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Sample records for arvi freiberg ku

  1. Arvi Tavast - mees keset keele- ja teenetemärke / Arvi Tavast ; intervjueerinud Tanel Veenre

    Index Scriptorium Estoniae

    Tavast, Arvi, 1969-

    2010-01-01

    Vestlus tõlkija ja Tallinna Ülikooli kirjaliku tõlke dotsendi Arvi Tavastiga Roman Tavasti juveelifirmast, mis valmistab olulise osa presidendi annetatavatest riiklikest teenetemärkidest. Arvi Tavasti doktoritööst "The translator is human too: a case for instrumentalism in multilingual specialised communication" (Tartu : Tartu University Press, c2008)

  2. Assessment of reactor vessel integrity (ARVI)

    Energy Technology Data Exchange (ETDEWEB)

    Sehgal, B.R. E-mail: sehgal@ne.kth.se; Theerthan, A.; Giri, A.; Karbojian, A.; Willschuetz, H.G.; Kymaelaeinen, O.; Vandroux, S.; Bonnet, J.M.; Seiler, J.M.; Ikkonen, K.; Sairanen, R.; Bhandari, S.; Buerger, M.; Buck, M.; Widmann, W.; Dienstbier, J.; Techy, Z.; Kostka, P.; Taubner, R.; Theofanous, T.; Dinh, T.N

    2003-04-01

    The cost-shared project ARVI (assessment of reactor vessel integrity) involves a total of nine organisations from Europe and USA. The objective of the ARVI Project is to resolve the safety issues that remain unresolved for the melt vessel interaction phase of the in-vessel progression of a severe accident. The work consists of experiments and analysis development. Four tests were performed in the EC-FOREVER Programme, in which failure was achieved in-vessels employing the French pressure vessel steel. The tests were analysed with the commercial code ANSYS-Multiphysics, and the codes SYSTUS+ and PASULA, and quite good agreement was achieved for the failure location. Natural convection experiments in stratified pools have been performed in the SIMECO and the COPO facilities, which showed that much greater heat is transferred downwards for immiscible layers or before layers mix. A model for gap cooling and a set of simplified models for the system codes have been developed. MVITA code calculations have been performed for the Czech and Hungarian VVERs, towards evaluation of the in-vessel melt retention accident management scheme. Tests have been performed at the ULPU facility with organised flow for vessel external cooling. Considerable enhancement of the critical heat flux (CHF) was obtained. The ARVI Project has reached the halfway stage. This paper presents the results obtained thus far from the project.

  3. Surgical treatment of advanced stage Freiberg disease

    Directory of Open Access Journals (Sweden)

    Emin Özkul

    2014-09-01

    Full Text Available Objective: Freiberg disesase is an avascular necrosis of the 2nd and 3rd metatarsal head and which kind of surgical option to be used is controversial in symptomatic patients. In this study the results of the advanced stage Freiberg’s disease patients, who were treated with surgery were evaluated. Methods: 12 patients (8 female, 4 male whose pain could not be solved with conservative method and underwent surgery (6 debridement, 3 osteotomy, 3 excision of the metatarsal head were included in this study. Themean age of the patients 19.1 (range 13- 31 and the mean follow-up 30.8(range 25-94 months. According to the Smillie classification 3 patients had type 5, 8 patients had type 4 and 1 patient had type 3 osteonecrosis. The results of the patients were evaluated according to Lesser Metatarsophalangeal-Interphalangeal Scale. Results: According to Lesser MetatarsophalangealInterphalangeal Scale 3 patients (%25 had excellent, 6 patients (%50 had good and 3 patients had poor results were obtained. 2 of 3 patients with poor results were type 5, and 1 patient was type 4 and all three patients underwent joint debridement. Conclusion:The method of surgical treatment of Freiberg disease determined according to the stage of the disease. Debridement alone in the treatment of patients with late stage is not enough, it should be combined with other methods.

  4. Assessment of reactor vessel integrity (ARVI)

    Energy Technology Data Exchange (ETDEWEB)

    Sehgal, B.R. [Division of Nuclear Power Safety (NPS), Royal Institute of Technology (KTH), Drottning Kristinas Vaeg 33A, 10044 Stockholm (Sweden)]. E-mail: sehgal@ne.kth.se; Karbojian, A. [Division of Nuclear Power Safety (NPS), Royal Institute of Technology (KTH), Drottning Kristinas Vaeg 33A, 10044 Stockholm (Sweden); Giri, A. [Division of Nuclear Power Safety (NPS), Royal Institute of Technology (KTH), Drottning Kristinas Vaeg 33A, 10044 Stockholm (Sweden); Kymaelaeinen, O. [FortumEngNP (Finland); Bonnet, J.M. [CEA (France); Ikkonen, K. [Division of Nuclear Power Safety (NPS), Royal Institute of Technology (KTH), Drottning Kristinas Vaeg 33A, 10044 Stockholm (Sweden); Sairanen, R. [VTT (Finland); Bhandari, S. [FRAMATOME (France); Buerger, M. [USTUTT (Germany); Dienstbier, J. [NRI Rez (Czech Republic); Techy, Z. [VEIKI (Hungary); Theofanous, T. [UCSB (United States)

    2005-02-01

    The assessment of reactor vessel integrity (ARVI) project involved a total of nine organizations from Europe and USA. The work consisted of experiments and analysis development. The modeling activities in the area of structural analyses were focused on the support of EC-FOREVER experiments as well as on the exploitation of the data obtained from those experiments for modeling of creep deformation and the validation of the industry structural codes. Work was also performed for extension of melt natural convection analyses to consideration of stratification, and mixing (in the CFD codes). Other modeling activities were for (1) gap cooling CHF and (2) developing simple models for system code. Finally, the methodology and data was applied for the design of IVMR severe accident management scheme for VVER-440/213 plants. The work was broken up into five packages. They were divided into tasks, which were performed by different partners. The major experimental project continued was EC-FOREVER in which data was obtained on in-vessel melt pool coolability. In previous EC-FOREVER experiments data was obtained on melt pool natural convection and lower head creep failure and rupture. Those results obtained were related to the following issues: (1) multiaxial creep laws for different vessel steels (2) effects of penetrations, and (3) mode and location of lower head failure. The two EC-FOREVER tests reported here are related to (a) the effectiveness of gap cooling and (b) water ingression for in vessel melt coolability. Two other experimental projects were also conducted. One was the COPO experiments, which was concerned with the effects of stratification and metal layer on the thermal loads on the lower head wall during melt pool convection. The second experimental project was conducted at ULPU facility, which provided data and correlations of CHF due to the external cooling of the lower head.

  5. Arvi Hamburg : rumal arst võib tappa korraga ühe inimese, rumal insener tuhandeid / Arvi Hamburg ; interv. Taivo Paju

    Index Scriptorium Estoniae

    Hamburg, Arvi, 1948-

    2008-01-01

    Eesti Inseneride Liidu president Arvi Hamburg annab lühiülevaate insenerides arvukusest ja kutsekvalifikatsioonist. Projekt tehnikahariduse ja insenerikutse populaarsuse tõstmiseks. Vt. samas: Lühiülevaade inseneri kutseala kvalifikatsioonitasemetest

  6. Early detection of Freiberg's disease by radionuclide bone imaging

    International Nuclear Information System (INIS)

    Peng Jingjing

    1993-01-01

    56 hallux valgus deformities of 28 patients were studied with radionuclide bone imaging (RNBI). Among them, 24 feet(42.85%) revealed increased uptake of radioactivity in second or third metatarsal. The ratio of radioactivity in lesion and contralateral normal site (D/N) was increased, the difference between the patient and normal groups was significant (P<0.01). The histologic study showed that there have been degenerative changes and bone cell necrosis in increased uptake area. It was concluded that RNBI was more sensitive than X ray and can be used for the early diagnosis of Freiberg's Disease

  7. Experiences gained by establishing the IAMG Student Chapter Freiberg

    Science.gov (United States)

    Ernst, Sebastian M.; Liesenberg, Veraldo; Shahzad, Faisal

    2013-04-01

    The International Association for Mathematical Geosciences (IAMG) Student Chapter Freiberg was founded in 2007 at the Technische Universität Bergakademie Freiberg (TUBAF) in Germany by national and international graduate and undergraduate students of various geoscientific as well as natural science disciplines. The major aim of the IAMG is to promote international cooperation in the application and use of Mathematics in Geosciences research and technology. The IAMG encourages all types of students and young scientists to found and maintain student chapters, which can even receive limited financial support by the IAMG. Following this encouragement, generations of students at TUBAF have build up and established a prosperous range of activities. These might be an example and an invitation for other young scientists and institutions worldwide to run similar activities. We, some of the current and former students behind the student chapter, have organised talks, membership drives, student seminars, guest lectures, several short courses and even international workshops. Some notable short courses were held by invited IAMG distinguished lecturers. The topics included "Statistical analysis in the Earth Sciences using R - a language and environment for statistical computing and graphics", "Geomathematical Natural Resource Modeling" and "Introduction to Geostatistics for Environmental Applications and Natural Resources Evaluation: Basic Concepts and Examples". Furthermore, we conducted short courses by ourselves. Here, the topics included basic introductions into MATLAB, object oriented programming concepts for geoscientists using MATLAB and an introduction to the Keyhole Markup Language (KML). Most of those short courses lasted several days and provided an excellent and unprecedented teaching experience for us. We were given credit by attending students for filling gaps in our university's curriculum by providing in-depth and hands-on tutorials on topics, which were merely

  8. Er KU et mobbeuniversitet?

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2009-01-01

    Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende.......Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende....

  9. [Isolation of the cercaria Diplostomum phoxini (Faust, 1918) Arvy et Buttner, 1954 (Diplostomatidae) from fresh water mollusks of the Crimea].

    Science.gov (United States)

    Sten'ko, R P

    1976-01-01

    Data on the biology and morphology of cercariae of Diplostomum phoxini (Faust, 1918) Arvy et Buttner, 1954 are given. The cercariae were found in Radix auricularia from the middle part of the Burulcha river (Ukranian SSR, Crimea). In November, 1974 the invasion extensity of mollusks was 16.3%. No cercariae were found in spring and summer samples.

  10. Pametna kuća

    OpenAIRE

    Rade, Sanjin

    2015-01-01

    Uslijed ubrzanog napretka u bežičnoj komunikaciji i informacijskim tehnologijama, sada je moguće uvesti i implementirati različite razine „pametnosti“ u kuće. Ove pametne kuće su kuće koje mogu da se inteligentno uključe u razne interakcije sa svojim stanovnicima da bi im omogućile udobnost i siguran život. Ovo uključivanje u živote svojih stanara može varirati od jednostavne kontrole ambijentne temperature do ispunjavanja usluga koje su zasnovane na mobilnim agentima. Pametne kuće imaju ...

  11. CLINICAL EVIDENCE OF THE EFFECTIVENESS OF VIFERON® MEDICATIONS IN THE TREATMENT OF ARVI AND INFLUENZA IN ADULTS

    Directory of Open Access Journals (Sweden)

    V. V. Malinovskaya

    2014-01-01

    Full Text Available The paper presents a comparative analysis of the results of clinical laboratory trials carried out on the basis of 10 different medical and preventive treatment facilities drawing on the principles and methodology of evidence-based medicine, which confirmed the certainty of clinical effectiveness of Viferon® medications in the treatment of acute respiratory viral infections (ARVI and influenza in adults. The algorithm included an assessment of antiviral, immunomodulatory, anti-inflammatory, anti-oxidant actions of the medication under the conditions of concurrent, unmasked, randomized, placebo-controlled, clinical immunological studies and a retrospective analysis in keeping with the “Guidelines for Good Clinical Practice”. Thereby, it was shown that the use of Viferon® medications (suppositories, gel in the treatment of adults with influenza and ARVI, whether with viral or viral-bacterial etiology, contributes to a statistically significant reduction in duration of principal clinical symptoms and the disease as a whole, as well as a decrease of immune and interferon system imbalance and a faster elimination of viral antigens. On the basis of the proven antiviral therapeutic effectiveness and immunomodulatory action, safety and high tolerability, easy-to-administer form in the  outpatient settings, Viferon® has been recommended as a disease-modifying agent in the treatment of influenza and ARVI in adults.

  12. Estimation of Epidemiological Effectiveness of the Program of Pharmaceutical Prevention of Influenza and ARVI «Antigripp» in Organized Children's Groups

    Directory of Open Access Journals (Sweden)

    I. B. Yakovlev

    2012-01-01

    Full Text Available The authors estimated epidemiological effectiveness of the program for prophylaxis of influenza and ARVI «Antigripp» for children of 7—12 years old. Children received Arbidol (capsules of 100 mg 2 times a week for 3 weeks and Complivit activ. As a result there was a decline in absolute and relative indicators of ARVI morbidity risks. Epidemiological effectiveness of the program during the application of the drugs made up 56% and index of preventive efficacy was 2,3.

  13. Identification and analysis of Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae.

    Science.gov (United States)

    Takahashi, Tadashi; Masuda, Tsutomu; Koyama, Yasuji

    2006-01-01

    Ku genes play a key role in the non-homologous end-joining pathway. We have identified Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae, and have constructed the disruption mutants of Ku70, Ku80, and Ku70-80 to characterize the phenotypic change in these mutants. Neither Ku70- nor Ku80-disrupted strains show hypersensitivity to the DNA damaging agents methylmethane sulfonate (MMS) and phleomycin. Moreover, undesirable phenotypes, such as poor growth or repressed conidiospore formation, were not observed in the Ku-disrupted A. sojae and A. oryzae.

  14. Molecular analysis of Ku redox regulation

    Directory of Open Access Journals (Sweden)

    Shatilla Andrea

    2009-08-01

    Full Text Available Abstract Background DNA double-strand breaks (DSBs can occur in response to ionizing radiation (IR, radiomimetic agents and from endogenous DNA-damaging reactive oxygen metabolites. Unrepaired or improperly repaired DSBs are potentially the most lethal form of DNA damage and can result in chromosomal translocations and contribute to the development of cancer. The principal mechanism for the repair of DSBs in humans is non-homologous end-joining (NHEJ. Ku is a key member of the NHEJ pathway and plays an important role in the recognition step when it binds to free DNA termini. Ku then stimulates the assembly and activation of other NHEJ components. DNA binding of Ku is regulated by redox conditions and evidence from our laboratory has demonstrated that Ku undergoes structural changes when oxidized that results in a reduction in DNA binding activity. The C-terminal domain and cysteine 493 of Ku80 were investigated for their contribution to redox regulation of Ku. Results We effectively removed the C-terminal domain of Ku80 generating a truncation mutant and co-expressed this variant with wild type Ku70 in an insect cell system to create a Ku70/80ΔC heterodimer. We also generated two single amino acid variants of Cys493, replacing this amino acid with either an alanine (C493A or a serine (C493S, and over-expressed the variant proteins in SF9 insect cells in complex with wild type Ku70. Neither the truncation nor the amino acid substitutions alters protein expression or stability as determined by SDS-PAGE and Western blot analysis. We show that the C493 mutations do not alter the ability of Ku to bind duplex DNA in vitro under reduced conditions while truncation of the Ku80 C-terminus slightly reduced DNA binding affinity. Diamide oxidation of cysteines was shown to inhibit DNA binding similarly for both the wild-type and all variant proteins. Interestingly, differential DNA binding activity following re-reduction was observed for the Ku70/80

  15. Karikaturist Aivar Juhanson näitab KuKu klubis oma töid

    Index Scriptorium Estoniae

    2009-01-01

    Loit Jõekalda kureeritud joonistustriennaali raames eksponeerivad oma töid Ave Avalo, Kärt Hammer, Eero Ijavoinen, Kristjan Kittus, Mari-Liis Laanemaa, Triinu Lille, Valli Lember-Bogatkina jpt. kunstnikud. Ajalehe "Eesti Ekspress" karikaturisti Aivar Juhansoni tööde näitus Tallinnas KuKu klubis

  16. Characterization of Three Different Unusual S-Layer Proteins from Viridibacillus arvi JG-B58 That Exhibits Two Super-Imposed S-Layer Proteins

    Science.gov (United States)

    Günther, Tobias J.; Raff, Johannes; Pollmann, Katrin

    2016-01-01

    Genomic analyses of Viridibacillus arvi JG-B58 that was previously isolated from heavy metal contaminated environment identified three different putative surface layer (S-layer) protein genes namely slp1, slp2, and slp3. All three genes are expressed during cultivation. At least two of the V. arvi JG-B58 S-layer proteins were visualized on the surface of living cells via atomic force microscopy (AFM). These S-layer proteins form a double layer with p4 symmetry. The S-layer proteins were isolated from the cells using two different methods. Purified S-layer proteins were recrystallized on SiO2 substrates in order to study the structure of the arrays and self-assembling properties. The primary structure of all examined S-layer proteins lack some features that are typical for Bacillus or Lysinibacillus S-layers. For example, they possess no SLH domains that are usually responsible for the anchoring of the proteins to the cell wall. Further, the pI values are relatively high ranging from 7.84 to 9.25 for the matured proteins. Such features are typical for S-layer proteins of Lactobacillus species although sequence comparisons indicate a close relationship to S-layer proteins of Lysinibacillus and Bacillus strains. In comparison to the numerous descriptions of S-layers, there are only a few studies reporting the concomitant existence of two different S-layer proteins on cell surfaces. Together with the genomic data, this is the first description of a novel type of S-layer proteins showing features of Lactobacillus as well as of Bacillus-type S-layer proteins and the first study of the cell envelope of Viridibacillus arvi. PMID:27285458

  17. Ku80-deleted cells are defective at base excision repair

    International Nuclear Information System (INIS)

    Li, Han; Marple, Teresa; Hasty, Paul

    2013-01-01

    Graphical abstract: - Highlights: • Ku80-deleted cells are hypersensitive to ROS and alkylating agents. • Cells deleted for Ku80, but not Ku70 or Lig4, have reduced BER capacity. • OGG1 rescues hypersensitivity to H 2 O 2 and paraquat in Ku80-mutant cells. • Cells deleted for Ku80, but not Lig4, are defective at repairing AP sites. • Cells deleted for Ku80, but not Lig4 or Brca2 exon 27, exhibit increased PAR. - Abstract: Ku80 forms a heterodimer with Ku70, called Ku, that repairs DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway. As a consequence of deleting NHEJ, Ku80-mutant cells are hypersensitive to agents that cause DNA DSBs like ionizing radiation. Here we show that Ku80 deletion also decreased resistance to ROS and alkylating agents that typically cause base lesions and single-strand breaks (SSBs). This is unusual since base excision repair (BER), not NHEJ, typically repairs these types of lesions. However, we show that deletion of another NHEJ protein, DNA ligase IV (Lig4), did not cause hypersensitivity to these agents. In addition, the ROS and alkylating agents did not induce γ-H2AX foci that are diagnostic of DSBs. Furthermore, deletion of Ku80, but not Lig4 or Ku70, reduced BER capacity. Ku80 deletion also impaired BER at the initial lesion recognition/strand scission step; thus, involvement of a DSB is unlikely. Therefore, our data suggests that Ku80 deletion impairs BER via a mechanism that does not repair DSBs

  18. Ku80-deleted cells are defective at base excision repair

    Energy Technology Data Exchange (ETDEWEB)

    Li, Han [The University of Texas Health Science Center at San Antonio, The Institute of Biotechnology, The Department of Molecular Medicine, 15355 Lambda Drive, San Antonio, TX 78245-3207 (United States); Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029 (Spain); Marple, Teresa [The University of Texas Health Science Center at San Antonio, The Institute of Biotechnology, The Department of Molecular Medicine, 15355 Lambda Drive, San Antonio, TX 78245-3207 (United States); Hasty, Paul, E-mail: hastye@uthscsa.edu [The University of Texas Health Science Center at San Antonio, The Institute of Biotechnology, The Department of Molecular Medicine, 15355 Lambda Drive, San Antonio, TX 78245-3207 (United States); Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029 (Spain)

    2013-05-15

    Graphical abstract: - Highlights: • Ku80-deleted cells are hypersensitive to ROS and alkylating agents. • Cells deleted for Ku80, but not Ku70 or Lig4, have reduced BER capacity. • OGG1 rescues hypersensitivity to H{sub 2}O{sub 2} and paraquat in Ku80-mutant cells. • Cells deleted for Ku80, but not Lig4, are defective at repairing AP sites. • Cells deleted for Ku80, but not Lig4 or Brca2 exon 27, exhibit increased PAR. - Abstract: Ku80 forms a heterodimer with Ku70, called Ku, that repairs DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway. As a consequence of deleting NHEJ, Ku80-mutant cells are hypersensitive to agents that cause DNA DSBs like ionizing radiation. Here we show that Ku80 deletion also decreased resistance to ROS and alkylating agents that typically cause base lesions and single-strand breaks (SSBs). This is unusual since base excision repair (BER), not NHEJ, typically repairs these types of lesions. However, we show that deletion of another NHEJ protein, DNA ligase IV (Lig4), did not cause hypersensitivity to these agents. In addition, the ROS and alkylating agents did not induce γ-H2AX foci that are diagnostic of DSBs. Furthermore, deletion of Ku80, but not Lig4 or Ku70, reduced BER capacity. Ku80 deletion also impaired BER at the initial lesion recognition/strand scission step; thus, involvement of a DSB is unlikely. Therefore, our data suggests that Ku80 deletion impairs BER via a mechanism that does not repair DSBs.

  19. Inhibition of Ku70 acetylation by INHAT subunit SET/TAF-Iβ regulates Ku70-mediated DNA damage response.

    Science.gov (United States)

    Kim, Kee-Beom; Kim, Dong-Wook; Park, Jin Woo; Jeon, Young-Joo; Kim, Daehwan; Rhee, Sangmyung; Chae, Jung-Il; Seo, Sang-Beom

    2014-07-01

    DNA double-strand breaks (DSBs) can cause either cell death or genomic instability. The Ku heterodimer Ku70/80 is required for the NHEJ (non-homologous end-joining) DNA DSB repair pathway. The INHAT (inhibitor of histone acetyltransferases) complex subunit, SET/TAF-Iβ, can inhibit p300- and PCAF-mediated acetylation of both histone and p53, thereby repressing general transcription and that of p53 target genes. Here, we show that SET/TAF-Iβ interacts with Ku70/80, and that this interaction inhibits CBP- and PCAF-mediated Ku70 acetylation in an INHAT domain-dependent manner. Notably, DNA damage by UV disrupted the interaction between SET/TAF-Iβ and Ku70. Furthermore, we demonstrate that overexpressed SET/TAF-Iβ inhibits recruitment of Ku70/80 to DNA damage sites. We propose that dysregulation of SET/TAF-Iβ expression prevents repair of damaged DNA and also contributes to cellular proliferation. All together, our findings indicate that SET/TAF-Iβ interacts with Ku70/80 in the nucleus and inhibits Ku70 acetylation. Upon DNA damage, SET/TAF-Iβ dissociates from the Ku complex and releases Ku70/Ku80, which are then recruited to DNA DSB sites via the NHEJ DNA repair pathway.

  20. A moonlighting function of Mycobacterium smegmatis Ku in zinc homeostasis?

    Science.gov (United States)

    Kushwaha, Ambuj K; Deochand, Dinesh K; Grove, Anne

    2015-02-01

    Ku protein participates in DNA double-strand break repair via the nonhomologous end-joining pathway. The three-dimensional structure of eukaryotic Ku reveals a central core consisting of a β-barrel domain and pillar and bridge regions that combine to form a ring-like structure that encircles DNA. Homologs of Ku are encoded by a subset of bacterial species, and they are predicted to conserve this core domain. In addition, the bridge region of Ku from some bacteria is predicted from homology modeling and sequence analyses to contain a conventional HxxC and CxxC (where x is any residue) zinc-binding motif. These potential zinc-binding sites have either deteriorated or been entirely lost in Ku from other organisms. Using an in vitro metal binding assay, we show that Mycobacterium smegmatis Ku binds two zinc ions. Zinc binding modestly stabilizes the Ku protein (by ∼3°C) and prevents cysteine oxidation, but it has little effect on DNA binding. In vivo, zinc induces significant upregulation of the gene encoding Ku (∼sixfold) as well as a divergently oriented gene encoding a predicted zinc-dependent MarR family transcription factor. Notably, overexpression of Ku confers zinc tolerance on Escherichia coli. We speculate that zinc-binding sites in Ku proteins from M. smegmatis and other mycobacterial species have been evolutionarily retained to provide protection against zinc toxicity without compromising the function of Ku in DNA double-strand break repair. © 2014 The Protein Society.

  1. Mycobacterium smegmatis Ku binds DNA without free ends.

    Science.gov (United States)

    Kushwaha, Ambuj K; Grove, Anne

    2013-12-01

    Ku is central to the non-homologous end-joining pathway of double-strand-break repair in all three major domains of life, with eukaryotic homologues being associated with more diversified roles compared with prokaryotic and archaeal homologues. Ku has a conserved central 'ring-shaped' core domain. While prokaryotic homologues lack the N- and C-terminal domains that impart functional diversity to eukaryotic Ku, analyses of Ku from certain prokaryotes such as Pseudomonas aeruginosa and Mycobacterium smegmatis have revealed the presence of distinct C-terminal extensions that modulate DNA-binding properties. We report in the present paper that the lysine-rich C-terminal extension of M. smegmatis Ku contacts the core protein domain as evidenced by an increase in DNA-binding affinity and a decrease in thermal stability and intrinsic tryptophan fluorescence upon its deletion. Ku deleted for this C-terminus requires free DNA ends for binding, but translocates to internal DNA sites. In contrast, full-length Ku can directly bind DNA without free ends, suggesting that this property is conferred by its C-terminus. Such binding to internal DNA sites may facilitate recruitment to sites of DNA damage. The results of the present study also suggest that extensions beyond the shared core domain may have independently evolved to expand Ku function.

  2. Gode råd til KU om bæredygtig omstilling

    DEFF Research Database (Denmark)

    Lund, Jens Friis

    2016-01-01

    I gennemsnit flyver alle KU-ansatte retur til Cairo årligt. KU's stigende internationalisering skader klimaet, og det kræver bæredygtig omstilling.......I gennemsnit flyver alle KU-ansatte retur til Cairo årligt. KU's stigende internationalisering skader klimaet, og det kræver bæredygtig omstilling....

  3. GPM, DPR Level 2A Ku Precipitation V03

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2AKu algorithm provides precipitation estimates from the Ku radar of the Dual-Frequency Precipitation Radar on the core GPM spacecraft. The product contains one...

  4. Renewal of KU-FEL Facility

    CERN Document Server

    Kii, Toshiteru; Masuda, Kai; Murakami, Shio; Ohgaki, Hideaki; Yamazaki, Tetsuo; Yoshikawa, Kiyoshi; Zen, Heishun

    2004-01-01

    Users demands to a high power tunable IR laser are increasing in Japan in energy-related science, such as basic study of high-efficiency solar cells, generation of new energy source of alcohol and/or H2 from polluted gas, and separation of DNA and/or RNA. To satisfy these demands, we decided to renew our FEL facility more user friendly and to operate more flexibly. Construction and fundamental studies on the KU-FEL have been carried out at a building of Institute of Chemical Research where few other accelerators are operating. Therefore, available machine time for our experiments is quite limited. We are now modifying the room by adding concrete walls of 2-m thickness and some space for users will be available. The present FEL system will be moved to the room A photocathode RF-gun system will be nearly added to the system and the present thermionic RF-gun will be used ternatively according to the demands of users. The photocathode material will be Cs2Te. The room with the shielding will be completed in June, ...

  5. Discovery and characterization of Ku acetylation in Mycobacterium smegmatis.

    Science.gov (United States)

    Zhou, Ying; Chen, Tao; Zhou, Lin; Fleming, Joy; Deng, Jiaoyu; Wang, Xude; Wang, Liwei; Wang, Yingying; Zhang, Xiaoli; Wei, Wenjing; Bi, Lijun

    2015-03-01

    Lysine acetylation is an important post-translational modification and is known to regulate many eukaryotic cellular processes. Little, however, is known about acetylated proteins in prokaryotes. Here, using immunoblotting, mass spectrometry and mutagenesis studies, we investigate the acetylation dynamics of the DNA repair protein Ku and its relationship with the deacetylase protein Sir2 and the non-homologous end joining (NHEJ) pathway in Mycobacterium smegmatis. We report that acetylation of Ku increases with growth, while NHEJ activity decreases, providing support for the hypothesis that acetylation of Ku may be involved in the DNA damage response in bacteria. Ku has multiple lysine sites. Our results indicate that K29 is an important acetylation site and that deficiency of Sir2 or mutation of K29 affects the quantity of Ku and its acetylation dynamics. Our findings expand knowledge of acetylation targets in prokaryotes and indicate a new direction for further research on bacterial DNA repair mechanisms. © FEMS 2014. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Ku-pa-ro en las tablillas de Cnoso

    Directory of Open Access Journals (Sweden)

    José L. Melena

    1974-12-01

    Full Text Available This paper is intended to be a comprehensive analysis of the evidence of ku-pa-ro in the Knossos Linear B tablets. Its main purpose is to set up the importance of such aromatic plant in the Mycenaean economy at Knossos and to identify what kind of sedge was concealed under the name ku-pa-ro and what part of the plant was used and for what purposes. What it is stressed is the usage of the Cyperus rotundus L. (i. e. the ku-pa-ro in the industry of perfumes and as a food additive as well. What is inferred from the discussion on the evidence of ku-pa-ro issues a series of valuable data concerning the localization of certain place-names in the map of Crete, and concerning the explanation of ideogram *171. The high qualities of ku-pa-ro preserved in the tablets lead the author to assume that such a plant was cultivated in Crete and was one of the main aromatic plants used by the Mycenaeans in the making of perfumes.

  7. Expression of Ku correlates with radiation sensitivities in the head and neck cancer cell lines

    International Nuclear Information System (INIS)

    Lee, Sang Wook; Yu, Eun Sil; Yi, So Lyoung; Son, Se Hee; Kim, Jong Hoon; Ahn, Seung Do; Shin, Seong Soo; Choi, Eun Kyung

    2004-01-01

    DNA-dependent protein kinase (DNA-PK) is a serine/threonine kinase consisting of a 470 kDa catalytic subunit (DNA-PKcs) and a heterodimeric regulatory complex, called Ku, which is composed of 70 kDa (Ku 70) and 86 kDa (Ku 80) proteins. The DNA-PK has been shown to play a pivotal role in rejoining DNA double-strand-breaks (dsb) in mammalian cells. The purpose of this study is to examine the relationship between the level of Ku expression and radiation sensitivity. Nine head and neck, cancer cell lines showed various intrinsic radiation sensitivities. Among the nine, AMC-HN-3 cell was the most sensitive for X-ray irradiation and AMC-HN-9 cell was the most resistance. The most sensitive and resistant cell lines were selected and the test sensitivity of radiation and expression of Ku were measured. Radiation sensitivity was obtained by colony forming assay and Ku protein expression using Western blot analysis. Ku80 increased expression by radiation, wheras Ku70 did not. Overexpression of Ku80 protein increased radiation resistance in AMC-HN9 cell line. There was a correlation between Ku80 expression and radiation resistance. Ku80 was shown to play an important role in radiation damage response. Induction of Ku80 expression had an important role in DNA damage repair by radiation. Ku80 expression may be an effective predictive assay of radiosensitivity on head and neck cancer

  8. Regulation of homologous recombination repair protein Rad51 by Ku70

    International Nuclear Information System (INIS)

    Du Liqing; Liu Qiang; Wang Yan; Xu Chang; Cao Jia; Fu Yue; Chen Fenghua; Fan Feiyue

    2013-01-01

    Objective: To explore the regulative effect of non-homologous end joining (NHEJ)protein Ku70 on homologous recombination repair protein Rad51, and to investigate the synergistic mechanism of homologous recombination repair in combination with NHEJ. Methods: Observed Rad51 protein expression after transfect Ku70 small interfering RNA or Ku70 plasmid DNA into tumor cells using Western blot. Results: Expression of Rad51 was obviously reduced after pretreated with Ku70 small interfering RNA. And with the increasing expression of Ku70 protein after transfection of Ku70 plasmid DNA PGCsi3.0-hKu70 into tumor cell lines, the Rad51 protein expression was increased. Conclusion: Ku70 protein has regulating effect on gene expression of Rad51, and it might participate in the collaboration between homologous recombination repair and NHEJ. (authors)

  9. Interspecific variation of intracellular localization and postirradiation movement of Ku70-protein in fibroblastic cells

    International Nuclear Information System (INIS)

    Endoh, Daiji; Hayashi, Masanobu; Okui, Toyo; Kawase, Shiro; Kon, Yasushiro

    2003-01-01

    Ku (Ku70 and Ku80) Proteins are known as components of DNA-dependent protein kinase (DNA-PK) and play an important role for DNA repair. We previously reported that more than 70% of Ku proteins were located in cytoplasm of rat cells, the Ku proteins moved into nuclei of normal rat cells after X-irradiation, Ku proteins also moved into nuclei after X-irradiation but were not retained in nucleus of radiosensitive LEC rat cells. While reports have been shown about mechanisms on nuclear localization of Ku proteins, how Ku proteins export from nucleus is poorly understood. Here we show that C-terminal region of Ku70 protein is important for its cytoplasmic localization. When transfected into LEC rat cells, exogenous intact Ku70 (1-609) tagged with enhanced green fluorescent protein (EGFP-Ku70) localized mainly in the cytoplasm, whereas C-terminal-deletion mutant of Ku70 (1-593) tagged with EGFP (EGFP-Ku70D) was mainly localized in the nucleus. After X-irradiation, the endogenous intact EGFP-Ku70 once moved into nucleus, but returned into the cytoplasm. On the other hand, EGFP-Ku70D was retained in nucleus for two hours after X-irradiation. These results suggest that C-terminal region of Ku70 is included in the postirradiation nuclear export. Next, we investigated the intracellular localization of Ku70 proteins and the movement after X-irradiation of fibroblastic cells prepared from some mammalian species. Ku70 proteins were localized in nucleus and the postirradiation-extranuclear transport was not observed in human and African green monkey cells. On the other hand, Ku70 proteins were mainly localized in cytoplasm and moved into nucleus in mouse, Chinese hamster, Golden hamster, cotton rat, squirrel, cat and dog cells. These results may show that alternatively Ku70 protein is localized in the cytoplasm or nucleus depends on species and translocation of cytoplasmic Ku70 into nucleus is a response against low dose irradiation in fibroblasts of rodents, cats and dogs

  10. SU-E-T-09: A Clinical Implementation and Optimized Dosimetry Study of Freiberg Flap Skin Surface Treatment in High Dose Rate Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Syh, J; Syh, J; Patel, B; Wu, H; Durci, M [Willis-Knighton Medical Center, Shreveport, LA (United States)

    2015-06-15

    Purpose: This case study was designated to confirm the optimized plan was used to treat skin surface of left leg in three stages. 1. To evaluate dose distribution and plan quality by alternating of the source loading catheters pattern in flexible Freiberg Flap skin surface (FFSS) applicator. 2. To investigate any impact on Dose Volume Histogram (DVH) of large superficial surface target volume coverage. 3. To compare the dose distribution if it was treated with electron beam. Methods: The Freiburg Flap is a flexible mesh style surface mold for skin radiation or intraoperative surface treatments. The Freiburg Flap consists of multiple spheres that are attached to each other, holding and guiding up to 18 treatment catheters. The Freiburg Flap also ensures a constant distance of 5mm from the treatment catheter to the surface. Three treatment trials with individual planning optimization were employed: 18 channels, 9 channels of FF and 6 MeV electron beam. The comparisons were highlighted in target coverage, dose conformity and dose sparing of surrounding tissues. Results: The first 18 channels brachytherapy plan was generated with 18 catheters inside the skin-wrapped up flap (Figure 1A). A second 9 catheters plan was generated associated with the same calculation points which were assigned to match prescription for target coverage as 18 catheters plan (Figure 1B). The optimized inverse plan was employed to reduce the dose to adjacent structures such as tibia or fibula. The comparison of DVH’s was depicted on Figure 2. External beam of electron RT plan was depicted in Figure 3. Overcall comparisons among these three were illustrated in Conclusion: The 9-channel Freiburg flap flexible skin applicator offers a reasonably acceptable plan without compromising the coverage. Electron beam was discouraged to use to treat curved skin surface because of low target coverage and high dose in adjacent tissues.

  11. Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis

    International Nuclear Information System (INIS)

    Ma, Jiali; Hui, Pingping; Meng, Wenying; Wang, Na; Xiang, Shihao

    2017-01-01

    The current study focused on the role of Ku70, a DNA-dependent protein kinase (DNA-PK) complex protein, in pancreatic cancer cell resistance to gemcitabine. In both established cell lines (Mia-PaCa-2 and PANC-1) and primary human pancreatic cancer cells, shRNA/siRNA-mediated knockdown of Ku70 significantly sensitized gemcitabine-induced cell death and proliferation inhibition. Meanwhile, gemcitabine-induced DNA damage and subsequent pancreatic cancer cell apoptosis were also potentiated with Ku70 knockdown. On the other hand, exogenous overexpression of Ku70 in Mia-PaCa-2 cells suppressed gemcitabine-induced DNA damage and subsequent cell apoptosis. In a severe combined immune deficient (SCID) mice Mia-PaCa-2 xenograft model, gemcitabine-induced anti-tumor activity was remarkably pontificated when combined with Ku70 shRNA knockdown in the xenografts. The results of this preclinical study imply that Ku70 might be a primary resistance factor of gemcitabine, and Ku70 silence could significantly chemo-sensitize gemcitabine in pancreatic cancer cells. - Highlights: • Ku70 knockdown sensitizes gemcitabine-induced killing of pancreatic cancer cells. • Ku70 knockdown facilitates gemcitabine-induced DNA damage and cell apoptosis. • Ku70 overexpression deceases gemcitabine's sensitivity in pancreatic cancer cells. • Ku70 knockdown sensitizes gemcitabine-induced anti-tumor activity in vivo.

  12. Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis.

    Directory of Open Access Journals (Sweden)

    Huafei Zou

    Full Text Available Caveolin-1, the structural protein component of caveolae, acts as a scaffolding protein that functionally regulates signaling molecules. We show that knockdown of caveolin-1 protein expression enhances chemotherapeutic drug-induced apoptosis and inhibits long-term survival of colon cancer cells. In vitro studies demonstrate that caveolin-1 is a novel Ku70-binding protein, as shown by the binding of the scaffolding domain of caveolin-1 (amino acids 82-101 to the caveolin-binding domain (CBD of Ku70 (amino acids 471-478. Cell culture data show that caveolin-1 binds Ku70 after treatment with chemotherapeutic drugs. Mechanistically, we found that binding of caveolin-1 to Ku70 inhibits the chemotherapeutic drug-induced release of Bax from Ku70, activation of Bax, translocation of Bax to mitochondria and apoptosis. Potentiation of apoptosis by knockdown of caveolin-1 protein expression is greatly reduced in the absence of Bax expression. Finally, we found that overexpression of wild type Ku70, but not a mutant form of Ku70 that cannot bind to caveolin-1 (Ku70 Φ→A, limits the chemotherapeutic drug-induced Ku70/Bax dissociation and apoptosis. Thus, caveolin-1 acts as an anti-apoptotic protein in colon cancer cells by binding to Ku70 and inhibiting Bax-dependent cell death.

  13. Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

    Directory of Open Access Journals (Sweden)

    Christopher R Lopez

    2011-08-01

    Full Text Available The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although Ku avidly binds DNA ends via a preformed channel, its ability to associate with telomeres via this mechanism could be challenged by factors known to bind directly to the chromosome terminus. This has led to uncertainty as to whether Ku itself binds directly to telomeric ends and whether end association is crucial for Ku's telomeric functions. To address these questions, we constructed DNA end binding-defective Ku heterodimers by altering amino acid residues in Ku70 and Ku80 that were predicted to contact DNA. These mutants continued to associate with their known telomere-related partners, such as Sir4, a factor required for telomeric silencing, and TLC1, the RNA component of telomerase. Despite these interactions, we found that the Ku mutants had markedly reduced association with telomeric chromatin and null-like deficiencies for telomere end protection, length regulation, and silencing functions. In contrast to Ku null strains, the DNA end binding defective Ku mutants resulted in increased, rather than markedly decreased, imprecise end-joining proficiency at an induced double-strand break. This result further supports that it was the specific loss of Ku's telomere end binding that resulted in telomeric defects rather than global loss of Ku's functions. The extensive telomere defects observed in these mutants lead us to propose that Ku is an integral component of the terminal telomeric cap, where it promotes a specific architecture that is central to telomere function and maintenance.

  14. Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

    Science.gov (United States)

    Lopez, Christopher R; Ribes-Zamora, Albert; Indiviglio, Sandra M; Williams, Christopher L; Haricharan, Svasti; Bertuch, Alison A

    2011-08-01

    The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although Ku avidly binds DNA ends via a preformed channel, its ability to associate with telomeres via this mechanism could be challenged by factors known to bind directly to the chromosome terminus. This has led to uncertainty as to whether Ku itself binds directly to telomeric ends and whether end association is crucial for Ku's telomeric functions. To address these questions, we constructed DNA end binding-defective Ku heterodimers by altering amino acid residues in Ku70 and Ku80 that were predicted to contact DNA. These mutants continued to associate with their known telomere-related partners, such as Sir4, a factor required for telomeric silencing, and TLC1, the RNA component of telomerase. Despite these interactions, we found that the Ku mutants had markedly reduced association with telomeric chromatin and null-like deficiencies for telomere end protection, length regulation, and silencing functions. In contrast to Ku null strains, the DNA end binding defective Ku mutants resulted in increased, rather than markedly decreased, imprecise end-joining proficiency at an induced double-strand break. This result further supports that it was the specific loss of Ku's telomere end binding that resulted in telomeric defects rather than global loss of Ku's functions. The extensive telomere defects observed in these mutants lead us to propose that Ku is an integral component of the terminal telomeric cap, where it promotes a specific architecture that is central to telomere function and maintenance.

  15. Design of a Ku band miniature multiple beam klystron

    Energy Technology Data Exchange (ETDEWEB)

    Bandyopadhyay, Ayan Kumar, E-mail: ayan.bandyopadhyay@gmail.com; Pal, Debasish; Kant, Deepender [Microwave Tubes Division, CSIR-CEERI, Pilani, Rajasthan-333031 (India); Saini, Anil; Saha, Sukalyan; Joshi, Lalit Mohan

    2016-03-09

    The design of a miniature multiple beam klystron (MBK) working in the Ku-band frequency range is presented in this article. Starting from the main design parameters, design of the electron gun, the input and output couplers and radio frequency section (RF-section) are presented. The design methodology using state of the art commercial electromagnetic design tools, analytical formulae as well as noncommercial design tools are briefly presented in this article.

  16. 'SON-GO-KU' : a dream of automated library

    Science.gov (United States)

    Sato, Mamoru; Kishimoto, Juji

    In the process of automating libraries, the retrieval of books through the browsing of shelves is being overlooked. The telematic library is a document based DBMS which can deliver the content of books by simulating the browsing process. The retrieval actually simulates the process a person would use in selecting a book in a real library, where a visual presentation using a graphic display is substituted. The characteristics of prototype system "Son-Go-Ku" for such retrieval implemented in 1988 are mentioned.

  17. Ku recruits XLF to DNA double-strand breaks.

    Science.gov (United States)

    Yano, Ken-ichi; Morotomi-Yano, Keiko; Wang, Shih-Ya; Uematsu, Naoya; Lee, Kyung-Jong; Asaithamby, Aroumougame; Weterings, Eric; Chen, David J

    2008-01-01

    XRCC4-like factor (XLF)--also known as Cernunnos--has recently been shown to be involved in non-homologous end-joining (NHEJ), which is the main pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. XLF is likely to enhance NHEJ by stimulating XRCC4-ligase IV-mediated joining of DSBs. Here, we report mechanistic details of XLF recruitment to DSBs. Live cell imaging combined with laser micro-irradiation showed that XLF is an early responder to DSBs and that Ku is essential for XLF recruitment to DSBs. Biochemical analysis showed that Ku-XLF interaction occurs on DNA and that Ku stimulates XLF binding to DNA. Unexpectedly, XRCC4 is dispensable for XLF recruitment to DSBs, although photobleaching analysis showed that XRCC4 stabilizes the binding of XLF to DSBs. Our observations showed the direct involvement of XLF in the dynamic assembly of the NHEJ machinery and provide mechanistic insights into DSB recognition.

  18. Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate.

    Science.gov (United States)

    Castore, Reneau; Hughes, Cameron; Debeaux, Austin; Sun, Jingxin; Zeng, Cailing; Wang, Shih-Ya; Tatchell, Kelly; Shi, Runhua; Lee, Kyung-Jong; Chen, David J; Harrison, Lynn

    2011-11-01

    Radiotherapy and chemotherapy are effective cancer treatments due to their ability to generate DNA damage. The major lethal lesion is the DNA double-strand break (DSB). Human cells predominantly repair DSBs by non-homologous end joining (NHEJ), which requires Ku70, Ku80, DNA-PKcs, DNA ligase IV and accessory proteins. Repair is initiated by the binding of the Ku heterodimer at the ends of the DSB and this recruits DNA-PKcs, which initiates damage signaling and functions in repair. NHEJ also exists in certain types of bacteria that have dormant phases in their life cycle. The Mycobacterium tuberculosis Ku (Mt-Ku) resembles the DNA-binding domain of human Ku but does not have the N- and C-terminal domains of Ku70/80 that have been implicated in binding mammalian NHEJ repair proteins. The aim of this work was to determine whether Mt-Ku could be used as a tool to bind DSBs in mammalian cells and sensitize cells to DNA damage. We generated a fusion protein (KuEnls) of Mt-Ku, EGFP and a nuclear localization signal that is able to perform bacterial NHEJ and hence bind DSBs. Using transient transfection, we demonstrated that KuEnls is able to bind laser damage in the nucleus of Ku80-deficient cells within 10 sec and remains bound for up to 2 h. The Mt-Ku fusion protein was over-expressed in U2OS cells and this increased the sensitivity of the cells to bleomycin sulfate. Hydrogen peroxide and UV radiation do not predominantly produce DSBs and there was little or no change in sensitivity to these agents. Since in vitro studies were unable to detect binding of Mt-Ku to DNA-PKcs or human Ku70/80, this work suggests that KuEnls sensitizes cells by binding DSBs, preventing human NHEJ. This study indicates that blocking or decreasing the binding of human Ku to DSBs could be a method for enhancing existing cancer treatments.

  19. Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.

    Directory of Open Access Journals (Sweden)

    Chengwan Zhang

    Full Text Available UTX is known as a general factor that activates gene transcription during development. Here, we demonstrate an additional essential role of UTX in the DNA damage response, in which it upregulates the expression of ku80 in Drosophila, both in cultured cells and in third instar larvae. We further showed that UTX mediates the expression of ku80 by the demethylation of H3K27me3 at the ku80 promoter upon exposure to ionizing radiation (IR in a p53-dependent manner. UTX interacts physically with p53, and both UTX and p53 are recruited to the ku80 promoter following IR exposure in an interdependent manner. In contrast, the loss of utx has little impact on the expression of ku70, mre11, hid and reaper, suggesting the specific regulation of ku80 expression by UTX. Thus, our findings further elucidate the molecular function of UTX.

  20. Preclinical evaluation of (111)In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancer.

    Science.gov (United States)

    Evans-Axelsson, Susan; Vilhelmsson Timmermand, Oskar; Welinder, Charlotte; Borrebaeck, Carl Ak; Strand, Sven-Erik; Tran, Thuy A; Jansson, Bo; Bjartell, Anders

    2014-01-01

    The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody was pre-administered at different time-points followed by a single intravenous injection of (111)In-DTPA-INCA-X. At 48, 72 and 96 h post-injection, tissues were harvested, and the antibody distribution was determined by measuring radioactivity. Preclinical SPECT/CT imaging of mice with and without the predose was performed at 48 hours post-injection of labeled DTPA-INCA-X. Biodistribution of the labeled antibody showed enriched activity in tumor, spleen and liver. Animals pre-administered with DTPA-INCA-X showed increased tumor uptake and blood content of (111)In-DTPA-INCA-X with reduced splenic and liver uptake. The in vitro and in vivo data presented show that the (111)In-labeled INCA-X antibody is internalized into prostate cancer cells and by pre-administering non-labeled DTPA-INCA-X, we were able to significantly reduce the off target binding and increase the (111)In-DTPA-INCA-X mAb uptake in PC-3, PC-3M-Lu2 and DU145 xenografts. The results are encouraging and identifying the Ku70/Ku80 antigen as a target is worth further investigation for functional imaging of prostate cancer.

  1. Preclinical evaluation of 111In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancer

    Science.gov (United States)

    Evans-Axelsson, Susan; Vilhelmsson Timmermand, Oskar; Welinder, Charlotte; Borrebaeck, Carl AK; Strand, Sven-Erik; Tran, Thuy A; Jansson, Bo; Bjartell, Anders

    2014-01-01

    The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the 111In-labeled human internalizing antibody, INCA-X (111In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody was pre-administered at different time-points followed by a single intravenous injection of 111In-DTPA-INCA-X. At 48, 72 and 96 h post-injection, tissues were harvested, and the antibody distribution was determined by measuring radioactivity. Preclinical SPECT/CT imaging of mice with and without the predose was performed at 48 hours post-injection of labeled DTPA-INCA-X. Biodistribution of the labeled antibody showed enriched activity in tumor, spleen and liver. Animals pre-administered with DTPA-INCA-X showed increased tumor uptake and blood content of 111In-DTPA-INCA-X with reduced splenic and liver uptake. The in vitro and in vivo data presented show that the 111In-labeled INCA-X antibody is internalized into prostate cancer cells and by pre-administering non-labeled DTPA-INCA-X, we were able to significantly reduce the off target binding and increase the 111In-DTPA-INCA-X mAb uptake in PC-3, PC-3M-Lu2 and DU145 xenografts. The results are encouraging and identifying the Ku70/Ku80 antigen as a target is worth further investigation for functional imaging of prostate cancer. PMID:24982817

  2. Bioavailability of heavy metals, germanium and rare earth elements at Davidschacht dump-field in mine affected area of Freiberg (Saxony)

    Science.gov (United States)

    Midula, Pavol; Wiche, Oliver

    2016-04-01

    Bioavailability research presents an essential tool, in modern phytoremediation and phytomining technologies, allowing the estimation of plant available fractions of elements in soils. However, up to date, sufficient interdisciplinary knowledge on the biogeochemically impacted behavior of specific target elements, in particular Ge and REEs in mining affected soils and their uptake into strategically used plants is lacking. This presented work is focused on a correlation study between the concentrations of selected heavy metals, Ge and REEs in soils formed on the top of the dump-field of Davidschacht and the corresponding their concentrations in 12 vascular plant species. The mine-dump of Davidschacht, situated in the Freiberg (Saxony, Germany) municipality area was chosen as the study area, which has been considered to be a high contaminated enclave, due to the mining history of the region. In total 12 sampling sites with differing composition of plant species were selected. At each sampling site soil samples from a soil depth of 0 - 10 cm and samples of plant material (shoots) were taken. The soil samples were analysed for total concentration of elements, pH (H2O) and consequently analysed by 4-step sequential extraction (SE) to determine fractions of elements that are mobile (fraction 1), acid soluble (pH 5) (fraction 2), bound to organic and oxidizable matter (fraction 3) and bound to amorphic oxides (fraction 4). The plant material was decomposed by hydrofluoric acid in order to extract the elements. Concentrations of elements in soil extracts and digestion solutions were analysed by ICP-MS. For all species bioconcentration factor (BCF) was calculated of the total concentration of elements in order to investigate the bioaccumulation potential. Arsenic (As), cadmium (Cd) and lead (Pb) were chosen as the representative heavy metals. Within the REEs neodymium (Nd) and cerium (Ce) were selected as representatives for all REEs, since Nd and Ce correlated significant

  3. The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends

    DEFF Research Database (Denmark)

    Weterings, Eric; Verkaik, Nicole S; Keijzers, Guido

    2008-01-01

    Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PK(CS)) an......Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA......-PK(CS)) and the XRCC4/ligase IV complex. Activation of the DNA-PK(CS) serine/threonine kinase requires an interaction with Ku70/80 and is essential for NHEJ-mediated DSB repair. In contrast to previous models, we found that the carboxy terminus of Ku80 is not absolutely required for the recruitment and activation...... was phosphorylated to normal levels. This resulted in severely reduced levels of Artemis nuclease activity in vivo and in vitro. We therefore conclude that the Ku80 carboxy terminus is important to support DNA-PK(CS) autophosphorylation at specific sites, which facilitates DNA end processing by the Artemis...

  4. Superconducting magnet for a Ku-band maser.

    Science.gov (United States)

    Berwin, R.; Wiebe, E.; Dachel, P.

    1972-01-01

    A superconducting magnet to provide a uniform magnetic field of up to 8000 G in a 1.14-cm gap for the 15.3-GHz (Ku-band) traveling wave maser is described. The magnet operates in a persistent mode in the vacuum environment of a closed-cycle helium refrigerator (4.5 K). The features of a superconducting switch, which has both leads connected to 4.5 K heat stations and thereby does not receive heat generated by the magnet charging leads, are described.

  5. Airborn Ku-band polarimetric radar remote sensing of terrestrial snow cover

    Science.gov (United States)

    Simon H. Yueh; Steve J. Dinardo; Ahmed Akgiray; Richard West; Donald W. Cline; Kelly Elder

    2009-01-01

    Characteristics of the Ku-band polarimetric scatterometer (POLSCAT) data acquired from five sets of aircraft flights in the winter months of 2006-2008 for the second Cold Land Processes Experiment (CLPX-II) in Colorado are described in this paper. The data showed the response of the Ku-band radar echoes to snowpack changes for various types of background vegetation in...

  6. Klimatizace líhně kuřat

    OpenAIRE

    Petr, Lukáš

    2009-01-01

    Diplomová práce se zabývá návrhem systému klimatizačního zařízení pro prostory s líhněmi kuřat. Práce v úvodu krátce přibližuje problematiku klimatizace, představuje dispozice objektu a nastiňuje požadavky na mikroklima pro správnou inkubaci vajec a líhnutí kuřat. Praktická část diplomové práce se dělí na dva základní úseky, a to výpočtový a návrhový. Výpočtová část se zabývá stanovením množství přiváděného čerstvého klimatizačního vzduchu, výpočtem tepelných ztrát, tepelné zátěže a psychrome...

  7. Ku70, Ku80, and sClusterin: A Cluster of Predicting Factors for Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer

    International Nuclear Information System (INIS)

    Pucci, Sabina; Polidoro, Chiara; Joubert, Alessandro; Mastrangeli, Francesca; Tolu, Barbara; Benassi, Michaela; Fiaschetti, Valeria; Greco, Laura; Miceli, Roberto; Floris, Roberto; Novelli, Giuseppe; Orlandi, Augusto; Santoni, Riccardo

    2017-01-01

    Purpose: The identification of predictive biomarkers for neoadjuvant chemoradiation therapy (CRT) is a current clinical need. The heterodimer Ku70/80 plays a critical role in DNA repair and cell death induction after damage. The aberrant expression and localization of these proteins fail to control DNA repair and apoptosis. sClusterin is the Ku70 partner that sterically inhibits Bax-dependent cell death after damage in some pathologic conditions. This study sought to evaluate the molecular relevance of Ku70-Ku80-Clu as a molecular cluster predicting the response to neoadjuvant CRT in patients with locally advanced rectal cancer (LARC). Methods and Materials: Patients enrolled in this study underwent preoperative CRT followed by surgical excision. A retrospective study based on individual response, evaluated by computed tomography and diffusion-weighted magnetic resonance imaging, identified responder (56%) and no-responder patients (44%). Ku70/80 and Clu expression were observed in biopsy specimens obtained before and after treatment with neoadjuvant CRT from the same LARC patients. In vitro studies before and after irradiation were also performed on radioresistant (SW480) and radiosensitive (SW620) colorectal cancer cell lines, mimicking sensitive or resistant tumor behavior. Results: We found a conventional nuclear localization of Ku70/80 in pretherapeutic tumor biopsies of responder patients, in agreement with their role in DNA repair and regulating apoptosis. By contrast, in the no-responder population we observed an unconventional overexpression of Ku70 in the cytoplasm (P<.001). In this context we also overexpression of sClu in the cytoplasm, which accorded with its role in stabilizing of Bax-Ku70 complex, inhibiting Bax-dependent apoptosis. Strikingly, Ku80 in these tumor tissues was lost (P<.005). In vitro testing of colon cancer cells finally confirmed the results observed in tumor biopsy specimens, proving that Ku70/80-Clu deregulation is extensively

  8. Ku70, Ku80, and sClusterin: A Cluster of Predicting Factors for Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pucci, Sabina, E-mail: sabina.pucci@uniroma2.it; Polidoro, Chiara; Joubert, Alessandro; Mastrangeli, Francesca; Tolu, Barbara; Benassi, Michaela; Fiaschetti, Valeria; Greco, Laura; Miceli, Roberto; Floris, Roberto; Novelli, Giuseppe; Orlandi, Augusto; Santoni, Riccardo

    2017-02-01

    Purpose: The identification of predictive biomarkers for neoadjuvant chemoradiation therapy (CRT) is a current clinical need. The heterodimer Ku70/80 plays a critical role in DNA repair and cell death induction after damage. The aberrant expression and localization of these proteins fail to control DNA repair and apoptosis. sClusterin is the Ku70 partner that sterically inhibits Bax-dependent cell death after damage in some pathologic conditions. This study sought to evaluate the molecular relevance of Ku70-Ku80-Clu as a molecular cluster predicting the response to neoadjuvant CRT in patients with locally advanced rectal cancer (LARC). Methods and Materials: Patients enrolled in this study underwent preoperative CRT followed by surgical excision. A retrospective study based on individual response, evaluated by computed tomography and diffusion-weighted magnetic resonance imaging, identified responder (56%) and no-responder patients (44%). Ku70/80 and Clu expression were observed in biopsy specimens obtained before and after treatment with neoadjuvant CRT from the same LARC patients. In vitro studies before and after irradiation were also performed on radioresistant (SW480) and radiosensitive (SW620) colorectal cancer cell lines, mimicking sensitive or resistant tumor behavior. Results: We found a conventional nuclear localization of Ku70/80 in pretherapeutic tumor biopsies of responder patients, in agreement with their role in DNA repair and regulating apoptosis. By contrast, in the no-responder population we observed an unconventional overexpression of Ku70 in the cytoplasm (P<.001). In this context we also overexpression of sClu in the cytoplasm, which accorded with its role in stabilizing of Bax-Ku70 complex, inhibiting Bax-dependent apoptosis. Strikingly, Ku80 in these tumor tissues was lost (P<.005). In vitro testing of colon cancer cells finally confirmed the results observed in tumor biopsy specimens, proving that Ku70/80-Clu deregulation is extensively

  9. Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients

    Directory of Open Access Journals (Sweden)

    Lu YF

    2014-10-01

    Full Text Available Yuanfang Lu,1,2 Jingyan Gao,1,3 Yuanming Lu,1 1Department of Toxicology, School of Public Health, Guilin Medical University, Guangxi, People's Republic of China; 2Department of Clinical Research Center, Affiliated 2nd Hospital of Nanjing Medical University, Nanjing, People's Republic of China; 3Department of Human Anatomy and Histo-Embryology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China Background: Double-strand DNA breaks (DSBs are a key factor in carcinogenesis. The necessary repair of DSBs is pivotal in maintaining normal cell division. To address the relationship between altered expression of DSB repair of proteins Ku70 and ataxia-telangiectasia mutated (ATM in colorectal cancer (CRC, we examined the expression levels and patterns of Ku70 and ATM in CRC samples. Methods: Expression and coexpression of Ku70 and ATM were investigated by using real-time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in CRC and pericancerous samples from 112 Chinese patients. Results: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate. Conclusion: Downregulated Ku70 and ATM were associated with poor disease-free survival. Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC. Keywords: DNA double-strand breaks, ataxia-telangiectasia mutated, Ku70, colorectal cancer

  10. The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends.

    Science.gov (United States)

    Weterings, Eric; Verkaik, Nicole S; Keijzers, Guido; Florea, Bogdan I; Wang, Shih-Ya; Ortega, Laura G; Uematsu, Naoya; Chen, David J; van Gent, Dik C

    2009-03-01

    Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PK(CS)) and the XRCC4/ligase IV complex. Activation of the DNA-PK(CS) serine/threonine kinase requires an interaction with Ku70/80 and is essential for NHEJ-mediated DSB repair. In contrast to previous models, we found that the carboxy terminus of Ku80 is not absolutely required for the recruitment and activation of DNA-PK(CS) at DSBs, although cells that harbored a carboxy-terminal deletion in the Ku80 gene were sensitive to ionizing radiation and showed reduced end-joining capacity. More detailed analysis of this repair defect showed that DNA-PK(CS) autophosphorylation at Thr2647 was diminished, while Ser2056 was phosphorylated to normal levels. This resulted in severely reduced levels of Artemis nuclease activity in vivo and in vitro. We therefore conclude that the Ku80 carboxy terminus is important to support DNA-PK(CS) autophosphorylation at specific sites, which facilitates DNA end processing by the Artemis endonuclease and the subsequent joining reaction.

  11. The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends▿

    Science.gov (United States)

    Weterings, Eric; Verkaik, Nicole S.; Keijzers, Guido; Florea, Bogdan I.; Wang, Shih-Ya; Ortega, Laura G.; Uematsu, Naoya; Chen, David J.; van Gent, Dik C.

