United States)

    Hansen, Uwe J.; Everbach, E. Carr

    2003-04-01

    A number of very successful Hands-on demo sessions for high school students have been a part of regular ASA meetings for some time. In addition, the Education Committee has organized a series of teacher workshops. These workshops are designed to give high school teachers relatively sophisticated tools to enhance their laboratory content. Workshops for teachers in the elementary grades prepare teachers to use music as a vehicle to introduce additional science concepts. Content and methods associated with both workshops will be discussed. Cyberspace outreach by the ASA was accelerated by the establishment of a Home Page Committee, and more recently by the On-Line Education committee, which is creating an educational website. The website provides a fun way for users to access information including acoustics information, history, demos, and links to the Technical Committee's webpages. The ASA has joined other AIP member societies in developing additional mechanisms, including road shows and nightly news spots.

  5. Verdsettelse av Statoil ASA

    OpenAIRE

    Drangsholt, Bjørn Harald

    2011-01-01

    I løpet av denne oppgaven vil jeg utføre en fundamental verdsettelse av Statoil ASA basert på offentlig tilgjengelig informasjon. Med utgangspunkt i en strategisk analyse og en regnskapsanalyse ønsker jeg å finne verdien av Statoil-aksjen. Oppgaven innledes med en kort presentasjon av Statoil ASA, der det gis et innblikk i historie, foretningsområde og organisasjonsstruktur. Deretter følger en metodedel hvor jeg gir en rask innføring i verdsettelsesteori, samt gir en begrunnelse for mitt ...

  6. Verdsetting av Norsk Hydro ASA

    OpenAIRE

    Holmgren, Truls Ekhorn

    2014-01-01

    I denne oppgaven vil jeg finne ut om Norsk Hydro ASAs egenkapitalverdi gjenspeiles i aksjekursen som vi finner på Oslo Børs. Problemstillingen blir da som følger: "Hva er egenkapitalverdien til Norsk Hydro ASA?" Oppgaven begynner med en presentasjon av Norsk Hydro ASA og dets virke. Etterfulgt av en framlegging av aktuell teori innenfor verdsetting. Videre følger en vurdering av selskapets strategiske posisjon. Til den strategiske analysen benyttes rammeverkene Porters Five Forces og PE...

  7. ASA24-Kids-2014 and ASA24-Kids-2012

    Science.gov (United States)

    >ASA24-Kids-2014 was released in February 2014 and researchers can still register new studies in this version of the ASA24® system. A mobile accessible version is in development and is expected to be open to new studies later in 2016.

  8. Valuation of Norwegian Air Shuttle ASA

    OpenAIRE

    Nordbø, Christer; Raza, Jabbar

    2016-01-01

    The purpose of this thesis is to do a valuation on Norwegian Air Shuttle ASA, and based upon this objective we have formulated the following problem statement: “What is the fair value of Norwegian Air Shuttle ASA as per 31.03.2016?” The purpose of this valuation is to evaluate if the stock price is either over or under priced. Based on the findings in this thesis, we estimated the stock price of Norwegian Air Shuttle ASA to be NOK 283,1. On 31.03.2016 the stock price of Norwegian Air Shuttle ...

  9. ASA24-Australian Version (Under Development)

    Science.gov (United States)

    In collaboration with the National Cancer Institute (NCI), a consortium of Australian Researchers is adapting the ASA24 system to the Australian context to account for variations in food consumed, portion sizes, and nutrient composition.

  10. Adaptive simulated annealing (ASA): Lessons learned

    OpenAIRE

    Ingber, L.

    2000-01-01

    Adaptive simulated annealing (ASA) is a global optimization algorithm based on an associated proof that the parameter space can be sampled much more efficiently than by using other previous simulated annealing algorithms. The author's ASA code has been publicly available for over two years. During this time the author has volunteered to help people via e-mail, and the feedback obtained has been used to further develop the code. Some lessons learned, in particular some which are relevant to ot...

  11. 5-ASA Suppositories in Hemorrhoidal Disease

    Directory of Open Access Journals (Sweden)

    P Gionchetti

    1992-01-01

    Full Text Available Forty patients with active hemorrhoidal disease were entered into this double-blind trial, 20 of whom were randomized to treatment with 5-aminosalicylic acid (5-ASA (500 mg suppositories. Clinical and sigmoidoscopic assessment was carried out before the start of the trial and after two weeks of treatment. At the end of the study, 5-ASA suppositories showed results superior to those of placebo for all parameters evaluated (P<0.01. There were no adverse events reported related to the use of suppositories. 5-ASA suppositories are a valid therapeutic approach for hemorrhoidal disease as it reduces the intensity of all symptoms and significantly decreases congestion of the hemorrhoidal plexus.

  12. Verdsettelse av Renewable Energy Corporation ASA

    OpenAIRE

    Dahlberg, Jonas; Fredriksen, Marius Sletbakk

    2011-01-01

    I denne bacheloroppgaven har vi hatt verdsettelse som tema, der vi har sett nærmere på Renewable Energy Corporation ASA(REC). Problemstillingen vår har vært: “Hva er verdien av Renewable Energy Corporation ASA 1.1.2011?” REC er en vertikalt integrert bedrift som produserer solenergi. De er et konsern som driver i alle deler av verdikjeden, fra produksjon av silisium – wafere – solceller – solcellepanel – solcellemoduler. Selskapet ble notert på Oslo Børs i 2006 til en aksjekurs på 107,5...

  13. 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets.

    Science.gov (United States)

    Goyanes, Alvaro; Buanz, Asma B M; Hatton, Grace B; Gaisford, Simon; Basit, Abdul W

    2015-01-01

    The aim of this study was to explore the potential of fused-deposition 3-dimensional printing (FDM 3DP) to produce modified-release drug loaded tablets. Two aminosalicylate isomers used in the treatment of inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA, mesalazine) and 4-aminosalicylic acid (4-ASA), were selected as model drugs. Commercially produced polyvinyl alcohol (PVA) filaments were loaded with the drugs in an ethanolic drug solution. A final drug-loading of 0.06% w/w and 0.25% w/w was achieved for the 5-ASA and 4-ASA strands, respectively. 10.5mm diameter tablets of both PVA/4-ASA and PVA/5-ASA were subsequently printed using an FDM 3D printer, and varying the weight and densities of the printed tablets was achieved by selecting the infill percentage in the printer software. The tablets were mechanically strong, and the FDM 3D printing was shown to be an effective process for the manufacture of the drug, 5-ASA. Significant thermal degradation of the active 4-ASA (50%) occurred during printing, however, indicating that the method may not be appropriate for drugs when printing at high temperatures exceeding those of the degradation point. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) of the formulated blends confirmed these findings while highlighting the potential of thermal analytical techniques to anticipate drug degradation issues in the 3D printing process. The results of the dissolution tests conducted in modified Hank's bicarbonate buffer showed that release profiles for both drugs were dependent on both the drug itself and on the infill percentage of the tablet. Our work here demonstrates the potential role of FDM 3DP as an efficient and low-cost alternative method of manufacturing individually tailored oral drug dosage, and also for production of modified-release formulations.

  14. A Brief History of the Soil Science Society of America

    Science.gov (United States)

    Brevik, Eric C.

    2013-04-01

    Career Professional Award. SSSA has also hosted the World Congress of Soil Science in 1960 and 2006. In 2010 SSSA membership was at 6,367, the third highest membership total in SSSA history. SSSAJ published 259 items totaling 2,201 pages. But unlike 1937, SSSAJ is no longer SSSA's only journal. In 2009 Journal of Environmental Quality published 272 items on 2,480 pages, Soil Survey Horizons (renamed Soil Horizons in 2012) published 26 items on 133 pages, Vadose Zone Journal published 116 items on 1,088 pages, and Journal of Natural Resources and Life Sciences Education published 48 items on 250 pages, giving Society journals a total of 721 items published on 6,132 pages. At the end of 2010 SSSA was worth 3,130,163. All of these numbers show significant achievement in the years since the Society's founding, but not all of those years have been rosy. For example, SSSA's membership dropped from an all-time high of 6,402 in 1985 to 5,319 in 2002 and the Society's net worth declined from 2,132,750 in 1999 to 984,866 in 2002. This period from the mid-1980s through the early 2000s has probably been the most challenging so far in SSSA's history. Many changes are also in store going into the future. Over the past few years SSSA has become increasingly independent from ASA. While the two societies (along with the Crop Science Society of America (CSSA)) still maintain close ties, the members of SSSA have expressed a desire to emphasize that soils are more than agronomic. One indication of this increasing independence can be seen in the annual meetings. SSSA met jointly with the Geological Society of America in 2008 and will meet with the Entomological Society of America in 2015. There are also plans for SSSA to meet independently of ASA and CSSA for the first time in 2018. Another indication is the recent rearrangement of the governing structures of ASA, CSSA, and SSSA.

  15. ASAS = NASA's Advanced Solid-state Array Spectroradiometer: 1988 -2000

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Advanced Solid-State Array Spectroradiometer (ASAS) data collection contains data collected by the ASAS sensor flown aboard NASA aircraft. A fundamental use of...

  16. Photometric Solutions of Some Contact ASAS Binaries

    CERN Document Server

    Gezer, I

    2015-01-01

    We present the first light curve solution of 6 contact binary systems which are chosen from the ASAS catalog. The photometric elements and the estimated absolute parameters of all systems are obtained with the light curve analyses. We calculated the values of degree of contact for the systems. The location of the targets on the Hertzsprung-Russell diagram and the mass-radius plane is compared to the other well-known contact binaries and the evolutionary status of the systems are also discussed.

  17. Photometric solutions of some contact ASAS binaries

    Science.gov (United States)

    Gezer, İ.; Bozkurt, Z.

    2016-04-01

    We present the first light curve solution of 6 contact binary systems which are chosen from the ASAS catalog. The photometric elements and the estimated absolute parameters of all systems are obtained with the light curve analyses. We calculated the values of degree of contact for the systems. The location of the targets on the Hertzsprung-Russell diagram and the mass-radius plane is compared to the other well-known contact binaries and the evolutionary status of the systems are also discussed.

  18. Coronal activity from the ASAS eclipsing binaries

    CERN Document Server

    Szczygiel, D M; Paczynski, B; Pojmanski, G; Pilecki, B

    2008-01-01

    We combine the catalogue of eclipsing binaries from the All Sky Automated Survey (ASAS) with the ROSAT All Sky Survey (RASS). The combination results in 836 eclipsing binaries that display coronal activity and is the largest sample of active binary stars assembled to date. By using the (V-I) colors of the ASAS eclipsing binary catalogue, we are able to determine the distances and thus bolometric luminosities for the majority of eclipsing binaries that display significant stellar activity. A typical value for the ratio of soft X-ray to bolometric luminosity is L_X/L_bol ~ a few x 10^-4, similar to the ratio of soft X-ray to bolometric flux F_X/F_bol in the most active regions of the Sun. Unlike rapidly rotating isolated late-type dwarfs -- stars with significant outer convection zones -- a tight correlation between Rossby number and activity of eclipsing binaries is absent. We find evidence for the saturation effect and marginal evidence for the so-called "super-saturation" phenomena. Our work shows that wide-...

  19. Pharmacokinetic study of a new oral buffered acetylsalicylic acid (ASA) formulation in comparison with plain ASA in healthy volunteers.

    Science.gov (United States)

    Viganò, G; Garagiola, U; Gaspari, F

    1991-01-01

    A single-blind, randomized, crossover pharmacokinetic study was carried out to investigate the bioavailability of a new oral buffered 325 mg acetylsalicylic acid (ASA) formulation (ASPIRINA 03) in comparison with a 325 mg plain tablet. Twelve healthy volunteers of both sexes, aged between 20 and 37 years, received buffered or plain ASA on two separate occasions with a wash-out interval of at least two weeks. ASA and salicylic acid (SA) plasma levels were determined by a chromatographic method. The results showed no difference between the area under concentration time curve (AUC0-infinity) ASA values of both formulations (p = 0.19), and buffered ASA relative bioavailability was 102.49% (= bioequivalence). A significant difference was found between the AUC0-30 min ASA values: 90.5 micrograms. min/ml with buffered and 67.7 micrograms. min/ml with the plain tablet (p less than 0.05). The buffered ASA time of maximum concentration was shorter (28 +/- 8 min) than the plain one (38 +/- 19 min, p less than 0.05). The plasma concentrations and pharmacokinetic parameters of SA were not significantly different after the administration of the two ASA formulations. The plain ASA tablet had a significantly lower (p less than 0.05) dissolution rate than buffered ASA tablet. Moreover, the buffered ASA tablet significantly (p less than 0.01) increased the pH by 0.5 units. In conclusion, the bioavailability of the new oral buffered ASA was equivalent to that of plain ASA, but the plasma concentration peak was reached in a shorter time. PMID:1809699

  20. Solvent accessible surface area (ASA) of simulated phospholipid membranes

    DEFF Research Database (Denmark)

    Tuchsen, E.; Jensen, Morten Østergaard; Westh, P.

    2003-01-01

    The membrane-solvent interface has been investigated through calculations of the solvent accessible surface area (ASA) for simulated membranes of DPPC and POPE. For DPPC at 52 degreesC we found an ASA of 126 +/- 8 Angstrom(2) per lipid molecule, equivalent to twice the projected lateral area...... compensated by increased exposure of the ethylene and phosphate moieties. The ASA of the polar moieties Of (PO4, NH3 and COO) constitutes 65% of the total accessible area for POPE, making this interface more polar than that of DPPC. It is suggested that ASA information can be valuable in attempts...

  1. DOF ASA : an offshore service company organized for expansion

    OpenAIRE

    Vad, Jan Tore; Engås, Aleksander

    2010-01-01

    The purpose of this thesis is a valuation of DOF ASA with a thorough analysis of the offshore service market. The valuation is based on public available information up until November 2010, and discussions with CFO Hilde Drønnen at DOF ASA. The market analysis is based on reports and presentations obtained from various Norwegian investment houses that cover the offshore service and subsea market. We will compile and use them as input in a market model. The market analysis conclu...

  2. Overview of 5-ASA in Therapy of Inflammatory Bowel Disease

    Directory of Open Access Journals (Sweden)

    CN Williams

    1994-01-01

    Full Text Available There are two forms of 5-aminosalicylic acid (5-ASA drug delivery. First, a pro-drug form in which 5-ASA, the active principal, is attached to a c.arrier molecule and released in the intestine by bacterial cleavage. An example of this is sulfasalazine, originally developed in the 1940s and found to be effective, cheap, but limited by side effects due to the sulfapyridine component. The second drug delivery system depends on an enteric coating for delayed pH-dependent release or for a timed-released mechanism. 5-ASA inhibits 5-lipoxygenase, modulates leukocyte function and inhibits soluble mediator release, and is an effective scavenger action of free oxygen radicals, the relative importance of which is unknown. The multiplicity of action is probably its strength because drugs that have only one of these actions are relatively ineffective in inflammatory bowel disease. 5-ASA compounds are effective in treating mild to moderate acute ulcerative colitis and in maintaining remission, and are equivalent to sulfasalazine in this regard. 5-ASA used topically in enema or suppository form is highly efficient in both acute disease and in maintaining remission. 5-ASA is also effective in active Crohn’s disease, but not as effective as in maintenance therapy compared with ulcerative colitis. The pro-drugs tend to have more side effects. Slow release compounds are well tolerated with few side effects, allowing increases to effective dosage. In patients intolerant of sulfasalazine, switching to a 5-ASA preparation usually results in tolerance and therapeutic benefit, with an occasional allergic reaction to the 5-ASA molecule limiting its use.

  3. The ASAS-SN Bright Supernova Catalog $-$ II. 2015

    CERN Document Server

    Holoien, T W -S; Stanek, K Z; Kochanek, C S; Shappee, B J; Prieto, J L; Dong, Subo; Brimacombe, J; Bishop, D W; Basu, U; Beacom, J F; Bersier, D; Chen, Ping; Danilet, A B; Falco, E; Godoy-Rivera, D; Goss, N; Pojmanski, G; Simonian, G V; Skowron, D M; Thompson, Todd A; Woźniak, P R; Avíla, C G; Bock, G; Carballo, J -L G; Conseil, E; Contreras, C; Cruz, I; andújar, J M F; Guo, Zhen; Hsiao, E Y; Kiyota, S; Koff, R A; Krannich, G; Madore, B F; Marples, P; Masi, G; Morrell, N; Monard, L A G; Munoz-Mateos, J C; Nicholls, B; Nicolas, J; Wagner, R M; Wiethoff, W S

    2016-01-01

    This manuscript presents information for all supernovae discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN) during 2015, its second full year of operations. The same information is presented for bright ($m_V\\leq17$), spectroscopically confirmed supernovae discovered by other sources in 2015. As with the first ASAS-SN bright supernova catalog, we also present redshifts and near-UV through IR magnitudes for all supernova host galaxies in both samples. Combined with our previous catalog, this work comprises a complete catalog of 455 supernovae from multiple professional and amateur sources, allowing for population studies that were previously impossible. This is the second of a series of yearly papers on bright supernovae and their hosts from the ASAS-SN team.

  4. Predictive validity of the ASAS classification criteria for axial and peripheral spondyloarthritis after follow-up in the ASAS cohort

    DEFF Research Database (Denmark)

    Sepriano, Alexandre; Landewé, Robert; van der Heijde, Désirée;

    2016-01-01

    OBJECTIVE: To establish the predictive validity of the Assessment of SpondyloArthritis international Society (ASAS) spondyloarthritis (SpA) classification criteria. METHODS: 22 centres (N=909 patients) from the initial 29 ASAS centres (N=975) participated in the ASAS-cohort follow-up study....... Patients had either chronic (>3 months) back pain of unknown origin and age of onset below 45 years (N=658) or peripheral arthritis and/or enthesitis and/or dactylitis (N=251). At follow-up, information was obtained at a clinic visit or by telephone. The positive predictive value (PPV) of the baseline...... 4 years is excellent. The 'imaging arm' and 'clinical arm' of the axSpA criteria have similar predictive validity and are truly complementary....

  5. ASAS classification criteria for axial spondyloarthritis: time to modify.

    Science.gov (United States)

    Akkoc, Nurullah; Khan, Muhammad A

    2016-06-01

    The relationship between ankylosing spondylitis and the recently proposed entity called axial spondyloarthritis with its radiographic and non-radiographic forms that have been defined by the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (axSpA), is currently being debated. The Food and Drug Agency (FDA) had criticized the ASAS criteria and the studies which used these criteria to enroll patients in a clinical trial of certolizumab and adalimumab for the treatment of non-radiographic axial spondyloarthritis. The primary aim of classification criteria is to create homogenous patient populations for basic and clinical research. But the multi-arm construct of the ASAS criteria is a potential source of heterogeneity reducing their utility. Criteria sets should be regarded as dynamic concepts open to modifications or updates as our knowledge advances. We provide evidence to conclude that it is time to modify the ASAS Criteria for axSpA, and we propose some of the steps that can be taken to start moving forward in improving the validity of these criteria. PMID:27094940

  6. Multiperiodic Galactic field RR Lyrae stars in the ASAS catalog

    CERN Document Server

    Szczygiel, D M

    2007-01-01

    The All Sky Automated Survey (ASAS) monitors bright stars (8 mag < V < 14 mag) south of declination +28 deg. The ASAS Catalogue of Variable Stars (ACVS) presently contains 50,099 objects; among them are 2212 objects classified as RR Lyrae pulsating variables. We use ASAS photometric V band data to search for multiperiodicity in those stars. We find that 73 of 1435 RRab stars and 49 of 756 RRc stars exhibit the Blazhko effect. We observe a deficiency of RRab Blazhko variables with main pulsation periods greater than 0.65 days. The Blazhko periods of RRc stars exhibit a strongly bimodal distribution. During our study we discovered the Blazhko effect with multiple periods in object ASAS 050747-3351.9 = SU Col. Blazhko periods of 89.3 d and 65.8 d and a candidate of 29.5 d were identified with periodogram peaks near the first three harmonics of the main pulsation. These observations may inspire new models of the Blazhko effect, which has eluded a consistent theory since its discovery about one hundred years...

  7. Nanometer aerosol size analyzer (nASA) and data inversion

    Science.gov (United States)

    Han, Hee Siew

    A fast-response Nanometer Aerosol Size Analyzer (nASA) that is capable of scanning 30 size channels between 3 and 100 nm in a total time of 3 seconds was developed. The analyzer includes a bipolar charger (Po 210), an extended-length Nano DMA, and an electrometer. This combination of components provides particle size spectra at a scan rate of 0.1 second per channel free of uncertainties caused by response-time induced smearing. In addition, because of its thermodynamically stable means of particle detection, the nASA is useful for applications requiring measurements over a broad range of sample pressures and temperatures. Indeed, experimental transfer functions determined for the extended-length Nano-DMA using the Tandem Differential Mobility Analyzer technique indicate the nASA provides good size resolution at pressures as low as 200 Torr, corresponding to measurement at an altitude of 10 km. The second part of this study is devoted to the selection of an accurate data inversion algorithm. From the simulation results, it is found that MICRON provides the most stable solutions with good accuracy and reasonable convergent speed especially when aerosol distribution functions are bi-modal. All subsequent nASA measurement results are inverted using the MICRON algorithm. A second generation nASA was developed for the later series of engine exhaust measurements. Several improvements are implemented to the nASA to enhance its performance and ease of use. First, its physical size is reduced and the capability for controlling the DMA flow rates via computer software is added. The former improves the portability of the instrument and the latter allows the nASA to have an wider aerosol size ranges. Finally, the system was used in the EXperiment to Characterize Aircraft Volatile Aerosol and Trace species Emissions (EXCAVATE) workshop to investigate aerosol size distribution from a Boeing 757 engine. The results show that the aerosol size distributions from the engine are

  8. Design and characterization of a chimeric multiepitope construct containing CfaB, heat-stable toxoid, CssA, CssB, and heat-labile toxin subunit B of enterotoxigenic Escherichia coli: a bioinformatic approach.

    Science.gov (United States)

    Zeinalzadeh, Narges; Salmanian, Ali Hatef; Ahangari, Ghasem; Sadeghi, Mahdi; Amani, Jafar; Bathaie, S Zahra; Jafari, Mahyat

    2014-01-01

    Enterotoxigenic Escherichia coli (ETEC) strains are the most common cause of bacterial diarrhea in children in developing countries and travelers to these areas. Enterotoxins and colonization factors (CFs) are two key virulence factors in ETEC pathogenesis, and the heterogeneity of the CFs is the bottleneck in reaching an effective vaccine. In this study, a candidate subunit vaccine, which is composed of CfaB, CssA and CssB, structural subunits of colonization factor antigen I and CS6 CFs, labile toxin subunit B, and the binding subunit of heat-labile and heat-stable toxoid, was designed to provide broad-spectrum protection against ETEC. The different features of chimeric gene, its mRNA stability, and chimeric protein properties were analyzed by using bioinformatic tools. The optimized chimeric gene was chemically synthesized and expressed successfully in a prokaryotic host. The purified protein was used for assessment of bioinformatic data by experimental methods.

  9. Multiples among detached eclipsing binaries from the ASAS catalog

    CERN Document Server

    Hełminiak, K G; Ratajczak, M; Jordán, A; Espinoza, N; Brahm, R; Kambe, E; Ukita, N

    2015-01-01

    For more than three years now we have been conducting a spectroscopic survey of detached eclipsing binaries (DEBs) from the All-Sky Automated Survey (ASAS) database. Thousands of high-resolution spectra of over 300 systems were secured, and used for radial velocity measurements and spectral analysis. In our sample we found a zoo of multiple systems, such as spectroscopic triples and quadruples, visual binaries with eclipsing components, and circumbinary low-mass companions, including sub-stellar-mass candidates

  10. Effects of acetylsalicylic acid (ASA), ASA plus L-glutamine and L-glutamine on healing of chronic gastric ulcer in the rat.

    Science.gov (United States)

    Okabe, S; Takeuchi, K; Honda, K; Takagi, K

    1976-01-01

    A chronic gastric ulcer model was produced in rats by the subserosal injection of 20% acetic acid solution (0.015 ml) in order to examine whether (1) acetylsalicylic acid (ASA) irritates the chronic gastric ulcer in active or healed or diminished stage, (2) L-glutamine, given together with ASA, inhibits the adverse effect of ASA. Oral ASA 200 mg/kg/day, given in two divided doses for 10 consecutive days, apparently delayed the healing of the gastric ulcer and irritated the healed ulcer to reulcerate. L-Glutamine, 1,500 mg/kg/day, which was given together with ASA in two divided doses, markedly protected the gastric ulcer both in active and healed stages from the deleterious activity of ASA. PMID:955326

  11. Norwegian air shuttle ASA : strategisk regnskapsanalyse og verdsettelse

    OpenAIRE

    Varhaug, Erik; Torgersen, Jan-Tore Susort

    2013-01-01

    Denne masteroppgaven er en fundamental verdsettelse av Norwegian Air Shuttle ASA, heretter kalt Norwegian. Oppgavens mål er å vurdere om selskapets aksjekurs per 16.02.2015 på NOK 228,70 kan rettferdiggjøres basert på selskapets underliggende økonomiske forhold. Den fundamentale verdsettelsen vil suppleres av en komparativ verdsettelse for å kunne sammenligne og vurdere rimeligheten av verdsettelsesanslagene. Oppgaven starter med en kort introduksjon av flybransjen før Norwegian og selskap...

  12. Impact of an increasing supply of bioenergy sources on the sustainability of agricul-tural enterprises, evaluated with the Criteria System for Sustainable Agriculture (CSSA); Folgenabschaetzung einer zunehmenden Bereitstellung von Bioenergietraegern auf die Nachhaltigkeit landwirtschaftlicher Unternehmen, bewertet mit dem Kriteriensystem Nachhaltige Landwirtschaft (KSNL)

    Energy Technology Data Exchange (ETDEWEB)

    Breitschuh, Thorsten; Eckert, Hans; Maier, Uta; Gernand, Ulrich; Mueller, Anja [Thueringer Landesanstalt fuer Landwirtschaft (TLL), Jena (Germany); Verband fuer Agrarforschung und Bildung Thueringen e.V., Jena (Germany)

    2009-07-15

    The report investigates how an increasing supply of bioenergy sources affects the sustainability situation of farms at different sites and with different structures. The ''Criteria System for Sustainable Agriculture'' (CSSA) was used as analysis and assessment criteria system. The CSSA is based on 34 selected criteria in the field of economy, environment and social conditions. Each criterion indicates a defined pres-sure or state and evaluates the results on the basis of defined tolerance ranges. In the study short-term scenarios of an increasing provision of bioenergy based on real data from agricultural farms were evaluated with the CSSA system. Altogether, 30 scenarios were analysed. As a result the most sustainable scenario for the supply of bioenergy was identified for each farm considered. Using this approach, the most important adaptation reactions of agricultural enterprises were determined and evaluated. Potential applications of the explained procedure are the ex-ante simulation and ex- ante evaluation of agricultural processes and the creation and evaluation of sup-port programmes. (orig.)

  13. 78 FR 32477 - ASA Gold and Precious Metals Limited; Notice of Application

    Science.gov (United States)

    2013-05-30

    ... ASA to achieve its desired international portfolio diversification. \\13\\ Rule 17f-5 permits a U.S... strategy consistent with its current fundamental investment policy and to achieve its desired portfolio diversification outside of South Africa. Applicant asserts that with the requested relief ASA will be able...

  14. The ASAS-SN Bright Supernova Catalog I: 2013-2014

    Science.gov (United States)

    Holoien, T. W.-S.; Stanek, K. Z.; Kochanek, C. S.; Shappee, B. J.; Prieto, J. L.; Brimacombe, J.; Bersier, D.; Bishop, D. W.; Dong, Subo; Brown, J. S.; Danilet, A. B.; Simonian, G. V.; Basu, U.; Beacom, J. F.; Falco, E.; Pojmanski, G.; Skowron, D. M.; Woźniak, P. R.; Ávila, C. G.; Conseil, E.; Contreras, C.; Cruz, I.; Fernández, J. M.; Koff, R. A.; Guo, Zhen; Herczeg, G. J.; Hissong, J.; Hsiao, E. Y.; Jose, J.; Kiyota, S.; Long, Feng; Monard, L. A. G.; Nicholls, B.; Nicolas, J.; Wiethoff, W. S.

    2016-09-01

    We present basic statistics for all supernovae discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN) during its first year-and-a-half of operations, spanning 2013 and 2014. We also present the same information for all other bright (mV ≤ 17), spectroscopically confirmed supernovae discovered from 2014 May 1 through the end of 2014, providing a comparison to the ASAS-SN sample starting from the point where ASAS-SN became operational in both hemispheres. In addition, we present collected redshifts and near-UV through IR magnitudes, where available, for all host galaxies of the bright supernovae in both samples. This work represents a comprehensive catalog of bright supernovae and their hosts from multiple professional and amateur sources, allowing for population studies that were not previously possible because the all-sky emphasis of ASAS-SN redresses many previously existing biases. In particular, ASAS-SN systematically finds bright supernovae closer to the centers of host galaxies than either other professional surveys or amateurs, a remarkable result given ASAS-SN's poorer angular resolution. This is the first of a series of yearly papers on bright supernovae and their hosts that will be released by the ASAS-SN team.

  15. Geriatric Hip Fractures and Inpatient Services: Predicting Hospital Charges Using the ASA Score

    Directory of Open Access Journals (Sweden)

    Rachel V. Thakore

    2014-01-01

    Full Text Available Purpose. To determine if the American Society of Anesthesiologist (ASA score can be used to predict hospital charges for inpatient services. Materials and Methods. A retrospective chart review was conducted at a level I trauma center on 547 patients over the age of 60 who presented with a hip fracture and required operative fixation. Hospital charges associated with inpatient and postoperative services were organized within six categories of care. Analysis of variance and a linear regression model were performed to compare preoperative ASA scores with charges and inpatient services. Results. Inpatient and postoperative charges and services were significantly associated with patients’ ASA scores. Patients with an ASA score of 4 had the highest average inpatient charges of services of $15,555, compared to $10,923 for patients with an ASA score of 2. Patients with an ASA score of 4 had an average of 45.3 hospital services compared to 24.1 for patients with a score of 2. Conclusions. A patient’s ASA score is associated with total and specific hospital charges related to inpatient services. The findings of this study will allow payers to identify the major cost drivers for inpatient services based on a hip fracture patient’s preoperative physical status.

  16. The Best and the Brightest: Tidal Disruption Events Discovered by ASAS-SN

    Science.gov (United States)

    Warren-Son Holoien, Thomas; ASAS-SN

    2016-01-01

    Even today only human eyes scan the entire optical sky for the violent, variable, and transient events that shape our universe. The All-Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin") is changing this by monitoring the visible sky to 17th magnitude every 2-3 days using multiple telescopes in the northern and southern hemispheres. Having been in operation for two years, ASAS-SN is discovering new transient objects daily, and while the primary goal of ASAS-SN is a complete survey of bright, nearby supernovae, ASAS-SN also discovers many other interesting nearby transients. Notably, ASAS-SN has discovered three bright tidal disruption events (TDEs), the three closest such events ever discovered at optical wavelengths, providing the opportunity to obtain detailed follow-up data at many wavelengths. ASAS-SN is discovering roughly 1 TDE for every 60 Type Ia supernovae, a rate that is significantly higher than other surveys. By virtue of their brightness, TDEs discovered by ASAS-SN can also be studied in unprecedented detail for many months, allowing deeper insight into their physics.

  17. ASA conference on radiation and health, Coolfont VI: Final report

    International Nuclear Information System (INIS)

    The 1986 ASA Conference on Radiation and Health (Coolfont VI) continued the procedure established in 1981 of holding forenoon and evening sessions, leaving afternoons free for discussion and relaxation. One exception was made this year in that Michael and Marie Stoline were invited to discuss the Chernobyl Disaster on Monday afternoon. The program consisted of the following topics: a general overview of radiation and health problems; cytogenetics and radiation (human and animal studies and statistical analysis of dose-response curves); uranium and health effects, including continuing emphasis on radon, which has attracted considerable national interest lately; epidemiologic studies of workers at nuclear power plants and an uranium processing plant; the latest assessment of atomic bomb dosimetry. These Coolfont Conferences provide an excellent environment for an interchange of ideas and information in an assemblage of scientists from a variety of disciplines. Unfortunately there is one important factor which limits this interchange: language. In order to overcome the difficulty of statisticians understanding nuclear scientists and nuclear scientists understanding statisticians, I suggested one of two procedures: each group prepare a set of commonly used terms with definitions which would be understood by the other group(s); have an introductory session in which each group attempts to explain its language to the other group(s). This problem of communication is even more serious when scientists attempt to explain their research efforts to the general public. The Coolfont Conferences on Radiation and Health should be ideal forums for development of a language which could be understood by the general public as well as different scientific groups. This document contains the abstracts of 12 presented papers

  18. ASA conference on radiation and health: Coolfont 7: Final report

    International Nuclear Information System (INIS)

    These proceedings provide a summary of papers presented at the seventh annual ASA Conference on Radiation and Health, held at the Coolfont Conference Center in Berkeley Springs, West Virginia. More than forty scientists, including statisticians, epidemiologists, biologists, and physicists, participated in the conference. The 1987 conference focused on lung cancer risks, especially lung cancer risks due to radon. The BEIR IV report, which addresses health risks of radon and other internally deposited alpha-emitters, was summarized early in the conference. Results of analyses of data on miners in Colorado and in New Mexico were presented, as well as analyses of combined data from several studies, which were used as the basis of estimates in the BEIR IV report. Statistical issues related to appropriate analysis of chronic exposure and of smoking data received considerable attention and discussion. Papers describing models for lung cancer risks based on exposure to cigarette smoke, radiation, and other substances provided insights into general understanding of lung cancer mechanisms. Carcinogenic models were also the subject of a presentation on radiation-induced skin cancer in humans and animals. In addition, relevant data on animal experiments involving radon exposure were summarized. Understanding risks requires relating them to dose, and thus the presentation on dosimetry, both for miner populations and for residents of US homes, made an important contribution to the conference. Presentations on current efforts at the state and national level to assess radon levels in US homes were also of considerable interest to the participants. Individual papers were processed separately for the data base

  19. Crystallization and preliminary X-ray diffraction studies of AsaP1_E294A and AsaP1_E294Q, two inactive mutants of the toxic zinc metallopeptidase AsaP1 from Aeromonas salmonicida subsp. achromogenes

    OpenAIRE

    Bogdanović, Xenia; Singh, Rajesh Kumar; Hentschke, Johanna; Gudmundsdóttir, Bjarnheidur K.; Hinrichs, Winfried

    2009-01-01

    Crystallization and preliminary X-ray diffraction studies of AsaP1_E294A and AsaP1_E294Q, two inactive mutants of the toxic zinc metallopeptidase AsaP1 from A. salmonicida subsp. achromogenes, are reported.

  20. ASA Kindlustus loodab lepingud kahe nädalaga Tšiili firmale anda / Margus Simson

    Index Scriptorium Estoniae

    Simson, Margus

    1999-01-01

    ASA Kindlustus ja AB Elukindlustus loodavad, et seltside tegevuslitsentside tühistamine lükatakse edasi veel kahe nädala võrra, kindlustusportfellide üleandmine Tšiili firmale Pacific Overseas Group

  1. Comparison of intraoperative and postoperative complications based on ASA risks in patients who underwent percutaneous nephrolithotomy

    Science.gov (United States)

    Karakaş, Hüseyin Buğra; Çiçekbilek, İzzet; Tok, Adem; Alışkan, Tamer; Akduman, Bülent

    2016-01-01

    Objective In this study we aimed to evaluate intraoperative and postoperative complications which developed according to pre-operative American Society of Anesthesiologists (ASA) risk criteria in patients who had undergone percutaneous nephrolithotomy (PNL). Material and methods Five hundred and sixty patients who had undergone PNL between 2002 and 2014 were included in the study. Patients operated on the ipsilateral kidney, those with solitary kidney or the cases who had previously undergone more than one access were excluded from this study. Preoperative anesthesia risks were determined according to preoperative classification developed by ASA. Postoperative complications were evaluated using Clavien Complication Grading Scale. Results The mean age of the cases was 47±14 years. The 57% (n=319) of the cases were male, 241 (43%) of them were female. The average indwell time of nephrostomy catheter was 2.88±1.00 (1–8), and length of hospital stay was 4.91±1.54 (2–17) days. When the cases were assessed according to ASA risk groups, intraoperative complications were observed in 9 (5.5%) ASA I, 27 (8.6%) ASA II, and 18 (22%) ASA III patients and and distribution of the patients was statistically significant (pPNL operations in terms of intraoperative complications. PMID:27635291

  2. The mosaic architecture of Aeromonas salmonicida subsp. salmonicida pAsa4 plasmid and its consequences on antibiotic resistance

    Science.gov (United States)

    Tanaka, Katherine H.; Vincent, Antony T.; Trudel, Mélanie V.; Paquet, Valérie E.; Frenette, Michel

    2016-01-01

    Aeromonas salmonicida subsp. salmonicida, the causative agent of furunculosis in salmonids, is an issue especially because many isolates of this bacterium display antibiotic resistances, which limit treatments against the disease. Recent results suggested the possible existence of alternative forms of pAsa4, a large plasmid found in A. salmonicida subsp. salmonicida and bearing multiple antibiotic resistance genes. The present study reveals the existence of two newly detected pAsa4 variants, pAsa4b and pAsa4c. We present the extensive characterization of the genomic architecture, the mobile genetic elements and the antimicrobial resistance genes of these plasmids in addition to the reference pAsa4 from the strain A449. The analysis showed differences between the three architectures with consequences on the content of resistance genes. The genomic plasticity of the three pAsa4 variants could be partially explained by the action of mobile genetic elements like insertion sequences. Eight additional isolates from Canada and Europe that bore similar antibiotic resistance patterns as pAsa4-bearing strains were genotyped and specific pAsa4 variants could be attributed to phenotypic profiles. pAsa4 and pAsa4c were found in Europe, while pAsa4b was found in Canada. In accordance with their content in conjugative transfer genes, only pAsa4b and pAsa4c can be transferred by conjugation in Escherichia coli. The plasticity of pAsa4 variants related to the acquisition of antibiotic resistance indicates that these plasmids may pose a threat in terms of the dissemination of antimicrobial-resistant A. salmonicida subsp. salmonicida bacteria. PMID:27812409

  3. The ASAS-SN Bright Supernova Catalog I: 2013-2014

    CERN Document Server

    Holoien, T W -S; Kochanek, C S; Shappee, B J; Prieto, J L; Brimacombe, J; Bersier, D; Bishop, D W; Dong, Subo; Brown, J S; Danilet, A B; Simonian, G V; Basu, U; Beacom, J F; Falco, E; Pojmanski, G; Skowron, D M; Wozniak, P R; Avila, C G; Conseil, E; Contreras, C; Cruz, I; Fernandez, J M; Koff, R A; Guo, Zhen; Herczeg, G J; Hissong, J; Hsiao, E Y; Jose, J; Kiyota, S; Long, Feng; Monard, L A G; Nicholls, B; Nicolas, J; Wiethoff, W S

    2016-01-01

    We present basic statistics for all supernovae discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN) during its first year-and-a-half of operations, spanning 2013 and 2014. We also present the same information for all other bright ($m_V\\leq17$), spectroscopically confirmed supernovae discovered from 2014 May 1 through the end of 2014, providing a comparison to the ASAS-SN sample starting from the point where ASAS-SN became operational in both hemispheres. In addition, we present collected redshifts and near-UV through IR magnitudes, where available, for all host galaxies of the bright supernovae in both samples. This work represents a comprehensive catalog of bright supernovae and their hosts from multiple professional and amateur sources, allowing for population studies that were not previously possible because the all-sky emphasis of ASAS-SN redresses most previously existing biases. In particular, ASAS-SN systematically finds supernovae closer to the centers of host galaxies than either other...

  4. Pharmacokinetics and tissue distribution of 14C-5-aminosalicylic acid (14C-5-ASA) in rats

    International Nuclear Information System (INIS)

    5-Aminosalicylic acid (5-ASA) is effective in the treatment of ulcerative colitis and Crohn's disease. As part of a preclinical metabolism profile with 5-ASA, we evaluated the tissue level and distribution of 14C-5-ASA in rats. Biodistribution of 14C-radioactivity was determined in the major organs of rats after a single oral dose (34 mg/kg; 15 uci/rat). Data from tissue area under the curve (AUC 0-72) indicated that the highest amounts of radioactivity were retained in cecum (481.1 hr.ug.equ/gm), colon-rectum (178.5 hr.ug.equ/gm), ileum (166.7 hr.ug.equ/gm), jejunum (65.5 hr.ug.equ/gm), followed by kidneys (58.0 hr.ug.equ/gm) and liver (14.8 hr.ug.equ/gm). The radioactivity retained in tissues at 72 hours postdose was wither nondetectable or less than 0.1 ppm. The radioactivity concentration in blood was highest at 0.5 hr (tmax) postdose and the terminal half-life (t1/2) of 14C-radioactivity (5-ASA + metabolite) was 2.7 hours. 14C-5-ASA is absorbed and distributed in the body. The greatest amount of 14C-radioactivity was found in the stomach and GI tract. 14C-5-ASA was eliminated completely (44.9% in the urine, 51.7% in the feces) 72 hours after administration without significant tissue retention

  5. All Source Analysis System (ASAS): Migration from VAX to Alpha AXP computer systems

    Science.gov (United States)

    Sjoholm-Sierchio, Michael J.; Friedman, Steven Z. (Editor)

    1994-01-01

    The Jet Propulsion Laboratory's (JPL's) experience migrating existing VAX applications to Digital Equipment Corporation's new Alpha AXP processor is covered. The rapid development approach used during the 10-month period required to migrate the All Source Analysis System (ASAS), 1.5 million lines of FORTRAN, C, and Ada code, is also covered. ASAS, an automated tactical intelligence system, was developed by the Jet Propulsion Laboratory for the U. S. Army. Other benefits achieved as a result of the significant performance improvements provided by Alpha AXP platform are also described.

  6. VODENJE EVIDENCE DELOVNEGA ČASA S POMOČJO PAMETNE URE SAMSUNG GEAR S

    OpenAIRE

    Štravs, Rok

    2015-01-01

    Diplomsko delo obsega raziskavo na področju vodenja evidence delovnega časa delavcev ter izdelavo aplikacije. Vodenje delovnega časa temelji na dveh skupinah, in sicer skupini delavcev in delodajalcev. Vsak delavec se lahko prijavi in odjavi z dela ter ima možnost vpogleda v svoje opravljeno delo. Delodajalci imajo omogočen nadzor in pregled nad opravljenim delov vseh svojih delavcev. Pregled dela omogoča spletna aplikacija izdelana v tehnologiji ASP.NET MVC. Prijava in odjava na delo pa se o...

  7. Making a Theist out of Darwin: Asa Gray's Post-Darwinian Natural Theology

    Science.gov (United States)

    Hunter, T. Russell

    2012-01-01

    In March of 1860 the eminent Harvard Botanist and orthodox Christian Asa Gray began promoting the Origin of Species in hopes of securing a fair examination of Darwin's evolutionary theory among theistic naturalists. To this end, Gray sought to demonstrate that Darwin had not written atheistically and that his theory of evolution by natural…

  8. Quorum sensing in Aeromonas salmonicida subsp. achromogenes and the effect of the autoinducer synthase AsaI on bacterial virulence

    DEFF Research Database (Denmark)

    Schwenteit, Johanna; Gram, Lone; Nielsen, Kristian Fog;

    2011-01-01

    -acyl-homoserinelactone (AHL) monitor bacteria. HPLC–HR-MS analysis identified only one type of AHL, N-butanoyl-L-homoserine lactone (C4-HSL). A knock out mutant of AsaI, constructed by allelic exchange, did not produce a detectable QS signal and its virulence in fish was significantly impaired, as LD50 of the Asa...

  9. Acetylsalicylic acid (ASA) - How much, how often, and when? A clinical-pharmacological perspective.

    Science.gov (United States)

    Loew, Dieter; Belz, Gustav G

    2016-08-01

    The dose of acetylsalicylic acid (ASA) commonly used in the prevention and treatment of arteriosclerotic angiopathies is equal to or less than 100 mg daily. This choice of dose is predominantly based on molecular-pharmacological findings showing an inhibition in synthesis of the prothrombotic thromboxane (TXB2) and an irreversible inhibition in blood platelet aggregation. However, an analysis of ASA dose-effect relationships for doses of 50 - 500 mg (PO and IV) shows that doses of ASA up to 100 mg daily produce only a small or moderate inhibition in collagen/epinephrine-induced platelet aggregation and have no significant effect on the important platelet factors, PF3 and PF4. Doses of ASA 300 - 500 mg, on the other hand, inhibit platelet aggregation almost completely and, in addition, produce a 50 - 70% inhibition in PF3 and PF4 lasting at least 24 hours. There is also evidence that doses of ASA above 100 mg daily markedly inhibit thromboxane synthesis for up to 24 hours and that doses of 500 mg daily produce a clinically relevant inhibition in platelet adhesion to vessel walls for up 72 hours and prevent procoagulatory shape changes for up to 12 hours. These findings suggest that a dose of ≥ 300 mg at intervals of 2 - 3 days would be more appropriate for primary and secondary prophylaxis of arteriosclerotic angiopathies and that the benefit-risk ratio would be greater because of the increased availability of mucoprotective prostaglandins, PGI2 (prostacyclin) and the gastroprotective, PGE2. Our viewpoint, predominantly based on findings with biomarkers, could serve as a basis for further randomized controlled studies.

  10. The influence of the combined treatment with Vadimezan (ASA404 and taxol on the growth of U251 glioblastoma xenografts

    Directory of Open Access Journals (Sweden)

    Milanović Dušan

    2012-06-01

    Full Text Available Abstract Background One of the most important biological characteristics of Glioblastoma multiforme (GBM is high vascular density. Vadimezan (ASA404, DMXAA belongs to the class of small molecule vascular disrupting agents (VDA that cause disruption of established tumor vessels and subsequent tumor hemorrhagic necrosis. Its selective antivascular effect is mediated by intratumoral induction of several cytokines including tumor necrosis factor-α (TNF-α, granulocyte-colony-stimulating factor (G-CSF, interleukin 6 (IL-6 and macrophage inflammatory protein 1α (MIP-1α. Preclinical studies have demonstrated that ASA404 acts synergistically with taxanes. In this study, we investigated if treatment of mice bearing U251 human glioblastoma xenografts with ASA404 and taxol may be synergistic. Therapy response was evaluated by measuring changes in tumor size and metabolic activity using 18F-FDG PET (Fluorodeoxyglucose - positron emision tomography imaging. Methods U251 cells were inoculated s.c. in the right hind limb of NMRI-Foxn1nu athymic female nude mice. Animals were randomly assigned into 4 groups (7–9 animals/group for treatment: control, taxol, ASA404, and ASA404 plus taxol. The animals received either a single dose of taxol (10 mg/kg, ASA404 (27.5 mg/kg, or taxol (10 mg/kg plus ASA404 (27.5 mg/kg administered i.p.; ASA404 was administred 24 h after the treatment with taxol. 4 and 24 h after treatment with ASA404 (28 and 48 h hours after treatment with taxol 18 F-FDG PET scans were performed. Results The treatment with taxol did not affect the tumor growth in comparison to untreated controls. The treatment of animals with single dose ASA404 alone or in combination with taxol caused a significant delay in tumor growth. The combined treatment did not decrease the growth of the xenografts significantly more than ASA404 alone, but early changes in tumor 18 F-FDG uptake preceded subsequent growth inhibition. The tumor weights

  11. The influence of the combined treatment with Vadimezan (ASA404) and taxol on the growth of U251 glioblastoma xenografts

    International Nuclear Information System (INIS)

    One of the most important biological characteristics of Glioblastoma multiforme (GBM) is high vascular density. Vadimezan (ASA404, DMXAA) belongs to the class of small molecule vascular disrupting agents (VDA) that cause disruption of established tumor vessels and subsequent tumor hemorrhagic necrosis. Its selective antivascular effect is mediated by intratumoral induction of several cytokines including tumor necrosis factor-α (TNF-α), granulocyte-colony-stimulating factor (G-CSF), interleukin 6 (IL-6) and macrophage inflammatory protein 1α (MIP-1α). Preclinical studies have demonstrated that ASA404 acts synergistically with taxanes. In this study, we investigated if treatment of mice bearing U251 human glioblastoma xenografts with ASA404 and taxol may be synergistic. Therapy response was evaluated by measuring changes in tumor size and metabolic activity using 18F-FDG PET (Fluorodeoxyglucose - positron emision tomography) imaging. U251 cells were inoculated s.c. in the right hind limb of NMRI-Foxn1nu athymic female nude mice. Animals were randomly assigned into 4 groups (7–9 animals/group) for treatment: control, taxol, ASA404, and ASA404 plus taxol. The animals received either a single dose of taxol (10 mg/kg), ASA404 (27.5 mg/kg), or taxol (10 mg/kg) plus ASA404 (27.5 mg/kg) administered i.p.; ASA404 was administred 24 h after the treatment with taxol. 4 and 24 h after treatment with ASA404 (28 and 48 h hours after treatment with taxol) 18 F-FDG PET scans were performed. The treatment with taxol did not affect the tumor growth in comparison to untreated controls. The treatment of animals with single dose ASA404 alone or in combination with taxol caused a significant delay in tumor growth. The combined treatment did not decrease the growth of the xenografts significantly more than ASA404 alone, but early changes in tumor 18 F-FDG uptake preceded subsequent growth inhibition. The tumor weights, which were determined at the end of treatment, were lower in

  12. Controlled Release of 5-Aminosalicylic Acid (5-ASA from New Biodegradable Polyurethanes

    Directory of Open Access Journals (Sweden)

    El-Refaie Kenawy

    2010-03-01

    Full Text Available Segmented polyurethanes containing azo aromatic groups in the main chain were synthesized by reaction of 3,3'-azobis(6-hydroxybenzoic acid (ABHB, 5-[4-(hydroxyphenylazo] salicylic acid (HPAS, and 5-[1-hydroxynaphthylazo] salicylic acid (HNAS with hexamethylenediisocyanate (HDI. All synthesized monomers and polymers were characterized by elemental analysis, FTIR, 1H-NMR spectra, TGA and DSC analysis. All the synthesized azo polymers showed good thermal stability and the onset decomposition temperature of all these polymers was found to be above 195 ºC under nitrogen atmosphere.The release of 5-ASA under physiological conditions (pH = 7.8 and pH = 1.5 was investigated at body temperature (37 ºC. The release rate of 5-ASA increased with increasing pH (i.e., 7.8 > 1.5.

  13. Entry and operation modes of international oil companies : focus on Statoil ASA

    OpenAIRE

    Skogekker, Marius Haug

    2009-01-01

    This paper examines entry and operation modes of international oil companies on the Norwegian Continental Shelf, in the Gulf of Mexico, in Brazil and in Russia. The theoretical basis is the Integrated Transaction Cost Economics Model, and the focus is on implementation of company resources and capabilities in order to achieve optimal performance. The analysis is based on information of the Norwegian company Statoil ASA. The discussion concern; which organizational form is optimal ...

  14. Geriatric Hip Fractures and Inpatient Services: Predicting Hospital Charges Using the ASA Score

    OpenAIRE

    Thakore, Rachel V.; Young M. Lee; Vasanth Sathiyakumar; Obremskey, William T.; Sethi, Manish K.

    2014-01-01

    Purpose. To determine if the American Society of Anesthesiologist (ASA) score can be used to predict hospital charges for inpatient services. Materials and Methods. A retrospective chart review was conducted at a level I trauma center on 547 patients over the age of 60 who presented with a hip fracture and required operative fixation. Hospital charges associated with inpatient and postoperative services were organized within six categories of care. Analysis of variance and a linear regression...

  15. The Curious Case of ASAS J174600-2321.3: an Eclipsing Symbiotic Nova in Outburst?

    CERN Document Server

    Huemmerich, Stefan; Tisserand, Patrick; Bernhard, Klaus

    2015-01-01

    The star ASAS J174600-2321.3 was found to exhibit peculiar photometric variability (conspicuous brightening of about 4 magnitudes (V), fast luminosity declines, intrinsic pulsations). It was rejected as an RCB candidate in recent investigations on spectroscopic grounds. We have collected and present all available data from public sky surveys, photometric catalogues, and the literature. From an analysis of these data, we have identified ASAS J174600-2321.3 as a long-period eclipsing binary (Porb = 1011.5 days). The primary star, which is probably a white dwarf, is currently in outburst and exhibits the spectral characteristics of a reddened, early F-type supergiant; the secondary star is a giant of spectral type late M. We discuss the possible origin of the observed brightening, which is related to the primary component. ASAS J174600-2321.3 is most certainly an eclipsing symbiotic binary - probably a symbiotic nova of GCVS type NC - that is currently in outburst. However, further photometric and spectroscopic ...

  16. The Pre-Main-Sequence Eclipsing Binary ASAS J052821+0338.5

    CERN Document Server

    Stempels, H C; Stassun, K G; Holtzman, J; Dunstone, N; Glowienka, L; Frandsen, S

    2008-01-01

    In this paper we present the first results of a detailed spectroscopic and photometric analysis of the V = 11.7m eclipsing binary ASAS J052821+0338.5. With the FIES spectrograph at the Nordic Optical Telescope we have obtained a series of high-resolution spectra (R=47000) covering the entire orbit of the system. In addition we obtained simultaneous broadband photometry from three small aperture telescopes. From these spectroscopic and photometric data we have derived the system's orbital parameters and determined the fundamental stellar parameters of the two components. Our results indicate that ASAS J052821+0338.5 is a K1/K3 pre-main-sequence eclipsing binary, with component masses of 1.38 M_sun and 1.33 M_sun and a period of 3.87 days, located at a distance of 280 +/- 30 pc. The kinematics, physical location and the evolutionary status of the two stars suggest that ASAS J052821+0338.5 is a member of the approximately 11 Myr old Orion OB1a subassociation. The systems also exhibits smooth 0.15m out-of-eclipse...

  17. Human brucellosis mimicking axial spondyloarthritis: a challenge for rheumatologists when applying the 2009 ASAS criteria.

    Science.gov (United States)

    Ye, Cong; Shen, Gui-Fen; Li, Shou-Xin; Dong, Ling-Li; Yu, Yi-Kai; Tu, Wei; Zhu, Ying-Zi; Hu, Shao-Xian

    2016-06-01

    Although the development of the 2009 SpA classification criteria by Assessment of SpondyloArthritis international Society (ASAS) represents an important step towards a better definition of the early disease stage particularly in axial spondyloarthritis (axSpA), the specificity of the criteria has been criticized these days. As the commonest zoonotic infection worldwide, human brucellosis can mimic a large number of diseases, including SpA. This study was performed to determine the frequency of rheumatologic manifestations in patients with brucellosis and the chance of misdiagnosing them as having axSpA in central China. The results showed that clinical manifestations of axSpA could be observed in brucellosis. Over half of patients had back pain, and one fifth of the patients with back pain were less than 45 years old at onset and had the symptom for more than 3 months. Two young males were falsely classified as suffering from axSpA according to the ASAS criteria, and one with MRI proved sacroiliitis was once given Etanercept for treatment. Therefore, differential diagnosis including human brucellosis should always be kept in mind when applying the ASAS criteria, even in traditionally non-endemic areas. PMID:27376805

  18. Dose-Related Effects of Acetylsalicylic acid (ASA) on Gamma Radiation-Induced Teratogenicity in Pregnant Albino Rats

    International Nuclear Information System (INIS)

    Reviews of acetylsalicylic acid (ASA), a widely used nonsteroidal anti- inflammatory drug, has consistently suggested a possible association between prenatal ASA ingestion and adverse effects in the pregnant mothers and their developing fetuses. The objective of the current study was to comprehensively define the effect of relatively low and high doses of ASA (25 mg/kg body wt. and 200 mg/kg body wt. respectively) on gestating rats and their possible impact on the irradiated ones. Therefore 36 pregnant rats were randomly divided into 6 equal groups. Three rat groups were daily orally gavaged from the 7th to the 18th gestational days with: distilled water (Group 1), 25 mg/kg body wt. ASA (Group 2) and 200 mg/kg body wt. ASA (Group 3). The other three groups similarly received the same previous treatments besides 2 Gy whole body gamma irradiation of each, to serve as: Group 4 (distilled water + irradiation), Group 5 (25 mg/kg body wt. ASA + irradiation) and Group 6 (200 mg/kg body wt. ASA + irradiation). All rat groups were sacrificed on the 20th day of pregnancy and the uterine contents were examined. The lower ASA dose (25 mg/kg body wt.) treated group (Group 2) displayed healthy mothers and fetuses whereas that of the higher dose (200 mg/kg body wt.) (Group 3) despite not showing significant maternal or fetal mortalities, yet the intrauterine contents presented fetal developmental disorders including stunted growth and resorption together with some head and limb anomalies including plagiocephaly, marked acampsia and acrocontracture. Meanwhile, results have unexpectedly shown a radioprotective role of the lower ASA dose (25 mg/kg. body wt.) (Group 5) to pregnant rats and their fetuses as inspected by its efficacy in retrieving the radiation induced maternal weight loss together with its noticeable ameliorating effects on the intrauterine lethality of the affected fetuses and their externally detected abnormalities in addition toits effectiveness in retaining some

  19. Reducing AsA leads to leaf lesion and defence response in knock-down of the AsA biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant.

    Science.gov (United States)

    Zhang, Chanjuan; Ouyang, Bo; Yang, Changxian; Zhang, Xiaohui; Liu, Hui; Zhang, Yuyang; Zhang, Junhong; Li, Hanxia; Ye, Zhibiao

    2013-01-01

    As a vital antioxidant, L-ascorbic acid (AsA) affects diverse biological processes in higher plants. Lack of AsA in cell impairs plant development. In the present study, we manipulated a gene of GDP-mannose pyrophosphorylase which catalyzes the conversion of D-mannose-1-P to GDP-D-mannose in AsA biosynthetic pathway and found out the phenotype alteration of tomato. In the tomato genome, there are four members of GMP gene family and they constitutively expressed in various tissues in distinct expression patterns. As expected, over-expression of SlGMP3 increased total AsA contents and enhanced the tolerance to oxidative stress in tomato. On the contrary, knock-down of SlGMP3 significantly decreased AsA contents below the threshold level and altered the phenotype of tomato plants with lesions and further senescence. Further analysis indicated the causes for this symptom could result from failing to instantly deplete the reactive oxygen species (ROS) as decline of free radical scavenging activity. More ROS accumulated in the leaves and then triggered expressions of defence-related genes and mimic symptom occurred on the leaves similar to hypersensitive responses against pathogens. Consequently, the photosynthesis of leaves was dramatically fallen. These results suggested the vital roles of AsA as an antioxidant in leaf function and defence response of tomato.

  20. Reducing AsA leads to leaf lesion and defence response in knock-down of the AsA biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant.

    Directory of Open Access Journals (Sweden)

    Chanjuan Zhang

    Full Text Available As a vital antioxidant, L-ascorbic acid (AsA affects diverse biological processes in higher plants. Lack of AsA in cell impairs plant development. In the present study, we manipulated a gene of GDP-mannose pyrophosphorylase which catalyzes the conversion of D-mannose-1-P to GDP-D-mannose in AsA biosynthetic pathway and found out the phenotype alteration of tomato. In the tomato genome, there are four members of GMP gene family and they constitutively expressed in various tissues in distinct expression patterns. As expected, over-expression of SlGMP3 increased total AsA contents and enhanced the tolerance to oxidative stress in tomato. On the contrary, knock-down of SlGMP3 significantly decreased AsA contents below the threshold level and altered the phenotype of tomato plants with lesions and further senescence. Further analysis indicated the causes for this symptom could result from failing to instantly deplete the reactive oxygen species (ROS as decline of free radical scavenging activity. More ROS accumulated in the leaves and then triggered expressions of defence-related genes and mimic symptom occurred on the leaves similar to hypersensitive responses against pathogens. Consequently, the photosynthesis of leaves was dramatically fallen. These results suggested the vital roles of AsA as an antioxidant in leaf function and defence response of tomato.

  1. Influence of pre-anaesthetic thoracic radiographs on ASA physical status classification and anaesthetic protocols in traumatized dogs and cats

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate if pre-anaesthetic thoracic radiographs contribute to the anaesthetic management of trauma patients by comparing American Society of Anesthesiologists Physical Status Classification (ASA grade) with and without information from thoracic radiography findings. Case records of 157 dogs and cats being anaesthetized with or without post-traumatic, pre-anaesthetic chest radiographs were retrospectively evaluated for clinical parameters, radiographic abnormalities and anaesthetic protocol. Animals were retrospectively assigned an ASA grade. ASA grades, clinical signs of respiratory abnormalities and anaesthesia protocols were compared between animals with and without chest radiographs. The group of animals without pre-anaesthetic radiographs was anaesthetized earlier after trauma and showed less respiratory abnormalities at presentation. The retrospectively evaluated ASA grade significantly increased with the information from thoracic radiography. Animals with a higher ASA grade were less frequently mechanically ventilated. Pre-anaesthetic radiographs may provide important information to assess the ASA grade in traumatized patients and may therefore influence the anesthesia protocol

  2. USING CATIONIC POLYMERS TO IMPROVE ALKENYL SUCCINIC ANHYDRIDE (ASA SIZING EFFICIENCY IN HIGH-YIELD PULP CONTAINING FURNISH

    Directory of Open Access Journals (Sweden)

    Qijie Chen,

    2012-07-01

    Full Text Available High-yield pulp (HYP such as bleached chemi-thermo-mechanical pulp (BCTMP from aspen wood, is now being used in the production of high-quality fine papers, and this is particularly true in China. In this study, the effect of using cationic polymers such as poly-aluminum chloride (PAC, polyethylenimine (PEI, cationic polyacrylamide (CPAM, and poly-(diallyldimethylammonium chloride (PDADMAC on Alkenyl Succinic Anhydride (ASA sizing efficiency in HYP-containing pulp furnish was investigated. The results showed that the addition of only ASA emulsion to the HYP-containing furnish, without any cationic additives, did not yield an appreciable degree of sizing in the paper sheet. PAC (or alum could improve the ASA sizing efficiency. PEI, PDADMAC, CPAM, and NaHCO3 all improved ASA sizing efficiency in the presence of PAC. The charge density of PEI was important for improving the ASA sizing performance. Also, the sequence of adding the cationic polymer affected the ASA sizing performance.

  3. A Nanometer Aerosol Size Analyzer (nASA) for Rapid Measurement of High-concentration Size Distributions

    International Nuclear Information System (INIS)

    We have developed a fast-response nanometer aerosol size analyzer (nASA) that is capable of scanning 30 size channels between 3 and 100 nm in a total time of 3 s. The analyzer includes a bipolar charger (Po210), an extended-length nanometer differential mobility analyzer (Nano-DMA), and an electrometer (TSI 3068). This combination of components provides particle size spectra at a scan rate of 0.1 s per channel free of uncertainties caused by response-time-induced smearing. The nASA thus offers a fast response for aerosol size distribution measurements in high-concentration conditions and also eliminates the need for applying a de-smearing algorithm to resulting data. In addition, because of its thermodynamically stable means of particle detection, the nASA is useful for applications requiring measurements over a broad range of sample pressures and temperatures. Indeed, experimental transfer functions determined for the extended-length Nano-DMA using the tandem differential mobility analyzer (TDMA) technique indicate the nASA provides good size resolution at pressures as low as 200 Torr. Also, as was demonstrated in tests to characterize the soot emissions from the J85-GE engine of a T-38 aircraft, the broad dynamic concentration range of the nASA makes it particularly suitable for studies of combustion or particle formation processes. Further details of the nASA performance as well as results from calibrations, laboratory tests and field applications are presented below

  4. Deriving albedo maps for HAPEX-Sahel from ASAS data using kernel-driven BRDF models

    Directory of Open Access Journals (Sweden)

    P. Lewis

    1999-01-01

    Full Text Available This paper describes the application and testing of a method for deriving spatial estimates of albedo from multi-angle remote sensing data. Linear kernel-driven models of surface bi-directional reflectance have been inverted against high spatial resolution multi-angular, multi- spectral airborne data of the principal cover types within the HAPEX-Sahel study site in Niger, West Africa. The airborne data are obtained from the NASA Airborne Solid-state Imaging Spectrometer (ASAS instrument, flown in Niger in September and October 1992. The maps of model parameters produced are used to estimate integrated reflectance properties related to spectral albedo. Broadband albedo has been estimated from this by weighting the spectral albedo for each pixel within the map as a function of the appropriate spectral solar irradiance and proportion of direct and diffuse illumination. Partial validation of the results was performed by comparing ASAS reflectance and derived directional-hemispherical reflectance with simulations of a millet canopy made with a complex geometric canopy reflectance model, the Botanical Plant Modelling System (BPMS. Both were found to agree well in magnitude. Broadband albedo values derived from the ASAS data were compared with ground-based (point sample albedo measurements and found to agree extremely well. These results indicate that the linear kernel-driven modelling approach, which is to be used operationally to produce global 16 day, 1 km albedo maps from forthcoming NASA Earth Observing System spaceborne data, is both sound and practical for the estimation of angle-integrated spectral reflectance quantities related to albedo. Results for broadband albedo are dependent on spectral sampling and on obtaining the correct spectral weigthings.

  5. Fragment o dimenzijah emocije, "mathesisa" in časa v čisto glasbenem

    OpenAIRE

    Popović Mlađenović, Tijana

    2015-01-01

    V dialogu iz Kaj je glasba? Carla Dahlhausa in Hansa Heinricha Eggebrecht je glasba opredeljena kot "matematizirana emocija" ali "emocionalizirani 'mathesis'". Kot poudarja Marija Bergamo, gre za način izpostavljanja enakosti, neizogibnosti konstituiranja glasbe kot emotivno in racionalne organizacije v dimenziji časa. Marija Bergamo nenehno išče tista določila glasbenega dela kot "avtonomnega estetskega dejstva", ki temeljijo in katerih resnično bistvo leži "znotraj narave in bistva glasbe s...

  6. Discovery of Bright Galactic R Coronae Borealis and DY Persei Variables: Rare Gems Mined from ASAS

    CERN Document Server

    Miller, A A; Bloom, J S; Cenko, S B; Silverman, J M; Starr, D L; Stassun, K G

    2012-01-01

    We present the results of a machine-learning (ML) based search for new R Coronae Borealis (RCB) stars and DY Persei-like stars (DYPers) in the Galaxy using cataloged light curves obtained by the All-Sky Automated Survey (ASAS). RCB stars - a rare class of hydrogen-deficient carbon-rich supergiants - are of great interest owing to the insights they can provide on the late stages of stellar evolution. DYPers are possibly the low-temperature, low-luminosity analogs to the RCB phenomenon, though additional examples are needed to fully establish this connection. While RCB stars and DYPers are traditionally identified by epochs of extreme dimming that occur without regularity, the ML search framework more fully captures the richness and diversity of their photometric behavior. We demonstrate that our ML method recovers ASAS candidates that would have been missed by traditional search methods employing hard cuts on amplitude and periodicity. Our search yields 13 candidates that we consider likely RCB stars/DYPers: n...

  7. The ongoing pursuit of R Coronae Borealis stars: ASAS-3 survey strikes again

    CERN Document Server

    Tisserand, P; Welch, D L; Pilecki, B; Wyrzykowski, L; Kilkenny, D

    2012-01-01

    R Coronae Borealis stars (RCBs) are rare, hydrogen-deficient, carbon-rich supergiant variable stars that are likely the evolved merger products of pairs of CO and He white dwarfs. Only 55 RCB stars are known in our galaxy and their distribution on the sky is weighted heavily by microlensing survey field positions. A less-biased wide-area survey would provide the ability to test competing evolutionary scenarios, understand the population or populations that produce RCBs and constraint their formation rate. The ASAS-3 survey monitored the sky south of declination +28 deg since 2000 to a limiting magnitude of V=14. We searched ASAS-3 for RCB variables using a number of different methods to ensure that the probability of RCB detection was as high as possible and to reduce selection biases based on luminosity, temperature, dust production activity and shell brightness. Candidates whose light curves were visually inspected were pre-selected based on their infrared excesses due to warm dust in their circumstellar sh...

  8. A new bright eclipsing hot subdwarf binary from the ASAS and SuperWASP surveys

    CERN Document Server

    Schaffenroth, V; Drechsel, H; Heber, U; Wils, P; Oestensen, R H; Maxted, P F L; di Scala, G

    2013-01-01

    We report the discovery of a bright (V=11.6 mag) eclipsing hot subdwarf binary of spectral type B with a late main sequence companion from the All Sky Automated Survey (ASAS 102322-3737.0). Such systems are called HW Vir stars after the prototype. The lightcurve shows a grazing eclipse and a strong reflection effect. An orbital period of P=0.13927 d, an inclination of i=65.86{\\deg}, a mass ratio q=0.34, a radial velocity semiamplitude K_1=81.0 kms^-1, and other parameters are derived from a combined spectroscopic and photometric analysis. The short period can only be explained by a common envelope origin of the system. The atmospheric parameters (T_eff=28400 K, log g=5.60) are consistent with a core helium-burning star located on the extreme horizontal branch. In agreement with that we derived the most likely sdB mass to be M_sdB=0.46M_sun, close to the canonical mass of such objects. The companion is a late M-dwarf with a mass of M_comp=0.16 M_sun. ASAS 102322-3737.0 is the third brightest of only 12 known H...

  9. [Effects of exogenous AsA and GSH on the growth of Dianthus chinensis seedlings exposed to Cd].

    Science.gov (United States)

    Ding, Ji-Jun; Liu, Shi-Liang; Pan, Yuan-Zhi; Li, Li

    2014-02-01

    A pot experiment was carried out under greenhouse condition to investigate the effects of different concentrations (0, 20, 40, 60, 80 and 100 mg x L(-1)) of exogenous AsA, GSH on Dianthus chinensis seedlings which were stressed by 50 mg x kg(-1) Cd in the soil. The results indicated that 50 mg x kg(-1) of Cd significantly inhibited the growth of D. chinensis seedlings. An appropriate concentration of exogenous AsA significantly improved the biomass, plant height, tiller number, GAT and APX activities, and AsA and GSH contents. However, with the increase of exogenous AsA concentration, the ameliorating effect decreased and prooxidant effect occurred. Exogenous GSH could replenish the non-enzymatic antioxidants of D. chinensis seedlings, but the changes of antioxidant enzyme activities were relatively slight. The main mechanisms of GSH to alleviate Cd toxicity might be promoting root PCs synthesis, thereby reducing the Cd concentration in the seedlings. Both 35-45 mg x L(-1) exogenous AsA and 55-65 mg x L(-1) exogenous GSH could alleviate the Cd toxicity on D. chinensis seedlings, and the former was superior to the latter.