    2009-01-01

    Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PKCS) and the XRCC4/ligase IV complex. Activation of the DNA-PKCS serine/threonine kinase requires an interaction with Ku70/80 and is essential for NHEJ-mediated DSB repair. In contrast to previous models, we found that the carboxy terminus of Ku80 is not absolutely required for the recruitment and activation of DNA-PKCS at DSBs, although cells that harbored a carboxy-terminal deletion in the Ku80 gene were sensitive to ionizing radiation and showed reduced end-joining capacity. More detailed analysis of this repair defect showed that DNA-PKCS autophosphorylation at Thr2647 was diminished, while Ser2056 was phosphorylated to normal levels. This resulted in severely reduced levels of Artemis nuclease activity in vivo and in vitro. We therefore conclude that the Ku80 carboxy terminus is important to support DNA-PKCS autophosphorylation at specific sites, which facilitates DNA end processing by the Artemis endonuclease and the subsequent joining reaction. PMID:19103741

  12. Initial assessment of an airborne Ku-band polarimetric SAR.

    Energy Technology Data Exchange (ETDEWEB)

    Raynal, Ann Marie; Doerry, Armin Walter

    2013-02-01

    Polarimetric synthetic aperture radar (SAR) has been used for a variety of dual-use research applications since the 1940s. By measuring the direction of the electric field vector from radar echoes, polarimetry may enhance an analysts understanding of scattering effects for both earth monitoring and tactical surveillance missions. Polarimetry may provide insight into surface types, materials, or orientations for natural and man-made targets. Polarimetric measurements may also be used to enhance the contrast between scattering surfaces such as man-made objects and their surroundings. This report represents an initial assessment of the utility of, and applications for, polarimetric SAR at Ku-band for airborne or unmanned aerial systems.

  13. Shuttle orbiter Ku-band radar/communications system design evaluation. Deliverable test equipment evaluation

    Science.gov (United States)

    Maronde, R. G.

    1980-07-01

    The Ku-band test equipment, known as the Deliverable System Test equipment (DSTE), is reviewed and evaluated. The DSTE is semiautomated and computer programs were generated for 14 communication mode tests and 17 radar mode tests. The 31 test modules provide a good cross section of tests with which to exercise the Ku-band system; however, it is very limited when being used to verify Ku-band system performance. More detailed test descriptions are needed, and a major area of concern is the DSTE sell-off procedure which is inadequate.

  14. Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

    International Nuclear Information System (INIS)

    Lara, Pedro Carlos; Lloret, Marta; Clavo, Bernardino; Apolinario, Rosa Maria; Bordon, Elisa; Rey, Agustin; Falcon, Orlando; Alonso, Ana Ruiz; Belka, Claus

    2008-01-01

    Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma

  15. Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression

    International Nuclear Information System (INIS)

    Ohno, Masae; Kunimoto, Masaaki; Nishizuka, Makoto; Osada, Shigehiro; Imagawa, Masayoshi

    2009-01-01

    The farnesoid X receptor (FXR; NR1H4) is a member of the nuclear receptor superfamily and regulates the expression of genes involved in enterohepatic circulation and the metabolism of bile acids. Based on functional analyses, nuclear receptors are divided into regions A-F. To explore the cofactors interacting with FXR, we performed a pull-down assay using GST-fused to the N-terminal A/B region and the C region, which are required for the ligand-independent transactivation and DNA-binding, respectively, of FXR, and nuclear extracts from HeLa cells. We identified DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Ku80, and Ku70 as FXR associated factors. These proteins are known to have an important role in DNA repair, recombination, and transcription. DNA-PKcs mainly interacted with the A/B region of FXR, whereas the Ku proteins interacted with the C region and with the D region (hinge region). Chromatin immunoprecipitation assays revealed that the Ku proteins associated with FXR on the bile salt export pump (BSEP) promoter. Furthermore, we demonstrated that ectopic expression of the Ku proteins decreased the promoter activity and expression of BSEP gene mediated by FXR. These results suggest that the Ku proteins function as corepressors for FXR.

  16. Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

    Directory of Open Access Journals (Sweden)

    Yong Jun Choi

    Full Text Available Ku70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS to repair DNA double strand breaks (DSBs through the nonhomologous end joining (NHEJ pathway. As expected mutating these genes in mice caused a similar DSB repair-defective phenotype. However, ku70(-/- cells and ku80(-/- cells also appeared to have a defect in base excision repair (BER. BER corrects base lesions, apurinic/apyrimidinic (AP sites and single stand breaks (SSBs utilizing a variety of proteins including glycosylases, AP endonuclease 1 (APE1 and DNA Polymerase β (Pol β. In addition, deleting Ku70 was not equivalent to deleting Ku80 in cells and mice. Therefore, we hypothesized that free Ku70 (not bound to Ku80 and/or free Ku80 (not bound to Ku70 possessed activity that influenced BER. To further test this hypothesis we performed two general sets of experiments. The first set showed that deleting either Ku70 or Ku80 caused an NHEJ-independent defect. We found ku80(-/- mice had a shorter life span than dna-pkcs(-/- mice demonstrating a phenotype that was greater than deleting the holoenzyme. We also found Ku70-deletion induced a p53 response that reduced the level of small mutations in the brain suggesting defective BER. We further confirmed that Ku80-deletion impaired BER via a mechanism that was not epistatic to Pol β. The second set of experiments showed that free Ku70 and free Ku80 could influence BER. We observed that deletion of either Ku70 or Ku80, but not both, increased sensitivity of cells to CRT0044876 (CRT, an agent that interferes with APE1. In addition, free Ku70 and free Ku80 bound to AP sites and in the case of Ku70 inhibited APE1 activity. These observations support a novel role for free Ku70 and free Ku80 in altering BER.

  17. RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX

    DEFF Research Database (Denmark)

    Shamanna, Raghavendra A; Singh, Dharmendra Kumar; Lu, Huiming

    2014-01-01

    -irradiation and resulted in accumulation of 53BP1 foci after irradiation, indicating defects in the processing of DSB. We find that RECQL4 interacts with the Ku70/Ku80 heterodimer, part of the DNA-dependent protein kinase (DNA-PK) complex, via its N-terminal domain. Further, RECQL4 stimulates higher order DNA binding...... of Ku70/Ku80 to a blunt end DNA substrate. Taken together, these results implicate that RECQL4 participates in the NHEJ pathway of DSB repair via a functional interaction with the Ku70/Ku80 complex. This is the first study to provide both in vitro and in vivo evidence for a role of a RecQ helicase...

  18. Analysis of Fade Dynamic at Ku-Band in Malaysia

    Directory of Open Access Journals (Sweden)

    Siat Ling Jong

    2014-01-01

    Full Text Available This work investigates fade dynamics of satellite communication systems in equatorial heavy rain region based on a one year of Ku-band propagation measurement campaign carried out in Universiti Teknologi Malaysia (UTM, Johor, Malaysia. First order statistics of rain attenuation are deduced and the results are found to be in good agreement with those obtained from other beacon measurements gathered within the same area (Kuala Lumpur. Moreover, the fade duration and slope statistics of the satellite signal variations are also carefully derived and subsequently compared with the ITU-R recommendation model. Such information is useful for the system operator and radio communication engineer for the design of appropriate fade mitigation techniques as well as the quality of service that could be offered to the user (according to the time interval for a typical day. Further evaluation on the performances of several ITU-R models in the heavy rain region are needed based on the measurement database available of this climatic region.

  19. Somatic mutation frequency in the stamen hairs of Tradescantia KU 7 and KU 9 clones exposed to low-level gamma rays

    International Nuclear Information System (INIS)

    Ichikawa, S.; Nagashima, C.; Takahashi, C.S.

    1981-01-01

    Two triploid clones (KU 7 and KU 9) of Tradescantia heterozygous for flower color were exposed to 1 to 42.3R of gamma rays or the scattering radiation in the gamma field of the Institute of Radiation . Breeding. Occurrence of somatic pink mutations in the stamen hairs was investigated 10 to 16 (or 14) days after irradiation. The mutation frequency was found to increase linearly with increasing gamma-ray exposure in the both clones, and the frequencies of 0.437 and 0.468 pink mutant events per 10 3 hairs per R were determined for KU 7 and KU 9, respectively. When the data collected in the present study were analyzed together with those obtained in earlier experiments in the gamma field, linear relationships of the somatic mutation frequency with gamma-ray (2.1 to 201.6R) and scattering radiation (0.72 to 57.6R) exposures were confirmed. Scattering radiation was found to have a genetical efficiency more than two times higher than that of gamma rays. Variation of spontaneous mutation frequency observed in the present study and in earlier studies was inversely correlated to temperature variation

  20. A novel small molecule inhibitor of the DNA repair protein Ku70/80.

    Science.gov (United States)

    Weterings, Eric; Gallegos, Alfred C; Dominick, Lauren N; Cooke, Laurence S; Bartels, Trace N; Vagner, Josef; Matsunaga, Terry O; Mahadevan, Daruka

    2016-07-01

    Non-Homologous End-Joining (NHEJ) is the predominant pathway for the repair of DNA double strand breaks (DSBs) in human cells. The NHEJ pathway is frequently upregulated in several solid cancers as a compensatory mechanism for a separate DSB repair defect or for innate genomic instability, making this pathway a powerful target for synthetic lethality approaches. In addition, NHEJ reduces the efficacy of cancer treatment modalities which rely on the introduction of DSBs, like radiation therapy or genotoxic chemotherapy. Consequently, inhibition of the NHEJ pathway can modulate a radiation- or chemo-refractory disease presentation. The Ku70/80 heterodimer protein plays a pivotal role in the NHEJ process. It possesses a ring-shaped structure with high affinity for DSBs and serves as the first responder and central scaffold around which the rest of the repair complex is assembled. Because of this central position, the Ku70/80 dimer is a logical target for the disruption of the entire NHEJ pathway. Surprisingly, specific inhibitors of the Ku70/80 heterodimer are currently not available. We here describe an in silico, pocket-based drug discovery methodology utilizing the crystal structure of the Ku70/80 heterodimer. We identified a novel putative small molecule binding pocket and selected several potential inhibitors by computational screening. Subsequent biological screening resulted in the first identification of a compound with confirmed Ku-inhibitory activity in the low micro-molar range, capable of disrupting the binding of Ku70/80 to DNA substrates and impairing Ku-dependent activation of another NHEJ factor, the DNA-PKCS kinase. Importantly, this compound synergistically sensitized human cell lines to radiation treatment, indicating a clear potential to diminish DSB repair. The chemical scaffold we here describe can be utilized as a lead-generating platform for the design and development of a novel class of anti-cancer agents. Copyright © 2016 Elsevier B.V. All

  1. Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice

    International Nuclear Information System (INIS)

    Iwai, Hiroyuki; Matsuno, Etsuko; Sasai, Keisuke; Abe, Mitsuyuki; Shibamoto, Yuta

    1994-01-01

    In a clinical trial in which a 2-nitroimidazole radiosensitizer was administered repeatedly, the dose-limiting toxicity was found to be peripheral neuropathy. In the present study, the in vivo radiosensitizing activity of KU-2285 in combination with radiation dose fractionation, and the pharmacokinetics of cumulative dosing of KU-2285 in the peripheral nerves were examined. The ability of three nitroimidazoles, misonidazole (MISO), etanidazole (SR-2508) and KU-2285, to sensitize SCCVII tumors to radiation treatment has been compared for drug doses in the range 0-200 mg/kg. Single radiation doses or two different fractionation schedules (6 Gy/fractions x three fractions/48 h or 5 Gy/fractions x five fractions/48 h) were used; the tumor cell survival was determined using an in vivo/in vitro colony assay. The pharmacokinetics in the sciatic nerves were undertaken, when KU-2285 or etanidazole were injected at a dose of 200 mg/kg intravenously one, two, three, or four times at 2-h intervals. At less than 100 mg/kg, KU-2285 sensitized SCCVII tumors more than MISO and SR-2508 by fractionated irradiation. Evaluation of pharmacokinetics in the peripheral nerves showed that the apparent biological half-life of SR-2508 increased with the increases in the number of administrations, whereas that of KU-2285 became shorter. Since most clinical radiotherapy is given in small multiple fractions, KU-2285 appears to be a hypoxic cell radiosensitizer that could be useful in such regimens, and that poses no risk of chronic peripheral neurotoxicity. 12 refs., 5 figs., 1 tab

  2. Construction of cell model of silenced Ku80 and the radiobiology change of HeLa cell

    International Nuclear Information System (INIS)

    Zhuang Liang; Yu Shiying; Huang Xiaoyuan; Xiong Huihua; Xiong Hua; Li Xiaolan; Leng Yan

    2007-01-01

    Objective: To construct the cell model of Ku80 with expression inhibited by siRNA and to explore the role of Ku80 in radiobiology. Methods: Ku80-siRNA expression plasmids were constructed and HeLa cells were transfected with these plasmids by lipofectamine. Western blotting was used to measure the expression of Ku80. After irradiation with 6 MV X ray, cells were collected and analyzed by flow cytometry for apoptosis and cell cycle at 24, 48 and 72 h; The radiobiology parameters of four cell lines were acquired by clone formation array. Results: Three stable transfected cell clones were obtained, and the inhibition rates of Ku80 protein expression of two positive clones were 89.3% and 96.4%; The apoptosis rates of HeLa cells Ku80 inhibited were higher than control cells at 48 and 72 after X ray irradiation (P 0.05). HeLa cells of silenced Ku80 had lower SF 2 and D 0 than control cells, and their SER (sensitization enhancement ratio) based on D 10 were 1.315 and 1.365, respectively. Conclusions: The HeLa cell models with Ku80 expression suppressed were successfully established; the inhibition of Ku80 by siRNA could enhance the radiosensitivity of HeLa cells. (authors)

  3. Expression of Ku70 predicts results of radiotherapy in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Tomokazu; Someya, Masanori; Hori, Masakazu; Nakata, Kensei; Kitagawa, Mio; Tsuchiya, Takaaki; Sakata, Koh-ichi [Sapporo Medical University School of medicine, Department of Radiology, Chuo-ku, Sapporo, Hokkaido (Japan); Matsumoto, Yoshihisa [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Meguro-ku, Tokyo (Japan); Nojima, Masanori [The University of Tokyo, The Institute of Medical Science Hospital, Minatoku, Tokyo (Japan); Masumori, Naoya [Sapporo Medical University School of medicine, Department of Urology, Chuo-ku, Sapporo, Hokkaido (Japan); Hasegawa, Tadashi [Sapporo Medical University School of medicine, Department of Surgical Pathology, Chuo-ku, Sapporo, Hokkaido (Japan)

    2017-01-15

    Therapeutic strategy for prostate cancer is decided according to T stage, Gleason score, and prostate-specific antigen (PSA) level. These clinical factors are not accurate enough to predict individual risk of local failure of prostate cancer after radiotherapy. Parameters involved with radiosensitivity are required to improve the predictive capability for local relapse. We analyzed 58 patients with localized adenocarcinoma of the prostate between August 2007 and October 2010 treated with 76 Gy of intensity-modulated radiotherapy (IMRT) as a discovery cohort and 42 patients between March 2001 and May 2007 treated with three-dimensional conformal radiotherapy (3D-CRT) as a validation cohort. Immunohistochemical examination for proteins involved in nonhomologous end-joining was performed using biopsy specimens. Ku70 expression was not correlated with various clinical parameters, such as the Gleason score and D'amico risk classification, indicating that Ku70 expression was an independent prognostic factor. The predictive value for PSA relapse was markedly improved after the combination of Gleason score and Ku70 expression, as compared with Gleason score alone. In patients treated with radiotherapy and androgen deprivation therapy (ADT), no relapses were observed in patients with Gleason score ≤7 or low Ku70 expression. In contrast, patients with Gleason score ≥8 and high Ku70 expression had high PSA relapse rates. In the validation cohort, similar results were obtained. Treatment with 76 Gy and ADT can be effective for patients with Gleason score ≤7 or low Ku70 expression, but is not enough for patients with Gleason score ≥8 and high Ku70 expression and, thus, require other treatment approaches. (orig.) [German] Die Behandlung beim Prostatakarzinom ist abhaengig von T-Stadium, Gleason-Score und prostataspezifischem Antigen (PSA). Diese klinischen Faktoren sind jedoch zu ungenau, um das individuelle Lokalrezidivrisiko beim Prostatakarzinom nach

  4. C-terminal low-complexity sequence repeats of Mycobacterium smegmatis Ku modulate DNA binding.

    Science.gov (United States)

    Kushwaha, Ambuj K; Grove, Anne

    2013-01-24

    Ku protein is an integral component of the NHEJ (non-homologous end-joining) pathway of DSB (double-strand break) repair. Both eukaryotic and prokaryotic Ku homologues have been characterized and shown to bind DNA ends. A unique feature of Mycobacterium smegmatis Ku is its basic C-terminal tail that contains several lysine-rich low-complexity PAKKA repeats that are absent from homologues encoded by obligate parasitic mycobacteria. Such PAKKA repeats are also characteristic of mycobacterial Hlp (histone-like protein) for which they have been shown to confer the ability to appose DNA ends. Unexpectedly, removal of the lysine-rich extension enhances DNA-binding affinity, but an interaction between DNA and the PAKKA repeats is indicated by the observation that only full-length Ku forms multiple complexes with a short stem-loop-containing DNA previously designed to accommodate only one Ku dimer. The C-terminal extension promotes DNA end-joining by T4 DNA ligase, suggesting that the PAKKA repeats also contribute to efficient end-joining. We suggest that low-complexity lysine-rich sequences have evolved repeatedly to modulate the function of unrelated DNA-binding proteins.

  5. The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks.

    Science.gov (United States)

    Balestrini, Alessia; Ristic, Dejan; Dionne, Isabelle; Liu, Xiao Z; Wyman, Claire; Wellinger, Raymund J; Petrini, John H J

    2013-06-27

    Single-ended double-strand breaks (DSBs) are a common form of spontaneous DNA break, generated when the replisome encounters a discontinuity in the DNA template. Given their prevalence, understanding the mechanisms governing the fate(s) of single-ended DSBs is important. We describe the influence of the Ku heterodimer and Mre11 nuclease activity on processing of single-ended DSBs. Separation-of-function alleles of yku70 were derived that phenocopy Ku deficiency with respect to single-ended DSBs but remain proficient for NHEJ. The Ku mutants fail to regulate Exo1 activity, and bypass the requirement for Mre11 nuclease activity in the repair of camptothecin-induced single-ended DSBs. Ku mutants exhibited reduced affinity for DNA ends, manifest as both reduced end engagement and enhanced probability of diffusing inward on linear DNA. This study reveals an interplay between Ku and Mre11 in the metabolism of single-ended DSBs that is distinct from repair pathway choice at double-ended DSBs. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  6. The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks

    Directory of Open Access Journals (Sweden)

    Alessia Balestrini

    2013-06-01

    Full Text Available Single-ended double-strand breaks (DSBs are a common form of spontaneous DNA break, generated when the replisome encounters a discontinuity in the DNA template. Given their prevalence, understanding the mechanisms governing the fate(s of single-ended DSBs is important. We describe the influence of the Ku heterodimer and Mre11 nuclease activity on processing of single-ended DSBs. Separation-of-function alleles of yku70 were derived that phenocopy Ku deficiency with respect to single-ended DSBs but remain proficient for NHEJ. The Ku mutants fail to regulate Exo1 activity, and bypass the requirement for Mre11 nuclease activity in the repair of camptothecin-induced single-ended DSBs. Ku mutants exhibited reduced affinity for DNA ends, manifest as both reduced end engagement and enhanced probability of diffusing inward on linear DNA. This study reveals an interplay between Ku and Mre11 in the metabolism of single-ended DSBs that is distinct from repair pathway choice at double-ended DSBs.

  7. The Ku70/80 ring in Non-Homologous End-Joining

    DEFF Research Database (Denmark)

    Kragelund, Birthe Brandt; Weterings, Eric; Hartmann-Petersen, Rasmus

    2016-01-01

    /80 heterodimer is a key-player in the NHEJ pathway and binds to DNA termini with high affinity, where it helps to protect DNA ends from degradation and to recruit other NHEJ factors required for repair. The mechanism of Ku70/80 detachment from the DNA helix after completion of DNA repair is incompletely......Non-homologous end-joining (NHEJ) is an essential DNA double strand break repair pathway during all cell cycle stages. Deficiency in NHEJ factors can lead to accumulation of unrepaired DNA breaks or faulty DNA repair, which may ultimately result in cell death, senescence or carcinogenesis. The Ku70...... understood. Some data suggest that certain DNA repair factors are ubiquitylated and targeted for proteasomal degradation after repair. Recent studies suggest that Ku80 is conjugated to lysine48-linked ubiquitin chains by the Skp1-Cullin-F-box (SCF) complex and/or the RING finger protein 8 (RNF8) ubiquitin-protein...

  8. Pohon pásového dopravníku pro transport uhlí

    OpenAIRE

    Kliš, Kamil

    2013-01-01

    Diplomová práce se zabývá návrhem pohonu pásového dopravníku pro transport uhlí. Práce obsahuje nezbytné výpočty dle norem potřebné k určení vhodných komponentů pásového dopravníku. Cílem diplomové práce bylo navrhnout pohon pásového dopravníku, všech jeho potřebných komponentů včetně návrhem rámu pohonu a vytvoření výkresové dokumentace. This diploma thesis deals with designing a drivetrain for a coal belt conveyor. Thesis contains necessary calculations according to norms needed for dete...

  9. Uloga kućnih ljubimaca u socioemocionalnom  razvoju djece školskog uzrasta

    OpenAIRE

    Smojver-Ažić, Sanja; Topalović, Zorica

    2010-01-01

    Rezultati istraživanja potvrđuju kako je odrastanje uz kućnoga ljubimca povezano sa socioemocionalnim razvojem djece. Cilj ovoga istraživanja bio je ispitati odnos u kojemu stoje privrženost majci, privrženost kućnomu ljubimcu i empatija, socijalna kompetencija i usamljenost. U istraživanju je sudjelovalo 480 učenika četvrtoga, šestoga i osmoga razreda osnovnih škola u Istri (226 djevojčica i 254 dječaka) te njihovi roditelji. U ispitanom uzorku 63 % djece ima jednoga ili više kućnih ljubi...

  10. Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage ▿

    Science.gov (United States)

    Foster, Steven S.; Balestrini, Alessia; Petrini, John H. J.

    2011-01-01

    The Mre11 complex is a central component of the DNA damage response, with roles in damage sensing, molecular bridging, and end resection. We have previously shown that in Saccharomyces cerevisiae, Ku70 (yKu70) deficiency reduces the ionizing radiation sensitivity of mre11Δ mutants. In this study, we show that yKu70 deficiency suppressed the camptothecin (CPT) and methyl methanesulfonate (MMS) sensitivity of nuclease-deficient mre11-3 and sae2Δ mutants in an Exo1-dependent manner. CPT-induced G2/M arrest, γ-H2AX persistence, and chromosome breaks were elevated in mre11-3 mutants. These outcomes were reduced by yKu70 deficiency. Given that the genotoxic effects of CPT are manifest during DNA replication, these data suggest that Ku limits Exo1-dependent double-strand break (DSB) resection during DNA replication, inhibiting the initial processing steps required for homology-directed repair. We propose that Mre11 nuclease- and Sae2-dependent DNA end processing, which initiates DSB resection prevents Ku from engaging DSBs, thus promoting Exo1-dependent resection. In agreement with this idea, we show that Ku affinity for binding to short single-stranded overhangs is much lower than for blunt DNA ends. Collectively, the data define a nonhomologous end joining (NHEJ)-independent, S-phase-specific function of the Ku heterodimer. PMID:21876003

  11. Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection*

    Science.gov (United States)

    Krasner, Danielle S.; Daley, James M.; Sung, Patrick; Niu, Hengyao

    2015-01-01

    DNA double-strand breaks can be eliminated via non-homologous end joining or homologous recombination. Non-homologous end joining is initiated by the association of Ku with DNA ends. In contrast, homologous recombination entails nucleolytic resection of the 5′-strands, forming 3′-ssDNA tails that become coated with replication protein A (RPA). Ku restricts end access by the resection nuclease Exo1. It is unclear how partial resection might affect Ku engagement and Exo1 restriction. Here, we addressed these questions in a reconstituted system with yeast proteins. With blunt-ended DNA, Ku protected against Exo1 in a manner that required its DNA end-binding activity. Despite binding poorly to ssDNA, Ku could nonetheless engage a 5′-recessed DNA end with a 40-nucleotide (nt) ssDNA overhang, where it localized to the ssDNA-dsDNA junction and efficiently blocked resection by Exo1. Interestingly, RPA could exclude Ku from a partially resected structure with a 22-nt ssDNA tail and thus restored processing by Exo1. However, at a 40-nt tail, Ku remained stably associated at the ssDNA-dsDNA junction, and RPA simultaneously engaged the ssDNA region. We discuss a model in which the dynamic equilibrium between Ku and RPA binding to a partially resected DNA end influences the timing and efficiency of the resection process. PMID:26067273

  12. Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery

    Science.gov (United States)

    Tian, Xi; Lara, Haydee; Wagner, Kyle T.; Saripalli, Srinivas; Hyder, Syed Nabeel; Foote, Michael; Sethi, Manish; Wang, Edina; Caster, Joseph M.; Zhang, Longzhen; Wang, Andrew Z.

    2015-11-01

    Radiotherapy is a key component of cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic index of radiotherapy. DNA double-strand repair inhibitors (DSBRIs) are among the most promising agents to improve radiotherapy. However, their clinical translation has been limited by their potential toxicity to normal tissue. Recent advances in nanomedicine offer an opportunity to overcome this limitation. In this study, we aim to demonstrate the proof of principle by developing and evaluating nanoparticle (NP) formulations of KU55933, a DSBRI. We engineered a NP formulation of KU55933 using nanoprecipitation method with different lipid polymer nanoparticle formulation. NP KU55933 using PLGA formulation has the best loading efficacy as well as prolonged drug release profile. We demonstrated that NP KU55933 is a potent radiosensitizer in vitro using clonogenic assay and is more effective as a radiosensitizer than free KU55933 in vivo using mouse xenograft models of non-small cell lung cancer (NSCLC). Western blots and immunofluorescence showed NP KU55933 exhibited more prolonged inhibition of DNA repair pathway. In addition, NP KU55933 leads to lower skin toxicity than KU55933. Our study supports further investigations using NP to deliver DSBRIs to improve cancer radiotherapy treatment.

  13. Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair

    NARCIS (Netherlands)

    Y.J. Choi (Yong Jun); H. Li (Han); M.Y. Son (Mi Young); X.-H. Wang (Xiao-Hong); J.L. Fornsaglio (Jamie L.); R.W. Sobol (Robert W.); M. Lee (Moonsook); J. Vijg (Jan); S. Imholz (Sandra); M.E.T. Dollé (Martijn); H. van Steeg (Harry); E. Reiling (Erwin); P. Hasty (Paul)

    2014-01-01

    textabstractKu70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS) to repair DNA double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway. As expected mutating these genes in mice caused a similar DSB

  14. Analysis of metals in asphaltenes of KU-46 by PIXE analysis; Analisis de metales en asfaltenos de crudo mexicano KU-46 por PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Navidad G, P.; Pina L, L.I.; Lopez M, J.; Ramirez T, J.J.; Aspiazu F, J.A.; Romero G, E.T. [Gerencia de Ciencias Basicas, Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    The content of metals of the asphaltenes obtained from the KU-46 mexican crude with n-heptane was evaluated. The found metals in higher concentration are transition metals as well as the vanadium, nickel, copper and zinc. Moreover the sulfur in high concentrations was quantified. The metallic content of the asphaltenes revealed that the crude contains a lower quantity of metals unlike the vacuum residue previously analysed. (Author)

  15. Kuřim–the largest small town in the South-Moravian Region (Czechia)

    Czech Academy of Sciences Publication Activity Database

    Vaishar, Antonín

    2015-01-01

    Roč. 8, č. 8 (2015), s. 135-147 ISSN 2084-5456 Institutional support: RVO:68145535 Keywords : small town * suburbanization * Kuřim Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://annalesgeo.up.krakow.pl/article/view/2839/2502

  16. A Ku-band magnetically insulated transmission line oscillator with overmoded slow-wave-structure

    Science.gov (United States)

    Jiang, Tao; He, Jun-Tao; Zhang, Jian-De; Li, Zhi-Qiang; Ling, Jun-Pu

    2016-12-01

    In order to enhance the power capacity, an improved Ku-band magnetically insulated transmission line oscillator (MILO) with overmoded slow-wave-structure (SWS) is proposed and investigated numerically and experimentally. The analysis of the dispersion relationship and the resonant curve of the cold test indicate that the device can operate at the near π mode of the TM01 mode, which is useful for mode selection and control. In the particle simulation, the improved Ku-band MILO generates a microwave with a power of 1.5 GW and a frequency of 12.3 GHz under an input voltage of 480 kV and input current of 42 kA. Finally, experimental investigation of the improved Ku-band MILO is carried out. A high-power microwave (HPM) with an average power of 800 MW, a frequency of 12.35 GHz, and pulse width of 35 ns is generated under a diode voltage of 500 kV and beam current of 43 kA. The consistency between the experimental and simulated far-field radiation pattern confirms that the operating mode of the improved Ku-band MILO is well controlled in π mode of the TM01 mode. Project supported partly by the National Natural Science Foundation of China (Grant No. 61171021).

  17. Development of intense terahertz coherent synchrotron radiation at KU-FEL

    Energy Technology Data Exchange (ETDEWEB)

    Sei, Norihiro, E-mail: sei.n@aist.go.jp [Research Institute for Measurement and Analytical Instrumentation, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Umezono, Tsukuba, Ibaraki 305-8568 (Japan); Zen, Heishun; Ohgaki, Hideaki [Institute for Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan)

    2016-10-01

    We produced intense coherent synchrotron radiation (CSR) in the terahertz (THz) region using an S-band linac at the Kyoto University Free Electron Laser (KU-FEL), which is a mid-infrared free-electron laser facility. The CSR beam was emitted from short-pulse electron bunches compressed by a 180° arc, and was transferred to air at a large solid angle of 0.10 rad. The measured CSR energy was 55 μJ per 7 μs macropulse, and KU-FEL was one of the most powerful CSR sources in normal conducting linear accelerator facilities. The CSR spectra were measured using an uncooled pyroelectric detector and a Michelson-type interferometer designed specifically for the KU-FEL electron beam, and had a maximum at a frequency of 0.11 THz. We found that adjusting the energy slit enhanced the CSR energy and shortened the electron beam bunch length in the CSR spectra measurements. Our results demonstrated that the efficient use of the energy slit can help improve the characteristics of CSR. - Highlights: • We have developed intense coherent synchrotron radiation (CSR) at KU-FEL. • The elevation angle of the CSR was correctly measured by a new technique. • The CSR power extracted to the air was 55 μJ per 7 μs macropulse. • It was demonstrated that an energy slit was effective to improve the CSR properties.

  18. An integrated Ka/Ku-band payload for personal, mobile and private business communications

    Science.gov (United States)

    Hayes, Edward J.; Keelty, J. Malcolm

    1991-01-01

    The Canadian Department of Communications has been studying options for a government-sponsored demonstration payload to be launched before the end of the century. A summary of the proposed system concepts and network architectures for providing an advanced private business network service at Ku-band and personal and mobile communications at Ka-band is presented. The system aspects addressed include coverage patterns, traffic capacity, and grade of service, multiple access options as well as special problems, such as Doppler in mobile applications. Earth terminal types and the advanced payload concept proposed in a feasibility study for the demonstration mission are described. This concept is a combined Ka-band/Ku-band payload which incorporates a number of advanced satellite technologies including a group demodulator to convert single-channel-per-carrier frequency division multiple access uplink signals to a time division multiplex downlink, on-board signal regeneration, and baseband switching to support packet switched data operation. The on-board processing capability of the payload provides a hubless VSAT architecture which permits single-hop full mesh interconnectivity. The Ka-band and Ku-band portions of the payload are fully integrated through an on-board switch, thereby providing the capability for fully integrated services, such as using the Ku-band VSAT terminals as gateway stations for the Ka-band personal and mobile communications services.

  19. Development of intense terahertz coherent synchrotron radiation at KU-FEL

    International Nuclear Information System (INIS)

    Sei, Norihiro; Zen, Heishun; Ohgaki, Hideaki

    2016-01-01

    We produced intense coherent synchrotron radiation (CSR) in the terahertz (THz) region using an S-band linac at the Kyoto University Free Electron Laser (KU-FEL), which is a mid-infrared free-electron laser facility. The CSR beam was emitted from short-pulse electron bunches compressed by a 180° arc, and was transferred to air at a large solid angle of 0.10 rad. The measured CSR energy was 55 μJ per 7 μs macropulse, and KU-FEL was one of the most powerful CSR sources in normal conducting linear accelerator facilities. The CSR spectra were measured using an uncooled pyroelectric detector and a Michelson-type interferometer designed specifically for the KU-FEL electron beam, and had a maximum at a frequency of 0.11 THz. We found that adjusting the energy slit enhanced the CSR energy and shortened the electron beam bunch length in the CSR spectra measurements. Our results demonstrated that the efficient use of the energy slit can help improve the characteristics of CSR. - Highlights: • We have developed intense coherent synchrotron radiation (CSR) at KU-FEL. • The elevation angle of the CSR was correctly measured by a new technique. • The CSR power extracted to the air was 55 μJ per 7 μs macropulse. • It was demonstrated that an energy slit was effective to improve the CSR properties.

  20. Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70

    DEFF Research Database (Denmark)

    Xing, Mengtan; Bjørås, Magnar; Daniel, Jeremy A

    2017-01-01

    DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds DSBs and thus promotes recruitment of accessory downstream NHEJ factors XLF......, PAXX, DNA-PKcs, Artemis and other core subunits, XRCC4 and DNA Ligase 4 (Lig4). In the absence of core C-NHEJ factors, DNA repair can be performed by Alternative End-Joining, which likely depends on DNA Ligase 1 and DNA Ligase 3. Genetic inactivation of C-NHEJ factors, such as Ku70, Ku80, XLF, PAXX...... with severe apoptosis in the central nervous system. Here, we demonstrate that inactivation of the Ku70 gene rescues the synthetic lethality between XLF and DNA-PKcs, resulting in triple knockout mice that are indistinguishable from Ku70-deficient littermates by size or levels of genomic instability. Moreover...

  1. Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648.

    Science.gov (United States)

    Hinrichsen, Inga; Ackermann, Anne; Düding, Tonja; Graband, Annika; Filmann, Natalie; Plotz, Guido; Zeuzem, Stefan; Brieger, Angela

    2017-07-01

    Germline mutations of MLH1 are responsible for tumor generation in nearly 50% of patients with Lynch Syndrome, and around 15% of sporadic colorectal cancers show MLH1-deficiency due to promotor hypermethylation. Although these tumors are of lower aggressiveness the benefit for these patients from standard chemotherapy is still under discussion. Recently, it was shown that the sensitivity to the DNA-PKcs inhibitor KU60648 is linked to loss of the MMR protein MSH3. However, loss of MSH3 is rather secondary, as a consequence of MMR-deficiency, and frequently detectable in MLH1-deficient tumors. Therefore, we examined the expression of MLH1, MSH2, MSH6, and MSH3 in different MMR-deficient and proficient cell lines and determined their sensitivity to KU60648 by analyzing cell viability and survival. MLH1-dependent ability of double strand break (DSB) repair was monitored after irradiation via γH2AX detection. A panel of 12 colon cancer cell lines, two pairs of cells, where MLH1 knock down was compared to controls with the same genetic background, and one MLH1-deficient cell line where MLH1 was overexpressed, were included. In summary, we found that MLH1 and/or MSH3-deficient cells exhibited a significantly higher sensitivity to KU60648 than MMR-proficient cells and that overexpression of MLH1 in MLH1-deficient cells resulted in a decrease of cell sensitivity. KU60648 efficiency seems to be associated with reduced DSB repair capacity. Since the molecular testing of colon tumors for MLH1 expression is a clinical standard we believe that MLH1 is a much better marker and a greater number of patients would benefit from KU60648 treatment. © 2017 Wiley Periodicals, Inc.

  2. DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Seho [Department of Life Science, Dongguk Univ-Seoul, Seoul 100-715 (Korea, Republic of); Lim, Chunghun [Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea, Republic of); Lee, Jae Young [Department of Life Science, Dongguk Univ-Seoul, Seoul 100-715 (Korea, Republic of); Song, Yoon-Jae [Department of Life Science, Kyungwon University, Seongnam-Si, Kyeonggi-Do 461-701 (Korea, Republic of); Park, Junsoo [Division of Biological Science and Technology, Yonsei University, Wonju 220-100 (Korea, Republic of); Choe, Joonho [Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea, Republic of); Seo, Taegun, E-mail: tseo@dongguk.edu [Department of Life Science, Dongguk Univ-Seoul, Seoul 100-715 (Korea, Republic of)

    2010-04-16

    During latent infection, latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays important roles in episomal persistence and replication. Several host factors are associated with KSHV latent replication. Here, we show that the catalytic subunit of DNA protein kinase (DNA-PKcs), Ku70, and Ku86 bind the N-terminal region of LANA. LANA was phosphorylated by DNA-PK and overexpression of Ku70, but not Ku86, impaired transient replication. The efficiency of transient replication was significantly increased in the HCT116 (Ku86 +/-) cell line, compared to the HCT116 (Ku86 +/+) cell line, suggesting that the DNA-PK/Ku complex negatively regulates KSHV latent replication.

  3. DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication

    International Nuclear Information System (INIS)

    Cha, Seho; Lim, Chunghun; Lee, Jae Young; Song, Yoon-Jae; Park, Junsoo; Choe, Joonho; Seo, Taegun

    2010-01-01

    During latent infection, latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays important roles in episomal persistence and replication. Several host factors are associated with KSHV latent replication. Here, we show that the catalytic subunit of DNA protein kinase (DNA-PKcs), Ku70, and Ku86 bind the N-terminal region of LANA. LANA was phosphorylated by DNA-PK and overexpression of Ku70, but not Ku86, impaired transient replication. The efficiency of transient replication was significantly increased in the HCT116 (Ku86 +/-) cell line, compared to the HCT116 (Ku86 +/+) cell line, suggesting that the DNA-PK/Ku complex negatively regulates KSHV latent replication.

  4. Volba idolů ve školním věku (Pop-Pantheon)

    OpenAIRE

    Ryba, Zdeněk

    2016-01-01

    Title: Idolization In The School Age (Pop-Pantheon) Author: Zdeněk Ryba Department: Department of Psychology Supervizor: doc. PhDr. Miloš Kučera, CSc. The main theme of this thesis is basic-school-age children choice of idols. The work is a part of Miloš Kučera research at Faculty of Education UK and it follows up the Mikšíček (1999) and Kravcová (2008) conclusions in their diploma thesis and short Kučera's contribution. The goal of this thesis is to make a database of idols and to create mod...

  5. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.

    Science.gov (United States)

    Manis, J P; Gu, Y; Lansford, R; Sonoda, E; Ferrini, R; Davidson, L; Rajewsky, K; Alt, F W

    1998-06-15

    Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement. Ku70 and Ku80 form a DNA end-binding complex required for DNA double strand break repair and V(D)J recombination. Ku70(-/-) (K70T) mice, like recombination activating gene (RAG)-1- or RAG-2-deficient (R1T or R2T) mice, have impaired B and T cell development at an early progenitor stage, which is thought to result at least in part from defective V(D)J recombination (Gu, Y., K.J. Seidl, G.A. Rathbun, C. Zhu, J.P. Manis, N. van der Stoep, L. Davidson, H.L. Cheng, J.M. Sekiguchi, K. Frank, et al. 1997. Immunity. 7:653-665; Ouyang, H., A. Nussenzweig, A. Kurimasa, V.C. Soares, X. Li, C. Cordon-Cardo, W. Li, N. Cheong, M. Nussenzweig, G. Iliakis, et al. 1997. J. Exp. Med. 186:921-929). Therefore, to examine the potential role of Ku70 in CSR, we generated K70T mice that carry a germline Ig HC locus in which the JH region was replaced with a functionally rearranged VH(D)JH and Ig lambda light chain transgene (referred to as K70T/HL mice). Previously, we have shown that B cells from R1T or R2T mice carrying these rearranged Ig genes (R1T/HL or R2T/HL mice) can undergo CSR to IgG isotypes (Lansford, R., J. Manis, E. Sonoda, K. Rajewsky, and F. Alt. 1998. Int. Immunol. 10:325-332). K70T/HL mice had significant numbers of peripheral surface IgM+ B cells, which generated serum IgM levels similar to those of R2T/HL mice. However, in contrast to R2T/HL mice, K70T/HL mice had no detectable serum IgG isotypes. In vitro culture of K70T/HL B cells with agents that induce CSR in normal or R2T/HL B cells did lead to the induction of germline CH transcripts, indicating that initial signaling pathways for CSR were intact in K70T/HL cells. However, treatment with such agents did not lead to detectable CSR by K70T/HL B cells, and instead, led to cell death within 72 h. We conclude that Ku70 is required for the generation of B cells that have

  6. Archaeological investigations at Helme castle / Arvi Haak

    Index Scriptorium Estoniae

    Haak, Arvi

    2007-01-01

    Radioaktiivsüsiniku meetodil dateeriti linnuseõuele rajatud kaevandist leitu aastatesse 1210-1288. Eelviikingi- ja viikingiajast pärit söestunud puidujäätmete leidmine ei luba muinaslinnuse olemasolu Helmes täielikult välistada

  7. Entrepreneurship policy in Estonia / Arvi Kuura

    Index Scriptorium Estoniae

    Kuura, Arvi

    2006-01-01

    Ülevaade Eesti ettevõtluspoliitika ja seda teostavate institutsioonide kujunemisest, poliitika ja institutsioonide analüüs. Teoreetiliseks lähtekohaks on, et väikeettevõtluspoliitika ja ettevõtluspoliitika ole samastatavad

  8. Energeetikafoorum "Quo vadis, Eesti energeetika?" / Arvi Hamburg

    Index Scriptorium Estoniae

    Hamburg, Arvi, 1948-

    2006-01-01

    Tallinna Tehnikaülikoolis 27. aprillil 2006. a. Ühiskondliku Leppe Sihtasutuse, TTÜ, Eesti Teadlaste Liidu ja Eesti Inseneride Liidu korraldatud foorumist. Avaettekandega esines president Arnold Rüütel

  9. Energeetikafoorum "Quo vadis, Eesti energeetika?" / Arvi Hamburg

    Index Scriptorium Estoniae

    Hamburg, Arvi, 1948-

    2006-01-01

    Tallinna Tehnikaülikoolis 27. aprillil 2006. a. Ühiskondliku Leppe Sihtasutuse, Tallinna Tehnikaülikooli, Eesti Teadlaste Liidu ja Eesti Inseneride Liidu korraldatud foorumist. Avaettekandega esines foorumil president Arnold Rüütel

  10. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA

    International Nuclear Information System (INIS)

    Smider, V.; Rathmell, W.K.; Chu, G.; Lieber, M.R.

    1994-01-01

    Three genetic complementation groups of rodent cells are defective for both repair of x-ray-induced double-strand breaks and V(D)J recombination. Cells from one group lack a DNA end-binding activity that is biochemically and antigenically similar to the Ku autoantigen. Transfection of complementary DNA (cDNA) that encoded the 86-kilodalton subunit of Ku rescued these mutant cells for DNA end-binding activity, x-ray resistance, and V(D)J recombination activity. These results establish a role for Ku in DNA repair and recombination. Furthermore, as a component of a DNA-dependent protein kinase, Ku may initiate a signaling pathway induced by DNA damage

  11. Ku-mediated coupling of DNA cleavage and repair during programmed genome rearrangements in the ciliate Paramecium tetraurelia.

    Directory of Open Access Journals (Sweden)

    Antoine Marmignon

    2014-08-01

    Full Text Available During somatic differentiation, physiological DNA double-strand breaks (DSB can drive programmed genome rearrangements (PGR, during which DSB repair pathways are mobilized to safeguard genome integrity. Because of their unique nuclear dimorphism, ciliates are powerful unicellular eukaryotic models to study the mechanisms involved in PGR. At each sexual cycle, the germline nucleus is transmitted to the progeny, but the somatic nucleus, essential for gene expression, is destroyed and a new somatic nucleus differentiates from a copy of the germline nucleus. In Paramecium tetraurelia, the development of the somatic nucleus involves massive PGR, including the precise elimination of at least 45,000 germline sequences (Internal Eliminated Sequences, IES. IES excision proceeds through a cut-and-close mechanism: a domesticated transposase, PiggyMac, is essential for DNA cleavage, and DSB repair at excision sites involves the Ligase IV, a specific component of the non-homologous end-joining (NHEJ pathway. At the genome-wide level, a huge number of programmed DSBs must be repaired during this process to allow the assembly of functional somatic chromosomes. To understand how DNA cleavage and DSB repair are coordinated during PGR, we have focused on Ku, the earliest actor of NHEJ-mediated repair. Two Ku70 and three Ku80 paralogs are encoded in the genome of P. tetraurelia: Ku70a and Ku80c are produced during sexual processes and localize specifically in the developing new somatic nucleus. Using RNA interference, we show that the development-specific Ku70/Ku80c heterodimer is essential for the recovery of a functional somatic nucleus. Strikingly, at the molecular level, PiggyMac-dependent DNA cleavage is abolished at IES boundaries in cells depleted for Ku80c, resulting in IES retention in the somatic genome. PiggyMac and Ku70a/Ku80c co-purify as a complex when overproduced in a heterologous system. We conclude that Ku has been integrated in the Paramecium

  12. Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.

    Science.gov (United States)

    Charbonnel, Cyril; Gallego, Maria E; White, Charles I

    2010-10-01

    Double-strand breakage (DSB) of DNA involves loss of information on the two strands of the DNA fibre and thus cannot be repaired by simple copying of the complementary strand which is possible with single-strand DNA damage. Homologous recombination (HR) can precisely repair DSB using another copy of the genome as template and non-homologous recombination (NHR) permits repair of DSB with little or no dependence on DNA sequence homology. In addition to the well-characterised Ku-dependent non-homologous end-joining (NHEJ) pathway, much recent attention has been focused on Ku-independent NHR. The complex interrelationships and regulation of NHR pathways remain poorly understood, even more so in the case of plants, and we present here an analysis of Ku-dependent and Ku-independent repair of DSB in Arabidopsis thaliana. We have characterised an Arabidopsis xrcc1 mutant and developed quantitative analysis of the kinetics of appearance and loss of γ-H2AX foci as a tool to measure DSB repair in dividing root tip cells of γ-irradiated plants in vivo. This approach has permitted determination of DSB repair kinetics in planta following a short pulse of γ-irradiation, establishing the existence of a Ku-independent, Xrcc1-dependent DSB repair pathway. Furthermore, our data show a role for Ku80 during the first minutes post-irradiation and that Xrcc1 also plays such a role, but only in the absence of Ku. The importance of Xrcc1 is, however, clearly visible at later times in the presence of Ku, showing that alternative end-joining plays an important role in DSB repair even in the presence of active NHEJ. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

  13. Experimental research on Ku-band magnetically insulated transmission line oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Tao; Zhang, Jiande; He, Juntao; Li, Zhiqiang; Ling, Junpu [College of Optoelectric Science and Engineering, National University of Defense Technology, Hunan 410073 (China)

    2015-10-15

    An improved Ku-band magnetically insulated transmission line oscillator is proposed and investigated experimentally. In the particle-in-cell simulation, the Ku-band MILO generates the microwave with a power of 1.62 GW and a frequency of 13 GHz at the input voltage of 474 kV. The device is fabricated based on the simulation results, and an experiment system is designed. In the preliminary experiments, output microwave with frequency of 13.02 GHz, power of 150 MW, and pulse width of 17 ns is generated, under the diode voltage of 450 kV. Analysis on the experiment results shows that plasma produced due to the large current hitting to the outside of the collection tank is the essential cause for the low amplitude of the microwave power and short pulse width.

  14. Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.

    Directory of Open Access Journals (Sweden)

    Mahvash Zakikhani

    Full Text Available KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM, an important tumor suppressor gene with key roles in DNA repair. Unexpectedly for an inhibitor of a tumor suppressor gene, KU-55933 reduces proliferation. In view of prior preliminary evidence suggesting defective mitochondrial function in cells of patients with Ataxia Telangiectasia (AT, we examined energy metabolism of cells treated with KU-55933. The compound increased AMPK activation, glucose uptake and lactate production while reducing mitochondrial membrane potential and coupled respiration. The stimulation of glycolysis by KU-55933 did not fully compensate for the reduction in mitochondrial functions, leading to decreased cellular ATP levels and energy stress. These actions are similar to those previously described for the biguanide metformin, a partial inhibitor of respiratory complex I. Both compounds decreased mitochondrial coupled respiration and reduced cellular concentrations of fumarate, malate, citrate, and alpha-ketogluterate. Succinate levels were increased by KU-55933 levels and decreased by metformin, indicating that the effects of ATM inhibition and metformin are not identical. These observations suggest a role for ATM in mitochondrial function and show that both KU-55933 and metformin perturb the TCA cycle as well as oxidative phosphorylation.

  15. Analysis of metals in asphaltenes of KU-46 by PIXE analysis

    International Nuclear Information System (INIS)

    Navidad G, P.; Pina L, L.I.; Lopez M, J.; Ramirez T, J.J.; Aspiazu F, J.A.; Romero G, E.T.

    2002-01-01

    The content of metals of the asphaltenes obtained from the KU-46 mexican crude with n-heptane was evaluated. The found metals in higher concentration are transition metals as well as the vanadium, nickel, copper and zinc. Moreover the sulfur in high concentrations was quantified. The metallic content of the asphaltenes revealed that the crude contains a lower quantity of metals unlike the vacuum residue previously analysed. (Author)

  16. Radiation effects on radiation-hardened KU and KS-4V optical fibres

    International Nuclear Information System (INIS)

    Ivanov, A.A.; Tugarinov, S.N.; Kaschuck, Y.A.; Krasilnikov, A.V.; Bender, S.E.

    1999-01-01

    The aim of this work was to test the un-pretreated and the hardened (H 2 -loaded and pre-irradiated) KS-4V and KU optical fibres in reactor environment by in-situ measurements of both the radiation-induced loss and the luminescence in the visible spectral region. Both the radio-luminescent and the transmission spectra were in-situ detected during irradiation by charge-coupled-device (CCD) linear detector in the visible spectral region of 400 to 700 nm. The radiation induced loss spectra at the fast neutron fluence of 2*10 6 n/cm 2 shows the hardened, H 2 -loading and pre-irradiating effects in the both KU and KS-4V fibres. KU un-pretreated fibre shows a big radiation absorption band of non-bridging oxygen centered at the wavelength of 630 nm. It appears that the KS-4V hardened fibre has a specific point in the loss spectrum in the vicinity of 460 nm. Other measurements were performed, particularly after reactor shutdown and at 3 different neutron fluences with constant neutron flux after restarting

  17. Oxidative DNA Damage in Neurons: Implication of Ku in Neuronal Homeostasis and Survival

    Directory of Open Access Journals (Sweden)

    Daniela De Zio

    2012-01-01

    Full Text Available Oxidative DNA damage is produced by reactive oxygen species (ROS which are generated by exogenous and endogenous sources and continuously challenge the cell. One of the most severe DNA lesions is the double-strand break (DSB, which is mainly repaired by nonhomologous end joining (NHEJ pathway in mammals. NHEJ directly joins the broken ends, without using the homologous template. Ku70/86 heterodimer, also known as Ku, is the first component of NHEJ as it directly binds DNA and recruits other NHEJ factors to promote the repair of the broken ends. Neurons are particularly metabolically active, displaying high rates of transcription and translation, which are associated with high metabolic and mitochondrial activity as well as oxygen consumption. In such a way, excessive oxygen radicals can be generated and constantly attack DNA, thereby producing several lesions. This condition, together with defective DNA repair systems, can lead to a high accumulation of DNA damage resulting in neurodegenerative processes and defects in neurodevelopment. In light of recent findings, in this paper, we will discuss the possible implication of Ku in neurodevelopment and in mediating the DNA repair dysfunction observed in certain neurodegenerations.

  18. DASCH ON KU Cyg: A ∼ 5 YEAR DUST ACCRETION EVENT IN ∼ 1900

    International Nuclear Information System (INIS)

    Tang Sumin; Grindlay, Jonathan; Los, Edward; Servillat, Mathieu

    2011-01-01

    KU Cyg is an eclipsing binary consisting of an F-type star accreting through a large accretion disk from a K5III red giant. Here we present the discovery of a 5 year dip around 1900 found from its 100 year DASCH light curve. It showed a ∼0.5 mag slow fading from 1899 to 1903 and brightened back around 1904 on a relatively shorter timescale. The light curve shape of the 1899-1904 fading-brightening event differs from the dust production and dispersion process observed in R Coronae Borealis stars, which usually has a faster fading and slower recovery, and for KU Cyg is probably related to the accretion disk surrounding the F star. The slow fading in KU Cyg is probably caused by increases in dust extinction in the disk, and the subsequent quick brightening may be due to the evaporation of dust transported inward through the disk. The extinction excess which caused the fading may arise from increased mass transfer rate in the system or from dust clump ejections from the K giant.

  19. Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Fumio, E-mail: fnomura@faculty.chiba-u.jp [Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University and Divisions of Laboratory Medicine, Clinical Genetics and Proteomics, Chiba University Hospital, Chiba (Japan); Sogawa, Kazuyuki; Noda, Kenta; Seimiya, Masanori; Matsushita, Kazuyuki; Miura, Toshihide [Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University and Divisions of Laboratory Medicine, Clinical Genetics and Proteomics, Chiba University Hospital, Chiba (Japan); Tomonaga, Takeshi [Laboratory of Proteome Research, National Institute of Biomedical Innovation, Ibaraki (Japan); Yoshitomi, Hideyuki [Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba (Japan); Imazeki, Fumio [Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba (Japan); Takizawa, Hirotaka [Kashiwado Clinic in Port-Square of the Kashiwado Memorial Foundation, Chiba (Japan); Mogushi, Kaoru [Information Center for Medical Sciences, Tokyo Dental and Medical University, Tokyo (Japan); Miyazaki, Masaru [Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba (Japan); Yokosuka, Osamu [Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba (Japan)

    2012-05-18

    Highlights: Black-Right-Pointing-Pointer Overexpression of Ku86 in human liver cancer was shown by immunohistochemistry. Black-Right-Pointing-Pointer Serum anti-Ku86 was significantly elevated in early hepatocellular carcinoma. Black-Right-Pointing-Pointer Anti-Ku86 may be more sensitive than the conventional markers for early detection. Black-Right-Pointing-Pointer Serum anti-Ku86 significantly decreased after surgical resection of liver tumors. Black-Right-Pointing-Pointer Elevation of serum anti-Ku86 in other non-liver solid tumors was minimal. -- Abstract: Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is one of the most common cancers worldwide and the third most common cause of cancer-related death. Imaging studies including ultrasound and computed tomography are recommended for early detection of HCC, but they are operator dependent, costly and involve radiation. Therefore, there is a need for simple and sensitive serum markers for the early detection of hepatocellular carcinoma (HCC). In our recent proteomic studies, a number of proteins overexpressed in HCC tissues were identified. We thought if the serum autoantibodies to these overexpressed proteins were detectable in HCC patients. Of these proteins, we focused on Ku86, a nuclear protein involved in multiple biological processes and aimed to assess the diagnostic value of serum anti-Ku86 in the early detection of HCC. Serum samples were obtained prior to treatment from 58 consecutive patients with early or relatively early hepatitis C virus (HCV)-related HCC and 137 patients with HCV-related liver cirrhosis without evidence of HCC. Enzyme immunoassays were used to measure serum levels of autoantibodies. Serum levels of anti-Ku86 antibodies were significantly elevated in HCC patients compared to those in liver cirrhosis patients (0.41 {+-} 0.28 vs. 0.18 {+-} 0.08 Abs at 450 nm, P < 0001). Setting the cut-off level to give 90% specificity, anti-Ku86 was positive in 60.7% of

  20. Molecular characterization of resistant chronic lymphocytic leukemia (CLL): function of a new phosphorylated form of Ku70

    International Nuclear Information System (INIS)

    Saad, Lina

    2013-01-01

    We have identified a new form of phospho-S27-S33-Ku70 constitutively over expressed in a subset of chronic lymphocytic leukemia (CLL) B cells resistant to apoptosis induced by DNA double strand breaks (DSB). Ku70 is one of the essential proteins involved in the maintenance of genomic stability through its role in DNA double strand break repair (non-homologous end-joining, NHEJ) and in telomeric protection. Laboratory previously established that resistant CLL cells disclose an up-regulated NHEJ DNA repair and an impaired structure of telomeres. The goal of this thesis was to characterize the biological function(s) of this new form of Ku70. For this purpose we have constructed specific EBV-based vectors (siRNA / cDNA) enabling a simultaneous inhibition of endogenous Ku70 and an expression of different forms (mutated, wild, phospho-mimetic at ser27-33) of Ku70 resistant to siRNA. Thus, we showed: i) a strict co-localisation of phospho-Ku70 with γ-H2AX foci; ii) that DSB induces the phosphorylation of Ku70 within minutes after genotoxic stress in heterodimer complex Ku70/Ku80. This phosphorylation necessitates both the physical interaction and the activity of pS2056-DNA-PKcs and/or ATM, linking phospho-Ku70 to NHEJ-mediated DNA DSB repair; iii) cells expressing mutated A27-A33-Ku70 exhibit a delayed G2/M cell cycle arrest, slower kinetic of DNA repair, lower level of genotoxic stress-induced chromosomal aberrations, and a higher cellular impedance correlated with translocation of transcriptional factor β-catenin from cytoplasmic membrane to the nucleus. Together, these data unveil an involvement of phospho-Ku70 in fast and inaccurate DNA repair; new paradigm for NHEJ regulation and to the control of resistance and maintenance of malignant cells.In parallel, we have initiated experimental approaches to explore other potential roles of phospho-Ku70. Especially, we were interested to determine whether it could play a role in an initiation of cell senescence induced by

  1. Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation

    International Nuclear Information System (INIS)

    Suzuki, Keiji; Kodama, Seiji; Watanabe, Masami

    2010-01-01

    Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells.

  2. Double strand break rejoining by the Ku-dependent mechanism of non-homologous end-joining

    International Nuclear Information System (INIS)

    Jeggo, P.; Singleton, B.; Beamish, H.; Priestley, A.

    1999-01-01

    The DNA-dependent protein kinase functions in the repair of DNA double strand breaks (DSBs) and in V(D)J recombination. To gain insight into the function of DNA-PK in this process we have carried out a mutation analysis of Ku80 and DNA-PKcs. Mutations at multiple sites within the N-terminal two thirds of Ku80 result in loss of Ku70/80 interaction, loss of DNA end-binding activity and inability to complement Ku80 defective cell fines. In contrast, mutations in the carboxy terminal region of the protein do not impair DNA end-binding activity but decrease the ability of Ku to activate DNA-PK. To gain insight into important functional domains within DNA-PKcs, we have analysed defective mutants, including the mouse scid cell line, and the rodent mutants, ire-20 and V-3. Mutational changes in the carboxy terminal region have been identified in all cases. Our results strongly suggest that the C-terminus of DNA-PKcs is required for kinase activity. (author)

  3. Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Keiji, E-mail: kzsuzuki@nagasaki-u.ac.jp [Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Kodama, Seiji [Research Institute for Advanced Science and Technology, Osaka Prefecture University, 1-2 Gakuen-machi, Sakai 599-8570 (Japan); Watanabe, Masami [Kyoto University Research Reactor Institute, Kumatori-cho Sennan-gun, Osaka 590-0494 (Japan)

    2010-01-05

    Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells.

  4. The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove.

    Science.gov (United States)

    Kragelund, Birthe B; Weterings, Eric; Hartmann-Petersen, Rasmus; Keijzers, Guido

    2016-01-01

    Non-homologous end-joining (NHEJ) is an essential DNA double strand break repair pathway during all cell cycle stages. Deficiency in NHEJ factors can lead to accumulation of unrepaired DNA breaks or faulty DNA repair, which may ultimately result in cell death, senescence or carcinogenesis. The Ku70/80 heterodimer is a key-player in the NHEJ pathway and binds to DNA termini with high affinity, where it helps to protect DNA ends from degradation and to recruit other NHEJ factors required for repair. The mechanism of Ku70/80 detachment from the DNA helix after completion of DNA repair is incompletely understood. Some data suggest that certain DNA repair factors are ubiquitylated and targeted for proteasomal degradation after repair. Recent studies suggest that Ku80 is conjugated to lysine48-linked ubiquitin chains by the Skp1-Cullin-F-box (SCF) complex and/or the RING finger protein 8 (RNF8) ubiquitin-protein ligases, followed by rapid proteasomal degradation. In this review we address the structure and function of the Ku70/80 heterodimer and how ubiquitylation may affect the release of Ku70/80 from chromatin and its subsequent degradation via the ubiquitin-proteasome system.

  5. Izrada 3D modela kućišta centrifugalne pumpe

    OpenAIRE

    Hršak, Božidar; Golubić, Stjepan; Carek, Dalibor

    2012-01-01

    Prikazana je izrada 3D modela kućišta centrifugalne pumpe na temelju postojećeg 2D nacrta gotovog proizvoda primjenom sinkrone tehnologije 3D modeliranja, i reverzibilnog inženjeringa. Na temelju kreiranog 3D modela, predložene su moguće modifikacije postojeće izvedbe proizvoda. Provedene su analize zakrivljenosti površina, Bézierove krivulje modela i 3D geometrije. Prikazana je i mogućnost vizualizacije gotovog 3D modela na Web stranicama u cilju prezentiranja proizvoda budućim kupcima primj...

  6. Izrada 3D modela kućišta ravnog ventila DN 50

    OpenAIRE

    Hršak, Božidar; Golubić, Stjepan; Bošnjak, Matej

    2012-01-01

    Prikazana je izrada 3D modela kućišta centrifugalne pumpe na temelju postojećeg 2D nacrta gotovog proizvoda primjenom sinkrone tehnologije 3D modeliranja, i reverzibilnog inženjeringa. Na temelju kreiranog 3D modela, predložene su moguće modifikacije postojeće izvedbe proizvoda. Provedene su analize zakrivljenosti površina, Bézierove krivulje modela i 3D geometrije. Prikazana je i mogućnost vizualizacije gotovog 3D modela na Web stranicama u cilju prezentiranja proizvoda budućim kupcima primj...

  7. Chemical compatibility study of Cooley L18KU, Herculite, and Elephant Mat with Hanford tank waste

    International Nuclear Information System (INIS)

    Mercado, J.E.

    1998-01-01

    An independent chemical compatibility review of various wrapping and absorbent/padding materials was conducted to evaluate resistance to chemicals and constituents present in liquid waste from the Hanford underground tanks. These materials will be used to wrap long-length contaminated equipment when such equipment is removed from the tanks and prepared for transportation and subsequent disposal or storage. The materials studied were Cooley L18KU, Herculite, and Elephant Mat. The study concludes that these materials are appropriate for use in this application

  8. Shuttle Ku-band bent-pipe implementation considerations. [for Space Shuttle digital communication systems

    Science.gov (United States)

    Batson, B. H.; Seyl, J. W.; Huth, G. K.

    1977-01-01

    This paper describes an approach for relay of data-modulated subcarriers from Shuttle payloads through the Shuttle Ku-band communications subsystem (and subsequently through a tracking and data relay satellite system to a ground terminal). The novelty is that a channel originally provided for baseband digital data is shown to be suitable for this purpose; the resulting transmission scheme is referred to as a narrowband bent-pipe scheme. Test results demonstrating the validity of the narrowband bent-pipe mode are presented, and limitations on system performance are described.

  9. Analysis of Standards Efficiency in Digital Television Via Satellite at Ku and Ka Bands

    Directory of Open Access Journals (Sweden)

    Landeros-Ayala Salvador

    2013-06-01

    Full Text Available In this paper, an analysis on the main technical features of digital television standards for satellite transmission is carried out. Based on simulations and link budgets, the standard with the best operational performance is defined, based on simulations and link budget analysis, as well as a comparative efficiency analysis is conducted for the Ku and Ka bands for both transparent and regenerative transponders in terms of power, bandwidth, information rate and link margin, including clear sky, uplink rain, downlink rain and rain in both.

  10. Absence of hemolytic disease of fetus and newborn despite maternal high-titer IgG anti-Ku.

    Science.gov (United States)

    Kakaiya, R M; Whaley, A; Howard-Menk, C; Rami, J; Papari, M; Campbell-Lee, S; Malecki, Z

    2010-01-01

    Anti-Ku seen in K(o) (Kell-null) individuals has previously been shown to cause severe hemolytic transfusion reactions. Maternal anti-Ku can cause none or moderate to severe hemolytic disease of the fetus and newborn (HDFN). In two of four previously described HDFN cases, intrauterine transfusions were required because of severe anemia. We report a case in which maternal anti-Ku did not cause HDFN. Standard serologic methods were used for RBC antibody screening and identification, adsorption and elution of RBC antibodies, and antigen typing. A gravida 3, para 3 (G3P3) woman was first evaluated in 2006 and was found to have an IgG RBC antibody that reacted against all panel RBCs in the anti-human globulin phase. A panel of RBCs treated with DTT did not react with the antibody. The antibody failed to react with one example of K(o) RBCs. The patient’s RBCs typed negative for the following Kell blood group antigens: KEL1, KEL2, KEL3, KEL4, KEL6, KEL7, KEL11, KEL13, and KEL18. These results established the presence of anti-Ku in maternal serum. The newborn was group A, D+ and required phototherapy for hyperbilirubinemia, but did not require transfusion. The woman was seen again in January 2010 during the third trimester (G4P3). At this time, anti-Ku titer was 256. She delivered a healthy group O, D+ baby boy at 37 weeks' gestation. Cord RBCs were 4+ for IgG by DAT. An eluate reacted with all RBCs tested, but did not react when tested against a panel of DTT-treated RBCs. K(o) phenotype is rare to begin with, and the maternal anti-Ku formation may require more than one pregnancy. Therefore, cases that can be evaluated for anti-Ku–related HDFN are rare. Our case contributes to serologic and clinical aspects of such rare cases.

  11. Analysis of a Compact Wideband Slotted Antenna for Ku Band Applications

    Directory of Open Access Journals (Sweden)

    M. R. Ahsan

    2014-01-01

    Full Text Available The design procedure and physical module of a compact wideband patch antenna for Ku band application are presented in this paper. Finite element method based on 3D electromagnetic field solver has been utilized for the designing and analyzing process of proposed microstrip line fed modified E-H shaped electrically small patch antenna. After successful completion of the design process through various simulations, the proposed antenna has been fabricated on printed circuit board (PCB and its characteristics have been studied. The parameters of the proposed antenna prototype have been measured in standard far-field rectangular shape anechoic measurement compartment. It is apparent from the measured antenna parameters that the proposed antenna achieved almost stable variation of radiation pattern over the entire operational band with 1380 MHz of -10 dB return loss bandwidth. The maximum gain of 7.8 dBi and 89.97% average efficiency within the operating band from 17.15 GHz to 18.53 GHz ensure the suitability of the proposed antenna for Ku band applications.

  12. Oil Slick Observation at Low Incidence Angles in Ku-Band

    Science.gov (United States)

    Panfilova, M. A.; Karaev, V. Y.; Guo, Jie

    2018-03-01

    On the 20 April 2010 the oil platform Deep Water Horizon in the Gulf of Mexico suffered an explosion during the final phases of drilling an exploratory well. As a result, an oil film covered the sea surface area of several thousand square kilometers. In the present paper the data of the Ku-band Precipitation Radar, which operates at low incidence angles, were used to explore the oil spill event. The two-scale model of the scattering surface was used to describe radar backscatter from the sea surface. The algorithm for retrieval of normalized radar cross section at nadir and the total slope variance of large-scale waves compared to the wavelength of electromagnetic wave (22 mm) was developed for the Precipitation Radar swath. It is shown that measurements at low incidence angles can be used for oil spill detection. This is the first time that the dependence of mean square slope of large-scale waves on wind speed has been obtained for oil slicks from Ku-band data, and compared to mean square slope obtained by Cox and Munk from optical data.

  13. 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair

    International Nuclear Information System (INIS)

    Liu, Hongbing; Herrmann, Christine H.; Chiang, Karen; Sung, Tzu-Ling; Moon, Sung-Hwan; Donehower, Lawrence A.; Rice, Andrew P.

    2010-01-01

    Positive elongation factor b (P-TEFb) is a cellular protein kinase that is required for RNA polymerase II (RNAP II) transcriptional elongation of protein coding genes. P-TEFb is a set of different molecular complexes, each containing CDK9 as the catalytic subunit. There are two isoforms of the CDK9 protein - the major 42 KDa CDK9 isoform and the minor 55KDa isoform that is translated from an in-frame mRNA that arises from an upstream transcriptional start site. We found that shRNA depletion of the 55K CDK9 protein in HeLa cells induces apoptosis and double-strand DNA breaks (DSBs). The levels of apoptosis and DSBs induced by the depletion were reduced by expression of a 55K CDK9 protein variant resistant to the shRNA, indicating that these phenotypes are the consequence of depletion of the 55K protein and not off-target effects. We also found that the 55K CDK9 protein, but not the 42K CDK9 protein, specifically associates with Ku70, a protein involved in DSB repair. Our findings suggest that the 55K CDK9 protein may function in repair of DNA through an association with Ku70.

  14. Ku-band electromagnetic wave absorbing properties of polysiloxane derived Si-O-C bulk ceramics

    Science.gov (United States)

    Ding, Donghai; Li, Zipei; Xiao, Guoqing; Yang, Shaoyu

    2018-02-01

    The bulk Si-O-C ceramics were prepared by polymer derived ceramics (PDCs) route using polysiloxane as precursor and their properties were investigated for electromagnetic wave absorbing in the frequency range of 12.4-18 GHz (Ku-band). It was found that the catalytic pyrolysis can enhance substantially the absorbing properties by in situ formation of turbostratic carbon network, ordered carbon, and multi-wall carbon nanotubes. The matching thickness of sample containing 1.5 wt% FeCl3 (FPSO-1.5) is 2.2 mm, and its reflection loss exceeds -10 dB in the whole Ku-band with an absorption peak of -35.48 dB at 14.16 GHz. For sample containing 1.5 wt% FeCl3, its absorption peak increases to -15.78 dB, but its matching thickness decreases significantly to 2.2 mm. The polymer derived Si-O-C ceramics could be used as excellent electromagnetic functional devices working in harsh environments.

  15. A novel coaxial Ku-band transit radiation oscillator without external guiding magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu, E-mail: lingjunpu@163.com; Zhang, Jiande; He, Juntao; Jiang, Tao [College of Photoelectric Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-02-15

    A novel coaxial transit radiation oscillator without external guiding magnetic field is designed to generate high power microwave at Ku-band. By using a coaxial structure, the space-charge potential energy is suppressed significantly, that is good for enhancing efficient beam-wave interaction. In order to improve the transmission stability of the unmagnetized intense relativistic electron beam, a Pierce-like cathode is employed in the novel device. By contrast with conventional relativistic microwave generators, this kind of device has the advantages of high stability, non-guiding magnetic field, and high efficiency. Moreover, with the coaxial design, it is possible to improve the power-handing capacity by increasing the radial dimension of the Ku-band device. With a 550 keV and 7.5 kA electron beam, a 1.25 GW microwave pulse at 12.08 GHz has been obtained in the simulation. The power conversion efficiency is about 30%.

  16. The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression

    Science.gov (United States)

    Sucharov, Carmen C.; Helmke, Steve M.; Langer, Stephen J.; Perryman, M. Benjamin; Bristow, Michael; Leinwand, Leslie

    2004-01-01

    Human heart failure is accompanied by repression of genes such as α myosin heavy chain (αMyHC) and SERCA2A and the induction of fetal genes such as βMyHC and atrial natriuretic factor. It seems likely that changes in MyHC isoforms contribute to the poor contractility seen in heart failure, because small changes in isoform composition can have a major effect on the contractility of cardiac myocytes and the heart. Our laboratory has recently shown that YY1 protein levels are increased in human heart failure and that YY1 represses the activity of the human αMyHC promoter. We have now identified a region of the αMyHC promoter that binds a factor whose expression is increased sixfold in failing human hearts. Through peptide mass spectrometry, we identified this binding activity to be a heterodimer of Ku70 and Ku80. Expression of Ku represses the human αMyHC promoter in neonatal rat ventricular myocytes. Moreover, overexpression of Ku70/80 decreases αMyHC mRNA expression and increases skeletal α-actin. Interestingly, YY1 interacts with Ku70 and Ku80 in HeLa cells. Together, YY1, Ku70, and Ku80 repress the αMyHC promoter to an extent that is greater than that with YY1 or Ku70/80 alone. Our results suggest that Ku is an important factor in the repression of the human αMyHC promoter during heart failure. PMID:15367688

  17. Vecāku un bērnu mantiskās attiecības

    OpenAIRE

    Krauja, Uldis

    2009-01-01

    Bakalaura darba "Vecāku un bērna mantiskās attiecības" mērķis ir izpētīt vecāku un bērna mantisko attiecību regulējumu Latvijas Republikas normatīvajos tiesību aktos, atklājot tajos iespējamās problēmas un nepilnības. Bakalaura darba pirmajā daļā apskatīts vecāku un bērna mantisko attiecību jēdziens un izpratne, pievērsta uzmanība uz vecāku un bērna mantisko attiecību pirmsākumiem caur vēstures prizmu, lai apzinātos ģimenes tiesību nozīmīgumu cilvēces attīstībā un tagadējā dzīvē. Bakalaura da...

  18. Investigation on the performance of an optically generated RF local oscillator signal in Ku-band DVB-S systems

    NARCIS (Netherlands)

    Khan, M.R.H.; Marpaung, D.A.I.; Burla, M.; Roeloffzen, C.G.H.; Bernhardi, Edward; de Ridder, R.M.

    2011-01-01

    We investigate a way to externally generate the local oscillator (LO) signal used for downconversion of the Ku-band (10.7 − 12.75 GHz) RF signal received from a phased array antenna (PAA). The signal is then translated to an intermediate frequency (950 − 2150 MHz) at the output of the mixer of

  19. Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair.

    Science.gov (United States)

    Sinha, Krishna Murari; Stephanou, Nicolas C; Gao, Feng; Glickman, Michael S; Shuman, Stewart

    2007-05-18

    Mycobacterium tuberculosis and other bacterial pathogens have a Ku-dependent nonhomologous end joining pathway of DNA double-strand break repair. Here we identify mycobacterial UvrD1 as a novel interaction partner for Ku in a genome-wide yeast two-hybrid screen. UvrD1 per se is a vigorous DNA-dependent ATPase but a feeble DNA helicase. Ku stimulates UvrD1 to catalyze ATP-dependent unwinding of 3'-tailed DNAs. UvrD1, Ku, and DNA form a stable ternary complex in the absence of ATP. The Ku binding determinants are located in the distinctive C-terminal segment of UvrD1. A second mycobacterial paralog, UvrD2, is a vigorous Ku-independent DNA helicase. Ablation of UvrD1 sensitizes Mycobacterium smegmatis to killing by ultraviolet and ionizing radiation and to a single chromosomal break generated by I-SceI endonuclease. The physical and functional interactions of bacterial Ku and UvrD1 highlight the potential for cross-talk between components of nonhomologous end joining and nucleotide excision repair pathways.

  20. Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions

    International Nuclear Information System (INIS)

    Toyooka, Tatsushi; Ibuki, Yuko; Koike, Manabu; Ohashi, Norio; Takahashi, Sentaro; Goto, Rensuke

    2004-01-01

    Benzo[a]pyrene (BaP) is a ubiquitous environmental pollutant with potential carcinogenicity. It has been shown that BaP, upon UVA irradiation, synergistically induced oxidative DNA damage, but other DNA damage was not confirmed. In this study, we examined whether coexposure to BaP plus UVA induces double strand breaks (DSBs) using xrs-5 cells, deficient in the repair of DSBs (Ku80 mutant), and whether Ku translocates involving the formation of DSBs. BaP plus UVA had a significant cytotoxic effect on CHO-K1 cells and an even more drastic effect on Ku80-deficient, xrs-5 cells, suggesting that the DSBs were generated by coexposure to BaP plus UVA. The DSBs were repaired in CHO-K1 cells within 30 min, but not in xrs-5 cells, indicating the involvement of a non-homologous end joining, which needs Ku proteins. Furthermore, we succeeded in visualizing that Ku80 rapidly assembled to the exposed region, in which DSBs might be generated, and clarified that the presence of both Ku70 and Ku80 was important for their accumulation

  1. Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

    Directory of Open Access Journals (Sweden)

    Eun Young Yu

    2015-10-01

    Full Text Available A subset of human cancer cells uses a specialized, aberrant recombination pathway known as ALT to maintain telomeres, which in these cells are characterized by complex aberrations including length heterogeneity, high levels of unpaired C-strand, and accumulation of extra-chromosomal telomere repeats (ECTR. These phenotypes have not been recapitulated in any standard budding or fission yeast mutant. We found that eliminating Ku70 or Ku80 in the yeast-like fungus Ustilago maydis results initially in all the characteristic telomere aberrations of ALT cancer cells, including C-circles, a highly specific marker of ALT. Subsequently the ku mutants experience permanent G2 cell cycle arrest, accompanied by loss of telomere repeats from chromosome ends and even more drastic accumulation of very short ECTRs (vsECTRs. The deletion of atr1 or chk1 rescued the lethality of the ku mutant, and "trapped" the telomere aberrations in the early ALT-like stage. Telomere abnormalities are telomerase-independent, but dramatically suppressed by deletion of mre11 or blm, suggesting major roles for these factors in the induction of the ALT pathway. In contrast, removal of other DNA damage response and repair factors such as Rad51 has disparate effects on the ALT phenotypes, suggesting that these factors process ALT intermediates or products. Notably, the antagonism of Ku and Mre11 in the induction of ALT is reminiscent of their roles in DSB resection, in which Blm is also known to play a key role. We suggest that an aberrant resection reaction may constitute an early trigger for ALT telomeres, and that the outcomes of ALT are distinct from DSB because of the unique telomere nucleoprotein structure.

  2. A technical writing programme implemented in a first-year engineering course at KU Leuven

    Science.gov (United States)

    Heylen, Christel; Vander Sloten, Jos

    2013-12-01

    Technical communication and technical writing are important skills for the daily work-life of every engineer. In the first-year engineering programme at KU Leuven, a technical writing programme is implemented within the project-based course 'Problem Solving and Engineering Design'. This paper describes a case study for implementing a writing programme based on active learning methods and situated learning in large classes. The programme consists of subsequent cycles of instructions, learning by doing and reflection on received feedback. In addition, a peer-review assignment, together with an interactive lecture using clicking devices, is incorporated within the assignments of the second semester. A checklist of desired writing abilities makes it easier to grade the large number of papers. Furthermore, this ensures that all staff involved in the evaluation process uses the same criteria to grade and for providing feedback.

  3. Low-loss negative index metamaterials for X, Ku, and K microwave bands

    Directory of Open Access Journals (Sweden)

    David A. Lee

    2015-04-01

    Full Text Available Low-loss, negative-index of refraction metamaterials were designed and tested for X, Ku, and K microwave frequency bands. An S-shaped, split-ring resonator was used as a unit cell to design homogeneous slabs of negative-index metamaterials. Then, the slabs of metamaterials were cut unto prisms to measure experimentally the negative index of refraction of a plane electromagnetic wave. Theoretical simulations using High-Frequency Structural Simulator, a finite element equation solver, were in good agreement with experimental measurements. The negative index of refraction was retrieved from the angle- and frequency-dependence of the transmitted intensity of the microwave beam through the metamaterial prism and compared well to simulations; in addition, near-field electromagnetic intensity mapping was conducted with an infrared camera, and there was also a good match with the simulations for expected frequency ranges for the negative index of refraction.

  4. Wideband Array for C, X, and Ku-Band Applications with 5.3:1 Bandwidth

    Science.gov (United States)

    Novak, Markus H.; Volakis, John L.; Miranda, Felix A.

    2015-01-01

    Planar arrays that exploit strong intentional coupling between elements have allowed for very wide bandwidths in low-profile configurations. However, such designs also require complex impedance matching networks that must also be very compact. For many space applications, typically occurring at C-, X-, Ku-, and most recently at Ka-band, such designs require specialized and expensive fabrication techniques. To address this issue, a novel ultra-wideband array is presented, using a simplified feed network to reduce fabrication cost. The array operates from 3.5-18.5 GHz with VSWR less than 2.4 at broadside, and is of very low profile, having a total height of lambda/10 at the lowest frequency of operation. Validation is provided using a 64-element prototype array, fabricated using common Printed Circuit Board (PCB) technology. The low size, weight, and cost of this array make it attractive for space-borne applications.

  5. STS-79 Ku-band antenna, ODS and Spacehab module at PCR

    Science.gov (United States)

    1996-01-01

    The orbiter Ku-band antenna looms large in this view of the Space Shuttle Atlantis' payload bay. Visible just past the antenna system -- stowed on the starboard side of the payload bay wall -- is the Orbiter Docking System (ODS), and connected to the ODS via a tunnel is the Spacehab Double Module in the aft area of the payload bay. This photograph was taken from the starboard wing platform on the fifth level of the Payload Changeout Room (PCR) at Launch Pad 39A. Work is under way in the PCR to close Atlantis' payload bay doors for flight. Atlantis currently is being targeted for liftoff on Mission STS-79, the fourth docking of the U.S. Shuttle to the Russian Space Station Mir, around September 12.

  6. A wideband superconducting filter at Ku-band based on interdigital coupling

    Science.gov (United States)

    Jiang, Ying; Wei, Bin; Cao, Bisong; Li, Qirong; Guo, Xubo; Jiang, Linan; Song, Xiaoke; Wang, Xiang

    2018-04-01

    In this paper, an interdigital-type resonator with strong electric coupling is proposed for the wideband high-frequency (>10 GHz) filter design. The proposed microstrip resonator consists of an H-shaped main line part with its both ends installed with interdigital finger parts. Strong electric coupling is achieved between adjacent resonators. A six-pole high-temperature superconducting filter at Ku-band using this resonator is designed and fabricated. The filter has a center frequency of 15.11 GHz with a fractional bandwidth of 30%. The insertion loss of the passband is less than 0.3 dB, and the return loss is greater than 14 dB without any tuning.

  7. The pretreatment of corn stover with Gloeophyllum trabeum KU-41 for enzymatic hydrolysis

    Directory of Open Access Journals (Sweden)

    Gao Ziqing

    2012-05-01

    Full Text Available Abstract Background Pretreatment is an essential step in the enzymatic hydrolysis of biomass for bio-ethanol production. The dominant concern in this step is how to decrease the high cost of pretreatment while achieving a high sugar yield. Fungal pretreatment of biomass was previously reported to be effective, with the advantage of having a low energy requirement and requiring no application of additional chemicals. In this work, Gloeophyllum trabeum KU-41 was chosen for corn stover pretreatment through screening with 40 strains of wood-rot fungi. The objective of the current work is to find out which characteristics of corn stover pretreated with G. trabeum KU-41 determine the pretreatment method to be successful and worthwhile to apply. This will be done by determining the lignin content, structural carbohydrate, cellulose crystallinity, initial adsorption capacity of cellulase and specific surface area of pretreated corn stover. Results The content of xylan in pretreated corn stover was decreased by 43% in comparison to the untreated corn stover. The initial cellulase adsorption capacity and the specific surface area of corn stover pretreated with G. trabeum were increased by 7.0- and 2.5-fold, respectively. Also there was little increase in the cellulose crystallinity of pretreated corn stover. Conclusion G. trabeum has an efficient degradation system, and the results indicated that the conversion of cellulose to glucose increases as the accessibility of cellulose increases due to the partial removal of xylan and the structure breakage of the cell wall. This pretreatment method can be further explored as an alternative to the thermochemical pretreatment method.

  8. Enterocin X, a Novel Two-Peptide Bacteriocin from Enterococcus faecium KU-B5, Has an Antibacterial Spectrum Entirely Different from Those of Its Component Peptides▿

    Science.gov (United States)

    Hu, Chih-Bo; Malaphan, Wanna; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji

    2010-01-01

    Enterocin X, composed of two antibacterial peptides (Xα and Xβ), is a novel class IIb bacteriocin from Enterococcus faecium KU-B5. When combined, Xα and Xβ display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. In E. faecium strains that produce enterocins A and B, such as KU-B5, only one additional bacteriocin had previously been known. PMID:20418437

  9. Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides.

    Science.gov (United States)

    Hu, Chih-Bo; Malaphan, Wanna; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji

    2010-07-01

    Enterocin X, composed of two antibacterial peptides (Xalpha and Xbeta), is a novel class IIb bacteriocin from Enterococcus faecium KU-B5. When combined, Xalpha and Xbeta display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. In E. faecium strains that produce enterocins A and B, such as KU-B5, only one additional bacteriocin had previously been known.

  10. DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

    Science.gov (United States)

    Radhakrishnan, Sarvan Kumar; Lees-Miller, Susan P

    2017-09-01

    Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks (DSBs) in human cells. Critical to NHEJ is the DNA-dependent interaction of the Ku70/80 heterodimer with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the DNA-PK holoenzyme. However, precisely how Ku recruits DNA-PKcs to DSBs ends to enhance its kinase activity has remained enigmatic, with contradictory findings reported in the literature. Here we address the role of the Ku80 C-terminal region (CTR) in the DNA-dependent interaction of Ku70/80 with DNA-PKcs using purified components and defined DNA structures. Our results show that the Ku80 CTR is required for interaction with DNA-PKcs on short segments of blunt ended 25bp dsDNA or 25bp dsDNA with a 15-base poly dA single stranded (ss) DNA extension, but this requirement is less stringent on longer dsDNA molecules (35bp blunt ended dsDNA) or 25bp duplex DNA with either a 15-base poly dT or poly dC ssDNA extension. Moreover, the DNA-PKcs-Ku complex preferentially forms on 25 bp DNA with a poly-pyrimidine ssDNA extension.Our work clarifies the role of the Ku80 CTR and dsDNA ends on the interaction of DNA-PKcs with Ku and provides key information to guide assembly and biology of NHEJ complexes. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. EPR study of gamma and neutron irradiation effects on KU1, KS-4V and Infrasil 301 silica glasses

    International Nuclear Information System (INIS)

    Lagomacini, Juan C.; Bravo, David; Leon, Monica; Martin, Piedad; Ibarra, Angel; Martin, Agustin; Lopez, Fernando J.

    2011-01-01

    Electron paramagnetic resonance (EPR) studies have been carried out on KU1 and KS-4V high purity quartz glasses and commercial silica Infrasil 301, irradiated with gamma rays up to a dose of 11.6 MGy and neutron fluences of 10 21 and 10 22 n/m 2 . Gamma irradiations produce a much higher concentration of defect centres (mainly E', POR and NBOHC) for KU1 and I301 than for KS-4V silica. In contrast, neutron irradiation at the highest fluence produces similar concentrations in all silica types. These results agree to a good extent with those obtained in previous optical absorption measurements. Moreover, oxygen-related centres (POR and NBOHC) have been well characterized by means of electron paramagnetic resonance.

  12. EPR study of gamma and neutron irradiation effects on KU1, KS-4V and Infrasil 301 silica glasses

    Energy Technology Data Exchange (ETDEWEB)

    Lagomacini, Juan C., E-mail: jc.lagomacini@uam.es [Dept. Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Bravo, David [Dept. Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Leon, Monica; Martin, Piedad; Ibarra, Angel [Materiales para Fusion, CIEMAT, Avda. Complutense 22, E-28040 Madrid (Spain); Martin, Agustin [Dept. Fisica e Instalaciones, ETS Arquitectura UPM, E-28040 Madrid (Spain); Lopez, Fernando J. [Dept. Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain)

    2011-10-01

    Electron paramagnetic resonance (EPR) studies have been carried out on KU1 and KS-4V high purity quartz glasses and commercial silica Infrasil 301, irradiated with gamma rays up to a dose of 11.6 MGy and neutron fluences of 10{sup 21} and 10{sup 22} n/m{sup 2}. Gamma irradiations produce a much higher concentration of defect centres (mainly E', POR and NBOHC) for KU1 and I301 than for KS-4V silica. In contrast, neutron irradiation at the highest fluence produces similar concentrations in all silica types. These results agree to a good extent with those obtained in previous optical absorption measurements. Moreover, oxygen-related centres (POR and NBOHC) have been well characterized by means of electron paramagnetic resonance.

  13. Experimental demonstration of a Ku-band radial-line relativistic klystron oscillator based on transition radiation

    Science.gov (United States)

    Dang, Fangchao; Zhang, Xiaoping; Zhang, Jun; Ju, Jinchuan; Zhong, Huihuang

    2017-03-01

    We report on a radial-line relativistic klystron oscillator (RL-RKO), which is physically designed to generate gigawatt-level high power microwaves (HPMs) at Ku-band. The 3π/4 mode of a four-gap buncher is selected to highly modulate the radially propagating intense relativistic electron beam (IREB). A three-gap extractor operating at the π mode is employed to extract the radio-frequency energy efficiently. The Ku-band RL-RKO is investigated experimentally on an intense-current electron beam accelerator. The radially propagating IREB is well focused with an axial-width of 2 mm by a radial magnetic field of 0.4 T. Microwaves with a frequency of 14.86 GHz and a power of 1.5 GW are generated, corresponding to an efficiency of 24%, which indicates a significant advance for the research of radial-line HPM sources.

  14. Suppression of the asymmetric competition mode in the relativistic Ku-band coaxial transit-time oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu; He, Juntao; Zhang, Jiande; Jiang, Tao; Wang, Lei [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-10-15

    A relativistic Ku-band coaxial transit-time oscillator has been proposed in our previous work. In the experiments, we find that the asymmetric competition mode in the device limits the microwave power with the increase of the input electric power. For solving such a problem, the methods for analysis and suppression of the asymmetric competition mode in the device are investigated theoretically and experimentally. It is shown that the structure and the material of the collector, the concentricity, and the electron emission uniformity play an important part in the suppression of the asymmetric competition mode in the relativistic Ku-band transit-time oscillator. In the subsequent experiments, the asymmetric mode was suppressed effectively. At a low guiding magnetic field of 0.7 T, a microwave pulse with power of 1 GW, frequency of 14.3 GHz close to the simulation one, and efficiency of 20% was generated.

  15. Oxygen Isotope Records in Modern Oyster Shells from Chi Ku, Tainan and Their Implication of Seasonality

    Science.gov (United States)

    Chen, Y. C.; Mii, H. S.; Li, K. T.

    2015-12-01

    To exam whether oxygen isotope records of Crassostrea gigasoysters can be used as proxies of environment, 133 cultivated oysters and 21 water samples were collected from Chi Ku area, Tainan City, southern Taiwan in December of 2012, and from March, 2013 to July, 2014. Instrumental air and water temperatures and precipitation records were obtained from a nearest Central Weather Bureau (CWB) station roughly 16 km north of Chi Ku. The oxygen and carbon isotope values of the ligamental area of the modern oyster shells are from -6.92‰ to -0.08‰ (-3.05 ± 1.17‰, N = 2280; 1σ; VPDB) and from -5.57‰ to 0.63‰ (-1.88 ± 0.81‰), respectively. Oxygen isotope values of the water samples are mainly between -0.28‰ and 0.74‰ (0.18 ± 0.29‰, N = 20; 1σ; VSMOW). However, water oxygen isotope value of -2.75‰ was observed for the water sample collected immediately after a typhoon heavy rainfall. Seasonal temperature fluctuation pattern of estimated oxygen isotope temperatures from modern shells is similar to that of CWB instrumental records. However, the oxygen isotope temperatures are respectively about 3 °C and 10°C higher than those of instrumental records for winter and summer. Higher estimated oxygen isotope temperatures are most likely caused by underestimated fraction of freshwater. We analyzed 5 archaeological oyster shells of Siraya culture (500~250B.P.) collected from Wu Chien Tuso North (WCTN) archaeological site of Tainan branch of Southern Taiwan Science Park to infer the harvest season of mollusks. Oxygen isotope values of the ligamental area of the archaeological oyster shells are between -5.98‰ and -1.26‰ (-3.34 ± 1.37‰, N = 60; 1σ), and carbon isotope values are between -3.21‰ and 0.60‰ (-2.04‰ ± 0.55‰). The oxygen isotope records of archaeological oyster shells also showed clear seasonality. Most of the oysters were collected in autumn and winter. Oxygen isotope values of archaeological oyster shells was 1‰ greater than that

  16. [Professor Wacław Kuśnierczyk (1908-1997)--Pro Memoria in the century of birthday].

    Science.gov (United States)

    Brozek, Krzysztof; Kozakiewicz, Jacek; Kierzek, Andrzej

    2009-01-01

    Wacław Kuśnierczyk was born in 1908 in Sniatyń. He received the degree in medicine at Jan Kazimierz University in Lwów in 1932. He did his PhD degree under Professor Zaleski supervision in 1938 at Jan Kazimierz University. At that time he concentrated his scientific activity on research on tuberculosis. In 1953 he obtained the title of second degree specialist in ear, nose and throat diseases. He became a chief of Otolaryngology at Urban Hospital No 4 in Katowice in 1960. Since then this eminent physician was working on tumours located in upper respiratory tract and the possibility of its endoscopic diagnosis at Silesian Academy of Medicine in Katowice. As one of the first he pointed out the negative influence of smoking cigarettes on cancer of larynx. It was Wacław Kuśnierczyk who implemented new priorities for integrated programs in patient care, research, education and cancer prevention. He has published widely in peer reviewed journals and has edited or contributed to many books. He has given many major lectures and is the recipient of numerous prestigious awards for his scientific accomplishments. The achievement of Professor Kuśnierczyk were the valuable source of information for the physicians. In 1997, on the 31st of January he died in Katowice.

  17. PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

    Directory of Open Access Journals (Sweden)

    Satish K. Tadi

    2016-10-01

    Full Text Available In mammalian cells, classical non-homologous end joining (c-NHEJ is critical for DNA double-strand break repair induced by ionizing radiation and during V(DJ recombination in developing B and T lymphocytes. Recently, PAXX was identified as a c-NHEJ core component. We report here that PAXX-deficient cells exhibit a cellular phenotype uncharacteristic of a deficiency in c-NHEJ core components. PAXX-deficient cells display normal sensitivity to radiomimetic drugs, are proficient in transient V(DJ recombination assays, and do not shift toward higher micro-homology usage in plasmid repair assays. Although PAXX-deficient cells lack c-NHEJ phenotypes, PAXX forms a stable ternary complex with Ku bound to DNA. Formation of this complex involves an interaction with Ku70 and requires a bare DNA extension for stability. Moreover, the relatively weak Ku-dependent stimulation of LIG4/XRCC4 activity by PAXX is unmasked by XLF ablation. Thus, PAXX plays an accessory role during c-NHEJ that is largely overlapped by XLF’s function.

  18. A Small Ku-Band Polarization Tracking Active Phased Array for Mobile Satellite Communications

    Directory of Open Access Journals (Sweden)

    Wei Shi

    2013-01-01

    Full Text Available A compact polarization tracking active phased array for Ku-band mobile satellite signal reception is presented. In contrast with conventional mechanically tracking antennas, the approach presented here meets the requirements of beam tracking and polarization tracking simultaneously without any servo components. The two-layer stacked square patch fed by two probes is used as antenna element. The impedance bandwidth of 16% for the element covers the operating frequency range from 12.25 GHz to 12.75 GHz. In the presence of mutual coupling, the dimensional parameters for each element of the small 7 × 7 array are optimized during beam scanning and polarization tracking. The compact polarization tracking modules based on the low-temperature cofired ceramic (LTCC system-in-package (SiP technology are proposed. A small active phased array prototype with the size of 120 mm (length × 120 mm (width × 55 mm (height is developed. The measured polarization tracking patterns of the prototype are given. The polarization tracking beam can be steered in the elevation up to 50°. The gain of no less than 16.0 dBi and the aperture efficiency of more than 50% are obtained. The measured and simulated polarization tracking patterns agreed well.

  19. Analysis and comparison model for measuring tropospheric scintillation intensity for Ku-band frequency in Malaysia

    Directory of Open Access Journals (Sweden)

    Mandeep JS

    2011-06-01

    Full Text Available This study has been based on understanding local propagation signal data distribution characteristics and identifying and predicting the overall impact of significant attenuating factors regarding the propagation path such as impaired propagation for a signal being transmitted. Predicting propagation impairment is important for accurate link budgeting, thereby leading to better communication network system designation. This study has thus used sample data for one year concerning beacon satellite operation in Malaysia from April 2008 to April 2009. Data concerning 12GHz frequency (Ku-band and 40° elevation angle was collected and analysed, obtaining average signal amplitude value, ÷ and also standard deviation ó which is normally measured in dB to obtain long-term scintillation intensity distribution. This analysis showed that scintillation intensity distribution followed Gaussian distribution for long-term data distribution. A prediction model was then selected based on the above; Karasawa,
    ITU-R, Van de Kamp and Otung models were compared to obtain the best prediction model performance for selected data regarding specific meteorological conditions. This study showed that the Karasawa model had the best performance for predicting scintillation intensity for the selected da ta.

  20. Extracted atmospheric impairments on earth-sky signal quality in tropical regions at Ku-band

    Science.gov (United States)

    Al-Saegh, Ali Mohammed; Sali, Aduwati; Mandeep, J. S.; Ismail, Alyani

    2013-11-01

    Atmospheric condition variations were shown to have a major effect on the earth sky signal quality at Ku band. Moreover, such variations increased in the tropical regions as compared to temperate areas due to their different weather parameters. With the increase of recent satellite communication technology applications throughout the tropical countries and lack of information regarding the atmospheric impairments analysis, simulation and mitigation techniques, there is an ever increasing need for extracting a unique and accurate performance of the signal quality effects during highly natural tropical weather impairments. This paper presents a new method developed for proper analysis with distinctive and highly realistic performance evaluation for signal quality during the atmospheric conditions variations in 14 tropical areas from the four continents analyzed based on actual measured parameters. The method implementation includes signal attenuation, carrier to noise ratio, symbol energy to noise ratio, and symbol error rate at different areas and different modulation schemes. Furthermore, for improvement in analysis in terms of covering more remarkable regions in tropics, the paper provides new measurements data with analysis for certain region in tropics used as a test bed and to add measurement data of such area to the world's data base for future researchers. The results show a significant investigation and performance observation in terms of weather impairments in tropical regions in general and each region in that area in particular regarding the signal attenuation and error rates accompanied for several transmission schemes.

  1. Design studies of the Ku-band, wide-band Gyro-TWT amplifier

    Science.gov (United States)

    Jung, Sang Wook; Lee, Han Seul; Jang, Kwong Ho; Choi, Jin Joo; Hong, Yong Jun; Shin, Jin Woo; So, Jun Ho; Won, Jong Hyo

    2014-02-01

    This paper reports a Ku-band, wide band Gyrotron-Traveling-wave-tube(Gyro-TWT) that is currently being developed at Kwangwoon University. The Gyro-TWT has a two stage linear tapered interaction circuit to obtain a wide operating bandwidth. The linearly-tapered interaction circuit and nonlinearly-tapered magnetic field gives the Gyro-TWT a wide operating bandwidth. The Gyro-TWT bandwidth is 23%. The 2d-Particle-in-cell(PIC) and MAGIC2d code simulation results are 17.3 dB and 24.34 kW, respectively for the maximum saturated output power. A double anode MIG was simulated with E-Gun code. The results were 0.7 for the transvers to the axial beam velocity ratio (=alpha) and a 2.3% axial velocity spread at 50 kV and 4 A. A magnetic field profile simulation was performed by using the Poisson code to obtain the grazing magnetic field of the entire interaction circuit with Poisson code.

  2. A high efficiency Ku-band radial line relativistic klystron amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Dang, Fangchao; Zhang, Xiaoping, E-mail: zhangxiaoping@nudt.edu.cn; Zhong, Huihuang; Zhang, Jun; Ju, Jinchuan [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2016-07-15

    To achieve the gigawatt-level microwave amplification output at Ku-band, a radial-line relativistic klystron amplifier is proposed and investigated in this paper. Different from the annular electron beam in conventional axial relativistic klystron amplifiers, a radial-radiated electron beam is employed in this proposed klystron. Owing to its radially spreading speciality, the electron density and space charge effect are markedly weakened during the propagation in the radial line drift tube. Additionally, the power capacity, especially in the output cavity, is enhanced significantly because of its large volume, which is profitable for the long pulse operation. Particle-in-cell simulation results demonstrate that a high power microwave with the power of 3 GW and the frequency of 14.25 GHz is generated with a 500 kV, 12 kA electron beam excitation and the 30 kW radio-frequency signal injection. The power conversion efficiency is 50%, and the gain is about 50 dB. Meanwhile, there is insignificant electron beam self-excitation in the proposed structure by the adoption of two transverse electromagnetic reflectors. The relative phase difference between the injected signals and output microwaves keeps stable after the amplifier saturates.

  3. Efficient gene replacements in ku70 disruption strain of Aspergillus chevalieri var. intermedius

    Directory of Open Access Journals (Sweden)

    Qingqing Huang

    2017-01-01

    Full Text Available Aspergillus chevalieri var. intermedius is a dominant filamentous fungal species in Fuzhuan tea and is associated with the quality and health benefits of this tea. The sexual or asexual reproduction of this fungus depends on the osmotic pressure of the tea. Efforts to enhance the beneficial effects of A. chevalieri var. intermedius are hampered by difficulties in disrupting its genes. To address this issue, we identified the A. chevalieri var. intermedius homolog (Acku70 of human Ku70 and generated an Acku70 disruption strain (ΔAcku70, aiming to improve the gene replacement efficiency. ΔAcku70 grew at a slightly lower rate in vitro than the wild-type strain; however, the two strains exhibited similar sensitivity to temperature, osmotic pressure and the effects of ethyl methane sulphonate and H2O2. The replacement efficiency of veA and flbA dramatically increased in ΔAcku70 compared to that in the wild type. The efficiency of flbA replacement increased from 2.6% to 80%, whereas the frequency of veA disruption increased from 15.2% to 83.9% and from 30.8% to 86.8%. Thus, ΔAcku70 is suitable for use as a type strain for large-scale functional genomic analysis of A. chevalieri var. intermedius.

  4. Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining.

    Science.gov (United States)

    Wright, Douglas; DeBeaux, Austin; Shi, Runhua; Doherty, Aidan J; Harrison, Lynn

    2010-09-01

    We previously established an Escherichia coli strain capable of re-circularizing linear plasmid DNA by expressing the Mycobacterium tuberculosis Ku (Mt-Ku) and Mycobacterium tuberculosis ligase D (Mt-LigD) proteins from the E.coli chromosome. Repair was predominately mutagenic due to deletions at the termini. We hypothesized that these deletions could be due to a nuclease activity of Mt-LigD that was previously detected in vitro. Mt-LigD has three domains: an N-terminal polymerase domain (PolDom), a central domain with 3'-phosphoesterase and nuclease activity and a C-terminal ligase domain (LigDom). We generated bacterial strains expressing Mt-Ku and mutant versions of Mt-LigD. Plasmid re-circularization experiments in bacteria showed that the PolDom alone had no re-circularization activity. However, an increase in the total and accurate repair was found when the central domain was deleted. This provides further evidence that this central domain does have nuclease activity that can generate deletions during repair. Deletion of only the PolDom of Mt-LigD resulted in a complete loss of accurate repair and a significant reduction in total repair. This is in agreement with published in vitro work indicating that the PolDom is the major Mt-Ku-binding site. Interestingly, the LigDom alone was able to re-circularize plasmid DNA but only in an Mt-Ku-dependent manner, suggesting a potential second site for Ku-LigD interaction. This work has increased our understanding of the mutagenic repair by Mt-Ku and Mt-LigD and has extended the in vitro biochemical experiments by examining the importance of the Mt-LigD domains during repair in bacteria.

  5. Low density lipoprotein receptor gene Ava II polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

    Directory of Open Access Journals (Sweden)

    Wu Dong-Feng

    2011-02-01

    Full Text Available Abstract Background Several common genetic polymorphisms in the low density lipoprotein receptor (LDL-R gene have associated with modifications of serum total cholesterol (TC and low density lipoprotein cholesterol (LDL-C levels, but the results are not consistent in different populations. Bai Ku Yao is a special subgroup of the Yao minority in China. The present study was undertaken to detect the association of LDL-R gene Ava Ⅱ polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Methods A total of 1024 subjects of Bai Ku Yao and 792 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples. Genotyping of the LDL-R gene Ava Ⅱ polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. Results The levels of serum TC, high density lipoprotein cholesterol (HDL-C, LDL-C, apolipoprotein (Apo A1 and the ratio of ApoA1 to ApoB were lower in Bai Ku Yao than in Han (P - and A+ alleles was 65.5% and 34.5% in Bai Ku Yao, and 80.7% and 19.3% in Han (P -A-, A-A+ and A+A+ genotypes was 42.6%, 45.9% and 11.5% in Bai Ku Yao, and 64.9%, 31.6% and 3.5% in Han (P P 3.20 mmol/L subgroups in Bai Ku Yao (P P P P +A+ genotype had higher serum LDL-C, TC, HDL-C or ApoA1 levels than the subjects with A-A+ and A-A- genotypes. Spearman rank correlation analysis revealed that the levels of LDL-C in Bai Ku Yao and HDL-C in Han were correlated with genotypes (P P Conclusions The association of LDL-R gene Ava Ⅱ polymorphism and serum lipid levels is different between the Bai Ku Yao and Han populations. The discrepancy might partly result from different LDL-R gene Ava Ⅱ polymorphism or LDL-R gene-enviromental interactions.

  6. Effects of Snow/ Soil Interface on Microwave Backscatter of Terrestrial Snowpack at X- and Ku- Band

    Science.gov (United States)

    Kang, D. H.; Tan, S.; Zhu, J.; Gu, W.; Tsang, L.; Kim, E. J.

    2017-12-01

    Recent advances in monitoring and modeling capabilities to support remote sensing of terrestrial snow is encouraging to develop satellite mission concept in monitoring cold-region hydrological processes on global scales. However, it is still challenging to link back the active microwave backscattering signals to physical snowpack parameters. One of the limitations resides in the ignorance of the vegetation and soil conditions beneath the snowpack in the microwave scattering/ emission modeling and the snow water equivalent (SWE) retrieval algorithm. During the SnowEx 2017 winter campaign in Grand Mesa, CO, a particular effort has been made on comprehensive measurements of the underlying vegetation and soil characteristics from the snowpit measurements. Besides conducting standard snow core sampling, we have made additional protocols to record the background information beneath the snowpack. Recent works on active SWE retrieval algorithm using backscatters at X- (9.6 GHz) and Ku- (17.2 GHz) band suggest the significant signals from the background scattering characterization. The background scattering arising from the rough snow/ soil interface and the buried vegetation inside and beneath the snowpack modifies the sensitivity of the total backscatter to SWE. In this paper, we summarize the snow/ soil interface conditions as observed in the SnowEx campaign. We also develop standards for future in-situ snowpit measurements to include regular snow/ soil interface observations to accommodate the interpretation of microwave backscatter both for modeling and observation of microwave signatures. These observations first provide inputs to the microwave scattering models to predict the backscattering contribution from background, which is one of the key factors to be included to improve the SWE retrieval performance.

  7. Rainfall measurement from the opportunistic use of an Earth–space link in the Ku band

    Directory of Open Access Journals (Sweden)

    L. Barthès

    2013-08-01

    Full Text Available The present study deals with the development of a low-cost microwave device devoted to the measurement of average rain rates observed along Earth–satellite links, the latter being characterized by a tropospheric path length of a few kilometres. The ground-based power measurements, which are made using the Ku-band television transmissions from several different geostationary satellites, are based on the principle that the atmospheric attenuation produced by rain encountered along each transmission path can be used to determine the path-averaged rain rate. This kind of device could be very useful in hilly areas where radar data are not available or in urban areas where such devices could be directly placed in homes by using residential TV antenna. The major difficulty encountered with this technique is that of retrieving rainfall characteristics in the presence of many other causes of received signal fluctuation, produced by atmospheric scintillation, variations in atmospheric composition (water vapour concentration, cloud water content or satellite transmission parameters (variations in emitted power, satellite pointing. In order to conduct a feasibility study with such a device, a measurement campaign was carried out over a period of five months close to Paris. The present paper proposes an algorithm based on an artificial neural network, used to identify dry and rainy periods and to model received signal variability resulting from effects not related to rain. When the altitude of the rain layer is taken into account, the rain attenuation can be inverted to obtain the path-averaged rain rate. The rainfall rates obtained from this process are compared with co-located rain gauges and radar measurements taken throughout the full duration of the campaign, and the most significant rainfall events are analysed.

  8. Rainfall measurement from the opportunistic use of an Earth-space link in the Ku band

    Science.gov (United States)

    Barthès, L.; Mallet, C.

    2013-08-01

    The present study deals with the development of a low-cost microwave device devoted to the measurement of average rain rates observed along Earth-satellite links, the latter being characterized by a tropospheric path length of a few kilometres. The ground-based power measurements, which are made using the Ku-band television transmissions from several different geostationary satellites, are based on the principle that the atmospheric attenuation produced by rain encountered along each transmission path can be used to determine the path-averaged rain rate. This kind of device could be very useful in hilly areas where radar data are not available or in urban areas where such devices could be directly placed in homes by using residential TV antenna. The major difficulty encountered with this technique is that of retrieving rainfall characteristics in the presence of many other causes of received signal fluctuation, produced by atmospheric scintillation, variations in atmospheric composition (water vapour concentration, cloud water content) or satellite transmission parameters (variations in emitted power, satellite pointing). In order to conduct a feasibility study with such a device, a measurement campaign was carried out over a period of five months close to Paris. The present paper proposes an algorithm based on an artificial neural network, used to identify dry and rainy periods and to model received signal variability resulting from effects not related to rain. When the altitude of the rain layer is taken into account, the rain attenuation can be inverted to obtain the path-averaged rain rate. The rainfall rates obtained from this process are compared with co-located rain gauges and radar measurements taken throughout the full duration of the campaign, and the most significant rainfall events are analysed.

  9. Estimating Snow Water Equivalent with Backscattering at X and Ku Band Based on Absorption Loss

    Directory of Open Access Journals (Sweden)

    Yurong Cui

    2016-06-01

    Full Text Available Snow water equivalent (SWE is a key parameter in the Earth’s energy budget and water cycle. It has been demonstrated that SWE can be retrieved using active microwave remote sensing from space. This necessitates the development of forward models that are capable of simulating the interactions of microwaves and the snow medium. Several proposed models have described snow as a collection of sphere- or ellipsoid-shaped ice particles embedded in air, while the microstructure of snow is, in reality, more complex. Natural snow usually forms a sintered structure following mechanical and thermal metamorphism processes. In this research, the bi-continuous vector radiative transfer (bi-continuous-VRT model, which firstly constructs snow microstructure more similar to real snow and then simulates the snow backscattering signal, is used as the forward model for SWE estimation. Based on this forward model, a parameterization scheme of snow volume backscattering is proposed. A relationship between snow optical thickness and single scattering albedo at X and Ku bands is established by analyzing the database generated from the bi-continuous-VRT model. A cost function with constraints is used to solve effective albedo and optical thickness, while the absorption part of optical thickness is obtained from these two parameters. SWE is estimated after a correction for physical temperature. The estimated SWE is correlated with the measured SWE with an acceptable accuracy. Validation against two-year measurements, using the SnowScat instrument from the Nordic Snow Radar Experiment (NoSREx, shows that the estimated SWE using the presented algorithm has a root mean square error (RMSE of 16.59 mm for the winter of 2009–2010 and 19.70 mm for the winter of 2010–2011.

  10. Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70–Bax interaction in prostate cancer

    Science.gov (United States)

    Shukla, Sanjeev; Fu, Pingfu; Gupta, Sanjay

    2014-01-01

    Dysfunction of the apoptotic pathway in prostate cancer cells confers apoptosis resistance towards various therapies. A novel strategy to overcome resistance is to directly target the apoptotic pathway in cancer cells. Apigenin, an anticancer agent, selectively toxic to cancer cells induces cell cycle arrest and apoptosis through mechanisms which are not fully explored. In the present study we provide novel insight into the mechanisms of apoptosis induction by apigenin. Treatment of androgen-refractory human prostate cancer PC-3 and DU145 cells with apigenin resulted in dose-dependent suppression of XIAP, c-IAP1, c-IAP2 and survivin protein levels. Apigenin treatment resulted in significant decrease in cell viability and apoptosis induction with the increase of cytochrome C in time-dependent manner. These effects of apigenin were accompanied by decrease in Bcl-xL and Bcl-2 and increase in the active form of Bax protein. The apigenin-mediated increase in Bax was due to dissociation of Bax from Ku70 which is essential for apoptotic activity of Bax. Apigenin treatment resulted in the inhibition of class I histone deacetylases and HDAC1 protein expression, thereby increasing the acetylation of Ku70 and the dissociation of Bax resulting in apoptosis of cancer cells. Furthermore, apigenin significantly reduced HDAC1 occupancy at the XIAP promoter, suggesting that histone deacetylation might be critical for XIAP downregulation. These results suggest that apigenin targets inhibitor of apoptosis proteins and Ku70–Bax interaction in the induction of apoptosis in prostate cancer cells and in athymic nude mouse xenograft model endorsing its in vivo efficacy. PMID:24563225

  11. Evaluation of genetic alteration induced by radon gas using the micronucleus test (Tradescantia sp. clone KU-20)

    International Nuclear Information System (INIS)

    Bruschi, Armando L.; Azevedo, Heliana de; Macacini, Jose F.; Roque, Claudio V.

    2011-01-01

    The first observations over the existence of radon gas (Rn), initially known as 'thorium emanation', were carried out between the end of 19 th and beginning of 20 th centuries. A result of uranium-238 (U 238 ) radioactive decay, radon is a tasteless, odorless and colorless gas under room temperature, with a 3.825-day half life and particle α emission in its decay, and as final product of its disintegration, the stable lead-206 isotope (Pb 206 ). Being it is the gas with the highest density known, closed and poor ventilated environments are favorable to its accumulation, with its inhalation being the highest health risk. The use of vegetal bioindicators has shown to be excellent on the monitoring of air quality and on mutagenic potential of various pollutants contained in the atmosphere. Within this context, the objective of this study was to evaluate the micronucleus test application potential utilizing the Tradescantia sp. clone KU-20, in order to evaluate genetic alterations induced by radon gas. Stems of Tradescantia sp. clone KU-20, previously immerse in Hoagland solution, were introduced in a radon detection equipment's calibration chamber (Alphaguard), containing radium salt. Afterwards, the accommodated stems were exposed to radon gas (the average radon concentration was 7.639 KBq/m3) for 24 hours. The results demonstrated an increase on micronucleus formation (39.23 + 2.143 MCN/100 tetrads) in stems exposed in relation to the negative control (18.00 + 1.396 MCN/100 tetrads). The difference between the values indicated a significant increase on micronucleus frequency in the inflorescences subjected to radon gas. The presented results demonstrated the micronucleus test application potential using Tradescantia clone KU-20 to evaluate genetic effects induced by radon gas. (author)

  12. Study of the Effect of Simulated Rain on the Offset Parabolic Antenna at Ku-Band with Different Elevation Angles

    Directory of Open Access Journals (Sweden)

    H. Mostafa

    2007-01-01

    Full Text Available Effect of rain on the receiver antenna is a major factor to degrade the system performance in a frequency above 10 GHz. This paper deals with the wet antenna attenuation at Ku-band with three different frequencies at different rain rates. During the Ku-band propagation experiment, it was discovered that rain water on the antenna caused a significant attenuation. It is necessary to estimate the losses caused by water on the antenna in order to separate these losses from the atmospheric propagation losses. The experiment was done at USM Engineering Campus to study the attenuation for these physical parameters. A Ku-band RF signal was generated by a signal generator and transmitted via horn antenna. The signal was received using a smooth offset antenna of 60 cm by 54 cm (Astro dish and measured using spectrum analyzer. In order to simulate a rain, pipes with bores of a same distance were implemented. Three cases were considered: in the first case one pipe was used to simulate low rain rate, the second case two pipes were used to simulate medium rain rate, and the third case three pipes were used to simulate heavy rain rate. In addition, the tap was used to control the flow of water in order to get more values of rain rate. The total attenuation of RF signals due to water layer on the feed and on the reflector feed was found to be 3.1 dB at worst case. On the other hand, the attenuation of RF signal due to the feed only was 2.83 dB, so the major attenuation occur was due to feed.

  13. Effects of surface roughness on sea ice freeboard retrieval with an Airborne Ku-Band SAR radar altimeter

    DEFF Research Database (Denmark)

    Hendricks, Stefan; Stenseng, Lars; Helm, Veit

    2010-01-01

    to investigate sea ice volume changes on an Arctic wide scale. Freeboard retrieval requires precise radar range measurements to the ice surface, therefore we investigate the penetration of the Ku-Band radar waves into the overlying snow cover as well as the effects of sub-footprint-scale surface roughness using...... airborne radar and laser altimeters. We find regional variable penetration of the radar signal at late spring conditions, where the difference of the radar and the reference laser range measurement never agrees with the expected snow thickness. In addition, a rough surface can lead to biases...

  14. Pirmsskolas vecuma bērnu vecāku emocionālais intelekts un stresa līmenis saistībā ar vecāku audzināšanas pieejām

    OpenAIRE

    Pastare, Ilze

    2007-01-01

    Rezumējums Pētījuma mērķis bija noskaidrot pirmsskolas vecuma bērnu vecāku emocionālā intelekta un stresa līmeņa rādītāju saistību ar audzināšanas pieejām. Kopā pētījumā piedalījās 41 māte. Vidējais vecums mātēm – 33 gadi, bērnu vidējais vecums – 5 gadi. Pētījumā tika izmantotas šādas metodes: “ Bar-On Emocionālā intelekta aptauja”, “Vecāku stresa indekss”, “ Alabamas audzināšanas aptaujas pirmsskolas versija”. Pētījumā tika noskaidrots, ka pastāv statistiski nozīmīga po...