  10. ASAS J083241+2332.4: A NEW EXTREME LOW MASS RATIO OVERCONTACT BINARY SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Sriram, K.; Malu, S.; Vivekananda Rao, P. [Department of Astronomy, Osmania University, Hyderabad 500007 (India); Choi, C. S., E-mail: astrosriram@yahoo.co.in [Korea Astronomy and Space Science Institute, Daejeon 34055 (Korea, Republic of)

    2016-03-15

    We present the R- and V-band CCD photometry and Hα line studies of an overcontact binary ASAS J083241+2332.4. The light curves exhibit totality along with a trace of the O’Connell effect. The photometric solution indicates that this system falls into the category of extreme low-mass ratio overcontact binaries with a mass ratio, q ∼ 0.06. Although a trace of the O’ Connell effect is observed, constancy of the Hα line along various phases suggest that a relatively higher magnetic activity is needed for it to show a prominent fill-in effect. The study of O–C variations reveals that the period of the binary shows a secular increase at the rate of dP/dt ∼ 0.0765 s years{sup −1}, which is superimposed by a low, but significant, sinusoidal modulation with a period of ∼8.25 years. Assuming that the sinusoidal variation is due to the presence of a third body, orbital elements have been derived. There exist three other similar systems, SX Crv, V857 Her, and E53, which have extremely low mass ratios and we conclude that ASAS J083241+2332.4 resembles SX Crv in many respects. Theoretical studies indicate that at a critical mass ratio range, q{sub critical} = 0.07–0.09, overcontact binaries should merge and form a fast rotating star, but it has been suggested that q{sub critical} can continue to fall up to 0.05 depending on the primary's mass and structure. Moreover, the obtained fill-out factors (50%–70%) indicate that mass loss is considerable and hydrodynamical simulations advocate that mass loss from L{sub 2} is mandatory for a successful merging process. Comprehensively, the results indicate that ASAS J083241+2332.4 is at a stage of merger. The pivotal role played by the subtle nature of the derived mass ratio in forming a rapidly rotating star has been discussed.

  11. Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats.

    Science.gov (United States)

    Galunska, B; Marazova, K; Tankova, T; Popov, A; Frangov, P; Krushkov, I; Di Massa, A

    2002-08-01

    We have studied the effect of paracetamol and its pro-drug propacetamol on gastric mucosal damage induced by acetylsalicylic acid (ASA) and its possible relation to changes in gastric lipid peroxidation status in rats. Paracetamol or propacetamol were administered intragastrically 1h before ASA (300 mg kg(-1)) in the following equivalent doses: 62.5, 125.0 and 250.0 mg kg(-1) or 125.0, 250.0 and 500.0 mg kg(-1), respectively. The effects of the tested agents were compared to that of prostaglandin E2 (PGE2) 15, 30 and 60 mg kg(-1). Gastric ulcer formation was estimated morphometrically 4h after ASA administration. Malondialdehyde (MDA), glutathione (reduced, GSH, and oxidized, GSSG) and uric acid (UA) were determined in gastric mucosa and blood plasma and used as biochemical markers of the oxidative status. The results showed that paracetamol (250, 125, 62.5 mg kg(-1)) and propacetamol (500, 250, 125 mg kg(-1)) diminished the area of ASA-induced gastric lesions. The effect of propacetamol was more pronounced than that of paracetamol and similar to that of PGE2. Gastric MDA increased 3-fold in the ASA-group. The tested agents reduced it by a range of 30-70%. In all pretreated groups gastric glutathione and UA levels were found higher than that of control group and lower than that of ASA-group. Paracetamol and propacetamol, as well as PGE2, diminished the lipid peroxidation in plasma to a lesser extent than in gastric mucosa, but maintained elevated levels of the selective plasma antioxidant UA. These results show that the ASA-induced gastric mucosal damage is accompanied by the development of oxidative stress, evidenced by the accumulation of MDA, and concomitant initial activation of cell antioxidant defences. As paracetamol and propacetamol tend to decrease gastric lesions caused by ASA and alter gastric mucosal MDA, glutathione and UA values in a favorable manner, it could be suggested that their effects on the gastric mucosa could be related to interference with

  12. ASAS-SN 13cl : A Newly-Discovered Cataclysmic Binary with an Anomalously Warm Secondary

    CERN Document Server

    Thorstensen, John R

    2015-01-01

    The spectrum of the recently discovered cataclysmic variable star (CV) ASAS-SN 13cl shows that a secondary star with spectral type K4 (+- 2 subclasses) contributes roughly half the optical light. The radial velocities of the secondary are modulated on an orbital period P_orb = 4.86 hr with a velocity semiamplitude K = 246 +- 9 km/s, and the light curve shows ellipsoidal variations and an apparent grazing eclipse. At this orbital period, the secondary stars in most CVs are substantially cooler, with spectral types near M3. ASN-13cl therefore joins the small group of CVs with anomalously warm secondary stars, which apparently form when the onset of mass transfer occurs after the secondary has undergone significant nuclear evolution.

  13. New Photometrically Variable Magnetic Chemically Peculiar Stars in the ASAS-3 Archive

    Science.gov (United States)

    Hümmerich, Stefan; Paunzen, Ernst; Bernhard, Klaus

    2016-10-01

    The magnetic Ap or CP2 stars are natural atomic and magnetic laboratories. Strictly periodic changes are observed in the spectra and brightness of these stars, which allow the derivation of rotational periods. Related to this group of objects are the He-weak (CP4) and He-rich stars, some of which also undergo brightness changes due to rotational modulation. Increasing the sample size of known rotational periods among CP2/4 stars is important and will contribute to our understanding of these objects and their evolution in time. We have compiled an extensive target list of CP2/4 stars from the General Catalog of Ap, HgMn, and Am stars, including several early-type (spectral types B/A) variables of undetermined type from the International Variable Star Index. We investigated our sample stars using publicly available observations from the ASAS-3 archive. Our previous efforts in this respect led to the discovery of 323 variable stars. Using a refined analysis approach, we were able to identify another 360 stars exhibiting photometric variability in ASAS-3 data. Summary data, folded light curves and, if available, information from the literature are presented for our final sample, which is composed of 334 bona-fide {α }2 Canum Venaticorum (ACV) variables, 23 ACV candidates, and 3 eclipsing binary systems. Interesting and unusual objects are discussed in detail. In particular, we call attention to HD 66051 (V414 Pup), which is an eclipsing binary system showing obvious rotational modulation of the light curve due to the presence of an ACV variable in the system.

  14. ASA conference on radiation and health: Health effects of electric and magnetic fields: Statistical support for research strategies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1990-05-01

    This report is a collection of papers documenting presentations made at the VIII ASA (American Statistical Association) Conference on Radiation and Health entitled Health Effects of Electric and Magnetic Fields: Statistical Support for Research Strategies. Individual papers are abstracted and indexed for the database.

  15. Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease

    NARCIS (Netherlands)

    Heap, Graham A.; So, Kenji; Weedon, Mike; Edney, Naomi; Bewshea, Claire; Singh, Abhey; Annese, Vito; Beckly, John; Buurman, Dorien; Chaudhary, Rakesh; Cole, Andrew T.; Cooper, Sheldon C.; Creed, Tom; Cummings, Fraser; de Boer, Nanne K.; D'Inca, Renata; D'Souza, Richard; Daneshmend, Tawfique K.; Delaney, Michael; Dhar, Anjan; Direkze, Natalie; Dunckley, Paul; Gaya, Daniel R.; Gearry, Richard; Gore, Steve; Halfvarson, Jonas; Hart, Ailsa; Hawkey, Chris J.; Hoentjen, Frank; Iqbal, Tariq; Irving, Peter; Lal, Simon; Lawrence, Ian; Lees, Charlie W.; Lewis, Steve; Lockett, Melanie; Mann, Stephen; Mansfield, John; Mowat, Craig; Mulgrew, Chris J.; Müller, Frank; Murray, Charles; Oram, Richard; Orchard, Tim; Parkes, Miles; Phillips, Rosemary; Pollok, Richard; Radford-Smith, Graham; Sebastian, Shaji; Sen, Sandip; Shirazi, Tarek; Silverberg, Mark; Solomon, Laurie; Sturniolo, Giacomo C.; Thomas, Mark; Tremelling, Mark; Tsianos, Epameinondas V.; Watts, David; Weaver, Sean; Weersma, Rinse K.; Wesley, Emma; Holden, Arthur; Ahmad, Tariq

    2016-01-01

    Background and Aims: Nephrotoxicity is a rare idiosyncratic reaction to 5-aminosalicylate (5-ASA) therapies. The aims of this study were to describe the clinical features of this complication and identify clinically useful genetic markers so that these drugs can be avoided or so that monitoring can

  16. Association between oral 5-ASA adherence and health care utilization and costs among patients with active ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Mitra Debanjali

    2012-09-01

    Full Text Available Abstract Background Observational cohort study to assess the association between adherence to oral 5-aminosalicylates (5-ASAs and all-cause costs and health care utilization among patients with active ulcerative colitis (UC in the United States. Methods Retrospective analysis of insurance claims from June 1997 to August 2006 in the LifeLink Database. Patient criteria: aged 18 or older with one or more claim(s between June 1997 and August 2005 for a UC diagnosis and at least one oral 5-ASA prescription on or after the first observed UC diagnosis; continuous enrollment for at least 6 months prior to and 12 months following 5-ASA initiation (index date. As a proxy for active disease, patients needed to have at least two UC-specific non-pharmacy claims, at least 30 days of 5-ASA treatment and at least one corticosteroid prescription within the 12-month post-index period. Cumulative exposure to oral 5-ASAs over the 12-month period was calculated using the medication possession ratio (MPR. Patients with an MPR of at least 0.80 were classified as adherent. All-cause medical and pharmacy resource utilization and costs were computed over the 12-month post-index period and compared between adherent and nonadherent patients. Results 1,693 UC patients met study inclusion criteria: 72% were nonadherent to 5-ASA treatment (n = 1,217 and 28% were adherent (n = 476 in the 12-month study period. Compared with nonadherent patients, adherent patients had 31% fewer hospitalizations (P = 0.0025 and 34% fewer emergency department admissions (P = 0.0016. Adherent patients had 25% more pharmacy prescriptions overall (P P P = 0.0002. After adjusting for covariates, total all-cause costs were 29% higher for nonadherent patients than for adherent patients (mean [95% confidence interval]: $13,465 [$13,094, $13,835] vs $17,339 [$17,033, $17,645]. Conclusions Approximately three-quarters of patients with active UC were not adherent with their

  17. Pharmaceuticals and other organic chemicals in selected north-central and northwestern Arkansas streams

    Science.gov (United States)

    Haggard, B.E.; Galloway, J.M.; Green, W.R.; Meyer, M.T.

    2006-01-01

    Recently, our attention has focused on the low level detection of many antibiotics, pharmaceuticals, and other organic chemicals in water resources. The limited studies available suggest that urban or rural streams receiving wastewater effluent are more susceptible to contamination. The purpose of this study was to evaluate the occurrence of antibiotics, pharmaceuticals, and other organic chemicals at 18 sites on seven selected streams in Arkansas, USA, during March, April, and August 2004. Water samples were collected upstream and downstream from the influence of effluent discharges in northwestern Arkansas and at one site on a relatively undeveloped stream in north-central Arkansas. At least one antibiotic, pharmaceutical, or other organic chemical was detected at all sites, except at Spavinaw Creek near Mayesville, Arkansas. The greatest number of detections was observed at Mud Creek downstream from an effluent discharge, including 31 pharmaceuticals and other organic chemicals. The detection of these chemicals occurred in higher frequency at sites downstream from effluent discharges compared to those sites upstream from effluent discharges; total chemical concentration was also greater downstream. Wastewater effluent discharge increased the concentrations of detergent metabolites, fire retardants, fragrances and flavors, and steroids in these streams. Antibiotics and associated degradation products were only found at two streams downstream from effluent discharges. Overall, 42 of the 108 chemicals targeted in this study were found in water samples from at least one site, and the most frequently detected organic chemicals included caffeine, phenol, para-cresol, and acetyl hexamethyl tetrahydro naphthalene (AHTN). ?? ASA, CSSA, SSSA.

  18. A search for photometric variability in magnetic chemically peculiar stars using ASAS-3 data

    Science.gov (United States)

    Bernhard, K.; Hümmerich, S.; Otero, S.; Paunzen, E.

    2015-09-01

    Context. The (magnetic) chemically peculiar (CP) stars of the upper main sequence are well-suited laboratories for investigating the influence of magnetic fields on the stellar surface because they produce abundance inhomogeneities (spots), which results in photometric variability that is explained in terms of the oblique rotator model. CP stars exhibiting this phenomenon are normally classified as α2 Canum Venaticorum (ACV) variables. It is important to increase the sample of known rotational periods among CP stars by discovering new ACV variables. An increased sample size will contribute to the understanding of the CP stars' evolution in time. Aims: We aim at discovering new ACV variables in the public data of the third phase of the All Sky Automated Survey (ASAS-3). Furthermore, by analysis of the available photometric data, we intend to derive rotational periods of the stars. Methods: The ASAS-3 data were cross-correlated with the Catalogue of Ap, HgMn, and Am stars in order to analyse the light curves of bona fide CP and related stars. The light curves were downloaded and cleaned of outliers and data points with a flag indicating bad quality. Promising candidates showing a larger scatter than observed for constant stars in the corresponding magnitude range were searched for periodic signals using a standard Fourier technique. Objects exhibiting periodic signals well above the noise level were considered and visually inspected, whereas borderline cases were rejected. Results: In total, we found 323 variables, from which 246 are reported here for the first time, and 77 were probably wrongly classified before. The observed variability pattern of most stars is in accordance with an ACV classification. For some cases, it is difficult to distinguish between the light curves of double-waved ACVs and the variability induced by orbital motion (ellipsoidal variables/eclipsing variables), especially for objects exhibiting very small amplitudes and/or significant scatter

  19. Making a Theist out of Darwin: Asa Gray's Post-Darwinian Natural Theology

    Science.gov (United States)

    Russell Hunter, T.

    2012-07-01

    In March of 1860 the eminent Harvard Botanist and orthodox Christian Asa Gray began promoting the Origin of Species in hopes of securing a fair examination of Darwin's evolutionary theory among theistic naturalists. To this end, Gray sought to demonstrate that Darwin had not written atheistically and that his theory of evolution by natural selection had not presented any new scientific or theological difficulties for traditional Christian belief. From his personal correspondence with the author of the Origin, Gray well knew that Darwin did not affirm God's "particular" design of nature but conceded to the possibility that evolution proceeded according to "designed laws." From this concession, Gray attempted to develop a post-Darwinian natural theology which encouraged theistic naturalists to view God's design of nature through the evolutionary process in a manner similar to the way in which they viewed God's Providential interaction with human history. Indeed, securing a fair reading of the Origin was not Gray's sole aim as a promoter of Darwinian ideas. In Darwin's theory of natural selection, Gray believed he had discovered the means by which a more robust natural theological conception of the living and evolving natural world could be developed. In this paper I outline Gray's efforts to produce and popularize a theistic interpretation of Darwinian theory in order to correct various misconceptions concerning Gray's natural theological views and their role in the Darwinian Revolution.

  20. VARIABILITY OF LUMINOUS STARS IN THE LARGE MAGELLANIC CLOUD USING 10 YEARS OF ASAS DATA

    International Nuclear Information System (INIS)

    Motivated by the detection of a recent outburst of the massive luminous blue variable LMC-R71, which reached an absolute magnitude MV = -9.3 mag, we undertook a systematic study of the optical variability of 1268 massive stars in the Large Magellanic Cloud, using a recent catalog by Bonanos et al. as the input. The ASAS All Star Catalog provided well-sampled light curves of these bright stars spanning 10 years. Combining the two catalogs resulted in 599 matches, on which we performed a variability search. We identified 117 variable stars, 38 of which were not known before, despite their brightness and large amplitude of variation. We found 13 periodic stars that we classify as eclipsing binary (EB) stars, 8 of which are newly discovered bright massive EBs composed of OB-type stars. The remaining 104 variables are either semi- or non-periodic, the majority (85) being red supergiants (RSGs). Most (26) of the newly discovered variables in this category are also RSGs with only three B and four O stars.

  1. PENERAPAN ASAS UMUM PEMERINTAHAN YANG BAIK DALAM SISTEM PELAYANAN PERIZINAN SATU PINTU

    Directory of Open Access Journals (Sweden)

    Dwi Haryati

    2012-10-01

    Full Text Available This study will discuss the implementation of General Principles of Good Governance (AUPB in the One Stop Licensing System in the city of Yogyakarta. Some things that would be an important consideration in this study were changes to Local Government Law No. 22 of 1999 as Law No. 32 of 2004 and its consequence, the issuance of Government Regulation No. 84 of 2000 governing the organization’s guidelines in the area of technical authority in issuing permits and Ministerial Decree No. PAN 63/KEP/M.PAN/7/2003 On Implementation Guidelines for Public Service and Administrative Reform Decree No. 26/KEP/M.PAN/2/2004 About Help Technical Transparency and Accountability. Penelitian ini akan membahas penerapan Asas Umum Pemerintahan yang Baik (AUPB dalam Sistem Perijinan Satu Pintu di Kota Yogyakarta. Beberapa hal yang akan menjadi pertimbangan penting dalam penelitian ini adalah Perubahan UU Otonomi Daerah Nomor 22 Tahun 1999 menjadi UU Nomor 32 Tahun 2004 beserta konsekuensinya. Penerbitan Peraturan Pemerintah Nomor 84 Tahun 2000 yang mengatur tentang pedoman organisasi perangkat daerah dalam kewenangan teknisnya mengeluarkan ijin di daerah serta Kepmen PAN Nomor 63/KEP/M.PAN/7/2003 tentang Pedoman Penyelenggaraan Pelayanan Publik dan Keputusan Menteri Pendayagunaan Aparatur Negara Nomor 26/KEP/M. PAN/2/2004 tentang Petunjuk Teknis Transparansi dan Akuntabilitas.

  2. VizieR Online Data Catalog: ASAS 101538-5933.1 BV light curves (Berdnikov, 2013)

    Science.gov (United States)

    Berdnikov, L. N.

    2013-04-01

    In the plate collection of the Harvard College Observatory, we have obtained 528 photographic magnitude estimates for the recently discovered long-period classical Cepheid ASAS 101538-5933.1 (P=51.4-days). Together with the published photoelectric and CCD observations, our data have allowed us to construct an O-C diagram spanning a time interval of 120 years. The O-C diagram has the shape of a parabola, which has made it possible to determine for the first time the quadratic light elements and to calculate the rate of evolutionary increase in the period, dP/dt=51.8(+/-4.8)s/yr or (dP/dt)/P=7.3(+/-0.7)s, in agreement with the results of theoretical calculations for the third crossing of the instability strip. The available data reduced by the method of Eddington and Plakidis reveal small random period fluctuations that do not distort the evolutionary trend in the O-C residuals. (1 data file).

  3. A search for photometric variability in magnetic chemically peculiar stars using ASAS-3 data

    CERN Document Server

    Bernhard, K; Otero, S; Paunzen, E

    2015-01-01

    The (magnetic) chemically peculiar (CP) stars of the upper main sequence are well-suited laboratories for investigating the influence of magnetic fields on the stellar surface because they produce abundance inhomogeneities (spots), which results in photometric variability that is explained in terms of the oblique rotator model. CP stars exhibiting this phenomenon are normally classified as alpha2 Canum Venaticorum (ACV) variables. It is important to increase the sample of known rotational periods among CP stars by discovering new ACV variables. The ASAS-3 data were cross-correlated with the Catalogue of Ap, HgMn, and Am stars in order to analyse the light curves of bona fide CP and related stars. The light curves were downloaded and cleaned of outliers and data points with a flag indicating bad quality. Promising candidates showing a larger scatter than observed for constant stars in the corresponding magnitude range were searched for periodic signals using a standard Fourier technique. In total, we found 323...

  4. Synthesis and hydrocracking performance of Y/ASA composite%Y/ASA复合材料的制备及加氢裂化性能

    Institute of Scientific and Technical Information of China (English)

    孟庆磊; 刘百军; 盖有东; 何琳琳

    2012-01-01

    采用原位包覆技术制备了无定形硅铝(ASA)包覆Y型分子筛的Y/ASA复合材料.分别以Y/ASA复合材料和工业Y分子筛与ASA的机械混合材料Y-ASA为载体,Ni-W为活性组分,制备了两种负载型催化剂,并考察了两种催化剂的加氢裂化性能,通过XRD、SEM、吸附吡啶的原位红外光谱和N2吸附-脱附对载体和催化剂进行了表征.结果表明,Y/ASA载体和Ni-W/Y/ASA的总酸量较低,但强酸量和强弱酸比例均高于Y-ASA和Ni-W/Y-ASA,Y/ASA载体和Ni-W/Y/ASA催化剂拥有更大的介孔比表面积、孔容及平均孔径.正癸烷的加氢裂化反应结果表明,Ni-W/Y/ASA催化剂上正癸烷的转化率和中间组分(C5-9)收率比Ni-W/Y-ASA催化剂分别高7.6%和12.4%.%In-situ covering technology was used to prepare the Y/ASA composite material in which Y zeolite was covered around with amorphous silica-alumina ( ASA). Two kinds of supported Ni-W catalysts for hydrocracking of decane were prepared using Y/ASA and Y-ASA as supports, respectively. Y-ASA was a kind of mechanical mixture of industrial Y zeolite and ASA. The supports and catalysts were characterized by X-ray powder diffraction, scanning electron microscopy, infrared spectroscopy of pyridine adsorption and N2 adsorption-desorption. The results showed that, while there were less total acid sites on Y/ASA and Ni-W/Y/ ASA, there were more strong acid sites. The ratios of strong acid sites to weak acid sites of Y/ASA and Ni-W/ Y/ASA were higher than those of Y-ASA and Ni-W/Y-ASA. The average pore diameter, mesopore surface area and pore volume of Y/ASA and Ni-W/Y/ASA were larger than those of the comparative samples, respectively. The hydrocracking of decane over the Ni-W/Y/ASA catalyst revealed that the conversion and yield of middle-component (C5 -9) were improved by 7.6 % and 12.4 % , respectively, compared with that over Ni-W/Y-ASA catalyst.

  5. Hacia la búsqueda sistemática de estrellas variables en asociaciones estelares: escarbando VSX y ASAS

    Science.gov (United States)

    Jaque Arancibia, M.; González, J. F.; Barbá, R. H.; Flores, M. G.; Veramendi, M. E.

    2016-08-01

    We present an application for period determination and automatic classification of light curves for eclipsing binaries. In this case, we have correlated the list of eclipsing binary stars from the international Variable Star indeX (VSX) data base, with the All-Sky Automated Survey (ASAS) and SIMBAD databases. As a result, we have obtained nearly 23000 light curves for stars with stellar magnitudes between 7 and 14. About 40 of these stars had not been previously detected by the automatic classification software of the ASAS project, which is motivating for finding new eclipsing binary stars. We show an overall statistics about light curves parameters for the 15000 stars of our sample, among which almost 10000 still lack detailed observational studies (less than four bibliographic entries).

  6. Orbital and physical parameters of eclipsing binaries from the ASAS catalogue -- IX. Spotted pairs with red giants

    CERN Document Server

    Ratajczak, M; Konacki, M; Smith, A M S; Kozłowski, S K; Espinoza, N; Jordán, A; Brahm, R; Hempel, M; Anderson, D R; Hellier, C

    2016-01-01

    We present spectroscopic and photometric solutions for three spotted systems with red giant components. Absolute physical and orbital parameters for these double-lined detached eclipsing binary stars are presented for the first time. These were derived from the V-, and I-band ASAS and WASP photometry, and new radial velocities calculated from high quality optical spectra we obtained with a wide range of spectrographs and using the two-dimensional cross-correlation technique (TODCOR). All of the investigated systems (ASAS J184949-1518.7, BQ Aqr, and V1207 Cen) show the differential evolutionary phase of their components consisting of a main sequence star or a subgiant and a red giant, and thus constitute very informative objects in terms of testing stellar evolution models. Additionally, the systems show significant chromospheric activity of both components. They can be also classified as classical RS CVn-type stars. Besides the standard analysis of radial velocities and photometry, we applied spectral disenta...

  7. Advanced Steganography Algorithm Using Randomized Intermediate QR Host Embedded With Any Encrypted Secret Message: ASA_QR Algorithm

    OpenAIRE

    Somdip Dey; Kalyan Mondal; Joyshree Nath; Asoke Nath

    2012-01-01

    Due to tremendous growth in communication technology, now it is a real problem / challenge to send some confidential data / information through communication network. For this reason, Nath et al. developed several information security systems, combining cryptography and steganography together, and the present method, ASA_QR, is also one of them. In the present paper, the authors present a new steganography algorithm to hide any small encrypted secret message inside QR CodeTM , which is then ...

  8. Orbital and physical parameters of eclipsing binaries from the ASAS catalogue -- IX. Spotted pairs with red giants

    OpenAIRE

    Ratajczak, M.; Hełminiak, K. G.; Konacki, M.; Smith, A.M.S.; Kozłowski, S. K.; Espinoza, N.; Jordán, A.; Brahm, R.; Hempel, M; Anderson, D R; Hellier, C.

    2016-01-01

    We present spectroscopic and photometric solutions for three spotted systems with red giant components. Absolute physical and orbital parameters for these double-lined detached eclipsing binary stars are presented for the first time. These were derived from the V-, and I-band ASAS and WASP photometry, and new radial velocities calculated from high quality optical spectra we obtained with a wide range of spectrographs and using the two-dimensional cross-correlation technique (TODCOR). All of t...

  9. Photometric study and preliminary elements of the low-mass ratio W UMa system ASAS 021209+2708.3

    Institute of Scientific and Technical Information of China (English)

    Francesco Acerbi; Carlo Barani; Massimiliano Martignoni

    2011-01-01

    We present CCD B and V light curves, obtained in the year 2006, and a photometric solution of the Iow-mass ratio contact binary ASAS 021209+2708.3.With our data we were able to determine six new times of minimum light and refine the orbital period of the system to 0.3181963 days. The light curves are analyzed using the 2003 version of the Wilson-Devinney program and the analysis was performed with and without adding a spot on the surface of one star because the light curves appear to exhibit a typical O'Connell effect, with Maximum I brighter than Maximum 11. The results show that ASAS 021209+2708.3 may be classified as an A-subtype W Ursae Majoris system with a small mass ratio q = 0.1889, a large over-contact degree of f=0.587, a very small difference between the component temperatures of △T = 53 K and an orbital inclination of i= 81°. It is known that deep (f > 50%), low-mass ratio (q < 0.25) overcontact binary stars are a very important resource for understanding the phenomena of Blue Straggler/FK Com-type stars. The formations of Blue Straggler stars and FK Com-type stars are unsolved problems in stellar astrophysics. One of the possible explanations for their formation is from the coalescence of W UMa-type overcontact binary systems. The absolute dimensions of ASAS 021209+2708.3 are estimated and its dynamical evolution is inferred.

  10. RACIONALIZACIJA ČASA MENJAVE ORODIJ ZA BRIZGANJE PLASTIČNIH MAS V PODJETJU ISKRA MEHANIZMI D.D. LIPNICA

    OpenAIRE

    Oblak, Tomaž

    2010-01-01

    Spremembe, ki so stalnica današnjega časa, nastajajo zelo hitro. S tem se tudi okolje, v katerem živimo, nenehno in zelo intenzivno spreminja. Takšemu okolju se morajo hitro in nenehno prilagajati tudi podjetja, če si želijo zagotoviti svoj dolgoročni obstoj. V diplomski nalogi je predstavljeno nekaj osnov o brizganju plastičnih mas in preoblikovanje sistema menjav orodij na strojih za brizganje plastičnih mas s pomočjo uporabe metode SMED. V nalogi so predstavljene prednosti, ki jih met...

  11. Estimation of the sensitivity and specificity of ASAS criteria for peripheral spondyloarthritis in patients with early psoriatic arthritis

    Directory of Open Access Journals (Sweden)

    E. Yu. Loginova

    2015-01-01

    Full Text Available Objective: to estimate the sensitivity and specificity of ASAS (Assessment of Spondyloarthritis International Society criteria for peripheral spondyloarthritis (SpA in patients with early psoriatic arthritis (ePsA.Subjects and methods. Examinations was made in 45 patients (17 men and 28 women with ePsA meeting the CASPAR (ClASsification criteria for Psoriatic ARthritis criteria (mean age, 37 years; disease duration, 1 year and in 20 patients (9 men and 11 women with signs of peripheral SpA meeting the ESSG (European Spondyloarthropathy Study Group criteria (mean age, 23 years; disease duration, 2.25 years; control group. The investigators estimated 78/76 tender/swollen joints and enthuses using MASES (Maastricht Ankylosing Spondylitis Enthesitis Score and assessed the presence of inflammatory spinal pain according to the ASAS criteria, psoriasis, uveitis, inflammatory bowel diseases, genitourinary and/or enteric infections, and a family history of SpA. They also performed X-ray studies of the hand and distal portions of the foot and pelvis and graded sacroilitis using the Kellgren scores. HLA-B27, C-reactive protein, and erythrocyte sedimentation rate were determined. The sensitivity/specificity, likelihood ratios, and clinical value of criteria were calculated.Results. 41/4 and 31/14 patents with ePsA met/unmet Criteria Sets I and II. The sensitivity/specificity of Sets I and II was 91.1/10% and 68.8/95%, respectively. One patient with ePsA and two patients in the control group did not meet one of the sing sets. The total sensitivity/specificity was 97.8/10%. In the control group, the sensitivity/specificity of Sets I and II was 91.1/100% and 68.8/100%, respectively. For ePsA, the positive likelihood ratio proved to be high for Set II (13.78% and low for Set I (1.01.Conclusion. ASAS Criteria Set I for peripheral SpA is of low value in identifying ePsA and Sign Set II shows a high value in diagnosing ePsA as it includes the major clinical

  12. Double-blind, placebo-controlled evaluation of 5-ASA suppositories in active distal proctitis and measurement of extent of spread using /sup 99m/Tc-labeled 5-ASA suppositories

    International Nuclear Information System (INIS)

    Patients with active distal proctitis received either 5-aminosalicylic (5-ASA) acid or identical placebo suppositories, 500 mg t.i.d. for 6 weeks. Activity at 3 and 6 wks was assessed using a Disease Activity Index (DAI), derived from four categories: number of daily evacuations more than usual, evacuations containing blood, sigmoidoscopy appearance, and physician's overall assessment. Each category was graded 0-3. There was thus 0-12 points scored ranging from complete remission to severe disease. A minimum score of 3 from two categories was necessary for study entry. Of 27 patients randomized, 14 received active medication and 13 placebo. Of the 14 patients, with initial mean DAI 7.1 +/- 1.8, 11 were in complete remission at 6 wks (78.6%). Whereas, there was no significant change in the placebo group, with initial mean DAI 7.1 +/- 1.8. An additional 6 patients with inflammatory bowel disease and 6 healthy volunteers were given /sup 99m/Tc-labelled 5-aminosalicylic acid suppositories. The extent of spread was limited to the rectum, and the suppositories were retained for 3 hours. There was no absorbed radioactivity. 5-ASA suppositories are safe, well-tolerated, and effective treatment for active distal proctitis

  13. Orbital and physical parameters of eclipsing binaries from the ASAS catalogue - IX. Spotted pairs with red giants

    Science.gov (United States)

    Ratajczak, M.; Hełminiak, K. G.; Konacki, M.; Smith, A. M. S.; Kozłowski, S. K.; Espinoza, N.; Jordán, A.; Brahm, R.; Hempel, M.; Anderson, D. R.; Hellier, C.

    2016-09-01

    We present spectroscopic and photometric solutions for three spotted systems with red giant components. Absolute physical and orbital parameters for these double-lined detached eclipsing binary stars are presented for the first time. These were derived from the V-, and I-band ASAS and WASP photometry, and new radial velocities calculated from high quality optical spectra we obtained with a wide range of spectrographs and using the two-dimensional cross-correlation technique (TODCOR). All of the investigated systems (ASAS J184949-1518.7, BQ Aqr, and V1207 Cen) show the differential evolutionary phase of their components consisting of a main-sequence star or a subgiant and a red giant, and thus constitute very informative objects in terms of testing stellar evolution models. Additionally, the systems show significant chromospheric activity of both components. They can be also classified as classical RS CVn-type stars. Besides the standard analysis of radial velocities and photometry, we applied spectral disentangling to obtain separate spectra for both components of each analysed system which allowed for a more detailed spectroscopic study. We also compared the properties of red giant stars in binaries that show spots, with those that do not, and found that the activity phenomenon is substantially suppressed for stars with Rossby number higher than ˜1 and radii larger than ˜20 R⊙.

  14. Advanced Steganography Algorithm Using Randomized Intermediate QR Host Embedded With Any Encrypted Secret Message: ASA_QR Algorithm

    Directory of Open Access Journals (Sweden)

    Somdip Dey

    2012-06-01

    Full Text Available Due to tremendous growth in communication technology, now it is a real problem / challenge to send some confidential data / information through communication network. For this reason, Nath et al. developed several information security systems, combining cryptography and steganography together, and the present method, ASA_QR, is also one of them. In the present paper, the authors present a new steganography algorithm to hide any small encrypted secret message inside QR CodeTM , which is then randomized and then, finally embed that randomized QR Code inside some common image. Quick Response Codes (or QR Codes are a type of two-dimensional matrix barcodes used for encoding information. It has become very popular recently for its high storage capacity. The present method is ASA_QR is a combination of strong encryption algorithm and data hiding in two stages to make the entire process extremely hard to break. Here, the secret message is encrypted first and hide it in a QR CodeTM and then again that QR CodeTM is embed in a cover file (picture file in random manner, using the standard method of steganography. In this way the data, which is secured, is almost impossible to be retrieved without knowing the cryptography key, steganography password and the exact unhide method. For encrypting data The authors used a method developed by Nath et al i.e. TTJSA, which is based on generalized modified Vernam Cipher, MSA and NJJSA method; and from the cryptanalysis it is seen that TTJSA is free from any standard cryptographic attacks, like differential attack, plain-text attack or any brute force attack. After encrypting the data using TTJSA,the authors have used standard steganographic method To hide data inside some host file. The present method may be used for sharing secret key, password, digital signature etc.

  15. Combining the ASA Physical Classification System and Continuous Intraoperative Surgical Apgar Score Measurement in Predicting Postoperative Risk.

    Science.gov (United States)

    Jering, Monika Zdenka; Marolen, Khensani N; Shotwell, Matthew S; Denton, Jason N; Sandberg, Warren S; Ehrenfeld, Jesse Menachem

    2015-11-01

    The surgical Apgar score predicts major 30-day postoperative complications using data assessed at the end of surgery. We hypothesized that evaluating the surgical Apgar score continuously during surgery may identify patients at high risk for postoperative complications. We retrospectively identified general, vascular, and general oncology patients at Vanderbilt University Medical Center. Logistic regression methods were used to construct a series of predictive models in order to continuously estimate the risk of major postoperative complications, and to alert care providers during surgery should the risk exceed a given threshold. Area under the receiver operating characteristic curve (AUROC) was used to evaluate the discriminative ability of a model utilizing a continuously measured surgical Apgar score relative to models that use only preoperative clinical factors or continuously monitored individual constituents of the surgical Apgar score (i.e. heart rate, blood pressure, and blood loss). AUROC estimates were validated internally using a bootstrap method. 4,728 patients were included. Combining the ASA PS classification with continuously measured surgical Apgar score demonstrated improved discriminative ability (AUROC 0.80) in the pooled cohort compared to ASA (0.73) and the surgical Apgar score alone (0.74). To optimize the tradeoff between inadequate and excessive alerting with future real-time notifications, we recommend a threshold probability of 0.24. Continuous assessment of the surgical Apgar score is predictive for major postoperative complications. In the future, real-time notifications might allow for detection and mitigation of changes in a patient's accumulating risk of complications during a surgical procedure.

  16. Innate and adaptive immune responses of Arctic charr (Salvelinus alpinus, L.) during infection with Aeromonas salmonicida subsp. achromogenes and the effect of the AsaP1 toxin.

    Science.gov (United States)

    Schwenteit, Johanna M; Breithaupt, Angele; Teifke, Jens P; Koppang, Erling O; Bornscheuer, Uwe T; Fischer, Uwe; Gudmundsdottir, Bjarnheidur K

    2013-09-01

    Aeromonas salmonicida subsp. achromogenes, the causative agent of atypical furunculosis in many fish species, secretes the toxic metalloendopeptidase AsaP1. This study aimed to analyze innate and adaptive immune parameters induced in Arctic charr (Salvelinus alpinus, L.) infected with wild type (wt) A. salmonicida subsp. achromogenes and its isogenic asaP1 deletion mutant (AsaP1-deficient). Head-kidney, liver and spleen were obtained from i.p. infected charr (wt, AsaP1-deficient), during a time schedule of 7 d post infection. Reverse transcription quantitative real-time PCR (RT-qPCR) was applied to study the expression of immune parameters: pro-inflammatory cytokines IL-1β and TNF-α; anti-inflammatory cytokine IL-10; chemokines CXCL-8 (IL-8) and CC-chemokine; the cytokines IFN-γ and IL-4/13A as tracers for Th1 and Th2 immune responses, respectively; and the cell markers CD8α and CD83. In addition, lymphoid organs were histopathologically examined at days 3 and 7 post infection, including B (IgM) and T (CD3ε) cell staining. The detected immune responses were initially driven by innate mechanisms represented by the up-regulation of pro-inflammatory cytokines and chemokines and later on by adaptive Th2 related responses cumulating in B-cell recruitment as shown by regulation of immune parameters in spleen and head-kidney, with significant differences between mutant and wt infected fish. Histological sections revealed IgM-positive cells around ellipsoid arterioles in spleen, while CD3ε positive cells were found in clusters scattered all over the section. However, histopathological differences were only detected between infected and non-infected fish, but not between AsaP1-deficient mutant and wt infected fish. This work represents the first study on innate and adaptive immune responses of Arctic charr induced by a bacterial infection. PMID:23811350

  17. Determination of pulsation periods and other parameters of 2875 stars classified as MIRA in the All Sky Automated Survey (ASAS)

    CERN Document Server

    Vogt, N; Fuentes-Morales, I; Vogt-Geisse, S; Arcos, C; Abarca, C; Agurto-Gangas, C; Caviedes, M; DaSilva, H; Flores, J; Gotta, V; Peñaloza, F; Rojas, K; Villaseñor, J I

    2016-01-01

    We have developed an interactive PYTHON code and derived crucial ephemeris data of 99.4% of all stars classified as 'Mira' in the ASAS data base, referring to pulsation periods, mean maximum magnitudes and, whenever possible, the amplitudes among others. We present a statistical comparison between our results and those given by the AAVSO International Variable Star Index (VSX), as well as those determined with the machine learning automatic procedure of Richards et al. 2012. Our periods are in good agreement with those of the VSX in more than 95% of the stars. However, when comparing our periods with those of Richards et al, the coincidence rate is only 76% and most of the remaining cases refer to aliases. We conclude that automatic codes require still more refinements in order to provide reliable period values. Period distributions of the target stars show three local maxima around 215, 275 and 330 d, apparently of universal validity, their relative strength seems to depend on galactic longitude. Our visual ...

  18. Arachidonic acid metabolism in TNS-induced chronic and immunologic enteritis in rats, and the effect of 5-ASA

    Directory of Open Access Journals (Sweden)

    F. J. Zijlstra

    1993-01-01

    Full Text Available Inflammation of the rat distal intestine was induced by intradermal sensitization and subsequent multiple intrajejunal challenge with the hapten 2,4,6-trinitrobenzenesulphonic acid (TNBS via an implanted catheter. The time course of the inflammatory reaction was followed by determination of the enteritis score and measurement of in vitro eicosanoid formation of homogenates of the gut after 0, 1, 2, 4, 7, 14 and 21 days of local daily challenge with 0.08% TNBS. There was a small initial increase of eicosanoid formation, reached at days 1 and 2, followed by a significant increase in metabolism of arachidonic acid on day 21. Although at day 1 a four-fold increase in inflammation score was reached, no further significant changes were observed during the following 3 weeks. The greatest increase in metabolite formation was observed in prostanoids TxB2, PGE2. and PGD2 and the 5-lipoxygenase product LTC4, whereas minor changes were found for LTB4 and other lipoxygenase products such as 12- and 15-HETE. The formation of these metabolites was already inhibited by low-dose 5-aminosalicylic acid (5-ASA, given orally twice daily during the 3 weeks challenge period, while the enteritis score was affected dosedependently.

  19. New Photometric Observations and the 2015 Eclipse of the Symbiotic Nova Candidate ASAS J174600-2321.3

    CERN Document Server

    Hambsch, Franz-Josef; Bernhard, Klaus; Otero, Sebastián

    2015-01-01

    The eclipsing binary system ASAS J174600-2321.3, which has shown a conspicuous brightening of ~4 magnitudes (V) in the past, was recently identified as a symbiotic nova candidate. A long-term photometric monitoring program was initiated in July 2014. In its present active stage, the system shows deep eclipses with an amplitude of ~3.5 magnitudes (V) that occur about every 33 months. In order to monitor the eclipse of 2015, AAVSO Alert Notice 510 was issued. During the ensuing campaign, AAVSO observers obtained 338 measurements in Johnson B, 393 measurements in Johnson V, and 369 measurements in Cousins I, as well as 27 visual observations. The present paper presents and analyzes these data from the AAVSO International Database, along with observations from the aforementioned photometric monitoring program. From these data, we were able to refine the orbital period to Porb = 1012.4 days. Furthermore, the data are suggestive of a slight decrease in mean brightness, which -if proven real- might indicate a declin...

  20. Search for evolutionary changes in Cepheid periods using the Harvard plate collection: ASAS 101538-5933.1

    Science.gov (United States)

    Berdnikov, L. N.

    2010-08-01

    In the plate collection of the Harvard College Observatory, we have obtained 528 photographic magnitude estimates for the recently discovered long-period classical Cepheid ASAS 101538-5933.1 ( P = 51.4 days). Together with the published photoelectric and CCD observations, our data have allowed us to construct an O-C diagram spanning a time interval of 120 years. The O-C diagram has the shape of a parabola, which has made it possible to determine for the first time the quadratic light elements and to calculate the rate of evolutionary increase in the period, dP/dt = 51.8 (±4.8) s yr-1 or dot P / P = 7.3 (±0.7) s, in agreement with the results of theoretical calculations for the third crossing of the instability strip. The available data reduced by the method of Eddington and Plakidis reveal small random period fluctuations that do not distort the evolutionary trend in the O-C residuals.

  1. Nitrate retention in riparian ground water at natural and elevated nitrate levels in North Central Minnesota

    Science.gov (United States)

    Duff, J.H.; Jackman, A.P.; Triska, F.J.; Sheibley, R.W.; Avanzino, R.J.

    2007-01-01

    The relationship between local ground water flows and NO3- transport to the channel was examined in three well transects from a natural, wooded riparian zone adjacent to the Shingobee River, MN. The hillslope ground water originated as recharge from intermittently grazed pasture up slope of the site. In the hillslope transect perpendicular to the stream, ground water NO3- concentrations decreased from ???3 mg N L-1 beneath the ridge (80 m from the channel) to 0.01 to 1.0 mg N L-1 at wells 1 to 3 m from the channel. The Cl- concentrations and NO3/Cl ratios decreased toward the channel indicating NO3- dilution and biotic retention. In the bankside well transect parallel to the stream, two distinct ground water environments were observed: an alluvial environment upstream of a relict beaver dam influenced by stream water and a hillslope environment downstream of the relict beaver dam. Nitrate was elevated to levels representative of agricultural runoff in a third well transect looted ???5 m from the stream to assess the effectiveness of the riparian zone as a NO3- sink. Subsurface NO3- injections revealed transport of up to 15 mg N L-1 was nearly conservative in the alluvial riparian environment. Addition of glucose stimulated dissolved oxygen uptake and promoted NO3- retention under both background and elevated NO 3- levels in summer and winter. Disappearance of added NO3- was followed by transient NO2- formation and, in the presence of C2H2, by N2O formation, demonstrating potential denitrification. Under current land use, most NO3- associated with local ground water is biotically retained or diluted before reaching the channel. However, elevating NO 3- levels through agricultural cultivation would likely result in increased NO3- transport to the channel. ?? ASA, CSSA, SSSA.

  2. Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group

    DEFF Research Database (Denmark)

    Rudwaleit, M; Jurik, A G; Hermann, K-G A;

    2009-01-01

    and to reach consensus on which MRI findings are essential for the definition of sacroiliitis. METHODS: Ten doctors (two radiologists and eight rheumatologists) from the ASAS/OMERACT MRI working group reviewed and discussed in three workshops MR images depicting sacroiliitis associated with SpA and other...... relevant for sacroiliitis have been defined by consensus by a group of rheumatologists and radiologists. These definitions should help in applying correctly the imaging feature "active sacroiliitis by MRI" in the new ASAS classification criteria for axial SpA.......BACKGROUND: Magnetic resonance imaging (MRI) of sacroiliac joints has evolved as the most relevant imaging modality for diagnosis and classification of early axial spondyloarthritis (SpA) including early ankylosing spondylitis. OBJECTIVES: To identify and describe MRI findings in sacroiliitis...

  3. Transactions of the Asae

    OpenAIRE

    Matak, K. E.; Wilson, J. H.; Duncan, S. E.; E. J. Wilson; Hackney, C. R.; Sumner, S S

    2003-01-01

    Lactose hydrolysis was investigated as a method of producing a more extrudable ice cream product. Ice cream mixes were treated with lactase from the microbial sources Kluyveromyces lactis and Aspergillus oryzae to produce 0% to 100% lactose hydrolysis. Compression measurements and yield stress tests of frozen ice cream were both affected by the temperature of the samples. As the temperature decreased, the work required to compress the ice cream 10 mm (firmness) and the torsional shear stress ...

  4. Study of ASA Algorithms

    OpenAIRE

    Ardam, Nagaraju

    2010-01-01

    Hearing aid devices are used to help people with hearing impairment. The number of people that requires hearingaid devices are possibly constant over the years, however the number of people that now have access to hearing aiddevices increasing rapidly. The hearing aid devices must be small, consume very little power, and be fairly accurate.Even though it is normally more important for the user that hearing impairment look good (are discrete). Once thehearing aid device prescribed to the user,...

  5. Verdsettelse av Ekornes ASA

    OpenAIRE

    Brakestad, Anniken Stokvik; Pedersen, Erika

    2011-01-01

    Denne oppgaven er en verdsettelse av Ekornes-konsernet. Verdsettelsen er i hovedsak basert på offentlig tilgjengelig informasjon, samt intervju med konsernsjefen i Ekornes Øyvind Tørlen og møbelhistoriker Eldar Høidal. Verdsettelsesmetoden vi har benyttet er kontantstrømsbasert modell. Verdien av konsernet er beregnet med utgangspunkt i en strategisk analyse, en regnskapsanalyse, beregnet avkastningskrav og estimerte fremtidige kontantoverskudd. Problemstillingen for oppgave...

  6. Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression.

    Directory of Open Access Journals (Sweden)

    Jie-Li Mao

    2016-01-01

    Full Text Available The gaseous phytohormone ethylene participates in the regulation of root growth and development in Arabidopsis. It is known that root growth inhibition by ethylene involves auxin, which is partially mediated by the action of the WEAK ETHYLENE INSENSITIVE2/ANTHRANILATE SYNTHASE α1 (WEI2/ASA1, encoding a rate-limiting enzyme in tryptophan (Trp biosynthesis, from which auxin is derived. However, the molecular mechanism by which ethylene decreases root growth via ASA1 is not understood. Here we report that the ethylene-responsive AP2 transcription factor, ETHYLENE RESPONSE FACTOR1 (ERF1, plays an important role in primary root elongation of Arabidopsis. Using loss- and gain-of-function transgenic lines as well as biochemical analysis, we demonstrate that ERF1 can directly up-regulate ASA1 by binding to its promoter, leading to auxin accumulation and ethylene-induced inhibition of root growth. This discloses one mechanism linking ethylene signaling and auxin biosynthesis in Arabidopsis roots.

  7. Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression

    Science.gov (United States)

    Wang, Zhen; Yu, Lin-Hui; Cai, Xiao-Teng; Xiang, Cheng-Bin

    2016-01-01

    The gaseous phytohormone ethylene participates in the regulation of root growth and development in Arabidopsis. It is known that root growth inhibition by ethylene involves auxin, which is partially mediated by the action of the WEAK ETHYLENE INSENSITIVE2/ANTHRANILATE SYNTHASE α1 (WEI2/ASA1), encoding a rate-limiting enzyme in tryptophan (Trp) biosynthesis, from which auxin is derived. However, the molecular mechanism by which ethylene decreases root growth via ASA1 is not understood. Here we report that the ethylene-responsive AP2 transcription factor, ETHYLENE RESPONSE FACTOR1 (ERF1), plays an important role in primary root elongation of Arabidopsis. Using loss- and gain-of-function transgenic lines as well as biochemical analysis, we demonstrate that ERF1 can directly up-regulate ASA1 by binding to its promoter, leading to auxin accumulation and ethylene-induced inhibition of root growth. This discloses one mechanism linking ethylene signaling and auxin biosynthesis in Arabidopsis roots. PMID:26745809

  8. The Araucaria Project. Accurate stellar parameters and distance to evolved eclipsing binary ASAS J180057-2333.8 in Sagittarius Arm

    CERN Document Server

    Suchomska, K; Smolec, R; Pietrzyński, G; Gieren, W; Stȩpień, K; Konorski, P; Pilecki, B; Villanova, S; Thompson, I B; Górski, M; Karczmarek, P; Wielgórski, P

    2015-01-01

    We have analyzed the double-lined eclipsing binary system ASAS J180057-2333.8 from the All Sky Automated Survey (ASAS) catalogue . We measure absolute physical and orbital parameters for this system based on archival $V$-band and $I$-band ASAS photometry, as well as on high-resolution spectroscopic data obtained with ESO 3.6m/HARPS and CORALIE spectrographs. The physical and orbital parameters of the system were derived with an accuracy of about 0.5 - 3%. The system is a very rare configuration of two bright well-detached giants of spectral types K1 and K4 and luminosity class II. The radii of the stars are $R_1$ = 52.12 $\\pm$ 1.38 and $R_2$ = 67.63 $\\pm$ 1.40 R$_\\odot$ and their masses are $M_1$ = 4.914 $\\pm$ 0.021 and $M_2$ = 4.875$\\pm$ 0.021 M$_\\odot$ . The exquisite accuracy of 0.5% obtained for the masses of the components is one of the best mass determinations for giants. We derived a precise distance to the system of 2.14 $\\pm$ 0.06 kpc (stat.) $\\pm$ 0.05 (syst.) which places the star in the Sagittariu...

  9. International 7{sup th} ASA waste days. Mechanical-biological waste treatment - performance of MBT. Proceedings; Internationale 7. ASA-Abfalltage. Mechanisch-Biologische Restabfallbehandlung - Leistungsfaehigkeit der MBA. Tagungsunterlagen

    Energy Technology Data Exchange (ETDEWEB)

    Barth, Josef; Rohring, Daniel (comps.)

    2008-07-01

    Within the International 7th ASA Waste Days at 13th to 15th February, 2008, at the Congress Center Hanover (Federal Republic of Germany), the following lectures were held: (1) Climate change and resource protection (M. Stock); (2) Legal requirements for immission protection of thermal and biological waste treatment (U. Lahl); (3) MBT and requirements in Europe incl. the Integrated Pollution prevention and Control IPPC Guideline (B. Zambrzycki); (4) MBT in Italy - A case study for a successful introduction (A. Confalonieri); (5) MBT with dry digestion - Example of Pohlsche Heide aus Bassum (B. Schulte); (6) MBT with dry digestion - Example of MBT Hanover (B. Vielhaber, C. Nuelle); (7) MBT with percolation - Example of Kahlenberg (G. Person, M. Schreiber, G. Gibis); (8) MBT with tunnel and table windrows decomposition process - Example Havelland; (9) MBT with tunnel and table windrows decomposition process - Example Linkenbach (S. Kraus, T. Sterk); (10) MBS Mechanical Biological Stabilisation Process - Example Osnabrueck (C. Niehaves); (11) Complete Eco-efficient Material and Energetic Recovery of Dried Municipal Solid Wastes (M. Monzel); (12) MPS Mechanical Physical Stabilisation Process - Example Berlin (D. Michalski, A. Wendt, U. Buell); (13) Secondary Fuels - Pretreatment, Specialities, Requirements, Current Sales and Markets (S. Flamme); (14) Corrosion in Biological Waste Treatment Plants (K. Fricke, T. Thiel, T. Bahr, R. Wallmann); (15) Problems at the Operation of Plants with the RTO Exhaust Gas Treatment in the Frame of MBT Processes (O. Carlowitz, O. Neese); (16) Problems and Solutions with the Analysis and Emission Measuring According to AbfABIV and 30. BImSchV (K. Ketelsen); (17) Securing of a High Plant Availability by Self-Supporting Cleansing, Maintenance and Care Programmes - Example of MBT Plant Croebern (J. Burchert); (18) Fire Control - Conceptions, Safety Measures, Cause of Fires - Example of MBT Ennigerloh and MBT Vorketzin (M. Pahlenkemper, B

  10. 810-nm InGaA1As/A1GaAs double quantum well semiconductor lasers with asymmetric waveguide structures

    Institute of Scientific and Technical Information of China (English)

    Lin Li; Guojun Liu; Zhanguo Li; Mei Li; Xiaohua Wang; Hui Li; Chunming Wan

    2008-01-01

    @@ The 810-nm InGaA1As/A1GaAs double quantum well (QW) semiconductor lasers with asymmetric waveguide structures, grown by molecular beam epitaxy, show high quantum efficiency and high-power conversion efficiency at continuous-wave (CW) power output. The threshold current density and slope efficiency of the device are 180 A/cm2 and 1.3 W/A, respectively. The internal loss and the internal quantum efficiency are 1.7 cm-1 and 93%, respectively. The 70% maximum power conversion efficiency is achieved with narrow far-field patterns.

  11. 耐候型ASA树脂的制备及其性能研究%Study on Preparation and Properties of Weather-resistant ASA Resin

    Institute of Scientific and Technical Information of China (English)

    马令庆; 林润雄

    2012-01-01

    A series of aciylate-styrene-acrylnnitrile (ASA) resin were synthesized by suspension polymerization with bulyl acrylate, styrene and acrylonitrile. The effect of rubber phase poly ( butyl acrylate) (PBA), ethyleneglycol dimethacrylate (EGDMA), allyl methacrylate (ALMA) and tertiary dodecyl mer-captan (TDDM) on the notched impact strength of the ASA resin were investigated. The effect of PBA content on the tensile strength and elongation at break was also investigated. It was found that the notched impact strength increases sharply when rubber phase content was beyond 20%. The notched impact strength of ASA resin reaches the maximum value when the amount of EGDMA, ALMA, TDDM were 0.43% , 0. 4%and 1% respectively. The tensile strength decreases slightly, and the elongation at break increases significantly with the amount of rubber phase increasing.%采用悬浮聚合法,以丙烯酸丁酯、苯乙烯和丙烯腈为原料,合成了一系列丙烯酸丁酯-苯乙烯-丙烯腈(ASA)树脂.考察了橡胶相聚丙烯酸丁酯(PBA)、交联剂二甲基丙烯酸乙二醇酯(EGDMA)、接枝剂甲基丙烯酸烯丙酯(ALMA)和摩尔质量调节剂十二烷基硫醇(TDDM)的用量对ASA树脂的冲击强度的影响;PBA质量分数对ASA树脂的拉伸强度和断裂伸长率的影响.结果表明:PBA质量分数达到20%后,ASA树脂的冲击强度大幅增加;EGDMA、ALMA和TDDM的质量分数分别为0.43%、0.4%和1%时,ASA树脂的冲击强度达到最大值;随PBA增加,ASA树脂的拉伸强度减小,断裂伸长率变大.

  12. Factores predictores de enfermedad residual en pacientes con lesión escamosa intraepitelial de alto grado tratadas mediante conización con asa de diatermia

    OpenAIRE

    Ramos Triviño, María Raquel

    2014-01-01

    Evaluar si las pacientes mayores de 35 años que presentan una pieza de conización con ?8 mm o ? 10mm de profundidad, márgenes positivos y VPH-AR positivo postconización presentan con mayor frecuencia enfermedad residual/recurrente. MATERIAL Y MÉTODOS: Se realizó un estudio observacional, descriptivo y retrospectivo de doscientas sesenta mujeres (edad media 35,2 ±13; rango 28-41) con CIN 2-3 tratadas mediante conización con asa de diatermia, incluyendo el seguimiento después de la cirugía, ent...

  13. Tidal Effects on Groundwater in a Very Small Tropical Island: A Study on the Groundwater Resources of Pag-asa Island, Kalayaan Island Group

    Directory of Open Access Journals (Sweden)

    John Ong

    2000-12-01

    Full Text Available The Pag-asa Island, with its very small land area and low relief, has a very limited fresh water supply occurring as a thin freshwater lens. Climate, topography, vegetation, lithology, human abstractions, and tides affect the volume of the freshwater lens. Topographic and hydrogeologic surveys, coupled with a 72-hour groundwater-monitoring program were done to assess the effects of tides on the freshwater lens.Groundwater parameters measured in wells during the monitoring program include variations in water table depths, specific electrical conductivity (SEC, and temperature. Changes in these parameters were then correlated with the observed variations of the tides.The groundwater levels oscillate with the tides at varying amplitudes. The hydraulic properties of the lithologies making up the island's aquifer influence the amplitude of the oscillations. Groundwater level oscillations are least in the reef materials and greatest in the sandy materials where it is nearly simultaneous with the tidal variations. High electrical conductivity values are marked in wells built near the coasts and in sandy materials.The average annual precipitation is approximately 2,020 mm. Based on empirical studies, the estimated sustainable yield for small tropical islands is 6% of the lowest annual rainfall or about 20,300 m3/yr for Pag-asa Island.

  14. Orbital and physical parameters of eclipsing binaries from the ASAS catalogue - VII. V1200 Centauri: a bright triple in the Hyades moving group

    Science.gov (United States)

    Coronado, J.; Hełminiak, K. G.; Vanzi, L.; Espinoza, N.; Brahm, R.; Jordán, A.; Catelan, M.; Ratajczak, M.; Konacki, M.

    2015-04-01

    We present the orbital and physical parameters of the detached eclipsing binary V1200 Centauri (ASAS J135218-3837.3) from the analysis of spectroscopic observations and light curves from the All-Sky Automated Survey (ASAS) and SuperWASP (Wide Angle Search for Planets) data base. The radial velocities were computed from the high-resolution spectra obtained with the OUC (Observatorio Universidad Católica) 50-cm telescope and PUCHEROS (Pontificia Universidad Católica High Echelle Resolution Optical Spectrograph) spectrograph and with 1.2-m Euler telescope and CORALIE spectrograph using the cross-correlation technique TODCOR. We found that the absolute parameters of the system are M1 = 1.394 ± 0.030 M⊙, M2 = 0.866 ± 0.015 M⊙, R1 = 1.39 ± 0.15 R⊙, R2 = 1.10 ± 0.25 R⊙. We investigated the evolutionary status and kinematics of the binary and our results indicate that V1200 Centauri is likely a member of the Hyades moving group, but the largely inflated secondary's radius may suggest that the system may be even younger, around 30 Myr. We also found that the eclipsing pair is orbited by another, stellar-mass object on a 351-d orbit, which is unusually short for hierarchical triples. This makes V1200 Cen a potentially interesting target for testing the formation models of multiple stars.

  15. Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study

    Directory of Open Access Journals (Sweden)

    Hedbäck Bo

    2009-06-01

    Full Text Available Abstract Background Despite the use of anti-platelet agents such as acetylsalicylic acid (ASA and clopidogrel in coronary heart disease, some patients continue to suffer from atherothrombosis. This has stimulated development of platelet function assays to monitor treatment effects. However, it is still not recommended to change treatment based on results from platelet function assays. This study aimed to evaluate the capacity of a static platelet adhesion assay to detect platelet inhibiting effects of ASA and clopidogrel. The adhesion assay measures several aspects of platelet adhesion simultaneously, which increases the probability of finding conditions sensitive for anti-platelet treatment. Methods With a randomised cross-over design we evaluated the anti-platelet effects of ASA combined with clopidogrel as well as monotherapy with either drug alone in 29 patients with a recent acute coronary syndrome. Also, 29 matched healthy controls were included to evaluate intra-individual variability over time. Platelet function was measured by flow cytometry, serum thromboxane B2 (TXB2-levels and by static platelet adhesion to different protein surfaces. The results were subjected to Principal Component Analysis followed by ANOVA, t-tests and linear regression analysis. Results The majority of platelet adhesion measures were reproducible in controls over time denoting that the assay can monitor platelet activity. Adenosine 5'-diphosphate (ADP-induced platelet adhesion decreased significantly upon treatment with clopidogrel compared to ASA. Flow cytometric measurements showed the same pattern (r2 = 0.49. In opposite, TXB2-levels decreased with ASA compared to clopidogrel. Serum TXB2 and ADP-induced platelet activation could both be regarded as direct measures of the pharmacodynamic effects of ASA and clopidogrel respectively. Indirect pharmacodynamic measures such as adhesion to albumin induced by various soluble activators as well as SFLLRN

  16. Measuring impairments of functioning and health in patients with axial spondyloarthritis by using the ASAS Health Index and the Environmental Item Set: translation and cross-cultural adaptation into 15 languages

    Science.gov (United States)

    Kiltz, U; van der Heijde, D; Boonen, A; Bautista-Molano, W; Burgos-Vargas, R; Chiowchanwisawakit, P; Duruoz, T; El-Zorkany, B; Essers, I; Gaydukova, I; Géher, P; Gossec, L; Grazio, S; Gu, J; Khan, M A; Kim, T J; Maksymowych, W P; Marzo-Ortega, H; Navarro-Compán, V; Olivieri, I; Patrikos, D; Pimentel-Santos, F M; Schirmer, M; van den Bosch, F; Weber, U; Zochling, J; Braun, J

    2016-01-01

    Introduction The Assessments of SpondyloArthritis international society Health Index (ASAS HI) measures functioning and health in patients with spondyloarthritis (SpA) across 17 aspects of health and 9 environmental factors (EF). The objective was to translate and adapt the original English version of the ASAS HI, including the EF Item Set, cross-culturally into 15 languages. Methods Translation and cross-cultural adaptation has been carried out following the forward–backward procedure. In the cognitive debriefing, 10 patients/country across a broad spectrum of sociodemographic background, were included. Results The ASAS HI and the EF Item Set were translated into Arabic, Chinese, Croatian, Dutch, French, German, Greek, Hungarian, Italian, Korean, Portuguese, Russian, Spanish, Thai and Turkish. Some difficulties were experienced with translation of the contextual factors indicating that these concepts may be more culturally-dependent. A total of 215 patients with axial SpA across 23 countries (62.3% men, mean (SD) age 42.4 (13.9) years) participated in the field test. Cognitive debriefing showed that items of the ASAS HI and EF Item Set are clear, relevant and comprehensive. All versions were accepted with minor modifications with respect to item wording and response option. The wording of three items had to be adapted to improve clarity. As a result of cognitive debriefing, a new response option ‘not applicable’ was added to two items of the ASAS HI to improve appropriateness. Discussion This study showed that the items of the ASAS HI including the EFs were readily adaptable throughout all countries, indicating that the concepts covered were comprehensive, clear and meaningful in different cultures. PMID:27752358

  17. Influence of demographic factors, basic blood test parameters and opioid type on propofol pharmacokinetics and pharmacodynamics in ASA I-III patients.

    Science.gov (United States)

    Bienert, Agnieszka; Wiczling, Paweł; Zaba, Czesław; Zaba, Zbigniew; Wolc, Anna; Marciniak, Ryszard; Grześkowiak, Edmund; Kusza, Krzysztof

    2011-01-01

    The aim of the study was to examine population pharmacokinetics (PK) and pharmacodynamics (PD) of propofol (CAS 2078-54-8) during total intravenous anesthesia monitored by spectral frequency index (SFx). Twenty-eight patients of ASA physical status I-III (ASA: American Society of Anesthesiologists) scheduled for laparoscopic cholecystectomy were included. In group I an anesthesia was induced with a bolus of propofol (2 mg/kg) and remifentanil (CAS 132875-61-7) (1.0 microg/kg), followed by a continuous infusion of remifentanil. In group II, an alfentanil (CAS 71195-58-9) (10 microg/kg) bolus dose was followed by a continuous infusion of alfentanil. The general anesthetic technique included propofol, opioid and muscle relaxant. During anesthesia, the propofol infusion rate (3-8 mg/kg/h) was adjusted to the SFx value. Venous blood samples were collected from the patients during 240 min after termination of the infusion. A two compartment model was used to describe propofol PK. A standard effect compartment model was used to describe the delay between the effect and the concentration of propofol. The SFx index was linked to the effect site concentrations through a sigmoidal Emax model. The influence of continuous (body weight, age, blood pressure, heart rate and blood oxygenation, serum protein, the erythrocyte count, hemoglobin and hematocrit, serum creatinine and creatinine clearance) and categorical (gender and the type of opioid) covariates on the pharmacokinetic and pharmacodynamic parameters was investigated. PK/PD analysis was performed using NONMEM. All the screened covariates did not influence propofol PK and PD, except of the opioid type. The central compartment volume of propofol was larger in the presence of remifentanil than in the presence of alfentanil.

  18. How well are the ASAS/OMERACT Core Outcome Sets for Ankylosing Spondylitis implemented in randomized clinical trials? A systematic literature review.

    Science.gov (United States)

    Bautista-Molano, Wilson; Navarro-Compán, Victoria; Landewé, Robert B M; Boers, Maarten; Kirkham, Jamie J; van der Heijde, Désirée

    2014-09-01

    This study aims to investigate how well the Assessment of SpondyloArthritis international Society (ASAS)/Outcome Measures in Rheumatology Clinical Trials (OMERACT) core set and response criteria for ankylosing spondylitis (AS) have been implemented in randomized controlled trials (RCTs) testing pharmacological and non-pharmacological interventions. A systematic literature search was performed up to June 2013 looking for RCTs in patients with axial spondyloarthritis (SpA) (AS and non-radiographic axial SpA). The assessed domains and instruments belonging to the core sets for disease-controlling anti-rheumatic therapy (DC-ART) and symptom-modifying anti-rheumatic drugs (SMARDs) were extracted. Results were reported separately for those trials published until 2 years after the publication of the core set (1 April 2001; 'control trials') and those trials published at least 2 years after the publication date ('implementation trials'). One hundred twenty-three articles from 99 RCTs were included in the analysis, comparing 48 'control trials' and 51 'implementation trials'. Regarding DC-ART core set, the following domains were significantly more frequently assessed in the 'implementation group' in comparison to the 'control group': 'physical function' (100 vs 41.7 %; p ≤ 0.001), 'peripheral joints/entheses' (100 vs 33.3 %; p ≤ 0.001) and 'fatigue' (100 vs 0 %; p ≤ 0.001). Three instruments were significantly more used in the 'implementation group': Bath Ankylosing Spondylitis Functional Index (BASFI) (100 vs 8.3 %; p = ≤ 0.001), CRP (92.3 vs 58.3 %; p = 0.01) and Bath Ankylosing Spondylitis Metrology Index (BASMI) (53.8 vs 0 %; p = 0.001). Regarding SMARD core set domains, physical function (92 vs 23 %; p ≤ 0.001) and fatigue (84 vs 17 %; p ≤ 0.001), as well as the instruments BASFI (88 vs 14 %; p ≤ 0.001) and BASMI (52 vs 0 %; p ≤ 0.001), increased significantly in the 'implementation group'. Twenty per cent of

  19. Six Months of Multi-Wavelength Follow-up of the Tidal Disruption Candidate ASASSN-14li and Implied TDE Rates from ASAS-SN

    CERN Document Server

    Holoien, T W -S; Prieto, J L; Stanek, K Z; Dong, Subo; Shappee, B J; Grupe, D; Brown, J S; Basu, U; Beacom, J F; Bersier, D; Brimacombe, J; Danilet, A B; Falco, E; Guo, Z; Jose, J; Herczeg, G J; Long, F; Pojmanski, G; Simonian, G V; Szczygiel, D M; Thompson, T A; Thorstensen, J R; Wozniak, P R

    2016-01-01

    We present ground-based and Swift photometric and spectroscopic observations of the candidate tidal disruption event (TDE) ASASSN-14li, found at the center of PGC 043234 ($d\\simeq90$~Mpc) by the All-Sky Automated Survey for SuperNovae (ASAS-SN). The source had a peak bolometric luminosity of $L\\simeq10^{44}$ ergs s$^{-1}$ and a total integrated energy of $E\\simeq7\\times10^{50}$ ergs radiated over the $\\sim6$ months of observations presented. The UV/optical emission of the source is well-fit by a blackbody with roughly constant temperature of $T\\sim35,000$ K, while the luminosity declines by roughly a factor of 16 over this time. The optical/UV luminosity decline is broadly consistent with an exponential decline, $L\\propto e^{-t/t_0}$, with $t_0\\simeq60$ days. ASASSN-14li also exhibits soft X-ray emission comparable in luminosity to the optical and UV emission but declining at a slower rate, and the X-ray emission now dominates. Spectra of the source show broad Balmer and helium lines in emission as well as st...

  20. Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study

    OpenAIRE

    Hedbäck Bo; Lindahl Tomas L; Jonasson Lena; Eriksson Andreas C; Whiss Per A

    2009-01-01

    Background: Despite the use of anti-platelet agents such as acetylsalicylic acid (ASA) and clopidogrel in coronary heart disease, some patients continue to suffer from atherothrombosis. This has stimulated development of platelet function assays to monitor treatment effects. However, it is still not recommended to change treatment based on results from platelet function assays. This study aimed to evaluate the capacity of a static platelet adhesion assay to detect platelet inhibiting effects ...

  1. Windows Messenger i Statoil ASA

    OpenAIRE

    Kollsgård, Mari

    2007-01-01

    Denne oppgaven er en kvalitativ undersøkelse av kommunikasjon i tverrfaglige prosjektarbeid med utgangspunkt i bruk av kommunikasjonskanalen Windows Messenger. De empiriske funnene i oppgaven er basert på en intervju- og observasjonsundersøkelse som ble gjort i Statoil ved årsskiftet 2006/2007.

  2. Soil development in the Nordic countries - Identification and quantification of factors and processes, and prerequisites for biological primary production. Extended abstracts from a Nordic Workshop 6-9 September 1994, Asa, Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Olsson, Mats [ed.

    1996-12-31

    This report is a compilation of abstracts from research presentations during a Nordic workshop at Asa in Sweden, September 6-9th 1994. The main goal with the workshop was to give insight in ongoing pedological research in Denmark, Finland, Norway and Sweden. Further aims were to form a basis for co-ordinated research that takes advantage of the amplitude in soils and climate, and scientific competence in the Nordic countries. The intention was also to initiate a Nordic soil data-bank to be used in research and teaching. Focus was placed on podzolised soils. Separate inputs have been made for all the 14 abstracts

  3. Genetic screening and analysis of suppressors of asa1-1 (soa) defective in jasmonate-mediated lateral root formation in Arabidopsis%茉莉酸诱导侧根形成缺陷突变体asa1-1抑制子(soa)的鉴定与遗传分析

    Institute of Scientific and Technical Information of China (English)

    李延安; 祁林林; 孙加强; 刘宏宇; 李传友

    2011-01-01

    外源茉莉酸处理野生型拟南芥能够促进侧根的形成,而在asa1-1突变体中茉莉酸抑制侧根的形成,这与在该突变体背景下茉莉酸显著降低PIN2蛋白水平密切相关.为了进一步研究茉莉酸诱导PIN2蛋白水平下调的分子机制,文章采用正向遗传学的方法筛选asa1-1抑制子soa,期望获得茉莉酸处理后侧根发育恢复的突变体.通过筛选鉴定获得2个突变体:soa563和soa856.这2个突变体在10 μmol/L茉莉酸甲酯处理条件下都能够恢复侧根发育,而且茉莉酸处理后PIN2蛋白水平降低的现象在soa563中被完全抑制,在soa856中被部分抑制.这些结果表明这两个突变基因可能影响了茉莉酸调控的PIN2蛋白水平下调途径,并且参于了茉莉酸对侧根发生的调控.对这两个基因的分离和功能研究将为阐明茉莉酸与生长素互作调控侧根发生的分子机制提供新的知识积累.%It has been shown that jasmonate modulates the lateral root development through crosstalk with auxin in Arabidopsis thaliana. Exogenous application of jasmonate stimulates lateral root formation in wild type but inhibits lateral root formation in asal-1. Our previous work has demonstrated that the lateral root formation defect of asal-1 is co-related with jasmonte effect on PIN2 protein levels. To further elucidate the molecular mechanisms underlying jasmonate-mediated reduction of plasma membrane (PM)-resident PIN2 abundance, we have conducted a genetic screen to identify suppressors of asal-1 (soa), which showed lateral root formation in the presence of jasmonate. Here, we described the basic characteri-zation of soa563 and soa856. We showed that both soa563 and soa856 displayed restored lateral root formation in response to exogenous jasmonate. In addition, jasmonate-induced PIN2:GFP reduction was blocked in these two mutants. Our on-going effort to identify genes defined by these mutants promise to shed new light on the understanding of

  4. Observation of a pressure-induced As-As hybridization associated with a change in the electronic state of Fe in the tetragonal phase of EuFe2As2.

    Science.gov (United States)

    Kobayashi, Hisao; Ikeda, Shugo; Sakaguchi, Yui; Yoda, Yoshitaka; Nakamura, Hiroki; Machida, Masahiko

    2013-01-16

    The electronic and vibrational properties of EuFe(2)As(2) in the tetragonal phase between 0 and 5 GPa have been investigated using (57)Fe Mössbauer spectroscopy and (57)Fe nuclear resonance inelastic scattering, respectively. We find a discontinuous increase of the center shift around 2.3 GPa, reflecting a change of the electronic state of Fe, and above 2.5 GPa a softening of the optical phonon modes associated with an increase of the relative volume of the FeAs(4) tetrahedron in the unit cell. Our findings reveal that an effective As-As hybridization along the c axis appears at approximately 2.3 GPa in the tetragonal phase of EuFe(2)As(2), along with a change in the electronic state of Fe, causing bulk superconductivity to appear at a low temperature. Consequently, the change in the electronic state of the Fe atom and the effective As-As hybridization play key roles in the pressure-induced superconductivity in the tetragonal phase of AFe(2)As(2).

  5. “旱立停”抗旱剂在冬播马铃薯上的应用效果%Effect of ASA on Potatoes Sowed in Winter

    Institute of Scientific and Technical Information of China (English)

    王朝友; 雷昌云; 张艳霞; 何文静; 李鹏飞; 袁志华; 王响军; 李成志; 邢丹英

    2013-01-01

    The effect of a drought-resistant agent,ASA,on Favorite,one cultivar of potatoes sowed in winter,was conducted in Lifu town,Jingzhou city,Hubei province.There were 5 ASA treatments:foliar spraying twice,seed dressing,foliar spraying once and seed dressing,foliar spraying twice and seed dressing,and foliar spraying water.The results showed that ASA could significantly shorten the emergence time,increase the plant height and the number of tubers per hole.And it was likely to promote tuber weight.Application of ASA could significantly increase the yield of Favorite.The yield of the treatment of foliar spraying twice and seed dressing was the highest,followed by that of foliar spraying twice,seed dressing and the yield of the control was the lowest.But the commercial potato rate decreased when treated with ASA.The yield of the treatment of foliar spraying twice and seed dressing and that of the treatment of foliar spraying twice were 25 546.0 kg/hm2 and 24 701.4 kg/hm2 respectively,significantly higher than that of other treatments.The yield of commercial potato of the treatment of foliar spraying once and seed dressing was 21 145.7 kg/hm2,which was significantly higher than that of other treatments.%在湖北荆州李埠镇对冬播马铃薯费乌瑞它用“旱立停”抗旱剂设置叶面喷施2次、拌种、叶面喷施1次+拌种、叶面喷施2次+拌种和叶面喷施清水(对照)5种处理,探讨其应用效果.结果表明,“旱立停”能显著缩短出苗时间,增加株高,增加单穴块茎数,并对块茎重有促进作用;施用抗旱剂能够显著提高产量,产量为喷施两次+拌种>喷施2次>叶面喷施1次+拌种>拌种>对照处理,但商品薯率低于对照;在试验中,喷施两次+拌种和喷施2次两处理的产量分别为25 546.0 kg/hm2、24 701.4 kg/hm2,显著高于其他处理,叶面喷施1次+拌种的商品薯产量为21 145.7 kg/hm2,极显著高于其他处理.

  6. Confiabilidad de la escala "Apreciación de la agencia de autocuidado" (ASA, segunda versión en español, adaptada para población colombiana Confiabilidade da escala "Apreciação da Agência de Autocuidado" (ASA, segunda versão em espanhol, adaptada ao povo colombiano Scale reliability "Self-care Agency Appreciation" (SAA, second version in Spanish, adapted for the Colombian population

    Directory of Open Access Journals (Sweden)

    ANITA VELANDIA ARIAS

    2009-07-01

    Full Text Available Objetivo: establecer la confiabilidad de la escala "Apreciación de la agencia de autocuidado" (ASA deEvers eIsenberg, segunda versión en español, y describir la capacidad de agencia de autocuidado en personas con factor de riesgo cardiovascular que asisten al programa de crónicos del servicio de consulta externa de un hospital de Bogotá, Colombia. Metodología: diseño descriptivo con abordaje cuantitativo que permitió evaluar la capacidad de agencia de autocuidado en una muestra de 201 personas con factores de riesgo cardiovascular que asistieron al programa de crónicos en un hospital de Bogotá, mediante el empleo de la escala ASA, segunda versión en español. A esta escala se le realizó la medición de la confiabilidad a través del cálculo del valor del coeficiente de alfa-Cronbach. Resultados: se encontró que el 35,8% de los participantes tuvo buena capacidad de agencia de autocuidado y el 62,6%, regular. Se aplicó el coeficiente de confiabilidad alfa-Cronbach a la escala ASA y se obtuvo un valor de 0,744. Conclusiones: se observa una diferencia de 0,026 por debajo del valor reportado en la medición de confiabilidad de la escala ASA, realizada por la doctora Gallegos, primera versión en español, para un contexto mexicano; estos resultados significan que los 24 ítems analizados de la escala miden un mismo concepto y por lo tanto se concluye que el instrumento posee consistencia interna.Objectivo: estabelecer a confiabilidade da escala "Apreciação da agência de autocuidado" (ASA de Evers e Isenberg, segunda versão em espanhol, e descreve a capacidade de agência de autocuidado em pessoas com fatores de risco cardiovascular que utilizam o programa de crônicos do serviço de consulta externa de um hospital de Bogotá, Colômbia. Metodologia: delineamento descritivo com abordagem quantitativa que permitiu avaliar a capacidade de agência de autocuidado dentro de uma amostra de 201 pessoas com fatores de risco cardiovascular

  7. “Conviver com a seca”: contribuição da Articulação do Semi-Árido/ASA para o desenvolvimento sustentável

    Directory of Open Access Journals (Sweden)

    Ghislaine Duque

    2008-01-01

    Full Text Available The Brazilian semi-arid region poses huge challenges to sustainable development: the edapho-climatic characteristics, undoubtedly, but also, and much more so, the prevalence of a policy based on greenrevolution principles and incentives to agribusiness, on one hand, and on assistentialism for the poor in the countryside, on the other. Against the “fighting draught” paradigm – carried on by the construction of large water reservoirs and water distribution through tank trucks, leading to dependence, and its use for irrigation, harming the environment – family farmers and their institutions, organized by the Semi-Arid Articulation/ASA, complain about the “living with draught” principle. They restore and promote experiences born from popular knowledge and improved through contact with scientific knowledge, and change them into references to propose a different public policy model to the public authorities. This is how the P1MC – Programa de Formação e Mobilização para Convivência no Semi-Árido: um Milhão de Cisternas Rurais (Education and Mobilization Program for Semi-Arid Living: One Million Rural Cisterns was born, followed by P1+2 – Programa Uma Terra e Duas Águas (One Earth/Land and Two Waters Program. The strategy used by the farmers to diversify activities and create water reserves, forage, and seeds, and agro-ecological principles, are at the basis of the development model proposed by ASA. The methodology developed fosters farmer protagonism and its organization, safeguarding the sustainability of the process.

  8. Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity

    Science.gov (United States)

    Correa-Basurto, José; Rosales Hernández, Martha Cecilia; Padilla Martínez, Itzia Irene; Mendieta-Wejebe, Jessica Elena

    2016-01-01

    5-[(4-carboxybutanoyl)amino]-2-hydroxybenzoic acid (C2) is a novel synthetic derivative of 5-aminosalicylic acid (5-ASA), which is currently being evaluated ex vivo as an anti-inflammatory agent and has shown satisfactory results. This study aimed to obtain the pharmacokinetic profiles, tissue distribution and plasma protein binding of C2 in Wistar Rats. Additionally, an HPLC method was developed and validated to quantify C2 in rat plasma. The pharmacokinetic profiles of intragastric, intravenous and intraperitoneal administration routes at singles doses of 100, 50, and 100 mg/kg, respectively, were studied in Wistar rats. The elimination half-life of intravenously administered C2 was approximately 33 min. The maximum plasma level of C2 was reached approximately 24 min after intragastric administration, with a Cmax value of 2.5 g/mL and an AUCtot value of 157 μg min-1/mL; the oral bioavailability was approximately 13%. Following a single intragastric or oral dose (100 mg/kg), C2 was distributed and detected in all examined tissues (including the brain and colon). The results showed that C2 accumulates over time. The plasma protein binding results indicated that the unbound fraction of C2 at concentrations of 1 to 20 μg/mL ranged from 89.8% to 92.5%, meaning that this fraction of C2 is available to cross tissues. Finally, the blood-plasma partitioning (BP ratio) of C2 in rat plasma was 0.71 and 0.6 at concentrations of 5 and 10 μg/mL, respectively, which indicates that C2 is free in the plasmatic phase and not inside blood cells. The results of this study suggest that a fraction of the administered C2 dose is absorbed in the stomach, and the fraction that is not absorbed reaches the small intestine and colon. This distribution constitutes the main advantage of C2 compared with 5-ASA for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). PMID:27454774

  9. Bioaccumulation and associated dietary risks of Pb, Cd, and Zn in amaranth (Amaranthus cruentus) and jute mallow (Corchorus olitorius) grown on soil irrigated using polluted water from Asa River, Nigeria.

    Science.gov (United States)

    Ogunkunle, Clement Oluseye; Ziyath, Abdul M; Adewumi, Faderera Esther; Fatoba, Paul Ojo

    2015-05-01

    Dietary uptake of heavy metals through the consumption of vegetables grown on polluted soil can have serious human health implications. Thus, the study presented in this paper investigated the bioaccumulation and associated dietary risks of Pb, Zn, and Cd present in vegetables widely consumed in Nigeria, namely amaranth and jute mallow, grown on soil irrigated with polluted water from Asa River. The study found that the soil was polluted with Zn, Pb, and Cd with Pb and Cd being contributed by polluted river, while Zn was from geogenic sources. The metal concentration in amaranth and jute mallow varied in the order of Zn > Pb > Cd and Zn > Pb ≈ Cd, respectively. Jute mallow acts as an excluder plant for Pb, Cd, and Zn. Consequently, the metal concentrations in jute mallow were below the toxic threshold levels. Furthermore, non-cancer human health risk of consuming jute mallow from the study site was not significant. In contrast, the concentrations of Pb and Cd in amaranth were found to be above the recommended safe levels and to be posing human health risks. Therefore, further investigation was undertaken to identify the pathways of heavy metals to amaranth. The study found that the primary uptake pathway of Pb and Cd by amaranth is foliar route, while root uptake is the predominant pathway of Zn in amaranth. PMID:25899541

  10. Vertical Electrical Sounding Investigation for Delineation of Geoelectric Layers and Evaluation of Groundwater Potential in Ajagba, Asa and Ikonifin Localities of Ola Oluwa Local Government Area of Osun State, South Western Nigeria

    Directory of Open Access Journals (Sweden)

    M. Onimisi

    2013-10-01

    Full Text Available Vertical Electrical Sounding (VES surveys were carried out at Ajagba, Asa and Ikonifin communities in the north of Ola Oluwa local government area of Osun state, Nigeria in order to delineate the geoelectric layers in the area as well as evaluate the groundwater potential. The area is in the basement complex terrain of Nigeria where the occurrence of groundwater is highly unpredictable and hence requires the use of hydrologic, geophysical and geologic surveys to achieve success in groundwater development programs. The survey delineated a maximum of four geoelectric layers which may be interpreted to correspond to four geologic layers viz the topsoil, weathered basement, partly weathered/fractured basement and the fresh basement. The weathered basement and the partly weathered/fractured basement layers constitute the aquifer units. The partly weathered/fractured layer is significant in enhancing the ground water potential in this area because of its relatively low resistivity resulting from its high fracture frequency. The ground water potential in the area varies from medium to high. Groundwater development is therefore feasible in these communities.

  11. Validación de apariencia, contenido y consistencia interna de la Escala de Apreciación de Agencia de Autocuidado (ASA para Costa Rica, segunda versión en español

    Directory of Open Access Journals (Sweden)

    Viriam Leiva Díaz

    2015-07-01

    Full Text Available Introducción: Este artículo presenta los resultados obtenidos del proceso de validación de apariencia, contenido y consistencia interna al que fue sometida la segunda versión en español de la escala ASA aplicada a población  costarricense.Método: Este estudio es descriptivo, transversal, con un enfoque cuantitativo, con un diseño no experimental y psicométrico, realizado con una muestra de 211 personas en la etapa de la adultez temprana, intermedia y tardía, según su condición de salud conocidas como sanas o con diagnóstico de enfermedad crónica.Resultados: La investigación determinó que el análisis factorial con la aplicación de métodos estadísticos, la prueba de Kaiser-Meyer-Olkin (KMO con resultado de 0,79, evidenció la viabilidad de la escala, en la que las variables miden factores comunes con una varianza total del 64,14%.Conclusión: El análisis factorial arrojó siete ejes factoriales y obtuvo valores adecuados que demuestran su validez.

  12. Effects of Exogenous AsA on the Growth of Dianthus chinensis Seedlings Under Soil Cd Stress%外源AsA对土壤重金属镉胁迫下石竹(Dianthus chinensis)幼苗生长的影响

    Institute of Scientific and Technical Information of China (English)

    丁继军; 潘远智; 刘柿良; 何杨; 王力; 李丽

    2013-01-01

    In order to investigate alleviating effects of exogenous ascorbic acid(AsA) for Dianthus c hinensis seedlings suffering cadmium stress,a greenhouse pot experiment was conducted to explore the effects of different concentrations(0,20,40,60,80 mg· L-1 and 100 mg· L-1)of exogenous AsA on the growth of Dianthus chinensis seedlings.Cd (50 mg· kg-1) significantly inhibited the growth of Dianthus chinensis seedlings.Spraying exogenous AsA(≤40 mg· L-1) markedly alleviated the stress effect of Cd.Exogenous AsA significantly increased the activities of the catalase (CAT),peroxidase (POD),ascorbate peroxidase (APX),monodehydroascorbate reductase (MDAR),dehydroascorbate reductase(DHAR) and glutathione reductase(GR).Compared with Dianthus chinensis seedlings under Cd stress,exogenous AsA also significantly increased the biomass,plant height,number of tillers,and the contents of AsA and GSH.Exogenous AsA markedly reduced the cell membrane permeability,the shoots Cd content,production rates and accumulative amount of H2O2.However,the alleviating effect of exogenous AsA was showed as quadratic curve.With higher concentration,the exogenous AsA showed pro-oxidant effects.The present study indicated that the optimal concentration of exogenous AsA was 35~45 mg· L-1 to alleviate the Cd stress.%为探讨外源抗坏血酸(AsA)对土壤重金属镉(Cd)胁迫下石竹(Dianthus chinensis)幼苗生长的影响,采用温室盆栽试验,研究了不同浓度(0、20、40、60、80、100 mg·L-1)的外源AsA处理对50 mg·kg-1 Cd胁迫下石竹幼苗生长的影响.结果表明:50 mg·kg-1Cd显著抑制了石竹幼苗的生长,≤40 mg·L-1的外源AsA可显著缓解Cd胁迫,石竹幼苗的生物量、株高、分蘖数、过氧化氢酶(CAT)、过氧化物酶(POD)、抗坏血酸过氧化物酶(APX)、单脱氢抗坏血酸还原酶(MDAR)、脱氢抗坏血酸还原酶(DHAR)、谷胱甘肽还原酶(GR)的活性,AsA和谷胱甘肽(GSH)的含量都显著高于Cd胁迫下石竹幼苗,而

  13. Verdsettelse av Norwegian Air Shuttle ASA

    OpenAIRE

    Gangsø, Dan-Henning M.

    2012-01-01

    Problemstillingen for denne oppgaven er å finne frem til verdien av aksjene til Norwegian Air Shuttle. Det er blitt brukt et beskrivende design, basert på kvalitative og kvantitative sekundærdata, for å komme frem til konklusjonene. Første del av oppgaven består av en historisk presentasjon av Norwegian med fokus på store vendepunkter. Deretter gjennomgås tre grundige analyser av forhold som er relevante for verdsettelsen. Det første kapittelet handler om ytre makroforhold som har betyd...

  14. Pemahaman Konsep Tauhid Asas Keharmonian Kepelbagaian Agama

    Directory of Open Access Journals (Sweden)

    Nur Farhana Abdul Rahman

    2012-06-01

    Full Text Available Efforts in forming harmonious existence among religious believers have produced two important responses and approaches as reaction to religious diversity. The first type views religious diversity as a need for implementing active tolerance attitude among religious believers although this does not proceed to relativism and the second type of view acknowledges the unity of religious truths. Essentially, Islam has many models and systems in dealing with religious diversity. In evidence, the essence of Islamic teachings is the obligation of Muslims to act in justice and peaceful to all human beings regardless of their religious beliefs. This has also been described in Al-Faruqi’s discourse on meta-religion. However, the Islamic teachings that emphasize on respect to other religious believers should not exceed the basic tenets of Islamic creed and faith. This study found that the concept of tawhid in Islam can be a strong argument in cultivating tolerance and harmony among people of different religions.

  15. ASA's Chandra Neon Discovery Solves Solar Paradox

    Science.gov (United States)

    2005-07-01

    NASA's Chandra X-ray Observatory survey of nearby sun-like stars suggests there is nearly three times more neon in the sun and local universe than previously believed. If true, this would solve a critical problem with understanding how the sun works. "We use the sun to test how well we understand stars and, to some extent, the rest of the universe," said Jeremy Drake of the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass. "But in order to understand the sun, we need to know exactly what it is made of," he added. It is not well known how much neon the sun contains. This is critical information for creating theoretical models of the sun. Neon atoms, along with carbon, oxygen and nitrogen, play an important role in how quickly energy flows from nuclear reactions in the sun's core to its edge, where it then radiates into space. Chandra X-ray Spectrum of II Pegasi Chandra X-ray Spectrum of II Pegasi The rate of this energy flow determines the location and size of a crucial stellar region called the convection zone. The zone extends from near the sun's surface inward approximately 125,000 miles. The zone is where the gas undergoes a rolling, convective motion much like the unstable air in a thunderstorm. "This turbulent gas has an extremely important job, because nearly all of the energy emitted at the surface of the sun is transported there by convection," Drake said. The accepted amount of neon in the sun has led to a paradox. The predicted location and size of the solar convection zone disagree with those deduced from solar oscillations. Solar oscillations is a technique astronomers previously relied on to probe the sun's interior. Several scientists have noted the problem could be fixed if the abundance of neon is in fact about three times larger than currently accepted. Attempts to measure the precise amount of neon in the Sun have been frustrated by a quirk of nature; neon atoms in the Sun give off no signatures in visible light. However, in a gas heated to millions of degrees, neon shines brightly in X-rays. Stars like the sun are covered in this super-heated gas that is betrayed by the white corona around them during solar eclipses. However, observations of the sun's corona are very difficult to analyze. Labeled Illustration of Convection in Sun-like Star Labeled Illustration of Convection in Sun-like Star To probe the neon content, Drake and his colleague Paola Testa of the Massachusetts Institute of Technology in Cambridge, Mass., observed 21 sun-like stars within a distance of 400 light years from Earth. These local stars and the sun should contain about the same amount of neon when compared to oxygen. However, these close stellar kin were found to contain on average almost three times more neon than is believed for the sun. "Either the sun is a freak in its stellar neighborhood, or it contains a lot more neon than we think," Testa said. These Chandra results reassured astronomers the detailed physical theory behind the solar model is secure. Scientists use the model of the sun as a basis for understanding the structure and evolution of other stars, as well as many other areas of astrophysics. "If the higher neon abundance measured by Drake and Testa is right, then it is a simultaneous triumph for Chandra and for the theory of how stars shine," said John Bahcall of the Institute for Advanced Study, Princeton, N.J. Bahcall is an expert in the field who was not involved in the Chandra study. Drake is lead author of the study published in this week's issue of the journal Nature. NASA's Marshall Space Flight Center, Huntsville, Ala., manages the Chandra program for the agency's Science Mission Directorate. The Smithsonian Astrophysical Observatory controls science and flight operations from the Chandra X-ray Center in Cambridge, Mass. Additional information and images are available at: http://chandra.harvard.edu and http://chandra.nasa.gov

  16. Edexcel Physics ASA2 student unit guide

    CERN Document Server

    Bridgeman, Keith

    2013-01-01

    Perfect for revision, these guides explain the unit requirements, summarise the content and include specimen questions with graded answers. Each full-colour New Edition Student Unit Guide provides ideal preparation for your unit exam:.; Feel confident you understand the unit: each guide comprehensively covers the unit content and includes topic summaries, knowledge check questions and a reference index.; Get to grips with the exam requirements: the specific skills on which you will be tested are explored and explained.; Analyse exam-style questions: graded student responses will help you focus

  17. Advanced Sensors and Applications Study (ASAS)

    Science.gov (United States)

    Chism, S. B.; Hughes, C. L.

    1976-01-01

    The present EOD requirements for sensors in the space shuttle era are reported with emphasis on those applications which were deemed important enough to warrant separate sections. The application areas developed are: (1) agriculture; (2) atmospheric corrections; (3) cartography; (4) coastal studies; (5) forestry; (6) geology; (7) hydrology; (8) land use; (9) oceanography; and (10) soil moisture. For each application area. The following aspects were covered: (1) specific goals and techniques, (2) individual sensor requirements including types, bands, resolution, etc.; (3) definition of mission requirements, type orbits, coverages, etc.; and (4) discussion of anticipated problem areas and solutions. The remote sensors required for these application areas include; (1) camera systems; (2) multispectral scanners; (3) microwave scatterometers; (4) synthetic aperture radars; (5) microwave radiometers; and (6) vidicons. The emphasis in the remote sensor area was on the evaluation of present technology implications about future systems.

  18. 烯基琥珀酸酐疏水化淀粉的性能及其表面施胶应用研究%Study on the performance and of hydrophobic starch modified by ASA and its application as surface sizing agent

    Institute of Scientific and Technical Information of China (English)

    杨晓武; 沈一丁; 李培枝; 黄芳

    2013-01-01

    为制备一种环境友好型表面施胶剂,采用烯基琥珀酸酐(ASA)对淀粉进行疏水改性,使用红外光谱(FT-IR)、X射线衍射(XRD)、扫描电镜(SEM)和表面张力仪等测试手段对其性能进行了表征,并将烯基琥珀酸酐疏水化改性淀粉作为纸张表面施胶剂进行应用研究.结果表明,在淀粉分子上成功引入疏水性长链,淀粉颗粒形貌发生了变化,烯基琥珀酸酐疏水化淀粉施胶浓度为5%时,其施胶度可达206s,动态接触角达120°以上.%In order to prepare a kind of environment-friendly surface sizing agent, the starch was modified by alkenyl succinic anhydride (ASA) , and the performances were characterized by the infrared spectrum (FT-IR) , X-ray diffraction (XRD) , scanning electron microscopy (SEM), surface tension meter and so on, and the sur-face sizing effect of hydrophobic starch modified by ASA was studied. The results showed that, the hydropho-bic long chain was introduced onto the guar gum successfully, the morphology of starch granules changed. As the dosage of modified guar gum was 5%, the sizing degree was up to 206s, and the dynamic contact angle (DCA) was more than 120°.

  19. Variations of Three Antioxidant Enzymes Activities and AsA Content in Leaves of Solanum nigrum L. under Cadmium Stress%镉胁迫下龙葵叶中三种抗氧化酶的活性和抗坏血酸含量的变化

    Institute of Scientific and Technical Information of China (English)

    唐秀梅; 龚春风; 刘鹏; 徐根娣; 蔡妙珍; 吴琼鸯

    2008-01-01

    水培龙葵,设置0、10、25、50、100 mg·L-15个镉浓度,处理17和34 d后测定叶片中3个保护酶活性和抗坏血酸含量.结果表明,经镉处理后的过氧化物酶(POD)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和抗坏血酸(ASA)含量都增加,25、100mg·L-1镉处理的差异显著;处理34d后,3个酶的活性呈现随着镉浓度升高而变化的规律,三者都表现出先升高后降低再升高的趋势.

  20. Preliminary study of synthesis, characterization and application of core-shell nanofibers containing 5-ASA%载5-氨基水杨酸的核壳纳米纤维制备、表征及应用的初步研究

    Institute of Scientific and Technical Information of China (English)

    张妮萍; 贾张军; 刘宏翔; 许茜

    2011-01-01

    目的:构建基于载5-氨基水杨酸(5-ASA)核壳纳米纤维的递药系统,以期达到药物在结肠定位释放的目的.方法:以丙烯酸树脂Eudragit S100为壳层材料、乙基纤维素为核层材料,采用同轴电纺技术制备载5-ASA的核壳纳米纤维,考察制备核壳纳米纤维的主要影响因素;以包封率表征药物的包载情况;扫描电子显微镜(SEM)和透射电子显微镜(TEM)表征纤维的表面形态、直径、核壳结构的形成;以惠迪为参比制剂,在模拟体内胃、小肠、结肠pH环境的释放介质中,评价其释药行为的结肠定位特征.结果:成功制备了载5-ASA核壳纳米纤维,实验条件下初步获得了可用于载药的核壳纳米纤维;纤维呈表面光滑的圆柱形,形成较完全的核壳结构,平均直径为360 nm;5-ASA包载于纤维的核内,包封率为21-0%(n=6);5-ASA在模拟胃液pH环境中2 h几乎不释放,模拟小肠液pH环境中4 h的累积释放小于20%,而在模拟结肠液pH环境中4 h内可达到100%完全释放,体外结肠定位释药行为优于惠迪.结论:载5-ASA的核壳纳米纤维作为5-ASA的口服结肠定位给药系统(OCDDS)具有可行性.%Objective: To build oral colon-specific drug delivery system based on core-shell nanofibers for the purpose of the controlled release of a drug in the colon parts. Methods: Coaxial electrospinning technology was used to prepare core-shell nanofibers and drug was added into the core, selecting acrylic resin Eudragit S100 as the shell layer material and choosing ethylcellulose as the core layer material. Investigate the main effect factors during the process of preparing of core-shell nanofibers. Characterize the condition of drug package containing based on encapsulation efficiency. The shape, diameter, and core-shell structure of nanofibers were characterized by TEM and SEM. Making HuiDi as the reference preparation, in a simulated body's stomach, small intestine, colon Ph environment of release media

  1. Validación de apariencia, contenido y consistencia interna de la Escala de Apreciación de Agencia de Autocuidado (ASA para Costa Rica, segunda versión en español para población conocida sana

    Directory of Open Access Journals (Sweden)

    Viriam Leiva Díaz

    2015-12-01

    Full Text Available Introducción. Este artículo presenta los resultados obtenidos del proceso de validación de apariencia, contenido y consistencia interna al que fue sometida la segunda versión en español de la escala ASA con población costarricense conocida sana. Metodología. Se trata de un estudio descriptivo, transversal, de enfoque cuantitativo, diseño no experimental y psicométrico, realizado con una muestra de 105 personas en etapa de adultez temprana, intermedia y tardía. Resultado. La investigación determinó que el estudio factorial (método ACP con rotación Varimax sugirió el análisis con cinco ejes factoriales que explican el 60,03% de la varianza total en Costa Rica. Del resultado de los dominios anteriores, se destaca que en la mayoría de ellos predomina la categoría relacionada al requisito universal de prevención de peligros contra la vida, el funcionamiento y bienestar humano. Conclusión. En Costa Rica, la enfermería puede contar con un instrumento válido y confiable para medir la capacidad de agencia de autocuidado en las personas conocidas sanas que se encuentran en la etapa de la adultez.

  2. AHA/ASA关于卒中和短暂性脑缺血发作患者卒中预防推荐的更新%Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

    Institute of Scientific and Technical Information of China (English)

    Robert J. Adams; S. Claibome Johnston; Irene Katzan; Margaret Kelly-Hayes; Edgar J. Kenton; Michael Marks; Ralph L. Sacco; Lee H. Schwamm; 赵洪芹; 李海峰; Greg Albers; Mark J. Alberts; Oscar Benavente; Karen Furie; Larry B. Goldstein; Philip Gorelick; Jonathan Halperin; Robert Harbaugh

    2008-01-01

    @@ 在卒中和短暂性脑缺血发作(transient ischemicattack,TIA)患者卒中预防推荐[1]发表以后,美国心脏协会和美国卒中协会(American Heart Association/American Stroke Association,AHA/ASA)著述委员会对最近的一些试验结果进行了回顾.本文的目的是对这些新资料做简要回顾、更新某些推荐意见并说明进行这些修改的理由.在2个领域已发表了一些新的重要临床试验结果:(1)在非心源性栓塞所致缺血性卒中或TIA患者卒中二级预防中具体抗血小板药的应用;(2)他汀类药物在预防卒中复发中的应用.

  3. Strategic analysis & fundamental valuation of Solstad Offshore ASA

    OpenAIRE

    Døsen, Liv Karina; Hovden, Anders Hodder

    2014-01-01

    This master thesis, in the field of financial economics, is written with the purpose of valuing Solstad Offshore ASA’s equity at 31.12.2012. Solstad’s price per share at 31.12.2012 was NOK 100. The reason why we estimate from this date is due to the late annual report for 2013. Two valuing methods are applied – fundamental valuation and comparable valuation. The comprehensive thesis can be divided into five sections: - Strategic Analysis - Financial Statements Analysis - Future E...

  4. ASA24® Instructions for Study Staff & Respondents

    Science.gov (United States)

    The following documents have been created by the National Cancer Institute (NCI) as resources for study staff and Respondents. Each resource is available as a ready-to-use PDF as well as in Word format to allow users to adapt the content as desired.

  5. ASA conference on radiation and health: Coolfont IV. Final report

    International Nuclear Information System (INIS)

    The conference included presentations on (1) DOE follow-up studies of exposed workers; (2) probability of causation; (3) radon; (4) occupational mortality studies; (5) life-table construction; (6) morbidity versus mortality studies; (7) old and new risks in radium dial painters; and (8) mental retardation in A-bomb survivors

  6. Strategisk regnskapsanalyse og verdsettelse av Renewable Energy Corporation ASA

    OpenAIRE

    Søvik, Lene; Sømme, Tore

    2011-01-01

    Hva er vi villige til å betale for en aksje? ”Price is what you pay, but value is what you get” av Professor Stephen H. Penman i boken ”Financial Statement Analysis and Security Valuation” 2010, poengterer at en aktiv investor ser på prisen for en aksje som kostnaden ved en investering, og ikke verdien av en aksje. I denne utredningen ønsker vi å utfordre markedsverdien til REC, og undersøke om aksjen er over eller underpriset i forhold til børsverdi. Dette har vi gjort ved å foreta en f...

  7. Individual dosing of ASA prophylaxis by controlling platelet aggregation.

    Science.gov (United States)

    Syrbe, G; Redlich, H; Weidlich, B; Ludwig, J; Kopitzsch, S; Göckefitz, A; Herzog, T

    2001-07-01

    Acetylsalicylic acid is widely used in the primary and secondary prevention of cardiovascular diseases. In the current study, we used platelet aggregation ex vivo in platelet-rich plasma induced with arachidonic acid as a routine method for the determination of the individual dose of acetylsalicylic acid necessary to inhibit platelet aggregation in 108 patients with cardiovascular diseases. In 40% of all patients studied, a dose of 30 mg/day was sufficient to block the arachidonic acid-induced platelet aggregation nearly completely. In 50% of all patients, a dose of 100 mg/day was necessary. In 10% of all patients, the dose had to be further increased to 300 mg/day or even to 500 mg/day to inhibit platelet aggregation nearly completely. These results demonstrate that platelet aggregation can be used as a simple routine laboratory method to control acetylsalicylic acid treatment in patients with cardiovascular diseases and to determine individual doses of acetylsalicylic acid for a nearly complete inhibition of platelet aggregation. With a standard dose of 100 mg/day, 10% of the patients were nonresponders. PMID:11441981

  8. ASA's Bachelor's and beyond Survey: Findings and Their Implications for Students and Departments

    Science.gov (United States)

    Spalter-Roth, Roberta; Senter, Mary Scheuer; Stone, Pamela; Wood, Michael

    2010-01-01

    With the support of the National Science Foundation, the American Sociological Association conducted a longitudinal survey of sociology majors from the class of 2005, following them from senior year into careers or graduate school. The first part of this article provides a context for the results from the What Can I Do with a Bachelor's Degree in…

  9. Pengecualian terhadap Penerapan Asas Ultra Petitum Partium dalam Beracara di Pengadilan Agama

    Directory of Open Access Journals (Sweden)

    Mrs. Hartini

    2012-02-01

    Full Text Available A judge must examine and adjudicate all charges thoroughly on the lawsuit brought to the court. The judge should not only examine and adjudicate part of the charge and disregard the rest. On the other hand, judge in his/her adjudication is prohibited to accede above the suit brought by the parties. This prohibition is called ultra petitum partium. A judge who accedes in excess of the suit partium is considered to be exceeding his/her authority. In Religious Court proceedings, the implementation of ultra petitum partium principle is an exception in several types of cases. In the procedure of divorce (cerai talak, a judge may grant something not demanded by wife either in the petition of divorce or in the reconvention by charging certain obligations upon the husband, which is the wife’s right as the consequence of the separation. In the procedure of divorce, judge may order a preliminary injunction even if such injunction is not demanded. The argument that justifies the judge’s action is the Marriage Act and the procedural law in the Act on Religious Court is a lex specialis stipulation, judge as judge made law must dig into the values of life, and the judge may execute contra legem action if the stipulation in an article considered to be in contradiction with justice and benefit.

  10. Role of ASA in the primary and secondary prevention of cardiovascular events.

    NARCIS (Netherlands)

    Casado-Arroyo, R.; Bayrak, F.; Sarkozy, A.; Chierchia, G.B.; Asmundis, C. de; Brugada, P.

    2012-01-01

    Cardiovascular disease, which includes coronary heart disease, cerebrovascular disease and peripheral artery disease, is the leading cause of death in developed countries. Evidence from basic research, clinical investigations, observational epidemiologic studies and randomized clinical trials has pr

  11. Costs Associated with Using the ASA24® Dietary Assessment Tool

    Science.gov (United States)

    As part of its mission to advance measures and methods for monitoring cancer-related behaviors and other risk factors, the Risk Factor Assessment Branch provides tools and resources to the extramural research community.

  12. ASAS Centennial Paper: Net energy systems for beef cattle-Concepts, application, and future models

    Science.gov (United States)

    Development of nutritional energetics can be traced to the 1400’s. Lavoisier established relationships among O2 use, CO2 production and heat production (HP) in the late 1700’s, and the laws of thermodynamics and law of Hess were discovered during the 1840’s. Those discoveries established the fundame...

  13. ASAS Centennial Paper: Developments and future outlook for preharvest food safety

    Science.gov (United States)

    While the United States food supply is one of the safest in the world, CDC estimates that 76 million people get sick, more than 300,000 are hospitalized, and 5,000 die each year from foodborne illness. Consequently, preventing foodborne illness and death remains a major public health concern. Chal...

  14. A sombra das vossas asas: o corpo como rascunho e projeto de si

    Directory of Open Access Journals (Sweden)

    Érica Schlude Wels

    2015-12-01

    Full Text Available Arquiteturas corporais, consumo, alta e baixa cultura e processos de hibridização na hipermodernidade são os temas centrais do recorte teórico do presente artigo, a partir da crítica empreendida por autores como Baudrillard (2004, 2003, 1991, Lipovetsky (2004, Canclini (2003, 1999. Como obra-síntese dessas questões, escolhemos o romance “A sombra das vossas asas” (1997, de Fernanda Young, no qual o corpo da escritora ganha voz no plano narrativo; o enredo se constitui a partir de uma reconstrução corporal da protagonista, com vistas à aparência da modelo Lee Miller. Participam igualmente dessa leitura aspectos midiáticos, presentes também na figura da romancista, além da sedução, proporcionada por uma espécie de projeto pessoal de si mesmo, guiado pela moda e pelo consumo.

  15. PROBLEMATIKA PENERAPAN ASAS RECKLESSNESS DALAM PERSPEKTIF PEMBAHARUAN HUKUM LALU LINTAS DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Edi As'adi

    2014-09-01

    Full Text Available Recklessness is one of the causes of traffic accidents. However, Law No. 22 of 2009 has not implicitly set the application of the principle of recklessness. So in field settings is still referring to the 359 of the Criminal Code, Article 360 of the Criminal Code and Article 492 of the Criminal Code, and even for difficult cases and found no law in the traffic law, judges apply article 338 of the Criminal Code with the principle of dolus eventualis consideration to fill the legal vacuum which are not in traffic law. Based in the future it is necessary reformulation of the principle of Recklessness in traffic law reform based on social justice values of Pancasila.

  16. ASA conference on radiation and health. Coolfont V. Final report. Summaries

    International Nuclear Information System (INIS)

    The conference included presentations on four major topics related to radiation and health: dose assessment, measurement error, dose-response, and dosimetry. Separate abstracts have been prepared for the individual presentations

  17. Vicia faba Hypersensitivity and ASA Intolerance in a Farmer: A Case Report

    Directory of Open Access Journals (Sweden)

    Elisabetta Damiani

    2011-01-01

    Full Text Available The IgE-mediated allergic reactions to food are caused, generally, by ingestion. However, they can be rarely induced by exposure to airborne food particles through the handling or the cooking. Vicia faba is a vegetable which belongs to Legumes or Fabaceae family, Fabales order. Allergic reactions after ingestion of legumes and cases of asthma after exposure to the cooking vapors have been reported in the literature. A paper assessed the volatile substances (insect repellents released by V. faba. The authors demonstrated that this plant produces several chemical substances, such as small quantities of methyl salicylate. We describe a case of occupational allergy, induced by handling during picking up of fresh broad beans, in a farmer with history of adverse reaction after eating the cooked and raw vegetable.

  18. Photo Essay: An East Asian Circulation: Asa Mattice on the USS Juniata, 1883–1885

    Directory of Open Access Journals (Sweden)

    Robert Bickers

    2013-06-01

    Full Text Available On Tuesday, May 12, 1885, 210 men from the U.S. navy warships Juniata and Monocacy marched up Shanghai’s Nanjing Road, from the riverside Bund to the Shanghai racecourse, led by a sixteen-man band. There, on the recreation ground inside the track, they exercised and paraded for two hours, putting their field gun teams through their maneuvers, and in the afternoon the band played for the spectators. The weather was fine that day. Toward the end of the proceedings, before the men were paraded back through the streets of the foreign-run International Settlement to embark for the ships moored in the Huangpu River, the North China Herald (May 15, 1885, p. 552 recorded that “past Assistant Engineer Mattice of the Juniata took a photographic view of the battalion by the dry plate process.”

  19. New Photometrically Variable Magnetic Chemically Peculiar Stars in the ASAS-3 Archive

    CERN Document Server

    Hümmerich, Stefan; Bernhard, Klaus

    2016-01-01

    The magnetic Ap or CP2 stars are natural atomic and magnetic laboratories and ideal testing grounds for the evaluation of model atmospheres. CP2 stars exhibiting photometric variability are traditionally referred to as alpha2 Canum Venaticorum (ACV) variables. Strictly periodic changes are observed in the spectra and brightness of these stars, which allow the derivation of rotational periods. Related to this group of objects are the He-weak (CP4) and He-rich stars, some of which are also known to undergo brightness changes due to rotational modulation. Increasing the sample size of known rotational periods among CP2/4 stars is an important task, which will contribute to our understanding of these objects and their evolution in time. We have compiled an extensive target list of magnetic chemically peculiar (CP2/4) stars. In addition to that, a systematic investigation of early-type (spectral types B/A) variable stars of undetermined type in the International Variable Star Index of the AAVSO (VSX) yielded addit...

  20. A new dipole index of the salinity anomalies of the tropical Indian Ocean.

    Science.gov (United States)

    Li, Junde; Liang, Chujin; Tang, Youmin; Dong, Changming; Chen, Dake; Liu, Xiaohui; Jin, Weifang

    2016-01-01

    With the increased interest in studying the sea surface salinity anomaly (SSSA) of the tropical Indian Ocean during the Indian Ocean Dipole (IOD), an index describing the dipole variability of the SSSA has been pursued recently. In this study, we first use a regional ocean model with a high spatial resolution to produce a high-quality salinity simulation during the period from 1982 to 2014, from which the SSSA dipole structure is identified for boreal autumn. On this basis, by further analysing the observed data, we define a dipole index of the SSSA between the central equatorial Indian Ocean (CEIO: 70°E-90°E, 5°S-5°N) and the region off the Sumatra-Java coast (SJC: 100°E-110°E, 13°S-3°S). Compared with previous SSSA dipole indices, this index has advantages in detecting the dipole signals and in characterizing their relationship to the sea surface temperature anomaly (SSTA) dipole variability. Finally, the mechanism of the SSSA dipole is investigated by dynamical diagnosis. It is found that anomalous zonal advection dominates the SSSA in the CEIO region, whereas the SSSA in the SJC region are mainly influenced by the anomalous surface freshwater flux. This SSSA dipole provides a positive feedback to the formation of the IOD events.

  1. A new dipole index of the salinity anomalies of the tropical Indian Ocean

    Science.gov (United States)

    Li, Junde; Liang, Chujin; Tang, Youmin; Dong, Changming; Chen, Dake; Liu, Xiaohui; Jin, Weifang

    2016-01-01

    With the increased interest in studying the sea surface salinity anomaly (SSSA) of the tropical Indian Ocean during the Indian Ocean Dipole (IOD), an index describing the dipole variability of the SSSA has been pursued recently. In this study, we first use a regional ocean model with a high spatial resolution to produce a high-quality salinity simulation during the period from 1982 to 2014, from which the SSSA dipole structure is identified for boreal autumn. On this basis, by further analysing the observed data, we define a dipole index of the SSSA between the central equatorial Indian Ocean (CEIO: 70°E-90°E, 5°S-5°N) and the region off the Sumatra-Java coast (SJC: 100°E-110°E, 13°S-3°S). Compared with previous SSSA dipole indices, this index has advantages in detecting the dipole signals and in characterizing their relationship to the sea surface temperature anomaly (SSTA) dipole variability. Finally, the mechanism of the SSSA dipole is investigated by dynamical diagnosis. It is found that anomalous zonal advection dominates the SSSA in the CEIO region, whereas the SSSA in the SJC region are mainly influenced by the anomalous surface freshwater flux. This SSSA dipole provides a positive feedback to the formation of the IOD events. PMID:27052319

  2. A new dipole index of the salinity anomalies of the tropical Indian Ocean

    Science.gov (United States)

    Li, Junde; Liang, Chujin; Tang, Youmin; Dong, Changming; Chen, Dake; Liu, Xiaohui; Jin, Weifang

    2016-04-01

    With the increased interest in studying the sea surface salinity anomaly (SSSA) of the tropical Indian Ocean during the Indian Ocean Dipole (IOD), an index describing the dipole variability of the SSSA has been pursued recently. In this study, we first use a regional ocean model with a high spatial resolution to produce a high-quality salinity simulation during the period from 1982 to 2014, from which the SSSA dipole structure is identified for boreal autumn. On this basis, by further analysing the observed data, we define a dipole index of the SSSA between the central equatorial Indian Ocean (CEIO: 70°E-90°E, 5°S-5°N) and the region off the Sumatra-Java coast (SJC: 100°E-110°E, 13°S-3°S). Compared with previous SSSA dipole indices, this index has advantages in detecting the dipole signals and in characterizing their relationship to the sea surface temperature anomaly (SSTA) dipole variability. Finally, the mechanism of the SSSA dipole is investigated by dynamical diagnosis. It is found that anomalous zonal advection dominates the SSSA in the CEIO region, whereas the SSSA in the SJC region are mainly influenced by the anomalous surface freshwater flux. This SSSA dipole provides a positive feedback to the formation of the IOD events.

  3. The role of multi-parametric MR imaging in the detection of early inflammatory sacroiliitis according to ASAS criteria

    International Nuclear Information System (INIS)

    Purpose: To retrospectively evaluate the accuracy of multi-parametric magnetic resonance (MR) imaging including fat saturated (FS) T2-weighted, short-tau inversion recovery (STIR), diffusion-weighted (DW-MR), and dynamic-contrast-enhanced MR (DCE-MR) imaging techniques in the diagnosis of early inflammatory sacroiliitis and determine the additional value of DW-MR and DCE-MR images according to recently defined ‘Assessment in SpondyloArthritis international Society’ criteria. Materials and methods: The study included 45 patients with back pain. Two radiologists estimated the likelihood of osteitis in 4 independent viewing sessions including FS T2-weighted, STIR, DW-MR and DCE-MR images. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic (ROC) curve (AUC) were calculated. Results: Of the 45 patients, 31 had inflammatory back pain. Of 31, 28 (90.3%) patients had inflammatory sacroiliitis diagnosed by clinical and laboratory analysis. FS T2-weighted MR images had the highest sensitivity (42.8% for both radiologists) for detecting osteitis in patients with inflammaory sacroiliitis when compared to other imaging sequences. For specificity, PPV, NPV, accuracy, and AUC levels there were no statistically significant difference between image viewing settings. However, adding STIR, DW-MR and DCE-MR images to the FS T2-weighted MR images did not improve the above stated indices. Conclusion: FS T2-weighted MR imaging had the highest sensitivity when compared to other imaging sequences. The addition of DW-MR and DCE-MR images did not significantly improve the diagnostic value of MR imaging in the diagnosis of osteitis for both experienced and less experienced radiologists

  4. The role of multi-parametric MR imaging in the detection of early inflammatory sacroiliitis according to ASAS criteria

    Energy Technology Data Exchange (ETDEWEB)

    Boy, Fatma Nur, E-mail: nursoylu@yahoo.com [Department of Radiology, Fatih Sultan Mehmet Training and Research Hospital, E-5 Karayolu Uzeri, 34752 Atasehir, Istanbul (Turkey); Kayhan, Arda, E-mail: arda_kayhan@yahoo.com [Health Services Vocational School, Esenyurt University, Dogan Arasli Bulvari No 120, Esenyurt, Istanbul (Turkey); Karakas, Hakki Muammer, E-mail: hakki.karakas@gmail.com [Department of Radiology, Fatih Sultan Mehmet Training and Research Hospital, E-5 Karayolu Uzeri, 34752 Atasehir, Istanbul (Turkey); Unlu-Ozkan, Feyza, E-mail: feyzamd@yahoo.com [Department of Physical Therapy and Rehabilitation, Fatih Sultan Mehmet Training and Research Hospital, E-5 Karayolu Uzeri, 34752 Atasehir, Istanbul (Turkey); Silte, Duygu, E-mail: drduygusilte@hotmail.com [Department of Physical Therapy and Rehabilitation, Fatih Sultan Mehmet Training and Research Hospital, E-5 Karayolu Uzeri, 34752 Atasehir, Istanbul (Turkey); Aktas, İlknur, E-mail: iaktas@hotmail.com [Department of Physical Therapy and Rehabilitation, Fatih Sultan Mehmet Training and Research Hospital, E-5 Karayolu Uzeri, 34752 Atasehir, Istanbul (Turkey)

    2014-06-15

    Purpose: To retrospectively evaluate the accuracy of multi-parametric magnetic resonance (MR) imaging including fat saturated (FS) T2-weighted, short-tau inversion recovery (STIR), diffusion-weighted (DW-MR), and dynamic-contrast-enhanced MR (DCE-MR) imaging techniques in the diagnosis of early inflammatory sacroiliitis and determine the additional value of DW-MR and DCE-MR images according to recently defined ‘Assessment in SpondyloArthritis international Society’ criteria. Materials and methods: The study included 45 patients with back pain. Two radiologists estimated the likelihood of osteitis in 4 independent viewing sessions including FS T2-weighted, STIR, DW-MR and DCE-MR images. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic (ROC) curve (AUC) were calculated. Results: Of the 45 patients, 31 had inflammatory back pain. Of 31, 28 (90.3%) patients had inflammatory sacroiliitis diagnosed by clinical and laboratory analysis. FS T2-weighted MR images had the highest sensitivity (42.8% for both radiologists) for detecting osteitis in patients with inflammaory sacroiliitis when compared to other imaging sequences. For specificity, PPV, NPV, accuracy, and AUC levels there were no statistically significant difference between image viewing settings. However, adding STIR, DW-MR and DCE-MR images to the FS T2-weighted MR images did not improve the above stated indices. Conclusion: FS T2-weighted MR imaging had the highest sensitivity when compared to other imaging sequences. The addition of DW-MR and DCE-MR images did not significantly improve the diagnostic value of MR imaging in the diagnosis of osteitis for both experienced and less experienced radiologists.

  5. PERLINDUNGAN HUKUM BAGI PEMOHON KREDIT DENGAN MENGACU PADA ASAS KESEIMBANGAN ANTARA PELAKU USAHA (BANK DAN KONSUMENNYA (PEMOHON KREDIT

    Directory of Open Access Journals (Sweden)

    Ni Luh Putu Sri Suryaningsih

    2012-10-01

    Full Text Available Banking institutions as one of the financial institutions have a strategic rolein supporting the economic life of a country. Banking institutions meant hereas an intermediary of the parties who have surplus funds to the lack of funds.Banking activities that provide services on the economic sector that do not inspite of the risks that could harm the banks themselves and the customer.Relationship between the bank and the customer is bound to a creditagreement unnoticed by the debtor of his rights is often overlooked by thebank. Guaranteeing the law protection and law certainty for the debtorslosing for such unilateral, the regulations of consumer protection, therefore,have important functions. The type of research used in this paper is thenormative legal research. This research moved from the inclusion of thestandard clause that would open up opportunities for businesses, especiallybanks to position the client, in this case the credit applicant, to be weakerthan the bank.

  6. The STRESA (storage of reactor safety) database (Web page: http://asa2.jrc.it/stresa)

    Energy Technology Data Exchange (ETDEWEB)

    Annunziato, A.; Addabbo, C.; Brewka, W. [Joint Research Centre, Commission of the European Communities, Ispra (Italy)

    2001-07-01

    A considerable amount of resources has been devoted at the international level during the last few decades, to the generation of experimental databases in order to provide reference information for the understanding of reactor safety relevant phenomenologies and for the development and/or assessment of related computational methodologies. The extent to which these databases are preserved and can be accessed and retrieved is an issue of major concern. This paper provides an outline of the JRC databases preservation initiative and a description of the supporting web-based computer platform STRESA. (author)

  7. The expansion of low cost carriers into the long-haul market: a strategic analysis of Norwegian Air Shuttle ASA

    OpenAIRE

    Chen, Long; Pawlikowski, Hubert

    2015-01-01

    The low-cost carrier (“LCC”) business model has been in existence for several decades and their market share has been growing steadily. However, the most successful LCCs such as Southwest, Ryanair and EasyJet have focused upon implementing the low-cost strategy on short-haul routes. The main strategic objective of this thesis is to identify the underlying reasons for this phenomenon and whether there is a potential for the exploitation of the low-cost business model on long-haul ...

  8. Historical Highlights From 75 Years of the Soil Science Society of America

    Science.gov (United States)

    Brevik, E. C.

    2012-04-01

    From its official founding on November 18, 1936 to the present day, the Soil Science Society of America (SSSA) has developed a rich and diverse history. SSSA began with 190 members grouped into six sections: 1) physics, 2) chemistry, 3) microbiology, 4) fertility, 5) morphology, and 6) technology. Today SSSA has over 6,000 members who can choose from any of 11 divisions, S1 Soil Physics, S2 Soil Chemistry, S3 Soil Biology and Biochemistry, S4 Soil Fertility and Plant Nutrition, S5 Pedology, S6 Soil and Water Management and Conservation, S7 Forest, Range, and Wildland Soils, S8 Nutrient Management and Soil and Plant Analysis, S9 Soil Mineralogy, S10 Wetland Soils, and S11 Soils and Environmental Quality to represent their primary area(s) of interest. The Society has also gone from being largely agriculturally focused to an eclectic mix of individuals with interests in agriculture, the environment, earth sciences, human interactions, and other diverse areas. At its founding, SSSA sponsored one publication, the Soil Science Society of America Proceedings. Today, SSSA sponsors its descendent, the Soil Science Society of America Journal, as well as Vadose Zone Journal, the Journal of Environmental Quality, Soil Survey Horizons, and the Journal of Natural Resources and Life Science Education. In short, SSSA's history has been one of continued growth over the last 75 years. The future holds many challenges for SSSA and the field of soil science. There are increasing calls to meet with groups other than or in addition to the American Society of Agronomy and the Crop Science Society of America, groups like the Geological Society of America and the Ecological Society of America. Members in SSSA now work in university departments, government agencies, and businesses representing the fields of biology, geology, geography, and archeology, among others, in addition to the traditional agricultural sector. How SSSA handles this diversification of the field and its membership will

  9. Asas da Norma: o míto de Ícaro e o positivismo jurídico de Hans Kelsen

    Directory of Open Access Journals (Sweden)

    Rafael Henrique Pereira

    2013-12-01

    Full Text Available Estabelece uma paridade entre o positivismo jurídico de Hans Kelsen, com foco na obra filosófica “Teoria Pura do Direito”, e o mito de Ícaro, consagrado na mitologia grega, cujos erros e acertos verificados no instituto positivista, especificamente, durante o período compreendido na Segunda Guerra Mundial, legitimou, ainda que indiretamente, a ascensão do pensamento e poder ditatorial hitleriano.

  10. What can be done to increase the value of Statoil ASA? Analysis of the discrepancy between theoretical value and stock price

    OpenAIRE

    Guevara, Susana

    2014-01-01

    The trend of Statoil’s stock price has remained flat over the course of the last few years, gaining the attention of investors and managers and creating doubts among them as to whether Statoil’s shares are correctly priced on the market. The intention of this thesis is to find a theoretical value of Statoil’s share and compare it with its market price in order to find any discrepancy. For this purpose, three different valuation methods were utilized; Market Comparables method, ...

  11. CHARACTERIZING A DRAMATIC ΔV ∼ –9 FLARE ON AN ULTRACOOL DWARF FOUND BY THE ASAS-SN SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Sarah J.; Stanek, K. Z.; Shappee, Benjamin J.; Kochanek, C. S.; Jencson, J.; Holoien, T. W.-S.; Basu, U.; Beacom, John F. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Prieto, Jose L. [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Peyton Hall, Princeton, NJ 08544 (United States); Morrell, Nidia [Las Campanas Observatory, Carnegie Observatories, Casilla 601, La Serena (Chile); Bardalez Gagliuffi, Daniella C. [Center for Astrophysics and Space Science, University of California San Diego, La Jolla, CA 92093 (United States); Szczygieł, D. M.; Pojmanski, G. [Warsaw University Astronomical Observatory, Al. Ujazdowskie 4, 00-478 Warsaw (Poland); Brimacombe, J. [Coral Towers Observatory, Cairns, Queensland 4870 (Australia); Dubberley, M.; Elphick, M.; Foale, S.; Hawkins, E.; Mullins, D.; Rosing, W., E-mail: schmidt@astronomy.ohio-state.edu [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); and others

    2014-02-01

    We analyze a ΔV ∼ –9 magnitude flare on the newly identified M8 dwarf SDSS J022116.84+194020.4 (hereafter SDSSJ0221) detected as part of the All-Sky Automated Survey for Supernovae. Using infrared and optical spectra, we confirm that SDSSJ0221 is a relatively nearby (d ∼ 76 pc) M8 dwarf with strong quiescent Hα emission. Based on kinematics and the absence of features consistent with low-gravity (young) ultracool dwarfs, we place a lower limit of 200 Myr on the age of SDSSJ0221. When modeled with a simple, classical flare light curve, this flare is consistent with a total U-band flare energy E{sub U} ∼ 10{sup 34} erg, confirming that the most dramatic flares are not limited to warmer, more massive stars. Scaled to include a rough estimate of the emission line contribution to the V band, we estimate a blackbody filling factor of ∼10%-30% during the flare peak and ∼0.5%-1.6% during the flare decay phase. These filling factors correspond to flare areas that are an order of magnitude larger than those measured for most mid-M dwarf flares.

  12. O ENSINO COM GÊNEROS TEXTUAIS NO PROGRAMA DE ACELERAÇÃO DA APRENDIZAGEM ASAS DA FLORESTANIA – ACRE

    Directory of Open Access Journals (Sweden)

    José Júlio César do Nascimento Araújo

    2011-12-01

    Full Text Available This article shows how you performed the teaching of writing in the classroom in the Wings Program Florestania acceleration in rural public schools of the Southern Cross-Acre. The central focus is directed at the relationship between cognition, building concepts and strategies of representation of information through genres. It is understood by speech genres, in this proposal, the superstructures. The work was developed based on qualitative methodology and its theoretical framework, especially the postulates VanDijk, (2004, Lopes-Rossi (2002 and Fairclough (2001. They want to expand the question: is that when teachers set out the names of discourse genres or genre or text types, are meaning the same theoretical object? Thus, it is necessary first of all, understand what you are addressing in Portuguese classes in the program Wings of Florestania, and what peculiarities in each different comprehensive approach. The texts were collected from classroom activities by teachers Florestania Wings of the Program on Southern Cross / AC. In analyzing the texts and the results have worked to see that the way the teachers guide the discursive practices of their students in relation to multimodal texts and this work contributes to building a critical discourse of the student, and also what are the guidelines regarding the many functions and meanings of Literacy, underlying the discursive practices used by teachers. Wanted, finally, to understand how the genres are worked in the classroom in an Amazonian community.

  13. Evaluación preliminar de actividad insecticida de lectina ASA II a partir de ajo (Allium sativum), sobre Tecia solanivora

    OpenAIRE

    Carreño Rondón, Nury Lysseth

    2013-01-01

    La polilla guatemalteca de la papa Tecia solanivora es considerada como uno de los principales insectos que ataca el cultivo de papa, causando daños a los tubérculos tanto en campo como en almacenamiento, existen reportes en Colombia que mencionan pérdidas cercanas al 25% en cultivo y hasta el 100% en almacenamiento. El uso de plaguicidas químicos es generalmente la única forma de control del insecto, sin embargo el uso de plaguicidas puede ocasionar efectos tóxicos sobre el cultivo y sobre e...

  14. Dicty_cDB: SSA649 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA649 (Link to dictyBase) - - - Contig-U14313-1 SSA649Z (Link... to Original site) - - SSA649Z 355 - - - - Show SSA649 Library SS (Link to library) Clone ID SSA649 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA6-C/SSA649Q.Seq.d/ Representative seq. ID SSA64...9Z (Link to Original site) Representative DNA sequence >SSA649 (SSA649Q) /CSM/SS/SSA6-C/SSA649Q.Seq.d/ XXXXX...SM-cDNA Score E Sequences producing significant alignments: (bits) Value SSA649 (SSA649Q) /CSM/SS/SSA6-C/SSA

  15. Dicty_cDB: SSA871 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA871 (Link to dictyBase) - - - Contig-U15063-1 SSA871P (Link to Original site) SSA...871F 197 SSA871Z 507 SSA871P 704 - - Show SSA871 Library SS (Link to library) Clone ID SSA... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA8-C/SSA871Q.Seq.d/ Representative seq. ID SSA...871P (Link to Original site) Representative DNA sequence >SSA871 (SSA871Q) /CSM/SS/SSA8-C/SSA8...ng significant alignments: (bits) Value SSA871 (SSA871Q) /CSM/SS/SSA8-C/SSA871Q.Seq.d/ 1176 0.0 CHD325 (CHD3

  16. Dicty_cDB: SSA153 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA153 (Link to dictyBase) - - - Contig-U10248-1 SSA153F (Link to Original site) SSA...153F 463 - - - - - - Show SSA153 Library SS (Link to library) Clone ID SSA153 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA1-C/SSA153Q.Seq.d/ Representative seq. ID SSA15...3F (Link to Original site) Representative DNA sequence >SSA153 (SSA153Q) /CSM/SS/SSA1-C/SSA153Q.Seq.d/ ATTTG...ficant alignments: (bits) Value SSA153 (SSA153Q) /CSM/SS/SSA1-C/SSA153Q.Seq.d/ 918 0.0 SSH468 (SSH468Q) /CSM

  17. Dicty_cDB: SSA863 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA863 (Link to dictyBase) - - - Contig-U14496-1 - (Link to Original site) - - SSA...863Z 436 - - - - Show SSA863 Library SS (Link to library) Clone ID SSA863 (Link to dicty...iol.tsukuba.ac.jp/CSM/SS/SSA8-C/SSA863Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >SSA863 (SSA863Q) /CSM/SS/SSA8-C/SSA863Q.Seq.d/ XXXXXXXXXXAGATTCA...ore E Sequences producing significant alignments: (bits) Value SSA863 (SSA863Q) /CSM/SS/SSA8-C/SSA863Q.Seq.d

  18. Dicty_cDB: SSA452 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA452 (Link to dictyBase) - G20763 DDB0185811 Contig-U04397-1... - (Link to Original site) SSA452F 433 - - - - - - Show SSA452 Library SS (Link to library) Clone ID SSA452 ...l site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA4-C/SSA452Q.Seq.d/ Repres...entative seq. ID - (Link to Original site) Representative DNA sequence >SSA452 (SSA452Q) /CSM/SS/SSA4-C/SSA4...ng significant alignments: (bits) Value SSA452 (SSA452Q) /CSM/SS/SSA4-C/SSA452Q.Seq.d/ 383 e-105 SLD553 (SLD

  19. Dicty_cDB: SSA362 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA362 (Link to dictyBase) - - - Contig-U16560-1 SSA362Z (Link... to Original site) - - SSA362Z 549 - - - - Show SSA362 Library SS (Link to library) Clone ID SSA362 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA3-C/SSA362Q.Seq.d/ Representative seq. ID SSA36...2Z (Link to Original site) Representative DNA sequence >SSA362 (SSA362Q) /CSM/SS/SSA3-C/SSA362Q.Seq.d/ XXXXX...es producing significant alignments: (bits) Value SSA362 (SSA362Q) /CSM/SS/SSA3-C/SSA362Q.Seq.d/ 1027 0.0 SS

  20. Dicty_cDB: SSA472 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA472 (Link to dictyBase) - - - Contig-U01956-1 SSA472F (Link to Original site) SSA...472F 540 - - - - - - Show SSA472 Library SS (Link to library) Clone ID SSA472 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA4-C/SSA472Q.Seq.d/ Representative seq. ID SSA47...2F (Link to Original site) Representative DNA sequence >SSA472 (SSA472Q) /CSM/SS/SSA4-C/SSA472Q.Seq.d/ TAAAA... 854 0.0 SSC507 (SSC507Q) /CSM/SS/SSC5-A/SSC507Q.Seq.d/ 854 0.0 SSA650 (SSA650Q) /CSM/SS/SSA6-C/SSA650Q.Seq.d/ 854 0.0 SSA472 (SSA

  1. Dicty_cDB: SSA449 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA449 (Link to dictyBase) - - - Contig-U12270-1 SSA449E (Link... to Original site) - - - - - - SSA449E 372 Show SSA449 Library SS (Link to library) Clone ID SSA449 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA4-C/SSA449Q.Seq.d/ Representative seq. ID SSA44...9E (Link to Original site) Representative DNA sequence >SSA449 (SSA449Q) /CSM/SS/SSA4-C/SSA449Q.Seq.d/ TAAAC...*ilkk kkk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSA449 (SSA449Q) /CSM/SS/SSA4-C/SSA

  2. Dicty_cDB: SSA563 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA563 (Link to dictyBase) - - - - SSA563E (Link to Original site) - - - - - - SSA...563E 383 Show SSA563 Library SS (Link to library) Clone ID SSA563 (Link to dictyBase) At...las ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA5-C/SSA...563Q.Seq.d/ Representative seq. ID SSA563E (Link to Original site) R...epresentative DNA sequence >SSA563 (SSA563Q) /CSM/SS/SSA5-C/SSA563Q.Seq.d/ GATTCAGAAAAAATTAAAAAAGCCAGAGATTTT

  3. Dicty_cDB: SSA249 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available utative transporter protein SSA662 (ssa662) mRNA, complete cds. 40 9e-04 2 AC1155...SS (Link to library) SSA249 (Link to dictyBase) - - - Contig-U07966-1 - (Link to Original site) SSA...249F 236 - - - - - - Show SSA249 Library SS (Link to library) Clone ID SSA249 (Link to dicty...iol.tsukuba.ac.jp/CSM/SS/SSA2-C/SSA249Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >SSA249 (SSA249Q) /CSM/SS/SSA2-C/SSA249Q.Seq.d/ ACTTATCGTCACAATTC

  4. Dicty_cDB: SSA770 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA770 (Link to dictyBase) - - - - SSA770F (Link to Original site) SSA...770F 172 - - - - - - Show SSA770 Library SS (Link to library) Clone ID SSA770 (Link to dictyBase) At...las ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA7-C/SSA...770Q.Seq.d/ Representative seq. ID SSA770F (Link to Original site) R...epresentative DNA sequence >SSA770 (SSA770Q) /CSM/SS/SSA7-C/SSA770Q.Seq.d/ ATTTATTCTTTATCGAATATCATAATTAAAAGA

  5. ON THE 125TH ANNIVERSARY OF ACETYLSALICYLIC ACID

    Directory of Open Access Journals (Sweden)

    I. N. Bokarev

    2011-01-01

    Full Text Available An experience of acetylsalicylic acid (ASA clinical use since its synthesis in 1887 is highlighted. ASA modes of action and its position among the modern antiplatelet agents are considered. The evidence based clinical data on ASA treatment and the problem of antiplatelet therapy resistance are discussed. ASA interaction with other drugs and ASA pleiotropic effects are reviewed 

  6. Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system

    Directory of Open Access Journals (Sweden)

    Xie YT

    2012-06-01

    Full Text Available Yi-Ting Xie, Yong-Zhong Du, Hong Yuan, Fu-Qiang HuCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaPurpose: Therapy for central nervous system disease is mainly restricted by the blood–brain barrier. A drug-delivery system is an effective approach to overcome this barrier. In this research, the potential of polymeric micelles for brain-targeting drug delivery was studied.Methods: Stearic acid–grafted chitosan (CS-SA was synthesized by hydrophobic modification of chitosan with stearic acid. The physicochemical characteristics of CS-SA micelles were investigated. bEnd.3 cells were chosen as model cells to evaluate the internalization ability and cytotoxicity of CS-SA micelles in vitro. Doxorubicin (DOX, as a model drug, was physically encapsulated in CS-SA micelles. The in vivo brain-targeting ability of CS-SA micelles was qualitatively and quantitatively studied by in vivo imaging and high-performance liquid chromatography analysis, respectively. The therapeutic effect of DOX-loaded micelles in vitro was performed on glioma C6 cells.Results: The critical micelle concentration of CS-SA micelles with 26.9% ± 1.08% amino substitute degree was 65 µg/mL. The diameter and surface potential of synthesized CS-SA micelles in aqueous solution was 22 ± 0.98 nm and 36.4 ± 0.71 mV, respectively. CS-SA micelles presented excellent cellular uptake ability on bEnd.3 cells, the IC50 of which was 237.6 ± 6.61 µg/mL. DOX-loaded micelles exhibited slow drug-release behavior, with a cumulative release up to 72% within 48 hours in vitro. The cytotoxicity of DOX-loaded CS-SA micelles against C6 was 2.664 ± 0.036 µg/mL, compared with 0.181 ± 0.066 µg/mL of DOX • HCl. In vivo imaging results indicated that CS-SA was able to transport rapidly across the blood–brain barrier and into the brain. A maximum DOX distribution in brain of 1.01%/g was observed 15 minutes after administration and maintained above 0.45%/g within 1 hour

  7. The beneficial effect of methylphenidate in ADHD with comorbid separation anxiety.

    Science.gov (United States)

    Golubchik, Pavel; Golubchik, Lilya; Sever, Jonathan M; Weizman, Abraham

    2014-09-01

    The objective of this study was to assess the response of subsyndromal separation anxiety (SSSA) symptoms to methylphenidate (MPH) treatment in patients with attention-deficit/hyperactivity disorder (ADHD). A group of patients with ADHD and SSSA (n=42), aged 8-17 years, received 12 weeks of MPH treatment. The severity of SSSA symptoms was assessed using appropriate scales including the Screen for Child Anxiety Related Emotional Disorders and the specially designed Child and Adolescent Separation Anxiety Scale (CASAS). The severity of ADHD symptoms was assessed using the ADHD Rating Scale. The severity of ADHD and separation anxiety reduced significantly and significant positive correlations were found between the changes in ADHD Rating Scale and the total CASAS scores (P=0.012), as well as other relevant subscales of Screen for Child Anxiety Related Emotional Disorders and CASAS. The MPH-related attenuation in the severity of ADHD was associated with a corresponding improvement in separation anxiety related to school. SSSA symptomatology may be secondary to ADHD and thus the alleviation in ADHD symptoms achieved by MPH treatment results in corresponding relief in separation anxiety.

  8. Soil Carbon Sequestration and the Greenhouse Effect (2nd Edition)

    Science.gov (United States)

    This volume is a second edition of the book “Soil Carbon Sequestration and The Greenhouse Effect”. The first edition was published in 2001 as SSSA Special Publ. #57. The present edition is an update of the concepts, processes, properties, practices and the supporting data. All chapters are new co...

  9. Soil and water conservation: Our history and future challenges

    Science.gov (United States)

    Remembering our past is an essential first step into the future. Building upon that philosophy, our objective is to summarize two presentations from a 2012 Soil Science Society of America (SSSA) symposium focused on soil management challenges in response to climate change in order to examine: (1) ho...

  10. Parallel phase 1 clinical trials inthe US andin China:accelerating the test ofavitinib inlung cancer asa novel inhibitor selectively targeting mutated EGFR andovercoming T790M-induced resistance

    Institute of Scientific and Technical Information of China (English)

    Xiao Xu

    2015-01-01

    Avitinib, a new generation inhibitor of epidermal growth factor receptor (EGFR), was approved for clinical trial in both China and the United States, and the phase 1 trials were initiated in both countries in parallel. In the preclinical stud-ies, avitinib showed three novel features including (1) irreversibly bindingEGFR by forming a covalent bound with Cys 797 in the ATP-binding pocket, (2) sparing wild-typeEGFR, and (3) overcoming T790M-induced resistance. Avitinib is the ifrst China-developed novel EGFR inhibitor that has entered in global clinical trials, and will provide a precision targeted therapy for non-small cell lung cancer patients.