  15. Differential gene expression in a DNA double-strand-break repair mutant XRS-5 defective in Ku80. Analysis by cDNA microarray

    Energy Technology Data Exchange (ETDEWEB)

    Chan, John Y.H.; Chen, Lung-Kun; Chang, Jui-Feng [National Yang Ming Univ., Taipei, Taiwan (China). Inst. of Radiological Sciences] (and others)

    2001-12-01

    The ability of cells to rejoin DNA double-strand breaks (DSBs) usually correlates with their radiosensitivity. This correlation has been demonstrated in radiosensitive cells, including the Chinese hamster ovary mutant XRS-5. XRS-5 is defective in a DNA end-binding protein, Ku80, which is a component of a DNA-dependent protein kinase complex used for joining strand breaks. However, Ku80-deficient cells are known to be retarded in cell proliferation and growth as well as other yet to be identified defects. Using custom-made 600-gene cDNA microarray filters, we found differential gene expressions between the wild-type and XRS-5 cells. Defective Ku80 apparently affects the expression of several repair genes, including topoisomerase-I and -IIA, ERCC5, MLH1, and ATM. In contrast, other DNA repair-associated genes, such as GADD45A, EGR1 MDM2 and p53, were not affected. In addition, for large numbers of growth-associated genes, such as cyclins and clks, the growth factors and cytokines were also affected. Down-regulated expression was also found in several categories of seemingly unrelated genes, including apoptosis, angiogenesis, kinase and signaling, phosphatase, stress protein, proto-oncogenes and tumor suppressors, transcription and translation factors. A RT-PCR analysis confirmed that the XRS-5 cells used were defective in Ku80 expression. The diversified groups of genes being affected could mean that Ku80, a multi-functional DNA-binding protein, not only affects DNA repair, but is also involved in transcription regulation. Our data, taken together, indicate that there are specific genes being modulated in Ku80- deficient cells, and that some of the DNA repair pathways and other biological functions are apparently linked, suggesting that a defect in one gene could have global effects on many other processes. (author)

  16. Differential gene expression in a DNA double-strand-break repair mutant XRS-5 defective in Ku80. Analysis by cDNA microarray

    International Nuclear Information System (INIS)

    Chan, John Y.H.; Chen, Lung-Kun; Chang, Jui-Feng

    2001-01-01

    The ability of cells to rejoin DNA double-strand breaks (DSBs) usually correlates with their radiosensitivity. This correlation has been demonstrated in radiosensitive cells, including the Chinese hamster ovary mutant XRS-5. XRS-5 is defective in a DNA end-binding protein, Ku80, which is a component of a DNA-dependent protein kinase complex used for joining strand breaks. However, Ku80-deficient cells are known to be retarded in cell proliferation and growth as well as other yet to be identified defects. Using custom-made 600-gene cDNA microarray filters, we found differential gene expressions between the wild-type and XRS-5 cells. Defective Ku80 apparently affects the expression of several repair genes, including topoisomerase-I and -IIA, ERCC5, MLH1, and ATM. In contrast, other DNA repair-associated genes, such as GADD45A, EGR1 MDM2 and p53, were not affected. In addition, for large numbers of growth-associated genes, such as cyclins and clks, the growth factors and cytokines were also affected. Down-regulated expression was also found in several categories of seemingly unrelated genes, including apoptosis, angiogenesis, kinase and signaling, phosphatase, stress protein, proto-oncogenes and tumor suppressors, transcription and translation factors. A RT-PCR analysis confirmed that the XRS-5 cells used were defective in Ku80 expression. The diversified groups of genes being affected could mean that Ku80, a multi-functional DNA-binding protein, not only affects DNA repair, but is also involved in transcription regulation. Our data, taken together, indicate that there are specific genes being modulated in Ku80- deficient cells, and that some of the DNA repair pathways and other biological functions are apparently linked, suggesting that a defect in one gene could have global effects on many other processes. (author)

  17. Synergistic effects of methyl methanesulfonate and X rays in inducing somatic mutations in the stamen hairs of Tradescantia clones, KU 27 and BNL 4430

    International Nuclear Information System (INIS)

    Ichikawa, Sadao; Yamaguchi, Akihiko; Okumura, Mikiko

    1993-01-01

    Young influorescences of Tradescantia clones KU 27 and BNL 4430, the both of which are blue/pink heterozygotes and have been demonstrated to be highly sensitive to alkylating agents, were exposed either to aqueous solutions of methyl methanesulfonate (MMS) for 16 hr alone (at 0.005 to 0.02% for KU 27 and at 0.005% for BNL 4430) or to acute 150 kVp X rays alone (161 to 531 mGy for Ku 27 and 501 to 976 mGy for BNL 4430), or in combinations (134 to 448 mGy for KU 27 and 458 to 865 mGy for BNL 4430 after the 0.005% MMS treatment). The induced somatic pink mutation frequencies per hair-cell division were studied and compared, and clone BNL 4430 was found to be nearly two times more sensitive to MMS than clone KU 27, while the X-ray-induced mutation frequencies in the latter was about 1.5 times higher than those in the former. The lower sensitivity to MMS of clone KU 27 (as compared with BNL 4430) was nevertheless about 5.6 times higher as compared with the responses of clone BNL 02 to MMS reported earlier, proving the high sensitivities of the two clones used in the present study. Clear synergistic effects of MMS and X rays were observed in the both clones, indicating that the mechanisms of inducing mutations are common at least in part between MMS and X rays. (author)

  18. The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons.

    Science.gov (United States)

    Vandersickel, Veerle; Mancini, Monica; Slabbert, Jacobus; Marras, Emanuela; Thierens, Hubert; Perletti, Gianpaolo; Vral, Anne

    2010-04-27

    A better understanding of the underlying mechanisms of DNA repair after low- and high-LET radiations represents a research priority aimed at improving the outcome of clinical radiotherapy. To date however, our knowledge regarding the importance of DNA DSB repair proteins and mechanisms in the response of human cells to high-LET radiation, is far from being complete. We investigated the radiosensitizing effect after interfering with the DNA repair capacity in a human mammary epithelial cell line (MCF10A) by lentiviral-mediated RNA interference (RNAi) of the Ku70 protein, a key-element of the nonhomologous end-joining (NHEJ) pathway. Following irradiation of control and Ku-deficient cell lines with either 6 MV X-rays or p(66)+Be(40) neutrons, cellular radiosensitivity testing was performed using a crystal violet cell proliferation assay. Chromosomal radiosensitivity was evaluated using the micronucleus (MN) assay. RNAi of Ku70 caused downregulation of both the Ku70 and the Ku80 proteins. This downregulation sensitized cells to both X-rays and neutrons. Comparable dose modifying factors (DMFs) for X-rays and neutrons of 1.62 and 1.52 respectively were obtained with the cell proliferation assay, which points to the similar involvement of the Ku heterodimer in the cellular response to both types of radiation beams. After using the MN assay to evaluate chromosomal radiosensitivity, the obtained DMFs for X-ray doses of 2 and 4 Gy were 2.95 and 2.66 respectively. After neutron irradiation, the DMFs for doses of 1 and 2 Gy were 3.36 and 2.82 respectively. The fact that DMFs are in the same range for X-rays and neutrons confirms a similar importance of the NHEJ pathway and the Ku heterodimer for repairing DNA damage induced by both X-rays and p(66)+Be(40) neutrons. Interfering with the NHEJ pathway enhanced the radiosensitivity of human MCF10A cells to low-LET X-rays and high-LET neutrons, pointing to the importance of the Ku heterodimer for repairing damage induced by both

  19. Impact of Surface Soil Moisture Variations on Radar Altimetry Echoes at Ku and Ka Bands in Semi-Arid Areas

    Directory of Open Access Journals (Sweden)

    Christophe Fatras

    2018-04-01

    Full Text Available Radar altimetry provides information on the topography of the Earth surface. It is commonly used for the monitoring not only sea surface height but also ice sheets topography and inland water levels. The radar altimetry backscattering coefficient, which depends on surface roughness and water content, can be related to surface properties such as surface soil moisture content. In this study, the influence of surface soil moisture on the radar altimetry echo and backscattering coefficient is analyzed over semi-arid areas. A semi-empirical model of the soil’s complex dielectric permittivity that takes into account that small-scale roughness and large-scale topography was developed to simulate the radar echoes. It was validated using waveforms acquired at Ku and Ka-bands by ENVISAT RA-2 and SARAL AltiKa respectively over several sites in Mali. Correlation coefficients ranging from 0.66 to 0.94 at Ku-band and from 0.27 to 0.96 at Ka-band were found. The increase in surface soil moisture from 0.02 to 0.4 (i.e., the typical range of variations in semi-arid areas increase the backscattering from 10 to 15 dB between the core of the dry and the maximum of the rainy seasons.

  20. Improved foilless Ku-band transit-time oscillator for generating gigawatt level microwave with low guiding magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu; He, Juntao, E-mail: hejuntao12@163.com; Zhang, Jiande; Jiang, Tao; Hu, Yi [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-09-15

    An improved foilless Ku-band transit-time oscillator with low guiding magnetic field is proposed and investigated in this paper. With a non-uniform buncher and a coaxial TM{sub 02} mode dual-resonant reflector, this improved device can output gigawatt level Ku-band microwave with relatively compact radial dimensions. Besides the above virtue, this novel reflector also has the merits of high TEM reflectance, being more suitable for pre-modulating the electron beam and enhancing the conversion efficiency. Moreover, in order to further increase the conversion efficiency and lower the power saturation time, a depth-tunable coaxial collector and a resonant cavity located before the extractor are employed in our device. Main structure parameters of the device are optimized by particle in cell simulations. The typical simulation result is that, with a 380 kV, 8.2 kA beam guided by a magnetic field of about 0.6 T, 1.15 GW microwave pulse at 14.25 GHz is generated, yielding a conversion efficiency of about 37%.

  1. Impact of tropospheric scintillation in the Ku/K bands on the communications between two LEO satellites in a radio occultation geometry

    DEFF Research Database (Denmark)

    Martini, Enrica; Freni, A.; Facheris, L.

    2006-01-01

    A theoretical analysis of the impact of clear-air tropospheric scintillation on a radio occultation link between two low Earth orbit satellites in K- and Ku-bands is presented, with particular reference to differential approaches for the measure of the total content of water vapor. The troposphere...

  2. Návrh zásobníku na sypký vápenný hydrát

    OpenAIRE

    Perna, Marek

    2009-01-01

    Tato diplomová práce řeší návrh hlubokého zásobníku na sypký vápenný hydrát pro technologická zařízení čistíren odpadních vod. Je zde proveden rozbor volby typu a konstrukce zásobníku, návrh rozměrů a pevnostní výpočet zásobníku. Je zde popsána možnost vzniku klenby při vyprazdňování a její potlačení pomocí aktivních a pasivních prvků napomáhající toku. Popis aktivních a pasivních stavů napjatosti materiálu v zásobníku. This diploma thesis is solving systems design of silo for a powdery li...

  3. Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer.

    Science.gov (United States)

    Nguyen, Huy; Loustaunau, Cristy; Facista, Alexander; Ramsey, Lois; Hassounah, Nadia; Taylor, Hilary; Krouse, Robert; Payne, Claire M; Tsikitis, V Liana; Goldschmid, Steve; Banerjee, Bhaskar; Perini, Rafael F; Bernstein, Carol

    2010-07-28

    In carcinogenesis, the "field defect" is recognized clinically because of the high propensity of survivors of certain cancers to develop other malignancies of the same tissue type, often in a nearby location. Such field defects have been indicated in colon cancer. The molecular abnormalities that are responsible for a field defect in the colon should be detectable at high frequency in the histologically normal tissue surrounding a colonic adenocarcinoma or surrounding an adenoma with advanced neoplasia (well on the way to a colon cancer), but at low frequency in the colonic mucosa from patients without colonic neoplasia. Using immunohistochemistry, entire crypts within 10 cm on each side of colonic adenocarcinomas or advanced colonic neoplasias were found to be frequently reduced or absent in expression for two DNA repair proteins, Pms2 and/or ERCC1. Pms2 is a dual role protein, active in DNA mismatch repair as well as needed in apoptosis of cells with excess DNA damage. ERCC1 is active in DNA nucleotide excision repair. The reduced or absent expression of both ERCC1 and Pms2 would create cells with both increased ability to survive (apoptosis resistance) and increased level of mutability. The reduced or absent expression of both ERCC1 and Pms2 is likely an early step in progression to colon cancer. DNA repair gene Ku86 (active in DNA non-homologous end joining) and Cytochrome c Oxidase Subunit I (involved in apoptosis) had each been reported to be decreased in expression in mucosal areas close to colon cancers. However, immunohistochemical evaluation of their levels of expression showed only low to modest frequencies of crypts to be deficient in their expression in a field defect surrounding colon cancer or surrounding advanced colonic neoplasia. We show, here, our method of evaluation of crypts for expression of ERCC1, Pms2, Ku86 and CcOI. We show that frequency of entire crypts deficient for Pms2 and ERCC1 is often as great as 70% to 95% in 20 cm long areas

  4. Archaeological fieldwork in 2014 / Erki Russow, Arvi Haak, Ulla Kadakas

    Index Scriptorium Estoniae

    Russow, Erki, 1974-

    2015-01-01

    2014. aasta välitöödega seoses võib esile tuua paari olulise uurimisprojekti lõppemist ning välitööde üha suurenevat seotust eeslinnade ning teede ja kommunikatsioonitrasside rajamisega, millele lisanduvat üksikud uusehitiste rajamisest tingitud päästekaevamised. Tabel arheoloogiliste välitööde kohta, objektid esitatud maakondade kaupa

  5. Keelehoolde teoreetilise aluse otsinguil : naabervaldkonnad appi / Arvi Tavast

    Index Scriptorium Estoniae

    Tavast, Arvi, 1969-

    2012-01-01

    Kajastatakse e-keskkonnas läbiviidud küsitluse tulemusi, milles otsiti keele- ja tõlkimisalaste hoiakute seoseid muude teemadega. Küsiti keele olemuse, keelekasutuse, õigeks ja valeks jagamise jne. kohta

  6. Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.

    Directory of Open Access Journals (Sweden)

    Rita A Busuttil

    Full Text Available Non-homologous end joining (NHEJ is thought to be an important mechanism for preventing the adverse effects of DNA double strand breaks (DSBs and its absence has been associated with premature aging. To investigate the effect of inactivated NHEJ on spontaneous mutation frequencies and spectra in vivo and in cultured cells, we crossed a Ku80-deficient mouse with mice harboring a lacZ-plasmid-based mutation reporter. We analyzed various organs and tissues, as well as cultured embryonic fibroblasts, for mutations at the lacZ locus. When comparing mutant with wild-type mice, we observed a significantly higher number of genome rearrangements in liver and spleen and a significantly lower number of point mutations in liver and brain. The reduced point mutation frequency was not due to a decrease in small deletion mutations thought to be a hallmark of NHEJ, but could be a consequence of increased cellular responses to unrepaired DSBs. Indeed, we found a substantial increase in persistent 53BP1 and gammaH2AX DNA damage foci in Ku80-/- as compared to wild-type liver. Treatment of cultured Ku80-deficient or wild-type embryonic fibroblasts, either proliferating or quiescent, with hydrogen peroxide or bleomycin showed no differences in the number or type of induced genome rearrangements. However, after such treatment, Ku80-deficient cells did show an increased number of persistent DNA damage foci. These results indicate that Ku80-dependent repair of DNA damage is predominantly error-free with the effect of alternative more error-prone pathways creating genome rearrangements only detectable after extended periods of time, i.e., in young adult animals. The observed premature aging likely results from a combination of increased cellular senescence and an increased load of stable, genome rearrangements.

  7. Some clastic rocks as parent rocks in beech forests of Brezovica - Južni Kučaj

    Directory of Open Access Journals (Sweden)

    Joksimović Vesna

    2003-01-01

    Full Text Available On the large forest areas, where the measures of soil quality improvement are absent or rarely undertaken, the rocks are the sources of a great number of elements in plant nutrition and one of the factors affecting the contents of some elements in plants. The aim of the study is to determine the differences in the contents of Cu, Zn, Mn, Ni, Fe, Cd, Co, Pb and Cr in the beech leaves developed in the same climate conditions, on morphologically similar terrains, composed of different types of sedimentary rocks. This paper presents the study results of the contents of the above elements in argillites, sandstones (grauwackes and microconglomerates occurring as the parent rocks in high beech forests in the region of GJ Bogovina (Brezovica Južni Kučaj and in the leaves of beech developed on these rocks.

  8. Destruction of gel sulfonated cation-exchangers of the KU-2 type under the influence of hydrogen peroxide

    Energy Technology Data Exchange (ETDEWEB)

    Roginskaya, B.S.; Zavadovskaya, A.S.; Znamenskii, Yu.P.; Paskhina, N.A.; Dobrova, E.I.

    1988-10-20

    The purpose of this work was to study the mechanism of interaction of Soviet sulfonated cation-exchangers of the KU-2 type with hydrogen peroxide. It is shown that under the influence of hydrogen peroxide sulfonated cation-exchangers begin, after a certain induction period, to lose capacity and to release destruction products into water; the length of the induction period increases with the degree of cross-linking. In a given time of contact between the resin and the solution the degree of destruction falls with increase of cross-linking. The principal product of destruction of sulfonated cation-exchangers is an aromatic sulfonic acid containing oxidized groups in the side chains.

  9. Resistance to Sri Lankan Cassava Mosaic Virus (SLCMV) in Genetically Engineered Cassava cv. KU50 through RNA Silencing

    KAUST Repository

    Ntui, Valentine Otang

    2015-04-22

    Cassava ranks fifth among the starch producing crops of the world, its annual bioethanol yield is higher than for any other crop. Cassava cultivar KU50, the most widely grown cultivar for non-food purposes is susceptible to Sri Lankan cassava mosaic virus (SLCMV). The objective of this work was to engineer resistance to SLCMV by RNA interference (RNAi) in order to increase biomass yield, an important aspect for bioethanol production. Here, we produced transgenic KU50 lines expressing dsRNA homologous to the region between the AV2 and AV1 of DNA A of SLCMV. High level expression of dsRNA of SLCMV did not induce any growth abnormality in the transgenic plants. Transgenic lines displayed high levels of resistance to SLCMV compared to the wild-type plants and no virus load could be detected in uninoculated new leaves of the infected resistant lines after PCR amplification and RT-PCR analysis. The agronomic performance of the transgenic lines was unimpaired after inoculation with the virus as the plants presented similar growth when compared to the mock inoculated control plants and revealed no apparent reduction in the amount and weight of tubers produced. We show that the resistance is correlated with post-transcriptional gene silencing because of the production of transgene specific siRNA. The results demonstrate that transgenic lines exhibited high levels of resistance to SLCMV. This resistance coupled with the desirable yield components in the transgenic lines makes them better candidates for exploitation in the production of biomass as well as bioethanol.

  10. Resistance to Sri Lankan Cassava Mosaic Virus (SLCMV) in Genetically Engineered Cassava cv. KU50 through RNA Silencing

    KAUST Repository

    Ntui, Valentine Otang; Kong, Kynet; Khan, Raham Sher; Igawa, Tomoko; Janavi, Gnanaguru Janaky; Rabindran, Ramalingam; Nakamura, Ikuo; Mii, Masahiro

    2015-01-01

    Cassava ranks fifth among the starch producing crops of the world, its annual bioethanol yield is higher than for any other crop. Cassava cultivar KU50, the most widely grown cultivar for non-food purposes is susceptible to Sri Lankan cassava mosaic virus (SLCMV). The objective of this work was to engineer resistance to SLCMV by RNA interference (RNAi) in order to increase biomass yield, an important aspect for bioethanol production. Here, we produced transgenic KU50 lines expressing dsRNA homologous to the region between the AV2 and AV1 of DNA A of SLCMV. High level expression of dsRNA of SLCMV did not induce any growth abnormality in the transgenic plants. Transgenic lines displayed high levels of resistance to SLCMV compared to the wild-type plants and no virus load could be detected in uninoculated new leaves of the infected resistant lines after PCR amplification and RT-PCR analysis. The agronomic performance of the transgenic lines was unimpaired after inoculation with the virus as the plants presented similar growth when compared to the mock inoculated control plants and revealed no apparent reduction in the amount and weight of tubers produced. We show that the resistance is correlated with post-transcriptional gene silencing because of the production of transgene specific siRNA. The results demonstrate that transgenic lines exhibited high levels of resistance to SLCMV. This resistance coupled with the desirable yield components in the transgenic lines makes them better candidates for exploitation in the production of biomass as well as bioethanol.

  11. Exposure to power frequency magnetic fields suppresses X-ray-induced apoptosis transiently in Ku80-deficient xrs5 cells

    International Nuclear Information System (INIS)

    Tian, Furong; Nakahara, Takehisa; Yoshida, Masami; Honda, Naoko; Hirose, Hideki; Miyakoshi, Junji

    2002-01-01

    In an attempt to determine whether exposure to extremely low frequency (ELF) electromagnetic fields can affect cells, Ku80-deficient cells (xrs5) and Ku80-proficient cells (CHO-K1) were exposed to ELF electromagnetic fields. Cell survival, and the levels of the apoptosis-related genes p21, p53, phospho-p53 (Ser 15 ), caspase-3 and the anti-apoptosis gene bcl-2 were determined in xrs5 and CHO-K1 cells following exposure to ELF electromagnetic fields and X-rays. It was found that exposure of xrs5 and CHO-K1 cells to 60 Hz ELF electromagnetic fields had no effect on cell survival, cell cycle distribution and protein expression. Exposure of xrs5 cells to 60 Hz ELF electromagnetic fields for 5 h after irradiation significantly inhibited G 1 cell cycle arrest induced by X-rays (1 Gy) and resulted in elevated bcl-2 expression. A significant decrease in the induction of p53, phospho-p53, caspase-3 and p21 proteins was observed in xrs5 cells when irradiation by X-rays (8 Gy) was followed by exposure to 5 mT ELF magnetic fields. Exposure of xrs5 cells to the ELF electromagnetic fields for 10 h following irradiation significantly decreased X-ray-induced apoptosis from about 1.7% to 0.7%. However, this effect was not found in CHO-K1 cells within 24 h of irradiation by X-rays alone and by X-rays combined with ELF electromagnetic fields. Exposure of xrs5 cells to 60 Hz ELF electromagnetic fields following irradiation can affect cell cycle distribution and transiently suppress apoptosis by decreasing the levels of caspase-3, p21, p53 and phospho-p53 and by increasing bcl-2 expression

  12. Go Group andis avalöögi / Erki Freiberg

    Index Scriptorium Estoniae

    Freiberg, Erki

    2005-01-01

    Go Group on omandanud 17 turismi- ja reisijateveo ning nende tegevusvaldkondadega seotud ettevõtet ning planeerib selle aasta käibeks üle 600 miljoni krooni. Vt. samas: Go Groupi kuuluv Tarbus asub võitlusse soodsama transpordipoliitika nimel. Diagramm: Omanikud

  13. Gazprom ähvardab hinnatõusuga / Erki Freiberg

    Index Scriptorium Estoniae

    Freiberg, Erki

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 15. juuni lk. 4. Gaasitootja Gazprom tahab kehtestada Eestile ning Lätile gaasi müümisel sama hinnataseme, mis kehtib ka teistel Euroopa Liidu liikmesriikidel, see tähendaks kahekordset hinnatõusu. Lisa: Hinnatõus muudaks gaasikütte elektriküttega võrreldavaks. Vt. samas: Eesti Gaasi juht: hüppelist hinnatõusu ei tule

  14. Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome

    International Nuclear Information System (INIS)

    Mimori, Tsuneyo; Ohosone, Yasuo; Hama, Nobuaki; Suwa, Akira; Akizuki, Masashi; Homma, Mitsuo; Griffith, A.J.; Hardin, J.A.

    1990-01-01

    Anti-Ku (p70/p80) autoantibodies in patients with scleroderma-polymyositis overlap syndrome recognize a 70-kDa/80-kDa protein heterodimer which binds to terminal regions of double-stranded DNA. In the present study, the authors isolated full-length cDNAs that encode the 80-kDa Ku subunit. Initial screening of a human spleen cDNA library with anti-Ku antibodies yielded a cDNA of 1.0 kilobase (kb) (termed K71) encoding a portion of the 80-kDa Ku polypeptide (identification based on immunological criteria). In RNA blots, this cDNA hybridized with two mRNAs of 3.4 and 2.6 kb. In vitro transcription and translation experiments produced an immunoprecipitable polypeptide which comigrated with the 80-kDa Ku subunit. The Ku80-6 cDNA proved to be 3304 nucleotides in length, with an additional poly(A) tail, closely approximating the size of the larger mRNA. It contains a single long open reading frame encoding 732 amino acids. The putative polypeptide has a high content of acidic amino acids and a region with periodic repeat of leucine in every seventh position which may form the leucine zipper structure. In genomic DNA blots, probes derived from the opposite ends of cDNA Ku80-6 hybridized with several nonoverlapping restriction fragments from human leukocyte DNA, indicating that the gene encoding the 80-kDa Ku polypeptide is divided into several exons by intervening sequences

  15. Detailed modeling of local anisotropy and transverse Ku interplay regarding hysteresis loop in FeCuNbSiB nanocrystalline ribbons

    Science.gov (United States)

    Geoffroy, Olivier; Boust, Nicolas; Chazal, Hervé; Flury, Sébastien; Roudet, James

    2018-04-01

    This article focuses on the modeling of the hysteresis loop featured by Fe-Cu-Nb-Si-B nanocrystalline alloys with transverse induced anisotropy. The magnetization reversal process of a magnetic correlated volume (CV), characterized by the induced anisotropy Ku, and a deviation of the local easy magnetization direction featuring the effect of a local incoherent anisotropy Ki, is analyzed, taking account of magnetostatic interactions. Solving the equations shows that considering a unique typical kind of CV does not enable accounting for both the domain pattern and the coercivity. Actually, the classical majority CVs obeying the random anisotropy model explains well the domain pattern but considering another kind of CVs, minority, mingled with classical ones, featuring a magnitude of Ki comparable to Ku, is necessary to account for coercivity. The model has been successfully compared with experimental data.

  16. Origin of absorption peaks in reflection loss spectrum in Ku- frequency band of Co-Zr substituted strontium hexaferrites prepared using sucrose precursor

    Energy Technology Data Exchange (ETDEWEB)

    Narang, Sukhleen Bindra, E-mail: sukhleen2@yahoo.com [Department of Electronics Technology, Guru Nanak Dev University, Amritsar (India); Pubby, Kunal, E-mail: kunalpubby02@gmail.com [Department of Electronics Technology, Guru Nanak Dev University, Amritsar (India); Chawla, S.K., E-mail: sschawla118@gmail.com [Department of Chemistry, Centre for Advanced Studies-I, Guru Nanak Dev University, Amritsar (India); Kaur, Prabhjyot, E-mail: prabhjyot.2525@gmail.com [Department of Chemistry, Centre for Advanced Studies-I, Guru Nanak Dev University, Amritsar (India)

    2017-03-15

    This study presents the detailed explanation of the factors, contributing towards the absorption peaks in reflection loss spectrum of hexaferrites. Cobalt-Zirconium substituted strontium hexaferrites, synthesized using sucrose precursor sol-gel technique, were analyzed in 12.4–18 GHz frequency range. The concepts of impedance matching through quarter wavelength condition, complex thickness, dielectric phase angle and attenuation constant have been used to determine the location as well as intensity of absorption peaks. This study also demonstrates the potential application of three compositions of this series with doping content (x)==0.0, 0.6 and 0.8 as an effective microwave absorbers in Ku-frequency band. - Highlights: • EM analysis of Sr Hexaferrites in Ku-band. • Factors towards absorption peak intensity & location.

  17. Volba řešitelských strategií v závislosti na věku

    Directory of Open Access Journals (Sweden)

    Petr Eisenmann

    2017-12-01

    Full Text Available Příspěvek popisuje experiment, který byl součástí dlouhodobého výzkumu Rozvíjení kultury řešení matematických problémů ve školské praxi. Experiment byl proveden na vzorku celkem 584 respondentů ve věku 11–17 let a mapuje vývoj ve volbě řešitelských strategií matematických úloh u různých věkových skupin žáků. Žákům 6. a 8. ročníku základní školy, I. a III. ročníku střední školy byly předloženy tři úlohy, které se dají efektivně řešit pomocí heuristických strategií. Kromě úspěšnosti řešení úloh byla věnována pozornost také způsobu jejich řešení. Výsledkem experimentu je zjištění, že existují heuristické strategie, které žáci použili při řešení úloh i přesto, že s nimi ve výuce nebyli seznámeni. U některých z nich se jejich výskyt nemění v závislosti na věku.

  18. A creative approach to the development of an agenda for knowledge utilization: outputs from the 11th international knowledge utilization colloquium (KU 11).

    Science.gov (United States)

    Wilkinson, Joyce E; Rycroft-Malone, Jo; Davies, Huw T O; McCormack, Brendan

    2012-12-01

    A group of researchers and practitioners interested in advancing knowledge utilization met as a colloquium in Belfast (KU 11) and used a "world café" approach to exploit the social capital and shared understanding built up over previous events to consider the research and practice agenda. We considered three key areas of relevance to knowledge use: (1) understanding the nature of research use, influence and impact; (2) blended and collaborative approaches to knowledge production and use; and (3) supporting sustainability and spread of evidence-informed innovations. The approach enabled the development of artifacts that reflected the three areas and these were analyzed using a creative hermeneutic approach. The themes that emerged and which are outlined in this commentary are not mutually exclusive. There was much overlap in the discussions and therefore of the themes, reflecting the complex nature of knowledge translation work. The agenda that has emerged from KU 11 also reflects the participatory and creative approach in which the meeting was structured and focused, and therefore emphasizes the processual, relational and contingent nature of some of the challenges we face. The past 20 years has seen an explosion in activity around understanding KU, and we have learned much about the difficulties. Whilst the agenda for the next decade may be becoming clearer, colloquia such as KU 11, using creative and engaging approaches, have a key role to play in dissecting, articulating and sharing that agenda. In this way, we also build an ever-expanding international community that is dedicated to working towards increasing the chances of success for better patient care. © 2012 Sigma Theta Tau International.

  19. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.

    Science.gov (United States)

    Boboila, Cristian; Jankovic, Mila; Yan, Catherine T; Wang, Jing H; Wesemann, Duane R; Zhang, Tingting; Fazeli, Alex; Feldman, Lauren; Nussenzweig, Andre; Nussenzweig, Michel; Alt, Frederick W

    2010-02-16

    Class switch recombination (CSR) in B lymphocytes is initiated by introduction of multiple DNA double-strand breaks (DSBs) into switch (S) regions that flank immunoglobulin heavy chain (IgH) constant region exons. CSR is completed by joining a DSB in the donor S mu to a DSB in a downstream acceptor S region (e.g., S gamma1) by end-joining. In normal cells, many CSR junctions are mediated by classical nonhomologous end-joining (C-NHEJ), which employs the Ku70/80 complex for DSB recognition and XRCC4/DNA ligase 4 for ligation. Alternative end-joining (A-EJ) mediates CSR, at reduced levels, in the absence of C-NHEJ, even in combined absence of Ku70 and ligase 4, demonstrating an A-EJ pathway totally distinct from C-NHEJ. Multiple DSBs are introduced into S mu during CSR, with some being rejoined or joined to each other to generate internal switch deletions (ISDs). In addition, S-region DSBs can be joined to other chromosomes to generate translocations, the level of which is increased by absence of a single C-NHEJ component (e.g., XRCC4). We asked whether ISD and S-region translocations occur in the complete absence of C-NHEJ (e.g., in Ku70/ligase 4 double-deficient B cells). We found, unexpectedly, that B-cell activation for CSR generates substantial ISD in both S mu and S gamma1 and that ISD in both is greatly increased by the absence of C-NHEJ. IgH chromosomal translocations to the c-myc oncogene also are augmented in the combined absence of Ku70 and ligase 4. We discuss the implications of these findings for A-EJ in normal and abnormal DSB repair.

  20. New uranium chalcoantimonates, RbU{sub 2}SbS{sub 8} and KU{sub 2}SbSe{sub 8}, with a polar noncentrosymmetric structure

    Energy Technology Data Exchange (ETDEWEB)

    Choi, K S; Kanatzidis, M G

    1999-09-01

    The new compounds, RbU{sub 2}SbS{sub 8} and KU{sub 2}SbSe{sub 8}, were prepared as golden-black, blocklike crystals by the polychalcogenide molten flux method. RbU{sub 2}SbS{sub 8} has a two-dimensional character with layers running perpendicular to the c-axis. The coordination geometry around the U{sup 4+} atoms is best described as a bicapped trigonal prism. The trigonal prisms share triangular faces with neighboring prisms, forming one-dimensional columns along the a-axis. The columns are then joined to construct sheets by sharing capping S atoms. Sb{sup 3+} ions are sitting at the center of a slightly distorted seesaw coordination environment (CN = 4). Rb{sup +} ions are stabilized in 8-coordinate bicapped trigonal prismatic sites. KU{sub 2}SbSe{sub 8} has essentially the same structure as RbU{sub 2}SbS{sub 8}. However, Sb{sup 3+} and K{sup +} ions appear disordered in every other layer resulting in a different unit cell. RbU{sub 2}SbS{sub 8} is a semiconductor with a band gap of 1.38 eV. The band gap of KU{sub 2}SbSe{sub 8} could not be determined precisely due to the presence of overlapping intense f-f transitions in the region (0.5--1.1 eV). The Raman spectra show the disulfide stretching vibration in RbU{sub 2}SbS{sub 8} at 479 cm{sup {minus}1} and the diselenide stretching vibration in KU{sub 2}SbSe{sub 8} at 252 cm{sup {minus}1}. Magnetic susceptibility measurements indicate the presence of U{sup 4+} centers in the compounds. The compounds do not melt below 1,000 C under vacuum.

  1. The impact of the snow cover on sea-ice thickness products retrieved by Ku-band radar altimeters

    Science.gov (United States)

    Ricker, R.; Hendricks, S.; Helm, V.; Perovich, D. K.

    2015-12-01

    Snow on sea ice is a relevant polar climate parameter related to ocean-atmospheric interactions and surface albedo. It also remains an important factor for sea-ice thickness products retrieved from Ku-band satellite radar altimeters like Envisat or CryoSat-2, which is currently on its mission and the subject of many recent studies. Such satellites sense the height of the sea-ice surface above the sea level, which is called sea-ice freeboard. By assuming hydrostatic equilibrium and that the main scattering horizon is given by the snow-ice interface, the freeboard can be transformed into sea-ice thickness. Therefore, information about the snow load on hemispherical scale is crucial. Due to the lack of sufficient satellite products, only climatological values are used in current studies. Since such values do not represent the high variability of snow distribution in the Arctic, they can be a substantial contributor to the total sea-ice thickness uncertainty budget. Secondly, recent studies suggest that the snow layer cannot be considered as homogenous, but possibly rather featuring a complex stratigraphy due to wind compaction and/or ice lenses. Therefore, the Ku-band radar signal can be scattered at internal layers, causing a shift of the main scattering horizon towards the snow surface. This alters the freeboard and thickness retrieval as the assumption that the main scattering horizon is given by the snow-ice interface is no longer valid and introduces a bias. Here, we present estimates for the impact of snow depth uncertainties and snow properties on CryoSat-2 sea-ice thickness retrievals. We therefore compare CryoSat-2 freeboard measurements with field data from ice mass-balance buoys and aircraft campaigns from the CryoSat Validation Experiment. This unique validation dataset includes airborne laser scanner and radar altimeter measurements in spring coincident to CryoSat-2 overflights, and allows us to evaluate how the main scattering horizon is altered by the

  2. Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80▿ †

    Science.gov (United States)

    Wei, Leizhen; Lan, Li; Hong, Zehui; Yasui, Akira; Ishioka, Chikashi; Chiba, Natsuko

    2008-01-01

    BRCA1 is the first susceptibility gene to be linked to breast and ovarian cancers. Although mounting evidence has indicated that BRCA1 participates in DNA double-strand break (DSB) repair pathways, its precise mechanism is still unclear. Here, we analyzed the in situ response of BRCA1 at DSBs produced by laser microirradiation. The amino (N)- and carboxyl (C)-terminal fragments of BRCA1 accumulated independently at DSBs with distinct kinetics. The N-terminal BRCA1 fragment accumulated immediately after laser irradiation at DSBs and dissociated rapidly. In contrast, the C-terminal fragment of BRCA1 accumulated more slowly at DSBs but remained at the sites. Interestingly, rapid accumulation of the BRCA1 N terminus, but not the C terminus, at DSBs depended on Ku80, which functions in the nonhomologous end-joining (NHEJ) pathway, independently of BARD1, which binds to the N terminus of BRCA1. Two small regions in the N terminus of BRCA1 independently accumulated at DSBs and interacted with Ku80. Missense mutations found within the N terminus of BRCA1 in cancers significantly changed the kinetics of its accumulation at DSBs. A P142H mutant failed to associate with Ku80 and restore resistance to irradiation in BRCA1-deficient cells. These might provide a molecular basis of the involvement of BRCA1 in the NHEJ pathway of the DSB repair process. PMID:18936166

  3. Vecāku pedagoģiskās kompetences pilnveide pirmsskolas izglītības iestāde

    OpenAIRE

    Vītola, Aija

    2015-01-01

    Maģistra darba autore Aija Vītola. Maģistra darba nosaukums „Vecāku pedagoģiskās kompetences pilnveide pirmsskolas izglītības iestādē”. Maģistra darba mērķis: izpētīt vecāku pedagoģiskās kompetences pilnveides iespējas pirmsskolas izglītības iestādē. Darba zinātniski teorētisko daļu veido: 1,5 – 3 gadus vecu bērnu personības attīstības likumsakarības, problēmas, ar kurām vecāki sastopas, bērnam uzsākot gaitas pirmsskolas izglītības iestādē, kompetences jēdziens, būtība, veidi, vecāku ...

  4. Study of sea-surface slope distribution and its effect on radar backscatter based on Global Precipitation Measurement Ku-band precipitation radar measurements

    Science.gov (United States)

    Yan, Qiushuang; Zhang, Jie; Fan, Chenqing; Wang, Jing; Meng, Junmin

    2018-01-01

    The collocated normalized radar backscattering cross-section measurements from the Global Precipitation Measurement (GPM) Ku-band precipitation radar (KuPR) and the winds from the moored buoys are used to study the effect of different sea-surface slope probability density functions (PDFs), including the Gaussian PDF, the Gram-Charlier PDF, and the Liu PDF, on the geometrical optics (GO) model predictions of the radar backscatter at low incidence angles (0 deg to 18 deg) at different sea states. First, the peakedness coefficient in the Liu distribution is determined using the collocations at the normal incidence angle, and the results indicate that the peakedness coefficient is a nonlinear function of the wind speed. Then, the performance of the modified Liu distribution, i.e., Liu distribution using the obtained peakedness coefficient estimate; the Gaussian distribution; and the Gram-Charlier distribution is analyzed. The results show that the GO model predictions with the modified Liu distribution agree best with the KuPR measurements, followed by the predictions with the Gaussian distribution, while the predictions with the Gram-Charlier distribution have larger differences as the total or the slick filtered, not the radar filtered, probability density is included in the distribution. The best-performing distribution changes with incidence angle and changes with wind speed.

  5. A Ku band pulsed electron paramagnetic resonance spectrometer using an arbitrary waveform generator for quantum control experiments at millikelvin temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Yap, Yung Szen, E-mail: yungszen@utm.my [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka-shi, Osaka 560-8531 (Japan); Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor (Malaysia); Tabuchi, Yutaka [Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Meguro-ku, Tokyo 153-8904 (Japan); Negoro, Makoto; Kagawa, Akinori; Kitagawa, Masahiro, E-mail: kitagawa@ee.es.osaka-u.ac.jp [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka-shi, Osaka 560-8531 (Japan)

    2015-06-15

    We present a 17 GHz (Ku band) arbitrary waveform pulsed electron paramagnetic resonance spectrometer for experiments down to millikelvin temperatures. The spectrometer is located at room temperature, while the resonator is placed either in a room temperature magnet or inside a cryogen-free dilution refrigerator; the operating temperature range of the dilution unit is from ca. 10 mK to 8 K. This combination provides the opportunity to perform quantum control experiments on electron spins in the pure-state regime. At 0.6 T, spin echo experiments were carried out using γ-irradiated quartz glass from 1 K to 12.3 mK. With decreasing temperatures, we observed an increase in spin echo signal intensities due to increasing spin polarizations, in accordance with theoretical predictions. Through experimental data fitting, thermal spin polarization at 100 mK was estimated to be at least 99%, which was almost pure state. Next, to demonstrate the ability to create arbitrary waveform pulses, we generate a shaped pulse by superposing three Gaussian pulses of different frequencies. The resulting pulse was able to selectively and coherently excite three different spin packets simultaneously—a useful ability for analyzing multi-spin system and for controlling a multi-qubit quantum computer. By applying this pulse to the inhomogeneously broadened sample, we obtain three well-resolved excitations at 8 K, 1 K, and 14 mK.

  6. Comparison of neutron and gamma irradiation effects on KU1 fused silica monitored by electron paramagnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Bravo, D. [Department Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain)], E-mail: david.bravo@uam.es; Lagomacini, J.C. [Department Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Leon, M.; Martin, P. [Materiales para Fusion, CIEMAT, Avda. Complutense 22, E-28040 Madrid (Spain); Martin, A. [Department Fisica e Instalaciones, ETS Arquitectura UPM, E-28040 Madrid (Spain); Lopez, F.J. [Department Fisica de Materiales, Universidad Autonoma de Madrid, E-28049 Madrid (Spain); Ibarra, A. [Materiales para Fusion, CIEMAT, Avda. Complutense 22, E-28040 Madrid (Spain)

    2009-06-15

    Electron paramagnetic resonance (EPR) studies have been carried out on KU1 fused silica irradiated with neutrons at fluences 10{sup 21} and 10{sup 22} n/m{sup 2}, and gamma-ray doses up to 12 MGy. The effects of post-irradiation thermal annealing treatments, up to 850 deg. C, have also been investigated. Paramagnetic oxygen-related defects (POR and NBOHC) and E'-type defects have been identified and their concentration has been measured as a function of neutron fluence, gamma dose and post-irradiation annealing temperature. It is found that neutrons at the highest fluence generate a much higher concentration of defects (mainly E' and POR, both at concentrations about 5 x 10{sup 18} spins/cm{sup 3}) than gamma irradiations at the highest dose (mainly E' at a concentration about 4 x 10{sup 17} spins/cm{sup 3}). Moreover, for gamma-irradiated samples a lower treatment temperature (about 400 deg. C) is required to annihilate most of the observed defects than for neutron-irradiated ones (about 600 deg. C)

  7. Tracking- and Scintillation-Aware Channel Model for GEO Satellite to Land Mobile Terminals at Ku-Band

    Directory of Open Access Journals (Sweden)

    Ali M. Al-Saegh

    2015-01-01

    Full Text Available Recent advances in satellite to land mobile terminal services and technologies, which utilize high frequencies with directional antennas, have made the design of an appropriate model for land mobile satellite (LMS channels a necessity. This paper presents LMS channel model at Ku-band with features that enhance accuracy, comprehensiveness, and reliability. The effect of satellite tracking loss at different mobile terminal speeds is considered for directional mobile antenna systems, a reliable tropospheric scintillation model for an LMS scenario at tropical and temperate regions is presented, and finally a new quality indicator module for different modulation and coding schemes is included. The proposed extended LMS channel (ELMSC model is designed based on actual experimental measurements and can be applied to narrow- and wide-band signals at different regions and at different speeds and multichannel states. The proposed model exhibits lower root mean square error (RMSE and significant performance observation compared with the conventional model in terms of the signal fluctuations, fade depth, signal-to-noise ratio (SNR, and quality indicators accompanied for several transmission schemes.

  8. Kinetic modelling and optimisation of antimicrobial compound production by Candida pyralidae KU736785 for control of Candida guilliermondii.

    Science.gov (United States)

    Mewa-Ngongang, Maxwell; du Plessis, Heinrich W; Hutchinson, Ucrecia F; Mekuto, Lukhanyo; Ntwampe, Seteno Ko

    2017-06-01

    Biological antimicrobial compounds from yeast can be used to address the critical need for safer preservatives in food, fruit and beverages. The inhibition of Candida guilliermondii, a common fermented beverage spoilage organism, was achieved using antimicrobial compounds produced by Candida pyralidae KU736785. The antimicrobial production system was modelled and optimised using response surface methodology, with 22.5 ℃ and pH of 5.0 being the optimum conditions. A new concept for quantifying spoilage organism inhibition was developed. The inhibition activity of the antimicrobial compounds was observed to be at a maximum after 17-23 h of fermentation, with C. pyralidae concentration being between 0.40 and 1.25 × 10 9 CFU ml -1 , while its maximum specific growth rate was 0.31-0.54 h -1 . The maximum inhibitory activity was between 0.19 and 1.08 l contaminated solidified media per millilitre of antimicrobial compound used. Furthermore, the antimicrobial compound formation rate was 0.037-0.086 l VZI ml -1 ACU h -1 , respectively. The response surface methodology analysis showed that the model developed sufficiently described the antimicrobial compound formation rate 1.08 l VZI ml -1 ACU, as 1.17 l VZI ml -1 ACU, predicted under the optimum production conditions.

  9. Teplovodní výměník pro krbovou vložku

    OpenAIRE

    Kněžínek, Petr

    2012-01-01

    Diplomová práce je zaměřena na problematiku zapojení krbových kamen a krbových vložek do teplovodních vytápěcích systémů. Práce obsahuje stručný popis krbů a otopných soustav. Konkrétně se zabývá návrhem teplovodního výměníku pro krbová kamna. Poslední část práce je věnována experimentálnímu ověření provozních parametrů a vyhodnocení získaných výsledků. The diploma thesis is focused on problems connecting of fireplace with water heating systems. The thesis comprises concise description of ...

  10. High-performance 16-way Ku-band radial power combiner based on the TE01-circular waveguide mode

    Science.gov (United States)

    Montejo-Garai, José R.; Saracho-Pantoja, Irene O.; Ruiz-Cruz, Jorge A.; Rebollar, Jesús M.

    2018-03-01

    This work presents a 16-way Ku-band radial power combiner for high power and high frequency applications, using the very low loss TE01 circular waveguide mode. The accomplished design shows an excellent performance: the experimental prototype has a return loss better than 30 dB, with a balance for the amplitudes of (±0.15 dB) and (±2.5°) for the phases, in a 16.7% fractional bandwidth (2 GHz centered at 12 GHz). For obtaining these outstanding specifications, required, for instance, in high-frequency amplification or on plasma systems, a rigorous step-by-step procedure is presented. First, a high-purity mode transducer has been designed, from the TE10 mode in the rectangular waveguide to the TE01 mode in the circular waveguide, with very high attenuation (>50 dB) for the other propagating and evanescent modes in the circular waveguide. This transducer has been manufactured and measured in a back-to-back configuration, validating the design process. Second, an E-plane 16-way radial power divider has been designed, where the power is coupled from the 16 non-reduced-height radial standard waveguides into the TE01 circular waveguide mode, improving the insertion loss response and removing the usual tapered transformers of previous designs limiting the power handling. Finally, both the transducer and the divider have been assembled to make the final radial combiner. The prototype has been carefully manufactured, showing very good agreement between the measurements and the full-wave simulations.

  11. Simulation study for ground-based Ku-band microwave observations of ozone and hydroxyl in the polar middle atmosphere

    Science.gov (United States)

    Newnham, David; Clilverd, Mark; Kosch, Michael; Verronen, Pekka

    2017-04-01

    Commercial satellite TV broadcasting is possible due to remarkable advances in microwave electronics, enabling weak signals transmitted over 36,000 km from geostationary orbit to be received by inexpensive rooftop dishes. The Ku band satellite frequencies (10.70-14.25 GHz) overlap microwave emissions from ozone (O3) at 11.072 GHz and hydroxyl radical (OH) at 13.44 GHz. These important chemical species in the polar middle atmosphere respond strongly to solar variability and, at high latitudes, geomagnetic activity associated with space weather. Atmospheric model calculations predict that energetic electron precipitation (EEP) driven by magnetospheric substorms produces large changes in polar mesospheric O3 and OH. The EEP typically peaks at geomagnetic latitudes ˜65˚ (e.g. Kilpisjärvi, Finland and Syowa station, Antarctica) and evolves rapidly with time eastwards and over the geomagnetic latitude range 60˚ -80˚ (e.g. reaching Halley, Antarctica). During the substorms OH can increase by more than 1000% at 64-84 km. The substorms leave footprints of 5-55% O3 loss lasting many hours of local time, with strong altitude and seasonal dependences. An atmospheric simulation and retrieval study is performed to determine the specification and design requirements for microwave radiometers capable of measuring O3 and OH profiles from Arctic and Antarctic locations using accessible satellite TV receiver technology. The proposed observations are highly applicable to studies of EEP, atmospheric dynamics, planetaryscale circulation, chemical transport, and the representation of these processes in polar and global climate models. They would provide a lowcost, reliable alternative to increasingly sparse satellite measurements, extending long-term data records and also providing "ground truth" calibration data.

  12. Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology.

    Science.gov (United States)

    Malyarchuk, Svitlana; Wright, Douglas; Castore, Reneau; Klepper, Emily; Weiss, Bernard; Doherty, Aidan J; Harrison, Lynn

    2007-10-01

    Unlike Escherichia coli, Mycobacterium tuberculosis (Mt) expresses a Ku-like protein and an ATP-dependent DNA ligase that can perform non-homologous end-joining (NHEJ). We have expressed the Mt-Ku and Mt-Ligase D in E. coli using an arabinose-inducible promoter and expression vectors that integrate into specific sites in the E. coli chromosome. E. coli strains have been generated that express the Mt-Ku and Mt-Ligase D on a genetic background that is wild-type for repair, or deficient in either the RecA or RecB protein. Transformation of these strains with linearized plasmid DNA containing a 2bp overhang has demonstrated that expression of both the Mt-Ku and Mt-Ligase D is required for DNA end-joining and that loss of RecA does not prevent this double-strand break repair. Analysis of the re-joined plasmid has shown that repair is predominantly inaccurate and results in the deletion of sequences. Loss of RecB did not prevent the formation of large deletions, but did increase the amount of end-joining. Sequencing the junctions has revealed that the majority of the ligations occurred at regions of microhomology (1-4bps), eliminating one copy of the homologous sequence at the junction. The Mt-Ku and Mt-Ligase D can therefore function in E. coli to re-circularize linear plasmid.

  13. Serial blood donations for intrauterine transfusions of severe hemolytic disease of the newborn with the use of recombinant erythropoietin in a pregnant woman alloimmunized with anti-Ku.

    Science.gov (United States)

    Lydaki, Evaggelia; Nikoloudi, Irene; Kaminopetros, Petros; Bolonaki, Irene; Sifakis, Stavros; Kikidi, Katerina; Koumantakis, Evgenios; Foundouli, Kaliopi

    2005-11-01

    The management of a pregnant woman with the rare Ko phenotype and anti-Ku is a special challenge, because matched blood is extremely rare and the possibility of severe hemolytic disease of the newborn is high. A 30-year-old woman with rare Ko (Knull) phenotype presented at 18 weeks of gestation with positive indirect agglutination test results. She had anti-Ku due to previous blood transfusion, one pregnancy, and two abortions. During this pregnancy, anti-Ku titers ranged from 1024 to 4096. At the 26th week of gestation ultrasound showed a hydropic fetus and urgent intrauterine exchange transfusion was performed with the maternal red blood cells (RBCs). Recombinant human erythropoietin (rHu-EPO) and intravenous (IV) iron were administered to the mother to ensure an adequate supply of matched RBCs for intrauterine transfusions and possible perinatal hemorrhage. Intrauterine transfusions were repeated every 1 to 3 weeks. By 35 weeks 2 days of gestation, the mother had donated 4 units of blood, and four intrauterine transfusions had been performed. Cesarean section was then decided and a healthy male newborn was born. He was treated with phototherapy but without exchange transfusions. By the 15th day of life rHu-EPO was administrated to the newborn because of anemia. The maternal RBCs completely disappeared from the child's blood by Day 100. As shown in this case, treatment with rHu-EPO and IV Fe has effectively increased the mother's capacity to donate RBCs for autologous use and intrauterine transfusions, with no adverse effects to the mother or the child.

  14. Wpływ wysiłku fizycznego na funkcję układu oddechowego w twardzinie układowej

    Directory of Open Access Journals (Sweden)

    Stanisław Sierakowski

    2010-12-01

    Full Text Available Cel: Powikłania ze strony układu oddechowego stanowią główną przyczynę zgonów pacjentów z twardziną układową (TU. Tętniczenadciśnienie płucne i śródmiąższowa choroba płuc stanowią najistotniejszez nich. Pacjenci są jednak często zdiagnozowani dopierow późnym okresie choroby, dlatego też istotne jest opracowaniemetody diagnostycznej do wczesnego wykrywania tych powikłań.Celem pracy była ocena wpływu wysiłku fizycznego na zmiany parametrówoddechowych. Materiały i metody: Badania przeprowadzono wśród 32 pacjentów zezdiagnozowaną TU; 72% pacjentów miało postać ograniczoną TU,28% postać uogólnioną. Wykonywano pomiar zdolności dyfuzyjnejpłuc dla tlenku węgla (DLCO, natężonej pojemności życiowej (FVC,natężonej objętości wydechowej pierwszosekundowej (FEV1 orazcałkowitej pojemności płuc (TLC w spoczynku oraz bezpośrednio pozakończeniu wysiłku fizycznego. Wyniki: Pod wpływem wysiłku fizycznego obserwowano wzrostDLCO od 59,7% do 68,1% wartości należnej (p < 0,005. Nie stwierdzononatomiast istotnych statystycznie zmian wartości FVC, FEV1oraz TLC. Wnioski: U chorych na TU zdolność dyfuzyjna płuc dla tlenku węglapo wysiłku fizycznym uległa istotnej statystycznie poprawiew porównaniu z wartościami spoczynkowymi. Związane jest toz koniecznością zapewnienia właściwego utlenowania krwi tętniczeji wynika m.in. ze zwiększenia pojemności łożyska naczyniowego.W klinicznej interpretacji wartości DLCO należy uwzględniać opróczstężenia hemoglobiny i objętości pęcherzykowej także wpływ wysiłkuoraz związane z nim zmiany wielkości objętości rzutu serca.

  15. Cave bear (Ursus spelaeus Rosenmüller & Heinroth males' den from Velika Pećina in Duboka Near Kučevo, Eastern Serbia

    Directory of Open Access Journals (Sweden)

    Dimitrijević Vesna M.

    2002-01-01

    Full Text Available More a 100 years after the first research in the cave Velika pećina in Duboka near Kučevo cave bear remains were discovered in a small chamber cut off from the passable channels by a 7 m high slope. A whole skull, bones of a forearm in articulation, and other skeleton parts were laying on the cave floor encrusted in travertine cover and in some places overgrown by stalagmites. Bones belonged to adult males, which found there the shelter to hibernate, in a short epizode that ended by closing the channels that once linked this part of the cave to a surface.

  16. Prokaryotic Homologs of the Eukaryotic 3-Hydroxyanthranilate 3,4-Dioxygenase and 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase in the 2-Nitrobenzoate Degradation Pathway of Pseudomonas fluorescens Strain KU-7†

    OpenAIRE

    Muraki, Takamichi; Taki, Masami; Hasegawa, Yoshie; Iwaki, Hiroaki; Lau, Peter C. K.

    2003-01-01

    The 2-nitrobenzoic acid degradation pathway of Pseudomonas fluorescens strain KU-7 proceeds via a novel 3-hydroxyanthranilate intermediate. In this study, we cloned and sequenced a 19-kb DNA locus of strain KU-7 that encompasses the 3-hydroxyanthranilate meta-cleavage pathway genes. The gene cluster, designated nbaEXHJIGFCDR, is organized tightly and in the same direction. The nbaC and nbaD gene products were found to be novel homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase a...

  17. The Comparison of Canopy Height Profiles Extracted from Ku-band Profile Radar Waveforms and LiDAR Data

    Directory of Open Access Journals (Sweden)

    Hui Zhou

    2018-05-01

    Full Text Available An airborne Ku-band frequency-modulated continuous waveform (FM-CW profiling radar, Tomoradar, records the backscatter signal from the canopy surface and the underlying ground in the southern boreal forest zone of Finland. The recorded waveforms are transformed into canopy height profiles (CHP with a similar methodology utilized in large-footprint light detection and ranging (LiDAR. The point cloud data simultaneously collected by a Velodyne® VLP-16 LiDAR on-board the same platform represent the frequency of discrete returns, which are also applied to the extraction of the CHP by calculating the gap probability and incremental distribution. To thoroughly explore the relationships of the CHP derived from Tomoradar waveforms and LiDAR data we utilized the effective waveforms of one-stripe field measurements and comparison them with four indicators, including the correlation coefficient, the root-mean-square error (RMSE of the difference, and the coefficient of determination and the RMSE of residuals of linear regression. By setting the Tomoradar footprint as 20 degrees to contain over 95% of the transmitting energy of the main lobe, the results show that 88.17% of the CHPs derived from Tomoradar waveforms correlated well with those from the LiDAR data; 98% of the RMSEs of the difference ranged between 0.002 and 0.01; 79.89% of the coefficients of determination were larger than 0.5; and 98.89% of the RMSEs of the residuals ranged from 0.001 to 0.01. Based on the investigations, we discovered that the locations of the greatest CHP derived from the Tomoradar were obviously deeper than those from the LiDAR, which indicated that the Tomoradar microwave signal had a stronger penetration capability than the LiDAR signal. Meanwhile, there are smaller differences (the average RMSEs of differences is only 0.0042 when the total canopy closure is less than 0.5 and better linear regression results in an area with a relatively open canopy than with a denser

  18. Environmental radiation status in Bunkyo-ku, Tokyo, after the TEPCO Fukushima Dai-ichi Nuclear Power Plant disaster

    International Nuclear Information System (INIS)

    Ebisawa, Takao; Hirose, Seiichi; Furuta, Etsuko; Kusama, Keiji; Iimoto, Takeshi

    2013-01-01

    Bunkyo-ku is located in the eastern part of the metropolitan area of Tokyo, Japan, and is roughly 220 km south of the TEPCO Fukushima Dai-ichi Nuclear Power Plant. The population of the city was 201,079 as of August 1, 2012, and its area is 11.31 km"2. The local government has officially been surveying the environmental radiation status after the disaster in response to numerous requests from its citizens. The radiation surveillance in this area has been technically guided by radiation protection specialists. The two main targets for surveillance are (1) the ambient radiation dose (microsieverts per hour) at all the school yards, public parks, and representative measurement points selected by the local government, and (2) the specific radioactivity (becquerels per kilogram) present in school lunch. These data have been reported to the citizens through the city website as well as in a bi-monthly report in the public relations magazine of the local government. This report presents the background status and technical information of the related activities, as well as the measured environmental radiation data. The ambient radiation dose in the city has been surveyed since July 2011. In the 1st period of surveillance (from July to August, 2012), over a total of 304 measurement points, the highest recorded value of the ambient radiation dose was 0.22 μSv h"-"1 at the height of 1 m from the ground, the lowest was 0.05 μSv h"-"1, and the average was around 0.09 μSv h"-"1. These values include the natural background dose rate detected by the energy compensation type surveymeters. In the most recent surveillance records, the maximum value recorded was 0.10, the minimum was 0.05, and 0.07 μSv h"-"1 was the average value. The specific radioactivity of drinking water has been monitored at local purification plants since the accident occurred. No water sample supplied to the city has exceeded the national limits for intake dose. The specific radioactivity of school lunch was

  19. Reduction of intergranular exchange coupling and grain size for high Ku CoPt-based granular media: Metal-oxide buffer layer and multiple oxide boundary materials

    Directory of Open Access Journals (Sweden)

    Kim Kong Tham

    2018-05-01

    Full Text Available Investigation of magnetic properties and microstructure of granular media with various multiple oxides as the grain boundary material is reported. Saturation magnetization (Ms, uniaxial magnetocrystalline anisotropy (Ku, and magnetic grain diameter (GD of the granular media show linear correlation with volume weighted average for melting point (Tm of each oxides (Tmave. Ku of magnetic grains (Kugrain shows a trade-off relation with GD that it is a big challenge to satisfy both high Kugrain and small GD by only controlling Tmave. To obtain a granular medium with appropriate Kugrain, GD, and low degree of intergranular exchange coupling, the combination of Tmave control of grain boundary material by mixing oxides and employment of a buffer layer are required. Here the degree of intergranular exchange coupling is estimated from the slope of M-H loop at around coercivity (α. By applying this technique, a typical granular medium with Kugrain of 1.0×107 erg/cm3, GD of 5.1 nm, and α of 1.2 is realized.

  20. Waldenström's macroglobulinemia harbors a unique proteome where Ku70 is severely underexpressed as compared with other B-lymphoproliferative disorders

    International Nuclear Information System (INIS)

    Perrot, A; Pionneau, C; Azar, N; Baillou, C; Lemoine, F M; Leblond, V; Merle-Béral, H; Béné, M-C; Herbrecht, R; Bahram, S; Vallat, L

    2012-01-01

    Waldenström's macroglobulinemia (WM) is a clonal B-cell lymphoproliferative disorder (LPD) of post-germinal center nature. Despite the fact that the precise molecular pathway(s) leading to WM remain(s) to be elucidated, a hallmark of the disease is the absence of the immunoglobulin heavy chain class switch recombination. Using two-dimensional gel electrophoresis, we compared proteomic profiles of WM cells with that of other LPDs. We were able to demonstrate that WM constitutes a unique proteomic entity as compared with chronic lymphocytic leukemia and marginal zone lymphoma. Statistical comparisons of protein expression levels revealed that a few proteins are distinctly expressed in WM in comparison with other LPDs. In particular we observed a major downregulation of the double strand repair protein Ku70 (XRCC6); confirmed at both the protein and RNA levels in an independent cohort of patients. Hence, we define a distinctive proteomic profile for WM where the downregulation of Ku70—a component of the non homologous end-joining pathway—might be relevant in disease pathophysiology

  1. USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis

    Directory of Open Access Journals (Sweden)

    Aman Wang

    2017-05-01

    Full Text Available Resistance to platinum-based chemotherapy is one of the most important reasons for treatment failure in advanced non-small cell lung cancer, but the underlying mechanism is extremely complex and unclear. The present study aimed to investigate the correlation of ubiquitin-specific peptidase 22 (USP22 with acquired resistance to cisplatin in lung adenocarcinoma. In this study, we found that overexpression of USP22 could lead to cisplatin resistance in A549 cells. USP22 and its downstream proteins γH2AX and Sirt1 levels are upregulated in the cisplatin- resistant A549/CDDP cell line. USP22 enhances DNA damage repair and induce cisplatin resistance by promoting the phosphorylation of histone H2AX via deubiquitinating histone H2A. In addition, USP22 decreases the acetylation of Ku70 by stabilizing Sirt1, thus inhibiting Bax-mediated apoptosis and inducing cisplatin resistance. The cisplatin sensitivity in cisplatin-resistant A549/CDDP cells was restored by USP22 inhibition in vivo and vitro. In summary, our findings reveal the dual mechanism of USP22 involvement in cisplatin resistance that USP22 can regulate γH2AX-mediated DNA damage repair and Ku70/Bax-mediated apoptosis. USP22 is a potential target in cisplatin-resistant lung adenocarcinoma and should be considered in future therapeutic practice.

  2. Focusing electrode and coaxial reflector used for reducing the guiding magnetic field of the Ku-band foilless transit-time oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Ling, Junpu; Zhang, Jiande; He, Juntao, E-mail: hejuntao12@163.com; Wang, Lei; Deng, Bingfang [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-08-15

    Based on the theoretical analysis of the intense relativistic electron beam propagation in the coaxial drift-tube, a focusing electrode and a coaxial reflector is proposed to lessen the demand of the coaxial Ku-band foilless transit-time oscillator (TTO) for the guiding magnetic field. Moreover, a Ku-band TTO with the focusing electrode and the coaxial reflector is designed and studied by particle in cell simulation. When the diode voltage is 390 kV, the beam current 7.8 kA, and the guiding magnetic field is only 0.3 T, the device can output 820 MW microwave pulse at 14.25 GHz by means of the simulation. However, for the device without them, the output power is only 320 MW. The primary experiments are also carried out. When the guiding magnetic field is 0.3 T, the output power of the device with the focusing electrode and the coaxial reflector is double that of the one without them. The simulation and experimental results prove that the focusing electrode and the coaxial reflector are effective on reducing the guiding magnetic field of the device.

  3. Reduction of intergranular exchange coupling and grain size for high Ku CoPt-based granular media: Metal-oxide buffer layer and multiple oxide boundary materials

    Science.gov (United States)

    Tham, Kim Kong; Kushibiki, Ryosuke; Kamada, Tomonari; Hinata, Shintaro; Saito, Shin

    2018-05-01

    Investigation of magnetic properties and microstructure of granular media with various multiple oxides as the grain boundary material is reported. Saturation magnetization (Ms), uniaxial magnetocrystalline anisotropy (Ku), and magnetic grain diameter (GD) of the granular media show linear correlation with volume weighted average for melting point (Tm) of each oxides (Tmave). Ku of magnetic grains (Kugrain) shows a trade-off relation with GD that it is a big challenge to satisfy both high Kugrain and small GD by only controlling Tmave. To obtain a granular medium with appropriate Kugrain, GD, and low degree of intergranular exchange coupling, the combination of Tmave control of grain boundary material by mixing oxides and employment of a buffer layer are required. Here the degree of intergranular exchange coupling is estimated from the slope of M-H loop at around coercivity (α). By applying this technique, a typical granular medium with Kugrain of 1.0×107 erg/cm3, GD of 5.1 nm, and α of 1.2 is realized.