  11. Skrajšanje nastavitvenega časa na štiristranskem skobeljnem stroju z metodo SMED: Setup time reduction on four-side planing machine with the SMED method:

    OpenAIRE

    Kropivšek, Jože; Lipušček, Igor; Oblak, Leon

    2003-01-01

    Due to the rapidly increasing diversity of products and smaller batch sizes, the setup time reduction is of crucial importance for the profitability of a company. The article deals with the problem of long setup times in a wood company and possibilities for the solution with the SMED method. On a practical case, the setup time reduction on four-side planing machine was analysed. Zaradi čedalje hitrejšega naraščanja raznolikosti proizvodov in manjšanja velikosti izdelavnih serij je skrajšan...

  12. Energy- and time-saving low-temperature thermomechanical treatment of low-carbon plain steel: Prihranki energije in časa pri nizkotemperaturni termomehanski obdelavi maloogljičnega ploščatega jekla:

    OpenAIRE

    Hauserova, Daniela; Jirkova, Hana; Kucerova, Ludmila; Masek, Bohuslav

    2013-01-01

    Reduction of energy is one way of cutting the cost of finished steel products. In this context heat treatment is a costly stage of the production. This paper presents a method of reducing soft-annealing times. The method termed as ASR (accelerated spheroidization and refinement) was employed for improving the cold formability of the ferrite-pearlite steel. In this study, plain low-carbon RSt-32 steel was used as the experimental material. The influence of deformation below the Asub{c1} temper...

  13. The promising future of agriculture

    Science.gov (United States)

    I was fortunate to take two exciting trips on behalf of CSSA recently – one was to Beijing, China and the other to St. Louis, Missouri. While these were extremely distinct venues and very different meetings, a common thread was that both gave an insight into the future of agriculture. And I believ...

  14. Comparison on the Developmental Trends between Chinese Students Studying Abroad and Foreign Students Studying in China

    Science.gov (United States)

    Liu, Xuezhi

    2014-01-01

    China has been undergoing a new period of political stability, cultural prosperity, and social harmony since its reform and opening-up in the late 1970s. At the same time, the number of Chinese students studying abroad (CSSA) and foreign students studying in China (FSSC) has grown rapidly and steadily in the past three decades. With China's…

  15. [Nutrient contents and heavy metal pollutions in composted sewage sludge from different municipal wastewater treatment plants in Beijing region].

    Science.gov (United States)

    Bai, Li-Ping; Qi, Hong-Tao; Fu, Ya-Ping; Li, Ping

    2014-12-01

    Changes of nutrient contents and heavy metal pollutions in composted sewage sludge from different municipal wastewater treatment plants (as represented by CSS-A and CSS-B, respectively) in Beijing region were investigated. The results showed that the pH values, nutrient contents, trace elements and heavy metals in CSS-A and CSS-B depended on the sludge resources and particular years. The average of organic matter content in different years (203 338.0 mg x kg(-1)) from CSS-A met both the requirement of sludge quality standard for agricultural use (CJ/T 309-2009) and land improvement (GB/T 24600-2009) in China except the permitted limit of sludge quality standards for garden or park use (GB/T 23486-2009) in China. Moreover, the average of organic matter in different years (298531.5 mg x kg(-1)) from CSS-B and the averages of pH values (7.1 and 7.2, respectively) and NPK concentrations (41 111.7 mg x kg(-1) and 65 901.5 mg x kg(-1), respectively) in different years from CSS-A and CSS-B all met the requirements of sludge quality standards for the above-mentioned disposal types of sewage sludge from municipal wastewater treatment plants. The contents of heavy metals in CSS-A and CSS-B except Hg and Ni were below the permitted limits of the A-class sludge quality standard for agricultural use (CJ/T 309-2009) , being the most stringent standards in China. It was suggested that composted sewage sludge from different municipal wastewater treatment plants in Beijing region use as a fertilizer in agriculture, land improvement, and garden or park, but the top concern about potential environmental pollution of Hg and Ni should be considered. PMID:25826937

  16. Identification of oxidation products of 5-aminosalicylic acid in faeces and the study of their formation in vitro

    DEFF Research Database (Denmark)

    Jensen, J.; Cornett, Claus; Olsen, C. E.;

    1993-01-01

    products of 5-ASA using H-1-NMR spectroscopy and mass spectrometry. Reactions carried out in vitro between 5-ASA and oxidants suggested to be present in the inflamed bowel verified that the hypochlorite-mediated oxidation of 5-ASA as well as the haemoglobin-catalysed H2O2-dependent oxidation of 5-ASA...

  17. Positional Isomers of Aspirin Are Equally Potent in Inhibiting Colon Cancer Cell Growth: Differences in Mode of Cyclooxygenase Inhibition

    OpenAIRE

    Kodela, Ravinder; Chattopadhyay, Mitali; Goswami, Satindra; Gan, Zong Yuan; Rao, Praveen P.N.; Nia, Kamran V.; Velázquez-Martínez, Carlos A.; Kashfi, Khosrow

    2013-01-01

    We compared the differential effects of positional isomers of acetylsalicylic acid (o-ASA, m-ASA, and p-ASA) on cyclooxygenase (COX) inhibition, gastric prostaglandin E2 (PGE2), malondialdehyde, tumor necrosis factor-alpha (TNF-α) levels, superoxide dismutase (SOD) activity, human adenocarcinoma colon cancer cell growth inhibition, cell proliferation, apoptosis, and cell-cycle progression. We also evaluated the gastric toxicity exerted by ASA isomers. All ASA isomers inhibit COX enzymes, but ...

  18. Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration

    Science.gov (United States)

    Kawashima, Kousaku; Ishihara, Shunji; Yuki, Takafumi; Onishi, Koji; Kushiyama, Yoshinori; Miyaoka, Youichi; Yuki, Mika; Komazawa, Yoshinori; Tanimura, Takashi; Sonoyama, Hiroki; Tada, Yasumasa; Kusunoki, Ryusaku; Fukuba, Nobuhiko; Oshima, Naoki; Moriyama, Ichiro; Kinoshita, Yoshikazu

    2014-01-01

    Purpose. Few reports have compared the clinical efficacy of a pH-dependent release formulation of mesalazine (pH-5-ASA) with a time-dependent release formulation (time-5-ASA). We examined whether pH-5-ASA is effective for active ulcerative colitis (UC) in patients resistant to time-5-ASA. Methods. We retrospectively and prospectively analyzed the efficacy of pH-5-ASA in mildly to moderately active UC patients in whom time-5-ASA did not successfully induce or maintain remission. The clinical efficacy of pH-5-ASA was assessed by clinical activity index (CAI) before and after switching from time-5-ASA. In addition, the efficacy of pH-5-ASA on mucosal healing (MH) was evaluated in a prospective manner by measuring fecal calprotectin concentration. Results. Thirty patients were analyzed in a retrospective manner. CAI was significantly reduced at both 4 and 8 weeks after switching to pH-5-ASA. In the prospective study (n = 14), administration of pH-5-ASA also significantly reduced CAI scores at 4 and 8 weeks in these patients who were resistant to time-5-ASA. In addition, fecal calprotectin concentration was significantly decreased along with improvement in CAI after switching to pH-5-ASA. Conclusions. Our results suggest that pH-5-ASA has clinical efficacy for mildly to moderately active patients with UC in whom time-5-ASA did not successfully induce or maintain remission. PMID:25478568

  19. Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration

    Directory of Open Access Journals (Sweden)

    Kousaku Kawashima

    2014-01-01

    Full Text Available Purpose. Few reports have compared the clinical efficacy of a pH-dependent release formulation of mesalazine (pH-5-ASA with a time-dependent release formulation (time-5-ASA. We examined whether pH-5-ASA is effective for active ulcerative colitis (UC in patients resistant to time-5-ASA. Methods. We retrospectively and prospectively analyzed the efficacy of pH-5-ASA in mildly to moderately active UC patients in whom time-5-ASA did not successfully induce or maintain remission. The clinical efficacy of pH-5-ASA was assessed by clinical activity index (CAI before and after switching from time-5-ASA. In addition, the efficacy of pH-5-ASA on mucosal healing (MH was evaluated in a prospective manner by measuring fecal calprotectin concentration. Results. Thirty patients were analyzed in a retrospective manner. CAI was significantly reduced at both 4 and 8 weeks after switching to pH-5-ASA. In the prospective study (n=14, administration of pH-5-ASA also significantly reduced CAI scores at 4 and 8 weeks in these patients who were resistant to time-5-ASA. In addition, fecal calprotectin concentration was significantly decreased along with improvement in CAI after switching to pH-5-ASA. Conclusions. Our results suggest that pH-5-ASA has clinical efficacy for mildly to moderately active patients with UC in whom time-5-ASA did not successfully induce or maintain remission.

  20. Barium titanate core – gold shell nanoparticles for hyperthermia treatments

    OpenAIRE

    FarrokhTakin E; Ciofani G; Puleo GL; de Vito G; Filippeschi C; Mazzolai B; Piazza V; Mattoli V

    2013-01-01

    Elmira FarrokhTakin,1,2 Gianni Ciofani,1 Gian Luigi Puleo,1 Giuseppe de Vito,3,4 Carlo Filippeschi,1 Barbara Mazzolai,1 Vincenzo Piazza,3 Virgilio Mattoli1 1Center for Micro-BioRobotics @SSSA, Fondazione Istituto Italiano di Tecnologia, Pontedera, Pisa, Italy; 2The Biorobotics Institute, Scuola Superiore Sant'Anna, Pontedera, Pisa, Italy; 3Center for Nanotechnology Innovation @NEST, Fondazione Istituto Italiano di Tecnologia, Pisa, Italy; 4NEST, Scuola Normale Superiore, Pisa, Italy ...

  1. A new iterative approach to the corrective security-constrained optimal power flow problem

    OpenAIRE

    Capitanescu, Florin; Wehenkel, Louis

    2008-01-01

    This paper deals with techniques to solve the corrective security-constrained optimal power flow (CSCOPF) problem. To this end, we propose a new iterative approach that comprises four modules: a CSCOPF which considers only a subset of potentially binding contingencies among the postulated ones, a (steady-state) security analysis (SSSA), a contingency filtering (CF) technique, and an OPF variant to check post-contingency state feasibility when taking into account po...

  2. A constrained approach to multiscale stochastic simulation of chemically reacting systems

    KAUST Repository

    Cotter, Simon L.

    2011-01-01

    Stochastic simulation of coupled chemical reactions is often computationally intensive, especially if a chemical system contains reactions occurring on different time scales. In this paper, we introduce a multiscale methodology suitable to address this problem, assuming that the evolution of the slow species in the system is well approximated by a Langevin process. It is based on the conditional stochastic simulation algorithm (CSSA) which samples from the conditional distribution of the suitably defined fast variables, given values for the slow variables. In the constrained multiscale algorithm (CMA) a single realization of the CSSA is then used for each value of the slow variable to approximate the effective drift and diffusion terms, in a similar manner to the constrained mean-force computations in other applications such as molecular dynamics. We then show how using the ensuing Fokker-Planck equation approximation, we can in turn approximate average switching times in stochastic chemical systems. © 2011 American Institute of Physics.

  3. Dicty_cDB: SSA365 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA365 (Link to dictyBase) - G20758 DDB0185325 Contig-U04375-1 SSA...365E (Link to Original site) - - - - - - SSA365E 349 Show SSA365 Library SS (Link to library) Clone ID SSA...riginal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA3-C/SSA365Q.Seq.d/ ...Representative seq. ID SSA365E (Link to Original site) Representative DNA sequence >SSA365 (SSA365Q) /CSM/SS/SSA3-C/SSA...core E Sequences producing significant alignments: (bits) Value SSA365 (SSA365Q) /CSM/SS/SSA3-C/SSA365Q.Seq.

  4. Dicty_cDB: SSA672 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA672 (Link to dictyBase) - - - Contig-U12249-1 SSA672E (Link... to Original site) - - - - - - SSA672E 573 Show SSA672 Library SS (Link to library) Clone ID SSA672 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA6-C/SSA672Q.Seq.d/ Representative seq. ID SSA67...2E (Link to Original site) Representative DNA sequence >SSA672 (SSA672Q) /CSM/SS/SSA6-C/SSA672Q.Seq.d/ ATTAT....Seq.d/ 1104 0.0 SSF809 (SSF809Q) /CSM/SS/SSF8-A/SSF809Q.Seq.d/ 1104 0.0 SSF627 (SSF627Q) /CSM/SS/SSF6-B/SSF627Q.Seq.d/ 1104 0.0 SSA

  5. Dicty_cDB: SSA166 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA166 (Link to dictyBase) - - - Contig-U14969-1 SSA166F (Link to Original site) SSA...166F 455 - - - - - - Show SSA166 Library SS (Link to library) Clone ID SSA166 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA1-C/SSA166Q.Seq.d/ Representative seq. ID SSA16...6F (Link to Original site) Representative DNA sequence >SSA166 (SSA166Q) /CSM/SS/SSA1-C/SSA166Q.Seq.d/ GCAAG... (bits) Value VSK402 (VSK402Q) /CSM/VS/VSK4-A/VSK402Q.Seq.d/ 137 2e-31 SSL708 (SSL708Q) /CSM/SS/SSL7-A/SSL708Q.Seq.d/ 137 2e-31 SSA

  6. Dicty_cDB: SSA269 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA269 (Link to dictyBase) - - - Contig-U16244-1 SSA269Z (Link... to Original site) - - SSA269Z 504 - - - - Show SSA269 Library SS (Link to library) Clone ID SSA269 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA2-C/SSA269Q.Seq.d/ Representative seq. ID SSA26...9Z (Link to Original site) Representative DNA sequence >SSA269 (SSA269Q) /CSM/SS/SSA2-C/SSA269Q.Seq.d/ XXXXX...letal 4.0 %: vacuolar 4.0 %: plasma membrane >> prediction for SSA269 is cyt 5' end seq. ID - 5' end seq. -

  7. Dicty_cDB: SSA765 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA765 (Link to dictyBase) - - - Contig-U16394-1 SSA765Z (Link... to Original site) - - SSA765Z 154 - - - - Show SSA765 Library SS (Link to library) Clone ID SSA765 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA7-C/SSA765Q.Seq.d/ Representative seq. ID SSA76...5Z (Link to Original site) Representative DNA sequence >SSA765 (SSA765Q) /CSM/SS/SSA7-C/SSA765Q.Seq.d/ XXXXX...htriyay*k*k*kkknnv*n*k Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSA765 (SSA

  8. Dicty_cDB: SSA854 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA854 (Link to dictyBase) ssa854 - - Contig-U16352-1 SSA854F ...(Link to Original site) SSA854F 249 - - - - - - Show SSA854 Library SS (Link to library) Clone ID SSA854 (Li...nk to dictyBase) Atlas ID ssa854 NBRP ID - dictyBase ID - Link to Contig Contig-U16352-1 Original site URL h...ttp://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA8-C/SSA854Q.Seq.d/ Representative seq. ID SSA...854F (Link to Original site) Representative DNA sequence >SSA854 (SSA854Q) /CSM/SS/SSA8-C/SSA854Q.Se

  9. Dicty_cDB: SSA572 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA572 (Link to dictyBase) - - - Contig-U11935-1 SSA572F (Link to Original site) SSA...572F 580 - - - - - - Show SSA572 Library SS (Link to library) Clone ID SSA572 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA5-C/SSA572Q.Seq.d/ Representative seq. ID SSA57...2F (Link to Original site) Representative DNA sequence >SSA572 (SSA572Q) /CSM/SS/SSA5-C/SSA572Q.Seq.d/ ATGAA...ASSVIDTFLAPGSPLLNVV IHGHYLETAFNS--- Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSA572 (SSA

  10. Dicty_cDB: SSA568 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA568 (Link to dictyBase) - - - Contig-U04420-1 SSA568E (Link to Original site) SSA...568F 423 SSA568Z 348 SSA568P 771 SSA568E 423 Show SSA568 Library SS (Link to library) Clone ID SSA...nal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA5-C/SSA568Q.Seq.d/ Representative seq. ID SSA...568E (Link to Original site) Representative DNA sequence >SSA568 (SSA568Q) /CSM/SS/SSA5-C/SSA...ces producing significant alignments: (bits) Value SSA568 (SSA568Q) /CSM/SS/SSA5-C/SSA568Q.Seq.d/ 529 e-149

  11. Dicty_cDB: SSA154 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA154 (Link to dictyBase) - - - Contig-U16544-1 SSA154E (Link... to Original site) - - - - - - SSA154E 255 Show SSA154 Library SS (Link to library) Clone ID SSA154 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA1-C/SSA154Q.Seq.d/ Representative seq. ID SSA15...4E (Link to Original site) Representative DNA sequence >SSA154 (SSA154Q) /CSM/SS/SSA1-C/SSA154Q.Seq.d/ ATTTT...( C46264 ) thioredoxin 3 - slime mold (Dictyostelium discoid... 55 6e-07 BT057388_1( BT057388 |pid:none) Salmo salar clone ssa

  12. Dicty_cDB: SSA261 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA261 (Link to dictyBase) - G02045 DDB0235194 Contig-U04344-1 SSA...261F (Link to Original site) SSA261F 301 - - - - - - Show SSA261 Library SS (Link to library) Clone ID SSA...riginal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA2-C/SSA261Q.Seq.d/ ...Representative seq. ID SSA261F (Link to Original site) Representative DNA sequence >SSA261 (SSA261Q) /CSM/SS/SSA2-C/SSA...I4-B/SSI429Q.Seq.d/ 436 e-122 SSA261 (SSA261Q) /CSM/SS/SSA2-C/SSA261Q.Seq.d/ 436 e-122 VSH479 (VSH479Q) /CSM

  13. Interní audit a řízení rizik v organizační složce státu

    OpenAIRE

    Hamšík, Petr

    2014-01-01

    Bachelor thesis „Internal auditing and Risk Management in a State Organisational Unit“ deals with the assessment of the role and status of internal audit in the organizational folder State. Literature search contains basic information related to the issue. In the next section is rated the implementation of internal audits and risk management in an organizational folder State. The organizational component of the State in this case is the Czech administration of social security (CSSA).

  14. Decentralized Cooperation Strategies in Two-Dimensional Traffic of Cellular Automata

    International Nuclear Information System (INIS)

    We study the two-dimensional traffic of cellular automata using computer simulation. We propose two type of decentralized cooperation strategies, which are called stepping aside (CS-SA) and choosing alternative routes (CS-CAR) respectively. We introduce them into an existing two-dimensional cellular automata (CA) model. CS-SA is designed to prohibit a kind of ping-pong jump when two objects standing together try to move in opposite directions. CS-CAR is designed to change the solution of conflict in parallel update. CS-CAR encourages the objects involved in parallel conflicts choose their alternative routes instead of waiting. We also combine the two cooperation strategies (CS-SA-CAR) to test their combined effects. It is found that the system keeps on a partial jam phase with nonzero velocity and flow until the density reaches one. The ratios of the ping-pong jump and the waiting objects involved in conflict are decreased obviously, especially at the free phase. And the average flow is improved by the three cooperation strategies. Although the average travel time is lengthened a bit by CS-CAR, it is shorten by CS-SA and CS-SA-CAR. In addition, we discuss the advantage and applicability of decentralized cooperation modeling.

  15. Decentralized Cooperation Strategies in Two-Dimensional Traffic of Cellular Automata

    Institute of Scientific and Technical Information of China (English)

    方峻; 覃征; 陈喜群; 冷彪; 徐朝晖; 江子能

    2012-01-01

    We study the two-dimensional traffic of cellular automata using computer simulation. We propose two type of decentralized cooperation strategies, which are called stepping aside (CS-SA) and choosing alternative routes (CS-CAR) respectively. We introduce them into an existing two-dimensional cellular automata (CA) model. CS-SA is designed to prohibit a kind of ping-pong jump when two objects standing together try to move in opposite directions. CS-CAR is designed to change the solution of conflict in parallel update. CS-CAR encourages the objects involved in parallel conflicts choose their alternative routes instead of waiting. We also combine the two cooperation strategies (CS-SA-CAR) to test their combined effects. It is found that the system keeps on a partial jam phase with nonzero velocity and flow until the density reaches one. The ratios of the ping-pong jump and the waiting objects involved in conflict are decreased obviously, especially at the free phase. And the average flow is improved by the three cooperation strategies. Although the average travel time is lengthened a bit by CS-CAR, it is shorten by CS-SA and CS-SA-CAR. In addition, we discuss the advantage and applicability of decentralized cooperation modeling.

  16. Reduced mucosal side-effects of acetylsalicylic acid after conjugation with tris-hydroxymethyl-aminomethane. Synthesis and biological evaluation of a new anti-inflammatory compound.

    Science.gov (United States)

    Varga, Gabriella; Lajkó, Norbert; Ugocsai, Melinda; Érces, Dániel; Horváth, Gyöngyi; Tóth, Gábor; Boros, Mihály; Ghyczy, Miklós

    2016-06-15

    Acetylsalicylic acid (ASA) causes adverse haemorrhagic reactions in the upper gastrointestinal (GI) tract, and previous results have suggested that combination therapy with 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) could provide protection in this scenario. Based on this hypothesis, our aim was to develop a new compound from ASA and Tris precursors and to characterize the biological effects of ASA-Tris and the derivatives ASA-bis- and mono-hydroxymethyl-aminomethane (ASA-Bis, ASA-Mono, respectively) using in vivo and in vitro test systems. ASA or ASA conjugates (0.55mmol/kg, each) were administered intragastrically to Sprague-Dawley rats. Changes in the mucosal structure and in the serosal microcirculation were detected by in vivo imaging techniques, the plasma TNF-alpha, tissue xanthine oxidoreductase and myeloperoxidase activities, and liver cytochrome c changes were also determined. In two separate series, platelet aggregation and carrageenan arthritis-induced inflammatory pain were measured in control, ASA and ASA-Tris-treated groups. Severe mucosal injury and a significant decrease in serosal red blood cell velocity developed in the ASA-treated group and an ~2-fold elevation in proinflammatory mediator levels evolved. ASA-Tris did not cause bleeding, microcirculatory dysfunction, mucosal injury or an elevation in proinflammatory markers. The ASA-Mono and ASA-Bis conjugates did not cause macroscopic bleeding, but the inflammatory activation was apparent. ASA-Tris did not influence the cyclooxygenase-induced platelet aggregation significantly, but the inflammatory pain was reduced as effectively as in the case of equimolar ASA doses. ASA-Tris conjugation is an effective approach through which the GI side-effects of ASA are controlled by decreasing the cytokine-mediated progression of pro-inflammatory events.

  17. Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration

    OpenAIRE

    Kousaku Kawashima; Shunji Ishihara; Takafumi Yuki; Koji Onishi; Yoshinori Kushiyama; Hirofumi Fujishiro; Youichi Miyaoka; Mika Yuki; Yoshinori Komazawa; Takashi Tanimura; Hiroki Sonoyama; Yasumasa Tada; Ryusaku Kusunoki; Akihiko Oka; Nobuhiko Fukuba

    2014-01-01

    Purpose. Few reports have compared the clinical efficacy of a pH-dependent release formulation of mesalazine (pH-5-ASA) with a time-dependent release formulation (time-5-ASA). We examined whether pH-5-ASA is effective for active ulcerative colitis (UC) in patients resistant to time-5-ASA. Methods. We retrospectively and prospectively analyzed the efficacy of pH-5-ASA in mildly to moderately active UC patients in whom time-5-ASA did not successfully induce or maintain remission. The clinical e...

  18. Long-distance transport of L-ascorbic acid in potato

    Directory of Open Access Journals (Sweden)

    Alberino Salvatore

    2004-09-01

    Full Text Available Abstract Background Following on from recent advances in plant AsA biosynthesis there is increasing interest in elucidating the factors contributing to the L-ascorbic acid (AsA content of edible crops. One main objective is to establish whether in sink organs such as fruits and tubers, AsA is synthesised in situ from imported photoassimilates or synthesised in source tissues and translocated via the phloem. In the current work we test the hypothesis that long-distance transport is involved in AsA accumulation within the potato tuber, the most significant source of AsA in the European diet. Results Using the EDTA exudation technique we confirm the presence of AsA in the phloem of potato plants and demonstrate a correlation between changes in the AsA content of source leaves and that of phloem exudates. Comparison of carboxyflourescein and AgNO3 staining is suggestive of symplastic unloading of AsA in developing tubers. This hypothesis was further supported by the changes in AsA distribution during tuber development which closely resembled those of imported photoassimilates. Manipulation of leaf AsA content by supply of precursors to source leaves resulted in increased AsA content of developing tubers. Conclusion Our data provide strong support to the hypothesis that long-distance transport of AsA occurs in potato. We also show that phloem AsA content and AsA accumulation in sink organs can be directly increased via manipulation of AsA content in the foliage. We are now attempting to establish the quantitative contribution of imported AsA to overall AsA accumulation in developing potato tubers via transgenic approaches.

  19. Alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy

    DEFF Research Database (Denmark)

    Jensen, Morten K; Prinz, Christian; Horstkotte, Dieter;

    2013-01-01

    The infarction induced by alcohol septal ablation (ASA) may predispose to arrhythmia and sudden cardiac death (SCD).......The infarction induced by alcohol septal ablation (ASA) may predispose to arrhythmia and sudden cardiac death (SCD)....

  20. NEW METABOLITES OF THE DRUG 5-AMINOSALICYLIC ACID .2. N-FORMYL-5-AMINOSALICYLIC ACID

    DEFF Research Database (Denmark)

    Tjornelund, J.; Hansen, S. H.; Cornett, Claus

    1991-01-01

    -formamidosalicylic acid) using H-1- and C-13-n.m.r. spectrometry and mass spectroscopy and the structure was confirmed by chemical synthesis. 3. N-Formyl-5-ASA is stable in human plasma and in potassium phosphate buffers between pH 3.0 and 9.0. It is hydrolysed below pH 3.0. 4. N-Formyl-5-ASA was readily formed...... in rat liver homogenate when 5-ASA and N-formyl-L-kynurenine were added. Thus N-formyl-5-ASA might be formed by the actions of formamidase in vivo. 5. N-Formyl-5-ASA has been found in human plasma from healthy volunteers dosed i.v. with 5-ASA (250 mg). N-beta-D-glucopyranosyl-5-ASA, N-acetyl-5-ASA and N...

  1. Burden of upper gastrointestinal symptoms in patients receiving low-dose acetylsalicylic acid for cardiovascular risk management

    DEFF Research Database (Denmark)

    Bytzer, Peter; Pratt, Stephen; Elkin, Eric;

    2013-01-01

    Continuous low-dose acetylsalicylic acid (aspirin; ASA) is a mainstay of cardiovascular (CV) risk management. It is well established, however, that troublesome upper gastrointestinal (GI) symptoms are commonly experienced among low-dose ASA users.......Continuous low-dose acetylsalicylic acid (aspirin; ASA) is a mainstay of cardiovascular (CV) risk management. It is well established, however, that troublesome upper gastrointestinal (GI) symptoms are commonly experienced among low-dose ASA users....

  2. Fragment o dimenzijah emocije, "mathesisa" in časa v čisto glasbenem: A fragment on the emotion, "mathesis" and the time dimension of the purely musical: marginalia with Prelude to the afternoon of a faun by Claude Debussy: pripombe ob Preludiju k faunovemu popoldnevu Claudea Debussyja:

    OpenAIRE

    Popović Mlađenović, Tijana

    2007-01-01

    In the dialogue What Is Music? between Carl Dahlhaus and Hans Heinrich Eggebrecht, music is defined as a "mathematized emotion" or an "emotionalized 'mathesis'". As emphasized by Marija Bergamo, this is the way of underlining its equal and unavoidable constitution, based on emotion and rational organization in the time dimension. So, Marija Bergamo is continuously searching for those music determinants in a musical work as an "autonomous aesthetic fact", whose base and real essence lie "withi...

  3. AHA/ASA关于卒中和短暂性脑缺血发作患者卒中预防推荐的更新%Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

    Institute of Scientific and Technical Information of China (English)

    Robert J. Adams; S. Claiborne Johnston; Irene Katzan; Margaret Kelly-Hayes; Edgar J. Kenton; Michael Marks; Ralph L. Sacco; Lee H. Schwamm; 赵洪芹; 李海峰; Greg Albers; Mark J. Alberts; Oscar Benavente; Karen Furie; Larry B. Goldstein; Philip Gorelick; Jonathan Halperin; Robert Harbaugh

    2008-01-01

    在卒中和短暂性脑缺血发作(transient ischemic attack,TIA)患者卒中预防推荐发表以后,美国心脏协会和美国卒中协会(American Heart Association/American Stroke Association,AHA/ASA)著述委员会对最近的一些试验结果进行了回顾。本文的目的是对这些新资料做简要回顾、更新某些推荐意见并说明进行这些修改的理由。在2个领域已发表了一些新的重要临床试验结果:(1)在非心源性栓塞所致缺血性卒中或TIA患者卒中二级预防中具体抗血小板药的应用;(2)他汀类药物在预防卒中复发中的应用。

  4. 5-Aminosalicylic acid dependency in Crohn's disease: A Danish Crohn Colitis Database study

    DEFF Research Database (Denmark)

    Duricova, D.; Pedersen, N.; Elkjaer, M.;

    2010-01-01

    Background and aims The role of 5 aminosalicylic acid (5 ASA) in Crohns disease is unclear The outcome of the first course of 5 ASA monotherapy with emphasis on 5 ASA dependency was retrospectively assessed in consecutive cohort of 537 Crohn s disease patients diagnosed 1953-2007 Methods Following...

  5. Patient characteristics among users of analgesic over-the-counter aspirin in a Danish pharmacy setting

    DEFF Research Database (Denmark)

    Pottegård, Anton; Kviesgaard, Ann-Katrine; Hesse, Ulrik;

    2014-01-01

    BACKGROUND: Use of over-the-counter (OTC) high-dose acetylsalicylic acid (ASA) is a risk factor for experiencing gastric bleeding. However, more detailed knowledge on the characteristics of users of OTC ASA is needed. OBJECTIVE: To characterise users of OTC high-dose ASA in a Danish pharmacy...

  6. Illuminating tomato fruit enhances fruit Vitamin C content

    NARCIS (Netherlands)

    Ntagkas, N.; Min, Q.; Woltering, E.J.; Labrie, C.; Nicole, C.C.S.; Marcelis, L.F.M.

    2016-01-01

    L-ascorbate (AsA; Vitamin C) is an anti-and pro-oxidant phytochemical essential for the proper functioning of the human body. Field grown tomato fruit (Solanum lycopersicum) contain substantial amounts of AsA. When grown in the greenhouse, tomato fruit typically have low levels of AsA. Light is t

  7. ACETYLSALICYLIC ACID IN THE PREVENTION OF ATHEROTHROMBOTIC EVENTS

    Directory of Open Access Journals (Sweden)

    A. V. Govorin

    2015-12-01

    Full Text Available The results of large-scale clinical trials have convincingly demonstrated the effectiveness of acetylsalicylic acid (ASA in primary and secondary prevention of atherothrombotic events. Studies on the safety of different ASA formulations have been continuing. Magnesium hydroxide included in combined medicine, Сardiomagnil, prevents ASA adverse effects on the gastric mucosa and reduces in severity of dyspeptic symptoms.

  8. ACETYLSALICYLIC ACID IN THE PREVENTION OF ATHEROTHROMBOTIC EVENTS

    Directory of Open Access Journals (Sweden)

    A. V. Govorin

    2012-01-01

    Full Text Available The results of large-scale clinical trials have convincingly demonstrated the effectiveness of acetylsalicylic acid (ASA in primary and secondary prevention of atherothrombotic events. Studies on the safety of different ASA formulations have been continuing. Magnesium hydroxide included in combined medicine, Сardiomagnil, prevents ASA adverse effects on the gastric mucosa and reduces in severity of dyspeptic symptoms.

  9. A novel dissolution method relevant to intestinal release behaviour and its application in the evaluation of modified release mesalazine products

    NARCIS (Netherlands)

    Schellekens, R.C.A.; Stuurman, F.E.; van der Weert, F.H.J.; Kosterink, J.G.W.; Frijlink, H.W.

    2007-01-01

    Mesalazine (5-ASA) is a compound being used in the therapy of inflammatory bowel disease (IBD). Considering the fact that 5-ASA is locally active and that the location of inflammation in IBD may vary, it is recognized that the release profile of 5-ASA drugs is the dominant factor for adequate local

  10. Platelet content of nitric oxide synthase 3 phosphorylated at Serine 1177 is associated with the functional response of platelets to aspirin.

    Directory of Open Access Journals (Sweden)

    Javier Modrego

    Full Text Available OBJECTIVE: To analyse if platelet responsiveness to aspirin (ASA may be associated with a different ability of platelets to generate nitric oxide (NO. PATIENTS/METHODS: Platelets were obtained from 50 patients with stable coronary ischemia and were divided into ASA-sensitive (n = 26 and ASA-resistant (n = 24 using a platelet functionality test (PFA-100. RESULTS: ASA-sensitive platelets tended to release more NO (determined as nitrite + nitrate than ASA-resistant platelets but it did not reach statistical significance. Protein expression of nitric oxide synthase 3 (NOS3 was higher in ASA-sensitive than in ASA-resistant platelets but there were no differences in the platelet expression of nitric oxide synthase 2 (NOS2 isoform. The highest NOS3 expression in ASA-sensitive platelets was independent of the presence of T-to-C mutation at nucleotide position -786 (T(-786 → C in the NOS3-coding gene. However, platelet content of phosphorylated NOS3 at Serine (Ser(1177, an active form of NOS3, was higher in ASA-sensitive than in ASA-resistant platelets. The level of platelet NOS3 Ser(1177 phosphorylation was positively associated with the closure time in the PFA-100 test. In vitro, collagen failed to stimulate the aggregation of ASA-sensitive platelets, determined by lumiaggregometry, and it was associated with a significant increase (p = 0.018 of NOS3 phosphorylation at Ser(1177. On the contrary, collagen stimulated the aggregation of ASA-resistant platelets but did not significantly modify the platelet content of phosphorylated NOS3 Ser(1177. During collagen stimulation the release of NO from ASA-sensitive platelets was significantly enhanced but it was not modified in ASA-resistant platelets. CONCLUSIONS: Functional platelet responsiveness to ASA was associated with the platelet content of phosphorylated NOS3 at Ser(1177.

  11. Research on the Mode of ASP-based Services Alliance for SME

    Institute of Scientific and Technical Information of China (English)

    MEI Yi; LIU Dan; YANG Wenjie

    2006-01-01

    More and more small and medium enterprises(SMEs) carry professional information systems into effect by Application Service Provider(ASP). However, lots of ASP has just single function so that they can't meet needs for collaborative commerce among SMEs. Therefore, the ASP-based Services Alliance (ASA) is proposed to raise level of information application for SMEs. The formation process of ASA is introduced, some key methods supporting ASA formation are presented and the practice of ASA in Guizhou province which was developed with the key methods discussed. SMEs can get high quality, low cost online services and the ability of capturing market with allied member collaboratively through ASA.

  12. La seguridad alimentaria en Venezuela. 2. Una evaluación de políticas públicas en relación a la autosuficiencia o autonomía alimentaria. Período 1999-2012

    Directory of Open Access Journals (Sweden)

    Daniel Castro Aniyar

    2013-06-01

    Full Text Available Luego de evaluar en la primera parte otros objetivos de la seguridad alimentaria venezolana, esta segunda parte enfocó la evaluación de la autosuficiencia o autonomía alimentaria según criterios de la FAO. Tal evaluación se realizó mediante la comparación, por un lado, de 22 emprendimientos productivos y de provisión alimentarios y no alimentarios convocados por el Sistema Socialista de Soberanía Alimentaria (SSSA y, por el otro, de indicadores macroeconómicos y socio-productivos extraídos de diferentes fuentes oficiales de manera directa e indirecta. Se concluye que, a diferencia de los anteriores objetivos evaluados, el SSSA logró levantar someramente la producción nacional pero el resultado fue contrario al deseado: los emprendimientos productivos iniciados en la sociedad civil han descendido, al menos, desde el 2007 y, además, muchos de los que comenzaron han fenecido tempranamente. El derrumbe de los nuevos emprendimientos es particularmente más pronunciado que el de otros países latinoamericanos como Perú, Guatemala, Colombia o Brasil. En este sentido, la dependencia del sector externo ha sido mucho mayor en el 2012 que antes del SSSA y sus indicadores se encuentran más de 40 puntos por debajo de los niveles críticos establecidos por la FAO, situación que se agravó al menos desde el 2007.

  13. [Pharmacokinetics after oral and intravenous administration of d,l-monolysine acetylsalicylate and an oral dose of acetylsalicylic acid in healthy volunteers].

    Science.gov (United States)

    Raschka, C; Koch, H J

    2001-01-01

    We studied the ASA pharmacokinetics of single doses of 500 mg and 1000 mg of D,L-lysine-monoacetylsalicylate (Lys-ASA) administered both orally (Delgesic) and 500 mg parenterally (Aspisol) as well as 500 mg acetylsalicylate (ASA, Aspirin) in 13 healthy volunteers. Blood samples were taken before and at defined times up to 48 h after application of Lys-ASA and ASA. Analysis for ASA and its metabolite salicylic acid were performed by HPLC. All concentration versus time data were presented descriptively. As far as ASA was concerned, differences were assessed by means of ANOVA according to Friedman including post hoc Wilcoxon tests for each time point. Pharmacokinetic parameters were calculated based on a one-compartment model. The concentration vs. time curves after oral intake of 500 mg of ASA and Lys-ASA differed significantly (p salicylic acid concentration after injection of Lys-ASS. We conclude that concerning time dimension oral administration of Lys-ASA is almost equivalent to i.v. Lys-ASA and may be an alternative for i.v. administration in cases of acute heart attacks. PMID:11878089

  14. 青少年主观社会经济地位量表的初步编制%Development of Subjective Socioeconomic Status Scale for Chinese Adolescents

    Institute of Scientific and Technical Information of China (English)

    胡牡丽; 王孟成; 蔡琳; 朱熊兆; 姚树桥

    2012-01-01

    Objective: To develop a Subjective Socioeconomic Status Scale for Chinese Adolescents. Methods: A total of 6687 middle school students, from grade 7 to grade 12, finished SSS-A and other scales from four cities of China, 495 of them finished the SSS-A the second time after 3 weeks. Results: The intraclass correlation coefficient of SSS-A was 0.78, 0.76 for the family place and 0.71 for the school place; criterion validity analyses showed SSS-A had significant negative correlation with CES-D and MASC(r=-0.14—0.38, P<0.01), and positive correlation with the RSES and objective SES(r=0.12~0.44,P<0.01). Conclusion: The Subjective Socioeconomic Status Scale for Chinese Adolescents in the present study attains acceptable psychometric properties.%目的:编制适合于中国青少年的主观社会经济地位量表.方法:长沙、成都、苏州和银川四市6687名初一至高三学生完成青少年主观社会经济地位(SSS-A)等量表,其中495人间隔3周进行了重测.结果:SSS-A的重测信度为0.78,家庭地位和学校地位两条目的重测信度分别是0.76、0.71;SSS-A总分和两条目与流调中心用抑郁量表(CES-D)、儿童多维焦虑自评量表(MASC-C)得分呈负相关(r=-0.14~-0.38,P<0.01),与Rosemberg自尊量表(RSES)总分和客观SES指标显著正相关(r=0.12~0.44,P<0.01).结论:本研究编制的SSS-A具有良好的信效度,适用于我国青少年的主观社会经济地位评估.

  15. L-Ascorbic acid metabolism during fruit development in an ascorbate-rich fruit crop chestnut rose (Rosa roxburghii Tratt).

    Science.gov (United States)

    Huang, Ming; Xu, Qiang; Deng, Xiu-Xin

    2014-09-01

    Chestnut rose (Rosa roxburghii Tratt) is a fruit crop that contains unusually high levels of l-ascorbic acid (AsA; ∼1300 mg 100g(-1) FW). To explore the mechanisms underlying AsA metabolism, we investigated the distribution and abundance of AsA during fruit development. We also analyzed gene expression patterns, enzyme activities, and content of metabolites related to AsA biosynthesis and recycling. AsA first accumulated during late fruit development and continued to accumulate during ripening, with the highest accumulation rate near fruit maturity. The redox state of AsA in fruit was also enhanced during late fruit development, while leaf and other tissues had much lower levels of AsA and the redox state of AsA was lower. In mature fruit, AsA was mainly distributed in the cytoplasm of the mesocarp. Correlation analysis suggested that the gene expression patterns, enzyme activities, and related metabolite concentrations involved in the l-galactose pathway showed relatively high correlations with the accumulation rate of AsA. The gene expression pattern and activity of dehydroascorbate reductase (DHAR, EC 1.8.5.1) correlated strongly with AsA concentration, possibly indicating the crucial role of DHAR in the accumulation of high levels of AsA in chestnut rose fruit. Over expression of DHAR in Arabidopsis significantly increased the reduced AsA content and redox state. This was more effective than over expression of the l-galactose pathway gene GDP-d-mannose-3,5-epimerase (EC 5.1.3.18). These findings will enhance understanding of the molecular mechanisms regulating accumulation of AsA in chestnut rose. PMID:25019249

  16. A new method for the characterization of strain-specific conformational stability of protease-sensitive and protease-resistant PrPSc.

    Directory of Open Access Journals (Sweden)

    Laura Pirisinu

    Full Text Available Although proteinacious in nature, prions exist as strains with specific self-perpetuating biological properties. Prion strains are thought to be associated with different conformers of PrP(Sc, a disease-associated isoform of the host-encoded cellular protein (PrP(C. Molecular strain typing approaches have been developed which rely on the characterization of protease-resistant PrP(Sc. However, PrP(Sc is composed not only of protease-resistant but also of protease-sensitive isoforms. The aim of this work was to develop a protocol for the molecular characterization of both, protease-resistant and protease-sensitive PrP(Sc aggregates. We first set up experimental conditions which allowed the most advantageous separation of PrP(C and PrP(Sc by means of differential centrifugation. The conformational solubility and stability assay (CSSA was then developed by measuring PrP(Sc solubility as a function of increased exposure to GdnHCl. Brain homogenates from voles infected with human and sheep prion isolates were analysed by CSSA and showed strain-specific conformational stabilities, with mean [GdnHCl](1/2 values ranging from 1.6 M for MM2 sCJD to 2.1 for scrapie and to 2.8 M for MM1/MV1 sCJD and E200K gCJD. Interestingly, the rank order of [GdnHCl](1/2 values observed in the human and sheep isolates used as inocula closely matched those found following transmission in voles, being MM1 sCJD the most resistant (3.3 M, followed by sheep scrapie (2.2 M and by MM2 sCJD (1.6 M. In order to test the ability of CSSA to characterise protease-sensitive PrP(Sc, we analysed sheep isolates of Nor98 and compared them to classical scrapie isolates. In Nor98, insoluble PrP(Sc aggregates were mainly protease-sensitive and showed a conformational stability much lower than in classical scrapie. Our results show that CSSA is able to reveal strain-specified PrP(Sc conformational stabilities of protease-resistant and protease-sensitive PrP(Sc and that it is a valuable tool

  17. Effects of L-glutamine on acetylsalycylic acid induced gastric lesions and acid back diffusion in dogs.

    Science.gov (United States)

    Hung, C R; Takeuchi, K; Okabe, S; Murata, T; Takagi, K

    1976-12-01

    Effects of L-glutamine on acetylsalicylic acid (ASA)-induced gastric mucosal lesions were studied in mongrel dogs. It was confirmed that when oral ASA at 1.0 or 2.0 g per dog is given in two divided doses, there is severe and consistent dose-dependent mucosal damage in the glandular portion of the stomach in fasted dogs. However, when L-glutamine 2.0 or 4.0 g per dog in two divided doses is given concomitantly with ASA 2.0 g per dog orally, the gastric irritation is significantly inhibited. Instillation of 20 mM of ASA in 100 mM HCl solution into the Heidenhain pouch of Beagle dogs produced a significant loss of H+ from the pouch and a gain of Na+ in the lumen compared with ASA-free controls. When L-glutamine (100 mM) was given concomitantly with ASA (20 mM) into the pouch, changes of electrolyte fluxes in response to ASA alone were significantly suppressed. However, 50 mM of L-glutamine had no appreciable effect on acid back diffusion caused by ASA 20 mM. The amino acid itself had little effect on the ionic movement in the pouch. Gross bleeding from the pouch treated with ASA was never observed with the concomitant dosing of ASA and L-glutamine 50 or 100 mM. PMID:15154

  18. Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers.

    Science.gov (United States)

    Benedek, I H; Joshi, A S; Pieniaszek, H J; King, S Y; Kornhauser, D M

    1995-12-01

    Data describing the pharmacokinetics and pharmacodynamics of low dose aspirin (acetylsalicylic acid; ASA) are limited. This single-center study was designed to determine the rate and extent of oral absorption of 80-mg ASA tablets in healthy, young male subjects and to assess the intra- and inter-subject variability of ASA pharmacokinetics and platelet aggregation effects. Ten subjects each received a single, open-label, oral 80-mg ASA dose on three separate days. Each dose was separated by a 2-week washout interval. Blood samples for pharmacokinetic determinations of ASA and its metabolite, salicylic acid (SA) and platelet aggregation studies were obtained at scheduled timepoints before and up to 24 hours after each dose. Peak plasma ASA levels of 1 microgram/mL were achieved within 30 minutes. Peak plasma SA levels of approximately 4 micrograms/mL were attained in 1 hour. The terminal half-lives (t1/2) of ASA and SA were 0.4 and 2.1 hours, respectively. Both ASA and SA pharmacokinetics and the platelet aggregation response to ASA exhibited considerable intra- and inter-subject variability. Inhibition of platelet aggregation was found to relate with ASA area under the plasma concentration versus time curve (AUC). PMID:8750369

  19. Acetylsalicylic acid protects erectile function in diabetic rats.

    Science.gov (United States)

    Hafez, G; Gonulalan, U; Kosan, M; Arioglu, E; Ozturk, B; Cetinkaya, M; Gur, S

    2014-01-01

    We aimed to evaluate the effect of acetylsalicylic acid (ASA) treatment on diabetes-induced erectile dysfunction. Adult male Sprague-Dawley rats were divided into four groups as follows: (i) control (C), (ii) diabetic (D), (iii) ASA-treated control (C+ASA) and (iv) ASA-treated diabetic (D+ASA) groups. In groups 2 and 4, diabetes was induced by injection of 35 mg kg(-1) streptozotocin. ASA (100 mg kg(-1) day(-1) , orally) was administrated to rats in groups 3 and 4 for 8 weeks. Both intracavernosal pressure (ICP) and mean arterial blood pressure (MAP) were measured in in vivo studies. In organ bath, the relaxation responses to acetylcholine (ACh), electrical field stimulation (EFS) and sodium nitroprusside were tested in corpus cavernosum (CC) strips. The mRNA expression for neuronal nitric oxide synthase (nNOS) was calculated using reverse transcription polymerase chain reaction technique. In in vivo experiments, diabetic rats displayed reduced ICP/MAP values, which were normalised with ASA treatment. The relaxant response to high-dose ACh and EFS at low frequencies (1-8 Hz) in CC strips from the D+ASA group were significantly higher when compared to the D group. Treatment with ASA normalised the raised mRNA expressions of nNOS in diabetic penile tissues. ASA may be involved in mRNA of protein synthesis of NO released from nonadrenergic and noncholinergic cavernosal nerve in diabetes.

  20. Accessible surface area from NMR chemical shifts

    International Nuclear Information System (INIS)

    Accessible surface area (ASA) is the surface area of an atom, amino acid or biomolecule that is exposed to solvent. The calculation of a molecule’s ASA requires three-dimensional coordinate data and the use of a “rolling ball” algorithm to both define and calculate the ASA. For polymers such as proteins, the ASA for individual amino acids is closely related to the hydrophobicity of the amino acid as well as its local secondary and tertiary structure. For proteins, ASA is a structural descriptor that can often be as informative as secondary structure. Consequently there has been considerable effort over the past two decades to try to predict ASA from protein sequence data and to use ASA information (derived from chemical modification studies) as a structure constraint. Recently it has become evident that protein chemical shifts are also sensitive to ASA. Given the potential utility of ASA estimates as structural constraints for NMR we decided to explore this relationship further. Using machine learning techniques (specifically a boosted tree regression model) we developed an algorithm called “ShiftASA” that combines chemical-shift and sequence derived features to accurately estimate per-residue fractional ASA values of water-soluble proteins. This method showed a correlation coefficient between predicted and experimental values of 0.79 when evaluated on a set of 65 independent test proteins, which was an 8.2 % improvement over the next best performing (sequence-only) method. On a separate test set of 92 proteins, ShiftASA reported a mean correlation coefficient of 0.82, which was 12.3 % better than the next best performing method. ShiftASA is available as a web server ( http://shiftasa.wishartlab.com http://shiftasa.wishartlab.com ) for submitting input queries for fractional ASA calculation

  1. La seguridad alimentaria en Venezuela. 1. Una evaluación de los sub-objetivos suficiencia, acceso, disponibilidad y estabilidad. Período 1999-2012

    Directory of Open Access Journals (Sweden)

    Daniel Castro Aniyar

    2013-01-01

    Full Text Available Este trabajo evaluó los alcances en seguridad alimentaria del Sistema Socialista de Soberanía Alimentaria en Venezuela (SSSA desde el año 1999 hasta el 2012, a partir de los sub-objetivos suficiencia, acceso, disponibilidad y estabilidad. Para tal fin, se comparó información extraída de los discursos oficiales, de políticas públicas, de diarios de campo entre 22 emprendimientos del poder popular (sociedad civil convocada, a lo largo de ese período y de los indicadores socioeconómicos desde diferentes fuentes a nivel nacional y regional. Se concluye que, para estos sub-objetivos, mejoraron los indicadores de suficiencia, disponibilidad real, acceso de manera relativamente estable para ese período y pobreza asociada, en relación con los niveles anteriores al SSSA. De mantenerse estas condiciones, el país lograría la meta de reducir la pobreza a la mitad para el 2015 según los Objetivos de Desarrollo del Milenio de la ONU y asociados. Estos indicadores fueron desarrollados principalmente mediante estrategias de provisión, comercialización, distribución y regulación de precios. Sin embargo, tal mejoría no se acompaña de aumentos suficientes de producción y de tierras cultivadas.

  2. La seguridad alimentaria en Venezuela. 1. Una evaluación de los sub-objetivos suficiencia, acceso, disponibilidad y estabilidad. Período 1999-2012

    Directory of Open Access Journals (Sweden)

    Daniel Castro Aniyar

    2013-06-01

    Full Text Available Este trabajo evaluó los alcances en seguridad alimentaria del Sistema Socialista de Soberanía Alimentaria en Venezuela (SSSA desde el año 1999 hasta el 2012, a partir de los sub-objetivos suficiencia, acceso, disponibilidad y estabilidad. Para tal fin, se comparó información extraída de los discursos oficiales, de políticas públicas, de diarios de campo entre 22 emprendimientos del poder popular (sociedad civil convocada, a lo largo de ese período y de los indicadores socioeconómicos desde diferentes fuentes a nivel nacional y regional. Se concluye que, para estos sub-objetivos, mejoraron los indicadores de suficiencia, disponibilidad real, acceso de manera relativamente estable para ese período y pobreza asociada, en relación con los niveles anteriores al SSSA. De mantenerse estas condiciones, el país lograría la meta de reducir la pobreza a la mitad para el 2015 según los Objetivos de Desarrollo del Milenio de la ONU y asociados. Estos indicadores fueron desarrollados principalmente mediante estrategias de provisión, comercialización, distribución y regulación de precios. Sin embargo, tal mejoría no se acompaña de aumentos suficientes de producción y de tierras cultivadas.

  3. Regulation of fruit ascorbic acid concentrations during ripening in high and low vitamin C tomato cultivars

    Directory of Open Access Journals (Sweden)

    Mellidou Ifigeneia

    2012-12-01

    Full Text Available Abstract Background To gain insight into the regulation of fruit ascorbic acid (AsA pool in tomatoes, a combination of metabolite analyses, non-labelled and radiolabelled substrate feeding experiments, enzyme activity measurements and gene expression studies were carried out in fruits of the ‘low-’ and ‘high-AsA’ tomato cultivars ‘Ailsa Craig’ and ‘Santorini’ respectively. Results The two cultivars exhibited different profiles of total AsA (totAsA, AsA + dehydroascorbate and AsA accumulation during ripening, but both displayed a characteristic peak in concentrations at the breaker stage. Substrate feeding experiments demonstrated that the L-galactose pathway is the main AsA biosynthetic route in tomato fruits, but that substrates from alternative pathways can increase the AsA pool at specific developmental stages. In addition, we show that young fruits display a higher AsA biosynthetic capacity than mature ones, but this does not lead to higher AsA concentrations due to either enhanced rates of AsA breakdown (‘Ailsa Craig’ or decreased rates of AsA recycling (‘Santorini’, depending on the cultivar. In the later stages of ripening, differences in fruit totAsA-AsA concentrations of the two cultivars can be explained by differences in the rate of AsA recycling activities. Analysis of the expression of AsA metabolic genes showed that only the expression of one orthologue of GDP-L-galactose phosphorylase (SlGGP1, and of two monodehydroascorbate reductases (SlMDHAR1 and SlMDHAR3 correlated with the changes in fruit totAsA-AsA concentrations during fruit ripening in ‘Ailsa Craig’, and that only the expression of SlGGP1 was linked to the high AsA concentrations found in red ripe ‘Santorini’ fruits. Conclusions Results indicate that ‘Ailsa Craig’ and ‘Santorini’ use complementary mechanisms to maintain the fruit AsA pool. In the low-AsA cultivar (‘Ailsa Craig’, alternative routes of AsA biosynthesis may

  4. Aspirin Increases the Solubility of Cholesterol in Lipid Membranes

    Science.gov (United States)

    Alsop, Richard; Barrett, Matthew; Zheng, Sonbo; Dies, Hannah; Rheinstadter, Maikel

    2014-03-01

    Aspirin (ASA) is often prescribed for patients with high levels of cholesterol for the secondary prevention of myocardial events, a regimen known as the Low-Dose Aspirin Therapy. We have recently shown that Aspirin partitions in lipid bilayers. However, a direct interplay between ASA and cholesterol has not been investigated. Cholesterol is known to insert itself into the membrane in a dispersed state at moderate concentrations (under ~37.5%) and decrease fluidity of membranes. We prepared model lipid membranes containing varying amounts of both ASA and cholesterol molecules. The structure of the bilayers as a function of ASA and cholesterol concentration was determined using high-resolution X-ray diffraction. At cholesterol levels of more than 40mol%, immiscible cholesterol plaques formed. Adding ASA to the membranes was found to dissolve the cholesterol plaques, leading to a fluid lipid bilayer structure. We present first direct evidence for an interaction between ASA and cholesterol on the level of the cell membrane.

  5. Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma

    OpenAIRE

    Moon, Hyung-Geun; Kim, You-sun; Choi, Jun-Pyo; Choi, Dong-Sic; Yoon, Chang Min; Jeon, Seong Gyu; Gho, Yong Song; Kim, Yoon-Keun

    2009-01-01

    Theophylline is commonly used to treat severe asthma and chronic obstructive pulmonary disease (COPD) characterized by non-eosinophilic inflammation. Acetyl salicylic acid (ASA) is one of the most widely used medications worldwide, but up to 20% of patients with asthma experience aggravated respiratory symptoms after taking ASA. Here we evaluated the adverse effect of ASA on the therapeutic effect of theophylline in mice with non-eosinophilic asthma. A non-eosinophilic asthma mouse model was ...

  6. Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

    OpenAIRE

    Khare, Vineeta; Lyakhovich, Alex; Dammann, Kyle; Lang, Michaela; Borgmann, Melanie; Tichy, Boris; Pospisilova, Sarka; Luciani, Gloria; Campregher, Christoph; Evstatiev, Rayko; Pflueger, Maren; Hundsberger, Harald; Gasche, Christoph

    2013-01-01

    Mesalamine (5-ASA) is widely used for the treatment of ulcerative colitis, a remitting condition characterized by chronic inflammation of the colon. Knowledge about the molecular and cellular targets of 5-ASA is limited and a clear understanding of its activity in intestinal homeostasis and interference with neoplastic progression is lacking. We sought to identify molecular pathways interfered by 5-ASA, using CRC cell lines with different genetic background. Microarray was performed for gene ...

  7. Comparative Efficacy and Acceptability of Anti-TNF-Alpha Therapy in Ankylosing Spondylitis: A Mixed-Treatments Comparison

    Directory of Open Access Journals (Sweden)

    Yehua Wang

    2016-09-01

    Full Text Available Background: Tumor necrosis factor α (TNFα antagonists, namely, golimumab, adalimumab, infliximab, etanercept and certolizumab have been prescribed to alleviate and treat ankylosing spondylitis (AS. However, the lack of comparative evidence does not enable us to make constructive recommendations particularly for AS patient populations. Methods: Eligible controlled trials regarding the above 5 anti-TNFα therapies were searched electronically through PubMed, Embase and Cochrane until April 1, 2015. Odds ratios (ORs were estimated and compared for efficacy (ASAS20, ASAS40, ASAS5/6 responses and ASAS partial remission and acceptability (serious adverse effects (SAE among the anti-TNFα reagents. Results: Totally, 25 trials with 2989 participants were incorporated in this mixed treatment comparison. All the 5 TNFα blockers achieved better ASAS20, ASAS40, ASAS5/6 and ASAS-PR responses than the placebo. Furthermore, there was no significant distinction existed among inter-drug comparisons, except that unfavorable effects induced by certolizumab seemed to be less severe than those by etanercept (OR = 0.22, 95% CI: 0.05-0.93. Apart from that, etanercept was estimated to arrive at the most favorable ASAS20 response (90.6% and SAE (83.6%, while infliximab seemed to accomplish the best ASAS40 (83.6% and ASAS-PR responses (77.3%. In addition, adalimumab was estimated to rank the highest ASAS5/6 response (75.0%. Conclusions: Etanercept, infliximab and adalimumab might be prioritized among the commonly recognized 5 anti-TNFα therapies specific for AS patients, though existing evidence did not suffice to confirm significant superiority among the above 5 anti-TNFα reagent.

  8. Inhibition of Murine Systemic Leishmaniasis by Acetyl Salicylic Acid Via Nitric Oxide Immunomodulation

    OpenAIRE

    Assmar, M; Farahmand, M; M Jalalian; Nahrevanian, H; AR Esmaeili Rastaghi; Sayyah, M.

    2012-01-01

    Background: The purpose of this study was to evaluate antileishmanial effects of ASA via NO pathway in Leishmania major infected Balb/c mice. Moreover, toxicity and pathological consequences of ASA administration were investigated.Methods: Balb/c mice were infected with L. major and ASA was inoculated orally after lesion appearance for its ability to modulate NO and to modify Leishmania infection in host, in order to evaluate the effects of NO production on size and lesion macroscopy, delay o...

  9. A spectroscopic study of phenylbutazone and aspirin bound to serum albumin in rheumatoid diseases

    Science.gov (United States)

    Maciążek-Jurczyk, M.; Sułkowska, A.; Bojko, B.; Równicka-Zubik, J.; Sułkowski, W. W.

    2011-11-01

    Interaction of phenylbutazone (PBZ) and aspirin (ASA), two drugs recommended in rheumatoid diseases (RDs), when binding to human (HSA) and bovine (BSA) serum albumins, has been studied by quenching of fluorescence and proton nuclear magnetic resonance ( 1HNMR) techniques. On the basis of spectrofluorescence measurements high affinity binding sites of PBZ and ASA on albumin as well as their interaction within the binding sites were described. A low affinity binding site has been studied by proton nuclear magnetic resonance spectroscopy. Using fluorescence spectroscopy the location of binding site in serum albumin (SA) for PBZ and ASA was found. Association constants Ka were determined for binary (i.e. PBZ-SA and ASA-SA) and ternary complexes (i.e. PBZ-[ASA]-SA and ASA-[PBZ]-SA). PBZ and ASA change the affinity of each other to the binding site in serum albumin (SA). The presence of ASA causes the increase of association constants KaI of PBZ-SA complex. Similarly, PBZ influences KaI of ASA-SA complex. This phenomenon shows that the strength of binding and the stability of the complexes increase in the presence of the second drug. The decrease of KaII values suggests that the competition between PBZ and ASA in binding to serum albumin in the second class of binding sites occurs. The analysis of 1HNMR spectral parameters i.e. changes of chemical shifts and relaxation times of the drug indicate that the presence of ASA weakens the interaction of PBZ with albumin. Similarly PBZ weakens the interaction of ASA with albumin. This conclusion points to the necessity of using a monitoring therapy owning to the possible increase of uncontrolled toxic effects.

  10. Transcriptomic analysis reveals the metabolic mechanism of L-ascorbic acid in Ziziphus jujuba Mill.

    Directory of Open Access Journals (Sweden)

    Chunmei eZhang

    2016-02-01

    Full Text Available Chinese jujube (Ziziphus jujuba Mill. is the most economically important member of the Rhamnaceae family and contains a high concentration of ascorbic acid (AsA. To explore the metabolic mechanism of AsA accumulation, we investigated the abundance of AsA in the fruit development stages, the leaf and flower of Z. jujuba cv Junzao, and the mature fruit of one type of wild jujube (Z. jujuba var. spinosa Hu, Yanchuan sour jujube. And the expression patterns of genes involved in AsA biosynthesis, degradation and recycling were analyzed. The result showed that AsA biosynthesis during early fruit development (the enlargement stage is the main reason for jujube high accumulation. The L-galactose pathway plays a predominant role in the biosynthesis of AsA during jujube fruit development, and the genes GMP1, GME1, GGP, and GaLDH involved in the determination of AsA concentration during fruit development and in different genotypes; the myo-inositol pathway along with the genes GME2 and GMP2 in the L-galactose pathway play a compensatory role in maintaining AsA accumulation during the ripening stage. These findings enhance our understanding of the molecular mechanism in regulating AsA accumulation for jujube.

  11. Effects of very low versus standard dose acetyl salicylic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man.

    Science.gov (United States)

    Lorenz, R; Siess, W; Weber, P C

    1981-04-01

    The effects of three conventional antiplatelet regimes, dipyridamole 3 X 75 mg/day (D), sulfinpyrazone 4 X 200 mg/day (S), acetylsalicylic acid 3 X 330 mg/day combined with dipyridamole 3 X 75 mg/day (ASA + D), and very low dose acetylsalicylic acid 100 mg/day (ASA) on platelet function were studied in man following 4 days of treatment. D and S slightly increased mean minimal ADP concentration for irreversible aggregation (n.s.), S reduced aggregation and thromboxane (TXB2) formation on low dose collagen (2P less than or equal to 0.05), ASA and ASA + D increased platelet count (2P less than or equal to 0.05), increased bleeding time (n.s. for ASA, 2P less than or equal to 0.05 for ASA + D), abolished irreversible aggregation on ADP, suppressed TXB2 formation on all (2P less than or equal to 0.001) and aggregation on lower concentrations of collagen (2P less than or equal to 0.01) and abolished aggregation and TXB2 formation on arachidonic acid (2P less than or equal to 0.001). Very low dose ASA suppresses platelet aggregation and TXB2 formation on several stimuli of possible physiologic significance. In the light of a recently proposed critical balance of vascular antiaggregatory prostacyclin and platelet proaggregatory TXA2 very low dose ASA might offer advantages over conventional dosage of ASA and should be evaluated in thromboembolic disorders. PMID:7238575

  12. Colon-specific drug delivery systems based on cyclodextrin prodrugs: In vivo evaluation of 5-aminosalicylic acid from its cyclodextrin conjugates

    Institute of Scientific and Technical Information of China (English)

    Mei-Juan Zou; Gang Cheng; Hirokazu Okamoto; Xiu-Hua Hao; Feng An; Fu-De Cui; Kazumi Danjo

    2005-01-01

    AIM: To investigate the release of cyclodextrin-5-amino salicylic acid (CyD-5-ASA) in cecum and colon.METHODS: An anti-inflammatory drug 5-ASA was conjugated onto the hydroxyl groups of α-, β- and γ-cyclodextrins (CyDs) through an ester linkage, and the in vivo drug release behavior of these prodrugs in rat' s gastrointestinal tract after the oral administration was investigated.RESULTS: The 5-ASA concentration in the rat's stomach and small intestine after the oral administration of CyD5-ASA conjugate was much lower than that after the oral administration of 5-ASA alone. The lower concentration was attributable to the passage of the conjugate throughthe stomach and small intestine without significant degradation or absorption, followed by the degradation of the conjugate site-specific in the cecum and colon. The oral administration of CyD-5-ASA resulted in lower plasma and urine concentration of 5-ASA than that of 5-ASA alone.CONCLUSION: CyD-5-ASA conjugates may be used as prodrugs for colon-specific drug delivery system.

  13. Kinetics, intermediates and acute toxicity of arsanilic acid photolysis.

    Science.gov (United States)

    Zhu, Xiang-Dong; Wang, Yu-Jun; Liu, Cun; Qin, Wen-Xiu; Zhou, Dong-Mei

    2014-07-01

    Arsanilic acid (4-amino phenyl arsenic acid, ASA) is widely used in poultry production as feed additives, while most of ASA in the feed is excreted in the animal manure and released into the environment. However, the environmental behaviors of ASA were not well understood. In the present study, the photolysis behaviors of ASA and the toxicity of its metabolites to luminescent bacterium were studied. The results showed that ASA could be photodegraded and this process was strongly affected by solution pH, humic acid and dissolved oxygen. Upon UV irradiation for 360 min, ASA could be completely eliminated, but the reduction of total organic carbon (TOC) was not significant. In addition, NH4(+) ions and inorganic arsenic including arsenite and arsenate were identified as the predominant end-products. The conversion of ASA included both direct and indirect photolysis involving radicals, and its possible photolysis pathways were proposed on the basis of the identified intermediates. Unfortunately, higher adverse effects of the conversion products of ASA on bacteria were observed during the photolysis reaction. The results of present study might be helpful for assessing the environmental persistence and risks of ASA. PMID:24405966

  14. Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis.

    Science.gov (United States)

    Nishio, Takashi; Usami, Mai; Awaji, Mizuki; Shinohara, Sumire; Sato, Kazuomi

    2016-01-01

    Acetylsalicylic acid (ASA) is widely used as an analgesic/antipyretic drug. It exhibits a wide range of biological effects, including preventative effects against heart attack and stroke, and the induction of apoptosis in various cancer cells. We previously found that ASA inhibits melanogenesis in B16 melanoma cells. However, the mechanisms of how ASA down-regulates melanin synthesis remain unclear. Here, we investigated the effect of ASA on melanogenic pathways, such as extracellular signal-regulated kinase (ERK) and microphthalmia-associated transcription factor (Mitf) transcription. ASA significantly inhibited melanin synthesis in a dose-dependent manner without oxidative stress and cell death. Semi-quantitative reverse transcription-polymerase chain reaction analysis showed that the inhibitory effect of ASA might be due to the inhibition of Mitf gene transcription. Interestingly, ASA also induced ERK phosphorylation. Additionally, treatment with PD98059, a specific ERK phosphorylation inhibitor, abolished the anti-melanogenic effect of ASA. These results suggest that the depigmenting effect of ASA results from down-regulation of Mitf, which is induced by both the induction of ERK phosphorylation and the inhibition of Mitf transcription. PMID:26699907

  15. A Performance Assessment of a Tactical Airborne Separation Assistance System using Realistic, Complex Traffic Flows

    Science.gov (United States)

    Smith, Jeremy C.; Neitzke, Kurt W.; Bussink, Frank J. L.

    2008-01-01

    This paper presents the results from a study that investigates the performance of aspects of an Airborne Separation Assistance System (ASAS) under varying demand levels using realistic traffic patterns. This study only addresses the tactical aspects of an ASAS using aircraft state data (latitude, longitude, altitude, heading and speed) to detect and resolve projected conflicts. The main focus of this paper is to determine the extent to which sole reliance on the proposed tactical ASAS can maintain aircraft separation at demand levels up to three times current traffic. The effect of mixing ASAS equipped aircraft with non-equipped aircraft that do not have the capability to self-separate is also investigated.

  16. Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?

    Science.gov (United States)

    Demirel, Can; Kilciksiz, Sevil Cagiran; Gurgul, Serkan; Erdal, Nurten; Yigit, Seyran; Tamer, Lulufer; Ayaz, Lokman

    2016-02-01

    The lung is relatively sensitive to irradiation. It is shown that acetylsalicylic acid (ASA) might reduce oxidative injury and that it has a place in protection from cancer. The aim of this study is to evaluate the potential radioprotective effects of ASA. Whole-body irradiation (6 Gy, single dose) was applied to the rats. Glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) levels in the lung tissue were measured. Control (C), Radiation (R), Radiation + ASA (R + ASA; received irradiation and 25 mg/kg of ASA intraperitoneally (i.p.)), and Radiation + Amifostine (R + WR-2721; received irradiation and 200 mg/kg of WR-2721 i.p.) groups were used. The MPO levels decreased statistically significantly in the group administered ASA. Histopathologically, a radioprotective effect of ASA was more evident in the R + ASA group. ASA is an agent which has not been used as a radioprotector in the clinic yet, and it is worth supporting with more advanced studies. PMID:26276129

  17. Inhibition of Murine Systemic Leishmaniasis by Acetyl Salicylic Acid Via Nitric Oxide Immunomodulation

    Directory of Open Access Journals (Sweden)

    M Assmar

    2012-06-01

    Full Text Available Background: The purpose of this study was to evaluate antileishmanial effects of ASA via NO pathway in Leishmania major infected Balb/c mice. Moreover, toxicity and pathological consequences of ASA administration were investigated.Methods: Balb/c mice were infected with L. major and ASA was inoculated orally after lesion appearance for its ability to modulate NO and to modify Leishmania infection in host, in order to evaluate the effects of NO production on size and lesion macroscopy, delay of lesion formation and proliferation of amasti­gotes inside macrophages. Liver, spleen, and lymph nodes were also studied as target organs to detect amastigotes. In addition, plasma was investigated for NO induction using Griess microassay.Results: ASA increased NO production in plasma of both naïve and Leishmania test groups at the ultimate of the experimental period. A decline was observed in proliferation of amastigotes inside macrophages of test group when compared with control one. ASA reduced lesion size, inhibited Leishma­nia visceralisation in spleen, lymph node, and decreased hepato/splenomegaly in ASA treated animals.Conclusions: Some antileishmanial effects of ASA by NO-modulation were indicated during systemic leishmaniasis in mice. Despite slight effects on lesion size, ASA decreased parasite visceralization in target organs and declined their proliferation inside macrophages. Therefore, ASA may be indicated to inhibit systemic leishmaniasis via NO pathway in mice model.

  18. Dicty_cDB: VSF787 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lcviqkvkskvtfsd qsprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---HASRINNVKSTSRR**lqsitrss...iwswlpskrvnqn*erkfalv*lsdkentgrermvftsiskitlvlcviqkvksk vtfsdqsprnapiygqrlppmpvplfk*ih Frame B: asa*imskaqav...ftsiskitlvlcviqkvkskvtfsd qsprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---trpa*imskaqavg

  19. Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis.

    Science.gov (United States)

    Nishio, Takashi; Usami, Mai; Awaji, Mizuki; Shinohara, Sumire; Sato, Kazuomi

    2016-01-01

    Acetylsalicylic acid (ASA) is widely used as an analgesic/antipyretic drug. It exhibits a wide range of biological effects, including preventative effects against heart attack and stroke, and the induction of apoptosis in various cancer cells. We previously found that ASA inhibits melanogenesis in B16 melanoma cells. However, the mechanisms of how ASA down-regulates melanin synthesis remain unclear. Here, we investigated the effect of ASA on melanogenic pathways, such as extracellular signal-regulated kinase (ERK) and microphthalmia-associated transcription factor (Mitf) transcription. ASA significantly inhibited melanin synthesis in a dose-dependent manner without oxidative stress and cell death. Semi-quantitative reverse transcription-polymerase chain reaction analysis showed that the inhibitory effect of ASA might be due to the inhibition of Mitf gene transcription. Interestingly, ASA also induced ERK phosphorylation. Additionally, treatment with PD98059, a specific ERK phosphorylation inhibitor, abolished the anti-melanogenic effect of ASA. These results suggest that the depigmenting effect of ASA results from down-regulation of Mitf, which is induced by both the induction of ERK phosphorylation and the inhibition of Mitf transcription.

  20. American Society of Anesthesiologists

    Science.gov (United States)

    ... Clinical Information From ASA Committees Ethics & Professionalism Education Education Center Group Offerings Practice Management Quality MOCA Live Learning Online Learning Simulation Education Education ...

  1. Characterization of a dextran–coated layered double hydroxide acetylsalicylic acid delivery system and its pharmacokinetics in rabbit

    Directory of Open Access Journals (Sweden)

    Li-e Dong

    2013-12-01

    Full Text Available The aim of this study was to prepare a dextran–coated layered double hydroxide acetylsalicylic acid (DEX–LDH–ASA delivery system by co-precipitation of LDH–ASA and its in-situ compositing with DEX. The structure of the system was investigated using X-ray diffraction (XRD, Fourier transform infrared spectroscopy (FT-IR and thermogravimetry (TG. Its in vitro drug release properties and in vivo pharmacokinetics in rabbit were also determined. The results show that the DEX–LDH–ASA system retained the crystal structure of LDH–ASA and gave a marked improvement in its dispersion. It also prolonged the release of ASA and shifted the release pattern from first-order to zero-order kinetics. The pharmacokinetics of ASA administered in the DEX–LDH–ASA system to rabbits produced two absorption peaks with a Cmax of 14.8±1.7 mg/L at 2.11±0.69 h and an elimination half-life of 2.25±0.84 h for the first peak. The fact that delivery of ASA in the DEX–LDH–ASA system was sustained with improved bioavailability indicates the potential of the system as a controlled release formulation with application to other drugs.

  2. Implications of Altered Glutathione Metabolism in Aspirin-Induced Oxidative Stress and Mitochondrial Dysfunction in HepG2 Cells

    OpenAIRE

    Raza, Haider; John, Annie

    2012-01-01

    We have previously reported that acetylsalicylic acid (aspirin, ASA) induces cell cycle arrest, oxidative stress and mitochondrial dysfunction in HepG2 cells. In the present study, we have further elucidated that altered glutathione (GSH)-redox metabolism in HepG2 cells play a critical role in ASA-induced cytotoxicity. Using selected doses and time point for ASA toxicity, we have demonstrated that when GSH synthesis is inhibited in HepG2 cells by buthionine sulfoximine (BSO), prior to ASA tre...

  3. Inhibitory Effect of Flavonoids on the Efflux of -Acetyl 5-Aminosalicylic Acid Intracellularly Formed in Caco-2 Cells

    Directory of Open Access Journals (Sweden)

    Shin Yoshimura

    2009-01-01

    Full Text Available -acetyl 5-aminosalicylic acid (5-AcASA that was intracellularly formed from 5-aminosalicylic acid (5-ASA at 200 M was discharged 5.3, 7.1, and 8.1-fold higher into the apical site than into the basolateral site during 1, 2, and 4-hour incubations, respectively, in Caco-2 cells grown in Transwells. The addition of flavonols (100 M such as fisetin and quercetin with 5-ASA remarkably decreased the apically directed efflux of 5-AcASA. When 5-ASA (200 M was added to Caco-2 cells grown in tissue culture dishes, the formation of 5-AcASA decreased, and, in addition, the formed 5-AcASA was found to be accumulated within the cells in the presence of such flavonols. Thus, the decrease in 5-AcASA efflux by such flavonols was attributed not only to the inhibition of -acetyl-conjugation of 5-ASA but to the predominant cellular accumulation of 5-AcASA. Various flavonoids also had both of the effects with potencies that depend on their specific structures. The essential structure of flavonoids was an absence of a hydroxyl substitution at the C5 position on the A-ring of flavone structure for the inhibitory effect on the -acetyl-conjugation of 5-ASA, and a presence of hydroxyl substitutions at the C3 or C4 position on the B-ring of flavone structure for the promoting effect on the cellular accumulation of 5-AcASA. Both the decrease in 5-AcASA apical efflux and the increase in 5-AcASA cellular accumulation were also caused by MK571 and indomethacin, inhibitors of MRPs, but not by quinidine, cyclosporin A, P-glycoprotein inhibitors, and mitoxantrone, a BCRP substrate. These results suggest that certain flavonoids suppress the apical efflux of 5-AcASA possibly by inhibiting MRPs pumps located on apical membranes in Caco-2 cells.

  4. Synthesis of L-ascorbic acid in the phloem

    Directory of Open Access Journals (Sweden)

    Haupt Sophie

    2003-11-01

    Full Text Available Abstract Background Although plants are the main source of vitamin C in the human diet, we still have a limited understanding of how plants synthesise L-ascorbic acid (AsA and what regulates its concentration in different plant tissues. In particular, the enormous variability in the vitamin C content of storage organs from different plants remains unexplained. Possible sources of AsA in plant storage organs include in situ synthesis and long-distance transport of AsA synthesised in other tissues via the phloem. In this paper we examine a third possibility, that of synthesis within the phloem. Results We provide evidence for the presence of AsA in the phloem sap of a wide range of crop species using aphid stylectomy and histochemical approaches. The activity of almost all the enzymes of the primary AsA biosynthetic pathway were detected in phloem-rich vascular exudates from Cucurbita pepo fruits and AsA biosynthesis was demonstrated in isolated phloem strands from Apium graveolens petioles incubated with a range of precursors (D-glucose, D-mannose, L-galactose and L-galactono-1,4-lactone. Phloem uptake of D-[U-14C]mannose and L-[1-14C]galactose (intermediates of the AsA biosynthetic pathway as well as L-[1-14C]AsA and L-[1-14C]DHA, was observed in Nicotiana benthamiana leaf discs. Conclusions We present the novel finding that active AsA biosynthesis occurs in the phloem. This process must now be considered in the context of mechanisms implicated in whole plant AsA distribution. This work should provoke studies aimed at elucidation of the in vivo substrates for phloem AsA biosynthesis and its contribution to AsA accumulation in plant storage organs.

  5. Ascorbic acid is a key participant during the interactions between chloroplasts and mitochondria to optimize photosynthesis and protect against photoinhibition

    Indian Academy of Sciences (India)

    Saikrishna Talla; Khateef Riazunnisa; Lolla Padmavathi; Pidakala Rajsheel; Agepati S Raghavendra

    2011-03-01

    The possible role of L-ascorbate (AsA) as a biochemical signal during the interactions between photosynthesis and respiration was examined in leaf discs of Arabidopsis thaliana. AsA content was either decreased as in AsA-deficient vtc1 mutants or increased by treatment with L-galactono-1, 4-lactone (L-GalL, a precursor of AsA; EC 1.3.2.3). In mutants, photosynthesis was extremely sensitive to both antimycin A (inhibitor of the cytochrome oxidase pathway [COX pathway]) and salicylhydroxamic acid (SHAM, inhibitor of the alternative pathway [AOX pathway]), particularly at high light conditions. Mitochondrial inhibitors lowered the ratio of reduced AsA to total AsA, at high light, indicating oxidative stress in leaf discs. Elevation of AsA by L-GalL decreased the sensitivity of photosynthesis at high light to antimycin A or SHAM, sustained photosynthesis at supraoptimal light and relieved the extent of photoinhibition. High ratios of reduced AsA to total AsA in L-GalL-treated leaf discs suggests that L-GalL lowers oxidative stress. The protection by L-GalL of photosynthesis against the mitochondrial inhibitors and photoinhibition was quite pronounced in vtc1 mutants. Our results suggest that the levels and redox state of AsA modify the pattern of modulation of photosynthesis by mitochondrial metabolism. The extent of the AOX pathway as a percentage of the total respiration in Arabidopsis mesophyll protoplasts was much higher in vtc1 than in wild type. We suggest that the role of AsA becomes pronounced at high light and/or when the AOX pathway is inhibited. While acknowledging the importance of the COX pathway, we hypothesize that AsA and the AOX pathway may complement each other to protect photosynthesis against photoinhibition.

  6. Simultaneous extraction of acetylsalicylic acid and salicylic acid from human plasma and simultaneous estimation by liquid chromatography and atmospheric pressure chemical ionization/tandem mass spectrometry detection. Application to a pharmacokinetic study.

    Science.gov (United States)

    Nirogi, Ramakrishna; Kandikere, Vishwottam; Mudigonda, Koteshwara; Ajjala, Devender; Suraneni, Ramakrishna; Thoddi, Parthasarathi

    2011-01-01

    A simple analytical method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in atmospheric chemical ionization mode (APCI) for the simultaneous estimation of acetylsalicylic acid (ASA, CAS 50-78-2) and its active metabolite salicylic acid (SA, CAS 69-72-7) in human plasma has been developed and validated. ASA and SA were analyzed simultaneously despite differences in plasma concentration ranges of ASA and SA after oral administration of ASA. In spite of having different chemical, ionization and chromatographic properties, ASA and SA were extracted simultaneously from the plasma sample using acetonitrile protein precipitation followed by liquid-liquid extraction. The analytes were separated on a reversed phase column with rapid gradient program using mobile phase consisting of ammonium acetate buffer and methanol. The structural analogue diclofenac was used as an internal standard. The multiple reaction monitoring (MRM) transitions m/z 179 --> 137 for ASA, m/z 137 --> 65 for SA and m/z 294 --> 250 for IS were used. The assay exhibited a linear dynamic range of 0.02-10 microg/mL for ASA and 0.1-50 microg/mL for SA. The between-batch precision (%CV) ranged from 2.1 to 7.9% for ASA and from 0.2 to 5.2% for SA. The between-batch accuracy ranged from 95.4 to 96.7% for ASA and from 94.6 to 111.3% for SA. The validated method was successfully applied for the evaluation of pharmacokinetics of ASA after single oral administration of 650 mg test formulation versus two 325 mg reference formulations of ASA in human subjects. PMID:21755814

  7. Effect of Erythropoietin Carried by Stearic Acid-Grafted Chitosan Micelle on Epilepsy Seizure in Mice%促红细胞生成素胶束给药系统对小鼠癫痫的影响

    Institute of Scientific and Technical Information of China (English)

    曹高扬; 胡薇薇; 俞栋栋; 于亚赛; 谢贻珽; 袁弘; 陆源; 厉旭云; 戴海斌; 陈忠

    2013-01-01

    探讨载促红细胞生成素的壳聚糖-硬脂酸(CS-SA)胶束给药系统对戊四唑诱导的小鼠癫痫的影响.小鼠给予载人重组促红细胞生成素的壳聚糖-硬脂酸(r-HuEPO-CS-SA)胶束制剂和r-HuEPO普通制剂24 h后,观察对戊四唑(PTZ)诱导的急性癫痫模型中发作潜伏时间、发作级别、大发作持续时间以及次数的影响.此外,小鼠隔天注射r-HuEPO-CS-SA胶束制剂和普通制剂,观察对PTZ诱导的癫痫形成过程的影响.结果:在PTZ急性模型中,给予r-HuEPO普通制剂仅4 000 IU/kg剂量组在降低发作级别、减少大发作持续时间和减少发作次数方面有显著差异(P<0.05).而给予r-HuEPO-CSCS-SA胶束制剂2 000 IU/kg就可显著增加潜伏时间,降低大发作持续时间(P<0.05).并且给予r-HuEPO-CS-SA胶束制剂4 000 IU/kg、8 000 IU/kg,在延长潜伏时间、降低发作级别、减少大发作持续时间和减少发作次数方面均有显著差异(P<0.05).但在慢性癫痫点燃过程中,给予r-HuEPO-CS-SA胶束制剂和普通制剂均不能缓解癫痫形成的进程.本研究表明r-HuEPO-CS-SA胶束制剂可以显著缓解PTZ诱导的急性癫痫发作,作用较r-HuEPO普通制剂更明显,但对于PTZ诱导的癫痫形成过程无明显作用,提示载促红细胞生成素的CS-SA胶束给药系统有望更好的用于防治癫痫发作.%To study the effect of erythropoietin carried by stearic acid-grafted chitosan ( CS-SA) micelle on pentylenetetrazol (PTZ)-induced seizure in mice, in PTZ induced acute seizure model, the seizure latency, stage, seizure duration, and number of convulsive episodes were recorded at 24 h after administration of r-HuEPO ( recombinant human erythropoietin) carried by CS-SA micelle or r-HuEPO common formulation. The development of PTZ-induced kindling was examined after administration of r-HuEPO carried by CS-SA micelle or r-HuEPO common formulation every other day. The results showed that the administration of r

  8. SUBSTITUTION OF HIGH-YIELD-PULP FOR HARDWOOD BLEACHED KRAFT PULP IN PAPER PRODUCTION AND ITS EFFECT ON ALKENYL SUCCINIC ANHYDRIDE SIZING

    Directory of Open Access Journals (Sweden)

    Qijie Chen,

    2012-02-01

    Full Text Available In recent years there has been an increasing interest in using high-yield pulp (HYP as a partial replacement for hardwood bleached kraft pulp (HWBKP in the production of high-quality fine papers as a cost-effective way of improving the product performance. This study investigated the substitution of HYP for HWBKP and its effect on the Alkenyl Succinic Anhydride (ASA sizing performance. The results showed that the substitution of an aspen HYP for HWBKP can increase the ASA sizing performance at a HYP substitution as high as 15 to 20%. The ASA addition sequence has an influence on the ASA sizing performance and first adding ASA to the HYP followed by mixing with kraft pulps was the preferred method. Using precipitated calcium carbonate (PCC as a paper filler at a dosage of less than 20% can increase the ASA sizing performance due to the contribution of the calcium soap of the hydrolysed ASA. A PCC dosage greater than 20% resulted in a negative impact on the sizing performance. It was also found that different PCC loading sequences can also affect the ASA sizing performance.

  9. Reduced activity of arylsulfatase A and predisposition to neurological disorders: analysis of 140 pediatric patients.

    Science.gov (United States)

    Sangiorgi, S; Ferlini, A; Zanetti, A; Mochi, M

    1991-09-01

    A sample of 140 children exhibiting neurologic disturbances (93 suffering from epilepsy and 47 with delayed psychomotor development or mental retardation) was tested for the activity of some lysosomal enzymes. A partial deficiency of arylsulfatase A (ASA) in leucocytes (activities lower than 60% of the control average) was detected in 36 patients (25.7%), whereas few ASA-deficient individuals (1.4%) were found in the control sample of 71 healthy children. Therefore, the frequency of ASA deficiency is abnormally high in our sample of pediatric patients. ASA activity levels were also assayed on fibroblasts from 12 of the 36 ASA-deficient patients; the mean activity in these cells was 20% of the control average. Excretion of urinary sulfatides was not increased in the tested ASA-deficient patients (10/36). Clinical symptoms of these ASA-deficient patients bore no resemblance to classical metachromatic leucodystrophy (MLD), but resemble literature cases labeled as atypical MLD or diagnostic puzzles. This result suggests that reduced ASA activity might be associated with an increased risk of developing neurologic or neuropsychiatric disturbances in children. PMID:1683156

  10. Low-dose aspirin and rupture of abdominal aortic aneurysm

    DEFF Research Database (Denmark)

    Wemmelund, Holger; Jørgensen, Trine M M; Høgh, Annette;

    2016-01-01

    OBJECTIVE: The use of low-dose aspirin (acetylsalicylic acid [ASA]) has been suggested to attenuate growth of abdominal aortic aneurysms (AAAs), yet solid clinical evidence of this hypothesis is still missing. This study aimed to investigate whether preadmission ASA use influenced the risk of...

  11. Atrioventricular conduction after alcohol septal ablation for obstructive hypertrophic cardiomyopathy

    DEFF Research Database (Denmark)

    Axelsson, Anna; Weibring, Kristina; Havndrup, Ole;

    2014-01-01

    AIMS: Lesion of the atrioventricular conduction system is a well known adverse effect of alcohol septal ablation (ASA) in patients with obstructive hypertrophic cardiomyopathy (HCM). We assessed the atrioventricular conduction at long-term follow-up after ASA. METHODS: In patients with a pacemaker...

  12. Sexual revictimization in a clinical sample of women reporting childhood sexual abuse

    DEFF Research Database (Denmark)

    Lau, Marianne; Kristensen, Ellids

    2010-01-01

    BACKGROUND: Child and adolescent sexual abuse (CSA) increases the risk for adult sexual assault (ASA), and psychological vulnerability as well as aspects of CSA and upbringing might influence the risk. AIMS: The aims of this study were to investigate whether women who reported both CSA and ASA: 1...

  13. Low risk of pelvic sepsis after intersphincteric proctectomy in patients with low rectal cancer

    DEFF Research Database (Denmark)

    Eriksen, Marianne H; Maina, Pierre; Jensen, Kenneth Højsgaard

    2014-01-01

    (28%), ASA 2 (60%), and ASA 3 (12%); their tumour-node-metastasis (TNM) staging was TNM: ≤ T2 (30%), T3 (50%), and T4 (20%); and 26% had received neoadjuvant radiotherapy, whereas 40% had received chemotherapy. A total of three patients (6%) developed a post-operative pelvic sepsis. The median length...

  14. Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.

    Science.gov (United States)

    Kurahashi, Toshihiro; Lee, Jaeyong; Nabeshima, Atsunori; Homma, Takujiro; Kang, Eun Sil; Saito, Yuka; Yamada, Sohsuke; Nakayama, Toshiyuki; Yamada, Ken-Ichi; Miyata, Satoshi; Fujii, Junichi

    2016-08-15

    Aldehyde reductase (AKR1A) plays a role in the biosynthesis of ascorbic acid (AsA), and AKR1A-deficient mice produce about 10-15% of the AsA that is produced by wild-type mice. We found that acetaminophen (AAP) hepatotoxicity was aggravated in AKR1A-deficient mice. The pre-administration of AsA in the drinking water markedly ameliorated the AAP hepatotoxicity in the AKR1A-deficient mice. Treatment of the mice with AAP decreased both glutathione and AsA levels in the liver in the early phase after AAP administration, and an AsA deficiency delayed the recovery of the glutathione content in the healing phase. While in cysteine supply systems; a neutral amino acid transporter ASCT1, a cystine transporter xCT, enzymes for the transsulfuration pathway, and autophagy markers, were all elevated in the liver as the result of the AAP treatment, the AsA deficiency suppressed their induction. Thus, AsA appeared to exert a protective effect against AAP hepatotoxicity by ameliorating the supply of cysteine that is available for glutathione synthesis as a whole. Because some drugs produce reactive oxygen species, resulting in the consumption of glutathione during the metabolic process, the intake of sufficient amounts of AsA would be beneficial for protecting against the hepatic damage caused by such drugs. PMID:27288086

  15. Acetylsalicylic acid induces programmed cell death in Arabidopsis cell cultures.

    Science.gov (United States)

    García-Heredia, José M; Hervás, Manuel; De la Rosa, Miguel A; Navarro, José A

    2008-06-01

    Acetylsalicylic acid (ASA), a derivative from the plant hormone salicylic acid (SA), is a commonly used drug that has a dual role in animal organisms as an anti-inflammatory and anticancer agent. It acts as an inhibitor of cyclooxygenases (COXs), which catalyze prostaglandins production. It is known that ASA serves as an apoptotic agent on cancer cells through the inhibition of the COX-2 enzyme. Here, we provide evidences that ASA also behaves as an agent inducing programmed cell death (PCD) in cell cultures of the model plant Arabidopsis thaliana, in a similar way than the well-established PCD-inducing agent H(2)O(2), although the induction of PCD by ASA requires much lower inducer concentrations. Moreover, ASA is herein shown to be a more efficient PCD-inducing agent than salicylic acid. ASA treatment of Arabidopsis cells induces typical PCD-linked morphological and biochemical changes, namely cell shrinkage, nuclear DNA degradation, loss of mitochondrial membrane potential, cytochrome c release from mitochondria and induction of caspase-like activity. However, the ASA effect can be partially reverted by jasmonic acid. Taking together, these results reveal the existence of common features in ASA-induced animal apoptosis and plant PCD, and also suggest that there are similarities between the pathways of synthesis and function of prostanoid-like lipid mediators in animal and plant organisms.

  16. Identification of major degradation products of 5-aminosalicylic acid formed in aqueous solutions and in pharmaceuticals

    DEFF Research Database (Denmark)

    Jensen, J.; Cornett, Claus; Olsen, C. E.;

    1992-01-01

    The formation of four major degradation products of 5-aminosalicylic acid (5-ASA) in buffered solutions at pH 7.0 was demonstrated by gradient HPLC analysis. The isolation and structural elucidation of the resulting degradation products showed that the degradation of 5-ASA led to the formation...

  17. Academic help seeking, social academic self-efficacy and class-related emotions in university students

    OpenAIRE

    Sánchez Rosas, Javier

    2013-01-01

    A cross-sectional study examined whether (a) are there relations between academic help-seeking (BAA), social academic self-efficacy (ASA) and achievement emotions in a sample of university students (N = 433) and (b) are there gender differences across the studied variables (N=180). Partial correlations between ASA with enjoyment, hope, anxiety and shame were found (r=.19, .12, -.13, -.38; p

  18. Long-term clinical outcome after alcohol septal ablation for obstructive hypertrophic cardiomyopathy

    DEFF Research Database (Denmark)

    Veselka, Josef; Jensen, Morten Kvistholm; Liebregts, Max;

    2016-01-01

    AIMS: The first cases of alcohol septal ablation (ASA) for obstructive hypertrophic cardiomyopathy (HCM) were published two decades ago. Although the outcomes of single-centre and national ASA registries have been published, the long-term survival and clinical outcome of the procedure are still...

  19. Laparoscopic partial nephrectomy for endophytic hilar tumors

    DEFF Research Database (Denmark)

    Di Pierro, G B; Tartaglia, N; Aresu, L;

    2014-01-01

    To analyze feasibility and outcomes of laparoscopic partial nephrectomy (LPN) for endophytic hilar tumors in low-intermediate (ASA I-II) risk patients.......To analyze feasibility and outcomes of laparoscopic partial nephrectomy (LPN) for endophytic hilar tumors in low-intermediate (ASA I-II) risk patients....

  20. ANTISPERM ANTIBODY IS A POSSIBLE CAUSE OF SPONTANEOUS ABORTION

    Institute of Scientific and Technical Information of China (English)

    XUChong; CHENFu; LIULi; ZHAOFei-Sha

    1989-01-01

    To clarify the possible correlation between antisperm antibodies (ASA) and spontaneous abortion, 68 women, aged 23-37, experienced 2-9 times of spontaneous abortion were tested for ASA by ELISA. 38 fertile women, aged 24-40, without history of abortion were employed as control.

  1. Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells

    OpenAIRE

    Rocha, Gerson M.; Michea, Luis F.; Peters, Eugenia M.; Kirby, Martha; Xu, Yuhui; Ferguson, Douglas R.; Burg, Maurice B.

    2001-01-01

    Antipyretic analgesics, taken in large doses over a prolonged period, cause a specific form of kidney disease, characterized by papillary necrosis and interstitial scarring. Epidemiological evidence incriminated mixtures of drugs including aspirin (ASA), phenacetin, and caffeine. The mechanism of toxicity is unclear. We tested the effects of ASA, acetaminophen (APAF, the active metabolite of phenacetin), caffeine, and other related drugs individually and in combination...

  2. Synthesis and structural elucidation of glutathione and N-aceyl-cysteine conjugates of 5-aminosalicylic acid

    DEFF Research Database (Denmark)

    Jensen, J.; Cornett, Claus; Olsen, C. E.;

    1993-01-01

    The ability of 5-aminosalicylic acid (5-ASA) to be oxidized to a quinone monoimine compound capable of conjugating with nucleophilic compounds such as N-acetyl-cysteine (NAC) and glutathione (GSH) has been investigated in vitro. Three isomeric conjugates of 5-ASA and NAC as well as three isomeric...... conjugates of 5-ASA and GSH were found to be formed. 5-ASA was initially oxidized by PbO2 in a solution of TRIS-HCl buffer pH 9.3 followed by the in situ addition of N-acetyl-cysteine or glutathione to the oxidized 5-ASA at pH 7.5. The resulting conjugates were N-acetylated at the aromatic amino group in...

  3. The prophylactic effect of 5-aminosalicylic acid and salazosulphapyridine on degraded-carrageenan-induced colitis in guinea pigs

    DEFF Research Database (Denmark)

    Poulsen, Steen Seier

    1984-01-01

    Experimental colitis was induced in guinea pigs by administration of 5% degraded carrageenan for 5 days. The prophylactic effect of a slow-release preparation of 5-aminosalicylic acid (5-ASA; 13 mg/100 g/day) was compared with approximately equimolar amounts of salazosulphapyridine (SASP; 26 mg/100...... g/day) and placebo. Treatment was started 2 days before initiation of carrageenan administration. The drugs were administered through a chronic gastric fistula. At the end of the study concentrations of 5-ASA and acetylated 5-ASA (Ac-5-ASA) in cecal contents and in plasma were determined...... difference between the human ulcerative colitis and the carrageenan model may account for the lack of prophylactic effect of the slow-release 5-ASA in this experiment....

  4. PREVENTION OF THROMBOSES IN ANTIPHOSPHOLIPID SYNDROME

    Directory of Open Access Journals (Sweden)

    Lyubov Valeryevna Kondratyeva

    2009-01-01

    Patients with antiphospholipid (aPL antibodies and venous thromboses need long-term moderate-intensity warfarin therapy. Patients with ischemic strokes without other indications for the use of anticoagulants may be given either warfarin or ASA. In the latter case, there is no need for laboratory control or an individual dose adjustment. The primary prevention of thromboses in the presence of aPL is also performed with ASA. When pregnancy occurs, women with obstetric manifestations of APS may be given small-dose ASA in combination with heparins. To reduce the risk of hemorrhages, warfarin dosage adjustment is initiated with the minimum doses (<5 mg/day. Novel ASA formulations, such as ASA with the unabsorbed antacid magnesium hydroxide, have been developed to prevent gastrointestinal tract complications.

  5. Aspirin for cancer is no mere antiplatelet prototype. There is potential in its ancient roots.

    Science.gov (United States)

    Lawrence, James R; Baxter, Gwendoline J; Paterson, John R

    2016-09-01

    Aspirin (ASA), increasingly accepted as predominantly a cyclooxygenase (COX)-1 inhibitor, is a prodrug for salicylic acid (SA) which has no such activity. SA is widespread in nature, vital in plants, and present in drug free serum from animals and man. Evolutionary conserved SA receptors are found in human tissues. Very low doses of ASA will, on repeat dosing, produce near maximal platelet COX-1 inhibition. Evidence for cancer prophylaxis is based on ASA doses of at least 75mg/day. Pleiotropic mechanisms underlie low dose ASA's undoubted efficacy in preventive medicine but the key barrier to its more widespread use is gastrointestinal toxicity. ASA/SA combination formulations may improve the current risk/benefit ratio of chemo-prophylactic preparations. There is well established methodology for, and should be few regulatory barriers to, their evaluation. PMID:27515206

  6. High temperature inhibits ascorbate recycling and light stimulation of the ascorbate pool in tomato despite increased expression of biosynthesis genes.

    Directory of Open Access Journals (Sweden)

    Capucine Massot

    Full Text Available Understanding how the fruit microclimate affects ascorbate (AsA biosynthesis, oxidation and recycling is a great challenge in improving fruit nutritional quality. For this purpose, tomatoes at breaker stage were harvested and placed in controlled environment conditions at different temperatures (12, 17, 23, 27 and 31 °C and irradiance regimes (darkness or 150 µmol m(-2 s(-1. Fruit pericarp tissue was used to assay ascorbate, glutathione, enzymes related to oxidative stress and the AsA/glutathione cycle and follow the expression of genes coding for 5 enzymes of the AsA biosynthesis pathway (GME, VTC2, GPP, L-GalDH, GLDH. The AsA pool size in pericarp tissue was significantly higher under light at temperatures below 27 °C. In addition, light promoted glutathione accumulation at low and high temperatures. At 12 °C, increased AsA content was correlated with the enhanced expression of all genes of the biosynthesis pathway studied, combined with higher DHAR and MDHAR activities and increased enzymatic activities related to oxidative stress (CAT and APX. In contrast, at 31 °C, MDHAR and GR activities were significantly reduced under light indicating that enzymes of the AsA/glutathione cycle may limit AsA recycling and pool size in fruit pericarp, despite enhanced expression of genes coding for AsA biosynthesis enzymes. In conclusion, this study confirms the important role of fruit microclimate in the regulation of fruit pericarp AsA content, as under oxidative conditions (12 °C, light total fruit pericarp AsA content increased up to 71%. Moreover, it reveals that light and temperature interact to regulate both AsA biosynthesis gene expression in tomato fruits and AsA oxidation and recycling.

  7. Antioxidant Vitamin Status in the Serum and Amniotic Fluid of Women with Premature Rupture of the Fetal Membranes.

    Science.gov (United States)

    Barrett, Bridget M.

    The purpose of this study was to examine the status of antioxidant vitamins in women with premature rupture of the fetal membranes. Specimens of blood and amniotic fluid were obtained from 80 pregnant subjects included both smokers and non-smokers during the third trimester. The concentrations of ascorbic acid (ASA), beta -carotene, retinol and alpha -tocopherol in serum and amniotic fluid were determined. The experimental group consisted of those subjects with PROM while the control subjects were those with normal pregnancy. No statistical differences were found between the PROM and control groups in retinol and vitamin E concentrations in amniotic fluid and serum. Serum ASA concentrations of PROM subjects were not different from controls, but the PROM subjects had significantly lower amniotic fluid ASA concentrations. However, in a study with fewer subjects a lower serum ASA concentration in the PROM subjects was observed. The ratio of amniotic fluid ASA concentration to ASA serum concentration was significantly lower in PROM patients than in controls in both studies. This suggests that low levels of ASA in the amniotic fluid, but not in serum is better associated with PROM. A low amniotic fluid concentration of ASA may reflect an inefficient transfer and/or increased fetal utilization. Alterations in ASA concentration in the amniotic fluid may affect the integrity of the chorioamnion leading to PROM. beta -Carotene was not found in the amniotic fluid. Serum beta-carotene levels were significantly lower in the PROM group compared to the control group. Low concentrations of beta-carotene in maternal serum in smokers not only associated with poor maternal outcome (PROM) but also compromised the fetal outcome (decreased birth weight). Maintenance of adequate serum beta-carotene concentration and amniotic fluid ASA in smokers may result in better maternal and fetal outcome. This study demonstrated that nutrition is an important factor in the prevention of PROM.

  8. Spectroscopic studies of the interaction of aspirin and its important metabolite, salicylate ion, with DNA, A·T and G·C rich sequences

    Science.gov (United States)

    Bathaie, S. Z.; Nikfarjam, L.; Rahmanpour, R.; Moosavi-Movahedi, A. A.

    2010-12-01

    Among different biological effects of acetylsalicylic acid (ASA), its anticancer property is controversial. Since ASA hydrolyzes rapidly to salicylic acid (SA), especially in the blood, interaction of both ASA and SA (as the small molecules) with ctDNA, oligo(dA·dT) 15 and oligo(dG·dC) 15, as a possible mechanism of their action, is investigated here. The results show that the rate of ASA hydrolysis in the absence and presence of ctDNA is similar. The spectrophotometric results indicate that both ASA and SA cooperatively bind to ctDNA. The binding constants ( K) are (1.7 ± 0.7) × 10 3 M -1 and (6.7 ± 0.2) × 10 3 M -1 for ASA and SA, respectively. Both ligands quench the fluorescence emission of ethidium bromide (Et)-ctDNA complex. The Scatchard plots indicate the non-displacement based quenching (non-intercalative binding). The circular dichroism (CD) spectra of ASA- or SA-ctDsNA complexes show the minor distortion of ctDNA structure, with no characteristic peaks for intercalation of ligands. Tm of ctDNA is decreased up to 3 °C upon ASA binding. The CD results also indicate more distortions on oligo(dG·dC) 15 structure due to the binding of both ASA and SA in comparison with oligo(dA·dT) 15. All data indicate the more affinity for SA binding with DNA minor groove in comparison with ASA which has more hydrophobic character.

  9. Pharmacokinetics and Brain Uptake in the Rhesus Monkey of a Fusion Protein of Arylsulfatase A and a Monoclonal Antibody Against the Human Insulin Receptor

    Science.gov (United States)

    Boado, Ruben J.; Lu, Jeff Zhiqiang; Hui, Eric K.-W.; Sumbria, Rachita K.; Pardridge, William M.

    2014-01-01

    Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder of the brain caused by mutations in the gene encoding the lysosomal sulfatase, arylsulfatase A (ASA). It is not possible to treat the brain in MLD with recombinant ASA, because the enzyme does not cross the blood-brain barrier (BBB). In the present investigation, a BBB-penetrating IgG-ASA fusion protein is engineered and expressed, where the ASA monomer is fused to the carboxyl terminus of each heavy chain of an engineered monoclonal antibody (MAb) against the human insulin receptor (HIR). The HIRMAb crosses the BBB via receptor-mediated transport on the endogenous BBB insulin receptor, and acts as a molecular Trojan horse to ferry the ASA into brain from blood. The HIRMAb-ASA is expressed in stably transfected Chinese hamster ovary cells grown in serum free medium, and purified by protein A affinity chromatography. The fusion protein retains high affinity binding to the HIR, EC50 = 0.34 ± 0.11 nM, and retains high ASA enzyme activity, 20 ± 1 units/mg. The HIRMAb-ASA fusion protein is endocytosed and triaged to the lysosomal compartment in MLD fibroblasts. The fusion protein was radio-labeled with the Bolton-Hunter reagent, and the [125I]-HIRMAb-ASA rapidly penetrates the brain in the Rhesus monkey following intravenous administration. Film and emulsion autoradiography of primate brain shows global distribution of the fusion protein throughout the monkey brain. These studies describe a new biological entity that is designed to treat the brain of humans with MLD following non-invasive, intravenous infusion of an IgG-ASA fusion protein. PMID:23192358

  10. Interaction of 4-aminosalieylic Acid and Surfactants in Aqueous Solutions Using UV-Vis Spectra and Steady-state Fluorescence Spectroscopy

    Institute of Scientific and Technical Information of China (English)

    XU Dongying; REN Jiaoyan; LIAO Zhengfu; WANG Hui; ZHAO Mouming; LI Guangji

    2011-01-01

    The interactions of 4-aminosalicylic acid (4-ASA) and surfactants in aqueous solutions were investigated by using UV-Vis spectra and steady-state fluorescence spectroscopy.The results showed that the strongest peak at UV-vis spectra of 4-ASA aqueous solution in the presence of cationic surfactant and cetyltrimethyl ammonium bromide (CTAB) appeared at 206 nm and took.a red shift from 206 nm to 221 nm with the increase of 4-ASA concentrations from 0.8× 10-5 to 4.4× 10-4 mol/L.Similarly,the strongest peak at UV-vis spectra of 4-ASA aqueous solution in the presence of nonionic surfactant and polyvinylpyrrolidone (PVP)appeared at 206 nm and took a red shift from 206 nm to 219 nm with the increase of 4-ASA concentrations from 0.8× 10-5 to 4.4x 10-4 mol/L.However,the similar phenomena did not appeared in the presence of anion surfactant,sodium dodecyl sulfate (SDS),the UV-vis spectra of 4-ASA aqueous solution remained the same peak position and the peak value increased with the 4-ASA concentration increase.The results could be attributed to the electrostatic attraction between 4-ASA and CTAB or PVP,as well as the electrostatic repulsion between 4-ASA and SDS.Furthermore,the value of critical micelle concentration (CMC) of surfactants in the presence of 4-ASA was determined with Fluorescence method.The first and second CMC of CTAB was 1.2×10-4 M and 2.4x10-4 M,respectively.The first and second CMC of PVP was 1.2×10 4 M and 2.8x 10 4 M.SDS realized the multiple micellizations to form multiple CMC.

  11. Protective Role of Acetylsalicylic Acid in Experimental Trypanosoma cruzi Infection: Evidence of a 15-epi-Lipoxin A4-Mediated Effect

    Science.gov (United States)

    Henriquez, Natalia; Faúndez, Mario; Torres, Gloria; Castillo, Christian; Escanilla, Sebastián; Kemmerling, Ulrike; Morello, Antonio; López-Muñoz, Rodrigo A.; Maya, Juan D.

    2013-01-01

    Chagas' disease, produced by Trypanosoma cruzi, affects more than 8 million people, producing approximately 10,000 deaths each year in Latin America. Migration of people from endemic regions to developed countries has expanded the risk of infection, transforming this disease into a globally emerging problem. PGE2 and other eicosanoids contribute to cardiac functional deficits after infection with T. cruzi. Thus, the inhibition of host cyclooxygenase (COX) enzyme emerges as a potential therapeutic target. In vivo studies about the effect of acetylsalicylic acid (ASA) upon T. cruzi infection are controversial, and always report the effect of ASA at a single dose. Therefore, we aimed to analyze the effect of ASA at different doses in an in vivo model of infection and correlate it with the production of arachidonic acid metabolites. ASA decreased mortality, parasitemia, and heart damage in T. cruzi (Dm28c) infected mice, at the low doses of 25 and 50 mg/Kg. However, this effect disappeared when the high ASA doses of 75 and 100 mg/Kg were used. We explored whether this observation was related to the metabolic shift toward the production of 5-lipoxygenase derivatives, and although we did not observe an increase in LTB4 production in infected RAW cells and mice infected, we did find an increase in 15-epi-LXA4 (an ASA-triggered lipoxin). We also found high levels of 15-epi-LXA4 in T. cruzi infected mice treated with the low doses of ASA, while the high ASA doses decreased 15-epi-LXA4 levels. Importantly, 15-epi-LXA4 prevented parasitemia, mortality, and cardiac changes in vivo and restored the protective role in the treatment with a high dose of ASA. This is the first report showing the production of ASA-triggered lipoxins in T. cruzi infected mice, which demonstrates the role of this lipid as an anti-inflammatory molecule in the acute phase of the disease. PMID:23638194

  12. Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon:the protective role of selenium

    Institute of Scientific and Technical Information of China (English)

    Abdel-Tawab Halim Mossa; Tarek Mohamed Heikal

    2014-01-01

    Objective:To investigate the adverse effect of exposure to acetylsalicylic acid (ASA), diazinon (DIA) and their combination on oxidant/antioxidant status in rat erythrocytes and the ameliorating role of selenium (Se). Methods: Rats were oral administered ASA at the maximum administration dose (1 350 mg/personal/d=2.5 mg/kg body weight/d), DIA at a dose of 20 mg/kg body weight/d and Se at a dose of 200 µg/kg body weight/d and their combinations for 28 consecutive d. Results: Administration of DIA, ASA and ASA+DIA lead to a significant increment (P≤0.05) in lipid peroxidation as evidenced by the increase in erythrocytes MDA levels by 61.8%, 20.79%and 105.62%, respectively. Co-administration of Se to treated rats modulated the augmentation of MDA levels. Administration of DIA, ASA and ASA+DIA lead to significant decreases (P≤0.05) in the activities of catalase, superoxide dismutase and glutathione peroxidase enzymes when compared to the control group. The most influence and decreases in the activities of the aforementioned enzymes were observed in the treatments of ASA+DIA by 30.53%, 43.42%and 48.31%, respectively. However, co-administration of Se mitigated the significant decreases of superoxide dismutase, catalase and glutathione peroxidase activities to by 14.47%, 15, 36%and 12.29%. Conclusions: It can be concluded that DIA and ASA induced oxidative stress and lipid peroxidation in rat erythrocytes. The results reveal the pronounced ameliorating effect of Se in DIA and ASA intoxicated rats. It is supposed that antioxidant supplementation may be beneficial for the people using ASA for longer periods and exposure to pesticides.

  13. Studies from the history of soil science and geology

    Science.gov (United States)

    Landa, Edward R.; Cohen, Benjamin R.

    2010-01-01

    The United Nations proclaimed the year 2008 as the official International Year of Planet Earth (IYPE), with science and outreach activities spanning 2007–2009. IYPE-sponsored outreach helped focus the attention of the general public on topics such as human health and the environment; ocean and natural resources sustainability; mitigating natural hazards and community resilience; and the effects of climate change. Within the earth science community, the IYPE was a stimulus for retrospection, and for efforts aimed at bridging divides within the community. One such effort was the first joint meeting of the Geological Society of America (GSA) and the Soil Science Society of America (SSSA), held in Houston, Texas, 5–9 October 2008.

  14. Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Cuffari C

    2016-02-01

    Full Text Available Carmen Cuffari,1 David Pierce,2 Bartosz Korczowski,3 Krzysztof Fyderek,4 Heather Van Heusen,5 Stuart Hossack,6 Hong Wan,5 Alena YZ Edwards,7 Patrick Martin5 1Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Shire, Basingstoke, UK; 3Medical College, University of Rzeszów, Rzeszów, Poland; 4University Children’s Hospital of Cracow, Cracow, Poland; 5Shire, Wayne, PA, USA; 6Covance Clinical Research Unit Limited, Leeds, UK; 7ICON Early Phase Services, Marlow, Buckinghamshire, UK Background: Limited data are available on mesalamine (5-aminosalicylic acid; 5-ASA use in pediatric ulcerative colitis (UC.Aim: To evaluate pharmacokinetic and safety profiles of 5-ASA and metabolite acetyl-5-ASA (Ac-5-ASA after once-daily, oral administration of multimatrix mesalamine to children and adolescents with UC.Methods: Participants (5–17 years of age; 18–82 kg, stratified by weight with UC received multimatrix mesalamine 30, 60, or 100 mg/kg/day once daily (to 4,800 mg/day for 7 days. Blood samples were collected pre-dose on days 5 and 6. On days 7 and 8, blood and urine samples were collected and safety was evaluated. 5-ASA and Ac-5-ASA plasma and urine concentrations were analyzed by non-compartmental methods and used to develop a population pharmacokinetic model.Results: Fifty-two subjects (21 [30 mg/kg]; 22 [60 mg/kg]; 9 [100 mg/kg] were randomized. On day 7, systemic exposures of 5-ASA and Ac-5-ASA exhibited a dose-proportional increase between 30 and 60 mg/kg/day cohorts. For 30, 60, and 100 mg/kg/day doses, mean percentages of 5-ASA absorbed were 29.4%, 27.0%, and 22.1%, respectively. Simulated steady-state exposures and variabilities for 5-ASA and Ac-5-ASA (coefficient of variation approximately 50% and 40%–45%, respectively were similar to those observed previously in adults at comparable doses. Treatment-emergent adverse events were

  15. Dicty_cDB: SSA662 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available putative transporter protein SSA662 (ssa662) mRNA, complete cds. 1267 0.0 4 AC115576 |AC115576.1 Dictyostel...SS (Link to library) SSA662 (Link to dictyBase) - G03081 DDB0185065 Contig-U07966-1 SSA...662P (Link to Original site) SSA662F 470 SSA662Z 664 SSA662P 1134 - - Show SSA662 Library SS (Link to library) Clone ID SSA...Contig-U07966-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA6-C/SSA...662Q.Seq.d/ Representative seq. ID SSA662P (Link to Original site) Representative DNA sequence >SSA662 (SSA662Q) /CSM/SS/SSA

  16. Dry Priming of Maize Seeds Reduces Aluminum Stress.

    Directory of Open Access Journals (Sweden)

    Berenice Kussumoto Alcântara

    Full Text Available Aluminum (Al toxicity is directly related to acidic soils and substantially limits maize yield. Earlier studies using hormones and other substances to treat the seeds of various crops have been carried out with the aim of inducing tolerance to abiotic stress, especially chilling, drought and salinity. However, more studies regarding the effects of seed treatments on the induction of Al tolerance are necessary. In this study, two independent experiments were performed to determine the effect of ascorbic acid (AsA seed treatment on the tolerance response of maize to acidic soil and Al stress. In the first experiment (greenhouse, the AsA seed treatment was tested in B73 (Al-sensitive genotype. This study demonstrates the potential of AsA for use as a pre-sowing seed treatment (seed priming because this metabolite increased root and shoot growth under acidic and Al stress conditions. In the second test, the evidence from field experiments using an Al-sensitive genotype (Mo17 and an Al-tolerant genotype (DA suggested that prior AsA seed treatment increased the growth of both genotypes. Enhanced productivity was observed for DA under Al stress after priming the seeds. Furthermore, the AsA treatment decreased the activity of oxidative stress-related enzymes in the DA genotype. In this study, remarkable effects using AsA seed treatment in maize were observed, demonstrating the potential future use of AsA in seed priming.

  17. IDENTIFICATION OF ACROSOME AS THE MAIN ANTIGEN OF THE SPERM CELLS PROVOKING AUTOANTIBODIES IN VASECTOMIZED IRANIAN MEN

    Directory of Open Access Journals (Sweden)

    M R Nowroozi

    2008-12-01

    Full Text Available "nVasectomy is one of the extensively used methods of contraception in family planning programs. Antisperm antibodies (ASA develop after vasectomy which can result in auto-immune male infertility. The precise sperm antigens involved in the autoimmune response are still poorly defined, therefore we determined the circulating ASA and identified relevant sperm antigens based on localization of binding sites of ASA to sperm cell antigens, using a rapid, inexpensive and clinically relevant assay in vasectomized men. Results showed that 2.5% of men had ASA at the time of vasectomy, whereas 53.5% of the study population subsequently developed ASA. The numbers of men with circulating ASA increased significantly for the first three months after vasectomy. These antibodies were distinguishable into three groups based on their bindings to different sites of sperm cell antigens including against acrosome and tail in 67.56% and 10.8%, respectively; 21.6% of subjects had antibody to the other parts of the sperm cell antigens. The results of this study are discussed in terms of an autoimmune response against sperm antigens and development of ASA.

  18. Deciphering ascorbic acid regulatory pathways in ripening tomato fruit using a weighted gene correlation network analysis approach.

    Science.gov (United States)

    Gao, Chao; Ju, Zheng; Li, Shan; Zuo, Jinhua; Fu, Daqi; Tian, Huiqin; Luo, Yunbo; Zhu, Benzhong

    2013-11-01

    Genotype is generally determined by the co-expression of diverse genes and multiple regulatory pathways in plants. Gene co-expression analysis combining with physiological trait data provides very important information about the gene function and regulatory mechanism. L-Ascorbic acid (AsA), which is an essential nutrient component for human health and plant metabolism, plays key roles in diverse biological processes such as cell cycle, cell expansion, stress resistance, hormone synthesis, and signaling. Here, we applied a weighted gene correlation network analysis approach based on gene expression values and AsA content data in ripening tomato (Solanum lycopersicum L.) fruit with different AsA content levels, which leads to identification of AsA relevant modules and vital genes in AsA regulatory pathways. Twenty-four modules were compartmentalized according to gene expression profiling. Among these modules, one negatively related module containing genes involved in redox processes and one positively related module enriched with genes involved in AsA biosynthetic and recycling pathways were further analyzed. The present work herein indicates that redox pathways as well as hormone-signal pathways are closely correlated with AsA accumulation in ripening tomato fruit, and allowed us to prioritize candidate genes for follow-up studies to dissect this interplay at the biochemical and molecular level.

  19. Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Jan Krejci

    2013-01-01

    Full Text Available Introduction. Nonpharmacological treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM comprises surgical myectomy (SME, alcohol septal ablation (ASA, and dual-chamber (DDD pacing. The aim of the study was to compare the long-term effect of DDD pacing and ASA in symptomatic HOCM patients. Patients and Methods. We evaluated retrospective data from three cardiocenters; there were 24 patients treated with DDD pacing included and 52 treated with ASA followed for 101 ± 49 and 87 ± 23 months, respectively. Results. In the group treated with DDD pacing, the left ventricle outflow tract gradient (LVOTG decreased from 82 ± 44 mmHg to 21 ± 21 mmHg, and NYHA class improved from 2.7 ± 0.5 to 2.1 ± 0.6 (both P<0.001. In the ASA-treated group, a decline in LVOTG from 73 ± 38 mmHg to 24 ± 26 mmHg and reduction in NYHA class from 2.8 ± 0.5 to 1.7 ± 0.8 were observed (both P<0.001. The LVOTG change was similar in both groups (P=0.264, and symptoms were more affected by ASA (P=0.001. Conclusion. ASA and DDD pacing were similarly effective in reducing LVOTG. The symptoms improvement was more expressed in patients treated with ASA.

  20. Deciphering Ascorbic Acid Regulatory Pathways in Ripening Tomato Fruit Using a Weighted Gene Correlation Network Analysis Approach

    Institute of Scientific and Technical Information of China (English)

    Chao Gao; Zheng Ju; Shan Li; Jinhua Zuo; Daqi Fu; Huiqin Tian; Yunbo Luo; Benzhong Zhu

    2013-01-01

    Genotype is generally determined by the co-expression of diverse genes and multiple regulatory pathways in plants. Gene co-expression analysis combining with physiological trait data provides very important information about the gene function and regulatory mechanism. L-Ascorbic acid (AsA), which is an essential nutrient component for human health and plant metabolism, plays key roles in diverse biological processes such as cell cycle, cell expansion, stress resistance, hormone synthesis, and signaling. Here, we applied a weighted gene correlation network analysis approach based on gene expression values and AsA content data in ripening tomato (Solanum lycopersicum L.) fruit with different AsA content levels, which leads to identification of AsA relevant modules and vital genes in AsA regulatory pathways. Twenty-four modules were compartmentalized according to gene expression profiling. Among these modules, one negatively related module containing genes involved in redox processes and one positively related module enriched with genes involved in AsA biosynthetic and recycling pathways were further analyzed. The present work herein indicates that redox pathways as well as hormone-signal pathways are closely correlated with AsA accumulation in ripening tomato fruit, and allowed us to prioritize candidate genes for follow-up studies to dissect this interplay at the biochemical and molecular level.

  1. Influence of cellulose powder structure on moisture-induced degradation of acetylsalicylic acid.

    Science.gov (United States)

    Mihranyan, A; Strømme, M; Ek, R

    2006-02-01

    The stability of crystalline acetylsalicylic acid (ASA) powder in binary mixtures with cellulose powders was investigated to reveal information about the influence of the cellulose structural properties on the moisture-induced ASA degradation. Different cellulose powder samples were manufactured and characterized by X-ray diffraction and N2 BET gas adsorption. The degradation patterns in ASA/cellulose mixtures were monitored as a function of salicylic acid increase versus time under various relative humidity conditions at 50 degrees C. The crystallinity index of cellulose samples varied between approximately 49 and 95%. The results indicated that cellulose powder with the lowest crystallinity index exhibited lower degradation rates than the samples with the higher crystallinity index. It should be noted that higher ASA degradation rates were observed in the samples with comparably lower moisture contents. This effect was most pronounced in the 1:3 (w/w), ASA/cellulose mixtures, whereas in 3:1 (w/w), ASA/cellulose mixtures the effect was less obvious. The findings emphasise the importance of cellulose structural organisation when governing the moisture's partition between cellulose and ASA during the hydrolytic degradation. PMID:16311024

  2. Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke.

    Directory of Open Access Journals (Sweden)

    Bing Chun Yan

    Full Text Available Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA, decursinol (DA and new synthetic aspirin-decursinol adduct (ASA-DA against transient focal and global cerebral ischemic damage. We found that treatment with 20 mg/kg, not 10 mg/kg, ASA-DA protected against ischemia-induced neuronal death after transient focal and global ischemic damage, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants levels in the corresponding injury regions. In brief, ASA-DA, a new synthetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.

  3. Effects of X‑ray irradiation in combination with ascorbic acid on tumor control.

    Science.gov (United States)

    Hosokawa, Yoichiro; Monzen, Satoru; Yoshino, Hironori; Terashima, Shingo; Nakano, Manabu; Toshima, Keisuke; Saga, Ryo; Kashiwakura, Ikuo

    2015-10-01

    Our previous studies demonstrated that the combination of treatment with ascorbic acid (AsA) and X‑ray irradiation results in increased apoptosis in HL60 cells. The present study was performed to investigate the effects of the combined use of AsA and X‑ray irradiation on epithelial cancer and sarcoma cells, and its potential use in future clinical treatment. X‑ray irradiation combined with AsA treatment resulted in increased suppression of cell growth of HT1080, SAS and A549 cells in vitro compared with X‑ray irradiation alone. The combined treatment also suppressed tumor growth in implanted HT‑1080 cells in vivo. Using annexin V/propidium iodide staining and the detection of activated caspase 3, it was found that X‑ray irradiation increased the apoptotic rate of HT1080 cells and resulted in G2/M arrest. However, apoptosis in the HT1080 cells treated with 5 mM AsA remained unchanged, and no changes were observed in the G2/M fraction. By contrast, AsA treatment caused increased suppression of proliferation compared with X‑ray irradiation. These results suggested that 5 mM AsA slowed the cell cycle and reduced tumor growth. Therefore, X‑ray irradiation combined with AsA treatment may be effective against epithelial cancer and sarcoma cells. PMID:26238154

  4. Asperosaponin VI promotes bone marrow stromal cell osteogenic differentiation through the PI3K/AKT signaling pathway in an osteoporosis model

    Science.gov (United States)

    Ke, Ke; Li, Qi; Yang, Xiaofeng; Xie, Zhijian; Wang, Yu; Shi, Jue; Chi, Linfeng; Xu, Weijian; Hu, Lingling; Shi, Huali

    2016-01-01

    Asperosaponin VI (ASA VI), a natural compound isolated from the well-known traditional Chinese herb Radix Dipsaci, has an important role in promoting osteoblast formation. However, its effects on osteoblasts in the context of osteoporosis is unknown. This study aimed to investigate the effects and mechanism of ASA VI action on the proliferation and osteogenic differentiation of bone marrow stromal cells isolated from the ovariectomized rats (OVX rBMSCs). The toxicity of ASA VI and its effects on the proliferation of OVX rBMSCs were measured using a CCK-8 assay. Various osteogenic differentiation markers were also analyzed, such as ALP activity, calcified nodule formation, and the expression of osteogenic genes, i.e., ALP, OCN, COL 1 and RUNX2. The results indicated that ASA VI promoted the proliferation of OVX rBMSCs and enhanced ALP activity and calcified nodule formation. In addition, while ASA VI enhanced the expression of ALP, OCN, Col 1 and RUNX2, treatment with LY294002 reduced all of these osteogenic effects and reduced the p-AKT levels induced by ASA VI. These results suggest that ASA VI promotes the osteogenic differentiation of OVX rBMSCs by acting on the phosphatidylinositol—3 kinase/AKT signaling pathway. PMID:27756897

  5. Long-distance transport of L-ascorbic acid in potato

    OpenAIRE

    Alberino Salvatore; Hancock Robert D; Tedone Luigi; Haupt Sophie; Viola Roberto

    2004-01-01

    Abstract Background Following on from recent advances in plant AsA biosynthesis there is increasing interest in elucidating the factors contributing to the L-ascorbic acid (AsA) content of edible crops. One main objective is to establish whether in sink organs such as fruits and tubers, AsA is synthesised in situ from imported photoassimilates or synthesised in source tissues and translocated via the phloem. In the current work we test the hypothesis that long-distance transport is involved i...

  6. Lack of Pharmacokinetic Interaction between Aspirin and Warfarin.

    Science.gov (United States)

    Fiske, William D.; Connell, Jill M.; Benedek, Irma H.

    1995-06-01

    An open-label, randomized, two-phase crossover study was conducted on 36 healthy male volunteers to identify the effects of coadministration of aspirin (acetylsalicylic acid; ASA) and crystalline warfarin sodium (Coumadin((R))) on the elimination and disposition kinetics of ASA, salicylic acid (SA) and R- and S-warfarin enantiomers. Twenty-four subjects were administered single doses of 325 mg of ASA alone and in combination with 10 mg of crystalline warfarin sodium with a 1-week washout between ASA doses. ASA and SA pharmacokinetic parameters were determined after each dose. Twelve subjects were administered single doses of 10 mg of crystalline warfarin sodium alone and in combination with 325 mg of ASA with a 4-week washout between warfarin doses. R- and S-warfarin enantiomer pharmacokinetic parameters were determined after each dose. Pharmacokinetic parameters were compared using analysis of variance and 90% confidence intervals. ASA and SA AUCs (the area under the plasma concentration versus time curve from time zero to time infinity) respectively were 3.28 plus minus 0.80 and 66.99 plus minus 11.73 &mgr;g h ml(minus sign1) (ASA alone), and 3.22 plus minus 0.61 and 69.48 plus minus 15.79 &mgr;g h ml(minus sign1) (ASA with warfarin). R-warfarin and S-warfarin AUCs respectively were 33.9 plus minus 9.3 and 23.9 plus minus 16.0 &mgr;g h ml(minus sign1) (warfarin alone) and 33.6 plus minus 10.2 and 22.6 plus minus 14.7 &mgr;g h ml(minus sign1) (warfarin with ASA). The only pharmacokinetic parameter which was statistically significantly different when the combination was administered was the S-warfarin elimination rate constant (p < 0.05), but the difference (9.2% increase in the presence of ASA) was small and no significant difference was found in S-warfarin clearance. It is concluded that there is no pharmacokinetic interaction when a single dose of ASA 325 mg is coadministered with a single dose of crystalline warfarin sodium 10 mg. PMID:11850685

  7. Assessment of the anterior spinal artery and the artery of Adamkiewicz using multi-detector CT angiography

    Institute of Scientific and Technical Information of China (English)

    ZHAO Shao-hong; Laura Logan; Pamela Schraedley; Geoffrey D. Rubin

    2009-01-01

    Background Damage to the spinal cord after the treatment of the descending thoracic and thoracoabdominal aortic aneurysms is an uncommon but devastating complication. The artery of Adamkiewicz (AKA) is the principal arterial supply of the anterior spinal artery (ASA) in the lower thoracic and lumbar level. The purpose of this study was to evaluate the visualization of the anterior spinal artery and the artery of Adamkiewicz, the affecting factors for the detection rate using multi-detector row CT (MDCT). Methods Ninety-nine consecutive patients (31 women and 68 men; age range, 25-90 years; average age 61.3 years), with suspicion for thoracic aortic lesions necessitating surgical intervention (31 aortic aneurysm, 45 dissection, 5 intramural hematoma, and 18 normal), underwent CT angiography from the aortic arch to the aortic bifurcation. Transverse sections, multiplanar reformations and thin maximum intensity projections were used to assess the ASA and AKA. The level of the ASA and AKA origins and CT acquisition parameters were recorded. The contrast-to-noise ratio of the image, an index of the mass of the T11 body (vertebral mass index), the subcutaneous fat thickness, and the CT value within the aortic arch and at the T11 level were measured. The detection of the ASA and AKA were evaluated relative to the acquisition parameters, scan characteristics, and aortic lesion type. Differences were assessed with the Wilcoxon rank-sum and t tests. Results The ASA was visualized in 51 patients (52%) and the AKA in 18 patients (18%). The ASA was identified in 36/67 patients (54%) with 1.25 mm thickness and in 15/32 patients (47%) with 2.5-3.0 mm thickness. This difference did not achieve significance (P=0.13). The detection rate of the ASA and the AKA was influenced by the vertebral mass index and the contrast-to-noise ratio (P<0.05). The amount of subcutaneous fat affected the detection rate of the ASA (P <0.05) but not the AKA. In CT scans of ASA detection, the mean CT

  8. Multi-detector CT angiography for the assessment of anterior spinal artery and artery of Adamkiewicz patency in patients suspected of having thoracic aortic pathology

    Institute of Scientific and Technical Information of China (English)

    Shaohong ZHAO; Laura Logan; Pamela Schraedley; Geoffrey D.Rubin

    2006-01-01

    Objective To evaluate the visualization of the anterior spinal artery (ASA) and the artery of Adamkiewicz (AKA) as well as the affecting factors for the detection rate using multidetector row CT (MDCT). Methods Ninety-nine consecutive patients (31 women and 68 men; age range, 25-90 years; average age 61.3 years) with suspicion for thoracic aortic lesions necessitating surgical intervention (31 aortic aneurysm, 45 dissection, 5 intramural hematoma, and 18 normal), underwent 16-slice MDCT angiography from the aortic arch to the aortic bifurcation. Transverse sections, multiplanar reformations (MPR) and thin maximum intensity projections (MIP) were used to assess the ASA and AKA. The level of the ASA and AKA origins and CT acquisition parameters were recorded. The contrast-to-noise ratio (CNR) of the image, an index of the mass of the T11 body (vertebral mass index), the subcutaneous fat thickness,and the CT value within the aortic arch and at the T11 level were measured. The detection of the ASA and AKA was evaluated relative to the acquisition parameters, scan characteristics, and aortic lesion type. Differences were assessed with Wilcoxon rank-sum and t tests. Results The ASA was visualized in 51 patients (52%) and the AKA in 18 patients (18 %). The ASA was identified in 36/67 (54%)patients with 1.25 mm thickness and in15/32 (47%) patients with 2.5-3.0 mm thickness. This difference did not achieve significance (P=0.13). The detection rate of the ASA and the AKA was influenced by vertebral mass index and the CNR (P<0.05). The amount of subcutaneous fat affected the detection rate of the ASA (P<0.05) but not the AKA. In CT scans with ASA detection, the mean CT values in the aorta at the arch and at T11 were 360 and 358 HU, respectively; whereas in CT scans without ASA detection, the CT values in the aorta at the arch and at T11 were lower (297 and 317 HU, respectively; both P<0.05). Conclusion The ASA and AKA were less frequently detected in our cohorts than

  9. Metal-rich or misclassified? The case of four RR Lyrae stars

    CERN Document Server

    Molnár, L; Plachy, E; Szabó, R

    2016-01-01

    We analysed the light curve of four, apparently extremely metal-rich fundamental-mode RR Lyrae stars. We identified two stars, MT Tel and ASAS J091803-3022.6 as RRc (first-overtone) pulsators that were misclassified as RRab ones in the ASAS survey. In the case of the other two stars, V397 Gem and ASAS J075127-4136.3, we could not decide conclusively, as they are outliers in the period-Fourier-coefficient space from the loci of both classes, but their photometric metallicities also favour the RRc classification.

  10. A New Application of an ANFIS for the Shape Optimal Design of Electromagnetic Devices

    Directory of Open Access Journals (Sweden)

    N. Mohdeb

    2014-09-01

    Full Text Available This paper presents a new model based on simulated annealing algorithm (ASA and adaptive neuro-fuzzy inference system (ANFIS for shape optimization and its applications to electromagnetic devices. The proposed model uses ANFIS system to evaluate the electromagnetic performance of the device. Both the ANFIS and ASA method are applied to the design/optimization of the electromagnetic actuator. The results of the proposed approach are compared with other techniques such as: method of moving asymptotes, penalty method, augmented lagrangian genetic algorithm and simulated annealing method (SA. Among the algorithms, the proposed ANFIS-ASA approach significantly outperforms the other methods.

  11. Libraries in New York: MedlinePlus

    Science.gov (United States)

    ... 718-534-0775 http://www.asa.edu Brooklyn Public Library Central Library Central Administration Office Grand Army Plaza ... www.drum.amedd.army.mil/ Glens Falls Crandall Public Library 251 Glen Street Glens Falls, NY 12801 518- ...

  12. Pärnusse seitse uut erinäolist skulptuuri / Anu Saare

    Index Scriptorium Estoniae

    Saare, Anu, 1964-

    2003-01-01

    Rait Pärgi korraldatud 3. rahvusvahelised skulptuuripäevad "Pärnu - positiivne märk" Pärnus, osa võtavad eestlased, prantslane Serge Samyn, leedulane Kestutis Launauskas ja islandlane Asa Hauksdottir

  13. Pärnus algasid skulptuuripäevad

    Index Scriptorium Estoniae

    2003-01-01

    Materjaliks puu, dolomiit, metall, betoon. Osa võtavad Serge Samyn Prantsusmaalt, Kestutis Lanauskai Leedust, Asa Hauksdottir Islandist, Meeland Sepp, Toomas Kuusing, Toomas Altnurme ja Rait Pärg Eestist

  14. Associations between spondyloarthritis features and MRI findings

    DEFF Research Database (Denmark)

    Arnbak, Bodil; Jurik, Anne Grethe; Hørslev-Petersen, Kim;

    2015-01-01

    ASAS definition, was present in 217(21%) patients. Of those, 91(42%) had bone marrow oedema (BMO) at the minimum requirement according to ASAS (low BMO score). HLA-B27, peripheral arthritis, good response to NSAID, and preceding infection associated independently with SIJ MRI findings (OR range 1...... clinical features and MRI findings included in ASAS criteria, and 2) explore the associations between clinical features and MRI findings. METHODS: Patients aged 18-40 years with persistent LBP referred to an outpatient spine clinic were included. Information on clinical features (incl. HLA-B27 and CRP) and......OBJECTIVES: The Assessment of SpondyloArthritis international Society (ASAS) has previously published criteria for spondyloarthritis (SpA). The objectives in the current study were in a low back pain (LBP) cohort, including an unknown proportion of SpA patients, to: 1) estimate the prevalence of...

  15. Easy Access to Coumarin Derivatives Using Alumina Sulfuric Acid as an Efficient and Reusable Catalyst under Solvent-Free Conditions

    Directory of Open Access Journals (Sweden)

    Ali Amoozadeh

    2013-01-01

    Full Text Available A new and efficient condition for the use of alumina sulfuric acid (ASA as a heterogeneous catalyst in the Pechmann condensation reaction in solvent-free condition for the formation of coumarins has been reported.

  16. 76 FR 43719 - Notice of Inventory Completion: University of Colorado Museum, Boulder, CO

    Science.gov (United States)

    2011-07-21

    ... Colorado Museum, Boulder, CO. The human remains were removed from near Laguna, Cibola County, NM. This... removed from Maxson site number 121, a rock fall near Laguna, Cibola County, NM, by Asa Maxson,...

  17. Propofol for sedation during colonoscopy- A survey of a Cochrane review

    DEFF Research Database (Denmark)

    Høj, Anders Thorsmark

    2010-01-01

    The Cochrane collaboration metaanalysis of propofol use during colonoscopy found a faster patient recovery, higher patient satisfaction and unchanged complication rate compared to traditional sedatives. Patient groups consisted mostly of ASA I-II-patients, therefore the study is inconclusive...

  18. Sedation med propofol til koloskopi. Gennemgang af et Cochrane-review

    DEFF Research Database (Denmark)

    Høj, Anders Thorsmark; Vilmann, Peter

    2010-01-01

    The Cochrane collaboration metaanalysis of propofol use during colonoscopy found a faster patient recovery, higher patient satisfaction and unchanged complication rate compared to traditional sedatives. Patient groups consisted mostly of ASA I-II-patients, therefore the study is inconclusive...

  19. Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations.

    Science.gov (United States)

    Yiğit, Aydın; Yardım, Yavuz; Çelebi, Metin; Levent, Abdulkadir; Şentürk, Zühre

    2016-09-01

    A graphene-Nafion composite film was fabricated on the glassy carbon electrode (GR-NF/GCE), and used for simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electrochemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-wave adsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR, ASA and CAF, their electrochemical oxidation peaks appeared at +0.64, 1.04 and 1.44V, and good linear current responses were obtained with the detection limits of 18ngmL(-1) (1.2×10(-9)M), 11.7ngmL(-1) (6.5×10(-8)M) and 7.3ngmL(-1) (3.8×10(-8)M), respectively. Finally, the proposed electrochemical sensor was successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations. PMID:27343573

  20. A multicenter,double-blind, placebo-controlled, randomized, phase Ⅲ clinical study of etanercept in treatment of ankylosing spondylitis%依那西普治疗强直性脊柱炎的多中心、随机、双盲、安慰剂对照临床研究

    Institute of Scientific and Technical Information of China (English)

    黄烽; 吕良敬; 杨尊明; 张洁; 黄建林; 吴东海; 栗占国; 陈顺乐; 潘云峰; 马丽; 陈适

    2010-01-01

    Objective To evaluate the short-term efficacy and safety of etanercept treatment in Chinese patients with active ankylosing spondylitis ( AS ). Methods This was a 12-week multicenter,double-blind, placebo-controlled, randomized phase Ⅲ clinical study. The first part was a 6-week placebocontrolled period followed by a 6-week open-label period. The primary efficacy endpoint was the percentage of subjects achieving a 20% improvement in assessment in ankylosing spondylitis (ASAS) ( ASAS 20). The secondary efficacy endpoints were the percentage of patients achieving a 40% improvement in ASAS (ASAS 40), achieving a 50% improvement in ASAS( ASAS 50), achieving a 70% improvement in ASAS (ASAS 70), and ASAS 5/6 responses at all visits, and the improvement in subject global assessment,physician global assessment, nocturnal and total back pain, bath AS functional index ( BASFI ), bath AS disease activity index (BASDAI), spinal mobility, joint assessment and quality of life assessment. All subjects in the study were evaluated for safety. Results The primary endpoint, ASAS 20 at week 6, was achieved by 86. 5% (64/74) patients in the etanercept group compared to 29. 5% (23/78) patients in the placebo group(P <0. 001 ). As early as week 2, the percentages of patients achieving the ASAS 20 between the two groups were significantly different. Furthermore, the majority of secondary efficacy end points were also significantly improved. Most of adverse events (AE) were mild in nature, the commonest adverse events were elevated liver function levels, injection site reactions and nasopharyngitis. No death or serious AE were observed. Conclusion Etanercept can improve symptoms fastly,significantly and safely in Chinese patients with active AS.%目的 评价依那西普治疗活动性强直性脊柱炎(AS)的短期疗效与安全性.方法 为期12周(双盲治疗期和开放治疗期各6周)的随机、双盲、安慰剂对照的Ⅲ期临床研究.双盲期试验组和对照组患

  1. Intra-cardiac echocardiography in alcohol septal ablation

    DEFF Research Database (Denmark)

    Cooper, Robert M; Shahzad, Adeel; Newton, James;

    2015-01-01

    Alcohol septal ablation (ASA) in hypertrophic obstructive cardiomyopathy reduces left ventricular outflow tract gradients. A third of patients do not respond; inaccurate localisation of the iatrogenic infarct can be responsible. Transthoracic echocardiography (TTE) using myocardial contrast can...

  2. American Sleep Association

    Science.gov (United States)

    ... Public Health Professionals Join ASA Press Room American Sleep Association Improving public health by increasing awareness about ... Members Username or Email Password Remember Me Register Sleep Blog Let’s Teach Our Children About Sleep How ...

  3. Abandoned Shipwreck Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Abandoned Shipwreck Act of 1987 (ASA) affirms the authority of state governments to claim ownership to, protect, and manage abandoned shipwrecks on state...

  4. Predicting Aggression among Male Adolescents: an Application of the Theory of Planned Behavior

    OpenAIRE

    ZinatMotlagh, Fazel; Ataee, Mari; Jalilian, Farzad; MirzaeiAlavijeh, Mehdi; Aghaei, Abbas; Karimzadeh Shirazi, Kambiz

    2013-01-01

    Background: Aggressive behaviorin adolescencecan be expressed asa predictorfor crime, substanceabuse, depression and academic failure. The purpose of this study was to determine the prediction of aggression among Iranian adolescent based on theory of planned behavior (TPB) as a theoretical framework.