  4. KU24 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  5. Ku dydaktyce afirmatywnej

    Directory of Open Access Journals (Sweden)

    Monika Rogowska-Stangret

    2016-11-01

    Full Text Available "Towards affirmative didactics" The article “Towards affirmative didactics” is a description of a project reflecting on the experience of teaching and learning in a systematic and complex manner. It is also an effort to define the conditions that could encourage values such as inclusiveness, tolerance, mindfulness, joint responsibility, as well as engagement in and support for actions undertaken to strengthen the above-mentioned values. The project is a work in progress and it consists of two parts. The first one is critical and it describes the given situation by pointing the main threats involved. The second – affirmative one – was created with the effort to develop positive guidelines that would encourage transformations in the approach to didactics.

  6. Volcanology of Tuzo pipe (Gahcho Kué cluster) — Root-diatreme processes re-interpreted

    Science.gov (United States)

    Seghedi, I.; Maicher, D.; Kurszlaukis, S.

    2009-11-01

    The Middle Cambrian (~ 540 Ma) Gahcho Kué Kimberlite Field is situated about 275 km ENE of Yellowknife, NWT, Canada. The kimberlites were emplaced into 2.6 Ga Archean granitic rocks of the Yellowknife Supergroup. Four larger kimberlite bodies (5034, Tesla, Tuzo, and Hearne) as well as a number of smaller pipes and associated sheets occur in the field. In plan view, the Tuzo pipe has a circular outline at the surface, and it widens towards deeper levels. The pipe infill consists of several types of coherent and fragmental kimberlite facies. Coherent or apparent coherent (possibly welded) kimberlite facies dominate at depth, but also occur at shallow levels, as dikes intruded late in the eruptive sequence or individual coherent kimberlite clasts. The central and shallower portions of the pipe consist of several fragmental kimberlite varieties that are texturally classified as Tuffisitic Kimberlites. The definition, geometry and extent of the geological units are complex and zones controlled by vertical elements are most significant. The fluidal outlines of some of the coherent kimberlite clasts suggest that at least some are the product of disruption of magma that was in a semi-plastic state or even of welded material. Ragged clasts at low levels are inferred to form part of a complex peperite-like system that intrudes the base of the root zone. A variable, often high abundance of local wall-rock xenoliths between and within the kimberlite phases is observed, varying in size from sub-millimeter to several tens of meters. Wall-rock fragments are common at all locations within the pipe but are especially frequent in a domain with a belt-like geometry between 120 and 200 m depth in the pipe. Steeply outward-dipping bedded deposits made up of wall-rock fragments occur in deep levels of the pipe and are especially common under the downward-widening roof segments. The gradational contact relationships of these deposits with the surrounding kimberlite-bearing rocks as well

  7. Generation, Transformation and Place in Inga Iwasiów’s Novels Bambino (2008 and Ku słońcu (2010

    Directory of Open Access Journals (Sweden)

    Ursula PHILLIPS

    2012-06-01

    Full Text Available This chapter will discuss two novels by contemporary writer Inga Iwasiów (b. 1963, Bambino (2008 and Ku słońcu [Towards the Sun] (2010, in the context of geopolitical, ideological, social and psycho-cultural transformations as they specifically affect different generations of inhabitants of the Polish city of Szczecin (pre-1945 German Stettin from 1945 until the first decade of the 21st century. Bambino covers the years 1945–1981, but also contains flashbacksto pre-war memory of Stettin and to the suppressed experiences of the new post-war inhabitants, as well as ‘flash-forwards’ to post-1989, post-communist reality; Ku słońcu covers 1981 to the first decade of 2000s. It will show how the novels portray these transformations through the experience primarily of women (but not only — in Bambino, through the main protagonists: Ula (formerly Ulrike, Anna and Marysia, and through that of the hidden narrator Magda (Marysia’s daughter born in the same year as the author, Iwasiów, 1963; and in Ku słońcu, primarily through the experience of Magda herself, as well as through that of two generations of ‘feminist’ academics: Małgorzata and Sylwia (in which it is hard not to perceive the personal experience of the author, though she is at pains to emphasize elsewhere that her work is a collective biography of the city, not so much of herself. The analysis follows Katarzyna Chmielewska’s supposition that contemporary Polish fiction dealing with the past ‘constantly oscillates between memory and genealogy’, and that it raises raw issues not yet addressed by historians; it also derives inspiration from the new ‘postdependency’ studiesproposed by Hanna Gosk and Ryszard Nycz. It also attempts to capture the specific nature of Iwasiów’s use of language, her style of feminism, her method of portraying place, and the connections in her prose between place and memory.

  8. Vecāku audzināšanas stila saistība ar pusaudžu vientulības izjūtu

    OpenAIRE

    Vlasova, Iveta

    2013-01-01

    Pētījuma jautājums: Vai starp mātes audzināšanas stilu un vientulības līmeni pusaudžiem pastāv saistība? Pētījuma dalībnieki. Viena izlase, pēc pieejamības principa. Dalībnieku vecums: 12-16 gadi, 31 meitene, 23 zēni. Dzīvojoši pilnās ģimenēs. Pētījuma metode. 1.Lieto, lai noteiktu kopējo vientulības izjūtas līmeni, tika izmantota Vientulības skala (UCLA Loneliness Scale/UCLA LS/, VERSION 3; Russel, D.W. 1996).– visu jautājumu summa. 2.Vecāku audzināšanas stila aptauja (Parental...

  9. Vecāku audzināšanas stilu saistība ar pašcieņu pusaudžu vecumā

    OpenAIRE

    Miķelsone-Ježaka, Dace

    2008-01-01

    Darba mērķis ir izpētīt pašcieņas saistību ar mātes un tēvu audzināšanas stilu bērnībā. Pētījumā piedalījās 105 pusaudži no dažādām skolām vecumā no 16 līdz 18 gadiem, kas dzīvo pilnās ģimenēs. Tika izmantotas 2 aptaujas: 1. Vecāku autoritātes novērtējuma aptauja (The Parental Authority Questionnaire, Buri, 1991; Griškina, 2002). 2. Rozenberga pašcieņas aptauja (The Rosenberg Self – esteem Scale, Rosenberg, 1965).

  10. Motorické projevy laterality u osob středního věku a starších

    OpenAIRE

    Habartová, Lucie

    2008-01-01

    Název dielomové eráce: Motorické projevy laterality u osob středního věku a starších. Název v gnglickém jazyce: The Manifestations of Motoric Laterality of Middle-aged People and Elderly. Cíle eráce: Definovat, popsat lateralitu, zjistit stupeň laterality horní končetiny, dolní končetiny a oka. Zjistit vztah laterality horních končetin a očí, horních končetin a dolních končetin. Metoda: Lateralitu budeme zjišťovat na základě dotazníků a motorických testů. Testovaný soubor čítá 50 probandů ve ...

  11. Wpływ wysiłku fizycznego na funkcję układu oddechowego w twardzinie układowej

    OpenAIRE

    Stanisław Sierakowski; Ewa Gińdzieńska-Sieśkiewicz; Maciej Kaczmarski; Zenon Siergiejko; Grzegorz Siergiejko; Piotr Siergiejko; Justyna Fryc

    2010-01-01

    Cel: Powikłania ze strony układu oddechowego stanowią główną przyczynę zgonów pacjentów z twardziną układową (TU). Tętniczenadciśnienie płucne i śródmiąższowa choroba płuc stanowią najistotniejszez nich. Pacjenci są jednak często zdiagnozowani dopierow późnym okresie choroby, dlatego też istotne jest opracowaniemetody diagnostycznej do wczesnego wykrywania tych powikłań.Celem pracy była ocena wpływu wysiłku fizycznego na zmiany parametrówoddechowych. Materiały i metody: Badania przeprowadzono...

  12. A Novel Ku-Band/Ka-Band and Ka-Band/E-Band Multimode Waveguide Couplers for Power Measurement of Traveling-Wave Tube Amplifier Harmonic Frequencies

    Science.gov (United States)

    Wintucky, Edwin G.; Simons, Rainee N.

    2015-01-01

    This paper presents the design, fabrication and test results for a novel waveguide multimode directional coupler (MDC). The coupler, fabricated from two dissimilar frequency band waveguides, is capable of isolating power at the second harmonic frequency from the fundamental power at the output port of a traveling-wave tube (TWT) amplifier. Test results from proof-of-concept demonstrations are presented for a Ku-band/Ka-band MDC and a Ka-band/E-band MDC. In addition to power measurements at harmonic frequencies, a potential application of the MDC is in the design of a satellite borne beacon source for atmospheric propagation studies at millimeter-wave (mm-wave) frequencies (Ka-band and E-band).

  13. Y Kuşağının Mobil Öğrenme Uygulama Tercihini Etkileyen Faktörlerin İncelenmesi

    OpenAIRE

    ALTUNTAŞ, Başar

    2017-01-01

    Mobilteknolojilerin öğrenme ortamlarına dâhil edilmesiyle birlikte öğrenme faaliyetifiziksel sınırların dışına çıkmış ve farklı bir boyuta evrilmiştir. Tasarlanan öğrenmeuygulamaları kullanıcılarına zamandan ve mekândan bağımsız öğrenme fırsatısunarken, yeni ve farklı deneyimleri de beraberinde getirmiştir. Bu çalışmada,Y kuşağının mobil öğrenme uygulamalarını tercih etmesini ve kullanmasınıetkileyen faktörler incelenmiştir. Teknoloji kabul modeli ile beklenti-kabul modelitemelinde tasarlanan...

  14. From Resident to President: The Sinuous Participation of Paraguayan Women in Politics and the Emergence of the Feminist Political Movement Kuña Pyrenda

    Directory of Open Access Journals (Sweden)

    Sarah Cerna Villarga

    2015-07-01

    Full Text Available Paraguayan women have transcended history as the mothers of the “Guarani breed”, as The Resident Woman Residentas, the social role of these has been undeniable, but in other scopes, such as the political area, its social and historical role is still invisible, because the policy has historically been considered a male activity. However, many women have contributed to the construction of the history of this nation, and although the asymmetries in the real access to power between men and women are notorious today, Paraguayan want power and will seek, as it was found in the last two presidential elections of 2008 and 2013. On this basis, this paper aims to describe what has been the impact of feminism in Paraguayan politics and, in turn, explain the factors that have influenced raid Kuña Pyrenda feminist movement in the elections of 2013.

  15. Kinetics of destruction of KU-2 x 8 and AV-17 x 8 ion-exchange resins by the joint action of heating and irradiation

    International Nuclear Information System (INIS)

    Tulupov, P.E.; Butenko, T.Yu.

    1982-01-01

    Experimental data indicates a decrease of the exchange capacity of AV-17 x 8 (OH) resin in ion-exchange beds at various temperatures. Losses of exchange of the resin in hydroxyl form after 10,000h of continuous heating at 60, 70, and 80 0 C are 24, 44, and 78% respectively. Partial replacement of the hydroxyl by the salt form is accomplished by appreciable lowering of capacity losses. The trimethlyamine evolved during deamination of AV-17 x 8 anion exchange resin, and only methanol, enters the coolant. Under the influence of ionizing radiation in the active zone the methanol will be converted successively into formaldehyde, formic acid and CO 2 . Thus the maximum temperature of use of the hydroxyl form of te anion-exchange resin AV-17 x 8 (OH) in nuclear power plants can be raised to 70-75 0 C. Brief changes of temperature at 100 0 C do not cause any appreciable losses of exchange capacity either. Physicochemical properties of ion-exchange resins after use in nuclear power plants leads to excessive and unjustified restriction of their service life in the course of a single cycle. Joint action of heating and irradiation on AV-17 anion-exchange resin was studied. It was found that rate constants of the processes of thermal radiation decreases the exchange capacities of the resins in the temperature ranges of interest with relation to nuclear power plants. Calculation of the stability of KU-2 x 8 cation-exchange resin shows that even after a year of use at 100 0 C the loss of its exchange capacity is less than 0.1%. Therefore, under the conditions of use in a nuclear power plant KU-2 x 8 resin can be regarded as absolutely stable. The loss of exchange capacity of AV-17 x 8 resin in C1 form at 100 0 C is of similar magnitude

  16. Room Temperature Thin Film Ba(x)Sr(1-x)TiO3 Ku-Band Coupled MicrostripPhase Shifters: Effects of Film Thickness, Doping, Annealing and Substrate Choice

    Science.gov (United States)

    VanKeuls, F. W.; Mueller, C. H.; Miranda, F. A.; Romanofsky, R. R.; Canedy, C. L.; Aggarwal, S.; Venkatesan, T.; Ramesh, R.; Horwitz, S.; Chang, W.

    1999-01-01

    We report on measurements taken on over twenty Ku-band coupled microstrip phase shifters (CMPS) using thin ferroelectric films of Ba(x)Sr(1-x)TiO3. This CMPS design is a recent innovation designed to take advantage of the high tunability and tolerate the high dielectric constant of ferroelectric films at Ku- and K-band frequencies. These devices are envisioned as a component in low-cost steerable beam phased area antennas, Comparisons are made between devices with differing film thickness, annealed vs unannealed, Mn-doped vs. undoped, and also substrates of LaAlO3 and MgO. A comparison between the CMPS structure and a CPW phase shifter was also made oil the same ferroelectric film.

  17. Emocionālā intelekta attīstība 16 -18 gadus veciem pusaudžiem un tā saistība ar vecāku audzināšanas stilu.

    OpenAIRE

    Poļakova, Anželika

    2011-01-01

    Šī pētījuma mērķis ir noskaidrot, vai vecāku izvēlētais audzināšanas stils ir saistīts ar emocionālā intelekta attīstību. Pētījumā piedalījās 64 respondenti: 32 sievietes no 16 līdz 18 gadiem un 32 vīrieši no 16 līdz 18 gadiem. Respondenti pārstāv dažādas sociāli ekonomiskas grupas. Tika izmantotas šādas metodes: Bar-Ona emocionālā intelekta aptauja (Bar-On Emotional Quotient Inventory (EQ-i), Bar-On, 1999) un Buri Vecāku audzināšanas stila aptauju (Buri Parental Authority Questionnaire- PAQ...

  18. Microwave absorption in X and Ku band frequency of cotton fabric coated with Ni–Zn ferrite and carbon formulation in polyurethane matrix

    International Nuclear Information System (INIS)

    Gupta, K.K.; Abbas, S.M.; Goswami, T.H.; Abhyankar, A.C.

    2014-01-01

    The present study highlights various microwave properties, i.e. reflection, transmission, absorption and reflection loss, of the coated cotton fabric [formulation: Ni–Zn ferrite (Ni 0.5 Zn 0.5 Fe 2 O 4 ) and carbon black (acetylene black) at concentrations of 30, 40, 50, 60 and70 g of ferrite and 5 g carbon in each 100 ml polyurethane] evaluated at 8–18 GHz frequency. The uniform density of filling materials in coated fabrics (dotted marks in SEM micrograph) indicates homogeneous dispersion of conducting fillers in polyurethane and the density of filling material cluster increases with increase in ferrite concentration. SEM images also show uniform coating of conducting fillers/resin system over individual fibers and interweave spaces. The important parameters governing the microwave properties of coated fabrics i.e. permittivity and permeability, S-parameters, reflection loss, etc. were studied in a HVS free space microwave measurement system. The lossy character of coated fabric is found to increase with increase of ferrite content; the ferrite content decreases the impedance and increases the permittivity and permeability values. The 1.6–1.8 mm thick coated fabric sample (40 wt% ferrite, 3 wt% carbon and 57 wt% PU) has shown about 40% absorption, 20% transmission and 40% reflectance in X (8.2–12.4 GHz) and Ku (12–18 GHz) frequency bands. The reflection loss at 13.5 GHz has shown the highest peak value (22.5 dB) due to coated sample optical thickness equal to λ/4 and more than 7.5 dB in entire Ku band. Owing to its thin and flexible nature, the coated fabric can be used as apparel in protecting human being from hazardous microwaves and also as radar camouflage covering screen in defense. - Highlights: • Ni–Zn ferrite (Ni 0.5 Zn 0.5 Fe 2 O 4 ) with acetylene black found effective coating for microwave absorption. • Coating formulation containing 40 wt% ferrite, 3 wt% carbon and 57 wt% PU offered 40% absorption, 20% transmission and 40% reflection

  19. Microwave absorption in X and Ku band frequency of cotton fabric coated with Ni–Zn ferrite and carbon formulation in polyurethane matrix

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, K.K., E-mail: krishna62@rediffmail.com [Defence Materials and Stores Research and Development Establishment, Kanpur PO, GT Road, Kanpur 208013 (India); Abbas, S.M.; Goswami, T.H. [Defence Materials and Stores Research and Development Establishment, Kanpur PO, GT Road, Kanpur 208013 (India); Abhyankar, A.C. [Defence Institute of Advanced Technology( DIAT), Giri Nagar, Pune 411025 (India)

    2014-08-01

    The present study highlights various microwave properties, i.e. reflection, transmission, absorption and reflection loss, of the coated cotton fabric [formulation: Ni–Zn ferrite (Ni {sub 0.5}Zn{sub 0.5}Fe{sub 2}O{sub 4}) and carbon black (acetylene black) at concentrations of 30, 40, 50, 60 and70 g of ferrite and 5 g carbon in each 100 ml polyurethane] evaluated at 8–18 GHz frequency. The uniform density of filling materials in coated fabrics (dotted marks in SEM micrograph) indicates homogeneous dispersion of conducting fillers in polyurethane and the density of filling material cluster increases with increase in ferrite concentration. SEM images also show uniform coating of conducting fillers/resin system over individual fibers and interweave spaces. The important parameters governing the microwave properties of coated fabrics i.e. permittivity and permeability, S-parameters, reflection loss, etc. were studied in a HVS free space microwave measurement system. The lossy character of coated fabric is found to increase with increase of ferrite content; the ferrite content decreases the impedance and increases the permittivity and permeability values. The 1.6–1.8 mm thick coated fabric sample (40 wt% ferrite, 3 wt% carbon and 57 wt% PU) has shown about 40% absorption, 20% transmission and 40% reflectance in X (8.2–12.4 GHz) and Ku (12–18 GHz) frequency bands. The reflection loss at 13.5 GHz has shown the highest peak value (22.5 dB) due to coated sample optical thickness equal to λ/4 and more than 7.5 dB in entire Ku band. Owing to its thin and flexible nature, the coated fabric can be used as apparel in protecting human being from hazardous microwaves and also as radar camouflage covering screen in defense. - Highlights: • Ni–Zn ferrite (Ni{sub 0.5}Zn{sub 0.5}Fe{sub 2}O{sub 4}) with acetylene black found effective coating for microwave absorption. • Coating formulation containing 40 wt% ferrite, 3 wt% carbon and 57 wt% PU offered 40% absorption, 20

  20. The determinants of long-term care utilization and equity of access to care among older adults in Dong-Ku of Incheon Metropolitan city, South Korea.

    Science.gov (United States)

    Park, J M

    2005-01-01

    Under the current health care system, around three percent of the elderly remain uninsured. Based on the 2003 Dong-Ku Health Status Survey and the Aday and Andersen Access Framework, the present study examined the social and behavioral determinants of long-term care utilization and the extent to which equity in the use of long-term care services for the elderly has been achieved. The results indicate that universal health insurance system has not yielded a fully equitable distribution of services. Type of coverage and resource availability do not remain predictors of long-term care utilization. The data suggest that a universal health insurance system exists in South Korea with significant access problems for the population without insurance. Access differences also arise from obstacles in expanding the scope and level of plan benefits due to financial disparity among insurers. Health policy reforms must continue to concentrate on extending insurance coverage to the uninsured and establishing long-term insurance system for the elderly.

  1. Multi-Satellite MIMO Communications at Ku-Band and Above: Investigations on Spatial Multiplexing for Capacity Improvement and Selection Diversity for Interference Mitigation

    Directory of Open Access Journals (Sweden)

    Liolis Konstantinos P

    2007-01-01

    Full Text Available This paper investigates the applicability of multiple-input multiple-output (MIMO technology to satellite communications at the Ku-band and above. After introducing the possible diversity sources to form a MIMO matrix channel in a satellite environment, particular emphasis is put on satellite diversity. Two specific different topics from the field of MIMO technology applications to satellite communications at these frequencies are further analyzed: (i capacity improvement achieved by MIMO spatial multiplexing systems and (ii interference mitigation achieved by MIMO diversity systems employing receive antenna selection. In the first case, a single-user capacity analysis of a satellite MIMO spatial multiplexing system is presented and a useful analytical closed form expression is derived for the outage capacity achieved. In the second case, a satellite MIMO diversity system with receive antenna selection is considered, adjacent satellite cochannel interference on its forward link is studied and an analytical model predicting the interference mitigation achieved is presented. In both cases, an appropriate physical MIMO channel model is assumed which takes into account the propagation phenomena related to the frequencies of interest, such as clear line-of-sight operation, high antenna directivity, the effect of rain fading, and the slant path lengths difference. Useful numerical results obtained through the analytical expressions derived are presented to compare the performance of multi-satellite MIMO systems to relevant single-input single-output (SISO ones.

  2. Functional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIVmac251- or simian-human immunodeficiency virus KU2-infected macaques

    International Nuclear Information System (INIS)

    Stevceva, Liljana; Moniuszko, Marcin; Alvarez, Xavier; Lackner, Andrew A.; Franchini, Genoveffa

    2004-01-01

    The vaginal and rectal mucosae are the first line of cellular immune defense to sexually transmitted human immunodeficiency virus type 1 (HIV-1) entry. Thus, intraepithelial lymphocytes (IELs) may be important in the immune response to HIV infection. Here we investigated whether functional IELs in mucosal compartments could be visualized by direct staining with a tetrameric complex specific for the simian immunodeficiency virus (SIV) immunodominant Gag epitope in either separated IEL cells or tissues of macaques infected with SIVmac251. Of the 15 Mamu-A*01-positive macaques studied here, eight were chronically infected with either SIVmac251 or simian-human immunodeficiency virus (SHIV) KU2 and the remaining seven were exposed mucosally to SIVmac251 and sacrificed within 48 h to assess the local immune response. Gag-specific CD8+ T-cells were found in separated IELs from the rectum, colon, jejunum, and vagina of most infected animals. Direct staining of tetramers also revealed their presence in intact tissue. These Gag-specific IELs expressed the activation marker CD69 and produced IFN-γ, suggesting an active immune response in this locale

  3. Problemas de los grupos *k(hi̭, *kṷ(hi̭, *t(hi̭ y *tṷ en griego

    Directory of Open Access Journals (Sweden)

    M.ª Luisa del Barrio Vega

    1990-12-01

    Full Text Available In this research the author studies a series of problems related to the evolution of the groups *k(hi̭, *kṷ(hi̭, *t(hi̭ and *tṷ in Greek. After a brief description of the palatalization process undergone by these groups and considering the different results from *t(hi̭ in the Ionic-Attic and Arcadian-Cypriot dialects which were swept twice by a wave of palatalization as well as the possible influence by analogy of the development undergone by *k(hi̭, the author examines in great depth the state of these groups at the time of the Mycenaean tablets analyzing the different values proposed for the series z- and s-. For z- an occlusive palatal and for s- an affricate articulation are considered the most likely ones. The author further suggests that the s- series followed an evolution parallel to that of the complex syllabograms of the type raz, roz, etc. Subsequently the author analyzes the graphic issues related to the evolution of the phonemic groups under study: The use of a special graphical notation in some Ionic and Pamphylian σσ/ττ in the dialects during the first millennium are due to the influence derived from the graphic representation of the state *ts. Finally the author suggests the Boeotian dialect as a starting point for the change *ts > tt, as in this dialect tt has a corresponding voiced series dd.

  4. Pusaudžu agresivitātes saistība ar vecāku audzināšanas stilu.

    OpenAIRE

    Dambe, Agnese

    2007-01-01

    Šajā darbā tiek apskatīta viena no mūsdienu būtiskākajām problēmām- pusaudžu agresivitāte. Pētījuma mērķis bija noskaidrot, vai pastāv statistiski nozīmīgas saistības starp vecāku audzināšanas stilu un pusaudžu agresivitāti. Pētījuma izlasi veido 60 pusaudži (30 jaunietes un 30 jaunieši) no pilnām ģimenēm, vecumposmā no 15-17 gadiem. Pētījumā tika izmantotas divas pētījuma metodes- A.H. Bassa (A.H. Buss)- A. Darki (A. Durkee) aptaujas anketa agresīvu reakciju noteikšanai un ...

  5. Pusaudžu tipiskās reakcijas pēc vecāku laulības šķiršanas.

    OpenAIRE

    Steļmaha, Elza

    2011-01-01

    Rezumējums Pētījuma „Pusaudžu depresija un uzvedības problēmas pēc vecāku laulības šķiršanas” mērķis bija noskaidrot kādas ir pusaudžu uzvedības un depresijas atšķirības starp šķirtajām un pilnajām ģimenēm.. Pētījuma papildus daļas mērķis bija noskaidrot kādas ir atšķirības depresijas izpausmēm un uzvedības problēmām, meitenēm un zēniem gan šķirto, gan pilno ģimeņu izlasē. Pētījumā piedalījās 60 respondenti vecuma grupā no 13-16 gadiem, 30 pusaudžiem vecāki ir šķiršanās procesā vai šķīr...

  6. Ku to V-band 4-bit MEMS phase shifter bank using high isolation SP4T switches and DMTL structures

    Science.gov (United States)

    Dey, Sukomal; Koul, Shiban K.; Poddar, Ajay K.; Rohde, Ulrich L.

    2017-10-01

    This work presents a micro-electro-mechanical system (MEMS) based on a wide-band 4-bit phase shifter using two back-to-back single-pole-four-throw (SP4T) switches and four different distributed MEMS transmission line (DMTL) structures that are implemented on 635 µm alumina substrate using surface micromachining process. An SP4T switch is designed with a series-shunt configuration and it demonstrates an average return loss of  >17 dB, an insertion loss of  28 dB up to 60 GHz. A maximum area of the SP4T switch is ~0.76 mm2. Single-pole-single-throw and SP4T switches are capable of handling 1 W of radio frequency (RF) power up to  >100 million cycles at 25° C; they can even sustained up to  >70 million cycles with 1 W at 85 °C. The proposed wide-band phase shifter works at 17 GHz (Ku-band), 25 GHz (K-band), 35 GHz (Ka-band) and 60 GHz (V-band) frequencies. Finally,a 4-bit phase shifter demonstrates an average insertion loss of  10 dB and maximum phase error of ~3.8° at 60 GHz frequency over 500 MHz bandwidth. Total area of the fabricated device is ~11 mm2. In addition, the proposed device works well up to  >107 cycles with 1 W of RF power. To the best of the author’s knowledge, this is the best reported wide-band MEMS 4-bit phase shifter in the literature that works with a constant resolution.

  7. Endothelin-A-receptor antagonism with atrasentan exhibits limited activity on the KU-19-19 bladder cancer cell line in a mouse model.

    Science.gov (United States)

    Herrmann, Edwin; Tiemann, Arne; Eltze, Elke; Bolenz, Christian; Bremer, Christoph; Persigehl, Thorsten; Hertle, Lothar; Wülfing, Christian

    2009-10-01

    The endothelin axis consists of endothelin-1 (ET-1) and its two receptors, ET(A)- and ET(B)-receptor (ET(A)-R and ET(B)-R). In several tumor entities, the ET(A)-R plays a significant role as a drug target. In our study, we investigated whether inhibition of ET(A)-R with atrasentan leads to an antitumor effect in urinary bladder carcinoma as well. Twenty nude mice with thymic aplasia were subcutaneously administered 2 x 10(6) KU-19-19 bladder cancer cells in the right flank. Starting on the 22nd day after the injection, ten animals were treated with atrasentan (2.5 mg/kg BW intraperitoneally), and another ten animals were treated with placebo. During treatment, absolute tumor growth and relative growth rate over time were determined. After the end of treatment, the mitosis and necrosis rates, microvessel density, and receptor density in the tumor tissue were analyzed by immunohistochemistry. In addition, the expression intensities of ET-1, ET(A)-R, and ET(B)-R were evaluated semiquantitatively and compared between the groups. No significant differences between the active-treatment and placebo groups were detected, either with respect to absolute tumor growth (P = 0.333) or mitosis rate (P = 0.217). In the analysis of the necrosis rate and receptor density for ET(A)-R, a trend toward higher values in the active-treatment group (mean necrosis rate = 63.67%, receptor density: 1.417) than in the placebo group (mean necrosis rate = 46.25%, receptor density: 1.270) was found; however, neither difference was statistically significant (P = 0.08 and 0.219, respectively). ET(A)-R blockade with atrasentan in a bladder cancer xenograft model shows no significant antitumor effect.

  8. Use of combined ion exchangers on the basis of KU-23 and KM-2p cation exchangers for purification of ammonium molybdate and tungstate solutions from phosphate, arsenate, and silicate impurities

    International Nuclear Information System (INIS)

    Blokhin, A.A.; Majorov, D.Yu.; Kopyrin, A.A.; Taushkanov, V.P.

    2002-01-01

    Using the Tracer technique ( 32 P) and elementary analysis, potentiality of using combined ionites on the basis of macroporous cation-exchange resins KU-23 or KM-2p and hydrated zirconium oxide for purification of concentrated solutions of ammonium molybdate and tungstate from phosphate-, arsenate-, and silicate-ions impurities was studied. High selectivity of the combined ionites towards impurity ions was ascertained, which permits reducing the content of impurities by a factor of 50-100 compared with the initial one [ru

  9. Archaeological investigations in medieval Viljandi the castle and its surroundings / Arvi Haak, Riina Juurik

    Index Scriptorium Estoniae

    Haak, Arvi

    2007-01-01

    Kaevamistest ordulinnuses, uuringutest III eeslinnusel (Esimesel Kirsimäel) peavärava piirkonnas, järelevalvetöödest linnusest lääne poole jääval alal, uuringutest Tartu tänav 28A ja 30 kruntidel. Keraamikaleidude põhjal tekkis asustus Tartu tänav 30 piirkonnas 14. sajandi teisel poolel või veelgi varem

  10. Vana platelsitsija juhtum: kapo töö kogemustepagas / Arvi Tap-Tapver

    Index Scriptorium Estoniae

    Tap-Tapver, Arvi

    2009-01-01

    Eesti Kaitsepolitsei uuris 1990-ndatel tollase Koonderakonna juhi ja Riigikogu riigikaitsekomisjoni esimehe Peeter Lorentsi seotust Soomest relvade salakaubana sissetoomisega mässulisele Läänemaa Vabatahtlike Jäägrikompaniile 1993. a., vahetult enne Pullapää kriisi

  11. Tri gorsti za Tsentralnõi rõnok / Arvi Tapver

    Index Scriptorium Estoniae

    Tapver, Arvi

    1999-01-01

    Mõrvatud endise abilinnapea Mait Metsamaa keskturu erastajatest kaaskond kahlustas tunnistaja sõnul topeltmängu, kui Metsamaa vanale sõbrale ja allilmas kardetavale Meelis Laole erastamisest loobumise eest hüvitist pakkus

  12. Tööhõive probleemid Eestis / Arvi Altmäe

    Index Scriptorium Estoniae

    Altmäe, Arvi, 1942-

    2003-01-01

    Ilmunud ka: Tallinna Tehnikakõrgkooli Toimetised nr. 3, Tallinn, 2003, lk. 22-25. Autori arvates on töötuse, hariduse ja väljarände probleemid selgelt regionaalpoliitilised, samas on tööhõive probleemid hajutatud erinevate ministeeriumide haldusalades ning ei ole seetõttu tõusnud tähelepanu keskmesse. Tabelid

  13. ETIOPATHOGENETIC TREATMENT OF INFLUENZA AND ARVI IN CHILDREN: A NEW LOOK AT THE OLD PROBLEM

    Directory of Open Access Journals (Sweden)

    O. V. Shamsheva

    2017-01-01

    Full Text Available A new value was acquired by the drug Orvirem®, which is a combination of rimantadine and natrium alginate. In recent years, it has not been recommended for use due to the resistance to it strains of the influenza A(H1N1 virus pdm2009. Currently, this drug has acquired a new meaning, and this is due to the dominance of subtype A(H3N2. Two recent clinical studies have demonstrated that the drug Orvirem® has proven activity against viruses not only of influenza A but also B, coronavirus, and other common pathogens of respiratory viral infections (rhinoviruses, respiratory syncytial virus, adenovirus, etc.. High efficacy, safety and absence of adverse reactions make it possible to widely use Orvirem® in children from the first year of life, incl. with chronic diseases.  

  14. Zamyšlení nad charakterem vůdčí vrstvy městského obyvatelstva na příkladu Brna v raném novověku. Diskusní příspěvek

    Czech Academy of Sciences Publication Activity Database

    Sulitková, Ludmila

    2004-01-01

    Roč. 22, - (2004), s. 243-260, 383-384 ISSN 0231-7443. [Pražské městské elity středověku a raného novověku - jejich proměny, zázemí a kulturní profil. Praha, 01.10.2002-02.10.2002] Institutional research plan: CEZ:AV0Z8077915 Keywords : municipal elites * Early Modern Ages * Brno Subject RIV: AB - History

  15. Pre-estimation of loading on water bodies from peat production and new pollution control methods (TuVeKu); Turvetuotannon vesistoekuormituksen ennakointi ja uudet hallintamenetelmaet

    Energy Technology Data Exchange (ETDEWEB)

    Klove, B.; Saukkoriipi, J.; Tuukkanen, T.; Heiderscheidt, E.; Heikkinen, K.; Marttila, H.; Ihme, R.; Depre, L.; Karppinen, A.

    2012-10-15

    Approximately 25 million cubic metres of peat are produced in Finland each year. Furthermore 23 million cubic metres of peat is extracted for energy purposes in Finland, which is more than 50% of the world's energy peat production. Peat extraction activities such as drainage and the exposure of peat layers are known to increase the amount of water discharging from the catchment areas and to increase the loading of suspended solids and nutrients, like phosphorus and nitrogen. Hence every effort has to be made to reduce pollution from peat extraction by means of the best viable technologies that take account of the whole life-cycle impact on water bodies. Overland flow areas are considered as one of the best available technologies (BAT) for purifying run-off water. Wetlands that are constructed to already drained mires are also a common and practical method of protecting waters nowadays, as undrained areas of mires close to peat extraction areas are often lacking. Constructed wetlands however are not considered to BAT so far. The chemical purification of runoff waters is considered to one of the best available technologies. However the limiting factor for chemical treatment has often been the high costs of the method. Thus the less expensive small-scale chemical treatment has become a norm in small peat production areas with stringent purification requirements. However, there is still insufficient amount of knowledge regarding how effective drained wetlands and small-scale chemical treatment are in the purification of runoff waters. The 'Pre-estimation of loading on water bodies from peat production and new pollution control methods' project (TuVeKu) had two main objectives: (I) To assess the effect of the local and structural characteristics of the peat production areas and water treatment structures to the detected variations in the purification efficiencies. The statistical analysis is based on the gathered pollution monitoring data and gathered

  16. Türkiye’de Çalışan Y Kuşağında İş Tatmini-Motivasyon İlişkisi

    OpenAIRE

    Saracel, Nüket; Taşseven, Özlem; Kaynak, Ece

    2016-01-01

    Bilgi çağı olarak nitelenen yirmi birinci yüzyılda, bilgi ve insan organizasyonların en önemli sermayesihaline gelmiştir. Üretim kaynakları içerisinde insanın öneminin artması şirketlerin yönetiminde insangücünün motivasyonu ve iş tatminine ilişkin konuların özel önem taşıyan konular olmasını beraberindegetirmiştir. Birbirlerine yakın zamanlarda doğan insanların benzer özellikler taşıması kuşak kavramınıortaya çıkarmıştır. Her bir kuşağın farklı özelliklerinin olması, organizasyonel sistemler...

  17. Pusaudžu problemātiskas uzvedības saistības ar viņu piesaistes stilu un vecāku audzināšanas stilu ģimenē

    OpenAIRE

    Zamberga, Zane

    2006-01-01

    Maģistra darba pētījuma mērķis bija noskaidrot pusaudžu uzvedības traucējumu, piesaistes stilu un vecāku audzināšanas stilu savstarpējo saistību pusaudžu pašnovērtējumā, un, kāda ir savstarpējā ietekme (multiplās regresijas analīzes rezultātā) piesaistes stilam un vecāku audzināšanas stilam, iepretim uzvedības pašnovērtējumam. Pētījuma izlasi veido 60 pusaudži vcecumā no 14 – 16 gadiem. Tika aptaujāti Latvijas vispārizglītojošo skolu 7. un 8. klases skolēni: 30 meitenes un 30 zēni. Pētījumā...

  18. Hemşirelerin Bireysel ve Profesyonel Değerlerinde Kuşaklararası Farklılıklar / Personal and Professional Difference between the Generation of Nurses

    OpenAIRE

    IŞIK, Gülşen; EĞELİOĞLU CETİŞLİ, Nuray; TOKEM, Yasemin; YILMAZ, Dilan; İLHAN, Aylin

    2018-01-01

    Amaç: Buaraştırmanın amacı hemşirelerin bireysel ve profesyonel değerleri arasındakikuşaklararası farklılıkları belirlemektir. Gereçve Yöntem: Tanımlayıcı ve karşılaştırmalı tipteki bu çalışma, İzmir’dekibir üniversite hastanesinde çalışan, X kuşağındaki 85(doğum tarihi 1965-1979yılları arasında olanlar) ve Y kuşağındaki 79 (doğum tarihi 1980-1999 yıllarıarasında olanlar) olmak üzere toplam 164 hemşire ile yürütülmüştür. Veriler, araştırmacılar tarafından 30 dakikalık süreiçerisinde yüz yüze ...

  19. 8 – 11 gadus vecu bērnu pašcieņas saistība ar vecāku audzināšanas stilu un tehnoferenci

    OpenAIRE

    Ērmane, Linda

    2017-01-01

    Ir izvirzīts pētījuma mērķis teorētiski un praktiski izpētīt 8 – 11 gadus vecu bērnu pašcieņas saistību ar vecāku audzināšanas stilu un tehnoferenci. Pētījumā ir viena hipotēze par to, ka pastāv saistība starp vecāku audzināšanas stilu, bērnu pašcieņu un tehoferenci. Pētījuma izlasi veido 15 bērni (M = 9,6 gadi; SD = 1,12; 8 meitenes un 7 zēni) un 30 vecāki (M = 36,8 gadi; SD = 5,74; 15 vīrieši un 15 sievietes). Ir izmantoti 3 instrumenti: Audzināšanas pieeju aptauja, Tehnoloģijas ierīču ieja...

  20. DVD-filmid tõrjuvad VHSid poodidest välja / Erki Freiberg

    Index Scriptorium Estoniae

    Freiberg, Erki

    2005-01-01

    DVD- ja VHS-filmide müüjad ennustavad VHS-kassettide müügilt kadumist juba kahe aasta jooksul. Eesti ühe suurema filmide müüja AS-i V&K Holding müügijuhi Andrus Aigro sõnul suureneb DVD-de osakaal aastas ligi 30%, samal ajal kui videofilmide osakaal langeb 10%. Diagramm: DVD-filmide laenutajate arv on kasvanud üle kahe korra. Vt. samas: DVD-filmide pealetung on käimas ka Soomes

  1. E-Profiil täitis unikaalse lepingu / Erki Freiberg

    Index Scriptorium Estoniae

    Freiberg, Erki

    2005-01-01

    Maailma suurima naftapuurimisseadmete tootja National Oilwell Varco Inc naftamahutite tellimus Eesti ettevõttele E-Profiil suurendas firma käivet tunduvalt ning eelmise aasta kahjum võib pöörduda kasumiks. Diagramm: Eelmise aasta kahjum võib pöörduda kasumiks. Vt. samas: Dvigateli aktsiate müük on toonud uue salapärase omaniku; Dvigatelist on saanud valdusfirma. Diagramm: Salapärasel Dvigateli aktsiate ostjal 14,8% osalus

  2. Eesti taotleb Euroopa Liidult biodiislikütuse maksuvabastust / Erki Freiberg

    Index Scriptorium Estoniae

    Freiberg, Erki

    2005-01-01

    Rahandusministeerium taotleb Euroopa Komisjonilt Eestis müüdava autotranspordis kasutatava biokütuse vabastamist aktsiisimaksust. Lisa: Biodiislikütust tehakse taimeõlist ja alkoholist. Vt. samas: AS Biodiesel ehitab Paldiskisse tehase

  3. Y Kuşağı Turistlerin Destinasyon İmaj Algıları Üzerine Bir Araştırma A Research On Generation Y Tourists Perceptions Of Destination Image

    Directory of Open Access Journals (Sweden)

    Aslı ALBAYRAK

    2013-07-01

    Full Text Available This study has been performed on the purposed of determiningeffects of the destination image composing factors on deciding tovacation resort of Y Generation tourists who show differentcharacterists in comparison to the previous and the next generation,and making recommendations related to destination marketing for thegeneration by examining the relationship between destinationperception and structural features of Y Generation tourist.In this study, questionnaire technique which is one thequantitative research method, were used and questionnaire study weremade face to face with 384 people who were determined by quotasampling method and represent the generation in Istanbul. On analysisobtained from data were used descriptive statistics, t-test, and Anovaanalysis.According to results of research, destination image differs fromdepending on gender, level of educaiton, also income levels ofparticipants. On the other other hand, it can be said that Y Generationtourists act at the request of seeing new places, leisure, andentertainment and are the individuals who look for quality and luxuryholiday with affordable price.Touristic purchase process is shaped by many factors. One of thefactors affecting this process is image of destination. The mostgenerational definition about destination image is as an individual’soverall perception and these perceptions ınfluenced by many factorssuch as age, education, income and culture. There are several studieshave been conducted about tourists’ perceptions of destination image inpast and generally these studies about effects of tourists’ characteristicssuch as age, education, culture income to perception of destinationimage but there are no studies about different generations’ destinationimage perceptions. Therefore ıt’s thought that the results obtained fromthis study could contribute to the tourism marketers. Bu çalışma, kendinden önceki ve sonraki kuşaklardan farklı özellikler gösteren Y ku

  4. Beretning for undersøgelse af bopladsområde med værkstedsaktivitet fra yngre jernalder/vikingetid, neolitiske anlæg fortrinsvis fra MN A III og en grav fra MN B II. Kalmergården (KU) 2000

    DEFF Research Database (Denmark)

    Bican, Josefine Franck

    2001-01-01

    anlæggelse er omtalt nedenfor i en separat beretning ved Lone Gebauer Thomsen (se bilag 2). Yngre jernalder/vikingetid er den periode, der var bedst repræsenteret på pladsen. Her var spor efter en markeds-/produktionsplads, der er registreret vha. 3735 detektorfund, hvor især sølvskatten (KU 2337) skal...

  5. X ve Y Kuşağı: Hemşirelerin Meslek Dayanışması İle İş Doyumu Arasındaki İlişki

    OpenAIRE

    KARASU, Fatma; AYLAZ, Rukuye

    2017-01-01

    Amaç:Bu araştırma, X ve Y kuşağındaki hemşirelerin meslek dayanışması ile iş doyumuarasındaki ilişkisini belirlemek amacıyla yapılmıştır. Gereç ve Yöntem: Kesitsel nitelikteki araştırmanın evrenini devlethastanesinde çalışan hemşireler oluşturmuş, örneklem seçimine gidilmeyerekevrenin tamamı örnekleme dahil edilmiş ve 01.02.2017-01.03.2017 tarihleriarasında çalışmayı kabul eden toplamda 145 hemşireye ulaşılmıştır. Veri toplamaformunda, hemşirelerin sosyo-demografik özellikleri, Hemşirelerde M...

  6. Ocena poziomu lęku i depresji u rodziców dzieci z zespołem nerczycowym – sposoby radzenia sobie z nimi i metody wsparcia

    Directory of Open Access Journals (Sweden)

    Monika Pawlak-Bratkowska

    2013-06-01

    Full Text Available Wstęp i cele pracy: Idiopatyczny zespół nerczycowy w wieku rozwojowym przebiega nawrotowo i trwale zmie‑ nia życie dzieci oraz ich rodziców. Celem badania była ocena poziomu lęku i depresji u rodziców dzieci z zespo‑ łem nerczycowym. Materiał i metodyka: Badanie zaplanowano jako przekrojową próbę kliniczną wśród rodzi‑ ców dzieci chorujących na zespół nerczycowy w odniesieniu do rodziców dzieci zdrowych. Wszyscy badani (46 rodziców wypełniali: ankietę dotyczącą przebiegu choroby u dziecka, kwestionariusz STAI (Inwentarz stanu i cechy lęku, kwestionariusz Skali depresji Becka, kwestionariusz Skali kontroli emocji (CECS. Grupę kontrolną stanowiło 20 rodziców dzieci zdrowych. Wyniki: Rodzice dzieci z zespołem nerczycowym charakteryzowali się istotnie wyższym poziomem depresji (Skala depresji Becka 8,7 vs 4,9, t = 2,18, p < 0,05. U ojców zaobserwo‑ wano wyższe subiektywne uczucie kontrolowania własnych reakcji w porównaniu z matkami – wyższy wynik CECS, suma u ojców (55,1 vs 47,2, t = 2,53, p < 0,05. U matek odnotowano wyższe wskaźniki zarówno w ska‑ lach mierzących poziom lęku jako cechy (STAI – cecha 45,7 vs 36,1, t = 3,19, p < 0,05 i stanu (STAI – stan 42,8 vs 33,4, t = 2,8, p < 0,05, jak i w kwestionariuszu badającym poziom depresji (10,62 vs 4,86, t = 2,66, p < 0,05. Rodzice, którzy wykazywali tendencję do obwiniania się o chorobę dziecka, podczas jej pierwszego epizodu uzyskali statystycznie istotny wyższy wynik w testach badających poziom depresji. Wnioski: Rodzice dzieci cierpiących na zespół nerczycowy charakteryzowali się istotnie wyższym poziomem depresji niż rodzice dzieci zdrowych. Ważne wydaje się objęcie szczególną opieką matek, mającą na celu obniżenie poziomu lęku i objawów depresji, oraz ojców skłonnych do tłumienia przeżywanych emocji.

  7. Uticaj povećanja dometa na dinamičku stabilnost artiljerijskih raketa sa olučastim krilima / Influence of range extension on dynamic stability for artillery rockets with wrap around fins

    Directory of Open Access Journals (Sweden)

    Danilo Ćuk

    2007-07-01

    Full Text Available U radu su prikazani efekti povećanja dometa artiljerijske rakete sa olučastim krilima na njenu dinamičku stabilnost. Totalni impuls raketnog motora, uvećan za 50% i let rakete kroz slojeve atmosfere sa malom gustinom vazduha povećavaju domet rakete za više od 75% od nominalnog dometa. Međutim, let rakete kroz razređeni vazduh proizvodi teškoće koje se odnose na dinamičku stabilnost. Male promene bočnog momenta indukovanog napadnim uglom i Magnusovog momenta mogu proizvesti nestabilnost kretanja i nedozvoljeni rast napadnog ugla. Određene su tolerancije bočnog momenta za osnovnu i poboljšanu varijantu rakete radi sprečavanja nestabilnog leta. Analiziran je, takođe uticaj povećanja dometa na verovatna odstupanja rakete po dometu i pravcu. / This paper presents the effects of the range extension of an artillery rocket with wrap around fins on its dynamic stability. The increased total impulse of the rocket engine for 50% and flight through the atmosphere layers with low air density extend the range for more than 75% of the nominal range. However, the flight of the unguided rocket through the rarefied air produces difficulties related to the dynamic stability. The small changes in the side moment which is induced by the angle of attack and Magnus moment of the improved rocket can produce instabilities in flight and increasement the angle of attack. The tolerances of the side moment were determined for both basic and improved type of the rocket in order to prevent instable flight. The influence of the range extension on the probable errors in range and cross-range was analyzed as well.

  8. Kuş Gölü (Bandırma Makrobentik Omurgasız Faunası Hakkında Bir Ön Araştırma.

    Directory of Open Access Journals (Sweden)

    Süleyman Balık

    2015-12-01

    Full Text Available Kuş Gölü’nün makrobentik omurgasız faunasını belirlemek amacıyla 1987 ve 1988 yılları arasında aylık periyotlar halinde, bir yıl süre ile 5 istasyonda arazi çalışması yapılmıştır. Ekman grab ile alınan çamur örnekleri 500 μm göz açıklığındaki elekten geçirilmiş ve örnekler %4’lük formaldehit solüsyonunda tespit edilmiştir. Araştırma sonucunda, Oligochaeta sınıfından 10, Chironomidae familyasından 5 ve Ceratopogonidae familyasından 1 olmak üzere toplam 16 takson tespit edilmiştir. Kuş gölü’nde metrekarede ortalama 6759 birey tespit edilmiş, grupların oransal dağılımında %81,94 ile Oligochaeta bireylerinin en baskın grubu oluşturduğu, bu grubu Chironomidae (%17,90 ve Ceratopogonidae (%0,16 larvalarının takip ettiği saptanmıştır. Tespit edilen grupların istasyonlara göre oransal dağılımlarında ise, 1. istasyonun en zengin (%28,71, 4. istasyonun en fakir (%12,77 istasyon olduğu gözlenmiştir

  9. Pusaudžu - hokeja spēlētāju sasniegumu stratēģijas un apmierinātības izjūta, spēlējot hokeju, saistībā ar vecāku audzināšanas stiliem.

    OpenAIRE

    Stālmane, Liene

    2014-01-01

    Maģistra darba mērķis bija izpētīt saistības starp pusaudžu, kuri trenējas hokejā jau no agrīna vecuma, sasniegumu stratēģijām, apmierinātības izjūtu, spēlējot hokeju, un viņu vecāku audzināšanas stilus. Pētījumā tika iekļauti 53 respondenti latviešu tautības zēni, vecumā no 9 – 14 gadiem, kuri trenējas hokejā. Par pētījuma instrumentāriju izmantotas: 1)Vecāku audzināšanas stila aptauja. (Parental Authority Questionnaire (PAQ), Buri, 1991); 2) Sasniegumu stratēģiju aptauja....

  10. Styl radzenia sobie ze stresem jako moderator związku lęku z neurotyzmem u osób z reumatoidalnym zapaleniem stawów

    Directory of Open Access Journals (Sweden)

    Michał Ziarko

    2011-06-01

    Full Text Available Lęk stanowi jedną z konsekwencji chorób przewlekłych, w tymreumatoidalnego zapalenia stawów (RZS. Wysoki poziom lękuobniża jakość życia pacjentów, prowadzi do zachowań antyzdrowotnychoraz może wpływać na gorszy przebieg choroby. Związekneurotyzmu z lękiem został dotąd dobrze udokumentowany. Neurotyzmstanowi cechę temperamentu, a więc w niewielkim stopniumożna ją modyfikować. Redukcja kosztów psychicznych ponoszonychprzez osoby o wysokim poziomie neurotyzmu wymagapoznania czynników, które mogłyby ograniczać wpływ neurotyzmuna poziom lęku (czynniki moderujące relację neurotyzm–lęk.Celem badania było określenie zmiennych moderujących relacjępomiędzy neurotyzmem a lękiem.W badaniach wzięło udział 100 osób chorujących na RZS (78 ko -biet i 22 mężczyzn. Zostali oni przebadani za pomocą kwestionariuszymierzących: poziom lęku, style radzenia sobie ze stresemoraz wymiary osobowości. Obliczono współczynniki korelacjir Pearsona pomiędzy mierzonymi zmiennymi oraz wykonano analizęmoderacji związku pomiędzy neurotyzmem a lękiem jakostanem za pośrednictwem stylów radzenia sobie ze stresem.Testowanie interakcji przeprowadzono metodą najmniejszych kwadratówi regresji logistycznej.Ustalono, że istnieje wprost proporcjonalny związek pomiędzyneurotyzmem a lękiem rozumianym jako stan (r = 0,63; p < 0,01(tab. I. Zaobserwowano, że związek ten nie zachodzi w przypadkuosób o wysokim neurotyzmie posługujących się unikowym stylem radzenia sobie ze stresem (R2 = 0,19; F = 7,00; p < 0,001 (ryc. 1oraz u osób poszukujących kontaktów towarzyskich (R2 = 0,22;F = 8,70; p < 0,001 (ryc. 2, tab. II.Wyniki wskazują, że silny neurotyzm zwiększa prawdopodobieństworeagowania podwyższonym poziomem lęku w obliczu pojawiającychsię objawów oraz zagrożeń będących konsekwencjąchoroby. Zaobserwowane zależności potwierdzają hipotezę, żetemperament jest czynnikiem ryzyka w rozwoju zaburze

  11. Akadēmiskās pašregulācijas saistība ar pusaudžu personības iezīmēm un vecāku audzināšanas stiliem

    OpenAIRE

    Iliško, Judīte

    2016-01-01

    Maģistra darba pētījuma mērķis bija noskaidrot, kāda saistība pastāv starp pusaudžu pašnovērtēto akadēmisko pašregulāciju, vecāku audzināšanas stiliem un pusaudžu personības iezīmēm, kā arī, vai pastāv dzimuma atšķirības starp pusaudžu pašnovērtēto akadēmisko pašregulāciju, vecāku audzināšanas stiliem un personības iezīmēm, un, cik lielā mērā pusaudžu personības iezīmes un vecāku audzināšanas stili prognozē pusaudžu akadēmisko pašregulāciju. Pētījumā piedalījās 225 7.-8.klašu skolēni no vien...

  12. Mechanický návrh průběžného zásobníku příze a jeho realizace

    OpenAIRE

    Klusoň, Vladimír

    2014-01-01

    Práce se zabývá vývojem zařízení Průběžného zásobníku příze pro textilní stroj. Průběžný zásobník přízeobsahuje poháněný navíjecí válec s rotačním kompenzátorem napětí příze, flyerem. Poháněný otočný zásobník je spřažen s prvním pohonem tvořeným elektrickým motorem a rotační kompenzátor je spřažen s druhým pohonem tvořeným elektrickým motorem, přičemž oba motory jsou napojeny na řídicí systém. Zařízení Průběžný zásobník příze efektivně zvyšuje stupeň automatizace textilního stroje. This th...

  13. Gaistošo organisko savienojumu emisijas no kuņģa vēža audiem un to potenciālā bioloģiskā saistība

    OpenAIRE

    Aronsson, Dan Erik

    2018-01-01

    Gaistošā organiskā savienojuma (VOC) emisija, ko var novērot izelpā, ir strauji augoša diagnostikas metode audzēju izmeklēšanā. VOC ir savienojums, kam istabas temperatūrā ir augsts tvaika spiediens, kas veicina tā iztvaikošanu gāzes formā. Šo gāzi var noteikt cilvēka audos un šķidrumos.( Haick et al 2014) Galvenokārt ir pētīta VOC saistība ar plaušu vēzi. Taču aizvien vairāk tiek veikti pētījumi, lai noteiktu, kādas ir iespējas VOC pielietot arī kuņģa audzēja gadījumā. Tā kā VOC molekula sp...

  14. Pilot testing of the Czech versions of the Coaching Behavior Assessment Questionnaire structure [Pilotní testování struktury české verze dotazníku Coaching Behavior Assessment Questionnaire

    Directory of Open Access Journals (Sweden)

    Martin Musálek

    2012-03-01

    Martin a Kelly Barnes vytvořili v roce 1999 dotazník Coaching Behavior Assessment Questionnaire, který vychází z CBAS (Smith a kol., 1977 a LSS (Chelladurai & Saleh, 1978, 1980. V současné době není v České republice podobný diagnostický nástroj pro hodnocení chování trenéra. CÍLE: Cílem této pilotní studie bylo přeložit a ohodnotit strukturu dotazníku CBAQ metodou strukturálního modelování pro populaci dětí ve věku 10 – 16 let. METODIKA: Pro účel překladu dotazníku byla použita modifikovaná metoda přímého překladu (Behling & Law, 2000. Dotazník vyplnilo 100 účastníků ve věku 10 – 16 let, 63 děvčat (průměrný věk 13,02; SD = 2,10, 37 chlapců (průměrný věk 13,27; SD = 1,37. Pro analýzu dat byla použita exploratorní a konfirmační faktorová analýza. VÝSLEDKY: Původní model byl testován za účelem ověření struktury a diagnostické kvality tohoto nástroje. Výsledky původního 12-faktorového modelu CBAQ ukázaly slabý fit modelu s podprůměrnými hodnotami indexů fitu RMSEA = 0,082, CFI = 0,600 a také nízké koeficienty generické reliability. Z tohoto důvodu jsme se rozhodli pro re-analýzu dat, ze které byla vytvořena modifikovaná 5-faktorová struktura CBAQ. Tento 5-faktorový model s omezeným počtem položek ukázal nejlepší hodnoty indexů fitu RMSEA = 0,056; CFI = 0.964 a také akceptovatelné hodnoty generické reliability. ZÁVĚRY: Tato studie měla pilotní charakter, uvědomujeme si proto, že snížení velkého počtu položek u této modifikované verze vedlo ke ztrátě informace. Přesto se domníváme, že by tato finální 5-faktorová verze s 15 položkami mohla tvořit základ pro budoucí připravovanou plně standardizovanou českou verzi CBAQ.

  15. Izbor faktora rotacije vektora potiska za balističku raketu sa Lambertovim vođenjem / Choice of the rotational factor of the thrust vector for the ballistic missile with Lambert guidance

    Directory of Open Access Journals (Sweden)

    Danilo V. Ćuk

    2008-04-01

    Full Text Available Predmet rada jeste primena Lambertovog vođenja na balističku raketu. Koristeći fundamentalnu jednačinu za upravljački vektor brzine razvijena je formula za određivanje ugla orijentacije vektora potiska u zavisnosti od faktora rotacije njegovog pravca. Izvedena formula zahteva Q-matricu koja povezuje diferencijalnu promenu vektora položaja rakete sa odgovarajućom diferencijalnom promenom korelisane brzine za fiksnu poziciju cilja i konstantno vreme slobodnog leta rakete. Izborom parametra rotacije vektora potiska dobijaju se različiti profili ugaonog položaja rakete i ugla njene brzine u zavisnosti od vremena. Podešavanjem parametra rotacije vektora potiska moguće je ostvariti prekid rada raketnog motora pri nultom napadnom uglu i, na taj način, smanjiti početne poremećaje slobodnog leta rakete. / This paper deals with the application of the Lambert guidance to the ballistic missile. By using the fundamental equation for the velocity-to-be-gained, the demanded command for the thrust angle is developed in terms of the rotational factor of its direction. The developed formula requires the Q-matrix which links a differential change in the missile position vector to the corresponding differential change in the correlated velocity for the fixed target position and the constant time of free flight. The choice of the rotational parameter provides different profiles of the missile attitude and flight path angle with time. By adjusting the rotational parameter for the thrust vector, the cut-off of the rocket engine can occur at zero angle of attack and the initial perturbations during free flight may be thus reduced.

  16. Rozbor morfologie nohy u chlapců a dívek ve věku Infans 2 a Juvenis Analysis of morphology of foot in Moravian male and female students in the age Infans 2 and Juvenis

    Directory of Open Access Journals (Sweden)

    Michaela Peštuková

    2005-02-01

    Full Text Available U 106 studentů a 162 studentek z Gymnázia ve Šternberku a Střední integrované školy v Ostravě ve věku 12–18 let byl sledován morfologický typ nohy, index nohy pro hodnocení podélné klenby nožní, vyosení palce a malíku, úhel paty a stav svalstva dolních končetin. U chlapců i dívek byla nalezena výrazně vyšší frekvence výskytu nohy egyptské (71,69 % a 70,99 %. Noha kvadratická se vyskytovala u chlapců ve velmi nízkém procentu (2,83 % s určitou individuální asymetrií, u dívek nalezena nebyla. Diagnostika plochonoží metodou Chippauxe–Šmiřáka poskytla velmi příznivé výsledky (4,94–10,38 % výskytu ploché nohy, metoda podle Szritera–Godunova naopak nález podstatně horší (38,2–43,21 % výskytu ploché nohy. S nulovým stavem vyosení palce jsme se setkali u necelé čtvrtiny souborů. U souboru chlapců byla četnost projevu valgozity a varozity palce téměř vyrovnána, věcně převažovalo varózní postavení palce vpravo. U souboru dívek dominovalo signifikantně valgózní postavení. Průměrné hodnoty se pohybovaly v rozmezí 4 až 7 stupňů. Průměrná hodnota úhlu malíku, charakterizující vbočený malík, byla vysoká (17,73 až 21,90 stupně. Průměrný úhel paty byl diagnostikován v rozmezí 15 až 18 stupňů. Při hodnocení vztahů mezi zkrácením svalů dolní končetiny a poruchami funkčního stavu klenby nožní (pouze u mužů jsme nalezli potvrzení statistické významnosti závislosti u vyosení paty a zkrácení m. triceps surae sin. a signifikantní závislost mezi úhlem paty a zkrácením flexorů kolen sin. Morphological foot type, foot index for longitudinal foot vault, misalignment of the big and little toes, heel angle and lower limb muscles condition were monitored in 106 male students and 162 female students from the Gymnasium school in Šternberk and the Integrated secondary school in Ostrava ranging in age from 12 to 18 years. A considerably

  17. Development of active barriers for removing heavy metals from mine water: Freiberg colliery, Sachsen; Entwicklung aktiver Barrieren fuer die Entfernung von Schwermetallen aus Grubenwaessern am Beispiel der Freiberger Grube, Sachsen

    Energy Technology Data Exchange (ETDEWEB)

    Zoumis, T.

    2003-07-01

    Mine water treatment is costly, difficult, and requires extensive surface installations. The author explains the development of geochemical ('active') barriers of low-cost materials. The materials investigated were industrial residues (red sludge, fly ash, tinder residues, porous concrete residues), natural materials (bark, zeolite, bentonite, hydroxyl apatite), and commercial products (GEH, Ratio Pur MF-S). Investigations focused on density, specific surface, grain size, and acid neutralization capacity. In the final stage, experiments were made on heavy metal removal from a model water. [German] Einen grossen Anteil an der Schwermetallbelastung in Fluessen haben toxische Abwaesser aus Bergbaugebieten (Grubenwaesser). Die Moeglichkeit der Behandlung sind sehr aufwendig, kostenintensiv und nur 'ueber Tage' durchfuehrbar. Die vorliegende Arbeit erlaeutert die Behandlung von Grubenwaessern mit geochemischen ('aktiven') Barrieren. Es werden aktive Barrieren entwickelt, die in einen Schacht eingebracht werden koennen, um eine Schwermetallausbreitung zu unterbinden. In diesem Zusammenhang werden kostenguenstige Materialien untersucht, die Schadstoffe durch chemische und/oder physikalische Mechanismen aus Wasser entfernen koennen. Untersucht wurden industrielle Reststoffe (Rotschlamm, Flugasche, Zunderrueckstaende, Porenbetonabfall), natuerliche Materialien (Baumrinde, Zeolith, Bentonit, Hydroxylapatit) und kommerzielle Produkte (GEH, Ratio Pur MF-S). Die Materialien werden hinsichtlich der Dichte, der spezifischen Oberflaeche, der Korngroesse und der Saeureneutralisationskapazitaet charakterisiert. Anschliessend wurden Versuche zur Schwermetallentfernung aus einem Modellwasser durchgefuehrt. (orig.)

  18. Questionnaire regarding the international Freiberg conference on IGCC and XtL technologies. Analysis of 75 questionnaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The Puertollano IGCC Plant, owned by ELCOGAS, uses a mixture (50/50% weight) of local coal with high content of ash (approximately 45%) and pet-coke to be fed into its pressurised entrained flow gasifier. Ash is removed from the bottom of the gasifier as vitrified slag although a fraction is converted into fly ash (2.5-3 t/h) and entrained by the syngas. In order to remove this fly ash, it is filtered in two candle filter vessels with more than 1,000 candles each, using nitrogen for on-line cleaning. The filtering system suffers some malfunctions resulting in blinding of the internal candle surface and increasing of the candle DP. The model of candle filter was changed and modifications were performed without the desired results. Therefore, the identification of suitable hot gas filtration technologies capable of overcoming current and future severe operational constraints experienced is of the utmost importance for IGCC units. In this sense, a pilot plant which allows the performance of alternative filtering elements tests, pulse cleaning strategies, on-line particulate monitoring and off-cleaning procedures has come into operation at the ESI-University of Seville facilities. The design has been conceived as a versatile pilot unit, in order to hold both bags and ceramic candles which are to be tested in a wide range of operating conditions. The pilot is processing air laden with real fly ash provided by ELCOGAS, and high pressure nitrogen for the cleaning operation. This paper describes the design and operation of the pilot as well as the testing plan currently being carried out. (orig.)

  19. Wybrane zagadnienia dotyczące wpływu wysiłku fizycznego na organizm człowieka=Selected issues concerning the impact of physical exercise on the human organism

    Directory of Open Access Journals (Sweden)

    Wojciech Wojtasik

    2015-10-01

    3      Instytut Kultury Fizycznej, Uniwersytet Kazimierza Wielkiego w Bydgoszczy   Słowa kluczowe: aktywność fizyczna, wysiłek fizyczny, geny i aktywności fizyczna Keywords: physical activity, physical effort, genes and physical activity   Cel i zakres pracy Ludzie, już w starożytnej Grecji, przywiązywali dużą wagę do zdrowego trybu życia, którego wyznacznikami są m. in.: siła mięśniowa, koordynacja nerwowo-mięśniowa, wydolność krążeniowo-oddechowa. Wysiłek fizyczny oddziałuje na poszczególne układy organizmu człowieka, w tym szczególnie na układ ruchu, krwionośny i oddechowy, neuro-hormonalny, a przez to na funkcjonowanie wielu narządów wewnętrznych. Od wieków prowadzone są liczne badania mające na celu poznanie zmian zachodzących w organizmie na skutek aktywności fizycznej. Zmiany w funkcjonowaniu organizmu poddanemu określonemu wysiłkowi fizycznemu (zarówno statycznemu jak i dynamicznemu określane są poprzez zastosowanie diagnostyki medycznej, praw fizycznych oraz diagnostyki sportowej. W pracy opisano zmiany, jakie zachodzą w organizmie człowieka w czasie wysiłku fizycznego, w takich układach jak: kostno-stawowy, mięśniowy, krwionośny, czy też oddechowy. Opisano także procesy przystosowawcze organizmu i wykazano korzystne oraz niekorzystne działanie (fizyczne, psychiczne i społeczne aktywności fizycznej na organizm człowieka. Sklasyfikowano również wysiłek fizyczny w zależności od przyjętych obecnie kryteriów. Artykuł stanowi częściowe podsumowanie zainteresowań naukowych autorów w latach 2014-2015.

  20. 10- 12 gadus vecu bērnu ar atkārtotu nesekmību iemācītās bezpalīdzības saistība ar vecāku iemācīto bezpalīdzību

    OpenAIRE

    Lamstere, Jolanta

    2006-01-01

    Darbā tika pētīta iemācītās bezpalīdzības saistība bērniem ar vecāku iemācīto bezpalīdzību. Pētījuma gaitā tika izvirzīti pētījuma jautājumi: vai pastāv statistiski nozīmīgas sakarības starp iemācītās bezpalīdzības rādītājiem 10- 12 gadus veciem bērniem ar atkārtotu nesekmību un viņu vecāku iemācītās bezpalīdzības rādītājiem; vai pastāv statistiski nozīmīgas atšķirības starp iemācītās bezpalīdzības rādītājiem bērniem ar atkārtotu nesekmību un sekmīgiem bērniem; vai pastāv statistiski nozīmīga...

  1. Pašvērtējuma, apmierinātības ar dzīvi un agresijas atšķirības pieaugušajiem ar un bez bērnībā pieredzētas vecāku šķiršanās

    OpenAIRE

    Ekarte, Marika

    2013-01-01

    Pētījuma mērķis ir noskaidrot vai pastāv atšķirības starp uzrādītajiem pašvērtējuma, apmierinātības ar dzīvi un agresijas rādītājiem respondentiem ar bērnībā pieredzētu vecāku šķiršanos un respondentiem bez vecāku šķiršanās pieredzes, kontrolējot dzimumu. Pētījuma mērķa noskaidrošanā pielietota pašvērtējuma aptauja (Rosenberg Self-Esteem Scale, RSE, Rosenberg, 1965), apmierinātības ar dzīvi aptauja (Satisfaction with life scales. Diener, 1985), agresijas līmeņa noteikšanai - agre...

  2. Ultra-compact Ku band rectenna

    OpenAIRE

    Takacs , Alexandru; Aubert , Hervé; Charlot , Samuel

    2015-01-01

    International audience; This paper addresses an innovative and ultra-compact rectenna designed for energy harvesting or wireless power transfer applications. The presented rectenna uses a printed cross dipoles antenna array and a rectifier implemented with only one silicon Schottky diode. Experimental results show that 1.15 mW of DC power can be obtained for an optimal load impedance of 500 Ω using a compact rectenna (2.5 cm 2 or 0.6 square wavelength) illuminated by an electric field of 60 V...

  3. Gözeli yöresindeki (Elazığ meşe (Quercus sp . ormanlarına asılan yapay yuvalardaki böcekçil kuşların kuluçka faaliyetleri

    Directory of Open Access Journals (Sweden)

    Özden YALÇIN

    2015-12-01

    Full Text Available Elazığ Orman Bölge Müdürlüğü sınırları içerisinde yer alan Elazığ ili Sivrice ilçesi Gözeli mevkiinde bulunan meşe ormanlarında, 2009-2013 yılları arasında gerçekleştirilen bu çalışma ile farklı bakılara asılan farklı renkteki küçük ve büyük yuva sandıklarında yuva yapan kuş türleri ve bu türlerin kuluçka faaliyetlerinin saptanması amaçlanmıştır. Kuluçkalarını başarı ile tamamlayan kuş türlerinin Otus scops haricindeki türlerin hepsi, hem küçük hem de büyük yuvaları kullanmıştır. Öncelikli yuva tercihleri şu şekilde olmuştur: Parus major küçük yuvaların %66,4’ünde, Cyanistes caeruleus büyük yuvaların %16,3’ünde, Sitta europaea büyük yuvaların %23,2’sinde, Petronia petronia küçük yuvaların %15,2’sinde, Passer domesticus büyük yuvaların %27,9’unda, Otus scops ise sadece büyük yuvaların %7’sinde yuvalanmıştır. Asılan yuvalarda başarılı kuluçka durumunun farklı kuş türlerine göre bakı tercihleri arasında farklılıklar bulunmaktadır. Büyük yuvalarda güney (%39,5, doğu (%34,9, kuzey (%16,3 ve batı (%9,3’dır. Küçük yuvalarda ise güney (%33,2, doğu (%27,2, batı (%20,8 ve kuzey (%18,8’dir.Farklı renklerde asılan kuş yuvalarında başarılı kuluçka yapan kuş türlerinin renk tercihleri değişmektedir. Büyük yuvalarda, Parus major yeşil yuvaları, Cyanistes caeruleus sarı yuvaları, Sitta europaea turuncu yuvaları, Petronia petronia sarı ve mavi yuvaları, Passer domesticus sarı, mavi ve boyanmamış yuvaları daha fazla tercih etmişlerdir. Kuşların yuva tercihinde yuva boyutu, renk ve bakının türler arası farklılık gösterdiği ortaya çıkmıştır. Bir türün daha yoğun bulunduğu alanda, o türe uygun yuva tercihinin gerçekleştirilerek asılması biyolojik mücadele kapsamında daha verimli sonuçlar elde edilmesini sağlayacaktır.

  4. Faktorová analýza antropometrických charakteristik u mladých plavců ve věku 11 a 12 let Factor analysis of anthropometric characteristics in young swimmers aged 11 and 12

    Directory of Open Access Journals (Sweden)

    Zofia Ignasiak

    2006-02-01

    Full Text Available Cílem této práce bylo popsat vybrané somatické charakteristiky typické pro mladé plavce. Faktorová analýza umožnila úměrné snížení somatických ukazatelů a umožnila vypočítat hlavní strukturální faktory typické pro mladé plavce. Do výzkumného souboru bylo zařazeno 80 žáků (11 a 12letých přijatých ke studiu na základní sportovní škole ve Wroclawi. Sledovaní probandi trénovali po dobu 2–3 let a jejich průměrný tréninkový čas byl 12 až 18 hodin týdně. Byly měřeny následující parametry: tělesná výška a hmotnost, délka horních a dolních končetin, obvod stehen, lýtka, paží, předloktí, hrudníku v klidu, hrudníku po nádechu a po výdechu, obvod pasu a boků, šířka ramen, šířka boků, šířka hrudníku, hloubka hrudníku a Rohrerův index. K dosažení cíle této studie byla použita metoda faktorové analýzy. Analýza výsledků ukázala, že pouze některé zvláštnosti mezi sledovanými parametry jsou pro mladé plavce charakteristické. Jsou spojeny do 2 trsů somatických charakteristik: kubický obsah (zahrnuje tělesnou hmotnost, svalstvo, trup a obvod horních a dolních končetin a vertikální rozměr (zahrnuje tělesnou výšku a délku horních a dolních končetin. Tyto parametry signalizují formování postavy typické pro plavce, charakteristické specifickými proporcemi tělesné hmotnosti a výšky, hrudníku a boků a obvykle delšími končetinami. Výsledky naznačují, že antropometrické charakteristiky lze použít pro optimalizaci tréninkového procesu mladých plavců. The aim of this study was to describe the set of somatic characteristics, which significantly discriminate young swimmers. The factor analysis let us reduce the number of somatic traits mostly correlated and to calculate the main structural factors typical for young swimmers. There were 80 pupils (11 and 12 years old from the primary sport school in Wroclaw recruited for the study

  5. Kunstnike Liidu volikogu koosolek toimus 20. X Ku-Ku klubis

    Index Scriptorium Estoniae

    2003-01-01

    Kinnitati EKLi 2004. a. eelarve, selle toetustest. Harry Liivrand tutvustas Kunstihoone ja selle galerii, Reet Varblane Linnagalerii, Elin Kard Hobusepea ja Draakoni galerii 2004. a. näituseplaane. Ateljee Vabaduse väljak 6-35 otsustati anda rendile Ülle Marksile, ateljee Ristiku 27 müüa Rafael Arutjunjanile. EKLi uued liikmed: Andrus Joonas, Alice Kask, Hermes Sarapuu, Epp Viires, Kristel Sibul

  6. The Effect of the Unique Features of Y Generation on Organizational Commitment / Y Kuşağının Belirleyici Özelliklerinin Örgütsel Bağlılık Üzerindeki Etkisi

    Directory of Open Access Journals (Sweden)

    Mustafa Emre Civelek

    2017-12-01

    Full Text Available ABSTRACT In this research, the determinants of the generations and unique characteristics of Generation Y are examined and the effect of this unique characteristics on organizational commitment is investigated. In the introduction part of the research, different features separating the generations from each other were mentioned and the studies done in this subject were examined and the studies and findings of different researchers were evaluated. In the final part of the survey, there is the analysis result of the survey collected from overall Turkey from 8 corporations. Sample size of this research is 267.  In order to measure organizational commitment, the scale developed by Allen and Meyer was used (Allen & Meyer, 1993. In order to measure team working, the scale developed by Levi and Slem was used (Levi & Slem, 1995. In order to measure playful spirit at work, the scale developed by Berg was used (Berg, 2011. According to the test results, there is a positive and significant relationship between Workplace fun and Team Working and between Team Working and Organizational Commitment. Contrary to expectation, there is not directly relation between organizational commitment and workplace fun. But work place fun positively effects organizational commitment through team working indirectly. The results of this research are to confirm that employees will be more likely to work in teams if organization environments are established to make them happy and entertained, thereby increasing their organizational commitment. ÖZ Bu araştırmada Kuşakların belirleyici özellikleri incelenerek Y kuşağını diğer kuşaklardan ayıran özelliklerin neler olduğu ve bu özelliklerin örgütsel bağlılık üzerinde ne gibi bir etkisi olduğu araştırılmaktadır. Araştırmanın giriş kısmında kuşakları birbirinden ayrıştıran farklı özelliklere değinilmiş ve bu konuda yapılan çalışmalar incelenerek farklı araştırmacıların

  7. ВПЛИВ ПОРОГОВИХ УМОВ ITU НА ЕФЕКТИВНІСТЬ ВИКОРИСТАННЯ ГЕОСТАЦІОНАРНОЇ ОРБІТИ В Ku ДІАПАЗОНІ

    OpenAIRE

    Kolomytsev, M. A.; Lipatov, A.; Synepolski, Y.

    2014-01-01

    The article is devoted to the estimation of threshold values, regulated by ITU, which determine the necessity of satellite networks coordination in the Ku band. Maximum capacity of geostationary orbit (GEO) for different diameters ofearth station antennas, operating in standard DVB-S2 accounting the limitations caused by the parameters of existing satellite networks equipment, is determined. Optimal values of satellites’ orbital separation, relative increase in allowablenoise / and the signal...

  8. Vecāku prombūtnes un klātesošā vecāka audzināšanas pieejas saistība ar pusaudžu depresijas pazīmēm

    OpenAIRE

    Ločmele, Renāte

    2014-01-01

    Pētījuma mērķis bija noskaidrot, kādas ir saistības starp vecāku prombūtni, klātesošā vecāka audzināšanas pieeju un pusaudžu depresijas pazīmēm. Pētījumā piedalījās 62 respondenti – 37 meitenes un 25 zēni vecumā no 11 līdz 16 gadiem. Respondentu vidējais vecums bija 14 gadi. Tie tika sadalīti divās grupās: vienā grupā bija pusaudži, kuriem viens no vecākiem atrodas prombūtnē (n=31), otrā grupā bija pusaudži, kas dzīvo kopā ar abiem vecākiem ( n=31). Datu ievākšanai tika izmantotas sekojoš...

  9. Agresijas un vecāku audzināšanas stila saistība jauniešiem no profesionālās vidējās izglītības iestādēm

    OpenAIRE

    Stikāne, Austra

    2012-01-01

    Pētījuma jautājumi ir vai pastāv saistība starp agresijas rādītājiem un vecāku audzināšanas stilu profesionālās vidējās izglītības iestāžu audzēkņiem, kuri ikdienā dzīvo ar vecākiem un audzēkņiem, kuri ikdienā nedzīvo ģimenē, kā arī vai pastāv atšķirības agresijas skalās starp jauniešiem, kuri dzīvo ar vecākiem ikdienā un jauniešiem, kuri ikdienā nedzīvo ar vecākiem. Pētījumā piedalījās 95 respondenti (55 studenti, kuri ikdienā dzīvo ar vecākiem, 40 studenti, kuri ikdienā nedzīvo ģimenē)...

  10. Archaeological investigations at the late iron age settlement site of Huntaugu and at the castle of teutonic order in Viljandi / Arvi Haak

    Index Scriptorium Estoniae

    Haak, Arvi

    2005-01-01

    Huntaugu mäel paiknenud lühiajalistest väikestest asustusüksustest. Viljandi ordulinnuse eeslinnuse hoovialal 14. saj. keskel toimunud muudatustest, kaevamistest esimese eeslinnuse alal, varisenud konvendihoone müüridest, leiumaterjali kirjeldus

  11. Archaeological investigations at the town wall of Viljandi and the construction site Tartu street 8A / Arvi Haak, Priit Lätti

    Index Scriptorium Estoniae

    Haak, Arvi, 1978-

    2006-01-01

    Linnamüüri väljapuhastamisest Viljandi raekoja taga. Järelvalvetöödega Tartu tänaval selgus, et keskaegne kiht uuritaval alal puudus (või polnud tekkinud), kultuurkiht sisaldas 18. ja 19. saj. leide

  12. Värtnakeder, talisman või nõiaese - märkidega kiviketas Viljandimaalt Rattama talust / Tõnno Jonuks, Meelis Friedenthal, Arvi Haak

    Index Scriptorium Estoniae

    Jonuks, Tõnno, 1974-

    2010-01-01

    Viljandimaalt Suure-Jaani kihelkonnast Rattama talust pärit märkidega kivikettast, mille sümboleid võib pidada kaitsemaagilise taustaga märkideks. Tegemist võib olla 17. või 18. sajandil valmistatud amuletiga

  13. Centile charts of motor development in girls aged between 7.5–19.5 from the Kujawsko-Pomorskie district Centilové stupnice motorického vývoje u dívek ve věku 7,5–19,5 roku z kujavsko-pomořského kraje

    Directory of Open Access Journals (Sweden)

    Marek Napierała

    2006-02-01

    Full Text Available The aim of the research was to present motor development with the help of centile charts, where the centile curves determine particular parts of the population: 3, 10, 25, 50, 75, 90 and 97 percentile. The research was conducted in the spring of 2001. A survey of 11 803 girls aged between 7.5 and 19.5 years old, from various types of rural and urban schools of the Kujawsko-Pomorskie district, was conducted. Centile charts make it possible to observe the process of the development of the examined characteristic, to answer the question as to whether an individual is at the level which is characteristic of a certain age, and, in case of aberrations, to come to a conclusion that the process of growth is disturbed. While determining the centile position one can become familiar with the level of development of an individual against calendar individuals of the same age. The value of C50 determines the calendar age of an individual. The results of the empiric research shows that the curve of the individual development of a child "wanders" within some channels, which is quite normal and does not mean a distortion of development. Cílem výzkumů bylo představit motorický vývoj pomocí centilových stupnic, kdy centilové křivky určují jisté části populace: 3, 10, 25, 50, 75, 90 a 97 percentil. Výzkumy byly prováděny na jaře roku 2001. Týkaly se 11 803 dívek ve věku mezi 7,5 a 19,5 lety z různých typů venkovských a městských škol kujavsko-pomořského kraje. Centilové stupnice umožňují sledovat proces vývoje zkoumaných charakteristik, zodpovědět na otázku, zda se jednotlivec nachází na úrovni charakteristické pro určitý věk a – v případě odchylek – dospět k závěru, že proces růstu je narušený. Při stanovování centilové pozice je možno poznat úroveň vývoje jednotlivce ve srovnání s jednotlivci téhož kalendářního věku. Kalendářní věk jednotlivce určuje hodnota C50. Výsledky empirick

  14. 3D-Druck von Metallen als Substitution und Wettbewerb von Gussteilen?: Vortrag gehalten auf dem 26. Ledebur-Kolloquium, 27. und 28. Oktober 2016, Freiberg

    OpenAIRE

    Müller, Bernhard

    2016-01-01

    Das Fraunhofer-Institut für Werkzeugmaschinen und Umformtechnik IWU ist kompetenter Partner für anwendungsorientierte Forschung im Automobil- und Maschinenbau an den Standorten Chemnitz, Dresden, Zittau unter dem Leitthema „Ressourceneffiziente Produktion“. Die Kernkompetenzen des Instituts in der Werkzeugmaschinenentwicklung, der Umform- und Zerspanungstechnik, der Mechatronik, dem Funktionsleichtbau sowie der Systemtechnologie werden durch den Einsatz generativer Fertigungs-verfahren ergänz...

  15. Case series of 17 modified Weil's osteotomies for Freiberg's and Köhler's II AVN, with AOFAS scoring pre- and post-operatively.

    Science.gov (United States)

    Edmondson, M C; Sherry, K R; Afolayan, J; Armitage, A R; Skyrme, A D

    2011-03-01

    Treatment for metatarsal head avascular necrosis is largely conservative. For severe or refractory cases there are various surgical options. We have performed a 'modified Weil's osteotomy' of the distal metatarsal in order to manage this problem. We present the largest case series, to our knowledge, with 17 such cases. The patients were scored pre- and post-operatively using the AOFAS Forefoot scoring system. We found that this procedure provided a mean score improvement of 36 points, with a complication rate of 5.9%. We would advocate this modified osteotomy as an effective, reliable and safe treatment option. Copyright © 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.

  16. Korelace sportovní aktivity a stravovacích návyků u dětí předškolního věku a jejich rodičů The correlation of sports activity and eating habits in preschool children and their parents

    Directory of Open Access Journals (Sweden)

    Jera Zajec

    2006-02-01

    Full Text Available Cílem výzkumu bylo analyzovat sportovní aktivitu a stravovací návyky u dětí předškolního věku a jejich rodičů. Zajímala nás korelace mezi stravovacími návyky rodičů a dětí předškolního věku a sportovní aktivitou. Pro dotazování 93 rodičů tří až pětiletých dětí ze tří slovinských školek byl použit dotazník obsahující 32 otázek. Údaje byly zpracovány programem SPSS, který počítá frekvenci a kontingenční tabulky. Zjistili jsme, že výživa většiny dětí předškolního věku je pravidelná a vhodná, přestože některé pětileté dívky a tříletí chlapci mají zvýšený BMI (index tělesné hmotnosti. Stravovací návyky rodičů však nejsou ani zdaleka vzorné – přes 50 % má pouze 2 až 3 jídla denně. Přestože nebyla potvrzena žádná statisticky charakteristická korelace, výsledky ukazují, že děti, jejichž rodiče jsou sportovně aktivní, mají vhodnější výživu než děti, jejichž rodiče sportovně aktivní nejsou. Statisticky charakteristické je, že rodiče, kteří jsou sportovně aktivnější, zapojují své děti do sportu ve větší míře. Většina z nich rovněž tráví aktivně prázdniny. Domníváme se, že v době, kdy ještě podléhají vlivu rodičů a učitelů, by děti měly přijmout pozitivní přístup ke sportovně aktivnímu způsobu života a zdravé výživě, které představují základní podmínku normálního způsobu života bez zbytečných problémů způsobených škodlivými návyky a civilizačními chorobami. The aim of this research was to analyze sports activity and eating habits in preschool children and their parents. We were interested in the correlation between parents' and preschool childrens' eating habits and sports activity. A questionnaire consisting of 32 questions was used to interview 93 parents of three to five year old children from 3 Slovene kindergartens. The data was processed by the SPSS program

  17. Wpływ terapii BEMER na wybrane wskaźniki krwi w ramach procesu odnowy biologicznej po wysiłku wytrzymałościowym. Studium przypadku = Effect of BEMER therapy on selected indicators of blood in the process of wellness after exercise endurance. Case study

    Directory of Open Access Journals (Sweden)

    Mirosław Mrozkowiak

    2015-04-01

    Instytut Kultury Fizycznej, Wydział Kultury Fizycznej, Zdrowia i Turystyki, Uniwersytet Kazimierza Wielkiego, Bydgoszcz, Polska     Słowa kluczowe: terapia BEMER, wskaźniki krwi, odnowa biologiczna, wysiłek wytrzymałościowy, studium przypadku.   Keywords: BEMER therapy, blood indicators, wellness, exercise endurance, case study.   Streszczenie   Zasadniczymi naczyniami tworzącymi mikrokrążenie są naczynia włosowate. Pojedyncze naczynie włosowate ma średnicę około 6 p.m, sumaryczna powierzchnia przekroju naczyń włosowatych wynosi około 3000 cm2. Na każdy milimetr sześcienny ciała ludzkiego przypada średnio 600 naczyń włosowatych. Terapia systemem BEMR przy zastosowaniu kompleksowym lub uzupełniającym doskonali podstawowe procesy fizjologiczne, angiokinezę mikrokrążenia, doprowadzenie składników odżywczych i tlenu do komórek mięśniowych. Dzięki określonej modulacji biorytmicznej uzyskuje się synergiczny wpływ również na pierwotne i wtórne, nieco większe naczynia krwionośne. Materiał i metody. Badany mężczyzna realizujący zdrowy styl życia poddał się dwukrotnie pomiarowi wybranych wskaźników krwi i układu naczyniowego: po wysiłku wytrzymałościowym w czasie restytucji fizjologicznej oraz odnowie wspomaganej terapią BEMER. Uzyskane wyniki. Najbardziej znaczące zmiany w wybranych wskaźnikach krwi po wysiłku wytrzymałościowym zaobserwowano w: całkowitej ilości hemoglobiny najmniejsze w stężeniu jonów wodorowęglowych. Znamienne zmiany wystąpiły w okresie wczesnej odnowy we wskaźnikach: cząstkowym ciśnieniu tlenu (PO2, nasyceniu krwi tętniczej tlenem (SO2 (c, oksyhemoglobinie (O2Hb, karboksyhemoglobinie (HbCO, methemoglobinie (MeHb i hydroksyhemoglobinie (HHb.         Wnioski. Zastosowana metodyka i profil sygnału BEMER wpływa zróżnicowanie na wielkość wybranych cech krwi. Zastosowanie stymulacji BEMER w odnowie biologicznej po wysiłkach wytrzymałościowych u mężczyzn w 5

  18. Life satisfaction and the motivation to adopt physical activity in females of middle and late adulthood [Životní spokojenost a motivace k pohybové aktivitě žen ve věku střední a pozdní dospělosti

    Directory of Open Access Journals (Sweden)

    Dana Štěrbová

    2009-06-01

    multidimensional approach needs to be applied. [VÝCHODISKA: Jedním z klíčových faktorů ovlivňujících prožitkovou kvalitu období střední a pozdní dospělosti jsou fyzické zdraví a tělesné změny. Zvyšuje se ochota změnit a přijmout zdravější životní styl (včetně pohybové aktivity. Motivaci k pohybové aktivitě ovlivňuje u žen to, jak vnímají sebe sama v otázkách vzhledu. CÍLE: Studie se zaměřuje na vztah mezi subjektivně vnímanou životní spokojeností, druhem individuálně stanovených cílů a spokojeností s tělesným sebepojetím, souvisejícím s pohybovou aktivitou. METODIKA: Práce zkoumá v souboru 41 žen ve věku střední a pozdní dospělosti (40–65 let faktory ovlivňující právě motivaci k pohybové aktivitě. Byly užity metody Dotazník životní spokojenosti (DŽS a dotazník monitorující faktory tělesného sebepojetí (Monitoring v průběhu šestiměsíční pravidelné pohybové aktivity (PPA. VÝSLEDKY: Stanovení "body shape" cílů vede prostřednictvím jejich dosažení ke zvýšení spokojenosti s tělesným vzhledem. Pohybová aktivita takto orientovaných žen ovlivňuje pozitivně také vnímání jejich well being. Non body shape cíle nemají jednoznačný vztah k vnímání well being a tělesného vzhledu. Na zvýšení well being cvičících žen s non body shape cíli se podílí více faktorů. Neprokázal se jednoznačně statisticky významný vztah mezi vnímanou úrovní životní spokojenosti a spokojeností s tělesným vzhledem. ZÁVĚRY: Studie podpořila význam zvnitřněných individualizovaných cílů pro motivaci k pravidelné PA, které se promítají do prožitkové oblasti a pocitů spokojenosti s fyzickým a duševním stavem žen ve věku střední a pozdní dospělosti. Pro mapování faktorů motivace těchto žen k PA je nezbytný multidimenzionální přístup.

  19. En el entorno del teorema Kou-Ku (II)

    OpenAIRE

    Ramírez, Angel; Usón, Carlos

    2004-01-01

    Nos son tan habituales algunas cosas que no nos sorprendemos ante ellas ni nos paramos a pensar acerca de su significado profundo o sobre la maravilla de su gestación, perdida a veces en la noche de los tiempos. Considerado en abstracto, como una relación entre superficies de figuras descontextualizadas, ¡no es nada evidente el teorema de Pitágoras!, pero hay muchos problemas de tipo práctico que obligan a pasar obligatoriamente por el ángulo recto. ¿Cómo construir si no, por ejemplo, un edif...

  20. Design of a Ku band Instrumentation Synthetic Aperture Radar System

    Science.gov (United States)

    2015-10-14

    Transactions on Image Processing, 17(1), 84-93. Retrieved from IEEE Xplore Digital Library website: http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber...where L = the length of the antenna[1] m Wa Azimuth Weighting factor (0.886 used in the IEEE Derivation for the case of no weighting) Table 1...image is equal to the noise power in the signal (a Signal to Noise Ratio of 1). The formula for NEσ0, taken from an IEEE Derivation is shown below[5

  1. Bot podobný člověku

    OpenAIRE

    Dufek, Jan

    2012-01-01

    The main goal of my thesis is to create a bot for Unreal Tournament 2004 whose behaviour will be as similar as possible to human controlled players. At the beginning, I measured game play data from both humans and bots. Then, I chose one initial bot and I did five iterations of comparing bot data with humans data, selecting one difference, improving the bot with the aim to eliminate the difference and measuring data again. The successful improvements I made were removing rotations during runn...

  2. Przestrzenie publiczne i edukacja ku demokracji uczestniczącej

    Czech Academy of Sciences Publication Activity Database

    Červinková, Hana

    2014-01-01

    Roč. 5, - (2014), s. 25-33 ISSN 2082-7806 Institutional support: RVO:68378076 Keywords : engaged anthropology * participatory citizenship * education * Arendt * public spaces Subject RIV: AC - Archeology, Anthropology, Ethnology

  3. Enhanced International Space Station Ku-Band Telemetry Service

    Science.gov (United States)

    Cecil, Andrew; Pitts, Lee; Welch, Steven; Bryan, Jason

    2014-01-01

    (1) The ISS is diligently working to increase utilization of the resources this unique laboratory provides; (2) Recent upgrades enabled the use of Internet Protocol communication using the CCSDS IP Encapsulation protocol; and (3) The Huntsville Operations Support Center has extended the onboard LAN to payload teams enabling the use of standard IP protocols for payload operations.

  4. Hva´ska jeg ku' til eksamen?

    DEFF Research Database (Denmark)

    Buhl, Mie

    2005-01-01

    Lærereksamen i billedkunst er først og fremmest en bedømmelse ud fra et professionsperspektiv. Den skal demonstrere, at eksaminanden kan håndtere tre områder: billedproduktion, billedrefleksion og didaktisk refleksion i en præsentation. Men eksamen er mere end det. Den er en kommunikationssituati...

  5. Calibration of the TUD Ku-band Synthetic Aperture Radiometer

    DEFF Research Database (Denmark)

    Laursen, Brian; Skou, Niels

    1995-01-01

    The TUD Synthetic Aperture Radiometer is a 2-channel demonstration model that can simulate a thinned aperture radiometer having an unfilled aperture consisting of several small antenna elements. Aperture synthesis obtained by interferometric measurements using the antenna elements in pairs, follo...

  6. Teorie odpovědi na položku

    Czech Academy of Sciences Publication Activity Database

    Urbánek, Tomáš; Šimeček, M.

    2001-01-01

    Roč. 45, č. 5 (2001), s. 428-440 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : item response theory * classical test theory * item characteristic curve Subject RIV: AN - Psychology Impact factor: 0.195, year: 2001

  7. Globalizace začala v pravěku

    Czech Academy of Sciences Publication Activity Database

    Cílek, Václav

    2011-01-01

    Roč. 17, č. 11 (2011), s. 42-44 ISSN 1212-9607 Institutional research plan: CEZ:AV0Z30130516 Keywords : geoarchaeology * globalization * society * global change * history Subject RIV: AC - Archeology, Anthropology, Ethnology

  8. Pikler pedagogika raného věku

    OpenAIRE

    Noack, Dana

    2012-01-01

    Title: The Pikler Early Childhood Education Author: Dana Noack Department: Katedra psychologie, FF UK Supervisor: Prof. PhDr. Lenka Šulová, CSc. Abstract: The intention of this study was to explore how the parents who are familiar with the Piklerian principles use these in upbringing their children in the family in the period of early childhood. The theoretical part describes the process of socialization (with the emphasis on the preconditions for the early interaction both on the child's and...

  9. Topologie vnějšku a vnitřku v autorském herectví

    Czech Academy of Sciences Publication Activity Database

    Koubová, Alice

    2013-01-01

    Roč. 68, Suppl. 1 (2013), s. 133-143 ISSN 0046-385X R&D Projects: GA ČR(CZ) GAP401/10/1164 Grant - others:AV ČR(CZ) M300091203 Institutional support: RVO:67985955 Keywords : topology * phenomenology * phenopraxis * interiority * exteriority * (inter)acting with the inner partner * authorial acting Subject RIV: AA - Philosophy ; Religion

  10. Variability of selected indicators of physical activity in a randomized sample of the Czech population between the years 2003–2006: Results from the short and long self administered format of the IPAQ questionnaire [Variabilita vybraných indikátorů pohybové aktivity u randomizovaných souborů české populace v letech 2003–2006: Výsledky z krátké a dlouhé administrativní verze IPAQ dotazníku

    Directory of Open Access Journals (Sweden)

    Erik Sigmund

    2009-06-01

    MET–minutes/week for walking and sitting on working days. The long self administered format of the IPAQ provides more detailed results on PA. However, the value of total PA is significantly higher than that obtained using the short self administered format of the IPAQ. In order to obtain more exact data on PA, we recommend using the long self administered format of the IPAQ simultaneously with pedometer or accelerometer PA monitoring. [VÝCHODISKA: Snaha o získání celosvětově srovnatelných výsledků o úrovni pohybové aktivity (PA různých populačních skupin vyústila ve vytvoření a standardizaci Mezinárodního dotazníku o pohybové aktivitě (IPAQ. CÍLE: Hlavním cílem této studie bylo zjistit variabilitu vybraných proměnných PA ze dvou ekvivalentních forem českých administrativních verzí IPAQ dotazníku aplikovaných u randomizovaných souborů české populace v letech 2003–2006. METODIKA: Ve studii byla použita data od 11277 obyvatel České republiky (5683 žen a 5594 mužů ve věku 15–69 let. Krátká administrativní verze IPAQ byla u 2066 žen a 1976 mužů aplikována na podzim 2003 a jaře 2004. Dlouhá administrativní verze IPAQ (resp. jako součást ANEWS dotazníku byla použita u 1688 žen a 1689 mužů na podzim 2004 a jaře 2005 (resp. u 1929 žen a 1929 mužů na podzim 2005 a jaře 2006. Jednotlivé soubory účastníků byly randomizovány podle pohlaví, věku a velikosti místa bydliště v souladu s údaji Českého statistického úřadu (www.czso.cz. VÝSLEDKY: Mezi samostatně aplikovanou dlouhou verzí IPAQ a ANEWS dotazníkem (obsahujícím dlouhou verzi IPAQ nenacházíme u mužů ani žen výrazné rozdíly v MET–minut/týden v celkové PA, transportní PA, PA v zaměstnání a chůzi. U krátké verze IPAQ zaznamenáváme u mužů i žen nižší hodnoty celkové PA (p < 0,0001 než v dlouhé verzi IPAQ (resp. ANEWS dotazníku. Bez rozdílu mezi jednotlivými ekvivalentními formami IPAQ dotazníku jsou

  11. Determination of diferences in runs between boys and girls aged 5.5 Určení rozdílu v běhu mezi chlapci a dívkami ve věku 5,5 roku

    Directory of Open Access Journals (Sweden)

    Damir Karpljuk

    2005-02-01

    Full Text Available The aim of this research is to determine whether there are distinctions in runs among five and a half year old boys and girls. The research is based on studying 80 girls and 64 boys from seven kindergartens in Slovenia. The following five measurement methods have been used in our research: a 10-meter run, a 150-meter run, a 10-meter run with a flying start, 4-times 5-meter run, and a 300-meter run. The results of the t-test indicate a statistically characteristic difference among boys and girls in 300 m run test results only, that is, a method used for measuring aerobic endurance. Other motor skills results have shown that there are no statistically characteristic differences among boys and girls. It is important that sport activities for boys and girls are organized for both groups of children equally. Especially girls must take part in a variety of running exercises in order to increase their aerobic endurance. They should be encouraged to take part in a variety of games which require activating the energy component of movement. Based on the results of this research we can say that physical education (PE of preschool children should be planned regardless of sex and the PE program should be the same for both boys and girls. Cílem tohoto výzkumu je určit, zda existují odlišnosti v běhu chlapců a dívek ve věku 5,5 roku. Výzkum je založen na studii 80 dívek a 64 chlapců v sedmi mateřských školách ve Slovinsku. Bylo použito těchto pěti měřicích metod: běh na 10 metrů, běh na 150 metrů, běh na 10 metrů s letmým startem, běh 4 × 5 metrů, běh na 300 metrů. Výsledky t-testu vykázaly statisticky významný rozdíl mezi chlapci a dívkami jen v běhu na 300 metrů, což je metoda používaná pro měření aerobní vytrvalosti. Výsledky ostatních pohybových aktivit vykazují, že mezi chlapci a dívkami není žádný statisticky významný rozdíl. Je důležité, aby sportovní aktivity byly organizovány rovnom

  12. Analýza postury polohovým snímačem DTP2 u žen ve věku senescence po aplikaci cíleného cvičebního programu Posture analysis using position detector DTP2 in senescent women after the application of a targeted exercise program

    Directory of Open Access Journals (Sweden)

    Miroslava Přidalová

    2008-01-01

    Full Text Available U 3 souborů žen v mladším seniorském věku (průměrný věk 61, 63 a 66 let jsme v roce 2005, 2006 a 2007 sledovali změny v držení těla a ve tvaru páteře pomocí diagnostického přístroje DTP2 po intervenčním zásahu cíleného cvičebního programu (čínské terapeutické cvičení Chuej čchun kung. Cvičení ovlivnilo především oblast pánve, trendy naznačující zlepšení držení těla a stability nedosáhly ve všech případech statistické významnosti. Vzhledem k tomu, že technika cvičení je cíleně náročná, nesprávně provedené pozice nevedly ke zlepšení, ale projevily se nulovým efektem.Vždy byly nalezeny pozitivní změny ve smyslu zlepšení stability stoje a signifikantního posunu hrudní kyfózy k vertikále, což svědčí o zlepšení držení těla. V postavení ramen se projevila určitá rozkolísanost ve smyslu změn asymetrie ramen. Také postavení pánve reagovalo na intervenční zásahy přesuny asymetrie spinálních úhlů po 1. a 2. etapě cvičení, po 3. etapě došlo ke statisticky významnému vyrovnání levostranné asymetrie. Nalezli jsme zmenšení rozsahu titubací axiálního skeletu, což je doprovodným projevem zvýšení stability stoje. Celkově se nejlepší výsledky projevily po intervenci v roce 2007, kdy se snížil rozsah titubací ve směru osy x i y, byla zjištěna statisticky významná pozitivní změna v úpravě symetrie spina iliaca posterior superior a nalezen věcně významný trend snížení úhlových hodnot lordóz i hrudní kyfózy.Zdůvodnění těchto změn je možné najít ve zvýšeném důrazu na správné provádění technik cvičení a tím i úprav svalových dysbalancí. Subjektivní pocity seniorek byly velmi příznivé, vysoce pozitivně hodnotily pocit zlepšení stability stoje. During the years 2005, 2006, and 2007, we studied changes in the posture and spinal shape in three groups of younger female seniors (mean age 61, 63, and

  13. Mehmet Harmancı’nın Küçürek Öykülerindegündelik Kuşatma Altındaki İnsanın Varoluş Görüngüleri Existence Perspectives Of An Individual Under Daily Blockage In The Short Short Stories Of Mehmet Harmancı

    Directory of Open Access Journals (Sweden)

    Mutlu DEVECİ

    2013-03-01

    şme sürecinde değerlerini/ özünü koruyarak geleceğe taşınmalıdır. Diğerleri gibi kalmak, bireyleşememek, şey’ler dünyasında yitip gitmektir. İnsan gerçeğini tarihsel boyutuyla ele alan Mehmet Harmancı, öykülerinde, bireyin kendi oluşuna göndermede yapar. Anlam arayışı içerisindeki insanların; ölüm, aşk ve yalnızlık izlekleri etrafında eylem ve eylemsizliklerini dile getirir.Mehmet Harmancı Muhtemel Menkıbeler adlı eserinde yer alan küçürek öykülerinde, yaşamın anlamına yönelik sorgulamalarda bulunur. Türler arası geçişkenliğin dikkat çektiği bu eserde yazar, menkıbe türünün imkânlarını aşarak küçürek öykü türüne özgü bir anlatım yolu seçer. Öykülerde, şimdi’yi vareden değerler, geçmişin izdüşümünde kurulur ve gündelik kuşatma altındaki insanın varoluş görüngüleri sergilenir.Mehmet Harmancı, geleneğin izdüşümünde kurduğu Muhtemel Menkıbeler’inde moderniteyi ıskalamadan geleneği de modern olana ezdirmeden yol alır. Yazar, değerlerini yok sayarak medeniyet kurmaya çalışanlara karşı geleneği, modern dünyanın fenomenolojik temeli sayar. Bu açıdan modernite olarak kabul ettirilmeye çalışılan dünya/ yaşam yerine, temeli geleneğe dayalı bir modern dünya arzusu taşır. Muhtemel Menkıbeler’deki öykülerin pek çoğu böylesi bir ruh dünyasına aittir.Muhtemel Menkıbeler’deki öykülerde, geleneğin deneyimsel, kültürel ve nesneler belleğini başat değer olarak kabul eden yazar, yaşamın anlam arayışına yönelik sorgulamaları ile yol göstericilik özelliğini ön plana çıkarır.Çalışmada, Mehmet Harmancı’nın Muhtemel Menkıbeler adlı eserinde yer alan öyküleri analiz edilirken, menkıbe ile küçürek öykü türleri arasındaki ilişkiye dikkat çekilerek; gelenek ile modernite arasındaki insan görüngülerine yer verildi.

  14. Doktoriväitekiri terminoloogia ja tõlkimise teemal / Peeter Päll

    Index Scriptorium Estoniae

    Päll, Peeter, 1961-

    2009-01-01

    Arvustus: Tavast, Arvi. The translator is human too: a case for instrumentalism in multilingual specialised communication. Tartu : Tartu University Press, c2008. (Dissertationes philologiae estonicae Universitatis Tartuensis ; 21)

  15. Eski Türk Edebiyatında Tercüme Geleneği Ve Bu Gelenekte Mantıku’t-Tayr Tercümeleri The Tradition of Translation In Classical Ottoman Literature and Mantıku't- Tayr Translations in This Tradition

    Directory of Open Access Journals (Sweden)

    Vesile ALBAYRAK SAK

    2012-12-01

    are less or more, supporting stories are different, main ideasand subjects of these works somehow are fed from the work ofAttar,and the masnawis(poem made up of rhymed coupletshave beensuccessfully worked about being original with the efforts of the poets. Arapça "terceme" kelimesinden tercüme; "çeviri" demek olup ifadelerin bir dilden başka bir dile aktarılmasıdır. Toplumların birbirlerini tanımalarında, ilmî ve fikrî gelişmelerde köprü görevini yerine getirmiş bu faaliyet, kültürler arası etkileşimde önemli rol üstlenmiştir.Medeniyetler bir ülkeden diğerine daha çok tercüme yoluyla girer. Dînî-didaktik edebiyatın önemli bir parçası olan Attar'ın Mantıkut-Tayr'ı da edebiyatımıza tercüme yoluyla girmiştir. Tasavvufî öğretiyi allegorik bir dille, konu bütünlüğü içinde ele alan ve hikâyelerle halka indirgeyen bu eser, kaynak eser olma özelliği kazanmıştır. Mantıku't-Tayr'ın edebiyatımızda XIV. yüzyıldan başlayarak XVIII. yüzyıla kadar her yüzyılda tercümeleri ve benzerleri yazılmıştır.Gülşehrî‟nin Mantıku‟t-Tayr„ı (1317, Ali Şir Nevaî‟nin Lisânü‟t-tayr‟ı (1498/1499, İranlı Şemsî‟nin Deh Murg „u(1514, İbrahim Gülşenî‟nin Sîmurg-nâme‟si (d. 1533, Zaîfî‟nin Gülşen-i Sîmurg‟u (d. 1559, Ârifî Mehmed‟in Ravzatü‟t-Tevhîd‟i (d.1563, Kadıoğlu Şeyh Mehmed'in İnşirâhu‟s-Sadr'ı (1578 ,Şemseddin Sivâsî‟nin Gülşenâbâd‟ı (d. 1595 ve Fedâî Dede‟nin Mantıku‟l- Esrâr‟ı (d.1635 bu eserlerdendir.Bu çalışmada Mantıku‟t-Tayr tercümelerine farklı bir açıdan bakılmış,örneğe bağlı kalanlardan ziyade örnekten ayrılan şairlerin hangi çabalara giriştikleri,esere yeni bir düzen getirme ve eseri farklı açıdan yorumlama uğraşları irdelenmiştir.Örnekten isteyerek ayrılan şairlerin özellikle yardımcı hikâye seçimindeki tasarrufları konuyu dağıtmadan ele almada onlara avantaj sa

  16. Components/factors of the Czech version of the Physical Self Perception Profile (PSPP-CZ among high school students [Komponenty/faktory české verze dotazníku tělesného sebepojetí (PSPP-CZ u středoškolských studentů

    Directory of Open Access Journals (Sweden)

    Vlastimil Kudláček

    2010-12-01

    have found that students from Czech high schools have a different structure of self perception then the original PSPP population from England (Fox, 1990. Our findings correspond with findings among Flemish adults (Van de Vliet et al., 2002; Ferreira & Fox, 2007 where components of sport and condition were also loaded into one factor. There are clear, subtle differences in the structure of physical self perception as related to cultural and language differences. Findings of internal reliability and content validity suggest that the three subscales questionnaire can be used in the Czech population as a valid and reliable instrument. CONCLUSIONS: In conclusion, we can recommend using the PSPP-CZ with three scales for use among young adults for the exploration of the role of physical self-perception as a determinant of physical activity/inactivity and a healthy lifestyle.[VÝCHODISKA: Tělesné sebepojetí bylo široce zkoumáno jako určující činitel pro cvičení stejně jako jeden z prvků majících vliv na duševní zdraví a blaho (Fox, 1997. Sebepojetí je všeobecně přijímáno jako významný prostředník mezi cvičením a sebeúctou (Fox, 2000; Sonstroem, 1997. Porozumění procesům seberozvoje nabylo na důležitosti, jelikož sebeúcta a sebepojetí jsou stále významnějšími komponenty vzdělávacích, klinických a komunitních programů péče o zdraví (Ferreira & Fox, 2008. Abychom mohli prozkoumat vztahy mezi různými úrovněmi tělesných aktivit a sebepojetí, musíme k měření tělesného sebepojetí mezi českými adolescenty využít standardizované nástroje. CÍLE: Účelem této studie bylo analyzovat strukturu přeloženého dotazníku PSPP-CZ mezi populací středoškolských studentů, a to hledáním komponentů PSPP-CZ za pomoci analýzy hlavních komponentů. Dotazník tělesného sebepojetí (Physical Self Perception Profi le, PSPP na české populaci nikdy nebyl použit. METODIKA: Studie se zúčastnili st

  17. Leisure time, occupational, domestic, and commuting physical activity of inhabitants of the Czech Republic aged 55-69: Influence of socio-demographic and environmental factors [Pohybová aktivita obyvatel České republiky ve věku 55-69 let prováděná v rámci volného času, zaměstnání, v domácnosti a při přesunech: Vliv socio-demografických a environmentálních faktorů

    Directory of Open Access Journals (Sweden)

    Jana Pelclová

    2009-09-01

    domácnosti, v zaměstnání a při přesunech u obyvatel České republiky ve věku 55–69 let a za druhé zjistit, které socio-demografické a environmentální faktory mohou mít vliv na plnění doporučení k pohybové aktivitě prováděné ve volném čase, v domácnosti, v zaměstnání a při přesunech. METODIKA: Dlouhá verze mezinárodního dotazníku k pohybové aktivitě (IPAQ byla využita pro zjištění pohybové aktivity u 320 náhodně vybraných obyvatel České republiky ve věku 55–69 let. Respondenti také zodpověděli doplňkové otázky vztahující se k socio-demografickým a environmentálním faktorům. VÝSLEDKY: Plnění doporučení k středně zatěžující pohybové aktivitě bylo spojeno se základním vzděláním, věkem 55–59 let (při srovnání s věkem 65-69, bydlením v rodinném domku a nekuřáctvím, zatímco významným faktorem pro plnění doporučení k chůzi byl pouze faktor zaměstnání. Odlišné socio-demografické a environmentální faktory významně ovlivňují plnění doporučení k pohybové aktivitě při zkoumání pohybové aktivity ve volném čase, v domácnosti, v zaměstnání a při přesunech. ZÁVĚRY: Tato zjištění je potřeba brát v úvahu, zejména pokud by měla být, s ohledem na česká specifika, vytvořena úspěšná strategie na podporu pohybové aktivity u lidí předdůchodového a důchodového věku.

  18. Korteriomanditeks jagatud kinnisasja kaasomandi eseme ainukasutusse andmine ja kasutuse reguleerimine korteriühistutes parkimise korraldamise näitel : magistritöö / Tuuli Arvi ; juhendaja Kaupo Paal ; Tartu Ülikool, õigusteaduskond, eraõiguse

    Index Scriptorium Estoniae

    Arvi, Tuuli

    2018-01-01

    Korteriomandi kaasomandi eseme kasutamise regulatsiooni piiritlemisest teistest sarnastest regulatsioonidest. Korteriomandi kaasomandi eseme ainukasutusse andmisest ja selle reguleerimisest kehtivas Eesti õiguses. Kehtiva õiguse muutmise vajadusest ja võimalustest

  19. The influence of early intervention movement programs on motor skills development in preschoolers with autism spectrum disorder (case studies [Vliv raných intervenčních pohybových programů na rozvoj motorických dovedností u dětí předškolního věku s poruchou autistického spektra (případová studie

    Directory of Open Access Journals (Sweden)

    Hana Válková

    2010-06-01

    Full Text Available OBJECTIVE: The purpose of the present study was to assess the motor skills performance of preschoolers with autism spectrum disorder after eight weeks of physical activity intervention. METHODS: Participants included 5 children, 4 male and 1 female, from 62 to 81 months old, who were attending the identical special kindergarten. Both the quantitative and qualitative aspects of the children's performance were examined. With regards to the quantitative examination, participants were measured using the Movement Assessment Battery for Children (Henderson & Sugden, 1992. Qualitative results were obtained through personal observation. Each motor skills intervention program continued for eight weeks, and children were tested in both pre and post intervention phases. RESULTS: Over the course of the intervention, four of the participants improved their motor skills, while one did not. CONCLUSIONS: This study concluded that even preschool children with autism can improve their motor and social skills if they are involved in a physical activity at least twice a week. The physical activity program could improve their motor and social skills which could help them in their future development.[CÍLE: Účelem předložené studie bylo zhodnotit motorické dovednosti předškolních dětí s poruchami v autistickém spektru po osmitýdenním intervenčním programu. METODIKA: Experimentu se zúčastnilo 5 dětí, 4 chlapci a 1 dívka ve věku od 62 do 81 měsíců. Všichni navštěvovali stejnou speciální mateřskou školu. Šetření za hrnovalo jak kvantitativní, tak kvalitativní aspekty. Kvantitativní data účastníků byla měřena testem M-ABC (Baterie motorického vyšetření dětí podle Henderson a Sugden (1992, zatímco kvalitativní data byla získána pozorováním. Intervenční pohybový program trval osm týdnů a děti byly měřeny před a po intervenci. VÝSLEDKY: Čtyři děti po programu vykazovaly zlepšení dovedností, jedno d

  20. Achievement report for fiscal 1998 on Welfare Technosystem Kobe-Chuo-Ku research and development; 1998 nendo Walfare technosystem kenkyu kaihatsu (Kobeshi Chuo-ku) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Research on the transmission and management of information on those who necessitate nursing care will lead to the development of computer-aided nursing and welfare supporting systems and this in turn will help businesses who provide aged people with service they require for the enhancement of nursing care at home and at facilities for aged people to enjoy independent, unaided living. It is important to prepare liaising methods and coordinate with physicians in case of physical condition suddenly turning worse. Exchange of data at a visited place is important for a visiting nurse, and handling of information on such an occasion has to be easy and rapid to ensure high efficiency. When transmitting or receiving data on patients via PHS (personal handyphone system) or handyphone system, transmission of large-capacity data such as pictures should be avoided. In case a picture has to be transmitted, it should be compressed. ISDN (integrated services digital network) is preferred in all cases. The IEEE1394 interface is deemed to be the best for automatically transmitting as digital data the pictures etc. collected from other measuring instruments on nursing welfare and nursing assisting systems. It is necessary, however, to watch the development of digital interfaces in the future. (NEDO)

  1. Ku Klux Rising: Toward an Understanding of American Right Wing Terrorist Campaigns

    Science.gov (United States)

    2011-09-01

    leadership of Adolf Hitler and his paramilitary Sturm Abteilung (SA); even Japanese succumbed to the ideas of the Society for the Preservation of the...Jihad (Hoboken, N.J.: John Wiley & Sons, 2008). 634 Tony Kaye, “American History X,” (United States: New Line Cinema , 1998). 241 and respected...Summer 1997). 262 Kaye, Tony. “American History X.” United States: New Line Cinema , 1998. Keefer, Philip, and Norman Loayza. Terrorism, Economic

  2. Ku Band Phased Array Feed Development for Surface Water Ocean Topography Mission

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of this project is to design components essential to the development of phased arrays and phased array feeds for use in remote sensing. Specifically the...

  3. Ku I Ke Ao: Hawaiian Cultural Identity and Student Progress at Kamehameha Elementary School

    Science.gov (United States)

    Stender, Robert Holoua

    2010-01-01

    The relationship between Hawaiian cultural identity and student progress at Kamehameha Elementary School (KES) is the focal point of this study. As the student demographics continue to evolve at Kamehameha Schools, most recently with increasing numbers of children coming from orphan and indigent backgrounds, teachers want greater understanding of…

  4. Prikladnost metode spontanog emulgiranja u izradi nanoemulzija za oftalmičku primjenu

    OpenAIRE

    Pintur, Matej

    2017-01-01

    Nanoemulzije predstavljaju relativno nov terpaijski sustav s nekoliko prednosti u usporedbi s klasičnim terpijskim oblicima. Naročito su zanimljivi kao topikalni oftalmički oblici jer omogućuju bolju apsorpciju lijeka kroz barijere oka. Pripravljeno je nekoliko nanoemulzija različitih sastava metodom spontanog emulgiranja te im je ispitana veličina čestica, indeks polidisperznosti i zeta potencijal. Najbolja svojstva pokazale su nanoemulzije kod kojih je kao surfaktant korišten Cremophor EL, ...

  5. Development of KU-band waveguide break for ECR-3 ion source

    International Nuclear Information System (INIS)

    Misra, Anuraag; Prasad, R.K.; Nabhiraj, P.Y.; Mallik, C.

    2011-01-01

    This article describes the analytical design, simulation results, engineering design and testing of WR-62 waveguide break for ECR-3 ion source and it also emphasizes on the estimation of far-field radiation with the use of advanced 3D codes. (author)

  6. Strongly driven electron spins using a Ku band stripline electron paramagnetic resonance resonator

    Science.gov (United States)

    Yap, Yung Szen; Yamamoto, Hiroshi; Tabuchi, Yutaka; Negoro, Makoto; Kagawa, Akinori; Kitagawa, Masahiro

    2013-07-01

    This article details our work to obtain strong excitation for electron paramagnetic resonance (EPR) experiments by improving the resonator's efficiency. The advantages and application of strong excitation are discussed. Two 17 GHz transmission-type, stripline resonators were designed, simulated and fabricated. Scattering parameter measurements were carried out and quality factor were measured to be around 160 and 85. Simulation results of the microwave's magnetic field distribution are also presented. To determine the excitation field at the sample, nutation experiments were carried out and power dependence were measured using two organic samples at room temperature. The highest recorded Rabi frequency was rated at 210 MHz with an input power of about 1 W, which corresponds to a π/2 pulse of about 1.2 ns.

  7. Lesní řemesla v raném novověku: koncept

    Czech Academy of Sciences Publication Activity Database

    Woitsch, Jiří

    2010-01-01

    Roč. 97, č. 4 (2010), s. 337-360 ISSN 0009-0794 R&D Projects: GA AV ČR KJB900580701 Institutional research plan: CEZ:AV0Z90580513 Keywords : forest products * forest exploitation * environmental history * traditional subsistence * charcoal * potash * tar Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.343, year: 2010

  8. David Hume a věda o člověku

    Czech Academy of Sciences Publication Activity Database

    Parusniková, Zuzana

    2011-01-01

    Roč. 33, č. 2 (2011), s. 205-231 ISSN 1210-0250 Institutional research plan: CEZ:AV0Z90090514 Keywords : Hume * science of man * Newton * natural science * social sciences Subject RIV: AA - Philosophy ; Religion

  9. Radiation losses in the microwave Ku band in magneto-electric nanocomposites

    Directory of Open Access Journals (Sweden)

    Talwinder Kaur

    2015-08-01

    Full Text Available A study on radiation losses in conducting polymer nanocomposites, namely La–Co-substituted barium hexaferrite and polyaniline, is presented. The study was performed by means of a vector network analyser, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, electron spin resonance spectroscopy and a vibrating sample magnetometer. It is found that the maximum loss occurs at 17.9 GHz (−23.10 dB, 99% loss which is due to the composition of a conducting polymer and a suitable magnetic material. A significant role of polyaniline has been observed in ESR. The influence of the magnetic properties on the radiation losses is explained. Further studies revealed that the prepared material is a nanocomposite. FTIR spectra show the presence of expected chemical structures such as C–H bonds in a ring system at 1512 cm−1.

  10. The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks

    NARCIS (Netherlands)

    A. Balestrini (Alessia); D. Ristic (Dejan); I. Dionne (Isabelle); X.Z. Liu (Xiao); C. Wyman (Claire); R.J. Wellinger (Raymund); J.H.J. Petrini (John)

    2013-01-01

    textabstractSingle-ended double-strand breaks (DSBs) are a common form of spontaneous DNA break, generated when the replisome encounters a discontinuity in the DNA template. Given their prevalence, understanding the mechanisms governing the fate(s) of single-ended DSBs is important. We describe the

  11. Pokroky ve fotochemii singletového kyslíku

    Czech Academy of Sciences Publication Activity Database

    Lang, Kamil; Mosinger, Jiří; Wagnerová, Dana Marie

    2005-01-01

    Roč. 99, č. 4 (2005), s. 211-221 ISSN 0009-2770 R&D Projects: GA ČR(CZ) GA203/04/0426; GA ČR(CZ) GA203/02/1483; GA ČR(CZ) GA203/02/0420 Institutional research plan: CEZ:AV0Z40320502 Keywords : photodynamic therapy * molecular-oxygen * hydrogen -peroxide Subject RIV: CA - Inorganic Chemistry Impact factor: 0.445, year: 2005

  12. Větrání haly pro výkrm kuřat

    Czech Academy of Sciences Publication Activity Database

    Kic, P.; Zajíček, Milan

    2010-01-01

    Roč. 19, č. 5 (2010), s. 234-236 ISSN 1210-1389 Institutional research plan: CEZ:AV0Z10750506 Keywords : Broiler house * ventilation * CFD Subject RIV: GB - Machines ; Buildings for Agriculture http://library.utia.cas.cz/separaty/2013/VS/zajicek-0394117.pdf

  13. Imitatio a aemulatio ve Slovníku klementinském

    Czech Academy of Sciences Publication Activity Database

    Voleková, Kateřina

    2010-01-01

    Roč. 133, 3/4 (2010), s. 335-356 ISSN 0024-4457 R&D Projects: GA ČR GAP406/10/1140; GA MŠk(CZ) LC546 Institutional research plan: CEZ:AV0Z90610518 Keywords : Old Czech * medieval lexicography * loan word * calque * medieval Latin-Czech dictionary Subject RIV: AI - Linguistics http://lf.clavmon.cz/LF/Plné%20texty/2010/Voleková_Imitatio.pdf

  14. Modeling and validation of Ku-band signal attenuation through rocket plumes

    NARCIS (Netherlands)

    Veek, van der B.J.; Chintalapati, S.; Kirk, D.R.; Gutierrez, H.; Bun, R.F.