  5. Täna kell 20 esitletakse EKA galerii...

    Index Scriptorium Estoniae

    2004-01-01

    Esitletakse norra kunstnike (loetletud) videosid "Darling, don't leave me all by myself". Korraldaja Bergeni kuraatoriduo Rakett (Asa Lövgren, Karolin Tampere). 4. IV näeb Tallinna projekti Von Krahli teatris

  6. Demonstration of the analgesic efficacy and dose-response of acetylsalicylic acid with pseudoephedrine.

    Science.gov (United States)

    Schachtel, Bernard P; Voelker, Michael; Sanner, Kathleen M; Gagney, Diana; Bey, Mary; Schachtel, Emily J; Becka, Michael

    2010-12-01

    To determine acute analgesia by acetylsalicylic acid (ASA) when combined with pseudoephedrine (PSE) in patients with upper respiratory tract infection (URTI), we used the sore throat pain model to measure single-dose effects of ASA 500 mg/PSE 30 mg, ASA 1000 mg/PSE 60 mg, and acetaminophen (APAP) 1000 mg/PSE 60 mg (serving as a positive control). Under double-blind, randomized, placebo-controlled conditions, 640 adult patients with confirmed acute pharyngitis and rhinosinusitis associated with URTI rated throat pain intensity and relief at intervals over 6 hours. Efficacy was demonstrated for both doses of ASA/PSE compared with placebo for all end points, including total pain relief and summed pain intensity differences, beginning at 20 minutes on both scales (all P pseudoephedrine.

  7. Võidufilm on happy / Johan Palmgren ; interv. Tiit Tuumalu

    Index Scriptorium Estoniae

    Palmgren, Johan

    2004-01-01

    Lõppes Pärnu 18. dokumentaal- ja antropoloogiafilmide festival - võitjaks tuli noorte rootslaste Johan Palmgreni ja Asa Blanchi film "Ebba ja Torgny ehk Armastuse imelised teed". Lisaks "Pärnu festivali auhindu"

  8. Ship Traffic 2011 West Coast Region - All Ship Types

    Data.gov (United States)

    Bureau of Ocean Energy Management, Department of the Interior — The data was derived from US Coast Guard raw vessel point returns and preprocessed by ASA (Applied Science Associates), to one minute point interCAls. The data...

  9. Consistent Blood Pressure Control May Cut Rate of Second Stroke in Half

    Science.gov (United States)

    ... AHA/ASA Embargoed Media Materials Media Contacts Boilerplate Branding Guidelines Copyright Permissions Embargo/Recording Policies Linking Policy ... associate chief medical officer at Rancho Los Amigos National Rehabilitation Center in Downey, Calif. Reducing salt intake, ...

  10. Investigation of an angular spectrum approach for pulsed ultrasound fields

    DEFF Research Database (Denmark)

    Du, Yigang; Jensen, Henrik; Jensen, Jørgen Arendt

    2013-01-01

    An Angular Spectrum Approach (ASA)is formulated and employed to simulate linear pulsed ultra sound fields for high bandwidth signals. Ageometrically focused piston transducer is used as the acoustic source. Signals are cross-correlated to findthe true sound speed during the measurement to make...... the simulated and measured pulses in phase for comparisons. The calculated sound speed in the measurement is varied between 1487.45 m/s and 1487.75 m/s by using different initial values in the ASA simulation. Results from the pulsed ASA simulation susing both Field II simulated and hydrophone measured acoustic...... sources are compared to the Field II simulated and hydroph one measure dpulses, respectively. The total relative root mean squar e(RMS)errors of the pulsed ASA are investigated by using different time-point, zero-padding factors, spatial sampling interval and temporal sampling frequency in the sim ulation...

  11. Angular spectrum approach for fast simulation of pulsed non-linear ultrasound fields

    DEFF Research Database (Denmark)

    Du, Yigang; Jensen, Henrik; Jensen, Jørgen Arendt

    2011-01-01

    The paper presents an Angular Spectrum Approach (ASA) for simulating pulsed non-linear ultrasound fields. The source of the ASA is generated by Field II, which can simulate array transducers of any arbitrary geometry and focusing. The non-linear ultrasound simulation program - Abersim, is used...... as the reference. A linear array transducer with 64 active elements is simulated by both Field II and Abersim. The excitation is a 2-cycle sine wave with a frequency of 5 MHz. The second harmonic field in the time domain is simulated using ASA. Pulse inversion is used in the Abersim simulation to remove...... the fundamental and keep the second harmonic field, since Abersim simulates non-linear fields with all harmonic components. ASA and Abersim are compared for the pulsed fundamental and second harmonic fields in the time domain at depths of 30 mm, 40 mm (focal depth) and 60 mm. Full widths at -6 dB (FWHM) are f0...

  12. The effect of low-dose acetylsalicylic acid on bleeding after transurethral prostatectomy--a prospective, randomized, double-blind, placebo-controlled study

    DEFF Research Database (Denmark)

    Nielsen, Jesper Dan; Holm-Nielsen, A; Jespersen, J;

    2000-01-01

    OBJECTIVE: An increase in the loss of blood after ingestion of acetylsalicylic acid (ASA) has been reported after several types of surgery, but randomized placebo-controlled studies have exclusively been performed after coronary artery bypass surgery. The reported effects of ASA on bleeding after...... transurethral prostatectomy (TURP) have been conflicting. We have studied the effect of low doses of ASA (150 mg) on bleeding after TURP in a prospective, randomized, double-blind, placebo-controlled trial. PATIENTS AND METHODS: Patients were randomized to receive either 150 mg ASA (n = 26) or placebo (n = 27...... group (median 284; quartiles 196-660 ml) was significantly higher than in the placebo group (median 144; quartiles 75-379 ml), (p = 0.011). No significant difference was observed between the groups regarding the amount of resected tissue (p = 0.209) or the operating time (p = 0.297). In both groups the...

  13. Aeromonas salmonicida subsp. salmonicida strains isolated from Chinese freshwater fish contain a novel genomic island and possible regional-specific mobile genetic elements profiles

    DEFF Research Database (Denmark)

    Long, Meng; Nielsen, Tue K; Leisner, Jørgen J;

    2016-01-01

    variant of the genomic island AsaGEI in BG, designated as AsaGEI2c This is the first report on a GEI of A. salmonicida strain from China. Furthermore, both YK and BG strains contained a Tn7 transposon inserted at the same position in the chromosome. Finally, IS-dependent rearrangements on pAsa5 are deemed...... likely to have occurred, with omission of the resD gene in both strains as well as omission of genes related to the IncF conjugal transfer system in the YK isolate. This study demonstrates that A. salmonicida subsp. salmonicida can infect non-salmonids (cyprinids) in addition to salmonids, and that Asa...... of which belonged to the cyprinid family, and the strains showed a difference in virulence. Subsequently, we performed whole genome sequencing of the strains, and comparison of their genomic sequences to the genome of the A449 reference strain revealed various genomic rearrangements, including a new...

  14. Ascorbate biosynthesis during early fruit development is the main reason for its accumulation in kiwi.

    Directory of Open Access Journals (Sweden)

    Mingjun Li

    Full Text Available BACKGROUND: Ascorbic acid (AsA is a unique antioxidant as well as an enzyme cofactor. Although it has multiple roles in plants, it is unclear how its accumulation is controlled at the expression level, especially in sink tissues. Kiwifruit (Actinidia is well-known for its high ascorbate content. Our objective was to determine whether AsA accumulates in the fruits primarily through biosynthesis or because it is imported from the foliage. METHODOLOGY/PRINCIPAL FINDINGS: We systematically investigated AsA levels, biosynthetic capacity, and mRNA expression of genes involved in AsA biosynthesis in kiwi (A. deliciosa cv. Qinmei. Recycling and AsA localization were also monitored during fruit development and among different tissue types. Over time, the amount of AsA, with its capacity for higher biosynthesis and lower recycling, peaked at 30 days after anthesis (DAA, and then decreased markedly up to 60 DAA before declining more slowly. Expression of key genes showed similar patterns of change, except for L-galactono-1,4-lactone dehydrogenase and L-galactose-1-phosphate phosphatase (GPP. However, GPP had good correlation with the rate of AsA accumulation. The expression of these genes could be detected in phloem of stem as well as petiole of leaf and fruit. Additionally, fruit petioles had greater ascorbate amounts, although that was the site of lowest expression by most genes. Fruit microtubule tissues also had higher AsA. However, exogenous applications of AsA to those petioles did not lead to its transport into fruits, and distribution of ascorbate was cell-specific in the fruits, with more accumulation occurring in larger cells. CONCLUSIONS: These results suggest that AsA biosynthesis in kiwi during early fruit development is the main reason for its accumulation in the fruits. We also postulate here that GPP is a good candidate for regulating AsA biosynthesis whereas GDP-L-galactose-1-phosphate phosphorylase is not.

  15. A Performance Assessment of an Airborne Separation Assistance System Using Realistic Complex Traffic Flows

    Science.gov (United States)

    Smith, Jeremy C.; Bussink, Frank J. L.

    2008-01-01

    This paper presents the results from a study that investigates the performance of a tactical Airborne Separation Assistance System (ASAS) in en route airspace, under varying demand levels, with realistic traffic flows. The ASAS concept studied here allows flight crews of equipped aircraft to perform separation from other air traffic autonomously. This study addresses the tactical aspects of an ASAS using aircraft state data (i.e. position and velocity) to detect and resolve projected conflicts. In addition, use of a conflict prevention system helps ASAS-equipped aircraft avoid maneuvers that may cause new conflicts. ASAS-capable aircraft are equipped with satellite-based navigation and Automatic Dependent Surveillance Broadcast (ADS-B) for transmission and receipt of aircraft state data. In addition to tactical conflict detection and resolution (CD&R), a complete, integrated ASAS is likely to incorporate a strategic CD&R component with a longer look-ahead time, using trajectory intent information. A system-wide traffic flow management (TFM) component, located at the FAA command center helps aircraft to avoid regions of excessive traffic density and complexity. A Traffic Alert and Collision Avoidance System (TCAS), as used today is the system of last resort. This integrated approach avoids sole reliance on the use of the tactical CD&R studied here, but the tactical component remains a critical element of the complete ASAS. The focus of this paper is to determine to what extent the proposed tactical component of ASAS alone can maintain aircraft separation at demand levels up to three times that of current traffic. The study also investigates the effect of mixing ASAS-equipped aircraft with unequipped aircraft (i.e. current day) that do not have the capability to self-separate. Position and velocity data for unequipped aircraft needs to be available to ASASequipped. Most likely, for this future concept, state data would be available from instrument flight rules (IFR

  16. Rice GDP-mannose pyrophosphorylase OsVTC1-1 and OsVTC1-3 play different roles in ascorbic acid synthesis.

    Science.gov (United States)

    Qin, Hua; Deng, Zaian; Zhang, Chuanyu; Wang, Yayun; Wang, Juan; Liu, Hai; Zhang, Zhili; Huang, Rongfeng; Zhang, Zhijin

    2016-02-01

    GDP-D-mannose pyrophosphorylase (GMPase) catalyzes the synthesis of GDP-D-mannose, which is a precursor for ascorbic acid (AsA) synthesis in plants. The rice genome encodes three GMPase homologs OsVTC1-1, OsVTC1-3 and OsVTC1-8, but their roles in AsA synthesis are unclear. The overexpression of OsVTC1-1 or OsVTC1-3 restored the AsA synthesis of vtc1-1 in Arabidopsis, while that of OsVTC1-8 did not, indicating that only OsVTC1-1 and OsVTC1-3 are involved in AsA synthesis in rice. Similar to Arabidopsis VTC1, the expression of OsVTC1-1 was high in leaves, induced by light, and inhibited by dark. Unlike OsVTC1-1, the expression level of OsVTC1-3 was high in roots and quickly induced by the dark, while the transcription level of OsVTC1-8 did not show obvious changes under constant light or dark treatments. In OsVTC1-1 RNAi plants, the AsA content of rice leaves decreased, and the AsA production induced by light was limited. In contrast, OsVTC1-3 RNAi lines altered AsA synthesis levels in rice roots, but not in the leaves or under the light/dark treatment. The enzyme activity showed that OsVTC1-1 and OsVTC1-3 had higher GMPase activities than OsVTC1-8 in vitro. Our data showed that, unlike in Arabidopsis, the rice GPMase homologous proteins illustrated a new model in AsA synthesis: OsVTC1-1 may be involved in the AsA synthesis, which takes place in leaves, while OsVTC1-3 may be responsible for AsA synthesis in roots. The different roles of rice GMPase homologous proteins in AsA synthesis may be due to their differences in transcript levels and enzyme activities.

  17. Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers

    Directory of Open Access Journals (Sweden)

    Nagelschmitz J

    2014-03-01

    Full Text Available J Nagelschmitz,1 M Blunck,1 J Kraetzschmar,1 M Ludwig,1 G Wensing,1 T Hohlfeld2 1Bayer HealthCare AG, Clinical Pharmacology, Wuppertal, Germany; 2Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany Background: The pharmacology of single doses of acetylsalicylic acid (ASA administered intravenously (250 or 500 mg or orally (100, 300, or 500 mg was evaluated in a randomized, placebo-controlled, crossover study. Methods: Blood and urine samples were collected before and up to 24 hours after administration of ASA in 22 healthy volunteers. Pharmacokinetic parameters and measurements of platelet aggregation were determined using validated techniques. Results: A comparison between administration routes showed that the geometric mean dose-corrected peak concentrations (Cmax/D and the geometric mean dose-corrected area under the curve (AUC0–∞/D were higher following intravenous administration of ASA 500 mg compared with oral administration (estimated ratios were 11.23 and 2.03, respectively. Complete inhibition of platelet aggregation was achieved within 5 minutes with both intravenous ASA doses, reflecting a rapid onset of inhibition that was not observed with oral dosing. At 5 minutes after administration, the mean reduction in arachidonic acid-induced thromboxane B2 synthesis ex vivo was 99.3% with ASA 250 mg intravenously and 99.7% with ASA 500 mg intravenously. In exploratory analyses, thromboxane B2 synthesis was significantly lower after intravenous versus oral ASA 500 mg (P<0.0001 at each observed time point up to the first hour after administration. Concentrations of 6-keto-prostaglandin1α at 5 and 20 minutes after dosing were also significantly lower with ASA 500 mg intravenously than with ASA 500 mg orally. Conclusion: This study demonstrates that intravenous ASA provides more rapid and consistent platelet inhibition than oral ASA within the first hour after dosing

  18. Radiation protection with mesalamine (5-amino salicylic acid)

    International Nuclear Information System (INIS)

    Purpose: Radiation proctitis induced during the therapy of rectal and prostate cancers, and radiation injuries in general, are often the principal dose limiting factor limiting dose escalation for radiation therapy. Thus, there has been a continuous search for radioprotective agents, especially those that could selectively protect normal tissues, as opposed to the target cancer. 5-amino salicylic acid (5ASA) is in clinical use as Mesalamine for the local treatment of ulcerative proctitis. Inasmuch as other investigators have identified 5ASA as a free radical scavenger, we determined whether pretreatment with 5ASA could confer radiation protection. Materials and Methods: Adult male C57BL/6J mice obtained from Jackson Laboratories were employed for these studies. We determined LD50 for acute gastrointestinal death for young (≤ 10 weeks old, ≤ 25 gms body weight) and aged (≥ 1 year old, ≥ 35 gms body weight) animals exposed to single fractions (1 - 20 Gy) from three different radiation sources, Cs137, 270 KeV x-rays, and a 4 MeV linear accelerator. Experimental mice were pre- or post-treated with 5ASA in an acidified isotonic saline solution by oral, rectal, or intraperitoneal administration. Animals were housed, maintained by AAALAC standards and treated with antibiotics or acidified water post radiation exposure to control opportunistic infections. Animals were scored for death when moribund. Results: 5ASA was found to be radioprotective by oral, rectal or intraperitoneal administration when given 15 to 90 minutes prior to radiation exposure. Administration of drug following radiation exposure failed to confer radioprotection. We determined a dose effect for 5ASA with maximum tolerated dose of 200 mg/kg administered ip 30 minutes prior to 11 Gy whole body exposure. Dose modification and radioprotection by 5ASA were determined by LD50(6), LD50(30), or LD50(365). More recently, we determined that 5ASA conferred significant radioprotection to mice exposed to

  19. Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xianwei, E-mail: XWang2@UAMS.edu; Lu, Jingjun; Khaidakov, Magomed; Mitra, Sona; Ding, Zufeng; Raina, Sameer; Goyal, Tanu; Mehta, Jawahar L., E-mail: MehtaJL@UAMS.edu

    2012-03-15

    Aspirin (acetyl salicylic acid, ASA) is a common drug used for its analgesic and antipyretic effects. Recent studies show that ASA not only blocks cyclooxygenase, but also inhibits NADPH oxidase and resultant reactive oxygen species (ROS) generation, a pathway that underlies pathogenesis of several ailments, including hypertension and tissue remodeling after injury. In these disease states, angiotensin II (Ang II) activates NADPH oxidase via its type 1 receptor (AT1R) and leads to fibroblast growth and collagen synthesis. In this study, we examined if ASA would inhibit NADPH oxidase activation, upregulation of AT1R transcription, and subsequent collagen generation in mouse cardiac fibroblasts challenged with Ang II. Mouse heart fibroblasts were isolated and treated with Ang II with or without ASA. As expected, Ang II induced AT1R expression, and stimulated cardiac fibroblast growth and collagen synthesis. The AT1R blocker losartan attenuated these effects of Ang II. Similarly to losartan, ASA, and its SA moiety suppressed Ang II-mediated AT1R transcription and fibroblast proliferation as well as expression of collagens and MMPs. ASA also suppressed the expression of NADPH oxidase subunits (p22{sup phox}, p47{sup phox}, p67{sup phox}, NOX2 and NOX4) and ROS generation. ASA did not affect total NF-κB p65, but inhibited its phosphorylation and activation. These observations suggest that ASA inhibits Ang II-induced NADPH oxidase expression, NF-κB activation and AT1R transcription in cardiac fibroblasts, and fibroblast proliferation and collagen expression. The critical role of NADPH oxidase activity in stimulation of AT1R transcription became apparent in experiments where ASA also inhibited AT1R transcription in cardiac fibroblasts challenged with H{sub 2}O{sub 2}. Since SA had similar effect as ASA on AT1R expression, we suggest that ASA's effect is mediated by its SA moiety. -- Highlights: ► Aspirin in therapeutic concentrations decreases mouse cardiac

  20. Use of Aspirin Associates with Longer Primary Patency of Hemodialysis Grafts

    OpenAIRE

    Dixon, Bradley S.; Beck, Gerald J.; Dember, Laura M; Vazquez, Miguel A.; Greenberg,Arthur; Delmez, James A.; Allon, Michael; Himmelfarb, Jonathan; Hu, Bo; Greene, Tom; Radeva, Milena K.; Davidson, Ingemar J.; Ikizler, T. Alp; Braden, Gregory L.; Lawson, Jeffrey H.

    2011-01-01

    Extended-release dipyridamole plus low-dose aspirin (ERDP/ASA) prolongs primary unassisted graft patency of newly created hemodialysis arteriovenous grafts, but the individual contributions of each component are unknown. Here, we analyzed whether use of aspirin at baseline associated with primary unassisted graft patency among participants in a randomized trial that compared ERDP/ASA and placebo in newly created grafts. We used Cox proportional hazards regression, adjusting for prespecified b...

  1. Prevalence of Child and Adult Sexual Abuse and Risk Taking Practices Among HIV Serodiscordant African-American Couples

    OpenAIRE

    el-Bassel, N; Wingood, G; Wyatt, GE; III, JJB; Pequegnat, W; Landis, JR; Bellamy, S.; Gilbert, L; Remien, RH; Witte, S; Wu, E; DiClemente, R; Myers, H.; Jemmott, LS; Metzger, D

    2010-01-01

    This study reports the prevalence of child (CSA) and adult (ASA) sexual abuse among 535 African American HIV serodiscordant couples from four major United State cities, and its relationship to personal and couple related vulnerabilities and HIV risk factors. As part of a randomized, clinical trial, CSA and ASA histories were obtained through face-to-face interviews. Results indicate that HIV positive women were significantly more likely to report one kind of abuse (32.32%), either before or s...

  2. Sociology and Classical Liberalism

    OpenAIRE

    KLEIN, Daniel; Stern, Lotta

    2005-01-01

    We advocate the development of a classical-liberal character within professional sociology. The American Sociological Association (ASA) is taken as representative of professional sociology in the United States. We review the ASA’s activities and organizational statements, to show the association’s leftist character. Internal criticism is often very uneasy about leftist domination of the field. We present survey results establishing that, in voting and in policy views, the ASA membership is mo...

  3. Control of cucumber (Cucumis sativus L. tolerance to chilling stress – evaluating the role of ascorbic acid and glutathione

    Directory of Open Access Journals (Sweden)

    Alexander S. Lukatkin

    2014-12-01

    Full Text Available Chilling temperatures (1-10 ºC are known to disturb cellular physiology, cause oxidative stress via creating imbalance between generation and metabolism of reactive oxygen species (ROS leading finally to cell and/or plant death. Owing to known significance of low molecular antioxidants - ascorbic acid (AsA and glutathione (GSH in plant stress-tolerance, this work analyzes the role of exogenously applied AsA and GSH in the alleviation of chilling stress (3°C-impact in cucumber (Cucumis sativus L. cv. Vjaznikowskij 37 plants. Results revealed AsA and GSH concentration dependent metabolism of ROS such as superoxide (O2•‾ and the mitigation of ROS-effects such as lipid peroxidation (LPO as well as membrane permeability (measured as electrolyte leakage in C. sativus leaf discs. AsA concentration (750 µM and GSH (100 µM exhibited maximum reduction in O2•‾ generation, LPO intensity as well as electrolyte leakage, all of these were increased in cold water (3°C and 25°C-treated leaf discs. However, AsA, in particular, had a pronounced antioxidative effect, more expressed in case of leaf discs during chilling (3°C; whereas, at temperature 25°C, some AsA concentrations (such as 50 and 100 mM AsA exhibited a prooxidative effect that requires molecular-genetic studies. Overall, it is inferred that AsA and GSH have high potential for sustainably increasing chilling-resistance in plants.

  4. Bipolar Saline TURP for Large Prostate Glands

    OpenAIRE

    Finley, David S.; Shawn Beck; Szabo, Richard J.

    2007-01-01

    The objective of this study was to evaluate the feasibility of bipolar transurethral resection of the prostate ( TURP) in patients with very large prostate glands and significant comorbidities. Four patients with prostate glands > 160 cc on preoperative volume measurement and ASA class three or higher underwent bipolar TURP with the Gyrus PlasmaKinetic system. Preoperative, operative, and postoperative parameters were studied. The results showed an average ASA class 3.25 (range: 3-4). The ave...

  5. Characterization of fertility related antisperm antibodies-a step towards causal treatment of immunological infertility and immuno-contraception

    Institute of Scientific and Technical Information of China (English)

    Gerhard Haidl

    2010-01-01

    @@ Antisperm antibodies (ASA)occur in men and women and may significantly impair fertility. The identification of functionally rele-vant antigens of ASA is important for establishing causal treatment options on the one hand and may,on the other hand, enhance the de-velopment of tools for immunocon-traception. One candidate protein is addressed in an article of Wang et al. [1] published in Asian Journal of Andrology.

  6. 对存在其他特殊情况的卒中患者的治疗%Treatment for Stroke Patients with Special Circumstances

    Institute of Scientific and Technical Information of China (English)

    徐蔚海

    2011-01-01

    @@ 美国心脏协会(American Heart Association,AHA)/美国卒中协会(American Stroke Association,ASA)2011版缺血性卒中/短暂性脑缺血发作(TransientIschemic Attack,TIA)二级预防指南(ASA2011二级预防指南)第五部分对临床一些少见卒中类型的治疗做了阐述.

  7. A metabolomics strategy to explore urinary biomarkers and metabolic pathways for assessment of interaction between Danhong injection and low-dose aspirin during their synergistic treatment.

    Science.gov (United States)

    Li, Jianping; Guo, Jianming; Shang, Erxin; Zhu, Zhenhua; Zhu, Kevin Yue; Li, Shujiao; Zhao, Buchang; Jia, Lifu; Zhao, Jing; Tang, Zhishu; Duan, Jinao

    2016-07-15

    The drug combination of Danhong injection (DHI) and low-dose aspirin (ASA) was frequently applied for the treatment of cardiovascular and cerebrovascular diseases. Due to the drug interactions, a lot of potential benefits and risks might exist side by side in the course of combination therapy. However, there had been no studies of interaction between DHI and ASA. Metabolomics was a powerful tool to explore endogenous biomarkers and metabolic pathways. In present study, metabolic profiling with ultra-high-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UHPLC-QTOF/MS) coupled with multivariate statistical analysis was performed to provide insight into understanding the interaction between DHI and low-dose ASA. Eleven potential biomarkers of three types were identified and seven metabolic pathways were constructed. The results showed that the interaction between DHI and low-dose ASA during synergistic treatment indeed affected some key endogenous biomarkers and metabolic pathways, which could not happen when DHI or low-dose ASA was used alone. The quality and quantity of endogenous metabolite were both influenced by interaction between DHI and low-dose ASA. In details, the amount of flavin mononucleotide, L-2, 4-diaminobutyric acid (DABA) and 4-aminohippuric acid were significantly increased. On the contrary, the amount of 3-methyluridine, 4, 6-dihydroxyquinoline, cortolone-3-glucuronide, and serotonin were significantly decreased. Furthermore, O-phosphotyrosine, 3-methyl-2-butenal, indoxyl sulfate and dolichyl diphosphate were disappeared in urine. As to metabolic pathways, riboflavin metabolism, pentose and glucuronate interconversions, and tryptophan metabolism were all significantly influenced. The emerging alterations of biomarkers and metabolic pathways were associated with a lot of drugs and diseases based on literature researches, which might influence the co-administration of other drugs or the treatments of relevant

  8. Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT.

    Directory of Open Access Journals (Sweden)

    Thomas J Montine

    Full Text Available Results from prevention trials, including the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT, have fueled discussion about the cardiovascular (CV risks associated with non-steroidal anti-inflammatory drugs (NSAIDs. We tested the hypotheses that (i adverse CV events reported among ADAPT participants (aged 70 years and older are associated with increased ratio of urine 11-dehydrothromboxane B(2 (Tx-M to 2'3-donor-6-keto-PGF1 (PGI-M attributable to NSAID treatments; (ii coincident use of aspirin (ASA would attenuate NSAID-induced changes in Tx-M/PGI-M ratio; and (iii use of NSAIDs and/or ASA would not alter urine or plasma concentrations of F(2-isoprostanes (IsoPs, in vivo biomarkers of free radical damage. We quantified urine Tx-M and PGI-M, and urine and plasma F(2-IsoPs from 315 ADAPT participants using stable isotope dilution assays with gas chromatography/mass spectrometry, and analyzed these data by randomized drug assignment and self-report compliance as well as ASA use. Adverse CV events were significantly associated with higher urine Tx-M/PGI-M ratio, which seemed to derive mainly from lowered PGI-M. Participants taking ASA alone had reduced urine Tx-M/PGI-M compared to no ASA or NSAID; however, participants taking NSAIDs plus ASA did not have reduced urine Tx-M/PGI-M ratio compared to NSAIDs alone. Neither NSAID nor ASA use altered plasma or urine F(2-IsoPs. These data suggest a possible mechanism for the increased risk of CV events reported in ADAPT participants assigned to NSAIDs, and suggest that the changes in the Tx-M/PGI-M ratio was not substantively mitigated by coincident use of ASA in individuals 70 years or older.

  9. Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells

    Institute of Scientific and Technical Information of China (English)

    Siamak Bidel; Harri Mustonen; Giti Khalighi-Sikaroudi; Eero Lehtonen; Pauli Puolakkainen; Tuula Kiviluoto; Eero Kivilaakso

    2005-01-01

    AIM: To assess the effects of ulcerogenic agents on actin cytoskeleton and cell motility and the contribution of oxidative stress.METHODS: Rat gastric mucosal cell monolayers were cultured on coverslips. The cells were exposed, with or without allopurinol (2 mmol/L), for 15 min to ethanol (10-150 mL/L), ASA (1-20 mmol/L) or taurocholate (1-20 mmol/L), then the cells were processed for actin and vinculin staining. Cell migration after wounding was also measured.RESULTS: Exposure to 10 mL/L ethanol caused divergence of zonula adherens-associated actin bundles of adjacent cells and decreased rate of migration. These actions were opposed by xanthine oxidase inhibitor allopurinol. Exposure to 50 mL/L ethanol induced degradation and divergence of zonula adherens-associated vinculin from adjacent cells,which was, again, partially reverted by allopurinol. With 1 mmol/L ASA actin filaments became shorter and thicker.However, higher concentrations (10, 20 mmol/L) of ASA returned microfilaments thinner and longer, and decreased rate of migration. Zonula adherens-associated actin bundles were moderately distorted with 10 mmol/L ASA and with 10 mmol/L taurocholate. Exposure to taurocholate provoked changes resembling those of ASA. Taurocholate 5-20 mmol/L decreased the rate of migration dose dependently. The effects of ASA and taurocholate were not prevented by allopurinol.CONCLUSION: All ulcerogenic agents decreased the rate of migration dose dependently and induced divergence of zonula adherens-associated actin bundles of adjacent cells.In addition, ethanol and ASA caused degradation of actin cytoskeleton. Oxidative stress seems to underlie ethanol,but not ASA or taurocholate, induced cytoskeletal damage.

  10. Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro

    OpenAIRE

    Broekman, Mark M. T. J.; Roelofs, Hennie M. J.; Wong, Dennis R.; Kerstholt, Mariska; Leijten, Alex; Hoentjen, Frank; Peters, Wilbert H. M.; Geert J A Wanten; de Jong, Dirk J.

    2015-01-01

    Introduction The use of thiopurines is frequently accompanied by hepatotoxicity. Studies on hepatocyte cultures showed a time- and dose-dependent increase of thiopurine toxicity. 5-Aminosalicylic acid (5-ASA) and allopurinol can influence thiopurine metabolism; however, it is unknown whether this affects in vitro cytotoxicity. Methods Human hepatoma cells (Huh7, HepG2 and HepaRG) were incubated with increasing concentrations of thiopurines, 5-ASA or allopurinol. Water-soluble tetrazolium salt...

  11. Masking of Pressure Overload in a Patient with Pulmonary Thromboembolism Accompanied by Atrial Septal Aneurysm

    OpenAIRE

    Yu, Tae Kyung; Kim, Woo Shik; Kim, Weon

    2011-01-01

    A pulmonary thromboembolism (PTE) causes a dramatic pressure overload to the right heart. Previous case reports have shown that elevated right atrial pressure secondary to a PTE can cause right-to-left shunting in the presence of an atrial septal aneurysm (ASA). A 57-year-old female with diabetes, hypertension, and an old cerebral infarction was admitted to our hospital with acute PTE. Initial transthoracic echocardiography (TTE) showed an ASA swing from the right side to the left side, and r...

  12. Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Jennie L.; Ji, Ping; Ouyang, Nengtai [Division of Cancer Prevention, Stony Brook University, HSC, T17-080, Stony Brook, NY 11794-8173 (United States); Kopelovich, Levy [Division of Cancer Prevention NCI, NIH, Bethesda, MD (United States); Rigas, Basil, E-mail: basil.rigas@stonybrook.edu [Division of Cancer Prevention, Stony Brook University, HSC, T17-080, Stony Brook, NY 11794-8173 (United States)

    2011-06-10

    Nitric oxide-donating aspirin (NO-ASA) is a promising agent for cancer prevention. Although studied extensively, its molecular targets and mechanism of action are still unclear. S-nitrosylation of signaling proteins is emerging as an important regulatory mechanism by NO. Here, we examined whether S-nitrosylation of the NF-{kappa}B, p53, and Wnt signaling proteins by NO-ASA might explain, in part, its mechanism of action in colon cancer. NO-ASA releases significant amounts of NO detected intracellularly in HCT116 and HT-29 colon cells. Using a modified biotin switch assay we demonstrated that NO-ASA S-nitrosylates the signaling proteins p53, {beta}-catenin, and NF-{kappa}B, in colon cancer cells in a time- and concentration-dependent manner. NO-ASA suppresses NF-{kappa}B binding to its cognate DNA oligonucleotide, which occurs without changes in the nuclear levels of the NF-{kappa}B subunits p65 and p50 and is reversed by dithiothreitol that reduces -S-NO to -SH. In addition to S-nitrosylation, we documented both in vitro and in vivo widespread nitration of tyrosine residues of cellular proteins in response to NO-ASA. Our results suggest that the increased intracellular NO levels following treatment with NO-ASA modulate cell signaling by chemically modifying key protein members of signaling cascades. We speculate that S-nitrosylation and tyrosine nitration are responsible, at least in part, for the inhibitory growth effect of NO-ASA on cancer cell growth and that this may represent a general mechanism of action of NO-releasing agents.

  13. The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice.

    Science.gov (United States)

    Guo, Yue; Liu, Yue; Zhang, Chengyue; Su, Zheng-Yuan; Li, Wenji; Huang, Mou-Tuan; Kong, Ah-Ng

    2016-06-01

    Colorectal cancer (CRC) is the third most common cancer worldwide. Chronic inflammation appears to enhance the risk of CRC. Emerging evidence has suggested that epigenetic mechanisms play an important role in CRC. Aspirin [acetylsalicylic acid (ASA)] has been shown to prevent CRC; however, the epigenetic mechanisms of its action remain unknown. This study investigated the protective role of ASA in azoxymethane (AOM)-initiated and dextran sulfate sodium (DSS)-promoted colitis-associated colon cancer (CAC) and examined the epigenetic effects, particularly on histone 3 lysine 27 acetylation (H3K27ac), underlying the preventive effect of ASA. CF-1 mice were fed with AIN-93M diet with or without 0.02% ASA from 1 week prior to AOM initiation until the mice were killed 20 weeks after AOM injection. Our results showed that AOM/DSS + ASA significantly suppressed inflammatory colitis symptoms and tumor multiplicity. AOM/DSS + ASA reduced AOM/DSS-induced protein expression and the activity of histone deacetylases (HDACs) and globally restored H3K27ac. Furthermore, AOM/DSS + ASA inhibited AOM/DSS-induced enrichment of H3K27ac in the promoters of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) that corresponded to the dramatic suppression of the messenger RNA (mRNA) and protein levels. Surprisingly, no significant changes in the H3K27ac abundance in the prostaglandin-endoperoxide synthase 2 (Cox-2) promoters or in the Cox-2 mRNA and protein expression were observed. Collectively, our results suggest that a potential novel epigenetic mechanism underlies the chemopreventive effects of ASA, and this mechanism attenuates CAC in AOM/DSS-induced CF-1 mice via the inhibition of HDACs and the modification of H3K27ac marks that suppress iNOS, TNF-α and IL-6. PMID:27207670

  14. NAC attenuates LPS-induced toxicity in aspirin-sensitized mouse macrophages via suppression of oxidative stress and mitochondrial dysfunction.

    Directory of Open Access Journals (Sweden)

    Haider Raza

    Full Text Available Bacterial endotoxin lipopolysaccharide (LPS induces the production of inflammatory cytokines and reactive oxygen species (ROS under in vivo and in vitro conditions. Acetylsalicylic acid (ASA, aspirin is a commonly used anti-inflammatory drug. Our aim was to study the effects of N-acetyl cysteine (NAC, an antioxidant precursor of GSH synthesis, on aspirin-sensitized macrophages treated with LPS. We investigated the effects of LPS alone and in conjunction with a sub-toxic concentration of ASA, on metabolic and oxidative stress, apoptosis, and mitochondrial function using J774.2 mouse macrophage cell line. Protection from LPS-induced toxicity by NAC was also studied. LPS alone markedly induced ROS production and oxidative stress in macrophage cells. When ASA was added to LPS-treated macrophages, the increase in oxidative stress was significantly higher than that with LPS alone. Similarly, alteration in glutathione-dependent redox metabolism was also observed in macrophages after treatment with LPS and ASA. The combination of LPS and ASA selectively altered the CYP 3A4, CYP 2E1 and CYP 1A1 catalytic activities. Mitochondrial respiratory complexes and ATP production were also inhibited by LPS-ASA treatment. Furthermore a higher apoptotic cell death was also observed in LPS-ASA treated macrophages. NAC pre-treatment showed protection against oxidative stress induced apoptosis and mitochondrial dysfunction. These effects are presumed, at least in part, to be associated with alterations in NF-κB/Nrf-2 mediated cell signaling. These results suggest that macrophages are more sensitive to LPS when challenged with ASA and that NAC pre-treatment protects the macrophages from these deleterious effects.

  15. A metabolomics strategy to explore urinary biomarkers and metabolic pathways for assessment of interaction between Danhong injection and low-dose aspirin during their synergistic treatment.

    Science.gov (United States)

    Li, Jianping; Guo, Jianming; Shang, Erxin; Zhu, Zhenhua; Zhu, Kevin Yue; Li, Shujiao; Zhao, Buchang; Jia, Lifu; Zhao, Jing; Tang, Zhishu; Duan, Jinao

    2016-07-15

    The drug combination of Danhong injection (DHI) and low-dose aspirin (ASA) was frequently applied for the treatment of cardiovascular and cerebrovascular diseases. Due to the drug interactions, a lot of potential benefits and risks might exist side by side in the course of combination therapy. However, there had been no studies of interaction between DHI and ASA. Metabolomics was a powerful tool to explore endogenous biomarkers and metabolic pathways. In present study, metabolic profiling with ultra-high-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UHPLC-QTOF/MS) coupled with multivariate statistical analysis was performed to provide insight into understanding the interaction between DHI and low-dose ASA. Eleven potential biomarkers of three types were identified and seven metabolic pathways were constructed. The results showed that the interaction between DHI and low-dose ASA during synergistic treatment indeed affected some key endogenous biomarkers and metabolic pathways, which could not happen when DHI or low-dose ASA was used alone. The quality and quantity of endogenous metabolite were both influenced by interaction between DHI and low-dose ASA. In details, the amount of flavin mononucleotide, L-2, 4-diaminobutyric acid (DABA) and 4-aminohippuric acid were significantly increased. On the contrary, the amount of 3-methyluridine, 4, 6-dihydroxyquinoline, cortolone-3-glucuronide, and serotonin were significantly decreased. Furthermore, O-phosphotyrosine, 3-methyl-2-butenal, indoxyl sulfate and dolichyl diphosphate were disappeared in urine. As to metabolic pathways, riboflavin metabolism, pentose and glucuronate interconversions, and tryptophan metabolism were all significantly influenced. The emerging alterations of biomarkers and metabolic pathways were associated with a lot of drugs and diseases based on literature researches, which might influence the co-administration of other drugs or the treatments of relevant

  16. Multiple giant succular and fusiform right and left coronary artery aneurysms after early and adequate treatment of atypical kawasaki disease with unusual presentation.

    Directory of Open Access Journals (Sweden)

    Mostafa Behjati-Ardakani

    2014-06-01

    Full Text Available The major complication of Kawasaki disease is coronary artery dilatation and aneurysm. It occurs in approximately 15-25% of untreated children with Kawasaki Disease. Early diagnosis and treatment with Intravenous immune globulin (IVIG and aspirin (ASA can reduce the incidence of coronary artery abnormality to 2%-5%. We report one case of Atypical Kawasaki Disease with Multiple giant coronary artery aneurysms despite early adequate treatment with IVIG and ASA.

  17. A comparative study of efficacy of esmolol and fentanyl for pressure attenuation during laryngoscopy and endotracheal intubation

    OpenAIRE

    Gupta, Shobhana; Tank, Purvi

    2011-01-01

    Objective: To compare the effectiveness of single bolus dose of esmolol or fentanyl in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation. Methods: Ninety adult ASA I and ASA II patients were included in the study who underwent elective surgical procedures. Patients were divided into three groups. Group C (control) receiving 10 ml normal saline, group E (esmolol) receiving bolus dose of esmolol 2 mg/kg and group F (fentanyl) receiving bolus dose of fentanyl ...

  18. Validation of HPLC, DPPH• and nitrosation methods for mesalamine determination in pharmaceutical dosage forms Validação dos métodos de CLAE, DPPH• e nitrosação para determinação de mesalazina em formas farmacêuticas

    OpenAIRE

    Janice Aparecida Rafael; José Roberto Jabor; Rúbia Casagrande; Sandra Regina Georgetti; Maria de Fátima Borin; Maria José Vieira Fonseca

    2007-01-01

    Mesalamine (5-aminosalicylic acid, 5-ASA) is used because of its local effects in the treatment of inflammatory bowel disease. Therefore, the aims of this work were to compare and validate three analytical methods for the quality control of commercial coated tablets containing 5-ASA: high performance liquid chromatography (HPLC), 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH•) and nitrosation. The parameters linearity, precision and accuracy were studied in this work. HPLC with ultraviole...

  19. A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties

    OpenAIRE

    Kastrati, Irida; Litosh, Vladislav A.; Zhao, Shuangping; Alvarez, Manuel; Thatcher, Gregory R.J.; Frasor, Jonna

    2015-01-01

    Introduction Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory drugs have been widely explored as chemopreventive and antineoplastic agents. Aspirin (ASA), in particular, is associated with reduced breast cancer incidence but gastrointestinal toxicity has limited its usefulness. To improve potency and minimize toxicity, ASA ester prodrugs...

  20. Radiolytical oxidation of ascorbic acid in aqueous solutions

    International Nuclear Information System (INIS)

    Complete text of publication follows. Ascorbic acid, AsA (vitamin c), has been widely studied as an antioxidant or as an initiator of some technological processes, for example polymerization or nanoparticles formation. AsA can be easily oxidized to ascorbyl radical, in the first stage, and to dehydroascorbic acid, DHA, in the second stage. It has been found that several different ascorbyl radicals are formed during AsA oxidation but the main radical exists as the anion with the unpaired electron delocalized on a highly conjugated tricarbonyl system. Absorption spectrum of ascorbyl radical shows two bands with maxima at 300 and 360 nm, however only that at 360 nm is proportional to the dose and thus this wavelength was chosen for observations. We studied the oxidation of AsA by the following oxidizing radicals generated by the pulse radiolysis method ·OH, (SCN)2-·, Cl2-·, N3· and NO2·. The observed dependence of the yield and the formation rate of the AsA radical on the reduction potential of the oxidizing radical is discussed. The results obtained in water are compared with those obtained with AsA enclosed in the water pools of reverse micelles formed by AOT in n-heptane or by Igepal CO-520 in c-hexane. Somewhat surprising observation of different ascorbyl radical in pulse irradiated reverse micelles containing DHA is also commented.

  1. An Energy Aware Adaptive Sampling Algorithm for Energy Harvesting WSN with Energy Hungry Sensors.

    Science.gov (United States)

    Srbinovski, Bruno; Magno, Michele; Edwards-Murphy, Fiona; Pakrashi, Vikram; Popovici, Emanuel

    2016-03-28

    Wireless sensor nodes have a limited power budget, though they are often expected to be functional in the field once deployed for extended periods of time. Therefore, minimization of energy consumption and energy harvesting technology in Wireless Sensor Networks (WSN) are key tools for maximizing network lifetime, and achieving self-sustainability. This paper proposes an energy aware Adaptive Sampling Algorithm (ASA) for WSN with power hungry sensors and harvesting capabilities, an energy management technique that can be implemented on any WSN platform with enough processing power to execute the proposed algorithm. An existing state-of-the-art ASA developed for wireless sensor networks with power hungry sensors is optimized and enhanced to adapt the sampling frequency according to the available energy of the node. The proposed algorithm is evaluated using two in-field testbeds that are supplied by two different energy harvesting sources (solar and wind). Simulation and comparison between the state-of-the-art ASA and the proposed energy aware ASA (EASA) in terms of energy durability are carried out using in-field measured harvested energy (using both wind and solar sources) and power hungry sensors (ultrasonic wind sensor and gas sensors). The simulation results demonstrate that using ASA in combination with an energy aware function on the nodes can drastically increase the lifetime of a WSN node and enable self-sustainability. In fact, the proposed EASA in conjunction with energy harvesting capability can lead towards perpetual WSN operation and significantly outperform the state-of-the-art ASA.

  2. Systemic thrombolysis in anterior spinal artery syndrome: what has to be considered?

    Science.gov (United States)

    Koch, Mia; Sepp, Dominik; Prothmann, Sascha; Poppert, Holger; Seifert, Christian L

    2016-04-01

    Anterior spinal artery syndrome (ASAS) often leads to complete motor paralysis with poor clinical outcome. There is a lack of controlled clinical trials on acute treatment strategies in ASAS. However, systemic thrombolysis with recombinant tissue-plasminogen activator (rt-PA) might be a useful therapeutic option in ASAS. We report the management of a patient with ASAS below thoracic level 10, who was treated with intravenous thrombolysis. An 81 year old patient presented with flaccid paraplegia. After exclusion of aortal dissection, spinal tumour or haemorrhage, the patient was treated with intravenous rt-PA 3 h 40 min after symptom onset. The follow up magnetic resonance imaging (MRI) showed spinal infarction below thoracic segment 10. In the clinical course, the patient partially recovered lower limb muscle strength and was able to walk with assistance. To the best of our knowledge, this is the first case in the literature of ASAS with MRI-proven spinal ischemia and the application of rt-PA. Systemic thrombolysis seems to be justifiable in patients with ASAS after the rule-out of aortal dissection and spinal bleeding. PMID:26386968

  3. Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

    Science.gov (United States)

    Cuesta-Gragera, Ana; Navarro-Fontestad, Carmen; Mangas-Sanjuan, Victor; González-Álvarez, Isabel; García-Arieta, Alfredo; Trocóniz, Iñaki F; Casabó, Vicente G; Bermejo, Marival

    2015-07-10

    The objective of this paper is to apply a previously developed semi-physiologic pharmacokinetic model implemented in NONMEM to simulate bioequivalence trials (BE) of acetyl salicylic acid (ASA) in order to validate the model performance against ASA human experimental data. ASA is a drug with first-pass hepatic and intestinal metabolism following Michaelis-Menten kinetics that leads to the formation of two main metabolites in two generations (first and second generation metabolites). The first aim was to adapt the semi-physiological model for ASA in NOMMEN using ASA pharmacokinetic parameters from literature, showing its sequential metabolism. The second aim was to validate this model by comparing the results obtained in NONMEM simulations with published experimental data at a dose of 1000 mg. The validated model was used to simulate bioequivalence trials at 3 dose schemes (100, 1000 and 3000 mg) and with 6 test formulations with decreasing in vivo dissolution rate constants versus the reference formulation (kD 8-0.25 h (-1)). Finally, the third aim was to determine which analyte (parent drug, first generation or second generation metabolite) was more sensitive to changes in formulation performance. The validation results showed that the concentration-time curves obtained with the simulations reproduced closely the published experimental data, confirming model performance. The parent drug (ASA) was the analyte that showed to be more sensitive to the decrease in pharmaceutical quality, with the highest decrease in Cmax and AUC ratio between test and reference formulations. PMID:25869458

  4. Cryopreserved Amniotic Suspension for the Treatment of Knee Osteoarthritis.

    Science.gov (United States)

    Vines, Jeremy B; Aliprantis, Antonios O; Gomoll, Andreas H; Farr, Jack

    2016-08-01

    There are few treatment options for symptomatic knee osteoarthritis (OA). Human amniotic suspension allografts (ASA) have anti-inflammatory and chondroregenerative potential and thus represent a promising treatment strategy. In anticipation of a large, placebo-controlled trial of intra-articular ASA for symptomatic knee OA, an open-label prospective feasibility study was performed. Six patients with Kellgren-Lawrence grades 3 and 4 tibiofemoral knee OA were administered a single intra-articular ASA injection containing cryopreserved particulated human amnion and amniotic fluid cells. Patients were followed for 12 months after treatment. No significant injection reactions were noted. Compared with baseline there were (1) no significant effect of the ASA injection on blood cell counts, lymphocyte subsets, or inflammatory markers and (2) a small, but statistically significant increase in serum IgG and IgE levels. Patient-reported outcomes including International Knee Documentation Committee, Knee Injury and Osteoarthritis Outcome, and Single Assessment Numeric Evaluation scores were collected throughout the study and evaluated for up to 12 months. Overall, this study demonstrates the feasibility of a single intra-articular injection of ASA for the treatment of knee OA and provides the foundation for a large placebo-controlled trial of intra-articular ASA for symptomatic knee OA. PMID:26683979

  5. Stochastic Global Optimization and Its Applications with Fuzzy Adaptive Simulated Annealing

    CERN Document Server

    Aguiar e Oliveira Junior, Hime; Petraglia, Antonio; Rembold Petraglia, Mariane; Augusta Soares Machado, Maria

    2012-01-01

    Stochastic global optimization is a very important subject, that has applications in virtually all areas of science and technology. Therefore there is nothing more opportune than writing a book about a successful and mature algorithm that turned out to be a good tool in solving difficult problems. Here we present some techniques for solving  several problems by means of Fuzzy Adaptive Simulated Annealing (Fuzzy ASA), a fuzzy-controlled version of ASA, and by ASA itself. ASA is a sophisticated global optimization algorithm that is based upon ideas of the simulated annealing paradigm, coded in the C programming language and developed to statistically find the best global fit of a nonlinear constrained, non-convex cost function over a multi-dimensional space. By presenting detailed examples of its application we want to stimulate the reader’s intuition and make the use of Fuzzy ASA (or regular ASA) easier for everyone wishing to use these tools to solve problems. We kept formal mathematical requirements to a...

  6. Identification of the segmental artery feeding the anterior spinal artery. Correlation between helical CT and angiography

    International Nuclear Information System (INIS)

    We investigated whether identification of the segmental artery feeding the anterior spinal artery (ASA) is possible by single-slice helical CT. Enhanced CT and angiography were performed in 14 patients with retroperitoneal, liver, or bone tumor. A single-slice helical CT scanner with 7 mm collimation and a 1.0 helical pitch was used. Scanning was started 25 to 30 sec after an intravenous injection of 100 ml of contrast medium at a rate of 3.0 ml/sec. We predicted the segmental artery feeding the ASA in all 14 patients using enhanced CT images. In 12 of the 14 patients, the segmental artery feeding the ASA was angiographically identified. In 7 of these 12 patients, the level of the segmental artery feeding the ASA identified on segmental arteriogram was the same level as that predicted by enhanced CT. In the remaining 5 patients, the level of the segmental artery feeding the ASA identified on segmental arteriogram was one level higher or lower than the predicted spinal level. We could identify the segmental artery feeding the ASA by detailed examination and interpretation of single-slice helical CT images. (author)

  7. The study of acetylsalicylic acid effects on wheat seeds germination in salt stress conditions

    Directory of Open Access Journals (Sweden)

    Sorin Tănasa

    2010-12-01

    Full Text Available The present study was conducted in order to determine whether a treatment using acetylsalicylic acid (ASA would increase the germinative energy of wheat seeds in conditions of salt stress. Wheat seeds were immersed in six solutions of ASA of different concentrations (0, 0.1, 0.5, 1, 2 and 3 mM and then germinated in two solutions of different levels of salinity (one replicating normal conditions of salinity in crop soils, and one reproducing the conditions present in salty soil. The optimum concentration ofASA for alleviating the effects of salt stress proved to be 1 mM. The enzymatic activities of three antioxidant enzymes (catalase, peroxidase and poliphenoloxidase were also monitored in all theexperimental variants to determine whether the effects of the ASA on wheat seeds germination were due to its effects on the antioxidant system. The treatment using ASA in 1 mM concentration increased,in high salinity conditions, foremost the catalase activity and less the peroxidase and poliphenoloxidase activity, making catalase the most indicative enzyme in explaining the effects of ASA on saline stress reduction.

  8. Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators

    Directory of Open Access Journals (Sweden)

    Thomas Köhnke

    2013-01-01

    Full Text Available The role of non-steroidal anti-inflammatory drugs in inflammatory bowel disease is controversial, as they have been implicated in disease aggravation. Different from other cyclooxygenase inhibitors, acetylsalicylic acid (ASA enhances the formation of anti-inflammatory and proresolution lipoxins derived from arachidonic acid as well as resolvins from omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA. In this study, we examined the effect of ASA on murine dextran sodium sulfate colitis. A mouse magnetic resonance imaging (MRI protocol and post mortem assessment were used to assess disease severity, and lipid metabolites were measured using liquid chromatography-coupled tandem mass spectrometry. Decreased colitis activity was demonstrated by phenotype and MRI assessment in mice treated with ASA, and confirmed in postmortem analysis. Analysis of lipid mediators showed sustained formation of lipoxin A4 and an increase of DHA-derived 17-hydroxydocosahexaenoic acid (17-HDHA after treatment with ASA. Furthermore, in vitro experiments in RAW264.7 murine macrophages demonstrated significantly increased phagocytosis activity after incubation with 17-HDHA, supporting its proresolution effect. These results show a protective effect of ASA in a murine colitis model and could give a rationale for a careful reassessment of ASA therapy in patients with inflammatory bowel disease and particularly ulcerative colitis, possibly combined with DHA supplementation.

  9. Mortality in perforated duodenal ulcer depends upon pre-operative risk: a retrospective 10-year study.

    LENUS (Irish Health Repository)

    Larkin, J O

    2012-01-31

    INTRODUCTION: Most patients presenting with acutely perforated duodenal ulcer undergo operation, but conservative treatment may be indicated when an ulcer has spontaneously sealed with minimal\\/localised peritoneal irritation or when the patient\\'s premorbid performance status is poor. We retrospectively reviewed our experience with operative and conservative management of perforated duodenal ulcers over a 10-year period and analysed outcome according to American Society of Anesthesiologists (ASA) score. METHODS: The records of all patients presenting with perforated duodenal ulcer to the Department of Surgery, Mayo General Hospital, between January 1998 and December 2007 were reviewed. Age, gender, co-morbidity, ASA-score, clinical presentation, mode of management, operative procedures, morbidity and mortality were considered. RESULTS: Of 76 patients included, 48 (44 operative, 4 conservative) were ASA I-III, with no mortality irrespective of treatment. Amongst 28 patients with ASA-score IV\\/V, mortality was 54.5% (6\\/11) following operative management and 52.9% (9\\/17) with conservative management. CONCLUSION: In patients with a perforated duodenal ulcer and ASA-score I-III, postoperative outcome is uniformly favourable. We recommend these patients have repair with peritoneal lavage performed, routinely followed postoperatively by empirical triple therapy. Given that mortality is equivalent between ASA IV\\/V patients whether managed operatively or conservatively, we suggest that both management options are equally justifiable.

  10. Influence of antisperm antibodies in the semen on intracytoplasmic sperm injection outcome

    Directory of Open Access Journals (Sweden)

    Sandro C. Esteves

    2007-12-01

    Full Text Available OBJECTIVE: The aim of this study was to analyze the influence of autoantibodies against spermatozoa present in the semen on the outcome of in vitro fertilization with intracytoplasmic sperm injection (ICSI. MATERIALS AND METHODS: We performed a retrospective analysis of clinical and laboratorial data from a six year-period ICSI cycles. Screening for the presence of ASA in the semen, by using the direct immunobeads test (IBT, was available for 351 cycles. According to the percentage of antibody-bound spermatozoa in the semen, we divided the cycles in four groups: I (n = 194: 0%-10% ASA; II (n = 107: 11%-20%; III (n = 33: 21%-50% and IV (n = 17: 51%-100% ASA. Additionally, a group of 349 ICSI cycles performed with ejaculated spermatozoa from oligo/asthenozoospermic men who had insufficient number of motile sperm available for ASA screening was included for comparison. ICSI outcomes were compared among groups and included fertilization rate (2 PN, cleavage rate, cleavage velocity, embryo quality, clinical pregnancy and miscarriage rates. Data were examined statistically, with an alpha level of 5% considered significant. RESULTS: Fertilization, cleavage rate and velocity, percentage of good quality embryos, as well as clinical pregnancy and miscarriage rates did not differ among different ASA levels groups. ICSI outcomes in men exhibiting different levels of autoimmunity against spermatozoa did not differ from those with severely abnormal seminal parameters. CONCLUSIONS: Our data indicate that intracytoplasmic sperm injection (ICSI outcomes are not influenced by ASA levels on sperm.

  11. Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: A net clinical benefit analysis using a 'real world' nationwide cohort study

    DEFF Research Database (Denmark)

    Olesen, Jonas Bjerring; Lip, Gregory Y H; Lindhardsen, Jesper;

    2011-01-01

    It was the aim of this study to determine the efficacy and safety of vitamin K antagonists (VKAs) and acetylsalicylic acid (ASA) in patients with non-valvular atrial fibrillation (AF), with separate analyses according to predicted thromboembolic and bleeding risk. By individual level-linkage of n......It was the aim of this study to determine the efficacy and safety of vitamin K antagonists (VKAs) and acetylsalicylic acid (ASA) in patients with non-valvular atrial fibrillation (AF), with separate analyses according to predicted thromboembolic and bleeding risk. By individual level...... lowered the risk of thromboembolism compared to ASA and no treatment; the combination of VKA+ASA did not yield any additional benefit. In patients at high thromboembolic risk, hazard ratios (95% confidence interval) for thromboembolism were: 1.81 (1.73-1.90), 1.14 (1.06-1.23), and 1.86 (1.78-1.95) for ASA....... There was a neutral or positive net clinical benefit (ischaemic stroke vs. intracranial haemorrhage) with VKA alone in patients with a CHADS2 score of = 0, and CHA2DS2-VASc score of = 1. This large cohort study confirms the efficacy of VKA and no effect of ASA treatment on the risk of stroke/thromboembolism. Also...

  12. Enhanced Glucose Tolerance and Pancreatic Beta Cell Function by Low Dose Aspirin in Hyperglycemic Insulin-Resistant Type 2 Diabetic Goto-Kakizaki (GK Rats

    Directory of Open Access Journals (Sweden)

    Layla Amiri

    2015-07-01

    Full Text Available Background/Aim: Type 2 diabetes is the most common metabolic disorder, characterized by insulin resistance and pancreatic islet beta-cell failure. The most common complications associated with type 2 diabetes are hyperinsulinemia, hyperglycemia, hyperlipidemia, increased inflammatory and reduced insulin response. Aspirin (ASA and other non-steroidal anti-inflammatory drugs (NSAIDs have been associated with the prevention of diabetes, obesity and related cardiovascular disorders. Aspirin has been used in many clinical and experimental trials for the prevention of diabetes and associated complications. Methods: In this study, five month old Goto-Kakizaki (GK rats, which showed signs of mild hyperglycemia (fasting blood glucose 80-95 mg/dl vs 55-60 mg/dl Wistar control rats were used. Two subgroups of GK and Wistar control rats were injected intraperitoneally with 100 mg aspirin/kg body weight/ day for 5 weeks. Animals were sacrificed and blood and tissues were collected after performing glucose tolerance (2 h post 2g IP glucose ingestion tests in experimental and control groups. Results: Aspirin caused a moderate decrease in hyperglycemia. However, we observed a significant improvement in glucose tolerance after ASA treatment in GK rats compared to the nondiabetic Wistar rats. Also, the ASA treated GK rats exhibited a significant decrease in insulinemia. ASA treatment also caused a marked reduction in the pro-inflammatory prostaglandin, PGE2, which was significantly higher in GK rats. On the other hand, no significant organ toxicity was observed after ASA treatment at this dose and time period. However, the total cholesterol and lipoprotein levels were significantly increased in GK rats, which decreased after ASA treatment. Immunofluorescence staining for insulin/glucagon secreting pancreatic cells showed improved beta-cell structural and functional integrity in ASA-treated rats which was also confirmed by SDS-PAGE and Western blot analysis

  13. Pharmacokinetics and plasma concentrations of acetylsalicylic acid after intravenous, rectal, and intragastric administration to horses.

    Science.gov (United States)

    Broome, Ted A; Brown, Murray P; Gronwall, Ronald R; Casey, Matthew F; Meritt, Kelly A

    2003-10-01

    Six healthy adult horses (5 mares and 1 stallion) were given a single dose of acetylsalicylic acid (ASA), 20 mg/kg of body weight, by intravenous (IV), rectal, and intragastric (IG) routes. Serial blood samples were collected via jugular venipuncture over a 36-h period, and plasma ASA and salicylic acid (SA) concentrations were determined by high-performance liquid chromatography. After IV administration, the mean elimination rate constant of ASA (+/- the standard error of the mean) was 1.32 +/- 0.09 h(-1), the mean elimination half-life was 0.53 +/- 0.04 h, the area under the plasma concentration-versus-time curve (AUC) was 2555 +/- 98 microg x min/mL, the plasma clearance was 472 +/- 18.9 mL/h/kg, and the volume of distribution at steady state was 0.22 +/- 0.01 L/kg. After rectal administration, the plasma concentration of ASA peaked at 5.05 +/- 0.80 microg/mL at 0.33 h, then decreased to undetectable levels by 4 h; the plasma concentration of SA peaked at 17.39 +/- 5.46 microg/mL at 2 h, then decreased to 1.92 +/- 0.25 microg/mL by 36 h. After rectal administration, the AUC for ASA was 439.4 +/- 94.55 microg x min/mL and the bioavailability was 0.17 +/- 0.037. After IG administration, the plasma concentration of ASA peaked at 1.26 +/- 0.10 microg/mL at 0.67 h, then declined to 0.37 +/- 0.37 microg/mL by 36 h; the plasma concentration of SA peaked at 23.90 +/- 4.94 microg/mL at 4 h and decreased to 0.85 +/- 0.31 microg/mL by 36 h. After IG administration, the AUC for ASA was 146.70 +/- 24.90 microg x min/mL and the bioavailability was 0.059 +/- 0.013. Administration of a single rectal dose of ASA of 20 mg/kg to horses results in higher peak plasma ASA concentrations and greater bioavailability than the same dose given IG. Plasma ASA concentrations after rectal administration should be sufficient to inhibit platelet thromboxane production, and doses lower than those suggested for IG administration may be adequate. PMID:14620867

  14. Soil Science Society of America - K-12 Outreach

    Science.gov (United States)

    Lindbo, David L.; Loynachan, Tom; Mblia, Monday; Robinson, Clay; Chapman, Susan

    2013-04-01

    The Soil Science Society of America created its K12 Committee in 2006 in part to compliment the Dig It! The Secrets of Soil exhibit that opened in July 2008 at the Smithsonian's Institution's Nation Museum of Natural History (of which SSS was a founding sponsor). The committee's work began quickly with a website designed to provide resources for K12 teachers. The first accomplishments included reviewing and posting links to web based information already available to teachers. These links were sorted by subject and grade level to make it easier for teachers to navigate the web and find what they needed quickly. Several presentations and lessons designed for K12 teachers were also posted at this time. Concurrent with this effort a subcommittee review and organized the national teaching standards to show where soils could fit into the overall K12 curriculum. As the website was being developed another subcommittee developed a soils book (Soil! Get the Inside Scoop, 2008) to further compliment the Dig It! exhibit. This was a new endeavor for SSSA having never worked with the non-academic audience in developing a book. Peer-reviews of this book included not only scientist but also students in order to make sure the book was attractive to them. Once the book was published and the website developed it became clear more outreach was needed. SSSA K12 Committee has attended both the National Science Teachers Association (since 2008) the USA Science and Engineering Festival (since 2010) with exhibits and workshops. It has cooperated and contributed to the American Geologic Institutes' Earth Science Week materials with brochures and lesson plans and with National Association of Conservation Districts by providing peer-review and distribution of materials. The most recent developments from the committee include a web redesign that is more student and teacher friendly, the development of a peer-review system to publish K12 Lesson Plans, and finally the publication of a new soils

  15. Purification and Characterization of Suicin 65, a Novel Class I Type B Lantibiotic Produced by Streptococcus suis.

    Directory of Open Access Journals (Sweden)

    Katy Vaillancourt

    Full Text Available Bacteriocins are antimicrobial peptides of bacterial origin that are considered as a promising alternative to the use of conventional antibiotics. Recently, our laboratory reported the purification and characterization of two lantibiotics, suicin 90-1330 and suicin 3908, produced by the swine pathogen and zoonotic agent Streptococcus suis (serotype 2. In this study, a novel bacteriocin produced by S. suis has been identified and characterized. The producing strain S. suis 65 (serotype 2 was found to belong to the sequence type 28, that includes strains known to be weakly or avirulent in a mouse model. The bacteriocin, whose production was only possible following growth on solid culture medium, was purified to homogeneity by cationic exchange and reversed-phase high-pressure liquid chromatography. The bacteriocin, named suicin 65, was heat, pH and protease resistant. Suicin 65 was active against all S. suis isolates tested, including antibiotic resistant strains. Amino acid sequencing of the purified bacteriocin by Edman degradation revealed the presence of modified amino acids suggesting a lantibiotic. Using the partial sequence obtained, a blast was performed against published genomes of S. suis and allowed to identify a putative lantibiotic locus in the genome of S. suis 89-1591. From this genome, primers were designed and the gene cluster involved in the production of suicin 65 by S. suis 65 was amplified by PCR. Sequence analysis revealed the presence of ten open reading frames, including a duplicate of the structural gene. The structural genes (sssA and sssA' of suicin 65 encodes a 25-amino acid residue leader peptide and a 26-amino acid residue mature peptide yielding an active bacteriocin with a deducted molecular mass of 3,005 Da. Mature suicin 65 showed a high degree of identity with class I type B lantibiotics (globular structure produced by Streptococcus pyogenes (streptococcin FF22; 84.6%, Streptococcus macedonicus (macedocin ACA

  16. Aspirin or Nonsteroidal Anti-inflammatory Drug-Exacerbated Chronic Rhinosinusitis.

    Science.gov (United States)

    Ledford, Dennis K; Lockey, Richard F

    2016-01-01

    Aspirin (ASA)-exacerbated respiratory disease (AERD) is characterized by upper airway congestion due to eosinophilic inflammation of the nasal and sinus membranes and nasal polyposis, associated with increased leukotriene production that is further accentuated by ASA or other nonsteroidal anti-inflammatory drug (NSAID) ingestion. It occurs in 5% to 10% of subjects with chronic rhinosinusitis (CRS) and in 15% to 40% of those with nasal polyposis. Although AERD with CRS is usually associated with asthma, this is not always the case. The eosinophilic airway inflammation and symptoms precede clinical reactions to ASA or other NSAIDs, but ultimately affected subjects experience worsening of symptoms with ingestion of ASA/NSAIDs. The endotypic mechanism for this worsening is related to a chronic increase in leukotriene and a decrease in prostaglandin production, particularly prostaglandin E2, that is further aggravated by the inhibition of cycloxgenase I. IgE does not likely play a role in the pathogenesis of the disease although nasal and sinus staphylococcal infection increases local IgE level and may increase total IgE and specific IgE levels. Genetic studies suggest that multiple genes may be involved, but the genetic abnormalities may differ in affected subjects from different ethnicities and candidate genes have not been confirmed in multiple studies. Genome-wide association studies have not been revealing. The phenotype is recognized by the mucosal inflammation and worsening of symptoms acutely with ASA/NSAID. There is clinical improvement with ASA desensitization followed by regular ingestion of ASA or other NSAIDs. Further understanding of this unique phenotype and endotype of CRS will likely improve the understanding of other eosinophilic airway diseases. PMID:27393773

  17. Prevalence of psoriatic arthritis in psoriasis patients according to newer classification criteria.

    Science.gov (United States)

    Maldonado Ficco, Hernán; Citera, Gustavo; Maldonado Cocco, José Antonio

    2014-02-01

    The aim of this study is to determine the prevalence of psoriatic arthritis (PsA) according to CASPAR criteria, ASAS peripheral and axial SpA criteria, and New York criteria for AS. The first 100 patients consecutively attending a psoriasis dermatology clinic were assessed. Demographic and clinical data were collected; all patients were questioned and examined for joint manifestations. Rheumatoid factor and radiographies of hands, feet, cervical spine, and pelvis for sacroiliac joints were obtained. X-rays were read independently by two experienced observers in blind fashion. Patients with objective joint manifestations, both axial and peripheral, were evaluated for fulfillment of CASPAR, ASAS peripheral and axial, and New York criteria. Median age 48 years; 93 % of patients had psoriasis vulgaris and 56 % nail involvement. Seventeen patients had peripheral arthritis as follows: nine mono/oligoarticular and eight polyarthritis. Median arthritis duration was 8 years. Seventeen percent of patients fulfilled CASPAR and ASAS peripheral criteria, 6 % New York, and 5 % ASAS axial criteria. Patients who met CASPAR criteria showed a significantly higher psoriasis duration compared to those without arthritis (M 16 vs. 10 years, p = 0.02), and a higher frequency of nail involvement (88.2 vs. 49.4 %, p = 0.003). Five patients (29.4 %) fulfilled ASAS axial criteria; all of them had peripheral involvement as follows: mono/oligoarticular in three patients and polyarticular in two. Patients with peripheral and axial involvement presented a significantly higher frequency of erythrodermic psoriasis compared to the other patients (35.3 vs. 1.2 %, p = 0.0006 and 80 vs. 16.7 %, p = 0.02). Prevalence of PsA, for CASPAR and ASAS peripheral criteria, was of 17 %. Five percent of patients met ASAS axial criteria, while 6 % met New York criteria. Worth noting, few patients without signs or symptoms of arthritis had radiological changes, both axial and peripheral, precluding

  18. Diagnosis of asymptomatic atrial septal aneurysms using two-dimensional color Doppler and contrast transthoracic echocardiography

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective To evaluate the dimensions of atrial septal aneurysm (ASA), the presence and characteristics of interatrial shunt, the movement of the wall of the aneurysm, and correlation between these findings and sign and/or symptoms suggesting embolism in Manisa, a district of a western Anatolian city of Turkey. Methods Two thousand five hundred cases were examined by routine transthoracic echocardiography (TTE) in both pediatric and adult cardiology outpatient clinics. ASA was detected in 20 cases and evaluated by two-dimensional color Doppler echocardiography (CDE). The length of the base, the maximum radius and the maximum displacement of ASA were measured. The shunt between the atria was examined by CDE. In cases where a shunt could not be found, galactose and palmitic acid was injected. Standard 12-lead electrocardiogram (ECG) and exercise stress test were also performed. Results No clinical signs or symptoms were found, suggesting a systemic or cerebral embolism. The maximum displacement of ASA was between 2 and 5 mm. All of the aneurysms were localized in the right atrium, and the walls of the aneurysm did not move beyond the base of the left atrium during the maximum displacement. Interatrial shunt was detected in 14 of 20 patients (70%) by CDE and in the remaining six cases by contrast TTE. Frequent ventricular ectopic beats were observed in one patient. Conclusions During routine TTE we observed 0.8% asymptomatic ASA in our population. The use of a contrast agent was found to be a valuable additional method in patients with ASA when the shunt could not be detected by CDE. The risk for embolism is not high when the maximum displacement of the wall of ASA was 5 mm or less and no bulge into the left atrium was observed. Based on our experience with this method, TTE is easy to perform, well-tolerated and acceptable.

  19. Synthesis of Chromium (Ⅲ) 5-aminosalicylate

    Institute of Scientific and Technical Information of China (English)

    LI Wei; HAO Er-jun; JIANG Yu-qin

    2004-01-01

    As we all known that diabetes is a chronic disease with major health consequences.Research has revealed that the occurrence of diabetes have great thing to do with the chromium deficient. Almost 40 years after the first report of glucose tolerance factor(GTF) [1], no conclusive evidence for an isolable ,biologically active form of chromium exited. Three materials have been proposed to be the biologically active form of chromium: "glucose tolerance factor", chromium Picolinate and low-molecular-weight chromium-binding substance (LWMCr) [2] . So there is potential for the design of new chromium drugs .5-Aminosalicylic acid (5-ASA) is identified as an active component in the therapy of inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis . The therapeutic action of 5-ASA is believed to be coupled to its ability to act as a free radical scavenger [3-4],acting locally on the inflamed colonic mucosa [5-7]. However, the clinical use of 5-ASA is limited, since orally administered 5-ASA is rapidly and completely absorbed from the upper gastrointestinal tract and therefore the local therapeutic effects of 5-ASA in the colon is hardly expected.In this paper, we report the synthesis of chromium(Ⅲ)5-aminosalicylate from 5-ASA and CrCl3. 6H2O.The synthesis route is as follow:The complex has been characterized by elemental analysis, IR spectra, X-ray powder diffractionand TG-DTA . They indicate that the structure is tris(5-ASA) Chromium . Experiments show that thecomplex has a good activity for supplement tiny dietary chromium, lowering blood glucose levels,lowering serum lipid levels and in creasing lean body mass .