    2013-01-01

    Communications to and from a launch vehicle during ascent are of critical importance to the success of rocket-launch operations. During ascent, the rocket's exhaust plume causes significant interference in the radio communications between the vehicle and ground station. This paper presents an

  15. ILALOK. Dictionnaire vili–français/Mpisukulu bi kum' bi tshi vili ku tshi mputu.

    Directory of Open Access Journals (Sweden)

    P.A. Mavoungou

    2011-10-01

    Full Text Available On connaît le vif intérêt de l'Institut des Langues Locales au Kouilou pour la promotion des langues maternelles et des cultures dont elles sont le véhicule irremplaçable. La parution aux Éditions L'Harmattan du Dictionnaire vili–fran-çais en 2008 vient couronner des années d'efforts acharnés et de privations. Ce dictionnaire, consacré au civili, poursuit ainsi la tradition des ouvrages lexico-graphiques commencés par les missionnaires. Pour le civili notamment on peut citer les contributions des révérends pères Derouet (n.d. et Marichelle (1902 qui furent imprimés à la vieille imprimerie de Loango. Dans la préface du Dic-tionnaire vili–français (en abrégé DVF dans le reste du texte, le R.P. Marichelle précise que la parution de son dictionnaire vient compléter l'oeuvre du R.P. Derouet auteur du Dictionnaire français–vili. Hormis les travaux lexicographi-ques sur le civili, deux autres ouvrages ont également été publiés. Il s'agit de Proverbes et dictons du Loango en Afrique Centrale de René Mavoungou Pambou (1997 et de Parlons vili de Gervais Loembé (2005. La parution du Dictionnaire vili–français complète parfaitement bien cette série.

  16. 'Hvis vi bare ku' få fred til at passe vores arbejde...'

    DEFF Research Database (Denmark)

    Olsén, Peter

    2008-01-01

    Artiklen handler om mening og meningsskabelse i arbejdet - som forudsætning for de ansattes deltagelse og engagement i at forandre og forbedre deres arbejde. Resultater fra forskningsprojektet VISS præsenteres. 14 virksomheder arbejdede med at forbedre deres psykiske arbejdsmiljø, men mange misly...

  17. KU & Dansk Erhverv: Humanister og erhvervsliv i fælles front

    DEFF Research Database (Denmark)

    Sommerlund, Julie; Riisgaard, Louise

    2015-01-01

    Humanister besidder relevant viden, som ofte først bliver anvendt i slutningen af virksomhedernes udviklingsproces, men den tilbøjelighed skal et nyt samarbejde gøre op med, skriver Julie Sommerlund, prodekan på Københavns Universitet, og Louise Riisgaard, chefkonsulent i Dansk Erhverv....

  18. SIMULATION OF THE Ku-BAND RADAR ALTIMETER SEA ICE EFFECTIVE SCATTERING SURFACE

    DEFF Research Database (Denmark)

    Tonboe, Rasmus; Andersen, Søren; Pedersen, Leif Toudal

    2006-01-01

    A radiative transfer model is used to simulate the sea ice radar altimeter effective scattering surface variability as a function of snow depth and density. Under dry snow conditions without layering these are the primary snow parameters affecting the scattering surface variability. The model is ...

  19. Cyklus a bilance uhlíku v mokřadech

    Czech Academy of Sciences Publication Activity Database

    Čížková, Hana; Pokorný, Jan; Květ, Jan; Bauer, Václav

    2004-01-01

    Roč. 21, č. 3 (2004), s. 265-268 ISSN 1212-0731. [Agroregion 2004. České Budějovice, 06.09.2004-07.09.2004] R&D Projects: GA MŽP SM/640/18/03 Institutional research plan: CEZ:AV0Z6087904 Keywords : carbon * wetland * sustainable management Subject RIV: EH - Ecology, Behaviour

  20. Photonic integration and components development for a Ku-band phased array antenna system

    NARCIS (Netherlands)

    Marpaung, D.A.I.; Zhuang, L.; Burla, M.; Roeloffzen, C.G.H.; Noharet, Bertrand; Wang, Qin; Beeker, W.P.; Beeker, Willem; Leinse, Arne; Heideman, Rene

    2011-01-01

    In this paper the development of a phased array antenna system using a photonic beamformer is reported. The paper emphasizes on the photonic integration between two main components of the beamformer, namely the photonic beamformer chip and the electroabsorption modulator array. System level

  1. ”Sitä yritti valehdella itselleen, ettei tarvinut muuta ku se pelaaminen” : Videopelaajien kokemuksia videopeliriippuvuudesta

    OpenAIRE

    Liukkonen, Milla

    2013-01-01

    Opinnäytetyöni aiheena on videopeliriippuvuus. Tarkoitukseni on selvittää, kuinka videopelaajat kokevat videopelaamisen ja videopeliriippuvuuden sekä millaisia vaikutuksia videopelaamisella on ja on ollut. Opinnäytetyö koostuu teoreettisesta viitekehyksestä, metodologisesta osuudesta, haastatteluiden analysoinnista ja tuloksista sekä pohdinnasta. Opinnäytetyöni on ajankohtainen ja osaltaan tulevaisuuden haaste sosiaalialan työssä. Teoriaosiossani esittelen yleisesti riippuvuuden eri teori...

  2. Ku/Ka/W-band Antenna for Electronically-Scanned Cloud and Precipitation Radar

    Data.gov (United States)

    National Aeronautics and Space Administration — Previously, cloud radars such as CloudSat have been separated from precipitation radars such as TRMM (Tropical Rainfall Measurement Mission) and GPM (Global...

  3. Ze Slovníku středověké latiny: asalus a achilon

    Czech Academy of Sciences Publication Activity Database

    Šedinová, Hana

    2016-01-01

    Roč. 139, 1/2 (2016), s. 189-205 ISSN 0024-4457 Institutional support: RVO:67985955 Keywords : ancient and medieval zoology * Latin lexicography * Aristoteles * Aristoteles Latinus * Michael Scotus * Thomas of Cantimpré * Claretus * aesalon * latin names of birds Subject RIV: AI - Linguistics

  4. Ze Slovníku středověké latiny: sporcia

    Czech Academy of Sciences Publication Activity Database

    Šedinová, Hana

    2017-01-01

    Roč. 140, č. 1/2 (2017), s. 233-245 ISSN 0024-4457 Institutional support: RVO:67985955 Keywords : porcus marinus * Latin lexicography * ancient and medieval zoology * Latin names of marine animals * Bartholomaeus de Solencia dictus Claretus * Pliny the Elder * Isidorus of Sevilla * Thomas of Cantimpré Subject RIV: AI - Linguistics OBOR OECD: Specific languages

  5. Ze Slovníku středověké latiny: calopus

    Czech Academy of Sciences Publication Activity Database

    Šedinová, Hana

    2016-01-01

    Roč. 139, 3/4 (2016), s. 439-447 ISSN 0024-4457 Institutional support: RVO:67985955 Keywords : medieval Latin lexicography * ancient and medieval zoology * Physiologus * Thomas of Cantimpré * Bartholomaeus de Solencia dictus Claretus Subject RIV: AI - Linguistics

  6. Power amplifiers for the S-, C-, X- and Ku-bands an EDA perspective

    CERN Document Server

    Božanić, Mladen

    2016-01-01

    This book provides a detailed review of power amplifiers, including classes and topologies rarely covered in books, and supplies sufficient information to allow the reader to design an entire amplifier system, and not just the power amplification stage. A central aim is to furnish readers with ideas on how to simplify the design process for a preferred power amplifier stage by introducing software-based routines in a programming language of their choice. The book is in two parts, the first focusing on power amplifier theory and the second on EDA concepts. Readers will gain enough knowledge of RF and microwave transmission theory, principles of active and passive device design and manufacturing, and power amplifier design concepts to allow them to quickly create their own programs, which will help to accelerate the transceiver design process. All circuit designers facing the challenge of designing an RF or microwave power amplifier for frequencies from 2 to 18 GHz will find this book to be a valuable asset.

  7. Dítě a církev ve středověku

    Czech Academy of Sciences Publication Activity Database

    Doležalová, Eva

    2016-01-01

    Roč. 19, č. 1 (2016), s. 75-85 ISSN 0862-979X R&D Projects: GA ČR GA15-02196S Institutional support: RVO:67985963 Keywords : childhood * Church * canon law * Church administration * Czech lands * Middle Ages Subject RIV: AB - History

  8. Ku-Band Traveling Wave Slot Array Using Simple Scanning Control

    Science.gov (United States)

    Host, Nicholas K.; Chen, Chi-Chih; Volakis, John L.; Miranda, Felix A.

    2015-01-01

    This paper introduces a feeding concept aimed at simplifying the backend (phase shifters) of traditional phased arrays. As an alternative to traditional phased arrays, we employ a traveling wave array (TWA) using a single feedline whose propagation constant is controlled via a single, small mechanical movement without a need for phase shifters to enable scanning. Specifically, a dielectric plunger is positioned within a parallel plate waveguide (PPW) transmission line (TL) that feeds the TWA. By adjusting the position of the dielectric plunger within the PPW feeding the TWA, beam steering is achieved. A 20 element array is designed at 13GHz shown to give stable realized gain across the angular range of -25 deg. less than or equal to theta less than or equal to 25 deg. A proof of concept array is fabricated and measured to demonstrate and validate the concept's operation.

  9. Ku-Band radar penetration into Snow over Arctic Sea Ice

    DEFF Research Database (Denmark)

    Hendricks, Stefan; Stenseng, Lars; Helm, Veit

    is the snow/air interface, whereas radar waves interact with the variable physical properties of the snow cover on the Arctic sea ice. In addition, radar elevation measurements may vary for different retracker algorithms, which determine the track point of the scattered echo power distribution. Since accurate...... knowledge of the reflection horizon is critical for sea ice thickness retrieval, validation data is necessary to investigate the penetration of radar waves into the snow for the upcoming CryoSat-2 mission. Furthermore, the combination of both optical and RF wavelengths might be used to derive snow thickness......, if radar altimeters are capable of measuring the distance to the snow-ice interface reliably. We present the results of aircraft campaigns in the Arctic with a scanning laser altimeter and the Airborne SAR/Interferometric Radar Altimeter System (ASIRAS) of the European Space Agency. The elevation...

  10. Synopse populační genetiky evropského pravěku

    Czech Academy of Sciences Publication Activity Database

    Černý, Viktor; Hofmanová, Z.; Květina, Petr

    2017-01-01

    Roč. 69, č. 3 (2017), s. 331-360 ISSN 0323-1267 Institutional support: RVO:67985912 Keywords : population history * archaeogenetics * DNA * migration Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  11. particle size analysis of some sidewall cores from ku-1 well, offshore ...

    African Journals Online (AJOL)

    Timothy Ademakinwa

    south western Nigeria through southern Benin ... stratigraphy of the eastern margin of the ... calibrated weighing balance and the weight ...... well as the recovery life which may result in the ... encouragement during the course of this work.

  12. Computer-Aided Engineering Education at the K.U. Leuven.

    Science.gov (United States)

    Snoeys, R.; Gobin, R.

    1987-01-01

    Describes some recent initiatives and developments in the computer-aided design program in the engineering faculty of the Katholieke Universiteit Leuven (Belgium). Provides a survey of the engineering curriculum, the computer facilities, and the main software packages available. (TW)

  13. Ze Staročeského slovníku: Potejdych

    Czech Academy of Sciences Publication Activity Database

    Nejedlý, Petr; Bok, V.

    2015-01-01

    Roč. 138, 1/2 (2015), s. 149-153 ISSN 0024-4457 R&D Projects: GA ČR GAP406/10/1153 Institutional support: RVO:68378092 Keywords : Old Czech * Middle German * lexicography * lexical reconstruction * diachronic semantics Subject RIV: AI - Linguistics

  14. Validizační studie české verze dotazníku FAQ

    Czech Academy of Sciences Publication Activity Database

    Bezdíček, O.; Lukavský, Jiří; Preiss, M.

    74/107, č. 1 (2011), s. 36-42 ISSN 1210-7859 Institutional research plan: CEZ:AV0Z70250504 Keywords : questionnaire * validity * activities of daily living Subject RIV: AN - Psychology Impact factor: 0.279, year: 2011 http://www.csnn.eu/ceska-slovenska-neurologie-clanek/validizacni-studie-ceske-verze-dotazniku-faq-34140

  15. Autobiografie v českém středověku

    Directory of Open Access Journals (Sweden)

    Marie Bláhová

    2017-01-01

    Full Text Available This is an overview of the first instances of the realization of personality in Bohemia, which appear in historical literature from the 12th century and lead to the essay on medieval autobiographies. Although in the Middle Ages autobiographies were rare both in Bohemia as well as in other countries within the Latin cultural circle we are able to identify three significant autobiographies from different social environments, of different literary type and with different functions within two centuries of the late medieval period: First, the autobiography of Charles IV. This was the autobiography of a monarch written as a reflection of a Prince aimed at the author’s heirs to provide an image of the upbringing and behaviour of an exemplary monarch. The second text of this type is the autobiographical letter of former Archbishop of Prague, Jan of Jenštejn, in which the author used his own destiny to explain his political failure. At the very end of the medieval period, Christoph of Tyn, a minor nobleman who gained social success in the Emperor’s army and in diplomatic services, wrote an autobiography, where he wanted to show his descendants and future heirs how to increase the family estates legally, through honest endeavour so that they would not be ashamed of their heritage and doubt its respectable provenace. All of the authors mentioned had their own particular reasons for writing an autobiography. Naturally, all of these autobiographies are subjective, the narration is tailored to its purpose – political goals, justification of one’s failure, “substantiation” for and expression of pride in legally gained property.

  16. Současná věda o člověku

    Czech Academy of Sciences Publication Activity Database

    Černý, Viktor; Brůžek, J.

    2016-01-01

    Roč. 64, č. 5 (2016), s. 202 ISSN 0044-4812 Institutional support: RVO:67985912 Keywords : anthropology Subject RIV: AC - Archeology, Anthropology , Ethnology http://ziva.avcr.cz/files/ziva/pdf/soucasna-veda-o-cloveku.pdf

  17. Marketingová strategie pro značku Zlaté.

    OpenAIRE

    Kučerová, Jana

    2010-01-01

    Goal of the thesis Marketing strategy of brand Zlate is to evaluate newly formulated marketing strategy of the brand and after that on the basis of own questionaire to suggest future brand activities that will strenghten Zlaté brand on the Czech and Slovak markets. Theoretical part deals with marketing in general, strategies and planning and applicatin of marketing plan to individual parts of marketing mix. Practical part describes brand Zlate as such, its position in Kraft Foods, evaluation ...

  18. Prezentace zříceniny hradu Kamýku nad Vltavou

    Czech Academy of Sciences Publication Activity Database

    Durdík, Tomáš; Girsa, V.; Hanzl, M.

    2010-01-01

    Roč. 70, č. 3 (2010), 175-178,231,233-234 ISSN 1210-5538 R&D Projects: GA MK DB06P01OPP004 Institutional research plan: CEZ:AV0Z80020508 Keywords : castle * castellology * Bohemia * Kamýk nad Vltavou * medieval archaeology * architecture * monument care * presentation Subject RIV: AC - Archeology, Anthropology, Ethnology

  19. Difuze a termodynamika fosforu, uhlíku, chromu a niklu ve svarech ocelí

    Czech Academy of Sciences Publication Activity Database

    Million, Bořivoj; Stránský, K.; Michalička, Petr; Rek, A.

    2001-01-01

    Roč. 39, č. 3 (2001), s. 161-178 ISSN 0023-432X R&D Projects: GA ČR GA106/98/1367; GA AV ČR IBS2041105 Institutional research plan: CEZ:AV0Z2041904 Keywords : weld joints of steel * P, C, Cr and Ni redistribution * diffusion Subject RIV: JG - Metallurgy Impact factor: 0.343, year: 2001

  20. Kritérium neolyrického věku

    Czech Academy of Sciences Publication Activity Database

    Feinberg, Joseph Grim

    2014-01-01

    Roč. 25, č. 9 (2014), s. 10-11 ISSN 0862-657X Institutional support: RVO:67985955 Keywords : engaged literature * socialist realism * dissent * post-communism * Kundera Subject RIV: AJ - Letters, Mass-media, Audiovision

  1. Design considerations for CdTe Nanotetrapods as electronic devices. krogstrup@fys.ku.dk.

    Science.gov (United States)

    Teich-McGoldrick, S L; Bellanger, M; Caussanel, M; Tsetseris, L; Pantelides, S T; Glotzer, S C; Schrimpf, R D

    2009-11-01

    We investigate the feasibility of using CdTe nanotetrapods as circuit elements using models and simulation at multiple scales. Technology computer-aided design tools are used to simulate the electrical behavior for both metal-semiconductor field-effect transistors and junction field-effect transistors. Our results show that by varying the doping concentrations and material composition, CdTe nanotetrapods have the potential to be useful circuit elements. Monte Carlo simulations provide insight into how control over interparticle and particle-substrate interactions can lead to the directed assembly of ordered arrays of electrically gated nanotetrapods.

  2. Pravděpodobnost ve středověku

    Czech Academy of Sciences Publication Activity Database

    Saxl, Ivan

    2009-01-01

    Roč. 20, č. 2 (2009), s. 1-9 ISSN 1210-8022 R&D Projects: GA AV ČR(CZ) IAA100110502 Institutional research plan: CEZ:AV0Z10190503 Keywords : history of probability theory * problem of points * Ohri's problem * probability and talmud Subject RIV: BA - General Mathematics

  3. Ajaloolasena Tallinna linnaarhiivis 1960. aasta suvel / Jorma Ahvenainen

    Index Scriptorium Estoniae

    Ahvenainen, Jorma

    2008-01-01

    Arvi Korhoneni õpilase Jorma Ahvenaineni muljeid tööst Tallinna linnaarhiivis. Autor külastas Eestit 1960. aastal, et koguda materjale väitekirja "Der Getreidehandel Livlands im Mittelalter" jaoks

  4. THE ROLE OF INTERFERON PREPARATIONS IN THE TREATMENT OF ACUTE VIRAL RESPIRATORY INFECTIONS IN INFANTS, BABIES AND TODDLERS (RESULTS OF A MULTICENTER COMPARATIVE RANDOMIZED CLINICAL TRIAL)

    OpenAIRE

    L.V. Feklisova; A.V. Gorelov; V.P. Drinevskii; A.A. Ploskireva; E.V. Tselipanova; E.Yu. Shvets; E.V. Kanner; Yu.N. Lin'kova; E.V. Chernyaeva

    2011-01-01

    The paper analyzes the results of a comparative clinical trial of drugs recombinant human interferon alpha-2b in the dosage form of suppositories for their use in the treatment of ARVI in infants, babies and toddlers age. In accordance to the selection criteria 100 children who were hospitalized, aged from 6 months to 3 years with clinically diagnosed ARVI were included in the study. Two study groups were formed: basic, which patients within 5 days received suppositories containing taurine an...

  5. Pohřbívání ve vrcholném středověku a v novověku na Chrudimsku, Pardubicku a Kolínsku

    Czech Academy of Sciences Publication Activity Database

    Frolík, Jan

    2017-01-01

    Roč. 42, č. 1 (2017), s. 187-205 ISSN 0231-5823 R&D Projects: GA ČR GB14-36938G Institutional support: RVO:67985912 Keywords : graveyard * High Middle Ages * Early Modern Age * funeral rite * multilevel burials Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology http://hdl.handle.net/11222.digilib/136539

  6. Politické a náboženské aktualizace husitství v českých kronikách na rozhraní středověku a novověku

    Czech Academy of Sciences Publication Activity Database

    Čornej, Petr

    2017-01-01

    Roč. 20, č. 1 (2017), s. 159-179 ISSN 0862-979X R&D Projects: GA ČR(CZ) GBP405/12/G148 Institutional support: RVO:68378092 Keywords : Chronicle * history * Hussitism * Utraquism * Compactates * Early Modern Period * Middle Ages Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  7. Redistribuce hliníku a uhlíku ve svarech ocelí v intervalu teplot 500-1100 stupňů C (0,34 hm.

    Czech Academy of Sciences Publication Activity Database

    Stránský, K.; Million, Bořivoj; Foret, R.; Michalička, Petr; Rek, A.

    2003-01-01

    Roč. 76, č. 290 (2003), s. 213-221 ISSN 1429-6055. [Mezinárodní sympózium Struktura a vlastnosti konstrukčních materiálů /18./. Svratka, 25.11.2003-27.11.2003] R&D Projects: GA ČR GA106/01/0379; GA ČR GA106/01/0382 Institutional research plan: CEZ:AV0Z2041904 Keywords : aluminium and carbon diffusion * steel weldments Subject RIV: JG - Metallurgy

  8. Redistribuce hliníku a uhlíku ve svarech ocelí v intervalu teplot 500-1100 stupňů C (0,34 hm.

    Czech Academy of Sciences Publication Activity Database

    Stránský, K.; Million, Bořivoj; Foret, R.; Michalička, Petr; Rek, A.

    2003-01-01

    Roč. 76, č. 290 (2003), s. 213-216 ISSN 1429-6055. [Mezinárodní sympózium Struktura a vlastnosti konstrukčních materiálů /18./. Svratka, 25.11.2003-27.11.2003] R&D Projects: GA ČR GA106/01/0379; GA ČR GA106/01/0382 Institutional research plan: CEZ:AV0Z2041904 Keywords : aluminium and carbon diffusion * steel weldments Subject RIV: JG - Metallurgy

  9. Ječmen a ječný slad ve středověku a raném novověku v českých zemích

    Czech Academy of Sciences Publication Activity Database

    Kočár, Petr; Beneš, J.; Preusz, M.; Vaněček, Z.

    2015-01-01

    Roč. 61, č. 5 (2015), s. 153-158 ISSN 0023-5830 Institutional support: RVO:67985912 Keywords : barley * malt * macroremains * archaeobotany * archaeology * history Subject RIV: AC - Archeology, Anthropology, Ethnology http://www.kvasnyprumysl.cz/download.php?clanek=2366

  10. Utváření vesnických normových půdorysů na Olomoucku ve středověku a novověku

    Czech Academy of Sciences Publication Activity Database

    Dohnal, Martin; Škabrada, J.

    2015-01-01

    Roč. 102, č. 2 (2015), s. 199-232 ISSN 0009-0794 R&D Projects: GA ČR(CZ) GAP410/11/1287 Keywords : village * settlement * urbanism * Middle Ages * Modern Era Subject RIV: AC - Archeology, Anthropology, Ethnology

  11. Ke stému ročníku Chemických Listů

    Czech Academy of Sciences Publication Activity Database

    Holý, Petr

    2006-01-01

    Roč. 100, č. 4 (2006), s. 227-232 ISSN 0009-2770 Keywords : history and significance of the journal * notable members of editorial board Subject RIV: CC - Organic Chemistry Impact factor: 0.431, year: 2006

  12. VLIVY MÉDIÍ NA CHOVÁNÍ DĚTÍ PŘEDŠKOLNÍHO VĚKU

    OpenAIRE

    DAŇKOVÁ, Ludmila

    2008-01-01

    This baccalaureate work "Influences of Media on children's behaviour of pre-school age" treats the role and meaning of Media in the process of upbringing and education of preschool aged children. In this work, it is partly referred to possible negative effects of Media rising on children especially in consequence of showing violence, partly to unfavourable impacts rising in consequence of spending ewcessive amount of time in front of a television or other Media at the expense of other useful ...

  13. Hodnoty výskytu dyslálií v 1. ročníku

    OpenAIRE

    Štumpfová, Libuše

    2012-01-01

    Problem of the dyslalia is the main target of this graduation thesis . It's based on the value of dyslalia 1. st. school year. The teoretical part provides knowledges, which deales with this issue. It's especially based on the basic terms: communication, communication disorder, communication with the relationship to RVP PV a RVP ZV. The main part of the teoreticial part pursue of the komplex proccesing dyslalia problem (classification, symptomatology, etiology, diagnosis and therapy), graduat...

  14. Conduction mechanism in Polyaniline-flyash composite material for shielding against electromagnetic radiation in X-band & Ku band

    Directory of Open Access Journals (Sweden)

    Avanish Pratap Singh

    2011-06-01

    Full Text Available β–Naphthalene sulphonic acid (β–NSA doped polyaniline (PANI–flyash (FA composites have been prepared by chemical oxidative polymerization route whose conductivity lies in the range 2.37–21.49 S/cm. The temperature dependence of electrical conductivity has also been recorded which shows that composites follow Mott's 3D–VRH model. SEM images demonstrate that β–NSA leads to the formation of the tubular structure with incorporated flyash phase. TGA studies show the improvement in thermal stability of composites with increase in loading level of flyash. Complex parameters i.e. permittivity (ɛ* = ɛ′- iɛ″ and permeability (μ*=μ′- iμ″ of PANI-FA composites have been calculated from experimental scattering parameters (S11 & S21 using theoretical calculations given in Nicholson–Ross and Weir algorithms. The microwave absorption properties of the composites have been studied in X-band (8.2 – 12.4 GHz & Ku–Band (12.4 – 18 GHz frequency range. The maximum shielding effectiveness observed was 32dB, which strongly depends on dielectric loss and volume fraction of flyash in PANI matrix.

  15. Setkání historické epistemologie a věd o člověku

    Czech Academy of Sciences Publication Activity Database

    Dvořák, Tomáš; Balon, Jan

    2011-01-01

    Roč. 33, č. 1 (2011), s. 5-16 ISSN 1804-6347 R&D Projects: GA ČR(CZ) GAP401/11/2338 Institutional research plan: CEZ:AV0Z90090514 Keywords : historical epiostemology * philosophy of science * history of science Subject RIV: AA - Philosophy ; Religion

  16. The Medieval and Early Modern Smithy Site of Käku / Jüri Peets, Ragnar Saage, Liina Maldre

    Index Scriptorium Estoniae

    Peets, Jüri, 1952-

    2013-01-01

    Kaevandis eristati vähemalt kolme üksteise peale ehitatud sepikoja jäänuseid ajavahemikust 14.-17. sajand. Esemetest tehtud spektraalanalüüs näitas, et sepal oli hea ülevaade sulamite omadustest ja koostisest. Haruldaseim leiurühm on elevandiluust esemete katked

  17. Zemětřesení v Hrubém Jeseníku 14. 6. 2012

    Czech Academy of Sciences Publication Activity Database

    Pazdírková, J.; Zedník, Jan; Špaček, P.; Pecina, V.; Sýkorová, Z.; Krumlová, H.

    2013-01-01

    Roč. 20, 1-2 (2013), s. 202-205 ISSN 1212-6209 R&D Projects: GA MŠk LM2010008 Institutional support: RVO:67985530 Keywords : Hrubý Jeseník Mts. * felt earthquake * macroseismic magnitude * local magnitude Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  18. Drobné záhady v rejstříku Rečkovy koleje

    Czech Academy of Sciences Publication Activity Database

    Šmahel, František

    2013-01-01

    Roč. 53, č. 2 (2013), s. 11-21 ISSN 0323-0562 Institutional support: RVO:67985955 Keywords : Charles University * College of Virgin Mary * Jan Reček * Old Town of Prague * urprising of 1483 * Office of the Punishment of Mortal Sins Subject RIV: AB - History

  19. Marketingové a komunikační strategie pro značku Harley Davidson

    OpenAIRE

    Kováříková, Zuzana

    2010-01-01

    This thesis deals with the marketing and communication strategy of the Harley Davidson brand. The first chapter of the theoretical part describes marketing in general, its essence and marketing mix. The remaining two parts deal with the marketing strategy and the commercial marketing strategy. In the practical part the thesis analyses marketing and communication strategy of the Czech dealer - Harley Davidson Prague. This analysis constitutes the basis for further improvement suggestions.

  20. Radiation losses in microwave K_u region by conducting pyrrole/barium titanate and barium hexaferrite based nanocomposites

    International Nuclear Information System (INIS)

    Kaur, Talwinder; Kumar, Sachin; Narang, S.B.; Srivastava, A.K.

    2016-01-01

    Nanocomposites of substituted barium hexaferrite and barium titanate embedded in a polymer were synthesized via emulsion polymerization. The study was performed by using X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, electron spin resonance spectroscopy, a vibrating sample magnetometer and a vector network analyzer. It is found that maximum radiation loss occur at 16.09 GHz (−14.23 dB) frequency owing to the combined effect of conducting polymer, suitable dielectric and magnetic material. This suggests that prepared material is suitable for radiation losses. Micro structural study reveals the presence of all the phases of the compounds comprises composite. Benzene ring absorption band (at 1183 cm"−"1) in FT-IR spectra illustrates the presence of polymer. Surface morphology reveals the presence of array of particles encapsulated by the polymer. - Highlights: • Composites having polymer, barium titanate and hexaferrite have been successfully prepared. • Effective radiation absorption and losses have been achieved. • Magnetic properties have made an impact on shielding effectiveness.

  1. Možnosti prevence obezity dětí ve věku 12 - 15 let

    OpenAIRE

    STUDNIČKOVÁ, Marika

    2012-01-01

    At present, obesity ranks as one of the most frequent metabolic diseases caused by multiple factors. According to epidemiologic surveys, prevalence is on the increase, in particular in developed countries. It is also widely known that obesity in child age predetermines obesity in adulthood, when it is accompanied with increased risk of cardiac and metabolic complications. The present bachelor thesis engages in possibilities of prevention of obesity for children from 12 to 15 years of age. The...

  2. Identita, komunita a teorie symbolické interakce v digitálním věku

    OpenAIRE

    Bartoň, Petr

    2008-01-01

    The thesis presents a compilation about social relations and identity formation via digital technology and new media, internet in the first place. The author, with the regard to contemporary processes as globalization and rapid digital technology development, mainly relates to two topics, following the view of complexity, mutual implications, cohesion and conditionality of individual identity, interpersonal relationships and social relations, from the perspective of symbolic interaction theor...

  3. Divadlo, Bible a škola. Biblické hry v raném novověku

    Czech Academy of Sciences Publication Activity Database

    Jacková, Magdaléna

    2014-01-01

    Roč. 64, č. 4 (2014), s. 177-184 ISSN 0009-0786 R&D Projects: GA ČR GPP406/12/P823 Institutional support: RVO:68378068 Keywords : Biblical plays * early modern period * drama * Jesuits * theatre Subject RIV: AJ - Letters, Mass-media, Audiovision

  4. A new in-gas-laser ionization and spectroscopy laboratory for off-line studies at KU Leuven

    International Nuclear Information System (INIS)

    Kudryavtsev, Yu.; Creemers, P.; Ferrer, R.; Granados, C.; Gaffney, L.P.; Huyse, M.; Mogilevskiy, E.; Raeder, S.; Sels, S.; Van den Bergh, P.; Van Duppen, P.; Zadvornaya, A.

    2016-01-01

    The in-gas laser ionization and spectroscopy (IGLIS) technique is used to produce and to investigate short-lived radioactive isotopes at on-line ion beam facilities. In this technique, the nuclear reaction products recoiling out of a thin target are thermalized and neutralized in a high-pressure noble gas, resonantly ionized by the laser beams in a two-step process, and then extracted from the ion source to be finally accelerated and mass separated. Resonant ionization of radioactive species in the supersonic gas jet ensures very high spectral resolution because of essential reduction of broadening mechanisms. To obtain the maximum efficiency and the best spectral resolution, properties of the supersonic jet and the laser beams must be optimized. To perform these studies a new off-line IGLIS laboratory, including a new high-repetition-rate laser system and a dedicated off-line mass separator, has been commissioned. In this article, the specifications of the different components necessary to achieve optimum conditions in laser-spectroscopy studies of radioactive beams using IGLIS are discussed and the results of simulations are presented.

  5. Workshop o výzkumu vícejazyčnosti v Dubrovníku

    Czech Academy of Sciences Publication Activity Database

    Özörencik, Helena

    2014-01-01

    Roč. 75, č. 4 (2014), s. 366-368 ISSN 0037-7031 Institutional support: RVO:68378092 Keywords : plurilingualism * multilingualism * research * sociolinguistics * LINEE+ Subject RIV: AI - Linguistics Impact factor: 0.375, year: 2014

  6. Fyzioterapie při inkontinenci žen ve středním věku

    OpenAIRE

    SMRČKOVÁ, Kamila

    2011-01-01

    Urinary incontinence is defined as a condition which leads to inability to control the loss of urine. It represents a socio-psychological problem, which negatively influences the quality of live. In the theoretical part of the thesis there is summarized the knowledge of anatomy and kinesiology of pelvis and pelvic floor, physiology and neurophysiology of micturition, and theory of a urinary incontinence. There are also described types of urinary incontinence, their symptoms, prevention and ri...

  7. Basaltic Diatreme To Root Zone Volcanic Processes In Tuzo Kimberlite Pipe (Gahcho Kué Kimberlite Field, NWT, Canada)

    Science.gov (United States)

    Seghedi, I.; Kurszlaukis, S.; Maicher, D.

    2009-05-01

    Tuzo pipe is infilled by a series of coherent and fragmental kimberlite facies types typical for a diatreme to root zone transition level. Coherent or transitional coherent kimberlite facies dominate at depth, but also occur at shallow levels, either as dikes or as individual or agglutinated coherent kimberlite clasts (CKC). Several fragmental kimberlite varieties fill the central and shallow portions of the pipe. The definition, geometry and extent of the geological units are complex and are controlled by vertical elements. Specific for Tuzo is: (1) high abundance of locally derived xenoliths (granitoids and minor diabase) between and within the kimberlite phases, varying in size from sub-millimeter to several tens of meters, frequent in a belt-like domain between 120-200 m depth in the pipe; (2) the general presence of CKC, represented by round-subround, irregular to amoeboid-shaped clasts with a macrocrystic or aphanitic texture, mainly derived from fragmentation of erupting magma and less commonly from previously solidified kimberlite, as well as recycled pyroclasts. In addition, some CKC are interpreted to be intersections of a complex dike network. This diversity attests formation by various volcanic processes, extending from intrusive to explosive; (3) the presence of bedded polymict wall- rock and kimberlite breccia occurring mostly in deep levels of the pipe below 345 m depth. The gradational contact relationships of these deposits with the surrounding kimberlite rocks and their location suggest that they formed in situ. The emplacement of Tuzo pipe involved repetitive volcanic explosions alternating with periods of relative quiescence causing at least partial consolidation of some facies. The volume deficit in the diatreme-root zone after each eruption was compensated by gravitational collapse of overlying diatreme tephra and pre-fragmented wall-rock xenoliths. Highly explosive phases were alternating with weak explosions or intrusive phases, suggesting an external factor to control the explosive behaviour of the magma. The overall constant volatile content of the kimberlite does not explain the observed extreme change in emplacement behaviour. The facies architecture of fragmental facies dominated by vertical elements is similar to that in non- kimberlitic diatremes and indicates deposition from debris jets marking separate and repeated explosive volcanic events. In basaltic pipes, such jets are generated by phreatomagmatic explosions in the explosion chamber(s) of the root zone, causing abundant country rock fragmentation and further efficient mixture of the various particles. Phases of high explosivity formed the finely fragmented kimberlites containing a high percentage of wall-rock xenoliths, while the fluidal-shaped and partly welded texturally variable and wall-rock- poor transitional coherent facies suggest phases of repetitive, hot, and low-energy fragmentation forming kimberlite spatter. Peperite hosted in kimberlite tephra is also typically found in basaltic root zones. Time gaps in between volcanic eruptive periods are indicated by cognate pyroclasts and reworked wall-rock deposits emplaced by sporadic sedimentation events in subterranean cavities under the widening roof of the pipe. The presence of temporary caves in the root zone is proposed also by the occurrence of spherical CKC in deep- seated fragmental kimberlite and by spatter found in transitional coherent rocks. Evidence for caves was mostly preserved at deeper pipe levels advocating continuously recurring processes during the life span of Tuzo.

  8. Reconfigurable Transmission Line for a Series-Fed Ku-Band Phased Array Using a Single Feed

    Science.gov (United States)

    Host, Nicholas K.; Chen, Chi-Chih; Volakis, John L.; Miranda. Felix, A.

    2013-01-01

    The paper presents a novel approach to realize a lowcost phased array using a simple feeding mechanism. Specifically, a single coplanar stripline (CPS) transmission line is used to feed the antenna array elements. By controlling the CPS's dielectric properties using a movable dielectric plunger, scanning is achieved. Due to its simplicity, single feed, and no phase shifters, this approach leads to a dramatic reduction in cost which does not scale for larger arrays.

  9. Historical Texture Analysis of Küçük Kumla Village and Preservation Proposals

    Directory of Open Access Journals (Sweden)

    Tülay ESİN

    2013-08-01

    Full Text Available Küçük Kumla Village, which is situated in the Marmara region, Bursa City and Gemlik District embraces traces of different cultures with respect to its fertile soil character, mild climate and location. In this study, the features of the traditional neighbourhood in Küçük Kumla Village are sought to research. Through the coverage of analysis made, it is found out that the traditional texture of the village has been deteriorating gradually. Due to the fact that the varying life styles and new comfort necessities are not fulfilled by the traditional civil architectural samples, the society leads to new building production rather than traditional building usage. Another issue that results with the abandonment is the immigration to the towns and city centres from the region regarding various reasons. Not providing necessary care on the abandoned buildings tends to accelerate the deterioration process. The buildings constructs on the previous historical buildings contradicting with the original thus preventing the sense of traditional texture of the village. Through contemporary and applicable proposals provided in this study, it is predicted that historical textural deterioration of the region can be prevented and the texture of the village can be rehabilitated and preserved

  10. Poporodní blues – česká adaptace dotazníku „Maternity blues questionnaire“

    Czech Academy of Sciences Publication Activity Database

    Takács, L.; Smolík, Filip; Mlíková Seidlerová, J.; Čepický, P.; Hoskovcová, S.

    2016-01-01

    Roč. 81, č. 5 (2016), s. 355-368 ISSN 1210-7832 Institutional support: RVO:68081740 Keywords : EPDS postpartum mood * Maternity Blues Questionnaire * postnatal depression * postpartum blues * postpartum depression Subject RIV: AN - Psychology

  11. Kuća u Splitskom statutu – građenje, održavanje, rušenje

    Directory of Open Access Journals (Sweden)

    Josip Belamarić

    2015-12-01

    Full Text Available It can be said that the town statute of Split and the stipulations concerning the everyday life in this medieval town are not characterized by the aim to create an ideal city and, in this, they are far from the long-range urban planning contained in the statute of Dubrovnik. The fact that less than five per cent of the stipulations in the statute of Split relate to urban planning ought to be understood as indicating that the town, set in Diocletian’s Palace and determined by its structures, had already been defined to a large extent and that it functioned well and fulfilled the needs of its inhabitants. Thirty chapters of the statute deal with different aspects of the development of medieval Split and its everyday maintenance. This article focuses on the relationship between the local government and private property, that is, with the cases of private spaces being transformed into public spaces and the ‘ritualistic erasures’, that is, the demolition of houses whose owners committed treason and broke the law. This phenomenon of demolition as setting example was not limited to medieval Split but was recorded in other Dalmatian communes (in Omiš and Dubrovnik as late as the eighteenth century and this discussion of it is based on the examination of a wider set of primary sources.

  12. Vývoj doliny Bielej vo vzťahu ku genéze Belianskej jaskyně

    Czech Academy of Sciences Publication Activity Database

    Bella, P.; Bosák, Pavel; Pruner, Petr; Glazek, J.; Hercman, H.

    2011-01-01

    Roč. 63, č. 4 (2011), s. 369-387 ISSN 0016-7193 R&D Projects: GA AV ČR IAA300130701 Institutional research plan: CEZ:AV0Z30130516 Keywords : geomorphology * denundation chronology * planation surface * river valley * cave morphology * speleogenesis * paleomagnetism * U-series dating * pollen analysis * Belianské Tatry Mts. (Slovakia) Subject RIV: DB - Geology ; Mineralogy

  13. Výtvarná hra v předškolním věku

    OpenAIRE

    KOČÍ, Veronika

    2013-01-01

    This thesis deals with the characteristic of preschool age and findings in the field of the developmental psychology. It defines foundations of Art Education and art games, which can be exercised in conditions of nursery schools, namely in accordance with valid regulations for preschool education in Czech Republic. The practical part implements selected art activities in practice and aims to support the development of creativity, abilities and skills of preschool children as it is defined in ...

  14. Minulost a budoucnost Elektronického slovníku staré češtiny

    Czech Academy of Sciences Publication Activity Database

    Vajdlová, Miloslava

    2011-01-01

    Roč. 48, 1/2 (2011), s. 29-34 ISSN 1212-5326 R&D Projects: GA ČR GAP406/10/1153; GA MŠk(CZ) LC546 Institutional research plan: CEZ:AV0Z90610518 Keywords : Old Czech * electronic dictionary * electronic lexicography Subject RIV: AI - Linguistics

  15. Sekvestrace uhlíku smrkovým porostem (PICEA ABIES (L.) KARST.) v oblasti Drahanské vrchoviny

    Czech Academy of Sciences Publication Activity Database

    Světlík, J.; Krejza, Jan; Menšík, L.; Pokorný, Radek; Mazal, P.; Kulhavý, J.

    2016-01-01

    Roč. 61, č. 1 (2016), s. 42-53 ISSN 0322-9688 Institutional support: RVO:67179843 Keywords : carbon * sequestration * Norway spruce * above- and below-ground biomass * allometric relationships * biomass expansion factors * forest floor * soil * Drahanská vrchovina upland * Czech Republic Subject RIV: EH - Ecology, Behaviour

  16. Náplavový kužel na okraji pouštní pánve

    Czech Academy of Sciences Publication Activity Database

    Mikuláš, Radek

    2005-01-01

    Roč. 84, č. 6 (2005), s. 306-306 ISSN 0042-4544 R&D Projects: GA AV ČR(CZ) KSK3012103 Institutional research plan: CEZ:AV0Z30130516 Keywords : alluvial fan * desert settings * China Subject RIV: DB - Geology ; Mineralogy http://www.vesmir.cz/files/file/fid/3653/aid/6314

  17. Controls and measurements of KU engine test cells for biodiesel, SynGas, and assisted biodiesel combustion

    Science.gov (United States)

    Cecrle, Eric Daniel

    This thesis is comprised of three unique data acquisition and controls (CDAQ) projects. Each of these projects differs from each other; however, they all include the concept of testing renewable or future fuel sources. The projects were the following: University of Kansas's Feedstock-to-Tailpipe Initiative's Synthesis Gas Reforming rig, Feedstock-to-Tailpipe Initiative's Biodiesel Single Cylinder Test Stand, and a unique Reformate Assisted Biodiesel Combustion architecture. The main responsibility of the author was to implement, develop and test CDAQ systems for the projects. For the Synthesis Gas Reforming rig, this thesis includes a report that summarizes the analysis and solution of building a controls and data acquisition system for this setup. It describes the purpose of the sensors selected along with their placement throughout the system. Moreover, it includes an explanation of the planned data collection system, along with two models describing the reforming process useful for system control. For the Biodiesel Single Cylinder Test Stand, the responsibility was to implement the CDAQ system for data collection. This project comprised a variety of different sensors that are being used collect the combustion characteristics of different biodiesel formulations. This project is currently being used by other graduates in order to complete their projects for subsequent publication. For the Reformate Assisted Biodiesel Combustion architecture, the author developed a reformate injection system to test different hydrogen and carbon monoxide mixtures as combustion augmentation. Hydrogen combustion has certain limiting factors, such as pre-ignition in spark ignition engines and inability to work as a singular fuel in compression ignition engines. To offset these issues, a dual-fuel methodology is utilized by injecting a hydrogen/carbon monoxide mixture into the intake stream of a diesel engine operating on biodiesel. While carbon monoxide does degrade some of the desirable properties of hydrogen, it acts partially like a diluent in order to prevent pre-ignition from occurring. The result of this mixture addition allows the engine to maintain power while reducing biodiesel fuel consumption with a minimal NOx emissions increase.

  18. Sledování exprese metalothioneinu u transgenních rostlin tabáku

    Czech Academy of Sciences Publication Activity Database

    Diopan, V.; Baloun, J.; Adam, V.; Macek, Tomáš; Havel, L.; Kizek, R.

    2007-01-01

    Roč. 123, 9/10 (2007), s. 325-327 ISSN 1210-3306 R&D Projects: GA MŠk 1M06030 Institutional research plan: CEZ:AV0Z40550506 Keywords : phytoremediation * metallothionein * transgenic plants * tobacco * heavy metals Subject RIV: EI - Biotechnology ; Bionics

  19. Původ obsidiánové suroviny v pravěku Čech

    Czech Academy of Sciences Publication Activity Database

    Burgert, Pavel; Přichystal, A.; Prokeš, L.; Petřík, J.; Hušková, S.

    2016-01-01

    Roč. 68, č. 2 (2016), s. 224-234 ISSN 0323-1267 R&D Projects: GA ČR GA15-16963S Institutional support: RVO:67985912 Keywords : chipped industry * obsidian * Bohemia * Neolithic * Upper Palaeolithic * geochemistry * provenance Subject RIV: AC - Archeology, Anthropology, Ethnology

  20. Restaurování halštatského koflíku s uchem

    Czech Academy of Sciences Publication Activity Database

    Svobodová, Ljuba

    2011-01-01

    Roč. 13, č. 1 (2011), s. 4-8 ISSN 1212-4168 Institutional research plan: CEZ:AV0Z80020508 Keywords : Hallstatt period * archaeological ceramics * restoration Subject RIV: AC - Archeology, Anthropology, Ethnology

  1. Hrátky s kostmi. Astragaly jako doklady her v mladém pravěku

    Czech Academy of Sciences Publication Activity Database

    Nývltová Fišáková, Miriam; Parma, D.

    2014-01-01

    Roč. 19, č. 1 (2014), s. 113-122 ISSN 1805-918X Institutional support: RVO:68081758 Keywords : Bronze Age * astragalus * games Subject RIV: AC - Archeology, Anthropology, Ethnology http://digilib.phil.muni.cz/handle/11222.digilib/129974

  2. Karneval a karnevalizace v raném novověku a možnosti interpretace

    Czech Academy of Sciences Publication Activity Database

    Havelka, Tomáš

    2014-01-01

    Roč. 11, č. 22 (2014), s. 51-66 ISSN 1214-7915 R&D Projects: GA ČR(CZ) GB14-37038G Institutional support: RVO:67985955 Keywords : carnival * carnivalisation * early modern culture * Bohemia * literature Subject RIV: AA - Philosophy ; Religion

  3. Lepidological review on the fish fauna of the Kučlín locality (Upper Eocene, Czech Republic)

    Czech Academy of Sciences Publication Activity Database

    Přikryl, Tomáš

    2011-01-01

    Roč. 67, 3/4 (2011), s. 149-156 ISSN 0036-5343 Institutional research plan: CEZ:AV0Z30130516 Keywords : fossil fish fauna * Osteichthyes * scales * morphology * Paleogene * Upper Eocene * Upper Eocene (Czech Republic) Subject RIV: DB - Geology ; Mineralogy http://www.nm.cz/publikace/archiv-en.php?id=4&rok=67&kcislu=3-4&f_=Show

  4. Circuital characteristics and radiation properties of an UWB electric-magnetic planar antenna for Ku-band applications

    NARCIS (Netherlands)

    Haider, S.N.; Caratelli, D.; Yarovoy, A.G.

    2013-01-01

    A planar, directive antenna with large fractional bandwidth is introduced in this paper. A detailed discussion on the proposed antenna topology and its architecture is reported. The proposed element is a combination of a patch and a loop radiator. A proper combination of the electric field radiator

  5. Svahové deformace v oblasti Keprníku, Hrubý Jeseník

    Czech Academy of Sciences Publication Activity Database

    Roštínský, Pavel

    2010-01-01

    Roč. 25, č. 25 (2010), s. 120-123 ISSN 0514-8057. [Stav geomorfologických výzkumů v roce 2010 /11./. Praha, 11.05.2010-13.05.2010] Institutional research plan: CEZ:AV0Z30860518 Keywords : metamorphic rocks * rock-fall * debris flow Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://www.geology.cz/zpravy/obsah/2009

  6. P2-35: The KU Facial Expression Database: A Validated Database of Emotional and Conversational Expressions

    Directory of Open Access Journals (Sweden)

    Haenah Lee

    2012-10-01

    Full Text Available Facial expressions are one of the most important means of nonverbal communication transporting both emotional and conversational content. For investigating this large space of expressions we recently developed a large database containing dynamic emotional and conversational expressions in Germany (MPI facial expression database. As facial expressions crucially depend on the cultural context, however, a similar resource is needed for studies outside of Germany. Here, we introduce and validate a new, extensive Korean facial expression database containing dynamic emotional and conversational information. Ten individuals performed 62 expressions following a method-acting protocol, in which each person was asked to imagine themselves in one of 62 corresponding everyday scenarios and to react accordingly. To validate this database, we conducted two experiments: 20 participants were asked to name the appropriate expression for each of the 62 everyday scenarios shown as text. Ten additional participants were asked to name each of the 62 expression videos from 10 actors in addition to rating its naturalness. All naming answers were then rated as valid or invalid. Scenario validation yielded 89% valid answers showing that the scenarios are effective in eliciting appropriate expressions. Video sequences were judged as natural with an average of 66% valid answers. This is an excellent result considering that videos were seen without any conversational context and that 62 expressions were to be recognized. These results validate our Korean database and, as they also parallel the German validation results, will enable detailed cross-cultural comparisons of the complex space of emotional and conversational expressions.

  7. The Analysis of Average Diameter of Erythrocytes in Children of Early Age with Pneumonia and Acute Respiratory Viral Infections

    Directory of Open Access Journals (Sweden)

    S. S. Shevchenko,

    2015-01-01

    Full Text Available Development of inflammatory bronkholegochny process in children is followed by the permanent changes in system of an eritron aggravating finally the phenomena of a hypoxia of bodies and fabrics. Work purpose: studying of average diameter of erythrocytes at children of early age, patients with pneumonia and ARVI. Determination of average diameter of erythrocytes was carried out by a diffraction method on identical structure of chaotic objects at 36 children with pneumonia and at 41 children with a ARVI aged from 4 months till 3 years. The control group was made by 20 almost healthy children of the same age. During the sharp period of a disease the average diameter of erythrocytes was authentically increased both at pneumonia, and at a ARVI. Reliable difference of these indicators when comparing a toxic syndrome at pneumonia and a ARVI is revealed. Thus, at children of early age, patients with pneumonia and ARVI, in dynamics of a disease the natural changes of average diameter of erythrocytes having differential and diagnostic and predictive value are revealed.

  8. Vliv porostů trav na změny v obsahu vápníku, hořčíku, dusíku a organické hmoty v lesní půdě přesunuté na odlesněnou plochu se zátěží polutantů

    Czech Academy of Sciences Publication Activity Database

    Tůma, Ivan; Fiala, Karel; Holub, Petr

    2001-01-01

    Roč. 14, - (2001), s. 235-240. ISBN 80-7157-297-7 R&D Projects: GA AV ČR KSK6005114 Institutional research plan: CEZ:AV0Z6005908 Keywords : grass stands * soil acidification * deforested sites Subject RIV: EF - Botanics

  9. Efficacy of Chistonos for Children in the Treatment and Prevention of Acute Respiratory Viral Infections in Preschool Children

    Directory of Open Access Journals (Sweden)

    I.V. Dahaieva

    2016-02-01

    Full Text Available The complex of treatment of acute respiratory viral infection (ARVI, acute rhinitis in 43 preschool children was supplemented by endonasal irrigations of Chistonos for children, which is a dosing gel spray containing sea salt, β-carotene, aloe and calendula extracts. A marked local symptomatic relief was registered, as well as an acceleration of the regression of inflammatory changes in the nasal cavity and a significant decrease in the number of complications after acute respiratory disease. Prophylactic use of the product in the preseason allowed to decrease the ARVI (including influenza morbidity rate and to reduce the incidence of the severe form of the disease.

  10. Tartu keemiafirma kolimine Jõgevamaale viibib / Väinu Rozental

    Index Scriptorium Estoniae

    Rozental, Väinu, 1957-

    2004-01-01

    Mayeri Industries juhid Imre Freiberg ja Peeter Laurson selgitavad, miks pole ettevõte lubatud tähtajaks tootmist Tartust Tabiverre üle viinud. Lisa: Tartu Florast sai Mayeri Industries. Diagramm: Mayeri prognoosib kasumi kahekordistumist

  11. Njakroshjusofilija, i ne tolko / Aleksandr Sokoljanski

    Index Scriptorium Estoniae

    Sokoljanski, Aleksandr

    2003-01-01

    Kõige eredamad teatrielamused 2003.a. Pikemalt Eimuntas Nekroshiuse lavastustest Kristionas Donelaitise (1714-1780) poeemi "Aastaajad" järgi. Samas ka A. Shapiro lavastusest Tallinna Linnateatris - "Isad ja pojad", kunstnik A. Freibergs

  12. Saving silver in screen printed solar cell processing

    OpenAIRE

    Florian Buchholz

    2017-01-01

    This presentation was part of the Workshop: Recycling, reuse and resource efficiency: New solutions for a PV circular economy - Results from the projects CABRISS and ECOSOLAR. The workshop was organized within Freiberg Silicon Days 2017.

  13. PV Life Cycle Analysis

    OpenAIRE

    Karsten Wambach

    2017-01-01

    This presentation was part of the Workshop: Recycling, reuse and resource efficiency: New solutions for a PV circular economy - Results from the projects CABRISS and ECOSOLAR. The workshop was organized within Freiberg Silicon Days 2017.

  14. Geochronology and magnetic fabrics of the Altenberg-Teplice granite porphyry: implications for emplacement style of a caldera ring dike

    Czech Academy of Sciences Publication Activity Database

    Tomek, Filip; Žák, J.; Svojtka, Martin

    2016-01-01

    Roč. 46 (2016), s. 39-40 E-ISSN 1434-7512. [Late Paleozoic magmatism in the Erzgebirge / Krušné hory: Magma genesis, tectonics, geophysics, and mineral deposits : abstracts. 11.11.2016-12.11.2016, Freiberg] Institutional support: RVO:67985831 Keywords : porphyry * magnetic fabrics * geochronology * Altenberg-Teplice Subject RIV: DB - Geology ; Mineralogy http://tu-freiberg.de/sites/default/files/media/institut-fuer-geologie-718/pdf/fog_volume_46.pdf

  15. Piirivalve orkestri 11 unustamatut päeva Austraalias / Tanel Saarmann

    Index Scriptorium Estoniae

    Saarmann, Tanel

    2008-01-01

    Oma reisist Piirivalve Orkestriga Austraaliasse räägivad Arvi Miido, Raul Mäe ja Jüri Kalve. Lisa: Väljavõtted artiklist Adelaide'i kohalikus väliseesti ajalehes Virgats, 5. mai 2008 ; Mis on tattoo?

  16. Karmid mängud / Kristel Raesaar

    Index Scriptorium Estoniae

    Raesaar, Kristel

    2000-01-01

    Tüli puiduärimehega maksis Hansapangale üle 100 miljoni. Lisa: ühed faktid, mitu tõlgendust - Hansapanga kreedidirektor Aivar Rehe, ECT tegevjuhi Arvi Schilfi ja laenu varjamises süüdistatud Hansapanga endise väliskaubanduse finantseerimise osak. juhataja Mait Kolditsa nägemus ECT laenuraha kadumisega seotud sündmustest

  17. SA Virumaa Muuseumid Viru-Nigula pastopraadimuuseum / Fredi-Armand Tomps, Leila Pärtelpoeg, Annes Hermann

    Index Scriptorium Estoniae

    Tomps, Fredi-Armand, 1928

    2008-01-01

    12 ill.; fotod: Sven Arbet, Arvi Kriis; pastoraadimajas on renoveeritud esimesed ruumid, s.h. saal (arhitekt Fredi Tomps, sisearhitekt Leila Pärtelpoeg); sohva koopia on valminud 1990-ndate algul L. Pärtelpoja jooniste järgi Tartu kunstikooli mööbliosakonna õpilaste diplomitööna Annes Hermanni juhendamisel

  18. Kas teha konteinerklass? / Raivo Juurak

    Index Scriptorium Estoniae

    Juurak, Raivo, 1949-

    2011-01-01

    Koolikorraldusest ja koolidesse vastuvõtust Soomes, Saksamaal ja Inglismaal. Arvamusi avaldavad Soomes õpetajana töötavad Tiiu Jürisson ja Arvi Nikkarev, pikaajalise Soomes töötamise kogemusega TLÜ lektor Anu Carlsson ning Saksamaal Hessenis õpetajana töötav Kadri Heller

  19. Estconil jagati taas Stalkereid / Jüri Kallas

    Index Scriptorium Estoniae

    Kallas, Jüri

    2006-01-01

    Ulmeauhind Stalker 2006 - tõlkeromaan: Lukjanenko, Sergei. Peegelduste labürint / tõlkinud Tanel Rõigas; antoloogia või tõlkekogu: Arvi Nikkarevi koostatud antoloogia "Aphra"; tõlkejutt: Vance, Jack. Puukoi; algupärane raamat: Hargla, Indrek. French ja Koulu; algupärane jutt: Belials, Veiko. Wereke, wereke, ega sa wesi...

  20. Kas mäletad ? / Sirje Jõgi

    Index Scriptorium Estoniae

    Jõgi, Sirje

    2004-01-01

    21. nov. 2004 tähistati Melbourne'is Välis-Eesti Päeva, Kodu-Eesti probleemidest kõneles Arvi Vainomäe; järgnenud Taevo Vaikma korraldatud üritusel "Kas mäletad ?" esitasid eri ajastute estraadilaule-tantse laulugrupp "Kirjud Vestid", rahvatantsurühm "Eiderattad" ja üksikesinejad

  1. Mõtteid raamatust / Koost. Heigi Aaviste

    Index Scriptorium Estoniae

    1995-01-01

    Aut.: Maire Liivamets, Paul Luhtein, Paul-Eerik Rummo, Maksim Gorki, Johannes Semper, R.Descartes, Valmar Adams, Lilli Promet, Paul Rummo, Cicero, Honoré de Balzac, Aleksandr Pushkin, Epikuros, Debora Vaarandi, Arvi Siig, Helene Johani, Juhan Smuul, Friedebert Tuglas

  2. Hõivatute edetabelisse jõudis kolm meest Ugalast / Tea Raidsalu

    Index Scriptorium Estoniae

    Raidsalu, Tea

    2009-01-01

    Postimehe nädalalõpulisa "Arter" kõige hõivatumate näitlejate loendis on Ugalast Tanel Ingi, Arvo Raimo ja Arvi Mägi. Andmeid nimekirja koostamiseks andsid teatrite trupijuhid. Ugala näitlejate kaalukamate rollide väljaselgitamist kommenteerib kirjandustoimetaja Helle Leppik

  3. Rossendorf Beamline at ESRF (ROBL-CRG). Bi-annual report 2009/2010

    International Nuclear Information System (INIS)

    Scheinost, Andreas C.; Baehtz, Carsten

    2011-01-01

    The Rossendorf Beamline (ROBL) - located at BM20 of the European Synchrotron Radiation Facility (ESRF) in Grenoble, France - is in operation since 1998. This 7th report covers the period from January 2009 to December 2010. In these two years, 67 peer- reviewed papers have been published based on experiments done at the beamline, more than in any biannual period before. Six highlight reports have been selected for this report to demonstrate the scientific strength and diversity of the experiments performed on the two end-stations of the beamline, dedicated to Radiochemistry (RCH) and Materials Research (MRH). The beamtime was more heavily overbooked than ever before, with an acceptance rate of only 25% experiments. We would like to thank our external proposal review members, Prof. Andre Maes (KU Leuven, Belgium), Prof. Laurent Charlet (UJF Grenoble, France), Dr. Andreas Leinweber (MPI Metallforschung, Stuttgart, Germany), Prof. David Rafaja (TU Bergakademie Freiberg, Germany), Prof. Dirk Meyer (TU Dresden, Germany), who evaluated the inhouse proposals in a thorough manner, thereby ensuring that beamtime was distributed according to scientific merit. The period was not only characterized by very successful science, but also by intense work on the optics upgrade. In spring 2009, a workshop was held at ROBL, assembling beamline experts from German, Spanish and Swiss synchrotrons, to evaluate the best setup for the new optics. These suggestions was used to prepare the call for tender published in July 2009. From the tender acceptance in November 2009 on, a series of design review meetings and factory acceptance tests followed. Already in July 2010, the first piece of equipment was delivered, the new double-crystal, double-multilayer monochromator. The disassembly of the old optics components started end of July, 2011, followed by the installation of the new components. As of December 2011, the new optics have seen the first test beam and thorough hot commissioning will

  4. Rossendorf Beamline at ESRF (ROBL-CRG). Bi-annual report 2009/2010

    Energy Technology Data Exchange (ETDEWEB)

    Scheinost, Andreas C; Baehtz, Carsten [eds.