  20. Platelet thromboxane (11-dehydro-Thromboxane B2) and aspirin response in patients with diabetes and coronary artery disease.

    Science.gov (United States)

    Lopez, Luis R; Guyer, Kirk E; Torre, Ignacio Garcia De La; Pitts, Kelly R; Matsuura, Eiji; Ames, Paul Rj

    2014-04-15

    Aspirin (ASA) irreversibly inhibits platelet cyclooxygenase-1 (COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes (DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2 (11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls (P = 0.024): female subjects (DM and controls) had 50.9% higher baseline 11dhTxB2 than males (P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM (71.7%) and controls (75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders (ASA "resistant") in DM than in controls (14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome (ACS) patients was 28.6 and 28.7%, in spite of a significant (81.6%) inhibition of urinary 11dhTxB2 (P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. PMID:24748925

  1. The role of antioxidant system in freezing acclimation-induced freezing resistance of Populus suaveolens cuttings

    Institute of Scientific and Technical Information of China (English)

    Luo Lei; Lin Shan-zhi; Zheng Hui-quan; Lei Yang; Zhang Qian; Zhang Zhi-yi

    2007-01-01

    We investigated the changes in the contents of H2O2, malonaldehyde (MDA) and endogenous antioxidants, the activities of protective enzymes and some critical enzymes involved in the ascorbate-glutathione (ASA-GSH) cycle as well as freezing resistance(expressed as LT50) and correlations mentioned above, in detail using Populus suaveolens cuttings. The purpose was to explore the physiological mechanism of the enhancement of freezing resistance induced by freezing acclimation at -20℃, and to elucidate the physiological mechanisms by which trees adapt to freezing. The results showed that freezing acclimation enhanced the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), monodehydroascorbate reductase (MDAR), ascorbate peroxidase(APX), dehydroascorbate reductase (DHAR) and glutathione reductase (GR). And it increased the contents of reduced ascorbate(ASA), reduced glutathione (GSH), dehydroascorbate (DHA) and oxidized glutathione (GSSG). However, H2O2 and MDA contents and LT50 of cuttings were decreased. LT50 in cuttings was found to be closely correlated to the levels of SOD, POD, CAT, APX,DHAR, MDAR, GR, H2O2, MDA, ASA, GSH, DHA and GSSG during freezing acclimation. This suggested that the enhancement of freezing resistance of cuttings induced by freezing acclimation may relate to the distinct increase for the levels of SOD, POD, CAT,APX, DHAR, MDAR,GR,ASA, GSH, DHA, and GSSG. In addition, the observed levels of APX, DHAR, MDAR, GR, ASA, DHA,GSH and GSSG were higher than those of SOD, POD and CAT during freezing acclimation. It indicated that a higher capacity of the ASA-GSH cycle is required for H2O2 detoxification, and growth and development of cuttings. Based on the obtained results, it can be concluded that the ASA-GSH cycle plays an important role in enhancement of freezing resistance of P. suaveolens cuttings during freezing acclimation.

  2. Strong and long-lasting antinociceptive and anti-inflammatory conjugate of naturally occurring oleanolic acid and aspirin

    Directory of Open Access Journals (Sweden)

    Barbara Bednarczyk-Cwynar

    2016-07-01

    Full Text Available The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7 and aspirin in dioxane. Analgesic effect of OAO-ASA (8 for the range of doses 0.3 – 300.0 mg/kg (p.o. was performed in mice using a hot plate test. Anti-inflammatory activity was assessed on carrageenan-induced paw edema in rats for the same range of doses. The conjugate OAO-ASA (8 did not significantly change locomotor activity of mice, therefore sedative properties of the compound should be excluded. The compound 8 proved a simple, proportional, dose-dependent analgesic action and expressed strong anti-inflammatory activity showing a reversed U-shaped, dose-dependent relation with its maximum at 30.0 mg/kg. After its combined administration with morphine (MF, 5.0 mg/kg, s.c. the lowering of antinociceptive activity was found; however, the interaction with naloxone (NL, 3.0 mg/kg, s.c. did not affect the antinociceptive effect of OAO-ASA (8, therefore its opioid mechanism of action should be rather excluded. After combined administration with acetylsalicylic acid (ASA, 300.0 mg/kg, p.o. in hot-plate test, the examined compound 8 enhanced the antinociceptive activity in significant way. It also shows that rather the whole molecule is responsible for the antinociceptive and anti-inflammatory effect of the tested compound 8, however it cannot be excluded that the summarizing effect is produced by ASA released from the compound 8 and the rest of triterpene derivative. The occurrence of tolerance for triterpenic derivative 8 was not observed, since the analgesic and anti-inflammatory effects after chronic administration of the conjugate OAO-ASA (8 was on the same level as after its single treatment. It seemed that the anti-inflammatory mechanism of action of OAO-ASA (8 is not simple, even its chronic administration lowered both blood concentration of IL-6 and mRNA IL-6 expression. However, the effects of the conjugate OAO-ASA (8 on TNF-α level

  3. Fratura do quadril: avaliação pós-operatória do resultado clínico e funcional Hip fracture: post-operative evaluation of clinical and functional outcomes

    Directory of Open Access Journals (Sweden)

    Marcelo Teodoro Ezequiel Guerra

    2010-01-01

    Full Text Available OBJETIVO: Avaliar o resultado clínico e funcional dos pacientes submetidos à cirurgia por fratura do quadril relacionando com o escore ASA e com tempo para o tratamento cirúrgico definitivo. MÉTODOS: No período de um ano foram operados 154 pacientes com 65 anos ou mais, com fratura do quadril. Dados sobre o escore pré-operatório ASA e sobre o tempo de espera para a cirurgia foram obtidos. Dois anos após a cirurgia, foi aplicado o questionário Escore de Recuperação Funcional de Zuckerman (ERF como examinadorda capacidade funcional atual dos pacientes. RESULTADOS: A mortalidade no primeiro ano pós-operatório apresentou diferença entre pacientes com ASA 3 ou 4 em relação aos classificados como ASA 1 ou 2 (dado significante p OBJECTIVE: To evaluate the clinical and functional outcomes of patients submitted to surgery for hip fracture through the ASA score and time for definitive surgical treatment. METHOD: During one year, 154 patients with hip fractures, aged 65 years and over, were operated on. Data from the pre-operative ASA score and time awaiting operation were obtained. Two years after the operation, Zuckerman's Functional Recovery Score (FRS questionnaire was used to assess the current functional capacity of the patients. RESULTS: Mortality in the first post-operative year was different between patients with an ASA 3 or 4 compared to those classified as ASA 1 or 2 group (significant data p0.05. There was no significant difference between the group operated within 48 hours of admission and the group operated after 48 hours in relation to mortality or current functional capacity (p>0.05. The group aged 80 and over showed significantly higher mortality than the group aged 65 to 79 years through the end of the second post-operative year (p>0.05. CONCLUSION: A preoperative ASA score and an age of 80 or over may be considered factors associated with higher mortality two years post-operatively after hip fracture. In isolation, time

  4. Ondansetron reduces naturalistic drinking in non-treatment seeking alcohol dependent individuals with the LL 5′-HTTLPR genotype: a laboratory study

    Science.gov (United States)

    Kenna, George A.; Zywiak, William H.; Swift, Robert M.; McGeary, John E.; Clifford, James S.; Shoaff, Jessica R.; Vuittonet, Cynthia; Fricchione, Samuel; Brickley, Michael; Beaucage, Kayla; Haass-Koffler, Carolina L.; Leggio, Lorenzo

    2014-01-01

    Background One hypothesis suggests that the differential response to ondansetron and serotonin specific re-uptake inhibitors (SSRIs) may be due to a functional polymorphism of the 5′-HTTLPR promoter region in SLC6A4, the gene that codes for the serotonin transporter (5-HTT). The LL 5′-HTTLPR genotype is postulated to be specifically sensitive to the effects of ondansetron with SS/SL 5′-HTTLPR genotypes sensitive to SSRIs. This study tests this hypothesis by matching non-treatment seeking alcohol dependent (AD) individuals with LL genotype to ondansetron and SS/SL genotypes to the SSRI sertraline, and mis-matching them assessing naturalistic and bar-laboratory alcohol drinking. Methods Seventy-seven AD individuals were randomized to one of two counterbalanced arms to receive sertraline 200mg/day or ondansetron 0.5 mg/day for three weeks followed by an alcohol self-administration experiment (ASAE), then received placebo for three weeks followed by a second ASAE. Individuals then received the alternate drug for three weeks followed by a third ASAE. Drinks per drinking day (DDD with drinks in SDUs) for 7 days prior to each ASAE and milliliters consumed during each ASAE were the primary outcomes. Results Fifty-five participants completed the study. The genotype x order interaction was significant [F(1,47) = 8.42, p = .006] for DDD. Three ANCOVAs were conducted for DDD during the week before each ASAE. Ondansetron compared to sertraline resulted in a significant reduction in DDD during the week before the first [F(1,47) = 7.64, p = .008] but not the third ASAE. There was no difference in milliliters consumed during each ASAE. Conclusion This study modestly supports the hypothesis that ondansetron may reduce DDD in AD individuals with the LL genotype as measured naturalistically. By contrast there was no support that ondansetron reduces drinking during the ASAEs or that sertraline reduces alcohol use in individuals who have SS/SL genotypes. We provide limited

  5. Rapid degradation of p-arsanilic acid with simultaneous arsenic removal from aqueous solution using Fenton process.

    Science.gov (United States)

    Xie, Xiande; Hu, Yuanan; Cheng, Hefa

    2016-02-01

    Although banned in some developed countries, p-arsanilic acid (p-ASA) is still used widely as a feed additive for swine production in many countries. With little uptake and transformation in animal bodies, nearly all the p-ASA administered to animals is excreted chemically unchanged in animal wastes, which can subsequently release the more toxic inorganic arsenic species upon degradation in the environment. For safe disposal of the animal wastes laden with p-ASA, we proposed a method of leaching the highly water-soluble p-ASA out of the manure first, followed by treatment of the leachate using the Fenton process to achieve fast oxidation of p-ASA and removal of the inorganic arsenic species released (predominantly arsenate) from solution simultaneously. The effects of solution pH, dosages of H2O2 and Fe(2+), and the presence of dissolved organic matter (DOM) on the treatment efficiency were systematically investigated. Under the optimum treatment conditions (0.53 mmol L(-1) Fe(2+), 2.12 mmol L(-1) H2O2, and initial pH of 3.0), p-ASA (10 mg-As L(-1)) could be completely oxidized to As(V) within 30 min in pure water and 4 natural water samples, and at the final pH of 4.0, the residual arsenic levels in solution phase were as low as 1.1 and 20.1-43.4 μg L(-1) in the two types of water matrixes, respectively. The presence of humic acid significantly retarded the oxidation of p-ASA by scavenging HO, and inhibited the As(V) removal through competitive adsorption on ferric hydroxide. Due to the high contents of DOM in the swine manure leachate samples (TOC at ∼500 mg L(-1)), much higher dosages of Fe(2+) (10.0 mmol L(-1)) and H2O2 (40.0 mmol L(-1)) and a longer treatment time (120 min) were required to achieve near complete oxidation of p-ASA (98.0%), while maintaining the levels of residual arsenic in the solution at products detected. Together, the results demonstrate that the Fenton process is promising as an efficient, robust, and low-cost treatment

  6. Recycling ground granulated blast furnace slag as cold bonded artificial aggregate partially used in self-compacting concrete.

    Science.gov (United States)

    Gesoğlu, Mehmet; Güneyisi, Erhan; Mahmood, Swara Fuad; Öz, Hatice Öznur; Mermerdaş, Kasım

    2012-10-15

    Ground granulated blast furnace slag (GGBFS), a by-product from iron industry, was recycled as artificial coarse aggregate through cold bonding pelletization process. The artificial slag aggregates (ASA) replaced partially the natural coarse aggregates in production of self-compacting concrete (SCC). Moreover, as being one of the most widely used mineral admixtures in concrete industry, fly ash (FA) was incorporated as a part of total binder content to impart desired fluidity to SCCs. A total of six concrete mixtures having various ASA replacement levels (0%, 20%, 40%, 60%, and 100%) were designed with a water-to-binder (w/b) ratio of 0.32. Fresh properties of self-compacting concretes (SCC) were observed through slump flow time, flow diameter, V-funnel flow time, and L-box filling height ratio. Compressive strength of hardened SCCs was also determined at 28 days of curing. It was observed that increasing the replacement level of ASA resulted in decrease in the amount of superplasticizer to achieve a constant slump flow diameter. Moreover, passing ability and viscosity of SCC's enhanced with increasing the amount of ASA in the concrete. The maximum compressive strength was achieved for the SCC having 60% ASA replacement. PMID:22951223

  7. Acacia-gelatin microencapsulated liposomes: preparation, stability, and release of acetylsalicylic acid.

    Science.gov (United States)

    Dong, C; Rogers, J A

    1993-01-01

    Liposomes of dipalmitoylphosphatidylcholine (DPPC) containing acetylsalicylic acid (ASA) have been microencapsulated by acacia-gelatin using the complex coacervation technique as a potential oral drug delivery system. The encapsulation efficiency of ASA was unaltered by the microencapsulation process. The stability of the microencapsulated liposomes in sodium cholate solutions at pH 5.6 was much greater than the corresponding liposomes. The optimum composition and conditions for stability and ASA release were 3.0% acacia-gelatin and a 1- to 2-hr formaldehyde hardening time. Approximately 25% ASA was released in the first 6 hr from microencapsulated liposomes at 23 degrees C and the kinetics followed matrix-controlled release (Q varies; is directly proportional to t1/2). At 37 degrees C, this increased to 75% released in 30 min followed by a slow constant release, likely due to lowering of the phase transition temperature of DPPC by the acacia-gelatin to near 37 degrees C. At both temperatures, the release from control liposomes was even more rapid. Hardening times of 4 hr and an acacia-gelatin concentration of 5% resulted in a lower stability of liposomes and a faster release of ASA. It is concluded that under appropriate conditions the microencapsulation of liposomes by acacia-gelatin may increase their potential as an oral drug delivery system. PMID:8430052

  8. Aspirin resistance as cardiovascular risk after kidney transplantation

    Science.gov (United States)

    Sandor, Barbara; Varga, Adam; Rabai, Miklos; Toth, Andras; Papp, Judit; Toth, Kalman; Szakaly, Peter

    2014-05-01

    International surveys have shown that the leading cause of death after kidney transplantation has cardiovascular origin with a prevalence of 35-40%. As a preventive strategy these patients receive aspirin (ASA) therapy, even though their rate of aspirin resistance is still unknown. In our study, platelet aggregation measurements were performed between 2009 and 2012 investigating the laboratory effect of low-dose aspirin (100 mg) treatment using a CARAT TX4 optical aggregometer. ASA therapy was considered clinically effective in case of low ( i.e., below 40%) epinephrine-induced (10 μM) platelet aggregation index. Rate of aspirin resistance, morbidity and mortality data of kidney transplanted patients (n = 255, mean age: 49 ± 12 years) were compared to a patient population with cardio- and cerebrovascular diseases (n = 346, mean age: 52.6 ± 11 years). Rate of aspirin resistance was significantly higher in the renal transplantation group (RT) compared to the positive control group (PC) (35.9% vs. 25.6%, p infarction, hypertension and diabetes mellitus in the RT group (p infarction and stroke in the ASA resistant RT group compared to the RT patients without ASA resistance (p infarction and hypertension was significantly higher in the non-resistant RT group than in the group of PC patients without ASA resistance (p < 0.05). These results may suggest that the elevated rate of aspirin resistance contributes to the high cardiovascular mortality after kidney transplantation.

  9. Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity.

    Science.gov (United States)

    Faria, Joana; Loureiro, Inês; Santarém, Nuno; Macedo-Ribeiro, Sandra; Tavares, Joana; Cordeiro-da-Silva, Anabela

    2016-01-01

    A growing interest in asparagine (Asn) metabolism has currently been observed in cancer and infection fields. Asparagine synthetase (AS) is responsible for the conversion of aspartate into Asn in an ATP-dependent manner, using ammonia or glutamine as a nitrogen source. There are two structurally distinct AS: the strictly ammonia dependent, type A, and the type B, which preferably uses glutamine. Absent in humans and present in trypanosomatids, AS-A was worthy of exploring as a potential drug target candidate. Appealingly, it was reported that AS-A was essential in Leishmania donovani, making it a promising drug target. In the work herein we demonstrate that Leishmania infantum AS-A, similarly to Trypanosoma spp. and L. donovani, is able to use both ammonia and glutamine as nitrogen donors. Moreover, we have successfully generated LiASA null mutants by targeted gene replacement in L. infantum, and these parasites do not display any significant growth or infectivity defect. Indeed, a severe impairment of in vitro growth was only observed when null mutants were cultured in asparagine limiting conditions. Altogether our results demonstrate that despite being important under asparagine limitation, LiAS-A is not essential for parasite survival, growth or infectivity in normal in vitro and in vivo conditions. Therefore we exclude AS-A as a suitable drug target against L. infantum parasites.

  10. Ascorbic Acid and/or 24-Epibrassinolide Trigger Physiological and Biochemical Responses for the Salt Stress Mitigation in Potato (Solanum tuberosum L.

    Directory of Open Access Journals (Sweden)

    Chandrama Prakash Upadhyaya

    2015-12-01

    Full Text Available In the present study, we examined the role of ascorbic acid (AsA, vitamin C and/or 24-epibrassinolide (EBL, an active BR in mitigation of salt-induced stress in potato (Solanum tuberousum L. The 10-d-old plants were exposed to 150 mM NaCl and they were subsequently treated by ASA and/or EBL. The salt stress reduced significantly the plant growth, tuber yield, total chlorophyll and increased proline content and electrolyte leakage in the leaves. Toxic effects induced by salt stress were completely overcome by the combined exogenous application of AsA and EBL. The AsA and/or EBL treatments improved the growth parameters of the salt treated plants, such as shoot length, tuber number and size, fresh and dry mass and other physiological parameters. Our data also indicated that applications of AsA and EBL up-regulated the stress regulating plant hormone such as IAA, IBA and activities of the antioxidant enzymes, such as catalase (CAT, peroxidase (POX, superoxide dismutase (SOD, ascorbate peroxidase (APX and under salt stress.

  11. RESIDUAL PLATELET REACTIVITY DURING THERAPY WITH INHIBITORS OF CYCLOOXIGENASE OR ADENOSINE DIPHOSPHATE RECEPTORS

    Directory of Open Access Journals (Sweden)

    A. A. Lomonosova

    2012-01-01

    Full Text Available Aim. To compare effects of acetylsalicylic acid (ASA and two clopidogrel drugs on residual platelet aggregative reactivity (RPAR. Material and methods. Patients (n=40 with ischemic heart disease aged under 70 years were involved into the crossover study. Clinical examination included questionnaire survey , blood pressure (BP measurement, ECG registration, 24-hour ECG and BP monitoring, determination of blood levels of total cholesterol, high density lipoproteins, triglycerides, transaminases, and creatinine, complete blood cell count, including platelets number and hemoglobin level. Besides evaluation of the platelet aggregation by optical aggregometry was performed initially , after one week ASA treatment and after every next 3 week clopidogrel treatment period.  Results. RPAR during ASA monotherapy was 56.4±0.3%. There were no significant differences in effects of original and generic clopidogrel on RPAR. Сlopidogrel therapy reduced RPAR more significantly (42.2±0.2% than ASA monotherapy did (p=0.0003. Authors proposed definition for high level of RPAR during therapy - it is platelet aggregation more than 46%. Data analysis taking into account this criterion showed that a number of patients with high RPAR was 70 and 30% among patients treated with enterosoluble ASA and clopidogrel, respectively. Conclusion. Study results show that a significant number of patients receiving antiplatelet monotherapy does not achieve the target level of RPAR(<46%. These results may be a rationale for combined therapy in patients of this type.

  12. KONJAC1 and 2 Are Key Factors for GDP-Mannose Generation and Affect l-Ascorbic Acid and Glucomannan Biosynthesis in Arabidopsis.

    Science.gov (United States)

    Sawake, Shota; Tajima, Noriaki; Mortimer, Jenny C; Lao, Jeemeng; Ishikawa, Toshiki; Yu, Xiaolan; Yamanashi, Yukiko; Yoshimi, Yoshihisa; Kawai-Yamada, Maki; Dupree, Paul; Tsumuraya, Yoichi; Kotake, Toshihisa

    2015-12-01

    Humans are unable to synthesize l-ascorbic acid (AsA), yet it is required as a cofactor in many critical biochemical reactions. The majority of human dietary AsA is obtained from plants. In Arabidopsis thaliana, a GDP-mannose pyrophosphorylase (GMPP), VITAMIN C DEFECTIVE1 (VTC1), catalyzes a rate-limiting step in AsA synthesis: the formation of GDP-Man. In this study, we identified two nucleotide sugar pyrophosphorylase-like proteins, KONJAC1 (KJC1) and KJC2, which stimulate the activity of VTC1. The kjc1kjc2 double mutant exhibited severe dwarfism, indicating that KJC proteins are important for growth and development. The kjc1 mutation reduced GMPP activity to 10% of wild-type levels, leading to a 60% reduction in AsA levels. On the contrary, overexpression of KJC1 significantly increased GMPP activity. The kjc1 and kjc1kjc2 mutants also exhibited significantly reduced levels of glucomannan, which is also synthesized from GDP-Man. Recombinant KJC1 and KJC2 enhanced the GMPP activity of recombinant VTC1 in vitro, while KJCs did not show GMPP activity. Yeast two-hybrid assays suggested that the stimulation of GMPP activity occurs via interaction of KJCs with VTC1. These results suggest that KJCs are key factors for the generation of GDP-Man and affect AsA level and glucomannan accumulation through the stimulation of VTC1 GMPP activity.

  13. [Acute ischemic spinal cord disease. Spinal cord infarction. A clinical study and MRI in 8 cases].

    Science.gov (United States)

    Pau Serradell, A

    1994-01-01

    Acute spinal cord infarction (ASCI) occurs infrequently and may have diverse causes. The diagnosis of ASCI, and particularly of an anterior spinal artery syndrome (ASAS) can be confirmed nowadays by MRI, whereas in the past only necropsy confirmation was possible. Pathophysiology and long-term prognosis may be better known at present and treatments more consistent. We present the longitudinal study and clinical features of 8 patients suffering from ASCI. All of them were personally studied and had MRI examinations, often with sequential studies. three groups must be considered: one included 4 cases of ASAS at cervical level, the second 2 cases of ASAS at thoracic level and the third group with infarction of the conus medullaris (ICM), one of them developed during surgical repair of an infrarenal aortic aneurysm. Motor and sensory sequelae were assessed in each case together with possible etiological factors. In conclusion, recovery after ASAS tends to be dependent on the severity of the initial deficit. At cervical level, clinical and morphological findings argue in favour of an extrinsic selective compression of the C7 right radiculo-medullary artery as responsible for the ASA. At thoracic level, the artery preferentially occluded seems to be the sulco-commisural artery as a consequence of disc compression. Finally, an underlying peculiarity of the pattern of arterial supply is a probable predisposing factor for ICM. Generally, the long-term prognosis of ASCI is not necessarily bad. PMID:7801036

  14. Gradient Elution Method for Successive Separation of Common Cations and Hydrophobic Amines using Suppressed Ion Chromatography

    International Nuclear Information System (INIS)

    In mixed waste the separation and sequential determination of alkali, alkaline earth metals mixed with hydrophobic amines represent a challenge analytical problem. The effect of a new mobile phase (amido-sulfonic acid, ASA) on the suppressed ion chromatographic separation of alkali, alkaline earth metals and hydrophobic amines on Dionex Ion Pac CS12A analytical column was investigated. The addition of surface modifier to the eluent appears to provide better interfacial compatibility between the mobile and stationary phase and facilitates the rapid equilibration of analytes. Incorporation of a very low concentration of the additive may also alters the stationary phase surface by creating a fine-tuning and improves the partition characteristics of the analytes. A dramatic and sufficient elution capability of ASA for sequential separation of the analytes was found and rational mechanisms for the separated analytes are proposed. ASA can act as ion-pairing agent resulting in the separation of a wide variety of amines. The new mobile phase (ASA) is proved to have more successful separation over methanesulfonic acid (MSA) even with eluent free solvent. The proposed method shows that a profound particular effect on the separation of aliphatic diamine (ethylenediamine) and organic amine (cyclohexylamine) was achieved in addition to all common cations and amines using isocratic elution of 18 mM of ASA without organic eluent modifier

  15. The Correlation between Sexual Practices and the Development of Antisperm Antibodies

    Directory of Open Access Journals (Sweden)

    Reza Salman Yazdi

    2009-01-01

    Full Text Available Background: Infertility is one of the most common and important subjects in today’s obstetricsand gynecology. Immunological factors such as the presence of antisperm antibodies (ASA arechallenging etiologies for infertility. This study was performed to determine the correlation betweenthe type of sexual practices (oral‚ anal and vaginal during menstruation and the ASA levels insemen and in the sexual partners’ serum.Materials and Methods: In this analytic cross sectional study which was performed in RoyanInstitute between 2005-2007‚ the type of sexual behaviours was determined in 51 couples withprimary or secondary infertility. The ASA level was determined in both sexual partners’ bloodserum and in the semen‚ using the Sperm Mar Test kit.Results: Using statistical analyses‚ there was no significant difference between the types of sexualpractices (anal‚ oral‚ vaginal during menstruation and the prevalence and level of ASA.Conclusion: Based on the results of this study, the prevalence and level of ASA has no significantcorrelation with the types of sexual behaviours (anal‚ oral‚ vaginal during menstruation.

  16. Ethanol increase PGE and thromboxane production in mouse pregnant uterine tissue

    Energy Technology Data Exchange (ETDEWEB)

    Anton, R.F.; Becker, H.C.; Randall, C.L. (Veterans Administration Medical Center, Charleston, SC (USA))

    1990-01-01

    The teratogenic effect of ethanol in the C57BL/6J mouse can be attenuated by pretreatment with aspirin (ASA). One prominent effect of ASA is to inhibit prostaglandin (PGE) and thromboxane (TXB{sub 2}) production. We examined the effect in vivo ethanol exposure on PGE and TXB{sub 2} production in a uterine-embryo tissue sample of C57BL/6J mice either before or after in vivo ASA pretreatment on day 10 of gestation. Ethanol increase both PGE and TXB{sub 2} production by approximately 20%. ASA caused a marked reduction of PGE and TXB{sub 2} in both control and ethanol groups by approximately 80-90%. The mouse strain, gestation time, and study parameters used in this study were the same as in the previously reported ASA attenuation of the teratogenic effect of ethanol. Therefore, the present data add additional support to the hypothesis that prostaglandin and/or thromboxane production may be involved in at least some aspects of fetal alcohol syndrome.

  17. Synthesis and Biological Activities of the Conjugates of Acetylsalicylic Acid with Fungicide%乙酰水杨酸与杀菌剂的藕合物合成及生物活性

    Institute of Scientific and Technical Information of China (English)

    李俊凯; 徐汉虹; 谭堂峰; 朱建永

    2008-01-01

    通过乙酰水杨酸(ASA)分别与噻菌灵、三唑醇和(噁)鄂霉灵3种杀菌剂拼接,合成了未见文献报道的ASA-噻菌灵、ASA-三唑醇、ASA-(噁)霉灵的藕合物,并以未藕合的3种杀菌剂为对照,测定了3种藕合物对水稻纹枯病菌Rhizoctonia solani的室内毒力;以水杨酸(SA)为对照,测定了ASA-??霉灵藕合物对大豆叶片过氧化物酶(POD)活性的影响.结果表明,3种杀菌剂与ASA藕合后,杀菌毒力与藕合前的相当,同时还具有类似SA诱导植物POD活性升高的特性.

  18. Improved aortocoronary bypass patency by low-dose aspirin (100 mg daily). Effects on platelet aggregation and thromboxane formation.

    Science.gov (United States)

    Lorenz, R L; Schacky, C V; Weber, M; Meister, W; Kotzur, J; Reichardt, B; Theisen, K; Weber, P C

    1984-06-01

    Prevention of aortocoronary bypass occlusion by aspirin (ASA, 1 X 100 mg per day) was studied in a prospective double-blind trial of 83 patients. 60 (72%) were randomly allocated to ASA or placebo starting 24 h after operation. 90% of grafts in the ASA group and 68% in the placebo group were patent at four months. At least one anastomosis was occluded in 62% of the patients on placebo and in 27% of those on aspirin. Ventricular arrhythmias increased after surgery in more patients on placebo (12/18) than in patients on ASA (5/17). Platelet thromboxane formation on collagen tested before operation was significantly higher in patients in whom bypass occlusion developed (occlusion: 40 +/- 19, no occlusion: 25 +/- 13 ng/ml). A 100 mg dose of ASA per day effectively blocked platelet thromboxane formation and thromboxane-supported aggregation on collagen and was safe in the postoperative phase. No side effects were reported throughout the trial. The reduced toxicity with full efficacy favours a low and infrequent dosage of aspirin. PMID:6144975

  19. Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications: crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid, and benzylhydroxamic acid.

    Science.gov (United States)

    Singh, Amit K; Singh, Nagendra; Sinha, Mau; Bhushan, Asha; Kaur, Punit; Srinivasan, Alagiri; Sharma, Sujata; Singh, Tej P

    2009-07-24

    The binding and structural studies of bovine lactoperoxidase with three aromatic ligands, acetylsalicylic acid (ASA), salicylhydoxamic acid (SHA), and benzylhydroxamic acid (BHA) show that all the three compounds bind to lactoperoxidase at the substrate binding site on the distal heme side. The binding of ASA occurs without perturbing the position of conserved heme water molecule W-1, whereas both SHA and BHA displace it by the hydroxyl group of their hydroxamic acid moieties. The acetyl group carbonyl oxygen atom of ASA forms a hydrogen bond with W-1, which in turn makes three other hydrogen-bonds, one each with heme iron, His-109 N(epsilon2), and Gln-105 N(epsilon2). In contrast, in the complexes of SHA and BHA, the OH group of hydroxamic acid moiety in both complexes interacts with heme iron directly with Fe-OH distances of 3.0 and 3.2A respectively. The OH is also hydrogen bonded to His-109 N(epsilon2) and Gln-105N(epsilon2). The plane of benzene ring of ASA is inclined at 70.7 degrees from the plane of heme moiety, whereas the aromatic planes of SHA and BHA are nearly parallel to the heme plane with inclinations of 15.7 and 6.2 degrees , respectively. The mode of ASA binding provides the information about the mechanism of action of aromatic substrates, whereas the binding characteristics of SHA and BHA indicate the mode of inhibitor binding.

  20. Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis.

    Science.gov (United States)

    Zhou, Lin; Duan, Xingmei; Zeng, Shi; Men, Ke; Zhang, Xueyan; Yang, Li; Li, Xiang

    2015-01-01

    Natural product curcumin (Cur) and H2S-releasing prodrug SH-aspirin (SH-ASA) are potential anticancer agents with diverse mechanisms, but their clinical application prospects are restricted by hydrophobicity and limited efficiency. In this work, we coencapsulated SH-ASA and Cur into methoxy poly(ethylene glycol)-poly (lactide-coglycolide) (mPEG-PLGA) nanoparticles through a modified oil-in-water single-emulsion solvent evaporation process. The prepared SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles had a mean particle size of 122.3±6.8 nm and were monodispersed (polydispersity index =0.179±0.016) in water, with high drug-loading capacity and stability. Intriguingly, by treating with SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles, obvious synergistic anticancer effects on ES-2 and SKOV3 human ovarian carcinoma cells were observed in vitro, and activation of the mitochondrial apoptosis pathway was indicated. Our results demonstrated that SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles could have potential clinical advantages for the treatment of ovarian cancer.

  1. Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease.

    Science.gov (United States)

    Dhaneshwar, Suneela S

    2014-04-01

    Despite the advent of biological products, such as anti-tumor necrosis factor-α monoclonal antibodies (infliximab and adalimumab), for treatment of moderate to severe cases of inflammatory bowel disease (IBD), most patients depend upon aminosalicylates as the conventional treatment option. In recent years, the increased knowledge of complex pathophysiological processes underlying IBD has resulted in development of a number of newer pharmaceutical agents like low-molecular-weight heparin, omega-3 fatty acids, probiotics and innovative formulations such as high-dose, once-daily multi-matrix mesalamine, which are designed to minimize the inflammatory process through inhibition of different targets. Optimization of delivery of existing drugs to the colon using the prodrug approach is another attractive alternative that has been utilized and commercialized for 5-aminosalicylic acid (ASA) in the form of sulfasalazine, balsalazide, olsalazine and ipsalazine, but rarely for its positional isomer 4-ASA - a well-established antitubercular drug that is twice as potent as 5-ASA against IBD, and more specifically, ulcerative colitis. The present review focuses on the complete profile of 4-ASA and its advantages over 5-ASA and colon-targeting prodrugs reported so far for the management of IBD. The review also emphasizes the need for reappraisal of this promising but unexplored entity as a potential treatment option for IBD. PMID:24707139

  2. Kwas acetylosalicylowy i jego zastosowanie w profilaktyce chorób u kobiet po menopauzie

    Directory of Open Access Journals (Sweden)

    Ireneusz Połać

    2011-02-01

    Full Text Available Acetylsalicylic acid (ASA is a simple chemical compound belonging to a group of nonsteroidal antiinflammatorydrugs (NSAIDs. The mechanism of acetylsalicylic acid is based on the inhibition of cyclooxygenase(COX. That enzyme is responsible for the biosynthesis of cyclic prostanoids, i.e. prostaglandins (D2, E2, F2, I2,thromboxane A2 (TXA2 and prostacyclin. For this reason ASA is one of the most popular anti-inflammatorydrugs present on the pharmaceutical market. Due to its ability to inhibit the synthesis of TXA2 (moleculescapable of platelet activation ASA is effective in the prevention of cardiovascular diseases such as ischemicheart disease. Clinical trials confirm the efficacy of aspirin in the prevention of cardiovascular diseases inpostmenopausal women. In some cases ASA is unable to inhibit platelet activation. This phenomenon iscalled aspirin resistance. Acetylsalicylic acid can also inhibit aromatase activity, therefore it may be used inthe prevention of breast cancer. Many clinical trials confirm that acetylsalicylic acid reduces the risk of breastcancer in postmenopausal women. Use of ASA may also increase bone mineral density (BMD. This articledescribes the mechanism of action and pharmacokinetics of the acetylsalicylic acid as well as clinical trialsconducted on postmenopausal women.

  3. Soil! Get the Scoop - The Soil Science Society of America's International Year of Soils Campaign

    Science.gov (United States)

    Lindbo, David L.; Hopmans, Jan; Olson, Carolyn; Fisk, Susan; Chapman, Susan; van Es, Harold

    2015-04-01

    Soils are a finite natural resource and are nonrenewable on a human time scale. Soils are the foundation for food, animal feed, fuel and natural fiber production, the supply of clean water, nutrient cycling and a range of ecosystem functions. The area of fertile soils covering the world's surface is limited and increasingly subject to degradation, poor management and loss to urbanization. Increased awareness of the life-supporting functions of soil is called for if this trend is to be reversed and so enable the levels of food production necessary to meet the demands of population levels predicted for 2050. The Soil Science Society of America is coordinating with the Global Soil Partnership and other organizations around the world to celebrate the 2015 International Year of Soils and raise awareness and promote the sustainability of our limited soil resources. We all have a valuable role in communicating vital information on soils, a life sustaining natural resource. Therefore, we will provide resources to learn about soils and help us tell the story of soils. We will promote IYS on social media by sharing our posts from Facebook and Twitter. Additionally SSSA developed 12 monthly themes that reflect the diverse value of soils to our natural environment and society. Each month has information on the theme, a lesson plan, and other outreach activities. All information is available on a dedicated website www.soil.org/IYS. The site will be updated constantly throughout the year.

  4. A Coral-based Reconstruction of Sea Surface Salinity at Sabine Bank, Vanuatu from 2007 to 1843 CE

    Science.gov (United States)

    Gorman, M. K.; Quinn, T. M.; Taylor, F. W.; Dunn, E. M.; Cabioch, G.; Ballu, V.; Maes, C.; Austin, J. A.; Saustrup, S.; Pelletier, B.

    2011-12-01

    We present a reconstruction of sea surface salinity (SSS) derived from a coral δ18O time series extending from 2007-1843 CE at Sabine Bank, Vanuatu (SBV, 166.04° E, 15.94°S). This reconstruction is significant because instrumental records of SSS are rare in time and space, yet the SSS response to the El Niño Southern Oscillation (ENSO) forcing is large in many regions of the tropical oceans. There is a strong positive relationship between sea surface temperature anomalies (SSTA) in the central Pacific (Niño 3.4 region; canonical ENSO signal) and six month lagged sea surface salinity anomalies (SSSA, data from Delcroix et al., 2011) at SBV, which establishes a dynamical link between surface ocean variability at SBV and ENSO variability. We calculate a coral δ18O anomaly time series and note that there is a strong correlation between it and instrumental SSS variations over the period 1970-2007 (r = 0.70, p 0.5 psu) pre-1970 corresponding to strong ENSO warm phase events recorded in the SST instrumental record and historical ENSO record (i.e. 1941-42, 1918-19, 1877-78), and an overall freshening trend, demonstrating the ability of our reconstructed dataset to capture interannual variability as well as long-term trends in SSS at Vanuatu.

  5. Computing Beyond the Church-Turing Limit

    Science.gov (United States)

    Jones, Robert

    2009-05-01

    Dershowitz and Gurevich claim to have proven the Church-Turing theorem starting from a set of 4 reasonable postulates. (Bulletin of Symbolic Logic, vol. 14, num. 3, Sept. 2008, pg. 299) But their postulate II assumes fixed vocabulary. Humans, however, change their vocabulary words (and concepts) over time. My Asa H artificial intelligence also changes its vocabulary. (Trans. of the Kansas Acad. of Sci., vol. 109, no. 3/4, pg 159, 2006, www.bioone.org/archive/0022- 8443/109/3/pdf/i0022-8443-109-3-159.pdf) Their postulate I excludes nondeterministic transitions between states. I don't know how often humans flip a coin but my Asa H does employ random transitions under certain circumstances. Perhaps humans and Asa H go beyond the Church-Turing limit. (Trans. Kansas Acad. of Sci., 108, 3/4, pg. 169, 2005)

  6. Blødningskomplikationer ved behandling med clopidogrel og acetylsalicylsyre efter akut koronart syndrom

    DEFF Research Database (Denmark)

    Kjær, Janus; Larsen, Christian Hastrup; Poulsen, Tina Svenstrup;

    2006-01-01

    INTRODUCTION: The Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study showed that patients with unstable angina pectoris (UAP) and non-ST-elevation myocardial infarction (NSTEMI) benefit from combined therapy with acetylsalicylic acid (ASA) and clopidogrel. However, only...... with the patients treated with clopidogrel and ASA in the CURE study, we also found a three times greater risk of major bleeding in period 2. In particular, patients over 70 years of age and patients undergoing bypass surgery were at heightened risk. The incidence of the primary clinical end point was higher...... in both period 1 and period 2 than in the CURE study. CONCLUSION: Our study demonstrates an increased risk of major bleeding in unselected patients receiving combination therapy with ASA and clopidogrel after UAP or NSTEMI. Major bleeding complications most frequently occur in patients above 70 years...

  7. Un avenir incertain pour les associations syndicales autorisées d’irrigation

    OpenAIRE

    S. Loubier; P. Garin

    2013-01-01

    Cet article aborde les conditions d’une gestion durable des périmètres irrigués par des associations d’usagers, à travers l’analyse des conditions de la longévité des associations syndicales autorisées (ASA) françaises. Nous présentons les cinq principes forts de leur cadre juridique et réglementaire ancien, nés d’une volonté de maîtrise du devenir des ASA par la puissance publique. Nous illustrons également comment ces principes permettent aux ASA de se conformer à la plupart des conditions ...

  8. Decontamination of laryngoscopes in The Netherlands.

    Science.gov (United States)

    Bucx, M J; Dankert, J; Beenhakker, M M; Harrison, T E

    2001-01-01

    In this study the decontamination procedures of laryngoscopes in Dutch hospitals are described, based on a structured telephone questionnaire. There were substantial differences between decontamination procedures in Dutch hospitals and the standards of the APIC (Association of Professionals in Infection Control and Epidemiology), CDC (Centers of Disease Control) and ASA (American Society of Anesthesiology) were met in full in 19.4% of the hospitals. The standards of manual decontamination, used in 78% of the 139 hospitals, were particularly disappointing; manual cleaning was considered inadequate in 22.9% of these hospitals and manual disinfection did not meet the standards of the APIC, CDC or ASA in any of these hospitals. Decontamination by instrument cleaning machines as a standard procedure was used in 30 (22%) hospitals. In three of these hospitals the blades were subsequently sterilized. We suggest adherence to the infection control guidelines of the CDC, APIC and ASA, until the safety of less conservative infection control practices are demonstrated. PMID:11575419

  9. The discriminative value of inflammatory back pain in patients with persistent low back pain

    DEFF Research Database (Denmark)

    Arnbak, Bodil Al-Mashhadi; Hendricks, Oliver; Hørslev-Petersen, Kim;

    2016-01-01

    OBJECTIVES: To estimate the prevalence of inflammatory back pain (IBP) characteristics and analyse the discriminative value of IBP relative to axial spondyloarthritis (SpA) according to the Assessment of SpondyloArthritis international Society (ASAS) criteria. METHOD: Patients who had low back pain...... value was low, as IBP could not differentiate patients with SpA according to ASAS criteria from patients with other causes of back pain....... the pain characteristics included in the Calin, Berlin, and ASAS IBP definitions. RESULTS: Of the 759 included patients, 99% [95% confidence interval (CI) 98-100] had at least one IBP characteristic. The prevalence of the single IBP characteristics ranged from 10% (95% CI 7-12) for 'pain worst...

  10. Management of Blood Pressure in Patients with Ischemic Stroke or Transient Ischemic Attack%缺血性卒中及短暂性脑缺血发作患者的血压管理

    Institute of Scientific and Technical Information of China (English)

    耿昱; 徐安定; 高山

    2011-01-01

    @@ 与美国心脏协会(American Heart Association,AHA)/美国卒中协会(American Stroke Association,ASA)2006年缺血性卒中/短暂性脑缺血发作(ttansient ischemic Attack,TIA)二级预防指南类似[1],AHA/ASA2011版缺血性卒中/TIA二级预防指南(ASA2011二级预防指南)南继续将高血压列在缺血性卒中/TIA危险因素控制的首位,足见降压治疗的重要性[2].

  11. ACOUSTICAL STANDARDS NEWS.

    Science.gov (United States)

    Stremmel, Neil; Struck, Christopher J

    2016-07-01

    American National Standards (ANSI Standards) developed by Accredited Standards Committees S1, S2, S3, S3/SC 1, and S12 in the areas of acoustics, mechanical vibration and shock, bioacoustics, animal bioacoustics, and noise, respectively, are published by the Acoustical Society of America (ASA). In addition to these standards, ASA publishes a catalog of Acoustical American National Standards. To receive a copy of the latest Standards catalog, please contact Neil Stremmel.Comments are welcomed on all material in Acoustical Standards News.This Acoustical Standards News section in JASA, as well as the National Catalog of Acoustical Standards and other information on the Standards Program of the Acoustical Society of America, are available via the ASA home page: http://acousticalsociety.org. PMID:27475185

  12. Quality and antioxidant properties on sweet cherries as affected by preharvest salicylic and acetylsalicylic acids treatments.

    Science.gov (United States)

    Giménez, María José; Valverde, Juan Miguel; Valero, Daniel; Guillén, Fabián; Martínez-Romero, Domingo; Serrano, María; Castillo, Salvador

    2014-10-01

    The effects of salicylic acid (SA) or acetylsalicylic acid (ASA) treatments during on-tree cherry growth and ripening on fruit quality attributes, especially those related with the content on bioactive compounds and antioxidant activity were analysed in this research. For this purpose, two sweet cherry cultivars, 'Sweet Heart' and 'Sweet Late', were used and SA or ASA treatments, at 0.5, 1.0 and 2.0mM concentrations, were applied at three key points of fruit development (pit hardening, initial colour changes and onset of ripening). These treatments increased fruit weight and ameliorated quality attributes at commercial harvest, and led to cherries with higher concentration in total phenolics and in total anthocyanins, as well as higher antioxidant activity, in both hydrophilic and lipophilic fractions. Thus, preharvest treatments with SA or ASA could be promising tools to improve sweet cherry quality and health beneficial effects for consumers. PMID:24799232

  13. Non-anesthesiologist administration of propofol for gastrointestinal endoscopy

    DEFF Research Database (Denmark)

    Dumonceau, Jean-Marc; Riphaus, Andrea; Schreiber, Florian;

    2015-01-01

    driving, drinking alcohol, operating heavy machinery, or engaging in legally binding decisions. Advice should be provided verbally and in written form to the patient, including a 24-hour contact phone number (strong recommendation, low quality evidence). 10 For patients of ASA classes 1 - 2 who have...... recommendation, low quality evidence). 9 Minimum discharge criteria should be fulfilled before discharging a patient. We recommend that patients who have received combined regimens, and all patients of ASA class > 2, should upon discharge be accompanied by a responsible person and refrain for 24 hours from......-anesthesiologist administration of propofol (NAAP) (strong recommendation, moderate quality evidence). 2 We suggest primary involvement of an anesthesiologist in patients of ASA class ≥ 3, with a Mallampati's class ≥ 3 or other conditions that put them at risk of airway obstruction (e. g. pharyngolaryngeal tumors), in patients...

  14. Classroom Materials from the Acoustical Society of America

    Science.gov (United States)

    Adams, W. K.; Clark, A.; Schneider, K.

    2013-09-01

    As part of the new education initiatives of the Acoustical Society of America (ASA), an activity kit for teachers that includes a variety of lessons addressing acoustics for a range of students (K-12) has been created. The "Sound and Music Activity Kit" is free to K-12 teachers. It includes materials sufficient to teach a class of 30 students plus a USB thumb drive containing 47 research-based, interactive, student-tested lessons, laboratory exercises, several assessments, and video clips of a class using the materials. ASA has also partnered with both the Optical Society of America (OSA) and the American Association of Physics Teachers. AAPT Physics Teaching Resource Agents (PTRA) have reviewed the lessons along with members of the ASA Teacher Activity Kit Committee. Topics include basic learning goals for teaching the physics of sound with examples and applications relating to medical imaging, animal bioacoustics, physical and psychological acoustics, speech, audiology, and architectural acoustics.

  15. Using Capillary Electrophoresis to Determine the Purity of Acetylsalicylic Acid Synthesized in the Undergraduate Laboratory

    Science.gov (United States)

    Welder, Frank; Colyer, Christa L.

    2001-11-01

    Capillary electrophoresis (CE), although a powerful analytical tool, has found only limited application in undergraduate laboratory study. In an effort to expose freshman and sophomore chemistry students to this technique, thereby giving them practical instrumental experience early in their careers, we propose to use CE in the analysis of student-synthesized acetylsalicylic acid (ASA). The synthesis of ASA from salicylic acid (SA) is a routine undergraduate laboratory, although students rarely have the opportunity to test the purity of their product. The CE method described herein provides students with a method to test purity and yield of their product and to determine the effect of aging on their sample. CE can accomplish this in a short period of time, with minimal disruption to the regular laboratory curriculum. Optimized separation conditions, limits of detection, and linear range for ASA and SA are also given.

  16. Comparative gastrointestinal blood loss associated with placebo, aspirin, and nabumetone as assessed by radiochromium (/sup 51/Cr)

    Energy Technology Data Exchange (ETDEWEB)

    Lussier, A.; Davis, A.; Lussier, Y.; Lebel, E.

    1989-03-01

    Nabumetone differs from most other nonsteroidal anti-inflammatory drugs. It is presented to the gut as a nonacidic prodrug, and is metabolized to its active form after absorption. Studies in animals and humans suggest it is less irritating to the gastrointestinal mucosa. This study compared the gastrointestinal microbleeding induced by nabumetone to aspirin (acetylsalicylic acid, ASA), and placebo in a double blind parallel study using chromium /sup 51/Cr labelled red cells to quantitate fecal blood loss (FBL) in healthy volunteers. Thirty subjects were randomized to treatment with nabumetone (2000 mg), ASA (3.6 g) or placebo for 21 days following a 7 day placebo period. Six subjects served as untreated controls. FBL in nabumetone treated subjects was not significantly different to placebo or untreated subjects. In contrast, ASA-treated subjects exhibited significantly increased FBL than the other 3 groups (P less than .0001).

  17. Non-linear Ultrasound Imaging

    DEFF Research Database (Denmark)

    Du, Yigang

    without iteration steps. The ASA is implemented in combination with Field II and extended to simulate the pulsed ultrasound fields. The simulated results from a linear array transducer are made by the ASA based on Field II, and by a released non-linear simulation program- Abersim, respectively....... The calculation speed of the ASA is increased approximately by a factor of 140. For the second harmonic point spread function the error of the full width is 1.5% at -6 dB and 6.4% at -12 dB compared to Abersim. To further investigate the linear and non-linear ultrasound fields, hydrophone measurements.......3% relative to the measurement from a 1 inch diameter transducer. A preliminary study for harmonic imaging using synthetic aperture sequential beamforming (SASB) has been demonstrated. A wire phantom underwater measurement is made by an experimental synthetic aperture real-time ultrasound scanner (SARUS...

  18. Angular Spectrum Simulation of Pulsed Ultrasound Fields

    DEFF Research Database (Denmark)

    Du, Yigang; Jensen, Henrik; Jensen, Jørgen Arendt

    2009-01-01

    The optimization of non-linear ultrasound imaging should in a first step be based on simulation, as this makes parameter studies considerably easier than making transducer prototypes. Such a simulation program should be capable of simulating non-linear pulsed fields for arbitrary transducer...... geometries for any kind of focusing and apodization. The Angular Spectrum Approach (ASA) is capable of simulating monochromatic non-linear acoustic wave propagation. However, for ultrasound imaging the time response of each specific point in space is required, and a pulsed ASA simulation with multi temporal....... The RMS error of the pulses for all points in the simulated plane is 10.9%. The good agreement between ASA and Field II simulation for the pulsed ultrasound fields obtained in this paper makes it possible to expand Field II to non-linear pulsed fields....

  19. Palomuurien IPv6-migraatio

    OpenAIRE

    Leinonen, Riku

    2011-01-01

    Tämän työn tarkoituksena on ollut tutkia Cisco ASA -palomuurien IPv6-ominaisuuksia ja sitä, mitä pitää ottaa huomioon IPv6-osoitteisiin siirtyessä, erityisesti Cisco ASA 5510 -palomuureissa. Työssä selvitettiin, miten saatiin käytössä olevaan IPv4-palomuuriin lisättyä IPv6-liikenne ja mitä eri IPv6-tunneleita voitiin toteuttaa eri Cisco ASA –käyttöjärjestelmäversioilla. Työssä selvitettiin myös miten natiivi IPv6-palomuuri liitettiin verkkoon. Työ on tehty Optimiratkaisut Oy:n toimeksiantona ...

  20. Trading in Risk Dimensions (TRD)

    CERN Document Server

    Ingber, Lester

    2007-01-01

    Previous work, mostly published, developed two-shell recursive trading systems. An inner-shell of Canonical Momenta Indicators (CMI) is adaptively fit to incoming market data. A parameterized trading-rule outer-shell uses the global optimization code Adaptive Simulated Annealing (ASA) to fit the trading system to historical data. A simple fitting algorithm, usually not requiring ASA, is used for the inner-shell fit. An additional risk-management middle-shell has been added to create a three-shell recursive optimization/sampling/fitting algorithm. Portfolio-level distributions of copula-transformed multivariate distributions (with constituent markets possessing different marginal distributions in returns space) are generated by Monte Carlo samplings. ASA is used to importance-sample weightings of these markets. The core code, Trading in Risk Dimensions (TRD), processes Training and Testing trading systems on historical data, and consistently interacts with RealTime trading platforms at minute resolutions, but ...

  1. Synthesis of azo derivatives of 4-aminosalicylic acid

    Institute of Scientific and Technical Information of China (English)

    Zheng Bao Zhao; Hui Xia Zheng; Yuan Gui Wei; Jiang Liu

    2007-01-01

    For searching a better 4-aminosalicylic acid derivative with higher activity and less side effects against the inflammatory bowel disease, 4-aminosalicylic acid (4-ASA) was protected by benzyloxycarbonyl and acetyl, respectively.The resultant was hydrogenized to remove protective group of amino group, then the product was reacted with NaNO2 to give diazonium salt, which was conjugated with salicylic acid, hydroxybenzene, N-salicyloyl glycine acid to get azo derivatives of 4-ASA.The azo derivatives were hydrolyzed under the alkaline condition to get the target products.All compounds were characterized by FT-IR, 1H NMR, 13C NMR spectra in details.New derivatives of 4-ASA were characterized.The synthetic route was reasonable and feasible.

  2. Sulfatide recognition by colonization factor antigen CS6 from enterotoxigenic Escherichia coli.

    Directory of Open Access Journals (Sweden)

    Lena Jansson

    Full Text Available The first step in the pathogenesis of enterotoxigenic Escherichia coli (ETEC infections is adhesion of the bacterium to the small intestinal epithelium. Adhesion of ETEC is mediated by a number of antigenically distinct colonization factors, and among these, one of the most commonly detected is the non-fimbrial adhesin coli surface antigen 6 (CS6. The potential carbohydrate recognition by CS6 was investigated by binding of recombinant CS6-expressing E. coli and purified CS6 protein to a large number of variant glycosphingolipids separated on thin-layer chromatograms. Thereby, a highly specific binding of the CS6-expressing E. coli, and the purified CS6 protein, to sulfatide (SO(3-3Galbeta1Cer was obtained. The binding of the CS6 protein and CS6-expressing bacteria to sulfatide was inhibited by dextran sulfate, but not by dextran, heparin, galactose 4-sulfate or galactose 6-sulfate. When using recombinantly expressed and purified CssA and CssB subunits of the CS6 complex, sulfatide binding was obtained with the CssB subunit, demonstrating that the glycosphingolipid binding capacity of CS6 resides within this subunit. CS6-binding sulfatide was present in the small intestine of species susceptible to CS6-mediated infection, e.g. humans and rabbits, but lacking in species not affected by CS6 ETEC, e.g. mice. The ability of CS6-expressing ETEC to adhere to sulfatide in target small intestinal epithelium may thus contribute to virulence.

  3. Fabrication of fluorescent chitosan-containing microcapsules

    Directory of Open Access Journals (Sweden)

    Zhang R.

    2013-08-01

    Full Text Available Intense emission peaks of Eu(DBM3Phen (DBM and Phen are dibenzoylmethane and 1,10-phenanthroline, respectively in the microcapsules containing molecules of quaternary ammonium chitosan (QACS and sodium alginate are observed. The microcapsules are assembled by using CaCO3 particles as template cores by the layer-by-layer (LbL technique. Observation of microcapsules by the fluorescence mode and the transmission mode in the confocal laser scanning microscopy shows that the microcapsules are intact after core decomposition. Fluorescence under ultraviolet irradiation comes directly from the Eu(DBM3Phen. Homogeneous assembly of Eu(DBM3Phen can be deduced due to the homogeneous fluorescence of the microcapsules in the fluorescence micrographs. The microcapsules show adherence to solid substrates due to large quantities of hydroxyl groups of QACS. AFM measurements of dried hollow microcapsules with only 4 bilayers of (CS/SA fabricated with Eu(DBM3Phen show the intact shell with a thickness of 3.0 nm. Regarding the biocompatible natural polysaccharides and the intense fluorescence emission, the microcapsules in this work might be of great importance in potential application in drug delivery and bioassay.

  4. Lipoic acid and redox status in barley plants subjected to salinity and elevated CO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Lopez, U.; Robredo, A.; Mena-Petite, A.; Munoz-Rueda, A. (Univ. del Pais Vasco/EHU, Dept. de Biologia Vegetal y Ecologia, Bilbao (Spain)); Lacuesta, M. (Univ. del Pais Vasco/EHU, Dept. de Biologia Vegetal y Ecologia, Vitoria-Gasteiz (Spain)); Sgherri, C.; Navari-Izzo, F. (Univ. di Pisa, Dipartimento di Chimica e Biotecnologie Agrarie, Pisa (Italy))

    2010-02-15

    Future environmental conditions will include elevated concentrations of salt in the soil and an elevated concentration of CO{sub 2}in the atmosphere. Because these environmental changes will likely affect reactive oxygen species (ROS) formation and cellular antioxidant metabolism in opposite ways, we analyzed changes in cellular H{sub 2}O{sub 2} and non-enzymatic antioxidant metabolite [lipoic acid (LA), ascorbate (ASA), glutathione (GSH)] content induced by salt stress (0, 80, 160 or 240 mM NaCl) under ambient (350 mumol mol-1) or elevated (700 mumol mol-1) CO{sub 2}concentrations in two barley cultivars (Hordeum vulgare L.) that differ in sensitivity to salinity (cv. Alpha is more sensitive than cv. Iranis). Under non-salinized conditions, elevated CO{sub 2}increased LA content, while ASA and GSH content decreased. Under salinized conditions and ambient CO{sub 2}, ASA increased, while GSH and LA decreased. At 240 mM NaCl, H{sub 2}O{sub 2} increased in Alpha and decreased in Iranis. When salt stress was imposed at elevated CO{sub 2}, less oxidative stress and lower increases in ASA were detected, while LA was constitutively higher. The decrease in oxidative stress could have been because of less ROS formation or to a higher constitutive LA level, which might have improved regulation of ASA and GSH reductions. Iranis had a greater capacity to synthesize ASA de novo and had higher constitutive LA content than did Alpha. Therefore, we conclude that elevated CO{sub 2}protects barley cultivars against oxidative damage. However, the magnitude of the positive effect is cultivar specific. (author)

  5. An Energy Aware Adaptive Sampling Algorithm for Energy Harvesting WSN with Energy Hungry Sensors

    Science.gov (United States)

    Srbinovski, Bruno; Magno, Michele; Edwards-Murphy, Fiona; Pakrashi, Vikram; Popovici, Emanuel

    2016-01-01

    Wireless sensor nodes have a limited power budget, though they are often expected to be functional in the field once deployed for extended periods of time. Therefore, minimization of energy consumption and energy harvesting technology in Wireless Sensor Networks (WSN) are key tools for maximizing network lifetime, and achieving self-sustainability. This paper proposes an energy aware Adaptive Sampling Algorithm (ASA) for WSN with power hungry sensors and harvesting capabilities, an energy management technique that can be implemented on any WSN platform with enough processing power to execute the proposed algorithm. An existing state-of-the-art ASA developed for wireless sensor networks with power hungry sensors is optimized and enhanced to adapt the sampling frequency according to the available energy of the node. The proposed algorithm is evaluated using two in-field testbeds that are supplied by two different energy harvesting sources (solar and wind). Simulation and comparison between the state-of-the-art ASA and the proposed energy aware ASA (EASA) in terms of energy durability are carried out using in-field measured harvested energy (using both wind and solar sources) and power hungry sensors (ultrasonic wind sensor and gas sensors). The simulation results demonstrate that using ASA in combination with an energy aware function on the nodes can drastically increase the lifetime of a WSN node and enable self-sustainability. In fact, the proposed EASA in conjunction with energy harvesting capability can lead towards perpetual WSN operation and significantly outperform the state-of-the-art ASA. PMID:27043559

  6. Onyx injection by direct puncture for the treatment of hypervascular spinal metastases close to the anterior spinal artery: initial experience.

    Science.gov (United States)

    Clarençon, Frédéric; Di Maria, Federico; Cormier, Evelyne; Sourour, Nader-Antoine; Enkaoua, Eric; Sailhan, Frédéric; Iosif, Christina; Le Jean, Lise; Chiras, Jacques

    2013-06-01

    Presurgical devascularization of hypervascular spinal metastases has been shown to be effective in preventing major blood loss during open surgery. Most often, embolization can be performed using polyvinyl alcohol (PVA) microparticles. However, in some cases, the close relationship between the feeders of the metastases and the feeders of the anterior spinal artery (ASA) poses a risk of spinal cord ischemia when PVA microparticle embolization is performed. The authors present their early experience in the treatment of spinal metastases close to the ASA; in 2 cases they injected Onyx-18, by direct puncture, into hypervascular posterior arch spinal metastases situated close to the ASA. Two women, one 36 and the other 55 years of age, who presented with spinal lesions (at the posterior arch of C-4 and T-6, respectively) from thyroid and a kidney tumors, were sent to the authors' department to undergo presurgical embolization. After having performed a complete spinal digital subtraction angiography study, a regular angiography catheter was positioned at the ostium of the artery that mainly supplied the lesion. Then, with the patient in the left lateral decubitus position, direct puncture with 18-gauge needles of the lesion was performed using roadmap guidance. Onyx-18 was injected through the needles under biplanar fluoroscopy. Satisfactory devascularization of the lesions was obtained; the ASA remained patent in both cases. The metastases were surgically removed in both cases within the 48 hours after the embolization and major blood loss did not occur. Presurgical devascularization of hypervascular spinal metastases close the ASA by direct puncture with Onyx-18 seems to be an effective technique and appears to be safe in terms of the preserving the ASA's patency. PMID:23600580

  7. An Energy Aware Adaptive Sampling Algorithm for Energy Harvesting WSN with Energy Hungry Sensors

    Directory of Open Access Journals (Sweden)

    Bruno Srbinovski

    2016-03-01

    Full Text Available Wireless sensor nodes have a limited power budget, though they are often expected to be functional in the field once deployed for extended periods of time. Therefore, minimization of energy consumption and energy harvesting technology in Wireless Sensor Networks (WSN are key tools for maximizing network lifetime, and achieving self-sustainability. This paper proposes an energy aware Adaptive Sampling Algorithm (ASA for WSN with power hungry sensors and harvesting capabilities, an energy management technique that can be implemented on any WSN platform with enough processing power to execute the proposed algorithm. An existing state-of-the-art ASA developed for wireless sensor networks with power hungry sensors is optimized and enhanced to adapt the sampling frequency according to the available energy of the node. The proposed algorithm is evaluated using two in-field testbeds that are supplied by two different energy harvesting sources (solar and wind. Simulation and comparison between the state-of-the-art ASA and the proposed energy aware ASA (EASA in terms of energy durability are carried out using in-field measured harvested energy (using both wind and solar sources and power hungry sensors (ultrasonic wind sensor and gas sensors. The simulation results demonstrate that using ASA in combination with an energy aware function on the nodes can drastically increase the lifetime of a WSN node and enable self-sustainability. In fact, the proposed EASA in conjunction with energy harvesting capability can lead towards perpetual WSN operation and significantly outperform the state-of-the-art ASA.

  8. CONSTRUCTION OF A CALIBRATED PROBABILISTIC CLASSIFICATION CATALOG: APPLICATION TO 50k VARIABLE SOURCES IN THE ALL-SKY AUTOMATED SURVEY

    International Nuclear Information System (INIS)

    With growing data volumes from synoptic surveys, astronomers necessarily must become more abstracted from the discovery and introspection processes. Given the scarcity of follow-up resources, there is a particularly sharp onus on the frameworks that replace these human roles to provide accurate and well-calibrated probabilistic classification catalogs. Such catalogs inform the subsequent follow-up, allowing consumers to optimize the selection of specific sources for further study and permitting rigorous treatment of classification purities and efficiencies for population studies. Here, we describe a process to produce a probabilistic classification catalog of variability with machine learning from a multi-epoch photometric survey. In addition to producing accurate classifications, we show how to estimate calibrated class probabilities and motivate the importance of probability calibration. We also introduce a methodology for feature-based anomaly detection, which allows discovery of objects in the survey that do not fit within the predefined class taxonomy. Finally, we apply these methods to sources observed by the All-Sky Automated Survey (ASAS), and release the Machine-learned ASAS Classification Catalog (MACC), a 28 class probabilistic classification catalog of 50,124 ASAS sources in the ASAS Catalog of Variable Stars. We estimate that MACC achieves a sub-20% classification error rate and demonstrate that the class posterior probabilities are reasonably calibrated. MACC classifications compare favorably to the classifications of several previous domain-specific ASAS papers and to the ASAS Catalog of Variable Stars, which had classified only 24% of those sources into one of 12 science classes.

  9. CONSTRUCTION OF A CALIBRATED PROBABILISTIC CLASSIFICATION CATALOG: APPLICATION TO 50k VARIABLE SOURCES IN THE ALL-SKY AUTOMATED SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Richards, Joseph W.; Starr, Dan L.; Miller, Adam A.; Bloom, Joshua S.; Brink, Henrik; Crellin-Quick, Arien [Astronomy Department, University of California, Berkeley, CA 94720-3411 (United States); Butler, Nathaniel R., E-mail: jwrichar@stat.berkeley.edu [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287 (United States)

    2012-12-15

    With growing data volumes from synoptic surveys, astronomers necessarily must become more abstracted from the discovery and introspection processes. Given the scarcity of follow-up resources, there is a particularly sharp onus on the frameworks that replace these human roles to provide accurate and well-calibrated probabilistic classification catalogs. Such catalogs inform the subsequent follow-up, allowing consumers to optimize the selection of specific sources for further study and permitting rigorous treatment of classification purities and efficiencies for population studies. Here, we describe a process to produce a probabilistic classification catalog of variability with machine learning from a multi-epoch photometric survey. In addition to producing accurate classifications, we show how to estimate calibrated class probabilities and motivate the importance of probability calibration. We also introduce a methodology for feature-based anomaly detection, which allows discovery of objects in the survey that do not fit within the predefined class taxonomy. Finally, we apply these methods to sources observed by the All-Sky Automated Survey (ASAS), and release the Machine-learned ASAS Classification Catalog (MACC), a 28 class probabilistic classification catalog of 50,124 ASAS sources in the ASAS Catalog of Variable Stars. We estimate that MACC achieves a sub-20% classification error rate and demonstrate that the class posterior probabilities are reasonably calibrated. MACC classifications compare favorably to the classifications of several previous domain-specific ASAS papers and to the ASAS Catalog of Variable Stars, which had classified only 24% of those sources into one of 12 science classes.

  10. Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.

    Science.gov (United States)

    Yang, H; Pellegrini, L; Napolitano, A; Giorgi, C; Jube, S; Preti, A; Jennings, C J; De Marchis, F; Flores, E G; Larson, D; Pagano, I; Tanji, M; Powers, A; Kanodia, S; Gaudino, G; Pastorino, S; Pass, H I; Pinton, P; Bianchi, M E; Carbone, M

    2015-01-01

    High-mobility group box 1 (HMGB1) is an inflammatory molecule that has a critical role in the initiation and progression of malignant mesothelioma (MM). Aspirin (acetylsalicylic acid, ASA) is the most widely used nonsteroidal anti-inflammatory drug that reduces the incidence, metastatic potential and mortality of many inflammation-induced cancers. We hypothesized that ASA may exert anticancer properties in MM by abrogating the carcinogenic effects of HMGB1. Using HMGB1-secreting and -non-secreting human MM cell lines, we determined whether aspirin inhibited the hallmarks of HMGB1-induced MM cell growth in vitro and in vivo. Our data demonstrated that ASA and its metabolite, salicylic acid (SA), inhibit motility, migration, invasion and anchorage-independent colony formation of MM cells via a novel HMGB1-mediated mechanism. ASA/SA, at serum concentrations comparable to those achieved in humans taking therapeutic doses of aspirin, and BoxA, a specific inhibitor of HMGB1, markedly reduced MM growth in xenograft mice and significantly improved survival of treated animals. The effects of ASA and BoxA were cyclooxygenase-2 independent and were not additive, consistent with both acting via inhibition of HMGB1 activity. Our findings provide a rationale for the well documented, yet poorly understood antitumorigenic activity of aspirin, which we show proceeds via HMGB1 inhibition. Moreover, the use of BoxA appears to allow a more efficient HMGB1 targeting while eluding the known gastrointestinal side effects of ASA. Our findings are directly relevant to MM. Given the emerging importance of HMGB1 and its tumor-promoting functions in many cancer types, and of aspirin in cancer prevention and therapy, our investigation is poised to provide broadly applicable information. PMID:26068794

  11. Evaluation of Different Methods of Sperm Immunization in Mice

    Directory of Open Access Journals (Sweden)

    H Moatamed

    2005-07-01

    Full Text Available Introduction: Antifertility effects of naturally occuring antisperm antibody (ASA in infertile couples and studies on experimental immunization of various animals with sperm antigens represent ASA as an immunocontraceptive target. The effects of different factors on sperm immunogenecity and ASA production have been studied and different results have been reported. In this study, whole sperm immunization was evaluated. Methods: In this experimental study, whole mice sperm with different adjuvants i.e. complete Freund’s adjuvant (CFA, incomplete Freund’s adjuvant (ICFA, cholera toxin subunit-β (CTS-β were administrated to mice by different routes; Intramuscular (IM, Subcutaneous (SC, Intranasal (IN, Intra peritoneal (IP, Intrarectal (IR, Intravaginal (IVA and oral. Control groups were inoculated with phosphate buffer saline (PBS plus corresponding adjuvant. Immunization was carried out on day 0,7,14,28 and ASA titers were detected by indirect immunofluorescence (IFA technique. The results were compared between control and experimental groups by Mann Whitney and Fisher exact tests. Results: The number of positive mice for ASA in IM, IN and SC experimental and control groups were significantly different (P=0.01, P=0.01, P=0.04 respectively. However, there were no significant differences between the IR, IVA, and oral experimental and control groups. No differences were observed between ASA in vaginal washing of all groups. Due to high mortality, the IP group was excluded from the study. Conclusion: It can be concluded that whole sperm antigen can induce immune response in female mice by IM, SC and IN routes, but not through IAV, IR and oral administration routes.

  12. Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice.

    Science.gov (United States)

    Sorokin, Alexander V; Yang, Zhi-Hong; Vaisman, Boris L; Thacker, Seth; Yu, Zu-Xi; Sampson, Maureen; Serhan, Charles N; Remaley, Alan T

    2016-09-01

    Aspirin (ASA) is known to alter the production of potent inflammatory lipid mediators, but whether it interacts with omega-3 fatty acids (FAs) from fish oil to affect atherosclerosis has not been determined. The goal was to investigate the impact of a fish oil-enriched diet alone and in combination with ASA on the production of lipid mediators and atherosclerosis. ApoE(-/-) female mice were fed for 13weeks one of the four following diets: omega-3 FA deficient (OD), omega-3 FA rich (OR) (1.8g omega-3 FAs/kg·diet per day), omega-3 FA rich plus ASA (ORA) (0.1g ASA/kg·diet per day) or an omega-3 FA deficient plus ASA (ODA) with supplement levels equivalent to human doses. Plasma lipids, atherosclerosis, markers of inflammation, hepatic gene expression and aortic lipid mediators were determined. Hepatic omega-3 FAs were markedly higher in OR (9.9-fold) and ORA (7-fold) groups. Mice in both OR and ORA groups had 40% less plasma cholesterol in very low-density lipoprotein-cholesterol and low-density lipoprotein fractions, but aortic plaque area formation was only significantly lower in the ORA group (5.5%) compared to the OD group (2.5%). Plasma PCSK9 protein levels were approximately 70% lower in the OR and ORA groups. Proinflammatory aortic lipid mediators were 50%-70% lower in the ODA group than in the OD group and more than 50% lower in the ORA group. In summary, less aortic plaque lesions and aortic proinflammatory lipid mediators were observed in mice on the fish oil diet plus ASA vs. just the fish oil diet. PMID:27394692

  13. Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells.