    2011-07-01

    The Rossendorf Beamline (ROBL) - located at BM20 of the European Synchrotron Radiation Facility (ESRF) in Grenoble, France - is in operation since 1998. This 7th report covers the period from January 2009 to December 2010. In these two years, 67 peer- reviewed papers have been published based on experiments done at the beamline, more than in any biannual period before. Six highlight reports have been selected for this report to demonstrate the scientific strength and diversity of the experiments performed on the two end-stations of the beamline, dedicated to Radiochemistry (RCH) and Materials Research (MRH). The beamtime was more heavily overbooked than ever before, with an acceptance rate of only 25% experiments. We would like to thank our external proposal review members, Prof. Andre Maes (KU Leuven, Belgium), Prof. Laurent Charlet (UJF Grenoble, France), Dr. Andreas Leinweber (MPI Metallforschung, Stuttgart, Germany), Prof. David Rafaja (TU Bergakademie Freiberg, Germany), Prof. Dirk Meyer (TU Dresden, Germany), who evaluated the inhouse proposals in a thorough manner, thereby ensuring that beamtime was distributed according to scientific merit. The period was not only characterized by very successful science, but also by intense work on the optics upgrade. In spring 2009, a workshop was held at ROBL, assembling beamline experts from German, Spanish and Swiss synchrotrons, to evaluate the best setup for the new optics. These suggestions was used to prepare the call for tender published in July 2009. From the tender acceptance in November 2009 on, a series of design review meetings and factory acceptance tests followed. Already in July 2010, the first piece of equipment was delivered, the new double-crystal, double-multilayer monochromator. The disassembly of the old optics components started end of July, 2011, followed by the installation of the new components. As of December 2011, the new optics have seen the first test beam and thorough hot commissioning will

  5. Radioactivity in sheep meat, cow and goat milk, 1988-2004; Radioaktiv forurensning i sauekjoett, ku- og geitemelk, 1988-2004

    Energy Technology Data Exchange (ETDEWEB)

    Gjelsvik, R.

    2005-09-01

    The report summarizes the results of monitoring 137Cs in sheep, cow and goats milk from selected farms in 2004 and long-term effects from 1988-2004.The results give a basis for this years slaughter forecasts in 2004 and give information about the levels, variation and long-term effects of 137Cs in some of Norway's most important food chains. Sheep classification zones made clean feeding necessary wholly or partially in 34 municipalities in 2004. Effective ecological half-times for 137Cs in goat milk from Nord-Trondelag and Oppland were 9-10 years for the period 1989-2004. Effective ecological half-times for 137Cs in cow milk were 7 years in farms from Nordland county and 10 years in farms from Oppland county. Concentration of 137Cs in sheep meat from Oppland county measured in 1989-2004, showed an estimated effective ecological half-time of 10 years for ewes and 11 years for lambs. (Author)

  6. K výskytu druhu Potamogeton praelongus ve Frýdlantském výběžku

    Czech Academy of Sciences Publication Activity Database

    Kaplan, Zdeněk

    36-37, - (2006), s. 39-40 ISSN 0231-9705 R&D Projects: GA ČR GA206/04/0786 Institutional research plan: CEZ:AV0Z60050516 Keywords : floristics * distribution * endangered species Subject RIV: EF - Botanics

  7. Hradiště v Moravičanech Na Soutoku v raném středověku

    Czech Academy of Sciences Publication Activity Database

    Šlézar, Pavel

    -, č. 314 (2017), s. 103-116 ISSN 1212-1134 R&D Projects: GA ČR GA15-22658S Keywords : fortified settlement * graveyard * Middle Ages * Moravičany * Moravia Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  8. Har rød solhatt (Echinacea purpurea), råmelk fra ku (Bovine colostrum) eller c-vitamin effekt på forkjølelse?

    OpenAIRE

    Vassbotn, Liv Jorunn

    2009-01-01

    This literature review examines if Echinacea purpurea, Bovine colostrum or Vitamin C has an effect on common cold infections. Effect is defined in this article as prevention, reduction of symptoms or decrease in duration of disease. The 9 clinical studies and 2 meta- analysis included in this literature review has not found statistically significant result by use of Echinacea purpurea, Bovine colostrums or Vitamin C versus placebo during common cold infection. Therefore I cannot recommend the...

  9. Rozchod rodičů a jeho dopad na děti v adolescentním věku

    OpenAIRE

    VÁVROVÁ, Lenka

    2011-01-01

    The focus of this bachelor thesis is on parental separation and divorce and their impact on adolescent children. Based on literature research, the theoretical part defines the basic terms related to the current family and cohabitation issues. It also focuses on the possibilities of child upbringing (sole custody, shared custody, joint custody). The practical part presents the findings about how children experience their parents? separation, whether and how parents talk to their children about...

  10. Zkušenosti pravidelných kuřáků s odvykáním kouření

    OpenAIRE

    DIEPOLDOVÁ, Lucie

    2016-01-01

    This diploma thesis deals with aspects of breaking the habit of smoking. My thesis consists of theoretical and practical part. The theoretical part is divided into three main chapters: smoking, impact of smoking and breaking of the smoking habit. I also defined the history of smoking, type of tobacco consuming, addiction to tobacco, treatments of the addiction, negative aspects of smoking etc. Practical part consists of quantitative research through questionnaires. The aim of my thesis was to...

  11. Narativa u jedinců s dysartrií a anartrií ve školním věku

    OpenAIRE

    Trávníčková, Marcela

    2007-01-01

    Logopádie beschaftigt sich mit dem Kommunikationsprozess, der durch die geschriebene, gesprochene, pantomimische Sprache realisiert wird. Es existieren aber auch andere Kommunikationsvarianten, die uns gesamt dazu berechtigen, die Kommunikation als Lebensprinzip sogar Naturprinzip zu akzeptieren. Deshalb ist das Thema dieser Diplomarbeit: Narrative bei Personen mit Dysartrie und Anartrie im jungeren Schulalter. Theoretischer Teil arbeitet mit Fachbůchern und Artikeln und konzentriert sich nic...

  12. Afektivna topologija: Maks Rajnhard kuća (1992 Pitera Ajzenmana / The Affective Topology: Max Reinhardt House (1992 by Peter Eisenman

    Directory of Open Access Journals (Sweden)

    Željka Pješivac

    2013-06-01

    Full Text Available This paper reconsiders the relation between digitally modeled architecture and a body in front of it or in it. Such a relationship investigates production or better affection of haptic space in a viewer’s body, and thus dislocation of the discursive function of the human subject and vision. Developing this thesis through historical, comparative and analytical method, the objective of this paper is to elaborate contemporary cognitions of affect and affectation (in the era of digital media and modifications of a body perception in interaction with digital technology manifested through architectural design. The starting point is based on the philosophical views of Henri Bergson, Gilles Deleuze, Felix Guattari and Mark Hansen. Attention is moving from poststructuralistic semiology and theory of text toward a new phenomenology.

  13. Básník Ladislav Novomeský v hledáčku Státní bezpečnosti (1948–1950)

    Czech Academy of Sciences Publication Activity Database

    Doskočil, Zdeněk

    2017-01-01

    Roč. 20, č. 37 (2017), s. 37-63 ISSN 1211-8184 R&D Projects: GA ČR(CZ) GA16-02046S Institutional support: RVO:67985963 Keywords : Ladislav Novomeský * State Security * Slovak Bourgeois Nationalism * Czech-Slovak relations * Communist Party of Slovakia * Political Trials Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  14. Social Self-Government Is a Dream I Haven't Given Up On. Interview with Petr Uhl, by Petr Kužel

    Czech Academy of Sciences Publication Activity Database

    Kužel, Petr; Uhl, P.

    2017-01-01

    Roč. 1, č. 2 (2017), s. 169-184 ISSN 2570-7485 Institutional support: RVO:67985955 Keywords : Petr Uhl * May 68 * Intellectual Association of the Left * Revolutionary Youth Movement * Charter 77 Subject RIV: AA - Philosophy ; Religion

  15. Ku koopetycji w sporcie. Wyzwania dla rynku o wysokiej konkurencji = Towards coopetition in sport. Challenges for the market of high competition.

    Directory of Open Access Journals (Sweden)

    Aneta Stosik

    2016-09-01

      One of the most important aspects of leading service organizations is searching for advantages and creative solutions. Organizations look for new qualitative assets, create new values for their clients and create processes on the basis of their key competences. That kind of approach enable to improve organizational effectiveness and economic efficiency but more important to gain competitive advantages. Sport and recreational services develops extremely dynamically. Changes of lifestyle and social norms impose on clients non-standard actions and looking for individualized services. Personal training became a response for specific client’s needs. Personal trainers help not only to shape bodies and build fitness for clients, but also provide professional and individualized services by their competency complementarity. To achieve this personal trainers need to look for support and cooperation with other specialists and trainers in the whole customer service process. Building competitive advantages by cooperation with competitors cause a situation where personal trainers have to cooperate and compete with them at the same time - this phenomenon is called co-opetition and becomes more often a standard in recreational services.

  16. Opavané jako vychovatelé šlechty z českých zemí na prahu novověku (1550-1620)

    Czech Academy of Sciences Publication Activity Database

    Holý, Martin

    2009-01-01

    Roč. 107, č. 4 (2009), s. 241-255 ISSN 0037-6833 R&D Projects: GA AV ČR KJB800150801 Institutional research plan: CEZ:AV0Z80150510 Keywords : nobility * preceptors * private education Subject RIV: AB - History

  17. Politické násilí a koncept failed state - komparace Iráku a Somálska

    OpenAIRE

    Nemešová, Lucie

    2011-01-01

    There is recently growing interest, and also the political and academic debate connected to it, in the so called failed states. The problem of state failure in some of the world regions was securitized, particularly after the 9/11 terrorist attacks, and the failed states began being understood as a security threat by the international community. This change in perception of the failed states reflects the concerns that such states' areas could serve as a "safe havens" of various terrorist grou...

  18. K finální podobě Řecko-staroslověnského slovníku-indexu

    Czech Academy of Sciences Publication Activity Database

    Čermák, Václav

    2007-01-01

    Roč. 76, č. 1 (2007), s. 39-46 ISSN 0037-6736. [Církevněslovanská lexikografie 2006. Praha, 26.10.2006-27.10.2006] R&D Projects: GA AV ČR IAA9092403 Institutional research plan: CEZ:AV0Z90920516 Keywords : Dictionary * Old Church Slavonic * Old Greek Subject RIV: AI - Linguistics

  19. Lyžování dětí předškolního věku

    OpenAIRE

    Coufalová, Dana

    2010-01-01

    The bachelor thesis deals with skiing of preschool children. Selecting the most appropriate equipment, procedures and teaching methods. In the practical part I focused on finding the parents' views on teaching skiing in the ski schools and the teaching by their own force. The reasons which lead them to select one of these two possibilities of teaching. What they are seeing the advantages or disadvantages of vice versa. Key words: ski school, downhill skiing, education of skiing for children, ...

  20. Znovunalezené Dodatky k Příručnímu slovníku jazyka českého

    Czech Academy of Sciences Publication Activity Database

    Dvořáčková, Věra

    2013-01-01

    Roč. 5, č. 1 (2013), s. 47-54 ISSN 1803-9448 Institutional support: RVO:68378092 Keywords : lexicography * Addenda to Desk Dictionary of the Czech Language * the Institute of the Czech Language Subject RIV: AI - Linguistics

  1. New research results from the smithy site of Käku in 2013-2014 / Ragnar Saage, Jüri Peets, Elis Tiidu, Liina Maldre

    Index Scriptorium Estoniae

    2015-01-01

    Praeguste teadmiste kohaselt on tegemist 14.-17. sajandisse kuuluva muistisega, kus on leitud nelja üksteisele järgneva sepikoja konstruktsioonid. Välitööde kõige olulisem tulemus oli kõige vanema sepikoja järgu eristamine eelviimasest

  2. Vliv reklamy na děti školního a předškolního věku

    OpenAIRE

    Jantošová, Nicole

    2014-01-01

    Advertising is everywhere around us. Every day a large amount of commercials and adverts is influencing us regardless of the fact whether it is from TV, the internet or magazines. We also can see advertising in shops and on the streets. Children are becoming a popular target of traders and therefore this thesis is focused on the impact of advertising on children. The goal of the thesis is to analyse the impact of advertising on children attending the primary school and the nursery school, the...

  3. Diagnostika psychosociálního klimatu porodnice – konstrukce a psychometrická evaluace dotazníku KLI-P

    Czech Academy of Sciences Publication Activity Database

    Takács, L.; Smolík, Filip; Sněhotová, J.; Horáková Hoskovcová, S.

    2013-01-01

    Roč. 57, č. 1 (2013), s. 73-91 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Institutional support: RVO:68081740 Keywords : psychosocial climate * maternity hospital * evaluation of health care Subject RIV: AN - Psychology Impact factor: 0.292, year: 2013

  4. Východné rozšírenie a politika EÚ v oblasti energetiky: smerom ku spoločnej európskej energetickej politike?

    Directory of Open Access Journals (Sweden)

    Matúš Mišík

    2012-12-01

    Full Text Available Eastern Enlargement and the EU Energy Policy: towards Common European Energy Policy?The paper analyses the development of the EU energy policy since the beginning of the European integration and argues that the eastern enlargement and two gas crises in 2006 and 2009 have crucially impacted its evolution. Originally, the ES/EU dealt primarily with the formation and liberalisation of internal energy market, however after 2004 the focus has shifted towards issues of energy security and external energy relations in general. The paper uses the spillover concept to analyse the development of the EU energy policy. It argues that the development of internal energy market was caused by a spillover from internal market as such, while the progress in the area of energy policy after the eastern enlargement was an outcome of efforts to achieve energy security; efforts that resulted in further spillover effects in areas such as diversification, external energy relations or efficiency. The paper thus claims that common European energy policy in its internal and external dimensions started to evolve gradually after the Eastern enlargement.

  5. Výzkum představivosti u dětí mladšího školního věku

    OpenAIRE

    Kutilová, Sandra

    2010-01-01

    SUMMARY: The aim of this thesis "Research the imagination of children younger school age" was primarily to determine the level of spatial skills among pupils of the 4th and 5th grade of primary school. This work compares and shows the level of surface and spatial imagination in two planes - theoretical (quantitative test - 2D imagination, 3D imagination) and practical (manipulation puzzles - Tangram, Soma cube).

  6. Dialektologické aspekty Slovníku pomístních jmen na Moravě a ve Slezsku

    Czech Academy of Sciences Publication Activity Database

    Čižmárová, Libuše

    2012-01-01

    Roč. 6, č. 1 (2012), s. 117-130. ISBN 978-83-7654-182-2. ISSN 1898-9276. [Aktualne problemy dialektologii słowiańskiej. Poznań-Obrzycko, 12.05.2010-15.05.2010] R&D Projects: GA ČR GA405/08/0703 Keywords : dialect ology * onomastics * anoikonyms * dictionary of minor place names Subject RIV: AI - Linguistics

  7. Confidence in and beliefs about first-year engineering student success : Case study from KU Leuven, TU Delft, and TU Graz

    NARCIS (Netherlands)

    de Laet, Tinne; Broos, Tom; van Staalduinen, J.P.; Ebner, Martin; Langie, G.; van Soom, Carolien; Schepers, Wim

    2017-01-01

    This paper explores the confidence starting first-year engineering students have in being successful in the first study year and which study-related behaviour they believe to be important to this end. Additionally, this paper studies which feedback these students would like to receive and compares

  8. Popis osobnosti pachatele trestného činu vloupání dle Cloningerova dotazníku temperamentu a charakteru

    Czech Academy of Sciences Publication Activity Database

    Polišenská, Veronika

    2009-01-01

    Roč. 53, č. 6 (2009), s. 545-555 ISSN 0009-062X R&D Projects: GA ČR GA406/07/0261 Institutional research plan: CEZ:AV0Z70250504 Keywords : personality * Cloninger * burglary Subject RIV: AN - Psychology Impact factor: 0.226, year: 2009

  9. Chata z doby římské od rybníka Martiňáku, Praha 9-Dolní Počernice

    Czech Academy of Sciences Publication Activity Database

    Mácalová, Michaela

    Suppl. 101, - (2016), s. 24-25 ISSN 1211-992X. [Archeologické výzkumy v Čechách 2015. Praha, 05.04.2016-06.04.2016] Institutional support: RVO:67985912 Keywords : Roman period * hut * dog burial Subject RIV: AC - Archeology, Anthropology, Ethnology

  10. Ze slovníku Vysokoškolského uměleckého souboru Univerzity Karlovy (nos autem - ucho vlakem)

    Czech Academy of Sciences Publication Activity Database

    Jílková, Lucie

    2004-01-01

    Roč. 87, č. 5 (2004), s. 225-232 ISSN 0027-8203 R&D Projects: GA AV ČR KJB9061304 Institutional research plan: CEZ:AV0Z9061902 Keywords : slang * word formation * vocabulary Subject RIV: AI - Linguistics

  11. Příklad predikce rozložení uhlíku ve svarových spojích ocelí

    Czech Academy of Sciences Publication Activity Database

    Řeháčková, L.; Dobrovská, J.; Dobrovská, V.; Pilous, V.; Million, Bořivoj; Stránský, K.

    2005-01-01

    Roč. 86, č. 308 (2005), s. 181-186 ISSN 1429-6055. [20. mezinárodní sympozium Metody hodnocení stuktury a vlastností materiálů. 051207-051209, Ustroň-Jaszowiec] R&D Projects: GA ČR(CZ) GA106/04/1006; GA ČR(CZ) GA106/04/0949; GA ČR(CZ) GA106/03/0264 Institutional research plan: CEZ:AV0Z20410507 Keywords : prediction * carbon redistribution * steel weldments Subject RIV: JG - Metallurgy

  12. Predikce rozložení uhlíku ve svarových spojích ocelí

    Czech Academy of Sciences Publication Activity Database

    Řeháčková, L.; Dobrovská, J.; Dobrovská, V.; Pilous, V.; Million, Bořivoj; Stránský, K.

    2005-01-01

    Roč. 86, č. 308 (2005), s. 175-180 ISSN 1429-6055. [20. mezinárodní sympozium Metody hodnocení stuktury a vlastností materiálů. 051207-051209, Ustroň-Jaszowiec] R&D Projects: GA ČR(CZ) GA106/04/1006; GA ČR(CZ) GA106/04/0949; GA ČR(CZ) GA106/03/0271 Institutional research plan: CEZ:AV0Z20410507 Keywords : carbon diffusion * steel weldments

  13. Stabilita a trendy vývoje inteligence u dětí ve věku 3 - 15 let

    Czech Academy of Sciences Publication Activity Database

    Jelínek, Martin; Klimusová, Helena; Blatný, Marek

    2003-01-01

    Roč. 47, č. 5 (2003), s. 392-404 ISSN 0009-062X R&D Projects: GA AV ČR IAA8025004 Institutional research plan: CEZ:AV0Z7025918 Keywords : intelligence * stability * development Subject RIV: AN - Psychology Impact factor: 0.232, year: 2003

  14. Analýza faktorů selhání chlapců adolescentního věku

    OpenAIRE

    Klinger, Roman

    2009-01-01

    In my diploma thesis I deal with social failure of adolescent boys. The work is divided into theoretic and practical part. In the theoretic part I describe in detail the term of adolescence, the identity of juveniles, socializing of these adolescents and social failure. The chapter Adolescence is focused on the development of this period, talks on physical change, emotional development etc. In the chapter Identity we can find the definition of identity and relation features of adolescents. In...

  15. Proměny v produkci a recepci řeči v pozdním věku

    Czech Academy of Sciences Publication Activity Database

    Müllerová, Olga

    2007-01-01

    Roč. 16, - (2007), s. 107-115 ISSN 1230-2287 R&D Projects: GA ČR GA405/03/0133; GA ČR GA405/06/1468 Institutional research plan: CEZ:AV0Z90610518 Keywords : communication * production of speech * reception of speech * pronunciation * intonation Subject RIV: AI - Linguistics

  16. Propagation Measurement on Earth-Sky Signal Effects for High Speed Train Satellite Channel in Tropical Region at Ku-Band

    Directory of Open Access Journals (Sweden)

    Abdulmajeed H. J. Al-Jumaily

    2015-01-01

    Full Text Available Recent advances in satellite communication technologies in the tropical regions have led to significant increase in the demand for services and applications that require high channel quality for mobile satellite terminals. Determination and quantification of these requirements are important to optimize service quality, particularly in the Malaysian region. Moreover, the tests on current satellite propagation models were carried out at temperate regions whose environmental characteristics are much different from those in Malaysia. This difference renders these propagation models inapplicable and irrelevant to tropical regions in general. This paper presents the link characteristics observations and performance analysis with propagation measurements done in tropical region to provide an accurate database regarding rain and power arches supply (PAs attenuations in the tropics for mobile scenarios. Hence, an extension for improving the performance assessment and analysis of satellite/transmission has been achieved. The Malaysia propagation measurement for mobile scenario (Malaysia-PMMS enables first-hand coarse estimation and attenuation analysis, because the attenuation resulting from rain and PAs becomes easily amenable for measurement. Parallel to that, the measured attenuation has been compared with that of the simulated output at noise floor level. The underlying analytical tool is validated by measurements specific at tropical region, for dynamic model of mobile satellite links operating at higher than 10 GHz.

  17. Časně eneolitická výšinná lokalita na Okrouhlíku v Praze-Libni

    Czech Academy of Sciences Publication Activity Database

    Dobeš, Miroslav

    2016-01-01

    Roč. 23, č. 1 (2016), s. 15-31 ISSN 0231-6390 Institutional support: RVO:67985912 Keywords : Early Eneolithic * hilltop settlement * Okrouhlík Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  18. Signály úzkosti v kresbě dětí mladšího školního věku

    OpenAIRE

    ČERNÁ, Adéla

    2017-01-01

    This bachelor thesis deals with the extent of using drawing techniques as indicative screening method for detecting increased level of anxiety and anxiousness of primary school children. The basic terminology such as anxiousness, anxiety and fear are defined in the theoretical part. The thesis focuses on the issue of anxiety and anxiousness of children attending primary schools as well as on using children's drawings as a diagnostic tool with an orientation on human body drawing. Signs of anx...

  19. Větrná mapa České republiky pro výšku 100 m nad zemským povrchem

    Czech Academy of Sciences Publication Activity Database

    Hanslian, David; Hošek, Jiří; Chládová, Zuzana; Pop, Lukáš

    2014-01-01

    Roč. 67, č. 4 (2014), s. 97-105 ISSN 0026-1173 Institutional support: RVO:68378289 Keywords : wind map * average wind speed * boundary layer model * PIAP model * VAS/WAsP model * WAsP model * Czech Republic Subject RIV: DG - Athmosphere Sciences, Meteorology http://www.chmi.cz/files/portal/docs/reditel/SIS/casmz/2014_4.pdf

  20. Hlasy bez rámů. Krajské nakladatelství Růže ve věku konkrétní iracionality

    Czech Academy of Sciences Publication Activity Database

    Košnarová, Veronika

    2014-01-01

    Roč. 20, č. 3 (2014), s. 315-339 ISSN 1210-7050 Institutional support: RVO:68378068 Keywords : arts policy * regional culture * Czech literature * publishing house Růže Subject RIV: AJ - Letters, Mass-media, Audiovision

  1. Skladování energie – téma v hledáčku AV ČR

    Czech Academy of Sciences Publication Activity Database

    Bendová, Magdalena; Hrubý, Jan; Chomát, Miroslav; Zima, Patrik

    -, č. 2 (2016), s. 7-9 ISSN 1210-9525. [Technology Perspectives for Energy Storage. Praha, 30.11.2015] Grant - others:AV ČR(CZ) StrategieAV21/3 Program:StrategieAV Institutional support: RVO:61388998 ; RVO:67985858 Keywords : energy storage * renewable energy sources * strategy AV21 initiative Subject RIV: CF - Physical ; Theoretical Chemistry

  2. Monomeric immunoglobulin E stabilizes FcepsilonRIalpha from the human basophil cell line KU812 by protecting it from natural turnover

    DEFF Research Database (Denmark)

    Jensen, Bettina Margrethe; Hansen, Jens Bo; Dissing, S

    2003-01-01

    The high affinity IgE receptor (FcepsilonRI) on mast cells and basophils is up-regulated by its own ligand IgE; however, the mechanism is unknown.......The high affinity IgE receptor (FcepsilonRI) on mast cells and basophils is up-regulated by its own ligand IgE; however, the mechanism is unknown....

  3. Dítě předškolního věku a morální hodnoty

    OpenAIRE

    JURČOVÁ, Alena

    2015-01-01

    This thesis deals with the possibility of developing the moral behavior of preschool children. The work is divided into two parts theoretical and practical. The theoretical part is focused on the moral development of preschool age and the comparing the stage of development with the educational requirements which are identified in the framework educational programmes for preschool education. The practical part is devoted to the realization and the reflection of the long-term integrated unit wh...

  4. Metody detekce středu interferenčního proužku v interferometrii nízké koherence

    Czech Academy of Sciences Publication Activity Database

    Pikálek, Tomáš; Fořt, Tomáš; Buchta, Zdeněk

    2014-01-01

    Roč. 59, č. 8 (2014), s. 220-223 ISSN 0447-6441 R&D Projects: GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01 Institutional support: RVO:68081731 Keywords : low-coherence interferometry * interference fringe center detection techniques * surface analysis Subject RIV: BH - Optics, Masers, Lasers

  5. Imobilizované fotosenzitizátory singletového kyslíku a jejich účinek na mikroorganismy

    Czech Academy of Sciences Publication Activity Database

    Rychtáriková, Renata; Kuncová, Gabriela

    2009-01-01

    Roč. 103, č. 10 (2009), s. 800-813 ISSN 0009-2770 R&D Projects: GA ČR(CZ) GA203/06/1244 Institutional research plan: CEZ:AV0Z40720504 Keywords : photosensitizer * singlet oxygen * reactive oxygen species Subject RIV: CE - Biochemistry Impact factor: 0.717, year: 2009

  6. Analiza metroloških karakteristika uređaja za optičku digitalizaciju stomatoloških CAD/CAM sistema

    OpenAIRE

    Trifković, Branka V.

    2012-01-01

    Razvoj i unapređenje metoda 3D digitalizacije u proteklih četrdeset godina, omogućio je da se ideja o primeni digitalnog otiska u stomatologiji pretvori u stvarnost. Za razliku od konvencionalnog otiska koji predstavlja kopiju zuba i okolnih tkiva u negativu, 3D digitalizacija je postupak u okviru koga se vrši prikupljanje podataka u vidu koordinata – tačaka i obavla njihovo prevođenje u digitalnu formu. Razlike u radnim principima postupaka 3D digitalizacije predstavljale su p...

  7. Koliko studenti koriste kartične proizvode i kako doživljavaju marketinšku komunikaciju izdavatelja kartica

    OpenAIRE

    Ozretić Došen, Đurđana; Vajda, Bernarda

    2011-01-01

    Za marketinške stručnjake u kartičnom poslovanju studentska populacija predstavlja vrlo zanimljiv i važan tržišni segment. Usluge i proizvodi koje izdavatelji kartica nude studentima kreiraju se radi privlačenja korisnika koji će steći navike dugoročnog, lojalnog korištenja odabrane marke kartice, tj. i nakon završetka akademskog obrazovanja. U radu je opisano provedeno izviđajno istraživanje o kartičnim proizvodima namijenjenim studentskoj populaciji u Republici Hrvatskoj. Istraživano je kol...

  8. Jaký je význam vápníku pro léčbu osteoporózy?

    Czech Academy of Sciences Publication Activity Database

    Žák, J.; Šenholdová, Z.; Navrátil, Tomáš

    2007-01-01

    Roč. 8, č. 2 (2007), s. 94-100 ISSN 1212-6721 R&D Projects: GA MPO 1H-PK/42; GA ČR GA203/07/1195 Institutional research plan: CEZ:AV0Z40400503 Keywords : calcium * osteoporosis Subject RIV: CF - Physical ; Theoretical Chemistry

  9. Tvorba elektronického Slovníku pomístních jmen na Moravě a ve Slezsku

    Czech Academy of Sciences Publication Activity Database

    Čižmárová, Libuše

    2010-01-01

    Roč. 51, č. 1 (2010), s. 79-93 ISSN 1211-4413 R&D Projects: GA ČR GA405/08/0703 Institutional research plan: CEZ:AV0Z90610518 Keywords : Dictionary of Moravian and Silesian Anoikonyms * electronic dictionary * digital database * generating maps Subject RIV: AI - Linguistics

  10. Depresivní symptomatika ve věku 12-15 let - mezipohlavní rozdíly a další souvisosti

    Czech Academy of Sciences Publication Activity Database

    Fráňová, Lenka

    2004-01-01

    Roč. 48, č. 6 (2004), s. 510-522 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : adolescence * global self - esteem * depressive symptoms Subject RIV: AN - Psychology Impact factor: 0.209, year: 2004

  11. Developing and Testing a New Measurement Instrument for Documenting Instrumental Knowledge Utilisation: The Degrees of Knowledge Utilization (DoKU) Scale

    Science.gov (United States)

    Bøllingtoft Knudsen, Søren

    2018-01-01

    Focus on evidence-based policymaking is greater than ever, and public spending on evaluations is rising. A primary merit of these expenditures is that politicians actually use new knowledge instrumentally--to influence and inform decision making. Nevertheless, we know surprisingly little about whether and how research-based knowledge is utilised.…

  12. Osvojování českých slovesných tvarů v raném věku

    Czech Academy of Sciences Publication Activity Database

    Smolík, Filip

    2002-01-01

    Roč. 46, č. 5 (2002), s. 450-461 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : developmental psychology * psycholinquistics * acquisition of language Subject RIV: AN - Psychology Impact factor: 0.190, year: 2002

  13. Analýza růstové schopnosti kuřecího hybrida ve vybraném podniku

    OpenAIRE

    MASÁROVÁ, Anna

    2015-01-01

    The bachelor thesis deals with the use of potential growth ability of commercial broiler Ross 308.27,100 chickens were enrolled in the summer batch and it was finished after 36 days of fattening. 26,500 chickens were in the winter batch and it was finished at the age of 37 days. Although hybrids in the summer batch were one day younger, they achieved better fattening parameters. Their average final live weight was 140 g higher and feed consumption per 1 kg weight gain was 14 g lower.The morta...

  14. Ergonomie řešení nábytku a pokoje pro dítě na vozíčku

    OpenAIRE

    Kotas, Petr

    2015-01-01

    Thesis deals with furniture and interior ergonomics for the physically handicapped children in wheelchair. Provides information about the problems of disability and physically disabled children needs. Thesis defines the requierements for creating an amiable interior and barrier-free furniture. The thesis goal is design furniture and room for physically disabled child and define physically disabled child outreach possibilities.

  15. Kvalita života dítěte předškolního věku

    OpenAIRE

    Čechová, Iva

    2008-01-01

    The thesis "A pre-school child's quality of life". Focus on a child using the philosophy of education as your point of view based on the timeless testament of J.A.Komenský and thoughts of present specialists who's dealing with child's education within philosophy, pedagogy and psychology. Its aim is to identify the ethical aspect of an adult in a child's education as a factor in the understanding of basic human values. The background theory is dedicated to phenomenon's - home, love and respons...

  16. Implementation of a Novel Low-Cost Low-Profile Ku-Band Antenna Array for Single Beam Steering from Space

    Science.gov (United States)

    Host, Nicholas K.; Chen, Chi-Chih; Volakis, John L.; Miranda, Felix A.

    2013-01-01

    Phased array antennas afford many advantages over traditional reflector antennas due to their conformality, high aperture efficiency, and unfettered beam steering capability at the price of increased cost and complexity. This paper eliminates the complex and costly array backend via the implementation of a series fed array employing a propagation constant reconfigurable transmission line connecting each element in series. Scanning can then be accomplished through one small (less than or equal to 100mil) linear motion that controls propagation constant. Specifically, each element is fed via a reconfigurable coplanar stripline transmission line with a tapered dielectric insert positioned between the transmission line traces. The dielectric insert is allowed to move up and down to control propagation constant and therefore induce scanning. We present a 20 element patch array design, scanning from -25 deg. less than or equal to theta less than or equal to 21 deg. at 13GHz. Measurements achieve only10.5 deg. less than or equal to theta less than or equal to 22 deg. scanning due to a faulty, yet correctable, manufacturing process. Beam squint is measured to be plus or minus 3 deg. for a 600MHz bandwidth. This prototype was improved to give scanning of 3.5 deg. less than or equal to theta less than or equal to 22 deg. Cross-pol patterns were shown to be -15dB below the main beam. Simulations accounting for fabrication errors match measured patterns, thus validating the designs.

  17. Černá smrt v českých zemích ve středověku

    OpenAIRE

    Gojda, Jan

    2009-01-01

    When they saw the sea horizon Messinští mast Genoese galleys, which came from the business offices in the Crimea, certainly had no idea that they proclaim the most shattering pandemic in the history of the continent, black Pandemic of death. The disease, which affected all corners of Europe, which itself has disappeared After four centuries as mysteriously as she appeared, and todaymany question marks hanging. The more we know about the Black Death, the less traditional truthsremain in the li...

  18. Bezdězsko - Dokesko v pravěku a laténské sídliště v Oknech

    Czech Academy of Sciences Publication Activity Database

    Dreslerová, Dagmar; Waldhauser, J.; Abraham, V.; Kočár, Petr; Křivánek, Roman; Meduna, Petr; Sádlo, Jiří

    2013-01-01

    Roč. 65, č. 3 (2013), s. 535-573 ISSN 0323-1267 R&D Projects: GA AV ČR IAAX00050801 Institutional support: RVO:67985912 ; RVO:67985939 Keywords : prehistoric landscape * marginal areas * La Tène period * archaeobotany * boreal forest * sediments * the Kobyly group Subject RIV: AC - Archeology, Anthropology, Ethnology; EF - Botanics (BU-J)

  19. Measurement of Precipitation in the Alps Using Dual-Polarization C-Band Ground-Based Radars, the GPM Spaceborne Ku-Band Radar, and Rain Gauges

    Directory of Open Access Journals (Sweden)

    Marco Gabella

    2017-11-01

    Full Text Available The complex problem of quantitative precipitation estimation in the Alpine region is tackled from four different points of view: (1 the modern MeteoSwiss network of automatic telemetered rain gauges (GAUGE; (2 the recently upgraded MeteoSwiss dual-polarization Doppler, ground-based weather radar network (RADAR; (3 a real-time merging of GAUGE and RADAR, implemented at MeteoSwiss, in which a technique based on co-kriging with external drift (CombiPrecip is used; (4 spaceborne observations, acquired by the dual-wavelength precipitation radar on board the Global Precipitation Measuring (GPM core satellite. There are obviously large differences in these sampling modes, which we have tried to minimize by integrating synchronous observations taken during the first 2 years of the GPM mission. The data comprises 327 “wet” overpasses of Switzerland, taken after the launch of GPM in February 2014. By comparing the GPM radar estimates with the MeteoSwiss products, a similar performance was found in terms of bias. On average (whole country, all days and seasons, both solid and liquid phases, underestimation is as large as −3.0 (−3.4 dB with respect to RADAR (GAUGE. GPM is not suitable for assessing what product is the best in terms of average precipitation over the Alps. GPM can nevertheless be used to evaluate the dispersion of the error around the mean, which is a measure of the geographical distribution of the error inside the country. Using 221 rain-gauge sites, the result is clear both in terms of correlation and in terms of scatter (a robust, weighted measure of the dispersion of the multiplicative error around the mean. The best agreement was observed between GPM and CombiPrecip, and, next, between GPM and RADAR, whereas a larger disagreement was found between GPM and GAUGE. Hence, GPM confirms that, for precipitation mapping in the Alpine region, the best results are obtained by combining ground-based radar with rain-gauge measurements using a geostatistical approach. The GPM mission is adding significant new coverage to mountainous areas, especially in poorly instrumented parts of the world and at latitudes not previously covered by the Tropical Rainfall Measuring Mission (TRMM. According to this study, one could expect an underestimation of the precipitation product by the dual-frequency precipitation radar (DPR also in other mountainous areas of the world.

  20. Děti v předškolním věku a volný čas

    OpenAIRE

    LOMOVÁ, Michaela

    2016-01-01

    This thesis deals with leisure time of preschool children. The theoretical part describes the preschool children in view of their development, the importance of family, kindergarten and leisure. It also discusses the free time where there are defined basic concepts, as well as functions of leisure time, the factors that affect leisure and specifics of children's leisure time. Finally, it is engaged in activities related to the leisure time of preschool children. The principal activity is the ...

  1. Generování plynného singletového kyslíku pro interakční experimenty

    Czech Academy of Sciences Publication Activity Database

    Čenský, Miroslav; Jirásek, Vít; Schmiedberger, Josef; Kodymová, Jarmila

    2016-01-01

    Roč. 110, č. 1 (2016), s. 11-17 ISSN 0009-2770 R&D Projects: GA ČR GAP102/12/0723 Institutional support: RVO:68378271 Keywords : singlet oxygen * chemical generators of singlet oxygen * discharge generator of singlet oxygen Subject RIV: BH - Optics, Masers, Lasers Impact factor: 0.387, year: 2016

  2. Metafory historické nadřazenosti poznání v raném novověku

    Czech Academy of Sciences Publication Activity Database

    Špelda, Daniel

    2015-01-01

    Roč. 12, Supplementum 2 (2015), s. 165-180 ISSN 1214-8407 R&D Projects: GA ČR GB14-37038G Institutional support: RVO:67985955 Keywords : the idea of scientific progress * scientific metaphors * early modern philosophy * early modern science Subject RIV: AA - Philosophy ; Religion

  3. Kulturní hodnoty tzv. Mariánského trojúhelníku - Sloup, Vranov, Křtiny

    OpenAIRE

    Bezděková, Veronika

    2009-01-01

    In the Moravian Karst there are three big churches consecrated to The Virgin Mary. These are visited by many pilgrims and have their own calendar of pilgrimages. They are Vranov, Křtiny and Sloup. Churches in these towns are consecrated to The Virgin Mary: Vranov commemorates the birth of The Virgin Mary, Křtiny commemorates the name of The Virgin Mary and Sloup commemorates the sufferings of The Virgin Mary. So we talk about the triangle of The Virgin Mary. This term is the main point of my ...

  4. Vladislavský sál Pražského hradu ve světle nových nálezů. Příspěvek k dějinám každodennosti pozdního středověku a raného novověku

    Czech Academy of Sciences Publication Activity Database

    Blažková, Gabriela; Frolík, Jan; Matiášek, Josef

    2016-01-01

    Roč. 19, č. 2 (2016), s. 27-50 ISSN 0862-979X R&D Projects: GA ČR GP13-34374P Institutional support: RVO:67985912 Keywords : Prague * Early Modern Age * Vladislaus Hall * plant macro-remains * paper playing card Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  5. Zlomek knihy vydání, v níž jsou jména Židů. “Nově objevený” rukopisný zlomek kupeckého rejstříku a jeho výpověď pro pražský obchod ve středověku

    Czech Academy of Sciences Publication Activity Database

    Musílek, Martin

    -, č. 44 (2016), s. 141-166 ISSN 0555-0238 R&D Projects: GA ČR(CZ) GBP405/12/G148 Institutional support: RVO:67985955 Keywords : Prague * Prague’s Old Town * business and trade * merchant books * merchant registers * manuscript fragment * Jews * Jewish Town * collateral * urban elites Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  6. Stručný dotazník dětského slovníku: vývoj a normy nástroje pro screening vývoje jazyka v raném věku

    Czech Academy of Sciences Publication Activity Database

    Smolík, Filip; Bytešníková, I.

    2017-01-01

    Roč. 61, č. 5 (2017), s. 460-473 ISSN 0009-062X R&D Projects: GA ČR GA13-26779S Grant - others:AV ČR(CZ) StrategieAV21/14 Program:StrategieAV Institutional support: RVO:68081740 Keywords : language acquisition * developmental screening * vocabulary Subject RIV: AN - Psychology OBOR OECD: Psychology, special (including therapy for learning, speech, hearing, visual and other physical and mental disabilities) Impact factor: 0.242, year: 2016

  7. Výměna stárnoucí manželky za hezkou mladou kočku aneb K exemplifikaci v Akademickém slovníku současné češtiny

    Czech Academy of Sciences Publication Activity Database

    Lišková, Michaela

    2017-01-01

    Roč. 100, č. 1 (2017), s. 28-36 ISSN 0027-8203 R&D Projects: GA MK DF13P01OVV011 Keywords : dictionary example * exemplification * gender * lexicography * monolingual dictionary * political correctness Subject RIV: AI - Linguistics

  8. Vertical evolution of the Cínovec granite cupola – chemical and mineralogical record

    Czech Academy of Sciences Publication Activity Database

    Breiter, Karel

    2016-01-01

    Roč. 46 (2016), s. 4-6 E-ISSN 1434-7512. [Late Paleozoic magmatism in the Erzgebirge / Krušné hory: Magma genesis, tectonics, geophysics, and mineral deposits : abstracts. 11.11.2016-12.11.2016, Freiberg] R&D Projects: GA ČR GA14-13600S Institutional support: RVO:67985831 Keywords : granite * Cínovec * geology * mineralogy * geochemistry Subject RIV: DB - Geology ; Mineralogy http://tu-freiberg.de/sites/default/files/media/institut-fuer-geologie-718/pdf/fog_volume_46.pdf

  9. Acute Respiratory Viral Infection in Children: Modern Approaches to Diagnosis and Treatment

    Directory of Open Access Journals (Sweden)

    Alexander A. Baranov

    2017-01-01

    Full Text Available The article is devoted to acute respiratory viral infections (ARVI in children. ARVI take one of the leading places in a childhood morbidity structure. The article provides an overview of the clinical guidelines developed and approved by the professional association «Union of Pediatricians of Russia» for acute respiratory infections in children. These guidelines summarize the experience of the leading world and domestic specialists, contain scientific and practical data that correspond to the most relevant trends in the management of children with this pathology. The authors present modern information on the etiology, pathogenesis, classification, clinical findings and differential diagnosis of various nosological forms of acute respiratory tract infections in the pediatric population. The general (strategic principles of drug-free and drug treatment are discussed in detail.

  10. Severe bronchial asthma in children: the role of clinical and anamnestic indices in diagnosis verification

    Directory of Open Access Journals (Sweden)

    Kolyubakina L.V.

    2016-03-01

    Full Text Available The paper presents comparative analysis of results of clinical and anamnestic examination of children depending on the asthma severity. Severe asthma in schoolchildren relative to moderate phenotype characterized by birth overweight, more burdened individual allergic history, highly infectious index, drug or combined (medication, food and household allergies, seasonal exacerbations (mainly from November to March, what associated with the trigger role of ARVI and meteorological factors, inadequate asthma control during standard basic therapy.

  11. THE ROLE OF INTERFERON PREPARATIONS IN THE TREATMENT OF ACUTE VIRAL RESPIRATORY INFECTIONS IN INFANTS, BABIES AND TODDLERS (RESULTS OF A MULTICENTER COMPARATIVE RANDOMIZED CLINICAL TRIAL

    Directory of Open Access Journals (Sweden)

    L.V. Feklisova

    2011-01-01

    Full Text Available The paper analyzes the results of a comparative clinical trial of drugs recombinant human interferon alpha-2b in the dosage form of suppositories for their use in the treatment of ARVI in infants, babies and toddlers age. In accordance to the selection criteria 100 children who were hospitalized, aged from 6 months to 3 years with clinically diagnosed ARVI were included in the study. Two study groups were formed: basic, which patients within 5 days received suppositories containing taurine and interferon alpha (125,000 IU,  and the comparison group, where patients received suppositories with interferon (150,000 IU. The patients of both groups were subjects of medical observation for 5 days with an estimate of the effectiveness of treatment on the 6th day of therapy. The eliminating activity of the exploring drugs was determined using standard laboratory techniques (PCR or DFA scrapings from the nasopharynx. The study established the high effectiveness and wide safety profile of both drugs. No cases of the adverse events that have established link with the study medications. Key words: influenza, ARVI, recombinant human interferon alpha-2b, taurine, suppositories, children. (Pediatric Pharmacology. — 2011; 8 (5: 76–82.

  12. The new uranium mining boom. Challenge and lessons learned

    International Nuclear Information System (INIS)

    Merkel, Broder; Schipek, Mandy

    2011-01-01

    The book presents the results from the Uranium Mining and Hydrogeology Conference (UMH VI) held in September 2011, in Freiberg, Germany. The following subjects are dealt with in depth: uranium mining, phosphate mining and uranium recovery. Cleaning up technologies for water and soil are also discussed at length. Analystics and sensors for uranium and radon and modelling round up this comprehensive volume. (orig.)

  13. Why I Will Not Become a Teacher

    Science.gov (United States)

    Wolter-Gustafson, Melissa

    2004-01-01

    The author of this article describes why, while as a student in the Northeastern University teacher preparation program, she chose not to become a teacher in the public schools. She felt that her philosophy of education, stemming from the concept of the person-centered classroom as espoused by Carl Rogers and Jerome Freiberg in "Freedom to…

  14. Comparative measurements with seven rainfall simulators on uniform bare fallow land

    NARCIS (Netherlands)

    Iserloh, T.; Ries, J.B.; Cerda, A.; Echeverria, M.T.; Fister, W.; Geissler, C.; Kuhn, N.J.; Leon, F.J.; Peters, P.; Schindewolf, M.; Schmidt, J.; Scholten, T.; Seeger, K.M.

    2013-01-01

    To assess the influence of rainfall simulator type and plot dimensions on runoff and erosion, seven small portable rainfall simulators from Freiberg, Tubingen, Trier (all Germany), Valencia, Zaragoza (both Spain), Basel (Switzerland) and Wageningen (the Netherlands) were compared on a prepared bare

  15. 217 An International Multi-Disciplinary Journal, Ethiopia Vol. 4 (1 ...

    African Journals Online (AJOL)

    FIRST LADY

    An alternative structure exist when a party does not perceive sufficiently important interest .... Considering the grand strategies of the superpowers during the cold war,. Freiberg .... the two adversaries; how they construct and interpret reality; and the. “bounded ... to loss… it can only make people behave to avoid it. The only.

  16. The Carboniferous - Permian basins of Central and Western Bohemia, the Krkonoše Mt. foreland and the Bohemian Massif, Czech Republic : part I

    Czech Academy of Sciences Publication Activity Database

    Opluštil, S.; Martínek, K.; Lojka, R.; Rosenau, N.; Zajíc, Jaroslav; Šimůnek, Z.; Drábková, J.; Štamberg, S.

    2014-01-01

    Roč. 46, č. 1 (2014), s. 14-54 ISSN 1433-1284. [Field Meeting on Carboniferous and Permian Nonmarine – Marine Correlation. Freiberg, 21.07.2014-27.07.2014] Institutional support: RVO:67985831 Keywords : Carboniferous * Permian * excursion guide Subject RIV: DB - Geology ; Mineralogy

  17. Barrandian of the Prague Basin: Field Observations, Analyses and Numerical Simulation of Petroleum Generation-Migration

    Czech Academy of Sciences Publication Activity Database

    Mann, U.; Volk, H.; Suchý, Václav; Franců, J.; Filip, Jiří; Glasmacher, U.; Radke, M.; Sýkorová, Ivana; Wagner, G.; Wilkes, H.; Zeman, Antonín

    č. 1 (1999), s. 142 ISSN 0946-8978. [Old Crust - New Problems: Geodynamics and Utilization Includes the final international colloquium of the DFG priority programme Orogenic Processes Quantification and Modeling in the Variscan Belt. 22.02.1999-26.02.1999, Freiberg/Saxony] Subject RIV: DB - Geology ; Mineralogy

  18. Riia - Torun. Järelmõtteid kahelt festivalilt / Boris Tuch ; tõlk. Madis Kolk

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2005-01-01

    "Balti teatrikevad" Riias ja "Kontakt" Torunis. Lähemalt lavastustest : M. Ivashkeviciuse "Madagaskar" (lav. R. Tuminas), "White Star" (lav. L. Pauwels), A. Kivirähki "Romeo ja Julia"(lav. M. Unt) ja "Eesti matus" (lav. P. Pedajas), "Kutse ihunuhtlusele" (E. Freibergs), V. Sigarevi "Must piim" (lav. P. Gothar), I. Võrõpajevi "Eksistents number kaks" (lav. V. Rõzhakov), "Macbeth" (lav. M. Kleczewska)

  19. 77 FR 64375 - Advisory Council on Transportation Statistics; Notice of Meeting

    Science.gov (United States)

    2012-10-19

    ... of Transportation Statistics (BTS) on the quality, reliability, consistency, objectivity, and...) Update on BTS data programs and future plans; (5) Council Members review and discussion of BTS programs... Freiberg, 1200 New Jersey Avenue SE., Room E34-429, Washington, DC 20590, or faxed to (202) 366-3640. BTS...

  20. IFLA General Conference, 1985. Division on Special Libraries. Section on Science and Technology Libraries. Papers.

    Science.gov (United States)

    International Federation of Library Associations, The Hague (Netherlands).

    Papers on science and technology libraries which were presented at the 1985 International Federation of Library Associations (IFLA) conference include: (1) "UAP (Universal Availability of Publications) and User Training for Categories of Grey Literature" (Dieter Schmidmaier, Mining Academy Freiberg, East Germany); (2) "Resource…

  1. National Security and the Right to Information in Europe

    DEFF Research Database (Denmark)

    Jacobsen, Amanda Lynn

    2013-01-01

    Full text available at: http://cast.ku.dk/pdf/National_Security_and_the_Right_to_Information.pdf/......Full text available at: http://cast.ku.dk/pdf/National_Security_and_the_Right_to_Information.pdf/...

  2. Siim Nestor soovitab : Back2Bass Helsinki. Teenage Kicks / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2002-01-01

    Soome trummi-ja-bassi klubi Back2Bass 28. septembril KuKu klubis Tallinnas. 28. sept. Von Krahlis toimuvast live-üritusest Teenage Kicks, kus ansambel Claire's Birthaday esitleb ka oma uut singlit "Do You Remember"

  3. Ginsbergi vennaskond, värskelt ühendatud / Marko Mägi

    Index Scriptorium Estoniae

    Mägi, Marko

    2005-01-01

    Poetry slami laadis luuleõhtul "Poesie United" esinesid 21. mail KuKu klubis Wehwalt Koslovsky, Tobias Hoffmann (Saksamaa), Ben Porter Lewis, Milo Martin (USA), Antoine Faure (Prantsusmaa), fs, Asko Künnap, Jürgen Rooste

  4. Uudised : "Odessa Pop uuel ringil". Neoandertals jõuab plaadile. "Xanadu" Hollandis muusikalilaval

    Index Scriptorium Estoniae

    2007-01-01

    Kontsertõhtust sarja Odessa Pop raames 17. veebr. Tallinnas baar-klubis Juuksur. Ultrabrutaalse deathmetali duo Neoandertals heliplaadi "Neanderthals Were Master Butchers" esitluskontserdist 17. veebr. Tallinnas KuKu klubis. 1980. aastal valminud diskofilmi "Xanadu" muusikaliversioonist

  5. Siim Nestor soovitab : Tallinn Doom Night vol.1. Odessa Pop / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2006-01-01

    Soome doom-metal ansambel Reverend Bizarre üritusel "Tallinn Doom Night vol.1" 8. dets. klubis Rockstar's. Indipoppi viljelev Rootsi duo My Darling Yoy! üritusel "Odessa Pop" 9. dets. Tallinnas klubis KuKu

  6. Organizational Analysis of the United States Army Contracting Command-Kuwait

    National Research Council Canada - National Science Library

    Orr, Kristine R

    2008-01-01

    This study of the U.S. Army Contracting Command - Kuwait (USACC-KU) used an organizational systems framework to analyze factors related to strategy structure, processes and results experienced at USACC-KU during 2006-2008...

  7. Gridded 5-day mean sea surface height anomaly and significant wave height from Jason-1 and OSTM/Jason-2 satellites (NODC Accession 0065055)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contains the gridded 5-day mean sea surface height anomaly (SSHA) and Ku Band significant wave height (SWH-KU) observed from Jason-1 and OSTM/Jason-2...

  8. Siim Nestor soovitab : Odessa Pop. Neoandertals / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2007-01-01

    Indieüritusest Odessa Pop 17. veebr. Tallinnas baar-klubis Juuksur. Ultrabrutaalse death-metali duo Neoandertals heliplaadi "Neoandertals Were Master Butchers" esitluskontserdist 17. veebr. Tallinnas KuKu klubis

  9. A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk.

    Science.gov (United States)

    González, Silvia; Fló, Martín; Margenat, Mariana; Durán, Rosario; González-Sapienza, Gualberto; Graña, Martín; Parkinson, John; Maizels, Rick M; Salinas, Gustavo; Alvarez, Beatriz; Fernández, Cecilia

    2009-09-17

    The cestode Echinococcus granulosus, the agent of hydatidosis/echinococcosis, is remarkably well adapted to its definitive host. However, the molecular mechanisms underlying the successful establishment of larval worms (protoscoleces) in the dog duodenum are unknown. With the aim of identifying molecules participating in the E. granulosus-dog cross-talk, we surveyed the transcriptomes of protoscoleces and protoscoleces treated with pepsin at pH 2. This analysis identified a multigene family of secreted monodomain Kunitz proteins associated mostly with pepsin/H(+)-treated worms, suggesting that they play a role at the onset of infection. We present the relevant molecular features of eight members of the E. granulosus Kunitz family (EgKU-1 - EgKU-8). Although diverse, the family includes three pairs of close paralogs (EgKU-1/EgKU-4; EgKU-3/EgKU-8; EgKU-6/EgKU-7), which would be the products of recent gene duplications. In addition, we describe the purification of EgKU-1 and EgKU-8 from larval worms, and provide data indicating that some members of the family (notably, EgKU-3 and EgKU-8) are secreted by protoscoleces. Detailed kinetic studies with native EgKU-1 and EgKU-8 highlighted their functional diversity. Like most monodomain Kunitz proteins, EgKU-8 behaved as a slow, tight-binding inhibitor of serine proteases, with global inhibition constants (K(I) (*)) versus trypsins in the picomolar range. In sharp contrast, EgKU-1 did not inhibit any of the assayed peptidases. Interestingly, molecular modeling revealed structural elements associated with activity in Kunitz cation-channel blockers. We propose that this family of inhibitors has the potential to act at the E. granulosus-dog interface and interfere with host physiological processes at the initial stages of infection.

  10. Hard X-Ray Properties of the Merging Cluster Abell 3667 as Observed with Suzaku

    Science.gov (United States)

    2008-08-01

    3667 as Observed with Suzaku Kazuhiro NAKAZAWA Department of Physics, The University of Tokyo, 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-0033 nakazawa...of Tokyo, 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-0033 Kazuo MAKISHIMA Department of Physics, The University of Tokyo, 7-3-1 Hongo , Bunkyo-ku, Tokyo 113

  11. Multilingvismus u dětí předškolního a mladšího školního věku

    OpenAIRE

    Šaumanová, Kristina

    2016-01-01

    This thesis focuses on bilingualism and multilingualism in children of preschool and primary school age and is intended as a source of information on multilingual education of young children. This thesis comprises of theoretical research into the technical aspects of bilingualism and multilingualism, based on academic literature, the approach to multilingual education and the linguistic aspects connected to multilingual education. The practical part contains the reflections of families who ha...

  12. K rozmnožení cti a chvály Boží a ku prospěchu vlasti. Mikuláš Walter z Waltersperku († 1578) a jeho studijní nadace

    Czech Academy of Sciences Publication Activity Database

    Holá, M.; Holý, Martin

    2013-01-01

    Roč. 28, č. 1 (2013), s. 5-27 ISSN 0231-7494 R&D Projects: GA ČR GPP405/12/P422 Institutional support: RVO:67985963 Keywords : educational foundations * Mikuláš Walter of Waltersperk * Prague University * Early Modern Period Subject RIV: AB - History

  13. Specifika výuky snowboardingu v předškolním a mladším školním věku.

    OpenAIRE

    KUŠNIRENKOVÁ, Viktorie

    2009-01-01

    Bachelor labour be angaged problems about snowboarding and younger pupilages. Author mentioning about history of snowboarding and domicile of origin, in Europe and Czech Republic. Then author be focusing principally evolutionary psychology. In bachelour labour are comparing individual methodology elements singl authors. On this part then Conner research. Author of bachelou labour in practical part conducts education of beginning children of younger pupilage. Produc of bachelours labour is "Le...

  14. Ošetřovatelská péče u klientů s inkontinencí moči dlouhodobě upoutaných na lůžku.

    OpenAIRE

    KUBÍKOVÁ, Nikola

    2014-01-01

    Bachelor thesis titled ,,Nursing care for long-term bedridden patients with urinary incontinence" deals with the nursing care of clients with urinary incontinence has long restrained on a bed on the aftercare department. Urinary incontinence is a condition of involuntary leakage of urine, which is a major health and social problem (Kalvach and team, 2004). According to the International Continence Society (ICS) urinary incontinence is classified into extraurethal and urethral. Extraurethal in...

  15. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Chuo Ward, Kobe); 1999 nendo Welfare Techno system kenkyu kaihatsu (Kobe-shi Chuo-ku) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed on a help and welfare system to transmit and accumulate monitoring data by utilizing a computer system. This paper summarizes the achievements in fiscal 1999. In the research of transmission and management of information on help requiring persons, a server and its peripheral devices were modified to structure a system to measure body temperatures, pulses, and blood pressures, and transmit them to a central server. In the research on support for the visiting helps, a mobile system was developed, which has map information and scheduling function that shows distribution of help requiring persons. In the research of a simulation to link hospitals, medical organizations and homes, the LAN at health facilities for elderly people was structured, and so was a network for linking hospitals, medical organizations and homes (simulated). Investigations and discussions were performed on interface between body information (vital data) measuring instruments and personal computers. Developmental research was executed on private certification office servers and the certification software that consider security in the help systems. (NEDO)

  16. Srovnání pěstování kakaovníku pravého (Theobroma cacao L.) v agrolesnických a monokulturních systémech

    OpenAIRE

    Andrušíková, Petra

    2016-01-01

    Bachelor thesis contains characteristic of species Theobroma cacao. In this work is described origin and history, processing and world market with cocoa beans. In work is compared cultivation at plantation in agroforestry and monoculture systems. There is compared the benefits and disadvantages of usage of this systems. In the work is mentioned some informations about world organization, which are interested in agroforestry and also agroforestry certification.

  17. Vliv akumulace dusíku na vřesoviště a suché trávníky v Národním parku Podyjí

    Czech Academy of Sciences Publication Activity Database

    Záhora, J.; Chytrý, M.; Holub, Petr; Fiala, Karel; Tůma, I.; Vavříková, J.; Fabšičová, Martina; Keizer, I.; Fillipová, L.

    2016-01-01

    Roč. 50, č. 2 (2016), s. 97-107 ISSN 0044-4863 R&D Projects: GA MZe QJ1220007; GA ČR GA206/02/0581; GA ČR(CZ) GA526/06/0556 Institutional support: RVO:67179843 ; RVO:67985939 Keywords : Arrhenatherum elatius , soil, české Podyji National Park * atmospheric nitrogen deposition * Calluna vulgaris * Calamagrostis epigejos * Festuca ovina * soil * české Podyji National Park Subject RIV: DF - Soil Science; EF - Botanics (BU-J)

  18. Metoda měření chemické mikroheterogenity uhlíku v plynule litých ocelových blocích

    Czech Academy of Sciences Publication Activity Database

    Stránský, K.; Rek, Antonín; Dobrovská, J.; Dobrovská, V.; Kavička, F.; Sekanina, B.

    2013-01-01

    Roč. 66, č. 5 (2013), s. 66-73 ISSN 0018-8069 Institutional support: RVO:68081731 Keywords : steel block * wave dispersive X ray * spectral micro analysis * effective partition coefficients * heterogeneity index * mass concentration C, Mn, Si, P Subject RIV: JG - Metallurgy

  19. Současný stav a možnosti řešení dětského kuřáctví

    OpenAIRE

    VÁVROVÁ, Eva

    2008-01-01

    The paper has theoretical and practical part. The theoretical part involves information on smoking history, substances contained in cigarettes and it also focuses on smoking impacts to children health, adults, pregnant women and human fertility. Other sections focus on smoking and related legislation, a theory of addiction development and its treatments. The theoretical part ends with the detailed description of a juvenile smoking phenomenon focusing on prevention schemes, how to prevent chil...

  20. Po stopách dobytka a drůbeže v materiálu Slovníku pomístních jmen na Moravě a ve Slezsku

    Czech Academy of Sciences Publication Activity Database

    Spinková, Stanislava

    2010-01-01

    Roč. 51, č. 1 (2010), s. 202-226 ISSN 1211-4413 R&D Projects: GA ČR GA405/08/0703 Institutional research plan: CEZ:AV0Z90610518 Keywords : anoikonyms * cattle * sheep and poultry * pasture * common land * wet ground Subject RIV: AI - Linguistics