    Directory of Open Access Journals (Sweden)

    Haider Raza

    Full Text Available We have previously reported that acetylsalicylic acid (aspirin, ASA induces cell cycle arrest, oxidative stress and mitochondrial dysfunction in HepG2 cells. In the present study, we have further elucidated that altered glutathione (GSH-redox metabolism in HepG2 cells play a critical role in ASA-induced cytotoxicity. Using selected doses and time point for ASA toxicity, we have demonstrated that when GSH synthesis is inhibited in HepG2 cells by buthionine sulfoximine (BSO, prior to ASA treatment, cytotoxicity of the drug is augmented. On the other hand, when GSH-depleted cells were treated with N-acetyl cysteine (NAC, cytotoxicity/apoptosis caused by ASA was attenuated with a significant recovery in oxidative stress, GSH homeostasis, DNA fragmentation and some of the mitochondrial functions. NAC treatment, however, had no significant effects on the drug-induced inhibition of mitochondrial aconitase activity and ATP synthesis in GSH-depleted cells. Our results have confirmed that aspirin increases apoptosis by increased reactive oxygen species production, loss of mitochondrial membrane potential and inhibition of mitochondrial respiratory functions. These effects were further amplified when GSH-depleted cells were treated with ASA. We have also shown that some of the effects of aspirin might be associated with reduced GSH homeostasis, as treatment of cells with NAC attenuated the effects of BSO and aspirin. Our results strongly suggest that GSH dependent redox homeostasis in HepG2 cells is critical in preserving mitochondrial functions and preventing oxidative stress associated complications caused by aspirin treatment.

  14. Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat.

    Science.gov (United States)

    Fernández-Dueñas, Víctor; Sánchez, Sílvia; Planas, Eulàlia; Poveda, Raquel

    2008-02-01

    In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition. Acute inflammation was induced by the subplantar injection of carrageenan into the right hind paw, and the effects of the drugs were evaluated from 0 to 5h. Nociception was assessed using the Randall & Selitto test, and the inflammatory response by plethismometry. Oral administration of ASA (10-400mg/kg) induced dose-related anti-nociceptive and anti-inflammatory effects. On the other hand, oral CAF administration (5-50mg/kg) did not show a dose-related inhibitory effect, neither on the inhibition of nociception nor on the inflammatory response. To analyze a possible interaction between both drugs a dose-response curve to ASA plus a fixed dose of CAF (5mg/kg) was obtained 3h after the injection of carrageenan, when the inflammatory pain peaked. A fixed dose of CAF was able to improve the anti-nociceptive, but not the anti-inflammatory, effects of ASA. We also assessed, by enzyme immunoassay, the effects of the combination on peripheral PGE-2 levels: CAF did not alter the inhibitory effect of ASA on PGE-2 synthesis. Our results corroborate the well-known clinical effects of combining ASA and CAF; on the other hand, we rule out that prostaglandin synthesis inhibition at peripheral sites would be the mechanism responsible of the adjuvant anti-nociceptive effect of CAF.

  15. Synergistic and individual effect of glomus etunicatum root colonization and acetyl salicylic acid on root activity and architecture of tomato plants under moderate nacl stress

    International Nuclear Information System (INIS)

    A pot based experiment in plastic tunnel was conducted to investigate the changes in root morphology and root activity of the tomato plants grown under moderate NaCl stress (100 mM), pretreated with arbuscular mycorrhizal fungus AMF (Glomus etunicatum) root colonization and acetyl salicylic acid (ASA) as salinity ameliorative agents. The results revealed that both AMF and ASA treatments significantly enhanced the fresh root weight and root morphological parameters; net length, surface area, volume, mean diameter, nodal count and number of tips to different extents as compared to those of sole salinity treatment at 90 days after transplantation. Both treatments; AMF alone and in combination with ASA significantly enhanced the root activity level in terms of triphenyl tetrazolium chloride (TTC) reduction (2.37 and 2.40 mg g /sup -1/ h /sup -1/ respectively) as compared to the sole salinity treatment (0.40 mg g /sup -1/ h /sup -1/ ) as well as the salt free control (1.69 mg g /sup -1/ h /sup -1/) On the other hand, ASA treatment alone also uplifted root activity (1.53 mg g /sup -1/ h /sup -1/ ) which was significantly higher than that of sole salt treatment. It was inferred that under moderate saline conditions (100 mM NaCl), AMF (Glomus etunicatum) and ASA (individually or in combination) confer protective effect on plant growth by enhanced root activity and improved root architecture. Therefore, synergistic use of AMF (G. etunicatum) and ASA can be eco-friendly and economically feasible option for tomato production in marginally salt affected lands and suggests further investigations. (author)

  16. Adherence with regulatory resolutions on prevention of NSAIDS-related gastrointestinal injury in Italy.

    Science.gov (United States)

    Montagnani, Sabrina; Tuccori, Marco; Testi, Arianna; Cristofano, Michele; Corona, Tiberio; Salvadori, Stefano; Scarpignato, Carmelo; Blandizzi, Corrado

    2016-08-01

    Background The rate of gastrointestinal (GI) complications with non-steroidal antiinflammatory drugs (NSAIDs) or low-dose aspirin (LD-ASA) varies according to risk factors. For at risk patients, the Italian regulatory resolution enforce prophylaxis with proton pump inhibitors (PPIs) or misoprostol. Objective This study evaluated the consistency with such resolution in patients receiving NSAIDs or LD-ASA and assessed whether patients continued to receive GI protection with PPIs for an adequate time following NSAID discontinuation. Setting An observational retrospective study was conducted using data from Health District of Pisa. Methods The analysis was performed on patients receiving prescription of NSAIDs or LD-ASA, with or without concomitant PPIs or misoprostol, accordingly with the presence of risk factors (2008-2010). Prescription data were retrieved from the database of reimbursement claims for dispensed drugs, while history of past GI diseases was obtained from primary or secondary discharge diagnosis. Main outcome measure The consistency rates of PPI and misoprostol prescriptions with Italian regulatory rules in patients receiving chronic NSAIDs or LD-ASA. Results 6869 patients, receiving NSAIDs or LD-ASA during the observation period, were eligible for the analysis. For NSAIDs or LD-ASA, gastroprotection rates in patients without risk factors were: 8 and 6 % in 2008; 10 and 8 % in 2009; 9 and 6 % in 2010; while the proportions of patients with one or more risk factors not receiving gastroprotection were: 12 and 17 % in 2008; 25 and 22 % in 2009; 15 and 17 % in 2010. In patients discontinuing chronic NSAIDs, 62 % were maintained on protection with PPIs, but only 28 % continued the PPI treatment for an adequate time (60 ± 7 days). Conclusions The present analysis, although restricted to prescription patterns in a single health district, suggests scarce levels of consistency with Italian regulatory resolution on the prophylaxis of GI adverse

  17. Time-and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid

    Institute of Scientific and Technical Information of China (English)

    Gang Cheng; Feng An; Mei-Juan Zou; Jin Sun; Xiu-Hua Hao; Yun-Xia He

    2004-01-01

    AIM: To investigate Time- and pH-dependent colon-specific drug delivery systems (CDDS) for orally administered diclofenac sodium (DS) and 5-aminosalicylic acid (5-ASA), respectively.METHODS: DS tablets and 5-ASA pellets were coated by ethylcellulose (EC) and methacrylic acid copolymers (Eudragit[] L100 and S100), respectively. The in vitro release behavior of the DS coated tablets and 5-ASA coated pellets were examined, and then in vivo absorption kinetics of DS coated tablets in dogs were further studied.RESULTS: Release profile of time-dependent DS coated tablets was not influenced by pH of the dissolution medium,but the lag time of DS release was primarily controlled by the thickness of the coating layer. The thicker the coating layer, the longer the lag time of DS release is. On the contrary, in view of the pH-dependent 5-ASA coated pellets,5-ASA release was significantly governed by pH. Moreover,the 5-ASA release features from the coated pellets depended upon both the combination ratio of the Eudragit[] L100 and S100 pH-sensitive copolymers in the coating formulation and the thickness of the coating layer. The absorption kinetic studies of the DS coated tablets in dogs demonstrated that in vivo lag time of absorption was in a good agreement with in vitro lag time of release.CONCLUSION: Two types of CDDS, prepared herein by means of the regular coating technique, are able to achieve site-specific drug delivery targeting at colon following oral administration, and provide a promising strategy to control drug release targeting the desired lower gastrointestinal region.

  18. An Energy Aware Adaptive Sampling Algorithm for Energy Harvesting WSN with Energy Hungry Sensors.

    Science.gov (United States)

    Srbinovski, Bruno; Magno, Michele; Edwards-Murphy, Fiona; Pakrashi, Vikram; Popovici, Emanuel

    2016-01-01

    Wireless sensor nodes have a limited power budget, though they are often expected to be functional in the field once deployed for extended periods of time. Therefore, minimization of energy consumption and energy harvesting technology in Wireless Sensor Networks (WSN) are key tools for maximizing network lifetime, and achieving self-sustainability. This paper proposes an energy aware Adaptive Sampling Algorithm (ASA) for WSN with power hungry sensors and harvesting capabilities, an energy management technique that can be implemented on any WSN platform with enough processing power to execute the proposed algorithm. An existing state-of-the-art ASA developed for wireless sensor networks with power hungry sensors is optimized and enhanced to adapt the sampling frequency according to the available energy of the node. The proposed algorithm is evaluated using two in-field testbeds that are supplied by two different energy harvesting sources (solar and wind). Simulation and comparison between the state-of-the-art ASA and the proposed energy aware ASA (EASA) in terms of energy durability are carried out using in-field measured harvested energy (using both wind and solar sources) and power hungry sensors (ultrasonic wind sensor and gas sensors). The simulation results demonstrate that using ASA in combination with an energy aware function on the nodes can drastically increase the lifetime of a WSN node and enable self-sustainability. In fact, the proposed EASA in conjunction with energy harvesting capability can lead towards perpetual WSN operation and significantly outperform the state-of-the-art ASA. PMID:27043559

  19. 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro

    Institute of Scientific and Technical Information of China (English)

    Hai-Ming Fang; Qiao Mei; Jian-Ming Xu; Wei-Juan Ma

    2007-01-01

    AIM:To investigate the effects of 5-aminosalicylic acid (5-ASA) in combination with nimesulide on the proliferation of HT-29 colon carcinoma cells and its potential mechanisms.METHODS: Inhibitory effects of drugs (5-ASA,nimesulide and their combination) on HT-29 colon carcinoma cells were investigated by thiazolyl blue tetrazolium bromide (MTT) assay. Cellular apoptosis and proliferation were detected by TUNEL assay and immunocytochemical staining, respectively.RESULTS: Pretreatment with 5-ASA or nimesulide at the concentration of 10-1000 μmol/L inhibited proliferation of HT-29 colon carcinoma cells in a dose-dependent manner in vitro (t = 5.122, P < 0.05; t = 3.086, P <0.05, respectively). The inhibition rate of HT-29 colon carcinoma cell proliferation was also increased when pretreated with 5-ASA (100 μmol/L) or nimesulide (100μmol/L) for 12-96 h, which showed an obvious timeeffect relationship (t = 6.149, P < 0.05; t = 4.159, P< 0.05, respectively). At the concentration of 10-500μmol/L, the apoptotic rate of HT-29 colon carcinoma cells significantly increased (t = 18.156, P < 0.001; t =19.983, P < 0.001, respectively), while expression of proliferating cell nuclear antigen (PCNA) was remarkably decreased (t = 6.828, P < 0.05; t = 14.024, P < 0.05,respectively). 5-ASA in combination with nimesulide suppressed the proliferation of HT-29 colon carcinoma cells more than either of these agents in a dosedependent and time-dependent manner (t = 5.448, P <0.05; t = 4.428, P < 0.05, respectively).CONCLUSION: 5-ASA and nimesulide may inhibit the proliferation of HT-29 colon carcinoma cells and coadministration of these agents may have additional chemopreventive potential.

  20. ASTHMA AND RHINITIS INDUCED BY SELECTIVE IMMEDIATE REACTIONS TO PARACETAMOL AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN ASPIRIN TOLERANT SUBJECTS

    Directory of Open Access Journals (Sweden)

    Diana Pérez-Alzate

    2016-07-01

    Full Text Available In subjects with non-steroidal anti-inflammatory drugs (NSAIDs- exacerbated respiratory disease (NERD symptoms are triggered by acetyl salicylic acid (ASA and other strong COX-1 inhibitors, and in some cases by weak COX-1 or by selective COX-2 inhibitors. The mechanism involved is related to prostaglandin pathway inhibition and leukotriene release. Subjects who react to a single NSAID and tolerate others are considered selective responders, and often present urticaria and/or angioedema and anaphylaxis (SNIUAA. An immunological mechanism is implicated in these reactions. However, anecdotal evidence suggests that selective responders who present respiratory airway symptoms may also exist.Our objective was to determine if subjects might develop selective responses to NSAIDs/paracetamol that manifest as upper/lower airways respiratory symptoms. For this purpose we studied patients reporting asthma and/or rhinitis induced by paracetamol or a single NSAID that tolerated ASA. An allergological evaluation plus controlled challenge with ASA was carried out. If ASA tolerance was found, we proceeded with an oral challenge with the culprit drug. The appearance of symptoms was monitored by a clinical questionnaire and by measuring FEV1 and/or nasal airways volume changes pre and post challenge. From a total of 21 initial cases, we confirmed the appearance of nasal and/or bronchial manifestations in ten, characterised by a significant decrease in FEV1% and/or a decrease in nasal volume cavity after drug administration. All cases tolerated ASA.This shows that ASA tolerant subjects with asthma and/or rhinitis induced by paracetamol or a single NSAID without skin/systemic manifestations exist. Whether these patients represent a new clinical phenotype to be included within the current classification of hypersensitivity reactions to NSAIDs requires further investigation.

  1. Asthma and Rhinitis Induced by Selective Immediate Reactions to Paracetamol and Non-steroidal Anti-inflammatory Drugs in Aspirin Tolerant Subjects

    Science.gov (United States)

    Pérez-Alzate, Diana; Blanca-López, Natalia; Doña, Inmaculada; Agúndez, José A.; García-Martín, Elena; Cornejo-García, José A.; Perkins, James R.; Blanca, Miguel; Canto, Gabriela

    2016-01-01

    In subjects with non-steroidal anti-inflammatory drugs (NSAIDs)- exacerbated respiratory disease (NERD) symptoms are triggered by acetyl salicylic acid (ASA) and other strong COX-1 inhibitors, and in some cases by weak COX-1 or by selective COX-2 inhibitors. The mechanism involved is related to prostaglandin pathway inhibition and leukotriene release. Subjects who react to a single NSAID and tolerate others are considered selective responders, and often present urticaria and/or angioedema and anaphylaxis (SNIUAA). An immunological mechanism is implicated in these reactions. However, anecdotal evidence suggests that selective responders who present respiratory airway symptoms may also exist. Our objective was to determine if subjects might develop selective responses to NSAIDs/paracetamol that manifest as upper/lower airways respiratory symptoms. For this purpose, we studied patients reporting asthma and/or rhinitis induced by paracetamol or a single NSAID that tolerated ASA. An allergological evaluation plus controlled challenge with ASA was carried out. If ASA tolerance was found, we proceeded with an oral challenge with the culprit drug. The appearance of symptoms was monitored by a clinical questionnaire and by measuring FEV1 and/or nasal airways volume changes pre and post challenge. From a total of 21 initial cases, we confirmed the appearance of nasal and/or bronchial manifestations in ten, characterized by a significant decrease in FEV1% and/or a decrease in nasal volume cavity after drug administration. All cases tolerated ASA. This shows that ASA tolerant subjects with asthma and/or rhinitis induced by paracetamol or a single NSAID without skin/systemic manifestations exist. Whether these patients represent a new clinical phenotype to be included within the current classification of hypersensitivity reactions to NSAIDs requires further investigation. PMID:27489545

  2. Diversity and homogeneity among small plasmids of Aeromonas salmonicida subsp. salmonicida linked with geographical origin

    Directory of Open Access Journals (Sweden)

    Sabrina A Attéré

    2015-11-01

    Full Text Available Furunculosis, which is caused by Aeromonas salmonicida subsp. salmonicida, is a major salmonid disease in fish farms worldwide. Several plasmids found in this bacterium confer phenotypes such drug resistance and virulence. Small plasmids (pAsa1, pAsa2, pAsa3, and pAsal1 related to ColE1- and ColE2-type replicons are usually present in its normal plasmidome. In the present study, with the objective to investigate if these plasmids display particularities related to the origin of the isolates bearing them, a total of 153 isolates, including 78 new and 75 previously described, were analyzed for the presence of small plasmids by PCR and DNA restriction fragment profiling. A geographical dichotomy between Canadian and European isolates for their propensity to do not have pAsa3 or pAsal1 was found. In addition, the genotyping analysis led to the identification of two European isolates harboring an unusual pAsal1. An investigation by next-generation sequencing (NGS of these two isolates shed light on two pAsal1 variants (pAsal1C and pAsal1D. As with pAsal1B, another pAsal1 variant previously described, these two new variants bore a second insertion sequence (ISAS5 in addition to the usual ISAS11. The characterization of these variants suggested that they could predominate over the wild-type pAsal1 in stressful conditions such as growth at temperatures of 25°C and above. To obtain a comprehensive portrait of the mutational pressure on small plasmids, 26 isolates whose DNA had been sequenced by NGS were investigated. pAsa3 and pAsal1 were more prone to mutations than pAsa1 and pAsa2, especially in the mobA gene, which encodes a relaxase and a primase. Lastly, the average copy number of each plasmid per cell was assessed using raw sequencing data. A clear trend with respect to the relative proportion per cell of each plasmid was identified. Our large-scale study revealed a geographical dichotomy in small plasmid repertoire in addition to a clear trend

  3. Problematika Putusan Hakim dalam Perkara Pembatalan Perjanjian

    Directory of Open Access Journals (Sweden)

    Nindyo Pramono

    2012-02-01

    Full Text Available The rapid development of international business law requires judges to re-scrutinise principles of contract law in the Civil Code. Therefore, principles of good faith, protection of third-party, retroaction, and restoration to pre-contract position will be analysed to provide objectively constructive feedback for judges when hearing over request for contract annulment.  Pesatnya perkembangan hukum bisnis internasional mengharuskan hakim untuk mempelajari kembali asas-asas hukum perjanjian dalam KUHPerdata. Prinsipprinsip itikad baik, perlindungan bagi pihak ketiga, retroaktif, dan kembali ke keadaan semula akan dianalisis dalam tulisan ini sehingga memberikan konstruksi obyektif kepada hakim dalam memutus permohonan pembatalan perjanjian agar jangan sampai menimbulkan perkara baru.

  4. Genetic introgression of ethylene-suppressed transgenic tomatoes with higher-polyamines trait overcomes many unintended effects due to reduced ethylene on the primary metabolome

    Directory of Open Access Journals (Sweden)

    Anatoly P Sobolev

    2014-12-01

    Full Text Available Ethylene regulates a myriad physiological and biochemical processes in ripening fruits and is accepted as the ripening hormone for the climacteric fruits. However, its effects on metabolome and resulting fruit quality are not yet fully understood, particularly when some of the ripening-associated biochemical changes are independent of ethylene action. We have generated a homozygous transgenic tomato genotype (2AS-AS that exhibits reduced ethylene production as a result of impaired expression of 1-aminocyclopropane-1-carboxylate synthase 2 gene by its antisense RNA and had a longer shelf life. Double transgenic hybrid (2AS-AS x 579HO developed through a genetic cross between 2AS-AS and 579HO (Mehta et al., 2002 lines resulted in significantly higher ethylene production than either the WT or 2AS-AS fruit. To determine the effects of reduced ethylene and introgression of higher polyamines’ trait, the metabolic profiles of ripening fruits from WT (556AZ, 2AS-AS, and 2AS-AS x 579HO lines were determined using 1H-NMR spectroscopy. The levels of Glu, Asp, AMP, Adenosine, Nucl1 and Nucl2 increased during ripening of the WT fruit. The increases in Glu, Asp, and AMP levels were attenuated in 2AS-AS fruit but recovered in the double hybrid with higher ethylene and polyamine levels. The ripening-associated decreases in Ala, Tyr, Val, Ile, Phe, malate and myo-inositol levels in the 2AS-AS line were not reversed in the double hybrid line suggesting a developmental/ripening regulated accumulation of these metabolites independent of ethylene. Significant increases in the levels of fumarate, formate, choline, Nucl1 and Nucl2 at most stages of ripening fruit were found in the double transgenic line due to introgression with higher-polyamines trait. Taken together these results show that the ripening-associated metabolic changes are both ethylene dependent and independent, and that the fruit metabolome is under the control of multiple regulators, including

  5. Comparison of the concentration-effect relationship of a local antiinflammatory agent and oral acetylsalicylic acid: the value of local application.

    Science.gov (United States)

    Poisson, M; Ralambosoa, C; Blehaut, H; Astoin, J

    1985-01-01

    Using a pharmacological model, the comparison between acetylsalicylic acid (ASA), administered orally, and a solution combining two salicylate derivatives (ethyl 5-methoxy-salicylate and 3-phenyl-propyl-salicylate), applied locally, demonstrated the value of the local application. Indeed, the pharmacological activity was highly significant and directly related to the tissue concentration of salicyl ions, which was higher after local application of the solution than after oral administration of ASA. The local solution also resulted in a lower plasma concentration of salicylate ions, allowing high plasma salicylate concentrations to be avoided. PMID:4074414

  6. Control of cucumber (Cucumis sativus L.) tolerance to chilling stress—evaluating the role of ascorbic acid and glutathione

    OpenAIRE

    Lukatkin, Alexander S.; Anjum, Naser A.

    2014-01-01

    Chilling temperatures (1–10°C) are known to disturb cellular physiology, cause oxidative stress via creating imbalance between generation and metabolism of reactive oxygen species (ROS) leading finally to cell and/or plant death. Owing to known significance of low molecular antioxidants—ascorbic acid (AsA) and glutathione (GSH) in plant stress-tolerance, this work analyzes the role of exogenously applied AsA and GSH in the alleviation of chilling stress (3°C)-impact in cucumber (Cucumis sativ...

  7. Sexual Victimization, Alcohol Intoxication, Sexual-Emotional Responding, and Sexual Risk in Heavy Episodic Drinking Women

    OpenAIRE

    George, William H.; Davis, Kelly Cue; Masters, N. Tatiana; Jacques-Tiura, Angela J.; Heiman, Julia R.; Norris, Jeanette; Gilmore, Amanda K.; Nguyen, Hong V.; Kajumulo, Kelly F.; Otto, Jacqueline M.; Andrasik, Michele P.

    2013-01-01

    This study used an experimental paradigm to investigate the roles of sexual victimization history and alcohol intoxication in young women’s sexual-emotional responding and sexual risk taking. A nonclinical community sample of 436 young women, with both an instance of heavy episodic drinking and some HIV/STI risk exposure in the past year, completed childhood sexual abuse (CSA) and adolescent/adult sexual assault (ASA) measures. A majority of them reported CSA and/or ASA, including rape and at...

  8. The study of acetylsalicylic acid effects on wheat seeds germination in salt stress conditions

    OpenAIRE

    Sorin Tănasa; Vasilica Barbu

    2010-01-01

    The present study was conducted in order to determine whether a treatment using acetylsalicylic acid (ASA) would increase the germinative energy of wheat seeds in conditions of salt stress. Wheat seeds were immersed in six solutions of ASA of different concentrations (0, 0.1, 0.5, 1, 2 and 3 mM) and then germinated in two solutions of different levels of salinity (one replicating normal conditions of salinity in crop soils, and one reproducing the conditions present in salty soil). The optimu...

  9. Long-term use of antiplatelet drugs by stroke patients

    DEFF Research Database (Denmark)

    Ostergaard, Kamilla; Hallas, Jesper; Bak, Søren;

    2012-01-01

    PURPOSE: Treatment with antiplatelet drugs is a key element of secondary stroke prevention. We investigated long-term antiplatelet drug use in stroke patients with a focus on non-persistence. METHODS: Population-based prescription register data were used to determine antiplatelet drug use...... in a cohort of stroke patients discharged from a Danish neurology department. The antiplatelet drugs comprised acetylsalicylic acid (ASA), clopidogrel and dipyridamole (if combined with ASA use). Non-persistence was defined as failure to present a prescription for antiplatelet drugs within 180 days after...

  10. Security of Linear Secret-Sharing Schemes Against Mass Surveillance

    DEFF Research Database (Denmark)

    Giacomelli, Irene; Olimid, Ruxandra; Ranellucci, Samuel

    2015-01-01

    by a proprietary code that the provider (“big brother”) could manipulate to covertly violate the privacy of the users (by implementing Algorithm-Substitution Attacks or ASAs). First, we formalize the security notion that expresses the goal of big brother and prove that for any linear secret-sharing scheme...... there exists an undetectable subversion of it that efficiently allows surveillance. Second, we formalize the security notion that assures that a sharing scheme is secure against ASAs and construct the first sharing scheme that meets this notion....

  11. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach.

    Science.gov (United States)

    Palus, Katarzyna; Całka, Jarosław

    2015-01-01

    This experiment was designed to establish the localization and neurochemical phenotyping of sympathetic neurons supplying prepyloric area of the porcine stomach in a physiological state and during acetylsalicylic acid (ASA) induced gastritis. In order to localize the sympathetic perikarya the stomachs of both control and acetylsalicylic acid treated (ASA group) animals were injected with neuronal retrograde tracer Fast Blue (FB). Seven days post FB injection, animals were divided into a control and ASA supplementation group. The ASA group was given 100 mg/kg of b.w. ASA orally for 21 days. On the 28th day all pigs were euthanized with gradual overdose of anesthetic. Then fourteen-micrometer-thick cryostat sections were processed for routine double-labeling immunofluorescence, using primary antisera directed towards tyrosine hydroxylase (TH), dopamine β-hydroxylase (DβH), neuropeptide Y (NPY), galanin (GAL), neuronal nitric oxide synthase (nNOS), leu 5-enkephalin (LENK), cocaine- and amphetamine- regulated transcript peptide (CART), calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP). The data obtained in this study indicate that postganglionic sympathetic nerve fibers supplying prepyloric area of the porcine stomach originate from the coeliac-cranial mesenteric ganglion complex (CCMG). In control animals, the FB-labelled neurons expressed TH (94.85 ± 1.01%), DβH (97.10 ± 0.97%), NPY (46.88 ± 2.53%) and GAL (8.40 ± 0.53%). In ASA group, TH- and DβH- positive nerve cells were reduced (85.78 ± 2.65% and 88.82 ± 1.63% respectively). Moreover, ASA- induced gastritis resulted in increased expression of NPY (76.59 ± 3.02%) and GAL (26.45 ± 2.75%) as well as the novo-synthesis of nNOS (6.13 ± 1.11%) and LENK (4.77 ± 0.42%) in traced CCMG neurons. Additionally, a network of CART-, CGRP-, SP-, VIP-, LENK-, nNOS- immunoreactive (IR) nerve fibers encircling the FB-positive perikarya were observed in both intact and ASA

  12. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach.

    Directory of Open Access Journals (Sweden)

    Katarzyna Palus

    Full Text Available This experiment was designed to establish the localization and neurochemical phenotyping of sympathetic neurons supplying prepyloric area of the porcine stomach in a physiological state and during acetylsalicylic acid (ASA induced gastritis. In order to localize the sympathetic perikarya the stomachs of both control and acetylsalicylic acid treated (ASA group animals were injected with neuronal retrograde tracer Fast Blue (FB. Seven days post FB injection, animals were divided into a control and ASA supplementation group. The ASA group was given 100 mg/kg of b.w. ASA orally for 21 days. On the 28th day all pigs were euthanized with gradual overdose of anesthetic. Then fourteen-micrometer-thick cryostat sections were processed for routine double-labeling immunofluorescence, using primary antisera directed towards tyrosine hydroxylase (TH, dopamine β-hydroxylase (DβH, neuropeptide Y (NPY, galanin (GAL, neuronal nitric oxide synthase (nNOS, leu 5-enkephalin (LENK, cocaine- and amphetamine- regulated transcript peptide (CART, calcitonin gene-related peptide (CGRP, substance P (SP and vasoactive intestinal peptide (VIP. The data obtained in this study indicate that postganglionic sympathetic nerve fibers supplying prepyloric area of the porcine stomach originate from the coeliac-cranial mesenteric ganglion complex (CCMG. In control animals, the FB-labelled neurons expressed TH (94.85 ± 1.01%, DβH (97.10 ± 0.97%, NPY (46.88 ± 2.53% and GAL (8.40 ± 0.53%. In ASA group, TH- and DβH- positive nerve cells were reduced (85.78 ± 2.65% and 88.82 ± 1.63% respectively. Moreover, ASA- induced gastritis resulted in increased expression of NPY (76.59 ± 3.02% and GAL (26.45 ± 2.75% as well as the novo-synthesis of nNOS (6.13 ± 1.11% and LENK (4.77 ± 0.42% in traced CCMG neurons. Additionally, a network of CART-, CGRP-, SP-, VIP-, LENK-, nNOS- immunoreactive (IR nerve fibers encircling the FB-positive perikarya were observed in both intact and ASA

  13. Multivariate density estimation theory, practice, and visualization

    CERN Document Server

    Scott, David W

    2015-01-01

    David W. Scott, PhD, is Noah Harding Professor in the Department of Statistics at Rice University. The author of over 100 published articles, papers, and book chapters, Dr. Scott is also Fellow of the American Statistical Association (ASA) and the Institute of Mathematical Statistics. He is recipient of the ASA Founder's Award and the Army Wilks Award. His research interests include computational statistics, data visualization, and density estimation. Dr. Scott is also Coeditor of Wiley Interdisciplinary Reviews: Computational Statistics and previous Editor of the Journal of Computational and

  14. Feasibility of non-linear simulation for Field II using an angular spectrum approach

    DEFF Research Database (Denmark)

    Du, Yigang; Jensen, Jørgen Arendt

    2008-01-01

    this procedure is to find the accuracy of the approach for linear propagation, where the result can be validated using Field II simulations. The ASA calculations are carried out by 3D fast Fourier transform using Matlab, where lambda=2 is chosen as the spatial sampling rate to reduce aliasing errors. Zero...... is restricted to simulate these for the linear case and the purpose of this paper is to develop a general frame work for extending it to non-linear simulation. The extension to the non-linear domain is made by using the angular spectrum approach (ASA), where the field is calculated in a plane close...

  15. Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug

    Directory of Open Access Journals (Sweden)

    Cristiana Perrotta

    2015-01-01

    Full Text Available Inflammatory bowel disease (IBD comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn’s disease are the commonest forms. This disease has a significant prevalence and it is of an unknown aethiology. Five-aminosalicylic acid (5-ASA and its derivatives are among the oldest drugs approved for the treatment of the IBD. In this review we reapprise aspects of 5-ASA mechanism of action, safety, and efficacy that in our opinion make it a valuable drug that can be fruitfully tailored in personalised treatments as a therapeutic option alongside other immune-modifying agents.

  16. A dynamic model of once-daily 5-aminosalicylic acid predicts clinical efficacy

    Institute of Scientific and Technical Information of China (English)

    Deepak; Parakkal; Eli; D; Ehrenpreis; Matthew; P; Thorpe; Karson; S; Putt; Bruce; Hannon

    2010-01-01

    New once daily mesalamine formulations may improve adherence to medication usage.Response to Asacol and other forms of 5-aminosalicyclic acid(5-ASA)is better correlated with tissue concentrations and best predicted by concentrations of the drug within the lumen of the colon.Our group used computer simulation to predict colonic 5-ASA levels after Asacol administration.In our study,the model simulated Asacol distribution in the healthy colon,and during quiescent and active ulcerative colitis.An Asacol dosage ...

  17. Long-term efficacy and safety of once-daily mesalazine granules for the treatment of active ulcerative colitis.

    Science.gov (United States)

    Böhm, Stephan Karl; Kruis, Wolfgang

    2014-01-01

    In 1977, 5-aminosalicylic acid (5-ASA) was discovered as a therapeutically active moiety of sulfasalazine (SASP) and was launched for topical and oral therapy of ulcerative colitis (UC) in 1984. As a first-step, delivery systems had to be developed to protect 5-ASA against absorption in the upper gastrointestinal tract, resulting in different and competing strategies (azo compounds, controlled release, and pH-dependent release). In a second step, at the beginning of the new century, coinciding with the expiration of patent protection for the first 5-ASA formulations, two component composite release mechanisms (pH-dependent and controlled release) were developed. Furthermore, the drug was formulated as granules instead of tablets, allowing higher unit strengths compared with tablets. Neither Salofalk Granu-Stix(®), nor MMX 5-ASA, nor Pentasa(®) granules have initially been developed for once-daily (OD) dosing. A review of the achievements of 20 years of 5-ASA development has demonstrated that 5-ASA has equal efficacy compared with SASP at best, that there are no measurable differences in efficacy between various 5-ASA preparations, and that in a group of patients tolerating SASP, adverse event profiles of SASP and 5-ASA did not differ significantly, with SASP being the far cheaper substance. Therefore, drug adherence came into focus as a new goal for improving UC therapy. Although adherence is a complex and multifactorial construct, a simple dosing schedule may contribute to higher drug adherence and better efficacy of treatment. Simultaneously, the US 5-ASA market, estimated to be worth US$1.4 billion, is expected to grow continuously. Naturally, this very competitive market is not only driven by scientific progress but also by commercial interests. Thus, patents for minor changes to the formulation may serve as protection against drug companies trying to launch generic versions. Randomized controlled trials performed on OD dosing in induction of remission have

  18. Long-term efficacy and safety of once-daily mesalazine granules for the treatment of active ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Böhm SK

    2014-09-01

    Full Text Available Stephan Karl Böhm,1 Wolfgang Kruis2 1Kantonsspital Baselland, Medizinische Universitätsklinik, Bruderholz, Switzerland; 2Evangelisches Krankenhaus Kalk, University of Cologne, Cologne, Germany Abstract: In 1977, 5-aminosalicylic acid (5-ASA was discovered as a therapeutically active moiety of sulfasalazine (SASP and was launched for topical and oral therapy of ulcerative colitis (UC in 1984. As a first-step, delivery systems had to be developed to protect 5-ASA against absorption in the upper gastrointestinal tract, resulting in different and competing strategies (azo compounds, controlled release, and pH-dependent release. In a second step, at the beginning of the new century, coinciding with the expiration of patent protection for the first 5-ASA formulations, two component composite release mechanisms (pH-dependent and controlled release were developed. Furthermore, the drug was formulated as granules instead of tablets, allowing higher unit strengths compared with tablets. Neither Salofalk Granu-Stix®, nor MMX 5-ASA, nor Pentasa® granules have initially been developed for once-daily (OD dosing. A review of the achievements of 20 years of 5-ASA development has demonstrated that 5-ASA has equal efficacy compared with SASP at best, that there are no measurable differences in efficacy between various 5-ASA preparations, and that in a group of patients tolerating SASP, adverse event profiles of SASP and 5-ASA did not differ significantly, with SASP being the far cheaper substance. Therefore, drug adherence came into focus as a new goal for improving UC therapy. Although adherence is a complex and multifactorial construct, a simple dosing schedule may contribute to higher drug adherence and better efficacy of treatment. Simultaneously, the US 5-ASA market, estimated to be worth US$1.4 billion, is expected to grow continuously. Naturally, this very competitive market is not only driven by scientific progress but also by commercial interests

  19. SBA-15分子筛用于组装二溴对氯偶氮胂%USE OF MOLECULAR SIEVE SBA - 15 FOR INCORPORATION OF DIBROMOCHLORO-ARSENAZO

    Institute of Scientific and Technical Information of China (English)

    翟庆洲; 于辉; 蔡建岩; 秦亮

    2006-01-01

    Molecular sieve (SBA - 15)-(dibromochloro-arsenazo, DBC-ASA) host-guest composite materials were prepared by a liquid-phase grafting method using the calcined SBA- 15 molecular sieve as the host material, the DBC-ASA solution as the guest material, and water as the medium. The composite materials (SBA- 15)-(DBC-ASA) were characterized by X-ray diffraction(XRD), Fourier transform infrared(FTIR)spectra, solid state diffuse reflectance absorption spectra, and luminescence studies. The XRD results show that the molecular sieve framework in the (SBA- 15)-(DBC-ASA) host-guest composite materials is retained, and is highly ordered. The FTIR spectra indicate that the framework of the SBA- 15 molecular sieve is retained when a small amount of DBC-ASA is incorporated into it, the order degree of the molecular sieve decreases when a large amount of DBC-ASA is incorporated into it. The solid state diffuse reflectance absorption spectra show that DBC-ASA is located in the channel of the SBA - 15 molecular sieve, and the channel of SBA - 15 has stereoconfinment. The luminescence spectra show a strong non-radiation transition processes in the prepared samples, and this results in very strong electron-photon interaction causing a charge transfer transition. The Stokes displacement takes place and the spectrum bands broaden.%以煅烧的分子筛SBA-15为主体材料,二溴对氯偶氮胂(dibromochloro-arsenazo,DBC-ASA)作客体材料,以水为介质,用液相移植法制备了(SBA-15)-(DBC-ASA)主客体复合材料.用粉末X射线衍射、Fourier变换红外光谱、固体扩散漫反射吸收光谱及发光研究表征了所制得的复合材料(SBA-15)-(DBC-ASA)的性质.X射线衍射结果表明:(SBA-15)-(DBC-ASA)主客体复合材料分子筛骨架存在且有序度高.红外光谱分析表明:较低量的DBC-ASA引入SBA-15分子筛中,分子筛骨架结构仍然存在,但引入量较大时,分子筛的骨架有序度明显降低.固体扩散漫反射吸收光谱研

  20. Pharmacological Correction of the Negative Effect of Acetylsalicylic Acid on the Energy-Generating System

    Directory of Open Access Journals (Sweden)

    Vladimir V. Udut, ScD

    2012-03-01

    Full Text Available The present paper demonstrates the effect of ASA and its combination with SUC on the energy-producing system of rat heart mitochondria as well as an assessment of SUC preventive application effect on ASA pharmacokinetic parameters. Experiments conducted on outbred male albino rats (200-250 g on a model of a xenobiotic load induced by seven days of intragastric injections of acetylsalicylic acid at a dose of 250 mg/kg have shown inhibition of the oxygen consumption rates in the heart mitochondria as well as a limitation of the succinate-dependent substrate oxidation pathways and a decrease in the mitochondria ATP/ADP coefficient. Succinic acid (50 mg/kg for 7 days was injected as a preventive medication to correct the mitochondrial bioenergetics revealed. A comparative research of the pharmacokinetics of acetylsalicylic acid and acetylsalicylic acid against the background of succinic acid performed on the model of rabbits has shown total similarity in the parameters analyzed. This fact demonstrates the possibility of prevention of mitochondrial dysfunction using the intermediate Krebs cycle. SUC as preventive medication promotes the elimination of ASA-induced negative metabolic shifts in the rat heart mitochondria by normalizing the succinate- and NAD-dependent respiration, oxidative phosphorylation, and therefore, it finds good use in the correction of ASA-induced negative side-effects of an energy-generating system

  1. Systematic review

    DEFF Research Database (Denmark)

    Andersen, Vibeke; Vogel, U

    2014-01-01

    BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) include aspirin (acetylsalicylic acid, ASA). Long-term use of NSAIDs has been associated with lowered risk of colorectal cancer (CRC), but the use is hampered by adverse effects. Also, the anti-carcinogenic effects of NSAIDs are incompletely...

  2. Prognostic factors influencing morbidity and mortality in esophageal carcinoma

    Directory of Open Access Journals (Sweden)

    Cariati Andrea

    2002-01-01

    Full Text Available PURPOSE: In 1980, operative mortality for esophageal resection was 29%. Over the last 15 years, technical and critical care improvements contributed to the reduction of postoperative mortality rate to 8%. The aim of this study is to analyze retrospectively the role of different factors (surgical procedure, stage of the disease, and anesthetic risk on the postoperative mortality of 63 patients that underwent esophagectomy with gastric interposition for cancer. METHODS: Seventy-two patients underwent esophagectomy. The stomach was the esophageal substitute in 63 cases. Surgical procedures included transthoracic esophagectomy in 49 patients and transhiatal esophagectomy in 14 cases. Among the 49 transthoracic esophagectomy patients, there were 18 patients with a high anesthetic risk (ASA III. Among the patients that underwent transhiatal esophagectomy, there were 10 patients with a high anesthetic risk (ASA III. RESULTS: The operative mortality rate was 14% (2/14 in transhiatal esophagectomy group and 22% (11/49 in transthoracic esophagectomy group (P = ns. The postoperative mortality of patients with a high anesthetic risk (ASA III was 47% (8/17 after transthoracic esophagectomy and 10% (1/10 after transhiatal esophagectomy (P <0.05. DISCUSSION: In our experience, the operative mortality was nearly 18% (16.6% after transhiatal esophagectomy and 20.8% after transthoracic esophagectomy. Among the patients with a high anesthetic risk (ASA III that underwent surgery, the postoperative mortality was significantly lower after transhiatal esophagectomy (10% compared to transthoracic esophagectomy (47% (P <0.05.

  3. Aspirin treatment of the low-dose-endotoxin-treated pregnant rat : Pathophysiologic and immunohistologic aspects

    NARCIS (Netherlands)

    Faas, MM; Schuiling, GA; Baller, JFW; Valkhof, N; Bakker, WW

    1997-01-01

    In the present study, we evaluated the effect of low-dose aspirin (acetylsalicylic acid (ASA); 1.0 mg/kg daily) on blood pressure, albumin excretion, glomerular fibrinogen deposits, and glomerular (basement) membrane-bound adenosine diphosphatase (ecto-ADPase) activity, as well as on glomerular infl

  4. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II)

    DEFF Research Database (Denmark)

    Rudwaleit, M; van der Heijde, D; Landewé, R;

    2009-01-01

    OBJECTIVE: To validate and refine two sets of candidate criteria for the classification/diagnosis of axial spondyloarthritis (SpA). METHODS: All Assessment of SpondyloArthritis international Society (ASAS) members were invited to include consecutively new patients with chronic (> or =3 months) ba...

  5. Interatrial shunt. Diagnosis of patent foramen ovale and atrial septal defect with 64-row coronary computed tomography angiography

    International Nuclear Information System (INIS)

    The aim of this study was to investigate the frequency with which interatrial shunts are found during routine coronary computed tomography (CT) angiography and to describe imaging characterizations of patent foramen ovale (PFO), atrial septal defect (ASD), and atrial septal aneurysm (ASA). A total of 1081 adult patients were evaluated retrospectively for interatrial shunting; 77 were excluded from the study. CT diagnosis of PFO was defined as (1) a channel-like appearance of the interatrial septum (IAS) and (2) a contrast agent jet flow from the left atrium (LA) to the right atrium (RA). ASD was defined as (1) the IAS resembling a membrane with a hole and (2) a contrast jet flow between the two atria. ASA was identified by detecting a minimum 10-mm protrusion of the LA beyond the IAS into the RA. Among 1004 patients, 86 patients (8.6%) were diagnosed to have PFO. Another 23 patients (2.3%) had a hole in the IAS and were diagnosed as having ASD: 21 with an ostium secundum-type ASD and 2 with the sinus venosus type. ASA accompanied ASD in three patients. Electrocardiography-gated CT using the saline-chaser contrast injection technique that is routinely used for coronary arterial imaging can be used to detect interatrial shunts. The technique can also serve as a method for differentiating PFO, ASD, and ASA. (author)

  6. Skulptuuripäevad Pärnus

    Index Scriptorium Estoniae

    2003-01-01

    4.-15. VIII Pärnus Vallikääru aasal 3. rahvusvahelised skulptuuripäevad "Pärnu positiivne märk". Osalevad Serge Samyn (Prantsusmaa), Kestutis Lanauskaټ (Leedu), Asa Hauksdottir (Island), Meeland Sepp, Toomas Kuusing, Toomas Altnurme, Rait Pärg (korraldaja). Lastele vanuses 7-15 avatud töötuba juhendab Eneken Maripuu

  7. Evaluation of intra ocular pressure and hemodynamic change following intubation with Maccoy, Macintosh and Video laryngoscope

    OpenAIRE

    Hamid Khosro Zamiri; Mehrdad Noroozi; Siavash Moradi; Mohammad Shabani; Ali Sharifi; Mohammad Ali Haghbin

    2013-01-01

    Background & Objective: The induction of anesthesia, laryngoscopy and endotracheal intubation can be associated with adverse hemodynamic response and increased intraocular pressure. The aim of this study was to evaluate intraocular pressure and hemodynamic changes after laryngoscopy and endotracheal intubation with three methods of laryngoscopy (Macintosh, Maccoy and Video laryngoscope).Materials & Methods: One hundred and eighty patients with American Society of Anesthesiology (ASA) classifi...

  8. POST-OPERATIVE VENTRICULAR TACHYCARDIA LEADING TO CARDIAC ARREST IN AN ASAG- I PATIENT OF CHOLECYSTECTOMY: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Pradip

    2014-03-01

    Full Text Available We here present our experience with ventricular tachycardia (VT leading to cardiac arrest in a patient with American Society of Anesthesiologists grade-I (ASA-I 11 hours after cholecystectomy. Excessive fluid overload and hypoxemia due to lung congestion may lead to cardiac arrest in this case. Immediate diagnosis and appropriate intervention saved the life of the patient.

  9. Colon-specific drug delivery behavior of pH-responsive PMAA/perlite composite.

    Science.gov (United States)

    Mahkam, Mehrdad; Vakhshouri, Laleh

    2010-04-12

    The preparation, characterization, and in vitro release of 5-aminosalicylic acid (5-ASA) from methacrylic acid (MAA)/perlite composites (APC) prepared via a sol-gel route are reported. The free-radical graft polymerization of methacrylic acid (MAA) onto perlite particles was studied experimentally. The grafting procedure consisted of surface activation with 3-(trimethoxysilyl) propyl methacrylate (TSPA), followed by free-radical graft polymerization of methacrylic acid (MAA) in ethyl acetate with 2,2'-azobisisobutyronitrile (AIBN) initiator. The composition of the composites hybrid materials was determined by FTIR spectroscopy. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The dried composites were immersed in a saturated solution of 5-ASA in water overnight and dried over a period of three days at room temperature and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The 5-ASA concentration of the solution was measured using a UV-Vis spectrophotometer (205 nm) at different time intervals. The in vitro drug release test revealed that the release rate of 5-ASA in buffer solutions increased with the silica content in the composites; on the contrary, the increase of the content of 3-(trimethoxysilyl)propyl methacrylate (TSPA), a coupling agent, decreased the drug release rate.

  10. Ultrasound-guided training in the performance of brachial plexus block by the posterior approach: an observational study.

    NARCIS (Netherlands)

    Geffen, G.J. van; Rettig, H.C.; Koornwinder, T.; Renes, S.; Gielen, M.J.M.

    2007-01-01

    The application of ultrasonography in guiding and controlling the path of the stimulating needle to the brachial plexus via the posterior approach (Pippa technique) was studied. In 21 ASA physical status 1 and 2 patients, scheduled for surgery of the shoulder or upper arm, needle insertion was monit

  11. Virulence Genes among Enterococcus faecalis and Enterococcus faecium Isolated from Coastal Beaches and Human and Nonhuman Sources in Southern California and Puerto Rico

    Directory of Open Access Journals (Sweden)

    Donna M. Ferguson

    2016-01-01

    Full Text Available Most Enterococcus faecalis and E. faecium are harmless to humans; however, strains harboring virulence genes, including esp, gelE, cylA, asa1, and hyl, have been associated with human infections. E. faecalis and E. faecium are present in beach waters worldwide, yet little is known about their virulence potential. Here, multiplex PCR was used to compare the distribution of virulence genes among E. faecalis and E. faecium isolated from beaches in Southern California and Puerto Rico to isolates from potential sources including humans, animals, birds, and plants. All five virulence genes were found in E. faecalis and E. faecium from beach water, mostly among E. faecalis. gelE was the most common among isolates from all source types. There was a lower incidence of asa1, esp, cylA, and hyl genes among isolates from beach water, sewage, septage, urban runoff, sea wrack, and eelgrass as compared to human isolates, indicating that virulent strains of E. faecalis and E. faecium may not be widely disseminated at beaches. A higher frequency of asa1 and esp among E. faecalis from dogs and of asa1 among birds (mostly seagull suggests that further studies on the distribution and virulence potential of strains carrying these genes may be warranted.

  12. Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis.

    Science.gov (United States)

    Yokota, K; Yamashita, A; Oda, M

    1995-06-01

    In this study, we investigated the effects of KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)-thiazol-2-yl]pyrrol-1-ylacetate) , a potent and long-lasting anti-platelet agent, in several experimental thrombosis models and compared them with those of other anti-platelet drugs. Oral administration of KBT-3022 prevented arachidonic acid-induced death due to pulmonary embolism in mice and rabbits with respective ED50 values of 0.29 and 0.12 mg/kg. The protective effect of acetylsalicylic acid (ASA) against mortality was weaker than that of KBT-3022, and ticlopidine hydrochloride (TP) showed no such effect in these models. In a guinea pig arterio-venous shunt model, the inhibition by KBT-3022 of thrombus formation on a silk thread inserted into the shunt was dose-dependent and 300 and 30 times more potent than the inhibition obtained with ASA and indomethacin, respectively. In a model of aortic thrombosis induced by perivascular application of 20% silver nitrate solution, KBT-3022 (1 mg/kg, p.o.) inhibited thrombus formation significantly, ASA (100 mg/kg, p.o.) tended to inhibit it, and TP had no effect. However, in a stasis-induced venous thrombosis model in guinea pigs, TP inhibited thrombus formation significantly, but KBT-3022 and ASA were ineffective. These results suggest that KBT-3022 may be a useful drug for the treatment and/or prophylaxis of thrombus formation in shunts and aortic thrombosis. PMID:7563977

  13. Paksa Badan Sebagai Alternatif Penanganan Terhadap Debitur Yang Beritikad Tidak Baik Dalam Sistem Perbankan Syariah

    OpenAIRE

    Faisal Akbar

    2009-01-01

    Dalam proses pemberian kredit sesuai asas konsesualisme telah terjadi suatu hubungan hukum perikatan antara debitur dan kreditur dimana debitur berkewajiban memberikan prestasi sedang kreditur berhak atas pemenuhan prestasi. Sebaliknya kreditur berkewajiban memberikan prestasi sedang debitur berhak atas pemenuhan prestasi itu pula. Skripsi ini mengemukakan banyaknya bermunculan debitur yang sengaja beritikad tidak baik menghindari kewajibannya. Hal ini sangat berbahaya bagi keperluan investas...

  14. Full charge-density calculation of the surface energy of metals

    DEFF Research Database (Denmark)

    Vitos, Levente; Kollár, J..; Skriver, Hans Lomholt

    1994-01-01

    We have calculated the surface energy and the work function of the 4d metals by means of an energy functional based on a self-consistent, spherically symmetric atomic-sphere potential. In this approach the kinetic energy is calculated completely within the atomic-sphere approximation (ASA) by mea...

  15. Torsion stiffness of a protein pair determined by magnetic particles

    NARCIS (Netherlands)

    Janssen, X.J.A.; Van Noorloos, J.M.; Jacob, A.; Van IJzendoorn, L.J.; De Jong, A.M.; Prins, M.W.J.

    2012-01-01

    We demonstrate the ability to measure torsion stiffness of a proteincomplex by applying a controlled torque on a magnetic particle. Asa model system we use protein G bound to an IgG antibody. The protein pair is held between a magnetic particle and a polystyrene substrate. The angular orientation of

  16. First-Principles Studies the Lattice Constants and the Electronic Structures of Diluted Magnetic Semiconductors (In,Mn)As

    Institute of Scientific and Technical Information of China (English)

    WEI Shuyi; YAN Yuli; XIA Congxin; LIU Guangsheng

    2006-01-01

    Lattice constants and electronic structures of diluted magnetic semiconductors (In,Mn)As were investigated using the first principles LMTO-ASA band calculation by assuming supercell structures. Three concentrations of the 3d impurities were studied (x=1/2, 1/4, 1/8). The effect of varying Mn concentrations on the lattice constants and the electronic structures are shown.

  17. Extraction and structural characteristics of pectic polysaccharides from Abies sibirica L.

    Science.gov (United States)

    Shakhmatov, Evgeny G; Udoratina, Elena V; Atukmaev, Konstantin V; Makarova, Elena N

    2015-06-01

    Structurally different pectins were isolated from the wood greenery of Abies sibirica L. by the sequential extraction with water (ASW), HCl solution (pH∼4) (ASA), and NH3 solution (pH∼8.5) (ASN). The GalA/Rha molar ratios for the ASW (15), ASA (8.9), and ASN (3.9) polysaccharides diminish in the order ASW>ASA>ASN, indicating a decrease in homogalacturonans and increase in rhamnogalacturonan I in this series. The ASWH, ASAH, and ASNH homogalacturonans derived by acid hydrolysis of ASW, ASA, and ASN have similar Mw 23.8, 21.1, and 18.9kDa, respectively, corresponding to a mean polymerization degree of 97-122 for the GalA residue. The macromolecule backbone of ASN was represented mainly by moieties of partially methylesterified homogalacturonan and partially 2-O- and/or 3-O-acetylated rhamnogalacturonan I. The carbohydrate side chains of the branched region are primarily made up of terminal, 1,5-O-, 1,3,5-di-O- and 1,2,3,5-tri-O-substituted α-L-Araf residues and terminal, 1,3-O- and 1,3,6-di-O-substituted β-D-Galp residues. The currently known pectin models were refined. PMID:25843854

  18. Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages

    Directory of Open Access Journals (Sweden)

    Aparecida Donizette Malvezi

    2014-01-01

    Full Text Available The intracellular protozoan parasite Trypanosoma cruzi causes Chagas disease, a serious disorder that affects millions of people in Latin America. Cell invasion by T. cruzi and its intracellular replication are essential to the parasite’s life cycle and for the development of Chagas disease. Here, we present evidence suggesting the involvement of the host’s cyclooxygenase (COX enzyme during T. cruzi invasion. Pharmacological antagonist for COX-1, aspirin (ASA, caused marked inhibition of T. cruzi infection when peritoneal macrophages were pretreated with ASA for 30 min at 37°C before inoculation. This inhibition was associated with increased production of IL-1β and nitric oxide (NO∙ by macrophages. The treatment of macrophages with either NOS inhibitors or prostaglandin E2 (PGE2 restored the invasive action of T. cruzi in macrophages previously treated with ASA. Lipoxin ALX-receptor antagonist Boc2 reversed the inhibitory effect of ASA on trypomastigote invasion. Our results indicate that PGE2, NO∙, and lipoxins are involved in the regulation of anti-T. cruzi activity by macrophages, providing a better understanding of the role of prostaglandins in innate inflammatory response to T. cruzi infection as well as adding a new perspective to specific immune interventions.

  19. Selective treatment of an anterior spinal artery aneurysm with endosaccular coil therapy. Case report.

    Science.gov (United States)

    Lavoie, Pascale; Raymond, Jean; Roy, Daniel; Guilbert, François; Weill, Alain

    2007-05-01

    The authors report the case of a 12-year-old boy with spinal cord arteriovenous malformation (AVM) and an associated anterior spinal artery (ASA) aneurysm treated with selective coil placement in the context of subarachnoid hemorrhage (SAH). The patient presented with headache. Head computed tomography scanning revealed no abnormal findings. The cerebrospinal fluid was sampled and analyzed and a diagnosis of SAH was established. Investigation, including magnetic resonance imaging of the cord as well as cerebral and spinal angiography, revealed a conus medullaris AVM and a saccular aneurysm located on the ASA at the T-11 level. The aneurysm was thought to be responsible for the bleeding. Superselective ASA angiography showed that the aneurysm was at the bifurcation between a large coronal artery supplying the AVM and the ASA. The relation of the aneurysm's neck to the main spinal axis and the aneurysm's morphological features indicated that the lesion was suited for endosaccular coil therapy. The aneurysm was selectively occluded, using electrodetachable bare platinum coils. Follow-up angiography immediately after surgery and at 6 months thereafter demonstrated complete occlusion of the aneurysm and a perfectly patent anterior spinal axis. On clinical follow-up examination, the patient remained neurologically intact. When the morphological features of a spinal aneurysm and its relation with the anterior spinal axis are favorable, selective endosaccular coil placement can successfully be achieved. PMID:17542515

  20. Clinical trial and in-vitro study comparing the efficacy of treating bony lesions with allografts versus synthetic or highly-processed xenogeneic bone grafts

    DEFF Research Database (Denmark)

    Kubosch, Eva Johanna; Bernstein, Anke; Wolf, Laura;

    2016-01-01

    on age, ASA risk classification, BMI, smoking behavior or type of insurance. However, those factors did significantly influence the bony healing rate (p gender and the filling substances employed within the different locations...... without bony healing 3.6 %; neither outcome parameter differed comparing the intervention groups. Failed consolidation correlated with an increase in complications (p 

  1. Effects of active shock avoidance learning on hippocampal neurogenesis and plasma levels of corticosterone

    NARCIS (Netherlands)

    van der Borght, Karin; Meerlo, Peter; Luiten, Paul G.M.; Eggen, Bart J.L.; van der Zee, Eddy A.

    2005-01-01

    Hippocampal granule neurons that are newly formed during adulthood might be involved in learning and memory processes. Experimental data suggest that only hippocampus-dependent learning tasks stimulate neurogenesis. To further address this issue, the effects of active shock avoidance (ASA) learning

  2. The neuroprotection of Aspirin on Cerebral Ischemia-Reperfusion rats

    Institute of Scientific and Technical Information of China (English)

    QiuLi-ying; YuJuan; ChenChong-hong; ZhouYu

    2004-01-01

    AIM: Aspirin (aeetylsalicylic acid, ASA as a nonsteroidal anti-inflammatory drug not only has well-established efficacy in anti-thromboxane, but also has direct neuroprotective effect. In this study, we design to investigate its neuroprotective effect on focal cerebral ischemia-reperfusion injury (CIRI rats, and its effect on ATP level from occluded brain tis-

  3. Defining active sacroiliitis on MRI for classification of axial spondyloarthritis

    DEFF Research Database (Denmark)

    Lambert, Robert G W; Bakker, Pauline A C; van der Heijde, Désirée;

    2016-01-01

    OBJECTIVES: To review and update the existing definition of a positive MRI for classification of axial spondyloarthritis (SpA). METHODS: The Assessment in SpondyloArthritis International Society (ASAS) MRI working group conducted a consensus exercise to review the definition of a positive MRI for...

  4. ASASSN-16hd: Discovery of A Probable Supernova in GALEXASC J015051.89+223348.8

    Science.gov (United States)

    Brown, J. S.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Godoy-Rivera, D.; Basu, U.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Chen, Ping; Brimacombe, J.

    2016-07-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Brutus" telescope in Haleakala, Hawaii, we discovered a new transient source, most likely a supernova, in the galaxy GALEXASC J015051.89+223348.8.

  5. ASASSN-16hh: Discovery of A Probable Supernova in MCG +03-06-031

    Science.gov (United States)

    Nicolas, J.; Kiyota, S.; Brown, J. S.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Godoy-Rivera, D.; Basu, U.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Chen, Ping; Brimacombe, J.; Masi, G.; Post, R. S.; Stone, G.

    2016-07-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Brutus" telescope in Haleakala, Hawaii, we discovered a new transient source, most likely a supernova, in the galaxy MCG +03-06-031.

  6. ASASSN-16hc: Discovery of A Probable Supernova in 2MASX J13590394+3308172

    Science.gov (United States)

    Masi, G.; Brown, J. S.; Holoien, T. W.-S.; Stanek, K. Z.; Kochanek, C. S.; Godoy-Rivera, D.; Basu, U.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Chen, Ping; Brimacombe, J.; Bock, G.; Kiyota, S.; Post, R. S.; Stone, G.

    2016-07-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Brutus" telescope in Haleakala, Hawaii, we discovered a new transient source, most likely a supernova, in the galaxy 2MASX J13590394+3308172.

  7. Chirurgische dilemma’s. Medische beperkingen en risicofactoren

    NARCIS (Netherlands)

    Meijer, G.J.; Cune, M.S.

    2008-01-01

    In principle, only patients with an ASA (American Society of Anaesthesiologists)-score I or II qualify for an elective surgical procedure, such as an implantation treatment. Surgical risks are weighed against the potential benefits offered by oral implants. Counter-indications to implant rehabilitat

  8. Exploring Innovation Processes from a Complexity Perspective. Part II. Experiences from the Subsea Increased Oil Recovery Case

    Science.gov (United States)

    Aasen, Tone Merethe Berg; Johannessen, Stig

    2007-01-01

    In this second part of the papers, exploring innovation processes from a complexity perspective, we present an empirical example to strengthen further the relevance of the approach. The example draws on a longitudinal research initiative conducted in cooperation with the Norwegian petroleum company Statoil ASA. We conducted our research into the…

  9. Responses of antioxidant defense system of Lespedeza davurica to enhanced UV-B radiation

    International Nuclear Information System (INIS)

    The objective of this study was to investigate the effects of different UV-B radiation intensity (CK, T1, T2) on antioxidant defense system and other related indicators of Lespedeza davurica (Laxm.) Schindl. Malonaldehyde (MDA), ascorbic acid (AsA) and carotenoid (Car) contents, as well as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) and ascorbate peroxidase (APX) activities of leaves from Lespedeza davurica under different UV-B radiation intensity were investigated. Samples were collected once every three days. The UV-B treatment was continued 15 days. Result indicated that SOD and POD activities decreased, APX and POD activities increased with UV-B radiation enhanced during the whole treatment time. SOD, POD and CAT activities decreased with UV-B radiation intensity increasing. APX activity increased during the first 9-day treatment with radiation intensity increasing then decreased with radiation intensity increasing. UV-B radiation increased AsA content, decreased Car content. Both AsA and Car contents decreased with radiation intensity increasing when compared with control. O2- and MDA increased with radiation intensity increasing. All other tested indicators increased except SOD and POD activity as well as AsA content decreased after UV-B radiation treatment. Comprehensive evaluation of subordinate function showed that UV-B radiation reduced the antioxidant capacity of Lespedeza davurica, and the antioxidant capacity decreased with UV-B radiation intensity increasing. (author)

  10. Possible interactions between dietary fibres and 5-aminosalicylic acid [corrected

    DEFF Research Database (Denmark)

    Henriksen, Camilla; Hansen, Steen Honoré; Nordgaard-Lassen, Inge;

    2010-01-01

    fibres is related to disease activity in patients with ulcerative colitis (UC) treated with 5-ASA. METHODS: In vitro: 15 g of Ispaghula Husk, wheat bran, citrus-pectin, or wheat flour were incubated in a 37°C buffered solutions of 5-ASA (1 g/l) for 3 hours at pH 6 and 7. The concentrations of 5-ASA were...... determined before and after the incubation using HPLC. In vivo: patients with UC were interviewed two to three times during 6 months. The fibre consumption was estimated and related to the disease activity (CAI, CRP, Faecal-calprotectin) and quality of life (IBDQ). RESULTS: In vitro: 5-ASA was bound...... to Ispaghula Husk (5.3-10.0 mg/g) and wheat bran (4.6-5.5 mg/g), and to a minor degree to citrus-pectin. No differences were found in relation to pH. In vivo: 29 patients completed the scheduled interviews. No significant changes in fibre consumption were observed over time; however, patients consuming a diet...

  11. A comparison of cardiac rate-pressure product and pressure-rate quotient in healthy and medically compromised patients.

    Science.gov (United States)

    Campbell, R L; Langston, W G

    1995-08-01

    Healthy and medically compromised patients were studied to compare blood pressure and heart rate changes in response to stress of routine dental extractions performed while they were under local anesthesia. Thirty-nine patients divided into American Society of Anesthesiologists (ASA) I and II groups were noninvasively monitored every 5 minutes. Systolic, diastolic, and mean arterial pressures and heart rate were recorded. Rate pressure products (RPP) and pressure rate (PRQ) quotients were calculated and compared in each group. Significant results were measures of RPP greater than 12,000 and PRQ less than one. Of the 24 patients in the ASA I category, 50% demonstrated elevated RPP values, but only two of 24 had coincidental PRQ abnormalities. Of the 15 patients in the ASA II category, 80% demonstrated elevated RPP values, but two of 15 had coincidental PRQ abnormalities. Patients in the ASA II category had a higher incidence of RPP and PRQ abnormalities, as was expected. However, it is not known which of these two measures is a more sensitive indicator of increased risk associated with stimulation of the sympathetic-adrenergic axis during oral surgery performed with patients under local anesthesia. Correlation studies with continuous Holter monitoring for ST-T wave changes on electrocardiography are forthcoming. PMID:7552876

  12. Self-assembly and emulsification properties of hydrophobically modified inulin.

    Science.gov (United States)

    Han, Lingyu; Ratcliffe, Ian; Williams, Peter A

    2015-04-15

    A series of alkenylated inulin samples were synthesized in aqueous solution using alkenyl succinic anhydrides with varying alkenyl chain lengths (C8-C18). The inulin derivatives (ASA-inulins) were characterized using NMR and FTIR and their degree of substitution determined. The solution properties of ASA-inulins were investigated using dye solubilization, surface tension, and dynamic light scattering, and all three techniques confirmed that the molecules aggregated in solution above a critical concentration (critical aggregation concentration, CAC). The value of the CAC was found to be reasonably consistent between the different techniques and was shown to decrease with increasing alkenyl chain length, from 0.08% for the octenyl succinylated sample to 0.005% for the octadecenyl succinylated sample. The hydrodynamic diameter of ASA-inulins above the CAC was determined from dynamic light scattering studies and was shown to increase with alkenyl chain length, from 4 nm for the octenyl derivative to 55 nm for the hexadecenyl derivative. All ASA-inulins were shown to be able to produce oil-in-water emulsions with a droplet size similar to that of emulsions prepared using Tween 20 on storing for 21 days. The fact that the derivatives are able to form micellarlike aggregates and stabilize emulsions makes them suitable candidates for the encapsulation and delivery of water-insoluble active compounds, with potential application in food, cosmetic, personal care, and pharmaceutical formulations.

  13. Algebra for Babies: Exploring Natural Numbers in Simple Arrays. Occasional Paper Five

    Science.gov (United States)

    Fluellen, Jerry E., Jr.

    2008-01-01

    In 12 audio taped sessions, three kindergarten children engaged algebra in a teaching for understanding, thematic project. Toni, Asa, and Cornel had one-on-one lessons dealing with simple natural numbers, patterns, and relationships. Along the way, each child studied one of Toni Morrison's Who's got game books to explore repetition patterns in…

  14. Fine Woodworking Magazine editor to speak Sept. 4

    OpenAIRE

    Davis, Lynn

    2007-01-01

    Asa Christiana, editor of Fine Woodworking magazine published by Taunton Press, will kick-off Wood Week 2007 activities at Virginia Tech with a public lecture "The Science and Artistry of Fine Furniture," Tuesday Sept. 4, at 7 p.m. in the Auditorium of the Fralin Building on the Virginia Tech campus.

  15. In situ catalytic pyrolysis of lignocellulose using alkali-modified amorphous silica alumina

    NARCIS (Netherlands)

    Zabeti, M.; Nguyen, T. S.; Lefferts, L.; Heeres, H. J.; Seshan, K.

    2012-01-01

    Canadian pinewood was pyrolyzed at 450 degrees C in an Infrared oven and the pyrolysis vapors were converted by passing through a catalyst bed at 450 degrees C. The catalysts studied were amorphous silica alumina (ASA) containing alkali metal or alkaline earth metal species including Na, K, Cs, Mg a

  16. Esomeprazole for prevention and resolution of upper gastrointestinal symptoms in patients treated with low-dose acetylsalicylic acid for cardiovascular protection: the OBERON trial.

    Science.gov (United States)

    Scheiman, James M; Herlitz, Johan; Veldhuyzen van Zanten, Sander J; Lanas, Angel; Agewall, Stefan; Nauclér, Emma C; Svedberg, Lars-Erik; Nagy, Péter

    2013-03-01

    Although low-dose acetylsalicylic acid (ASA) is recommended for prevention of cardiovascular events in at-risk patients, its long-term use can be associated with the risk of peptic ulcer and upper gastrointestinal (GI) symptoms that may impact treatment compliance. This prespecified secondary analysis of the OBERON study (NCT00441727) determined the efficacy of esomeprazole for prevention/resolution of low-dose ASA-associated upper GI symptoms. A post hoc analysis of predictors of symptom prevention/resolution was also conducted. Helicobacter pylori-negative patients taking low-dose ASA (75-325 mg) for cardiovascular protection who had ≥1 upper GI risk factor were eligible. The patients were randomized to once-daily esomeprazole 40 mg, 20 mg, or placebo, for 26 weeks; 2303 patients (mean age 67.6 years; 36% aged >70 years) were evaluable for upper GI symptoms. The proportion of patients with dyspeptic or reflux symptoms (self-reported Reflux Disease Questionnaire) was significantly lower (P 70 years (P symptoms at baseline (P prevention/resolution of upper GI symptoms. Together, these analyses demonstrate that esomeprazole is effective in preventing and resolving patient-reported upper GI symptoms in low-dose ASA users at increased GI risk.

  17. Occupational exposure in patients with the antisynthetase syndrome.

    NARCIS (Netherlands)

    Labirua-Iturburu, A.; Selva-O'Callaghan, A.; Zock, J.P.; Orriols, R.; Martinez-Gómez, X.; Vilardell-Tarrés, M.

    2014-01-01

    Interstitial lung disease (ILD) is common in patients with myositis and is related with the presence of antisynthetase autoantibodies (aSA). Together with other manifestations, the resulting condition is known as the antisynthetase syndrome (ASS). Contact with certain environmental and occupational

  18. Asiago spectroscopic classification of two SNe

    Science.gov (United States)

    Benetti, S.; Cappellaro, E.; Elias-Rosa, N.; Ochner, P.; Pastorello, A.; Terreran, G.; Tomasella, L.; OAPd, M. Turatto (INAF

    2016-09-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic classification of two transients. The targets are supplied by the All Sky Automated Survey for SuperNOvae (ASAS-SN) and the TNS (https://wis-tns.weizmann.ac.il).

  19. Studies on the relationship between the changes of the endogenous scavengers of active oxygen and resistance in hybrid rice under temperature stress

    Institute of Scientific and Technical Information of China (English)

    FANShuyang; GUOShaochuan

    1994-01-01

    The seedlings of indica hybrid rice Weiyou 49 and Weiyou 28 were exposed to 1℃ and 40℃ .and the changes of activity (content) of superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), ascorbic acid (ASA), glutathione (GSH),malondialdehyde (MDA) and leakage of electrolytes (%) were measured.

  20. Cognitive Laboratory Experiences : On Pre-testing Computerised Questionnaires

    NARCIS (Netherlands)

    Snijkers, G.J.M.E.

    2002-01-01

    In the literature on questionnaire design and survey methodology, pre-testing is mentioned as a way to evaluate questionnaires (i.e. investigate whether they work as intended) and control for measurement errors (i.e. assess data quality). As the American Statistical Association puts it (ASA, 1999, p